Guide to the Human Genome
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Search of human proteins with 19526767

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
         (455 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]               919   0.0  
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]               673   0.0  
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho...   228   1e-59
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H...   225   7e-59
gi|155723000 mixed lineage kinase 4 [Homo sapiens]                    223   2e-58
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho...   218   7e-57
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H...   213   3e-55
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho...   209   5e-54
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso...   171   2e-42
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof...   171   2e-42
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso...   166   3e-41
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso...   166   3e-41
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   154   2e-37
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   154   2e-37
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             151   1e-36
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               151   1e-36
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             151   1e-36
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             151   1e-36
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             151   1e-36
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]       143   4e-34
gi|4503787 fyn-related kinase [Homo sapiens]                          143   4e-34
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]          141   1e-33
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]        141   1e-33
gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sap...   140   2e-33
gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sap...   140   2e-33
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]            135   6e-32
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]           135   6e-32
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]      134   2e-31
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap...   132   5e-31
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi...   132   5e-31

>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
          Length = 455

 Score =  919 bits (2375), Expect = 0.0
 Identities = 455/455 (100%), Positives = 455/455 (100%)

Query: 1   MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL 60
           MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
Sbjct: 1   MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL 60

Query: 61  SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120
           SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
Sbjct: 61  SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120

Query: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS 180
           LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
Sbjct: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS 180

Query: 181 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH 240
           LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
Sbjct: 181 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH 240

Query: 241 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD 300
           QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
Sbjct: 241 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD 300

Query: 301 LSFKEQELKERERRLKMWEQKLTEQSNTPLLLPLAARMSEESYFESKTEESNSAEMSCQI 360
           LSFKEQELKERERRLKMWEQKLTEQSNTPLLLPLAARMSEESYFESKTEESNSAEMSCQI
Sbjct: 301 LSFKEQELKERERRLKMWEQKLTEQSNTPLLLPLAARMSEESYFESKTEESNSAEMSCQI 360

Query: 361 TATSNGEGHGMNPSLQAMMLMGFGDIFSMNKAGAVMHSGMQINMQAKQNSSKTTSKRRGK 420
           TATSNGEGHGMNPSLQAMMLMGFGDIFSMNKAGAVMHSGMQINMQAKQNSSKTTSKRRGK
Sbjct: 361 TATSNGEGHGMNPSLQAMMLMGFGDIFSMNKAGAVMHSGMQINMQAKQNSSKTTSKRRGK 420

Query: 421 KVNMALGFSDFDLSEGDDDDDDDGEEEDNDMDNSE 455
           KVNMALGFSDFDLSEGDDDDDDDGEEEDNDMDNSE
Sbjct: 421 KVNMALGFSDFDLSEGDDDDDDDGEEEDNDMDNSE 455


>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
          Length = 800

 Score =  673 bits (1737), Expect = 0.0
 Identities = 331/331 (100%), Positives = 331/331 (100%)

Query: 1   MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL 60
           MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
Sbjct: 1   MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL 60

Query: 61  SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120
           SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
Sbjct: 61  SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120

Query: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS 180
           LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
Sbjct: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS 180

Query: 181 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH 240
           LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
Sbjct: 181 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH 240

Query: 241 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD 300
           QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
Sbjct: 241 QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD 300

Query: 301 LSFKEQELKERERRLKMWEQKLTEQSNTPLL 331
           LSFKEQELKERERRLKMWEQKLTEQSNTPLL
Sbjct: 301 LSFKEQELKERERRLKMWEQKLTEQSNTPLL 331


>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
           sapiens]
          Length = 1118

 Score =  228 bits (580), Expect = 1e-59
 Identities = 135/344 (39%), Positives = 195/344 (56%), Gaps = 32/344 (9%)

Query: 9   VQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKK------------LLKIEKEAEI 56
           ++I F +L   E  G G FG VYRA WI    EVAVK             +  + +EA++
Sbjct: 137 LEIDFAELTLEEIIGIGGFGKVYRAFWIGD--EVAVKAARHDPDEDISQTIENVRQEAKL 194

Query: 57  LSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAK 116
            ++L H NII   GV L+ PN  +V E+A  G L   ++  R   +  D ++ WA  +A+
Sbjct: 195 FAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR---IPPDILVNWAVQIAR 251

Query: 117 GMHYLHMEAPVKVIHRDLKSRNVVIA--------ADGVLKICDFGASRFHNHTTHMSLVG 168
           GM+YLH EA V +IHRDLKS N++I         ++ +LKI DFG +R  + TT MS  G
Sbjct: 252 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAG 311

Query: 169 TFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIP 228
           T+ WMAPEVI++   S+  D +SYGV+LWE+LT EVPF+G++GL VA+ V      L IP
Sbjct: 312 TYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIP 371

Query: 229 SSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIE 288
           S+CP  FA+L+  CW  D   RPSF  I+  L ++          +SF   +  W+ EI+
Sbjct: 372 STCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQ 431

Query: 289 ATLERLKKLERDLSFKEQEL-------KERERRLKMWEQKLTEQ 325
              ++L+  E++L   E+EL       K +E  L+  EQ+L E+
Sbjct: 432 EMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAER 475


>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
           sapiens]
          Length = 954

 Score =  225 bits (573), Expect = 7e-59
 Identities = 134/343 (39%), Positives = 191/343 (55%), Gaps = 32/343 (9%)

Query: 10  QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLL------------KIEKEAEIL 57
           +I F +LQ  E  G G FG VYRA W  + +EVAVK               ++ +EA + 
Sbjct: 92  EIPFHELQLEEIIGVGGFGKVYRALW--RGEEVAVKAARLDPEKDPAVTAEQVCQEARLF 149

