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Search of human proteins with 208431815
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|208431815 protein tyrosine phosphatase, receptor type, K
isoform a [Homo sapiens]
(1446 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 2989 0.0
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 2968 0.0
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 1846 0.0
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 1841 0.0
gi|110735406 protein tyrosine phosphatase, receptor type, U isof... 1783 0.0
gi|110735404 protein tyrosine phosphatase, receptor type, U isof... 1774 0.0
gi|110735402 protein tyrosine phosphatase, receptor type, U isof... 1766 0.0
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 1761 0.0
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 1751 0.0
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 514 e-145
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 514 e-145
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 510 e-144
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 506 e-143
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 503 e-142
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 503 e-142
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 503 e-142
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 503 e-142
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 501 e-141
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 499 e-141
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 499 e-141
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 435 e-121
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 435 e-121
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 435 e-121
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor... 420 e-117
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo... 420 e-117
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 369 e-101
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 354 4e-97
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 330 5e-90
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 330 5e-90
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 330 5e-90
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 2989 bits (7748), Expect = 0.0
Identities = 1446/1446 (100%), Positives = 1446/1446 (100%)
Query: 1 MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHV 60
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHV
Sbjct: 1 MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHV 60
Query: 61 SAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNP 120
SAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNP
Sbjct: 61 SAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNP 120
Query: 121 GTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI 180
GTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
Sbjct: 121 GTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI 180
Query: 181 AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPV 240
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPV
Sbjct: 181 AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPV 240
Query: 241 AQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQL 300
AQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQL
Sbjct: 241 AQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQL 300
Query: 301 LGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE 360
LGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE
Sbjct: 301 LGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE 360
Query: 361 IRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRC 420
IRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRC
Sbjct: 361 IRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRC 420
Query: 421 HTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEE 480
HTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEE
Sbjct: 421 HTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEE 480
Query: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV 540
TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV
Sbjct: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV 540
Query: 541 AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYE 600
AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYE
Sbjct: 541 AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYE 600
Query: 601 GVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQN 660
GVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQN
Sbjct: 601 GVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQN 660
Query: 661 AMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKE 720
AMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKE
Sbjct: 661 AMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKE 720
Query: 721 TKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKL 780
TKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKL
Sbjct: 721 TKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKL 780
Query: 781 AKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAE 840
AKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAE
Sbjct: 781 AKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAE 840
Query: 841 SSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQS 900
SSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQS
Sbjct: 841 SSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQS 900
Query: 901 ASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPS 960
ASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPS
Sbjct: 901 ASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPS 960
Query: 961 HYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTC 1020
HYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTC
Sbjct: 961 HYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTC 1020
Query: 1021 VEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPP 1080
VEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPP
Sbjct: 1021 VEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPP 1080
Query: 1081 SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIF 1140
SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIF
Sbjct: 1081 SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIF 1140
Query: 1141 IHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCS 1200
IHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCS
Sbjct: 1141 IHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCS 1200
Query: 1201 IACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPN 1260
IACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPN
Sbjct: 1201 IACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPN 1260
Query: 1261 TVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINR 1320
TVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINR
Sbjct: 1261 TVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINR 1320
Query: 1321 IFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTI 1380
IFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTI
Sbjct: 1321 IFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTI 1380
Query: 1381 IHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVAL 1440
IHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVAL
Sbjct: 1381 IHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVAL 1440
Query: 1441 EYLESS 1446
EYLESS
Sbjct: 1441 EYLESS 1446
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 2968 bits (7694), Expect = 0.0
Identities = 1440/1446 (99%), Positives = 1440/1446 (99%), Gaps = 6/1446 (0%)
Query: 1 MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHV 60
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHV
Sbjct: 1 MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHV 60
Query: 61 SAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNP 120
SAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNP
Sbjct: 61 SAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNP 120
Query: 121 GTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI 180
GTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
Sbjct: 121 GTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI 180
Query: 181 AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPV 240
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPV
Sbjct: 181 AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPV 240
Query: 241 AQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQL 300
AQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQL
Sbjct: 241 AQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQL 300
Query: 301 LGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE 360
LGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE
Sbjct: 301 LGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE 360
Query: 361 IRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRC 420
IRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRC
Sbjct: 361 IRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRC 420
Query: 421 HTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEE 480
HTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEE
Sbjct: 421 HTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEE 480
Query: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV 540
TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV
Sbjct: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV 540
Query: 541 AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYE 600
AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYE
Sbjct: 541 AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYE 600
Query: 601 GVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQN 660
GVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQN
Sbjct: 601 GVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQN 660
Query: 661 AMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKE 720
AMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKE
Sbjct: 661 AMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKE 720
Query: 721 TKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKL 780
TKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKL
Sbjct: 721 TKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKL 780
Query: 781 AKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAE 840
AKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAE
Sbjct: 781 AKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAE 840
Query: 841 SSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQS 900
SSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQS
Sbjct: 841 SSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQS 900
Query: 901 ASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPS 960
ASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYI DGYQRPS
Sbjct: 901 ASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYI------DGYQRPS 954
Query: 961 HYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTC 1020
HYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTC
Sbjct: 955 HYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTC 1014
Query: 1021 VEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPP 1080
VEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPP
Sbjct: 1015 VEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPP 1074
Query: 1081 SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIF 1140
SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIF
Sbjct: 1075 SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIF 1134
Query: 1141 IHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCS 1200
IHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCS
Sbjct: 1135 IHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCS 1194
Query: 1201 IACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPN 1260
IACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPN
Sbjct: 1195 IACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPN 1254
Query: 1261 TVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINR 1320
TVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINR
Sbjct: 1255 TVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINR 1314
Query: 1321 IFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTI 1380
IFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTI
Sbjct: 1315 IFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTI 1374
Query: 1381 IHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVAL 1440
IHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVAL
Sbjct: 1375 IHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVAL 1434
Query: 1441 EYLESS 1446
EYLESS
Sbjct: 1435 EYLESS 1440
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 1846 bits (4782), Expect = 0.0
Identities = 889/1451 (61%), Positives = 1096/1451 (75%), Gaps = 41/1451 (2%)
Query: 23 LLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDS 82
LL +A G+ +GGC FD+ C Y Q DDF W V+ P MP GS+M+V++
Sbjct: 14 LLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNA 73
Query: 83 SDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVT 142
S G++A L LP +KENDTHCIDF Y + S+ PG LN+ V+VN GPL NPIWN++
Sbjct: 74 SGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNIS 133
Query: 143 GFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLG 202
G R W RAELA+STFWPN YQVIFE ++ G GY+AID+++VL +PC ++PHFLR+
Sbjct: 134 GDPTRTWNRAELAISTFWPNFYQVIFEV-ITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQ 192
Query: 203 DVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTK 262
+VEVNAGQ ATFQC A GR ++LWLQ + D P+ + K + RRF ASF + TK
Sbjct: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
Query: 263 TDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGP 322
D YRC+ ++E G G+SN+A+L+V+EPP PIAPPQL VG TYL IQLNANSI GDGP
Sbjct: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
Query: 323 IILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLIT 382
I+ +EVEY SGSW + V++ +YK+ HLDPDTEYEI VLLTRPGEGGTG PGP L T
Sbjct: 313 IVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRT 372
Query: 383 RTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADC 442
RTKCA+PMR P+ L++ E+++R+I + WE GYN+TRCH++N+T+ Y Y G E +
Sbjct: 373 RTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREE 432
Query: 443 LDMDPKA--PQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQG 500
+ D + PQH + +L PYTNVS+K+IL NPEGRKES+E I+QTDED+PG VP +S+QG
Sbjct: 433 VSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQG 492
Query: 501 TSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMH 560
++FE KIFL W+EP G+IT YEI+Y ++ SFDP + ++ VS L N TH +F
Sbjct: 493 STFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFG 552
Query: 561 LHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPA 620
L+PGTTY F IRAST KGFGP TT ISAP++P YE ++ LN+T T+TV+L+PA
Sbjct: 553 LYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYE-LETPLNQTDNTVTVMLKPA 611
Query: 621 QAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLP 680
++GAP+S YQIVVEE P RTK+ ++CY VP+ +QNA + YYFAAE P +L
Sbjct: 612 HSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQ 671
Query: 681 EPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEV 740
PFT+GDN+TY G+WN PL P K Y IYFQA S ETK CV++ATK AAT +P
Sbjct: 672 AAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKP-- 729
Query: 741 IPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVN 800
+P+P KQTD VKIAG+ AGIL+F+++ L V+L++KK KLAKKRK+ M +TRQEMT MVN
Sbjct: 730 VPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVN 789
Query: 801 AMDRSYADQSTLHAEDPLSITFMDQHNFSPRY-------------------------ENH 835
+MD+SYA+Q T E + +FMD HN + R E H
Sbjct: 790 SMDKSYAEQGTNCDE---AFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDETH 846
Query: 836 SATAESSRLLDVPRYLC-EGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYES 894
+ +++S L+ Y E + PYQTGQLHPAIRVADLLQHI MK ++ YGFKEEYES
Sbjct: 847 TMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYES 906
Query: 895 FFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRD 954
FFEGQSA WD AKKD+NR KNRYGNIIAYDHSRV LQ +E D +SDYIN NYID
Sbjct: 907 FFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYID------ 960
Query: 955 GYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYG 1014
GY RP+HYIATQGP+ ET+YDFWRM+W E +A I+MVTNLVEVGRVKC KYWPDDTE+Y
Sbjct: 961 GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK 1020
Query: 1015 DFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRV 1074
D KVT +E E LAEYV+RTF +E+RG +EIRE++QFHFTGWPDHGVPYHATGLL F+R+V
Sbjct: 1021 DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV 1080
Query: 1075 KLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQT 1134
K +PPSAGP+VVHCSAGAGRTGC+IVIDIMLDMAEREGVVDIYNCV+ LRSRR+NMVQT
Sbjct: 1081 KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQT 1140
Query: 1135 EEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRL 1194
EEQY+FIHDAILEACLCG+T++P + ++ Y+DM ++D QTNSS +K+EF+TLN VTP L
Sbjct: 1141 EEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTL 1200
Query: 1195 QAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVT 1254
+ EDCSIA LPRNH+KNR MD+LPPDRCLPFLITIDGESSNYINAALMDSY+QP+AFIVT
Sbjct: 1201 RVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVT 1260
Query: 1255 QYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMD 1314
Q+PLPNTVKDFWRLV DY CTS+VMLN+VD +Q CPQYWPE G+ R+GPIQVE +S ++
Sbjct: 1261 QHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLE 1320
Query: 1315 CDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEE 1374
D+I+RIFRI N RPQ+GY MVQQFQ+LGW +R+ P SKRSFLKLI QV+KWQEE
Sbjct: 1321 EDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNG 1380
Query: 1375 GEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRF 1434
GEGRT++HCLNGGGRSG FCAI IV EM++ Q VDVFHAVKTLRN+KPNMV+ +QY+F
Sbjct: 1381 GEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKF 1440
Query: 1435 CYDVALEYLES 1445
CY+VALEYL S
Sbjct: 1441 CYEVALEYLNS 1451
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 1841 bits (4769), Expect = 0.0
Identities = 889/1464 (60%), Positives = 1096/1464 (74%), Gaps = 54/1464 (3%)
Query: 23 LLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDS 82
LL +A G+ +GGC FD+ C Y Q DDF W V+ P MP GS+M+V++
Sbjct: 14 LLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNA 73
Query: 83 SDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVT 142
S G++A L LP +KENDTHCIDF Y + S+ PG LN+ V+VN GPL NPIWN++
Sbjct: 74 SGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNIS 133
Query: 143 GFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLG 202
G R W RAELA+STFWPN YQVIFE ++ G GY+AID+++VL +PC ++PHFLR+
Sbjct: 134 GDPTRTWNRAELAISTFWPNFYQVIFEV-ITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQ 192
Query: 203 DVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTK 262
+VEVNAGQ ATFQC A GR ++LWLQ + D P+ + K + RRF ASF + TK
Sbjct: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
Query: 263 TDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGP 322
D YRC+ ++E G G+SN+A+L+V+EPP PIAPPQL VG TYL IQLNANSI GDGP
Sbjct: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
Query: 323 IILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLIT 382
I+ +EVEY SGSW + V++ +YK+ HLDPDTEYEI VLLTRPGEGGTG PGP L T
Sbjct: 313 IVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRT 372
Query: 383 RTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADC 442
RTKCA+PMR P+ L++ E+++R+I + WE GYN+TRCH++N+T+ Y Y G E +
Sbjct: 373 RTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREE 432
Query: 443 LDMDPKA--PQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQG 500
+ D + PQH + +L PYTNVS+K+IL NPEGRKES+E I+QTDED+PG VP +S+QG
Sbjct: 433 VSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQG 492
Query: 501 TSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMH 560
++FE KIFL W+EP G+IT YEI+Y ++ SFDP + ++ VS L N TH +F
Sbjct: 493 STFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFG 552
Query: 561 LHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPA 620
L+PGTTY F IRAST KGFGP TT ISAP++P YE ++ LN+T T+TV+L+PA
Sbjct: 553 LYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYE-LETPLNQTDNTVTVMLKPA 611
Query: 621 QAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLP 680
++GAP+S YQIVVEE P RTK+ ++CY VP+ +QNA + YYFAAE P +L
Sbjct: 612 HSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQ 671
Query: 681 EPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEV 740
PFT+GDN+TY G+WN PL P K Y IYFQA S ETK CV++ATK AAT +P
Sbjct: 672 AAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKP-- 729
Query: 741 IPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVN 800
