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Search of human proteins with 195976782
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|195976782 Paf1/RNA polymerase II complex component [Homo
sapiens]
(710 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|195976782 Paf1/RNA polymerase II complex component [Homo sapi... 1386 0.0
gi|48255931 hepatoma-derived growth factor-related protein 2 iso... 85 3e-16
gi|14249158 hepatoma-derived growth factor-related protein 2 iso... 85 3e-16
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 81 3e-15
gi|217330641 IWS1 homolog [Homo sapiens] 80 9e-15
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 79 2e-14
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 78 2e-14
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 77 4e-14
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 77 4e-14
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 74 5e-13
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 73 8e-13
gi|148746195 trichohyalin [Homo sapiens] 73 1e-12
gi|221219020 NYD-SP11 protein [Homo sapiens] 72 1e-12
gi|4557509 cylicin 2 [Homo sapiens] 72 2e-12
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 70 5e-12
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 70 7e-12
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 70 7e-12
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 70 7e-12
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 70 7e-12
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 70 9e-12
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 69 2e-11
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 69 2e-11
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 69 2e-11
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 69 2e-11
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 68 3e-11
gi|125656165 THO complex 2 [Homo sapiens] 67 4e-11
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 67 6e-11
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 67 6e-11
gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo sapi... 67 6e-11
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 67 7e-11
>gi|195976782 Paf1/RNA polymerase II complex component [Homo
sapiens]
Length = 710
Score = 1386 bits (3587), Expect = 0.0
Identities = 710/710 (100%), Positives = 710/710 (100%)
Query: 1 MRGRLCVGRAAAAAAAVAVPLAGGQEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGS 60
MRGRLCVGRAAAAAAAVAVPLAGGQEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGS
Sbjct: 1 MRGRLCVGRAAAAAAAVAVPLAGGQEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGS 60
Query: 61 DENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKI 120
DENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKI
Sbjct: 61 DENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKI 120
Query: 121 EKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHD 180
EKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHD
Sbjct: 121 EKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHD 180
Query: 181 GYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKK 240
GYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKK
Sbjct: 181 GYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKK 240
Query: 241 KKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELL 300
KKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELL
Sbjct: 241 KKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELL 300
Query: 301 AKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELN 360
AKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELN
Sbjct: 301 AKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELN 360
Query: 361 RVRLSRHKLERWCHMPFFAKTVTGCFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGT 420
RVRLSRHKLERWCHMPFFAKTVTGCFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGT
Sbjct: 361 RVRLSRHKLERWCHMPFFAKTVTGCFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGT 420
Query: 421 RTNKGLQLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDEINKKELSIK 480
RTNKGLQLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDEINKKELSIK
Sbjct: 421 RTNKGLQLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDEINKKELSIK 480
Query: 481 EALNYKFNDQDIEEIVKEKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDKAKQIQDQLN 540
EALNYKFNDQDIEEIVKEKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDKAKQIQDQLN
Sbjct: 481 EALNYKFNDQDIEEIVKEKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDKAKQIQDQLN 540
Query: 541 ELEERAEALDRQRTKNISAISYINQRNREWNIVESEKALVAESHNMKNQQMDPFTRRQCK 600
ELEERAEALDRQRTKNISAISYINQRNREWNIVESEKALVAESHNMKNQQMDPFTRRQCK
Sbjct: 541 ELEERAEALDRQRTKNISAISYINQRNREWNIVESEKALVAESHNMKNQQMDPFTRRQCK 600
Query: 601 PTIVSNSRDPAVQAAILAQLNAKYGSGVLPDAPKEMSKGQGKDKDLNSKSASDLSEDLFK 660
PTIVSNSRDPAVQAAILAQLNAKYGSGVLPDAPKEMSKGQGKDKDLNSKSASDLSEDLFK
Sbjct: 601 PTIVSNSRDPAVQAAILAQLNAKYGSGVLPDAPKEMSKGQGKDKDLNSKSASDLSEDLFK 660
Query: 661 VHDFDVKIDLQVPSSESKALAITSKAPPAKDGAPRRSLNLEDYKKRRGLI 710
VHDFDVKIDLQVPSSESKALAITSKAPPAKDGAPRRSLNLEDYKKRRGLI
Sbjct: 661 VHDFDVKIDLQVPSSESKALAITSKAPPAKDGAPRRSLNLEDYKKRRGLI 710
>gi|48255931 hepatoma-derived growth factor-related protein 2
isoform 1 [Homo sapiens]
Length = 671
Score = 84.7 bits (208), Expect = 3e-16
Identities = 84/353 (23%), Positives = 162/353 (45%), Gaps = 23/353 (6%)
Query: 22 AGGQEGSPGGGRRGSRGTTMVKKRKG--RVVIDSDTEDSGSDENLDQEL----LSLAKRK 75
A G + RG T V R+ DSD++ S + L ++ +S++KR
Sbjct: 111 ADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRA 170
Query: 76 RSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTAS 135
R S + + P+ +SE+S S+ E T + +K A + ++G + + K A
Sbjct: 171 RKASSDLDQASVSPSEEENSESS-SESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAP 229
Query: 136 SGSSDKDSSAESSA--PEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDG---YGEDLMGDE 190
S +SD DS A+S PE ++ S S+SSSSSS SDS ++ G + L
Sbjct: 230 S-ASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPR 288
Query: 191 EDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKK 250
+ + E+ + +++ KRR E +++ + E ++++E+E+E +
Sbjct: 289 GRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRR--------ELEARRRREQEEELR 340
Query: 251 KLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSE 310
+L + QE + +ER + + + + +EL+ + E K R + + P +S+
Sbjct: 341 RLRE-QEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPP-SSSD 398
Query: 311 VYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVR 363
+ E E E KS++K SS + ++++ + P+ + + P ++ R R
Sbjct: 399 SEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTR 451
Score = 47.8 bits (112), Expect = 4e-05
Identities = 68/312 (21%), Positives = 115/312 (36%), Gaps = 66/312 (21%)
Query: 79 SEEKEPPVSQPAASSDSETSDSD---------------DEWTFGSNKNKKKGKARKIEKK 123
S + E P + PA SD++ D D D S+ +K + K
Sbjct: 100 SSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKT 159
Query: 124 GTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYG 183
+K +K A SSD D ++ VS S+ +S SSS+S+ +S D++F
Sbjct: 160 PALKMSVSKRARKASSDLDQAS---------VSPSEEENSESSSESEKTS-DQDFTP--- 206
Query: 184 EDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQ 243
E++ R +R L R KKK K + K
Sbjct: 207 ---------------------EKKAAVRAPRRGPLGGR---KKK----KAPSASDSDSKA 238
Query: 244 EEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKK 303
+ + K + + S +S + S D + K + + + K + R K
Sbjct: 239 DSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGR------KP 292
Query: 304 QPLKTSEVYSDDEEEEEDDKSSE--KSDRSSRTS--SSDEEEEKEEIPPKSQPVSLPEEL 359
+P + S D + +E D+ SE + D + R + E++EE+ + +E
Sbjct: 293 KPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKER 352
Query: 360 NRVRLSRHKLER 371
R R R + ER
Sbjct: 353 RRERADRGEAER 364
Score = 47.0 bits (110), Expect = 6e-05
Identities = 94/456 (20%), Positives = 163/456 (35%), Gaps = 103/456 (22%)
Query: 9 RAAAAAAAVAVPLAGGQE-----GSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDEN 63
+ AA A PL G ++ S + S G R S + S SD +
Sbjct: 208 KKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSD 267
Query: 64 LDQELLSLAKRK--------RSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKG 115
+ + ++ R + E P S ++ SDS+ D EW +++
Sbjct: 268 VSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRREL 327
Query: 116 KARKI---------------EKKGTMKKQANKTAS---SGSSDKDSSAESSAPEEGEVSD 157
+AR+ E+K +++A++ + SG S D E P +
Sbjct: 328 EARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRK 387
Query: 158 SDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEK-----EREQELFNRI 212
SSSDS+ +E E + + AR EK E++Q ++
Sbjct: 388 GRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKV 447
Query: 213 EKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEE----------QEKKKLTQIQE---SQ 259
E+ F + +K++ K+ +EK +K E K+ L ++E Q
Sbjct: 448 ERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQ 507
Query: 260 VTSH------------NKERRSKRD-EKLDKKSQAMEELKA------------------E 288
VTS K RR K + + ++K ++ LK+ E
Sbjct: 508 VTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGME 567
Query: 289 REKRKNRTA--ELLAKKQPLKTSE-------------------VYSDDEEEEEDDKSSEK 327
+EK + + A EL ++ P + +E S +++E E+ + SE+
Sbjct: 568 KEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEE 627
Query: 328 SDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVR 363
R SS D + E P +P S +E R R
Sbjct: 628 GPRCG--SSEDLHDSVREGPDLDRPGSDRQERERAR 661
Score = 44.3 bits (103), Expect = 4e-04
Identities = 62/299 (20%), Positives = 111/299 (37%), Gaps = 35/299 (11%)
Query: 77 SDSEEKEPPVSQPA---ASSDSETSDSDDEWTFGSNKNKK-KGKARKIEKKGTMKKQANK 132
+D K PP P + ++ D + + K+K K RK +G + Q N
Sbjct: 29 ADGAVKPPPNKYPIFFFGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGLWEIQNNP 88
Query: 133 TASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEED 192
AS + SS++S APE ++ +D + ED+E +
Sbjct: 89 HASYSAPPPVSSSDSEAPE------------ANPADGSDADEDDEDRGVMAVTAVTATAA 136
Query: 193 RARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKL 252
R+E ++ ++ + +K+K K K +K + +
Sbjct: 137 SDRMESDSDSDKSSD-------------NSGLKRKTPALKMSVSKRARKASSDLDQASVS 183
Query: 253 TQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVY 312
+E+ +S E+ S +D +KK+ + RK + A + S+
Sbjct: 184 PSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSD----SKAD 239
Query: 313 SDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLER 371
SD + E + S SS +SSSD + ++ P +P P L + R + K ER
Sbjct: 240 SDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKP--LPKPRGRKPKPER 296
Score = 37.0 bits (84), Expect = 0.063
Identities = 62/323 (19%), Positives = 112/323 (34%), Gaps = 19/323 (5%)
Query: 24 GQEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKE 83
G GS G R + RKGR + DS + L++E AK+ +S S E
Sbjct: 365 GSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTE-- 422
Query: 84 PPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDS 143
P +P + + K K + RK + +M ++ K +K
Sbjct: 423 -PARKPGQKEKRVRPEEKQQ-----AKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQ 476
Query: 144 SAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTE-K 202
S +V D ++ + + + D++ + R + +
Sbjct: 477 KLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVM 536
Query: 203 EREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTS 262
E+ E++ R++ R + + ++K K +KEK E+K EE + +
Sbjct: 537 EKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEE---------LAGEEAPQ 587
Query: 263 HNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDD 322
E + D +A + K E + K +++ P S D E D
Sbjct: 588 EKAEDKPSTDLSAPVNGEATSQ-KGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPD 646
Query: 323 KSSEKSDRSSRTSSSDEEEEKEE 345
SDR R + + E +E
Sbjct: 647 LDRPGSDRQERERARGDSEALDE 669
>gi|14249158 hepatoma-derived growth factor-related protein 2
isoform 2 [Homo sapiens]
Length = 670
Score = 84.7 bits (208), Expect = 3e-16
Identities = 84/353 (23%), Positives = 162/353 (45%), Gaps = 23/353 (6%)
Query: 22 AGGQEGSPGGGRRGSRGTTMVKKRKG--RVVIDSDTEDSGSDENLDQEL----LSLAKRK 75
A G + RG T V R+ DSD++ S + L ++ +S++KR
Sbjct: 111 ADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRA 170
Query: 76 RSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTAS 135
R S + + P+ +SE+S S+ E T + +K A + ++G + + K A
Sbjct: 171 RKASSDLDQASVSPSEEENSESS-SESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAP 229
Query: 136 SGSSDKDSSAESSA--PEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDG---YGEDLMGDE 190
S +SD DS A+S PE ++ S S+SSSSSS SDS ++ G + L
Sbjct: 230 S-ASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPR 288
Query: 191 EDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKK 250
+ + E+ + +++ KRR E +++ + E ++++E+E+E +
Sbjct: 289 GRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRR--------ELEARRRREQEEELR 340
Query: 251 KLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSE 310
+L + QE + +ER + + + + +EL+ + E K R + + P +S+
Sbjct: 341 RLRE-QEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPP-SSSD 398
Query: 311 VYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVR 363
+ E E E KS++K SS + ++++ + P+ + + P ++ R R
Sbjct: 399 SEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTR 451
Score = 47.8 bits (112), Expect = 4e-05
Identities = 68/312 (21%), Positives = 115/312 (36%), Gaps = 66/312 (21%)
Query: 79 SEEKEPPVSQPAASSDSETSDSD---------------DEWTFGSNKNKKKGKARKIEKK 123
S + E P + PA SD++ D D D S+ +K + K
Sbjct: 100 SSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKT 159
Query: 124 GTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYG 183
+K +K A SSD D ++ VS S+ +S SSS+S+ +S D++F
Sbjct: 160 PALKMSVSKRARKASSDLDQAS---------VSPSEEENSESSSESEKTS-DQDFTP--- 206
Query: 184 EDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQ 243
E++ R +R L R KKK K + K
Sbjct: 207 ---------------------EKKAAVRAPRRGPLGGR---KKK----KAPSASDSDSKA 238
Query: 244 EEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKK 303
+ + K + + S +S + S D + K + + + K + R K
Sbjct: 239 DSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGR------KP 292
Query: 304 QPLKTSEVYSDDEEEEEDDKSSE--KSDRSSRTS--SSDEEEEKEEIPPKSQPVSLPEEL 359
+P + S D + +E D+ SE + D + R + E++EE+ + +E
Sbjct: 293 KPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKER 352
Query: 360 NRVRLSRHKLER 371
R R R + ER
Sbjct: 353 RRERADRGEAER 364
Score = 47.8 bits (112), Expect = 4e-05
Identities = 93/453 (20%), Positives = 163/453 (35%), Gaps = 98/453 (21%)
Query: 9 RAAAAAAAVAVPLAGGQE-----GSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDEN 63
+ AA A PL G ++ S + S G R S + S SD +
Sbjct: 208 KKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSD 267
Query: 64 LDQELLSLAKRK--------RSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKG 115
+ + ++ R + E P S ++ SDS+ D EW +++
Sbjct: 268 VSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRREL 327
Query: 116 KARKI---------------EKKGTMKKQANKTAS---SGSSDKDSSAESSAPEEGEVSD 157
+AR+ E+K +++A++ + SG S D E P +
Sbjct: 328 EARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRK 387
Query: 158 SDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEK-----EREQELFNRI 212
SSSDS+ +E E + + AR EK E++Q ++
Sbjct: 388 GRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKV 447
Query: 213 EKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEE----------QEKKKLTQIQE---SQ 259
E+ F + +K++ K+ +EK +K E K+ L ++E Q
Sbjct: 448 ERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQ 507
Query: 260 VTSH------------NKERRSKRD-EKLDKKSQAMEELKA------------------E 288
VTS K RR K + + ++K ++ LK+ E
Sbjct: 508 VTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGME 567
Query: 289 REKRKNRTA--ELLAKKQPLKTSE-------------VYSDDEEEEEDDKSSEK---SDR 330
+EK + + A EL ++ P + +E + + E +DK E+ S+
Sbjct: 568 KEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEE 627
Query: 331 SSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVR 363
R SS++ + E P +P S +E R R
Sbjct: 628 GPRCGSSEDLHDVREGPDLDRPGSDRQERERAR 660
Score = 44.3 bits (103), Expect = 4e-04
Identities = 62/299 (20%), Positives = 111/299 (37%), Gaps = 35/299 (11%)
Query: 77 SDSEEKEPPVSQPA---ASSDSETSDSDDEWTFGSNKNKK-KGKARKIEKKGTMKKQANK 132
+D K PP P + ++ D + + K+K K RK +G + Q N
Sbjct: 29 ADGAVKPPPNKYPIFFFGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGLWEIQNNP 88
Query: 133 TASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEED 192
AS + SS++S APE ++ +D + ED+E +
Sbjct: 89 HASYSAPPPVSSSDSEAPE------------ANPADGSDADEDDEDRGVMAVTAVTATAA 136
Query: 193 RARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKL 252
R+E ++ ++ + +K+K K K +K + +
Sbjct: 137 SDRMESDSDSDKSSD-------------NSGLKRKTPALKMSVSKRARKASSDLDQASVS 183
Query: 253 TQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVY 312
+E+ +S E+ S +D +KK+ + RK + A + S+
Sbjct: 184 PSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSD----SKAD 239
Query: 313 SDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLER 371
SD + E + S SS +SSSD + ++ P +P P L + R + K ER
Sbjct: 240 SDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKP--LPKPRGRKPKPER 296
Score = 38.9 bits (89), Expect = 0.017
Identities = 64/315 (20%), Positives = 117/315 (37%), Gaps = 15/315 (4%)
Query: 24 GQEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKE 83
G GS G R + RKGR + DS + L++E AK+ +S S E
Sbjct: 365 GSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTE-- 422
Query: 84 PPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDS 143
P +P + + K K + RK + +M ++ K +K
Sbjct: 423 -PARKPGQKEKRVRPEEKQQ-----AKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQ 476
Query: 144 SAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTE-K 202
S +V D ++ + + + D++ + R + +
Sbjct: 477 KLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVM 536
Query: 203 EREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQE----EEQEKKKLTQIQES 258
E+ E++ R++ R + + ++K K +KEK E+K E EE ++K +
Sbjct: 537 EKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPST 596
Query: 259 QVTSH-NKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEE 317
+++ N E S++ E + K E +E R + +L ++ SD +E
Sbjct: 597 DLSAPVNGEATSQKGESAEDKEHE-EGRDSEEGPRCGSSEDLHDVREGPDLDRPGSDRQE 655
Query: 318 EEEDDKSSEKSDRSS 332
E SE D S
Sbjct: 656 RERARGDSEALDEES 670
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 81.3 bits (199), Expect = 3e-15
Identities = 79/323 (24%), Positives = 144/323 (44%), Gaps = 29/323 (8%)
Query: 55 TEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKK 114
+ D+ S+++ D + S +K ++K+ V + S+D+E+ DS DE + K K
Sbjct: 295 SSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDE---RKDTKKDK 351
Query: 115 GKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDS---DSNSSSSSSDSDS 171
K +K +KK KK T + KD+ +S ++ +D D+ + S+DS+S
Sbjct: 352 KKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSES 411
Query: 172 SSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTA 231
E +E +D + D + + E+ + + K + K + + KK K +
Sbjct: 412 ELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDAD---SEPKGDSKKGKKDEKKGKKDS 468
Query: 232 KKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERR-SKRDEKLDKKSQAMEELKAERE 290
KK +KK+ KK E E + ++++ + H+KE++ SK+D K D + E AE +
Sbjct: 469 KKDDKKKDAKKNAESTEMESDLELKKDK--KHSKEKKGSKKDIKKDARKDT-ESTDAEFD 525
Query: 291 KRKNRTAELLAKKQPLKTS-EVYSDDEEEEED------DKSSEKSDRSSRTSSSDEEEEK 343
+ + K KTS ++ D E EE K ++SD +S S + E K
Sbjct: 526 E---------SSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESK 576
Query: 344 EEIPPKSQPVSLPEELNRVRLSR 366
S+ + E+ + R
Sbjct: 577 RGFRMSSKKTTFNEKGEKASTGR 599
Score = 68.6 bits (166), Expect = 2e-11
Identities = 71/337 (21%), Positives = 142/337 (42%), Gaps = 25/337 (7%)
Query: 42 VKK--RKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSD 99
VKK +K V D+++ D+ S ++ D+ + +K+ ++K+ + S+D+E+ D
Sbjct: 317 VKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGD 376
Query: 100 SDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSD 159
+ D N ++ KA K + K KK A K S +D +S ES ++ E D
Sbjct: 377 AKD----ARNDSRNLKKASKNDDK---KKDAKKITFS--TDSESELESKESQKDEKKD-- 425
Query: 160 SNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLK 219
S + + S DEE D E GD + + E+ +K+ +++ + K+
Sbjct: 426 -KKDSKTDNKKSVKNDEESTDADSEP-KGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAES 483
Query: 220 RRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKS 279
E +LK KK K++K K++ +++ +K T+ +++ +K + +
Sbjct: 484 TEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDT 543
Query: 280 QAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDE 339
++ E L K+K ++ + + E E + S + + + E
Sbjct: 544 ESEESLYKPGAKKKIDESDGTSANSKM----------EGLESKRGFRMSSKKTTFNEKGE 593
Query: 340 EEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMP 376
+ +PP + LP + + + WC MP
Sbjct: 594 KASTGRVPPSREKPPLPACEPSLPSPKVRRLCWCKMP 630
Score = 64.3 bits (155), Expect = 4e-10
Identities = 71/314 (22%), Positives = 135/314 (42%), Gaps = 44/314 (14%)
Query: 54 DTEDSGSDENLDQELLSLAKRKRSD---SEEKEPPVSQPAASSDSETS------DSDDE- 103
D +DS + + + E L + D S+ P+S+ + + SDDE
Sbjct: 199 DKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDES 258
Query: 104 -----WTFGSNKNKKKGKARKIEK--KGTMKKQANKTASSGSSD-KDSSAESSAPEEGEV 155
W ++N K + K K K KK A K++ + S D KD+ +S ++
Sbjct: 259 INFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVK 318
Query: 156 SDS---DSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRI 212
D D + S+D++S +E D ++D+ +L++ +K+++ + +
Sbjct: 319 KDDKKKDVKKDTESTDAESGDSKDERKD--------TKKDKKKLKK-DDKKKDTKKYPES 369
Query: 213 EKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRD 272
E + + + + KK K + KKK + KK+T +S+ +KE S++D
Sbjct: 370 TDTESGDAK-DARNDSRNLKKASKNDDKKK-----DAKKITFSTDSESELESKE--SQKD 421
Query: 273 EKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDD--KSSEKSDR 330
EK DKK + K+ + ++ A+ +P S+ DE++ + D K +K D
Sbjct: 422 EKKDKKDSKTDNKKSVKNDEESTDAD----SEPKGDSKKGKKDEKKGKKDSKKDDKKKDA 477
Query: 331 SSRTSSSDEEEEKE 344
S++ E + E
Sbjct: 478 KKNAESTEMESDLE 491
Score = 48.1 bits (113), Expect = 3e-05
Identities = 53/299 (17%), Positives = 116/299 (38%), Gaps = 31/299 (10%)
Query: 69 LSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKK 128
L A+ K+S E+ P+ + + + + + K K++ +A K K + +
Sbjct: 110 LKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHEN 169
Query: 129 QANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFH--DGYGEDL 186
+ +K + S S S S VS + S S + + E H + +DL
Sbjct: 170 EQSKKSKSSSETNPESQNSKT-----VSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDL 224
Query: 187 MGDEEDRARLEQM-TEKEREQELFNRIEKREVLKRRFEI------------------KKK 227
+ + ++ +E + + + + F+ K
Sbjct: 225 KRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYT 284
Query: 228 LKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRD-EKLDKKSQAMEELK 286
K KK KK + E+ ++ KK ++ + V +K++ K+D E D +S ++ +
Sbjct: 285 KKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDER 344
Query: 287 AEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEE 345
+ +K K + L K K ++ Y + + E D ++D + +S +++K++
Sbjct: 345 KDTKKDKKK----LKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKD 399
Score = 36.2 bits (82), Expect = 0.11
Identities = 29/148 (19%), Positives = 69/148 (46%), Gaps = 3/148 (2%)
Query: 208 LFNRIEKREVLKRRFEIKKKLKTAK-KKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKE 266
++ ++ + + K LK A+ KK K EK ++ KKK + + E
Sbjct: 90 IYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVE 149
Query: 267 RRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSE 326
++KR + D K+ + E+ K+ ++E + Q KT + +++++D K+S+
Sbjct: 150 EKTKRQNEAD-KTPLKSSHENEQSKKSKSSSETNPESQNSKTVS-KNCSQKDKKDSKNSK 207
Query: 327 KSDRSSRTSSSDEEEEKEEIPPKSQPVS 354
K++ + ++ +++ + + P+S
Sbjct: 208 KTNTEFLHTKNNPKKDLKRSKTSNDPIS 235
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 79.7 bits (195), Expect = 9e-15
Identities = 77/315 (24%), Positives = 139/315 (44%), Gaps = 39/315 (12%)
Query: 52 DSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSE-----TSDSDDEW-- 104
DS+TED+ + D E + + SDSE +EPP + + S E SDS+ E
Sbjct: 171 DSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPP 230
Query: 105 ----TFGSNKNKKKGKARKIEKKGTMKKQANKTASSG-SSDKDSSAESSAPEEGEVSDSD 159
+ N+ K + E + + QA+ + + + S +ES P + SDS+
Sbjct: 231 RHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSE 290
Query: 160 SNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLK 219
+ SDS SE + G D + ED +R +Q E + + + N+ E E+
Sbjct: 291 NEELPKPRVSDSESEGPQ--KGPASD--SETEDASRHKQKPESDDDSDRENKGEDTEMQN 346
Query: 220 RRFEI-----KKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEK 274
F +KK ++ +E++ KK+K + ++++K+ +E+ +KR
Sbjct: 347 DSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKE-----------GEEEKVAKRKAA 395
Query: 275 LDKKSQAMEELKAEREK----RKNRTAELLAKKQPLKTSEVYSDDEEE---EEDDKSSEK 327
+ S+ E+ A++ + + ++ ++ K + + SD EEE E DK +E+
Sbjct: 396 VLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEE 455
Query: 328 SDRSSRTSSSDEEEE 342
D S S EEE
Sbjct: 456 KDLFGSDSESGNEEE 470
Score = 68.9 bits (167), Expect = 2e-11
Identities = 72/312 (23%), Positives = 133/312 (42%), Gaps = 40/312 (12%)
Query: 50 VIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAAS----------SDSETSD 99
V DS++E+ + D E L K + SDSE ++PP Q + S SDSE+ D
Sbjct: 221 VSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESED 280
Query: 100 SD-DEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSD- 157
++ + N+ K + E +G K A S S +D+S PE + SD
Sbjct: 281 PPRNQASDSENEELPKPRVSDSESEGPQKGPA-----SDSETEDASRHKQKPESDDDSDR 335
Query: 158 ----SDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIE 213
D+ + S SDS + ++FH EE+ + ++M E E+E E
Sbjct: 336 ENKGEDTEMQNDSFHSDSHMDRKKFHSS------DSEEEEHKKQKMDSDEDEKE----GE 385
Query: 214 KREVLKRRFEI----KKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRS 269
+ +V KR+ + + + K + KK + + + +E + S ++E
Sbjct: 386 EEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAG 445
Query: 270 KRDEKLDKKSQAMEELKAERE---KRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSE 326
K E DKK++ + ++ E + +N A++ + + E ++E+ E++K
Sbjct: 446 K--ELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGET 503
Query: 327 KSDRSSRTSSSD 338
+ + + S D
Sbjct: 504 QVKEAEDSDSDD 515
Score = 66.2 bits (160), Expect = 1e-10
Identities = 76/361 (21%), Positives = 140/361 (38%), Gaps = 50/361 (13%)
Query: 46 KGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSET-----SDS 100
KG V DS+ ++ + D E L ++K SDSE +E PA+ S++E SDS
Sbjct: 62 KGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEER-AEPPASDSENEDVNQHGSDS 120
Query: 101 DDEWTF------GSNKNKKKGKARKIEKKGTMKKQAN--------KTASSGSSDKD---- 142
+ E T N+ G A E + K A+ K+ +S S +D
Sbjct: 121 ESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKP 180
Query: 143 ---------------SSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLM 187
S +E+ P + +SDS+S SDS SE+ H D
Sbjct: 181 QISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQA--SDSE 238
Query: 188 GDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQ 247
+E + R+ ++ + + E E+ K R E ++ + Q +
Sbjct: 239 NEELPKPRISDSESEDPPRHQASDSENEELPKPRIS---------DSESEDPPRNQASDS 289
Query: 248 EKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLK 307
E ++L + + S S ++ D + + S+ ++ +++ + + E +
Sbjct: 290 ENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSF 349
Query: 308 TSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRH 367
