Search of human proteins with 21361088

Search of human proteins with 21361088

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21361088 sphingosine kinase 1 isoform 1 [Homo sapiens]
         (398 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21361088 sphingosine kinase 1 isoform 1 [Homo sapiens]             810   0.0  
gi|217272885 sphingosine kinase 1 isoform 3 [Homo sapiens]            774   0.0  
gi|217272883 sphingosine kinase 1 isoform 3 [Homo sapiens]            774   0.0  
gi|217272880 sphingosine kinase 1 isoform 2 [Homo sapiens]            774   0.0  
gi|21361699 sphingosine kinase 2 [Homo sapiens]                       253   2e-67
gi|20336726 ceramide kinase [Homo sapiens]                             94   3e-19
gi|8922701 acylglycerol kinase [Homo sapiens]                          83   4e-16
gi|41680688 ceramide kinase-like isoform a [Homo sapiens]              68   2e-11
gi|71896723 ceramide kinase-like isoform b [Homo sapiens]              54   2e-07
gi|4758156 diacylglycerol kinase, iota [Homo sapiens]                  35   0.12 
gi|22748651 ORAI calcium release-activated calcium modulator 3 [...    31   1.7  
gi|71896711 ceramide kinase-like isoform d [Homo sapiens]              30   3.8  
gi|54112121 splicing factor 3b, subunit 3 [Homo sapiens]               30   5.0  
gi|239751469 PREDICTED: hypothetical protein [Homo sapiens]            30   5.0  
gi|144226234 metastasis suppressor 1 [Homo sapiens]                    30   5.0  
gi|187282992 hypothetical protein LOC392145 [Homo sapiens]             29   6.5  
gi|53829370 neuralized homolog 4 isoform 1 [Homo sapiens]              29   8.5  
gi|53829368 neuralized homolog 4 isoform 2 [Homo sapiens]              29   8.5  
gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens]          29   8.5  
gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens]          29   8.5  
gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens]          29   8.5  
gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens]          29   8.5  

>gi|21361088 sphingosine kinase 1 isoform 1 [Homo sapiens]
          Length = 398

 Score =  810 bits (2092), Expect = 0.0
 Identities = 398/398 (100%), Positives = 398/398 (100%)

Query: 1   MDPVVGCGRGLFGFVFSAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAE 60
           MDPVVGCGRGLFGFVFSAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAE
Sbjct: 1   MDPVVGCGRGLFGFVFSAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAE 60

Query: 61  ISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLC 120
           ISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLC
Sbjct: 61  ISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLC 120

Query: 121 SLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSV 180
           SLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSV
Sbjct: 121 SLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSV 180

Query: 181 LSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASP 240
           LSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASP
Sbjct: 181 LSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASP 240

Query: 241 VVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMH 300
           VVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMH
Sbjct: 241 VVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMH 300

Query: 301 LFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMV 360
           LFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMV
Sbjct: 301 LFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMV 360

Query: 361 SEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL 398
           SEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
Sbjct: 361 SEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL 398


>gi|217272885 sphingosine kinase 1 isoform 3 [Homo sapiens]
          Length = 384

 Score =  774 bits (1998), Expect = 0.0
 Identities = 381/381 (100%), Positives = 381/381 (100%)

Query: 18  AGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHAREL 77
           AGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHAREL
Sbjct: 4   AGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHAREL 63

Query: 78  VRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHY 137
           VRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHY
Sbjct: 64  VRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHY 123

Query: 138 AGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEK 197
           AGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEK
Sbjct: 124 AGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEK 183

Query: 198 YRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEE 257
           YRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEE
Sbjct: 184 YRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEE 243

Query: 258 PVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLF 317
           PVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLF
Sbjct: 244 PVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLF 303

Query: 318 LAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVS 377
           LAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVS
Sbjct: 304 LAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVS 363

