Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 21071077
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21071077 dishevelled-associated activator of morphogenesis 1
[Homo sapiens]
(1078 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21071077 dishevelled-associated activator of morphogenesis 1 ... 2138 0.0
gi|40548415 dishevelled associated activator of morphogenesis 2 ... 1439 0.0
gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens] 424 e-118
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens] 422 e-118
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens] 422 e-118
gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens] 389 e-107
gi|52485606 formin-like 2 [Homo sapiens] 340 6e-93
gi|119120861 formin-like 3 isoform 2 [Homo sapiens] 326 8e-89
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens] 301 2e-81
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens] 301 2e-81
gi|119120874 formin-like 3 isoform 1 [Homo sapiens] 295 2e-79
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 294 3e-79
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 294 3e-79
gi|33356148 formin-like 1 [Homo sapiens] 277 3e-74
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 192 1e-48
gi|157168329 formin 1 [Homo sapiens] 192 2e-48
gi|145309324 FH2 domain containing 1 [Homo sapiens] 187 6e-47
gi|160707881 formin 2 [Homo sapiens] 178 2e-44
gi|58331242 formin homology 2 domain containing 3 [Homo sapiens] 140 6e-33
gi|118572599 formin homology 2 domain containing 1 [Homo sapiens] 117 8e-26
gi|14249316 hypothetical protein LOC84800 [Homo sapiens] 91 6e-18
gi|56549694 enabled homolog isoform a [Homo sapiens] 90 1e-17
gi|39930375 enabled homolog isoform b [Homo sapiens] 90 1e-17
gi|162329583 cleavage and polyadenylation specific factor 6, 68 ... 72 4e-12
gi|7706501 WW domain binding protein 11 [Homo sapiens] 71 5e-12
gi|150417989 cyclin K isoform 1 [Homo sapiens] 66 2e-10
gi|156071470 hyperpolarization activated cyclic nucleotide-gated... 65 3e-10
gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens] 65 3e-10
gi|153792074 proline rich 12 [Homo sapiens] 65 5e-10
gi|11386183 WAS protein family, member 2 [Homo sapiens] 64 6e-10
>gi|21071077 dishevelled-associated activator of morphogenesis 1 [Homo
sapiens]
Length = 1078
Score = 2139 bits (5541), Expect = 0.0
Identities = 1078/1078 (100%), Positives = 1078/1078 (100%)
Query: 1 MAPRKRGGRGISFIFCCFRNNDHPEITYRLRNDSNFALQTMEPALPMPPVEELDVMFSEL 60
MAPRKRGGRGISFIFCCFRNNDHPEITYRLRNDSNFALQTMEPALPMPPVEELDVMFSEL
Sbjct: 1 MAPRKRGGRGISFIFCCFRNNDHPEITYRLRNDSNFALQTMEPALPMPPVEELDVMFSEL 60
Query: 61 VDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEENKGATSWPEFYIDQLNSMAARKSLL 120
VDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEENKGATSWPEFYIDQLNSMAARKSLL
Sbjct: 61 VDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEENKGATSWPEFYIDQLNSMAARKSLL 120
Query: 121 ALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLDGLSCILNFLKTMDYETSESRIHTS 180
ALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLDGLSCILNFLKTMDYETSESRIHTS
Sbjct: 121 ALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLDGLSCILNFLKTMDYETSESRIHTS 180
Query: 181 LIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKV 240
LIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKV
Sbjct: 181 LIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKV 240
Query: 241 LQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDF 300
LQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDF
Sbjct: 241 LQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDF 300
Query: 301 RLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSA 360
RLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSA
Sbjct: 301 RLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSA 360
Query: 361 TQMFELTRKRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKGQ 420
TQMFELTRKRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKGQ
Sbjct: 361 TQMFELTRKRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKGQ 420
Query: 421 DPDSTPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEK 480
DPDSTPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEK
Sbjct: 421 DPDSTPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEK 480
Query: 481 EEMMQTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELSRRAVCASIPGGPSPGAPGGPF 540
EEMMQTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELSRRAVCASIPGGPSPGAPGGPF
Sbjct: 481 EEMMQTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELSRRAVCASIPGGPSPGAPGGPF 540
Query: 541 PSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPMGLALKK 600
PSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPMGLALKK
Sbjct: 541 PSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPMGLALKK 600
Query: 601 KSIPQPTNALKSFNWSKLPENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDFFV 660
KSIPQPTNALKSFNWSKLPENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDFFV
Sbjct: 601 KSIPQPTNALKSFNWSKLPENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDFFV 660
Query: 661 NSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQ 720
NSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQ
Sbjct: 661 NSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQ 720
Query: 721 EDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFK 780
EDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFK
Sbjct: 721 EDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFK 780
Query: 781 KKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQRGNAYGFKISSL 840
KKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQRGNAYGFKISSL
Sbjct: 781 KKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQRGNAYGFKISSL 840
Query: 841 NKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLR 900
NKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLR
Sbjct: 841 NKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLR 900
Query: 901 SGLKAVETELEYQKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHF 960
SGLKAVETELEYQKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHF
Sbjct: 901 SGLKAVETELEYQKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHF 960
Query: 961 GEEAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQRERERKM 1020
GEEAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQRERERKM
Sbjct: 961 GEEAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQRERERKM 1020
Query: 1021 RKAKENSEESGEFDDLVSALRSGEVFDKDLSKLKRNRKRITNQMTDSSRERPITKLNF 1078
RKAKENSEESGEFDDLVSALRSGEVFDKDLSKLKRNRKRITNQMTDSSRERPITKLNF
Sbjct: 1021 RKAKENSEESGEFDDLVSALRSGEVFDKDLSKLKRNRKRITNQMTDSSRERPITKLNF 1078
>gi|40548415 dishevelled associated activator of morphogenesis 2 [Homo
sapiens]
Length = 1067
Score = 1439 bits (3724), Expect = 0.0
Identities = 736/1090 (67%), Positives = 882/1090 (80%), Gaps = 35/1090 (3%)
Query: 1 MAPRKRGGRGISFIFCCFRNNDHPEITYRLRNDSNFALQTMEPALPMPPVEELDVMFSEL 60
MAPRKR G+ F+ CCF +D PEI R N LQ ME + P+P EEL++ F+EL
Sbjct: 1 MAPRKRSHHGLGFL-CCFGGSDIPEINLR----DNHPLQFMEFSSPIPNAEELNIRFAEL 55
Query: 61 VDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEE-NKGATSWPEFYIDQLNSMAARKSL 119
VDELDLTDK+REAMFALP EKKWQIYCSKKK+QE+ NK ATSWP++YID++NSMAA +SL
Sbjct: 56 VDELDLTDKNREAMFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYYIDRINSMAAMQSL 115
Query: 120 LALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLDGLSCILNFLKTMDYETSESRIHT 179
A ++EE E R++ +E LKTALRT+PMRFVTRFI+L+GL+C+LNFL++MD+ T ESRIHT
Sbjct: 116 YAFDEEETEMRNQVVEDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSMDHATCESRIHT 175
Query: 180 SLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKK 239
SLIGCIKALMNNSQGRAHVLA E+I+ IAQSL TEN KTKVAVLEILGAVCLVPGGHKK
Sbjct: 176 SLIGCIKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKK 235
Query: 240 VLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLD 299
VLQAMLHYQ YA+ERTRFQTL+N+LD+S GRYRDEV+LKTAIMSFINAVL+ GAG ++L+
Sbjct: 236 VLQAMLHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLE 295
Query: 300 FRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKS 359
FRLHLRYEFLMLGIQPVIDKLR+HEN+ LD+HLDFFEM+RNED+LE A+RF++VHIDTKS
Sbjct: 296 FRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKS 355
Query: 360 ATQMFELTRKRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKG 419
A+QMFEL K+L ++EAYP +S+LHHCLQMPYKR+G Q W LLDRI+QQIV+Q+++G
Sbjct: 356 ASQMFELIHKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERG 415
Query: 420 QDPDSTPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQE 479
DPD PLENFN+KN+V ML+NENEVKQW++QAEK RKEH EL +LE+KEREC+ KT E
Sbjct: 416 VDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLE 475
Query: 480 KEEMMQTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELSRRAVCASIPGGPSPGAPGGP 539
KEEMM+TLNKMK+KL +E+ E +Q + QVA+L AQL ELS V SP PGGP
Sbjct: 476 KEEMMRTLNKMKDKLARESQELRQARGQVAELVAQLSELSTGPV-------SSPPPPGGP 528
Query: 540 --FPSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGPPP-LGAIMPPPGAP--- 593
SS+ + LPPPPPP PPPPPPLPPGGPP PPG PP LG +P P P
Sbjct: 529 LTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPYPS 588
Query: 594 MGLALKKKSIPQPTNALKSFNWSKLPENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQ 653
+ L+KK +PQP++ LKSFNW KL E ++ GTVW EIDD +VF+ILDLED E+ FSAYQ
Sbjct: 589 SDVPLRKKRVPQPSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQ 648
Query: 654 RQQDFFVNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRA 713
R QKE + +D + KVKELSVIDGRRAQNC ILLS+LKLSN+EI++A
Sbjct: 649 RH----------QKELGSTEDIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQA 698
Query: 714 ILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQR 773
IL MDEQEDL KDMLEQLLKF+PEKSDIDLLEEHKHE++RMA+ADRFL+EMSRI+HYQQR
Sbjct: 699 ILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQR 758
Query: 774 LQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQRGNAY 833
LQ+L+FKKKF ER+AE KPKVEAI S E+ RS L+Q+LEV+LA GN+MNKGQRG AY
Sbjct: 759 LQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAY 818
Query: 834 GFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELD 893
GF+++SLNKIADTKSSID+NI+LLHYLI I+E +P +LN+ EL+ +P+AAKVN+ EL+
Sbjct: 819 GFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELE 878
Query: 894 KEISTLRSGLKAVETELEYQKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLF 953
KE+ LR GL+AVE LEYQ+ Q +P DKFV V+S FITV+SFSFS++ED L EA+D F
Sbjct: 879 KEVGNLRRGLRAVEV-LEYQRRQVREPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKF 937
Query: 954 TKAVKHFGEEAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQ 1013
KA+ HFGE K+QPDEFFGIFD FLQA SEA+Q+ E MR++KEEEERRARMEA LKEQ
Sbjct: 938 AKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQ 997
Query: 1014 RERERKMRKAK-----ENSEESGEFDDLVSALRSGEVFDKDLSKLKRNRKRITNQMTDSS 1068
RERER R+ K + EE GEFDDLVSALRSGEVFDKDL KLKR+RKR +Q + +
Sbjct: 998 RERERWQRQRKVLAAGSSLEEGGEFDDLVSALRSGEVFDKDLCKLKRSRKRSGSQALEVT 1057
Query: 1069 RERPITKLNF 1078
RER I +LN+
Sbjct: 1058 RERAINRLNY 1067
>gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
Length = 1193
Score = 424 bits (1089), Expect = e-118
Identities = 307/1084 (28%), Positives = 545/1084 (50%), Gaps = 119/1084 (10%)
Query: 32 NDSNFALQTMEPALPMPPVE-ELDVMFSELVDELDLTDKH----REAMFALPAEKKWQIY 86
+D + A M P P E EL +F +++++++L + RE F++ E Q
Sbjct: 100 SDCSAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYI 159
Query: 87 CSKKKDQEENKGATSWPEFYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPM 146
+ K + P+ +I +L +A + L+ +ESL+ +L + P+
Sbjct: 160 NTASKTGSLKRSRQISPQEFIHELKMGSADERLVTC-----------LESLRVSLTSNPV 208
Query: 147 RFVTRFIDLDGLSCILNFLKTMDYETSESRI----HTSLIGCIKALMNNSQGRAHVLAHS 202
+V F +GL +L+ L+ + + ++ +I C+KALMN G +++
Sbjct: 209 SWVESF-GHEGLGLLLDILEKLISGKIQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEE 267
Query: 203 ESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQTLIN 262
S++++A+++ + V+++L AVC+V G + +L+ +L A E +
Sbjct: 268 RSLSLLAKAVDPRHPNMMTDVVKLLSAVCIV--GEESILEEVLEALTSAGEEKKIDRFFC 325
Query: 263 DLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLRE 322
++ G + V L+ A M INA+++ + LDFRLH+R EF+ G++ ++ L+
Sbjct: 326 IVE---GLRHNSVQLQVACMQLINALVTSP---DDLDFRLHIRNEFMRCGLKEILPNLKC 379
Query: 323 HENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFMS 382
+N LD L F+ + ED E + R E + + A ++ + + + A +F+S
Sbjct: 380 IKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFIS 439
Query: 383 ILHHCLQMPYKRSGNTV--QYWLLLDRIIQQIVIQNDKGQDPDSTPLE--NFNIKNVVRM 438
IL H L + R+ + QY+ L+D + QIV+ D G DPD T + + ++ V +
Sbjct: 440 ILQHLLLI---RNDYFIRQQYFKLIDECVSQIVLHRD-GMDPDFTYRKRLDLDLTQFVDI 495
Query: 439 LVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKET 498
+++ ++++++E+A +EL +K EK E
Sbjct: 496 CIDQAKLEEFEEKA-------SELYKKFEK----------------------------EF 520
Query: 499 TEHKQVKQQVADLTAQLHELSRRAVCASIPGGPSPGAPGGPFPSSVPG----SLLPPPPP 554
T+H++ + ++ A+++EL G P P P S G S LPPPPP
Sbjct: 521 TDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPP 580
Query: 555 PPLPGGMLPPPPPPLPP---------GGPPPPPGPPPLGAI-----MPPPGAPMGLALKK 600
P GG+ PPPPPP PP GP PP PPPLG + P P P GL KK
Sbjct: 581 LPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPP--PPPLGFLGGQNSPPLPILPFGLKPKK 638