+P+P KQTD VKIAG+ AGIL+F+++ L V+L++KK KLAKKRK+ M +TRQEMT MVN
Sbjct: 730 VPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVN 789
Query: 801 AMDRSYADQSTLHAEDPLSITFMDQHNFSPRY---------------------------- 832
+MD+SYA+Q T E + +FMD HN + R
Sbjct: 790 SMDKSYAEQGTNCDE---AFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFV 846
Query: 833 ----------ENHSATAESSRLLDVPRYLC-EGTESPYQTGQLHPAIRVADLLQHINLMK 881
E H+ +++S L+ Y E + PYQTGQLHPAIRVADLLQHI MK
Sbjct: 847 PTAILVPINDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMK 906
Query: 882 TSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDY 941
++ YGFKEEYESFFEGQSA WD AKKD+NR KNRYGNIIAYDHSRV LQ +E D +SDY
Sbjct: 907 CAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDY 966
Query: 942 INANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVK 1001
IN NYID GY RP+HYIATQGP+ ET+YDFWRM+W E +A I+MVTNLVEVGRVK
Sbjct: 967 INGNYID------GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVK 1020
Query: 1002 CYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVP 1061
C KYWPDDTE+Y D KVT +E E LAEYV+RTF +E+RG +EIRE++QFHFTGWPDHGVP
Sbjct: 1021 CCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVP 1080
Query: 1062 YHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCV 1121
YHATGLL F+R+VK +PPSAGP+VVHCSAGAGRTGC+IVIDIMLDMAEREGVVDIYNCV
Sbjct: 1081 YHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCV 1140
Query: 1122 KALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLK 1181
+ LRSRR+NMVQTEEQY+FIHDAILEACLCG+T++P + ++ Y+DM ++D QTNSS +K
Sbjct: 1141 RELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIK 1200
Query: 1182 DEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAAL 1241
+EF+TLN VTP L+ EDCSIA LPRNH+KNR MD+LPPDRCLPFLITIDGESSNYINAAL
Sbjct: 1201 EEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAAL 1260
Query: 1242 MDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRY 1301
MDSY+QP+AFIVTQ+PLPNTVKDFWRLV DY CTS+VMLN+VD +Q CPQYWPE G+ R+
Sbjct: 1261 MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRH 1320
Query: 1302 GPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKL 1361
GPIQVE +S ++ D+I+RIFRI N RPQ+GY MVQQFQ+LGW +R+ P SKRSFLKL
Sbjct: 1321 GPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKL 1380
Query: 1362 ILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNS 1421
I QV+KWQEE GEGRT++HCLNGGGRSG FCAI IV EM++ Q VDVFHAVKTLRN+
Sbjct: 1381 IRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNN 1440
Query: 1422 KPNMVEAPEQYRFCYDVALEYLES 1445
KPNMV+ +QY+FCY+VALEYL S
Sbjct: 1441 KPNMVDLLDQYKFCYEVALEYLNS 1464
>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
precursor [Homo sapiens]
Length = 1442
Score = 1783 bits (4619), Expect = 0.0
Identities = 864/1423 (60%), Positives = 1072/1423 (75%), Gaps = 20/1423 (1%)
Query: 33 AGGCTFDDGPGA---CDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGE 89
A GCTF++ C+Y Q YDDF+W V P ++P GSY++V++S H PG+
Sbjct: 24 AAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQ 83
Query: 90 KARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDW 149
+A + ++ ENDTHC+ FSY LYS+ G +PGTL + VRVN GPL + +WN+TG GR W
Sbjct: 84 RAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQW 143
Query: 150 LRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAG 209
+AELAVSTFWPNEYQV+FEA +S R GY+ +DDI +LSYPC K+PHF RLGDVEVNAG
Sbjct: 144 HQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAG 203
Query: 210 QNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYR 269
QNA+FQC+A GR A + LQR++G +P A ++I+HRRF A+F L V++ +QDLYR
Sbjct: 204 QNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYR 263
Query: 270 CVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVE 329
CV+Q+ RG+GVSNFA+LIV+EPP PIAPPQLL GPTYL+IQLN NSIIGDGPI+ KE+E
Sbjct: 264 CVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIE 323
Query: 330 YRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEP 389
YRM G W E HAV+ TYKLWHLDPDTEYEI VLLTRPG+GGTG PGPPLI+RTKCAEP
Sbjct: 324 YRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEP 383
Query: 390 MRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRG--HNESKADCLDMDP 447
MR PK L AEIQAR++ + WE LGYN+TRCHT+ V++CYHY G HN++ +C+ +
Sbjct: 384 MRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQ 443
Query: 448 KAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKI 507
++ + +L PY NV ++++LTNPEGRKE +E QTDEDVP + +SL T E+ I
Sbjct: 444 GVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMI 503
Query: 508 FLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTY 567
FL W+EP +PNG+ITQYEISY SI S DPAV V GP +T+S L N T+HVF +LHPGTTY
Sbjct: 504 FLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTY 563
Query: 568 QFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPI 627
F +RA T KGFG A +TTNISAP+ DY + + L E+ TITVLLRPAQ +GAPI
Sbjct: 564 LFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPI 622
Query: 628 SAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTV 687
S YQ++VEE R +RE G +C+ VP+T++ A++ G +YF AEL +LPE PFTV
Sbjct: 623 SVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAMPFTV 682
Query: 688 GDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQ 747
GDN+TY+GFWNPPL PRK Y IYFQA S ++ ET+ C+RIA KAA E + + +++
Sbjct: 683 GDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPL-EVSQR 741
Query: 748 TDRVVKIAGISAG-ILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSY 806
++ + I GI AG + V ILLL +I+I++K K K A N RQE THM++A+DRS+
Sbjct: 742 SEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTK-ATVNYRQEKTHMMSAVDRSF 800
Query: 807 ADQSTLHAEDPLSITFMDQHNFSPRYENHSA--TAESSRLLDVPRYLCEGTESPYQTGQL 864
DQSTL ++ L ++FMD H +S R + S T SS L PR C SPY TGQL
Sbjct: 801 TDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQL 860
Query: 865 HPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYD 924
HPA+RVADLLQHIN MKT++ YGFK+EYESFFEG WD KK +R + AYD
Sbjct: 861 HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYD 916
Query: 925 HSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQ 984
RV L P+ DP++DYINANYIDI + R+GY R +H+IATQGP E VYDFWRM+WQE
Sbjct: 917 RHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEH 976
Query: 985 SACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEI 1044
+ IVM+T LVEVGRVKC +YWP+D++ YGD K+ V+ E LAEYVVRTF LERRGY+
Sbjct: 977 CSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR 1036
Query: 1045 REVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDI 1104
EV+QFHFT WP+HGVPYHATGLL+FIRRVK S PP AGPIV+HCSAG GRTGCYIV+D+
Sbjct: 1037 HEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDV 1096
Query: 1105 MLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAA 1164
MLDMAE EGVVDIYNCVK L SRR+NM+QTEEQYIFIHDAILEACLCGET IPV EFKA
Sbjct: 1097 MLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKAT 1156
Query: 1165 YFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLP 1224
Y +MIRID Q+NSS L++EFQTLNSVTP L E+CSIA LPRN DKNR MD+LPPDRCLP
Sbjct: 1157 YKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLP 1216
Query: 1225 FLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVD 1284
FLI+ DG+S+NYINAAL DSY + AAFIVT +PL +T DFWRLVYDYGCTSIVMLN+++
Sbjct: 1217 FLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLN 1276
Query: 1285 LSQG---CPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQ 1341
S C QYWPE G +YG ++VE MS + D D++ R+FR+ N++R QEG+L+V+ FQ
Sbjct: 1277 QSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQ 1336
Query: 1342 YLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVE 1401
+L W+++R+ P SK++FL L+ +V+KWQ E G+GRTI+HCLNGGGRSG FCA V+E
Sbjct: 1337 FLRWSAYRDTPDSKKAFLHLLAEVDKWQ--AESGDGRTIVHCLNGGGRSGTFCACATVLE 1394
Query: 1402 MVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1444
M++ N+VDVF A KTLRN KPNMVE +QY FCYDVALEYLE
Sbjct: 1395 MIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1437
>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
precursor [Homo sapiens]
Length = 1436
Score = 1774 bits (4594), Expect = 0.0
Identities = 862/1423 (60%), Positives = 1068/1423 (75%), Gaps = 26/1423 (1%)
Query: 33 AGGCTFDDGPGA---CDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGE 89
A GCTF++ C+Y Q YDDF+W V P ++P GSY++V++S H PG+
Sbjct: 24 AAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQ 83
Query: 90 KARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDW 149
+A + ++ ENDTHC+ FSY LYS+ G +PGTL + VRVN GPL + +WN+TG GR W
Sbjct: 84 RAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQW 143
Query: 150 LRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAG 209
+AELAVSTFWPNEYQV+FEA +S R GY+ +DDI +LSYPC K+PHF RLGDVEVNAG
Sbjct: 144 HQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAG 203
Query: 210 QNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYR 269
QNA+FQC+A GR A + LQR++G +P A ++I+HRRF A+F L V++ +QDLYR
Sbjct: 204 QNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYR 263
Query: 270 CVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVE 329
CV+Q+ RG+GVSNFA+LIV+EPP PIAPPQLL GPTYL+IQLN NSIIGDGPI+ KE+E
Sbjct: 264 CVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIE 323
Query: 330 YRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEP 389
YRM G W E HAV+ TYKLWHLDPDTEYEI VLLTRPG+GGTG PGPPLI+RTKCAEP
Sbjct: 324 YRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEP 383
Query: 390 MRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRG--HNESKADCLDMDP 447
MR PK L AEIQAR++ + WE LGYN+TRCHT+ V++CYHY G HN++ +C+ +
Sbjct: 384 MRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQ 443
Query: 448 KAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKI 507
++ + +L PY NV ++++LTNPEGRKE +E QTDEDVP + +SL T E+ I
Sbjct: 444 GVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMI 503
Query: 508 FLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTY 567
FL W+EP +PNG+ITQYEISY SI S DPAV V GP +T+S L N T+HVF +LHPGTTY
Sbjct: 504 FLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTY 563
Query: 568 QFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPI 627
F +RA T KGFG A +TTNISAP+ DY + + L E+ TITVLLRPAQ +GAPI
Sbjct: 564 LFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPI 622
Query: 628 SAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTV 687
S YQ++VEE R +RE G +C+ VP+T++ A++ G +YF AEL +LPE PFTV
Sbjct: 623 SVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAMPFTV 682
Query: 688 GDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQ 747
GDN+TY+GFWNPPL PRK Y IYFQA S ++ ET+ C+RIA KAA E + + +++
Sbjct: 683 GDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPL-EVSQR 741
Query: 748 TDRVVKIAGISA-GILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSY 806
++ + I GI A G+ V ILLL +I+I++K K K A N RQE THM++A+DRS+
Sbjct: 742 SEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTK-ATVNYRQEKTHMMSAVDRSF 800
Query: 807 ADQSTLHAEDPLSITFMDQHNFSPRYENHS--ATAESSRLLDVPRYLCEGTESPYQTGQL 864
DQSTL ++ L ++FMD H +S R + S T SS L PR C SPY TGQL
Sbjct: 801 TDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQL 860
Query: 865 HPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYD 924
HPA+RVADLLQHIN MKT++ YGFK+EYESFFEG WD KK +R + AYD
Sbjct: 861 HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYD 916
Query: 925 HSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQ 984
RV L P+ DP++DYINANYI DGY R +H+IATQGP E VYDFWRM+WQE
Sbjct: 917 RHRVKLHPMLGDPNADYINANYI------DGYHRSNHFIATQGPKPEMVYDFWRMVWQEH 970
Query: 985 SACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEI 1044
+ IVM+T LVEVGRVKC +YWP+D++ YGD K+ V+ E LAEYVVRTF LERRGY+
Sbjct: 971 CSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR 1030
Query: 1045 REVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDI 1104
EV+QFHFT WP+HGVPYHATGLL+FIRRVK S PP AGPIV+HCSAG GRTGCYIV+D+
Sbjct: 1031 HEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDV 1090
Query: 1105 MLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAA 1164
MLDMAE EGVVDIYNCVK L SRR+NM+QTEEQYIFIHDAILEACLCGET IPV EFKA
Sbjct: 1091 MLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKAT 1150
Query: 1165 YFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLP 1224
Y +MIRID Q+NSS L++EFQTLNSVTP L E+CSIA LPRN DKNR MD+LPPDRCLP
Sbjct: 1151 YKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLP 1210
Query: 1225 FLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVD 1284
FLI+ DG+S+NYINAAL DSY + AAFIVT +PL +T DFWRLVYDYGCTSIVMLN+++
Sbjct: 1211 FLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLN 1270
Query: 1285 LSQG---CPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQ 1341
S C QYWPE G +YG ++VE MS + D D++ R+FR+ N++R QEG+L+V+ FQ
Sbjct: 1271 QSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQ 1330
Query: 1342 YLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVE 1401
+L W+++R+ P SK++FL L+ +V+KWQ E G+GRTI+HCLNGGGRSG FCA V+E
Sbjct: 1331 FLRWSAYRDTPDSKKAFLHLLAEVDKWQ--AESGDGRTIVHCLNGGGRSGTFCACATVLE 1388
Query: 1402 MVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1444
M++ N+VDVF A KTLRN KPNMVE +QY FCYDVALEYLE
Sbjct: 1389 MIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1431
>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
precursor [Homo sapiens]
Length = 1446
Score = 1766 bits (4575), Expect = 0.0
Identities = 860/1432 (60%), Positives = 1067/1432 (74%), Gaps = 34/1432 (2%)
Query: 33 AGGCTFDDGPGA---CDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGE 89
A GCTF++ C+Y Q YDDF+W V P ++P GSY++V++S H PG+
Sbjct: 24 AAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQ 83
Query: 90 KARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDW 149
+A + ++ ENDTHC+ FSY LYS+ G +PGTL + VRVN GPL + +WN+TG GR W
Sbjct: 84 RAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQW 143
Query: 150 LRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAG 209
+AELAVSTFWPNEYQV+FEA +S R GY+ +DDI +LSYPC K+PHF RLGDVEVNAG
Sbjct: 144 HQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAG 203
Query: 210 QNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYR 269
QNA+FQC+A GR A + LQR++G +P A ++I+HRRF A+F L V++ +QDLYR
Sbjct: 204 QNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYR 263
Query: 270 CVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVE 329
CV+Q+ RG+GVSNFA+LIV+EPP PIAPPQLL GPTYL+IQLN NSIIGDGPI+ KE+E
Sbjct: 264 CVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIE 323
Query: 330 YRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEP 389
YRM G W E HAV+ TYKLWHLDPDTEYEI VLLTRPG+GGTG PGPPLI+RTKCAEP
Sbjct: 324 YRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEP 383
Query: 390 MRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRG--HNESKADCLDMDP 447
MR PK L AEIQAR++ + WE LGYN+TRCHT+ V++CYHY G HN++ +C+ +
Sbjct: 384 MRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQ 443
Query: 448 KAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKI 507
++ + +L PY NV ++++LTNPEGRKE +E QTDEDVP + +SL T E+ I
Sbjct: 444 GVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMI 503
Query: 508 FLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTY 567
FL W+EP +PNG+ITQYEISY SI S DPAV V GP +T+S L N T+HVF +LHPGTTY
Sbjct: 504 FLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTY 563
Query: 568 QFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPI 627
F +RA T KGFG A +TTNISAP+ DY + + L E+ TITVLLRPAQ +GAPI
Sbjct: 564 LFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPI 622
Query: 628 SAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTV 687
S YQ++VEE R +RE G +C+ VP+T++ A++ G +YF AEL +LPE PFTV
Sbjct: 623 SVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAMPFTV 682
Query: 688 GDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQ 747
GDN+TY+GFWNPPL PRK Y IYFQA S ++ ET+ C+RIA KAA E + + +++
Sbjct: 683 GDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPL-EVSQR 741
Query: 748 TDRVVKIAGISA-GILVFILLLLVVILIVKKSK---------LAKKRKDAMGNTRQEMTH 797
++ + I GI A G+ V ILLL +I+I++K + A N RQE TH
Sbjct: 742 SEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYSYYPKPVNMTKATVNYRQEKTH 801
Query: 798 MVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHS--ATAESSRLLDVPRYLCEGT 855
M++A+DRS+ DQSTL ++ L ++FMD H +S R + S T SS L PR C
Sbjct: 802 MMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRK 861
Query: 856 ESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKN 915
SPY TGQLHPA+RVADLLQHIN MKT++ YGFK+EYESFFEG WD KK +
Sbjct: 862 GSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGS 917
Query: 916 RYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYD 975
R + AYD RV L P+ DP++DYINANYI DGY R +H+IATQGP E VYD
Sbjct: 918 RQEPMPAYDRHRVKLHPMLGDPNADYINANYI------DGYHRSNHFIATQGPKPEMVYD 971
Query: 976 FWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFT 1035
FWRM+WQE + IVM+T LVEVGRVKC +YWP+D++ YGD K+ V+ E LAEYVVRTF
Sbjct: 972 FWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFA 1031
Query: 1036 LERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGR 1095
LERRGY+ EV+QFHFT WP+HGVPYHATGLL+FIRRVK S PP AGPIV+HCSAG GR
Sbjct: 1032 LERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGR 1091
Query: 1096 TGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETA 1155
TGCYIV+D+MLDMAE EGVVDIYNCVK L SRR+NM+QTEEQYIFIHDAILEACLCGET
Sbjct: 1092 TGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETT 1151
Query: 1156 IPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMD 1215
IPV EFKA Y +MIRID Q+NSS L++EFQTLNSVTP L E+CSIA LPRN DKNR MD
Sbjct: 1152 IPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMD 1211
Query: 1216 MLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCT 1275
+LPPDRCLPFLI+ DG+S+NYINAAL DSY + AAFIVT +PL +T DFWRLVYDYGCT
Sbjct: 1212 VLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCT 1271
Query: 1276 SIVMLNEVDLSQG---CPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQE 1332
SIVMLN+++ S C QYWPE G +YG ++VE MS + D D++ R+FR+ N++R QE
Sbjct: 1272 SIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQE 1331
Query: 1333 GYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGM 1392
G+L+V+ FQ+L W+++R+ P SK++FL L+ +V+KWQ E G+GRTI+HCLNGGGRSG
Sbjct: 1332 GHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQ--AESGDGRTIVHCLNGGGRSGT 1389
Query: 1393 FCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1444
FCA V+EM++ N+VDVF A KTLRN KPNMVE +QY FCYDVALEYLE
Sbjct: 1390 FCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1441
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 1761 bits (4560), Expect = 0.0
Identities = 846/1456 (58%), Positives = 1087/1456 (74%), Gaps = 27/1456 (1%)
Query: 1 MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDL-YDDFEWVH 59
M + AA AL +LLL P L A+ Q +AGGC+FD+ C Y L + F W
Sbjct: 1 MASLAALAL----SLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQ 56
Query: 60 VSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLN 119
++ E L +P GS+M+V+SS G+KA L LPT+KENDTHCIDF Y S+ +
Sbjct: 57 INTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSS 116
Query: 120 PGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGY 179
PG LN+ V+VN GP NP+WNV+G W++AELA+STFWP+ YQVIFE+ G GY
Sbjct: 117 PGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGY 176
Query: 180 IAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIP 239
IA+D+++VL++PC K+PHFLRL +VEVN GQNATFQCIA G+ + H+KLWLQ+ NG D
Sbjct: 177 IAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTA 236
Query: 240 VAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQ 299
+ T+ +NHRRF+A+ + + + YRCV +S+ GSGVSN+A+LIV+EPP PIAPP+
Sbjct: 237 LMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE 296
Query: 300 LLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEY 359
LL VG TYL I+ NANSIIGDGPIILKEVEYR T+G+W ETH V++P YKLWHLDPD EY
Sbjct: 297 LLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEY 356
Query: 360 EIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITR 419
EIRVLLTRPGEGGTG PGPPL TRTKCA+P+ P+ ++I +I+AR++ + WE GY +TR
Sbjct: 357 EIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTR 416
Query: 420 CHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESE 479
CH++N+T+ Y Y N+ + + ++ + + + L P+ + L+++L+NPEGR ESE
Sbjct: 417 CHSYNLTVQYQYV--FNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE 474
Query: 480 ETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVP 539
E ++QT+EDVPG VP++S+QG FE KI++ WK P + NG+IT YEI+Y ++ S DP+
Sbjct: 475 ELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSAD 534
Query: 540 VAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDY 599
++ V L N THH+F+ L+PGTTY F I+AST KGFGP + T ISAP++P+Y
Sbjct: 535 LSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEY 594
Query: 600 EGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQ 659