Query: 378 GCVEPPPSWKPQQMPPPEEPL 398
           GCVEPPPSWKPQQMPPPEEPL
Sbjct: 364 GCVEPPPSWKPQQMPPPEEPL 384


>gi|217272883 sphingosine kinase 1 isoform 3 [Homo sapiens]
          Length = 384

 Score =  774 bits (1998), Expect = 0.0
 Identities = 381/381 (100%), Positives = 381/381 (100%)

Query: 18  AGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHAREL 77
           AGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHAREL
Sbjct: 4   AGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHAREL 63

Query: 78  VRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHY 137
           VRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHY
Sbjct: 64  VRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHY 123

Query: 138 AGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEK 197
           AGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEK
Sbjct: 124 AGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEK 183

Query: 198 YRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEE 257
           YRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEE
Sbjct: 184 YRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEE 243

Query: 258 PVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLF 317
           PVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLF
Sbjct: 244 PVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLF 303

Query: 318 LAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVS 377
           LAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVS
Sbjct: 304 LAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVS 363

Query: 378 GCVEPPPSWKPQQMPPPEEPL 398
           GCVEPPPSWKPQQMPPPEEPL
Sbjct: 364 GCVEPPPSWKPQQMPPPEEPL 384


>gi|217272880 sphingosine kinase 1 isoform 2 [Homo sapiens]
          Length = 470

 Score =  774 bits (1998), Expect = 0.0
 Identities = 381/381 (100%), Positives = 381/381 (100%)

Query: 18  AGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHAREL 77
           AGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHAREL
Sbjct: 90  AGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHAREL 149

Query: 78  VRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHY 137
           VRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHY
Sbjct: 150 VRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHY 209

Query: 138 AGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEK 197
           AGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEK
Sbjct: 210 AGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEK 269

Query: 198 YRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEE 257
           YRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEE
Sbjct: 270 YRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEE 329

Query: 258 PVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLF 317
           PVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLF
Sbjct: 330 PVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLF 389

Query: 318 LAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVS 377
           LAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVS
Sbjct: 390 LAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVS 449

Query: 378 GCVEPPPSWKPQQMPPPEEPL 398
           GCVEPPPSWKPQQMPPPEEPL
Sbjct: 450 GCVEPPPSWKPQQMPPPEEPL 470


>gi|21361699 sphingosine kinase 2 [Homo sapiens]
          Length = 654

 Score =  253 bits (646), Expect = 2e-67
 Identities = 127/238 (53%), Positives = 169/238 (71%), Gaps = 5/238 (2%)

Query: 24  VLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEEL 83
           +LPRP R+L+L+NP GG+G A Q  ++HV P+++EA +SF L+ TER+NHARELV+   L
Sbjct: 176 LLPRPPRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSL 235

Query: 84  GRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQV 143
             WD +V +SGDGL+HEV+NGL++RPDWE A++ P+  LP GSGNALA ++N + G+E  
Sbjct: 236 SEWDGIVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPA 295

Query: 144 TNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGE 203
              DLL NC+LLLCR    P++LLS+  ASG R FS LS+AWGF++DVD++SE++R LG 
Sbjct: 296 LGLDLLLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGS 355

Query: 204 MRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGP-VDAHLVPLEEPVP 260
            RFTLGT L LA L TYRGRL+YLP     +  PASP      P   + L    +P P
Sbjct: 356 ARFTLGTVLGLATLHTYRGRLSYLP----ATVEPASPTPAHSLPRAKSELTLTPDPAP 409



 Score =  123 bits (308), Expect = 3e-28
 Identities = 69/151 (45%), Positives = 91/151 (60%), Gaps = 9/151 (5%)

Query: 228 PVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMF 287
           P  RVG+ T         GP D  L PL  P+P  W  + + DFVL+LA+  SHLG+++ 
Sbjct: 504 PDARVGASTC--------GPPDHLLPPLGTPLPPDWVTL-EGDFVLMLAISPSHLGADLV 554