Query: 601 KSIPQPTNALKSFNWSKL-PENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDFF 659
+ +P +++ NW K+ P E W ++++ K + L LE TF Q++
Sbjct: 639 EF--KPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKE---- 692
Query: 660 VNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDE 719
++E + I++ S K K+KEL +D + AQN +I LS ++ +EI+ IL +DE
Sbjct: 693 ------RREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDE 746
Query: 720 QEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYF 779
L + M++ L+K +P++ ++ L + K E + + ++F+ MS + + RL ++ F
Sbjct: 747 TR-LAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILF 805
Query: 780 KKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQR-GNAYGFKIS 838
K +F E+V +KP + A+ + EE+ +S + +LLE+VL GNYMN G R +GF +S
Sbjct: 806 KLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLS 865
Query: 839 SLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEIST 898
SL K+ DTKS+ D+ TLLH+L+ I E KYP +LN ++L + +A+KV++ L+K +
Sbjct: 866 SLCKLKDTKSA-DQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQ 924
Query: 899 LRSGLKAVETELEYQKSQPPQP-GDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAV 957
+ L+ +E ELE PP+ DKFV+ +S+F+ A + + L + L+ +
Sbjct: 925 MGRQLQQLEKELE--TFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSII 982
Query: 958 KHFGEEAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQRERE 1017
++ + K+ ++F + F +A +EN +++ EE+E+R R+ +L E+ E
Sbjct: 983 GYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIK-KREAEEKEKRVRIAKELAERERLE 1041
Query: 1018 RKMRK-----AKENSEESGEFDDLVSALRSGEVFDKDLSKLKRNRKRITNQMTDSSRERP 1072
R+ +K K +E+G D+L+ AL+SG F +D K K + ++ S +RP
Sbjct: 1042 RQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAF-RDRRKRTPMPKDVRQSLSPMS-QRP 1099
Query: 1073 ITKL 1076
+ K+
Sbjct: 1100 VLKV 1103
>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
Length = 1096
Score = 422 bits (1086), Expect = e-118
Identities = 315/1066 (29%), Positives = 535/1066 (50%), Gaps = 107/1066 (10%)
Query: 33 DSNFALQTMEPALPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKD 92
DS A+ A P+ L++ E+ LDL +K E M L EKK +
Sbjct: 79 DSQVAMSEFPAAQPLYDERSLNLSEKEV---LDLFEKMMEDM-NLNEEKKAPL------- 127
Query: 93 QEENKGATSWPEFYIDQLNSMAARKSLLALEKE----------------EEEERSKTIES 136
NK T+ E + +++ A L + E +E+ +ES
Sbjct: 128 --RNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLLNCLES 185
Query: 137 LKTALRTKPMRFVTRFIDLDGLSCILNFLKTM----DYETSESRIHTSLIGCIKALMNNS 192
L+ +L + P+ +V F +GL +L+ L+ + E + + LI C+KA MNN
Sbjct: 186 LRVSLTSNPVSWVNNF-GHEGLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAFMNNK 244
Query: 193 QGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQKYAS 252
G +L S+ ++A+++ + +++IL A+C+V G + +L +L A+
Sbjct: 245 FGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIV--GEENILDKLLGAITTAA 302
Query: 253 ERT---RFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFL 309
ER RF ++ L+ ++ + L+ A M FINA+++ LDFR+HLR EFL
Sbjct: 303 ERNNRERFSPIVEGLEN-----QEALQLQVACMQFINALVTSPY---ELDFRIHLRNEFL 354
Query: 310 MLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRK 369
G++ ++ L+E EN LD L F+ + +D E + R + + +++ L
Sbjct: 355 RSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYN 414
Query: 370 RLTHSEAYPHFMSILHHCLQMP---YKRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTP 426
L + A +F+SIL H L + Y R QY+ +++ + QIV+ + G DPD
Sbjct: 415 MLKDTAAENYFLSILQHFLLIRNDYYIRP----QYYKIIEECVSQIVL-HCSGMDPDFKY 469
Query: 427 LENFNIK--NVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMM 484
+ +I +++ VN+ +V++ +++A + K+ +E + ++E
Sbjct: 470 RQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDE--------------EFTARQEAQ 515
Query: 485 QTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELSRRAVCASIPG-GPSPGAPGGPFPSS 543
L K EK+++ E +Q++ Q A + + + +PG GP P P P P
Sbjct: 516 AELQKRDEKIKELEAEIQQLRTQ-AQVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGG 574
Query: 544 VPGSLLPPPPPPPLPG--GMLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPMGL--ALK 599
P PPPPPPLPG G+ PPPPPPL GGPPPPP PLG + PPPG + L +K
Sbjct: 575 AP----LPPPPPPLPGMMGIPPPPPPPLLFGGPPPPP---PLGGVPPPPGISLNLPYGMK 627
Query: 600 KKSIPQPTNALKSFNWSKLPENKL-EGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDF 658
+K + +P ++K NWSK+ +L E W + + K F+ DL + +
Sbjct: 628 QKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDK-FENPDL---------FAKLALN 677
Query: 659 FVNSNSKQKEADAIDD--TLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILT 716
F QK A+A+++ T +K KVKEL ++D + AQN +I L ++ ++I+ IL
Sbjct: 678 FATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILE 737
Query: 717 MDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQS 776
++E + L + +++ L+K +PE+ ++ L E K+E D + + ++F MS + Q RL S
Sbjct: 738 VNE-DMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSS 796
Query: 777 LYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQR-GNAYGF 835
+ FK F E + +KP + A+ EE+ +S + +LLE+VL GNYMN G R + GF
Sbjct: 797 ILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGF 856
Query: 836 KISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKE 895
KI+ L KI DTKS+ D+ TLLH++ I E KY +L EEL + A+KV+ L
Sbjct: 857 KINFLCKIRDTKSA-DQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSN 915
Query: 896 ISTLRSGLKAVETELEYQKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTK 955
++++ + +E +++ + Q DKFV ++ F A + + + L+
Sbjct: 916 LASMEQQIVHLERDIK-KFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYEN 974
Query: 956 AVKHFGEEAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQRE 1015
++F ++ + +EFFG + F EA +EN N R++ EE+ RRA++ + EQ +
Sbjct: 975 LGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVREN-NKRREMEEKTRRAKLAKEKAEQEK 1033
Query: 1016 RERKMRKAK-----ENSEESGEFDDLVSALRSGEVFDKDLSKLKRN 1056
ER+ +K + + +E+G D+L+ AL+SG F ++ RN
Sbjct: 1034 LERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRN 1079
>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
Length = 1101
Score = 422 bits (1086), Expect = e-118
Identities = 315/1066 (29%), Positives = 535/1066 (50%), Gaps = 107/1066 (10%)
Query: 33 DSNFALQTMEPALPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKD 92
DS A+ A P+ L++ E+ LDL +K E M L EKK +
Sbjct: 79 DSQVAMSEFPAAQPLYDERSLNLSEKEV---LDLFEKMMEDM-NLNEEKKAPL------- 127
Query: 93 QEENKGATSWPEFYIDQLNSMAARKSLLALEKE----------------EEEERSKTIES 136
NK T+ E + +++ A L + E +E+ +ES
Sbjct: 128 --RNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLLNCLES 185
Query: 137 LKTALRTKPMRFVTRFIDLDGLSCILNFLKTM----DYETSESRIHTSLIGCIKALMNNS 192
L+ +L + P+ +V F +GL +L+ L+ + E + + LI C+KA MNN
Sbjct: 186 LRVSLTSNPVSWVNNF-GHEGLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAFMNNK 244
Query: 193 QGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQKYAS 252
G +L S+ ++A+++ + +++IL A+C+V G + +L +L A+
Sbjct: 245 FGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIV--GEENILDKLLGAITTAA 302
Query: 253 ERT---RFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFL 309
ER RF ++ L+ ++ + L+ A M FINA+++ LDFR+HLR EFL
Sbjct: 303 ERNNRERFSPIVEGLEN-----QEALQLQVACMQFINALVTSPY---ELDFRIHLRNEFL 354
Query: 310 MLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRK 369
G++ ++ L+E EN LD L F+ + +D E + R + + +++ L
Sbjct: 355 RSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYN 414
Query: 370 RLTHSEAYPHFMSILHHCLQMP---YKRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTP 426
L + A +F+SIL H L + Y R QY+ +++ + QIV+ + G DPD
Sbjct: 415 MLKDTAAENYFLSILQHFLLIRNDYYIRP----QYYKIIEECVSQIVL-HCSGMDPDFKY 469
Query: 427 LENFNIK--NVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMM 484
+ +I +++ VN+ +V++ +++A + K+ +E + ++E
Sbjct: 470 RQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDE--------------EFTARQEAQ 515
Query: 485 QTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELSRRAVCASIPG-GPSPGAPGGPFPSS 543
L K EK+++ E +Q++ Q A + + + +PG GP P P P P
Sbjct: 516 AELQKRDEKIKELEAEIQQLRTQ-AQVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGG 574
Query: 544 VPGSLLPPPPPPPLPG--GMLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPMGL--ALK 599
P PPPPPPLPG G+ PPPPPPL GGPPPPP PLG + PPPG + L +K
Sbjct: 575 AP----LPPPPPPLPGMMGIPPPPPPPLLFGGPPPPP---PLGGVPPPPGISLNLPYGMK 627
Query: 600 KKSIPQPTNALKSFNWSKLPENKL-EGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDF 658
+K + +P ++K NWSK+ +L E W + + K F+ DL + +
Sbjct: 628 QKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDK-FENPDL---------FAKLALN 677
Query: 659 FVNSNSKQKEADAIDD--TLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILT 716
F QK A+A+++ T +K KVKEL ++D + AQN +I L ++ ++I+ IL
Sbjct: 678 FATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILE 737
Query: 717 MDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQS 776
++E + L + +++ L+K +PE+ ++ L E K+E D + + ++F MS + Q RL S
Sbjct: 738 VNE-DMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSS 796
Query: 777 LYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQR-GNAYGF 835
+ FK F E + +KP + A+ EE+ +S + +LLE+VL GNYMN G R + GF
Sbjct: 797 ILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGF 856
Query: 836 KISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKE 895
KI+ L KI DTKS+ D+ TLLH++ I E KY +L EEL + A+KV+ L
Sbjct: 857 KINFLCKIRDTKSA-DQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSN 915
Query: 896 ISTLRSGLKAVETELEYQKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTK 955
++++ + +E +++ + Q DKFV ++ F A + + + L+
Sbjct: 916 LASMEQQIVHLERDIK-KFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYEN 974
Query: 956 AVKHFGEEAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQRE 1015
++F ++ + +EFFG + F EA +EN N R++ EE+ RRA++ + EQ +
Sbjct: 975 LGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVREN-NKRREMEEKTRRAKLAKEKAEQEK 1033
Query: 1016 RERKMRKAK-----ENSEESGEFDDLVSALRSGEVFDKDLSKLKRN 1056
ER+ +K + + +E+G D+L+ AL+SG F ++ RN
Sbjct: 1034 LERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRN 1079
>gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
Length = 849
Score = 389 bits (998), Expect = e-107
Identities = 267/908 (29%), Positives = 467/908 (51%), Gaps = 98/908 (10%)
Query: 199 LAHSESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQ 258
++ S++++A+++ + V+++L AVC+V G + +L+ +L A E +
Sbjct: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIV--GEESILEEVLEALTSAGEEKKID 58
Query: 259 TLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVID 318
++ G + V L+ A M INA+++ + LDFRLH+R EF+ G++ ++
Sbjct: 59 RFFCIVE---GLRHNSVQLQVACMQLINALVTSP---DDLDFRLHIRNEFMRCGLKEILP 112
Query: 319 KLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYP 378
L+ +N LD L F+ + ED E + R E + + A ++ + + + A
Sbjct: 113 NLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEG 172
Query: 379 HFMSILHHCLQMPYKRSGNTV--QYWLLLDRIIQQIVIQNDKGQDPDSTPLE--NFNIKN 434
+F+SIL H L + R+ + QY+ L+D + QIV+ D G DPD T + + ++
Sbjct: 173 YFISILQHLLLI---RNDYFIRQQYFKLIDECVSQIVLHRD-GMDPDFTYRKRLDLDLTQ 228
Query: 435 VVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKL 494
V + +++ ++++++E+A +EL +K EK
Sbjct: 229 FVDICIDQAKLEEFEEKA-------SELYKKFEK-------------------------- 255
Query: 495 EKETTEHKQVKQQVADLTAQLHELSRRAVCASIPGGPSPGAPGGPFPSSVPG----SLLP 550
E T+H++ + ++ A+++EL G P P P S G S LP
Sbjct: 256 --EFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALP 313
Query: 551 PPPPPPLPGGMLPPPPPPLPP---------GGPPPPPGPPPLGAI-----MPPPGAPMGL 596
PPPP P GG+ PPPPPP PP GP PP PPPLG + P P P GL
Sbjct: 314 PPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPP--PPPLGFLGGQNSPPLPILPFGL 371
Query: 597 ALKKKSIPQPTNALKSFNWSKL-PENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQ 655
KK+ +P +++ NW K+ P E W ++++ K + L LE TF Q++
Sbjct: 372 KPKKEF--KPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKE 429
Query: 656 QDFFVNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAIL 715
++E + I++ S K K+KEL +D + AQN +I LS ++ +EI+ IL
Sbjct: 430 ----------RREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMIL 479
Query: 716 TMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQ 775
+DE L + M++ L+K +P++ ++ L + K E + + ++F+ MS + + RL
Sbjct: 480 EVDETR-LAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLS 538
Query: 776 SLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQR-GNAYG 834
++ FK +F E+V +KP + A+ + EE+ +S + +LLE+VL GNYMN G R +G
Sbjct: 539 AILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFG 598
Query: 835 FKISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDK 894
F +SSL K+ DTKS+ D+ TLLH+L+ I E KYP +LN ++L + +A+KV++ L+K
Sbjct: 599 FNLSSLCKLKDTKSA-DQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEK 657
Query: 895 EISTLRSGLKAVETELEYQKSQPPQP-GDKFVSVVSQFITVASFSFSDVEDLLAEAKDLF 953
+ + L+ +E ELE PP+ DKFV+ +S+F+ A + + L + L+
Sbjct: 658 NLRQMGRQLQQLEKELE--TFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLY 715
Query: 954 TKAVKHFGEEAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQ 1013
+ ++ + K+ ++F + F +A +EN +++ EE+E+R R+ +L E+
Sbjct: 716 QSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIK-KREAEEKEKRVRIAKELAER 774
Query: 1014 RERERKMRK-----AKENSEESGEFDDLVSALRSGEVFDKDLSKLKRNRKRITNQMTDSS 1068