+ D LNET TTITV+L+PAQ++GAP+S YQ+VV+E +++R A +EC+ VPV+Y+
Sbjct: 595 D-TDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
Query: 660 NAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEK 719
NA S + +YFAAEL P NLP PFTVGDN+TY G+WNPPL+P K Y+IYFQA+S
Sbjct: 654 NASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANG 713
Query: 720 ETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKS- 778
ETK CVR+ATK A+T+ + +P KQ D VK+AG+ AG+L+FI++LL V+L +K+
Sbjct: 714 ETKINCVRLATKGASTQNSNTV-EPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRR 772
Query: 779 ---------KLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFS 829
KLAKK+K+ ++EM + +A D+ S ++ S + D + F+
Sbjct: 773 NAYSYSYYLKLAKKQKETQSGAQREMGPVASA-DKPTTKLSASRNDEGFSSSSQDVNGFT 831
Query: 830 PRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFK 889
+ + + P C+ E Y Q PAIRVADLLQHI MK YGFK
Sbjct: 832 DGSRGE-LSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFK 890
Query: 890 EEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDI 949
EEYE+ EGQ+ASWD AK+D+NR KNRYGNII+YDHSRV L ++ DP SDYINANYID
Sbjct: 891 EEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYID- 949
Query: 950 WLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDD 1009
GY RP HYIATQGP+ ETV DFWRMIWQE SA IVMVTNLVEVGRVKC +YWPDD
Sbjct: 950 -----GYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD 1004
Query: 1010 TEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLS 1069
TEVYGD KVT +E EPLAEYV+RTFT++++GY+EIRE++ FHFT WPDHGVP +ATGLL
Sbjct: 1005 TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLG 1064
Query: 1070 FIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRI 1129
F+R+VK NPP AGPIVVHCSAGAGRTGC+I ID MLDMAE EGVVDI+NCV+ LR++R+
Sbjct: 1065 FVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRV 1124
Query: 1130 NMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNS 1189
N+VQTEEQY+F+HDAILEACLCG TAIPVCEF++ Y+++ R+D QTNSS +KDEFQTLN
Sbjct: 1125 NLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNI 1184
Query: 1190 VTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPA 1249
VTPR++ EDCSI LPRNHDKNR MD+LP DRCLPFLI++DGESSNYINAALMDS++QPA
Sbjct: 1185 VTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPA 1244
Query: 1250 AFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECM 1309
AF+VTQ+PLPNTV DFWRLV+DY C+S+VMLNE+D +Q C QYWPE+ YGPIQVE +
Sbjct: 1245 AFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFV 1304
Query: 1310 SCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQ 1369
S +D D+I+RIFRICN+ RPQ+GY +VQ QY+GW ++R+ P SKRS LK++ ++EKWQ
Sbjct: 1305 SADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQ 1364
Query: 1370 EECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAP 1429
E+ + EGRT++HCLNGGGRSG FCAI V EM+++QN++DVFH VKTLRN+K NMVE
Sbjct: 1365 EQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETL 1424
Query: 1430 EQYRFCYDVALEYLES 1445
EQY+F Y+VALEYL S
Sbjct: 1425 EQYKFVYEVALEYLSS 1440
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 1751 bits (4534), Expect = 0.0
Identities = 847/1475 (57%), Positives = 1088/1475 (73%), Gaps = 46/1475 (3%)
Query: 1 MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDL-YDDFEWVH 59
M + AA AL +LLL P L A+ Q +AGGC+FD+ C Y L + F W
Sbjct: 1 MASLAALAL----SLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQ 56
Query: 60 VSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLN 119
++ E L +P GS+M+V+SS G+KA L LPT+KENDTHCIDF Y S+ +
Sbjct: 57 INTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSS 116
Query: 120 PGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGY 179
PG LN+ V+VN GP NP+WNV+G W++AELA+STFWP+ YQVIFE+ G GY
Sbjct: 117 PGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGY 176
Query: 180 IAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIP 239
IA+D+++VL++PC K+PHFLRL +VEVN GQNATFQCIA G+ + H+KLWLQ+ NG D
Sbjct: 177 IAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTA 236
Query: 240 VAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQ 299
+ T+ +NHRRF+A+ + + + YRCV +S+ GSGVSN+A+LIV+EPP PIAPP+
Sbjct: 237 LMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE 296
Query: 300 LLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEY 359
LL VG TYL I+ NANSIIGDGPIILKEVEYR T+G+W ETH V++P YKLWHLDPD EY
Sbjct: 297 LLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEY 356
Query: 360 EIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITR 419
EIRVLLTRPGEGGTG PGPPL TRTKCA+P+ P+ ++I +I+AR++ + WE GY +TR
Sbjct: 357 EIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTR 416
Query: 420 CHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESE 479
CH++N+T+ Y Y N+ + + ++ + + + L P+ + L+++L+NPEGR ESE
Sbjct: 417 CHSYNLTVQYQYV--FNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE 474
Query: 480 ETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVP 539
E ++QT+EDVPG VP++S+QG FE KI++ WK P + NG+IT YEI+Y ++ S DP+
Sbjct: 475 ELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSAD 534
Query: 540 VAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDY 599
++ V L N THH+F+ L+PGTTY F I+AST KGFGP + T ISAP++P+Y
Sbjct: 535 LSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEY 594
Query: 600 EGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQ 659
+ D LNET TTITV+L+PAQ++GAP+S YQ+VV+E +++R A +EC+ VPV+Y+
Sbjct: 595 D-TDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
Query: 660 NAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEK 719
NA S + +YFAAEL P NLP PFTVGDN+TY G+WNPPL+P K Y+IYFQA+S
Sbjct: 654 NASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANG 713
Query: 720 ETKTQCVRIATKA-------------------AATEEPEVIPDPAKQTDRVVKIAGISAG 760
ETK CVR+ATKA A+T+ + +P KQ D VK+AG+ AG
Sbjct: 714 ETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTV-EPEKQVDNTVKMAGVIAG 772
Query: 761 ILVFILLLLVVILIVKKS----------KLAKKRKDAMGNTRQEMTHMVNAMDRSYADQS 810
+L+FI++LL V+L +K+ KLAKK+K+ ++EM + +A D+ S
Sbjct: 773 LLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASA-DKPTTKLS 831
Query: 811 TLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRV 870
++ S + D + F+ + + + P C+ E Y Q PAIRV
Sbjct: 832 ASRNDEGFSSSSQDVNGFTDGSRGE-LSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRV 890
Query: 871 ADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVIL 930
ADLLQHI MK YGFKEEYE+ EGQ+ASWD AK+D+NR KNRYGNII+YDHSRV L
Sbjct: 891 ADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRL 950
Query: 931 QPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVM 990
++ DP SDYINANYID GY RP HYIATQGP+ ETV DFWRMIWQE SA IVM
Sbjct: 951 LVLDGDPHSDYINANYID------GYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVM 1004
Query: 991 VTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQF 1050
VTNLVEVGRVKC +YWPDDTEVYGD KVT +E EPLAEYV+RTFT++++GY+EIRE++ F
Sbjct: 1005 VTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLF 1064
Query: 1051 HFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAE 1110
HFT WPDHGVP +ATGLL F+R+VK NPP AGPIVVHCSAGAGRTGC+I ID MLDMAE
Sbjct: 1065 HFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAE 1124
Query: 1111 REGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIR 1170
EGVVDI+NCV+ LR++R+N+VQTEEQY+F+HDAILEACLCG TAIPVCEF++ Y+++ R
Sbjct: 1125 NEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISR 1184
Query: 1171 IDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITID 1230
+D QTNSS +KDEFQTLN VTPR++ EDCSI LPRNHDKNR MD+LP DRCLPFLI++D
Sbjct: 1185 LDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVD 1244
Query: 1231 GESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCP 1290
GESSNYINAALMDS++QPAAF+VTQ+PLPNTV DFWRLV+DY C+S+VMLNE+D +Q C
Sbjct: 1245 GESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCM 1304
Query: 1291 QYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHRE 1350
QYWPE+ YGPIQVE +S +D D+I+RIFRICN+ RPQ+GY +VQ QY+GW ++R+
Sbjct: 1305 QYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRD 1364
Query: 1351 VPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVD 1410
P SKRS LK++ ++EKWQE+ + EGRT++HCLNGGGRSG FCAI V EM+++QN++D
Sbjct: 1365 TPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIID 1424
Query: 1411 VFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445
VFH VKTLRN+K NMVE EQY+F Y+VALEYL S
Sbjct: 1425 VFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1459
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 514 bits (1324), Expect = e-145
Identities = 379/1147 (33%), Positives = 563/1147 (49%), Gaps = 147/1147 (12%)
Query: 335 GSWTETHAVNAPTYKLWHLDPDTEYEIRVL-LTRPGEGGTGLPGPPLITRTKCAEPMRTP 393
G+W + + ++ + L D Y +RVL T G+G P+ +T+ P + P
Sbjct: 464 GNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLS---DPIQVKTQQGVPGQ-P 519
Query: 394 KTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHV 453
L+ I + W ++ FR + + DP +V
Sbjct: 520 MNLRAEARSETSITLSWSPPRQE-------SIIKYELLFREGDHGREVGRTFDPTT-SYV 571
Query: 454 VNHLPPYTNVSLKMILTNPEGRKESEETIIQ-TDEDV-PGPVPVKSLQGTSFENKIFLNW 511
V L P T + ++ +P+G + Q T + + P VK + TS + L+W
Sbjct: 572 VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTS----VLLSW 627
Query: 512 KEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFI 571
+ P + N T Y+I Y+ + T+ +T + HL P T Y F +
Sbjct: 628 EFPDNYNSP-TPYKIQYNGL--------------TLDVDGRTTKKLITHLKPHTFYNFVL 672
Query: 572 --RASTVKGFGPATAINVTTNI-----SAPTLPDYEGVDASLNETATTITVLLRPAQAKG 624
R S++ G N+ S PD +G I V L Q+
Sbjct: 673 TNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF----------IMVYLPDGQSP- 721
Query: 625 APISAYQIVVEELHPHRTKR---EAGAMECYQVPVTYQNA-------------MSGGAPY 668
P+ +Y IV+ L R + G+ E + Q+ + PY
Sbjct: 722 VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPY 781
Query: 669 YFA--AELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCV 726
A + LPP F GD + Y GF N L P Y ++ A+ + T
Sbjct: 782 IAARFSVLPP-------TFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFA--- 831
Query: 727 RIATKAAATEEPEVI--PDPAKQTDRVVKIAGISAGILVFILLLLVVI-LIVKKSKLAKK 783
A+ +P + PDP D + + +L + ++ +VI +++ K+K K
Sbjct: 832 -----ASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSK 886
Query: 784 RKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSR 843
RKD+ T+ + + AD + H +DP+ M + NF
Sbjct: 887 RKDSEPRTKCLLNN---------ADLAPHHPKDPVE---MRRINFQ-------------- 920
Query: 844 LLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASW 903
P L HP I +AD+ +H +K +DS +EYES GQ +W
Sbjct: 921 ---TPGMLS------------HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTW 965
Query: 904 DVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYI 963
+ + + N+ KNRY N+IAYDHSRVILQP+E SDYINANY+D GY+ + YI
Sbjct: 966 EHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVD------GYRCQNAYI 1019
Query: 964 ATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVE 1022
ATQGP+ ET DFWRM+W+++SA IVM+T L E R+KC +YWP+ TE YG +VT ++
Sbjct: 1020 ATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLD 1079
Query: 1023 MEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSA 1082
LA + VRTF+L + G +E REV+QF FT WPDHGVP + T L+F+RRVK NPP A
Sbjct: 1080 TIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDA 1139
Query: 1083 GPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIH 1142
GPIVVHCSAG GRTGC+IVID ML+ + E VD+Y V +RS+R MVQTE+QY FIH
Sbjct: 1140 GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIH 1199
Query: 1143 DAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIA 1202
+A+LEA CG T +P A + +++ + + ++ EF+ L + A
Sbjct: 1200 EALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFISA 1257
Query: 1203 CLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNT 1261
LP N KNR ++++P + L I G E S+YINA+ +D YRQ A+I TQ PL T
Sbjct: 1258 NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAET 1317
Query: 1262 VKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVIN 1319
+DFWR++++ T +VML ++ + C QYWP E RY V+ M+ + ++
Sbjct: 1318 TEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQ 1374
Query: 1320 RIFRICNLTRPQEGY-LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGR 1378
I R +T ++G V+QFQ+ W + VP S F+ I QV K +E+ + +G
Sbjct: 1375 YILREFKVTDARDGQSRTVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGP 1432
Query: 1379 TIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDV 1438
+HC G GR+G+F + IV+E ++ + VVD+F VK LR +P MV+ ++Y+FCY
Sbjct: 1433 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQA 1492
Query: 1439 ALEYLES 1445
ALEYL S
Sbjct: 1493 ALEYLGS 1499
Score = 66.6 bits (161), Expect = 2e-10
Identities = 91/402 (22%), Positives = 150/402 (37%), Gaps = 69/402 (17%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRNG----EDIPVAQTKNINHRRFAASFRLQEV 260
E+ G N C+A G + K W+Q +D+PV +N+ L+
Sbjct: 246 EIMPGGNVNITCVAVGSPMPYVK-WMQGAEDLTPEDDMPVG--RNV----------LELT 292
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
D Y CV S G + AQ+ V+ P+ P + T + I ++ +
Sbjct: 293 DVKDSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---P 348
Query: 321 GPIILKEVEYRMTS--GSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ +EY+ S G + + Y + L P++EYEI V + G G P
Sbjct: 349 DPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSE 406
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
++TRT P P+ ++ + A + V WE GY + +T
Sbjct: 407 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRV--YYTMEPEHPVG 464
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP 490
++ HN +D V + L T + T+ S+ ++T + VP
Sbjct: 465 NWQKHN--------VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP 516
Query: 491 GPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSS-------IRSFDPAVPVAGP 543
G P+ E I L+W P + I +YE+ + R+FDP
Sbjct: 517 GQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP------- 566
Query: 544 PQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAI 585
+T +V L P T Y F + A + +G G T +
Sbjct: 567 ---------TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV 599
Score = 47.4 bits (111), Expect = 1e-04
Identities = 96/449 (21%), Positives = 167/449 (37%), Gaps = 59/449 (13%)
Query: 206 VNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQ 265
V + AT C A+G W + D P A I R A +++ +TDQ
Sbjct: 146 VERTRTATMLCAASGNPDPEIT-WFKDFLPVD-PSASNGRIKQLRSGA-LQIESSEETDQ 202
Query: 266 DLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIIL 325
Y CV + G S+ A L VRE ++ V P + ++ ++ + I+ G + +
Sbjct: 203 GKYECVATNSAGVRYSSPANLYVRELR------EVRRVAPRFSILPMS-HEIMPGGNVNI 255
Query: 326 KEVEYRMTSGSWTETHAVNAPT-YKLW-----HLDPDTEYEI--RVL-LTRPGEGG---- 372
V AV +P Y W L P+ + + VL LT +
Sbjct: 256 TCV-------------AVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTC 302
Query: 373 ---TGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICY 429
+ L + + + P T + E A I + W+S + +
Sbjct: 303 VAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIE----- 357
Query: 430 HYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDED 488
++ ++ + D ++ + L P + + + N G+ SE + +T E
Sbjct: 358 --YKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQ 415
Query: 489 VPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVS 548
P P + + W+EP++PNG+I Y + Y + +P PV +
Sbjct: 416 APASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYY----TMEPEHPVGNWQK--H 469
Query: 549 NLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP-ATAINVTTNISAPTLPDYEGVDASLN 607
N+ +S L TY + A T G GP + I V T P P +A
Sbjct: 470 NVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA--- 526
Query: 608 ETATTITVLLRPAQAKGAPISAYQIVVEE 636
+ T+IT+ P + + I Y+++ E
Sbjct: 527 RSETSITLSWSPPRQES--IIKYELLFRE 553
Score = 32.3 bits (72), Expect = 3.4
Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 193 DKSPHFLRLGDVEVN-AGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRF 251
++ P F++ ++ +G A+F C ATG D W + G+ + + + I
Sbjct: 30 EEPPRFIKEPKDQIGVSGGVASFVCQATG-DPKPRVTW--NKKGKKVNSQRFETIEFDES 86
Query: 252 A-ASFRLQEV-TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLL 309
A A R+Q + T D+++Y CV Q+ G + ++RE P P + +GP +
Sbjct: 87 AGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPN-IDMGPQLKV 145
Query: 310 IQ 311
++
Sbjct: 146 VE 147
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 514 bits (1324), Expect = e-145
Identities = 379/1147 (33%), Positives = 563/1147 (49%), Gaps = 147/1147 (12%)
Query: 335 GSWTETHAVNAPTYKLWHLDPDTEYEIRVL-LTRPGEGGTGLPGPPLITRTKCAEPMRTP 393
G+W + + ++ + L D Y +RVL T G+G P+ +T+ P + P
Sbjct: 460 GNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLS---DPIQVKTQQGVPGQ-P 515
Query: 394 KTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHV 453
L+ I + W ++ FR + + DP +V
Sbjct: 516 MNLRAEARSETSITLSWSPPRQE-------SIIKYELLFREGDHGREVGRTFDPTT-SYV 567
Query: 454 VNHLPPYTNVSLKMILTNPEGRKESEETIIQ-TDEDV-PGPVPVKSLQGTSFENKIFLNW 511
V L P T + ++ +P+G + Q T + + P VK + TS + L+W
Sbjct: 568 VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTS----VLLSW 623
Query: 512 KEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFI 571
+ P + N T Y+I Y+ + T+ +T + HL P T Y F +
Sbjct: 624 EFPDNYNSP-TPYKIQYNGL--------------TLDVDGRTTKKLITHLKPHTFYNFVL 668
Query: 572 --RASTVKGFGPATAINVTTNI-----SAPTLPDYEGVDASLNETATTITVLLRPAQAKG 624
R S++ G N+ S PD +G I V L Q+
Sbjct: 669 TNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF----------IMVYLPDGQSP- 717
Query: 625 APISAYQIVVEELHPHRTKR---EAGAMECYQVPVTYQNA-------------MSGGAPY 668
P+ +Y IV+ L R + G+ E + Q+ + PY
Sbjct: 718 VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPY 777
Query: 669 YFA--AELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCV 726
A + LPP F GD + Y GF N L P Y ++ A+ + T
Sbjct: 778 IAARFSVLPP-------TFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFA--- 827
Query: 727 RIATKAAATEEPEVI--PDPAKQTDRVVKIAGISAGILVFILLLLVVI-LIVKKSKLAKK 783
A+ +P + PDP D + + +L + ++ +VI +++ K+K K
Sbjct: 828 -----ASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSK 882
Query: 784 RKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSR 843
RKD+ T+ + + AD + H +DP+ M + NF
Sbjct: 883 RKDSEPRTKCLLNN---------ADLAPHHPKDPVE---MRRINFQ-------------- 916
Query: 844 LLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASW 903
P L HP I +AD+ +H +K +DS +EYES GQ +W
Sbjct: 917 ---TPGMLS------------HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTW 961
Query: 904 DVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYI 963
+ + + N+ KNRY N+IAYDHSRVILQP+E SDYINANY+D GY+ + YI
Sbjct: 962 EHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVD------GYRCQNAYI 1015
Query: 964 ATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVE 1022
ATQGP+ ET DFWRM+W+++SA IVM+T L E R+KC +YWP+ TE YG +VT ++
Sbjct: 1016 ATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLD 1075
Query: 1023 MEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSA 1082
LA + VRTF+L + G +E REV+QF FT WPDHGVP + T L+F+RRVK NPP A
Sbjct: 1076 TIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDA 1135
Query: 1083 GPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIH 1142
GPIVVHCSAG GRTGC+IVID ML+ + E VD+Y V +RS+R MVQTE+QY FIH
Sbjct: 1136 GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIH 1195
Query: 1143 DAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIA 1202
+A+LEA CG T +P A + +++ + + ++ EF+ L + A
Sbjct: 1196 EALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFISA 1253
Query: 1203 CLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNT 1261
LP N KNR ++++P + L I G E S+YINA+ +D YRQ A+I TQ PL T
Sbjct: 1254 NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAET 1313
Query: 1262 VKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVIN 1319
+DFWR++++ T +VML ++ + C QYWP E RY V+ M+ + ++
Sbjct: 1314 TEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQ 1370
Query: 1320 RIFRICNLTRPQEGY-LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGR 1378
I R +T ++G V+QFQ+ W + VP S F+ I QV K +E+ + +G
Sbjct: 1371 YILREFKVTDARDGQSRTVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGP 1428
Query: 1379 TIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDV 1438
+HC G GR+G+F + IV+E ++ + VVD+F VK LR +P MV+ ++Y+FCY
Sbjct: 1429 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQA 1488
Query: 1439 ALEYLES 1445
ALEYL S
Sbjct: 1489 ALEYLGS 1495
Score = 66.6 bits (161), Expect = 2e-10
Identities = 91/402 (22%), Positives = 150/402 (37%), Gaps = 69/402 (17%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRNG----EDIPVAQTKNINHRRFAASFRLQEV 260
E+ G N C+A G + K W+Q +D+PV +N+ L+
Sbjct: 242 EIMPGGNVNITCVAVGSPMPYVK-WMQGAEDLTPEDDMPVG--RNV----------LELT 288
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
D Y CV S G + AQ+ V+ P+ P + T + I ++ +
Sbjct: 289 DVKDSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---P 344
