Search of human proteins with 19923279

Search of human proteins with 19923279

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19923279 semaphorin W [Homo sapiens]
         (770 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19923279 semaphorin W [Homo sapiens]                              1576   0.0  
gi|157388902 semaphorin 4C [Homo sapiens]                             408   e-113
gi|39777610 semaphorin 4B precursor [Homo sapiens]                    391   e-108
gi|39777608 semaphorin 4B precursor [Homo sapiens]                    391   e-108
gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]                   387   e-107
gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]                   379   e-105
gi|28872814 semaphorin 4G [Homo sapiens]                              360   4e-99
gi|21361914 semaphorin B [Homo sapiens]                               337   2e-92
gi|41406086 semaphorin 3D [Homo sapiens]                              296   4e-80
gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]           295   1e-79
gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]          293   4e-79
gi|9910362 semaphorin sem2 [Homo sapiens]                             276   5e-74
gi|5174673 semaphorin 3A precursor [Homo sapiens]                     270   4e-72
gi|6912650 semaphorin 3E [Homo sapiens]                               259   9e-69
gi|5454048 semaphorin 3C [Homo sapiens]                               253   5e-67
gi|188497703 semaphorin 3F [Homo sapiens]                             252   8e-67
gi|19718780 semaphorin 6B precursor [Homo sapiens]                    234   3e-61
gi|11991660 sema domain, transmembrane domain (TM), and cytoplas...   231   3e-60
gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]          224   3e-58
gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]          224   3e-58
gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]          224   3e-58
gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]          224   3e-58
gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]          224   3e-58
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]                    216   5e-56
gi|16306552 semaphorin Y [Homo sapiens]                               214   2e-55
gi|147904700 semaphorin 5A [Homo sapiens]                             212   1e-54
gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]          210   4e-54
gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]       180   5e-45
gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens]     180   5e-45
gi|225637524 semaphorin 7A isoform 3 [Homo sapiens]                   157   3e-38

>gi|19923279 semaphorin W [Homo sapiens]
          Length = 770

 Score = 1576 bits (4080), Expect = 0.0
 Identities = 770/770 (100%), Positives = 770/770 (100%)

Query: 1   MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVP 60
           MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVP
Sbjct: 1   MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVP 60

Query: 61  HTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKED 120
           HTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKED
Sbjct: 61  HTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKED 120

Query: 121 ECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAA 180
           ECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAA
Sbjct: 121 ECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAA 180

Query: 181 VMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGD 240
           VMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGD
Sbjct: 181 VMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGD 240

Query: 241 EDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGP 300
           EDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGP
Sbjct: 241 EDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGP 300

Query: 301 EHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRE 360
           EHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRE
Sbjct: 301 EHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRE 360

Query: 361 LKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFP 420
           LKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFP
Sbjct: 361 LKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFP 420

Query: 421 ADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLAL 480
           ADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLAL
Sbjct: 421 ADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLAL 480

Query: 481 FPEPQPVENMKLYHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECV 540
           FPEPQPVENMKLYHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECV
Sbjct: 481 FPEPQPVENMKLYHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECV 540

Query: 541 AHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPVATAAHVVLPCSPSSAWASCVWHQ 600
           AHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPVATAAHVVLPCSPSSAWASCVWHQ
Sbjct: 541 AHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPVATAAHVVLPCSPSSAWASCVWHQ 600

Query: 601 PSGVTALTPRRDGLEVVVTPGAMGAYACECQEGGAAHVVAAYSLVWGSQRDAPSRAHTVG 660
           PSGVTALTPRRDGLEVVVTPGAMGAYACECQEGGAAHVVAAYSLVWGSQRDAPSRAHTVG
Sbjct: 601 PSGVTALTPRRDGLEVVVTPGAMGAYACECQEGGAAHVVAAYSLVWGSQRDAPSRAHTVG 660

Query: 661 AGLAGFFLGILAASLTLILIGRRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPS 720
           AGLAGFFLGILAASLTLILIGRRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPS
Sbjct: 661 AGLAGFFLGILAASLTLILIGRRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPS 720

Query: 721 PEDERLPLALAKRGSGFGGFSPPFLLDPCPSPAHIRLTGAPLATCDETSI 770
           PEDERLPLALAKRGSGFGGFSPPFLLDPCPSPAHIRLTGAPLATCDETSI
Sbjct: 721 PEDERLPLALAKRGSGFGGFSPPFLLDPCPSPAHIRLTGAPLATCDETSI 770


>gi|157388902 semaphorin 4C [Homo sapiens]
          Length = 833

 Score =  408 bits (1048), Expect = e-113
 Identities = 274/761 (36%), Positives = 392/761 (51%), Gaps = 49/761 (6%)

Query: 40  VPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRR 99
           VPR ++   E  + + RF+     ++  L +   +  LYVGAR+ +FA S+  + E    
Sbjct: 28  VPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSME-ALELQGA 86

Query: 100 IDWMVPEAHRQNCRKKGKK-EDECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQ 158
           I W  P   +  C +KGK  + EC NF++ L   NASHL  CGT+AF PKC  +++  F 
Sbjct: 87  ISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNMLTFT 146

Query: 159 -QVERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDT 217
            +    E G+GKCP++PA+  A ++  G LY+AT+ N+LGTEPII R +G     ++T+ 
Sbjct: 147 LEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHS-MKTEY 205

Query: 218 LPSWLNAPAFVAAVALSPAEWGDEDGDDE-IYFFFTETSRAFDSYERIKVPRVARVCAGD 276
           L  WLN P FV + A  P   G   GDD+ +YFFF E +   D Y    V RVARVC GD
Sbjct: 206 LAFWLNEPHFVGS-AYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGD 264

Query: 277 LGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEG 336
           +GG +TLQ++WTTFLKA L C  P      + LQ +  L+      T  F+G+F +QW  
Sbjct: 265 MGGARTLQRKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDTSWHNTT-FFGVFQAQWGD 323

Query: 337 ATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGS 396
             +SA+C ++ ++I+ V  GP++E   +  +     D  VP PRPG CI N  +   + S
Sbjct: 324 MYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTD-PVPSPRPGSCINNWHRRHGYTS 382

Query: 397 SLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLG 456
           SL LPD +L F++ HPLM+  V P    PLLV   T +  +VA RVT L G  Y VL++G
Sbjct: 383 SLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIG 442

Query: 457 TEDGHLHRAVRIGAQLSVLEDLALFPEPQPVENMKLYHS--WLLVGSRTEVTQVNTTNCG 514
           T DG L +AV +G  + ++E+L LF + +P+ ++ L  S   L  GSR+++ Q+   +C 
Sbjct: 443 TGDGWLLKAVSLGPWVHLIEELQLF-DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADCM 501

Query: 515 RLQSCSECILAQDPVCAWSFRLDECVAHAGEHRG--LVQDIESADVSSLCPKEPGE--RP 570
           + +SC++C+LA+DP CAWS     CVA  G H G  L+Q + ++D S +C     +  RP
Sbjct: 502 KYRSCADCVLARDPYCAWSVNTSRCVA-VGGHSGSLLIQHVMTSDTSGICNLRGSKKVRP 560

Query: 571 VVFEVPVATAAHVVLPCSPSSAWASCVW---------HQPSGVTALTPRRDGLEVVVT-P 620
               + V     +VLPC  SS  A   W          QP G      R   L V+   P
Sbjct: 561 TPKNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQP-GSFLYDARLQALVVMAAQP 619

Query: 621 GAMGAYACECQEGGAAHVVAAY--SLVWGSQRDAPSRAHTVGAGLAGFFLGILAASLTLI 678
              GAY C  +E GA      Y  ++V G      +RA     GL    +  L A   ++
Sbjct: 620 RHAGAYHCFSEEQGARLAAEGYLVAVVAGPSVTLEARAPLENLGLVWLAVVALGAVCLVL 679

Query: 679 LIGRRQQRRRQRELLARDKVGLD--LGAPPSGTTSYSQDPPSPSPE-DERL--PLAL--- 730
           L+     RRR RE L +     +  L  P       +  P  P PE DE+L  P+     
Sbjct: 680 LLLVLSLRRRLREELEKGAKATERTLVYPLELPKEPTSPPFRPCPEPDEKLWDPVGYYYS 739

Query: 731 ----------AKRGSGFGGFSPPFLL--DPCPSPAHIRLTG 759
                     A+   G G  SPP  +   P PSP  + L G
Sbjct: 740 DGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGG 780


>gi|39777610 semaphorin 4B precursor [Homo sapiens]
          Length = 837

 Score =  391 bits (1004), Expect = e-108
 Identities = 254/670 (37%), Positives = 348/670 (51%), Gaps = 51/670 (7%)

Query: 10  PGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLL 69
           P    P   P  LLLL +L            PR SLP+   +    RF   H  NY+ LL
Sbjct: 15  PWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFLRFEAEHISNYTALL 74

Query: 70  VDPASHTLYVGARDTIFALSLPFS---GERPRRIDWMVPEAHRQNCRKKGKK-EDECHNF 125
           +     TLYVGAR+ +FALS   S   G   + + W      +Q C  KGK  + +C N+
Sbjct: 75  LSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNY 134

Query: 126 VQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVER------LESGRGKCPFEPAQRSA 179
           ++IL   + SHL TCGT AF P C  I++  F           LE G+G+CPF+P  +S 
Sbjct: 135 IKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPNFKST 194

Query: 180 AVMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWG 239
           A++  G LY  TV ++ G +P I+R+        +T++  +WL  PAFVA+ A  P   G
Sbjct: 195 ALVVDGELYTGTVSSFQGNDPAISRSQSLRPT--KTESSLNWLQDPAFVAS-AYIPESLG 251

Query: 240 DEDGDDE-IYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCP 298
              GDD+ IYFFF+ET + F+ +E   V R+AR+C GD GG + LQQRWT+FLKA LLC 
Sbjct: 252 SLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCS 311

Query: 299 GPEHGRASSVLQDVAVLRPE-LGAGTPIFYGIFSSQWEGATI--SAVCAFRPQDIRTVLN 355
            P+ G   +VLQDV  L P        +FYG+F+SQW   T   SAVC F  +D++ V +
Sbjct: 312 RPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFS 371

Query: 356 GPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMD 415
           G ++E+  +  +    V + VP PRPG CITN+ + R   SSL LPDRVL F++DH LMD
Sbjct: 372 GLYKEVNRETQQWY-TVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMD 430

Query: 416 RPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVL 475
             V       LL+     Y RV  HRV  L    YDVL+LGT DG LH+AV +G ++ ++
Sbjct: 431 GQV---RSRMLLLQPQARYQRVAVHRVPGLH-HTYDVLFLGTGDGRLHKAVSVGPRVHII 486

Query: 476 EDLALFPEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWS 533
           E+L +F   QPV+N+ L  +   L   S + V QV   NC   +SC +C+LA+DP CAWS
Sbjct: 487 EELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYCAWS 546

Query: 534 FRLDECVAHAGEH------RGLVQDIESADVSSLCPKE---------PGERPVVFEVPVA 578
                   H   +      R  +QDIE A    LC             GE+P   +V   
Sbjct: 547 ---GSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCE-QVQFQ 602

Query: 579 TAAHVVLPCSPSSAWASCVWHQ---PSGVTA---LTPRRDGLEVVVTPGAMGAYACECQE 632
                 L C   S  A+ +W +   P   +A   + P  D L  +V    +G + C   E
Sbjct: 603 PNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLL--LVGTQQLGEFQCWSLE 660

Query: 633 GGAAHVVAAY 642
            G   +VA+Y
Sbjct: 661 EGFQQLVASY 670


>gi|39777608 semaphorin 4B precursor [Homo sapiens]
          Length = 837

 Score =  391 bits (1004), Expect = e-108
 Identities = 254/670 (37%), Positives = 348/670 (51%), Gaps = 51/670 (7%)