S+ + D ++ D E+ + S DE+E +EE K + L + + + S
Sbjct: 350 HSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAK 409
Query: 368 K 368
K
Sbjct: 410 K 410
Score = 63.9 bits (154), Expect = 5e-10
Identities = 70/317 (22%), Positives = 124/317 (39%), Gaps = 50/317 (15%)
Query: 52 DSDTEDSGSDENLDQELLSLAKRKRSDSEEKE---PPVSQPAASSDSETSDSDDEWTFGS 108
DS+ ED G D E+ L K SDSE ++ P +S + SD E
Sbjct: 145 DSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSE----- 199
Query: 109 NKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSD 168
N+ K + E + K Q S +ES P + SDS++
Sbjct: 200 NEEPPKPRMSDSESEELPKPQV------------SDSESEEPPRHQASDSENEELPKPRI 247
Query: 169 SDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKK-- 226
SDS SED H D +E + R+ ++ + + E E+ K R +
Sbjct: 248 SDSESEDPPRHQA--SDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESE 305
Query: 227 ----------KLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHN----KERRSKRD 272
+ + A + ++K + + + K + T++Q S + K+ S
Sbjct: 306 GPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDS 365
Query: 273 EKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEK----S 328
E+ + K Q M+ + E+E + + A+ + + V SD E+EE+ + +
Sbjct: 366 EEEEHKKQKMDSDEDEKEGEEEKVAK--------RKAAVLSDSEDEEKASAKKSRVVSDA 417
Query: 329 DRSSRTSSSDEEEEKEE 345
D S + SD+ ++E+
Sbjct: 418 DDSDSDAVSDKSGKREK 434
Score = 52.8 bits (125), Expect = 1e-06
Identities = 55/302 (18%), Positives = 124/302 (41%), Gaps = 24/302 (7%)
Query: 53 SDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNK 112
SD ED ++++ + S+ + +++ ++E + + +DSE + N N
Sbjct: 27 SDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEP-------LNLNA 79
Query: 113 KKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSS 172
++ ++ ++ ++ + A +SD ++ E+ SDS S + S
Sbjct: 80 SDSESEELHRQKDSDSESEERAEPPASDSEN-------EDVNQHGSDSESEETRKLPGSD 132
Query: 173 SEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAK 232
SE+EE +G+ D ++ + +E ++ + E + LK + +
Sbjct: 133 SENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQI-------SDS 185
Query: 233 KKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKR 292
+ E+ + + + E E+ ++ +S+ K + S + + + QA + E K
Sbjct: 186 ESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKP 245
Query: 293 KNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQP 352
+ +E + P + S++EE + S +S+ R +SD E E+ P S
Sbjct: 246 RISDSE---SEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDS 302
Query: 353 VS 354
S
Sbjct: 303 ES 304
Score = 48.9 bits (115), Expect = 2e-05
Identities = 65/307 (21%), Positives = 122/307 (39%), Gaps = 23/307 (7%)
Query: 76 RSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTAS 135
+SD P + + SD E ++ + ++ + +++ + K + T S
Sbjct: 10 QSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDS 69
Query: 136 SGSSDKDSSAESSAPEE-GEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRA 194
+ +A S EE DSDS S + S SE+E+ + +G D E +
Sbjct: 70 ENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQ-HGSD---SESEET 125
Query: 195 RLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQ 254
R ++ E E+ L E ++ K + + E+ +K + E E Q
Sbjct: 126 RKLPGSDSENEELLNGHASDSE----NEDVGKHPASDSEIEELQKSPASDSETEDALKPQ 181
Query: 255 IQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSD 314
I +S+ + + S + + K + + E K + +E ++P + S+
Sbjct: 182 ISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSE---SEEPPRHQASDSE 238
Query: 315 DEEEEEDDKSSEKSDRSSRTSSSDEEEE----------KEEIPPKSQPV-SLPEELNRVR 363
+EE + S +S+ R +SD E E + E PP++Q S EEL + R
Sbjct: 239 NEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPR 298
Query: 364 LSRHKLE 370
+S + E
Sbjct: 299 VSDSESE 305
Score = 33.9 bits (76), Expect = 0.54
Identities = 29/128 (22%), Positives = 54/128 (42%), Gaps = 15/128 (11%)
Query: 43 KKRKGRVVIDSDTEDSGSDENL---------DQELLSLAKRKRSDSEEKEPPVSQPAASS 93
KK + + + SD+E +ENL D+E + D EE++
Sbjct: 451 KKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQV----K 506
Query: 94 DSETSDSDDEWTFGSNKNKKKGKARKIEKKGTM--KKQANKTASSGSSDKDSSAESSAPE 151
++E SDSDD G + + +++K +M K++ N+ + SD D + +
Sbjct: 507 EAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVK 566
Query: 152 EGEVSDSD 159
E ++ D
Sbjct: 567 MNEAAEED 574
Score = 32.0 bits (71), Expect = 2.0
Identities = 34/154 (22%), Positives = 58/154 (37%), Gaps = 35/154 (22%)
Query: 42 VKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSD 101
V KRK V+ SD+ED E++ + SD++ SDSD
Sbjct: 389 VAKRKAAVL--SDSED-----------------------EEKASAKKSRVVSDADDSDSD 423
Query: 102 DEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKD---SSAESSAPEEGEVSDS 158
+ K GK K + ++ + + + +KD S +ES EE ++D
Sbjct: 424 -------AVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADI 476
Query: 159 DSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEED 192
S + + E+ + GE + + ED
Sbjct: 477 FGESGDEEEEEFTGFNQEDLEEEKGETQVKEAED 510
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 78.6 bits (192), Expect = 2e-14
Identities = 76/342 (22%), Positives = 150/342 (43%), Gaps = 32/342 (9%)
Query: 43 KKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDD 102
+K KG+ + +D D+ L +EL L+ + ++E +P +++ E + D
Sbjct: 38 QKSKGKKKKEKKKQDFDEDDIL-KELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDK 96
Query: 103 EWTFGSNKNKKKGK--------ARKIEKKGTMKKQANKTAS---SGSSDKDSSAESSAPE 151
+ K +KGK + ++E K + K+ K SGS D D +
Sbjct: 97 K------KKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKA 150
Query: 152 EGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFN- 210
+G+ S+ S D D+S + +E GDE D + +K+ ++
Sbjct: 151 KGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGP 210
Query: 211 RIEK-REVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRS 269
IE E F+IK + +K+++E+KK+ EE+ + +KL + +E +
Sbjct: 211 NIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELET--------G 262
Query: 270 KRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSD 329
K+D+ K+SQ E + + K T + A ++ +T DD E ++ K +K
Sbjct: 263 KKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKK- 321
Query: 330 RSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLER 371
+ ++E+EK++ P K+ ++ E L +++ + +R
Sbjct: 322 ---KGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKR 360
Score = 75.9 bits (185), Expect = 1e-13
Identities = 78/334 (23%), Positives = 148/334 (44%), Gaps = 37/334 (11%)
Query: 43 KKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDD 102
KK K R I+S SG + E L K ++ + + K P + E+ + DD
Sbjct: 172 KKIKERSRINS----SGESGDESDEFLQSRKGQKKNQKNKPGP--------NIESGNEDD 219
Query: 103 EWTF-----GSNKNKKKGKARKI--EKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEV 155
+ +F K +KK + RK E+K ++K K + KD S + + + E
Sbjct: 220 DASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELE-TGKKDQSKQKESQRKFEE 278
Query: 156 SDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKR 215
S + + +S E E +D GD++ + + ++ EKE +++ + +
Sbjct: 279 ETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSK 338
Query: 216 EVLKRRFEIKKKLKTAKKKEKKEKK---KKQEEEQEKKKLTQIQESQVTSHNKERRSKRD 272
+K E KLK ++++K+E++ K+ EE + K+K + E + K++ +R
Sbjct: 339 ATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERK 398
Query: 273 EKLDKKSQAMEELKAEREKRKNRTAELL--------AKKQPLKTSEVYSDDEEEE--EDD 322
E+L K+ + + + + E R T +LL +K K +Y D + ++ +
Sbjct: 399 ERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQL 458
Query: 323 KSSEKSDRSSRTSSSDEEE----EKEEIPPKSQP 352
+S E S+ ++ + E EKEE PP +P
Sbjct: 459 ESKEVSESMELCAAVEVMEQGVPEKEETPPPVEP 492
Score = 73.6 bits (179), Expect = 6e-13
Identities = 75/358 (20%), Positives = 152/358 (42%), Gaps = 35/358 (9%)
Query: 32 GRRGSRGTTMVKKRKGRVVIDSDTE----DSGSDENLDQELLSLAKRKRSDSEEKEPPVS 87
G G ++ RKG+ + +SG++++ + +K+++ +E+E
Sbjct: 184 GESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKR 243
Query: 88 QPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAES 147
+ + + ++ T +++K+K RK E++ K T +S++ + +
Sbjct: 244 DEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPT 303
Query: 148 SAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQE 207
+A ++ E D E E+ + +E A+L++ E+++ +E
Sbjct: 304 AAEDDNE-GDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREE 362
Query: 208 LFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKK----------------- 250
RI++ E L+ + + +++L+ K++ KK+K+K+++E +K+
Sbjct: 363 E-ERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEA 421
Query: 251 --KLTQIQESQVTSHN---KERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQP 305
KL Q Q +V S + K+R D+K K Q +E + E++ + P
Sbjct: 422 TLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVP 481
Query: 306 LKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEE-----IPPKSQPVSLPEE 358
K + EEEED + + D + +SDEE EK E I K P EE
Sbjct: 482 EKEETPPPVEPEEEEDTEDAGLDDWEA--MASDEETEKVEGNKVHIEVKENPEEEEEE 537
Score = 72.8 bits (177), Expect = 1e-12
Identities = 96/397 (24%), Positives = 170/397 (42%), Gaps = 90/397 (22%)
Query: 52 DSDTEDSGSDENLDQELLSLAKRKR-----------SDSEEKEPPVSQPAASSDSET--- 97
D +T EN ++E S K+K+ +DSEE E S+ ++ +
Sbjct: 75 DRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMY 134
Query: 98 SDSDDEWTFGSNKNKKKGKARKIEKK----------GTMKKQANKTASSGSSDKDSSAES 147
S SDD+ F K KGKA+K KK K+ ++ SSG S D S E
Sbjct: 135 SGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESG-DESDEF 193
Query: 148 SAPEEGEVSDSDS----NSSSSSSDSDSSSEDEEFHDGYGEDLMGD----EEDRARLEQM 199
+G+ + + N S + D D+S + + E + +E++A+L ++
Sbjct: 194 LQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKL 253
Query: 200 TEKEREQELFNRIEKREVLKRRFE---IKKKLKT-----------------------AKK 233
EKE + K++ +R+FE +K K+ K
Sbjct: 254 KEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDK 313
Query: 234 KEKKEKKK---KQEEEQEKKK------LTQIQESQVTSHNKERRSKRDEKLDKKSQAMEE 284
K+K +KKK K+E+E+EKKK + +QE+ +E R KR+E +++ + +EE
Sbjct: 314 KKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREE--EERIKRLEE 371
Query: 285 LKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDE----E 340
L+A+R++ + L +K+ K + E +++ K KS R +R + +
Sbjct: 372 LEAKRKEEE----RLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQ 427
Query: 341 EEKEEIP-----PKSQPV-------SLPEELNRVRLS 365
+ E+P PK +P+ +P++L +S
Sbjct: 428 AQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVS 464
Score = 50.1 bits (118), Expect = 7e-06
Identities = 81/375 (21%), Positives = 150/375 (40%), Gaps = 37/375 (9%)
Query: 202 KEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVT 261
KE+E + +K+E K+ F+ LK ++ + + K + E K T+ E + T
Sbjct: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
Query: 262 SHNKERRSKRDEKL---DKKSQAMEELKAEREKRKNRTAEL------------LAKKQPL 306
S +K+++ ++ +K D S+ +E+ ++ +K E+ L KK
Sbjct: 93 SKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKG 152
Query: 307 KTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSR 366
K + + EED+ +S+K SR +SS E ++ + +S+ + N+ +
Sbjct: 153 KAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNI 212
Query: 367 HKLERWCHMPFFAKTVTGCFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGTRTNKGL 426
F KTV K R + K+ + T K
Sbjct: 213 ESGNEDDDASFKIKTVAQ-------KKAEKKERERKKRDEEKAKLRKLKEKEELETGKKD 265
Query: 427 QLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDEINKKELSIKEALNYK 486
Q + QR F E V ++ ++ + E +E +KK+ K+ K
Sbjct: 266 QSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEK 325
Query: 487 FNDQDIEEIVKEKERFRKAPPNYAMKKTQ----LLKEKAMAEDLGDQDKAKQIQ--DQLN 540
EE KEKE+ +K P +K Q LKE+ + ++++ K+++ +
Sbjct: 326 ------EE--KEKEK-KKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKR 376
Query: 541 ELEERAEALDRQRTK 555
+ EER E R+R K
Sbjct: 377 KEEERLEQEKRERKK 391
Score = 45.1 bits (105), Expect = 2e-04
Identities = 81/432 (18%), Positives = 172/432 (39%), Gaps = 49/432 (11%)
Query: 236 KKEKKKKQEEEQEKKKL----TQIQESQVTSHNKERRSKRDEKLDKKSQAMEE--LKAER 289
KK+K K ++ ++ L +I+ + + ++SK +K +KK Q +E + E
Sbjct: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62
Query: 290 EKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPK 349
E+ + A ++ + +++EE DK + ++ ++ EE E+ K
Sbjct: 63 EELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSK 122
Query: 350 SQPVSLPEELNRVRLSRHKLERWCHMPFFAKTVTGCFVRIGIGNH----NSKPVYRVAEI 405
S+ + P+ + + + +P AK + G+ NSK + + I
Sbjct: 123 SKKTAKPKV--EMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRI 180
Query: 406 TGVVET---------AKVYQLGGTRTNKGLQLRHGN--DQRVFRLEFVSNQEFTESEFMK 454
E+ ++ Q + G + GN D F+++ V+ ++ + E +
Sbjct: 181 NSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERER 240
Query: 455 WKEAMFSAGM-QLPTLDEI--NKKELSIKEALNYKFNDQDIEE-------IVKEKERFRK 504
K A + +L +E+ KK+ S ++ KF ++ ++ ++ E +
Sbjct: 241 KKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAE 300
Query: 505 AP-----PNYAMKKTQLLKEKAMAEDLGDQDK--------AKQIQDQLNELEERAEALDR 551
P N KK + K+K ++ +++K K +Q+ L +L+E E R
Sbjct: 301 TPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKR 360
Query: 552 QRTKNISAISYINQRNREWNIVESEKALVAESHNMKNQQMDPFTRRQCKPTIVSNSRDPA 611
+ + I + + + +E +E EK E K ++ +++ K S A
Sbjct: 361 EEEERIKRLEELEAKRKEEERLEQEK---RERKKQKEKERKERLKKEGKLLTKSQREARA 417
Query: 612 VQAAILAQLNAK 623
A L L A+
Sbjct: 418 RAEATLKLLQAQ 429
Score = 40.8 bits (94), Expect = 0.004
Identities = 52/322 (16%), Positives = 125/322 (38%), Gaps = 35/322 (10%)
Query: 53 SDTEDSGSDENLDQELLSLAKRKRSDSEEKE------PPVSQPAASSDSETSDSDDEWTF 106
++T + D+N + K+K+ + EEKE P + A ++ ++E
Sbjct: 299 AETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQ 358
Query: 107 GSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSS 166
+ ++ + ++E K +++ + K+ + +EG++ + +
Sbjct: 359 KREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARAR 418
Query: 167 SDSDSSSEDEEFHDGYGEDLMG------DEEDRARLEQMTEKEREQELFNRIEKREVLKR 220
+++ + + +D + +++ R ++ Q E + E EV+++
Sbjct: 419 AEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQ 478
Query: 221 RFEIKKKLKTAKKKEKKEKKKK----------QEEEQEKKKLTQIQESQVTSHNKERRSK 270
K++ + E++E + +EE EK + ++ + +E +
Sbjct: 479 GVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEE 538
Query: 271 RDEKLDKKSQAMEELKAE-------REKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDK 323
+E+ D++S+ EE + E E K + K K S+ S D E + DD
Sbjct: 539 EEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDD- 597
Query: 324 SSEKSDRSSRTSSSDEEEEKEE 345
DR+ + D+ + + E
Sbjct: 598 -----DRTKEERAYDKAKRRIE 614
Score = 39.3 bits (90), Expect = 0.013
Identities = 60/311 (19%), Positives = 120/311 (38%), Gaps = 18/311 (5%)
Query: 23 GGQEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEK 82
G +E ++G T+ ++ + + E +E + L + KR + E
Sbjct: 323 GEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERL 382
Query: 83 EPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGS---- 138
E + + E + + K++++ +AR ++ Q + S S
Sbjct: 383 EQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKK 442
Query: 139 ----SDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRA 194
DK E EVS+S ++ E EE + D ED A
Sbjct: 443 RPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTED-A 501
Query: 195 RLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKK-----KKQEEEQEK 249
L+ ++E EK E K E+K+ + +++E++E++ +++EEE E
Sbjct: 502 GLDDWEAMASDEET----EKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGES 557
Query: 250 KKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTS 309
+ +E + S K+ D+K K+ + E ++ ++ K A AK++ K
Sbjct: 558 EGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRR 617
Query: 310 EVYSDDEEEEE 320
+S + E+
Sbjct: 618 LEHSKNVNTEK 628
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 78.2 bits (191), Expect = 2e-14
Identities = 97/500 (19%), Positives = 207/500 (41%), Gaps = 64/500 (12%)
Query: 71 LAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQA 130
+ + K ++S+E+ +S SE ++E GS++ K + +K+ ++A
Sbjct: 211 MVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERA 270
Query: 131 NKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDE 190
A K + A E + ++ +++++ E + + M +E
Sbjct: 271 RLEAEERERIKAEQDKKIADERARIE----------AEEKAAAQERERREAEERERMREE 320
Query: 191 EDRARLEQMTEKEREQELFNRIEK-REVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEK 249
E RA E+ KE E+ ++ +E KR E ++++K +K+ +E+++ + EE+EK
Sbjct: 321 EKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEK 380
Query: 250 KKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNR-----TAELLAKKQ 304
K+ + KR+++L++K AM+E K + EK + + E A++
Sbjct: 381 AKVEE--------------QKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQED 426
Query: 305 PLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRL 364
L+T+ + EE+ ++ + + + + EE + E+I +P EE+
Sbjct: 427 KLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP---KEEVKSFMD 483
Query: 365 SRHKLERWCHMPFFAKTVTGCFVRIGI---GNHNSKPVYRVAEITGVVETAKVYQLGGTR 421
+ K+ G F+ + N S+P R + T E A + G +
Sbjct: 484 RKKGFTE-------VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAG--K 534
Query: 422 TNKGLQLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDEINKKELSIKE 481
+ L+ R G E EF K K+ A ++L L + ++ + E
Sbjct: 535 RLEELRRRRG--------------ETESEEFEKLKQKQQEAALELEELKKKREERRKVLE 580
Query: 482 ALNYKFNDQDIEEIVKEKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDKAKQI-----Q 536
+ ++ + ++E+E R+ ++ + +++ + G D K +
Sbjct: 581 EEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPK 640
Query: 537 DQLNELEERAEALDRQRTKN 556
++EERAE L++ K+
Sbjct: 641 GSSLKIEERAEFLNKSVQKS 660
Score = 66.2 bits (160), Expect = 1e-10
Identities = 68/345 (19%), Positives = 152/345 (44%), Gaps = 37/345 (10%)
Query: 54 DTEDSGSDENLDQELL-------SLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTF 106
+ + GSDE E + + A+R R ++EE+E + A D + +D
Sbjct: 242 EEREQGSDEISHHEKMEEEDKERAEAERARLEAEERE----RIKAEQDKKIADERARIEA 297
Query: 107 GSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSS 166
++ + R+ E++ M+++ + A K+ + +A E + + + ++
Sbjct: 298 EEKAAAQERERREAEERERMREEEKRAAEERQRIKEEE-KRAAEERQRIKEEEKR---AA 353
Query: 167 SDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKK 226
+ E+E+ + +EE++A++E+ ++ +E + +++ ++ + E K
Sbjct: 354 EERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKI 413
Query: 227 KLKTAKKKEKKEKK------KKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQ 280
+ K +K+ +E K KKQ EE+ K + ++ Q ++ +DEK+ K +
Sbjct: 414 EGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKE 473
Query: 281 AMEELKAEREKR------KNRTAELLAKK---------QPLKTSEVYSDDEEEEEDDKSS 325
EE+K+ +++ K++ E + K +P + V + + E ++
Sbjct: 474 PKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAG 533
Query: 326 EKSDRSSRTSSSDEEEEKEEIPPKSQPVSLP-EELNRVRLSRHKL 369
++ + R E EE E++ K Q +L EEL + R R K+
Sbjct: 534 KRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 578
Score = 57.0 bits (136), Expect = 6e-08
Identities = 67/359 (18%), Positives = 155/359 (43%), Gaps = 57/359 (15%)
Query: 65 DQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARK-IEKK 123
++E L + + + P + ++ + + DDE F +++ + +K +++
Sbjct: 55 EEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEA 114
Query: 124 GTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYG 183
+K+ + T + S S + E E ++ + S S + E E Y
Sbjct: 115 LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE-ETETVTKSYQ 173
Query: 184 EDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEK------- 236
++ D E+ + +KE+E+E + ++ + + + E+ + KT + +E+
Sbjct: 174 KNDWRDAEENKK----EDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLK 229
Query: 237 ----KEKKKKQEEEQEK---------------KKLTQIQESQVTSHNKER-RSKRDEKL- 275
++ KQEEE+E+ K+ + + +++ + +ER ++++D+K+
Sbjct: 230 NGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIA 289
Query: 276 DKKSQAMEELKAEREKRKNRTAE-----------LLAKKQPLKTSEVYSDDE-------- 316
D++++ E KA ++R+ R AE ++Q +K E + +E
Sbjct: 290 DERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEE 349
Query: 317 ----EEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLER 371
EE + K EK R + EEEEK ++ + + L E+ + ++ ++ K E+
Sbjct: 350 KRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEK 408
Score = 52.0 bits (123), Expect = 2e-06
Identities = 68/314 (21%), Positives = 135/314 (42%), Gaps = 40/314 (12%)
Query: 66 QELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNK-KKGKARKIEKKG 124
+E + +R+R ++EE+E + +++ ++E + + K+ + R E++
Sbjct: 298 EEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQ 357
Query: 125 TMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSED-EEFHDGYG 183
+K++ + A + E + EE + + + ++ E E+ +G
Sbjct: 358 RIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKW 417
Query: 184 EDLMGDEEDRARLEQMTEKEREQELFNRIE-KREVLKRRFEIKKKLKTAKKKEKKEKKKK 242
+ +ED+ L+ K++ +E +++ KRE L+ KK + +K KK+K+ K
Sbjct: 418 VNEKKAQEDK--LQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPK 475
Query: 243 QEEEQ---EKKKLTQI--QESQVTSH------NKERRSKRDEKLDKKS----------QA 281
+E + KK T++ Q + +H N R +D K +
Sbjct: 476 EEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR 535
Query: 282 MEELKAEREKRKNRTAELLAKKQP---LKTSEVYSDDEE------EEEDDKSSEKSDRSS 332
+EEL+ R + ++ E L +KQ L+ E+ EE EEE + E++DR
Sbjct: 536 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKL 595
Query: 333 RTSSSDEEEEKEEI 346
R EEEEK +
Sbjct: 596 R-----EEEEKRRL 604
Score = 49.3 bits (116), Expect = 1e-05
Identities = 67/327 (20%), Positives = 131/327 (40%), Gaps = 37/327 (11%)
Query: 65 DQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKG 124
++E + +R+R EEK + A ++ E +E +KK ++ + KG
Sbjct: 347 EEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKG 406
Query: 125 TMKKQA--NKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSS-EDEEFHDG 181
+Q K + + +D + ++GE + + D + + EE D
Sbjct: 407 EKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKD- 465
Query: 182 YGEDLMGDEEDRARL------------------EQMTEKEREQE-LFNRIEKR-EVLKRR 221
E + D+E + + E MT K + E F+R R V +
Sbjct: 466 --EKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE 523
Query: 222 FEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQA 281
E +++ K+ E+ +++ + E +E +KL Q Q+ + +E + KR+E+ +
Sbjct: 524 AEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQ-EAALELEELKKKREERRKVLEEE 582
Query: 282 MEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEE 341
+ K E RK R E +K+ LK +E E +++EK + SD+++
Sbjct: 583 EQRRKQEEADRKLREEE---EKRRLK-------EEIERRRAEAAEKRQKMPEDGLSDDKK 632
Query: 342 EKEEIPPKSQPVSLPEELNRVRLSRHK 368
+ PK + + E + S K
Sbjct: 633 PFKCFTPKGSSLKIEERAEFLNKSVQK 659
Score = 39.7 bits (91), Expect = 0.010
Identities = 89/446 (19%), Positives = 187/446 (41%), Gaps = 98/446 (21%)
Query: 191 EDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKK 250
+D R ++ ++RE+ R+E + +R + ++ + A+++ ++ ++++ ++QE++
Sbjct: 2 DDFERRRELRRQKREEM---RLEAERIAYQRNDDDEE-EAARERRRRARQERLRQKQEEE 57
Query: 251 KLTQI--------------QESQVTSHNK-----------ERRSKRDEKLDKKSQ-AMEE 284
L Q+ +E++ T+ N ER ++R+E+ K+ Q A+E
Sbjct: 58 SLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALER 117
Query: 285 LKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDD--------------KSSEKSD- 329
K + + L +++ T+E + ++EE+ + KS +K+D
Sbjct: 118 QKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDW 177
Query: 330 RSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAKTVTGCFVRI 389
R + + +++E++EE K + S+ E V + E
Sbjct: 178 RDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTE------------------- 218
Query: 390 GIGNHNSKPVYRVAEITGVVETAKVYQLGGTRTNKGLQLRHGNDQRVFRLEFVSNQEFTE 449
++ VV + K Q+ + + G+D+ +S+ E E
Sbjct: 219 -------------SQEETVVMSLKNGQISSEEPKQEEEREQGSDE-------ISHHEKME 258
Query: 450 SEFMKWKEAMFSAGMQLPTLDEINKKELSIKEALNYKFNDQDIEEIVKEKERFRKAPPNY 509
E + EA A ++ + I K E K A + + + +E+ER R+A
Sbjct: 259 EEDKERAEAE-RARLEAEERERI-KAEQDKKIADERARIEAEEKAAAQERER-REAEERE 315
Query: 510 AMKKTQLLKEKAMAED---LGDQDKAKQIQDQLNELEERAEALDRQRTKNISAISYINQR 566
M++ +EK AE+ + +++K + Q + EE+ A +RQR K + +R
Sbjct: 316 RMRE----EEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRA-AEER 370
Query: 567 NREWNIVESEKALVAESHNMKNQQMD 592
R E EKA V E +N+Q++
Sbjct: 371 QRA-RAEEEEKAKVEE--QKRNKQLE 393
Score = 36.2 bits (82), Expect = 0.11
Identities = 79/362 (21%), Positives = 142/362 (39%), Gaps = 45/362 (12%)
Query: 267 RRSKRDE-KLDKKSQAME-----ELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEE 320
RR KR+E +L+ + A + E +A RE+R+ E L +KQ E ++ E
Sbjct: 11 RRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQ---EEESLGQVTDQVE 67
Query: 321 DDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAK 380
+ + D ++T++++ + E ++ + ++ EE + RL + LER F
Sbjct: 68 VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRL-QEALER---QKEFDP 123
Query: 381 TVTGCFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGTR--------TNKGLQLRHGN 432
T+T + S P R+ T ET + + +R T + N
Sbjct: 124 TITDASL--------SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKN 175
Query: 433 DQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDEINKKELSIKEALNYKFNDQDI 492
D R ++E E E K K ++E + ++ K
Sbjct: 176 DWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISS 235
Query: 493 EEIVKEKERFRKAPP-NYAMKKTQLLKEKAMAE----DLGDQDKAKQIQDQ-------LN 540
EE +E+ER + + ++ K + KE+A AE + ++++ K QD+
Sbjct: 236 EEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARI 295
Query: 541 ELEERAEALDRQRTKNISAISYINQRNR----EWNIVESEKALVAESHNMKNQQMDPFTR 596
E EE+A A +R+R + + R I E EK E +K ++
Sbjct: 296 EAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 355
Query: 597 RQ 598
RQ
Sbjct: 356 RQ 357
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 77.4 bits (189), Expect = 4e-14
Identities = 72/302 (23%), Positives = 137/302 (45%), Gaps = 45/302 (14%)
Query: 53 SDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNK 112
S ED SD+ ++ +KR+ + +E P + A + + SDSD E K
Sbjct: 1247 SSDEDGSSDDEPEEG------KKRTGKQNEENPGDEEAKNQVNSESDSDSE-----ESKK 1295
Query: 113 KKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSS 172
+ + R + K T S G S ++ + P+E + + SS DS
Sbjct: 1296 PRYRHRLLRHK--------LTVSDGESGEEKKTK---PKEHKEVKGRNRRKVSSEDS--- 1341
Query: 173 SEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAK 232
ED +F + + + + ED R + K+ E E R K++ +RR ++++ +
Sbjct: 1342 -EDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSEN 1400
Query: 233 KKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKE--------RRSKRDEKLDKKSQAMEE 284
K +E+++++EEE+E+++ + +E +K R+ +D+KL +++
Sbjct: 1401 KSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKL--RTETQNA 1458
Query: 285 LKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKE 344
LK E E+RK R AE +++ L+ E E +D S K +++ ++EE KE
Sbjct: 1459 LKEEEERRK-RIAEREREREKLR--------EVIEIEDASPTKCPITTKLVLDEDEETKE 1509
Query: 345 EI 346
+
Sbjct: 1510 PL 1511
Score = 75.5 bits (184), Expect = 2e-13
Identities = 99/436 (22%), Positives = 174/436 (39%), Gaps = 105/436 (24%)
Query: 32 GRRGSRGTTMVKK-RKGRVVIDSDTED--------SGSDENLDQELLSLAKRKRSDSEEK 82
GR R + K RK + SDTE + SD+ L + + L +R+ S+
Sbjct: 1050 GREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKR--IELRERRNLSSKRN 1107
Query: 83 EPPVSQPAASSDSETSDSDDEWTFGSNKNKKKG-----KARKIEKKGTMKKQANKTASS- 136
+ ++SSD+E S D++ +KKK K R + T +KQA+ T+SS
Sbjct: 1108 TKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSS 1167
Query: 137 -------------GSSDK-----------------------DSSAESSAPEEGEVSDSDS 160
GSSD+ D + S P + D D+
Sbjct: 1168 SDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDN 1227
Query: 161 N--------------SSSSSSDSDSSSEDEEFHDG------YGEDLMGDEEDRARLEQMT 200
+ ++ SSD D SS+DE +G E+ GDEE + ++ +