Query: 321 GPIILKEVEYRMTS--GSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ +EY+ S G + + Y + L P++EYEI V + G G P
Sbjct: 345 DPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSE 402
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
++TRT P P+ ++ + A + V WE GY + +T
Sbjct: 403 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRV--YYTMEPEHPVG 460
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP 490
++ HN +D V + L T + T+ S+ ++T + VP
Sbjct: 461 NWQKHN--------VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP 512
Query: 491 GPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSS-------IRSFDPAVPVAGP 543
G P+ E I L+W P + I +YE+ + R+FDP
Sbjct: 513 GQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP------- 562
Query: 544 PQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAI 585
+T +V L P T Y F + A + +G G T +
Sbjct: 563 ---------TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV 595
Score = 46.2 bits (108), Expect = 2e-04
Identities = 53/248 (21%), Positives = 96/248 (38%), Gaps = 20/248 (8%)
Query: 391 RTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAP 450
+ P T + E A I + W+S + + ++ ++ + D
Sbjct: 320 KAPGTPMVTENTATSITITWDSGNPDPVSYYVIE-------YKSKSQDGPYQIKEDITTT 372
Query: 451 QHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFL 509
++ + L P + + + N G+ SE + +T E P P + +
Sbjct: 373 RYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIV 432
Query: 510 NWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQF 569
W+EP++PNG+I Y + Y + +P PV + N+ +S L TY
Sbjct: 433 QWEEPVEPNGLIRGYRVYY----TMEPEHPVGNWQK--HNVDDSLLTTVGSLLEDETYTV 486
Query: 570 FIRASTVKGFGP-ATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPIS 628
+ A T G GP + I V T P P +A + T+IT+ P + + I
Sbjct: 487 RVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA---RSETSITLSWSPPRQES--II 541
Query: 629 AYQIVVEE 636
Y+++ E
Sbjct: 542 KYELLFRE 549
Score = 32.3 bits (72), Expect = 3.4
Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 193 DKSPHFLRLGDVEVN-AGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRF 251
++ P F++ ++ +G A+F C ATG D W + G+ + + + I
Sbjct: 30 EEPPRFIKEPKDQIGVSGGVASFVCQATG-DPKPRVTW--NKKGKKVNSQRFETIEFDES 86
Query: 252 A-ASFRLQEV-TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLL 309
A A R+Q + T D+++Y CV Q+ G + ++RE P P + +GP +
Sbjct: 87 AGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPN-IDMGPQLKV 145
Query: 310 IQ 311
++
Sbjct: 146 VE 147
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 510 bits (1313), Expect = e-144
Identities = 352/1000 (35%), Positives = 514/1000 (51%), Gaps = 130/1000 (13%)
Query: 486 DEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQ 545
D+ P VK + TS + L+W+ P + N T Y+I Y+ +
Sbjct: 1033 DQVSPKNFKVKMIMKTS----VLLSWEFPDNYNSP-TPYKIQYNGL-------------- 1073
Query: 546 TVSNLWNSTHHVFMHLHPGTTYQFFI--RASTVKGFGPATAINVTTNI-----SAPTLPD 598
T+ +T + HL P T Y F + R S++ G N+ S PD
Sbjct: 1074 TLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPD 1133
Query: 599 YEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKR---EAGAMECYQVP 655
+G I V L Q+ P+ +Y IV+ L R + G+ E +
Sbjct: 1134 ADGF----------IMVYLPDGQSP-VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLE 1182
Query: 656 VTYQNA-------------MSGGAPYYFA--AELPPGNLPEPAPFTVGDNRTYQGFWNPP 700
Q+ + PY A + LPP F GD + Y GF N
Sbjct: 1183 ELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPP-------TFHPGDQKQYGGFDNRG 1235
Query: 701 LAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI--PDPAKQTDRVVKIAGIS 758
L P Y ++ A+ + T A+ +P + PDP D + +
Sbjct: 1236 LEPGHRYVLFVLAVLQKSEPTFA--------ASPFSDPFQLDNPDPQPIVDGEEGLIWVI 1287
Query: 759 AGILVFILLLLVVI-LIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDP 817
+L + ++ +VI +++ K+K KRKD+ T+ + + AD + H +DP
Sbjct: 1288 GPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN---------ADLAPHHPKDP 1338
Query: 818 LSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP-------YQTGQLHPAIRV 870
+ M + NF T +S G SP +++ HP I +
Sbjct: 1339 VE---MRRINFQ--------TPDS------------GLRSPLREPGFHFESMLSHPPIPI 1375
Query: 871 ADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVIL 930
AD+ +H +K +DS +EYES GQ +W+ + + N+ KNRY N+IAYDHSRVIL
Sbjct: 1376 ADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVIL 1435
Query: 931 QPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVM 990
QP+E SDYINANY+D GY+ + YIATQGP+ ET DFWRM+W+++SA IVM
Sbjct: 1436 QPIEGIMGSDYINANYVD------GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVM 1489
Query: 991 VTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQ 1049
+T L E R+KC +YWP+ TE YG +VT ++ LA + VRTF+L + G +E REV+Q
Sbjct: 1490 MTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1549
Query: 1050 FHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMA 1109
F FT WPDHGVP + T L+F+RRVK NPP AGPIVVHCSAG GRTGC+IVID ML+
Sbjct: 1550 FQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI 1609
Query: 1110 EREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMI 1169
+ E VD+Y V +RS+R MVQTE+QY FIH+A+LEA CG T +P A +
Sbjct: 1610 KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA 1669
Query: 1170 RIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITI 1229
+++ + + ++ EF+ L + A LP N KNR ++++P + L I
Sbjct: 1670 QVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1727
Query: 1230 DG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--S 1286
G E S+YINA+ +D YRQ A+I TQ PL T +DFWR++++ T +VML ++
Sbjct: 1728 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGR 1787
Query: 1287 QGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY-LMVQQFQYLGW 1345
+ C QYWP E RY V+ M+ + ++ I R +T ++G V+QFQ+ W
Sbjct: 1788 EKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1844
Query: 1346 ASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKR 1405
+ VP S F+ I QV K +E+ + +G +HC G GR+G+F + IV+E ++
Sbjct: 1845 -PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVFITLSIVLERMRY 1902
Query: 1406 QNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445
+ VVD+F VK LR +P MV+ ++Y+FCY ALEYL S
Sbjct: 1903 EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1942
Score = 72.8 bits (177), Expect = 2e-12
Identities = 100/450 (22%), Positives = 167/450 (37%), Gaps = 70/450 (15%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRNG----EDIPVAQTKNINHRRFAASFRLQEV 260
E+ G N C+A G + K W+Q +D+PV +N+ L+
Sbjct: 255 EIMPGGNVNITCVAVGSPMPYVK-WMQGAEDLTPEDDMPVG--RNV----------LELT 301
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
D Y CV S G + AQ+ V+ P+ P + T + I ++ +
Sbjct: 302 DVKDSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---P 357
Query: 321 GPIILKEVEYRMTS--GSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ +EY+ S G + + Y + L P++EYEI V + G G P
Sbjct: 358 DPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSE 415
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
++TRT P P+ ++ + A + V WE GY + +T
Sbjct: 416 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRV--YYTMEPEHPVG 473
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP 490
++ HN +D V + L T + T+ S+ ++T + VP
Sbjct: 474 NWQKHN--------VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP 525
Query: 491 GPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSS-------IRSFDPAVPVAGP 543
G P+ E I L+W P + I +YE+ + R+FDP
Sbjct: 526 GQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP------- 575
Query: 544 PQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPAT-AINVTTNISAPTLPDYEGV 602
+T +V L P T Y F + A + +G G T + T S P+ P +
Sbjct: 576 ---------TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVK 626
Query: 603 DASLNETATTITVLLRPAQAKGAPISAYQI 632
S+ TA ++ P + + Y +
Sbjct: 627 CVSVRSTAILVSWRPPPPETHNGALVGYSV 656
Score = 62.0 bits (149), Expect = 4e-09
Identities = 62/277 (22%), Positives = 104/277 (37%), Gaps = 23/277 (8%)
Query: 347 TYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRI 406
+Y + L P+TEY R+ P G G P + RT ++P P+ +K +++ I
Sbjct: 578 SYVVEDLKPNTEYAFRLAARSPQ--GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAI 635
Query: 407 AVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLK 466
V W ++ Y + + + P Q ++ L +T +
Sbjct: 636 LVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRIT 695
Query: 467 MILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLD--PNGIITQ 523
+ G ES +++TDEDVP P K I + W+ P +G I
Sbjct: 696 TVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRG 755
Query: 524 YEISYSSIRSFDPAVPVAGPPQTVSNL-----WNST-----HHVFMHLHPGTTYQFFIRA 573
Y++ Y + + GPP+ + W + V +L P T Y + A
Sbjct: 756 YQVHYVRMEGAE----ARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAA 811
Query: 574 STVKGFG----PATAINVTTNISAPTLPDYEGVDASL 606
T+KG G P + + PTL + + SL
Sbjct: 812 YTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSL 848
Score = 48.9 bits (115), Expect = 4e-05
Identities = 67/334 (20%), Positives = 119/334 (35%), Gaps = 37/334 (11%)
Query: 260 VTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIG 319
V +TD+D+ + ++ A ++ P AP + G Y + +
Sbjct: 712 VVRTDEDVPSAPPRKVEAEALNATAIRVLWRSP---APGRQHGQIRGYQVHYVRMEGAEA 768
Query: 320 DGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLL-TRPGEGGTGLPGP 378
GP +K+V M + + ET + +L P+T Y I V T G+G P
Sbjct: 769 RGPPRIKDV---MLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKV 825
Query: 379 PLITRTKCAEP----MRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRG 434
+ P +TP+ +A + + + LGY + F
Sbjct: 826 VVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQ-------------FGR 872
Query: 435 HNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP-GPV 493
+ + L+ P ++ + + ++ + G E ++ ED P G
Sbjct: 873 EDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHP 932
Query: 494 PVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYSSIRSFDPA----VPVAGPPQTV 547
+ G + + L W P+ + NG I +Y ++ + PA +P A P
Sbjct: 933 QILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAE 992
Query: 548 SNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP 581
+ L L P T Y +RA T +G GP
Sbjct: 993 NAL------TLQGLKPDTAYDLQVRAHTRRGPGP 1020
Score = 46.2 bits (108), Expect = 2e-04
Identities = 53/248 (21%), Positives = 96/248 (38%), Gaps = 20/248 (8%)
Query: 391 RTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAP 450
+ P T + E A I + W+S + + ++ ++ + D
Sbjct: 333 KAPGTPMVTENTATSITITWDSGNPDPVSYYVIE-------YKSKSQDGPYQIKEDITTT 385
Query: 451 QHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFL 509
++ + L P + + + N G+ SE + +T E P P + +
Sbjct: 386 RYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIV 445
Query: 510 NWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQF 569
W+EP++PNG+I Y + Y + +P PV + N+ +S L TY
Sbjct: 446 QWEEPVEPNGLIRGYRVYY----TMEPEHPVGNWQK--HNVDDSLLTTVGSLLEDETYTV 499
Query: 570 FIRASTVKGFGP-ATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPIS 628
+ A T G GP + I V T P P +A + T+IT+ P + + I
Sbjct: 500 RVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA---RSETSITLSWSPPRQES--II 554
Query: 629 AYQIVVEE 636
Y+++ E
Sbjct: 555 KYELLFRE 562
Score = 42.0 bits (97), Expect = 0.004
Identities = 104/431 (24%), Positives = 159/431 (36%), Gaps = 68/431 (15%)
Query: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE---PPRPIAPPQ---LLGVGPTY 307
S+ ++++ + +R +S +G G +VR+ +P APPQ + V T
Sbjct: 578 SYVVEDLKPNTEYAFRLAARSPQGLGAFT---PVVRQRTLQSKPSAPPQDVKCVSVRSTA 634
Query: 308 LLIQLNANSI-IGDGPIILKEVEYRMTSGSWTETHAVNA--PTYK---LWHLDPDTEYEI 361
+L+ +G ++ V YR E VN PT L L+ T+Y
Sbjct: 635 ILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQY-- 692
Query: 362 RVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCH 421
R+ E G G P++ RT P P+ ++ + A I V W S R H
Sbjct: 693 RITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPG--RQH 750
Query: 422 TFNVTICYHYFRGHNE-------------SKADCLDMDPKAPQHVVNHLPPYTNVSLKMI 468
HY R + A D + V+ +L P T S+ +
Sbjct: 751 GQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVA 810
Query: 469 LTNPEG-RKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEIS 527
+G S+ ++ T V G P S+Q T E + W EP P G +
Sbjct: 811 AYTMKGDGARSKPKVVVTKGAVLGR-PTLSVQQTP-EGSLLARW-EP--PAGTAEDQVLG 865
Query: 528 YSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA--- 584
Y + + P+A T+ + + +H G TY F + A + G G A
Sbjct: 866 YRLQFGREDSTPLA----TLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVL 921
Query: 585 -INVTTNISAPTLPDYEGVDASLNETATTITVLLR-----PAQAKGAPISAYQIVVEELH 638
I T P + + G A+ TVLLR PA+ GA I Y + V
Sbjct: 922 SIPEDTPRGHPQILEAAG-------NASAGTVLLRWLPPVPAERNGA-IVKYTVAV---- 969
Query: 639 PHRTKREAGAM 649
REAGA+
Sbjct: 970 -----REAGAL 975
Score = 34.3 bits (77), Expect = 0.89
Identities = 38/134 (28%), Positives = 57/134 (42%), Gaps = 21/134 (15%)
Query: 339 ETHAVNAPTYKLWHLDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLK 397
E A NA T L L PDT Y+++V TR G G PP+ RT + + +PK K
Sbjct: 988 EPGAENALT--LQGLKPDTAYDLQVRAHTRRGPGPFS---PPVRYRTFLRDQV-SPKNFK 1041
Query: 398 IAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHL 457
+ I + + WE +N Y + LD+D + + ++ HL
Sbjct: 1042 VKMIMKTSVLLSWEFPD-------NYNSPTPYKI-----QYNGLTLDVDGRTTKKLITHL 1089
Query: 458 PPYTNVSLKMILTN 471
P+T +LTN
Sbjct: 1090 KPHT--FYNFVLTN 1101
Score = 32.3 bits (72), Expect = 3.4
Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 193 DKSPHFLRLGDVEVN-AGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRF 251
++ P F++ ++ +G A+F C ATG D W + G+ + + + I
Sbjct: 30 EEPPRFIKEPKDQIGVSGGVASFVCQATG-DPKPRVTW--NKKGKKVNSQRFETIEFDES 86
Query: 252 A-ASFRLQEV-TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLL 309
A A R+Q + T D+++Y CV Q+ G + ++RE P P + +GP +
Sbjct: 87 AGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPN-IDMGPQLKV 145
Query: 310 IQ 311
++
Sbjct: 146 VE 147
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 506 bits (1304), Expect = e-143
Identities = 349/993 (35%), Positives = 507/993 (51%), Gaps = 132/993 (13%)
Query: 486 DEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQ 545
D+ P VK + TS + L+W+ P + N T Y+I Y+ +
Sbjct: 1011 DQVSPKNFKVKMIMKTS----VLLSWEFPDNYNSP-TPYKIQYNGL-------------- 1051
Query: 546 TVSNLWNSTHHVFMHLHPGTTYQFFI--RASTVKGFGPATAINVTTNI-----SAPTLPD 598
T+ +T + HL P T Y F + R S++ G N+ S PD
Sbjct: 1052 TLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPD 1111
Query: 599 YEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKR---EAGAMECYQVP 655
+G I V L Q+ P+ +Y IV+ L R + G+ E +
Sbjct: 1112 ADGF----------IMVYLPDGQSP-VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLE 1160
Query: 656 VTYQNA-------------MSGGAPYYFA--AELPPGNLPEPAPFTVGDNRTYQGFWNPP 700
Q+ + PY A + LPP F GD + Y GF N
Sbjct: 1161 ELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPP-------TFHPGDQKQYGGFDNRG 1213
Query: 701 LAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI--PDPAKQTDRVVKIAGIS 758
L P Y ++ A+ + T A+ +P + PDP D + +
Sbjct: 1214 LEPGHRYVLFVLAVLQKSEPTFA--------ASPFSDPFQLDNPDPQPIVDGEEGLIWVI 1265
Query: 759 AGILVFILLLLVVI-LIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDP 817
+L + ++ +VI +++ K+K KRKD+ T+ + + AD + H +DP
Sbjct: 1266 GPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN---------ADLAPHHPKDP 1316
Query: 818 LSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHI 877
+ M + NF P L HP I +AD+ +H
Sbjct: 1317 VE---MRRINFQ-----------------TPGMLS------------HPPIPIADMAEHT 1344
Query: 878 NLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDP 937
+K +DS +EYES GQ +W+ + + N+ KNRY N+IAYDHSRVILQP+E
Sbjct: 1345 ERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIM 1404
Query: 938 SSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEV 997
SDYINANY+D GY+ + YIATQGP+ ET DFWRM+W+++SA IVM+T L E
Sbjct: 1405 GSDYINANYVD------GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEK 1458
Query: 998 GRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWP 1056
R+KC +YWP+ TE YG +VT ++ LA + VRTF+L + G +E REV+QF FT WP
Sbjct: 1459 SRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWP 1518
Query: 1057 DHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVD 1116
DHGVP + T L+F+RRVK NPP AGPIVVHCSAG GRTGC+IVID ML+ + E VD
Sbjct: 1519 DHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVD 1578
Query: 1117 IYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTN 1176
+Y V +RS+R MVQTE+QY FIH+A+LEA CG T +P A + +++ +
Sbjct: 1579 VYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEH 1638
Query: 1177 SSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSN 1235
+ ++ EF+ L + A LP N KNR ++++P + L I G E S+
Sbjct: 1639 VTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSD 1696
Query: 1236 YINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYW 1293
YINA+ +D YRQ A+I TQ PL T +DFWR++++ T +VML ++ + C QYW
Sbjct: 1697 YINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYW 1756
Query: 1294 PEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY-LMVQQFQYLGWASHREVP 1352
P E RY V+ M+ + ++ I R +T ++G V+QFQ+ W + VP
Sbjct: 1757 PAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQSRTVRQFQFTDW-PEQGVP 1812
Query: 1353 GSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVF 1412
S F+ I QV K +E+ + +G +HC G GR+G+F + IV+E ++ + VVD+F
Sbjct: 1813 KSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF 1871
Query: 1413 HAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445
VK LR +P MV+ ++Y+FCY ALEYL S
Sbjct: 1872 QTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1904
Score = 72.8 bits (177), Expect = 2e-12
Identities = 100/450 (22%), Positives = 167/450 (37%), Gaps = 70/450 (15%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRNG----EDIPVAQTKNINHRRFAASFRLQEV 260
E+ G N C+A G + K W+Q +D+PV +N+ L+
Sbjct: 242 EIMPGGNVNITCVAVGSPMPYVK-WMQGAEDLTPEDDMPVG--RNV----------LELT 288
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
D Y CV S G + AQ+ V+ P+ P + T + I ++ +
Sbjct: 289 DVKDSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---P 344
Query: 321 GPIILKEVEYRMTS--GSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ +EY+ S G + + Y + L P++EYEI V + G G P
Sbjct: 345 DPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSE 402
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
++TRT P P+ ++ + A + V WE GY + +T
Sbjct: 403 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRV--YYTMEPEHPVG 460
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP 490
++ HN +D V + L T + T+ S+ ++T + VP
Sbjct: 461 NWQKHN--------VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP 512
Query: 491 GPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSS-------IRSFDPAVPVAGP 543
G P+ E I L+W P + I +YE+ + R+FDP
Sbjct: 513 GQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP------- 562
Query: 544 PQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPAT-AINVTTNISAPTLPDYEGV 602
+T +V L P T Y F + A + +G G T + T S P+ P +
Sbjct: 563 ---------TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVK 613
Query: 603 DASLNETATTITVLLRPAQAKGAPISAYQI 632
S+ TA ++ P + + Y +
Sbjct: 614 CVSVRSTAILVSWRPPPPETHNGALVGYSV 643
Score = 46.2 bits (108), Expect = 2e-04
Identities = 53/248 (21%), Positives = 96/248 (38%), Gaps = 20/248 (8%)
Query: 391 RTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAP 450
+ P T + E A I + W+S + + ++ ++ + D
Sbjct: 320 KAPGTPMVTENTATSITITWDSGNPDPVSYYVIE-------YKSKSQDGPYQIKEDITTT 372
Query: 451 QHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFL 509
++ + L P + + + N G+ SE + +T E P P + +
Sbjct: 373 RYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIV 432
Query: 510 NWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQF 569
W+EP++PNG+I Y + Y + +P PV + N+ +S L TY
Sbjct: 433 QWEEPVEPNGLIRGYRVYY----TMEPEHPVGNWQK--HNVDDSLLTTVGSLLEDETYTV 486
Query: 570 FIRASTVKGFGP-ATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPIS 628
+ A T G GP + I V T P P +A + T+IT+ P + + I
Sbjct: 487 RVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA---RSETSITLSWSPPRQES--II 541
Query: 629 AYQIVVEE 636
Y+++ E
Sbjct: 542 KYELLFRE 549
Score = 45.4 bits (106), Expect = 4e-04
Identities = 101/420 (24%), Positives = 157/420 (37%), Gaps = 55/420 (13%)
Query: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE---PPRPIAPPQ---LLGVGPTY 307
S+ ++++ + +R +S +G G +VR+ +P APPQ + V T
Sbjct: 565 SYVVEDLKPNTEYAFRLAARSPQGLGAFT---PVVRQRTLQSKPSAPPQDVKCVSVRSTA 621
Query: 308 LLIQLNANSI-IGDGPIILKEVEYRMTSGSWTETHAVNA--PTYK---LWHLDPDTEYEI 361
+L+ +G ++ V YR E VN PT L L+ T+Y
Sbjct: 622 ILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQY-- 679
Query: 362 RVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCH 421
R+ E G G P++ RT P P+ ++ + A I V W S
Sbjct: 680 RITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQ 739