Query: 10  PGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLL 69
           P    P   P  LLLL +L            PR SLP+   +    RF   H  NY+ LL
Sbjct: 15  PWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFLRFEAEHISNYTALL 74

Query: 70  VDPASHTLYVGARDTIFALSLPFS---GERPRRIDWMVPEAHRQNCRKKGKK-EDECHNF 125
           +     TLYVGAR+ +FALS   S   G   + + W      +Q C  KGK  + +C N+
Sbjct: 75  LSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNY 134

Query: 126 VQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVER------LESGRGKCPFEPAQRSA 179
           ++IL   + SHL TCGT AF P C  I++  F           LE G+G+CPF+P  +S 
Sbjct: 135 IKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPNFKST 194

Query: 180 AVMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWG 239
           A++  G LY  TV ++ G +P I+R+        +T++  +WL  PAFVA+ A  P   G
Sbjct: 195 ALVVDGELYTGTVSSFQGNDPAISRSQSLRPT--KTESSLNWLQDPAFVAS-AYIPESLG 251

Query: 240 DEDGDDE-IYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCP 298
              GDD+ IYFFF+ET + F+ +E   V R+AR+C GD GG + LQQRWT+FLKA LLC 
Sbjct: 252 SLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCS 311

Query: 299 GPEHGRASSVLQDVAVLRPE-LGAGTPIFYGIFSSQWEGATI--SAVCAFRPQDIRTVLN 355
            P+ G   +VLQDV  L P        +FYG+F+SQW   T   SAVC F  +D++ V +
Sbjct: 312 RPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFS 371

Query: 356 GPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMD 415
           G ++E+  +  +    V + VP PRPG CITN+ + R   SSL LPDRVL F++DH LMD
Sbjct: 372 GLYKEVNRETQQWY-TVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMD 430

Query: 416 RPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVL 475
             V       LL+     Y RV  HRV  L    YDVL+LGT DG LH+AV +G ++ ++
Sbjct: 431 GQV---RSRMLLLQPQARYQRVAVHRVPGLH-HTYDVLFLGTGDGRLHKAVSVGPRVHII 486

Query: 476 EDLALFPEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWS 533
           E+L +F   QPV+N+ L  +   L   S + V QV   NC   +SC +C+LA+DP CAWS
Sbjct: 487 EELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYCAWS 546

Query: 534 FRLDECVAHAGEH------RGLVQDIESADVSSLCPKE---------PGERPVVFEVPVA 578
                   H   +      R  +QDIE A    LC             GE+P   +V   
Sbjct: 547 ---GSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCE-QVQFQ 602

Query: 579 TAAHVVLPCSPSSAWASCVWHQ---PSGVTA---LTPRRDGLEVVVTPGAMGAYACECQE 632
                 L C   S  A+ +W +   P   +A   + P  D L  +V    +G + C   E
Sbjct: 603 PNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLL--LVGTQQLGEFQCWSLE 660

Query: 633 GGAAHVVAAY 642
            G   +VA+Y
Sbjct: 661 EGFQQLVASY 670


>gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]
          Length = 862

 Score =  387 bits (995), Expect = e-107
 Identities = 231/630 (36%), Positives = 347/630 (55%), Gaps = 31/630 (4%)

Query: 22  LLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGA 81
           L+ LAV+ G      P  +PR +    E    L +F  P  YNYS LL+     TLY+GA
Sbjct: 11  LMALAVMFGTAMAFAP--IPRITWEHREVH--LVQFHEPDIYNYSALLLSEDKDTLYIGA 66

Query: 82  RDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGK-KEDECHNFVQILAIANASHLLTC 140
           R+ +FA++     E+   + W V E  +  C +KGK K+ EC N++++L   +A+ L  C
Sbjct: 67  REAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVC 126

Query: 141 GTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEP 200
           GT AF P C  ++++ F+ + + E G+G+CPF+PA    +VM  G LY+ T  N+LG+EP
Sbjct: 127 GTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEP 186

Query: 201 IITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDS 260
           II+R    +   +RT+    WLN P+FV A  +  +    +  DD +YFFFTE S  ++ 
Sbjct: 187 IISRNSSHSP--LRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEF 244

Query: 261 YERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQDVAVLRPELG 320
             R+ +PR+ARVC GD GG +TLQ++WT+FLKA L+C  P+ G   +VL+DV VLR   G
Sbjct: 245 VFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSP-G 303

Query: 321 AGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLN-GPFRELK--HDCNRGLPVVDNDVP 377
              P+FY +F+ Q     +SAVCA+       V + G + +       +      +  VP
Sbjct: 304 LKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVP 363

Query: 378 QPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAYLRV 437
           +PRPG CI +  +  ++ SSL+LPD+ L F++DHPLMD  V P D  P L+  D  Y ++
Sbjct: 364 KPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQI 423

Query: 438 VAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPEPQPVENM----KLY 493
           V  R  +L G  YDV+++ T+ G LH+A+ +   + ++E+  LF + +PV+ +    K  
Sbjct: 424 VVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKG 483

Query: 494 HSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECVA-HAGE--HRGLV 550
           + ++  GS + V Q     CG+  +C +C+LA+DP CAWS     CVA H  E   RGL+
Sbjct: 484 NRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLI 543

Query: 551 QDIESADVSSLCP-KEPGERPVVFEVPVATAAHVVLPCSPSSAWASCVWHQPSGVT---- 605
           Q++ S D +S+CP K  G     F     TA    L CS  S  A   W   +GV     
Sbjct: 544 QEM-SGD-ASVCPDKSKGSYRQHFFKHGGTAE---LKCSQKSNLARVFWKFQNGVLKAES 598

Query: 606 ---ALTPRRDGLEVVVTPGAMGAYACECQE 632
               L  R++ L   ++ G  G Y C  +E
Sbjct: 599 PKYGLMGRKNLLIFNLSEGDSGVYQCLSEE 628


>gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]
          Length = 738

 Score =  379 bits (972), Expect = e-105
 Identities = 210/553 (37%), Positives = 320/553 (57%), Gaps = 20/553 (3%)

Query: 22  LLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGA 81
           L+ LAV+ G      P  +PR +    E    L +F  P  YNYS LL+     TLY+GA
Sbjct: 11  LMALAVMFGTAMAFAP--IPRITWEHREVH--LVQFHEPDIYNYSALLLSEDKDTLYIGA 66

Query: 82  RDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGK-KEDECHNFVQILAIANASHLLTC 140
           R+ +FA++     E+   + W V E  +  C +KGK K+ EC N++++L   +A+ L  C
Sbjct: 67  REAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVC 126

Query: 141 GTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEP 200
           GT AF P C  ++++ F+ + + E G+G+CPF+PA    +VM  G LY+ T  N+LG+EP
Sbjct: 127 GTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEP 186

Query: 201 IITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDS 260
           II+R    +   +RT+    WLN P+FV A  +  +    +  DD +YFFFTE S  ++ 
Sbjct: 187 IISRNSSHSP--LRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEF 244

Query: 261 YERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQDVAVLRPELG 320
             R+ +PR+ARVC GD GG +TLQ++WT+FLKA L+C  P+ G   +VL+DV VLR   G
Sbjct: 245 VFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSP-G 303

Query: 321 AGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLN-GPFRELK--HDCNRGLPVVDNDVP 377
              P+FY +F+ Q     +SAVCA+       V + G + +       +      +  VP
Sbjct: 304 LKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVP 363

Query: 378 QPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAYLRV 437
           +PRPG CI +  +  ++ SSL+LPD+ L F++DHPLMD  V P D  P L+  D  Y ++
Sbjct: 364 KPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQI 423

Query: 438 VAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPEPQPVENM----KLY 493
           V  R  +L G  YDV+++ T+ G LH+A+ +   + ++E+  LF + +PV+ +    K  
Sbjct: 424 VVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKG 483

Query: 494 HSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECVA-HAGE--HRGLV 550
           + ++  GS + V Q     CG+  +C +C+LA+DP CAWS     CVA H  E   RGL+
Sbjct: 484 NRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLI 543

Query: 551 QDIESADVSSLCP 563
           Q++ S D +S+CP
Sbjct: 544 QEM-SGD-ASVCP 554


>gi|28872814 semaphorin 4G [Homo sapiens]
          Length = 843

 Score =  360 bits (923), Expect = 4e-99
 Identities = 254/722 (35%), Positives = 364/722 (50%), Gaps = 66/722 (9%)

Query: 23  LLLAVLS-----GPVSGRVPRSV---PRTSLPISEADSCLTRFAVPHTYNYSVLLVDPAS 74
           LLL++L+     GP   R  R +   PR ++P  E     TR       NYS LL++ AS
Sbjct: 8   LLLSILTATAVPGPSLRRPSRELDATPRMTIPYEELSG--TRHFKGQAQNYSTLLLEEAS 65

Query: 75  HTLYVGARDTIFALSLPFSGERPRR-IDWMVPEAHRQNCRKKGKK-EDECHNFVQILAIA 132
             L VGAR  +F+LS    G+   + I W      +  C +KGK  + EC N V+ L   
Sbjct: 66  ARLLVGARGALFSLSANDIGDGAHKEIHWEASPEMQSKCHQKGKNNQTECFNHVRFLQRL 125

Query: 133 NASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYAATV 192
           N++HL  CGT AF P C  ID   F      E G+ KCP++PA+    ++  G LY AT 
Sbjct: 126 NSTHLYACGTHAFQPLCAAIDAEAFTLPTSFEEGKEKCPYDPARGFTGLIIDGGLYTATR 185

Query: 193 KNYLGTEPIITRAVGRAEDWIRTDTLPS-WLNAPAFVAAVALSPAEWGDEDGDDEIYFFF 251
             +    P I R+  R    +RT+  P  WLN   FV +V +  ++      DD++Y+FF
Sbjct: 186 YEFRSI-PDIRRS--RHPHSLRTEETPMHWLNDAEFVFSVLVRESKASAVGDDDKVYYFF 242

Query: 252 TE--TSRAFDSYERIK----VPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRA 305
           TE  T     S+ + +    V RVARVC GDLGG+K LQ++WT+FLKA L+C  P +   
Sbjct: 243 TERATEEGSGSFTQSRSSHRVARVARVCKGDLGGKKILQKKWTSFLKARLICHIPLY--- 299

Query: 306 SSVLQDVAVLRPELGAGTPIFYGIF--SSQWEGATISAVCAFRPQDIRTVLNGPFRELKH 363
              L+ V  L  E  + T  FY  F  S+QW+    SA+C +   +I+ V  GP+ E + 
Sbjct: 300 -ETLRGVCSLDAETSSRTH-FYAAFTLSTQWKTLEASAICRYDLAEIQAVFAGPYMEYQ- 356

Query: 364 DCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADG 423
           D +R     +  VP+PRPG CIT++++ + + SS  LP  VL F++ HPLM RPV P  G
Sbjct: 357 DGSRRWGRYEGGVPEPRPGSCITDSLRSQGYNSSQDLPSLVLDFVKLHPLMARPVVPTRG 416

Query: 424 HPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPE 483
            PLL+  +  Y  +    VT+ +G  YD+L+LGT DG +H+AV +G+ + ++E+  +F E
Sbjct: 417 RPLLLKRNIRYTHLTGTPVTTPAGPTYDLLFLGTADGWIHKAVVLGSGMHIIEETQVFRE 476

Query: 484 PQPVENM---KLYHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECV 540
            Q VEN+    L HS L VG+ + V Q+  ++C R +SC +CILA+DP C W      C 
Sbjct: 477 SQSVENLVISLLQHS-LYVGAPSGVIQLPLSSCSRYRSCYDCILARDPYCGWDPGTHACA 535