Sbjct: 1228 DPENRIAKKMLLEEIKANLSSDEDGSSDDEP-EEGKKRTGKQNEENPGDEEAKNQVNSES 1286
Query: 201 EKEREQELFNRIEKREVLKRRFEI-------KKKLKTAKKKEKK--EKKKKQEEEQEKKK 251
+ + E+ R R +L+ + + +KK K + KE K ++K E+ E
Sbjct: 1287 DSDSEESKKPRYRHR-LLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSD 1345
Query: 252 LTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEV 311
+ S+ S +++ + R KK++ E ++ ++K+K R K Q +SE
Sbjct: 1346 FQESGVSEEVSESEDEQRPRTRSA-KKAELEENQRSYKQKKKRRR----IKVQEDSSSEN 1400
Query: 312 YSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEK----------------EEIPPKSQPVSL 355
S+ EEEEE+ + E+ + DE ++ +++ ++Q
Sbjct: 1401 KSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALK 1460
Query: 356 PEELNRVRLSRHKLER 371
EE R R++ + ER
Sbjct: 1461 EEEERRKRIAERERER 1476
Score = 57.8 bits (138), Expect = 3e-08
Identities = 71/339 (20%), Positives = 140/339 (41%), Gaps = 48/339 (14%)
Query: 53 SDTEDSGSDENLDQELLSLAKR--KRSDSEEKEPPVSQ------------PAASSDSETS 98
S+T D SD + E+L++ K + S S + +++ A D +
Sbjct: 684 SETVDQNSDSD---EMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGK 740
Query: 99 DSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDS 158
T GS+ + KKGK+ K K+Q S SS+ DS E ++ +
Sbjct: 741 RKRKSSTSGSDFDTKKGKSAKSSIISKKKRQ----TQSESSNYDSELEKEIKSMSKIGAA 796
Query: 159 DSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMT---EKEREQELFNRIE-- 213
+ + D S ++E H G D G + + E + E+++E+E F+ E
Sbjct: 797 RTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGT 856
Query: 214 ---KREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTS-HNKERRS 269
+++ R + KK + + + +K +E+ ++ ++ E++ S H K +
Sbjct: 857 VDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTC 916
Query: 270 KR--------DEKLDKKSQAMEELKAEREKRKNRTAELLA----KKQPLKTSEVYSDDEE 317
K+ EK KK Q+ E + ++++ K T E KK+ +K + Y +
Sbjct: 917 KKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSD 976
Query: 318 ------EEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKS 350
E E+ K + + ++D E++ ++I K+
Sbjct: 977 GTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKT 1015
Score = 57.4 bits (137), Expect = 5e-08
Identities = 144/685 (21%), Positives = 260/685 (37%), Gaps = 82/685 (11%)
Query: 39 TTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKR-----SDSEEKEPPVSQPAASS 93
TT +++ + S++++ ++ +++ LS+ RK+ SDS P ++ S
Sbjct: 623 TTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSK 682
Query: 94 DSET----SDSDDEWTF---GSNKNKKKGKARKIEKKGTMKKQA-NKTASSGSSDKDSSA 145
SET SDSD+ S + I + T K + +G DK
Sbjct: 683 QSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRK 742
Query: 146 ESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARL-EQMTEKER 204
S+ + S+ SS S + + Y +L + + +++ T K+R
Sbjct: 743 RKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKR 802
Query: 205 --EQELFNRIEKREVLKRRFEIK--KKLKTAKKKEKKEKKKKQEEEQEKK------KLTQ 254
+ F+ E + K+ + + K LKT+++ + ++KQE E K T
Sbjct: 803 IPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTT 862
Query: 255 IQESQVTSHNKERRSKRDEKLDK---KSQAMEELKAEREKRKNRTAELLAKKQPLKTSEV 311
I E + K++ S + +DK K Q+ L+ + ++ L K K +
Sbjct: 863 IMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDG 922
Query: 312 YSDDEEE-EEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKL- 369
SD E+ + D+S E S+ + S EE+K+ K + + + ++ KL
Sbjct: 923 LSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLP 982
Query: 370 --ERWCHMPFFAKTVTGCFVRIGIGNHNSKPV-----YRVAEITGVVE--TAKVYQLGGT 420
E CH P K + G SK + + E++ E T K +
Sbjct: 983 EREEICHFPKGIKQIKNGTTD---GEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSS 1039
Query: 421 RTNKGLQLRHGNDQRVFRLEFVSN---QEFTESEFMKW---KEAMFSAGMQLPTLDEINK 474
K +G +++ +L S+ Q+ + S+ K+ ++ S+ +L ++ +
Sbjct: 1040 EDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRER 1099
Query: 475 KELSIK---EALNYKFNDQDIEEIVKEKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDK 531
+ LS K + + + D EE ++ +K + KK ++KEK L K
Sbjct: 1100 RNLSSKRNTKEIQSGSSSSDAEE--SSEDNKKKKQRTSSKKKAVIVKEK-KRNSLRTSTK 1156
Query: 532 AKQIQDQLNELEERAEALDRQRTKNISAISYINQRNREWNIVESEKALVAESHNMKNQQM 591
KQ D + E D+ S + E I + LV SH Q
Sbjct: 1157 RKQ-ADITSSSSSDIEDDDQN--------SIGEGSSDEQKIKPVTENLVLSSHTGFCQSS 1207
Query: 592 DPFTRRQCKPTIV---SNSRDPAVQAA---ILAQLNAKYGS---GVLPDAPKEMSKGQGK 642
+ P V + DP + A +L ++ A S G D P+E K GK
Sbjct: 1208 GDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGK 1267
Query: 643 DKD-----------LNSKSASDLSE 656
+ +NS+S SD E
Sbjct: 1268 QNEENPGDEEAKNQVNSESDSDSEE 1292
Score = 55.1 bits (131), Expect = 2e-07
Identities = 56/219 (25%), Positives = 92/219 (42%), Gaps = 27/219 (12%)
Query: 42 VKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSD 101
VK R R V D+EDS E S + S+SE+++ P ++ A ++ E +
Sbjct: 1328 VKGRNRRKVSSEDSEDSDFQE-------SGVSEEVSESEDEQRPRTRSAKKAELEENQR- 1379
Query: 102 DEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSN 161
S K KKK + K+++ + + ++N S +++ E EE E + D N
Sbjct: 1380 ------SYKQKKKRRRIKVQEDSSSENKSN----SEEEEEEKEEEEEEEEEEEEEEEDEN 1429
Query: 162 SSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRR 221
S S + D D + E A E E+ER + + R +RE L+
Sbjct: 1430 DDSKSPGKGRKKIRKILKD----DKLRTETQNALKE---EEERRKRIAEREREREKLREV 1482
Query: 222 FEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQV 260
EI+ T K K E+E+ K+ L Q+ + V
Sbjct: 1483 IEIEDASPT--KCPITTKLVLDEDEETKEPLVQVHRNMV 1519
Score = 54.3 bits (129), Expect = 4e-07
Identities = 71/330 (21%), Positives = 140/330 (42%), Gaps = 47/330 (14%)
Query: 27 GSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPV 86
GS ++G + + +K R + +E S D L++E+ S++K + + +K P
Sbjct: 749 GSDFDTKKGKSAKSSIISKKKR---QTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPN 805
Query: 87 SQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAE 146
++ SS+ E K+ KKG ++ +G + ++ SS +++ E
Sbjct: 806 TKDFDSSEDE-------------KHSKKG----MDNQGHKNLKTSQEGSSDDAERKQERE 848
Query: 147 SSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLE--QMTE-KE 203
+ + EG V D D+ + DG + L G E+ LE ++ E KE
Sbjct: 849 TFSSAEGTV-DKDTTIMELRDRLPKKQQASASTDGV-DKLSGKEQSFTSLEVRKVAETKE 906
Query: 204 REQELFNRIEKR---------EVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQ 254
+ + L + K+ E ++ + + + KK+ KK ++K++ KKK+ +
Sbjct: 907 KSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIK 966
Query: 255 IQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSD 314
+++ E S EKL ++ + K ++ KN T + K + ++
Sbjct: 967 MEQQY------ESSSDGTEKLPEREEICHFPKGIKQ-IKNGTTDGEKKSKKIRDKTSKKK 1019
Query: 315 DEEEEEDDKSSEKSDRSSRTSSSDEEEEKE 344
DE + +KS+ K D S D E+K+
Sbjct: 1020 DELSDYAEKSTGKGD------SCDSSEDKK 1043
Score = 35.0 bits (79), Expect = 0.24
Identities = 61/299 (20%), Positives = 108/299 (36%), Gaps = 18/299 (6%)
Query: 50 VIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSN 109
++D T + ENL+Q L K+ + DSE+ + S +TS SN
Sbjct: 235 LLDLVTACNSVFENLEQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTS---------SN 285
Query: 110 KNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDS 169
N G+ +K++ + + +A + A+ ++ S ++D+
Sbjct: 286 CN---GEEKKLDDSCSGSVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDN 342
Query: 170 DSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLK 229
S + + + +A L + E + + K + K I K +
Sbjct: 343 SEISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFE 402
Query: 230 TAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAER 289
T K K EK E++ K ++ QV S + + +E+ KS E K++R
Sbjct: 403 T--KARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDR 460
Query: 290 EKRKN----RTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKE 344
++ T+E L S V D E E + S SS E+E E
Sbjct: 461 KEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVE 519
Score = 31.2 bits (69), Expect = 3.5
Identities = 23/97 (23%), Positives = 42/97 (43%), Gaps = 6/97 (6%)
Query: 264 NKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDK 323
NKE+ +K + +D K E KA + ++ + K K S D E ++
Sbjct: 386 NKEKNTKEHKVIDAKF----ETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVP 441
Query: 324 SSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELN 360
+ E+ S + + KEE P+ +P + E+L+
Sbjct: 442 TEEQRTNKSTGGEHKKSDRKEE--PQYEPANTSEDLD 476
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 77.4 bits (189), Expect = 4e-14
Identities = 72/302 (23%), Positives = 137/302 (45%), Gaps = 45/302 (14%)
Query: 53 SDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNK 112
S ED SD+ ++ +KR+ + +E P + A + + SDSD E K
Sbjct: 1285 SSDEDGSSDDEPEEG------KKRTGKQNEENPGDEEAKNQVNSESDSDSE-----ESKK 1333
Query: 113 KKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSS 172
+ + R + K T S G S ++ + P+E + + SS DS
Sbjct: 1334 PRYRHRLLRHK--------LTVSDGESGEEKKTK---PKEHKEVKGRNRRKVSSEDS--- 1379
Query: 173 SEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAK 232
ED +F + + + + ED R + K+ E E R K++ +RR ++++ +
Sbjct: 1380 -EDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSEN 1438
Query: 233 KKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKE--------RRSKRDEKLDKKSQAMEE 284
K +E+++++EEE+E+++ + +E +K R+ +D+KL +++
Sbjct: 1439 KSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKL--RTETQNA 1496
Query: 285 LKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKE 344
LK E E+RK R AE +++ L+ E E +D S K +++ ++EE KE
Sbjct: 1497 LKEEEERRK-RIAEREREREKLR--------EVIEIEDASPTKCPITTKLVLDEDEETKE 1547
Query: 345 EI 346
+
Sbjct: 1548 PL 1549
Score = 75.5 bits (184), Expect = 2e-13
Identities = 99/436 (22%), Positives = 174/436 (39%), Gaps = 105/436 (24%)
Query: 32 GRRGSRGTTMVKK-RKGRVVIDSDTED--------SGSDENLDQELLSLAKRKRSDSEEK 82
GR R + K RK + SDTE + SD+ L + + L +R+ S+
Sbjct: 1088 GREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKR--IELRERRNLSSKRN 1145
Query: 83 EPPVSQPAASSDSETSDSDDEWTFGSNKNKKKG-----KARKIEKKGTMKKQANKTASS- 136
+ ++SSD+E S D++ +KKK K R + T +KQA+ T+SS
Sbjct: 1146 TKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSS 1205
Query: 137 -------------GSSDK-----------------------DSSAESSAPEEGEVSDSDS 160
GSSD+ D + S P + D D+
Sbjct: 1206 SDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDN 1265
Query: 161 N--------------SSSSSSDSDSSSEDEEFHDG------YGEDLMGDEEDRARLEQMT 200
+ ++ SSD D SS+DE +G E+ GDEE + ++ +
Sbjct: 1266 DPENRIAKKMLLEEIKANLSSDEDGSSDDEP-EEGKKRTGKQNEENPGDEEAKNQVNSES 1324
Query: 201 EKEREQELFNRIEKREVLKRRFEI-------KKKLKTAKKKEKK--EKKKKQEEEQEKKK 251
+ + E+ R R +L+ + + +KK K + KE K ++K E+ E
Sbjct: 1325 DSDSEESKKPRYRHR-LLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSD 1383
Query: 252 LTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEV 311
+ S+ S +++ + R KK++ E ++ ++K+K R K Q +SE
Sbjct: 1384 FQESGVSEEVSESEDEQRPRTRSA-KKAELEENQRSYKQKKKRRR----IKVQEDSSSEN 1438
Query: 312 YSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEK----------------EEIPPKSQPVSL 355
S+ EEEEE+ + E+ + DE ++ +++ ++Q
Sbjct: 1439 KSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALK 1498
Query: 356 PEELNRVRLSRHKLER 371
EE R R++ + ER
Sbjct: 1499 EEEERRKRIAERERER 1514
Score = 57.8 bits (138), Expect = 3e-08
Identities = 71/339 (20%), Positives = 140/339 (41%), Gaps = 48/339 (14%)
Query: 53 SDTEDSGSDENLDQELLSLAKR--KRSDSEEKEPPVSQ------------PAASSDSETS 98
S+T D SD + E+L++ K + S S + +++ A D +
Sbjct: 722 SETVDQNSDSD---EMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGK 778
Query: 99 DSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDS 158
T GS+ + KKGK+ K K+Q S SS+ DS E ++ +
Sbjct: 779 RKRKSSTSGSDFDTKKGKSAKSSIISKKKRQ----TQSESSNYDSELEKEIKSMSKIGAA 834
Query: 159 DSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMT---EKEREQELFNRIE-- 213
+ + D S ++E H G D G + + E + E+++E+E F+ E
Sbjct: 835 RTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGT 894
Query: 214 ---KREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTS-HNKERRS 269
+++ R + KK + + + +K +E+ ++ ++ E++ S H K +
Sbjct: 895 VDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTC 954
Query: 270 KR--------DEKLDKKSQAMEELKAEREKRKNRTAELLA----KKQPLKTSEVYSDDEE 317
K+ EK KK Q+ E + ++++ K T E KK+ +K + Y +
Sbjct: 955 KKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSD 1014
Query: 318 ------EEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKS 350
E E+ K + + ++D E++ ++I K+
Sbjct: 1015 GTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKT 1053
Score = 57.4 bits (137), Expect = 5e-08
Identities = 144/685 (21%), Positives = 260/685 (37%), Gaps = 82/685 (11%)
Query: 39 TTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKR-----SDSEEKEPPVSQPAASS 93
TT +++ + S++++ ++ +++ LS+ RK+ SDS P ++ S
Sbjct: 661 TTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSK 720
Query: 94 DSET----SDSDDEWTF---GSNKNKKKGKARKIEKKGTMKKQA-NKTASSGSSDKDSSA 145
SET SDSD+ S + I + T K + +G DK
Sbjct: 721 QSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRK 780
Query: 146 ESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARL-EQMTEKER 204
S+ + S+ SS S + + Y +L + + +++ T K+R
Sbjct: 781 RKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKR 840
Query: 205 --EQELFNRIEKREVLKRRFEIK--KKLKTAKKKEKKEKKKKQEEEQEKK------KLTQ 254
+ F+ E + K+ + + K LKT+++ + ++KQE E K T
Sbjct: 841 IPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTT 900
Query: 255 IQESQVTSHNKERRSKRDEKLDK---KSQAMEELKAEREKRKNRTAELLAKKQPLKTSEV 311
I E + K++ S + +DK K Q+ L+ + ++ L K K +
Sbjct: 901 IMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDG 960
Query: 312 YSDDEEE-EEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKL- 369
SD E+ + D+S E S+ + S EE+K+ K + + + ++ KL
Sbjct: 961 LSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLP 1020
Query: 370 --ERWCHMPFFAKTVTGCFVRIGIGNHNSKPV-----YRVAEITGVVE--TAKVYQLGGT 420
E CH P K + G SK + + E++ E T K +
Sbjct: 1021 EREEICHFPKGIKQIKNGTTD---GEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSS 1077
Query: 421 RTNKGLQLRHGNDQRVFRLEFVSN---QEFTESEFMKW---KEAMFSAGMQLPTLDEINK 474
K +G +++ +L S+ Q+ + S+ K+ ++ S+ +L ++ +
Sbjct: 1078 EDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRER 1137
Query: 475 KELSIK---EALNYKFNDQDIEEIVKEKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDK 531
+ LS K + + + D EE ++ +K + KK ++KEK L K
Sbjct: 1138 RNLSSKRNTKEIQSGSSSSDAEE--SSEDNKKKKQRTSSKKKAVIVKEK-KRNSLRTSTK 1194
Query: 532 AKQIQDQLNELEERAEALDRQRTKNISAISYINQRNREWNIVESEKALVAESHNMKNQQM 591
KQ D + E D+ S + E I + LV SH Q
Sbjct: 1195 RKQ-ADITSSSSSDIEDDDQN--------SIGEGSSDEQKIKPVTENLVLSSHTGFCQSS 1245
Query: 592 DPFTRRQCKPTIV---SNSRDPAVQAA---ILAQLNAKYGS---GVLPDAPKEMSKGQGK 642
+ P V + DP + A +L ++ A S G D P+E K GK
Sbjct: 1246 GDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGK 1305
Query: 643 DKD-----------LNSKSASDLSE 656
+ +NS+S SD E
Sbjct: 1306 QNEENPGDEEAKNQVNSESDSDSEE 1330
Score = 55.1 bits (131), Expect = 2e-07
Identities = 56/219 (25%), Positives = 92/219 (42%), Gaps = 27/219 (12%)
Query: 42 VKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSD 101
VK R R V D+EDS E S + S+SE+++ P ++ A ++ E +
Sbjct: 1366 VKGRNRRKVSSEDSEDSDFQE-------SGVSEEVSESEDEQRPRTRSAKKAELEENQR- 1417
Query: 102 DEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSN 161
S K KKK + K+++ + + ++N S +++ E EE E + D N
Sbjct: 1418 ------SYKQKKKRRRIKVQEDSSSENKSN----SEEEEEEKEEEEEEEEEEEEEEEDEN 1467
Query: 162 SSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRR 221
S S + D D + E A E E+ER + + R +RE L+
Sbjct: 1468 DDSKSPGKGRKKIRKILKD----DKLRTETQNALKE---EEERRKRIAEREREREKLREV 1520
Query: 222 FEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQV 260
EI+ T K K E+E+ K+ L Q+ + V
Sbjct: 1521 IEIEDASPT--KCPITTKLVLDEDEETKEPLVQVHRNMV 1557
Score = 54.3 bits (129), Expect = 4e-07
Identities = 71/330 (21%), Positives = 140/330 (42%), Gaps = 47/330 (14%)
Query: 27 GSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPV 86
GS ++G + + +K R + +E S D L++E+ S++K + + +K P
Sbjct: 787 GSDFDTKKGKSAKSSIISKKKR---QTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPN 843
Query: 87 SQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAE 146
++ SS+ E K+ KKG ++ +G + ++ SS +++ E
Sbjct: 844 TKDFDSSEDE-------------KHSKKG----MDNQGHKNLKTSQEGSSDDAERKQERE 886
Query: 147 SSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLE--QMTE-KE 203
+ + EG V D D+ + DG + L G E+ LE ++ E KE
Sbjct: 887 TFSSAEGTV-DKDTTIMELRDRLPKKQQASASTDGV-DKLSGKEQSFTSLEVRKVAETKE 944
Query: 204 REQELFNRIEKR---------EVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQ 254
+ + L + K+ E ++ + + + KK+ KK ++K++ KKK+ +
Sbjct: 945 KSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIK 1004
Query: 255 IQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSD 314
+++ E S EKL ++ + K ++ KN T + K + ++
Sbjct: 1005 MEQQY------ESSSDGTEKLPEREEICHFPKGIKQ-IKNGTTDGEKKSKKIRDKTSKKK 1057
Query: 315 DEEEEEDDKSSEKSDRSSRTSSSDEEEEKE 344
DE + +KS+ K D S D E+K+
Sbjct: 1058 DELSDYAEKSTGKGD------SCDSSEDKK 1081
Score = 35.0 bits (79), Expect = 0.24
Identities = 61/299 (20%), Positives = 108/299 (36%), Gaps = 18/299 (6%)
Query: 50 VIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSN 109
++D T + ENL+Q L K+ + DSE+ + S +TS SN
Sbjct: 273 LLDLVTACNSVFENLEQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTS---------SN 323
Query: 110 KNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDS 169
N G+ +K++ + + +A + A+ ++ S ++D+
Sbjct: 324 CN---GEEKKLDDSCSGSVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDN 380
Query: 170 DSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLK 229
S + + + +A L + E + + K + K I K +
Sbjct: 381 SEISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFE 440
Query: 230 TAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAER 289
T K K EK E++ K ++ QV S + + +E+ KS E K++R
Sbjct: 441 T--KARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDR 498
Query: 290 EKRKN----RTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKE 344
++ T+E L S V D E E + S SS E+E E
Sbjct: 499 KEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVE 557
Score = 31.2 bits (69), Expect = 3.5
Identities = 23/97 (23%), Positives = 42/97 (43%), Gaps = 6/97 (6%)
Query: 264 NKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDK 323
NKE+ +K + +D K E KA + ++ + K K S D E ++
Sbjct: 424 NKEKNTKEHKVIDAKF----ETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVP 479
Query: 324 SSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELN 360
+ E+ S + + KEE P+ +P + E+L+
Sbjct: 480 TEEQRTNKSTGGEHKKSDRKEE--PQYEPANTSEDLD 514
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 73.9 bits (180), Expect = 5e-13
Identities = 58/330 (17%), Positives = 137/330 (41%), Gaps = 5/330 (1%)
Query: 43 KKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDD 102
K+R + + +TE G + D++ +R+R EKE +
Sbjct: 119 KERNRQKERERETEREG-ERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQK 177
Query: 103 EWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNS 162
E N+ +++ + R+ EK+ + + ++ ++++ E+ + +
Sbjct: 178 EREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRK 237
Query: 163 SSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRF 222
+ + + E + + E DR R +KERE++ + ++R R
Sbjct: 238 TEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRET 297
Query: 223 EIKKKLKTAKKKEK-KEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQA 281
E K++ + +++E+ + +K+++E E+E+++ Q + + +ER+ KR ++D++
Sbjct: 298 ERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNR 357
Query: 282 MEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEE 341
+ R+ + R E +Q + E + E + + D+ E+ ++ + E
Sbjct: 358 QTGREGRRQAERERERERERDRQSARERE---ERERDRDRDRQKERERQTEKDRDGQRET 414
Query: 342 EKEEIPPKSQPVSLPEELNRVRLSRHKLER 371
EK+ K + E R R + ER
Sbjct: 415 EKQREREKDRESERGRERGREREKQKGRER 444
Score = 69.7 bits (169), Expect = 9e-12
Identities = 65/319 (20%), Positives = 135/319 (42%), Gaps = 18/319 (5%)
Query: 32 GRRG-SRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPA 90
G RG R T ++R+ + + + E E Q + K + + +E +
Sbjct: 135 GERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQ 194
Query: 91 ASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKG-TMKKQANKTASSGSSDKDSSAESSA 149
+++T D E G + +++ + E+K T +++ + + +K + E ++
Sbjct: 195 REKENKTEDRHSER--GRERERERETETETERKRQTDRERDRQRKTEREREKQAERERAS 252
Query: 150 PEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMG--DEEDRARLEQMTEKEREQE 207
E E D D ++ E D E + E+ E+ERE+E
Sbjct: 253 ERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERE 312
Query: 208 LFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEE-EQEKKKLTQIQESQVTSHNKE 266
+ E+ +R E +++ + ++KE++ K+K+Q E ++E+ + T + + +E
Sbjct: 313 RNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERE 372
Query: 267 RRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSE 326
R +RD + A E + ER++ ++R +K+ + +E D + E E + E
Sbjct: 373 RERERD-----RQSAREREERERDRDRDR------QKERERQTEKDRDGQRETEKQRERE 421
Query: 327 KSDRSSRTSSSDEEEEKEE 345
K S R E EK++
Sbjct: 422 KDRESERGRERGREREKQK 440
Score = 68.9 bits (167), Expect = 2e-11
Identities = 75/353 (21%), Positives = 146/353 (41%), Gaps = 35/353 (9%)
Query: 49 VVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGS 108
+ +D GS E+ + L A K +D +++E Q E ++ E
Sbjct: 22 IPLDFSRRRPGSQESPRRRGLGQA-HKDADGDDRERN-RQKERERRREKRQTERETDRKR 79
Query: 109 NKNKKKGKARKIEKKGTMKKQANKTASSGSS---DKDSSAESSAPEEGEVSDSDSNSSSS 165
+ ++K + RK ++ ++ K + D+ E + +E E
Sbjct: 80 ERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGR 139
Query: 166 SSDSDSSSEDEEFHDGYGE-DLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEI 224
+D E E D E + D E + + E+ +KERE+E NR E+RE ++R +
Sbjct: 140 DRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREK-NRQERRERERQREKE 198
Query: 225 KK------------------KLKTAKKKE---KKEKKKKQEEEQEKKKLTQIQESQVTSH 263
K + +T +K++ ++++++K E E+EK+ + + T
Sbjct: 199 NKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETER 258
Query: 264 NKERRSKRDEKLDKKSQAME---ELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEE 320
+KER +RD D+ + E + +R++R R E K++ + E + + E
Sbjct: 259 DKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRE 318
Query: 321 DDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRV--RLSRHKLER 371
++ E+ R + D E+E+E + + + E NR R R + ER
Sbjct: 319 RERERERERERQRETERDREKERER--KRKRQTEMDRERNRQTGREGRRQAER 369
Score = 50.8 bits (120), Expect = 4e-06
Identities = 40/239 (16%), Positives = 104/239 (43%), Gaps = 15/239 (6%)
Query: 74 RKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKT 133
R+R E+E + AS D + E ++++ + + +K ++ T +K+ +T
Sbjct: 234 RQRKTEREREKQAERERASERETERDKERERE--RDRDRDRDRRQKERERQTDRKRQRRT 291
Query: 134 ASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDR 193
+++ + E E + + + E E D + E +
Sbjct: 292 ERDRETERKRERQRERERERERNRKRERERERERERERQRETER-------DREKERERK 344
Query: 194 ARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEK------KKKQEEEQ 247
+ + ++ER ++ ++ +R E ++ ++A+++E++E+ +K++E +
Sbjct: 345 RKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQT 404
Query: 248 EKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPL 306
EK + Q + + K+R S+R + ++ + + + +RE++ +R A K+ L
Sbjct: 405 EKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTL 463
Score = 50.1 bits (118), Expect = 7e-06
Identities = 46/285 (16%), Positives = 113/285 (39%), Gaps = 25/285 (8%)
Query: 52 DSDTEDS----GSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFG 107
++ TED G + ++E + +RKR E++ + E
Sbjct: 198 ENKTEDRHSERGRERERERETETETERKRQTDRERD------RQRKTEREREKQAERERA 251
Query: 108 SNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSS 167
S + ++ K R+ E+ + + +D+ + E E
Sbjct: 252 SERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERER 311
Query: 168 DSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKK 227
+ + E E + E E DR EKERE R KR+ + ++
Sbjct: 312 ERNRKRERERERERERERQRETERDR-------EKERE-----RKRKRQT---EMDRERN 356
Query: 228 LKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKA 287
+T ++ ++ +++++ E + ++ + +E + +++R+ +R+ + +K E +
Sbjct: 357 RQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEK 416
Query: 288 EREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSS 332
+RE+ K+R +E ++ + + + + E + D+ + + + S
Sbjct: 417 QREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRS 461
Score = 34.3 bits (77), Expect = 0.41
Identities = 34/199 (17%), Positives = 79/199 (39%), Gaps = 23/199 (11%)
Query: 73 KRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANK 132
+RKR E+E + + + E + ++++K + RK +++ M ++ N+
Sbjct: 298 ERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNR 357
Query: 133 TASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEED 192
EG D S+ E EE + D +
Sbjct: 358 QTG---------------REGRRQAERERERERERDRQSAREREE------RERDRDRDR 396
Query: 193 RARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKL 252
+ E+ TEK+R+ + EK+ ++ E ++ + +++EK++ +++ E Q ++
Sbjct: 397 QKERERQTEKDRDGQ--RETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQA 454
Query: 253 TQIQESQVTSHNKERRSKR 271
+ ++ N R+ R
Sbjct: 455 GRQRKRSTLYVNPPPRTAR 473
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 73.2 bits (178), Expect = 8e-13
Identities = 78/313 (24%), Positives = 138/313 (44%), Gaps = 35/313 (11%)
Query: 42 VKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPP-VSQPAASSDSETSDS 100
VKKR E S S E + + KR RS S+ ++ V + SDS+ D
Sbjct: 452 VKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQ 511
Query: 101 DDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPE----EGEVS 156
+ +++ K K++++E K +N+ S S +KD A+S + E +G+ S
Sbjct: 512 E--------RSRSKEKSKQLESK------SNEHDHSKSKEKDRRAQSRSRECDITKGKHS 557
Query: 157 DSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKRE 216
+ S S S HD DR+R ++ + REQE R R
Sbjct: 558 YNSRTRERSRSRDRSRRVRSRTHD----------RDRSRSKEY-HRYREQEYRRRGRSRS 606
Query: 217 VLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLD 276
+R + + K +++ + + ++EE Q + K + +SH KE S+ ++++
Sbjct: 607 RERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKE-NSESEKRMY 665
Query: 277 KKSQAMEELKAEREKRKNRTAELLAK-KQPLKTSEVYSDDEEEEEDDK---SSEKSDRSS 332
KS+ REK+ +R +K KQ + +E+ S + +ED+K S EK ++ S
Sbjct: 666 SKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKS 725
Query: 333 RTSSSDEEEEKEE 345
+ +D EK +
Sbjct: 726 KGQENDHVHEKNK 738
Score = 62.0 bits (149), Expect = 2e-09
Identities = 69/373 (18%), Positives = 142/373 (38%), Gaps = 55/373 (14%)
Query: 51 IDSDTEDSGSDENLDQELLS---LAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFG 107
I++ D+ S + +LS L + + EEK+ S ++SS S SDS +
Sbjct: 154 IENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSS 213
Query: 108 SNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSS 167
S+ + + + KK K + N K ++ SA E E + ++ S+
Sbjct: 214 SDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVR 273
Query: 168 DSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKE------------------------ 203
+ E DE++R E+ E+E
Sbjct: 274 PEEIPPIPENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKI 333
Query: 204 --------------REQELFNRIEKREVLKRRFEIKKKLKTAKKKE--KKEKKKKQEEEQ 247
R ++ F R E ++ + ++++ + + K +K + E ++
Sbjct: 334 KGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKE 393
Query: 248 EKKKLTQIQESQVTSH----------NKERRSKRDEKLDKKSQAMEELKAEREKRKNRTA 297
++ +++E ++T H N++ + +D K + K + + + +K KN+
Sbjct: 394 NQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVK 453
Query: 298 ELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPE 357
+ K K+ E E + + +++ EK R SR+ D E KE+ +S +