Query: 422 TFNVTICYHYFRGHNESKADCLD--MDPKAPQHVVNHLPPYTNVSLKMILTNPEG-RKES 478
+ Y G + M A + V+ +L P T S+ + +G S
Sbjct: 740 IRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARS 799
Query: 479 EETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAV 538
+ ++ T V G P S+Q T E + W EP P G + Y + +
Sbjct: 800 KPKVVVTKGAVLGR-PTLSVQQTP-EGSLLARW-EP--PAGTAEDQVLGYRLQFGREDST 854
Query: 539 PVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA----INVTTNISAP 594
P+A T+ + + +H G TY F + A + G G A I T P
Sbjct: 855 PLA----TLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHP 910
Query: 595 TLPDYEGVDASLNETATTITVLLR-----PAQAKGAPISAYQIVVEELHPHRTKREAGAM 649
+ + G A+ TVLLR PA+ GA I Y + V REAGA+
Sbjct: 911 QILEAAG-------NASAGTVLLRWLPPVPAERNGA-IVKYTVAV---------REAGAL 953
Score = 45.4 bits (106), Expect = 4e-04
Identities = 50/242 (20%), Positives = 86/242 (35%), Gaps = 31/242 (12%)
Query: 352 HLDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEP----MRTPKTLKIAEIQARRI 406
+L P+T Y I V T G+G P + P +TP+ +A +
Sbjct: 776 NLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAG 835
Query: 407 AVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLK 466
+ + LGY + F + + L+ P ++ + + +
Sbjct: 836 TAEDQVLGYRLQ-------------FGREDSTPLATLEFPPSEDRYTASGVHKGATYVFR 882
Query: 467 MILTNPEGRKESEETIIQTDEDVP-GPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQ 523
+ + G E ++ ED P G + G + + L W P+ + NG I +
Sbjct: 883 LAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVK 942
Query: 524 YEISYSSIRSFDPA----VPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGF 579
Y ++ + PA +P A P + L L P T Y +RA T +G
Sbjct: 943 YTVAVREAGALGPARETELPAAAEPGAENAL------TLQGLKPDTAYDLQVRAHTRRGP 996
Query: 580 GP 581
GP
Sbjct: 997 GP 998
Score = 34.3 bits (77), Expect = 0.89
Identities = 38/134 (28%), Positives = 57/134 (42%), Gaps = 21/134 (15%)
Query: 339 ETHAVNAPTYKLWHLDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLK 397
E A NA T L L PDT Y+++V TR G G PP+ RT + + +PK K
Sbjct: 966 EPGAENALT--LQGLKPDTAYDLQVRAHTRRGPGPFS---PPVRYRTFLRDQV-SPKNFK 1019
Query: 398 IAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHL 457
+ I + + WE +N Y + LD+D + + ++ HL
Sbjct: 1020 VKMIMKTSVLLSWEFPD-------NYNSPTPYKI-----QYNGLTLDVDGRTTKKLITHL 1067
Query: 458 PPYTNVSLKMILTN 471
P+T +LTN
Sbjct: 1068 KPHT--FYNFVLTN 1079
Score = 32.3 bits (72), Expect = 3.4
Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 193 DKSPHFLRLGDVEVN-AGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRF 251
++ P F++ ++ +G A+F C ATG D W + G+ + + + I
Sbjct: 30 EEPPRFIKEPKDQIGVSGGVASFVCQATG-DPKPRVTW--NKKGKKVNSQRFETIEFDES 86
Query: 252 A-ASFRLQEV-TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLL 309
A A R+Q + T D+++Y CV Q+ G + ++RE P P + +GP +
Sbjct: 87 AGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPN-IDMGPQLKV 145
Query: 310 IQ 311
++
Sbjct: 146 VE 147
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 503 bits (1295), Expect = e-142
Identities = 302/772 (39%), Positives = 431/772 (55%), Gaps = 73/772 (9%)
Query: 682 PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741
P FT+GD++ Y GF N L + Y ++F E+K AT + +
Sbjct: 1200 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 1254
Query: 742 PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKL-AKKRKDAMGNTRQEMTHM 798
DP TD + + +L VFI+ +++ IL+ K+ + + RK ++ N ++ +H
Sbjct: 1255 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH- 1313
Query: 799 VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP 858
H DP+ + R N +S
Sbjct: 1314 --------------HPTDPVEL----------RRLNFQTPGMAS---------------- 1333
Query: 859 YQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYG 918
HP I + +L HI +K +D+ F +EYES GQ +W+ + + N+ KNRY
Sbjct: 1334 ------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYA 1387
Query: 919 NIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWR 978
N+IAYDHSRV+L +E P SDY+NANYID GY++ + YIATQG + ET DFWR
Sbjct: 1388 NVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSLPETFGDFWR 1441
Query: 979 MIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLE 1037
MIW+++SA +VM+T L E RVKC +YWP TE +G +VT ++ LA Y VRTF L
Sbjct: 1442 MIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALY 1501
Query: 1038 RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTG 1097
+ G +E REV+QF FT WPDHGVP H T L+F+RRVK NPP AGP+VVHCSAG GRTG
Sbjct: 1502 KNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1561
Query: 1098 CYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIP 1157
C+IVID ML+ + E VDIY V +R++R MVQTE+QYIFIHDA+LEA CG T +P
Sbjct: 1562 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVP 1621
Query: 1158 VCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDML 1217
A + +I++ N + ++ EF+ L S + A LP N KNR ++++
Sbjct: 1622 ARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLVNIM 1679
Query: 1218 PPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTS 1276
P + L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR+++++ T
Sbjct: 1680 PYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI 1739
Query: 1277 IVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY 1334
+VML ++ + C QYWP E RY V+ M+ + ++ I R +T ++G
Sbjct: 1740 VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQ 1796
Query: 1335 -LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMF 1393
V+QFQ+ W + VP S F+ I QV K +E+ + +G +HC G GR+G+F
Sbjct: 1797 SRTVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVF 1854
Query: 1394 CAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445
+ IV+E ++ + VVD+F VK LR +P MV+ +QY+F Y ALEYL S
Sbjct: 1855 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1906
Score = 69.7 bits (169), Expect = 2e-11
Identities = 94/444 (21%), Positives = 174/444 (39%), Gaps = 58/444 (13%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260
E+ G + C+A G + K L + +D+P+ + +N R +A+
Sbjct: 246 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 299
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Y CV S G + AQ+ V+ P+P P + T + + ++ +
Sbjct: 300 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 348
Query: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ ++++ + + E V Y + L P ++YE RV+ G G P
Sbjct: 349 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 406
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
P++T+T P P+ ++ + + I V W+ GY + +T + T +
Sbjct: 407 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 464
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489
+ HN + + + +L P S+K++ T+ S + + T V
Sbjct: 465 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515
Query: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
PG P+ E I L+W P + I YE+ Y G Q ++
Sbjct: 516 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 563
Query: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDYEGVDASLNE 608
+ T + L P + Y F + A + +G G +TA I+ T S P+ P + S +
Sbjct: 564 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSS 623
Query: 609 TATTITVLLRPAQAKGAPISAYQI 632
T+ ++ P + + I+ Y I
Sbjct: 624 TSILVSWQPPPVEKQNGIITEYSI 647
Score = 62.4 bits (150), Expect = 3e-09
Identities = 86/385 (22%), Positives = 145/385 (37%), Gaps = 44/385 (11%)
Query: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE-PPRPIAPPQLLGV---GPTYLL 309
S+RLQ + +R +S +G G S A++ R +P APPQ + T +L
Sbjct: 569 SYRLQGLKPNSLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSIL 627
Query: 310 IQLNANSIIGDGPIILK-EVEYRMTSGSWTETHAV-----NAPTYKLWHLDPDTEYEIRV 363
+ + II + ++Y G + H + + Y L L+ TEY R+
Sbjct: 628 VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RI 685
Query: 364 LLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTF 423
+T + G G ++ RT P P+ +++ + + + V W S N
Sbjct: 686 TVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIR 745
Query: 424 NVTICYHYFRGHN-ESKADCLDMD----------PKAPQH--VVNHLPPYTNVSLKMILT 470
+ HY R N E K + D +H +++ L P T+ SL +
Sbjct: 746 GYQV--HYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAY 803
Query: 471 NPEG-RKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYS 529
+G S+ ++ T VPG P + T N + W P+D G + Y + +
Sbjct: 804 TTKGDGARSKPKLVSTTGAVPGK-PRLVINHTQM-NTALIQWHPPVDTFGPLQGYRLKFG 861
Query: 530 SIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTT 589
+ +P T+ H +H G +Y F + A GFG ++
Sbjct: 862 R-KDMEPLT-------TLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI 913
Query: 590 NISAPTLPDYEGVDASLNETATTIT 614
PT G +L+ TT T
Sbjct: 914 PEEVPT-----GFPQNLHSEGTTST 933
Score = 60.5 bits (145), Expect = 1e-08
Identities = 95/420 (22%), Positives = 158/420 (37%), Gaps = 54/420 (12%)
Query: 234 NGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE--- 290
N I ++++I + ++++ ++DQ Y CV + G+ S A L VRE
Sbjct: 171 NNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELRE 230
Query: 291 ----PPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWT--ETHAVN 344
PPR PP + P +N + P + V++ + + T + +
Sbjct: 231 VRRVPPRFSIPPTNHEIMPGG---SVNITCVAVGSP--MPYVKWMLGAEDLTPEDDMPIG 285
Query: 345 APTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQAR 404
+L + Y + T L I + + P T + E A
Sbjct: 286 RNVLELNDVRQSANYTCVAMST--------LGVIEAIAQITVKALPKPPGTPVVTESTAT 337
Query: 405 RIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCL--DMDPKAP-QHVVNHLPPYT 461
I + W+S N +Y H ++ L ++D A ++ V L PY+
Sbjct: 338 SITLTWDS----------GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYS 387
Query: 462 NVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGI 520
+ +++ N GR SE + QT E P P I + WKEP +PNG
Sbjct: 388 DYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ 447
Query: 521 ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580
I Y + Y + DP V N+ +S +L P TY + A T G G
Sbjct: 448 IQGYRVYY----TMDPTQHVNN--WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG 501
Query: 581 PATA-INVTTNISAPTLPDYEGVDASLN---ETATTITVLLRPAQAKGAPISAYQIVVEE 636
P ++ I V T P P LN E + ++LL + I+ Y++V ++
Sbjct: 502 PLSSDIQVITQTGVPGQP--------LNFKAEPESETSILLSWTPPRSDTIANYELVYKD 553
Score = 45.8 bits (107), Expect = 3e-04
Identities = 58/235 (24%), Positives = 82/235 (34%), Gaps = 26/235 (11%)
Query: 353 LDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES 412
L P+T Y + V T G G P + T A P + L I Q + W
Sbjct: 790 LQPETSYSLTV--TAYTTKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWHP 845
Query: 413 LGYNITRCHTFNVTICYHYFRGHNESKA-DCLDMDPKAPQHVVNHLPPYTNVSLKMILTN 471
TF Y G + + L+ K + + ++ N
Sbjct: 846 ------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARN 899
Query: 472 PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYS 529
G E I E+VP P + + L+W+ P+ + NGIIT+Y + Y
Sbjct: 900 KVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR 959
Query: 530 SIRSFDPAVPVAG---PPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP 581
I P +P+ P T L L P TTY +RA T KG GP
Sbjct: 960 DINI--PLLPMEQLIVPADTTMTLTG--------LKPDTTYDVKVRAHTSKGPGP 1004
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 503 bits (1295), Expect = e-142
Identities = 302/772 (39%), Positives = 431/772 (55%), Gaps = 73/772 (9%)
Query: 682 PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741
P FT+GD++ Y GF N L + Y ++F E+K AT + +
Sbjct: 1187 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 1241
Query: 742 PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKL-AKKRKDAMGNTRQEMTHM 798
DP TD + + +L VFI+ +++ IL+ K+ + + RK ++ N ++ +H
Sbjct: 1242 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH- 1300
Query: 799 VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP 858
H DP+ + R N +S
Sbjct: 1301 --------------HPTDPVEL----------RRLNFQTPGMAS---------------- 1320
Query: 859 YQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYG 918
HP I + +L HI +K +D+ F +EYES GQ +W+ + + N+ KNRY
Sbjct: 1321 ------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYA 1374
Query: 919 NIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWR 978
N+IAYDHSRV+L +E P SDY+NANYID GY++ + YIATQG + ET DFWR
Sbjct: 1375 NVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSLPETFGDFWR 1428
Query: 979 MIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLE 1037
MIW+++SA +VM+T L E RVKC +YWP TE +G +VT ++ LA Y VRTF L
Sbjct: 1429 MIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALY 1488
Query: 1038 RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTG 1097
+ G +E REV+QF FT WPDHGVP H T L+F+RRVK NPP AGP+VVHCSAG GRTG
Sbjct: 1489 KNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1548
Query: 1098 CYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIP 1157
C+IVID ML+ + E VDIY V +R++R MVQTE+QYIFIHDA+LEA CG T +P
Sbjct: 1549 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVP 1608
Query: 1158 VCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDML 1217
A + +I++ N + ++ EF+ L S + A LP N KNR ++++
Sbjct: 1609 ARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLVNIM 1666
Query: 1218 PPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTS 1276
P + L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR+++++ T
Sbjct: 1667 PYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI 1726
Query: 1277 IVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY 1334
+VML ++ + C QYWP E RY V+ M+ + ++ I R +T ++G
Sbjct: 1727 VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQ 1783
Query: 1335 -LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMF 1393
V+QFQ+ W + VP S F+ I QV K +E+ + +G +HC G GR+G+F
Sbjct: 1784 SRTVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVF 1841
Query: 1394 CAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445
+ IV+E ++ + VVD+F VK LR +P MV+ +QY+F Y ALEYL S
Sbjct: 1842 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1893
Score = 69.7 bits (169), Expect = 2e-11
Identities = 94/444 (21%), Positives = 174/444 (39%), Gaps = 58/444 (13%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260
E+ G + C+A G + K L + +D+P+ + +N R +A+
Sbjct: 233 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 286
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Y CV S G + AQ+ V+ P+P P + T + + ++ +
Sbjct: 287 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 335
Query: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ ++++ + + E V Y + L P ++YE RV+ G G P
Sbjct: 336 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 393
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
P++T+T P P+ ++ + + I V W+ GY + +T + T +
Sbjct: 394 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 451
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489
+ HN + + + +L P S+K++ T+ S + + T V
Sbjct: 452 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 502
Query: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
PG P+ E I L+W P + I YE+ Y G Q ++
Sbjct: 503 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 550
Query: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDYEGVDASLNE 608
+ T + L P + Y F + A + +G G +TA I+ T S P+ P + S +
Sbjct: 551 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSS 610
Query: 609 TATTITVLLRPAQAKGAPISAYQI 632
T+ ++ P + + I+ Y I
Sbjct: 611 TSILVSWQPPPVEKQNGIITEYSI 634
Score = 62.4 bits (150), Expect = 3e-09
Identities = 86/385 (22%), Positives = 145/385 (37%), Gaps = 44/385 (11%)
Query: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE-PPRPIAPPQLLGV---GPTYLL 309
S+RLQ + +R +S +G G S A++ R +P APPQ + T +L
Sbjct: 556 SYRLQGLKPNSLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSIL 614
Query: 310 IQLNANSIIGDGPIILK-EVEYRMTSGSWTETHAV-----NAPTYKLWHLDPDTEYEIRV 363
+ + II + ++Y G + H + + Y L L+ TEY R+
Sbjct: 615 VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RI 672
Query: 364 LLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTF 423
+T + G G ++ RT P P+ +++ + + + V W S N
Sbjct: 673 TVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIR 732
Query: 424 NVTICYHYFRGHN-ESKADCLDMD----------PKAPQH--VVNHLPPYTNVSLKMILT 470
+ HY R N E K + D +H +++ L P T+ SL +
Sbjct: 733 GYQV--HYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAY 790
Query: 471 NPEG-RKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYS 529
+G S+ ++ T VPG P + T N + W P+D G + Y + +
Sbjct: 791 TTKGDGARSKPKLVSTTGAVPGK-PRLVINHTQM-NTALIQWHPPVDTFGPLQGYRLKFG 848
Query: 530 SIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTT 589
+ +P T+ H +H G +Y F + A GFG ++
Sbjct: 849 R-KDMEPLT-------TLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI 900
Query: 590 NISAPTLPDYEGVDASLNETATTIT 614
PT G +L+ TT T
Sbjct: 901 PEEVPT-----GFPQNLHSEGTTST 920
Score = 58.9 bits (141), Expect = 3e-08
Identities = 103/447 (23%), Positives = 166/447 (37%), Gaps = 59/447 (13%)
Query: 206 VNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHR---RFAASFRLQEVTK 262
V + AT C A+G W + D T N N R + + ++++ +
Sbjct: 137 VERTRTATMLCAASGNPDPEIT-WFK-----DFLPVDTSNNNGRIKQLRSGALQIEQSEE 190
Query: 263 TDQDLYRCVTQSERGSGVSNFAQLIVRE---PPRPIAPPQLLGVGPTYLLIQLNANSIIG 319
+DQ Y CV + G+ S A L VR PPR PP + P +N +
Sbjct: 191 SDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGG---SVNITCVAV 247
Query: 320 DGPIILKEVEYRMTSGSWT--ETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPG 377
P + V++ + + T + + +L + Y + T L
Sbjct: 248 GSP--MPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMST--------LGV 297
Query: 378 PPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNE 437
I + + P T + E A I + W+S N +Y H
Sbjct: 298 IEAIAQITVKALPKPPGTPVVTESTATSITLTWDS----------GNPEPVSYYIIQHKP 347
Query: 438 SKADCL--DMDPKAP-QHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPV 493
++ L ++D A ++ V L PY++ +++ N GR SE + QT E P
Sbjct: 348 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 407
Query: 494 PVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNS 553
P I + WKEP +PNG I Y + Y + DP V N+ +S
Sbjct: 408 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNN--WMKHNVADS 461
Query: 554 THHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDYEGVDASLN---ET 609
+L P TY + A T G GP ++ I V T P P LN E
Sbjct: 462 QITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP--------LNFKAEP 513
Query: 610 ATTITVLLRPAQAKGAPISAYQIVVEE 636
+ ++LL + I+ Y++V ++
Sbjct: 514 ESETSILLSWTPPRSDTIANYELVYKD 540
Score = 45.8 bits (107), Expect = 3e-04
Identities = 58/235 (24%), Positives = 82/235 (34%), Gaps = 26/235 (11%)
Query: 353 LDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES 412
L P+T Y + V T G G P + T A P + L I Q + W
Sbjct: 777 LQPETSYSLTV--TAYTTKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWHP 832
Query: 413 LGYNITRCHTFNVTICYHYFRGHNESKA-DCLDMDPKAPQHVVNHLPPYTNVSLKMILTN 471
TF Y G + + L+ K + + ++ N
Sbjct: 833 ------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARN 886
Query: 472 PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYS 529
G E I E+VP P + + L+W+ P+ + NGIIT+Y + Y
Sbjct: 887 KVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR 946
Query: 530 SIRSFDPAVPVAG---PPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP 581
I P +P+ P T L L P TTY +RA T KG GP
Sbjct: 947 DINI--PLLPMEQLIVPADTTMTLTG--------LKPDTTYDVKVRAHTSKGPGP 991
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 503 bits (1295), Expect = e-142
Identities = 302/772 (39%), Positives = 431/772 (55%), Gaps = 73/772 (9%)
Query: 682 PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741
P FT+GD++ Y GF N L + Y ++F E+K AT + +
Sbjct: 1191 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 1245
Query: 742 PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKL-AKKRKDAMGNTRQEMTHM 798
DP TD + + +L VFI+ +++ IL+ K+ + + RK ++ N ++ +H
Sbjct: 1246 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH- 1304
Query: 799 VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP 858
H DP+ + R N +S
Sbjct: 1305 --------------HPTDPVEL----------RRLNFQTPGMAS---------------- 1324
Query: 859 YQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYG 918
HP I + +L HI +K +D+ F +EYES GQ +W+ + + N+ KNRY
Sbjct: 1325 ------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYA 1378
Query: 919 NIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWR 978
N+IAYDHSRV+L +E P SDY+NANYID GY++ + YIATQG + ET DFWR
Sbjct: 1379 NVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSLPETFGDFWR 1432
Query: 979 MIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLE 1037
MIW+++SA +VM+T L E RVKC +YWP TE +G +VT ++ LA Y VRTF L
Sbjct: 1433 MIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALY 1492
Query: 1038 RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTG 1097
+ G +E REV+QF FT WPDHGVP H T L+F+RRVK NPP AGP+VVHCSAG GRTG
Sbjct: 1493 KNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1552
Query: 1098 CYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIP 1157