Query: 541 A-------HAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPVATAAHVVLPCSPSSAW 593
           A         G    L+QDIE  +      ++ G  P +    V     V+LPC   S  
Sbjct: 536 AATTIANRSQGSRTALIQDIERGNRGCESSRDTGPPPPLKTRSVLRGDDVLLPCDQPSNL 595

Query: 594 ASCVWHQPSGVTALTPRRDGLEVVV--------TPGAMGAYACECQEGGAAHVVAAYSLV 645
           A  +W   +G   L+  + G  V V         P   G Y C  +E G   ++A+YSL 
Sbjct: 596 ARALW-LLNGSMGLSDGQGGYRVGVDGLLVTDAQPEHSGNYGCYAEENGLRTLLASYSLT 654

Query: 646 W--GSQRDAPSRAHTVGAGLA--------------GFFLGILAASLTLILIGRRQQRRRQ 689
               +   AP    T GA LA              G    ILA+SL  +   R  +R R+
Sbjct: 655 VRPATPAPAPKAPATPGAQLAPDVRLLYVLAIAALGGLCLILASSLLYVACLREGRRGRR 714

Query: 690 RE 691
           R+
Sbjct: 715 RK 716


>gi|21361914 semaphorin B [Homo sapiens]
          Length = 761

 Score =  337 bits (865), Expect = 2e-92
 Identities = 230/658 (34%), Positives = 328/658 (49%), Gaps = 58/658 (8%)

Query: 20  FPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYV 79
           F LL L + +    G     +PR      +    L+ F      ++  LL+    +TLYV
Sbjct: 19  FQLLQLLLPTTTAGGGGQGPMPRVRYYAGDERRALSFFHQKGLQDFDTLLLSGDGNTLYV 78

Query: 80  GARDTIFALSLPFSGERPR---RIDWMVPEAHRQNCR-KKGKKEDECHNFVQILAIANAS 135
           GAR+ I AL +   G  PR    I W   +  +  C  KK   E +C NF+++L   N +
Sbjct: 79  GAREAILALDIQDPGV-PRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVT 137

Query: 136 HLLTCGTFAFDPKCGVIDVSRFQQV----ERLESGRGKCPFEPAQRSAAVMAGGVLYAAT 191
           HL TCGTFAF P C  I++     +    +++  G+G+ PF+PA +  AV+  G+LY+ T
Sbjct: 138 HLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGT 197

Query: 192 VKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPA-FVAAVALSPAEWGDEDGDDEIYFF 250
           + N+LG+EPI+ R +G ++  ++TD    WL+  A FVAA+  +            +YFF
Sbjct: 198 MNNFLGSEPILMRTLG-SQPVLKTDNFLRWLHHDASFVAAIPSTQV----------VYFF 246

Query: 251 FTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQ 310
           F ET+  FD +ER+   RVARVC  D+GG K LQ++WTTFLKA LLC  P  G+    + 
Sbjct: 247 FEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQP--GQLPFNVI 304

Query: 311 DVAVLRPELGAGTPIFYGIFSSQWE--GATISAVCAFRPQDIRTVLNGPFRELKHDCNRG 368
             AVL P      P  Y +F+SQW+  G   SAVCAF   DI  V  G ++EL  + +R 
Sbjct: 305 RHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRW 364

Query: 369 LPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLV 428
                 +   PRPG C          G S    D+ LTF++DH LMD  V    G PLLV
Sbjct: 365 TTYRGPET-NPRPGSC--------SVGPS---SDKALTFMKDHFLMDEQVV---GTPLLV 409

Query: 429 TTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIG-AQLSVLEDLALFPEPQPV 487
            +   Y R+       L G  + V+YLGT  G LH+AV  G +   ++E++ LFP+P+PV
Sbjct: 410 KSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAHLVEEIQLFPDPEPV 469

Query: 488 ENMKL--YHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDE-CVAHAG 544
            N++L      + VG    V +V   NC   +SC +C+LA+DP CAW       C+  A 
Sbjct: 470 RNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESCVDCVLARDPHCAWDPESRTCCLLSAP 529

Query: 545 EHRGLVQDIESADVSSLCPKEPGER--------PVVFEVPVATAAHVVLPCSPSSAWASC 596
                 QD+E  +    C   P  R         ++ EV     + + LPC   SA AS 
Sbjct: 530 NLNSWKQDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPCPHLSALASY 589

Query: 597 VW-HQPSGV--TALTPRRDGLEVVVTPGAMGAYACECQEGGAAHVVAAYSLVWGSQRD 651
            W H P+ V   + T     L ++V  G  G Y C   E G ++ V +Y   W   +D
Sbjct: 590 YWSHGPAAVPEASSTVYNGSLLLIVQDGVGGLYQCWATENGFSYPVISY---WVDSQD 644


>gi|41406086 semaphorin 3D [Homo sapiens]
          Length = 777

 Score =  296 bits (759), Expect = 4e-80
 Identities = 207/668 (30%), Positives = 324/668 (48%), Gaps = 55/668 (8%)

Query: 22  LLLLAVLSGPVSGRVPRSVPRTSLPISE---ADSCLTRFAVPHTYNYSVLLVDPASHTLY 78
           +L + +L  PV+G + +++PR  L   +   ++SC+         ++  LL+D     L 
Sbjct: 24  MLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLL 83

Query: 79  VGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKED-ECHNFVQILAIANASHL 137
           +GA+D IF LSL    +  ++I W   +   + C+  GK  + EC NF+++L   N +H+
Sbjct: 84  LGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHI 143

Query: 138 LTCGTFAFDPKCGVIDVSRFQQ-------VERLESGRGKCPFEPAQRSAAVMAGGVLYAA 190
             CGT AF P CG ID+  +++          LESGR KCPF+P Q  A+VM    LY+ 
Sbjct: 144 YVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSG 203

Query: 191 TVKNYLGTEPIITRAVGRAED--WIRTDTLPS-WLNAPAFVAAVALSPAEWGDEDGDDEI 247
           T  ++LG +   TR++G   D  +IRTD     WLN   F+    +      D   DD+I
Sbjct: 204 TASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPD---DDKI 260

Query: 248 YFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASS 307
           YFFF E+S+   + ++  + RV RVC  D+GG+++L  +WTTFLKA L+C  P    A +
Sbjct: 261 YFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPGSDGADT 320

Query: 308 V---LQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHD 364
               LQD+ +L P      P+ YG+F++       SAVC +   DIR V NGP+   K  
Sbjct: 321 YFDELQDIYLL-PTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAH-KES 378

Query: 365 CNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGH 424
            +      D  +P PRPG C +         S+   PD V++FI+ H +M + V+P  G 
Sbjct: 379 ADHRWVQYDGRIPYPRPGTCPSKTYD-PLIKSTRDFPDDVISFIKRHSVMYKSVYPVAGG 437

Query: 425 PLL--VTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQL-----SVLED 477
           P    +  D    ++V   V +  G +YDV++LGT+ G + + V I  +       VLE+
Sbjct: 438 PTFKRINVDYRLTQIVVDHVIAEDG-QYDVMFLGTDIGTVLKVVSISKEKWNMEEVVLEE 496

Query: 478 LALFPEPQPVENMK--LYHSWLLVGSRTEVTQVNTTNCGRL-QSCSECILAQDPVCAWSF 534
           L +F     + NM+  L    L +GSR  + Q++   C    ++C++C LA+DP CAW  
Sbjct: 497 LQIFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKACADCCLARDPYCAWDG 556

Query: 535 RLDECVAHAGEHRGLVQDIESADVSSLC-------PKEPGERPVVFEVPVATAAHVVLPC 587
                 A   + R   QD++  D  + C         E  +  V+F +   +     L C
Sbjct: 557 NACSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHETADEKVIFGIEFNS---TFLEC 613

Query: 588 SPSSAWASCVWH-QPSGVTALTPRRDGLEVVVTPGAM----------GAYACECQEGGAA 636
            P S  A+  W+ Q SG       +    ++ T   +          G Y C+ QE    
Sbjct: 614 IPKSQQATIKWYIQRSGDEHREELKPDERIIKTEYGLLIRSLQKKDSGMYYCKAQEHTFI 673

Query: 637 HVVAAYSL 644
           H +   +L
Sbjct: 674 HTIVKLTL 681


>gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]
          Length = 749

 Score =  295 bits (754), Expect = 1e-79
 Identities = 211/614 (34%), Positives = 308/614 (50%), Gaps = 42/614 (6%)

Query: 25  LAVLSGPVSGRVPRSVPRTSLPISEADSC--LTRFAVPHTYNYSVLLVDPASHTLYVGAR 82
           LA+L     G    S PR  L   E  +   L  F++  T  Y  LLVD     L+VGA 
Sbjct: 13  LALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFVGAE 72

Query: 83  DTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKK-EDECHNFVQILAIANASHLLTCG 141
           + + +L+L    +R +++ W  P   R+ C   GK    EC NFV++L   N +HLL CG
Sbjct: 73  NHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLLACG 132

Query: 142 TFAFDPKCGVIDVSRFQQVE-------RLESGRGKCPFEPAQRSAAVMAGGVLYAATVKN 194
           T AF P C  ++V    +         R+E G+GK P++P  R+A+V+ G  LY+    +
Sbjct: 133 TGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGVAAD 192

Query: 195 YLGTEPIITRAVGRAEDWIRTDTLPS-WLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTE 253
            +G +  I R++G+    +RT+   S WLN P FV    +  +E  D   DD+IYFFF E
Sbjct: 193 LMGRDFTIFRSLGQRPS-LRTEPHDSRWLNEPKFVKVFWIPESENPD---DDKIYFFFRE 248

Query: 254 TS-RAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLC--PGPEHGRASSVLQ 310
           T+  A  +  R+ V RV ++C  D+GG+++L  +WTTFLKA L+C  PG E       LQ
Sbjct: 249 TAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQ 308

Query: 311 DVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLP 370
           DV +L       TP+ Y +FS+       SAVC +   D+R    GPF   +   ++ + 
Sbjct: 309 DVFLLSSR-DHRTPLLYAVFSTSSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVS 367

Query: 371 VVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLL--V 428
                VP PRPG C +       F S+   PD V+ F R+HPLM   V P  G PL   V
Sbjct: 368 -YQGRVPYPRPGMCPSKTFGT--FSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQV 424

Query: 429 TTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAV------RIGAQLSVLEDLALFP 482
             +  + ++ A RV +  G  YDVL++GT+ G + + +      R  A+  +LE+L +F 
Sbjct: 425 GANYTFTQIAADRVAAADG-HYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFE 483

Query: 483 EPQPVENMKL--YHSWLLVGSRTEVTQVNTTNC---GRLQSCSECILAQDPVCAWSFRLD 537
           +   V +M++      L V SR+ V Q+    C   GR+  C+EC LA+DP CAW     
Sbjct: 484 DSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRV--CTECCLARDPYCAWDGVAC 541

Query: 538 ECVAHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPV--ATAAHVVLPCSPSSAWAS 595
                + + R   QD+ + D S+LC  +   RP + E  V     +   L C P S  A 
Sbjct: 542 TRFQPSAKRRFRRQDVRNGDPSTLCSGD-SSRPALLEHKVFGVEGSSAFLECEPRSLQAR 600

Query: 596 CVW-HQPSGVTALT 608
             W  Q +GVTA T
Sbjct: 601 VEWTFQRAGVTAHT 614


>gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]
          Length = 748

 Score =  293 bits (750), Expect = 4e-79
 Identities = 213/616 (34%), Positives = 311/616 (50%), Gaps = 47/616 (7%)

