BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] (455 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 919 0.0 gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 673 0.0 gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 228 1e-59 gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 225 7e-59 gi|155723000 mixed lineage kinase 4 [Homo sapiens] 223 2e-58 gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 218 7e-57 gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 213 3e-55 gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 209 5e-54 gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 171 2e-42 gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 171 2e-42 gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 166 3e-41 gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 166 3e-41 gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 154 2e-37 gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 154 2e-37 gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 151 1e-36 gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 151 1e-36 gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 151 1e-36 gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 151 1e-36 gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 151 1e-36 gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 143 4e-34 gi|4503787 fyn-related kinase [Homo sapiens] 143 4e-34 gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 141 1e-33 gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 141 1e-33 gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sap... 140 2e-33 gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sap... 140 2e-33 gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 135 6e-32 gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 135 6e-32 gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 134 2e-31 gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 132 5e-31 gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 132 5e-31 >gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] Length = 455 Score = 919 bits (2375), Expect = 0.0 Identities = 455/455 (100%), Positives = 455/455 (100%) Query: 1 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL 60 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL Sbjct: 1 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL 60 Query: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY Sbjct: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120 Query: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS 180 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS Sbjct: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS 180 Query: 181 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH 240 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH Sbjct: 181 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH 240 Query: 241 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD 300 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD Sbjct: 241 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD 300 Query: 301 LSFKEQELKERERRLKMWEQKLTEQSNTPLLLPLAARMSEESYFESKTEESNSAEMSCQI 360 LSFKEQELKERERRLKMWEQKLTEQSNTPLLLPLAARMSEESYFESKTEESNSAEMSCQI Sbjct: 301 LSFKEQELKERERRLKMWEQKLTEQSNTPLLLPLAARMSEESYFESKTEESNSAEMSCQI 360 Query: 361 TATSNGEGHGMNPSLQAMMLMGFGDIFSMNKAGAVMHSGMQINMQAKQNSSKTTSKRRGK 420 TATSNGEGHGMNPSLQAMMLMGFGDIFSMNKAGAVMHSGMQINMQAKQNSSKTTSKRRGK Sbjct: 361 TATSNGEGHGMNPSLQAMMLMGFGDIFSMNKAGAVMHSGMQINMQAKQNSSKTTSKRRGK 420 Query: 421 KVNMALGFSDFDLSEGDDDDDDDGEEEDNDMDNSE 455 KVNMALGFSDFDLSEGDDDDDDDGEEEDNDMDNSE Sbjct: 421 KVNMALGFSDFDLSEGDDDDDDDGEEEDNDMDNSE 455 >gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] Length = 800 Score = 673 bits (1737), Expect = 0.0 Identities = 331/331 (100%), Positives = 331/331 (100%) Query: 1 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL 60 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL Sbjct: 1 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL 60 Query: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY Sbjct: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120 Query: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS 180 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS Sbjct: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS 180 Query: 181 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH 240 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH Sbjct: 181 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH 240 Query: 241 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD 300 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD Sbjct: 241 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD 300 Query: 301 LSFKEQELKERERRLKMWEQKLTEQSNTPLL 331 LSFKEQELKERERRLKMWEQKLTEQSNTPLL Sbjct: 301 LSFKEQELKERERRLKMWEQKLTEQSNTPLL 331 >gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo sapiens] Length = 1118 Score = 228 bits (580), Expect = 1e-59 Identities = 135/344 (39%), Positives = 195/344 (56%), Gaps = 32/344 (9%) Query: 9 VQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKK------------LLKIEKEAEI 