ER+ +K K +E+G D+L+ AL+SG F +D K K + ++ S
Sbjct: 775 ERLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAF-RDRRKRTPMPKDVRQSLSPMS 833
Query: 1069 RERPITKL 1076
+RP+ K+
Sbjct: 834 -QRPVLKV 840
>gi|52485606 formin-like 2 [Homo sapiens]
Length = 1092
Score = 340 bits (871), Expect = 6e-93
Identities = 264/912 (28%), Positives = 443/912 (48%), Gaps = 110/912 (12%)
Query: 165 LKTMDYETSESRIHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVL 224
LK + + +H ++ C++A+MN G V++H ++N IA SL+ +N +TK VL
Sbjct: 209 LKNSRLVSKKDDVHVCIM-CLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVL 267
Query: 225 EILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSF 284
E+L AVCLV GGH+ +L A ++++ E+ RF+ L+ + + A M F
Sbjct: 268 ELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNED----NNIDFMVASMQF 323
Query: 285 INAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDEL 344
IN V+ VE ++FR+HL+YEF LG+ +DKL+ E+ L + + L N
Sbjct: 324 INIVVH---SVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAY--LDNV--- 375
Query: 345 EFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLL 404
D + + E L E +S L LQ + + +
Sbjct: 376 ----------FDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVE--- 422
Query: 405 LDRIIQQIVIQNDKGQDPDSTPLENFNIK-NVVRMLVNENEVKQWKEQAEKMRKEHNELQ 463
+++ ++Q +K D ++ N + + +R +V KE+ E ++++ + L+
Sbjct: 423 ----LEKQLMQRNKELDVVREIYKDANTQVHTLRKMV--------KEKEEAIQRQ-STLE 469
Query: 464 QKLEKKERECDAKTQEKEE----MMQTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELS 519
+K+ + E++ K Q+K + ++ + + E V +
Sbjct: 470 KKIHELEKQGTIKIQKKGDGDIAILPVVASGTLSMGSEVVAGNSVGPTMG---------- 519
Query: 520 RRAVCASIPGGPSPGAPGGPFPSSVP-GSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPP 578
A +P P P P P +V G + PP PPPP P PPPPPP PP PPP P
Sbjct: 520 -AASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPP---PPPPPPPPPPPPPPLP 575
Query: 579 GP-----------PPLGAIMPPPGAP-------MGLALKKKSIPQPTN-ALKSFNWSKLP 619
GP PPL + P PG GLA K P T + FNW L
Sbjct: 576 GPAAETVPAPPLAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALK 635
Query: 620 ENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDFFVNSNSKQKEADAIDDTLSSK 679
N++ GTV+ EIDD ++ + L++++ E F + Q S+SKQK I S+K
Sbjct: 636 PNQINGTVFNEIDDERILEDLNVDEFEEIFKT-KAQGPAIDLSSSKQK----IPQKGSNK 690
Query: 680 LKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKS 739
+++++ RA+N I L + + DEI +AI D + LP D +E L++F+P ++
Sbjct: 691 -----VTLLEANRAKNLAITLRKAGKTADEICKAIHVFD-LKTLPVDFVECLMRFLPTEN 744
Query: 740 DIDLL---EEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEA 796
++ +L E + L+ ++ DRF+ + S+I Q++ + F FAE + + P++ A
Sbjct: 745 EVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHA 804
Query: 797 IRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSSIDKNITL 856
I + S + S LK++LE++LA GNYMN +RG YGFK+ SL+ + DTKS+ D+ TL
Sbjct: 805 IIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKST-DRKQTL 863
Query: 857 LHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKSQ 916
LHY+ +V+ KY V EL + +AA V++ + ++ L+ G+ + E
Sbjct: 864 LHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHN 923
Query: 917 PPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGIF 976
+++ +FI ++D A+D F VK+FGE P FF +F
Sbjct: 924 ---------TLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVF 974
Query: 977 DQFLQAVSEAKQENENMRKKKEEEERRARMEAQ-LKEQRERERKMRKAKENSEESGEFDD 1035
+F++A +A++ENE +RKK+E+ +E + L EQ++ + K+K +E
Sbjct: 975 VRFVKAYKQAEEENE-LRKKQEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQE------ 1027
Query: 1036 LVSALRSGEVFD 1047
L++ LR +V D
Sbjct: 1028 LIAELRRRQVKD 1039
Score = 53.1 bits (126), Expect = 1e-06
Identities = 36/156 (23%), Positives = 74/156 (47%), Gaps = 13/156 (8%)
Query: 34 SNFALQTMEPALPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKDQ 93
++F + LPMP EL+ F+ +++ ++L + EKKW++ C +++ Q
Sbjct: 12 TDFRAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQ 71
Query: 94 EENKGATSWPEFYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFI 153
+N P YI +L + +E ++ + L+ +LRT + +V F+
Sbjct: 72 VKNP-----PHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFL 126
Query: 154 DLD--GLSCILNFLK------TMDYETSESRIHTSL 181
+ + GL ++ +L T D+E+ ES + +S+
Sbjct: 127 NEENKGLDVLVEYLSFAQYAVTFDFESVESTVESSV 162
>gi|119120861 formin-like 3 isoform 2 [Homo sapiens]
Length = 976
Score = 326 bits (835), Expect = 8e-89
Identities = 274/1047 (26%), Positives = 480/1047 (45%), Gaps = 174/1047 (16%)
Query: 45 LPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEENKGATSWPE 104
+PMP EL+ F+ ++ ++L + EKKW + C +++ Q +N P
Sbjct: 26 MPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNP-----PH 80
Query: 105 FYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLD--GLSCIL 162
YI +L S + +E +K + L+ +LRT + +V F++ + GL ++
Sbjct: 81 TYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLV 140
Query: 163 NFLK----TMDYETSESR--------------IHTSLIGCIKALMNNSQGRAHVLAHSES 204
++L ++ Y T R +H ++ C++A+MN G V++H +
Sbjct: 141 DYLSFAQCSVMYSTLPGRRALKNSRLVSQKDDVHVCIL-CLRAIMNYQYGFNLVMSHPHA 199
Query: 205 INVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQTLINDL 264
+N IA SL+ +N +TK VLE+L AVCLV GGH+ +L A ++++ E RF+ L+
Sbjct: 200 VNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLME-- 257
Query: 265 DKSTGRYRDE---VSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLR 321
+R+E + A M FIN V+ VE ++FR+HL+YEF LG++ + K R
Sbjct: 258 -----YFRNEDSNIDFMVACMQFINIVVH---SVEDMNFRVHLQYEFTKLGLEEFLQKSR 309
Query: 322 EHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFM 381
E+ E L+ + + F++ + + T+ L + E H
Sbjct: 310 HTES----------EKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKV----EELEEHVS 355
Query: 382 SILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTPLENFNIK-NVVRMLV 440
+ L + + + +++ ++Q +K + EN + + + +R L+
Sbjct: 356 HLTEKLLDLENENMMRVAE--------LEKQLLQREKELESIKETYENTSHQVHTLRRLI 407
Query: 441 NENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTE 500
E KE+A + R + LE + E A+ E L++ + +
Sbjct: 408 KE------KEEAFQRRCHLEPNVRGLESVDSEALARVGPAE-----LSEGMPPSDLDLLA 456
Query: 501 HKQVKQQVADLTAQLHELSRRAVCASIPGGPSPGAPGGPFPSSVPGSLLPPPPPPPLPGG 560
++V L P P+P P P P +P PP PPLPG
Sbjct: 457 PAPPPEEVLPL----------------PPPPAPPLP--PPPPPLPDKC---PPAPPLPGA 495
Query: 561 MLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPMGLALKKKSIPQPTNA---LKSFNWSK 617
P + + L I +P L FNW+
Sbjct: 496 ----------------------------APSVVLTVGLSAIRIKKPIKTKFRLPVFNWTA 527
Query: 618 LPENKLEGTVWTEIDDTKVFKILDLEDLERTF--SAYQRQQDFFVNSNSKQKEADAIDDT 675
L N++ GTV++E+DD K+ + LDL+ E F A D + N ++A
Sbjct: 528 LKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKA------ 581
Query: 676 LSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFV 735
++++++ RA+N I L + S +EI RAI T D Q LP D +E L++F+
Sbjct: 582 ------ASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQ-TLPVDFVECLMRFL 634
Query: 736 PEKSDIDLLEEHKHE---LDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKP 792
P ++++ LL +++ E L+ +A DRF+ S++ QR+ + F F + + + P
Sbjct: 635 PTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTP 694
Query: 793 KVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSSIDK 852
++ AI + S V S LKQ+LE++LA GNYMN +RG YGFK+ SL+ + DTKS+ D+
Sbjct: 695 QLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKST-DR 753
Query: 853 NITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEY 912
+TLLH++ V+ KYP + N EL + +AA V++ + ++ L G++ + E
Sbjct: 754 KMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSI 813
Query: 913 QKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEF 972
+ SV+ F++ ++ A++ + V++FGE P F
Sbjct: 814 HDN----------SVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVF 863
Query: 973 FGIFDQFLQAVSEAKQENENMRKKKEEEERR-------ARMEAQLKEQRER--------E 1017
F +F +F+++ EA+QENE RKK+EE R +++A+ QR + E
Sbjct: 864 FPVFVRFIRSYKEAEQENE-ARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAE 922
Query: 1018 RKMRKAKEN----SEESGEFDDLVSAL 1040
+ R+AKE+ + G +D+++ L
Sbjct: 923 LRRRQAKEHRPVYEGKDGTIEDIITGL 949
>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
Length = 1240
Score = 301 bits (771), Expect = 2e-81
Identities = 254/966 (26%), Positives = 440/966 (45%), Gaps = 116/966 (12%)
Query: 148 FVTRFIDLDGLSCILNFLKTMD----YETSESRIHTSLIGCIKALMNNSQGRAHVLAHSE 203
++ +F++ GL +L L + S++ + + + C++A+MN+ QG ++L++
Sbjct: 64 WMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQG 123
Query: 204 SINVIAQSLSTENIKTKVAVLEILGAVCLV-PGGHKKVLQAMLHYQKYASERTRFQTLIN 262
+ ++Q+L T N+ K V E+L A+C+ P GH L A+ HY+ S++ RF ++N
Sbjct: 124 YVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMN 183
Query: 263 DLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLRE 322
+L S D V ++S INAV+ G E L R LR EF+ L + V+ +LR+
Sbjct: 184 ELSGS-----DNVPYVVTLLSVINAVI---LGPEDLRARTQLRNEFIGLQLLDVLARLRD 235
Query: 323 HENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFMS 382
E++ L L+ FE + EDE E + +D S ++F +++ S +S
Sbjct: 236 LEDADLLIQLEAFEEAKAEDEEELLRVSG--GVDMSSHQEVFASLFHKVSCSPVSAQLLS 293
Query: 383 ILHHCLQM-PYKRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTPLENFNIKNVVRMLVN 441
+L L + P RS + W L+ ++ + V+ Q+ ++ VV L++
Sbjct: 294 VLQGLLHLEPTLRSSQLL--WEALESLVNRAVLLASDAQE--------CTLEEVVERLLS 343
Query: 442 ENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEH 501
+ + + + K H +Q L++ +R + + + E +H
Sbjct: 344 V----KGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDH 399
Query: 502 KQVKQ-----QVADLTAQ----------------------------LHELSRRAVCASIP 528
Q + Q L Q L + +A+ + P
Sbjct: 400 AQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPP 459
Query: 529 GGPSPGA-----PGGPFPSSVPGSL-LPPPPPPPLPGGMLPPPPPPLPPG---GPPPPPG 579
P PG P P P +PGS PPPPPPLPG PPPPPPL PG GPPPPP
Sbjct: 460 PPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPP- 518
Query: 580 PPPLGAIMPPP---------------GAPMGLALKKKSIPQPTNALKSFNWSKLPEN--K 622
PP L PP G + + PT +K NW KLP N +
Sbjct: 519 PPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAR 578
Query: 623 LEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDFFVNSNSKQKEADAIDDTLSSKLKV 682
++W + D E +E FS+ +R F +K KE + ++ +
Sbjct: 579 EHNSMWASLSSP------DAEAVEPDFSSIERLFSF---PAAKPKEPTMVAPR--ARKEP 627
Query: 683 KELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDID 742
KE++ +D +++ N NI L + K SN+E+ A++ + ++L+QLLK +PEK +I+
Sbjct: 628 KEITFLDAKKSLNLNIFLKQFKCSNEEVA-AMIRAGDTTKFDVEVLKQLLKLLPEKHEIE 686
Query: 743 LLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSE 802
L E ++A AD F + I YQ R++ + + A + V+PK + + + E
Sbjct: 687 NLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACE 746
Query: 803 EVFRSGALKQLLEVVLAFGNYMNKGQR-GNAYGFKISSLNKIADTKSSIDKNITLLHYLI 861
+ S L +++L GN++N G G+A GFKIS+L K+ +TKS +TLLH+++
Sbjct: 747 SLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQ-QNRVTLLHHVL 805
Query: 862 TIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKSQPPQPG 921
E +P +L L +L QAA +N+ + E S+ + K +ETE + S
Sbjct: 806 EEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASS--NLKKLLETERKVSASVA---- 859
Query: 922 DKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGIF----D 977
+ ++ + + +F +++L + + + E+A ++ ++ F D
Sbjct: 860 -EVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRD 918
Query: 978 QFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQRERERKMRKAKENSEESGEFDDLV 1037
FL+A+ E K E K + +++ A EA+ + + E + +RK EE D L+
Sbjct: 919 LFLRALKENKDRKEQAAKAERRKQQLAEEEAR-RPRGEDGKPVRKGPGKQEEVCVIDALL 977
Query: 1038 SALRSG 1043
+ +R G
Sbjct: 978 ADIRKG 983
>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
Length = 1249
Score = 301 bits (771), Expect = 2e-81
Identities = 254/966 (26%), Positives = 440/966 (45%), Gaps = 116/966 (12%)
Query: 148 FVTRFIDLDGLSCILNFLKTMD----YETSESRIHTSLIGCIKALMNNSQGRAHVLAHSE 203
++ +F++ GL +L L + S++ + + + C++A+MN+ QG ++L++
Sbjct: 64 WMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQG 123
Query: 204 SINVIAQSLSTENIKTKVAVLEILGAVCLV-PGGHKKVLQAMLHYQKYASERTRFQTLIN 262
+ ++Q+L T N+ K V E+L A+C+ P GH L A+ HY+ S++ RF ++N
Sbjct: 124 YVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMN 183
Query: 263 DLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLRE 322
+L S D V ++S INAV+ G E L R LR EF+ L + V+ +LR+
Sbjct: 184 ELSGS-----DNVPYVVTLLSVINAVI---LGPEDLRARTQLRNEFIGLQLLDVLARLRD 235
Query: 323 HENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFMS 382
E++ L L+ FE + EDE E + +D S ++F +++ S +S
Sbjct: 236 LEDADLLIQLEAFEEAKAEDEEELLRVSG--GVDMSSHQEVFASLFHKVSCSPVSAQLLS 293
Query: 383 ILHHCLQM-PYKRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTPLENFNIKNVVRMLVN 441
+L L + P RS + W L+ ++ + V+ Q+ ++ VV L++
Sbjct: 294 VLQGLLHLEPTLRSSQLL--WEALESLVNRAVLLASDAQE--------CTLEEVVERLLS 343
Query: 442 ENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEH 501
+ + + + K H +Q L++ +R + + + E +H
Sbjct: 344 V----KGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDH 399
Query: 502 KQVKQ-----QVADLTAQ----------------------------LHELSRRAVCASIP 528
Q + Q L Q L + +A+ + P
Sbjct: 400 AQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPP 459
Query: 529 GGPSPGA-----PGGPFPSSVPGSL-LPPPPPPPLPGGMLPPPPPPLPPG---GPPPPPG 579
P PG P P P +PGS PPPPPPLPG PPPPPPL PG GPPPPP