Query: 25  LAVLSGPVSGRVPRSVPRTSLPISEADSC--LTRFAVPHTYNYSVLLVDPASHTLYVGAR 82
           LA+L     G    S PR  L   E  +   L  F++  T  Y  LLVD     L+VGA 
Sbjct: 13  LALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFVGAE 72

Query: 83  DTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKK-EDECHNFVQILAIANASHLLTCG 141
           + + +L+L    +R +++ W  P   R+ C   GK    EC NFV++L   N +HLL CG
Sbjct: 73  NHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLLACG 132

Query: 142 TFAFDPKCGVIDVSRFQQVE-------RLESGRGKCPFEPAQRSAAVMAGGVLYAATVKN 194
           T AF P C  ++V    +         R+E G+GK P++P  R+A+V+ G  LY+    +
Sbjct: 133 TGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGVAAD 192

Query: 195 YLGTEPIITRAVGRAEDWIRTDTLPS-WLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTE 253
            +G +  I R++G+    +RT+   S WLN P FV    +  +E  D   DD+IYFFF E
Sbjct: 193 LMGRDFTIFRSLGQRPS-LRTEPHDSRWLNEPKFVKVFWIPESENPD---DDKIYFFFRE 248

Query: 254 TS-RAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLC--PGPEHGRASSVLQ 310
           T+  A  +  R+ V RV ++C  D+GG+++L  +WTTFLKA L+C  PG E       LQ
Sbjct: 249 TAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQ 308

Query: 311 DVAVLRPELGAGTPIFYGIF--SSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCNRG 368
           DV +L       TP+ Y +F  SS ++G   SAVC +   D+R    GPF   +   ++ 
Sbjct: 309 DVFLLSSR-DHRTPLLYAVFSTSSIFQG---SAVCVYSMNDVRRAFLGPFAHKEGPMHQW 364

Query: 369 LPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLL- 427
           +      VP PRPG C +       F S+   PD V+ F R+HPLM   V P  G PL  
Sbjct: 365 VS-YQGRVPYPRPGMCPSKTFGT--FSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFL 421

Query: 428 -VTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAV------RIGAQLSVLEDLAL 480
            V  +  + ++ A RV +  G  YDVL++GT+ G + + +      R  A+  +LE+L +
Sbjct: 422 QVGANYTFTQIAADRVAAADG-HYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHV 480

Query: 481 FPEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNC---GRLQSCSECILAQDPVCAWSFR 535
           F +   V +M++      L V SR+ V Q+    C   GR+  C+EC LA+DP CAW   
Sbjct: 481 FEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRV--CTECCLARDPYCAWDGV 538

Query: 536 LDECVAHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPV--ATAAHVVLPCSPSSAW 593
                  + + R   QD+ + D S+LC  +   RP + E  V     +   L C P S  
Sbjct: 539 ACTRFQPSAKRRFRRQDVRNGDPSTLCSGD-SSRPALLEHKVFGVEGSSAFLECEPRSLQ 597

Query: 594 ASCVW-HQPSGVTALT 608
           A   W  Q +GVTA T
Sbjct: 598 ARVEWTFQRAGVTAHT 613


>gi|9910362 semaphorin sem2 [Homo sapiens]
          Length = 782

 Score =  276 bits (706), Expect = 5e-74
 Identities = 228/675 (33%), Positives = 319/675 (47%), Gaps = 68/675 (10%)

Query: 22  LLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAV----PHTYNYSVLLVDPASHTL 77
           LLL    SGP  G    SVPR  L   +  S   R A+      + N   + +D     L
Sbjct: 15  LLLHGGSSGPSPGP---SVPRLRLSYRDLLSA-NRSAIFLGPQGSLNLQAMYLDEYRDRL 70

Query: 78  YVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKE-DECHNFVQILAIANASH 136
           ++G  D +++L L  +   PR + W      R+ C +KG+    EC NFV++L   N +H
Sbjct: 71  FLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFVRVLQPHNRTH 130

Query: 137 LLTCGTFAFDPKCGVIDVS-RFQQVERLE-----SGRGKCPFEPAQRSAAVMAGGVLYAA 190
           LL CGT AF P C +I V  R + V  LE     SGRG+CP EP++  A+    G LY  
Sbjct: 131 LLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFASTFIDGELYTG 190

Query: 191 TVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGDEDGDDEIYFF 250
              ++LG E +I R+ G     +R+D+  S L+ P FV A  +   E  D+D +D++YFF
Sbjct: 191 LTADFLGREAMIFRS-GGPRPALRSDSDQSLLHDPRFVMAARIP--ENSDQD-NDKVYFF 246

Query: 251 FTETSRAFDS-YERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASS-- 307
           F+ET  + D     + V RV RVC  D GG++ L  +W+TFLKA L+C  P  G A +  
Sbjct: 247 FSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPGGAETHF 306

Query: 308 -VLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCN 366
             L+DV +L P+ G    + Y +FS+        AVC +   DI  V NGPF       +
Sbjct: 307 DQLEDVFLLWPKAGKSLEV-YALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHRDGPQH 365

Query: 367 RGLPVVDNDVPQPRPGECITNNMKL--RHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGH 424
           +  P     VP PRPG C +       R FGS+   PD VL F R HPLM  PV P  G 
Sbjct: 366 QWGP-YGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRPRHGR 424

Query: 425 PLLVTTDTAYL--RVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLS------VLE 476
           P+LV T  A    ++V  RV +  G  YDV++LGT+ G + + + + A  S      VLE
Sbjct: 425 PVLVKTHLAQQLHQIVVDRVEAEDG-TYDVIFLGTDSGSVLKVIALQAGGSAEPEEVVLE 483

Query: 477 DLALFPEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNCGRL-QSCSECILAQDPVCAWS 533
           +L +F  P P+  M++      L VGSR  V Q+    C     +C+EC LA+DP CAW 
Sbjct: 484 ELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYCAWD 543

Query: 534 FRLDECVAH---AGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPVATAAHVVLPCSPS 590
                C  +    G+ R   QDI   + +  C  +  E   V  V    AA +V     +
Sbjct: 544 GA--SCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLV----AATMVYGTEHN 597

Query: 591 SAWASCVWHQPSGVTALTPRRDGLE----------VVVTPGAM----------GAYACEC 630
           S +  C+   P        +R G E          V+ T   +          G Y C  
Sbjct: 598 STFLECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTT 657

Query: 631 QEGGAAHVVAAYSLV 645
            E G +  V   +LV
Sbjct: 658 LEHGFSQTVVRLALV 672


>gi|5174673 semaphorin 3A precursor [Homo sapiens]
          Length = 771

 Score =  270 bits (690), Expect = 4e-72
 Identities = 189/591 (31%), Positives = 290/591 (49%), Gaps = 41/591 (6%)

Query: 39  SVPRTSLPISE---ADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGE 95
           +VPR  L   E   +++ +T   + ++ +Y   L+D     LYVGA+D IF+  L  + +
Sbjct: 28  NVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFDL-VNIK 86

Query: 96  RPRRIDWMVPEAHRQNCRKKGKKE-DECHNFVQILAIANASHLLTCGTFAFDPKCGVIDV 154
             ++I W V    R  C+  GK    EC NF+++L   N +HL  CGT AF P C  I++
Sbjct: 87  DFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEI 146

Query: 155 SRFQQVE-------RLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEPIITRAVG 207
               +           E+GRGK P++P   +A+++  G LY+ T  +++G +  I R +G
Sbjct: 147 GHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLG 206

Query: 208 RAEDWIRTDTLPS-WLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKV 266
                IRT+   S WLN P F++A  +S +   D   DD++YFFF E +   +   +   
Sbjct: 207 HHHP-IRTEQHDSRWLNDPKFISAHLISES---DNPEDDKVYFFFRENAIDGEHSGKATH 262

Query: 267 PRVARVCAGDLGGRKTLQQRWTTFLKADLLC--PGPEH-GRASSVLQDVAVLRPELGAGT 323
            R+ ++C  D GG ++L  +WTTFLKA L+C  PGP         LQDV ++  +     
Sbjct: 263 ARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFK-DPKN 321

Query: 324 PIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGE 383
           P+ YG+F++       SAVC +   D+R V  GP+        + +P     VP PRPG 
Sbjct: 322 PVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVP-YQGRVPYPRPGT 380

Query: 384 CITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAY--LRVVAHR 441
           C +       F S+  LPD V+TF R HP M  PVFP +  P+++ TD  Y   ++V  R
Sbjct: 381 CPSKT--FGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDR 438

Query: 442 VTSLSGKEYDVLYLGTEDGHLHRAVRIGAQL------SVLEDLALFPEPQPVENMKL--Y 493
           V +  G +YDV+++GT+ G + + V I  +        +LE++ +F EP  +  M+L   
Sbjct: 439 VDAEDG-QYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTK 497

Query: 494 HSWLLVGSRTEVTQVNTTNCGRL-QSCSECILAQDPVCAWSFRLDECVAHAGEHRGLVQD 552
              L +GS   V Q+    C    ++C+EC LA+DP CAW            + R   QD
Sbjct: 498 QQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSACSRYFPTAKRRTRRQD 557

Query: 553 IESADVSSLC-----PKEPGERPVVFEVPVATAAHVVLPCSPSSAWASCVW 598
           I + D  + C         G  P    +     +   L CSP S  A   W
Sbjct: 558 IRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKSQRALVYW 608


>gi|6912650 semaphorin 3E [Homo sapiens]
          Length = 775

 Score =  259 bits (661), Expect = 9e-69
 Identities = 190/619 (30%), Positives = 292/619 (47%), Gaps = 51/619 (8%)

Query: 68  LLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKEDECHNFVQ 127
           +L+D     L+VG RD +++LSL    +  + I W       + C  KGK   EC N+V+
Sbjct: 61  MLLDEYQERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDAGECANYVR 120

Query: 128 ILAIANASHLLTCGTFAFDPKCGVIDVSR-------FQQVERLESGRGKCPFEPAQRSAA 180
           +L   N +HLLTCGT AFDP C  I V           +  R E GRG+CPF+P+    +
Sbjct: 121 VLHHYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFIS 180

Query: 181 VMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTD-TLPSWLNAPAFVAAVALSPAEWG 239
            + G  L+A    +Y   +  I R++GR    IRT+      L  P FV +  +   E  
Sbjct: 181 TLIGSELFAGLYSDYWSRDAAIFRSMGRLAH-IRTEHDDERLLKEPKFVGSYMIPDNE-- 237

Query: 240 DEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPG 299
           D D D+++YFFFTE +   ++       RV R+C  D+GG++ L  +W+TFLKA L+C  
Sbjct: 238 DRD-DNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSV 296

Query: 300 PEHGRASSV---LQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNG 356
           P      +    L+DV +L P      P+ +G+F++        A+C +    IR   NG
Sbjct: 297 PGMNGIDTYFDELEDVFLL-PTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNG 355

Query: 357 PFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDR 416
           P+   K        V +  VP PRPG C  + +    +G++   PD  + F R HPLM +
Sbjct: 356 PYAH-KEGPEYHWSVYEGKVPYPRPGSC-ASKVNGGRYGTTKDYPDDAIRFARSHPLMYQ 413

Query: 417 PVFPADGHPLLVTTDTAY--LRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRI------ 468
            + PA   P+LV TD  Y   ++   RV +  G +YDVL++GT++G + + + I      
Sbjct: 414 AIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDG-QYDVLFIGTDNGIVLKVITIYNQEME 472

Query: 469 GAQLSVLEDLALFPEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNCGRLQS-CSECILA 525
             +  +LE+L +F +P P+ +M++      L +GS + V QV   +C    S C++C LA
Sbjct: 473 SMEEVILEELQIFKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLA 532