Sbjct: 454 KRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMR-SRSKGRDHENVKEK-EKQSDSKGKDQ 511
Query: 358 ELNRVRLSRHKLE 370
E +R + +LE
Sbjct: 512 ERSRSKEKSKQLE 524
Score = 51.2 bits (121), Expect = 3e-06
Identities = 53/215 (24%), Positives = 87/215 (40%), Gaps = 8/215 (3%)
Query: 159 DSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVL 218
D+N S + + + H +G+ + G E R Q T+ + RI L
Sbjct: 118 DTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGEL 177
Query: 219 KRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKK 278
+ ++KK+ K K + + + S S +E+ KR +K K
Sbjct: 178 IPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKN 237
Query: 279 SQAMEELKAEREK-RKNRTAELLAKK---QPLKT---SEVYSDDEEEEEDDKSSEKSDRS 331
S+ ++ K +R+K +K+ ++E A+ QP T E+ E KS K+D
Sbjct: 238 SRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEK 297
Query: 332 SRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSR 366
R + + E E+E PP SQP S L R R
Sbjct: 298 ER-KNRERERERECNPPNSQPASYQRRLLVTRSGR 331
Score = 46.2 bits (108), Expect = 1e-04
Identities = 38/178 (21%), Positives = 79/178 (44%), Gaps = 15/178 (8%)
Query: 192 DRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKK 251
D++ L ++ E +R R+++R++ R + K EK+KK ++ + K
Sbjct: 384 DKSELNEIKENQRSPV---RVKERKITDHRNV------SESPNRKNEKEKKVKDHKSNSK 434
Query: 252 LTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKA-EREKRKNRTAELLAKKQPLKTSE 310
I+ + + + K+ K +S++ E+ K+ ER+ + NR E + +++
Sbjct: 435 ERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEE-----KRMRSRS 489
Query: 311 VYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHK 368
D E +E +K S+ + S S E+ ++ E S +E +R SR +
Sbjct: 490 KGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSR 547
Score = 45.1 bits (105), Expect = 2e-04
Identities = 52/281 (18%), Positives = 106/281 (37%), Gaps = 16/281 (5%)
Query: 74 RKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKT 133
R R E P Q + S + W G K + +I++ + +
Sbjct: 350 RDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGD-----KSELNEIKENQRSPVRVKER 404
Query: 134 ASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDR 193
+ + S +E +V D SNS +S +D+ Y + + +
Sbjct: 405 KITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDK-----YKNKVKKRAKSK 459
Query: 194 ARLEQMTEKEREQELFNRIEKREVLKRRFEIK-KKLKTAKKKEKK--EKKKKQEEEQEKK 250
+R + EK + +E ++ + E + R K + + K+KEK+ K K QE + K+
Sbjct: 460 SR-SKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKE 518
Query: 251 KLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSE 310
K Q+ ES+ H+ + ++D + +S+ + K + +RT E + +
Sbjct: 519 KSKQL-ESKSNEHDHSKSKEKDRRAQSRSRECDITKG-KHSYNSRTRERSRSRDRSRRVR 576
Query: 311 VYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQ 351
+ D + + ++ R E+ P +S+
Sbjct: 577 SRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSR 617
Score = 34.7 bits (78), Expect = 0.31
Identities = 31/139 (22%), Positives = 59/139 (42%), Gaps = 3/139 (2%)
Query: 37 RGTTMVKKRKGRVVIDSDTEDSGS---DENLDQELLSLAKRKRSDSEEKEPPVSQPAASS 93
R + ++R+ R S+ E+S S D+ +QE S +++ S+SE++ S+ SS
Sbjct: 615 RSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSS 674
Query: 94 DSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEG 153
++ D +K K+ + +++ K+ K SS + S
Sbjct: 675 NNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVH 734
Query: 154 EVSDSDSNSSSSSSDSDSS 172
E + + SS +D D S
Sbjct: 735 EKNKKFDHESSPGTDEDKS 753
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 72.8 bits (177), Expect = 1e-12
Identities = 109/594 (18%), Positives = 239/594 (40%), Gaps = 54/594 (9%)
Query: 26 EGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPP 85
E PG RR R + +G + D E L +++ + EE+
Sbjct: 130 EEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAE 189
Query: 86 VSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSA 145
Q + ET + DE + ++ + ++ +KG +KQ + ++
Sbjct: 190 EEQLQSCKGHETEEFPDE------EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEE 243
Query: 146 ESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFH------DGYGEDLMGDEEDRARL--- 196
+ E + + ++EE + +E+ + RL
Sbjct: 244 KEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRRE 303
Query: 197 EQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQ------EEEQEKK 250
+Q+ K+ E+ + E+RE +RR + +++ + ++E++E++++Q EE +E++
Sbjct: 304 QQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQ 363
Query: 251 -KLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTS 309
+ Q +E + +E++ +R+++L ++ Q E + RE++ R + L ++Q L+
Sbjct: 364 LRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ-LRREQQLRRE 422
Query: 310 EVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEE----EKEEIPPKSQPVSLPEELNRVRLS 365
+ ++EEE ++ E+ R R EE ++EE + + ++L R +
Sbjct: 423 QQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQ-E 481
Query: 366 RHKLERWCHMPFFAKTVTGCFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGTRTNKG 425
+ ERW +++ + R ++ E + +L +
Sbjct: 482 EERRERW--------------LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEER 527
Query: 426 LQLRHGNDQRVFRLEFVSNQEFTESEFMKWKE----AMFSAGMQLPTLDEINKKELSIKE 481
LQ R ++Q++ R + ++ + E K E Q D++ K+E ++
Sbjct: 528 LQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQ 587
Query: 482 ALNYKFNDQDIEEIVK--EKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDKAKQIQDQL 539
+ ++ +E+ +K E ER + K + +E+ + L +++ ++ Q QL
Sbjct: 588 QRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQL 647
Query: 540 -NELEERAEALDRQRTKNISAISYINQR-NREWNIVESEKALVAESHNMKNQQM 591
E +ER E QR K + QR RE E+ L E +++
Sbjct: 648 RREQQERRE----QRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERI 697
Score = 72.0 bits (175), Expect = 2e-12
Identities = 105/568 (18%), Positives = 234/568 (41%), Gaps = 63/568 (11%)
Query: 61 DENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKI 120
+E + QE L R + E++ + + E +++ + +++ + R+
Sbjct: 1143 EEEVQQEEEQLL---REEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199
Query: 121 EKKGTMKKQANKTASSGSSDKDSSAESSAPE-EGEVSDSDSNSSSSSSDSDSSSEDEEFH 179
++ +++Q K + PE E V D+ ++ ED +
Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLR 1259
Query: 180 DGYGED----LMGD------EEDRARLEQMTEKEREQELFNRIEKREVLKR--RFEIKKK 227
D + L+G+ E++R R +Q E+E R E++E +R + + +K+
Sbjct: 1260 DRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQ 1319
Query: 228 LKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKA 287
L +++EK+ +++ + +E+++L Q +E Q + R R+E+L + Q + L+
Sbjct: 1320 LLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEE 1379
Query: 288 E-REKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDE-EEEKEE 345
E R +R+ R + L ++Q L+ E ++ D K E+ + SR + EE+++
Sbjct: 1380 EQRLRRQERERKFLKEEQQLRCQE-REQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQ 1438
Query: 346 IPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAKTVTGCFVRIGIGNHNSKPVYRVAEI 405
+ + + EE ++R RH+ R + + ++R
Sbjct: 1439 VRRQERERKFLEEEQQLRQERHRKFREEEQL--------------LQEREEQQLHRQERD 1484
Query: 406 TGVVETAKVYQLGGTRTNKGLQLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQ 465
+E + QLR R FR + + +QE E +F++ ++ + Q
Sbjct: 1485 RKFLEEEQ-------------QLRRQERDRKFREQELRSQE-PERKFLEEEQQLHRQQRQ 1530
Query: 466 LPTLDEINKKELSIKEALNYKFNDQD----IEEIVKEKERFRKAPPNYAMKKTQLLKEKA 521
L E +++L +E + D+D EE ++++ ++ +K +L ++K
Sbjct: 1531 RKFLQE--EQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKV 1588
Query: 522 MAEDLGDQDKAKQIQDQLNELEERAEALDRQRTKNISAISYINQRNREWNIVESEKALVA 581
+ +Q++ +Q +E + L ++R + + Q E + E+
Sbjct: 1589 RRQ---EQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER---- 1641
Query: 582 ESHNMKNQQMDPFTRRQCKPTIVSNSRD 609
+ K + +P RRQ + + + RD
Sbjct: 1642 ---DRKFLEEEPQLRRQEREQQLRHDRD 1666
Score = 69.7 bits (169), Expect = 9e-12
Identities = 102/583 (17%), Positives = 234/583 (40%), Gaps = 91/583 (15%)
Query: 65 DQELLSLAKRK-RSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKK 123
+Q+LL + + + + EK Q + E ++E + K++ + R+ + +
Sbjct: 902 EQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYR 961
Query: 124 GTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYG 183
K Q + G + + + E + + +E+ Y
Sbjct: 962 KDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYR 1021
Query: 184 ---------EDLMGDEEDRARLEQMTEKEREQELFNRIE-----------KREVLKRRFE 223
E L+ +E ++ RL++ + RE+E + E +R+ L+R++
Sbjct: 1022 KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081
Query: 224 IKKKLKTAKK---KEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQ 280
+++L+ ++ +E+ EK+++QE E++ ++ ++Q+ + +ER +R ++L+++ +
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141
Query: 281 AMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEE 340
EE++ E E+ E K++ + Y ++EE +++++ + ++ R + +
Sbjct: 1142 EEEEVQQEEEQLLREEPE---KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQ 1198
Query: 341 -EEKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAKTVTGCFVRIGIGNHNSKPV 399
E+EE+ + + +E R L +W P
Sbjct: 1199 YREEEELQRQKRKQRYRDEDQRSDL------KWQWEP----------------------- 1229
Query: 400 YRVAEITGVVETAKVYQLGGT----RTNKGLQLRHGNDQRVFRLEFVSNQE-FTESEFMK 454
E V KVY G R + QLR Q+ + QE E E +
Sbjct: 1230 ----EKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRR 1285
Query: 455 WKEAMFSAGMQLPTLDEINKKELSIKEALNYKFNDQDIEEIV---KEKERFRKAPPNYAM 511
W++ P +++ ++E KEA Q+ ++++ +E++R R+
Sbjct: 1286 WQQ----RDRHFPEEEQLEREEQ--KEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFR 1339
Query: 512 KKTQLLKE-------------KAMAEDLGDQDKAKQI---QDQLNELEERAEALDRQRTK 555
++ QLL+E K E+L Q++ ++ + +L E + L ++
Sbjct: 1340 EEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL 1399
Query: 556 NISAISYINQRNREWNIVESEKALVAESHNMKNQQMDPFTRRQ 598
+++R+ E E+ L + + K ++ + RRQ
Sbjct: 1400 RCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ 1442
Score = 67.8 bits (164), Expect = 3e-11
Identities = 62/341 (18%), Positives = 151/341 (44%), Gaps = 39/341 (11%)
Query: 66 QELLSLAKRKRSDS-EEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGK-------- 116
+E L +R+R+ +E+E + + S+ D +W + + +K+ +
Sbjct: 835 EEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA 894
Query: 117 ----ARKI-----EKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSS 167
RK E++ ++++ + ++ E +E E +
Sbjct: 895 LQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ 954
Query: 168 DSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIE-----------KRE 216
+ + ++ E L+G+E ++ R ++ +K RE+E + E +R+
Sbjct: 955 ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014
Query: 217 VLKRRFEIKKKLKTAKK---KEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDE 273
+R++ K +L+ ++ +E++EK++ QE E++ ++ ++Q+ + +ER ++R +
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQ 1074
Query: 274 KLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSR 333
+L+++ + EEL+ E E+ E K++ + ++EE +++++ + +R R
Sbjct: 1075 ELERQYRKEEELQQEEEQLLREEPE---KRRRQERERQCREEEELQQEEEQLLREEREKR 1131
Query: 334 TSSSDEEEEKEEIPPKSQPVSL----PEELNRVRLSRHKLE 370
E + +EE + + L PE+ R L R E
Sbjct: 1132 RRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYRE 1172
Score = 63.2 bits (152), Expect = 8e-10
Identities = 53/254 (20%), Positives = 114/254 (44%), Gaps = 23/254 (9%)
Query: 120 IEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFH 179
+E++ +++Q + D+ E +EGE + D E+++
Sbjct: 1646 LEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE----EQQLRRQERDRKFREEEQQLR 1701
Query: 180 DGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEK 239
E EE + R +++ K RE+E + ++E L+R+ +K L+ + + ++E+
Sbjct: 1702 RQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREE 1761
Query: 240 KKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAEL 299
++ + +E+++K +E + +E + R ++ D+K + E+L+ ERE+++ R
Sbjct: 1762 QQLRRQERDRK----FREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLR---- 1813
Query: 300 LAKKQPLKTSEVYSDDEE----EEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSL 355
P + Y +EE EE++ + ++ DR R +EK + Q +
Sbjct: 1814 -----PQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSR--REEQELWQ 1866
Query: 356 PEELNRVRLSRHKL 369
EE R + KL
Sbjct: 1867 EEEQKRRQERERKL 1880
Score = 61.2 bits (147), Expect = 3e-09
Identities = 103/549 (18%), Positives = 220/549 (40%), Gaps = 68/549 (12%)
Query: 61 DENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKI 120
+E L+Q L + +R + E E Q A ++ +W S + ++ K
Sbjct: 665 EERLEQRLKREHEEERREQELAEE--EQEQARERIKSRIPKWQWQLESEADARQSKVYSR 722
Query: 121 EKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHD 180
+K G + E E E+ + + + D +
Sbjct: 723 PRK-----------QEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQW 771
Query: 181 GYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKK 240
E E R RL ++E R E+R+ ++RF +++ K ++++++E++
Sbjct: 772 QAEEK---SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE 828
Query: 241 KK------QEEEQEKKKLTQIQESQ-VTSHNKERRSKRDEKLDKKSQAMEELKAEREKRK 293
K+ +E+ Q +++ Q+QE + ++ERR ++++ D+K + +L+ ER++R+
Sbjct: 829 KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWR--WQLEEERKRRR 886
Query: 294 NRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPV 353
+ A ++ L+ + +EEEE + EK R + EEE+ ++
Sbjct: 887 HTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ-------- 938
Query: 354 SLPEELNRVRLSRHKLERWCHMPFFAKTVTGCFVRIGIGNHNSKPVYRVAEITGVVETAK 413
EE +R R K R + K + K + ++ G +
Sbjct: 939 ---EEEQLLREEREKRRRQERERQYRK--------------DKKLQQKEEQLLGEEPEKR 981
Query: 414 VYQLGGTRTNKGLQLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDEIN 473
Q + + +L+ +Q + ++ E ++ K K+ + QL +E
Sbjct: 982 RRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK-KDELQQEEEQL-LREERE 1039
Query: 474 KKELSIKEALNYKFND---QDIEEIV---------KEKERFRKAPPNYAMKKTQLLKEKA 521
K+ L +E Y+ + Q+ E+++ +E ER + ++ QLL+E+
Sbjct: 1040 KRRLQERER-QYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE- 1097
Query: 522 MAEDLGDQDKAKQIQDQLNELEERAEALDRQRTKNISAISYINQRNREWNIVESEKALVA 581
E Q++ +Q +++ EL++ E L R+ + Q E + + E+ L+
Sbjct: 1098 -PEKRRRQERERQCREE-EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155
Query: 582 ESHNMKNQQ 590
E + +Q
Sbjct: 1156 EEPEKRRRQ 1164
Score = 58.2 bits (139), Expect = 3e-08
Identities = 82/422 (19%), Positives = 180/422 (42%), Gaps = 56/422 (13%)
Query: 175 DEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKK 234
D +F + ++L E +R LE+ + R+Q +++ + L+R+ +++ + +K
Sbjct: 1500 DRKFRE---QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK 1556
Query: 235 EKKEKKKKQEEE------QEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAE 288
++E++ +QE E QE+ + +++E +V +ER+ DE+ ++ + ++L+ E
Sbjct: 1557 FREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQE 1616
Query: 289 REKRKNRTAELLAKKQPLKTSEVYSD----DEEEEEDDKSSEKSDRSSRTSSSDEEE--- 341
R+++ +LL +++ + D +EE + + E+ R R EEE
Sbjct: 1617 RDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLL 1676
Query: 342 ---EKEEIPPKSQPVSLPEELNRVR--------------LSRHKLERWCHMPFFAKTVTG 384
E++++ + + EE ++R L R +LER + T
Sbjct: 1677 QEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQET- 1735
Query: 385 CFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGTRTNKGLQLRHGNDQRVFRLEFVSN 444
+ + R ++E QL R + QLR R FR E
Sbjct: 1736 ----------EQEQLRRQERYRKILEEE---QLRPEREEQ--QLRRQERDRKFREEEQLR 1780
Query: 445 QEFTESEFMKWK-EAMFSAGMQLPTLDEINKKELSIKEALNYKFNDQDIEEIVKEKERFR 503
QE E + + + F QL E + ++ Y++ ++ ++ +E+ +
Sbjct: 1781 QEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG-KYRWEEEQLQLEEQEQRLRQ 1839
Query: 504 KAPPNYAMKKTQLLKEKAMAE--DLGDQDKAKQIQDQLNELEE---RAEALDRQRTKNIS 558
+ Y ++ +EK+ E +L +++ K+ Q++ +L E R + + QR + +
Sbjct: 1840 ERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVG 1899
Query: 559 AI 560
I
Sbjct: 1900 EI 1901
Score = 56.6 bits (135), Expect = 8e-08
Identities = 70/337 (20%), Positives = 141/337 (41%), Gaps = 50/337 (14%)
Query: 48 RVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFG 107
R + DS D S ++L Q LL +++R +E+ + + E + +++
Sbjct: 1251 RQLEDSQLRDRQSQQDL-QHLLG-EQQERDREQERRRWQQRDRHFPEEEQLEREEQ---- 1304
Query: 108 SNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSS 167
K K+ + E+K ++++ + +D+ E +E E
Sbjct: 1305 --KEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQERE-----------EQ 1351
Query: 168 DSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKK 227
D +F + E+L E+ R LE+ EQ L + +R+ LK +++ +
Sbjct: 1352 PLRRQERDRKFRE---EELRHQEQGRKFLEE------EQRLRRQERERKFLKEEQQLRCQ 1402
Query: 228 LKTAKKKEKKEKKKKQEEEQ----EKKKLTQIQESQVTSHNKER---------RSKRDEK 274
+ + ++ +++K ++EE+Q E+ + + +E QV +ER R +R K
Sbjct: 1403 EREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK 1462
Query: 275 LDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRT 334
++ Q ++E + ++ R+ R + L ++Q L+ +E D K E+ RS
Sbjct: 1463 FREEEQLLQEREEQQLHRQERDRKFLEEEQQLR---------RQERDRKFREQELRSQEP 1513
Query: 335 SSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLER 371
EEE++ + Q L EE R R + R
Sbjct: 1514 ERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR 1550
Score = 54.7 bits (130), Expect = 3e-07
Identities = 50/196 (25%), Positives = 99/196 (50%), Gaps = 12/196 (6%)
Query: 184 EDLMGDEEDRARLEQMTEKEREQELFNRIEKR--EVLKRRFEIKKKLKTAKKKEKKEKKK 241
E L+ EE++ RLEQ + REQ L E+R ++LKR E +++ +++E+ E++
Sbjct: 547 EQLLKREEEK-RLEQ---ERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRL 602
Query: 242 KQEE----EQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAME-ELKAEREKRKNRT 296
K+EE EQE+++ +++ + +++ K +E+ +++ Q + E + RE+R R
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662
Query: 297 AELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDR-SSRTSSSDEEEEKEEIPPKSQPVSL 355
E +Q LK E+E +++ + +R SR + E E +S+ S
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSR 722
Query: 356 PEELNRVRLSRHKLER 371
P + R + + E+
Sbjct: 723 PRKQEGQRRRQEQEEK 738
Score = 54.3 bits (129), Expect = 4e-07
Identities = 37/166 (22%), Positives = 88/166 (53%), Gaps = 10/166 (6%)
Query: 191 EDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKK 250
E R + E++ E+E+ R+++ E + R + K + +++ +++ +++Q+E +E++
Sbjct: 599 EQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR 658
Query: 251 KLTQIQESQVTSHNKERRSKRDEKLDKKSQ--AMEELKAEREKRKNRTAE---LLAKKQP 305
+ +E ++ E+R KR+ + +++ Q A EE + RE+ K+R + L +
Sbjct: 659 LKREEEEERL-----EQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD 713
Query: 306 LKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQ 351
+ S+VYS ++E + E+ ++ R S + +E+E + Q
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQ 759
Score = 54.3 bits (129), Expect = 4e-07
Identities = 56/227 (24%), Positives = 114/227 (50%), Gaps = 32/227 (14%)
Query: 174 EDEEF-HDGYGEDLMGDEEDRARLE---QMTEKEREQELFNRIEKR-----EVLKRRFEI 224
EDE+ + + L E DR LE Q+ +EREQ+L + +++ ++L+ E
Sbjct: 1623 EDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQ 1682
Query: 225 KKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEE 284
+ + + +K ++E+++ + +E+E+K L +E Q+ ER+ + +E+L ++++ E+
Sbjct: 1683 QLRRQERDRKFREEEQQLRRQERERKFLQ--EEQQLRRQELERKFREEEQLRQETE-QEQ 1739
Query: 285 LKAEREKRKNRTAELL---AKKQPLKTSE---VYSDDE----EEEEDDKSSEKSDRSSRT 334
L+ + RK E L ++Q L+ E + ++E E EE S++SDR R
Sbjct: 1740 LRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFRE 1799
Query: 335 SSS-DEEEEKEEIPP---------KSQPVSLPEELNRVRLSRHKLER 371
+E E++++ P + + + L E+ R+R R + R
Sbjct: 1800 EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR 1846
Score = 53.5 bits (127), Expect = 7e-07
Identities = 52/205 (25%), Positives = 89/205 (43%), Gaps = 34/205 (16%)
Query: 189 DEEDRARL---EQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEE 245
DEE RAR E + + R++E R E R+ R+ E + + +K++++E++ + E
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRD---RQLEEEPGQRRRQKRQEQERELAEGE 152
Query: 246 EQEKKKLTQIQ------------ESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRK 293
EQ +K+ Q + Q +ERR++ ++ K EE E + R+
Sbjct: 153 EQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212
Query: 294 NRTAELLAKKQPLKTSE-------VYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEI 346
EL K + K + V+ ++EE+E R T EEE+ +E
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEW---------RKRETVLRKEEEKLQEE 263
Query: 347 PPKSQPVSLPEELNRVRLSRHKLER 371
P+ Q EE +L R +L R
Sbjct: 264 EPQRQRELQEEEEQLRKLERQELRR 288
Score = 53.1 bits (126), Expect = 9e-07
Identities = 51/220 (23%), Positives = 103/220 (46%), Gaps = 34/220 (15%)
Query: 186 LMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEK--KKKQ 243
L +E + R +Q+ + E ++E + +RE +RR +++LK +++E+ E+ K++
Sbjct: 620 LKREEPEEERRQQLLKSEEQEERRQQQLRREQQERR---EQRLKREEEEERLEQRLKREH 676
Query: 244 EEEQEKKKLTQIQESQVTSHNKERRSKRDEKLD--------------KKSQAMEELKAER 289
EEE+ +++L + ++ Q K R K +L+ +K + + +
Sbjct: 677 EEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQE 736
Query: 290 EKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDD-----KSSEKSDR-----SSRTSSSDE 339
EKR+ R +EL +++ + EEE+ D ++ EKS+R S+R ++
Sbjct: 737 EKRRRRESELQWQEEERAHRQ---QQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQ 793
Query: 340 EEEKEEIPPKSQPVS--LPEELNRVRLSRHKLERWCHMPF 377
E + + Q LPEE + + R + ER + F
Sbjct: 794 RERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQF 833
Score = 48.1 bits (113), Expect = 3e-05
Identities = 36/194 (18%), Positives = 89/194 (45%), Gaps = 9/194 (4%)
Query: 174 EDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKK 233
E+E+ E + +E + +K R QE + + E RR E +++L+ +
Sbjct: 1559 EEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD 1618
Query: 234 K---------EKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEE 284
+ +++E+++ +E+++K L + + + ++ R RD K ++ Q ++E
Sbjct: 1619 RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678
Query: 285 LKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKE 344
+ ++ +R+ R + ++Q L+ E +EE+ + E + +E E+E
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738
Query: 345 EIPPKSQPVSLPEE 358
++ + + + EE
Sbjct: 1739 QLRRQERYRKILEE 1752
Score = 47.4 bits (111), Expect = 5e-05
Identities = 38/184 (20%), Positives = 91/184 (49%), Gaps = 21/184 (11%)
Query: 174 EDEEFHDGYGEDLMGDEEDRA--RLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTA 231
++++ G+ + E DR EQ+ ++ EQ+L + R+ L+ +++++ +
Sbjct: 1600 DEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQ 1659
Query: 232 KKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREK 291
+ + +++K ++EE+ L + +E Q+ RR +RD K ++ Q + +
Sbjct: 1660 QLRHDRDRKFREEEQL----LQEGEEQQL------RRQERDRKFREEEQQL--------R 1701
Query: 292 RKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQ 351
R+ R + L ++Q L+ E+ EEE+ + +E+ ++ R + E+E++ P+ +
Sbjct: 1702 RQERERKFLQEEQQLRRQELERKFREEEQLRQETEQ-EQLRRQERYRKILEEEQLRPERE 1760
Query: 352 PVSL 355
L
Sbjct: 1761 EQQL 1764
Score = 37.7 bits (86), Expect = 0.037
Identities = 30/169 (17%), Positives = 77/169 (45%), Gaps = 27/169 (15%)
Query: 184 EDLMGDEEDRA-RLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKK 242
+ L E DR R E+ +ERE++ E R+F +++L ++++E+++
Sbjct: 1762 QQLRRQERDRKFREEEQLRQEREEQQLRSQES----DRKFREEEQL-----RQEREEQQL 1812
Query: 243 QEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAK 302
+ ++++ K + ++ Q+ + R +RD + + Q + K+ RE++
Sbjct: 1813 RPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQ---------- 1862
Query: 303 KQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQ 351
E++ ++E++ ++ + + R +E+ ++ KSQ
Sbjct: 1863 -------ELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904
Score = 33.5 bits (75), Expect = 0.70
Identities = 35/160 (21%), Positives = 67/160 (41%), Gaps = 20/160 (12%)
Query: 439 LEFVSNQEFTESEFM----KWKEAMFSAGMQLPTLDEINKKELSIKEALNYKFNDQDIEE 494
L+ SN +EF+ K +A + A Q LDE + KE+L ++ +
Sbjct: 61 LDLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQR 120
Query: 495 IVKEKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDKAKQIQDQLNELEERAEALDRQRT 554
+ ++R + P ++ + +E+ +AE G++ KQ + + + + R E L RQR
Sbjct: 121 RFEPRDRQLEEEPGQRRRQKRQEQERELAE--GEEQSEKQERLEQRDRQRRDEELWRQR- 177
Query: 555 KNISAISYINQRNREWNIVESEKALVAESHNMKNQQMDPF 594
+EW E +A + + K + + F
Sbjct: 178 -------------QEWQEREERRAEEEQLQSCKGHETEEF 204
Score = 33.1 bits (74), Expect = 0.91
Identities = 37/161 (22%), Positives = 73/161 (45%), Gaps = 21/161 (13%)
Query: 112 KKKGKARKIEKKGTMKKQANKTA-SSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSD 170
+++ + RK ++ ++++ + S SD+ E +E E + D
Sbjct: 1765 RRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQERE----EQQLRPQQRDGK 1820
Query: 171 SSSEDEEFHDGYGEDLMGDEEDRA-RLEQM---TEKER--EQELFNRIEKREVLKRRFEI 224
E+E+ E + E DR R E+ EK R EQEL+ E+ KRR E
Sbjct: 1821 YRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQ----KRRQER 1876
Query: 225 KKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNK 265
++KL+ ++ +++Q+EEQ +++ +I+ + H +
Sbjct: 1877 ERKLR------EEHIRRQQKEEQRHRQVGEIKSQEGKGHGR 1911
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 72.4 bits (176), Expect = 1e-12
Identities = 66/298 (22%), Positives = 133/298 (44%), Gaps = 33/298 (11%)
Query: 61 DENLDQELLSLAKRKRS-DSEEKEPPVSQPAAS------SDSETSDSDDEWTFGSNKNKK 113
+ L QE + + K KR+ +E+ + Q S+ + + DE + K
Sbjct: 2087 ERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKL 2146
Query: 114 KGKARK-IEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSS 172
K R+ I K+ M ++ +K A S E EE EV ++
Sbjct: 2147 ANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRG 2206
Query: 173 SEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAK 232
+ +E +++ +E +E + ++ +QE + E+ E +
Sbjct: 2207 DKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEE--------------RE 2252
Query: 233 KKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKR 292
++E++E+++ +EEE+E+K+ + +E QV +E++ K+ EK ++ Q EE+ E+E
Sbjct: 2253 EEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKE-- 2310
Query: 293 KNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKS 350
E++++++ +E SD+EEEEE E+ DR +++ + +E KS
Sbjct: 2311 -----EIMSEEE----TESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKS 2359
Score = 59.3 bits (142), Expect = 1e-08
Identities = 46/180 (25%), Positives = 89/180 (49%), Gaps = 17/180 (9%)
Query: 184 EDLMGDEEDR-ARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKK 242
E+ M +EE + AR + E+E IE+ EV+ K++ +K K+ K
Sbjct: 2157 EEKMTEEESKLARKHSEVILDDEEE--GGIEEEEVIP----------FLKRRWRKRKEAK 2204
Query: 243 QEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAK 302
+ ++ ++K +Q+ E + H E ++L+K+ E + ERE+ + R E + +
Sbjct: 2205 RGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVRE 2264
Query: 303 KQPLKTSEVYSDDE--EEEEDDKSSEKSDRSSRTSSSDEE--EEKEEIPPKSQPVSLPEE 358
++ + E +++ E+EE++K +K ++ EE EEKEEI + + SL +E
Sbjct: 2265 EEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDE 2324
Score = 54.7 bits (130), Expect = 3e-07
Identities = 63/267 (23%), Positives = 112/267 (41%), Gaps = 81/267 (30%)
Query: 44 KRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDE 103
++ V++D D E+ G +E +E++ KR+
Sbjct: 2169 RKHSEVILD-DEEEGGIEE---EEVIPFLKRR---------------------------- 2196
Query: 104 WTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSS 163
W + RK K+G K+ SS + +S S E + + + S
Sbjct: 2197 W-----------RKRKEAKRGDKPKE---KFSSQVDEVESEEHFSEEMESLLDELEKQES 2242
Query: 164 SSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFE 223
SS + + E+EE EE+ R E+ KE E+ ++EK E
Sbjct: 2243 LSSEEEEEREEEEE-----------REEEEVREEEEERKEEEEGEEKQVEKEE------- 2284
Query: 224 IKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAME 283