C+IVID ML+ + E VDIY V +R++R MVQTE+QYIFIHDA+LEA CG T +P
Sbjct: 1553 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVP 1612
Query: 1158 VCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDML 1217
A + +I++ N + ++ EF+ L S + A LP N KNR ++++
Sbjct: 1613 ARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLVNIM 1670
Query: 1218 PPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTS 1276
P + L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR+++++ T
Sbjct: 1671 PYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI 1730
Query: 1277 IVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY 1334
+VML ++ + C QYWP E RY V+ M+ + ++ I R +T ++G
Sbjct: 1731 VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQ 1787
Query: 1335 -LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMF 1393
V+QFQ+ W + VP S F+ I QV K +E+ + +G +HC G GR+G+F
Sbjct: 1788 SRTVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVF 1845
Query: 1394 CAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445
+ IV+E ++ + VVD+F VK LR +P MV+ +QY+F Y ALEYL S
Sbjct: 1846 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1897
Score = 69.7 bits (169), Expect = 2e-11
Identities = 94/444 (21%), Positives = 174/444 (39%), Gaps = 58/444 (13%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260
E+ G + C+A G + K L + +D+P+ + +N R +A+
Sbjct: 246 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 299
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Y CV S G + AQ+ V+ P+P P + T + + ++ +
Sbjct: 300 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 348
Query: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ ++++ + + E V Y + L P ++YE RV+ G G P
Sbjct: 349 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 406
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
P++T+T P P+ ++ + + I V W+ GY + +T + T +
Sbjct: 407 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 464
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489
+ HN + + + +L P S+K++ T+ S + + T V
Sbjct: 465 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515
Query: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
PG P+ E I L+W P + I YE+ Y G Q ++
Sbjct: 516 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 563
Query: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDYEGVDASLNE 608
+ T + L P + Y F + A + +G G +TA I+ T S P+ P + S +
Sbjct: 564 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSS 623
Query: 609 TATTITVLLRPAQAKGAPISAYQI 632
T+ ++ P + + I+ Y I
Sbjct: 624 TSILVSWQPPPVEKQNGIITEYSI 647
Score = 67.0 bits (162), Expect = 1e-10
Identities = 86/376 (22%), Positives = 144/376 (38%), Gaps = 35/376 (9%)
Query: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE-PPRPIAPPQLLGV---GPTYLL 309
S+RLQ + +R +S +G G S A++ R +P APPQ + T +L
Sbjct: 569 SYRLQGLKPNSLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSIL 627
Query: 310 IQLNANSIIGDGPIILK-EVEYRMTSGSWTETHAV-----NAPTYKLWHLDPDTEYEIRV 363
+ + II + ++Y G + H + + Y L L+ TEY R+
Sbjct: 628 VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RI 685
Query: 364 LLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTF 423
+T + G G ++ RT P P+ +++ + + + V W S N
Sbjct: 686 TVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIR 745
Query: 424 NVTICYHYFRGHN-ESKADCLDMD---PKAPQHVVNHLPPYTNVSLKMILTNPEG-RKES 478
+ HY R N E K + D A +++ L P T+ SL + +G S
Sbjct: 746 GYQV--HYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARS 803
Query: 479 EETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAV 538
+ ++ T VPG P + T N + W P+D G + Y + + + +P
Sbjct: 804 KPKLVSTTGAVPGK-PRLVINHTQM-NTALIQWHPPVDTFGPLQGYRLKFGR-KDMEPLT 860
Query: 539 PVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPD 598
T+ H +H G +Y F + A GFG ++ PT
Sbjct: 861 -------TLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT--- 910
Query: 599 YEGVDASLNETATTIT 614
G +L+ TT T
Sbjct: 911 --GFPQNLHSEGTTST 924
Score = 60.5 bits (145), Expect = 1e-08
Identities = 95/420 (22%), Positives = 158/420 (37%), Gaps = 54/420 (12%)
Query: 234 NGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE--- 290
N I ++++I + ++++ ++DQ Y CV + G+ S A L VRE
Sbjct: 171 NNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELRE 230
Query: 291 ----PPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWT--ETHAVN 344
PPR PP + P +N + P + V++ + + T + +
Sbjct: 231 VRRVPPRFSIPPTNHEIMPGG---SVNITCVAVGSP--MPYVKWMLGAEDLTPEDDMPIG 285
Query: 345 APTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQAR 404
+L + Y + T L I + + P T + E A
Sbjct: 286 RNVLELNDVRQSANYTCVAMST--------LGVIEAIAQITVKALPKPPGTPVVTESTAT 337
Query: 405 RIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCL--DMDPKAP-QHVVNHLPPYT 461
I + W+S N +Y H ++ L ++D A ++ V L PY+
Sbjct: 338 SITLTWDS----------GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYS 387
Query: 462 NVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGI 520
+ +++ N GR SE + QT E P P I + WKEP +PNG
Sbjct: 388 DYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ 447
Query: 521 ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580
I Y + Y + DP V N+ +S +L P TY + A T G G
Sbjct: 448 IQGYRVYY----TMDPTQHVNN--WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG 501
Query: 581 PATA-INVTTNISAPTLPDYEGVDASLN---ETATTITVLLRPAQAKGAPISAYQIVVEE 636
P ++ I V T P P LN E + ++LL + I+ Y++V ++
Sbjct: 502 PLSSDIQVITQTGVPGQP--------LNFKAEPESETSILLSWTPPRSDTIANYELVYKD 553
Score = 45.8 bits (107), Expect = 3e-04
Identities = 58/235 (24%), Positives = 82/235 (34%), Gaps = 26/235 (11%)
Query: 353 LDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES 412
L P+T Y + V T G G P + T A P + L I Q + W
Sbjct: 781 LQPETSYSLTV--TAYTTKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWHP 836
Query: 413 LGYNITRCHTFNVTICYHYFRGHNESKA-DCLDMDPKAPQHVVNHLPPYTNVSLKMILTN 471
TF Y G + + L+ K + + ++ N
Sbjct: 837 ------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARN 890
Query: 472 PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYS 529
G E I E+VP P + + L+W+ P+ + NGIIT+Y + Y
Sbjct: 891 KVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR 950
Query: 530 SIRSFDPAVPVAG---PPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP 581
I P +P+ P T L L P TTY +RA T KG GP
Sbjct: 951 DINI--PLLPMEQLIVPADTTMTLTG--------LKPDTTYDVKVRAHTSKGPGP 995
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 503 bits (1295), Expect = e-142
Identities = 302/772 (39%), Positives = 431/772 (55%), Gaps = 73/772 (9%)
Query: 682 PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741
P FT+GD++ Y GF N L + Y ++F E+K AT + +
Sbjct: 789 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 843
Query: 742 PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKL-AKKRKDAMGNTRQEMTHM 798
DP TD + + +L VFI+ +++ IL+ K+ + + RK ++ N ++ +H
Sbjct: 844 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH- 902
Query: 799 VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP 858
H DP+ + R N +S
Sbjct: 903 --------------HPTDPVEL----------RRLNFQTPGMAS---------------- 922
Query: 859 YQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYG 918
HP I + +L HI +K +D+ F +EYES GQ +W+ + + N+ KNRY
Sbjct: 923 ------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYA 976
Query: 919 NIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWR 978
N+IAYDHSRV+L +E P SDY+NANYID GY++ + YIATQG + ET DFWR
Sbjct: 977 NVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSLPETFGDFWR 1030
Query: 979 MIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLE 1037
MIW+++SA +VM+T L E RVKC +YWP TE +G +VT ++ LA Y VRTF L
Sbjct: 1031 MIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALY 1090
Query: 1038 RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTG 1097
+ G +E REV+QF FT WPDHGVP H T L+F+RRVK NPP AGP+VVHCSAG GRTG
Sbjct: 1091 KNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1150
Query: 1098 CYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIP 1157
C+IVID ML+ + E VDIY V +R++R MVQTE+QYIFIHDA+LEA CG T +P
Sbjct: 1151 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVP 1210
Query: 1158 VCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDML 1217
A + +I++ N + ++ EF+ L S + A LP N KNR ++++
Sbjct: 1211 ARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLVNIM 1268
Query: 1218 PPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTS 1276
P + L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR+++++ T
Sbjct: 1269 PYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI 1328
Query: 1277 IVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY 1334
+VML ++ + C QYWP E RY V+ M+ + ++ I R +T ++G
Sbjct: 1329 VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQ 1385
Query: 1335 -LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMF 1393
V+QFQ+ W + VP S F+ I QV K +E+ + +G +HC G GR+G+F
Sbjct: 1386 SRTVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVF 1443
Query: 1394 CAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445
+ IV+E ++ + VVD+F VK LR +P MV+ +QY+F Y ALEYL S
Sbjct: 1444 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1495
Score = 62.0 bits (149), Expect = 4e-09
Identities = 87/407 (21%), Positives = 158/407 (38%), Gaps = 62/407 (15%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260
E+ G + C+A G + K L + +D+P+ + +N R +A+
Sbjct: 246 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 299
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Y CV S G + AQ+ V+ P+P P + T + + ++ +
Sbjct: 300 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 348
Query: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ ++++ + + E V Y + L P ++YE RV+ G G P
Sbjct: 349 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 406
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
P++T+T P P+ ++ + + I V W+ GY + +T + T +
Sbjct: 407 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 464
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489
+ HN + + + +L P S+K++ T+ S + + T V
Sbjct: 465 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515
Query: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
PG P+ E I L+W P + I YE+ Y G Q ++
Sbjct: 516 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 563
Query: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTL 596
+ T + L P + Y F + A + +G G +TA ISA T+
Sbjct: 564 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTA-----EISARTM 605
Score = 60.5 bits (145), Expect = 1e-08
Identities = 95/420 (22%), Positives = 158/420 (37%), Gaps = 54/420 (12%)
Query: 234 NGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE--- 290
N I ++++I + ++++ ++DQ Y CV + G+ S A L VRE
Sbjct: 171 NNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELRE 230
Query: 291 ----PPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWT--ETHAVN 344
PPR PP + P +N + P + V++ + + T + +
Sbjct: 231 VRRVPPRFSIPPTNHEIMPGG---SVNITCVAVGSP--MPYVKWMLGAEDLTPEDDMPIG 285
Query: 345 APTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQAR 404
+L + Y + T L I + + P T + E A
Sbjct: 286 RNVLELNDVRQSANYTCVAMST--------LGVIEAIAQITVKALPKPPGTPVVTESTAT 337
Query: 405 RIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCL--DMDPKAP-QHVVNHLPPYT 461
I + W+S N +Y H ++ L ++D A ++ V L PY+
Sbjct: 338 SITLTWDS----------GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYS 387
Query: 462 NVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGI 520
+ +++ N GR SE + QT E P P I + WKEP +PNG
Sbjct: 388 DYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ 447
Query: 521 ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580
I Y + Y + DP V N+ +S +L P TY + A T G G
Sbjct: 448 IQGYRVYY----TMDPTQHVNN--WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG 501
Query: 581 PATA-INVTTNISAPTLPDYEGVDASLN---ETATTITVLLRPAQAKGAPISAYQIVVEE 636
P ++ I V T P P LN E + ++LL + I+ Y++V ++
Sbjct: 502 PLSSDIQVITQTGVPGQP--------LNFKAEPESETSILLSWTPPRSDTIANYELVYKD 553
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 501 bits (1289), Expect = e-141
Identities = 303/776 (39%), Positives = 430/776 (55%), Gaps = 77/776 (9%)
Query: 682 PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741
P FT+GD++ Y GF N L + Y ++F E+K AT + +
Sbjct: 786 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 840
Query: 742 PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKLAKK-----RKDAMGNTRQE 794
DP TD + + +L VFI+ +++ IL+ K K+ RK ++ N ++
Sbjct: 841 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEI 900
Query: 795 MTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEG 854
+H H DP+ + R N +S
Sbjct: 901 PSH---------------HPTDPVEL----------RRLNFQTPGMAS------------ 923
Query: 855 TESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAK 914
HP I + +L HI +K +D+ F +EYES GQ +W+ + + N+ K
Sbjct: 924 ----------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPK 973
Query: 915 NRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVY 974
NRY N+IAYDHSRV+L +E P SDY+NANYID GY++ + YIATQG + ET
Sbjct: 974 NRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSLPETFG 1027
Query: 975 DFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRT 1033
DFWRMIW+++SA +VM+T L E RVKC +YWP TE +G +VT ++ LA Y VRT
Sbjct: 1028 DFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRT 1087
Query: 1034 FTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGA 1093
F L + G +E REV+QF FT WPDHGVP H T L+F+RRVK NPP AGP+VVHCSAG
Sbjct: 1088 FALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGV 1147
Query: 1094 GRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGE 1153
GRTGC+IVID ML+ + E VDIY V +R++R MVQTE+QYIFIHDA+LEA CG
Sbjct: 1148 GRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGN 1207
Query: 1154 TAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRF 1213
T +P A + +I++ N + ++ EF+ L S + A LP N KNR
Sbjct: 1208 TEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRL 1265
Query: 1214 MDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDY 1272
++++P + L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR+++++
Sbjct: 1266 VNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEH 1325
Query: 1273 GCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRP 1330
T +VML ++ + C QYWP E RY V+ M+ + ++ I R +T
Sbjct: 1326 NSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDA 1382
Query: 1331 QEGY-LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGR 1389
++G V+QFQ+ W + VP S F+ I QV K +E+ + +G +HC G GR
Sbjct: 1383 RDGQSRTVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGR 1440
Query: 1390 SGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445
+G+F + IV+E ++ + VVD+F VK LR +P MV+ +QY+F Y ALEYL S
Sbjct: 1441 TGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1496
Score = 62.0 bits (149), Expect = 4e-09
Identities = 87/407 (21%), Positives = 158/407 (38%), Gaps = 62/407 (15%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260
E+ G + C+A G + K L + +D+P+ + +N R +A+
Sbjct: 243 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 296
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Y CV S G + AQ+ V+ P+P P + T + + ++ +
Sbjct: 297 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 345
Query: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ ++++ + + E V Y + L P ++YE RV+ G G P
Sbjct: 346 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 403
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
P++T+T P P+ ++ + + I V W+ GY + +T + T +
Sbjct: 404 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 461
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489
+ HN + + + +L P S+K++ T+ S + + T V
Sbjct: 462 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 512
Query: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
PG P+ E I L+W P + I YE+ Y G Q ++
Sbjct: 513 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 560
Query: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTL 596
+ T + L P + Y F + A + +G G +TA ISA T+
Sbjct: 561 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTA-----EISARTM 602
Score = 58.9 bits (141), Expect = 3e-08
Identities = 92/400 (23%), Positives = 151/400 (37%), Gaps = 54/400 (13%)
Query: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE-------PPRPIAPPQLLGVGPT 306
+ ++++ ++DQ Y CV + G+ S A L VRE PPR PP + P
Sbjct: 188 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPG 247
Query: 307 YLLIQLNANSIIGDGPIILKEVEYRMTSGSWT--ETHAVNAPTYKLWHLDPDTEYEIRVL 364
+N + P + V++ + + T + + +L + Y +
Sbjct: 248 G---SVNITCVAVGSP--MPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAM 302
Query: 365 LTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFN 424
T L I + + P T + E A I + W+S N
Sbjct: 303 ST--------LGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS----------GN 344
Query: 425 VTICYHYFRGHNESKADCL--DMDPKAP-QHVVNHLPPYTNVSLKMILTNPEGR-KESEE 480
+Y H ++ L ++D A ++ V L PY++ +++ N GR SE
Sbjct: 345 PEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEP 404
Query: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV 540
+ QT E P P I + WKEP +PNG I Y + Y + DP V
Sbjct: 405 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHV 460
Query: 541 AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDY 599
N+ +S +L P TY + A T G GP ++ I V T P P
Sbjct: 461 NN--WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP-- 516
Query: 600 EGVDASLN---ETATTITVLLRPAQAKGAPISAYQIVVEE 636
LN E + ++LL + I+ Y++V ++
Sbjct: 517 ------LNFKAEPESETSILLSWTPPRSDTIANYELVYKD 550
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 499 bits (1286), Expect = e-141
Identities = 300/784 (38%), Positives = 443/784 (56%), Gaps = 75/784 (9%)
Query: 669 YFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRI 728
Y AA+L LPE FT+GD + Y+GF+N PL+P Y + A + K
Sbjct: 1186 YVAAQLDV--LPET--FTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYA--- 1238
Query: 729 ATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAM 788
+ ++E V PA+Q + ++ ++ +L IL++L+VI I+ L K+++
Sbjct: 1239 --SSPYSDEIVVQVTPAQQQEEP-EMLWVTGPVLAVILIILIVIAIL----LFKRKRTHS 1291
Query: 789 GNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVP 848
+++ E + + D H+ DP+ + ++
Sbjct: 1292 PSSKDEQSIGLK-------DSLLAHSSDPVEMRRLN------------------------ 1320
Query: 849 RYLCEGTESPYQTGQL--HPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVA 906
YQT + HP I + DL +I +K +D F +EYES GQ +W+ +
Sbjct: 1321 ----------YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENS 1370
Query: 907 KKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQ 966
+ N+ KNRY N+IAYDHSRVIL ++ P SDYINANYID GY++ + YIATQ
Sbjct: 1371 NLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYID------GYRKQNAYIATQ 1424
Query: 967 GPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEP 1025
GP+ ET+ DFWRM+W++++A +VM+T L E RVKC +YWP TE G +VT ++
Sbjct: 1425 GPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVE 1484
Query: 1026 LAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPI 1085
LA Y VRTF L + G +E RE++QF F WPDHGVP + T +L+F+RRVK NP AGP+
Sbjct: 1485 LATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPM 1544
Query: 1086 VVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAI 1145
VVHCSAG GRTGC+IVID ML+ + E VDIY V +RS+R MVQTE+QY+FIH+A+
Sbjct: 1545 VVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEAL 1604
Query: 1146 LEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLP 1205
LEA CG T +P A + ++ + + ++ EF+ L S + A LP
Sbjct: 1605 LEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLAS--SKAHTSRFISANLP 1662
Query: 1206 RNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKD 1264
N KNR ++++P + L I G E S+YINA+ +D YRQ A+I TQ PL + +D
Sbjct: 1663 CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTED 1722
Query: 1265 FWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIF 1322
FWR+++++ T IVML ++ + C QYWP E RY V+ M+ + ++ I
Sbjct: 1723 FWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYIL 1779
Query: 1323 RICNLTRPQEGY-LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTII 1381
R +T ++G ++QFQ+ W + VP + F+ I QV K +E+ + +G +
Sbjct: 1780 REFKVTDARDGQSRTIRQFQFTDW-PEQGVPKTGEGFIDFIGQVHKTKEQFGQ-DGPITV 1837
Query: 1382 HCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE 1441
HC G GR+G+F + IV+E ++ + VVD+F VKTLR +P MV+ +QY+ CY ALE
Sbjct: 1838 HCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE 1897
Query: 1442 YLES 1445
YL S
Sbjct: 1898 YLGS 1901
Score = 72.0 bits (175), Expect = 4e-12
Identities = 106/447 (23%), Positives = 172/447 (38%), Gaps = 57/447 (12%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWL----QRRNGEDIPVAQTKNINHRRFAASFRLQEV 260
EV G + C+A G + K W+ + +++PV +N+ L V
Sbjct: 242 EVMPGGSVNLTCVAVGAPMPYVK-WMMGAEELTKEDEMPVG--RNV--------LELSNV 290