Query: 58  SVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKG 117
             L H NII   G  L PP+  +V EYA  G+L   +   R   +    ++ WA  VA+G
Sbjct: 150 GALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRR---VPPHVLVNWAVQVARG 206

Query: 118 MHYLHMEAPVKVIHRDLKSRNVVIA--------ADGVLKICDFGASRFHNHTTHMSLVGT 169
           M+YLH +APV +IHRDLKS N++I         AD VLKI DFG +R  + TT MS  GT
Sbjct: 207 MNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGT 266

Query: 170 FPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPS 229
           + WMAPEVI+    S++ D +S+GV+LWE+LT EVP++ ++ L VA+ V      L IPS
Sbjct: 267 YAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPS 326

Query: 230 SCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEA 289
           +CP  FA LL +CW+ D   RP F  I+  LE +           SF   + +W+ EI+ 
Sbjct: 327 TCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQH 386

Query: 290 TLERLKKLERDLSFKEQEL-------KERERRLKMWEQKLTEQ 325
             + L+  E++L  +E+EL       + +E +L+  EQ+L E+
Sbjct: 387 MFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAER 429


>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
          Length = 1036

 Score =  223 bits (569), Expect = 2e-58
 Identities = 133/359 (37%), Positives = 198/359 (55%), Gaps = 41/359 (11%)

Query: 6   ASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK------------IEKE 53
           +S V + F+ L+  E  G G FG VYRA W  Q +EVAVK   +            + +E
Sbjct: 114 SSPVHVAFERLELKELIGAGGFGQVYRATW--QGQEVAVKAARQDPEQDAAAAAESVRRE 171

Query: 54  AEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINS------------NRSEE 101
           A + ++L H NII+  GV L+ P+  +V E+A  G+L   + +             R+  
Sbjct: 172 ARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARR 231

Query: 102 MDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIA--------ADGVLKICDFG 153
           +    ++ WA  +A+GM YLH EA V ++HRDLKS N+++          +  LKI DFG
Sbjct: 232 IPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFG 291

Query: 154 ASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQ 213
            +R  + TT MS  GT+ WMAPEVI+S   S+  D +SYGV+LWE+LT EVP++G++GL 
Sbjct: 292 LAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLA 351

Query: 214 VAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKC 273
           VA+ V      L IPS+CP  FA+L+ +CW+ D   RPSF  I+  L ++          
Sbjct: 352 VAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQ 411

Query: 274 NSFLHNKAEWRCEIEATLERLKKLERDLSFKEQEL-------KERERRLKMWEQKLTEQ 325
            SF   + +W+ EI+   + L+  E++L  +E+EL       K +E  LK  EQ+L E+
Sbjct: 412 ESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAER 470


>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
           sapiens]
          Length = 847

 Score =  218 bits (556), Expect = 7e-57
 Identities = 131/352 (37%), Positives = 192/352 (54%), Gaps = 37/352 (10%)

Query: 13  FDDLQFFENCGGGSFGSVYRAKWISQ-----------DKEVAVKKLLKIEKEAEILSVLS 61
           F +L+  E  G G FG VYR  W  +           D++++V     + +EA + ++L+
Sbjct: 114 FQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAE-SVRQEARLFAMLA 172

Query: 62  HRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYL 121
           H NII    V LE PN  +V EYA+ G L   +   R   +    ++ WA  +A+GMHYL
Sbjct: 173 HPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRR---VPPHVLVNWAVQIARGMHYL 229

Query: 122 HMEAPVKVIHRDLKSRNVV----IAADGV----LKICDFGASRFHNHTTHMSLVGTFPWM 173
           H EA V VIHRDLKS N++    I +D +    LKI DFG +R  + TT MS  GT+ WM
Sbjct: 230 HCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWM 289

Query: 174 APEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPR 233
           APEVI++   S+  D +S+GV+LWE+LT EVP++G++ L VA+ V      L IPS+CP 
Sbjct: 290 APEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPE 349

Query: 234 SFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLER 293
            FA+L+  CW  D  +RP F  I+  LE++          +SF   +  W+ EI+   + 
Sbjct: 350 PFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDE 409

Query: 294 LKKLERDLSFKEQE--------------LKERERRLKMWEQKLTEQSNTPLL 331
           L+  E++L  +E+E              L+ RE  L  WE ++ E+  T LL
Sbjct: 410 LRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLL 461


>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
           sapiens]
          Length = 859

 Score =  213 bits (542), Expect = 3e-55
 Identities = 122/307 (39%), Positives = 184/307 (59%), Gaps = 12/307 (3%)

Query: 10  QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEI--LSVLSHRNIIQ 67
           ++ F+++   +  G G+ G+V+  ++    +EVAVKK+  + KE +I  L  L H NII 
Sbjct: 119 EVPFEEILDLQWVGSGAQGAVFLGRF--HGEEVAVKKVRDL-KETDIKHLRKLKHPNIIT 175

Query: 68  FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127
           F GV  + P Y I+ E+ + G LY+ + + R     +  ++ W+  +A GM+YLH+    
Sbjct: 176 FKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSL--LVDWSMGIAGGMNYLHLH--- 230

Query: 128 KVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSET 186
           K+IHRDLKS N++I  D V+KI DFG S+   + +T MS  GT  WMAPEVI++ PVSE 
Sbjct: 231 KIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK 290

Query: 187 CDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEAD 246
            D +S+GVVLWE+LT E+P+K ++   + W V   +  L +PSSCP  F  LL QCW + 
Sbjct: 291 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSK 350