Sbjct: 460 PPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPP- 518
Query: 580 PPPLGAIMPPP---------------GAPMGLALKKKSIPQPTNALKSFNWSKLPEN--K 622
PP L PP G + + PT +K NW KLP N +
Sbjct: 519 PPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAR 578
Query: 623 LEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDFFVNSNSKQKEADAIDDTLSSKLKV 682
++W + D E +E FS+ +R F +K KE + ++ +
Sbjct: 579 EHNSMWASLSSP------DAEAVEPDFSSIERLFSF---PAAKPKEPTMVAPR--ARKEP 627
Query: 683 KELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDID 742
KE++ +D +++ N NI L + K SN+E+ A++ + ++L+QLLK +PEK +I+
Sbjct: 628 KEITFLDAKKSLNLNIFLKQFKCSNEEVA-AMIRAGDTTKFDVEVLKQLLKLLPEKHEIE 686
Query: 743 LLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSE 802
L E ++A AD F + I YQ R++ + + A + V+PK + + + E
Sbjct: 687 NLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACE 746
Query: 803 EVFRSGALKQLLEVVLAFGNYMNKGQR-GNAYGFKISSLNKIADTKSSIDKNITLLHYLI 861
+ S L +++L GN++N G G+A GFKIS+L K+ +TKS +TLLH+++
Sbjct: 747 SLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQ-QNRVTLLHHVL 805
Query: 862 TIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKSQPPQPG 921
E +P +L L +L QAA +N+ + E S+ + K +ETE + S
Sbjct: 806 EEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASS--NLKKLLETERKVSASVA---- 859
Query: 922 DKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGIF----D 977
+ ++ + + +F +++L + + + E+A ++ ++ F D
Sbjct: 860 -EVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRD 918
Query: 978 QFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQRERERKMRKAKENSEESGEFDDLV 1037
FL+A+ E K E K + +++ A EA+ + + E + +RK EE D L+
Sbjct: 919 LFLRALKENKDRKEQAAKAERRKQQLAEEEAR-RPRGEDGKPVRKGPGKQEEVCVIDALL 977
Query: 1038 SALRSG 1043
+ +R G
Sbjct: 978 ADIRKG 983
>gi|119120874 formin-like 3 isoform 1 [Homo sapiens]
Length = 1027
Score = 295 bits (755), Expect = 2e-79
Identities = 243/907 (26%), Positives = 420/907 (46%), Gaps = 149/907 (16%)
Query: 165 LKTMDYETSESRIHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVL 224
LK + + +H ++ C++A+MN G V++H ++N IA SL+ +N +TK VL
Sbjct: 212 LKNSRLVSQKDDVHVCIL-CLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVL 270
Query: 225 EILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDE---VSLKTAI 281
E+L AVCLV GGH+ +L A ++++ E RF+ L+ +R+E + A
Sbjct: 271 ELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLME-------YFRNEDSNIDFMVAC 323
Query: 282 MSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNE 341
M FIN V+ VE ++FR+HL+YEF LG++ + K R E+ E L+ +
Sbjct: 324 MQFINIVVH---SVEDMNFRVHLQYEFTKLGLEEFLQKSRHTES----------EKLQVQ 370
Query: 342 DELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQY 401
+ F++ + + T+ L + E H + L + + +
Sbjct: 371 IQAYLDNVFDVGGLLEDAETKNVALEKV----EELEEHVSHLTEKLLDLENENMMRVAE- 425
Query: 402 WLLLDRIIQQIVIQNDKGQDPDSTPLENFNIK-NVVRMLVNENEVKQWKEQAEKMRKEHN 460
+++ ++Q +K + EN + + + +R L+ E KE+A + R
Sbjct: 426 -------LEKQLLQREKELESIKETYENTSHQVHTLRRLIKE------KEEAFQRRCHLE 472
Query: 461 ELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELSR 520
+ LE + E A+ E L++ + + ++V L
Sbjct: 473 PNVRGLESVDSEALARVGPAE-----LSEGMPPSDLDLLAPAPPPEEVLPL--------- 518
Query: 521 RAVCASIPGGPSPGAPGGPFPSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGP 580
P P+P P P P +P PP PPLPG
Sbjct: 519 -------PPPPAPPLP--PPPPPLPDKC---PPAPPLPGA-------------------- 546
Query: 581 PPLGAIMPPPGAPMGLALKKKSIPQPTNA---LKSFNWSKLPENKLEGTVWTEIDDTKVF 637
P + + L I +P L FNW+ L N++ GTV++E+DD K+
Sbjct: 547 --------APSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKIL 598
Query: 638 KILDLEDLERTF--SAYQRQQDFFVNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQN 695
+ LDL+ E F A D + N ++A ++++++ RA+N
Sbjct: 599 EDLDLDKFEELFKTKAQGPALDLICSKNKTAQKA------------ASKVTLLEANRAKN 646
Query: 696 CNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHE---LD 752
I L + S +EI RAI T D Q LP D +E L++F+P ++++ LL +++ E L+
Sbjct: 647 LAITLRKAGRSAEEICRAIHTFDLQ-TLPVDFVECLMRFLPTEAEVKLLRQYERERQPLE 705
Query: 753 RMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQ 812
+A DRF+ S++ QR+ + F F + + + P++ AI + S V S LKQ
Sbjct: 706 ELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQ 765
Query: 813 LLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVL 872
+LE++LA GNYMN +RG YGFK+ SL+ + DTKS+ D+ +TLLH++ V+ KYP +
Sbjct: 766 MLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKST-DRKMTLLHFIALTVKEKYPDLA 824
Query: 873 NLNEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKSQPPQPGDKFVSVVSQFI 932
N EL + +AA V++ + ++ L G++ + E + SV+ F+
Sbjct: 825 NFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDN----------SVLRNFL 874
Query: 933 TVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGIFDQFLQAVSEAKQENEN 992
+ ++ A++ + V++FGE P FF +F +F+++ EA+QENE
Sbjct: 875 STNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENE- 933
Query: 993 MRKKKEEEERR-------ARMEAQLKEQRER--------ERKMRKAKEN----SEESGEF 1033
RKK+EE R +++A+ QR + E + R+AKE+ + G
Sbjct: 934 ARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTI 993
Query: 1034 DDLVSAL 1040
+D+++ L
Sbjct: 994 EDIITGL 1000
Score = 47.4 bits (111), Expect = 7e-05
Identities = 34/139 (24%), Positives = 64/139 (46%), Gaps = 13/139 (9%)
Query: 45 LPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEENKGATSWPE 104
+PMP EL+ F+ ++ ++L + EKKW + C +++ Q +N P
Sbjct: 26 MPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNP-----PH 80
Query: 105 FYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLD--GLSCIL 162
YI +L S + +E +K + L+ +LRT + +V F++ + GL ++
Sbjct: 81 TYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLV 140
Query: 163 NFLK------TMDYETSES 175
++L D+E ES
Sbjct: 141 DYLSFAQCSVMFDFEGLES 159
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 294 bits (753), Expect = 3e-79
Identities = 193/569 (33%), Positives = 306/569 (53%), Gaps = 46/569 (8%)
Query: 525 ASIPGG----PSPGAPGG----PFPSSVPGSLLPPPPPPPLPGGM-LPPPPPPLP--PGG 573
+S+PGG P P PG P P +PGS PPPPPPLPG +PPPPPPLP PG
Sbjct: 658 SSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGI 717
Query: 574 PPPPP-------GPPPLGAIMPPP-----GAP----MGLALKKKSIPQPTNALKSFNWSK 617
PPPPP PPP G MPPP G P + L K + +P L+ NWSK
Sbjct: 718 PPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSK 777
Query: 618 L-PENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDFFVNSNSKQKEADAIDDTL 676
L E+ + WT++ + + L TFSA + S +K+ + +
Sbjct: 778 LVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTK------TSKAKKDQEGGEEKKS 831
Query: 677 SSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVP 736
K KVKEL V+D + AQN +I L ++ EIK IL ++E L + M++ L+K +P
Sbjct: 832 VQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAV-LTESMIQNLIKQMP 890
Query: 737 EKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEA 796
E + +L E K E D +A++++F M + + RL ++ FK +F+E+V +KP++ +
Sbjct: 891 EPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVS 950
Query: 797 IRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQR-GNAYGFKISSLNKIADTKSSIDKNIT 855
+ + EE+ +S + LLE+ L GNYMN G R A+GF IS L K+ DTKS+ D+ +T
Sbjct: 951 VTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKST-DQKMT 1009
Query: 856 LLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKS 915
LLH+L + EN YP VL +EL + +A++V+ L K + ++ + VE +++ +
Sbjct: 1010 LLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPA 1069
Query: 916 QPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGI 975
+ DKFV ++ F+ A ++ + + + + L+ + ++F + K+ +EFF
Sbjct: 1070 ATDEK-DKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMD 1128
Query: 976 FDQFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQRERERKMRKAKE------NSEE 1029
F +A +EN+ R++ EE+ RRA++ A+ K ++ER K +K ++ +E
Sbjct: 1129 LHNFRNMFLQAVKENQK-RRETEEKMRRAKL-AKEKAEKERLEKQQKREQLIDMNAEGDE 1186
Query: 1030 SGEFDDLVSALRSGEVFDKDLSKLKRNRK 1058
+G D L+ AL+SG F + + NRK
Sbjct: 1187 TGVMDSLLEALQSGAAFRRKRGPRQANRK 1215
Score = 206 bits (524), Expect = 1e-52
Identities = 163/579 (28%), Positives = 284/579 (49%), Gaps = 60/579 (10%)
Query: 51 EELDVMFSELVDELDLTDKH----REAMFALPAEKKWQIYCSKKKDQEENKGATSWPEFY 106
E++ V+F +++ +++L ++ RE + E Q + K + + + S Y
Sbjct: 81 EQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYLYTSKAGMSQKESSKS-AMMY 139
Query: 107 IDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLDGLSCILNFLK 166
I +L S LL+ +ESL+ +L P+ +V F +GL+ +L+ LK
Sbjct: 140 IQELRSGLRDMPLLSC-----------LESLRVSLNNNPVSWVQTF-GAEGLASLLDILK 187
Query: 167 TMDYETSE------SRIHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTK 220
+ E E SR +I C+KA MNN G +L E I ++ +++
Sbjct: 188 RLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMM 247
Query: 221 VAVLEILGAVCLVPGG---HKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSL 277
+ ++L A+C++P +++VL+AM + E RFQ L++ L T ++L
Sbjct: 248 IDAAKLLSALCILPQPEDMNERVLEAMTERAEM-DEVERFQPLLDGLKSGT-----TIAL 301
Query: 278 KTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEM 337
K + INA+++ E LDFR+H+R E + LG+ V+ LRE EN + L+ F+
Sbjct: 302 KVGCLQLINALITPA---EELDFRVHIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDE 358
Query: 338 LRNEDELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFMSILHHCLQMPYKRSGN 397
ED + R + + ++ ++F++ + S+A PHF+SIL H L +
Sbjct: 359 QGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEAR 418
Query: 398 TVQYWLLLDRIIQQIVIQNDKGQDPDSTPLE-NFNIKNVVRMLVNENEVKQWKEQAEKMR 456
QY+ L++ I QIV+ + G DPD I+ ++ ++++ +V++ + +A ++
Sbjct: 419 P-QYYKLIEECISQIVLHKN-GADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELE 476
Query: 457 KE-------HNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQVA 509
K+ +ELQ +++K E + + K Q+ + L+ K+++ TE + ++ +V+
Sbjct: 477 KKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQI---ATEKQDLEAEVS 533
Query: 510 DLTAQLHELSRRAVCASIPGGPSPGAPGGPFPSSVPGSLLPPPPPPPLPGG---MLPPPP 566
LT ++ +L++ A S A P SVP S P PP PPLPG ++PPPP
Sbjct: 534 QLTGEVAKLTKELEDAK-KEMASLSAAAITVPPSVP-SRAPVPPAPPLPGDSGTIIPPPP 591
Query: 567 PP----LPPGGPPPPPGPPPLG---AIMPPPGAPMGLAL 598
P PP PPPPP PPPL I PP P G A+
Sbjct: 592 APGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAI 630
Score = 34.3 bits (77), Expect = 0.65
Identities = 16/39 (41%), Positives = 24/39 (61%)
Query: 476 KTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQVADLTAQ 514
K +E EE M+ KEK EKE E +Q ++Q+ D+ A+
Sbjct: 1145 KRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAE 1183
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 294 bits (753), Expect = 3e-79
Identities = 193/569 (33%), Positives = 306/569 (53%), Gaps = 46/569 (8%)
Query: 525 ASIPGG----PSPGAPGG----PFPSSVPGSLLPPPPPPPLPGGM-LPPPPPPLP--PGG 573
+S+PGG P P PG P P +PGS PPPPPPLPG +PPPPPPLP PG
Sbjct: 667 SSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGI 726
Query: 574 PPPPP-------GPPPLGAIMPPP-----GAP----MGLALKKKSIPQPTNALKSFNWSK 617
PPPPP PPP G MPPP G P + L K + +P L+ NWSK
Sbjct: 727 PPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSK 786
Query: 618 L-PENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDFFVNSNSKQKEADAIDDTL 676
L E+ + WT++ + + L TFSA + S +K+ + +
Sbjct: 787 LVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTK------TSKAKKDQEGGEEKKS 840
Query: 677 SSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVP 736
K KVKEL V+D + AQN +I L ++ EIK IL ++E L + M++ L+K +P
Sbjct: 841 VQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAV-LTESMIQNLIKQMP 899
Query: 737 EKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEA 796
E + +L E K E D +A++++F M + + RL ++ FK +F+E+V +KP++ +
Sbjct: 900 EPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVS 959
Query: 797 IRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQR-GNAYGFKISSLNKIADTKSSIDKNIT 855
+ + EE+ +S + LLE+ L GNYMN G R A+GF IS L K+ DTKS+ D+ +T
Sbjct: 960 VTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKST-DQKMT 1018
Query: 856 LLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKS 915
LLH+L + EN YP VL +EL + +A++V+ L K + ++ + VE +++ +
Sbjct: 1019 LLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPA 1078
Query: 916 QPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGI 975
+ DKFV ++ F+ A ++ + + + + L+ + ++F + K+ +EFF
Sbjct: 1079 ATDEK-DKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMD 1137
Query: 976 FDQFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQRERERKMRKAKE------NSEE 1029
F +A +EN+ R++ EE+ RRA++ A+ K ++ER K +K ++ +E
Sbjct: 1138 LHNFRNMFLQAVKENQK-RRETEEKMRRAKL-AKEKAEKERLEKQQKREQLIDMNAEGDE 1195
Query: 1030 SGEFDDLVSALRSGEVFDKDLSKLKRNRK 1058
+G D L+ AL+SG F + + NRK
Sbjct: 1196 TGVMDSLLEALQSGAAFRRKRGPRQANRK 1224
Score = 206 bits (524), Expect = 1e-52
Identities = 163/579 (28%), Positives = 284/579 (49%), Gaps = 60/579 (10%)
Query: 51 EELDVMFSELVDELDLTDKH----REAMFALPAEKKWQIYCSKKKDQEENKGATSWPEFY 106
E++ V+F +++ +++L ++ RE + E Q + K + + + S Y
Sbjct: 90 EQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYLYTSKAGMSQKESSKS-AMMY 148
Query: 107 IDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLDGLSCILNFLK 166
I +L S LL+ +ESL+ +L P+ +V F +GL+ +L+ LK
Sbjct: 149 IQELRSGLRDMPLLSC-----------LESLRVSLNNNPVSWVQTF-GAEGLASLLDILK 196
Query: 167 TMDYETSE------SRIHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTK 220