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
++ Y CV S G + AQ+ V+ P+P P L+ T + L +S +
Sbjct: 291 VRSAN--YTCVAISSLGM-IEATAQVTVKALPKP--PIDLVVTETTATSVTLTWDSGNSE 345
Query: 321 GPIILKEVEYRM--TSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ ++YR T G + E V Y + L P +EY RVL G G P
Sbjct: 346 -PVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV--NSIGRGPPSE 402
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
+ RT P P+ ++ + A + V WE GY + +T + +
Sbjct: 403 AVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV--YYTPDSRRPPN 460
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETI-IQTDEDV 489
+ HN + A L V L P SL+++ G TI ++T + V
Sbjct: 461 AWHKHN-TDAGLLT--------TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGV 511
Query: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
P P + +I L+W P P I YE+ Y + D V P
Sbjct: 512 PAQ-PADFQAEVESDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKVTFDP----- 563
Query: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPAT-AINVTTNISAPTLPDYEGVDASLNE 608
++ + L P T Y+F + A + G G T I T S P+ P + + S+
Sbjct: 564 ---TSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGS 620
Query: 609 TATTITVLLRPAQAKGAPISAYQIVVE 635
T ++ + PA ++ I+ Y + E
Sbjct: 621 TTVRVSWVPPPADSRNGVITQYSVAYE 647
Score = 58.5 bits (140), Expect = 4e-08
Identities = 66/257 (25%), Positives = 96/257 (37%), Gaps = 46/257 (17%)
Query: 353 LDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDW- 410
L P+T Y + V T G+G P I T A P R T+ I+ + W
Sbjct: 787 LTPETTYSVTVAAYTTKGDGARS---KPKIVTTTGAVPGRP--TMMISTTAMNTALLQWH 841
Query: 411 -------ESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNV 463
E LGY + C +E++ + +D V L T
Sbjct: 842 PPKELPGELLGYRLQYCRA-------------DEARPNTIDFGKDDQHFTVTGLHKGTTY 888
Query: 464 SLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIF-LNWKEPL--DPNGI 520
++ N G E E I+T ED+P P ++L T L W P+ + NG
Sbjct: 889 IFRLAAKNRAGLGEEFEKEIRTPEDLPSGFP-QNLHVTGLTTSTTELAWDPPVLAERNGR 947
Query: 521 ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580
I Y + + I S Q + N+ T L P TTY +RA T KG G
Sbjct: 948 IISYTVVFRDINS----------QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSG 997
Query: 581 PATAINVTTNISAPTLP 597
P ++ +I + T+P
Sbjct: 998 P-----LSPSIQSRTMP 1009
Score = 50.1 bits (118), Expect = 2e-05
Identities = 66/288 (22%), Positives = 113/288 (39%), Gaps = 21/288 (7%)
Query: 355 PDTEYEIRVL-LTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESL 413
P Y +RVL T G+G P P + +T+ P + P + RI + W L
Sbjct: 480 PGITYSLRVLAFTAVGDGP---PSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLSW--L 533
Query: 414 GYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPE 473
R + + Y+ +E + + DP + + + L P T ++ +
Sbjct: 534 LPPQERIIMYELV----YWAAEDEDQQHKVTFDPTS-SYTLEDLKPDTLYRFQLAARSDM 588
Query: 474 GRKESEETI-IQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYSS 530
G TI +T + P P K + + + ++W P NG+ITQY ++Y +
Sbjct: 589 GVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEA 648
Query: 531 IRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP-ATAINVTT 589
+ D V + W+ + L T Y+ ++RA T G GP ++ + V T
Sbjct: 649 VDGEDRGRHVVDGISREHSSWD-----LVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRT 703
Query: 590 NISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEEL 637
+ P+ P + LN TA + L + I YQ+ L
Sbjct: 704 DEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRL 751
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 499 bits (1286), Expect = e-141
Identities = 300/784 (38%), Positives = 443/784 (56%), Gaps = 75/784 (9%)
Query: 669 YFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRI 728
Y AA+L LPE FT+GD + Y+GF+N PL+P Y + A + K
Sbjct: 1177 YVAAQLDV--LPET--FTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYA--- 1229
Query: 729 ATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAM 788
+ ++E V PA+Q + ++ ++ +L IL++L+VI I+ L K+++
Sbjct: 1230 --SSPYSDEIVVQVTPAQQQEEP-EMLWVTGPVLAVILIILIVIAIL----LFKRKRTHS 1282
Query: 789 GNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVP 848
+++ E + + D H+ DP+ + ++
Sbjct: 1283 PSSKDEQSIGLK-------DSLLAHSSDPVEMRRLN------------------------ 1311
Query: 849 RYLCEGTESPYQTGQL--HPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVA 906
YQT + HP I + DL +I +K +D F +EYES GQ +W+ +
Sbjct: 1312 ----------YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENS 1361
Query: 907 KKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQ 966
+ N+ KNRY N+IAYDHSRVIL ++ P SDYINANYID GY++ + YIATQ
Sbjct: 1362 NLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYID------GYRKQNAYIATQ 1415
Query: 967 GPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEP 1025
GP+ ET+ DFWRM+W++++A +VM+T L E RVKC +YWP TE G +VT ++
Sbjct: 1416 GPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVE 1475
Query: 1026 LAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPI 1085
LA Y VRTF L + G +E RE++QF F WPDHGVP + T +L+F+RRVK NP AGP+
Sbjct: 1476 LATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPM 1535
Query: 1086 VVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAI 1145
VVHCSAG GRTGC+IVID ML+ + E VDIY V +RS+R MVQTE+QY+FIH+A+
Sbjct: 1536 VVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEAL 1595
Query: 1146 LEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLP 1205
LEA CG T +P A + ++ + + ++ EF+ L S + A LP
Sbjct: 1596 LEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLAS--SKAHTSRFISANLP 1653
Query: 1206 RNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKD 1264
N KNR ++++P + L I G E S+YINA+ +D YRQ A+I TQ PL + +D
Sbjct: 1654 CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTED 1713
Query: 1265 FWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIF 1322
FWR+++++ T IVML ++ + C QYWP E RY V+ M+ + ++ I
Sbjct: 1714 FWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYIL 1770
Query: 1323 RICNLTRPQEGY-LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTII 1381
R +T ++G ++QFQ+ W + VP + F+ I QV K +E+ + +G +
Sbjct: 1771 REFKVTDARDGQSRTIRQFQFTDW-PEQGVPKTGEGFIDFIGQVHKTKEQFGQ-DGPITV 1828
Query: 1382 HCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE 1441
HC G GR+G+F + IV+E ++ + VVD+F VKTLR +P MV+ +QY+ CY ALE
Sbjct: 1829 HCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE 1888
Query: 1442 YLES 1445
YL S
Sbjct: 1889 YLGS 1892
Score = 72.0 bits (175), Expect = 4e-12
Identities = 106/447 (23%), Positives = 172/447 (38%), Gaps = 57/447 (12%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWL----QRRNGEDIPVAQTKNINHRRFAASFRLQEV 260
EV G + C+A G + K W+ + +++PV +N+ L V
Sbjct: 242 EVMPGGSVNLTCVAVGAPMPYVK-WMMGAEELTKEDEMPVG--RNV--------LELSNV 290
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
++ Y CV S G + AQ+ V+ P+P P L+ T + L +S +
Sbjct: 291 VRSAN--YTCVAISSLGM-IEATAQVTVKALPKP--PIDLVVTETTATSVTLTWDSGNSE 345
Query: 321 GPIILKEVEYRM--TSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ ++YR T G + E V Y + L P +EY RVL G G P
Sbjct: 346 -PVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV--NSIGRGPPSE 402
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
+ RT P P+ ++ + A + V WE GY + +T + +
Sbjct: 403 AVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV--YYTPDSRRPPN 460
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETI-IQTDEDV 489
+ HN + A L V L P SL+++ G TI ++T + V
Sbjct: 461 AWHKHN-TDAGLLT--------TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGV 511
Query: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
P P + +I L+W P P I YE+ Y + D V P
Sbjct: 512 PAQ-PADFQAEVESDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKVTFDP----- 563
Query: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPAT-AINVTTNISAPTLPDYEGVDASLNE 608
++ + L P T Y+F + A + G G T I T S P+ P + + S+
Sbjct: 564 ---TSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGS 620
Query: 609 TATTITVLLRPAQAKGAPISAYQIVVE 635
T ++ + PA ++ I+ Y + E
Sbjct: 621 TTVRVSWVPPPADSRNGVITQYSVAYE 647
Score = 58.5 bits (140), Expect = 4e-08
Identities = 66/257 (25%), Positives = 96/257 (37%), Gaps = 46/257 (17%)
Query: 353 LDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDW- 410
L P+T Y + V T G+G P I T A P R T+ I+ + W
Sbjct: 778 LTPETTYSVTVAAYTTKGDGARS---KPKIVTTTGAVPGRP--TMMISTTAMNTALLQWH 832
Query: 411 -------ESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNV 463
E LGY + C +E++ + +D V L T
Sbjct: 833 PPKELPGELLGYRLQYCRA-------------DEARPNTIDFGKDDQHFTVTGLHKGTTY 879
Query: 464 SLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIF-LNWKEPL--DPNGI 520
++ N G E E I+T ED+P P ++L T L W P+ + NG
Sbjct: 880 IFRLAAKNRAGLGEEFEKEIRTPEDLPSGFP-QNLHVTGLTTSTTELAWDPPVLAERNGR 938
Query: 521 ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580
I Y + + I S Q + N+ T L P TTY +RA T KG G
Sbjct: 939 IISYTVVFRDINS----------QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSG 988
Query: 581 PATAINVTTNISAPTLP 597
P ++ +I + T+P
Sbjct: 989 P-----LSPSIQSRTMP 1000
Score = 50.1 bits (118), Expect = 2e-05
Identities = 66/288 (22%), Positives = 113/288 (39%), Gaps = 21/288 (7%)
Query: 355 PDTEYEIRVL-LTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESL 413
P Y +RVL T G+G P P + +T+ P + P + RI + W L
Sbjct: 480 PGITYSLRVLAFTAVGDGP---PSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLSW--L 533
Query: 414 GYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPE 473
R + + Y+ +E + + DP + + + L P T ++ +
Sbjct: 534 LPPQERIIMYELV----YWAAEDEDQQHKVTFDPTS-SYTLEDLKPDTLYRFQLAARSDM 588
Query: 474 GRKESEETI-IQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYSS 530
G TI +T + P P K + + + ++W P NG+ITQY ++Y +
Sbjct: 589 GVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEA 648
Query: 531 IRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP-ATAINVTT 589
+ D V + W+ + L T Y+ ++RA T G GP ++ + V T
Sbjct: 649 VDGEDRGRHVVDGISREHSSWD-----LVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRT 703
Query: 590 NISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEEL 637
+ P+ P + LN TA + L + I YQ+ L
Sbjct: 704 DEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRL 751
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 435 bits (1118), Expect = e-121
Identities = 236/594 (39%), Positives = 356/594 (59%), Gaps = 22/594 (3%)
Query: 861 TGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGN 919
T + +P + V L + IN D+ F+EE+ + A+ + A K++N+ KNRY N
Sbjct: 205 TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 264
Query: 920 IIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRM 979
I+ YDHSRV L PVE P SDYINA++I+ GYQ + +IA QGP ETV DFWRM
Sbjct: 265 ILPYDHSRVHLTPVEGVPDSDYINASFIN------GYQEKNKFIAAQGPKEETVNDFWRM 318
Query: 980 IWQEQSACIVMVTNLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLER 1038
IW++ +A IVMVTNL E KC +YWPD YG+ +V+ ++ L +Y VR F +++
Sbjct: 319 IWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQ 378
Query: 1039 RGYNEIRE----VKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAG 1094
G R+ + QFHFT WPD GVP+ G+L F+++VK NP AG IVVHCSAG G
Sbjct: 379 VGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVG 438
Query: 1095 RTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGET 1154
RTG ++VID MLDM E VD+Y V +R++R MVQT+ QY+FI+ A+LE L G+T
Sbjct: 439 RTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDT 498
Query: 1155 AIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFM 1214
+ V + + T+++ L++EF+ L S+ ++Q + LP N KNR +
Sbjct: 499 ELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVL 556
Query: 1215 DMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYG 1273
++P + + G E+++Y+NA+ +D YRQ ++I +Q PL +T++DFWR+++++
Sbjct: 557 QIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWK 616
Query: 1274 CTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQ 1331
SIVML E++ + C QYWP +G++ YG I VE + +C+ + TR
Sbjct: 617 SCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVE-LKKEEECESYTVRDLLVTNTREN 675
Query: 1332 EGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSG 1391
+ ++QF + GW +P + + +I V+K Q+ + G +HC G GR+G
Sbjct: 676 KS-RQIRQFHFHGW-PEVGIPSDGKGMISIIAAVQKQQQ--QSGNHPITVHCSAGAGRTG 731
Query: 1392 MFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445
FCA+ V+E VK + ++DVF VK+LR +P+MV+ EQY FCY V EY+++
Sbjct: 732 TFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA 785
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 435 bits (1118), Expect = e-121
Identities = 236/594 (39%), Positives = 356/594 (59%), Gaps = 22/594 (3%)
Query: 861 TGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGN 919
T + +P + V L + IN D+ F+EE+ + A+ + A K++N+ KNRY N
Sbjct: 214 TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 273
Query: 920 IIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRM 979
I+ YDHSRV L PVE P SDYINA++I+ GYQ + +IA QGP ETV DFWRM
Sbjct: 274 ILPYDHSRVHLTPVEGVPDSDYINASFIN------GYQEKNKFIAAQGPKEETVNDFWRM 327
Query: 980 IWQEQSACIVMVTNLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLER 1038
IW++ +A IVMVTNL E KC +YWPD YG+ +V+ ++ L +Y VR F +++
Sbjct: 328 IWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQ 387
Query: 1039 RGYNEIRE----VKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAG 1094
G R+ + QFHFT WPD GVP+ G+L F+++VK NP AG IVVHCSAG G
Sbjct: 388 VGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVG 447
Query: 1095 RTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGET 1154
RTG ++VID MLDM E VD+Y V +R++R MVQT+ QY+FI+ A+LE L G+T
Sbjct: 448 RTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDT 507
Query: 1155 AIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFM 1214
+ V + + T+++ L++EF+ L S+ ++Q + LP N KNR +
Sbjct: 508 ELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVL 565
Query: 1215 DMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYG 1273
++P + + G E+++Y+NA+ +D YRQ ++I +Q PL +T++DFWR+++++
Sbjct: 566 QIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWK 625
Query: 1274 CTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQ 1331
SIVML E++ + C QYWP +G++ YG I VE + +C+ + TR
Sbjct: 626 SCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVE-LKKEEECESYTVRDLLVTNTREN 684
Query: 1332 EGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSG 1391
+ ++QF + GW +P + + +I V+K Q+ + G +HC G GR+G
Sbjct: 685 KS-RQIRQFHFHGW-PEVGIPSDGKGMISIIAAVQKQQQ--QSGNHPITVHCSAGAGRTG 740
Query: 1392 MFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445
FCA+ V+E VK + ++DVF VK+LR +P+MV+ EQY FCY V EY+++
Sbjct: 741 TFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA 794
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 435 bits (1118), Expect = e-121
Identities = 236/594 (39%), Positives = 356/594 (59%), Gaps = 22/594 (3%)
Query: 861 TGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGN 919
T + +P + V L + IN D+ F+EE+ + A+ + A K++N+ KNRY N
Sbjct: 205 TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 264
Query: 920 IIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRM 979
I+ YDHSRV L PVE P SDYINA++I+ GYQ + +IA QGP ETV DFWRM
Sbjct: 265 ILPYDHSRVHLTPVEGVPDSDYINASFIN------GYQEKNKFIAAQGPKEETVNDFWRM 318
Query: 980 IWQEQSACIVMVTNLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLER 1038
IW++ +A IVMVTNL E KC +YWPD YG+ +V+ ++ L +Y VR F +++
Sbjct: 319 IWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQ 378
Query: 1039 RGYNEIRE----VKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAG 1094
G R+ + QFHFT WPD GVP+ G+L F+++VK NP AG IVVHCSAG G
Sbjct: 379 VGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVG 438
Query: 1095 RTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGET 1154
RTG ++VID MLDM E VD+Y V +R++R MVQT+ QY+FI+ A+LE L G+T
Sbjct: 439 RTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDT 498
Query: 1155 AIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFM 1214
+ V + + T+++ L++EF+ L S+ ++Q + LP N KNR +
Sbjct: 499 ELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVL 556
Query: 1215 DMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYG 1273
++P + + G E+++Y+NA+ +D YRQ ++I +Q PL +T++DFWR+++++
Sbjct: 557 QIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWK 616
Query: 1274 CTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQ 1331
SIVML E++ + C QYWP +G++ YG I VE + +C+ + TR
Sbjct: 617 SCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVE-LKKEEECESYTVRDLLVTNTREN 675
Query: 1332 EGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSG 1391
+ ++QF + GW +P + + +I V+K Q+ + G +HC G GR+G
Sbjct: 676 KS-RQIRQFHFHGW-PEVGIPSDGKGMISIIAAVQKQQQ--QSGNHPITVHCSAGAGRTG 731
Query: 1392 MFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445
FCA+ V+E VK + ++DVF VK+LR +P+MV+ EQY FCY V EY+++
Sbjct: 732 TFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA 785
>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
precursor [Homo sapiens]
Length = 700
Score = 420 bits (1079), Expect = e-117
Identities = 238/589 (40%), Positives = 346/589 (58%), Gaps = 24/589 (4%)
Query: 868 IRVADLLQHINLMKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGNIIAYDHS 926
I V L + I + D F+EE+ S G ++++A K++NR KNRY NI+ DHS
Sbjct: 115 IPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHS 174
Query: 927 RVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSA 986
RVIL ++ P SDYINA+YID GY+ + +IA QGP ETV DFWRM+W+++SA
Sbjct: 175 RVILSQLDGIPCSDYINASYID------GYKEKNKFIAAQGPKQETVNDFWRMVWEQKSA 228
Query: 987 CIVMVTNLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLERR---GYN 1042
IVM+TNL E KC++YWPD YG+ +V + L +Y +R F ++ + G
Sbjct: 229 TIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCK 288
Query: 1043 EIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVI 1102
R V Q HFT WPD GVP+ G+L F+++VK NP AGPIVVHCSAG GRTG +IVI
Sbjct: 289 APRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVI 348
Query: 1103 DIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFK 1162
D M+ M E VD++ V +R++R MVQT+ QY FI+ A+LE L G+T + V +
Sbjct: 349 DAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLE 408
Query: 1163 AAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRC 1222
M + + L++EF+ L +V R+ E+ LP N K R + ++P D
Sbjct: 409 KHLQTMHGTTTHFDKIGLEEEFRKLTNV--RIMKENMRTGNLPANMKKARVIQIIPYDFN 466
Query: 1223 LPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLN 1281
L G E ++YINA+ +D YRQ FI TQ PL +TV+DFWR+++++ +IVML
Sbjct: 467 RVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLT 526
Query: 1282 EVDLSQ--GCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQ----EGYL 1335
EV + C QYWP EG + +G I +E + ++ + R F + L +PQ E
Sbjct: 527 EVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDF-LVTLNQPQARQEEQVR 585
Query: 1336 MVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCA 1395
+V+QF + GW +P + + LI V+K Q+ + G +HC G GR+G F A
Sbjct: 586 VVRQFHFHGW-PEIGIPAEGKGMIDLIAAVQKQQQ--QTGNHPITVHCSAGAGRTGTFIA 642
Query: 1396 IGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1444
+ ++E VK + ++DVF AVK+LR +P+MV+ EQY FCY V ++++
Sbjct: 643 LSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID 691
>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
[Homo sapiens]
Length = 642
Score = 420 bits (1079), Expect = e-117
Identities = 238/589 (40%), Positives = 346/589 (58%), Gaps = 24/589 (4%)
Query: 868 IRVADLLQHINLMKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGNIIAYDHS 926
I V L + I + D F+EE+ S G ++++A K++NR KNRY NI+ DHS
Sbjct: 57 IPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHS 116
Query: 927 RVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSA 986
RVIL ++ P SDYINA+YID GY+ + +IA QGP ETV DFWRM+W+++SA
Sbjct: 117 RVILSQLDGIPCSDYINASYID------GYKEKNKFIAAQGPKQETVNDFWRMVWEQKSA 170
Query: 987 CIVMVTNLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLERR---GYN 1042
IVM+TNL E KC++YWPD YG+ +V + L +Y +R F ++ + G
Sbjct: 171 TIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCK 230
Query: 1043 EIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVI 1102
R V Q HFT WPD GVP+ G+L F+++VK NP AGPIVVHCSAG GRTG +IVI
Sbjct: 231 APRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVI 290
Query: 1103 DIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFK 1162
D M+ M E VD++ V +R++R MVQT+ QY FI+ A+LE L G+T + V +
Sbjct: 291 DAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLE 350
Query: 1163 AAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRC 1222
M + + L++EF+ L +V R+ E+ LP N K R + ++P D
Sbjct: 351 KHLQTMHGTTTHFDKIGLEEEFRKLTNV--RIMKENMRTGNLPANMKKARVIQIIPYDFN 408
Query: 1223 LPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLN 1281
L G E ++YINA+ +D YRQ FI TQ PL +TV+DFWR+++++ +IVML
Sbjct: 409 RVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLT 468