Query: 247 AKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQ 306
            + RPSF+QI+  L+  S D  L     ++  ++AEWR E++   E++K     L   E+
Sbjct: 351 PRNRPSFRQILLHLDIASADV-LSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEE 409

Query: 307 ELKERER 313
           EL  R R
Sbjct: 410 ELVMRRR 416


>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
           sapiens]
          Length = 966

 Score =  209 bits (531), Expect = 5e-54
 Identities = 133/402 (33%), Positives = 217/402 (53%), Gaps = 28/402 (6%)

Query: 10  QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKI-EKEAEILSVLSHRNIIQF 68
           ++ F+++   +  G G+ G+V+  K+ ++  EVA+KK+ +  E + + L  L H NII F
Sbjct: 162 EVPFEEISELQWLGSGAQGAVFLGKFRAE--EVAIKKVREQNETDIKHLRKLKHPNIIAF 219

Query: 69  YGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVK 128
            GV  + P Y I+ EY + G LY+ + + R     +  ++ W+T +A GM+YLH+    K
Sbjct: 220 KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRL--LVDWSTGIASGMNYLHLH---K 274

Query: 129 VIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSETC 187
           +IHRDLKS NV++     +KI DFG S+   + +T MS  GT  WMAPEVI++ PVSE  
Sbjct: 275 IIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKV 334

Query: 188 DTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADA 247
           D +S+GVVLWE+LT E+P+K ++   + W V   +  L +PS+CP  F  L+ Q W++  
Sbjct: 335 DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKP 394

Query: 248 KKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQE 307
           + RPSF+Q +  L+  S D  L     ++  ++AEWR E++   E++K     +   ++E
Sbjct: 395 RNRPSFRQTLMHLDIASADV-LATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEE 453

Query: 308 LKERERR--------LKMWEQKLTEQSNTPLLLPLAARMSEESYFESKTEESNSAEMSCQ 359
           L  R R          + +E+KL   +N  L + L+A M +    E + +E    E + +
Sbjct: 454 LIRRRREELRHALDIREHYERKLERANN--LYMELSAIMLQ---LEMREKELIKREQAVE 508

Query: 360 ITATSNGEGHGMNPSLQAMMLMGFGDIFSMNKAGAVMHSGMQ 401
                  + H + P +    +        M + G    SGMQ
Sbjct: 509 KKYPGTYKRHPVRPIIHPNAMEKL-----MKRKGVPHKSGMQ 545


>gi|21735566 mitogen-activated protein kinase kinase kinase 7
           isoform D [Homo sapiens]
          Length = 491

 Score =  171 bits (432), Expect = 2e-42
 Identities = 126/414 (30%), Positives = 205/414 (49%), Gaps = 58/414 (14%)

Query: 7   SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-LKIEKEAEI-----LSVL 60
           +F +I + +++  E  G G+FG V +AKW  + K+VA+K++  + E++A I     LS +
Sbjct: 27  NFEEIDYKEIEVEEVVGRGAFGVVCKAKW--RAKDVAIKQIESESERKAFIVELRQLSRV 84

Query: 61  SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS-EEMDMDHIMTWATDVAKGMH 119
           +H NI++ YG  L P    +V EYA  GSLY+ ++           H M+W    ++G+ 
Sbjct: 85  NHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142

Query: 120 YLHMEAPVKVIHRDLKSRNVVIAADG-VLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEV 177
           YLH   P  +IHRDLK  N+++ A G VLKICDFG A     H T+    G+  WMAPEV
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEV 200

Query: 178 IQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG--LQVAWLVVEKNERLTIPSSCPRSF 235
            +    SE CD +S+G++LWE++TR  PF  + G   ++ W  V    R  +  + P+  
Sbjct: 201 FEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMW-AVHNGTRPPLIKNLPKPI 259

Query: 236 AELLHQCWEADAKKRPSFKQIISIL----------------------ESMSNDT----SL 269
             L+ +CW  D  +RPS ++I+ I+                      E  SN      S 
Sbjct: 260 ESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSF 319

Query: 270 PDKCNSFLHNKAEWRCE-IEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNT 328
            D  ++   NK++   E + AT + +K+LE  L   + + +    RL +   + +   + 
Sbjct: 320 MDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESL 379

Query: 329 PLLLPLAARMSEESYFESKTEESNSAEMSCQITATSNGEGHGMNPSLQAMMLMG 382
           P   P +         E K   ++ +E+  +I AT+ G G     S+Q + + G
Sbjct: 380 P---PTS---------EGKRMSADMSEIEARIAATT-GNGQPRRRSIQDLTVTG 420


>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
           A [Homo sapiens]
          Length = 579

 Score =  171 bits (432), Expect = 2e-42
 Identities = 126/414 (30%), Positives = 205/414 (49%), Gaps = 58/414 (14%)

Query: 7   SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-LKIEKEAEI-----LSVL 60
           +F +I + +++  E  G G+FG V +AKW  + K+VA+K++  + E++A I     LS +
Sbjct: 27  NFEEIDYKEIEVEEVVGRGAFGVVCKAKW--RAKDVAIKQIESESERKAFIVELRQLSRV 84

Query: 61  SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS-EEMDMDHIMTWATDVAKGMH 119
           +H NI++ YG  L P    +V EYA  GSLY+ ++           H M+W    ++G+ 
Sbjct: 85  NHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142

Query: 120 YLHMEAPVKVIHRDLKSRNVVIAADG-VLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEV 177
           YLH   P  +IHRDLK  N+++ A G VLKICDFG A     H T+    G+  WMAPEV
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEV 200