+ E E SR +I C+KA MNN G +L E I ++ +++
Sbjct: 197 RLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMM 256
Query: 221 VAVLEILGAVCLVPGG---HKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSL 277
+ ++L A+C++P +++VL+AM + E RFQ L++ L T ++L
Sbjct: 257 IDAAKLLSALCILPQPEDMNERVLEAMTERAEM-DEVERFQPLLDGLKSGT-----TIAL 310
Query: 278 KTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEM 337
K + INA+++ E LDFR+H+R E + LG+ V+ LRE EN + L+ F+
Sbjct: 311 KVGCLQLINALITPA---EELDFRVHIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDE 367
Query: 338 LRNEDELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFMSILHHCLQMPYKRSGN 397
ED + R + + ++ ++F++ + S+A PHF+SIL H L +
Sbjct: 368 QGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEAR 427
Query: 398 TVQYWLLLDRIIQQIVIQNDKGQDPDSTPLE-NFNIKNVVRMLVNENEVKQWKEQAEKMR 456
QY+ L++ I QIV+ + G DPD I+ ++ ++++ +V++ + +A ++
Sbjct: 428 P-QYYKLIEECISQIVLHKN-GADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELE 485
Query: 457 KE-------HNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQVA 509
K+ +ELQ +++K E + + K Q+ + L+ K+++ TE + ++ +V+
Sbjct: 486 KKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQI---ATEKQDLEAEVS 542
Query: 510 DLTAQLHELSRRAVCASIPGGPSPGAPGGPFPSSVPGSLLPPPPPPPLPGG---MLPPPP 566
LT ++ +L++ A S A P SVP S P PP PPLPG ++PPPP
Sbjct: 543 QLTGEVAKLTKELEDAK-KEMASLSAAAITVPPSVP-SRAPVPPAPPLPGDSGTIIPPPP 600
Query: 567 PP----LPPGGPPPPPGPPPLG---AIMPPPGAPMGLAL 598
P PP PPPPP PPPL I PP P G A+
Sbjct: 601 APGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAI 639
Score = 34.3 bits (77), Expect = 0.65
Identities = 16/39 (41%), Positives = 24/39 (61%)
Query: 476 KTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQVADLTAQ 514
K +E EE M+ KEK EKE E +Q ++Q+ D+ A+
Sbjct: 1154 KRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAE 1192
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 277 bits (709), Expect = 3e-74
Identities = 283/1137 (24%), Positives = 485/1137 (42%), Gaps = 216/1137 (18%)
Query: 39 QTMEPALPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEENKG 98
Q P PMP EL+ F+ ++ ++L + + EKKW++ C +++ Q +N
Sbjct: 21 QPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYDNEKKWELICDQERFQVKNP- 79
Query: 99 ATSWPEFYIDQLNSMA-----ARK------SLLALEKEEEEERSKTIESLKTALRTKPMR 147
P YI +L S +RK S L K +E ++ + L+T+LRT +
Sbjct: 80 ----PAAYIQKLKSYVDTGGVSRKVAADWMSNLGF-KRRVQESTQVLRELETSLRTNHIG 134
Query: 148 FVTRFIDLD--GLSCILNFLK------TMDYETSESRIHTSLIG--CIKALMNNSQGRAH 197
+V F++ + GL +L +L T D E++++ S +++ + S+G
Sbjct: 135 WVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNSEKNKPLEQSVEDLSKGPPS 194
Query: 198 VLAHSESINV-IAQSLSTENIKTKVAVLEILGA-VCLVPGGHKKVLQAMLHYQKYASERT 255
+ S + + + + S + ++ V + VC++ L+A+++YQ S
Sbjct: 195 SVPKSRHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIM------CLRAIMNYQSGFSLVM 248
Query: 256 RFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQP 315
+N++ S K ++ + AV G + I
Sbjct: 249 NHPACVNEIALSLNNKNPRT--KALVLELLAAVCLVRGGHDI---------------ILA 291
Query: 316 VIDKLRE--HENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRKRLTH 373
D +E E ++ +++F RNED +ID A F + H
Sbjct: 292 AFDNFKEVCGEQHRFEKLMEYF---RNEDS----------NIDFMVACMQFI---NIVVH 335
Query: 374 SEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQI-VIQNDKGQDPDSTPLENFNI 432
S +F L Q + G LD ++++ + ++DK Q L+N I
Sbjct: 336 SVENMNFRVFL----QYEFTHLG--------LDLYLERLRLTESDKLQVQIQAYLDN--I 381
Query: 433 KNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKE 492
+V +L + E E+++++ L ++L E E AK E E+ + K E
Sbjct: 382 FDVGALLEDTETKNAVLEHMEELQEQVALLTERLRDAENESMAKIAELEKQLSQARKELE 441
Query: 493 KLEKETTEHKQV----------------KQQVADLTAQLHELSRRA-------------- 522
L + +E + + + L ++ EL +
Sbjct: 442 TLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSI 501
Query: 523 ----VCASIPGG---PSPGAPGG-------PFPSSVPGSLLPPPPP-------------- 554
V + P G P+PG P G P PG+ PPPPP
Sbjct: 502 EILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSA 561
Query: 555 ----PPLPGGMLPPPPPPLP------PGGPPPPPG-----PPPLGAIMPPPGAP------ 593
PPLPG PPP PPLP P PPPPPG PPP PPPG P
Sbjct: 562 PPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGR 621
Query: 594 ----MGLALKKKSIPQPTNALKSFNWSKLPENKLEGTVWTEIDDTKVFKILDLEDLERTF 649
+G +K K Q + NW L +++ GTV+TE++D KV + LD+ D E F
Sbjct: 622 RDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELDMSDFEEQF 681
Query: 650 SAYQRQQDFFVNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDE 709
S + A+ + K K ++I+ RA+N I L + L +
Sbjct: 682 KT---------KSQGPSLDLSALKSKAAQKAPSKA-TLIEANRAKNLAITLRKGNLGAER 731
Query: 710 IKRAILTMDEQEDLPKDMLEQLLKFVP---EKSDIDLLEEHKHELDRMAKADRFLFEMSR 766
I +AI D Q L D LE L++F+P E+S I E + ++ +++ DRF+ SR
Sbjct: 732 ICQAIEAYDLQA-LGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSR 790
Query: 767 INHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNK 826
I +R+ +L F F + + P++ AI + S + S L+Q+LE+VLAFGNYMN
Sbjct: 791 IPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNS 850
Query: 827 GQRGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAK 886
+RG AYGF++ SL+ + + KS+ D+ TLLHYL+ ++ KYP + + +L + +A
Sbjct: 851 SKRGAAYGFRLQSLDALLEMKST-DRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGS 909
Query: 887 VNMTELDKEISTLRSGLKAVETELEYQKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLL 946
V++ + ++ +L+ GL+ + E Q V+ +F+ S ++ LL
Sbjct: 910 VSLDSVLADVRSLQRGLELTQREFVRQDD---------CMVLKEFLRANS---PTMDKLL 957
Query: 947 AEAK---DLFTKAVKHFGEEAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERR 1003
A++K + F V++FGE P FF +F +F++A +A+QE E +K+ +E
Sbjct: 958 ADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAG 1017
Query: 1004 A------------------RMEAQLKEQRERERKMRKAKENSEESGEFDDLVSALRS 1042
A R + L + +R ++ S+ G +D+++ +++
Sbjct: 1018 ADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIEDIITVIKT 1074
>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
Length = 1211
Score = 192 bits (489), Expect = 1e-48
Identities = 137/470 (29%), Positives = 226/470 (48%), Gaps = 55/470 (11%)
Query: 544 VPGSLLPPPPPPPLPGGMLPPPPP---------------------PLPPGGPPPPPGPPP 582
+P L PPPPPPLP P P+PP PPPPP PPP
Sbjct: 749 IPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPP--PPPPPLPPP 806
Query: 583 LGAIMPPPGAPMGLALKKKSIPQPTNALKSFNWSKLPENKLEGTVWTEI-DDTKVFKILD 641
+ PP GL ++ + +K W ++ + EGT+W ++ +D+ K+ D
Sbjct: 807 VPCA--PPMLSRGLGHRRSETSHMS--VKRLRWEQVENS--EGTIWGQLGEDSDYDKLSD 860
Query: 642 LE---DLERTFSAYQRQQDFFVNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNI 698
+ DLE F QK A + + K + + ++ ++A N +I
Sbjct: 861 MVKYLDLELHFGT--------------QKPAKPVPGPEPFRKK-EVVEILSHKKAYNTSI 905
Query: 699 LLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKAD 758
LL+ LKLS E+++ +++M+ + P L QLL F P+ + + + R+++ D
Sbjct: 906 LLAHLKLSPAELRQVLMSMEPRRLEPAH-LAQLLLFAPDADEEQRYQAFREAPGRLSEPD 964
Query: 759 RFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVL 818
+F+ +M + Y+ RL+SL+F+ E+ E++ +E +R S E+ S L ++LE VL
Sbjct: 965 QFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVL 1024
Query: 819 AFGNYMNKGQ--RGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNE 876
A GNY+N GQ GFKI+ L ++ TK ++D T LH L + +P +L +
Sbjct: 1025 AMGNYLNDGQPKTNKTTGFKINFLTELNSTK-TVDGKSTFLHILAKSLSQHFPELLGFAQ 1083
Query: 877 ELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKSQPPQPGDKFVSVVSQFITVAS 936
+L +P AAKVN L +++ L + ++ + S P DKF V+S F+ A
Sbjct: 1084 DLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQ---SISPSSEDKFAMVMSSFLETAQ 1140
Query: 937 FSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGIFDQFLQAVSEA 986
+ ++ L EA + KA+ FGE++ + FFGIF +F+ A
Sbjct: 1141 PALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERA 1190
Score = 34.7 bits (78), Expect = 0.50
Identities = 34/117 (29%), Positives = 46/117 (39%), Gaps = 23/117 (19%)
Query: 497 ETTEHKQVKQQVADLTAQLH-----ELSRRAVCASIPGGPSPGAPGGP-------FPSSV 544
ET K + A+L ++L+ ++ + + P GPSP GP +PS
Sbjct: 545 ETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSWPSE- 603
Query: 545 PGSLLPPPPPPPL-PGGMLPPPPPPLPP-------GGPPPPPGPPPLGAIMPPPGAP 593
LLP P PL GG+ P P P P PGP P+ PP P
Sbjct: 604 --RLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDP 658
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 192 bits (487), Expect = 2e-48
Identities = 149/544 (27%), Positives = 257/544 (47%), Gaps = 62/544 (11%)
Query: 527 IPGGPSPGAPGGPFPSSVPGSLLPPPPPPPLP-------GGMLPPPPPPLP-------PG 572
+P G +P P P G LPPPPPPP P G PPPPPPLP PG
Sbjct: 658 LPSGLGSLSPAPPMPPVSAGPPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPNSPAPPNPG 717
Query: 573 GPPPPPGPPPLGAIMPPPGAPMGLALKKKSIP-----QPTNALKSFNWSKLP----ENKL 623
GPPP P PP L A PPPG GL P +P+ +K W+++
Sbjct: 718 GPPPAPPPPGL-APPPPPGLFFGLGSSSSQCPRKPAIEPSCPMKPLYWTRIQISDRSQNA 776
Query: 624 EGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDFFVNSNSKQKEADAIDDTLSSKLKVK 683
T+W +++ I D + E FS ++ Q++ + +T K KVK
Sbjct: 777 TPTLWDSLEEPD---IRDPSEFEYLFS-----------KDTTQQKKKPLSETYEKKNKVK 822
Query: 684 EL-SVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDID 742
++ ++DG+R+Q IL+S L L +I++AI +D+ + + L L + ++ ++
Sbjct: 823 KIIKLLDGKRSQTVGILISSLHLEMKDIQQAIFNVDDSV-VDLETLAALYENRAQEDELV 881
Query: 743 LLEEH-----KHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAI 797
+ ++ + EL + K ++FL E+++I ++ +R Q + F+ F+E + + KVE I
Sbjct: 882 KIRKYYETSKEEELKLLDKPEQFLHELAQIPNFAERAQCIIFRSVFSEGITSLHRKVEII 941
Query: 798 RSGSEEVFRSGALKQLLEVVLAFGNYMNKGQ--RGNAYGFKISSLNKIADTKSSIDKNIT 855
S+++ ++K +L ++LAFGNYMN G RG A G+ + L K+ D KS D I
Sbjct: 942 TRASKDLLHVKSVKDILALILAFGNYMNGGNRTRGQADGYSLEILPKLKDVKSR-DNGIN 1000
Query: 856 LLHYLITIVENKYPSVLNLNEELRDIPQ------AAKVNMTELDKEISTLRSGLKAVETE 909
L+ Y++ Y + + +P+ A++V +L K++ L+ L+A E +
Sbjct: 1001 LVDYVVKYYLRYYDQEAGTEKSVFPLPEPQDFFLASQVKFEDLIKDLRKLKRQLEASEKQ 1060
Query: 910 LEYQ-KSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHFGEE----A 964
+ K P + F + +F A E L A+ F V++FG +
Sbjct: 1061 MVVVCKESPKEYLQPFKDKLEEFFQKAKKEHKMEESHLENAQKSFETTVRYFGMKPKSGE 1120
Query: 965 GKIQPDEFFGIFDQFLQAVSEA-KQENENMRKK--KEEEERRARMEAQLKEQRERERKMR 1021
+I P F ++ +F K+E++N+ K+ K +E +++ ++ K + ++
Sbjct: 1121 KEITPSYVFMVWYEFCSDFKTIWKRESKNISKERLKMAQESVSKLTSEKKVETKKINPTA 1180
Query: 1022 KAKE 1025
KE
Sbjct: 1181 SLKE 1184
>gi|145309324 FH2 domain containing 1 [Homo sapiens]
Length = 1143
Score = 187 bits (474), Expect = 6e-47
Identities = 134/495 (27%), Positives = 235/495 (47%), Gaps = 48/495 (9%)
Query: 541 PSSVPGSLLPPPPPPPLPGGMLPPPPPPLPP---------GGPPPPPGPPPLGAIM---P 588
P + G PP PPPP PPPPPP PP PPPPP PP G P
Sbjct: 22 PGFMIGQTPPPAPPPP------PPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPP 75
Query: 589 PPGAPMGLALKKKSIPQPTNALKSFNWSKLPENKLEG--TVWTEIDDTKVFKILDLEDLE 646
PPG P + S ++SF W +PE ++ G +WT + +D + +E
Sbjct: 76 PPGLPPTTHMNGYSHLGKKKRMRSFFWKTIPEEQVRGKTNIWTLAARQEHHYQIDTKTIE 135
Query: 647 RTFSAYQRQQDFFVNSNSKQKEADAIDDTLSSKLKV--KELSVIDGRRAQNCNILLSRLK 704
F +Q+D +S ++ TL+S + +E++++D +R+ N I L + K
Sbjct: 136 ELFG---QQEDTTKSSLPRRGR------TLNSSFREAREEITILDAKRSMNIGIFLKQFK 186
Query: 705 LSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEM 764
S I I + E + L + LKF+PE ++ L+ ++ +++ AD FL+ +
Sbjct: 187 KSPRSIVEDI-HQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGL 245
Query: 765 SRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYM 824
++ +Y R++++ KK+F + + + +R+ +E+ L +L +VL GN M
Sbjct: 246 IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM 305
Query: 825 NK-GQRGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQ 883
N G GNA GFK+SSL K+ADTK++ + LLH++ + K +LN +E+L + +
Sbjct: 306 NAGGYAGNAVGFKLSSLLKLADTKAN-KPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQK 364
Query: 884 AAKVNMTELDKEISTLRSGLKAVETELEYQKSQPPQPGDKFVSVVSQFITVASFSFSDVE 943
A++++ + E+ L K+++ + Q + + F+ A ++E
Sbjct: 365 TARLSLENTEAELHLLFVRTKSLKENI--------QRDGELCQQMEDFLQFAIEKLRELE 416
Query: 944 DLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERR 1003
E +D + F E+ ++ DE F IF F ++A ++N + E +
Sbjct: 417 CWKQELQDEAYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNH------DREAQE 470
Query: 1004 ARMEAQLKEQRERER 1018
R +LKEQ +++R
Sbjct: 471 LRQLQRLKEQEQKQR 485
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 178 bits (452), Expect = 2e-44
Identities = 157/575 (27%), Positives = 260/575 (45%), Gaps = 99/575 (17%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPPPPP---------PPLPGGMLPPPPP----------- 567
P P PGA G P P +PG +PPPPP PPLPG +PPPPP
Sbjct: 1164 PPPPLPGA-GIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPA 1222
Query: 568 -PLPPGGP--PPPP-----GPPPL--------------GAIMPP-PGAPMGLALK----- 599
PLPP G PPPP GPP L G + PP P GL +
Sbjct: 1223 PPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGLGMNQDKGS 1282
Query: 600 KKSIPQPTNALKSFNWSKLP----ENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQ 655
+K +P +K W+++ + +W +I++ + D + E FS
Sbjct: 1283 RKQPIEPCRPMKPLYWTRIQLHSKRDSSTSLIWEKIEEPSI----DCHEFEELFS----- 1333
Query: 656 QDFFVNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAIL 715
+ ++ I DT+S + + ++ +R+Q IL+S L L +I+ A++
Sbjct: 1334 ------KTAVKERKKPISDTISKTKAKQVVKLLSNKRSQAVGILMSSLHLDMKDIQHAVV 1387