Query: 526 QDPVCAWS----FRLDECVAHAGEHRGLVQDIESADVSSLC--PKEPGERPVVFEVPVAT 579
           +DP CAW      R      HA + R   QD+   + +  C   +  G+     E  +A 
Sbjct: 533 RDPYCAWDGISCSRYYPTGTHA-KRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAY 591

Query: 580 AAH---VVLPCSPSSAWASCVWHQPSG--VTALTPRRDGLEVVVTPGAM---------GA 625
                  +L C+P S  A  +W    G        + D   V +  G +         G 
Sbjct: 592 GIENNSTLLECTPRSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGT 651

Query: 626 YACECQEGGAAHVVAAYSL 644
           Y C+  E    H V   +L
Sbjct: 652 YFCQTVEHSFVHTVRKITL 670


>gi|5454048 semaphorin 3C [Homo sapiens]
          Length = 751

 Score =  253 bits (646), Expect = 5e-67
 Identities = 181/569 (31%), Positives = 273/569 (47%), Gaps = 46/569 (8%)

Query: 61  HTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKED 120
           H  +Y +LL+D     +YVG++D I +L++    +    + W       + C+  GK   
Sbjct: 50  HPLDYRILLMDEDQDRIYVGSKDHILSLNINNISQEALSVFWPASTIKVEECKMAGKDPT 109

Query: 121 E-CHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSR------FQQVERLESGRGKCPFE 173
             C NFV+++   N +HL  CG+ AF P C  ++  R      F    + ESG+G+C F 
Sbjct: 110 HGCGNFVRVIQTFNRTHLYVCGSGAFSPVCTYLNRGRRSEDQVFMIDSKCESGKGRCSFN 169

Query: 174 PAQRSAAVMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPS-WLNAPAFVAAVA 232
           P   + +VM    L++    +++GT+  I R++ +  + +RTD   S WL+ P FV A  
Sbjct: 170 PNVNTVSVMINEELFSGMYIDFMGTDAAIFRSLTK-RNAVRTDQHNSKWLSEPMFVDAHV 228

Query: 233 LSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLK 292
           +     G +  D ++YFFF E     +   +     +AR+C  D GG ++L  +WTTFLK
Sbjct: 229 IPD---GTDPNDAKVYFFFKEKLTDNNRSTKQIHSMIARICPNDTGGLRSLVNKWTTFLK 285

Query: 293 ADLLC-----PGPEHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRP 347
           A L+C      GPE       L+DV +L  +    T + YGIF++       SAVC +  
Sbjct: 286 ARLVCSVTDEDGPE--THFDELEDVFLLETD-NPRTTLVYGIFTTSSSVFKGSAVCVYHL 342

Query: 348 QDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGEC----ITNNMKLRHFGSSLSLPDR 403
            DI+TV NGPF   K   N  L      +P PRPG C     T NM+     ++   PD 
Sbjct: 343 SDIQTVFNGPFAH-KEGPNHQLISYQGRIPYPRPGTCPGGAFTPNMR-----TTKEFPDD 396

Query: 404 VLTFIRDHPLMDRPVFPADGHPLLVT--TDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGH 461
           V+TFIR+HPLM   ++P    PL+V   TD  Y ++   RV +  G+ Y VL+LGT+ G 
Sbjct: 397 VVTFIRNHPLMYNSIYPIHKRPLIVRIGTDYKYTKIAVDRVNAADGR-YHVLFLGTDRGT 455

Query: 462 LHRAVRIGAQLSV-----LEDLALFPEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNCG 514
           + + V +    SV     LE+L +F    P+  MK+      L V S   V+QV+   C 
Sbjct: 456 VQKVVVLPTNNSVSGELILEELEVFKNHAPITTMKISSKKQQLYVSSNEGVSQVSLHRCH 515

Query: 515 RL-QSCSECILAQDPVCAWSFRLDECVAHAGEHRGLVQDIESADVSSLCP----KEPGER 569
               +C++C LA+DP CAW           G+ R   QD+   +  + C     K     
Sbjct: 516 IYGTACADCCLARDPYCAWDGHSCSRFYPTGKRRSRRQDVRHGNPLTQCRGFNLKAYRNA 575

Query: 570 PVVFEVPVATAAHVVLPCSPSSAWASCVW 598
             + +  V       L C+P S  AS  W
Sbjct: 576 AEIVQYGVKNNT-TFLECAPKSPQASIKW 603


>gi|188497703 semaphorin 3F [Homo sapiens]
          Length = 785

 Score =  252 bits (644), Expect = 8e-67
 Identities = 206/696 (29%), Positives = 303/696 (43%), Gaps = 86/696 (12%)

Query: 22  LLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFA---VPHTYNYSVLLVDPASHTLY 78
           LL  A  S P    +P + PR  L   E  +  T      + +T +Y +LL D     +Y
Sbjct: 12  LLTGAWPSFPTQDHLP-ATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMY 70

Query: 79  VGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKED-ECHNFVQILAIANASHL 137
           VG++D + +L L      P  I W       + C   GK  + EC NFV+++   N +HL
Sbjct: 71  VGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRTHL 130

Query: 138 LTCGTFAFDPKCGVIDVSRFQQV------------------------------------- 160
             CGT A++P C  ++  R  Q                                      
Sbjct: 131 YVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQDYIFYLE 190

Query: 161 -ERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLP 219
            ERLESG+GKCP++P   +A+ +    LYA    +++GT+  I R +G+ +  +RTD   
Sbjct: 191 PERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGK-QTAMRTDQYN 249

Query: 220 S-WLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLG 278
           S WLN P+F+ A  +  +    E  DD++YFFF E S        +   R+ R+C  D G
Sbjct: 250 SRWLNDPSFIHAELIPDSA---ERNDDKLYFFFRERSAEAPQSPAV-YARIGRICLNDDG 305

Query: 279 GRKTLQQRWTTFLKADLLCPGP-EHGRAS--SVLQDVAVLRPELGAGTPIFYGIFSSQWE 335
           G   L  +W+TFLKA L+C  P E G  +    LQDV V + +     P+ Y +F+S   
Sbjct: 306 GHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQ-DVRNPVIYAVFTSSGS 364

Query: 336 GATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGEC----ITNNMKL 391
               SAVC +   DIR V NGPF   +    + +P     +P PRPG C     T +MK 
Sbjct: 365 VFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMP-FSGKMPYPRPGTCPGGTFTPSMK- 422

Query: 392 RHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAY-LRVVAHRVTSLSGKEY 450
               S+   PD V+ F+R HPLM + V+P    PL+V T   Y L  +A      +   Y
Sbjct: 423 ----STKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRY 478

Query: 451 DVLYLGTEDGHLHRAVRIGAQLSVLEDLAL-----FPEPQPVENMKL--YHSWLLVGSRT 503
           +VL+LGT+ G + + + +      LE+L L     F +P PV+ M +      L V S  
Sbjct: 479 EVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAV 538

Query: 504 EVTQVNTTNCGRL-QSCSECILAQDPVCAWSFRLDECVAHAGEHRGLVQDIESADVSSLC 562
            VT ++   C     +C++C LA+DP CAW  +       + + R   QD+   +    C
Sbjct: 539 GVTHLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQC 598

Query: 563 P--KEPGERPVVFEVPVATAAHVV-LPCSPSSAWASCVW--HQPSGVTALTPRRDGLEVV 617
                   +  V  V    A     L C P S  A+  W   +  G      R +   + 
Sbjct: 599 RGFNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDRFLR 658

Query: 618 VTPGAM---------GAYACECQEGGAAHVVAAYSL 644
              G +         G Y+C   E    HVV    L
Sbjct: 659 TEQGLLLRALQLSDRGLYSCTATENNFKHVVTRVQL 694


>gi|19718780 semaphorin 6B precursor [Homo sapiens]
          Length = 888

 Score =  234 bits (596), Expect = 3e-61
 Identities = 191/596 (32%), Positives = 272/596 (45%), Gaps = 66/596 (11%)

Query: 8   PRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLP-----------ISEADSCLTR 56
           PR  P +P      LLLL +L G   G  P   P  S+            +      LT 
Sbjct: 4   PRASPPRPA-----LLLLLLLLGGAHGLFPEEPPPLSVAPRDYLNHYPVFVGSGPGRLTP 58

Query: 57  FAVPHTYNYSVLLVDPASHTLYVGARDTIFALSL--PFSGER--PRRIDWMVPEAHRQNC 112
                  N   +L    + TL++G RD ++ + L  P S E    R++ W    +    C
Sbjct: 59  AEGADDLNIQRVL--RVNRTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVC 116

Query: 113 RKKGKKEDECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPF 172
           R KGK+E EC NFV++L + + S L  CG+ AF+P C    +   Q V    SG  +CP+
Sbjct: 117 RMKGKQEGECRNFVKVLLLRDESTLFVCGSNAFNPVCANYSIDTLQPVGDNISGMARCPY 176

Query: 173 EPAQRSAAVMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVA 232
           +P   + A+ + G+L+ ATV ++L  + +I R++G             W   P FV AV 
Sbjct: 177 DPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAV- 235

Query: 233 LSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGR-KTLQQRWTTFL 291
               EWG       +YFFF E +  F+  E++ V RVARVC  D+GG  + L+++WT+FL
Sbjct: 236 ----EWG-----SHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFL 286

Query: 292 KADLLC--PGPEHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQD 349
           KA L C  PG  H    +VLQ V  +   LG G P+   +FS+       SAVCAF    
Sbjct: 287 KARLNCSVPGDSH-FYFNVLQAVTGV-VSLG-GRPVVLAVFSTPSNSIPGSAVCAFDLTQ 343

Query: 350 IRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIR 409
           +  V  G FRE K   +   PV ++ VP+PRPG C    M+   + +S +LPD +L F++
Sbjct: 344 VAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQ---YNASSALPDDILNFVK 400

Query: 410 DHPLMDRPVFPADGHP--LLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGH-LHRAV 466
            HPLMD  V P+ GH   +L T     L  VA  V +       V++LG+E G  L   V
Sbjct: 401 THPLMDEAV-PSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFLV 459

Query: 467 RIGAQLSVLEDLALFPEP------------------QPVENMKL--YHSWLLVGSRTEVT 506
           R  A  S    L++F E                   Q + +++L      LL      V 
Sbjct: 460 RPNASTSGTSGLSVFLEEFETYRPDRCGRPGGGETGQRLLSLELDAASGGLLAAFPRCVV 519

Query: 507 QVNTTNCGRLQSC-SECILAQDPVCAWSFRLDECVAHAGEHRGLVQDIESADVSSL 561
           +V    C +   C   CI +QDP C W+          G      QD+  A  S L
Sbjct: 520 RVPVARCQQYSGCMKNCIGSQDPYCGWAPDGSCIFLSPGTRAAFEQDVSGASTSGL 575


>gi|11991660 sema domain, transmembrane domain (TM), and cytoplasmic
           domain, (semaphorin) 6A [Homo sapiens]
          Length = 1030

 Score =  231 bits (588), Expect = 3e-60
 Identities = 165/515 (32%), Positives = 248/515 (48%), Gaps = 45/515 (8%)

Query: 76  TLYVGARDTIFALSLPFSGERP----RRIDWMVPEAHRQNCRKKGKKEDECHNFVQILAI 131
           TLY+ ARD I+ + +  S        +++ W   +A    CR KGK +DECHNF+++L  
Sbjct: 67  TLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLK 126

Query: 132 ANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYAAT 191
            N   L  CGT AF+P C    +   +      SG  +CP++    + A+ A G LY+AT
Sbjct: 127 KNDDALFVCGTNAFNPSCRNYKMDTLEPFGDEFSGMARCPYDAKHANVALFADGKLYSAT 186

Query: 192 VKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGDEDGDDEIYFFF 251
           V ++L  + +I R++G +           WL  P FV AV          D  D IYFFF
Sbjct: 187 VTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQAV----------DYGDYIYFFF 236