Query: 178 IQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG--LQVAWLVVEKNERLTIPSSCPRSF 235
            +    SE CD +S+G++LWE++TR  PF  + G   ++ W  V    R  +  + P+  
Sbjct: 201 FEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMW-AVHNGTRPPLIKNLPKPI 259

Query: 236 AELLHQCWEADAKKRPSFKQIISIL----------------------ESMSNDT----SL 269
             L+ +CW  D  +RPS ++I+ I+                      E  SN      S 
Sbjct: 260 ESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSF 319

Query: 270 PDKCNSFLHNKAEWRCE-IEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNT 328
            D  ++   NK++   E + AT + +K+LE  L   + + +    RL +   + +   + 
Sbjct: 320 MDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESL 379

Query: 329 PLLLPLAARMSEESYFESKTEESNSAEMSCQITATSNGEGHGMNPSLQAMMLMG 382
           P   P +         E K   ++ +E+  +I AT+ G G     S+Q + + G
Sbjct: 380 P---PTS---------EGKRMSADMSEIEARIAATT-GNGQPRRRSIQDLTVTG 420


>gi|21735564 mitogen-activated protein kinase kinase kinase 7
           isoform C [Homo sapiens]
          Length = 518

 Score =  166 bits (421), Expect = 3e-41
 Identities = 121/396 (30%), Positives = 197/396 (49%), Gaps = 57/396 (14%)

Query: 7   SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-LKIEKEAEI-----LSVL 60
           +F +I + +++  E  G G+FG V +AKW  + K+VA+K++  + E++A I     LS +
Sbjct: 27  NFEEIDYKEIEVEEVVGRGAFGVVCKAKW--RAKDVAIKQIESESERKAFIVELRQLSRV 84

Query: 61  SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS-EEMDMDHIMTWATDVAKGMH 119
           +H NI++ YG  L P    +V EYA  GSLY+ ++           H M+W    ++G+ 
Sbjct: 85  NHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142

Query: 120 YLHMEAPVKVIHRDLKSRNVVIAADG-VLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEV 177
           YLH   P  +IHRDLK  N+++ A G VLKICDFG A     H T+    G+  WMAPEV
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEV 200

Query: 178 IQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG--LQVAWLVVEKNERLTIPSSCPRSF 235
            +    SE CD +S+G++LWE++TR  PF  + G   ++ W  V    R  +  + P+  
Sbjct: 201 FEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMW-AVHNGTRPPLIKNLPKPI 259

Query: 236 AELLHQCWEADAKKRPSFKQIISIL----------------------ESMSNDT----SL 269
             L+ +CW  D  +RPS ++I+ I+                      E  SN      S 
Sbjct: 260 ESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSF 319

Query: 270 PDKCNSFLHNKAEWRCE-IEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNT 328
            D  ++   NK++   E + AT + +K+LE  L   + + +    RL +   + +   + 
Sbjct: 320 MDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESL 379

Query: 329 PLLLPLAARMSEESYFESKTEESNSAEMSCQITATS 364
           P   P +         E K   ++ +E+  +I AT+
Sbjct: 380 P---PTS---------EGKRMSADMSEIEARIAATT 403


>gi|21735562 mitogen-activated protein kinase kinase kinase 7
           isoform B [Homo sapiens]
          Length = 606

 Score =  166 bits (421), Expect = 3e-41
 Identities = 121/396 (30%), Positives = 197/396 (49%), Gaps = 57/396 (14%)

Query: 7   SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-LKIEKEAEI-----LSVL 60
           +F +I + +++  E  G G+FG V +AKW  + K+VA+K++  + E++A I     LS +
Sbjct: 27  NFEEIDYKEIEVEEVVGRGAFGVVCKAKW--RAKDVAIKQIESESERKAFIVELRQLSRV 84

Query: 61  SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS-EEMDMDHIMTWATDVAKGMH 119
           +H NI++ YG  L P    +V EYA  GSLY+ ++           H M+W    ++G+ 
Sbjct: 85  NHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142

Query: 120 YLHMEAPVKVIHRDLKSRNVVIAADG-VLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEV 177
           YLH   P  +IHRDLK  N+++ A G VLKICDFG A     H T+    G+  WMAPEV
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEV 200

Query: 178 IQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG--LQVAWLVVEKNERLTIPSSCPRSF 235
            +    SE CD +S+G++LWE++TR  PF  + G   ++ W  V    R  +  + P+  
Sbjct: 201 FEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMW-AVHNGTRPPLIKNLPKPI 259

Query: 236 AELLHQCWEADAKKRPSFKQIISIL----------------------ESMSNDT----SL 269
             L+ +CW  D  +RPS ++I+ I+                      E  SN      S 
Sbjct: 260 ESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSF 319

Query: 270 PDKCNSFLHNKAEWRCE-IEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNT 328
            D  ++   NK++   E + AT + +K+LE  L   + + +    RL +   + +   + 
Sbjct: 320 MDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESL 379

Query: 329 PLLLPLAARMSEESYFESKTEESNSAEMSCQITATS 364
           P   P +         E K   ++ +E+  +I AT+
Sbjct: 380 P---PTS---------EGKRMSADMSEIEARIAATT 403


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  154 bits (389), Expect = 2e-37
 Identities = 88/269 (32%), Positives = 145/269 (53%), Gaps = 15/269 (5%)

Query: 15  DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67
           D+      GGG +G VY   W      VAVK L    +++E   KEA ++  + H N++Q
Sbjct: 241 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 300