Query: 716 TMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEH------KHELDRMAKADRFLFEMSRINH 769
+D + + L+ L + + +++ +E+H K + K ++FL+E+S I +
Sbjct: 1388 NLDNSV-VDLETLQALYENRAQSDELEKIEKHGRSSKDKENAKSLDKPEQFLYELSLIPN 1446
Query: 770 YQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQ- 828
+ +R+ + F+ F+E + ++ K+E ++ E + + Q+L +VLAFGNYMN G
Sbjct: 1447 FSERVFCILFQSTFSESICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNYMNGGNK 1506
Query: 829 -RGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNE------ELRDI 881
RG A GF + L K+ D KSS D + +LL Y+++ + + E +D+
Sbjct: 1507 TRGQADGFGLDILPKLKDVKSS-DNSRSLLSYIVSYYLRNFDEDAGKEQCLFPLPEPQDL 1565
Query: 882 PQAAKVNMTELDKEISTLRSGLKAVETEL--EYQKSQPPQPGDKFVSVVSQFITVASFSF 939
QA+++ + K++ L+ LKA E E YQ S + F + QFI A
Sbjct: 1566 FQASQMKFEDFQKDLRKLKKDLKACEVEAGKVYQVSS-KEHMQPFKENMEQFIIQAKIDQ 1624
Query: 940 SDVEDLLAEAKDLFTKAVKHF------GEEAGKIQPDEFFGIFDQFLQAVSEA-KQENEN 992
E+ L E F + +F GE+ ++ P+ FF I+ +F + K+EN+
Sbjct: 1625 EAEENSLTETHKCFLETTAYFFMKPKLGEK--EVSPNAFFSIWHEFSSDFKDFWKKENKL 1682
Query: 993 M---RKKKEEEERRARMEAQLKEQRERERKMRKAK 1024
+ R K+ EE R + L + + R KAK
Sbjct: 1683 LLQERVKEAEEVCRQKKGKSLYKIKPRHDSGIKAK 1717
Score = 71.6 bits (174), Expect = 4e-12
Identities = 43/92 (46%), Positives = 47/92 (51%), Gaps = 15/92 (16%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPP---------PPPPPLPGGMLPPPPPPLPPGGPPPPP 578
P P PGA G P P +PG+ +PP PPPPPLPG + PPPPPLP G PPPP
Sbjct: 955 PPPPLPGA-GIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-PPPPPLPGAGIPPPP 1012
Query: 579 GPPPLGAIMPPP----GAPMGLALKKKSIPQP 606
P G PPP G P L IP P
Sbjct: 1013 PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1044
Score = 71.2 bits (173), Expect = 5e-12
Identities = 43/93 (46%), Positives = 48/93 (51%), Gaps = 15/93 (16%)
Query: 527 IPGGPSPGAPGGPFPSSVPGSLLPPPPP---------PPLPGGMLPPPPPPLPPGGPPPP 577
+P P PGA G P P +PG+ +PPPPP PPLPG + PPPPPLP G PPP
Sbjct: 932 LPLPPLPGA-GIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGI-PPPPPLPGAGIPPP 989
Query: 578 PGPPPLGAIMPPP----GAPMGLALKKKSIPQP 606
P P G PPP G P L IP P
Sbjct: 990 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1022
Score = 70.9 bits (172), Expect = 6e-12
Identities = 43/92 (46%), Positives = 48/92 (52%), Gaps = 15/92 (16%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPP---------PPPPPLPGGMLPPPPPPLPPGGPPPPP 578
P P PGA G P P +PG+ +PP PPPPPLPG + PPPPPLP G PPPP
Sbjct: 1043 PPPPLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-PPPPPLPGAGIPPPP 1100
Query: 579 GPPPLGAIMPPP----GAPMGLALKKKSIPQP 606
P +G PPP G P L IP P
Sbjct: 1101 PLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPP 1132
Score = 70.9 bits (172), Expect = 6e-12
Identities = 43/92 (46%), Positives = 48/92 (52%), Gaps = 15/92 (16%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPP---------PPPPPLPGGMLPPPPPPLPPGGPPPPP 578
P P PGA G P P +PG+ +PP PPPPPLPG + PPPPPLP G PPPP
Sbjct: 1120 PPPPLPGA-GIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGI-PPPPPLPGAGIPPPP 1177
Query: 579 GPPPLGAIMPPP----GAPMGLALKKKSIPQP 606
P +G PPP G P L IP P
Sbjct: 1178 PLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPP 1209
Score = 70.5 bits (171), Expect = 8e-12
Identities = 46/102 (45%), Positives = 52/102 (50%), Gaps = 24/102 (23%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPP---------PPPPPLPGGMLPPPPPPLPPGGPPPP- 577
P P PGA G P P +PG+ +PP PPPPPLPG +PPPPP G PPPP
Sbjct: 1054 PPPPLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPP 1112
Query: 578 ------PGPPPL-GAIMPPP------GAPMGLALKKKSIPQP 606
P PPPL GA +PPP G P L + IP P
Sbjct: 1113 LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPP 1154
Score = 70.1 bits (170), Expect = 1e-11
Identities = 43/92 (46%), Positives = 47/92 (51%), Gaps = 15/92 (16%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPP---------PPPPPLPGGMLPPPPPPLPPGGPPPPP 578
P P PGA G P P +PG+ +PP PPPPPLPG + PPPPPLP G PPPP
Sbjct: 977 PPPPLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-PPPPPLPGAGIPPPP 1034
Query: 579 GPPPLGAIMPPP----GAPMGLALKKKSIPQP 606
P G PPP G P L IP P
Sbjct: 1035 PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1066
Score = 70.1 bits (170), Expect = 1e-11
Identities = 43/92 (46%), Positives = 47/92 (51%), Gaps = 15/92 (16%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPP---------PPPPPLPGGMLPPPPPPLPPGGPPPPP 578
P P PGA G P P +PG+ +PP PPPPPLPG + PPPPPLP G PPPP
Sbjct: 988 PPPPLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-PPPPPLPGAGIPPPP 1045
Query: 579 GPPPLGAIMPPP----GAPMGLALKKKSIPQP 606
P G PPP G P L IP P
Sbjct: 1046 PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1077
Score = 70.1 bits (170), Expect = 1e-11
Identities = 43/92 (46%), Positives = 47/92 (51%), Gaps = 15/92 (16%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPP---------PPPPPLPGGMLPPPPPPLPPGGPPPPP 578
P P PGA G P P +PG+ +PP PPPPPLPG + PPPPPLP G PPPP
Sbjct: 999 PPPPLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-PPPPPLPGAGIPPPP 1056
Query: 579 GPPPLGAIMPPP----GAPMGLALKKKSIPQP 606
P G PPP G P L IP P
Sbjct: 1057 PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1088
Score = 70.1 bits (170), Expect = 1e-11
Identities = 43/92 (46%), Positives = 47/92 (51%), Gaps = 15/92 (16%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPP---------PPPPPLPGGMLPPPPPPLPPGGPPPPP 578
P P PGA G P P +PG+ +PP PPPPPLPG + PPPPPLP G PPPP
Sbjct: 1010 PPPPLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-PPPPPLPGAGIPPPP 1067
Query: 579 GPPPLGAIMPPP----GAPMGLALKKKSIPQP 606
P G PPP G P L IP P
Sbjct: 1068 PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1099
Score = 70.1 bits (170), Expect = 1e-11
Identities = 43/92 (46%), Positives = 47/92 (51%), Gaps = 15/92 (16%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPPPPP---------PPLPGGMLPPPPPPLPPGGPPPPP 578
P P PGA G P P +PG+ +PPPPP PPLPG + PPPPPLP G PPPP
Sbjct: 1032 PPPPLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-PPPPPLPGAGIPPPP 1089
Query: 579 GPPPLGAIMPPP----GAPMGLALKKKSIPQP 606
P G PPP G P L IP P
Sbjct: 1090 PLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPP 1121
Score = 70.1 bits (170), Expect = 1e-11
Identities = 43/92 (46%), Positives = 47/92 (51%), Gaps = 15/92 (16%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPPPPP---------PPLPGGMLPPPPPPLPPGGPPPPP 578
P P PGA G P P +PG+ +PPPPP PPLPG + PPPPPLP G PPPP
Sbjct: 1076 PPPPLPGA-GIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGI-PPPPPLPGAGIPPPP 1133
Query: 579 GPPPLGAIMPPP----GAPMGLALKKKSIPQP 606
P G PPP G P L IP P
Sbjct: 1134 PLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPP 1165
Score = 69.7 bits (169), Expect = 1e-11
Identities = 43/92 (46%), Positives = 47/92 (51%), Gaps = 15/92 (16%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPP---------PPPPPLPGGMLPPPPPPLPPGGPPPPP 578
P P PGA G P P +PG+ +PP PPPPPLPG + PPPPPLP G PPPP
Sbjct: 1021 PPPPLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-PPPPPLPGAGIPPPP 1078
Query: 579 GPPPLGAIMPPP----GAPMGLALKKKSIPQP 606
P G PPP G P L IP P
Sbjct: 1079 PLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPP 1110
Score = 69.7 bits (169), Expect = 1e-11
Identities = 43/92 (46%), Positives = 47/92 (51%), Gaps = 15/92 (16%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPP---------PPPPPLPGGMLPPPPPPLPPGGPPPPP 578
P P PGA G P P +PG +PP PPPPPLPG + PPPPPLP G PPPP
Sbjct: 1087 PPPPLPGA-GIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGI-PPPPPLPGAGIPPPP 1144
Query: 579 GPPPLGAIMPPP----GAPMGLALKKKSIPQP 606
P +G PPP G P L IP P
Sbjct: 1145 PLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPP 1176
Score = 68.9 bits (167), Expect = 2e-11
Identities = 42/89 (47%), Positives = 46/89 (51%), Gaps = 15/89 (16%)
Query: 531 PSPGAPGGPFPSSVPGSLLPPPPP---------PPLPGGMLPPPPPPLPPGGPPPPPGPP 581
P PGA G P P +PG+ +PPPPP PPLPG + PPPPPLP G PPPP P
Sbjct: 969 PLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-PPPPPLPGAGIPPPPPLP 1026
Query: 582 PLGAIMPPP----GAPMGLALKKKSIPQP 606
G PPP G P L IP P
Sbjct: 1027 GAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1055
Score = 67.8 bits (164), Expect = 5e-11
Identities = 45/105 (42%), Positives = 50/105 (47%), Gaps = 23/105 (21%)
Query: 525 ASIPGGPSPGAPGGPFPSSVPGSLLPP---------PPPPPLPGGMLPPPPPPLPPGGPP 575
A IP P G P P +PG+ +PP PPPPPLPG +PPPPP G PP
Sbjct: 1094 AGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPP 1153
Query: 576 PP-------PGPPPL-GAIMPPP------GAPMGLALKKKSIPQP 606
PP P PPPL GA +PPP G P L IP P
Sbjct: 1154 PPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPP 1198
Score = 66.2 bits (160), Expect = 2e-10
Identities = 46/115 (40%), Positives = 55/115 (47%), Gaps = 37/115 (32%)
Query: 525 ASIPG-----GPSPGAPGGPFPSSVPGSLLP-----------PPPPPPLPGGMLPPPPP- 567
+S+PG P P PG P+ +P + +P PPPPPPLPG +PPPPP
Sbjct: 868 SSMPGLGMVPPPPPPLPGMTVPT-LPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPL 926
Query: 568 ------PLPP----GGPPPPPGPPPLGAIMPPP------GAPMGLALKKKSIPQP 606
PLPP G PPPPP P GA +PPP G P+ L IP P
Sbjct: 927 PGAGILPLPPLPGAGIPPPPPLP---GAAIPPPPPLPGAGIPLPPPLPGAGIPPP 978
Score = 65.1 bits (157), Expect = 3e-10
Identities = 40/98 (40%), Positives = 44/98 (44%), Gaps = 24/98 (24%)
Query: 533 PGAPGGPFPSSVPGSLLPPPPPPPLPG--------------------GMLPPPPPPLPPG 572
P P SS+PG + PPPPPPLPG MLPPPPPPLP
Sbjct: 859 PPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGA 918
Query: 573 GPPPPPGPPPLGAIMPPP----GAPMGLALKKKSIPQP 606
G PPPP P G + PP G P L +IP P
Sbjct: 919 GIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPP 956
Score = 65.1 bits (157), Expect = 3e-10
Identities = 43/97 (44%), Positives = 47/97 (48%), Gaps = 18/97 (18%)
Query: 525 ASIPGGPSPGAPGG--PFPSSVPGSLLP---------PPPPPPLPGGMLPPPPPPLPPGG 573
A IP P P PG P P +PG+ +P PPPPPLPG + PPPPPLP G
Sbjct: 940 AGIP--PPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGI-PPPPPLPGAG 996
Query: 574 PPPPPGPPPLGAIMPPP----GAPMGLALKKKSIPQP 606
PPPP P G PPP G P L IP P
Sbjct: 997 IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1033
Score = 35.0 bits (79), Expect = 0.38
Identities = 55/248 (22%), Positives = 82/248 (33%), Gaps = 102/248 (41%)
Query: 445 VKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKM---KEKLEKETTEH 501
++Q ++ E +R + EL+++ + E + Q E + + +LE++ H
Sbjct: 676 IQQLEQTIEDLRTKIAELERQYPALDTEVASGHQGLENGVTASGDVCLEALRLEEKEVRH 735
Query: 502 KQVKQQVADLTAQLHE--LSRRAVCASIPGGPS--PGAPGGP---FPSSVP--------- 545
++ + + T+ E + +PG P PGA GP F S +
Sbjct: 736 HRILEAKSIQTSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRIS 795
Query: 546 ---------GSLLPPPPPPPL--------PG----------------------------- 559
S+ PPPPP L PG
Sbjct: 796 VQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNI 855
Query: 560 ------------------GMLPPPPPPLP------------PGGPP-------PPPGPPP 582
GM+PPPPPPLP P PP PPP PP
Sbjct: 856 PSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPL 915
Query: 583 LGAIMPPP 590
GA +PPP
Sbjct: 916 PGAGIPPP 923
Score = 35.0 bits (79), Expect = 0.38
Identities = 25/69 (36%), Positives = 31/69 (44%), Gaps = 31/69 (44%)
Query: 549 LPPPPPPP-------LPG-GMLPPPPPPLPPGGPPPPPG-------------PPPLGA-- 585
+P PPP P +PG GM+PPPP PP PG PPPL
Sbjct: 855 IPSPPPLPCTESSSSMPGLGMVPPPP--------PPLPGMTVPTLPSTAIPQPPPLQGTE 906
Query: 586 IMPPPGAPM 594
++PPP P+
Sbjct: 907 MLPPPPPPL 915
Score = 30.8 bits (68), Expect = 7.2
Identities = 23/74 (31%), Positives = 26/74 (35%), Gaps = 10/74 (13%)
Query: 528 PGGPSPGAPGGPFP-------SSVPGSLLPPP---PPPPLPGGMLPPPPPPLPPGGPPPP 577
P G + APG P S +P SL P PP PGG+ P LP P
Sbjct: 256 PSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEAPSLPAAQPAAK 315
Query: 578 PGPPPLGAIMPPPG 591
P P G
Sbjct: 316 DSPSSTAFPFPEAG 329
>gi|58331242 formin homology 2 domain containing 3 [Homo sapiens]
Length = 1439
Score = 140 bits (353), Expect = 6e-33
Identities = 115/372 (30%), Positives = 179/372 (48%), Gaps = 42/372 (11%)
Query: 550 PPPPPPPLPGGMLPPPPPPLPPGGPPPP-PG----PPP--------LGAIMPPPGAPMGL 596
PPPPPPP G+ PPPPPPL PPPP PG PPP LG P G P
Sbjct: 846 PPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQGLGWSQVPRGQPT-F 904
Query: 597 ALKKKSIPQPTNALKSFNWSKLPENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQ 656
KKK+I N ++ F+W + +W++++ KV D LE F + ++
Sbjct: 905 TKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKV----DTSRLEHLFESKSKEL 960
Query: 657 DFFVNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILT 716
S SK+ AD K +E+ V+D +R+ NI L+ L IK AIL
Sbjct: 961 -----SVSKKTAADG---------KRQEIIVLDSKRSNAINIGLTVLPPPR-TIKIAILN 1005
Query: 717 MDEQEDLPKDMLEQLLKFVP---EKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQR 773
DE L K+ +E++L +P EK I + E+ + A++FL +S I+ R
Sbjct: 1006 FDEYA-LNKEGIEKILTMIPTDEEKQKIQEAQLANPEIP-LGSAEQFLLTLSSISELSAR 1063
Query: 774 LQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQRGNAY 833
L FK + EV + ++ G +++ + L +L +LA GN++N NA
Sbjct: 1064 LHLWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLN---GTNAK 1120
Query: 834 GFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELD 893
F++S L K+ + K ++ K +LLH++ T+V +P +L E+ I ++AKV+ +L