56 ++I F +L E G G FG VYRA WI EVAVK + + +EA++ Sbjct: 137 LEIDFAELTLEEIIGIGGFGKVYRAFWIGD--EVAVKAARHDPDEDISQTIENVRQEAKL 194 Query: 57 LSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAK 116 ++L H NII GV L+ PN +V E+A G L ++ R + D ++ WA +A+ Sbjct: 195 FAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR---IPPDILVNWAVQIAR 251 Query: 117 GMHYLHMEAPVKVIHRDLKSRNVVIA--------ADGVLKICDFGASRFHNHTTHMSLVG 168 GM+YLH EA V +IHRDLKS N++I ++ +LKI DFG +R + TT MS G Sbjct: 252 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAG 311 Query: 169 TFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIP 228 T+ WMAPEVI++ S+ D +SYGV+LWE+LT EVPF+G++GL VA+ V L IP Sbjct: 312 TYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIP 371 Query: 229 SSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIE 288 S+CP FA+L+ CW D RPSF I+ L ++ +SF + W+ EI+ Sbjct: 372 STCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQ 431 Query: 289 ATLERLKKLERDLSFKEQEL-------KERERRLKMWEQKLTEQ 325 ++L+ E++L E+EL K +E L+ EQ+L E+ Sbjct: 432 EMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAER 475 >gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo sapiens] Length = 954 Score = 225 bits (573), Expect = 7e-59 Identities = 134/343 (39%), Positives = 191/343 (55%), Gaps = 32/343 (9%) Query: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLL------------KIEKEAEIL 57 +I F +LQ E G G FG VYRA W + +EVAVK ++ +EA + Sbjct: 92 EIPFHELQLEEIIGVGGFGKVYRALW--RGEEVAVKAARLDPEKDPAVTAEQVCQEARLF 149 Query: 58 SVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKG 117 L H NII G L PP+ +V EYA G+L + R + ++ WA VA+G Sbjct: 150 GALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRR---VPPHVLVNWAVQVARG 206 Query: 118 MHYLHMEAPVKVIHRDLKSRNVVIA--------ADGVLKICDFGASRFHNHTTHMSLVGT 169 M+YLH +APV +IHRDLKS N++I AD VLKI DFG +R + TT MS GT Sbjct: 207 MNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGT 266 Query: 170 FPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPS 229 + WMAPEVI+ S++ D +S+GV+LWE+LT EVP++ ++ L VA+ V L IPS Sbjct: 267 YAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPS 326 Query: 230 SCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEA 289 +CP FA LL +CW+ D RP F I+ LE + SF + +W+ EI+ Sbjct: 327 TCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQH 386 Query: 290 TLERLKKLERDLSFKEQEL-------KERERRLKMWEQKLTEQ 325 + L+ E++L +E+EL + +E +L+ EQ+L E+ Sbjct: 387 MFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAER 429 >gi|155723000 mixed lineage kinase 4 [Homo sapiens] Length = 1036 Score = 223 bits (569), Expect = 2e-58 Identities = 133/359 (37%), Positives = 198/359 (55%), Gaps = 41/359 (11%) Query: 6 ASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK------------IEKE 53 +S V + F+ L+ E G G FG VYRA W Q +EVAVK + + +E Sbjct: 114 SSPVHVAFERLELKELIGAGGFGQVYRATW--QGQEVAVKAARQDPEQDAAAAAESVRRE 171 Query: 54 AEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINS------------NRSEE 101 A + ++L H NII+ GV L+ P+ +V E+A G+L + + R+ Sbjct: 172 ARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARR 231 Query: 102 MDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIA--------ADGVLKICDFG 153 + ++ WA +A+GM YLH EA V ++HRDLKS N+++ + LKI DFG Sbjct: 232 IPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFG 291 Query: 154 ASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQ 213 +R + TT MS GT+ WMAPEVI+S S+ D +SYGV+LWE+LT EVP++G++GL Sbjct: 292 LAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLA 351 Query: 214 VAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKC 273 VA+ V L IPS+CP FA+L+ +CW+ D RPSF I+ L ++ Sbjct: 352 VAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQ 411 Query: 274 NSFLHNKAEWRCEIEATLERLKKLERDLSFKEQEL-------KERERRLKMWEQKLTEQ 325 SF + +W+ EI+ + L+ E++L +E+EL K +E LK EQ+L E+ Sbjct: 412 ESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAER 470 >gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo sapiens] Length = 847 Score = 218 bits (556), Expect = 7e-57 Identities = 131/352 (37%), Positives = 192/352 (54%), Gaps = 37/352 (10%) Query: 13 FDDLQFFENCGGGSFGSVYRAKWISQ-----------DKEVAVKKLLKIEKEAEILSVLS 61 F +L+ E G G FG VYR W + D++++V + +EA + ++L+ Sbjct: 114 FQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAE-SVRQEARLFAMLA 172 Query: 62 HRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYL 121 H NII V LE PN +V EYA+ G L + R + ++ WA +A+GMHYL Sbjct: 173 HPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRR---VPPHVLVNWAVQIARGMHYL 229 Query: 122 HMEAPVKVIHRDLKSRNVV----IAADGV----LKICDFGASRFHNHTTHMSLVGTFPWM 173 H EA V VIHRDLKS N++ I +D + LKI DFG +R + TT MS GT+ WM Sbjct: 230 HCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWM 289 Query: 174 APEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPR 233 APEVI++ S+ D +S+GV+LWE+LT EVP++G++ L VA+ V L IPS+CP Sbjct: 290 APEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPE 349 Query: 234 SFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLER 293 FA+L+ CW D +RP F I+ LE++ +SF + W+ EI+ + Sbjct: 350 PFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDE 409 Query: 294 LKKLERDLSFKEQE--------------LKERERRLKMWEQKLTEQSNTPLL 331 L+ E++L +E+E L+ RE L WE ++ E+ T LL Sbjct: 410 LRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLL 461 >gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo sapiens] Length = 859 Score = 213 bits (542), Expect = 3e-55 Identities = 122/307 (39%), Positives = 184/307 (59%), Gaps = 12/307 (3%) Query: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEI--LSVLSHRNIIQ 67 ++ F+++ + G G+ G+V+ ++ +EVAVKK+ + KE +I L L H NII Sbjct: 119 EVPFEEILDLQWVGSGAQGAVFLGRF--HGEEVAVKKVRDL-KETDIKHLRKLKHPNIIT 175 Query: 68 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127 F GV + P Y I+ E+ + G LY+ + + R + ++ W+ +A GM+YLH+ Sbjct: 176 FKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSL--LVDWSMGIAGGMNYLHLH--- 230 Query: 128 KVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSET 186 K+IHRDLKS N++I D V+KI DFG S+ + +T MS GT WMAPEVI++ PVSE Sbjct: 231 KIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK 290 Query: 187 CDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEAD 246 D +S+GVVLWE+LT E+P+K ++ + W V + L +PSSCP F LL QCW + Sbjct: 291 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSK 350 Query: 247 AKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQ 306 + RPSF+QI+ L+ S D L ++ ++AEWR E++ E++K L E+ Sbjct: 351 PRNRPSFRQILLHLDIASADV-LSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEE 409 Query: 307 ELKERER 313 EL R R Sbjct: 410 ELVMRRR 416 >gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo sapiens] Length = 966 Score = 209 bits (531), Expect = 5e-54 Identities = 133/402 (33%), Positives = 217/402 (53%), Gaps = 28/402 (6%) Query: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKI-EKEAEILSVLSHRNIIQF 68 ++ F+++ + G G+ G+V+ K+ ++ EVA+KK+ + E + + L L H NII F Sbjct: 162 EVPFEEISELQWLGSGAQGAVFLGKFRAE--EVAIKKVREQNETDIKHLRKLKHPNIIAF 219 Query: 69 YGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVK 128 GV + P Y I+ EY + G LY+ + + R + ++ W+T +A GM+YLH+ K Sbjct: 220 KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRL--LVDWSTGIASGMNYLHLH---K 274 Query: 129 VIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSETC 187 +IHRDLKS NV++ +KI DFG S+ + +T MS GT WMAPEVI++ PVSE Sbjct: 275 IIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKV 334 Query: 188 DTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADA 247 D +S+GVVLWE+LT E+P+K ++ + W V + L +PS+CP F L+ Q W++ Sbjct: 335 DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKP 394 Query: 248 KKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQE 307 + RPSF+Q + L+ S D L ++ ++AEWR E++ E++K + ++E Sbjct: 395 RNRPSFRQTLMHLDIASADV-LATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEE 453 Query: 308 LKERERR--------LKMWEQKLTEQSNTPLLLPLAARMSEESYFESKTEESNSAEMSCQ 359 L R R + +E+KL +N L + L+A M + E + +E E + + Sbjct: 454 LIRRRREELRHALDIREHYERKLERANN--LYMELSAIMLQ---LEMREKELIKREQAVE 508 Query: 360 ITATSNGEGHGMNPSLQAMMLMGFGDIFSMNKAGAVMHSGMQ 401 + H + P + + M + G SGMQ Sbjct: 509 KKYPGTYKRHPVRPIIHPNAMEKL-----MKRKGVPHKSGMQ 545 >gi|21735566 mitogen-activated protein kinase kinase kinase 7 isoform D [Homo sapiens] Length = 491 Score = 171 bits (432), Expect = 2e-42 Identities = 126/414 (30%), Positives = 205/414 (49%), Gaps = 58/414 (14%) Query: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-LKIEKEAEI-----LSVL 60 +F +I + +++ E G G+FG V +AKW + K+VA+K++ + E++A I LS + Sbjct: 27 NFEEIDYKEIEVEEVVGRGAFGVVCKAKW--RAKDVAIKQIESESERKAFIVELRQLSRV 84 Query: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS-EEMDMDHIMTWATDVAKGMH 119 +H NI++ YG L P +V EYA GSLY+ ++ H M+W ++G+ Sbjct: 85 NHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142 Query: 120 YLHMEAPVKVIHRDLKSRNVVIAADG-VLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEV 177 YLH P +IHRDLK N+++ A G VLKICDFG A H T+ G+ WMAPEV Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEV 200 Query: 178 IQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG--LQVAWLVVEKNERLTIPSSCPRSF 235 + SE CD +S+G++LWE++TR PF + G ++ W V R + + P+ Sbjct: 201 FEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMW-AVHNGTRPPLIKNLPKPI 259 Query: 236 AELLHQCWEADAKKRPSFKQIISIL----------------------ESMSNDT----SL 269 L+ +CW D +RPS ++I+ I+ E SN S Sbjct: 260 ESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSF 319 Query: 270 PDKCNSFLHNKAEWRCE-IEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNT 328 D ++ NK++ E + AT + +K+LE L + + + RL + + + + Sbjct: 320 MDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESL 379 Query: 329 PLLLPLAARMSEESYFESKTEESNSAEMSCQITATSNGEGHGMNPSLQAMMLMG 382 P P + E K ++ +E+ +I AT+ G G S+Q + + G Sbjct: 380 P---PTS---------EGKRMSADMSEIEARIAATT-GNGQPRRRSIQDLTVTG 420 >gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform A [Homo sapiens] Length = 579 Score = 171 bits (432), Expect = 2e-42 Identities = 126/414 (30%), Positives = 205/414 (49%), Gaps = 58/414 (14%) Query: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-LKIEKEAEI-----LSVL 60 +F +I + +++ E G G+FG V +AKW + K+VA+K++ + E++A I LS + Sbjct: 27 NFEEIDYKEIEVEEVVGRGAFGVVCKAKW--RAKDVAIKQIESESERKAFIVELRQLSRV 