Query: 68  FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127
             GV    P + I+TE+ + G+L DY+     +E++   ++  AT ++  M YL  +   
Sbjct: 301 LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK--- 357

Query: 128 KVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPVS 184
             IHRDL +RN ++  + ++K+ DFG SR     T+ +  G  FP  W APE +     S
Sbjct: 358 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS 417

Query: 185 ETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCW 243
              D +++GV+LWE+ T  + P+ G++  QV + ++EK+ R+  P  CP    EL+  CW
Sbjct: 418 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YELLEKDYRMERPEGCPEKVYELMRACW 476

Query: 244 EADAKKRPSFKQIISILESMSNDTSLPDK 272
           + +   RPSF +I    E+M  ++S+ D+
Sbjct: 477 QWNPSDRPSFAEIHQAFETMFQESSISDE 505


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  154 bits (389), Expect = 2e-37
 Identities = 88/269 (32%), Positives = 145/269 (53%), Gaps = 15/269 (5%)

Query: 15  DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67
           D+      GGG +G VY   W      VAVK L    +++E   KEA ++  + H N++Q
Sbjct: 260 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 319

Query: 68  FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127
             GV    P + I+TE+ + G+L DY+     +E++   ++  AT ++  M YL  +   
Sbjct: 320 LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK--- 376

Query: 128 KVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPVS 184
             IHRDL +RN ++  + ++K+ DFG SR     T+ +  G  FP  W APE +     S
Sbjct: 377 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS 436

Query: 185 ETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCW 243
              D +++GV+LWE+ T  + P+ G++  QV + ++EK+ R+  P  CP    EL+  CW
Sbjct: 437 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YELLEKDYRMERPEGCPEKVYELMRACW 495

Query: 244 EADAKKRPSFKQIISILESMSNDTSLPDK 272
           + +   RPSF +I    E+M  ++S+ D+
Sbjct: 496 QWNPSDRPSFAEIHQAFETMFQESSISDE 524


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  151 bits (382), Expect = 1e-36
 Identities = 95/270 (35%), Positives = 144/270 (53%), Gaps = 17/270 (6%)

Query: 15  DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67
           D+      GGG +G VY   W      VAVK L    +++E   KEA ++  + H N++Q
Sbjct: 272 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 331

Query: 68  FYGVI-LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 126
             GV  LEPP Y IVTEY   G+L DY+     EE+    ++  AT ++  M YL  +  
Sbjct: 332 LLGVCTLEPPFY-IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK-- 388

Query: 127 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPV 183
              IHRDL +RN ++  + V+K+ DFG SR     T+ +  G  FP  W APE +     
Sbjct: 389 -NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTF 447

Query: 184 SETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQC 242
           S   D +++GV+LWE+ T  + P+ G++  QV + ++EK  R+  P  CP    EL+  C
Sbjct: 448 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YDLLEKGYRMEQPEGCPPKVYELMRAC 506

Query: 243 WEADAKKRPSFKQIISILESMSNDTSLPDK 272
           W+     RPSF +     E+M +D+S+ ++
Sbjct: 507 WKWSPADRPSFAETHQAFETMFHDSSISEE 536


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  151 bits (382), Expect = 1e-36
 Identities = 95/270 (35%), Positives = 144/270 (53%), Gaps = 17/270 (6%)

Query: 15  DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67
           D+      GGG +G VY   W      VAVK L    +++E   KEA ++  + H N++Q
Sbjct: 287 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 346

Query: 68  FYGVI-LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 126
             GV  LEPP Y IVTEY   G+L DY+     EE+    ++  AT ++  M YL  +  
Sbjct: 347 LLGVCTLEPPFY-IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK-- 403

Query: 127 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPV 183
              IHRDL +RN ++  + V+K+ DFG SR     T+ +  G  FP  W APE +     
Sbjct: 404 -NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTF 462

Query: 184 SETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQC 242
           S   D +++GV+LWE+ T  + P+ G++  QV + ++EK  R+  P  CP    EL+  C
Sbjct: 463 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YDLLEKGYRMEQPEGCPPKVYELMRAC 521

Query: 243 WEADAKKRPSFKQIISILESMSNDTSLPDK 272
           W+     RPSF +     E+M +D+S+ ++
Sbjct: 522 WKWSPADRPSFAETHQAFETMFHDSSISEE 551


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  151 bits (382), Expect = 1e-36
 Identities = 95/270 (35%), Positives = 144/270 (53%), Gaps = 17/270 (6%)

Query: 15  DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67
           D+      GGG +G VY   W      VAVK L    +++E   KEA ++  + H N++Q
Sbjct: 272 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 331

Query: 68  FYGVI-LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 126
             GV  LEPP Y IVTEY   G+L DY+     EE+    ++  AT ++  M YL  +  
Sbjct: 332 LLGVCTLEPPFY-IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK-- 388

Query: 127 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPV 183
              IHRDL +RN ++  + V+K+ DFG SR     T+ +  G  FP  W APE +     
Sbjct: 389 -NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTF 447

Query: 184 SETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQC 242
           S   D +++GV+LWE+ T  + P+ G++  QV + ++EK  R+  P  CP    EL+  C
Sbjct: 448 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YDLLEKGYRMEQPEGCPPKVYELMRAC 506

Query: 243 WEADAKKRPSFKQIISILESMSNDTSLPDK 272
           W+     RPSF +     E+M +D+S+ ++
Sbjct: 507 WKWSPADRPSFAETHQAFETMFHDSSISEE 536


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  151 bits (382), Expect = 1e-36
 Identities = 95/270 (35%), Positives = 144/270 (53%), Gaps = 17/270 (6%)