Sbjct: 1121 AFELSYLEKVPEVKDTVHKQ-SLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQ 1179
Query: 894 KEISTLRSGLKA 905
+ + KA
Sbjct: 1180 DNLCQMERRCKA 1191
Score = 30.8 bits (68), Expect = 7.2
Identities = 21/91 (23%), Positives = 43/91 (47%), Gaps = 9/91 (9%)
Query: 451 QAEKMRKEHNELQQKLEKKER---------ECDAKTQEKEEMMQTLNKMKEKLEKETTEH 501
+ E+ R+E E Q++E++ER + + + Q +EE + L ++ + ++
Sbjct: 458 ERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQAREERYKYLEQLAAEEHEKELRS 517
Query: 502 KQVKQQVADLTAQLHELSRRAVCASIPGGPS 532
+ V + ADL+ L + A A + PS
Sbjct: 518 RSVSRGRADLSLDLTSPAAPACLAPLSHSPS 548
>gi|118572599 formin homology 2 domain containing 1 [Homo sapiens]
Length = 1164
Score = 117 bits (292), Expect = 8e-26
Identities = 105/374 (28%), Positives = 177/374 (47%), Gaps = 35/374 (9%)
Query: 546 GSLLPPPPPP-PLPGGMLPPPP--PPLPPGGPPPPPGPPPLGAIMPPPGAPMGLAL--KK 600
G +P P PP PL G+ PPPP PP P GP PPP P PL A + P P AL K+
Sbjct: 566 GKDIPAPSPPLPLLSGVPPPPPLPPPPPIKGPFPPPPPLPLAAPL-PHSVPDSSALPTKR 624
Query: 601 KSIPQPTNALKSFNWSKLPENKLE--GTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDF 658
K++ LK + ++ T+W +D V D LE F
Sbjct: 625 KTVKLFWRELKLAGGHGVSASRFGPCATLWASLDPVSV----DTARLEHLF--------- 671
Query: 659 FVNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMD 718
S+ KE + + + + +V+D +R+ NI L+ L + IK A+L D
Sbjct: 672 ----ESRAKE--VLPSKKAGEGRRTMTTVLDPKRSNAINIGLTTLPPVH-VIKAALLNFD 724
Query: 719 EQEDLPKDMLEQLLKFVPEKSDIDLLEEHK--HELDRMAKADRFLFEMSRINHYQQRLQS 776
E + KD +E+LL +P + + +EE + + + A+ FL ++ I RLQ
Sbjct: 725 EFA-VSKDGIEKLLTMMPTEEERQKIEEAQLANPDIPLGPAENFLMTLASIGGLAARLQL 783
Query: 777 LYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQRGNAYGFK 836
FK + E+ + ++ G E++ ++ + +L +LA GN++N Q + GF+
Sbjct: 784 WAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGSQ---SSGFE 840
Query: 837 ISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEI 896
+S L K+++ K ++ + +LLH+L ++V P +L E+ + + AKV+ +L + +
Sbjct: 841 LSYLEKVSEVKDTVRRQ-SLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENL 899
Query: 897 STLRSGLKAVETEL 910
L +A E L
Sbjct: 900 GQLERRSRAAEESL 913
>gi|14249316 hypothetical protein LOC84800 [Homo sapiens]
Length = 234
Score = 90.9 bits (224), Expect = 6e-18
Identities = 55/179 (30%), Positives = 97/179 (54%), Gaps = 13/179 (7%)
Query: 148 FVTRFIDLDGLSCILNFLKTMD----YETSESRIHTSLIGCIKALMNNSQGRAHVLAHSE 203
++ +F++ GL +L L + S++ + + + C++A+MN+ QG ++L++
Sbjct: 64 WMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQG 123
Query: 204 SINVIAQSLSTENIKTKVAVLEILGAVCLV-PGGHKKVLQAMLHYQKYASERTRFQTLIN 262
+ ++Q+L T N+ K V E+L A+C+ P GH L A+ HY+ S++ RF ++N
Sbjct: 124 YVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMN 183
Query: 263 DLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLR 321
+L S D V ++S INAV+ G E L R LR EF+ L + V+ +LR
Sbjct: 184 ELSGS-----DNVPYVVTLLSVINAVI---LGPEDLRARTQLRNEFIGLQLLDVLARLR 234
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 89.7 bits (221), Expect = 1e-17
Identities = 60/177 (33%), Positives = 82/177 (46%), Gaps = 35/177 (19%)
Query: 449 KEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQV 508
+E+ E+ R+E E Q++LE++ER + ++E + + E+LE+E E ++ +Q
Sbjct: 193 RERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLE 252
Query: 509 ADLTAQLH-ELSRRAVCASIPGG--------------PSPGAPGGPFPSSVPGSL----- 548
+ QL E RR A+ P PG P+ P
Sbjct: 253 RE---QLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLG 309
Query: 549 -LPPPPPPPLPGGML-----------PPPPPPLPPGGPPPPPGPPPLGAIMPPPGAP 593
L PPPPPPLP G PPPPPPLP GPPPPP PPPL +PPP P
Sbjct: 310 PLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPP 366
Score = 32.3 bits (72), Expect = 2.5
Identities = 21/92 (22%), Positives = 46/92 (50%), Gaps = 12/92 (13%)
Query: 985 EAKQENENMRKKKEEEERRARMEAQLKEQRERERKMRKAKENSEESGEFDDLVSALRSGE 1044
+ + E + +++E ER+ R++ + +E++ERER R +E E + E
Sbjct: 201 QERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQ-----------E 249
Query: 1045 VFDKDLSKLKRNRKRITNQMTDSSRERPITKL 1076
+++ + +R R RI++ +S E P+ +
Sbjct: 250 QLEREQLEWERER-RISSAAAPASVETPLNSV 280
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 89.7 bits (221), Expect = 1e-17
Identities = 60/177 (33%), Positives = 82/177 (46%), Gaps = 35/177 (19%)
Query: 449 KEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQV 508
+E+ E+ R+E E Q++LE++ER + ++E + + E+LE+E E ++ +Q
Sbjct: 193 RERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLE 252
Query: 509 ADLTAQLH-ELSRRAVCASIPGG--------------PSPGAPGGPFPSSVPGSL----- 548
+ QL E RR A+ P PG P+ P
Sbjct: 253 RE---QLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLG 309
Query: 549 -LPPPPPPPLPGGML-----------PPPPPPLPPGGPPPPPGPPPLGAIMPPPGAP 593
L PPPPPPLP G PPPPPPLP GPPPPP PPPL +PPP P
Sbjct: 310 PLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPP 366
Score = 32.3 bits (72), Expect = 2.5
Identities = 21/92 (22%), Positives = 46/92 (50%), Gaps = 12/92 (13%)
Query: 985 EAKQENENMRKKKEEEERRARMEAQLKEQRERERKMRKAKENSEESGEFDDLVSALRSGE 1044
+ + E + +++E ER+ R++ + +E++ERER R +E E + E
Sbjct: 201 QERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQ-----------E 249
Query: 1045 VFDKDLSKLKRNRKRITNQMTDSSRERPITKL 1076
+++ + +R R RI++ +S E P+ +
Sbjct: 250 QLEREQLEWERER-RISSAAAPASVETPLNSV 280
>gi|162329583 cleavage and polyadenylation specific factor 6, 68 kD
subunit [Homo sapiens]
Length = 551
Score = 71.6 bits (174), Expect = 4e-12
Identities = 39/78 (50%), Positives = 42/78 (53%), Gaps = 13/78 (16%)
Query: 525 ASIPGG------PSPGAPGGPFPSSVPGS-LLPPP-----PPPPLPGGMLPPPPPPLPPG 572
A PGG P G G FP +VPG P P PPPP P G PP PPL P
Sbjct: 186 AGPPGGSSRAAFPQGGRGRGRFPGAVPGGDRFPGPAGPGGPPPPFPAGQ-TPPRPPLGPP 244
Query: 573 GPPPPPGPPPLGAIMPPP 590
GPP PPGPPP G ++PPP
Sbjct: 245 GPPGPPGPPPPGQVLPPP 262
Score = 64.7 bits (156), Expect = 5e-10
Identities = 40/102 (39%), Positives = 45/102 (44%), Gaps = 35/102 (34%)
Query: 526 SIPGG---PSPGAPGGPFPSSVPGSLLPPPPP-----------PPLPGGMLPPP------ 565
++PGG P P PGGP P P PP PP PP PG +LPPP
Sbjct: 210 AVPGGDRFPGPAGPGGP-PPPFPAGQTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPN 268
Query: 566 -----PPPL---------PPGGPPPPPGPPPLGAIMPPPGAP 593
PPP+ PP GP PP PPP+ PPPG P
Sbjct: 269 RGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPVPGYGPPPGPP 310
Score = 63.5 bits (153), Expect = 1e-09
Identities = 39/84 (46%), Positives = 41/84 (48%), Gaps = 22/84 (26%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPPP----------PPPPL----------PGGMLPPPPP 567
P GP PG PG P P PG +LPPP PPPP+ P G LPP PP
Sbjct: 240 PLGP-PGPPGPPGPPP-PGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPP 297
Query: 568 PLPPGGPPPPPGPPPLGAIMPPPG 591
P PG PPP PPP PPPG
Sbjct: 298 PPVPGYGPPPGPPPPQQGPPPPPG 321
Score = 61.6 bits (148), Expect = 4e-09
Identities = 40/92 (43%), Positives = 43/92 (46%), Gaps = 11/92 (11%)
Query: 527 IPGGPSPGAPG-GPFPSSVPGSLLPPPPPPPL---PGGMLPPP----PPPLPPGGPP--P 576
+P GP P PG GP P P PPPPP P P G L PP PPP PG PP P
Sbjct: 292 LPPGPPPPVPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAP 351
Query: 577 PPGPPPLGAIMPPPGAPMGLALKKKSIPQPTN 608
PP P A PPP G+ P PT+
Sbjct: 352 PPAPHVNPAFFPPP-TNSGMPTSDSRGPPPTD 382
Score = 61.2 bits (147), Expect = 5e-09
Identities = 40/91 (43%), Positives = 43/91 (47%), Gaps = 19/91 (20%)
Query: 536 PGGPFPSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGP----------PPLGA 585
PG PF G L P PPPP+P G PPP PP P GPPPPPGP PPL
Sbjct: 280 PGQPFGQPPLGPLPPG-PPPPVP-GYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTL 337
Query: 586 IMPP--PGAPMGLA-----LKKKSIPQPTNA 609
PP PG P G + P PTN+
Sbjct: 338 APPPHLPGPPPGAPPPAPHVNPAFFPPPTNS 368
Score = 41.6 bits (96), Expect = 0.004
Identities = 36/100 (36%), Positives = 37/100 (37%), Gaps = 47/100 (47%)
Query: 527 IPG-GPSPGAPG---------GPFPSSVPGSLLPP---PPPPPLPG---GMLPP------ 564
+PG GP PG P GPFP PG L PP PPP LPG G PP
Sbjct: 300 VPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNP 359
Query: 565 ------------------PPPPLPPGGPPP-------PPG 579
PPP P G PPP PPG
Sbjct: 360 AFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDYGPPG 399
Score = 37.7 bits (86), Expect = 0.059
Identities = 28/79 (35%), Positives = 30/79 (37%), Gaps = 24/79 (30%)
Query: 531 PSPGAPGGPFPSSVPGSLLPPPPPPPLPGGMLPPP------------PPPLPPGGPPPPP 578
P P PG P PG+ PPP P + PPP PPP P G PPP
Sbjct: 339 PPPHLPGPP-----PGA---PPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPY 390
Query: 579 GPPPLGAIMPPPGAPMGLA 597
G PPG M A
Sbjct: 391 DRGDYG----PPGREMDTA 405
>gi|7706501 WW domain binding protein 11 [Homo sapiens]
Length = 641
Score = 71.2 bits (173), Expect = 5e-12
Identities = 41/86 (47%), Positives = 48/86 (55%), Gaps = 12/86 (13%)
Query: 527 IPGGPSPGAPGGPFPSSVPG------SLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGP 580
+P GP PGAP P +PG LLPP PPP P G P PPP LPPG PPP GP
Sbjct: 430 LPPGPPPGAPPFLRPPGMPGLRGPLPRLLPPGPPPGRPPGPPPGPPPGLPPG--PPPRGP 487
Query: 581 PPLGAIMPPPGAPMGLALKKKSIPQP 606
PP +PPP AP G+ + + +P
Sbjct: 488 PPR---LPPP-APPGIPPPRPGMMRP 509
Score = 64.3 bits (155), Expect = 6e-10
Identities = 40/73 (54%), Positives = 42/73 (57%), Gaps = 11/73 (15%)
Query: 527 IPGGPSPGAPGGPFPSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPG--PPPLG 584
+P GP PG P GP P PG LPP PPP P P PPP PPG PPP PG PPL
Sbjct: 458 LPPGPPPGRPPGPPPGPPPG--LPPGPPPRGPP---PRLPPPAPPGIPPPRPGMMRPPL- 511
Query: 585 AIMPPPG-APMGL 596
+PP G AP GL
Sbjct: 512 --VPPLGPAPPGL 522
Score = 57.0 bits (136), Expect = 9e-08
Identities = 36/73 (49%), Positives = 37/73 (50%), Gaps = 11/73 (15%)
Query: 528 PGGPSP----GAPGGPFPSSVPGSLLPPPP---PPPLPGGMLPPPPPPL---PPGGPPPP 577
P GP P G P GP P P L PP P PPP PG M PP PPL PPG PP
Sbjct: 467 PPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLFPPA 526
Query: 578 PGPPPLGAIMPPP 590
P P P G + PP
Sbjct: 527 PLPNP-GVLSAPP 538
Score = 42.7 bits (99), Expect = 0.002
Identities = 50/178 (28%), Positives = 73/178 (41%), Gaps = 30/178 (16%)
Query: 446 KQWKEQAEKMRK-EHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEK--------LEK 496
KQ EK+ + E N +QQ + E+ K ++ E + + ++ EK L K
Sbjct: 51 KQIIRDMEKLDEMEFNPVQQP-QLNEKVLKDKRKKLRETFERILRLYEKENPDIYKELRK 109
Query: 497 ETTEHKQVKQQVADLTAQLHELSRRAVCASIPGGPSPGAPGG------PFPSSVPGSLLP 550
E++Q + Q++ + V SIP P AP P P + P S+L
Sbjct: 110 LEVEYEQKRAQLSQYFDAVKNAQHVEV-ESIPLPDMPHAPSNILIQDIPLPGAQPPSILK 168
Query: 551 PPP---PP-------PLPGGMLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPMGLAL 598
PP PL G +P PP P GPPP P PP ++ G +G AL
Sbjct: 169 KTSAYGPPTRAVSILPLLGHGVPRLPPGRKPPGPPPGPPPP---QVVQMYGRKVGFAL 223
>gi|150417989 cyclin K isoform 1 [Homo sapiens]
Length = 580
Score = 66.2 bits (160), Expect = 2e-10
Identities = 37/76 (48%), Positives = 39/76 (51%), Gaps = 7/76 (9%)
Query: 531 PSPGAPGGPFPSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGPPPLGAIMPPP 590
P+P P P P P S PP PPP PG PPPPP P PPPPP PP A+ PP
Sbjct: 480 PNPPPPPVPPP---PASFPPPAIPPPTPG--YPPPPPTYNPNFPPPPPRLPPTHAV--PP 532
Query: 591 GAPMGLALKKKSIPQP 606
P GL L S P P
Sbjct: 533 HPPPGLGLPPASYPPP 548
Score = 62.0 bits (149), Expect = 3e-09
Identities = 35/76 (46%), Positives = 37/76 (48%), Gaps = 10/76 (13%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPPP-----PPPPLPGGMLPPPPPPLPPGGPPPPPGPPP 582
P P P P P P+S P +PPP PPPP PPPPP LPP PP PP
Sbjct: 480 PNPPPPPVP--PPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPG 537
Query: 583 LG---AIMPPPGAPMG 595
LG A PPP P G
Sbjct: 538 LGLPPASYPPPAVPPG 553
Score = 56.2 bits (134), Expect = 2e-07
Identities = 34/74 (45%), Positives = 38/74 (51%), Gaps = 18/74 (24%)
Query: 531 PSPGAPGGPFPSSVPGSLLPPP--------PPPPLPGGMLPP---PPPPLPPGGPPPPPG 579
P+PG P P P+ P PPP PP P PG LPP PPP +PPGG PP P
Sbjct: 502 PTPGYPPPP-PTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPP 560
Query: 580 PPPLGAIMPPPGAP 593
P +PPPG P
Sbjct: 561 P------IPPPGMP 568
Score = 46.2 bits (108), Expect = 2e-04
Identities = 22/41 (53%), Positives = 24/41 (58%), Gaps = 2/41 (4%)
Query: 541 PSSVPGSLLPPP--PPPPLPGGMLPPPPPPLPPGGPPPPPG 579
P PG LPP PPP +P G PP PPP+PP G PP G
Sbjct: 532 PHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGG 572
Score = 43.5 bits (101), Expect = 0.001
Identities = 24/59 (40%), Positives = 28/59 (47%), Gaps = 4/59 (6%)
Query: 552 PPPPPLPGGMLPPPPPPLPPGGPPPPPGPPPLGAI--MPPPGAPMGLALKKKSIPQPTN 608
PPPP +P + PPLPP PPP PP A+ PPG L K IP P +
Sbjct: 350 PPPPKIP--KIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAH 406
Score = 41.2 bits (95), Expect = 0.005
Identities = 29/79 (36%), Positives = 34/79 (43%), Gaps = 17/79 (21%)
Query: 522 AVCASIPGGPSPGAPGGPF----PSSVPGSLLPPPPPPP---LPGGMLPPP-------PP 567
A+ PG P P P P +P + PP PPP LP PPP PP
Sbjct: 498 AIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPP 557
Query: 568 PLPPGGPPPPPGPPPLGAI 586
P P PPPG PP+G +
Sbjct: 558 VPP---PIPPPGMPPVGGL 573
Score = 39.3 bits (90), Expect = 0.020
Identities = 24/60 (40%), Positives = 25/60 (41%), Gaps = 2/60 (3%)
Query: 549 LPPP--PPPPLPGGMLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPMGLALKKKSIPQP 606
LPP PP LP PP P PP PPPP PP P PG P + P P
Sbjct: 461 LPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPP 520
Score = 37.0 bits (84), Expect = 0.10
Identities = 26/70 (37%), Positives = 28/70 (40%), Gaps = 12/70 (17%)