84 Query: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS-EEMDMDHIMTWATDVAKGMH 119 +H NI++ YG L P +V EYA GSLY+ ++ H M+W ++G+ Sbjct: 85 NHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142 Query: 120 YLHMEAPVKVIHRDLKSRNVVIAADG-VLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEV 177 YLH P +IHRDLK N+++ A G VLKICDFG A H T+ G+ WMAPEV Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEV 200 Query: 178 IQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG--LQVAWLVVEKNERLTIPSSCPRSF 235 + SE CD +S+G++LWE++TR PF + G ++ W V R + + P+ Sbjct: 201 FEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMW-AVHNGTRPPLIKNLPKPI 259 Query: 236 AELLHQCWEADAKKRPSFKQIISIL----------------------ESMSNDT----SL 269 L+ +CW D +RPS ++I+ I+ E SN S Sbjct: 260 ESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSF 319 Query: 270 PDKCNSFLHNKAEWRCE-IEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNT 328 D ++ NK++ E + AT + +K+LE L + + + RL + + + + Sbjct: 320 MDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESL 379 Query: 329 PLLLPLAARMSEESYFESKTEESNSAEMSCQITATSNGEGHGMNPSLQAMMLMG 382 P P + E K ++ +E+ +I AT+ G G S+Q + + G Sbjct: 380 P---PTS---------EGKRMSADMSEIEARIAATT-GNGQPRRRSIQDLTVTG 420 >gi|21735564 mitogen-activated protein kinase kinase kinase 7 isoform C [Homo sapiens] Length = 518 Score = 166 bits (421), Expect = 3e-41 Identities = 121/396 (30%), Positives = 197/396 (49%), Gaps = 57/396 (14%) Query: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-LKIEKEAEI-----LSVL 60 +F +I + +++ E G G+FG V +AKW + K+VA+K++ + E++A I LS + Sbjct: 27 NFEEIDYKEIEVEEVVGRGAFGVVCKAKW--RAKDVAIKQIESESERKAFIVELRQLSRV 84 Query: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS-EEMDMDHIMTWATDVAKGMH 119 +H NI++ YG L P +V EYA GSLY+ ++ H M+W ++G+ Sbjct: 85 NHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142 Query: 120 YLHMEAPVKVIHRDLKSRNVVIAADG-VLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEV 177 YLH P +IHRDLK N+++ A G VLKICDFG A H T+ G+ WMAPEV Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEV 200 Query: 178 IQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG--LQVAWLVVEKNERLTIPSSCPRSF 235 + SE CD +S+G++LWE++TR PF + G ++ W V R + + P+ Sbjct: 201 FEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMW-AVHNGTRPPLIKNLPKPI 259 Query: 236 AELLHQCWEADAKKRPSFKQIISIL----------------------ESMSNDT----SL 269 L+ +CW D +RPS ++I+ I+ E SN S Sbjct: 260 ESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSF 319 Query: 270 PDKCNSFLHNKAEWRCE-IEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNT 328 D ++ NK++ E + AT + +K+LE L + + + RL + + + + Sbjct: 320 MDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESL 379 Query: 329 PLLLPLAARMSEESYFESKTEESNSAEMSCQITATS 364 P P + E K ++ +E+ +I AT+ Sbjct: 380 P---PTS---------EGKRMSADMSEIEARIAATT 403 >gi|21735562 mitogen-activated protein kinase kinase kinase 7 isoform B [Homo sapiens] Length = 606 Score = 166 bits (421), Expect = 3e-41 Identities = 121/396 (30%), Positives = 197/396 (49%), Gaps = 57/396 (14%) Query: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-LKIEKEAEI-----LSVL 60 +F +I + +++ E G G+FG V +AKW + K+VA+K++ + E++A I LS + Sbjct: 27 NFEEIDYKEIEVEEVVGRGAFGVVCKAKW--RAKDVAIKQIESESERKAFIVELRQLSRV 84 Query: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS-EEMDMDHIMTWATDVAKGMH 119 +H NI++ YG L P +V EYA GSLY+ ++ H M+W ++G+ Sbjct: 85 NHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142 Query: 120 YLHMEAPVKVIHRDLKSRNVVIAADG-VLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEV 177 YLH P +IHRDLK N+++ A G VLKICDFG A H T+ G+ WMAPEV Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEV 200 Query: 178 IQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG--LQVAWLVVEKNERLTIPSSCPRSF 235 + SE CD +S+G++LWE++TR PF + G ++ W V R + + P+ Sbjct: 201 FEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMW-AVHNGTRPPLIKNLPKPI 259 Query: 236 AELLHQCWEADAKKRPSFKQIISIL----------------------ESMSNDT----SL 269 L+ +CW D +RPS ++I+ I+ E SN S Sbjct: 260 ESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSF 319 Query: 270 PDKCNSFLHNKAEWRCE-IEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNT 328 D ++ NK++ E + AT + +K+LE L + + + RL + + + + Sbjct: 320 MDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESL 379 Query: 329 PLLLPLAARMSEESYFESKTEESNSAEMSCQITATS 364 P P + E K ++ +E+ +I AT+ Sbjct: 380 P---PTS---------EGKRMSADMSEIEARIAATT 403 >gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a [Homo sapiens] Length = 1130 Score = 154 bits (389), Expect = 2e-37 Identities = 88/269 (32%), Positives = 145/269 (53%), Gaps = 15/269 (5%) Query: 15 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67 D+ GGG +G VY W VAVK L +++E KEA ++ + H N++Q Sbjct: 241 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 300 Query: 68 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127 GV P + I+TE+ + G+L DY+ +E++ ++ AT ++ M YL + Sbjct: 301 LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK--- 357 Query: 128 KVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPVS 184 IHRDL +RN ++ + ++K+ DFG SR T+ + G FP W APE + S Sbjct: 358 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS 417 Query: 185 ETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCW 243 D +++GV+LWE+ T + P+ G++ QV + ++EK+ R+ P CP EL+ CW Sbjct: 418 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YELLEKDYRMERPEGCPEKVYELMRACW 476 Query: 244 EADAKKRPSFKQIISILESMSNDTSLPDK 272 + + RPSF +I E+M ++S+ D+ Sbjct: 477 QWNPSDRPSFAEIHQAFETMFQESSISDE 505 >gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b [Homo sapiens] Length = 1149 Score = 154 bits (389), Expect = 2e-37 Identities = 88/269 (32%), Positives = 145/269 (53%), Gaps = 15/269 (5%) Query: 15 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67 D+ GGG +G VY W VAVK L +++E KEA ++ + H N++Q Sbjct: 260 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 319 Query: 68 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127 GV P + I+TE+ + G+L DY+ +E++ ++ AT ++ M YL + Sbjct: 320 LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK--- 376 Query: 128 KVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPVS 184 IHRDL +RN ++ + ++K+ DFG SR T+ + G FP W APE + S Sbjct: 377 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS 436 Query: 185 ETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCW 243 D +++GV+LWE+ T + P+ G++ QV + ++EK+ R+ P CP EL+ CW Sbjct: 437 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YELLEKDYRMERPEGCPEKVYELMRACW 495 Query: 244 EADAKKRPSFKQIISILESMSNDTSLPDK 272 + + RPSF +I E+M ++S+ D+ Sbjct: 496 QWNPSDRPSFAEIHQAFETMFQESSISDE 524 >gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] Length = 1167 Score = 151 bits (382), Expect = 1e-36 Identities = 95/270 (35%), Positives = 144/270 (53%), Gaps = 17/270 (6%) Query: 15 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67 D+ GGG +G VY W VAVK L +++E KEA ++ + H N++Q Sbjct: 272 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 331 Query: 68 FYGVI-LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 126 GV LEPP Y IVTEY G+L DY+ EE+ ++ AT ++ M YL + Sbjct: 332 LLGVCTLEPPFY-IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK-- 388 Query: 127 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPV 183 IHRDL +RN ++ + V+K+ DFG SR T+ + G FP W APE + Sbjct: 389 -NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTF 447 Query: 184 SETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQC 242 S D +++GV+LWE+ T + P+ G++ QV + ++EK R+ P CP EL+ C Sbjct: 448 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YDLLEKGYRMEQPEGCPPKVYELMRAC 506 Query: 243 WEADAKKRPSFKQIISILESMSNDTSLPDK 272 W+ RPSF + E+M +D+S+ ++ Sbjct: 507 WKWSPADRPSFAETHQAFETMFHDSSISEE 536 >gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] Length = 1182 Score = 151 bits (382), Expect = 1e-36 Identities = 95/270 (35%), Positives = 144/270 (53%), Gaps = 17/270 (6%) Query: 15 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67 D+ GGG +G VY W VAVK L +++E KEA ++ + H N++Q Sbjct: 287 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 346 Query: 68 FYGVI-LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 126 GV LEPP Y IVTEY G+L DY+ EE+ ++ AT ++ M YL + Sbjct: 347 LLGVCTLEPPFY-IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK-- 403 Query: 127 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPV 183 IHRDL +RN ++ + V+K+ DFG SR T+ + G FP W APE + Sbjct: 404 -NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTF 462 Query: 184 SETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQC 242 S D +++GV+LWE+ T + P+ G++ QV + ++EK R+ P CP EL+ C Sbjct: 463 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YDLLEKGYRMEQPEGCPPKVYELMRAC 521 Query: 243 WEADAKKRPSFKQIISILESMSNDTSLPDK 272 W+ RPSF + E+M +D+S+ ++ Sbjct: 522 WKWSPADRPSFAETHQAFETMFHDSSISEE 551 >gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] Length = 1064 Score = 151 bits (382), Expect = 1e-36 Identities = 95/270 (35%), Positives = 144/270 (53%), Gaps = 17/270 (6%) Query: 15 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67 D+ GGG +G VY W VAVK L +++E KEA ++ + H N++Q Sbjct: 272 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 331 Query: 68 FYGVI-LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 126 GV LEPP Y IVTEY G+L DY+ EE+ ++ AT ++ M YL + Sbjct: 332 LLGVCTLEPPFY-IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK-- 388 Query: 127 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPV 183 IHRDL +RN ++ + V+K+ DFG SR T+ + G FP W APE + Sbjct: 389 -NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTF 447 Query: 184 SETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQC 242 S D +++GV+LWE+ T + P+ G++ QV + ++EK R+ P CP EL+ C Sbjct: 448 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YDLLEKGYRMEQPEGCPPKVYELMRAC 506 Query: 243 WEADAKKRPSFKQIISILESMSNDTSLPDK 272 W+ RPSF + E+M +D+S+ ++ Sbjct: 507 WKWSPADRPSFAETHQAFETMFHDSSISEE 536 >gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] Length = 1146 Score = 151 bits (382), Expect = 1e-36 Identities = 95/270 (35%), Positives = 144/270 (53%), Gaps = 17/270 (6%) Query: 15 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67 D+ GGG +G VY W VAVK L +++E KEA ++ + H N++Q Sbjct: 251 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 310 Query: 68 FYGVI-LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 126 GV LEPP Y IVTEY G+L DY+ EE+ ++ AT ++ M YL + Sbjct: 311 LLGVCTLEPPFY-IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK-- 367 Query: 127 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPV 183 IHRDL +RN ++ + V+K+ DFG SR T+ + G FP W APE + Sbjct: 368 -NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTF 426 Query: 184 SETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQC 242 S D +++GV+LWE+ T + P+ G++ QV + ++EK R+ P CP EL+ C Sbjct: 427 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YDLLEKGYRMEQPEGCPPKVYELMRAC 485 Query: 243 WEADAKKRPSFKQIISILESMSNDTSLPDK 272 W+ RPSF + E+M +D+S+ ++ Sbjct: 486 WKWSPADRPSFAETHQAFETMFHDSSISEE 515 >gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] Length = 542 Score = 151 bits (381), Expect = 1e-36 Identities = 95/269 (35%), Positives = 143/269 (53%), Gaps = 17/269 (6%) Query: 15 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67 D+ GGG +G VY W VAVK L +++E KEA ++ + H N++Q Sbjct: 266 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 325 Query: 68 FYGVI-LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 126 GV LEPP Y IVTEY G+L DY+ EE+ ++ AT ++ M YL + Sbjct: 326 LLGVCTLEPPFY-IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK-- 382 Query: 127 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPV 183 IHRDL +RN ++ + V+K+ DFG SR T+ + G FP W APE + Sbjct: 383 -NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTF 441 Query: 184 SETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQC 242 S D +++GV+LWE+ T + P+ G++ QV + ++EK R+ P CP EL+ C Sbjct: 442 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YDLLEKGYRMEQPEGCPPKVYELMRAC 500 Query: 243 WEADAKKRPSFKQIISILESMSNDTSLPD 271 W+ RPSF + E+M +D+S+ + Sbjct: 501 WKWSPADRPSFAETHQAFETMFHDSSISE 529 >gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] Length = 537 Score = 143 bits (360), Expect = 4e-34 Identities = 88/263 (33%), Positives = 137/263 (52%), Gaps = 17/263 (6%) Query: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLL-------KIEKEAEILSVLSH 62 +I + LQ + G G FG V+ W K VA+K L +EA+I+ L H Sbjct: 265 EIPRESLQLIKRLGNGQFGEVWMGTWNGNTK-VAIKTLKPGTMSPESFLEEAQIMKKLKH 323 Query: 63 RNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLH 122 ++Q Y V+ E P Y IVTEY + GSL D++ + + +++ A VA GM Y+ Sbjct: 324 DKLVQLYAVVSEEPIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 382 Query: 123 MEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQ 179 + IHRDL+S N+++ + KI DFG +R + + G FP W APE Sbjct: 383 R---MNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 439 Query: 180 SLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAEL 238 + D +S+G++L E++T+ VP+ G+ +V V E+ R+ P CP S EL Sbjct: 440 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV-ERGYRMPCPQDCPISLHEL 498 Query: 239 LHQCWEADAKKRPSFKQIISILE 261 + CW+ D ++RP+F+ + S LE Sbjct: 499 MIHCWKKDPEERPTFEYLQSFLE 521 >gi|4503787 fyn-related kinase [Homo sapiens] Length = 505 Score = 143 bits (360), Expect = 4e-34 Identities = 91/283 (32%), Positives = 146/283 (51%), Gaps = 21/283 (7%) Query: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEKEAEILSVLSH 62 +I + +Q + G G FG V+ W + VAVK L +EA+I+ L H Sbjct: 228 EIDRNSIQLLKRLGSGQFGEVWEGLW-NNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRH 286 Query: 63 RNIIQFYGVI-LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYL 121 +IQ Y V LE P Y I+TE GSL +Y+ ++ ++ + + A VA GM YL Sbjct: 287 PKLIQLYAVCTLEDPIY-IITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYL 345 Query: 122 HMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHN------HTTHMSLVGTFPWMAP 175 IHRDL +RNV++ + K+ DFG +R + + + W AP Sbjct: 346 ESR---NYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAP 402 Query: 176 EVIQSLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRS 234 E I+S S D +S+G++L+E++T ++P+ G+ G QV ++ + N RL PS+CP+ Sbjct: 403 EAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQ-NYRLPQPSNCPQQ 461 Query: 235 FAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFL 277 F ++ +CW A+ K+RP+F+ + LE S N+F+ Sbjct: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFI 504 >gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] Length = 835 Score = 141 bits (356), Expect = 1e-33 Identities = 93/271 (34%), Positives = 139/271 (51%), Gaps = 20/271 (7%) Query: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----------KEAE 55 S ++ +++F E G GSFG VY+ + ++K VA+K+ +E Sbjct: 454 SHFHLQLSEIEFHEIIGSGSFGKVYKGR--CRNKIVAIKRYRANTYCSKSDVDMFCREVS 511 Query: 56 ILSVLSHRNIIQFYGVIL-EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDV 114 IL L+H +IQF G L +P + IVT+Y S GSL+ ++ + +D+ + A DV Sbjct: 512 ILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQK-RILDLQSKLIIAVDV 570 Query: 115 AKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLV---GTFP 171 AKGM YLH +IHRDL S N+++ DG + DFG SRF ++ G Sbjct: 571 AKGMEYLH-NLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLR 629 Query: 172 