Query: 288 AAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKD 347
           AAP  R   G++HL +VR+G+SRA LLRLFLAME+G H    CP L Y    AFRLEP  
Sbjct: 555 AAPHARFDDGLVHLCWVRSGISRAALLRLFLAMERGSHFSLGCPQLGYAAARAFRLEPLT 614

Query: 348 GKGVFAVDGELMVSEAVQGQVHPNYFWMVSG 378
            +GV  VDGE +    +Q Q+HP    +++G
Sbjct: 615 PRGVLTVDGEQVEYGPLQAQMHPGIGTLLTG 645


>gi|20336726 ceramide kinase [Homo sapiens]
          Length = 537

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 65/227 (28%), Positives = 108/227 (47%), Gaps = 22/227 (9%)

Query: 27  RPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRW 86
           RP  +LV +NP GGKG+  +++   V PL   A I+  +++TE  N A+E +    + ++
Sbjct: 129 RPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETLYEINIDKY 188

Query: 87  DALVVMSGDGLMHEVVNGLMERPDWETAIQK------------PLCSLPAGSGNALAASL 134
           D +V + GDG+  EV++GL+ R      + +             +  +PAGS + +    
Sbjct: 189 DGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGSTDCVC--- 245

Query: 135 NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE 194
                Y  V   D  T+   ++    L+ M++ S+H  S L  +SV  L +GF  D+  +
Sbjct: 246 -----YSTVGTSDAETSALHIVVGDSLA-MDVSSVHHNSTLLRYSVSLLGYGFYGDIIKD 299

Query: 195 SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGR-VGSKTPASP 240
           SEK R LG  R+         +   Y G +++LP    VGS     P
Sbjct: 300 SEKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKP 346


>gi|8922701 acylglycerol kinase [Homo sapiens]
          Length = 422

 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 57/215 (26%), Positives = 102/215 (47%), Gaps = 9/215 (4%)

Query: 30  RVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDAL 89
           +  V LNP   KGKA  LF  +  P+L  + +  T++ T+    A++L+  E +   D +
Sbjct: 62  KATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLL--ELMENTDVI 119

Query: 90  VVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLL 149
           +V  GDG + EVV G++ R D  T  + P+  +P G      +SL+H    E       +
Sbjct: 120 IVAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGE----TSSLSHTLFAESGNKVQHI 175

Query: 150 TNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLG 209
           T+ TL + +    P+++L +       +F++  L WG   D  ++  KY  LG ++    
Sbjct: 176 TDATLAIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAA 235

Query: 210 TFLRLAA--LRTYRGRLAYL-PVGRVGSKTPASPV 241
            F        +T++  ++Y  P  R  ++   +PV
Sbjct: 236 HFFSTLKEWPQTHQASISYTGPTERPPNEPEETPV 270


>gi|41680688 ceramide kinase-like isoform a [Homo sapiens]
          Length = 532

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 63/214 (29%), Positives = 95/214 (44%), Gaps = 22/214 (10%)

Query: 27  RPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRW 86
           RP  + +LLNP+  K +A Q++   V+PLL  A I   + + E   HA  L++  EL  +
Sbjct: 165 RPKSLKILLNPQSHKKEATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGF 224

Query: 87  DALVVMSGDGLMHEVVNGLMERPDWETAI-----------QKPLCSLPAGSGNALAASLN 135
           D +V + GDG   EV + L+ R      +           Q PL  +PAGS N LA SL+
Sbjct: 225 DGVVCVGGDGSASEVAHALLLRAQKNAGMETDRILTPVRAQLPLGLIPAGSTNVLAHSLH 284

Query: 136 HYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLES 195
              G   V         TL +    +  +++ +  TA  L  F   S  +GF       +
Sbjct: 285 ---GVPHV------ITATLHIIMGHVQLVDVCTFSTAGKLLRFG-FSAMFGFGGRTLALA 334