Query: 252 TETSRAFDSYERIKVPRVARVCAGDLGG-RKTLQQRWTTFLKADLLC--PGPEHGRASSV 308
            E +  +++  ++  PRVA+VC  D+GG ++ L+++WT+FLKA L C  PG  H   + +
Sbjct: 237 REIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNIL 296

Query: 309 LQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCNRG 368
                V+R     G  +    FS+ +     SAVCA+   DI +V  G F+E K   +  
Sbjct: 297 QAVTDVIRIN---GRDVVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTW 353

Query: 369 LPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLV 428
            PV D  VP+PRPG C   +  L  + +S   PD  L FI+ HPLMD  V      P  +
Sbjct: 354 TPVPDERVPKPRPG-CCAGSSSLERYATSNEFPDDTLNFIKTHPLMDEAVPSIFNRPWFL 412

Query: 429 TTDTAYLRVVAHRVTSLSG--KEYDVLYLGTEDGHLHR-AVRIG-----AQLSVLEDLAL 480
            T   Y R+    V + +G  + + V++LG+E G + +   RIG          LE++++
Sbjct: 413 RTMVRY-RLTKIAVDTAAGPYQNHTVVFLGSEKGIILKFLARIGNSGFLNDSLFLEEMSV 471

Query: 481 F---------PEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNCGRLQSCSE-CILAQDP 528
           +          E + +  M+L    S L V   T V +V    C R   C + CI ++DP
Sbjct: 472 YNSEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDP 531

Query: 529 VCAWSFRLDECVAHAGEHRGLV--QDIESADVSSL 561
            C W      C +H   +  L   QDIE  +   L
Sbjct: 532 YCGWIKEGGAC-SHLSPNSRLTFEQDIERGNTDGL 565


>gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]
          Length = 1011

 Score =  224 bits (570), Expect = 3e-58
 Identities = 153/486 (31%), Positives = 246/486 (50%), Gaps = 47/486 (9%)

Query: 76  TLYVGARDTIFALSLPFSGERPR-------RIDWMVPEAHRQNCRKKGKKEDECHNFVQI 128
           TLY+  RD ++ ++L    E P+       ++ W   +  R+NC  KGK +DECHNF+++
Sbjct: 68  TLYIAGRDQVYTVNL---NEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKV 124

Query: 129 LAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLY 188
               N   +  CGT AF+P C    +S  +      SG  +CPF+  Q + A+ A G LY
Sbjct: 125 FVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLY 184

Query: 189 AATVKNYLGTEPIITRAVGRAEDWIRTDTLPS-WLNAPAFVAAVALSPAEWGDEDGDDEI 247
           +ATV ++L ++ +I R++G     +RT    S W+  P F+ A+     E+G     + +
Sbjct: 185 SATVADFLASDAVIYRSMGDGSA-LRTIKYDSKWIKEPHFLHAI-----EYG-----NYV 233

Query: 248 YFFFTETSRAFDSYERIKVPRVARVCAGDLGG-RKTLQQRWTTFLKADLLCPGP-EHGRA 305
           YFFF E +   ++  +    RVAR+C  D+GG ++ L++ WT+FLKA L C  P +    
Sbjct: 234 YFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFY 293

Query: 306 SSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDC 365
             VLQ +  +      G P   G+F++Q      SAVCAF   DI  V  G F+E K   
Sbjct: 294 FDVLQSITDIIQI--NGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPD 351

Query: 366 NRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHP 425
           +    V ++ VP+PRPG C  + +    + +S+  PD  L+FI+ HPLMD  V P    P
Sbjct: 352 SVWTAVPEDKVPKPRPGCCAKHGL-AEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEP 410

Query: 426 LLVTTDTAYLRVVAHRVTSLSG--KEYDVLYLGTEDGHLHRAVRIGAQLS-----VLEDL 478
               T   Y R+ A  V   +G  + Y V+++G+E G + + +   +  S     +LE++
Sbjct: 411 WFTKTRVRY-RLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEI 469

Query: 479 ALF---------PEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNCGRLQSCSE-CILAQ 526
             +          E + V +++L   H  L V   + + ++  + C R  SC + CI ++
Sbjct: 470 EAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASR 529

Query: 527 DPVCAW 532
           DP C W
Sbjct: 530 DPYCGW 535


>gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]
          Length = 597

 Score =  224 bits (570), Expect = 3e-58
 Identities = 153/486 (31%), Positives = 246/486 (50%), Gaps = 47/486 (9%)

Query: 76  TLYVGARDTIFALSLPFSGERPR-------RIDWMVPEAHRQNCRKKGKKEDECHNFVQI 128
           TLY+  RD ++ ++L    E P+       ++ W   +  R+NC  KGK +DECHNF+++
Sbjct: 68  TLYIAGRDQVYTVNL---NEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKV 124

Query: 129 LAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLY 188
               N   +  CGT AF+P C    +S  +      SG  +CPF+  Q + A+ A G LY
Sbjct: 125 FVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLY 184

Query: 189 AATVKNYLGTEPIITRAVGRAEDWIRTDTLPS-WLNAPAFVAAVALSPAEWGDEDGDDEI 247
           +ATV ++L ++ +I R++G     +RT    S W+  P F+ A+     E+G     + +
Sbjct: 185 SATVADFLASDAVIYRSMGDGSA-LRTIKYDSKWIKEPHFLHAI-----EYG-----NYV 233

Query: 248 YFFFTETSRAFDSYERIKVPRVARVCAGDLGG-RKTLQQRWTTFLKADLLCPGP-EHGRA 305
           YFFF E +   ++  +    RVAR+C  D+GG ++ L++ WT+FLKA L C  P +    
Sbjct: 234 YFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFY 293

Query: 306 SSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDC 365
             VLQ +  +      G P   G+F++Q      SAVCAF   DI  V  G F+E K   
Sbjct: 294 FDVLQSITDIIQI--NGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPD 351

Query: 366 NRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHP 425
           +    V ++ VP+PRPG C  + +    + +S+  PD  L+FI+ HPLMD  V P    P
Sbjct: 352 SVWTAVPEDKVPKPRPGCCAKHGL-AEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEP 410

Query: 426 LLVTTDTAYLRVVAHRVTSLSG--KEYDVLYLGTEDGHLHRAVRIGAQLS-----VLEDL 478
               T   Y R+ A  V   +G  + Y V+++G+E G + + +   +  S     +LE++
Sbjct: 411 WFTKTRVRY-RLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEI 469

Query: 479 ALF---------PEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNCGRLQSCSE-CILAQ 526
             +          E + V +++L   H  L V   + + ++  + C R  SC + CI ++
Sbjct: 470 EAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASR 529

Query: 527 DPVCAW 532
           DP C W
Sbjct: 530 DPYCGW 535


>gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]
          Length = 1073

 Score =  224 bits (570), Expect = 3e-58
 Identities = 153/486 (31%), Positives = 246/486 (50%), Gaps = 47/486 (9%)

Query: 76  TLYVGARDTIFALSLPFSGERPR-------RIDWMVPEAHRQNCRKKGKKEDECHNFVQI 128
           TLY+  RD ++ ++L    E P+       ++ W   +  R+NC  KGK +DECHNF+++
Sbjct: 68  TLYIAGRDQVYTVNL---NEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKV 124

Query: 129 LAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLY 188
               N   +  CGT AF+P C    +S  +      SG  +CPF+  Q + A+ A G LY
Sbjct: 125 FVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLY 184

Query: 189 AATVKNYLGTEPIITRAVGRAEDWIRTDTLPS-WLNAPAFVAAVALSPAEWGDEDGDDEI 247
           +ATV ++L ++ +I R++G     +RT    S W+  P F+ A+     E+G     + +
Sbjct: 185 SATVADFLASDAVIYRSMGDGSA-LRTIKYDSKWIKEPHFLHAI-----EYG-----NYV 233

Query: 248 YFFFTETSRAFDSYERIKVPRVARVCAGDLGG-RKTLQQRWTTFLKADLLCPGP-EHGRA 305
           YFFF E +   ++  +    RVAR+C  D+GG ++ L++ WT+FLKA L C  P +    
Sbjct: 234 YFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFY 293

Query: 306 SSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDC 365
             VLQ +  +      G P   G+F++Q      SAVCAF   DI  V  G F+E K   
Sbjct: 294 FDVLQSITDIIQI--NGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPD 351

Query: 366 NRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHP 425
           +    V ++ VP+PRPG C  + +    + +S+  PD  L+FI+ HPLMD  V P    P
Sbjct: 352 SVWTAVPEDKVPKPRPGCCAKHGL-AEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEP 410

Query: 426 LLVTTDTAYLRVVAHRVTSLSG--KEYDVLYLGTEDGHLHRAVRIGAQLS-----VLEDL 478
               T   Y R+ A  V   +G  + Y V+++G+E G + + +   +  S     +LE++
Sbjct: 411 WFTKTRVRY-RLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEI 469

Query: 479 ALF---------PEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNCGRLQSCSE-CILAQ 526
             +          E + V +++L   H  L V   + + ++  + C R  SC + CI ++
Sbjct: 470 EAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASR 529

Query: 527 DPVCAW 532
           DP C W
Sbjct: 530 DPYCGW 535


>gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]
          Length = 1017

 Score =  224 bits (570), Expect = 3e-58
 Identities = 153/486 (31%), Positives = 246/486 (50%), Gaps = 47/486 (9%)

Query: 76  TLYVGARDTIFALSLPFSGERPR-------RIDWMVPEAHRQNCRKKGKKEDECHNFVQI 128
           TLY+  RD ++ ++L    E P+       ++ W   +  R+NC  KGK +DECHNF+++
Sbjct: 68  TLYIAGRDQVYTVNL---NEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKV 124

Query: 129 LAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLY 188
               N   +  CGT AF+P C    +S  +      SG  +CPF+  Q + A+ A G LY
Sbjct: 125 FVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLY 184

Query: 189 AATVKNYLGTEPIITRAVGRAEDWIRTDTLPS-WLNAPAFVAAVALSPAEWGDEDGDDEI 247
           +ATV ++L ++ +I R++G     +RT    S W+  P F+ A+     E+G     + +
Sbjct: 185 SATVADFLASDAVIYRSMGDGSA-LRTIKYDSKWIKEPHFLHAI-----EYG-----NYV 233

Query: 248 YFFFTETSRAFDSYERIKVPRVARVCAGDLGG-RKTLQQRWTTFLKADLLCPGP-EHGRA 305
           YFFF E +   ++  +    RVAR+C  D+GG ++ L++ WT+FLKA L C  P +    
Sbjct: 234 YFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFY 293

Query: 306 SSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDC 365
             VLQ +  +      G P   G+F++Q      SAVCAF   DI  V  G F+E K   
Sbjct: 294 FDVLQSITDIIQI--NGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPD 351

Query: 366 NRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHP 425
           +    V ++ VP+PRPG C  + +    + +S+  PD  L+FI+ HPLMD  V P    P
Sbjct: 352 SVWTAVPEDKVPKPRPGCCAKHGL-AEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEP 410

Query: 426 LLVTTDTAYLRVVAHRVTSLSG--KEYDVLYLGTEDGHLHRAVRIGAQLS-----VLEDL 478
               T   Y R+ A  V   +G  + Y V+++G+E G + + +   +  S     +LE++
Sbjct: 411 WFTKTRVRY-RLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEI 469

Query: 479 ALF---------PEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNCGRLQSCSE-CILAQ 526
             +          E + V +++L   H  L V   + + ++  + C R  SC + CI ++
Sbjct: 470 EAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASR 529