Query: 1282 EVDLSQ--GCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQ----EGYL 1335
EV + C QYWP EG + +G I +E + ++ + R F + L +PQ E
Sbjct: 469 EVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDF-LVTLNQPQARQEEQVR 527
Query: 1336 MVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCA 1395
+V+QF + GW +P + + LI V+K Q+ + G +HC G GR+G F A
Sbjct: 528 VVRQFHFHGW-PEIGIPAEGKGMIDLIAAVQKQQQ--QTGNHPITVHCSAGAGRTGTFIA 584
Query: 1396 IGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1444
+ ++E VK + ++DVF AVK+LR +P+MV+ EQY FCY V ++++
Sbjct: 585 LSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID 633
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 369 bits (947), Expect = e-101
Identities = 220/587 (37%), Positives = 330/587 (56%), Gaps = 41/587 (6%)
Query: 885 SYGFKEEYES----FFEGQSASWDV------AKKDQNRAKNRYGNIIAYDHSRVILQPV- 933
S GF EE+E+ + E QS + D+ + N+ KNRY NI+AYDHSRV L +
Sbjct: 1714 SSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLA 1773
Query: 934 -EDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVT 992
+D +DYINANY+D GY RP YIA QGP+ T DFWRMIW+ IVM+T
Sbjct: 1774 EKDGKLTDYINANYVD------GYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMIT 1827
Query: 993 NLVEVGRVKCYKYWP-DDTEVYGDFKVTCVEMEPLAEYVVRTFTLE--------RRGYNE 1043
NLVE GR KC +YWP D +E YG+F VT ++ LA Y VR FTL ++G
Sbjct: 1828 NLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPS 1887
Query: 1044 IREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVID 1103
R V Q+H+T WPD GVP ++ +L+F+R+ + + GP+VVHCSAG GRTG YIV+D
Sbjct: 1888 GRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLD 1947
Query: 1104 IMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKA 1163
ML + EG V+I+ +K +RS+R +VQTEEQY+FIHD ++EA L ET + +
Sbjct: 1948 SMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV-LDSHIH 2006
Query: 1164 AYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCL 1223
AY + + I + L+ +FQ L+ +Q D S A N +KNR ++P +R
Sbjct: 2007 AYVNALLIPGPAGKTKLEKQFQLLSQ--SNIQQSDYSAALKQCNREKNRTSSIIPVERSR 2064
Query: 1224 PFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNE- 1282
+ ++ GE ++YINA+ + Y Q FI+TQ+PL +T+KDFWR+++D+ +VM+ +
Sbjct: 2065 VGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDG 2124
Query: 1283 VDLSQGCPQYWP-EEGMLRYGPIQVECMSCSMDC--DVINRIFRICNLTRPQEGYLM-VQ 1338
++++ YWP ++ + +V M+ C + I + L Q+ Y++ V+
Sbjct: 2125 QNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVR 2184
Query: 1339 QFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGI 1398
FQ W P K + +EE +G I+H +GG +G FCA+
Sbjct: 2185 HFQCPKW------PNPDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTT 2238
Query: 1399 VVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445
++ ++++N VDV+ K + +P + EQY+F Y V L + +
Sbjct: 2239 LMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST 2285
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 354 bits (908), Expect = 4e-97
Identities = 220/614 (35%), Positives = 332/614 (54%), Gaps = 62/614 (10%)
Query: 867 AIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDV------AKKDQNRAKNRYGNI 920
AI V ++HI + +++ +GF E++E E Q + D+ + +N+ KNRY NI
Sbjct: 827 AIPVKQFVKHIGELYSNNQHGFSEDFE---EVQRCTADMNITAEHSNHPENKHKNRYINI 883
Query: 921 IAYDHSRVILQPV--EDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWR 978
+AYDHSRV L+P+ +D SDYINANY+D GY + YIATQGP+ T DFWR
Sbjct: 884 LAYDHSRVKLRPLPGKDSKHSDYINANYVD------GYNKAKAYIATQGPLKSTFEDFWR 937
Query: 979 MIWQEQSACIVMVTNLVEVGRVKCYKYWP-DDTEVYGDFKVTCVEMEPLAEYVVRTFTLE 1037
MIW++ + IVM+TNLVE GR KC +YWP +++E YG+ VT + A Y VR F++
Sbjct: 938 MIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIR 997
Query: 1038 R-----------RGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIV 1086
+G R V Q+H+T WPD GVP +A +L+F+RR + P GP++
Sbjct: 998 NTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVL 1057
Query: 1087 VHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAIL 1146
VHCSAG GRTG YIVID ML + + V++ +K +R++R +VQTEEQYIFIHDA+L
Sbjct: 1058 VHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALL 1117
Query: 1147 EACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPR 1206
EA L ET + + +Y + I I + L+ +F+ + + +C A
Sbjct: 1118 EAILGKETEVSSNQLH-SYVNSILIPGVGGKTRLEKQFKLVTQCNAKY--VECFSAQKEC 1174
Query: 1207 NHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDF 1265
N +KNR ++P +R L + G + ++YINA+ + Y + FI+TQ+PLP+T KDF
Sbjct: 1175 NKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDF 1234
Query: 1266 WRLVYDYGCTSIVML-NEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRI 1324
WR+++D+ IVML + L++ YWP + E M+C + R+
Sbjct: 1235 WRMIWDHNAQIIVMLPDNQSLAEDEFVYWPS---------REESMNCEAFTVTLISKDRL 1285
Query: 1325 C------------NLTRPQEGYLM-VQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEE 1371
C L Q+ Y++ V+ FQ W + S + +I +EE
Sbjct: 1286 CLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISSTFELINVI------KEE 1339
Query: 1372 CEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQ 1431
+G TI+H G +GM CA+ + + ++ +N VDVF K + +P + EQ
Sbjct: 1340 ALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQ 1399
Query: 1432 YRFCYDVALEYLES 1445
Y+F Y L + +
Sbjct: 1400 YQFIYKAMLSLVST 1413
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
precursor [Homo sapiens]
Length = 1256
Score = 330 bits (847), Expect = 5e-90
Identities = 210/567 (37%), Positives = 293/567 (51%), Gaps = 48/567 (8%)
Query: 906 AKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIAT 965
A+K N+ KNRY +I+ YD++RV L + D S+YINA+YID G++ P YIA
Sbjct: 622 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYID------GFKEPRKYIAA 675
Query: 966 QGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP---DDTEVYGDFKVTCVE 1022
QGP ETV DFWRMIW++++ IVMVT E R KC +YWP + T +GD V +
Sbjct: 676 QGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQ 735
Query: 1023 MEPLAEYVVRTFTLERRGYNEI-REVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPS 1081
+ +Y+++ + + REV FT WPDHGVP LL RRV +
Sbjct: 736 HKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFF 795
Query: 1082 AGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFI 1141
+GPIVVHCSAG GRTG YI ID ML+ E E VD+Y V LR +R MVQ E QYI I
Sbjct: 796 SGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILI 855
Query: 1142 HDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTP-RLQAEDCS 1200
H A++E GET + + E +M + D + S L+ EFQ L S R Q
Sbjct: 856 HQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ----H 911
Query: 1201 IACLPRNHDKNRFMDMLPPD-RCLPFLITID-------------------GESSNYINAA 1240
I N KNR +++P D +P ++ E S YINA+
Sbjct: 912 IGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINAS 971
Query: 1241 LMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGM 1298
+ SY +P I Q PL T+ DFW++++ IVML E+ + C QYW EG
Sbjct: 972 FIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGK 1030
Query: 1299 LRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSF 1358
YG I+V+ R+F + + R V Q+QY W S ++P +
Sbjct: 1031 QTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKEL 1087
Query: 1359 LKLILQVEKWQEECEEGEGR-------TIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDV 1411
+ +I V++ + EG +IHC +G ++G+FCA+ ++E + + VVD+
Sbjct: 1088 ISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDI 1147
Query: 1412 FHAVKTLRNSKPNMVEAPEQYRFCYDV 1438
F VK LR ++P MV EQY+F YDV
Sbjct: 1148 FQVVKALRKARPGMVSTFEQYQFLYDV 1174
Score = 156 bits (395), Expect = 1e-37
Identities = 100/312 (32%), Positives = 158/312 (50%), Gaps = 40/312 (12%)
Query: 868 IRVADLLQHINLMKTSDSYGFKEEYESFFEGQSA--SW---DVAKKDQNRAKNRYGNIIA 922
+ +++L +++ MK D E+ F+ + SW + +++N++KNR N+I
Sbjct: 870 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 929
Query: 923 YDHSRVILQPV---------EDDPSSD----------YINANYIDIWLYRDGYQRPSHYI 963
YD++RV L+ + D SSD YINA++I Y +P I
Sbjct: 930 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM------SYWKPEVMI 983
Query: 964 ATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEM 1023
A QGP+ ET+ DFW+MI+Q + IVM+T L + C +YW + + YGD +V +
Sbjct: 984 AAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDT 1043
Query: 1024 EPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPS-- 1081
+ + Y +R F L + R V Q+ +T W +P L+S I+ VK P
Sbjct: 1044 DKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNS 1103
Query: 1082 --------AGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQ 1133
+ P+++HC G+ +TG + + +L+ AE E VVDI+ VKALR R MV
Sbjct: 1104 SEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVS 1163
Query: 1134 TEEQYIFIHDAI 1145
T EQY F++D I
Sbjct: 1164 TFEQYQFLYDVI 1175
Score = 122 bits (306), Expect = 2e-27
Identities = 84/265 (31%), Positives = 130/265 (49%), Gaps = 13/265 (4%)
Query: 1183 EFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGES-SNYINAAL 1241
EFQ++ V + ++ A P N +KNR++D+LP D L I+G++ SNYINA+
Sbjct: 606 EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 662
Query: 1242 MDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQG--CPQYWP--EEG 1297
+D +++P +I Q P TV DFWR++++ T IVM+ + C +YWP EEG
Sbjct: 663 IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 722
Query: 1298 MLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRS 1357
+G + V+ D I + I N G V Q+ W H VP
Sbjct: 723 TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGR-EVTHIQFTSWPDHG-VPEDPHL 780
Query: 1358 FLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKT 1417
LKL +V + G ++HC G GR+G + I ++E ++ +N VDV+ V
Sbjct: 781 LLKLRRRVNAFSNFFS---GPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 837
Query: 1418 LRNSKPNMVEAPEQYRFCYDVALEY 1442
LR + MV+ QY + +EY
Sbjct: 838 LRRQRCLMVQVEAQYILIHQALVEY 862
Score = 33.9 bits (76), Expect = 1.2
Identities = 26/106 (24%), Positives = 47/106 (44%), Gaps = 9/106 (8%)
Query: 424 NVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKM---ILTNPEGRKESEE 480
N T+CY E++ DCL++D ++ + +L PYT L + I+ + +
Sbjct: 371 NFTLCYI-----KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAM 425
Query: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEI 526
T P V ++ TS +N + + + P D NG +Y +
Sbjct: 426 CHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDRNGPHERYHL 470
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
precursor [Homo sapiens]
Length = 1304
Score = 330 bits (847), Expect = 5e-90
Identities = 210/567 (37%), Positives = 293/567 (51%), Gaps = 48/567 (8%)
Query: 906 AKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIAT 965
A+K N+ KNRY +I+ YD++RV L + D S+YINA+YID G++ P YIA
Sbjct: 670 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYID------GFKEPRKYIAA 723
Query: 966 QGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP---DDTEVYGDFKVTCVE 1022
QGP ETV DFWRMIW++++ IVMVT E R KC +YWP + T +GD V +
Sbjct: 724 QGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQ 783
Query: 1023 MEPLAEYVVRTFTLERRGYNEI-REVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPS 1081
+ +Y+++ + + REV FT WPDHGVP LL RRV +
Sbjct: 784 HKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFF 843
Query: 1082 AGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFI 1141
+GPIVVHCSAG GRTG YI ID ML+ E E VD+Y V LR +R MVQ E QYI I
Sbjct: 844 SGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILI 903
Query: 1142 HDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTP-RLQAEDCS 1200
H A++E GET + + E +M + D + S L+ EFQ L S R Q
Sbjct: 904 HQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ----H 959
Query: 1201 IACLPRNHDKNRFMDMLPPD-RCLPFLITID-------------------GESSNYINAA 1240
I N KNR +++P D +P ++ E S YINA+
Sbjct: 960 IGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINAS 1019
Query: 1241 LMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGM 1298
+ SY +P I Q PL T+ DFW++++ IVML E+ + C QYW EG
Sbjct: 1020 FIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGK 1078
Query: 1299 LRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSF 1358
YG I+V+ R+F + + R V Q+QY W S ++P +
Sbjct: 1079 QTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKEL 1135
Query: 1359 LKLILQVEKWQEECEEGEGR-------TIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDV 1411
+ +I V++ + EG +IHC +G ++G+FCA+ ++E + + VVD+
Sbjct: 1136 ISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDI 1195
Query: 1412 FHAVKTLRNSKPNMVEAPEQYRFCYDV 1438
F VK LR ++P MV EQY+F YDV
Sbjct: 1196 FQVVKALRKARPGMVSTFEQYQFLYDV 1222
Score = 156 bits (395), Expect = 1e-37
Identities = 100/312 (32%), Positives = 158/312 (50%), Gaps = 40/312 (12%)
Query: 868 IRVADLLQHINLMKTSDSYGFKEEYESFFEGQSA--SW---DVAKKDQNRAKNRYGNIIA 922
+ +++L +++ MK D E+ F+ + SW + +++N++KNR N+I
Sbjct: 918 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 977
Query: 923 YDHSRVILQPV---------EDDPSSD----------YINANYIDIWLYRDGYQRPSHYI 963
YD++RV L+ + D SSD YINA++I Y +P I
Sbjct: 978 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM------SYWKPEVMI 1031
Query: 964 ATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEM 1023
A QGP+ ET+ DFW+MI+Q + IVM+T L + C +YW + + YGD +V +
Sbjct: 1032 AAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDT 1091
Query: 1024 EPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPS-- 1081
+ + Y +R F L + R V Q+ +T W +P L+S I+ VK P
Sbjct: 1092 DKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNS 1151
Query: 1082 --------AGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQ 1133
+ P+++HC G+ +TG + + +L+ AE E VVDI+ VKALR R MV
Sbjct: 1152 SEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVS 1211
Query: 1134 TEEQYIFIHDAI 1145
T EQY F++D I
Sbjct: 1212 TFEQYQFLYDVI 1223
Score = 122 bits (306), Expect = 2e-27
Identities = 84/265 (31%), Positives = 130/265 (49%), Gaps = 13/265 (4%)
Query: 1183 EFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGES-SNYINAAL 1241
EFQ++ V + ++ A P N +KNR++D+LP D L I+G++ SNYINA+
Sbjct: 654 EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 710
Query: 1242 MDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQG--CPQYWP--EEG 1297
+D +++P +I Q P TV DFWR++++ T IVM+ + C +YWP EEG
Sbjct: 711 IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 770
Query: 1298 MLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRS 1357
+G + V+ D I + I N G V Q+ W H VP
Sbjct: 771 TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGR-EVTHIQFTSWPDHG-VPEDPHL 828
Query: 1358 FLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKT 1417
LKL +V + G ++HC G GR+G + I ++E ++ +N VDV+ V
Sbjct: 829 LLKLRRRVNAFSNFFS---GPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 885
Query: 1418 LRNSKPNMVEAPEQYRFCYDVALEY 1442
LR + MV+ QY + +EY
Sbjct: 886 LRRQRCLMVQVEAQYILIHQALVEY 910
Score = 33.9 bits (76), Expect = 1.2
Identities = 26/106 (24%), Positives = 47/106 (44%), Gaps = 9/106 (8%)
Query: 424 NVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKM---ILTNPEGRKESEE 480
N T+CY E++ DCL++D ++ + +L PYT L + I+ + +
Sbjct: 419 NFTLCYI-----KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAM 473
Query: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEI 526
T P V ++ TS +N + + + P D NG +Y +
Sbjct: 474 CHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDRNGPHERYHL 518
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
precursor [Homo sapiens]
Length = 1143
Score = 330 bits (847), Expect = 5e-90
Identities = 210/567 (37%), Positives = 293/567 (51%), Gaps = 48/567 (8%)
Query: 906 AKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIAT 965
A+K N+ KNRY +I+ YD++RV L + D S+YINA+YID G++ P YIA
Sbjct: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYID------GFKEPRKYIAA 562
Query: 966 QGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP---DDTEVYGDFKVTCVE 1022
QGP ETV DFWRMIW++++ IVMVT E R KC +YWP + T +GD V +
Sbjct: 563 QGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQ 622
Query: 1023 MEPLAEYVVRTFTLERRGYNEI-REVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPS 1081
+ +Y+++ + + REV FT WPDHGVP LL RRV +
Sbjct: 623 HKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFF 682
Query: 1082 AGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFI 1141
+GPIVVHCSAG GRTG YI ID ML+ E E VD+Y V LR +R MVQ E QYI I
Sbjct: 683 SGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILI 742
Query: 1142 HDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTP-RLQAEDCS 1200
H A++E GET + + E +M + D + S L+ EFQ L S R Q
Sbjct: 743 HQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ----H 798
Query: 1201 IACLPRNHDKNRFMDMLPPD-RCLPFLITID-------------------GESSNYINAA 1240
I N KNR +++P D +P ++ E S YINA+
Sbjct: 799 IGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINAS 858
Query: 1241 LMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGM 1298
+ SY +P I Q PL T+ DFW++++ IVML E+ + C QYW EG
Sbjct: 859 FIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGK 917
Query: 1299 LRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSF 1358
YG I+V+ R+F + + R V Q+QY W S ++P +
Sbjct: 918 QTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKEL 974
Query: 1359 LKLILQVEKWQEECEEGEGR-------TIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDV 1411
+ +I V++ + EG +IHC +G ++G+FCA+ ++E + + VVD+
Sbjct: 975 ISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDI 1034
Query: 1412 FHAVKTLRNSKPNMVEAPEQYRFCYDV 1438
F VK LR ++P MV EQY+F YDV
Sbjct: 1035 FQVVKALRKARPGMVSTFEQYQFLYDV 1061
Score = 156 bits (395), Expect = 1e-37
Identities = 100/312 (32%), Positives = 158/312 (50%), Gaps = 40/312 (12%)
Query: 868 IRVADLLQHINLMKTSDSYGFKEEYESFFEGQSA--SW---DVAKKDQNRAKNRYGNIIA 922
+ +++L +++ MK D E+ F+ + SW + +++N++KNR N+I
Sbjct: 757 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 816
Query: 923 YDHSRVILQPV---------EDDPSSD----------YINANYIDIWLYRDGYQRPSHYI 963
YD++RV L+ + D SSD YINA++I Y +P I
Sbjct: 817 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM------SYWKPEVMI 870
Query: 964 ATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEM 1023
A QGP+ ET+ DFW+MI+Q + IVM+T L + C +YW + + YGD +V +
Sbjct: 871 AAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDT 930
Query: 1024 EPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPS-- 1081
+ + Y +R F L + R V Q+ +T W +P L+S I+ VK P
Sbjct: 931 DKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNS 990
Query: 1082 --------AGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQ 1133
+ P+++HC G+ +TG + + +L+ AE E VVDI+ VKALR R MV
Sbjct: 991 SEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVS 1050
Query: 1134 TEEQYIFIHDAI 1145
T EQY F++D I
Sbjct: 1051 TFEQYQFLYDVI 1062
Score = 122 bits (306), Expect = 2e-27
Identities = 84/265 (31%), Positives = 130/265 (49%), Gaps = 13/265 (4%)
Query: 1183 EFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGES-SNYINAAL 1241
EFQ++ V + ++ A P N +KNR++D+LP D L I+G++ SNYINA+
Sbjct: 493 EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 549
Query: 1242 MDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQG--CPQYWP--EEG 1297
+D +++P +I Q P TV DFWR++++ T IVM+ + C +YWP EEG
Sbjct: 550 IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 609
Query: 1298 MLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRS 1357
+G + V+ D I + I N G V Q+ W H VP
Sbjct: 610 TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGR-EVTHIQFTSWPDHG-VPEDPHL 667
Query: 1358 FLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKT 1417
LKL +V + G ++HC G GR+G + I ++E ++ +N VDV+ V
Sbjct: 668 LLKLRRRVNAFSNFFS---GPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 724
Query: 1418 LRNSKPNMVEAPEQYRFCYDVALEY 1442
LR + MV+ QY + +EY
Sbjct: 725 LRRQRCLMVQVEAQYILIHQALVEY 749
Score = 33.9 bits (76), Expect = 1.2
Identities = 26/106 (24%), Positives = 47/106 (44%), Gaps = 9/106 (8%)
Query: 424 NVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKM---ILTNPEGRKESEE 480
N T+CY E++ DCL++D ++ + +L PYT L + I+ + +
Sbjct: 258 NFTLCYI-----KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAM 312
Query: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEI 526
T P V ++ TS +N + + + P D NG +Y +
Sbjct: 313 CHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDRNGPHERYHL 357
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,794,595
Number of Sequences: 37866
Number of extensions: 2969400
Number of successful extensions: 8972
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 134
Number of HSP's successfully gapped in prelim test: 137
Number of HSP's that attempted gapping in prelim test: 7069
Number of HSP's gapped (non-prelim): 1139
length of query: 1446
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1331
effective length of database: 13,892,928
effective search space: 18491487168
effective search space used: 18491487168
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.