Query: 196 EKYRRLG-EMRFTLGTFLRLAALRTYRGRLAYLP 228
           EKYR +    R        LA L+     +++LP
Sbjct: 335 EKYRWMSPNQRRDFAVVKALAKLKAEDCEISFLP 368


>gi|71896723 ceramide kinase-like isoform b [Homo sapiens]
          Length = 558

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 63/240 (26%), Positives = 96/240 (40%), Gaps = 48/240 (20%)

Query: 27  RPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRW 86
           RP  + +LLNP+  K +A Q++   V+PLL  A I   + + E   HA  L++  EL  +
Sbjct: 165 RPKSLKILLNPQSHKKEATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGF 224

Query: 87  D--------------------------ALVVMSGDGLMHEVVNGLMERPDWETAI----- 115
           D                          ++V + GDG   EV + L+ R      +     
Sbjct: 225 DGGHRKPLFAIHWSVQRLFTGMQTLEPSVVCVGGDGSASEVAHALLLRAQKNAGMETDRI 284

Query: 116 ------QKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSL 169
                 Q PL  +PAGS N LA SL+   G   V         TL +    +  +++ + 
Sbjct: 285 LTPVRAQLPLGLIPAGSTNVLAHSLH---GVPHV------ITATLHIIMGHVQLVDVCTF 335

Query: 170 HTASGLRLFSVLSLAWGFIADVDLESEKYRRLG-EMRFTLGTFLRLAALRTYRGRLAYLP 228
            TA  L  F   S  +GF       +EKYR +    R        LA L+     +++LP
Sbjct: 336 STAGKLLRFG-FSAMFGFGGRTLALAEKYRWMSPNQRRDFAVVKALAKLKAEDCEISFLP 394


>gi|4758156 diacylglycerol kinase, iota [Homo sapiens]
          Length = 1065

 Score = 35.0 bits (79), Expect = 0.12
 Identities = 36/113 (31%), Positives = 53/113 (46%), Gaps = 15/113 (13%)

Query: 31  VLVLLNPRGGKG---KALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWD 87
           +LV +NP+ G     K LQ+F  ++ P        F L   E    A EL R     R  
Sbjct: 377 LLVFVNPKSGGNQGTKVLQMFMWYLNPRQV-----FDLS-QEGPKDALELYRKVPNLR-- 428

Query: 88  ALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGY 140
            ++   GDG +  +++ L E    + + Q P+  LP G+GN LA +LN   GY
Sbjct: 429 -ILACGGDGTVGWILSILDEL---QLSPQPPVGVLPLGTGNDLARTLNWGGGY 477


>gi|22748651 ORAI calcium release-activated calcium modulator 3
           [Homo sapiens]
          Length = 295

 Score = 31.2 bits (69), Expect = 1.7
 Identities = 33/126 (26%), Positives = 50/126 (39%), Gaps = 22/126 (17%)

Query: 148 LLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFT 207
           +++ C L     + +  NL S+H +   RL   + LAWGF                    
Sbjct: 114 MVSTCLLPHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGFST-----------------A 156

Query: 208 LGTFLRLAALRTYRGRLAYLPVGR-VGSKTPASPVVVQQG---PVDAHLVPLEEPVPSHW 263
           LGTFL LA +    G + ++P+G  + + TP  P     G   PV   L P      S  
Sbjct: 157 LGTFLFLAEV-VLVGWVKFVPIGAPLDTPTPMVPTSRVPGTLAPVATSLSPASNLPRSSA 215

Query: 264 TVVPDE 269
           +  P +
Sbjct: 216 SAAPSQ 221


>gi|71896711 ceramide kinase-like isoform d [Homo sapiens]
          Length = 463

 Score = 30.0 bits (66), Expect = 3.8
 Identities = 15/35 (42%), Positives = 22/35 (62%)