Query: 15  DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67
           D+      GGG +G VY   W      VAVK L    +++E   KEA ++  + H N++Q
Sbjct: 251 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 310

Query: 68  FYGVI-LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 126
             GV  LEPP Y IVTEY   G+L DY+     EE+    ++  AT ++  M YL  +  
Sbjct: 311 LLGVCTLEPPFY-IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK-- 367

Query: 127 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPV 183
              IHRDL +RN ++  + V+K+ DFG SR     T+ +  G  FP  W APE +     
Sbjct: 368 -NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTF 426

Query: 184 SETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQC 242
           S   D +++GV+LWE+ T  + P+ G++  QV + ++EK  R+  P  CP    EL+  C
Sbjct: 427 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YDLLEKGYRMEQPEGCPPKVYELMRAC 485

Query: 243 WEADAKKRPSFKQIISILESMSNDTSLPDK 272
           W+     RPSF +     E+M +D+S+ ++
Sbjct: 486 WKWSPADRPSFAETHQAFETMFHDSSISEE 515


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  151 bits (381), Expect = 1e-36
 Identities = 95/269 (35%), Positives = 143/269 (53%), Gaps = 17/269 (6%)

Query: 15  DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----LKIE---KEAEILSVLSHRNIIQ 67
           D+      GGG +G VY   W      VAVK L    +++E   KEA ++  + H N++Q
Sbjct: 266 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 325

Query: 68  FYGVI-LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 126
             GV  LEPP Y IVTEY   G+L DY+     EE+    ++  AT ++  M YL  +  
Sbjct: 326 LLGVCTLEPPFY-IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK-- 382

Query: 127 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPV 183
              IHRDL +RN ++  + V+K+ DFG SR     T+ +  G  FP  W APE +     
Sbjct: 383 -NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTF 441

Query: 184 SETCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQC 242
           S   D +++GV+LWE+ T  + P+ G++  QV + ++EK  R+  P  CP    EL+  C
Sbjct: 442 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV-YDLLEKGYRMEQPEGCPPKVYELMRAC 500

Query: 243 WEADAKKRPSFKQIISILESMSNDTSLPD 271
           W+     RPSF +     E+M +D+S+ +
Sbjct: 501 WKWSPADRPSFAETHQAFETMFHDSSISE 529


>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
          Length = 537

 Score =  143 bits (360), Expect = 4e-34
 Identities = 88/263 (33%), Positives = 137/263 (52%), Gaps = 17/263 (6%)

Query: 10  QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLL-------KIEKEAEILSVLSH 62
           +I  + LQ  +  G G FG V+   W    K VA+K L           +EA+I+  L H
Sbjct: 265 EIPRESLQLIKRLGNGQFGEVWMGTWNGNTK-VAIKTLKPGTMSPESFLEEAQIMKKLKH 323

Query: 63  RNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLH 122
             ++Q Y V+ E P Y IVTEY + GSL D++       + + +++  A  VA GM Y+ 
Sbjct: 324 DKLVQLYAVVSEEPIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 382

Query: 123 MEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQ 179
               +  IHRDL+S N+++    + KI DFG +R      + +  G  FP  W APE   
Sbjct: 383 R---MNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 439

Query: 180 SLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAEL 238
               +   D +S+G++L E++T+  VP+ G+   +V   V E+  R+  P  CP S  EL
Sbjct: 440 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV-ERGYRMPCPQDCPISLHEL 498

Query: 239 LHQCWEADAKKRPSFKQIISILE 261
           +  CW+ D ++RP+F+ + S LE
Sbjct: 499 MIHCWKKDPEERPTFEYLQSFLE 521


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score =  143 bits (360), Expect = 4e-34
 Identities = 91/283 (32%), Positives = 146/283 (51%), Gaps = 21/283 (7%)

Query: 10  QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEKEAEILSVLSH 62
           +I  + +Q  +  G G FG V+   W +    VAVK L           +EA+I+  L H
Sbjct: 228 EIDRNSIQLLKRLGSGQFGEVWEGLW-NNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRH 286

Query: 63  RNIIQFYGVI-LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYL 121
             +IQ Y V  LE P Y I+TE    GSL +Y+ ++   ++ +   +  A  VA GM YL
Sbjct: 287 PKLIQLYAVCTLEDPIY-IITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYL 345

Query: 122 HMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHN------HTTHMSLVGTFPWMAP 175
                   IHRDL +RNV++    + K+ DFG +R         + +   +     W AP
Sbjct: 346 ESR---NYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAP 402

Query: 176 EVIQSLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRS 234
           E I+S   S   D +S+G++L+E++T  ++P+ G+ G QV  ++ + N RL  PS+CP+ 
Sbjct: 403 EAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQ-NYRLPQPSNCPQQ 461

Query: 235 FAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFL 277
           F  ++ +CW A+ K+RP+F+ +   LE      S     N+F+
Sbjct: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFI 504


>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
          Length = 835

 Score =  141 bits (356), Expect = 1e-33
 Identities = 93/271 (34%), Positives = 139/271 (51%), Gaps = 20/271 (7%)

Query: 7   SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----------KEAE 55
           S   ++  +++F E  G GSFG VY+ +   ++K VA+K+                +E  
Sbjct: 454 SHFHLQLSEIEFHEIIGSGSFGKVYKGR--CRNKIVAIKRYRANTYCSKSDVDMFCREVS 511

Query: 56  ILSVLSHRNIIQFYGVIL-EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDV 114
           IL  L+H  +IQF G  L +P  + IVT+Y S GSL+  ++  +   +D+   +  A DV
Sbjct: 512 ILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQK-RILDLQSKLIIAVDV 570