++K+KK+K+KK+EE QEK+++ +E + +E S DE+ +++S ++E
Sbjct: 2285 --------EEKKKKKKEKKKEEVQEKEEV--FEEKEEIMSEEETESLSDEEEEEESCSLE 2334
Query: 284 ELKAEREKRKNRTAELLAKKQPLKTSE 310
E + +REK E+L K++ K E
Sbjct: 2335 E-EVDREK------EILKKEKQFKLQE 2354
Score = 51.2 bits (121), Expect = 3e-06
Identities = 45/179 (25%), Positives = 82/179 (45%), Gaps = 13/179 (7%)
Query: 197 EQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQ---EEEQEKKKLT 253
E+ +E ++++ R +++ K R I K+ K +++ K +K + ++E+E
Sbjct: 2127 EKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGG--- 2183
Query: 254 QIQESQVTSHNKERRSKRDE--KLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEV 311
I+E +V K R KR E + DK + E E ++ + E+ + L+ E
Sbjct: 2184 -IEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQES 2242
Query: 312 YSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLE 370
S +EEEE + E+ +R +EEE KEE + + V EE + + K E
Sbjct: 2243 LSSEEEEERE----EEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKE 2297
Score = 50.1 bits (118), Expect = 7e-06
Identities = 113/575 (19%), Positives = 236/575 (41%), Gaps = 123/575 (21%)
Query: 96 ETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSA---ESSAPEE 152
E S +++ TF + + + +K K G +K++ K S + + A E +E
Sbjct: 1386 EISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQE 1445
Query: 153 GEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRI 212
G++ + S D +E+ +GE T K +
Sbjct: 1446 GKLVMIERTPSWQ----DWKKAWDEWKQVHGE---------------TRKSW------KA 1480
Query: 213 EKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEK-KKLTQIQESQVTSHNKERRSKR 271
K E KR + ++KL A +K E++ QE+++ K ++ Q+ E+ ++S +KE++ K
Sbjct: 1481 WKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKD 1540
Query: 272 DEKL-----------DKKSQAMEELKAEREKRK----NRTAELLAKKQPLKTSEVYSDDE 316
+E++ +K+ Q EE + +E+ K +R KK+ + ++ ++E
Sbjct: 1541 EEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEE 1600
Query: 317 EEEEDDKSSEKSDRS-----SRTSSSDEE---------EEKEEIPPKSQPVSLPEELNRV 362
+ ++++ + +R + + D E +++E + + + +S +E ++
Sbjct: 1601 KLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLS--QEAEKL 1658
Query: 363 RLSRHKL-ERWCHMPFFAKTVTGCFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGTR 421
R KL ++W + + + +K ++AE+ ++ KV +L
Sbjct: 1659 AQKRKKLAKKWEKVAREEEKL-------------AKKGGKLAEVKNIL-AQKVEEL---- 1700
Query: 422 TNKGLQLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDEINKKELSIKE 481
QR L++ + E E ++W ++E++ KE E
Sbjct: 1701 -----------PQREQNLDWQEKELAQELEELEW------------DMEELSWKE----E 1733
Query: 482 ALNYKFNDQDIEEIVKEKERFRKAPPNYAMKKTQLLKEK---AMAEDLGDQDKAKQIQDQ 538
LN Q+ ++V+EK++ + A ++ +L +E+ A E+L Q+K K Q +
Sbjct: 1734 ELN-----QEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHK 1788
Query: 539 LNELEERAEALDRQRTKNISAISYINQRNREW-NIVE---SEKALVAESHNM----KNQQ 590
++ E E L R+R + I + Q+ W N +E K ++ + N+ KN
Sbjct: 1789 -EKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLA 1847
Query: 591 MDPFTRRQCKPTIVSNSRDPAVQAAILAQLNAKYG 625
+ Q K ++ N L Q+ K G
Sbjct: 1848 QEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLG 1882
Score = 50.1 bits (118), Expect = 7e-06
Identities = 109/569 (19%), Positives = 222/569 (39%), Gaps = 59/569 (10%)
Query: 62 ENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIE 121
E L E L + K+ EE + +S E D+E + ++G+ ++ +
Sbjct: 1501 EKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQ 1560
Query: 122 KKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDG 181
+ + + K + AE +E E + + + + E+ +
Sbjct: 1561 VTEEQRHIQEEHKWARIHRKRARAEKKRAQE-ERKLAQEEEKLAQEERQLAQEERKLAQA 1619
Query: 182 YGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKK 241
Y + + D+ + A+ E ++E+ L R EK E +K + KK KK +K
Sbjct: 1620 YVK-ITQDDREMAQAEGKFA-QKEETLAQRGEKLSQ-----EAEKLAQKRKKLAKKWEKV 1672
Query: 242 KQEEEQEKKKLTQIQE-SQVTSHNKERRSKRDEKLD----KKSQAMEELKAEREKRKNRT 296
+EEE+ KK ++ E + + E +R++ LD + +Q +EEL+ + E+ +
Sbjct: 1673 AREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKE 1732
Query: 297 AELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDE--EEEKEEIPPKSQPVS 354
EL ++ L + +EEE + + S+ ++ + +E +EKE++ +
Sbjct: 1733 EELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKE--K 1790
Query: 355 LPEELNRVRLSRHKLERWCHMPFFAKTVTGCFVRIGIGNHNSKPVYRVAEITGVVETAKV 414
+PEE R+ R +L ++ + + + + E+T +
Sbjct: 1791 MPEEEERLGRKREQLIE---------------KKMKLAQKRERWINSMEELT--KNKMIL 1833
Query: 415 YQLGGTRTNKGLQLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDEINK 474
YQ K + + + N+E + + GM L ++ +
Sbjct: 1834 YQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEE 1893
Query: 475 KELSIKEALNYKFND--QDIEEIVKEKERFRKAPPNYAMKKTQLLKEKAMAE-------- 524
K KE + K + +++V+ ++ K A +K +L EKAM +
Sbjct: 1894 KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGE 1953
Query: 525 -DLGDQDKA-----KQIQDQLNELEERAEALDRQRTKNIS---AISYINQRNREWNIVES 575
D+ ++KA K++ ++ L E E L + T S ++ + Q E +
Sbjct: 1954 LDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLE 2013
Query: 576 EKALVAESHNMKNQQMD------PFTRRQ 598
EK L+ E + ++ + FTR Q
Sbjct: 2014 EKILLHEDRILAMEESEIAKGKLEFTRGQ 2042
Score = 45.8 bits (107), Expect = 1e-04
Identities = 58/278 (20%), Positives = 116/278 (41%), Gaps = 13/278 (4%)
Query: 56 EDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNK--- 112
E S +E L+QE L + K+ +EE+E Q S+ ET + +E K K
Sbjct: 1727 ELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQ 1786
Query: 113 -KKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDS 171
K+ + E+ G ++Q + + ++ S + + +
Sbjct: 1787 HKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNL 1846
Query: 172 SSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRI----EKREVLKRRFEIKKK 227
+ E E+ L E +Q+ + + + +FN+I E++ ++ IKKK
Sbjct: 1847 AQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKK 1906
Query: 228 LKTAKKKEK----KEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAME 283
K A+ ++K ++ K++E+ ++K+ E + K R + D ++K+ +E
Sbjct: 1907 EKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLE 1966
Query: 284 ELK-AEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEE 320
+ AE + R E L+K + +TS + E+E
Sbjct: 1967 MKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQE 2004
Score = 45.8 bits (107), Expect = 1e-04
Identities = 112/555 (20%), Positives = 212/555 (38%), Gaps = 114/555 (20%)
Query: 61 DENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKI 120
+E L QE ++ K+K +E ++ V + + + + ++ K +GK R
Sbjct: 1892 EEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLR 1951
Query: 121 EKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHD 180
+ K++ K + E EG+ + S + +S + ++E +
Sbjct: 1952 GELDIAKEEKALNLEM----KRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFE 2007
Query: 181 ---GYGEDLMGDEEDRARLEQMT------EKEREQELFNRIEKREVLKRRFEIKKKLKTA 231
E ++ E+ +E+ E R Q +F + +++ R IKK+ +
Sbjct: 2008 RKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLS 2067
Query: 232 KKKEKKEK--KKKQEEEQEKKKLTQIQESQVTSHN-----KERR-SKRDEKLDKKSQAME 283
K+ K K K Q+ ++++KLTQ +E ++T KERR S KLD K
Sbjct: 2068 KEPAKLNKILKALQKLTRDERKLTQ-EEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFS 2126
Query: 284 ELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEE-- 341
E ++E K + + A K + +++ EE+ K + K S DEEE
Sbjct: 2127 EKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARK---HSEVILDDEEEGG 2183
Query: 342 -EKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAKTVTGCFVRIGIGNHNSKPVY 400
E+EE+ P L R R + +R KP
Sbjct: 2184 IEEEEVIP---------FLKRRWRKRKEAKR-----------------------GDKPKE 2211
Query: 401 RVAEITGVVETAKVYQLGGTRTNKGLQLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMF 460
+ + VE+ + H +++ L+ + QE SE + +E
Sbjct: 2212 KFSSQVDEVESEE----------------HFSEEMESLLDELEKQESLSSEEEEERE--- 2252
Query: 461 SAGMQLPTLDEINKKELSIKEALNYKFNDQDIEEIVKEKERFRKAPPNYAMKKTQLLKEK 520
+E ++E ++E + +++ EE EKE K KK + KEK
Sbjct: 2253 ---------EEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEK-------KKKK--KEK 2294
Query: 521 AMAEDLGDQDKAKQIQDQLNELEERAEALDRQRTKNIS-------AISYINQRNREWNIV 573
K +++Q++ EE+ E + + T+++S + S + +RE I+
Sbjct: 2295 ----------KKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEIL 2344
Query: 574 ESEKALVAESHNMKN 588
+ EK + K+
Sbjct: 2345 KKEKQFKLQEQRRKS 2359
Score = 44.3 bits (103), Expect = 4e-04
Identities = 62/280 (22%), Positives = 126/280 (45%), Gaps = 31/280 (11%)
Query: 61 DENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKI 120
+E L QE LA+ +R ++ + +E + E T K +A K+
Sbjct: 1599 EEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKL 1658
Query: 121 EKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHD 180
+K KK A K + E A + G++++ + + + ++ ++ +
Sbjct: 1659 AQK--RKKLAKKWEKVAREE-----EKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQE 1711
Query: 181 GYGEDLMGD-EEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEK 239
++L + EE +E+++ KE E N+ E + V E KKKL ++ ++
Sbjct: 1712 ---KELAQELEELEWDMEELSWKEEE---LNQEEGKLV-----EEKKKLAEEEEALAWQR 1760
Query: 240 KKKQEEE----QEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEE----LKAEREK 291
+K EEE QE++ L IQE + + +KE+ + +E+L +K + + E L +RE+
Sbjct: 1761 EKLSEEETKLAQEEELL--IQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRER 1818
Query: 292 RKNRTAELLAKKQPLKTSEVYSDDEEE--EEDDKSSEKSD 329
N EL K L + + +++ +E +K +++ +
Sbjct: 1819 WINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKE 1858
Score = 42.7 bits (99), Expect = 0.001
Identities = 60/313 (19%), Positives = 130/313 (41%), Gaps = 52/313 (16%)
Query: 46 KGRVVIDSDTEDSGSDENLDQELLSLA----KRKRSDSEEKEPPVSQPAASSDSETSDSD 101
K + S ++ S+E+ +E+ SL K++ SEE+E + + E + +
Sbjct: 2208 KPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEER-EEEEEREEEEVREEE 2266
Query: 102 DEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSN 161
+E K +++G+ +++EK+ KK+ K + E+ EV +
Sbjct: 2267 EE-----RKEEEEGEEKQVEKEEEEKKKKKK----------EKKKEEVQEKEEVFEEKEE 2311
Query: 162 SSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRR 221
S S E+EE E+ EE+ R +++ +KE++ +L + ++R+ L+ R
Sbjct: 2312 IMSEEETESLSDEEEE------EESCSLEEEVDREKEILKKEKQFKL--QEQRRKSLRGR 2363
Query: 222 FEI-----------KKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSK 270
+ + ++ K +K E ++K + E Q++
Sbjct: 2364 ERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEKQISWE------- 2416
Query: 271 RDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDR 330
DKK+ + E+ + ++ E++ K +P+ + + E + +D K+ S
Sbjct: 2417 -----DKKATVV-EIPRKFLGTMDKEREVMGKYEPIPPHVLGTVLESQAQDLKTPFMSHI 2470
Query: 331 SSRTSSSDEEEEK 343
RT ++E + K
Sbjct: 2471 LRRTVEAEELQHK 2483
Score = 37.4 bits (85), Expect = 0.048
Identities = 49/209 (23%), Positives = 93/209 (44%), Gaps = 24/209 (11%)
Query: 175 DEEFHDGYGEDLMGDEEDRARLEQMTE----KEREQELFNRIEKREVLKRRFEIKKKLKT 230
+EE D++G EE + L++ + + + I K+E K + K+ +
Sbjct: 1346 EEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRK 1405
Query: 231 AKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKL----------DKKSQ 280
A +KE+K K K+E +E++ +++ E T +E+ K++ KL D K
Sbjct: 1406 AVQKERKVGKIKREMTKEERDMSEEVEEMATL--EEKVVKQEGKLVMIERTPSWQDWKKA 1463
Query: 281 AMEELKAEREKRKNRTA-------ELLAKKQPL-KTSEVYSDDEEEEEDDKSSEKSDRSS 332
E + E RK+ A LL +++ L + E S +EE ++DK + +
Sbjct: 1464 WDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQ 1523
Query: 333 RTSSSDEEEEKEEIPPKSQPVSLPEELNR 361
+ + KE+ + V+L EE++R
Sbjct: 1524 VWENMLSSKSKEQQYKDEEEVTLEEEVSR 1552
Score = 30.8 bits (68), Expect = 4.5
Identities = 51/215 (23%), Positives = 95/215 (44%), Gaps = 35/215 (16%)
Query: 61 DENLDQEL-LSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKA-- 117
++ L++ L LS K + S + P S+ +S T + E +K +++G+A
Sbjct: 1031 EQRLNENLTLSHRDEKPAFSLDVSMP-SELKSSLKPPTVSEESEVAIKPSKGQRRGQAGV 1089
Query: 118 RKIEKKGT--MKKQANKTASSGSSD----KDSSAESSAPEEGEVSDSDSNSSSSSSDSDS 171
+K +K +KK + + S++ +D S +AP E E + S SSS+S
Sbjct: 1090 KKHSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKL 1149
Query: 172 SSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTA 231
S +D+ E+D ++ +R Q++ ++ +K+ TA
Sbjct: 1150 S-----------KDVDSQEKDISKDHIALTLKRLQKIRDKRDKKA-------------TA 1185
Query: 232 KKKEKKEKKKKQEEEQEKKKLT-QIQESQVTSHNK 265
+K +KK KKK +E + ++ T + E VT K
Sbjct: 1186 QKLKKKHKKKGKEAKVINEETTPPVMEQPVTKKVK 1220
>gi|4557509 cylicin 2 [Homo sapiens]
Length = 348
Score = 72.0 bits (175), Expect = 2e-12
Identities = 62/243 (25%), Positives = 105/243 (43%), Gaps = 20/243 (8%)
Query: 78 DSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSG 137
DS+ E ++ +T+DS+ E G K+ KKGK IEK K A K + G
Sbjct: 108 DSKAAEIGKKGEDKTTQKDTTDSESELKQGK-KDSKKGK--DIEKGKEEKLDAKKDSKKG 164
Query: 138 SSD----KDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEED- 192
D KDS+ ES + G D+ + S+ DS++E E G +D ++D
Sbjct: 165 KKDAEKGKDSATESEDEKGGAKKDNKKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDS 224
Query: 193 -----------RARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKK 241
+ ++ +++ +++ E ++ K EIKK K KK +
Sbjct: 225 KKGKDSAIELQAVKADEKKDEDGKKDANKGDESKDAKKDAKEIKKGKKDKKKPSSTDSDS 284
Query: 242 KQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLA 301
K + ++E KK +V + E+ S D K D K A ++ K + +K + + A
Sbjct: 285 KDDVKKESKKDATKDAKKVAKKDTEKES-ADSKKDAKKNAKKDAKKDAKKNAKKDEKKDA 343
Query: 302 KKQ 304
KK+
Sbjct: 344 KKK 346
Score = 47.8 bits (112), Expect = 4e-05
Identities = 37/172 (21%), Positives = 75/172 (43%), Gaps = 10/172 (5%)
Query: 183 GEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKK 242
GED ++ ++ + +++ + IEK + + + + KK K KK +K K
Sbjct: 118 GEDKTTQKDTTDSESELKQGKKDSKKGKDIEKGK--EEKLDAKKDSKKGKKDAEKGKDSA 175
Query: 243 QEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAK 302
E E EK + + NK + S + + +K + K +++ +K + + + +
Sbjct: 176 TESEDEKGGAKKDNKKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAI--E 233
Query: 303 KQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVS 354
Q +K DE+++ED K S+ + D +E K+ K +P S
Sbjct: 234 LQAVKA------DEKKDEDGKKDANKGDESKDAKKDAKEIKKGKKDKKKPSS 279
Score = 46.6 bits (109), Expect = 8e-05
Identities = 50/235 (21%), Positives = 92/235 (39%), Gaps = 25/235 (10%)
Query: 32 GRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLD---QELLSLAKRKRSDSEEKEPPVSQ 88
G++G TT + +DS ++++ +E L K + ++ E
Sbjct: 115 GKKGEDKTTQKDTTDSESELKQGKKDSKKGKDIEKGKEEKLDAKKDSKKGKKDAEKGKDS 174
Query: 89 PAASSDSETSDSDDEWTFGSNKNKKKGKARKIE-KKGTMKKQANKTASSGSSDKDSSAES 147
S D + D + NK K A + E +KG +K + K KDS+ E
Sbjct: 175 ATESEDEKGGAKKDNKKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAIEL 234
Query: 148 SAPEEGEVSDSDSNSSSSSSDS--DSSSEDEEFHDGYGEDLMG---DEEDRARLEQMTEK 202
A + E D D ++ D D+ + +E G + D + + +++ ++K
Sbjct: 235 QAVKADEKKDEDGKKDANKGDESKDAKKDAKEIKKGKKDKKKPSSTDSDSKDDVKKESKK 294
Query: 203 EREQELFNRIEKREVLKRRFEIKKKLK-------------TAKKKEKK--EKKKK 242
+ ++ ++ K++ K + KK K AKK EKK +KK K
Sbjct: 295 DATKDA-KKVAKKDTEKESADSKKDAKKNAKKDAKKDAKKNAKKDEKKDAKKKGK 348
Score = 37.4 bits (85), Expect = 0.048
Identities = 46/226 (20%), Positives = 83/226 (36%), Gaps = 58/226 (25%)
Query: 26 EGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPP 85
E GG ++ ++ + +S+ E G++++ +K+ + DS++ +
Sbjct: 179 EDEKGGAKKDNKKDKKDSNKGKDSATESEGEKGGTEKD--------SKKGKKDSKKGKDS 230
Query: 86 VSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSA 145
+ A E D D KK ANK G KD+
Sbjct: 231 AIELQAVKADEKKDEDG------------------------KKDANK----GDESKDAKK 262
Query: 146 ESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKERE 205
++ ++G+ +S+ S S D E + +D D + A+ + TEKE
Sbjct: 263 DAKEIKKGKKDKKKPSSTDSDSKDDVKKESK-------KDATKDAKKVAKKD--TEKESA 313
Query: 206 QELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKK 251
+ + KK K KK+ K+ KK E++ KKK
Sbjct: 314 DS-------------KKDAKKNAKKDAKKDAKKNAKKDEKKDAKKK 346
Score = 34.3 bits (77), Expect = 0.41
Identities = 38/165 (23%), Positives = 65/165 (39%), Gaps = 24/165 (14%)
Query: 184 EDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLK--RRFEIKKKL-KTAKKKEKKEKK 240
E L GD + + + E+ +R+ LK R E+ K + KK E K +
Sbjct: 65 EQLRGDRRQPLWMYRSLMRISERPSVYLAARRQPLKPTRTVEVDSKAAEIGKKGEDKTTQ 124
Query: 241 KKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELL 300
K + + + K + + K + K D K D K K + EK K+ E
Sbjct: 125 KDTTDSESELKQGKKDSKKGKDIEKGKEEKLDAKKDSKKG-----KKDAEKGKDSATE-- 177
Query: 301 AKKQPLKTSEVYSDDEE--EEEDDKSSEKSDRSSRTSSSDEEEEK 343
S+DE+ ++D+K +K + S+++ E EK
Sbjct: 178 ------------SEDEKGGAKKDNKKDKKDSNKGKDSATESEGEK 210
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 70.5 bits (171), Expect = 5e-12
Identities = 70/315 (22%), Positives = 138/315 (43%), Gaps = 21/315 (6%)
Query: 70 SLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSN-KNKKKGKARKIEK-KGTMK 127
S K + E+ + PV + A S + S +E K+ K +A+ EK K +K
Sbjct: 682 SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVK 741
Query: 128 KQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSS-------EDEEFHD 180
++A + S +K + + +PE + ++ S + + S E+
Sbjct: 742 EEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKS 801
Query: 181 GYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKK 240
ED E++ + E++ +E+E ++ +E K+ E +K T K +EKK+ K
Sbjct: 802 PLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEE-EKAPATPKTEEKKDSK 860
Query: 241 KKQEEEQEKKKLTQIQESQVTSHNKERRSK----RDEKLDKKSQAMEELKAE-----REK 291
K++ ++E K +++E + + K + SK ++E DKK E +A +E
Sbjct: 861 KEEAPKKEAPK-PKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKED 919
Query: 292 RKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQ 351
K + +AKK+P ++ + E+ + + EK D + EE+ K E K
Sbjct: 920 AKPKEKTEVAKKEP-DDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKED 978
Query: 352 PVSLPEELNRVRLSR 366
+L +E ++ + +
Sbjct: 979 DKTLSKEPSKPKAEK 993
Score = 70.5 bits (171), Expect = 5e-12
Identities = 68/306 (22%), Positives = 131/306 (42%), Gaps = 32/306 (10%)
Query: 70 SLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQ 129
S K + E+ + PV + A + + S +E K K KA+ ++ K K
Sbjct: 710 SPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEE-AKSPEKAKSPEKAKTLDVKSPEAKT 768
Query: 130 ANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSED----EEFHDGYGED 185
K + +DK ++ +P + EV + S D+ + ++ EE E+
Sbjct: 769 PAKEEARSPADKFPE-KAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEE 827
Query: 186 LMGDE-----------EDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKK 234
E E++A TE++++ + K+E K + E KK+ K K
Sbjct: 828 EKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKK-EEAPKKEAPKPKVEEKKEPAVEKPK 886
Query: 235 EKKEKKKKQEEEQEKKKLTQIQESQVTSHNKE-----------RRSKRDEKLDKKSQAME 283
E K + KK+E E +KK T +E+ KE ++ D K + S+ E
Sbjct: 887 ESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAE 946
Query: 284 ELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEK 343
+ +A EK+ + + ++ KT +D++ + S K++++ ++SS+D+++ K
Sbjct: 947 KKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSK 1006
Query: 344 EEIPPK 349
PP+
Sbjct: 1007 ---PPE 1009
Score = 58.2 bits (139), Expect = 3e-08
Identities = 65/315 (20%), Positives = 136/315 (43%), Gaps = 23/315 (7%)
Query: 76 RSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTAS 135
+S +E K P ++ A ++++ + K++ K+ E K +K++A A
Sbjct: 573 KSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS-PAEAKSPVKEEAKSPAE 631
Query: 136 SGSSDKDSSA---ESSAPEEGEVSDSDSNSSSSSSDSDSSSE---DEEFHDGYGEDLMGD 189
S +K S E+ +PE+ + + + S + S +E E+ +
Sbjct: 632 VKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSP 691
Query: 190 EEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQ-- 247
E+ ++ +++ + + + + E + K + +K++ KT +K + K++ + E+
Sbjct: 692 EKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAK 751
Query: 248 --EKKKLTQIQESQV-TSHNKERRSKRDEKLDK-KSQAMEELKAE-------REKRKNRT 296
EK K ++ + T +E RS D+ +K KS EE+K+ +E K
Sbjct: 752 SPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPE 811
Query: 297 AELLAK---KQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPV 353
E+ K K P+K E + + +E K+ E+ ++ + ++ +KEE P K P
Sbjct: 812 KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPK 871
Query: 354 SLPEELNRVRLSRHK 368
EE + + K
Sbjct: 872 PKVEEKKEPAVEKPK 886
Score = 53.9 bits (128), Expect = 5e-07
Identities = 67/320 (20%), Positives = 134/320 (41%), Gaps = 36/320 (11%)
Query: 66 QELLSLAKRKRSDSEE-KEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKAR-KIEKK 123
+E S K K + EE K P ++ +++++ + K+ +K K+ K E K
Sbjct: 644 EEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAK 703
Query: 124 GTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYG 183
K ++ + S +K S + E + S + S + S E + D
Sbjct: 704 SPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKS 763
Query: 184 EDLM--GDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKK 241
+ EE R+ ++ EK + +E +K + K LK K +KE K
Sbjct: 764 PEAKTPAKEEARSPADKFPEKAKSPV-------KEEVKSPEKAKSPLKEDAKAPEKEIPK 816
Query: 242 KQE-----EEQEKKKLTQIQE---------SQVTSHNKERRSKRDEKLDKKSQAMEELKA 287
K+E +E+EK + +++E + T +E++ + E+ KK +++
Sbjct: 817 KEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEE 876
Query: 288 EREK--RKNRTAELLAKKQPLKTSEVYSDDEEE-------EEDDKSSEKSDRSSRTSSSD 338
++E K + +++ AKK+ + + E+E +ED K EK++ + + D
Sbjct: 877 KKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKK--EPD 934
Query: 339 EEEEKEEIPPKSQPVSLPEE 358
+ + KE P + + PE+
Sbjct: 935 DAKAKEPSKPAEKKEAAPEK 954
Score = 53.1 bits (126), Expect = 9e-07
Identities = 68/312 (21%), Positives = 128/312 (41%), Gaps = 23/312 (7%)
Query: 67 ELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEK-KGT 125
E+ S K K EE + P + A S + E + S ++ K+ K +A+ EK K
Sbjct: 631 EVKSPEKAKSPTKEEAKSP--EKAKSPEKEEAKSPEK-----AKSPVKAEAKSPEKAKSP 683
Query: 126 MKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGED 185
+K +A + S K+ + + ++ S + S + + E+ E+
Sbjct: 684 VKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEE 743
Query: 186 LMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKK--EKKKKQ 243
E+ ++ + T + E K E + +K K+ K+E K EK K
Sbjct: 744 AKSPEKAKSPEKAKTLDVKSPEA-KTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSP 802
Query: 244 EEEQEKKKLTQI-QESQVTSHNKERRSKRDEKLDKKSQAMEELKA----EREKRKNRTAE 298
+E K +I ++ +V S KE ++ K+ + + EE KA + E++K+ E
Sbjct: 803 LKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKE 862
Query: 299 LLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEE 358
KK+ K + EE+ + + EK S + +E E+K+++P + E
Sbjct: 863 EAPKKEAPKP-------KVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVE 915
Query: 359 LNRVRLSRHKLE 370
+ + K E
Sbjct: 916 VKEDAKPKEKTE 927
Score = 48.1 bits (113), Expect = 3e-05
Identities = 51/243 (20%), Positives = 100/243 (41%), Gaps = 19/243 (7%)
Query: 116 KARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSED 175
K + EK ++K +T +++ EE E + + E+
Sbjct: 437 KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEE-----KEAKEEEGKEEEGGEE 491
Query: 176 EEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIE----KREVLKRRFEIK--KKLK 229
EE G E E+ A E+ + ++E + E ++E K E+K +K K
Sbjct: 492 EEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAK 551
Query: 230 TAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDE-KLDKKSQAMEELKAE 288
+ K+E K + + E+E+ K ++V S K + ++E K ++++ E+ K+
Sbjct: 552 SPAKEEAKSPPEAKSPEKEEAK----SPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSP 607
Query: 289 REKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPP 348
++ AE K P+K + + E KS K + S + E+E+ + P
Sbjct: 608 VKEEAKSPAEA---KSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE 664
Query: 349 KSQ 351
K++
Sbjct: 665 KAK 667
Score = 45.8 bits (107), Expect = 1e-04
Identities = 53/238 (22%), Positives = 94/238 (39%), Gaps = 18/238 (7%)
Query: 128 KQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLM 187
K K S+K++ EE +V++ + + + E+E G E+
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEE---GGEEEEAE 495
Query: 188 GDEEDRAR--LEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEE 245
G EE+ E+ E+E + + E + + + K++ K+ + + EK K +
Sbjct: 496 GGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAK 555
Query: 246 EQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQP 305
E E K + + + K EK KS A EE K+ E + A+ K++
Sbjct: 556 E-EAKSPPEAKSPEKEEAKSPAEVKSPEKA--KSPAKEEAKSPAEAKSPEKAKSPVKEEA 612
Query: 306 LKTSEVYSDDEEEEEDD---KSSEKSD-------RSSRTSSSDEEEEKEEIPPKSQPV 353
+E S +EE + KS EK+ +S + S E+EE + PV
Sbjct: 613 KSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPV 670
Score = 42.0 bits (97), Expect = 0.002
Identities = 50/243 (20%), Positives = 97/243 (39%), Gaps = 14/243 (5%)
Query: 62 ENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNK-KKGKARKI 120
+ ++ S K + E+ + P+ + A + + E ++ + + K ++ K ++
Sbjct: 779 DKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEP 838
Query: 121 EKKGTMKKQ--ANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEF 178
KK +K KT S K+ + + AP+ +V + + +S ++ EE
Sbjct: 839 PKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKP-KVEEKKEPAVEKPKESKVEAKKEEA 897
Query: 179 HDGYGEDLMGDE-------EDRARLEQMTE---KEREQELFNRIEKREVLKRRFEIKKKL 228
D E ++ A+ ++ TE KE + K K KK
Sbjct: 898 EDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDT 957
Query: 229 KTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAE 288
K K K+ +EK K + + +E K + S+ + E+ S D+K K + E KA
Sbjct: 958 KEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAA 1017
Query: 289 REK 291
+ K
Sbjct: 1018 KGK 1020
Score = 41.6 bits (96), Expect = 0.003
Identities = 41/217 (18%), Positives = 86/217 (39%), Gaps = 12/217 (5%)
Query: 174 EDEEFHDGYGEDLMGDEEDRARLEQMTE--KEREQELFNRIEKRE----VLKRRFEIKKK 227
E EE G+G E ++ ++ K + +E +EK E +++ + E +
Sbjct: 407 EGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQV 466
Query: 228 LKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKA 287
+ ++E+KE K+++ +E+E + + + + + + + + KS EE K+
Sbjct: 467 TEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKS 526
Query: 288 EREKRKNRTAELLAK---KQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKE 344
E + E + K P K ++ + + KS EK + S E+ K
Sbjct: 527 PAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKS 586
Query: 345 EIPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAKT 381
P + P E ++ ++ P AK+
Sbjct: 587 ---PAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKS 620
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 70.1 bits (170), Expect = 7e-12
Identities = 43/163 (26%), Positives = 83/163 (50%), Gaps = 13/163 (7%)
Query: 189 DEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQE 248
+ +R + ++ EKER++E + +K E +KK + +KK ++EK+ K+ EE+E
Sbjct: 62 ERREREKRKREREKERKRERGKKEKKGE--------RKKEERERKKRRREKENKEGEEKE 113
Query: 249 KKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKT 308
K+K + +E TS + R +++E+ ++ + E K EREK + R +++ +
Sbjct: 114 KRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERER-----KERKKRER 168
Query: 309 SEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQ 351
+V +EE +E ++ K +R E E KE K +
Sbjct: 169 KQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKE 211
Score = 67.0 bits (162), Expect = 6e-11
Identities = 50/184 (27%), Positives = 94/184 (51%), Gaps = 14/184 (7%)
Query: 191 EDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKK 250
E +E E ++E+E + E+RE KR+ E +K+ K + K++K+ ++K+EE + KK
Sbjct: 40 EREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKK 99
Query: 251 KLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSE 310
+ + + + KE+R K+++K ++ + +E K ERE+++ R K++ K E