Query: 27  RPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEI 61
           RP  + +LLNP+  K +A Q++   V+PLL  A I
Sbjct: 165 RPKSLKILLNPQSHKKEATQVYYEKVEPLLKLAGI 199


>gi|54112121 splicing factor 3b, subunit 3 [Homo sapiens]
          Length = 1217

 Score = 29.6 bits (65), Expect = 5.0
 Identities = 19/73 (26%), Positives = 31/73 (42%)

Query: 297 GVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDG 356
           G +   Y+  G+   +LLR  L    G   +    YL   PV  FR+  +  + V A+  
Sbjct: 658 GSIGFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSS 717

Query: 357 ELMVSEAVQGQVH 369
              +S + Q + H
Sbjct: 718 RSWLSYSYQSRFH 730


>gi|239751469 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 278

 Score = 29.6 bits (65), Expect = 5.0
 Identities = 30/107 (28%), Positives = 38/107 (35%), Gaps = 17/107 (15%)

Query: 80  SEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAG 139
           S  +G W   + + G  L+    + L     W    Q PL    A S      S  H   
Sbjct: 157 SPAVGSWSRGIPVEGV-LLSPCAHSLRGSRGWAHPQQHPLAGTRAPSARGAGCSHTH--- 212

Query: 140 YEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWG 186
                    L+ C L L RRL   +N+L L  A G        LAWG
Sbjct: 213 -----THAQLSPCGLGLWRRLPRGLNILPLPDAQG--------LAWG 246


>gi|144226234 metastasis suppressor 1 [Homo sapiens]
          Length = 755

 Score = 29.6 bits (65), Expect = 5.0
 Identities = 24/80 (30%), Positives = 37/80 (46%), Gaps = 5/80 (6%)

Query: 195 SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVP 254
           S+ YRR+ + +    T    A L T  G     P      +TP++   V++G + A  +P
Sbjct: 555 SQSYRRMFQAKRPAST----AGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIP 610

Query: 255 LEEPV-PSHWTVVPDEDFVL 273
           ++ PV P     VPD   VL
Sbjct: 611 IKTPVIPVKTPTVPDLPGVL 630


>gi|187282992 hypothetical protein LOC392145 [Homo sapiens]
          Length = 174

 Score = 29.3 bits (64), Expect = 6.5
 Identities = 25/62 (40%), Positives = 29/62 (46%), Gaps = 14/62 (22%)

Query: 127 GNALAASLNH------YAGYEQVTNEDLLTNCTLLLCRR-----LLSPMNLLSLHTASGL 175
           G+ALA  LN       YAG E     DL+ +C L L        LL PM L   HTA G+
Sbjct: 97  GSALATELNTAKLALAYAGMEM---NDLVVSCGLGLAPGSVPTWLLDPMRLEEEHTAPGV 153

Query: 176 RL 177
            L
Sbjct: 154 TL 155


>gi|53829370 neuralized homolog 4 isoform 1 [Homo sapiens]
          Length = 1562

 Score = 28.9 bits (63), Expect = 8.5
 Identities = 20/61 (32%), Positives = 28/61 (45%), Gaps = 5/61 (8%)

Query: 218  RTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLAL 277
            RT++ ++A+    R GS TP  P      P D H  P E      W V  ++   L+ AL
Sbjct: 1503 RTHQAQVAFQVCVRPGSYTPGPPSAALGEPPDPHFSPAE----LEW-VTKEKGATLLCAL 1557

Query: 278  L 278
            L
Sbjct: 1558 L 1558


>gi|53829368 neuralized homolog 4 isoform 2 [Homo sapiens]
          Length = 1560

 Score = 28.9 bits (63), Expect = 8.5
 Identities = 20/61 (32%), Positives = 28/61 (45%), Gaps = 5/61 (8%)

Query: 218  RTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLAL 277
            RT++ ++A+    R GS TP  P      P D H  P E      W V  ++   L+ AL
Sbjct: 1501 RTHQAQVAFQVCVRPGSYTPGPPSAALGEPPDPHFSPAE----LEW-VTKEKGATLLCAL 1555