Query: 527 DPVCAW 532
           DP C W
Sbjct: 530 DPYCGW 535


>gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]
          Length = 998

 Score =  224 bits (570), Expect = 3e-58
 Identities = 153/486 (31%), Positives = 246/486 (50%), Gaps = 47/486 (9%)

Query: 76  TLYVGARDTIFALSLPFSGERPR-------RIDWMVPEAHRQNCRKKGKKEDECHNFVQI 128
           TLY+  RD ++ ++L    E P+       ++ W   +  R+NC  KGK +DECHNF+++
Sbjct: 68  TLYIAGRDQVYTVNL---NEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKV 124

Query: 129 LAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLY 188
               N   +  CGT AF+P C    +S  +      SG  +CPF+  Q + A+ A G LY
Sbjct: 125 FVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLY 184

Query: 189 AATVKNYLGTEPIITRAVGRAEDWIRTDTLPS-WLNAPAFVAAVALSPAEWGDEDGDDEI 247
           +ATV ++L ++ +I R++G     +RT    S W+  P F+ A+     E+G     + +
Sbjct: 185 SATVADFLASDAVIYRSMGDGSA-LRTIKYDSKWIKEPHFLHAI-----EYG-----NYV 233

Query: 248 YFFFTETSRAFDSYERIKVPRVARVCAGDLGG-RKTLQQRWTTFLKADLLCPGP-EHGRA 305
           YFFF E +   ++  +    RVAR+C  D+GG ++ L++ WT+FLKA L C  P +    
Sbjct: 234 YFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFY 293

Query: 306 SSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDC 365
             VLQ +  +      G P   G+F++Q      SAVCAF   DI  V  G F+E K   
Sbjct: 294 FDVLQSITDIIQI--NGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPD 351

Query: 366 NRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHP 425
           +    V ++ VP+PRPG C  + +    + +S+  PD  L+FI+ HPLMD  V P    P
Sbjct: 352 SVWTAVPEDKVPKPRPGCCAKHGL-AEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEP 410

Query: 426 LLVTTDTAYLRVVAHRVTSLSG--KEYDVLYLGTEDGHLHRAVRIGAQLS-----VLEDL 478
               T   Y R+ A  V   +G  + Y V+++G+E G + + +   +  S     +LE++
Sbjct: 411 WFTKTRVRY-RLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEI 469

Query: 479 ALF---------PEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNCGRLQSCSE-CILAQ 526
             +          E + V +++L   H  L V   + + ++  + C R  SC + CI ++
Sbjct: 470 EAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASR 529

Query: 527 DPVCAW 532
           DP C W
Sbjct: 530 DPYCGW 535


>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
          Length = 1151

 Score =  216 bits (551), Expect = 5e-56
 Identities = 172/560 (30%), Positives = 251/560 (44%), Gaps = 54/560 (9%)

Query: 6   ARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSC------------ 53
           AR   GP    A P  + LL      +   +  S   +S P SE   C            
Sbjct: 51  ARTAEGPIMVLAGPLAVSLLLPSLTLLVSHLSSSQDVSSEPSSEQQLCALSKHPTVAFED 110

Query: 54  ----LTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHR 109
               ++ F  P   ++S L +DP+ + L VGAR+ +F LSL  +    +  +W   E  R
Sbjct: 111 LQPWVSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLA-NVSLLQATEWASSEDTR 169

Query: 110 QNCRKKGKKEDECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGK 169
           ++C+ KGK E+EC N+V++L +A    +  CGT AF P C    V    +     +G  +
Sbjct: 170 RSCQSKGKTEEECQNYVRVLIVAGRK-VFMCGTNAFSPMCTSRQVGNLSRTIEKINGVAR 228

Query: 170 CPFEPAQRSAAVMAG-GVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFV 228
           CP++P   S AV++  G LYAATV ++ G +P I R++G             WLN P FV
Sbjct: 229 CPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFV 288

Query: 229 AAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWT 288
           AA  +              YFF  E +   D   R    RVARVC  D+GGR  L+  WT
Sbjct: 289 AAYDIGLFA----------YFFLRENAVEHDC-GRTVYSRVARVCKNDVGGRFLLEDTWT 337

Query: 289 TFLKADLLCPGPEHGRASSVLQDV--AVLRPELGAGTPIFYGIFSSQWEGATISAVCAFR 346
           TF+KA L C  P  G       ++  A   PE      + YG+F++       SAVCAF 
Sbjct: 338 TFMKARLNCSRP--GEVPFYYNELQSAFHLPE----QDLIYGVFTTNVNSIAASAVCAFN 391

Query: 347 PQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLT 406
              I    NGPFR  ++     LP+  N +P  + G        L   G + +L +R L 
Sbjct: 392 LSAISQAFNGPFRYQENPRAAWLPIA-NPIPNFQCG-------TLPETGPNENLTERSLQ 443

Query: 407 FIRDHPLMDRPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAV 466
             +   LM   V P    P  VT D+     +   +       Y VLY+GTE G + +A+
Sbjct: 444 DAQRLFLMSEAVQPVTPEP-CVTQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKAL 502

Query: 467 RIGAQL---SVLEDLALFP--EPQPVENMKLYHS--WLLVGSRTEVTQVNTTNCGRLQSC 519
              ++      LE+L + P    +P+ ++++ HS   L VG R  V +V    C   +S 
Sbjct: 503 STASRSLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQ 562

Query: 520 SECILAQDPVCAWSFRLDEC 539
             C+ A+DP C W  +   C
Sbjct: 563 GACLGARDPYCGWDGKQQRC 582


>gi|16306552 semaphorin Y [Homo sapiens]
          Length = 930

 Score =  214 bits (545), Expect = 2e-55
 Identities = 157/495 (31%), Positives = 229/495 (46%), Gaps = 61/495 (12%)

Query: 74  SHTLYVGARDTIFALSLPFSGERP-----RRIDWMVPEAHRQNCRKKGKKEDECHNFVQI 128
           + TL V ARD +F+  L    E       + + W   +   +NC  +GK  DEC+N++++
Sbjct: 70  NRTLLVAARDHVFSFDLQAEEEGEGLVPNKYLTWRSQDV--ENCAVRGKLTDECYNYIRV 127

Query: 129 LAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLY 188
           L   ++  LL CGT +F P C    ++  QQ     SG+ +CPF+  Q + A+ A G LY
Sbjct: 128 LVPWDSQTLLACGTNSFSPVCRSYGITSLQQEGEELSGQARCPFDATQSNVAIFAEGSLY 187

Query: 189 AATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGDEDGDDEIY 248
           +AT  ++  ++ ++ R++G             WL  P FV A+          +  D +Y
Sbjct: 188 SATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVQAL----------EHGDHVY 237

Query: 249 FFFTETSRAFDSYERIKVPRVARVCAGDLGGR-KTLQQRWTTFLKADLLCPGP-EHGRAS 306
           FFF E S       R++  RVARVC  D+GG  + L + WT+FLK  L C  P +     
Sbjct: 238 FFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYF 297

Query: 307 SVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCN 366
            VLQ  A+  P    G    +G+F++Q      SAVCAF   +I     G F+E +    
Sbjct: 298 DVLQ--ALTGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDG 355

Query: 367 RGLPVVDNDVPQPRPGECI-TNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHP 425
              PV ++ VP PRPG C       L  F SS  LPD VLTFI+ HPL+D  V P    P
Sbjct: 356 AWTPVSEDRVPSPRPGSCAGVGGAAL--FSSSRDLPDDVLTFIKAHPLLDPAVPPVTHQP 413

Query: 426 LLVTTDTAYLRVVAHRVTSLSG--KEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPE 483
           LL  T  A L  VA  V  ++G      V++LG+ DG + + +  G +          PE
Sbjct: 414 LLTLTSRALLTQVA--VDGMAGPHSNITVMFLGSNDGTVLKVLTPGGRSG-------GPE 464

Query: 484 PQPVENMKLYHSWLLVGSRTEVT-------QVNT------------------TNCGRLQS 518
           P  +E +  Y      G RT  T       +++T                  + C R  +
Sbjct: 465 PILLEEIDAYSPARCSGKRTAQTARRIIGLELDTEGHRLFVAFSGCIVYLPLSRCARHGA 524

Query: 519 CS-ECILAQDPVCAW 532
           C   C+ +QDP C W
Sbjct: 525 CQRSCLASQDPYCGW 539


>gi|147904700 semaphorin 5A [Homo sapiens]
          Length = 1074

 Score =  212 bits (539), Expect = 1e-54
 Identities = 162/516 (31%), Positives = 245/516 (47%), Gaps = 48/516 (9%)

Query: 42  RTSLPI---SEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPR 98
           RT  P+    E    L  F   +  ++S L  DP    L VGAR+ +F L L       +
Sbjct: 32  RTEHPVISYKEIGPWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLE-DLSLIQ 90

Query: 99  RIDWMVPEAHRQNCRKKGKKEDECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQ 158
            ++W   EA ++ C  KGK ++EC N++++L +     L TCGT AF P C    +S   
Sbjct: 91  AVEWECDEATKKACYSKGKSKEECQNYIRVLLVGG-DRLFTCGTNAFTPVCTNRSLSNLT 149

Query: 159 QVERLESGRGKCPFEPAQRSAAVM-AGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDT 217
           ++    SG  +CP+ P   S A++ AGG LYAAT  ++ G +P I R++G          
Sbjct: 150 EIHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQY 209

Query: 218 LPSWLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDL 277
              WLN P FV++           D  +  YFFF E +   D  + +   R ARVC  D+
Sbjct: 210 NSKWLNEPNFVSSY----------DIGNFTYFFFRENAVEHDCGKTV-FSRAARVCKNDI 258

Query: 278 GGRKTLQQRWTTFLKADLLCPGP-EHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEG 336
           GGR  L+  WTTF+KA L C  P E     + LQ    L PEL     + YGIF++    
Sbjct: 259 GGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFL-PEL----DLIYGIFTTNVNS 313

Query: 337 ATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPG-ECITNNMKLRHFG 395
              SAVC F    I    +GPF+  ++  +  LP      P P P  +C T +      G
Sbjct: 314 IAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLP-----YPNPNPHFQCGTVDQ-----G 363

Query: 396 SSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKE--YDVL 453
             ++L +R L   +   LM   V P    P  +  ++ +  V    V  + G+E    ++
Sbjct: 364 LYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVA---VDVVQGREALVHII 420

Query: 454 YLGTEDGHLHRAVRI----GAQLSVLEDLALFPE--PQPVENMKLYHSW--LLVGSRTEV 505
           YL T+ G + + VR+     +   +LE++ LFPE   +P+ ++++ HS   L VG R  V
Sbjct: 421 YLATDYGTI-KKVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHV 479

Query: 506 TQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECVA 541
            ++    C   ++ S CI AQDP C W   + +C +
Sbjct: 480 VKIPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCTS 515


>gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]
          Length = 476

 Score =  210 bits (535), Expect = 4e-54
 Identities = 140/428 (32%), Positives = 219/428 (51%), Gaps = 31/428 (7%)

Query: 76  TLYVGARDTIFALSLPFSGERPR-------RIDWMVPEAHRQNCRKKGKKEDECHNFVQI 128
           TLY+  RD ++ ++L    E P+       ++ W   +  R+NC  KGK +DECHNF+++
Sbjct: 68  TLYIAGRDQVYTVNL---NEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKV 124

Query: 129 LAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLY 188
               N   +  CGT AF+P C    +S  +      SG  +CPF+  Q + A+ A G LY
Sbjct: 125 FVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLY 184

Query: 189 AATVKNYLGTEPIITRAVGRAEDWIRTDTLPS-WLNAPAFVAAVALSPAEWGDEDGDDEI 247
           +ATV ++L ++ +I R++G     +RT    S W+  P F+ A+     E+G     + +
Sbjct: 185 SATVADFLASDAVIYRSMGDGSA-LRTIKYDSKWIKEPHFLHAI-----EYG-----NYV 233