Sbjct: 100 RRREKENKE--GEEKEKRKKKEKK--ERGRTSKEGK-ERERKEER------KREERKERE 148
Query: 311 VYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPE---ELNRVRLSRH 367
++ E+E + K +K +R +E +EKE K + + E E R
Sbjct: 149 RKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRER 208
Query: 368 KLER 371
K ER
Sbjct: 209 KKER 212
Score = 65.5 bits (158), Expect = 2e-10
Identities = 44/173 (25%), Positives = 91/173 (52%), Gaps = 18/173 (10%)
Query: 202 KEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVT 261
+ERE+E+ R E + K R +KK + ++K K+E++K+++ E+ KK+ ++ +
Sbjct: 39 REREREIETRKEGK---KERESERKKERREREKRKREREKERKRERGKKE----KKGERK 91
Query: 262 SHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTA---ELLAKKQPLKTSEVYSDDEEE 318
+ER+ +R EK +K+ + E+ K + +K + RT+ + +K+ K E + ++
Sbjct: 92 KEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKK 151
Query: 319 EEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLER 371
EE +K E+ +R R E++++ K + E R + R++ ER
Sbjct: 152 EEREKERERKERKKR--------ERKQVGEKEEERKEKERKERKKRERNRKER 196
Score = 63.2 bits (152), Expect = 8e-10
Identities = 44/231 (19%), Positives = 102/231 (44%), Gaps = 20/231 (8%)
Query: 114 KGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSS 173
+ + R+ E++ +K+ K S + E E + + +
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEE 94
Query: 174 EDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKK 233
+ + E+ G+E+++ + ++ E+ R + E++E KR ++
Sbjct: 95 RERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKRE----------ER 144
Query: 234 KEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRK 293
KE++ KK+++E+E+E+K+ + + QV +ER+ K ++ K+ + +E K ERE+++
Sbjct: 145 KERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKE 204
Query: 294 NRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKE 344
R + KK+ +E ++E K + + R + +E K+
Sbjct: 205 RRERKKERKKK----------EERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 63.2 bits (152), Expect = 8e-10
Identities = 39/189 (20%), Positives = 95/189 (50%), Gaps = 8/189 (4%)
Query: 110 KNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDS 169
K +++ + RK E++ K++ K G K+ E E + + +
Sbjct: 61 KERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEK 120
Query: 170 DS---SSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKK 226
+S++ + + E + ++R R ++ EKERE++ + E+++V ++ E K+
Sbjct: 121 KERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKE 180
Query: 227 KLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELK 286
K + +KK ++ +K++++E + K++ +E + KE R K +K D+++ E+ +
Sbjct: 181 KERKERKKRERNRKERKKERERKER----RERKKERKKKEERKKERQK-DRQTNWREKER 235
Query: 287 AEREKRKNR 295
+RE+++ +
Sbjct: 236 GKRERKERK 244
Score = 61.6 bits (148), Expect = 2e-09
Identities = 45/211 (21%), Positives = 92/211 (43%), Gaps = 18/211 (8%)
Query: 85 PVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSS 144
P +QP S+ + + E K ++ + ++ ++ K++ K K+
Sbjct: 28 PCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKK 87
Query: 145 AESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKER 204
E E + + + + E+ G + E + ++ KER
Sbjct: 88 GERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKER 147
Query: 205 EQELFNRIEKREVLKR----RFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQV 260
E++ R ++RE +R R ++ +K + K+KE+KE+KK++ +E+KK
Sbjct: 148 ERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKK--------- 198
Query: 261 TSHNKERRSKRDEKLDKKSQAMEELKAEREK 291
+ER+ +R+ K ++K + EE K ER+K
Sbjct: 199 ---ERERKERRERKKERKKK--EERKKERQK 224
Score = 56.6 bits (135), Expect = 8e-08
Identities = 44/205 (21%), Positives = 96/205 (46%), Gaps = 8/205 (3%)
Query: 75 KRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTA 134
++ +E+E + + + + E K +KKG+ +K E++ KK+ +
Sbjct: 48 RKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERE--RKKRRREKE 105
Query: 135 SSGSSDKDSSAESSAPEEGEVS-DSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDR 193
+ +K+ + E G S + + E E + ++ E +
Sbjct: 106 NKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKK 165
Query: 194 ARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLT 253
+Q+ EKE E++ E++E KR K++ K ++KE++E+KK++++ +E++K
Sbjct: 166 RERKQVGEKEEERK---EKERKERKKRERNRKERKKERERKERRERKKERKK-KEERK-K 220
Query: 254 QIQESQVTSHNKERRSKRDEKLDKK 278
+ Q+ + T+ ++ R KR+ K KK
Sbjct: 221 ERQKDRQTNWREKERGKRERKERKK 245
Score = 36.2 bits (82), Expect = 0.11
Identities = 30/175 (17%), Positives = 76/175 (43%), Gaps = 6/175 (3%)
Query: 73 KRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANK 132
K ++ + +KE + + + + E G K K+K K +K ++G K+ +
Sbjct: 75 KERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKK--ERGRTSKEGKE 132
Query: 133 TASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEED 192
++ E +E + + ++EE + ++ + +
Sbjct: 133 RERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERK--KRE 190
Query: 193 RARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKT--AKKKEKKEKKKKQEE 245
R R E+ E+ER++ + E+++ +R+ E +K +T +K+ K ++K++++
Sbjct: 191 RNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 34.3 bits (77), Expect = 0.41
Identities = 16/89 (17%), Positives = 47/89 (52%), Gaps = 4/89 (4%)
Query: 257 ESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDE 316
+S++ +E ++++ K +++S E K ER +R+ R E +++ + + +
Sbjct: 35 QSEIREREREIETRKEGKKERES----ERKKERREREKRKREREKERKRERGKKEKKGER 90
Query: 317 EEEEDDKSSEKSDRSSRTSSSDEEEEKEE 345
++EE ++ + ++ ++ E+ +K+E
Sbjct: 91 KKEERERKKRRREKENKEGEEKEKRKKKE 119
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 70.1 bits (170), Expect = 7e-12
Identities = 70/304 (23%), Positives = 142/304 (46%), Gaps = 52/304 (17%)
Query: 99 DSDDEWTFGSNKN--KKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVS 156
D D W + ++K + ++ E+K +K+ N S D+DS +S EEGE+
Sbjct: 3 DEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKN------SDDRDSKRDSL--EEGELR 54
Query: 157 D-----SDSNSSSSSSDS--DSSSEDEEFHDGYGEDLMGDEE-----DRARLEQ----MT 200
D + NS DS D ED+ + + E+ D R E+ +
Sbjct: 55 DHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVK 114
Query: 201 EKEREQELFNRI-EKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQ 259
EKERE E R E+++ +R +E +K+ + A++ ++E+ + ++ E+++++ +++E Q
Sbjct: 115 EKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQ 174
Query: 260 VTSHNKERRSKRDEKLDKKSQAMEELKAE-REKRKNRTAELLA----------------- 301
++ R +R E+ K+ +A E+ A R R++ + ++ A
Sbjct: 175 KEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFEL 234
Query: 302 -------KKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVS 354
K++ ++ ++ SD ++ + ++ + ++ SS S S EEE+EE + + S
Sbjct: 235 GDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGS 294
Query: 355 LPEE 358
EE
Sbjct: 295 TSEE 298
Score = 56.2 bits (134), Expect = 1e-07
Identities = 70/342 (20%), Positives = 136/342 (39%), Gaps = 63/342 (18%)
Query: 54 DTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKK 113
D +DS + LD+ L K++R + EEK A + SD D + +
Sbjct: 3 DEKDSWKVKTLDEILQE--KKRRKEQEEK-------AEIKRLKNSDDRDSKRDSLEEGEL 53
Query: 114 KGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSS 173
+ +I + + ++ + G D DS A + + +
Sbjct: 54 RDHCMEITIRNSPYRREDSMEDRGEED-DSLAIKPPQQMSRKEKVHHRKDEKRKEKKHAR 112
Query: 174 EDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKR---EVLKRRFEIKKKLKT 230
E+ + +E+D+AR E +K RE + +R E L+R+ E ++K++
Sbjct: 113 VKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMRE 172
Query: 231 AKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKL--------------- 275
+K+++++K++++ E+ +K+ +E V++H++ R +K+
Sbjct: 173 QQKEQREQKERERRAEERRKEREARRE--VSAHHRTMREDYSDKVKASHWSRSPPRPPRE 230
Query: 276 -----DKKSQAMEELKAERE-----------KRKNRTAELLA----------------KK 303
D + EE ER+ +RK +AE + ++
Sbjct: 231 RFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE 290
Query: 304 QPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEE 345
+ TSE S++EEEEE+++ E S S EE EE
Sbjct: 291 EEGSTSEE-SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEE 331
Score = 52.4 bits (124), Expect = 1e-06
Identities = 55/270 (20%), Positives = 114/270 (42%), Gaps = 22/270 (8%)
Query: 110 KNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSD-SDSNSSSSSSD 168
K +++ K R+ +K+ +K+ + A ++++ E SA D SD +S S
Sbjct: 163 KRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSR 222
Query: 169 SDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKL 228
S E F +GD + E+M E++ +L + + +
Sbjct: 223 SPPRPPRERFE-------LGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAES 275
Query: 229 KTAKKKEKKEKKKKQE-----EEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAME 283
+ ++E++E+++++E EE E+++ + +E + T N E S++ + + E
Sbjct: 276 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAE-----EVSE 330
Query: 284 ELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEK 343
E +E E+R+N L+ + E EE +++ E + +SS + D +
Sbjct: 331 EEMSEDEERENENHLLVVPESRFDR----DSGESEEAEEEVGEGTPQSSALTEGDYVPDS 386
Query: 344 EEIPPKSQPVSLPEELNRVRLSRHKLERWC 373
+ P LP+ L ++ R E C
Sbjct: 387 PALSPIELKQELPKYLPALQGCRSVEEFQC 416
Score = 40.4 bits (93), Expect = 0.006
Identities = 35/182 (19%), Positives = 76/182 (41%), Gaps = 24/182 (13%)
Query: 187 MGDEEDRARL----EQMTEKEREQELFNR------------------IEKREVLKRRFEI 224
MGDE+D ++ E + EK+R +E + +E+ E+ EI
Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
Query: 225 KKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKE--RRSKRDEKLDKKSQAM 282
+ ++++ E + ++++ K Q+ + H K+ R+ K+ ++ +K +
Sbjct: 61 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREH 120
Query: 283 EELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEE 342
E K RE++ E +K+ E + + E + + +R R ++ E+
Sbjct: 121 ERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQ 180
Query: 343 KE 344
KE
Sbjct: 181 KE 182
Score = 39.7 bits (91), Expect = 0.010
Identities = 27/111 (24%), Positives = 47/111 (42%), Gaps = 9/111 (8%)
Query: 106 FGSNKNKKKGKARKIEKKGTMK--------KQANKTASSGSSDKDSSAESSAPEEGEVSD 157
F +K K K+E++ + ++ +A S S++ S +E EE E +
Sbjct: 232 FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE 291
Query: 158 SDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTE-KEREQE 207
S S S + + E+EE E+ + E+M+E +ERE E
Sbjct: 292 EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 342
Score = 32.3 bits (72), Expect = 1.6
Identities = 55/228 (24%), Positives = 90/228 (39%), Gaps = 48/228 (21%)
Query: 53 SDTE-DSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKN 111
SD+E + S E+ E S ++ + + EE+E S S + E + ++E GSN
Sbjct: 259 SDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSN-- 316
Query: 112 KKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDS 171
++ AS S+++ S E S EE E + S D D
Sbjct: 317 -------------------SEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRD- 356
Query: 172 SSEDEEFHDGYGEDLMGDEEDRARLE--------QMTEKEREQEL---------FNRIEK 214
S E EE + GE G + A E ++ E +QEL +E+
Sbjct: 357 SGESEEAEEEVGE---GTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEE 413
Query: 215 REVLKRRFEIKKKLKTAKKKEKKE-----KKKKQEEEQEKKKLTQIQE 257
+ L R E + K +K + K+ K E+E+E +T ++E
Sbjct: 414 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLRE 461
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 70.1 bits (170), Expect = 7e-12
Identities = 67/279 (24%), Positives = 123/279 (44%), Gaps = 24/279 (8%)
Query: 76 RSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTAS 135
RS S S+ S S S + ++ K + +++ KK + ++ K+ S
Sbjct: 313 RSKSRSSSKSHSRRKRSQSKHRSRSHNR---SRSRQKDRRRSKSPHKKRSKSRERRKSRS 369
Query: 136 -SGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRA 194
S S DK E+ V + D + + E E G++ D+E
Sbjct: 370 RSHSRDKRKDTREKIKEKERVKEKD-REKEREREKEREKEKER-----GKNKDRDKEREK 423
Query: 195 RLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQ 254
E+ EK+RE+E ++E K R + K+K + KEK+ +K + +E EK+K +
Sbjct: 424 DREKDKEKDRERE-----REKEHEKDRDKEKEK---EQDKEKEREKDRSKEIDEKRKKDK 475
Query: 255 IQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSD 314
+ S+N RRS+ + ++ ++ + R R ++T + + + P S D
Sbjct: 476 KSRTPPRSYNASRRSRSSSRERRRRRSR---SSSRSPRTSKTIKRKSSRSPSPRSRNKKD 532
Query: 315 DEEEEEDDKSSEKSDRSSRTS---SSDEEEEKEEIPPKS 350
+ E+E D SE+ +R TS SS++ + KE++ S
Sbjct: 533 KKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNS 571
Score = 65.9 bits (159), Expect = 1e-10
Identities = 52/266 (19%), Positives = 111/266 (41%), Gaps = 31/266 (11%)
Query: 118 RKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEE 177
+++ + + A + S S+++ S S S S+S S S S
Sbjct: 280 KRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHN 339
Query: 178 FHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKK 237
+D + + + E+ + + + +KR+ + + + K+++K +++++
Sbjct: 340 RSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKER 399
Query: 238 EKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTA 297
E++K++E+E+E+ K NK+R +R++ +K + E + E+E K+R
Sbjct: 400 EREKEREKEKERGK------------NKDRDKEREKDREKDKEKDREREREKEHEKDR-- 445
Query: 298 ELLAKKQPLKTSEVYSDDEEEEEDDKSSEK-SDRSSRTSSSDEEEEKEEIPPKSQPVSLP 356
D E+E+E DK E+ DRS ++++K PP+S S
Sbjct: 446 ----------------DKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 489
Query: 357 EELNRVRLSRHKLERWCHMPFFAKTV 382
+ R + P +KT+
Sbjct: 490 SRSSSRERRRRRSRSSSRSPRTSKTI 515
Score = 64.3 bits (155), Expect = 4e-10
Identities = 55/249 (22%), Positives = 104/249 (41%), Gaps = 14/249 (5%)
Query: 121 EKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHD 180
E+KG + ++ S SS S + S + S + S S S +
Sbjct: 302 ERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKS 361
Query: 181 GYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKK 240
R + + EK +E+E R+++++ K R K++ K ++ + K++
Sbjct: 362 RERRKSRSRSHSRDKRKDTREKIKEKE---RVKEKDREKEREREKEREKEKERGKNKDRD 418
Query: 241 KKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELL 300
K++E+++EK K + + H K+R +++++ DK E+E+ K+R+ E+
Sbjct: 419 KEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDK----------EKEREKDRSKEID 468
Query: 301 AKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRT-SSSDEEEEKEEIPPKSQPVSLPEEL 359
K++ K S +SS + R R+ SSS + I KS P
Sbjct: 469 EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 528
Query: 360 NRVRLSRHK 368
N+ R K
Sbjct: 529 NKKDKKREK 537
Score = 61.6 bits (148), Expect = 2e-09
Identities = 71/352 (20%), Positives = 137/352 (38%), Gaps = 43/352 (12%)
Query: 9 RAAAAAAAVAVPLAGGQEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQEL 68
R A + + A+ G+ GGR SR T K R + S S Q
Sbjct: 283 REAQSFISAAIEPESGKSNERKGGR--SRSHTRSKSRS--------SSKSHSRRKRSQSK 332
Query: 69 LSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKK 128
RS S +K+ S+ S++ + + +++K+K KI++K +K+
Sbjct: 333 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 392
Query: 129 QANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSS---SSDSDSSSEDEEFHDGYGED 185
+ + +++ E G+ D D + D E E+ H+
Sbjct: 393 KDREKEREREKEREKEKE-----RGKNKDRDKEREKDREKDKEKDREREREKEHEK---- 443
Query: 186 LMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEE 245
D + EQ EKERE++ +E+ ++R + KK + + +
Sbjct: 444 ---DRDKEKEKEQDKEKEREKD-----RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSR 495
Query: 246 EQEKKKLTQIQESQVTSHNKERRSKRD------EKLDKKSQAMEELKAEREKRKNRTAEL 299
E+ +++ S TS +R+S R K DKK + + +ER +R+ T+
Sbjct: 496 ERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTS-- 553
Query: 300 LAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQ 351
K+S E+ E++ S ++ + + SS +E ++ P+++
Sbjct: 554 -----MRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTE 600
Score = 32.3 bits (72), Expect = 1.6
Identities = 30/142 (21%), Positives = 58/142 (40%), Gaps = 3/142 (2%)
Query: 231 AKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAERE 290
A KE +E K+ E Q ES ++ K RS+ + +S + + +R
Sbjct: 270 AAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRS 329
Query: 291 KRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEE-KEEIPPK 349
+ K+R+ + + + ++ KS E+ SR+ S D+ ++ +E+I K
Sbjct: 330 QSKHRSRS--HNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEK 387
Query: 350 SQPVSLPEELNRVRLSRHKLER 371
+ E R R + E+
Sbjct: 388 ERVKEKDREKEREREKEREKEK 409
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 70.1 bits (170), Expect = 7e-12
Identities = 67/279 (24%), Positives = 123/279 (44%), Gaps = 24/279 (8%)
Query: 76 RSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTAS 135
RS S S+ S S S + ++ K + +++ KK + ++ K+ S
Sbjct: 197 RSKSRSSSKSHSRRKRSQSKHRSRSHNR---SRSRQKDRRRSKSPHKKRSKSRERRKSRS 253
Query: 136 -SGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRA 194
S S DK E+ V + D + + E E G++ D+E
Sbjct: 254 RSHSRDKRKDTREKIKEKERVKEKD-REKEREREKEREKEKER-----GKNKDRDKEREK 307
Query: 195 RLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQ 254
E+ EK+RE+E ++E K R + K+K + KEK+ +K + +E EK+K +
Sbjct: 308 DREKDKEKDRERE-----REKEHEKDRDKEKEK---EQDKEKEREKDRSKEIDEKRKKDK 359
Query: 255 IQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSD 314
+ S+N RRS+ + ++ ++ + R R ++T + + + P S D
Sbjct: 360 KSRTPPRSYNASRRSRSSSRERRRRRSR---SSSRSPRTSKTIKRKSSRSPSPRSRNKKD 416
Query: 315 DEEEEEDDKSSEKSDRSSRTS---SSDEEEEKEEIPPKS 350
+ E+E D SE+ +R TS SS++ + KE++ S
Sbjct: 417 KKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNS 455
Score = 65.9 bits (159), Expect = 1e-10
Identities = 52/266 (19%), Positives = 111/266 (41%), Gaps = 31/266 (11%)
Query: 118 RKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEE 177
+++ + + A + S S+++ S S S S+S S S S
Sbjct: 164 KRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHN 223
Query: 178 FHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKK 237
+D + + + E+ + + + +KR+ + + + K+++K +++++
Sbjct: 224 RSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKER 283
Query: 238 EKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTA 297
E++K++E+E+E+ K NK+R +R++ +K + E + E+E K+R
Sbjct: 284 EREKEREKEKERGK------------NKDRDKEREKDREKDKEKDREREREKEHEKDR-- 329
Query: 298 ELLAKKQPLKTSEVYSDDEEEEEDDKSSEK-SDRSSRTSSSDEEEEKEEIPPKSQPVSLP 356
D E+E+E DK E+ DRS ++++K PP+S S
Sbjct: 330 ----------------DKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 373
Query: 357 EELNRVRLSRHKLERWCHMPFFAKTV 382
+ R + P +KT+
Sbjct: 374 SRSSSRERRRRRSRSSSRSPRTSKTI 399
Score = 64.3 bits (155), Expect = 4e-10
Identities = 55/249 (22%), Positives = 104/249 (41%), Gaps = 14/249 (5%)
Query: 121 EKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHD 180
E+KG + ++ S SS S + S + S + S S S +
Sbjct: 186 ERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKS 245
Query: 181 GYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKK 240
R + + EK +E+E R+++++ K R K++ K ++ + K++
Sbjct: 246 RERRKSRSRSHSRDKRKDTREKIKEKE---RVKEKDREKEREREKEREKEKERGKNKDRD 302
Query: 241 KKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELL 300
K++E+++EK K + + H K+R +++++ DK E+E+ K+R+ E+
Sbjct: 303 KEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDK----------EKEREKDRSKEID 352
Query: 301 AKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRT-SSSDEEEEKEEIPPKSQPVSLPEEL 359
K++ K S +SS + R R+ SSS + I KS P
Sbjct: 353 EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 412
Query: 360 NRVRLSRHK 368
N+ R K
Sbjct: 413 NKKDKKREK 421
Score = 61.6 bits (148), Expect = 2e-09
Identities = 71/352 (20%), Positives = 137/352 (38%), Gaps = 43/352 (12%)
Query: 9 RAAAAAAAVAVPLAGGQEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQEL 68
R A + + A+ G+ GGR SR T K R + S S Q
Sbjct: 167 REAQSFISAAIEPESGKSNERKGGR--SRSHTRSKSRS--------SSKSHSRRKRSQSK 216
Query: 69 LSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKK 128
RS S +K+ S+ S++ + + +++K+K KI++K +K+
Sbjct: 217 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 276
Query: 129 QANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSS---SSDSDSSSEDEEFHDGYGED 185
+ + +++ E G+ D D + D E E+ H+
Sbjct: 277 KDREKEREREKEREKEKE-----RGKNKDRDKEREKDREKDKEKDREREREKEHEK---- 327
Query: 186 LMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEE 245
D + EQ EKERE++ +E+ ++R + KK + + +
Sbjct: 328 ---DRDKEKEKEQDKEKEREKD-----RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSR 379
Query: 246 EQEKKKLTQIQESQVTSHNKERRSKRD------EKLDKKSQAMEELKAEREKRKNRTAEL 299
E+ +++ S TS +R+S R K DKK + + +ER +R+ T+
Sbjct: 380 ERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTS-- 437
Query: 300 LAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQ 351
K+S E+ E++ S ++ + + SS +E ++ P+++
Sbjct: 438 -----MRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTE 484
Score = 32.3 bits (72), Expect = 1.6
Identities = 30/142 (21%), Positives = 58/142 (40%), Gaps = 3/142 (2%)
Query: 231 AKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAERE 290
A KE +E K+ E Q ES ++ K RS+ + +S + + +R
Sbjct: 154 AAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRS 213
Query: 291 KRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEE-KEEIPPK 349
+ K+R+ + + + ++ KS E+ SR+ S D+ ++ +E+I K
Sbjct: 214 QSKHRSRS--HNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEK 271
Query: 350 SQPVSLPEELNRVRLSRHKLER 371
+ E R R + E+
Sbjct: 272 ERVKEKDREKEREREKEREKEK 293
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 69.7 bits (169), Expect = 9e-12
Identities = 95/494 (19%), Positives = 214/494 (43%), Gaps = 68/494 (13%)
Query: 118 RKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEE 177
RK+E+ + Q A + K+ + S A + +V +++ + + + EE
Sbjct: 249 RKLERAKLLLPQQQLQAEADHLGKELQSVS-AKLQAQVEENELWNRLNQQQEEKMWRQEE 307
Query: 178 FHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRI------EKREVLKRRFEI--KKKLK 229
+ E + EE ++ + EK REQE R EK E ++R+ E+ +K+ K
Sbjct: 308 KIQEWEEKIQEQEE---KIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 364
Query: 230 TAKKKE---KKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELK 286
+++E +KE+K +++EE +K +I+E + H +E+ +++EK + EE
Sbjct: 365 MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE-----EEKI 419
Query: 287 AEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEI 346
E+EKR+ + A++ +++ ++ E E+E++ + EK + ++ +E+EE+
Sbjct: 420 REQEKRQEQEAKMWRQEEKIREQEE-KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEM 478
Query: 347 PPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAKTVTGCFVRIGIGNHNSKPVYRVAEIT 406
+ + + EE+ R + H+ E
Sbjct: 479 WRQEEKIHEQEEIWRQKEKMHEQEEKIRK------------------------------- 507
Query: 407 GVVETAKVYQLGGTRTNKGLQLRHGNDQRVFRLEFVSNQE--FTESEFMKWKEAMFSAGM 464
+ KV++ + ++R ++ + E + QE + E E M +E ++
Sbjct: 508 ---QEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEK 564
Query: 465 QLPTLDEINKKELSIKEALNYKFNDQDIEEIVKEKERFRKAPPNYAMKKTQLLK---EKA 521
+ D++ ++E I+E + EE ++E+E R+ K+ + ++ EK
Sbjct: 565 RQEQEDKMWRQEEKIREQEEKVWRQ---EEKIREQEEKRQEQEEKMWKQEEKIREQEEKI 621
Query: 522 MAEDLGDQDKAKQIQDQLNELEERAEALDRQRTKNISAISYINQR-----NREWNIVESE 576
++ +++ ++I++Q +E+ E + Q K + ++ +E I E E
Sbjct: 622 QEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQE 681
Query: 577 KALVAESHNMKNQQ 590
K + + ++ Q+
Sbjct: 682 KKIREQEEKIREQE 695
Score = 58.9 bits (141), Expect = 2e-08
Identities = 51/296 (17%), Positives = 146/296 (49%), Gaps = 27/296 (9%)
Query: 80 EEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSS 139
EE++ + + + + ++ W ++++ K RK E+K + +Q K
Sbjct: 468 EEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEK--VWRQEEKIREQEEK 525
Query: 140 DKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDG---YGEDLMGDEEDRARL 196
++ + EE + E+E+ H+ + E+ ++ED+
Sbjct: 526 IREQEEKMWRQEE-----------KIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWR 574
Query: 197 EQMTEKEREQELFNRIEK-REVLKRRFEIKKKLKTAKKKEK-KEKKKKQEEEQEKKKLTQ 254
++ +E+E++++ + EK RE ++R E ++K+ K++EK +E+++K +E++EK + +
Sbjct: 575 QEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMW--KQEEKIREQEEKIQEQEEKIREQE 632
Query: 255 ---IQESQVTSHNKERRSKRDEKLDKKSQAMEE----LKAEREKRKNRTAELLAKKQPLK 307
++ ++T +E+ +++EK+ ++ + M+E + + EK + + ++ +++ ++
Sbjct: 633 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIR 692
Query: 308 TSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVR 363
E ++EE+ ++ + ++ + +E+ ++E Q V L ++ +++
Sbjct: 693 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748
Score = 57.4 bits (137), Expect = 5e-08
Identities = 52/268 (19%), Positives = 123/268 (45%), Gaps = 30/268 (11%)
Query: 112 KKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSS---D 168
+K+ K R++E+K M +Q +K E EE ++ + + +
Sbjct: 388 EKEEKIRELEEK--MHEQ----------EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 435
Query: 169 SDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEI---K 225
+ E EE + + EE E++ E+E+ QE + E + + EI K
Sbjct: 436 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK 495
Query: 226 KKLKTAKKK-EKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEE 284
+K+ ++K K+E+K ++EE+ +++ +I+E + +E + + E++ ++ + M E
Sbjct: 496 EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHE 555
Query: 285 LKA--EREKRKNRTAELLAKKQPLKTSE---------VYSDDEEEEEDDKSSEKSDRSSR 333
+ E EKR+ + ++ +++ ++ E + +E+ +E ++ K + R
Sbjct: 556 QEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIR 615
Query: 334 TSSSDEEEEKEEIPPKSQPVSLPEELNR 361
+E++E+I + + + EE+ +
Sbjct: 616 EQEEKIQEQEEKIREQEEKIREQEEMTQ 643
Score = 57.4 bits (137), Expect = 5e-08
Identities = 45/190 (23%), Positives = 94/190 (49%), Gaps = 7/190 (3%)
Query: 184 EDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQ 243
E++ +EE E++ E+E+ QE +++ ++E R E K + K +E++EK+++Q
Sbjct: 544 EEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQ 603
Query: 244 EEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKK 303
EE+ K++ +I+E + +E + + E +K + EE+ E+E++ E + ++
Sbjct: 604 EEKMWKQE-EKIREQEEKIQEQEEKIREQE---EKIREQEEMTQEQEEKMGEQEEKMCEQ 659
Query: 304 QPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPK--SQPVSLPEELNR 361
+ K E +EE + EK R ++EE +E K Q + E+ +
Sbjct: 660 EE-KMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 718
Query: 362 VRLSRHKLER 371
++ K+ R
Sbjct: 719 MQEQEEKMRR 728
Score = 53.1 bits (126), Expect = 9e-07
Identities = 58/325 (17%), Positives = 140/325 (43%), Gaps = 18/325 (5%)
Query: 61 DENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKI 120
+E + ++ + +++ E++E Q + E E + K + + +
Sbjct: 313 EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMM 372
Query: 121 -EKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSS-EDEEF 178
EK+ M++Q +K E E+ ++ + + + +++E
Sbjct: 373 WEKEEKMRRQEEMMWEK--EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA 430
Query: 179 HDGYGEDLMGDEEDRARLEQ-----MTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKK 233
E+ + ++E++ R ++ EK EQE EKR+ + + ++K+ ++
Sbjct: 431 KMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEE 490
Query: 234 K-EKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKL---DKKSQAMEELKAER 289
+KEK +QEE+ K++ ++ + +E+ +++EK+ ++K + EE+ E
Sbjct: 491 IWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREE 550
Query: 290 EKRKNRTAELLAKKQPLKTSEVYSDDE---EEEEDDKSSEKSDRSSRTSSSDEEEE--KE 344
EK + +K+ + +++ +E E+EE E+ R ++EE+ K+
Sbjct: 551 EKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ 610
Query: 345 EIPPKSQPVSLPEELNRVRLSRHKL 369
E + Q + E+ ++R K+
Sbjct: 611 EEKIREQEEKIQEQEEKIREQEEKI 635
Score = 50.8 bits (120), Expect = 4e-06
Identities = 41/277 (14%), Positives = 126/277 (45%), Gaps = 23/277 (8%)
Query: 110 KNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSA-----ESSAPEEGEVSDSDSNSSS 164