Query: 278  L 278
            L
Sbjct: 1556 L 1556


>gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
          Length = 735

 Score = 28.9 bits (63), Expect = 8.5
 Identities = 35/118 (29%), Positives = 51/118 (43%), Gaps = 11/118 (9%)

Query: 25  LPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELG 84
           +P    +LV +NP+ G GK  Q      Q +L   ++ F L L +       L +     
Sbjct: 371 VPNTHPLLVFVNPKSG-GKQGQRVLWKFQYILNPRQV-FNL-LKDGPEIGLRLFKDVPDS 427

Query: 85  RWDALVVMSGDGLMHEVVNGLMERPDWETA-IQKPLCSLPAGSGNALAASLNHYAGYE 141
           R   ++V  GDG     V  ++E  D     +  P+  LP G+GN LA  L    GYE
Sbjct: 428 R---ILVCGGDG----TVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYE 478


>gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
          Length = 735

 Score = 28.9 bits (63), Expect = 8.5
 Identities = 35/118 (29%), Positives = 51/118 (43%), Gaps = 11/118 (9%)

Query: 25  LPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELG 84
           +P    +LV +NP+ G GK  Q      Q +L   ++ F L L +       L +     
Sbjct: 371 VPNTHPLLVFVNPKSG-GKQGQRVLWKFQYILNPRQV-FNL-LKDGPEIGLRLFKDVPDS 427

Query: 85  RWDALVVMSGDGLMHEVVNGLMERPDWETA-IQKPLCSLPAGSGNALAASLNHYAGYE 141
           R   ++V  GDG     V  ++E  D     +  P+  LP G+GN LA  L    GYE
Sbjct: 428 R---ILVCGGDG----TVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYE 478


>gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
          Length = 735

 Score = 28.9 bits (63), Expect = 8.5
 Identities = 35/118 (29%), Positives = 51/118 (43%), Gaps = 11/118 (9%)

Query: 25  LPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELG 84
           +P    +LV +NP+ G GK  Q      Q +L   ++ F L L +       L +     
Sbjct: 371 VPNTHPLLVFVNPKSG-GKQGQRVLWKFQYILNPRQV-FNL-LKDGPEIGLRLFKDVPDS 427

Query: 85  RWDALVVMSGDGLMHEVVNGLMERPDWETA-IQKPLCSLPAGSGNALAASLNHYAGYE 141
           R   ++V  GDG     V  ++E  D     +  P+  LP G+GN LA  L    GYE
Sbjct: 428 R---ILVCGGDG----TVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYE 478


>gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
          Length = 735

 Score = 28.9 bits (63), Expect = 8.5
 Identities = 35/118 (29%), Positives = 51/118 (43%), Gaps = 11/118 (9%)

Query: 25  LPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELG 84
           +P    +LV +NP+ G GK  Q      Q +L   ++ F L L +       L +     
Sbjct: 371 VPNTHPLLVFVNPKSG-GKQGQRVLWKFQYILNPRQV-FNL-LKDGPEIGLRLFKDVPDS 427

Query: 85  RWDALVVMSGDGLMHEVVNGLMERPDWETA-IQKPLCSLPAGSGNALAASLNHYAGYE 141
           R   ++V  GDG     V  ++E  D     +  P+  LP G+GN LA  L    GYE
Sbjct: 428 R---ILVCGGDG----TVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYE 478


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.140    0.436 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,946,961
Number of Sequences: 37866
Number of extensions: 816622
Number of successful extensions: 2701
Number of sequences better than 10.0: 22
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 2681
Number of HSP's gapped (non-prelim): 27
length of query: 398
length of database: 18,247,518
effective HSP length: 104
effective length of query: 294
effective length of database: 14,309,454
effective search space: 4206979476
effective search space used: 4206979476
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.