WMAPEVI-QSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSS 230 WMAPEV Q + D +SY + LWE+LT E+PF L+ A + + R I S Sbjct: 630 WMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYS 689 Query: 231 CPRSFAELLHQCWEADAKKRPSFKQIISILE 261 P+ + LL + W A + RP F +++ LE Sbjct: 690 IPKPISSLLIRGWNACPEGRPEFSEVVMKLE 720 >gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] Length = 936 Score = 141 bits (356), Expect = 1e-33 Identities = 93/271 (34%), Positives = 139/271 (51%), Gaps = 20/271 (7%) Query: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----------KEAE 55 S ++ +++F E G GSFG VY+ + ++K VA+K+ +E Sbjct: 555 SHFHLQLSEIEFHEIIGSGSFGKVYKGR--CRNKIVAIKRYRANTYCSKSDVDMFCREVS 612 Query: 56 ILSVLSHRNIIQFYGVIL-EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDV 114 IL L+H +IQF G L +P + IVT+Y S GSL+ ++ + +D+ + A DV Sbjct: 613 ILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQK-RILDLQSKLIIAVDV 671 Query: 115 AKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLV---GTFP 171 AKGM YLH +IHRDL S N+++ DG + DFG SRF ++ G Sbjct: 672 AKGMEYLH-NLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLR 730 Query: 172 WMAPEVI-QSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSS 230 WMAPEV Q + D +SY + LWE+LT E+PF L+ A + + R I S Sbjct: 731 WMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYS 790 Query: 231 CPRSFAELLHQCWEADAKKRPSFKQIISILE 261 P+ + LL + W A + RP F +++ LE Sbjct: 791 IPKPISSLLIRGWNACPEGRPEFSEVVMKLE 821 Score = 29.6 bits (65), Expect = 5.9 Identities = 18/44 (40%), Positives = 28/44 (63%), Gaps = 4/44 (9%) Query: 271 DKCNSF---LHNKAEWRCEI-EATLERLKKLERDLSFKEQELKE 310 DK NSF L + EW+ ++ E+ + +++LE DL KE+EL E Sbjct: 102 DKWNSFTILLIHSDEWKKKVSESYVITIERLEDDLQIKEKELTE 145 >gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sapiens] Length = 1038 Score = 140 bits (353), Expect = 2e-33 Identities = 94/273 (34%), Positives = 142/273 (52%), Gaps = 26/273 (9%) Query: 15 DLQFFENCGGGSFGSVYRAKWISQD-KEVAVK-KLLKIE------------KEAEILSVL 60 DL+ E G GSFG V R +W + K V+V K LK + +E + L Sbjct: 125 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 184 Query: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120 HRN+I+ YGV+L PP +VTE A LGSL D + ++ + + + +A VA+GM Y Sbjct: 185 DHRNLIRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAEGMGY 242 Query: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF-----HNHTTHMSLVGTFPWMAP 175 L + + IHRDL +RN+++A ++KI DFG R ++ F W AP Sbjct: 243 LESK---RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 299 Query: 176 EVIQSLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRS 234 E +++ S DT+ +GV LWEM T + P+ GL G Q+ + ++ ERL P CP+ Sbjct: 300 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 359 Query: 235 FAELLHQCWEADAKKRPSFKQIIS-ILESMSND 266 ++ QCW + RP+F + +LE+ D Sbjct: 360 IYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTD 392 >gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sapiens] Length = 1086 Score = 140 bits (353), Expect = 2e-33 Identities = 94/273 (34%), Positives = 142/273 (52%), Gaps = 26/273 (9%) Query: 15 DLQFFENCGGGSFGSVYRAKWISQD-KEVAVK-KLLKIE------------KEAEILSVL 60 DL+ E G GSFG V R +W + K V+V K LK + +E + L Sbjct: 188 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 247 Query: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120 HRN+I+ YGV+L PP +VTE A LGSL D + ++ + + + +A VA+GM Y Sbjct: 248 DHRNLIRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAEGMGY 305 Query: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF-----HNHTTHMSLVGTFPWMAP 175 L + + IHRDL +RN+++A ++KI DFG R ++ F W AP Sbjct: 306 LESK---RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 362 Query: 176 EVIQSLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRS 234 E +++ S DT+ +GV LWEM T + P+ GL G Q+ + ++ ERL P CP+ Sbjct: 363 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 422 Query: 235 FAELLHQCWEADAKKRPSFKQIIS-ILESMSND 266 ++ QCW + RP+F + +LE+ D Sbjct: 423 IYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTD 455 >gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] Length = 675 Score = 135 bits (341), Expect = 6e-32 Identities = 86/272 (31%), Positives = 146/272 (53%), Gaps = 17/272 (6%) Query: 3 SLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEKEAE 55 SLG ++K +++ + G G FG V KW Q +VAVK + + +EA+ Sbjct: 404 SLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQ-YDVAVKMIKEGSMSEDEFFQEAQ 462 Query: 56 ILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVA 115 + LSH +++FYGV + IVTEY S G L +Y+ S+ + ++ ++ DV Sbjct: 463 TMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSH-GKGLEPSQLLEMCYDVC 521 Query: 116 KGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--W 172 +GM +L + IHRDL +RN ++ D +K+ DFG +R+ ++S VGT FP W Sbjct: 522 EGMAFLESH---QFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKW 578 Query: 173 MAPEVIQSLPVSETCDTYSYGVVLWEMLT-REVPFKGLEGLQVAWLVVEKNERLTIPSSC 231 APEV S D +++G+++WE+ + + P+ + QV L V + RL P Sbjct: 579 SAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVV-LKVSQGHRLYRPHLA 637 Query: 232 PRSFAELLHQCWEADAKKRPSFKQIISILESM 263 + ++++ CW +KRP+F+Q++S +E + Sbjct: 638 