Query: 533 PGAPGGPFPSSVP------GSLLPPPP--PPPLPGGMLPPPPPPLPPGGPPPPPGPPPLG 584
P P P P P G PP P LP +PPP P P PPP P PP
Sbjct: 364 PLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPP-- 421
Query: 585 AIMPPPGAPM 594
PPP + M
Sbjct: 422 --PPPPSSYM 429
>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
potassium channel 2 [Homo sapiens]
Length = 889
Score = 65.1 bits (157), Expect = 3e-10
Identities = 33/68 (48%), Positives = 35/68 (51%), Gaps = 5/68 (7%)
Query: 529 GGPSPGAPGGPFPSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGP-PPPPGPPPLGAIM 587
GG PG G P+ P PPPPPP P PPPPPP PP GP P PP PP +
Sbjct: 6 GGGRPGESPGATPAPGP----PPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEAL 61
Query: 588 PPPGAPMG 595
PP A G
Sbjct: 62 PPEAADEG 69
Score = 55.5 bits (132), Expect = 3e-07
Identities = 31/78 (39%), Positives = 36/78 (46%), Gaps = 8/78 (10%)
Query: 537 GGPFPSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPMGL 596
GG P PG+ P PPPP PPP PP PPPPP PPP PP P
Sbjct: 6 GGGRPGESPGATPAPGPPPP------PPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAE 59
Query: 597 ALKKKSIPQ--PTNALKS 612
AL ++ + P L+S
Sbjct: 60 ALPPEAADEGGPRGRLRS 77
Score = 44.7 bits (104), Expect = 5e-04
Identities = 35/130 (26%), Positives = 53/130 (40%), Gaps = 13/130 (10%)
Query: 493 KLEKETTEHKQVKQQVA---------DLTAQLHELSRRAVCASIPGGPSPGAPGGPFPSS 543
K ++E + ++ Q+V +T+ + L + A + P P GP
Sbjct: 696 KYDREMVQQAELGQRVGLFPPPPPPPQVTSAIATLQQAAAMSFCPQVARPLV--GPLALG 753
Query: 544 VPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPM-GLALKKKS 602
P L+ PPP P P P PPPP P G P P P P AP+ G AL +
Sbjct: 754 SP-RLVRRPPPGPAPAAASPGPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARR 812
Query: 603 IPQPTNALKS 612
+ + + L +
Sbjct: 813 LSRASRPLSA 822
>gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]
Length = 502
Score = 65.1 bits (157), Expect = 3e-10
Identities = 37/72 (51%), Positives = 39/72 (54%), Gaps = 7/72 (9%)
Query: 531 PSPGAPGGPFPSSVPGSLLPPPPPPPLPG--GMLPPPPPPL--PPGGPPPPPGPPPLGAI 586
P P P GP P PG PPPPPPP G G LPPPPP PP PPPPP PPP +
Sbjct: 351 PPPPTPRGPPP---PGRGGPPPPPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSG 407
Query: 587 MPPPGAPMGLAL 598
P P+ AL
Sbjct: 408 NGPAPPPLPPAL 419
Score = 62.8 bits (151), Expect = 2e-09
Identities = 35/74 (47%), Positives = 37/74 (50%), Gaps = 6/74 (8%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPP----PGPPPL 583
P GP P GGP P P + P PPP PG PP PPP PP PPP P PPPL
Sbjct: 356 PRGPPPPGRGGPPPPPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAPPPL 415
Query: 584 GAIMPPPG--APMG 595
+ P G AP G
Sbjct: 416 PPALVPAGGLAPGG 429
Score = 56.2 bits (134), Expect = 2e-07
Identities = 33/71 (46%), Positives = 35/71 (49%), Gaps = 13/71 (18%)
Query: 529 GGPSPGAP-----GGPFPSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGPP-- 581
GGP P P GP P PG+ PP PPPP P PPPPP GP PPP PP
Sbjct: 365 GGPPPPPPPATGRSGPLPPPPPGAGGPPMPPPPPP----PPPPPS-SGNGPAPPPLPPAL 419
Query: 582 -PLGAIMPPPG 591
P G + P G
Sbjct: 420 VPAGGLAPGGG 430
Score = 55.8 bits (133), Expect = 2e-07
Identities = 34/83 (40%), Positives = 37/83 (44%), Gaps = 4/83 (4%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPPPPPPPLPGGMLPPPP----PPLPPGGPPPPPGPPPL 583
P PS G P P V G+ P PP+P G+ PPPP PP P G PPPP PP
Sbjct: 316 PPPPSRGGNQLPRPPIVGGNKGRSGPLPPVPLGIAPPPPTPRGPPPPGRGGPPPPPPPAT 375
Query: 584 GAIMPPPGAPMGLALKKKSIPQP 606
G P P P G P P
Sbjct: 376 GRSGPLPPPPPGAGGPPMPPPPP 398
Score = 55.1 bits (131), Expect = 4e-07
Identities = 32/76 (42%), Positives = 33/76 (43%), Gaps = 15/76 (19%)
Query: 549 LPPPPPPPLPGGMLPPPP------------PPLPPGGPPPPP---GPPPLGAIMPPPGAP 593
LPPPPPP G LP PP PP+P G PPPP GPPP G PPP P
Sbjct: 313 LPPPPPPSRGGNQLPRPPIVGGNKGRSGPLPPVPLGIAPPPPTPRGPPPPGRGGPPPPPP 372
Query: 594 MGLALKKKSIPQPTNA 609
P P A
Sbjct: 373 PATGRSGPLPPPPPGA 388
Score = 55.1 bits (131), Expect = 4e-07
Identities = 35/74 (47%), Positives = 36/74 (48%), Gaps = 22/74 (29%)
Query: 538 GPFPSSVPGSLLPPPP----PPPLPGGMLPPPPP-------PLPP-----GGPPPPPGPP 581
GP P VP + PPPP PPP G PPPPP PLPP GGPP PP PP
Sbjct: 340 GPLPP-VPLGIAPPPPTPRGPPPPGRGGPPPPPPPATGRSGPLPPPPPGAGGPPMPPPPP 398
Query: 582 PLGAIMPPPGAPMG 595
P PPP G
Sbjct: 399 P-----PPPPPSSG 407
Score = 51.6 bits (122), Expect = 4e-06
Identities = 34/81 (41%), Positives = 35/81 (43%), Gaps = 20/81 (24%)
Query: 530 GPSPGAPGGPFPSSVPGSLLP----------PPPPPPLPG--GMLPPPP-----PPLPPG 572
GP P P G P P PPPPPP G G LPPPP PP+PP
Sbjct: 340 GPLPPVPLGIAP---PPPTPRGPPPPGRGGPPPPPPPATGRSGPLPPPPPGAGGPPMPPP 396
Query: 573 GPPPPPGPPPLGAIMPPPGAP 593
PPPPP P PPP P
Sbjct: 397 PPPPPPPPSSGNGPAPPPLPP 417
Score = 32.0 bits (71), Expect = 3.2
Identities = 22/58 (37%), Positives = 24/58 (41%), Gaps = 11/58 (18%)
Query: 549 LPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPMGLALKKKSIPQP 606
LPPPP P PP PL PGG G PP+G P+ L L I P
Sbjct: 159 LPPPPTPANEERRGGLPPLPLHPGGDQ---GGPPVG--------PLSLGLATVDIQNP 205
>gi|153792074 proline rich 12 [Homo sapiens]
Length = 2036
Score = 64.7 bits (156), Expect = 5e-10
Identities = 50/182 (27%), Positives = 71/182 (39%), Gaps = 32/182 (17%)
Query: 473 CDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELSRR----------- 521
C +E + ++TL E +++ +++ ++ + L +
Sbjct: 1363 CKRLDEELKRNLETLPSFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKDTSTPDGP 1422
Query: 522 --AVCASIPGGPS-PGAP-----GGPFPSSVPGSLLPPPPPPPLPGGMLPPPPPP----L 569
A A++PG P PG P G P P + P PPP P P PPPPPP L
Sbjct: 1423 PLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQPAL 1482
Query: 570 P---------PGGPPPPPGPPPLGAIMPPPGAPMGLALKKKSIPQPTNALKSFNWSKLPE 620
P P PPPPP PPP MP P P A + P A S +LP+
Sbjct: 1483 PSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPEDPELPD 1542
Query: 621 NK 622
+
Sbjct: 1543 TR 1544
Score = 47.8 bits (112), Expect = 6e-05
Identities = 33/82 (40%), Positives = 38/82 (46%), Gaps = 14/82 (17%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPPPPPP-----PLPGGMLPPPPPPLPPGGPPP--PPGP 580
P PSP P PSS P LPPPPPP P PPPPP P PP P P
Sbjct: 1480 PALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPP------PPPPPAAAPLAAPPEEPAAP 1533
Query: 581 PPLGAIMPPPGAPMGLALKKKS 602
P +P P+ LA K+++
Sbjct: 1534 SPEDPELPDT-RPLHLAKKQET 1554
Score = 43.1 bits (100), Expect = 0.001
Identities = 28/75 (37%), Positives = 31/75 (41%), Gaps = 14/75 (18%)
Query: 528 PGGP-SPGAPGGPFPSSVPGSLLPPPPPPPLPGGMLPPP------------PPPLPPGGP 574
P GP PG G P + PG L P PP LP + P PPP PP P
Sbjct: 989 PYGPYCPGRASGAGPET-PGLGLDPNKPPELPSTVNAEPLGLIQSGPHQAAPPPPPPPPP 1047
Query: 575 PPPPGPPPLGAIMPP 589
PP P P G + P
Sbjct: 1048 PPAPASEPKGGLTSP 1062
Score = 40.4 bits (93), Expect = 0.009
Identities = 25/70 (35%), Positives = 29/70 (41%), Gaps = 20/70 (28%)
Query: 548 LLPPPPPPPLPGGMLPPPPPPLP---------------PGGPPPPPGPPPLGAIMPPPGA 592
L+ PPPPP L +L P P P G P PPP PPP PPP
Sbjct: 792 LVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGAPQPPPPPPP-----PPPPM 846
Query: 593 PMGLALKKKS 602
P+ L +S
Sbjct: 847 PLQLEAHLRS 856
Score = 39.3 bits (90), Expect = 0.020
Identities = 28/75 (37%), Positives = 32/75 (42%), Gaps = 28/75 (37%)
Query: 541 PSSVPGSLLPPPPPPPLPGGMLPPPPPP-----------LPPGGPPP---------PPGP 580
P++ G+ PPPPPPP PPPP P L P P P PPG
Sbjct: 826 PATRDGAPQPPPPPPP------PPPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPGA 879
Query: 581 PP--LGAIMPPPGAP 593
LGA+ P P AP
Sbjct: 880 MQELLGALEPLPPAP 894
Score = 36.2 bits (82), Expect = 0.17
Identities = 21/59 (35%), Positives = 23/59 (38%), Gaps = 2/59 (3%)
Query: 525 ASIPGGPSPGAPGGPFPSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGPPPL 583
A P P P P P ++P PPPPPP PP P P P P PL
Sbjct: 1490 APTPSSPPPPPLPPPPPPAMPSP--PPPPPPAAAPLAAPPEEPAAPSPEDPELPDTRPL 1546
Score = 33.9 bits (76), Expect = 0.85
Identities = 25/62 (40%), Positives = 27/62 (43%), Gaps = 4/62 (6%)
Query: 536 PGGPFPSSVPG-SLLPPPPPPPLPGGMLPPPPPPLPPG-GPPPPPGPPPLGAIMPPPGAP 593
P P P P SL PP L G + P PP P G GPP G P GA P +P
Sbjct: 861 PAAPSPRLRPEESLDPPGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPAGAYRSP--SP 918
Query: 594 MG 595
G
Sbjct: 919 QG 920
Score = 33.5 bits (75), Expect = 1.1
Identities = 33/110 (30%), Positives = 39/110 (35%), Gaps = 40/110 (36%)
Query: 534 GAPGGPFPSSVPGSLLPPPPPPP--------LPG------------GMLPPPPPPLP--- 570
G G P P + PPP PP PG G+ P PP LP
Sbjct: 963 GKAGPPEDEGDPKAGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNKPPELPSTV 1022
Query: 571 ---PGG------------PPPPPGPPPLGAIMPPPG--APMGLALKKKSI 603
P G PPPPP PPP A P G +P+ + K K +
Sbjct: 1023 NAEPLGLIQSGPHQAAPPPPPPPPPPPAPASEPKGGLTSPIFCSTKPKKL 1072
Score = 32.7 bits (73), Expect = 1.9
Identities = 32/103 (31%), Positives = 34/103 (33%), Gaps = 43/103 (41%)
Query: 527 IPGGPSPGAPG-GPF--PSSVPGSLLPPPPPPPLP------------------------- 558
+ GG G G GP P PG PPPPP LP
Sbjct: 208 LAGGGVLGPAGLGPAQTPPYRPGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYN 267
Query: 559 -GGMLPPPPPP---LP-----------PGGPPPPPGPPPLGAI 586
G P PPPP LP P PPP PPP A+
Sbjct: 268 FSGAAPGPPPPERALPRQDTVIKHYQRPASAQPPPPPPPAHAL 310
Score = 32.7 bits (73), Expect = 1.9
Identities = 21/56 (37%), Positives = 23/56 (41%), Gaps = 5/56 (8%)
Query: 537 GGPFPSSVPGSLLPP--PP---PPPLPGGMLPPPPPPLPPGGPPPPPGPPPLGAIM 587
G P L PP PP PP +P L P PP P PPP G LG +
Sbjct: 1292 GKRHPPLYQAGLTPPLSPPKSVPPSVPARGLQPQPPATPAVPHPPPSGAFGLGGAL 1347
Score = 32.0 bits (71), Expect = 3.2
Identities = 19/50 (38%), Positives = 22/50 (44%), Gaps = 9/50 (18%)
Query: 554 PPPLPGGMLPP--PPPPLPPGGP-----PPPPGPPPLGAIMPPPGAPMGL 596
PP G+ PP PP +PP P P PP P + PPP GL
Sbjct: 1296 PPLYQAGLTPPLSPPKSVPPSVPARGLQPQPPATPAVPH--PPPSGAFGL 1343
Score = 31.6 bits (70), Expect = 4.2
Identities = 26/85 (30%), Positives = 29/85 (34%), Gaps = 11/85 (12%)
Query: 541 PSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPMGLALKK 600
P S GS PPP P PPP P P P MP P AP +K
Sbjct: 1683 PVSAGGSSAPPPKAPA------PPPKPETPEKTTSEKPPEQTPETAMPEPPAP-----EK 1731
Query: 601 KSIPQPTNALKSFNWSKLPENKLEG 625
S+ +P K E L G
Sbjct: 1732 PSLLRPVEKEKEKEKVTRGERPLRG 1756
Score = 31.2 bits (69), Expect = 5.5
Identities = 16/53 (30%), Positives = 19/53 (35%)
Query: 519 SRRAVCASIPGGPSPGAPGGPFPSSVPGSLLPPPPPPPLPGGMLPPPPPPLPP 571
++ V A P P AP P P PP P +P PP P P
Sbjct: 1680 AKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPEKP 1732
>gi|11386183 WAS protein family, member 2 [Homo sapiens]
Length = 498
Score = 64.3 bits (155), Expect = 6e-10
Identities = 40/91 (43%), Positives = 43/91 (47%), Gaps = 11/91 (12%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPP-PPPPPLPGGMLPPPPPPLPPGGP--PPPPGPP--- 581
P P P P G P PG PP PPPPP P +PPPPPP+ G P PPPP PP
Sbjct: 297 PSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFP 356
Query: 582 --PLGAIMPPPGAPMGL---ALKKKSIPQPT 607
P A PPP P L + QPT
Sbjct: 357 PHPDFAAPPPPPPPPAADYPTLPPPPLSQPT 387
Score = 62.8 bits (151), Expect = 2e-09
Identities = 41/99 (41%), Positives = 46/99 (46%), Gaps = 20/99 (20%)
Query: 529 GGPSPGAPGGPFPSSVPG----SLLPPPPPPPL-------------PGGMLPPPPPPLPP 571
G SPG P P P S P + PPPPPPP P G PPPPPP PP
Sbjct: 340 GFGSPGTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPP 399
Query: 572 GGPPPPPGPPPLGAIMPPPGAPMGLALK-KKSIPQPTNA 609
GPPPPP G PP P+ K K S+P ++A
Sbjct: 400 PGPPPPPFTGADGQPAIPP--PLSDTTKPKSSLPAVSDA 436
Score = 61.6 bits (148), Expect = 4e-09
Identities = 41/100 (41%), Positives = 44/100 (44%), Gaps = 22/100 (22%)
Query: 528 PGGPSPGAPGGPFPSSVPGSLLPPPPPPPLPGGMLPPPP----------PPLPPGGPP-- 575
P P G+P GP P P PPPPPPP+ G PPPP PP PP PP
Sbjct: 301 PPAPPLGSPPGPKPGFAPPPA-PPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHP 359
Query: 576 ----PPPGPPPLGA---IMPPP--GAPMGLALKKKSIPQP 606
PPP PPP A +PPP P G A P P
Sbjct: 360 DFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPP 399
Score = 48.5 bits (114), Expect = 3e-05
Identities = 52/189 (27%), Positives = 76/189 (40%), Gaps = 41/189 (21%)
Query: 437 RMLVNENEVKQWKEQAEKMRKEH----NELQQKLEKKERECDAKTQEKEEMMQTLNKMKE 492
+ML + ++ + K + K +K++ N +K++ ++ E EK +M Q + KE
Sbjct: 163 KMLQDTKDIMKEKRKHRKEKKDNPNRGNVNPRKIKTRKEEW-----EKMKMGQEFVESKE 217
Query: 493 KLEKETTEHKQVKQQVADLTAQLHELSRRAVCASIPGGPSPGAPGGPFPSSVPGSLLPPP 552
KL V Q + + + S S P P + P PS +L PPP
Sbjct: 218 KLGTSGYPPTLVYQNGSIGCVENVDAS------SYPPPPQSDSASSPSPSFSEDNLPPPP 271
Query: 553 PPPPLP------GGML------------PPPPPPL--PPG------GPPPPPGPPPLGAI 586
P G+ PPP PPL PPG PP PP PPP
Sbjct: 272 AEFSYPVDNQRGSGLAGPKRSSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIG 331
Query: 587 MPPPGAPMG 595
+PPP P+G
Sbjct: 332 IPPPPPPVG 340
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,270,686
Number of Sequences: 37866
Number of extensions: 2981945
Number of successful extensions: 102025
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1532
Number of HSP's successfully gapped in prelim test: 1656
Number of HSP's that attempted gapping in prelim test: 28035
Number of HSP's gapped (non-prelim): 33644
length of query: 1078
length of database: 18,247,518
effective HSP length: 113
effective length of query: 965
effective length of database: 13,968,660
effective search space: 13479756900
effective search space used: 13479756900
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.