+ K + + ++ E++ M +Q K ++ E E+ ++ + +
Sbjct: 416 EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQ 475
Query: 165 SSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEK-REVLKRRFE 223
E+ ++ M ++E++ R ++ +E+++ + EK RE ++ +
Sbjct: 476 EEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWR 535
Query: 224 IKKKLKTAKKKEKKEKKKKQEE---EQEKKKLTQ----IQESQVTSHN----------KE 266
++K++ ++ ++E+K ++E E+EK++ + QE ++ +E
Sbjct: 536 QEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIRE 595
Query: 267 RRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSE 326
+ KR E+ +K + E+++ + EK + + ++ +++ ++ E + ++EE+ ++ +
Sbjct: 596 QEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEK 655
Query: 327 KSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVR 363
++ + +E ++E + Q + E+ ++R
Sbjct: 656 MCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIR 692
Score = 43.9 bits (102), Expect = 5e-04
Identities = 40/238 (16%), Positives = 100/238 (42%), Gaps = 16/238 (6%)
Query: 73 KRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANK 132
+ K + EEK + + + + ++ W + +K + KI ++ ++Q +K
Sbjct: 516 EEKIREQEEKIREQEEKMWRQEEKIREQEEMW----REEEKMHEQEKIWEEEKRQEQEDK 571
Query: 133 TASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSS---DSDSSSEDEEFHDGYGEDLMGD 189
++ + EE + + E EE E +
Sbjct: 572 MWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQ 631
Query: 190 EEDRARLEQMTEKEREQ---------ELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKK 240
EE E+MT+++ E+ E +++++E R E K + + K +E++EK
Sbjct: 632 EEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKI 691
Query: 241 KKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAE 298
++QEE ++++ ++ + +E+ +++EK+ ++ + M E + +++ + E
Sbjct: 692 REQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 68.9 bits (167), Expect = 2e-11
Identities = 64/315 (20%), Positives = 141/315 (44%), Gaps = 20/315 (6%)
Query: 54 DTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETS-DSDDEWTFGSN--- 109
D +DS + LD+ L ++KR +E++ + + S D ++ DS +E +
Sbjct: 3 DEKDSWKVKTLDE---ILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCME 59
Query: 110 ---KNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSS 166
+N + +E +G S K+ + E S+S+
Sbjct: 60 ITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGG 119
Query: 167 SDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKR---EVLKRRFE 223
+ + E + E E+D+AR E +K RE + +R E L+R+ E
Sbjct: 120 KHARVKEREHERRKRHRE-----EQDKARREWERQKRREMAREHSRRERDRLEQLERKRE 174
Query: 224 IKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAME 283
++K++ +K+++++K++++ E+ +K+ +E V++H++ R +K+ +
Sbjct: 175 RERKMREQQKEQREQKERERRAEERRKEREARRE--VSAHHRTMREDYSDKVKASHWSRS 232
Query: 284 ELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEK 343
+ RE+ + K++ ++ ++ SD ++ + ++ + ++ SS S S EEE+
Sbjct: 233 PPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEE 292
Query: 344 EEIPPKSQPVSLPEE 358
EE + + S EE
Sbjct: 293 EEEEEEEEEGSTSEE 307
Score = 52.4 bits (124), Expect = 1e-06
Identities = 65/339 (19%), Positives = 137/339 (40%), Gaps = 24/339 (7%)
Query: 43 KKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEE--KEPPVSQPAASSDSETSDS 100
+KRK + S + + G + + KR R + ++ +E + + +
Sbjct: 103 EKRKEKCRHHSHSAEGGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 162
Query: 101 DDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSD-SD 159
D K +++ K R+ +K+ +K+ + A ++++ E SA D SD
Sbjct: 163 RDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSD 222
Query: 160 SNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLK 219
+S S S E F +GD + E+M E++ +L + +
Sbjct: 223 KVKASHWSRSPPRPPRERFE-------LGDGRKPVKEEKMEERDLLSDLQDISDSERKTS 275
Query: 220 RRFEIKKKLKTAKKKEKKEKKKKQE-----EEQEKKKLTQIQESQVTSHNKERRSKRDEK 274
+ + ++E++E+++++E EE E+++ + +E + T N E S++ +
Sbjct: 276 SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAE 335
Query: 275 LDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRT 334
+ EE +E E+R+N L+ + E EE +++ E + +SS
Sbjct: 336 -----EVSEEEMSEDEERENENHLLVVPESRFDR----DSGESEEAEEEVGEGTPQSSAL 386
Query: 335 SSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWC 373
+ D + + P LP+ L ++ R E C
Sbjct: 387 TEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQC 425
Score = 36.2 bits (82), Expect = 0.11
Identities = 34/169 (20%), Positives = 71/169 (42%), Gaps = 18/169 (10%)
Query: 187 MGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEE 246
MGDE+D +++ + E +E+ ++R+ + + EIK+ + + K++ ++ E
Sbjct: 1 MGDEKDSWKVKTLDEILQEK------KRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELR 54
Query: 247 QEKKKLTQIQESQVTSHNKERRSKRDEKL-----------DKKSQAMEELKAEREKRKNR 295
++T + E R + D+ L +K +E + E+ + +
Sbjct: 55 DHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSH 114
Query: 296 TAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKE 344
+AE K +K E EE DK+ + +R R + E +E
Sbjct: 115 SAE-GGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 162
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 68.6 bits (166), Expect = 2e-11
Identities = 67/303 (22%), Positives = 140/303 (46%), Gaps = 51/303 (16%)
Query: 99 DSDDEWTFGSNKN--KKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVS 156
D D W + ++K + ++ E+K +K+ N S D+DS +S EEGE+
Sbjct: 3 DEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKN------SDDRDSKRDSL--EEGELR 54
Query: 157 D-----SDSNSSSSSSDS--DSSSEDEEFHDGYGEDLMG--------DEEDRARLEQMTE 201
D + NS DS D ED+ + + DE+ + + +
Sbjct: 55 DHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARV 114
Query: 202 KEREQELFNRI-EKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQV 260
KERE E R E+++ +R +E +K+ + A++ ++E+ + ++ E+++++ +++E Q
Sbjct: 115 KEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQK 174
Query: 261 TSHNKERRSKRDEKLDKKSQAMEELKAE-REKRKNRTAELLA------------------ 301
++ R +R E+ K+ +A E+ A R R++ + ++ A
Sbjct: 175 EQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG 234
Query: 302 ------KKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSL 355
K++ ++ ++ SD ++ + ++ + ++ SS S S EEE+EE + + S
Sbjct: 235 DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGST 294
Query: 356 PEE 358
EE
Sbjct: 295 SEE 297
Score = 53.1 bits (126), Expect = 9e-07
Identities = 73/346 (21%), Positives = 139/346 (40%), Gaps = 72/346 (20%)
Query: 54 DTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKK 113
D +DS + LD+ L K++R + EEK A + SD D + +
Sbjct: 3 DEKDSWKVKTLDEILQE--KKRRKEQEEK-------AEIKRLKNSDDRDSKRDSLEEGEL 53
Query: 114 KGKARKIEKKGTMKKQANKTASSGSSDKDSSA----ESSAPEEGEVSDSDSNSSSSSSDS 169
+ +I + + ++ + G D DS A + + +E D +
Sbjct: 54 RDHCMEITIRNSPYRREDSMEDRGEED-DSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHA 112
Query: 170 DSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKR---EVLKRRFEIKK 226
+ E + E E+D+AR E +K RE + +R E L+R+ E ++
Sbjct: 113 RVKEREHERRKRHRE-----EQDKARREWERQKRREMAREHSRRERDRLEQLERKRERER 167
Query: 227 KLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKL----------- 275
K++ +K+++++K++++ E+ +K+ +E V++H++ R +K+
Sbjct: 168 KMREQQKEQREQKERERRAEERRKEREARRE--VSAHHRTMREDYSDKVKASHWSRSPPR 225
Query: 276 ---------DKKSQAMEELKAERE-----------KRKNRTAELLA-------------- 301
D + EE ER+ +RK +AE +
Sbjct: 226 PPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE 285
Query: 302 --KKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEE 345
+++ TSE S++EEEEE+++ E S S EE EE
Sbjct: 286 EEEEEEGSTSEE-SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEE 330
Score = 51.6 bits (122), Expect = 2e-06
Identities = 55/270 (20%), Positives = 114/270 (42%), Gaps = 22/270 (8%)
Query: 110 KNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSD-SDSNSSSSSSD 168
K +++ K R+ +K+ +K+ + A ++++ E SA D SD +S S
Sbjct: 162 KRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSR 221
Query: 169 SDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKL 228
S E F +GD + E+M E++ +L + + +
Sbjct: 222 SPPRPPRERFE-------LGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAES 274
Query: 229 KTAKKKEKKEKKKKQE-----EEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAME 283
+ ++E++E+++++E EE E+++ + +E + T N E S++ + + E
Sbjct: 275 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAE-----EVSE 329
Query: 284 ELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEK 343
E +E E+R+N L+ + E EE +++ E + +SS + D +
Sbjct: 330 EEMSEDEERENENHLLVVPESRFDR----DSGESEEAEEEVGEGTPQSSALTEGDYVPDS 385
Query: 344 EEIPPKSQPVSLPEELNRVRLSRHKLERWC 373
+ P LP+ L ++ R E C
Sbjct: 386 PALLPIELKQELPKYLPALQGCRSVEEFQC 415
Score = 40.4 bits (93), Expect = 0.006
Identities = 33/158 (20%), Positives = 66/158 (41%), Gaps = 6/158 (3%)
Query: 187 MGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEE 246
MGDE+D +++ + E +E+ ++R+ + + EIK+ + + K++ ++ E
Sbjct: 1 MGDEKDSWKVKTLDEILQEK------KRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELR 54
Query: 247 QEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPL 306
++T + E R + D+ L K K + RK+ + K +
Sbjct: 55 DHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARV 114
Query: 307 KTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKE 344
K E EE DK+ + +R R + E +E
Sbjct: 115 KEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 152
Score = 39.7 bits (91), Expect = 0.010
Identities = 27/111 (24%), Positives = 47/111 (42%), Gaps = 9/111 (8%)
Query: 106 FGSNKNKKKGKARKIEKKGTMK--------KQANKTASSGSSDKDSSAESSAPEEGEVSD 157
F +K K K+E++ + ++ +A S S++ S +E EE E +
Sbjct: 231 FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE 290
Query: 158 SDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTE-KEREQE 207
S S S + + E+EE E+ + E+M+E +ERE E
Sbjct: 291 EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 341
Score = 31.6 bits (70), Expect = 2.7
Identities = 55/228 (24%), Positives = 89/228 (39%), Gaps = 48/228 (21%)
Query: 53 SDTE-DSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKN 111
SD+E + S E+ E S ++ + + EE+E S S + E + ++E GSN
Sbjct: 258 SDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSN-- 315
Query: 112 KKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDS 171
++ AS S+++ S E S EE E + S D D
Sbjct: 316 -------------------SEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRD- 355
Query: 172 SSEDEEFHDGYGEDLMGDEEDRARLE--------QMTEKEREQEL---------FNRIEK 214
S E EE + GE G + A E + E +QEL +E+
Sbjct: 356 SGESEEAEEEVGE---GTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEE 412
Query: 215 REVLKRRFEIKKKLKTAKKKEKKE-----KKKKQEEEQEKKKLTQIQE 257
+ L R E + K +K + K+ K E+E+E +T ++E
Sbjct: 413 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLRE 460
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 68.6 bits (166), Expect = 2e-11
Identities = 63/335 (18%), Positives = 151/335 (45%), Gaps = 29/335 (8%)
Query: 65 DQELLSLAKRKRSDSE--EKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEK 122
D+ L +R R + E+ + + + E D E + ++ + + E+
Sbjct: 403 DERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREE 462
Query: 123 KGTMKKQANKTASSGSS----DKDSSAESSAPEEGEV---SDSDSNSSSSSSDSDSSSED 175
+ TM++Q K + ++ + PE+ E + + + D
Sbjct: 463 EETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 522
Query: 176 EEFHDGYGEDLMGDEEDRARLEQMTEKE-----REQELFN---RIEKR--EVLKRRFEIK 225
+E G + + E+ R + +QM E+E +EQ++++ R+EK+ E K+ ++ +
Sbjct: 523 QEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQE 582
Query: 226 KKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRS-KRDEKLDKKSQAM-- 282
+K++ ++ ++EKK ++EEE +++ ++QE + +E + +++EK+ ++ + M
Sbjct: 583 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWE 642
Query: 283 -------EELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTS 335
+E K ++R E L + + ++ E + EE+ + + EK +
Sbjct: 643 QEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKK 702
Query: 336 SSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLE 370
+ D+E+ +EE + + + EE +R K++
Sbjct: 703 TWDQEKMREEESMREREKKMREEEEMMREQEEKMQ 737
Score = 67.4 bits (163), Expect = 4e-11
Identities = 93/433 (21%), Positives = 184/433 (42%), Gaps = 56/433 (12%)
Query: 184 EDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKL--KTAKKKEKKEKKK 241
E+ M +E R R ++ +E+E+EL + E RE ++ E ++K+ + K +E++EK
Sbjct: 313 EEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMW 372
Query: 242 KQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLA 301
+QEE +++ ++ Q +ER ++DE+L +K + M E + E+ + E
Sbjct: 373 RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKM 432
Query: 302 KKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNR 361
++Q KT + + +EEE + EK R + E+EEK + ++ +E +
Sbjct: 433 QEQEKKTRD-QEEKMQEEERIREREKKMREEE-ETMREQEEKMQKQEENMWEQEEKEWQQ 490
Query: 362 VRLSRHKLERWCHMPFFAKTVTGCFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGTR 421
RL K + W K + +I E
Sbjct: 491 QRLPEQKEKLW---------------------EQEKMQEQEEKIWEQEEKI--------- 520
Query: 422 TNKGLQLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDEINKKELSIKE 481
+ + G +++++R E + Q E + + +E M ++ +E +K+ +E
Sbjct: 521 --RDQEEMWGQEKKMWRQEKMREQ---EDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQE 575
Query: 482 ALNYKFNDQDIEEIVKEKERFR----KAPPNYAMKKTQLLKEKAMAEDLGDQ-----DKA 532
+ D EE ++E+ER R K M + Q K + E + +Q ++
Sbjct: 576 KKTW-----DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQE 630
Query: 533 KQIQDQLNELEERAEALDRQRTKNISAISYINQRNREW---NIVESEKALVAESHNMKNQ 589
+++Q+Q ++ E+ E + Q K Q+ + W + E EK E + +
Sbjct: 631 EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQE 690
Query: 590 QMDPFTRRQCKPT 602
+M+ T+ Q K T
Sbjct: 691 KMEKKTQEQEKKT 703
Score = 65.9 bits (159), Expect = 1e-10
Identities = 60/305 (19%), Positives = 136/305 (44%), Gaps = 10/305 (3%)
Query: 65 DQELLSLAKRKRSDSEEK----EPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKI 120
+QE + + K + EEK E Q E ++ + + + + +
Sbjct: 502 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 561
Query: 121 EKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHD 180
+++ M+K+ + ++ E E E + + ++E+ +
Sbjct: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE 621
Query: 181 GYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKK 240
E+ M ++E++ + ++ E+E++++ + EK +R E K+KL +K +++EK
Sbjct: 622 Q--EEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKM 679
Query: 241 KKQEE---EQEK-KKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRT 296
++QEE EQEK +K TQ QE + K R + + +KK + EE+ E+E++
Sbjct: 680 QEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQ 739
Query: 297 AELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLP 356
E + +++ + E+EE+ + ++ + ++ +E+E+I + + +
Sbjct: 740 EEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQ 799
Query: 357 EELNR 361
EE R
Sbjct: 800 EEKMR 804
Score = 62.0 bits (149), Expect = 2e-09
Identities = 67/325 (20%), Positives = 132/325 (40%), Gaps = 21/325 (6%)
Query: 43 KKRKGRVVIDSDTEDSGSDENLDQE--LLSLAKRKRSDSEEKEPPVSQPAASSDSETSDS 100
K R+ + + + + + +E + +E + K+ R + E + ++
Sbjct: 425 KMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQE 484
Query: 101 DDEWT---FGSNKNKKKGKARKIEKKGTMKKQANKTASS----GSSDKDSSAESSAPEEG 153
+ EW K K + + E++ + +Q K G K E +E
Sbjct: 485 EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544
Query: 154 EVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIE 213
++ + + E E E D+E E+M E+ER +E ++
Sbjct: 545 QMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQE-----EKMREEERMREREKKMR 599
Query: 214 KREVLKRRFEIKKKLKTAKKKEKKEKKKKQEE---EQEKKKLTQ---IQESQVTSHNKER 267
+ E + R E K + + K +E++EK +QEE EQE+K Q + E + ++R
Sbjct: 600 EEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQR 659
Query: 268 RSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDE-EEEEDDKSSE 326
++ EKL + + E+ K + ++ K E + KK + + + ++ EEE + E
Sbjct: 660 LPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRERE 719
Query: 327 KSDRSSRTSSSDEEEEKEEIPPKSQ 351
K R ++EE+ +E K Q
Sbjct: 720 KKMREEEEMMREQEEKMQEQEEKMQ 744
Score = 60.5 bits (145), Expect = 5e-09
Identities = 57/296 (19%), Positives = 134/296 (45%), Gaps = 34/296 (11%)
Query: 80 EEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSS 139
+EK + + + D ++ W G+ +K+ ++ M++Q ++
Sbjct: 503 QEKMQEQEEKIWEQEEKIRDQEEMW----------GQEKKMWRQEKMREQEDQMWEQEEK 552
Query: 140 DKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQM 199
+D +E ++ D + + + + + D+E E+ M + E + R E+
Sbjct: 553 MRD--------QEQKMWDQEERMEKKTQEQEKKTWDQE-EKMREEERMREREKKMREEEE 603
Query: 200 TEKEREQELFNRIEK-REVLKRRFEIKKKLKTAKKKEKKEKKKKQEEE----------QE 248
+E+E+++ + EK +E ++ +E ++K++ ++K ++++K E+E ++
Sbjct: 604 MMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQ 663
Query: 249 KKKLTQIQESQVTSHNKERRSK--RDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPL 306
K+KL + ++ Q +E+ K EK++KK+Q E+ ++EK R E + +++
Sbjct: 664 KEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKM--REEESMREREKK 721
Query: 307 KTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRV 362
E E+EE+ + EK EE+ E+ + LPE+ ++
Sbjct: 722 MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKL 777
Score = 55.5 bits (132), Expect = 2e-07
Identities = 47/275 (17%), Positives = 132/275 (48%), Gaps = 13/275 (4%)
Query: 102 DEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEG--EVSDSD 159
+E + K + + K++++ ++++ K + ++ + EE E + +
Sbjct: 428 EEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKE 487
Query: 160 SNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLK 219
+ E E+ + E+ + ++E++ R +Q +E++++ + + RE
Sbjct: 488 WQQQRLPEQKEKLWEQEKMQEQ--EEKIWEQEEKIR-DQEEMWGQEKKMWRQEKMREQED 544
Query: 220 RRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKS 279
+ +E ++K++ ++K ++++ +++ QE++K T QE ++ +ER +R++K+ ++
Sbjct: 545 QMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKM--REEERMREREKKMREEE 602
Query: 280 QAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEE---EEDDKSSEKSDRSSRTSS 336
+ M E + EK + + ++ +++ + E ++EE E+++K E+ ++
Sbjct: 603 EMMRE---QEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQR 659
Query: 337 SDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLER 371
E++EK K Q +E + K+E+
Sbjct: 660 LPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEK 694
Score = 55.1 bits (131), Expect = 2e-07
Identities = 55/246 (22%), Positives = 113/246 (45%), Gaps = 28/246 (11%)
Query: 154 EVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIE 213
E + + E+E + E M +EE+ R ++ +++E+ ++ + E
Sbjct: 428 EEKKMQEQEKKTRDQEEKMQEEERIRER--EKKMREEEETMREQEEKMQKQEENMWEQEE 485
Query: 214 KREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEE----------QEKKKLTQI----QESQ 259
K +R E K+KL +K +++E+K ++EE QEKK Q QE Q
Sbjct: 486 KEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQ 545
Query: 260 VTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEE- 318
+ ++ R + ++K+ + + ME+ E+EK+ E + +++ ++ E +EEE
Sbjct: 546 MWEQEEKMRDQ-EQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEM 604
Query: 319 --EEDDKSSEKSDRSSRTSSS--DEEEEKEEIPPK--SQPVSLPEELNRV----RLSRHK 368
E+++K E+ ++ ++EE+ +E K Q + E+ ++ RL K
Sbjct: 605 MREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQK 664
Query: 369 LERWCH 374
+ W H
Sbjct: 665 EKLWEH 670
Score = 54.7 bits (130), Expect = 3e-07
Identities = 91/504 (18%), Positives = 209/504 (41%), Gaps = 42/504 (8%)
Query: 104 WTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEE-GEVSDSDSNS 162
W +++GK R+ E+K M +Q + ++ E +E E +
Sbjct: 296 WRQEERLREQEGKMREQEEK--MWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQ 353
Query: 163 SSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRF 222
+ + ++E E+ + ++E + R ++ +++E+ ++ + E+ + R
Sbjct: 354 EEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERM 413
Query: 223 EIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDE------KLD 276
++K+ ++ EK ++KK + EQEKK Q ++ Q +ER K E + +
Sbjct: 414 REQEKMW--EQVEKMREEKKMQ-EQEKKTRDQEEKMQEEERIREREKKMREEEETMREQE 470
Query: 277 KKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEE--EEDDKSSEKSDRSSRT 334
+K Q EE E+E+++ + L +K+ L E + EE+ E+++K ++ + +
Sbjct: 471 EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE 530
Query: 335 SSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAKTVTGCFVRIGIGNH 394
+E+ E Q + E+ ++R K+ W K +
Sbjct: 531 KKMWRQEKMRE-----QEDQMWEQEEKMRDQEQKM--WDQEERMEKKTQEQEKKTWDQEE 583
Query: 395 NSKPVYRVAEITGVV-ETAKVYQLGGTRTNKGLQLRHGNDQRVFRLEFVSNQEFTESEFM 453
+ R+ E + E ++ + + + + +++++ E ++ E E
Sbjct: 584 KMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQE----EKMQEQEEK 639
Query: 454 KW--KEAMFSAGMQLPTLDEI--NKKELSIKEALNYKFNDQDIEEIVKEKERFRKAPPNY 509
W +E M+ ++ + K++L E + + Q+ EE + E+E+ K
Sbjct: 640 MWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQ 699
Query: 510 AMKKTQLLKEKAMAEDLGDQDKAKQIQDQLNELEERAEALDRQRTKNISAISYINQRNRE 569
KKT ++ M E+ +++ K+++++ + E+ E + Q K + +E
Sbjct: 700 E-KKT--WDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEK---------MQEQE 747
Query: 570 WNIVESEKALVAESHNMKNQQMDP 593
+ E E+ + + M QQ P
Sbjct: 748 EEMWEQEEKMWEQEEKMWEQQRLP 771
Score = 53.5 bits (127), Expect = 7e-07
Identities = 47/286 (16%), Positives = 120/286 (41%), Gaps = 26/286 (9%)
Query: 73 KRKRSDSEEK----EPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKK 128
+ K D E+K E + + + +T D ++ K +++ + R+ EKK ++
Sbjct: 550 EEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE-------KMREEERMREREKKMREEE 602
Query: 129 QANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMG 188
+ + +++ + + E + + + ++E + L
Sbjct: 603 EMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPE 662
Query: 189 DEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQE 248
+E E+M E+E+ QE +I ++E +++KK + +KK ++K ++EE
Sbjct: 663 QKEKLWEHEKMQEQEKMQEQEEKIWEQE------KMEKKTQEQEKKTWDQEKMREEESMR 716
Query: 249 KKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAM---------EELKAEREKRKNRTAEL 299
+++ +E ++ +E+ +++EK+ ++ + M +E K ++R E
Sbjct: 717 EREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEK 776
Query: 300 LAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEE 345
L + + ++ E + EE+ D + + ++ +EE
Sbjct: 777 LWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEE 822
Score = 50.8 bits (120), Expect = 4e-06
Identities = 46/296 (15%), Positives = 129/296 (43%), Gaps = 32/296 (10%)
Query: 65 DQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDE-WTFGSNKNKKKGKARKIEKK 123
++E++ + K + EEK + + + + +++ W +++ K + ++
Sbjct: 601 EEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRL 660
Query: 124 GTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYG 183
K++ + +K E E+ ++ + D + E+E +
Sbjct: 661 PEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREK 720
Query: 184 -----EDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKE 238
E++M ++E++ + ++ +E+E+E++ + EK + + +++L E+KE
Sbjct: 721 KMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLP-----EQKE 775
Query: 239 KKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAE 298
K + E+ QE++K+ + +E RD++ + Q E+++ + EK + + +
Sbjct: 776 KLWEHEKMQEQEKIWEQEEKM-----------RDQEEKMRGQE-EKMRGQEEKMRGQEEK 823
Query: 299 LLAKKQPL---------KTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEE 345
+ +++ + + +++ +E+ EE + E+ R +EE+ E
Sbjct: 824 MWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMRE 879
Score = 43.9 bits (102), Expect = 5e-04
Identities = 70/400 (17%), Positives = 173/400 (43%), Gaps = 34/400 (8%)
Query: 199 MTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQES 258
+ E E+ + N E + L+R + +++T +E+ +++++ EQEKK Q ++
Sbjct: 236 LAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 295
Query: 259 -QVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEE 317
+ +E+ K E+ +K + + L+ + ++ + + EL +K+ + E + EE
Sbjct: 296 WRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEE 355
Query: 318 E--EEDDKSSEKSDRSSRTSSSDEEEEK----EEIPPKSQPVSLPEELNRVRLSRHKLER 371
+ E+++K E+ ++ R E+EK +E + Q + E+ R+R ++
Sbjct: 356 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMRE 415
Query: 372 WCHMPFFAKTVTGCFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGTRTNKGLQLRHG 431
M + V ++ E + E K + + + ++R
Sbjct: 416 QEKM--------------------WEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER 455
Query: 432 NDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDEINKKELSIKEALNYKFNDQD 491
+ E + Q E + K +E M+ + + +++ + E K +Q+
Sbjct: 456 EKKMREEEETMREQ---EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE--QEKMQEQE 510
Query: 492 IEEIVKEKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDKAKQIQDQLNELEERAEALDR 551
E+I +++E+ R + +K +EK ++ ++ ++++DQ ++ ++ E +++
Sbjct: 511 -EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
Query: 552 QRTKNISAISYINQRNR-EWNIVESEKALVAESHNMKNQQ 590
+ + ++ R E + E EK + E M+ Q+
Sbjct: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE 609
Score = 43.5 bits (101), Expect = 7e-04
Identities = 47/162 (29%), Positives = 84/162 (51%), Gaps = 19/162 (11%)
Query: 196 LEQMTEKEREQ---ELF-NRIEKREVLKRRFEIKKKLKTAKKKEKKE-----KKKKQEEE 246
+E++T KER+ EL+ N I E+ K+ E+++KL A+ EK E K+ K++ E
Sbjct: 199 IEELT-KERDALSLELYRNTITNEELKKKNAELQEKLPLAES-EKSEIQLNVKELKRKLE 256
Query: 247 QEKKKLTQIQESQVTSHNKERRSKRDEKL---DKKSQAMEELKAEREKRKNRTAELLAKK 303
+ K L Q+Q T+ +E +++E+L +KK + EE K R++ + R E ++
Sbjct: 257 RAKFLLPQVQ----TNTLQEEMWRQEEELREQEKKIRKQEE-KMWRQEERLREQEGKMRE 311
Query: 304 QPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEE 345
Q K E+E++ + EK R + EE+ +E+
Sbjct: 312 QEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQ 353
Score = 37.4 bits (85), Expect = 0.048
Identities = 32/153 (20%), Positives = 70/153 (45%), Gaps = 18/153 (11%)
Query: 237 KEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEK------------LDKKSQAMEE 284
+E KKK E QEK L + ++S++ + KE + K + ++ + EE
Sbjct: 221 EELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE 280
Query: 285 LKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEE--EDDKSSEKSDRSSRTSSSDEEEE 342
L+ + +K + + ++ +++ L+ E ++EE+ +K + ++ R + E+
Sbjct: 281 LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQ 340
Query: 343 KE----EIPPKSQPVSLPEELNRVRLSRHKLER 371
KE E + Q + E+ ++R K+ R
Sbjct: 341 KELREQEEQMQEQEEKMWEQEEKMREQEEKMWR 373
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 68.6 bits (166), Expect = 2e-11
Identities = 52/195 (26%), Positives = 95/195 (48%), Gaps = 5/195 (2%)
Query: 155 VSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEK 214
VS S + + +S+ E E E + +R + E+ K+RE+ ++
Sbjct: 20 VSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKR 79
Query: 215 REVLKRRFEIKKKLKTAKKKEKK--EKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRD 272
+E K+R E ++K + +KKEKK E+K++ E++KKK + +E + + +R KR
Sbjct: 80 KEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRR 139
Query: 273 EKLDKKSQAMEELKAERE-KRKNRTAELLAKKQPLKTSEVYSDDEEEE--EDDKSSEKSD 329
+K +K + E+ + +RE KRK R E KK+ E + E +E E K +K
Sbjct: 140 KKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKER 199
Query: 330 RSSRTSSSDEEEEKE 344
R + D + +++
Sbjct: 200 RKKKERKKDRKTDRQ 214
Score = 67.8 bits (164), Expect = 3e-11
Identities = 40/169 (23%), Positives = 83/169 (49%)
Query: 203 EREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTS 262
+RE E +RE KR E ++K + KK++KK KK+++ +E+E+K+ + ++ +
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERR 90
Query: 263 HNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDD 322
+ R+ K+++K ++ Q + ++++RK R E +++ + +E + +
Sbjct: 91 EKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKRE 150