Query: 115 AKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLV---GTFP 171
           AKGM YLH      +IHRDL S N+++  DG   + DFG SRF       ++    G   
Sbjct: 571 AKGMEYLH-NLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLR 629

Query: 172 WMAPEVI-QSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSS 230
           WMAPEV  Q    +   D +SY + LWE+LT E+PF  L+    A  +   + R  I  S
Sbjct: 630 WMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYS 689

Query: 231 CPRSFAELLHQCWEADAKKRPSFKQIISILE 261
            P+  + LL + W A  + RP F +++  LE
Sbjct: 690 IPKPISSLLIRGWNACPEGRPEFSEVVMKLE 720


>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
          Length = 936

 Score =  141 bits (356), Expect = 1e-33
 Identities = 93/271 (34%), Positives = 139/271 (51%), Gaps = 20/271 (7%)

Query: 7   SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----------KEAE 55
           S   ++  +++F E  G GSFG VY+ +   ++K VA+K+                +E  
Sbjct: 555 SHFHLQLSEIEFHEIIGSGSFGKVYKGR--CRNKIVAIKRYRANTYCSKSDVDMFCREVS 612

Query: 56  ILSVLSHRNIIQFYGVIL-EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDV 114
           IL  L+H  +IQF G  L +P  + IVT+Y S GSL+  ++  +   +D+   +  A DV
Sbjct: 613 ILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQK-RILDLQSKLIIAVDV 671

Query: 115 AKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLV---GTFP 171
           AKGM YLH      +IHRDL S N+++  DG   + DFG SRF       ++    G   
Sbjct: 672 AKGMEYLH-NLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLR 730

Query: 172 WMAPEVI-QSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSS 230
           WMAPEV  Q    +   D +SY + LWE+LT E+PF  L+    A  +   + R  I  S
Sbjct: 731 WMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYS 790

Query: 231 CPRSFAELLHQCWEADAKKRPSFKQIISILE 261
            P+  + LL + W A  + RP F +++  LE
Sbjct: 791 IPKPISSLLIRGWNACPEGRPEFSEVVMKLE 821



 Score = 29.6 bits (65), Expect = 5.9
 Identities = 18/44 (40%), Positives = 28/44 (63%), Gaps = 4/44 (9%)

Query: 271 DKCNSF---LHNKAEWRCEI-EATLERLKKLERDLSFKEQELKE 310
           DK NSF   L +  EW+ ++ E+ +  +++LE DL  KE+EL E
Sbjct: 102 DKWNSFTILLIHSDEWKKKVSESYVITIERLEDDLQIKEKELTE 145


>gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo
           sapiens]
          Length = 1038

 Score =  140 bits (353), Expect = 2e-33
 Identities = 94/273 (34%), Positives = 142/273 (52%), Gaps = 26/273 (9%)

Query: 15  DLQFFENCGGGSFGSVYRAKWISQD-KEVAVK-KLLKIE------------KEAEILSVL 60
           DL+  E  G GSFG V R +W +   K V+V  K LK +            +E   +  L
Sbjct: 125 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 184

Query: 61  SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120
            HRN+I+ YGV+L PP   +VTE A LGSL D +  ++   + +  +  +A  VA+GM Y
Sbjct: 185 DHRNLIRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAEGMGY 242

Query: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF-----HNHTTHMSLVGTFPWMAP 175
           L  +   + IHRDL +RN+++A   ++KI DFG  R       ++         F W AP
Sbjct: 243 LESK---RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 299

Query: 176 EVIQSLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRS 234
           E +++   S   DT+ +GV LWEM T  + P+ GL G Q+   + ++ ERL  P  CP+ 
Sbjct: 300 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 359

Query: 235 FAELLHQCWEADAKKRPSFKQIIS-ILESMSND 266
              ++ QCW    + RP+F  +   +LE+   D
Sbjct: 360 IYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTD 392


>gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo
           sapiens]
          Length = 1086

 Score =  140 bits (353), Expect = 2e-33
 Identities = 94/273 (34%), Positives = 142/273 (52%), Gaps = 26/273 (9%)

Query: 15  DLQFFENCGGGSFGSVYRAKWISQD-KEVAVK-KLLKIE------------KEAEILSVL 60
           DL+  E  G GSFG V R +W +   K V+V  K LK +            +E   +  L
Sbjct: 188 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 247

Query: 61  SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120
            HRN+I+ YGV+L PP   +VTE A LGSL D +  ++   + +  +  +A  VA+GM Y
Sbjct: 248 DHRNLIRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAEGMGY 305

Query: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF-----HNHTTHMSLVGTFPWMAP 175
           L  +   + IHRDL +RN+++A   ++KI DFG  R       ++         F W AP
Sbjct: 306 LESK---RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 362

Query: 176 EVIQSLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRS 234
           E +++   S   DT+ +GV LWEM T  + P+ GL G Q+   + ++ ERL  P  CP+ 
Sbjct: 363 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 422

Query: 235 FAELLHQCWEADAKKRPSFKQIIS-ILESMSND 266
              ++ QCW    + RP+F  +   +LE+   D
Sbjct: 423 IYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTD 455


>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score =  135 bits (341), Expect = 6e-32
 Identities = 86/272 (31%), Positives = 146/272 (53%), Gaps = 17/272 (6%)

Query: 3   SLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEKEAE 55
           SLG    ++K +++   +  G G FG V   KW  Q  +VAVK + +         +EA+
Sbjct: 404 SLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQ-YDVAVKMIKEGSMSEDEFFQEAQ 462