Query: 248 YFFFTETSRAFDSYERIKVPRVARVCAGDLGG-RKTLQQRWTTFLKADLLCPGP-EHGRA 305
           YFFF E +   ++  +    RVAR+C  D+GG ++ L++ WT+FLKA L C  P +    
Sbjct: 234 YFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFY 293

Query: 306 SSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDC 365
             VLQ +  +      G P   G+F++Q      SAVCAF   DI  V  G F+E K   
Sbjct: 294 FDVLQSITDIIQI--NGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPD 351

Query: 366 NRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHP 425
           +    V ++ VP+PRPG C  + +    + +S+  PD  L+FI+ HPLMD  V P    P
Sbjct: 352 SVWTAVPEDKVPKPRPGCCAKHGL-AEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEP 410

Query: 426 LLVTTDTAYLRVVAHRVTSLSG--KEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPE 483
               T   Y R+ A  V   +G  + Y V+++G+E G + + +   +  S L D  L  E
Sbjct: 411 WFTKTRVRY-RLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFS-LNDSVLLEE 468

Query: 484 PQPVENMK 491
            +   + K
Sbjct: 469 IEAYNHAK 476


>gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]
          Length = 666

 Score =  180 bits (456), Expect = 5e-45
 Identities = 192/704 (27%), Positives = 296/704 (42%), Gaps = 78/704 (11%)

Query: 4   SAARPR-PGPGQPTASPFPLLLLAVL---SGPVSGRVPRSVPRTSLPISEADSCLTRFAV 59
           SA R R PGP      P  L LL +L   +    G + RS PR    + +      R   
Sbjct: 12  SAPRARVPGPPARLGLPLRLRLLLLLWAAAASAQGHL-RSGPRI-FAVWKGHVGQDRVDF 69

Query: 60  PHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKE 119
             T  ++VL  +P S +++VG R  ++    P       R   +   + + +C  K    
Sbjct: 70  GQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEGKNASVRT--VNIGSTKGSCLDKR--- 124

Query: 120 DECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSA 179
            +C N++ +L    +  LL CGT A  P C  +       V  L   RG  PF P + S 
Sbjct: 125 -DCENYITLLE-RRSEGLLACGTNARHPSCWNLVNGT---VVPLGEMRGYAPFSPDENSL 179

Query: 180 AVMAGGVLYAATVKN-YLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEW 238
            +  G  +Y+   K  Y G  P   R  G +E +  +DT+   +  P F+ A  +     
Sbjct: 180 VLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYT-SDTV---MQNPQFIKATIVHQ--- 232

Query: 239 GDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQ-QRWTTFLKADLLC 297
            D+  DD+IY+FF E +   +    + V RVA++C GD GG  +L   +W TFLKA L+C
Sbjct: 233 -DQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVC 291

Query: 298 PGPEHGRASSVLQDVAVLRPELGAGTPI-FYGIFSSQWEGATISAVCAFRPQDIRTVLNG 356
                 +  + LQDV +L    G       YG+FS+ W     SAVC +   DI  V   
Sbjct: 292 SDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPW---NYSAVCVYSLGDIDKVFR- 347

Query: 357 PFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDR 416
                       L    + +P PRPG+C+ +            +P         HP + +
Sbjct: 348 ---------TSSLKGYHSSLPNPRPGKCLPDQQ---------PIPTETFQVADRHPEVAQ 389

Query: 417 PVFPADGHPL---LVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQ-- 471
            V P    PL   L  +   Y +V  HR+ +  G+ + VLYL T+ G +H+ V  G Q  
Sbjct: 390 RVEPMG--PLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEH 447

Query: 472 ---LSVLEDLALFPEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNCGRL-QSCSECILA 525
               +++E +  F     ++ M L      L V S+ EV+QV    C      C  C+++
Sbjct: 448 SFAFNIME-IQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMS 506

Query: 526 QDPVCAWSFRLDECVAHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPVATAAHVVL 585
           +DP C W      C++     R ++Q I  A+    CP    ++  + +V +A  +   L
Sbjct: 507 RDPYCGWD--QGRCISIYSSERSVLQSINPAEPHKECPNPKPDKAPLQKVSLAPNSRYYL 564

Query: 586 PCSPSSAWASCVW-HQPSGVTALTPRRDGLEVV-----VTPGAMGAYACECQEGGAAHVV 639
            C   S  A+  W H+ +   +  P       +     +T    G Y CE QEG      
Sbjct: 565 SCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQYGHYFCEAQEGSYFREA 624

Query: 640 AAYSLVWGSQRDAPSRAHTVG---AGLAGFFLGILAASLTLILI 680
             + L+     D     H +G   A  A  +LG+L  +LTL L+
Sbjct: 625 QHWQLL---PEDGIMAEHLLGHACALAASLWLGVL-PTLTLGLL 664


>gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens]
          Length = 652

 Score =  180 bits (456), Expect = 5e-45
 Identities = 190/704 (26%), Positives = 290/704 (41%), Gaps = 92/704 (13%)

Query: 4   SAARPR-PGPGQPTASPFPLLLLAVL---SGPVSGRVPRSVPRTSLPISEADSCLTRFAV 59
           SA R R PGP      P  L LL +L   +    G + RS PR    + +      R   
Sbjct: 12  SAPRARVPGPPARLGLPLRLRLLLLLWAAAASAQGHL-RSGPRI-FAVWKGHVGQDRVDF 69

Query: 60  PHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKE 119
             T  ++VL  +P S +++VG R  ++    P                      K     
Sbjct: 70  GQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEG--------------------KNASVR 109

Query: 120 DECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSA 179
            +C N++ +L    +  LL CGT A  P C  +       V  L   RG  PF P + S 
Sbjct: 110 TDCENYITLLE-RRSEGLLACGTNARHPSCWNLVNGT---VVPLGEMRGYAPFSPDENSL 165

Query: 180 AVMAGGVLYAATVKN-YLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEW 238
            +  G  +Y+   K  Y G  P   R  G +E +  +DT+   +  P F+ A  +     
Sbjct: 166 VLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYT-SDTV---MQNPQFIKATIVHQ--- 218

Query: 239 GDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQ-QRWTTFLKADLLC 297
            D+  DD+IY+FF E +   +    + V RVA++C GD GG  +L   +W TFLKA L+C
Sbjct: 219 -DQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVC 277

Query: 298 PGPEHGRASSVLQDVAVLRPELGAGTPI-FYGIFSSQWEGATISAVCAFRPQDIRTVLNG 356
                 +  + LQDV +L    G       YG+FS+ W     SAVC +   DI  V   
Sbjct: 278 SDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPW---NYSAVCVYSLGDIDKVFR- 333

Query: 357 PFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDR 416
                       L    + +P PRPG+C+ +            +P         HP + +
Sbjct: 334 ---------TSSLKGYHSSLPNPRPGKCLPDQQ---------PIPTETFQVADRHPEVAQ 375

Query: 417 PVFPADGHPL---LVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQ-- 471
            V P    PL   L  +   Y +V  HR+ +  G+ + VLYL T+ G +H+ V  G Q  
Sbjct: 376 RVEPMG--PLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEH 433

Query: 472 ---LSVLEDLALFPEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNCGRL-QSCSECILA 525
               +++E +  F     ++ M L      L V S+ EV+QV    C      C  C+++
Sbjct: 434 SFAFNIME-IQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMS 492

Query: 526 QDPVCAWSFRLDECVAHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPVATAAHVVL 585
           +DP C W      C++     R ++Q I  A+    CP    ++  + +V +A  +   L
Sbjct: 493 RDPYCGWD--QGRCISIYSSERSVLQSINPAEPHKECPNPKPDKAPLQKVSLAPNSRYYL 550

Query: 586 PCSPSSAWASCVW-HQPSGVTALTPRRDGLEVV-----VTPGAMGAYACECQEGGAAHVV 639
            C   S  A+  W H+ +   +  P       +     +T    G Y CE QEG      
Sbjct: 551 SCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQYGHYFCEAQEGSYFREA 610

Query: 640 AAYSLVWGSQRDAPSRAHTVG---AGLAGFFLGILAASLTLILI 680
             + L+     D     H +G   A  A  +LG+L  +LTL L+
Sbjct: 611 QHWQLL---PEDGIMAEHLLGHACALAASLWLGVL-PTLTLGLL 650


>gi|225637524 semaphorin 7A isoform 3 [Homo sapiens]
          Length = 501

 Score =  157 bits (398), Expect = 3e-38
 Identities = 149/537 (27%), Positives = 230/537 (42%), Gaps = 62/537 (11%)

Query: 167 RGKCPFEPAQRSAAVMAGGVLYAATVKN-YLGTEPIITRAVGRAEDWIRTDTLPSWLNAP 225
           RG  PF P + S  +  G  +Y+   K  Y G  P   R  G +E +  +DT+   +  P
Sbjct: 2   RGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYT-SDTV---MQNP 57

Query: 226 AFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQ- 284
            F+ A  +      D+  DD+IY+FF E +   +    + V RVA++C GD GG  +L  
Sbjct: 58  QFIKATIVHQ----DQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSV 113

Query: 285 QRWTTFLKADLLCPGPEHGRASSVLQDVAVLRPELGAGTPI-FYGIFSSQWEGATISAVC 343
            +W TFLKA L+C      +  + LQDV +L    G       YG+FS+ W     SAVC
Sbjct: 114 SKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPW---NYSAVC 170

Query: 344 AFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDR 403
            +   DI  V               L    + +P PRPG+C+ +            +P  
Sbjct: 171 VYSLGDIDKVFR----------TSSLKGYHSSLPNPRPGKCLPDQQ---------PIPTE 211

Query: 404 VLTFIRDHPLMDRPVFPADGHPL---LVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDG 460
                  HP + + V P    PL   L  +   Y +V  HR+ +  G+ + VLYL T+ G
Sbjct: 212 TFQVADRHPEVAQRVEPMG--PLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRG 269

Query: 461 HLHRAVRIGAQ-----LSVLEDLALFPEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNC 513
            +H+ V  G Q      +++E +  F     ++ M L      L V S+ EV+QV    C
Sbjct: 270 TIHKVVEPGEQEHSFAFNIME-IQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLC 328

Query: 514 GRL-QSCSECILAQDPVCAWSFRLDECVAHAGEHRGLVQDIESADVSSLCPKEPGERPVV 572
                 C  C++++DP C W      C++     R ++Q I  A+    CP    ++  +
Sbjct: 329 EVYGGGCHGCLMSRDPYCGWD--QGRCISIYSSERSVLQSINPAEPHKECPNPKPDKAPL 386

Query: 573 FEVPVATAAHVVLPCSPSSAWASCVW-HQPSGVTALTPRRDGLEVV-----VTPGAMGAY 626
            +V +A  +   L C   S  A+  W H+ +   +  P       +     +T    G Y
Sbjct: 387 QKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQYGHY 446

Query: 627 ACECQEGGAAHVVAAYSLVWGSQRDAPSRAHTVG---AGLAGFFLGILAASLTLILI 680
            CE QEG        + L+     D     H +G   A  A  +LG+L  +LTL L+
Sbjct: 447 FCEAQEGSYFREAQHWQLL---PEDGIMAEHLLGHACALAASLWLGVL-PTLTLGLL 499


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,804,838
Number of Sequences: 37866
Number of extensions: 1842184
Number of successful extensions: 5808
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 5491
Number of HSP's gapped (non-prelim): 126
length of query: 770
length of database: 18,247,518
effective HSP length: 110
effective length of query: 660
effective length of database: 14,082,258
effective search space: 9294290280
effective search space used: 9294290280
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.