Query: 323 KSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLER 371
K K +R + +E E+K E K + + R R K ER
Sbjct: 151 KERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKER 199
Score = 62.8 bits (151), Expect = 1e-09
Identities = 42/203 (20%), Positives = 101/203 (49%), Gaps = 9/203 (4%)
Query: 189 DEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQE 248
+ +R + ++ EKER++E + +K+ K+R K++ + K++EK+ K+++++E ++
Sbjct: 39 ERREREKRKREREKERKRERGKKEKKKR--KKRERGKERERKRKEREKQRKERREKERRK 96
Query: 249 KKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKT 308
+KK + +E + + ++ K ++ +++++ E K ++ ++K R E +K+ K
Sbjct: 97 RKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKR 156
Query: 309 SEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHK 368
++EE + K + +R R + +E +E + + +E + R + +
Sbjct: 157 ERKRKKRKKEEREKK--RERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQ 214
Query: 369 LERWCHMP-----FFAKTVTGCF 386
+ P F TVTG F
Sbjct: 215 TDSQVFRPLRESAFNRVTVTGVF 237
Score = 58.5 bits (140), Expect = 2e-08
Identities = 41/208 (19%), Positives = 95/208 (45%), Gaps = 17/208 (8%)
Query: 108 SNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSS 167
+ + ++ K R+ +K +++ + G +K + +E E +
Sbjct: 30 TQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKER 89
Query: 168 DSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKK 227
++E E + + R R E+ +KER++ E+ +R + KK+
Sbjct: 90 ------REKERRKRKKEKKKRERKQRGRRERKKKKERKER-----ERENKQRRERKRKKR 138
Query: 228 LKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSK---RDEKLDKKSQAMEE 284
K ++KE+K +K++ + E+++KK + + + N++ R K R E+ ++K + +E
Sbjct: 139 RKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKE 198
Query: 285 LKAEREKRKNRTAELLAKKQ---PLKTS 309
+ ++E++K+R + Q PL+ S
Sbjct: 199 RRKKKERKKDRKTDRQTDSQVFRPLRES 226
Score = 37.4 bits (85), Expect = 0.048
Identities = 32/143 (22%), Positives = 57/143 (39%), Gaps = 36/143 (25%)
Query: 229 KTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAE 288
K ++E + KK+++E E+ K++ KER+ +R +K KK + E K
Sbjct: 27 KPCTQRESERKKERREREKRKRE-----------REKERKRERGKKEKKKRKKRERGKER 75
Query: 289 REKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPP 348
KRK R + ++ E+E + EK R + E ++K+E
Sbjct: 76 ERKRKEREKQRKERR-------------EKERRKRKKEKKKRERKQRGRRERKKKKE--- 119
Query: 349 KSQPVSLPEELNRVRLSRHKLER 371
R R ++ + ER
Sbjct: 120 ---------RKERERENKQRRER 133
Score = 34.7 bits (78), Expect = 0.31
Identities = 27/122 (22%), Positives = 52/122 (42%), Gaps = 5/122 (4%)
Query: 250 KKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTS 309
K TQ + + + + KR+ + ++K E K E++KRK R +++ +
Sbjct: 27 KPCTQRESERKKERREREKRKREREKERK---RERGKKEKKKRKKRERGKERERKRKERE 83
Query: 310 EVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKL 369
+ + E+E + EK R + E ++K+E K + + R R R K
Sbjct: 84 KQRKERREKERRKRKKEKKKRERKQRGRRERKKKKE--RKERERENKQRRERKRKKRRKK 141
Query: 370 ER 371
+R
Sbjct: 142 KR 143
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 67.8 bits (164), Expect = 3e-11
Identities = 59/312 (18%), Positives = 145/312 (46%), Gaps = 12/312 (3%)
Query: 54 DTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETS-DSDDEWTFGSNKNK 112
D +DS + LD+ L ++KR +E++ + + S D ++ DS +E ++ +
Sbjct: 3 DEKDSWKVKTLDE---ILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRME 59
Query: 113 KKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAP---EEGEVSDSDSNSSSSSSDS 169
+ ++ +M+ + + S + ++ + + + S S+
Sbjct: 60 ITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGG 119
Query: 170 DSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKR---EVLKRRFEIKK 226
+ E+ + +E+D+AR E +K RE + +R E L+R+ E ++
Sbjct: 120 KHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERER 179
Query: 227 KLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELK 286
K++ +K+++++K++++ E+ +K+ +E V++H++ R +K+ + +
Sbjct: 180 KMREQQKEQREQKERERRAEERRKEREARRE--VSAHHRTMREDYSDKVKASHWSRSPPR 237
Query: 287 AEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEI 346
RE+ + K++ ++ ++ SD ++ + ++ + ++ SS S S EEE+EE
Sbjct: 238 PPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE 297
Query: 347 PPKSQPVSLPEE 358
+ + S EE
Sbjct: 298 EEEEEEGSTSEE 309
Score = 52.8 bits (125), Expect = 1e-06
Identities = 66/341 (19%), Positives = 137/341 (40%), Gaps = 26/341 (7%)
Query: 43 KKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKR----SDSEEKEPPVSQPAASSDSETS 98
+KRK + S + + G + ++ +RKR D +E + + +
Sbjct: 103 EKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSR 162
Query: 99 DSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSD- 157
D K +++ K R+ +K+ +K+ + A ++++ E SA D
Sbjct: 163 RERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDY 222
Query: 158 SDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREV 217
SD +S S S E F +GD + E+M E++ +L + +
Sbjct: 223 SDKVKASHWSRSPPRPPRERFE-------LGDGRKPVKEEKMEERDLLSDLQDISDSERK 275
Query: 218 LKRRFEIKKKLKTAKKKEKKEKKKKQE-----EEQEKKKLTQIQESQVTSHNKERRSKRD 272
+ + ++E++E+++++E EE E+++ + +E + T N E S++
Sbjct: 276 TSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQS 335
Query: 273 EKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSS 332
+ + EE +E E+R+N L+ + E EE +++ E + +SS
Sbjct: 336 AE-----EVSEEEMSEDEERENENHLLVVPESRFDR----DSGESEEAEEEVGEGTPQSS 386
Query: 333 RTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWC 373
+ D + + P LP+ L ++ R E C
Sbjct: 387 ALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQC 427
Score = 40.0 bits (92), Expect = 0.007
Identities = 40/180 (22%), Positives = 71/180 (39%), Gaps = 38/180 (21%)
Query: 187 MGDEEDRARL----EQMTEKEREQELFNR------------------IEKREVLKRRFEI 224
MGDE+D ++ E + EK+R +E + +E+ E+ R EI
Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 60
Query: 225 KKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEE 284
+ ++++ E + ++++ K Q+ + H K+ KR EK +S + E
Sbjct: 61 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKD--EKRKEKRRHRSHSAEG 118
Query: 285 LKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKE 344
K R K K R E + EE DK+ + +R R + E +E
Sbjct: 119 GKHARVKEKEREHERRKR--------------HREEQDKARREWERQKRREMAREHSRRE 164
>gi|125656165 THO complex 2 [Homo sapiens]
Length = 1593
Score = 67.4 bits (163), Expect = 4e-11
Identities = 74/338 (21%), Positives = 139/338 (41%), Gaps = 64/338 (18%)
Query: 85 PVSQPAASSDSETSDSDDEWTFGSNKNKKKGKA--RKIEKKGTMKKQANKTASSGSSDKD 142
P P++SS S SD+ T ++K++++ + + + K + + N + + S+ +
Sbjct: 1204 PGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSN 1263
Query: 143 SSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEK 202
+ + + E+G+ + + + ++ ++ L D +++ + E+ +
Sbjct: 1264 KAVKENDKEKGKEKEKEKKEKTPATTPEARV------------LGKDGKEKPKEERPNKD 1311
Query: 203 EREQELFNRIEKREVLKRRFEIKKKLKTAKKKE---KKEKKKKQEEEQEKKKLTQIQESQ 259
E+ +E R K + K +F+ ++K K K K E K QE E+EK + S+
Sbjct: 1312 EKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREK------EPSR 1365
Query: 260 VTSHNKERRSKRDEKLDKKSQAMEELKA----------EREKRKNRT------------- 296
KE +SK + K +K+ LK+ ERE+++ +
Sbjct: 1366 ERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVK 1425
Query: 297 ------AELLAKKQPLKTSEVYSDDEEEEEDDKSSEKS-DRSSRTSSSDEEEEKE----- 344
E AK T S +E E D K +KS +RS DE++ KE
Sbjct: 1426 DSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDH 1485
Query: 345 -----EIPPKSQPVSLPEELNRVRLSRHKLERWCHMPF 377
E+PP EE + +S+HK E C P+
Sbjct: 1486 SNNDREVPPDLTK-RRKEENGTMGVSKHKSESPCESPY 1522
Score = 60.5 bits (145), Expect = 5e-09
Identities = 73/365 (20%), Positives = 126/365 (34%), Gaps = 46/365 (12%)
Query: 9 RAAAAAAAVAVPLAGGQEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQEL 68
R+ AV + +G+ G GS VK+ + + E E
Sbjct: 1233 RSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEA 1292
Query: 69 LSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKK 128
L K + +E+ P + A + T SD E K KK+ KA+ + K T+
Sbjct: 1293 RVLGKDGKEKPKEERPNKDEKARETKERTPKSDKE----KEKFKKEEKAKDEKFKTTVPN 1348
Query: 129 QANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMG 188
+K+ +K+ S E +E E G + G
Sbjct: 1349 AESKSTQEREREKEPSRERDIAKE-------------------MKSKENVKGGEKTPVSG 1389
Query: 189 DEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKK--------EKK 240
+ + E EREQ+ +I+ +K L K+ K
Sbjct: 1390 SLKSPVPRSDIPEPEREQKR-RKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLS 1448
Query: 241 KKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELK--AEREKRKNRTAE 298
K +E E +KK L + +E K+ + +++ K D + E +R K +N T
Sbjct: 1449 KSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMG 1508
Query: 299 LLAKKQPLKTSEVYSDDEEEEE------------DDKSSEKSDRSSRTSSSDEEEEKEEI 346
+ K Y +++++E+ D SEK D+ S + +KE+I
Sbjct: 1509 VSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKI 1568
Query: 347 PPKSQ 351
K +
Sbjct: 1569 EKKEK 1573
Score = 31.2 bits (69), Expect = 3.5
Identities = 20/53 (37%), Positives = 27/53 (50%), Gaps = 2/53 (3%)
Query: 324 SSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMP 376
SSEK D R ++EEEK E PP +Q + L E L ++ +H MP
Sbjct: 319 SSEKMDE--REKEKEKEEEKVEKPPDNQKLGLLEALLKIGDWQHAQNIMDQMP 369
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 67.0 bits (162), Expect = 6e-11
Identities = 69/337 (20%), Positives = 139/337 (41%), Gaps = 37/337 (10%)
Query: 43 KKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDD 102
KK K R I+ + + + ++E +R+R E+E + D D
Sbjct: 297 KKEKERQEIEKERRERERERERERE-----RREREREREREREREKEKERERERERDRDR 351
Query: 103 EWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNS 162
+ T ++++ + + R +++ + + +++ S S +D E E E
Sbjct: 352 DRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKS-RDRERERERERERERERERERE 410
Query: 163 SSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELF--NRIEKREVLKR 220
+ + E E D D DEED ++ K RE+E R++ E+ +R
Sbjct: 411 REREREREREREREREKDKK-RDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRER 469
Query: 221 RFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKE---RRSKRDEKLDK 277
KK + +K+ ++E+++++E +E K+L + E + R S ++L
Sbjct: 470 -----KKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRD 524
Query: 278 KSQAMEELKAEREKRKNRTAE----LLAKKQPLKTSEVY----------------SDDEE 317
+ + ME + +R++ K E LLA+ P +E+ + E
Sbjct: 525 REKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESE 584
Query: 318 EEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVS 354
EEE++K ++ R +E E+K + P +P+S
Sbjct: 585 EEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPIS 621
Score = 64.7 bits (156), Expect = 3e-10
Identities = 57/267 (21%), Positives = 117/267 (43%), Gaps = 15/267 (5%)
Query: 110 KNKKKGKARKIEKKGTMK---KQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSS 166
K KK+ + ++IEK+ + ++ + +++ E +E E +
Sbjct: 295 KGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRT 354
Query: 167 SDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMT---EKEREQELFNRIEKREVLKRRFE 223
+ D + E D E +DR+R + + E+ERE+E E+ +R E
Sbjct: 355 KERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERE 414
Query: 224 IKKKLKTAKKKEKKEKKKKQEEEQ---EKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQ 280
+++ + +++EK +K+ ++E+E+ E++KL + + ++ + R K E ++K
Sbjct: 415 REREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAY--QERLKNWEIRERKKT 472
Query: 281 AMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEE 340
E +AERE+ + R K+ + E D +++ +D K S R ++E
Sbjct: 473 REYEKEAEREEERRRE----MAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKE 528
Query: 341 EEKEEIPPKSQPVSLPEELNRVRLSRH 367
E +E K + L E R+ H
Sbjct: 529 MEADERDRKREKEELEEIRQRLLAEGH 555
Score = 63.9 bits (154), Expect = 5e-10
Identities = 63/278 (22%), Positives = 120/278 (43%), Gaps = 35/278 (12%)
Query: 121 EKKGTMKKQANKTAS--SGSSDKDSSAESSAPEEGEVSDSDS-NSSSSSSDSDSSSEDEE 177
EKK +K A A + K +S ++ PE D ++ + + D E
Sbjct: 154 EKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEV 213
Query: 178 FHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRI-----------------------EK 214
Y +L ++ + +KE+++++F R +K
Sbjct: 214 LIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDK 273
Query: 215 REVLKRRFEIKKKLKTAKK-KEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDE 273
R+++ R EI K T KK +E+K KK+K+ +E EK++ + +E + +ER +R+
Sbjct: 274 RDLISR--EISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERER 331
Query: 274 KLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSR 333
+ +++ + E + ER++ ++RT E + + E D + E D++ ++S SR
Sbjct: 332 EREREKEKERERERERDRDRDRTKE----RDRDRDRERDRDRDRERSSDRNKDRS--RSR 385
Query: 334 TSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLER 371
S D E E+E + + E R R + ER
Sbjct: 386 EKSRDRERERERERERERERERERERERERERERERER 423
Score = 62.4 bits (150), Expect = 1e-09
Identities = 48/226 (21%), Positives = 105/226 (46%), Gaps = 10/226 (4%)
Query: 152 EGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNR 211
E + D S S D+ E+E+ ++ E ++ R E+ E+ERE+E R
Sbjct: 270 EEDKRDLISREISKFRDTHKKLEEEKGK----KEKERQEIEKERRERERERERERERRER 325
Query: 212 IEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKR 271
+RE + R + K++ + ++ +++ K+++ ++++++ + + NK+R R
Sbjct: 326 EREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSR 385
Query: 272 DEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDD----EEEEEDDKSSEK 327
++ D++ + E + ERE+ + R E +++ + E D EE+EED K
Sbjct: 386 EKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRK 445
Query: 328 SDRSSRTSSSDEEEEKE--EIPPKSQPVSLPEELNRVRLSRHKLER 371
+R R + +E + EI + + +E R R ++ +
Sbjct: 446 LERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAK 491
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 67.0 bits (162), Expect = 6e-11
Identities = 75/323 (23%), Positives = 132/323 (40%), Gaps = 36/323 (11%)
Query: 42 VKKRKGRVVIDSDTEDSGSDENLDQ---ELLSLAKRKRSDSEEKEPPV--SQPAASSDSE 96
V+K+K + I T+D+ EN D E +S K ++ + + +QPA + ++
Sbjct: 520 VQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAF 579
Query: 97 TSDSDDEWTFGSNKN-KKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEV 155
SD+E K + K IE++ + N G +K ++ EV
Sbjct: 580 ---SDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEV 636
Query: 156 SDSDSNSSSSSSDSDSSSEDEEFHDGYG-------EDLMGDEEDRARLEQMTEKEREQEL 208
S+ + S + D D +G E+ E+D+ R E E E+EL
Sbjct: 637 SEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKEL 696
Query: 209 FNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERR 268
EK E KR E E+++K+++Q ++E+ + + + +E
Sbjct: 697 ---AEKEEWKKRDGE-----------EQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEE 742
Query: 269 SKRDEKLDKKSQAM-----EELKAEREKRK-NRTAELLAKKQPLKTSEVYSDDEEEEEDD 322
R+E+ +K+ + EE++ EREK + R E A K+ E + EEEE +
Sbjct: 743 GDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETE 802
Query: 323 KSSEKSDRSSRTSSSDEEEEKEE 345
E+ + + EE K E
Sbjct: 803 GRGEEKEEGGEVEGGEVEEGKGE 825
Score = 55.1 bits (131), Expect = 2e-07
Identities = 63/292 (21%), Positives = 130/292 (44%), Gaps = 26/292 (8%)
Query: 60 SDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKAR- 118
SD+ D+ +S K K S E ++ P + + + E S + W + +K K R
Sbjct: 627 SDDLTDKAEVSEGKAK-SVGEAEDGPEGRGDGTCE-EGSSGAEHWQDEEREKGEKDKGRG 684
Query: 119 KIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEF 178
++E+ G +K+ ++K+ + E+ + + + + + E+E
Sbjct: 685 EMERPGEGEKEL--------AEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEH- 735
Query: 179 HDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKE 238
G GE+ GD E+ E ++E E E ++E +R+ E ++ K K +E+ +
Sbjct: 736 --GEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKE-ERAGKEEKGEEEGD 792
Query: 239 KKKKQEEE-----QEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRK 293
+ + +EEE +EK++ +++ +V +E + +R+E+ ++ EE + E E+ +
Sbjct: 793 QGEGEEEETEGRGEEKEEGGEVEGGEV----EEGKGEREEEEEEGEGEEEEGEGEEEEGE 848
Query: 294 NRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEE 345
E K + + E +EE EE + E+ + E E +EE
Sbjct: 849 GEEEEGEGKGE--EEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEE 898
Score = 55.1 bits (131), Expect = 2e-07
Identities = 64/362 (17%), Positives = 142/362 (39%), Gaps = 40/362 (11%)
Query: 23 GGQEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEK 82
G +EG G G +K +G V + E+ + ++E + EE+
Sbjct: 787 GEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEE--------EGEGEEE 838
Query: 83 EPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKK-QANKTASSGSSDK 141
E + E + + E G K +++G+ + E++G + + + G ++
Sbjct: 839 E---------GEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEE 889
Query: 142 DSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTE 201
+ E EEGE + + +EE +G GE G+EE+ + E
Sbjct: 890 EGEGEGEE-EEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGE---GEEEEGEGEGEDGE 945
Query: 202 KEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVT 261
E E+E + +E +++ + +E+ E + ++ E + +E +
Sbjct: 946 GEGEEE-----------EGEWEGEEEEGEGEGEEEGEGEGEEGEGEG-------EEEEGE 987
Query: 262 SHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEED 321
+E + + + + + + E + E E+ E+ ++ + E ++E EE +
Sbjct: 988 GEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEERE 1047
Query: 322 DKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAKT 381
+ + +R +R +EE + +E + EE +V + ++ H + K+
Sbjct: 1048 KEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKS 1107
Query: 382 VT 383
VT
Sbjct: 1108 VT 1109
Score = 53.9 bits (128), Expect = 5e-07
Identities = 67/344 (19%), Positives = 133/344 (38%), Gaps = 27/344 (7%)
Query: 8 GRAAAAAAAVAVPLAGG----QEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDEN 63
G+A + A P G +EGS G +K KGR + E G E
Sbjct: 639 GKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGR----GEMERPGEGE- 693
Query: 64 LDQELLSLAKRKRSDSEEKEPPVSQPAASSD-SETSDSDDEWTFGSNKNKKKGKARKIEK 122
+EL + K+ D EE+E + + ++ + E G + ++ + + EK
Sbjct: 694 --KELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEK 751
Query: 123 KGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGY 182
+G K++ G +K+ G+ + D +EE +G
Sbjct: 752 EGEGKEEGEGEEVEGEREKEEGERKKEERAGK-------EEKGEEEGDQGEGEEEETEGR 804
Query: 183 GEDLM-GDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKK 241
GE+ G E + +E+ + E+E E+ E E + + + + K ++E ++
Sbjct: 805 GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEE 864
Query: 242 KQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLA 301
+ EE+ ++ + +E + +E E+ + + + EE + E E+ +
Sbjct: 865 GEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEE-------G 917
Query: 302 KKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEE 345
+ + + E + EEEE + E + + E E+EE
Sbjct: 918 EGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEE 961
Score = 36.6 bits (83), Expect = 0.083
Identities = 42/263 (15%), Positives = 96/263 (36%), Gaps = 33/263 (12%)
Query: 23 GGQEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEK 82
G +E G G G ++ +G+ + + G E ++E + + EE+
Sbjct: 895 GEEEEGEGEGEEEGEGEGEEEEGEGK---GEEEGEEGEGEGEEEEGEGEGEDGEGEGEEE 951
Query: 83 EPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKD 142
E + + + ++E + + +G+ + E +G ++ + G +++
Sbjct: 952 E---GEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEE 1008
Query: 143 SSAESSAPEEGEVS-------------DSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGD 189
E EEGEV + + + + E+ + +
Sbjct: 1009 GEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENR------RNREEE 1062
Query: 190 EEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKK--EKKEKKKKQEEEQ 247
EE+ + ++ E+E E+ + E K+ +IK +K K K +KK Q +
Sbjct: 1063 EEEEGKYQETGEEENER------QDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGK 1116
Query: 248 EKKKLTQIQESQVTSHNKERRSK 270
E++ +Q ++ + K
Sbjct: 1117 EQRSKMPVQSKRLLKNGPSGSKK 1139
>gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo
sapiens]
Length = 1031
Score = 67.0 bits (162), Expect = 6e-11
Identities = 72/336 (21%), Positives = 134/336 (39%), Gaps = 29/336 (8%)
Query: 74 RKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKT 133
RKRS S + S+ + SD + DD + ++++++ ++R +K+ + + +
Sbjct: 9 RKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRSRDRKRL 68
Query: 134 ASSGSSDKDSSAESSAPEEGEVSDSDSNS---SSSSSDSDSSSEDEEFHDGYGEDLMGDE 190
S S ++D S E + S S S S SS + S+ E E G E
Sbjct: 69 RRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRSKEKTDGGE 128
Query: 191 EDRARLEQMTEKEREQEL----FNRIEKREVLKRRFEIKKKLKTAKKKEKKEK----KKK 242
+ + + +KE E+E F++ + E +++R E +K + ++K+ E KK+
Sbjct: 129 SSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEMRKRKERVEKWREEQRKKAMENIGELKKE 188
Query: 243 QEEEQEKKKLT----QIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAE---------- 288
EE ++ KK + E KE E+LD MEE+K E
Sbjct: 189 IEEMKQGKKWSLEDDDDDEDDPAEAEKEGNEMEGEELDPLDAYMEEVKEEVKKFNMRSVK 248
Query: 289 ----REKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKE 344
EK+ T + K + V SD ++ E + + + SS D +
Sbjct: 249 GGGGNEKKSGPTVTKVVTVVTTKKAVVDSDKKKGELMENDQDAMEYSSEEEEVDLQTALT 308
Query: 345 EIPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAK 380
K + + P + ++ + + +P AK
Sbjct: 309 GYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVPELAK 344
Score = 44.3 bits (103), Expect = 4e-04
Identities = 35/171 (20%), Positives = 83/171 (48%), Gaps = 15/171 (8%)
Query: 213 EKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSK-R 271
E R KR + ++ + +K+ K+ +++ + + + + + +RRS+ R
Sbjct: 4 ESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRSR 63
Query: 272 DEKLDKKSQAMEELKAEREKRKNRT-----AELLAKKQPLKTSEVYSDDEEEEEDDKSSE 326
D K ++S++ E ++ RE+R++R+ + ++ + ++S + ++ E +S E
Sbjct: 64 DRKRLRRSRSRERDRS-RERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRSKE 122
Query: 327 KSD-----RSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLERW 372
K+D + + D+E+EKE+ L EE+ R + ++E+W
Sbjct: 123 KTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEM---RKRKERVEKW 170
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 66.6 bits (161), Expect = 7e-11
Identities = 36/117 (30%), Positives = 62/117 (52%), Gaps = 3/117 (2%)
Query: 235 EKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKN 294
+KK+KKKK+ EE E+ + T+ +E + ++R+ KR EK KK E + E+E+ +
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEK 60
Query: 295 RTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQ 351
+ K++ K E ++EEEEE++K E+ + R + KEE K +
Sbjct: 61 KRKR---KRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKK 114
Score = 63.9 bits (154), Expect = 5e-10
Identities = 31/112 (27%), Positives = 64/112 (57%)
Query: 234 KEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRK 293
K+KK+KKK+ EE +E ++ + +E + K + +++++ KK++ E+ K + E+ K
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEK 60
Query: 294 NRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEE 345
R + KK+ + E ++EEE+E+++ E R + +EEE+E+
Sbjct: 61 KRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEK 112
Score = 59.7 bits (143), Expect = 9e-09
Identities = 33/107 (30%), Positives = 62/107 (57%), Gaps = 6/107 (5%)
Query: 189 DEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQE 248
+E++ R E+ EK +E+E K++ K + K+K + KK+++K KKKK+EEE+E
Sbjct: 23 EEKEGKRKEKRKEKRKEKE------KKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEERE 76
Query: 249 KKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNR 295
+++ + +E + + RR K+ +K +K + E+ K R K K +
Sbjct: 77 EEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRKTKKK 123
Score = 57.4 bits (137), Expect = 5e-08
Identities = 37/141 (26%), Positives = 70/141 (49%), Gaps = 19/141 (13%)
Query: 190 EEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEK 249
++ + + ++ E E +E EK K + + K+K K KKK K+ +K+K++EE+EK
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEK 60
Query: 250 KKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTS 309
K+ K ++ K +E+ +++ + EE K E EK + R + K++
Sbjct: 61 KR-----------KRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRR----- 104
Query: 310 EVYSDDEEEEEDDKSSEKSDR 330
+EEEE+ K K+ +
Sbjct: 105 ---RKEEEEEKKKKRRRKTKK 122
Score = 52.8 bits (125), Expect = 1e-06
Identities = 30/119 (25%), Positives = 68/119 (57%), Gaps = 5/119 (4%)
Query: 168 DSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKK 227
+++ + E EE + ++ E+ + + ++ +K++ +E R EK E K+R +KK
Sbjct: 9 ETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKK 68
Query: 228 LKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELK 286
K +++E++E+++++E+E+E+K +E + K+RR K +E+ KK + + K
Sbjct: 69 KKEEEEREEEEEEEEEEKEEEEK-----EEGRRRKKKKKRRRKEEEEEKKKKRRRKTKK 122
Score = 50.1 bits (118), Expect = 7e-06
Identities = 33/132 (25%), Positives = 61/132 (46%), Gaps = 10/132 (7%)
Query: 121 EKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHD 180
+KK KK+ +T + ++++ E E+ + + + +++ E EE
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEK 60
Query: 181 GYGEDLMGDEEDRARLEQMTEKER-EQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEK 239
+ R R ++ E+ER E+E EK E K +KK K ++KE++E+
Sbjct: 61 ---------KRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEE 111
Query: 240 KKKQEEEQEKKK 251
KKK+ + KKK
Sbjct: 112 KKKKRRRKTKKK 123
Score = 43.5 bits (101), Expect = 7e-04
Identities = 43/178 (24%), Positives = 71/178 (39%), Gaps = 58/178 (32%)
Query: 73 KRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANK 132
K+K+ ++EE E ++E ++ ++E G K K+K K ++ EKK K+ +
Sbjct: 4 KKKKKETEETE----------ETEETEEEEEKE-GKRKEKRKEKRKEKEKKKKTKETEKR 52
Query: 133 TASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEED 192
K EE E+
Sbjct: 53 KEKEEEEKKRKRKRKKKKEE--------------------------------------EE 74
Query: 193 RARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKK 250
R E+ E+E+E+E EK E +R KKK K +K+E++EKKKK+ + +KK
Sbjct: 75 REEEEEEEEEEKEEE-----EKEEGRRR----KKKKKRRRKEEEEEKKKKRRRKTKKK 123
Score = 36.2 bits (82), Expect = 0.11
Identities = 26/101 (25%), Positives = 42/101 (41%), Gaps = 5/101 (4%)
Query: 33 RRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAAS 92
+ G R +KRK + E E ++E KRK+ EE+ +
Sbjct: 25 KEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEE---- 80
Query: 93 SDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKT 133
+ E ++E G + KKK + RK E++ KK+ KT
Sbjct: 81 -EEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRKT 120
Score = 30.8 bits (68), Expect = 4.5
Identities = 23/111 (20%), Positives = 42/111 (37%), Gaps = 20/111 (18%)
Query: 43 KKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDD 102
KK+K +TE++ +E + + K KR + E+K+
Sbjct: 4 KKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKK------------------ 45
Query: 103 EWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEG 153
T + K K+K + K K+ KK+ + +++ E EEG
Sbjct: 46 --TKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEG 94
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.123 0.326
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,943,940
Number of Sequences: 37866
Number of extensions: 1390717
Number of successful extensions: 53422
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1025
Number of HSP's successfully gapped in prelim test: 1733
Number of HSP's that attempted gapping in prelim test: 12786
Number of HSP's gapped (non-prelim): 17093
length of query: 710
length of database: 18,247,518
effective HSP length: 109
effective length of query: 601
effective length of database: 14,120,124
effective search space: 8486194524
effective search space used: 8486194524
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.