SDTIYQIMYSCWHELPEKRPTFQQLLSSIEPL 669 >gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] Length = 675 Score = 135 bits (341), Expect = 6e-32 Identities = 86/272 (31%), Positives = 146/272 (53%), Gaps = 17/272 (6%) Query: 3 SLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEKEAE 55 SLG ++K +++ + G G FG V KW Q +VAVK + + +EA+ Sbjct: 404 SLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQ-YDVAVKMIKEGSMSEDEFFQEAQ 462 Query: 56 ILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVA 115 + LSH +++FYGV + IVTEY S G L +Y+ S+ + ++ ++ DV Sbjct: 463 TMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSH-GKGLEPSQLLEMCYDVC 521 Query: 116 KGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--W 172 +GM +L + IHRDL +RN ++ D +K+ DFG +R+ ++S VGT FP W Sbjct: 522 EGMAFLESH---QFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKW 578 Query: 173 MAPEVIQSLPVSETCDTYSYGVVLWEMLT-REVPFKGLEGLQVAWLVVEKNERLTIPSSC 231 APEV S D +++G+++WE+ + + P+ + QV L V + RL P Sbjct: 579 SAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVV-LKVSQGHRLYRPHLA 637 Query: 232 PRSFAELLHQCWEADAKKRPSFKQIISILESM 263 + ++++ CW +KRP+F+Q++S +E + Sbjct: 638 SDTIYQIMYSCWHELPEKRPTFQQLLSSIEPL 669 >gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] Length = 534 Score = 134 bits (337), Expect = 2e-31 Identities = 84/250 (33%), Positives = 130/250 (52%), Gaps = 17/250 (6%) Query: 23 GGGSFGSVYRAKWISQDKEVAVKKLL-------KIEKEAEILSVLSHRNIIQFYGVILEP 75 G G F V+ W K VA+K L +EA+I+ L H ++Q Y V+ E Sbjct: 275 GQGCFAEVWLGTWNGNTK-VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEE 333 Query: 76 PNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLK 135 P Y IVTEY + GSL D++ + + +++ A VA GM Y+ + IHRDL+ Sbjct: 334 PIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER---MNYIHRDLR 389 Query: 136 SRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPVSETCDTYSY 192 S N+++ + KI DFG +R + + G FP W APE + D +S+ Sbjct: 390 SANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 449 Query: 193 GVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRP 251 G++L E++T+ VP+ G+ +V V E+ R+ P CP S EL+ CW+ D ++RP Sbjct: 450 GILLTELVTKGRVPYPGMNNREVLEQV-ERGYRMPCPQDCPISLHELMIHCWKKDPEERP 508 Query: 252 SFKQIISILE 261 +F+ + S LE Sbjct: 509 TFEYLQSFLE 518 >gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sapiens] Length = 536 Score = 132 bits (333), Expect = 5e-31 Identities = 82/269 (30%), Positives = 137/269 (50%), Gaps = 17/269 (6%) Query: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEKEAEILSVLSH 62 +I + L+ G G FG V+ W + VA+K L +EA+++ L H Sbjct: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRH 322 Query: 63 RNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLH 122 ++Q Y V+ E P Y IVTEY S GSL D++ + + + ++ A +A GM Y+ Sbjct: 323 EKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 Query: 123 MEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQ 179 + +HRDL++ N+++ + V K+ DFG +R + + G FP W APE Sbjct: 382 R---MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 Query: 180 SLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAEL 238 + D +S+G++L E+ T+ VP+ G+ +V V E+ R+ P CP S +L Sbjct: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLHDL 497 Query: 239 LHQCWEADAKKRPSFKQIISILESMSNDT 267 + QCW + ++RP+F+ + + LE T Sbjct: 498 MCQCWRKEPEERPTFEYLQAFLEDYFTST 526 >gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapiens] Length = 536 Score = 132 bits (333), Expect = 5e-31 Identities = 82/269 (30%), Positives = 137/269 (50%), Gaps = 17/269 (6%) Query: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEKEAEILSVLSH 62 +I + L+ G G FG V+ W + VA+K L +EA+++ L H Sbjct: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRH 322 Query: 63 RNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLH 122 ++Q Y V+ E P Y IVTEY S GSL D++ + + + ++ A +A GM Y+ Sbjct: 323 EKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 Query: 123 MEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQ 179 + +HRDL++ N+++ + V K+ DFG +R + + G FP W APE Sbjct: 382 R---MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 Query: 180 SLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAEL 238 + D +S+G++L E+ T+ VP+ G+ +V V E+ R+ P CP S +L Sbjct: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLHDL 497 Query: 239 LHQCWEADAKKRPSFKQIISILESMSNDT 267 + QCW + ++RP+F+ + + LE T Sbjct: 498 MCQCWRKEPEERPTFEYLQAFLEDYFTST 526 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.131 0.382 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,960,987 Number of Sequences: 37866 Number of extensions: 724217 Number of successful extensions: 9743 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 713 Number of HSP's successfully gapped in prelim test: 235 Number of HSP's that attempted gapping in prelim test: 5733 Number of HSP's gapped (non-prelim): 2030 length of query: 455 length of database: 18,247,518 effective HSP length: 106 effective length of query: 349 effective length of database: 14,233,722 effective search space: 4967568978 effective search space used: 4967568978 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.