Query: 56  ILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVA 115
            +  LSH  +++FYGV  +     IVTEY S G L +Y+ S+  + ++   ++    DV 
Sbjct: 463 TMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSH-GKGLEPSQLLEMCYDVC 521

Query: 116 KGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--W 172
           +GM +L      + IHRDL +RN ++  D  +K+ DFG +R+     ++S VGT FP  W
Sbjct: 522 EGMAFLESH---QFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKW 578

Query: 173 MAPEVIQSLPVSETCDTYSYGVVLWEMLT-REVPFKGLEGLQVAWLVVEKNERLTIPSSC 231
            APEV      S   D +++G+++WE+ +  + P+   +  QV  L V +  RL  P   
Sbjct: 579 SAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVV-LKVSQGHRLYRPHLA 637

Query: 232 PRSFAELLHQCWEADAKKRPSFKQIISILESM 263
             +  ++++ CW    +KRP+F+Q++S +E +
Sbjct: 638 SDTIYQIMYSCWHELPEKRPTFQQLLSSIEPL 669


>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score =  135 bits (341), Expect = 6e-32
 Identities = 86/272 (31%), Positives = 146/272 (53%), Gaps = 17/272 (6%)

Query: 3   SLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEKEAE 55
           SLG    ++K +++   +  G G FG V   KW  Q  +VAVK + +         +EA+
Sbjct: 404 SLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQ-YDVAVKMIKEGSMSEDEFFQEAQ 462

Query: 56  ILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVA 115
            +  LSH  +++FYGV  +     IVTEY S G L +Y+ S+  + ++   ++    DV 
Sbjct: 463 TMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSH-GKGLEPSQLLEMCYDVC 521

Query: 116 KGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--W 172
           +GM +L      + IHRDL +RN ++  D  +K+ DFG +R+     ++S VGT FP  W
Sbjct: 522 EGMAFLESH---QFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKW 578

Query: 173 MAPEVIQSLPVSETCDTYSYGVVLWEMLT-REVPFKGLEGLQVAWLVVEKNERLTIPSSC 231
            APEV      S   D +++G+++WE+ +  + P+   +  QV  L V +  RL  P   
Sbjct: 579 SAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVV-LKVSQGHRLYRPHLA 637

Query: 232 PRSFAELLHQCWEADAKKRPSFKQIISILESM 263
             +  ++++ CW    +KRP+F+Q++S +E +
Sbjct: 638 SDTIYQIMYSCWHELPEKRPTFQQLLSSIEPL 669


>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
          Length = 534

 Score =  134 bits (337), Expect = 2e-31
 Identities = 84/250 (33%), Positives = 130/250 (52%), Gaps = 17/250 (6%)

Query: 23  GGGSFGSVYRAKWISQDKEVAVKKLL-------KIEKEAEILSVLSHRNIIQFYGVILEP 75
           G G F  V+   W    K VA+K L           +EA+I+  L H  ++Q Y V+ E 
Sbjct: 275 GQGCFAEVWLGTWNGNTK-VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEE 333

Query: 76  PNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLK 135
           P Y IVTEY + GSL D++       + + +++  A  VA GM Y+     +  IHRDL+
Sbjct: 334 PIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER---MNYIHRDLR 389

Query: 136 SRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPVSETCDTYSY 192
           S N+++    + KI DFG +R      + +  G  FP  W APE       +   D +S+
Sbjct: 390 SANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 449

Query: 193 GVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRP 251
           G++L E++T+  VP+ G+   +V   V E+  R+  P  CP S  EL+  CW+ D ++RP
Sbjct: 450 GILLTELVTKGRVPYPGMNNREVLEQV-ERGYRMPCPQDCPISLHELMIHCWKKDPEERP 508

Query: 252 SFKQIISILE 261
           +F+ + S LE
Sbjct: 509 TFEYLQSFLE 518


>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  132 bits (333), Expect = 5e-31
 Identities = 82/269 (30%), Positives = 137/269 (50%), Gaps = 17/269 (6%)

Query: 10  QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEKEAEILSVLSH 62
           +I  + L+     G G FG V+   W    + VA+K L           +EA+++  L H
Sbjct: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRH 322

Query: 63  RNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLH 122
             ++Q Y V+ E P Y IVTEY S GSL D++     + + +  ++  A  +A GM Y+ 
Sbjct: 323 EKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381

Query: 123 MEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQ 179
               +  +HRDL++ N+++  + V K+ DFG +R      + +  G  FP  W APE   
Sbjct: 382 R---MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438

Query: 180 SLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAEL 238
               +   D +S+G++L E+ T+  VP+ G+   +V   V E+  R+  P  CP S  +L
Sbjct: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLHDL 497

Query: 239 LHQCWEADAKKRPSFKQIISILESMSNDT 267
           + QCW  + ++RP+F+ + + LE     T
Sbjct: 498 MCQCWRKEPEERPTFEYLQAFLEDYFTST 526


>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  132 bits (333), Expect = 5e-31
 Identities = 82/269 (30%), Positives = 137/269 (50%), Gaps = 17/269 (6%)

Query: 10  QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEKEAEILSVLSH 62
           +I  + L+     G G FG V+   W    + VA+K L           +EA+++  L H
Sbjct: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRH 322

Query: 63  RNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLH 122
             ++Q Y V+ E P Y IVTEY S GSL D++     + + +  ++  A  +A GM Y+ 
Sbjct: 323 EKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381

Query: 123 MEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQ 179
               +  +HRDL++ N+++  + V K+ DFG +R      + +  G  FP  W APE   
Sbjct: 382 R---MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438

Query: 180 SLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAEL 238
               +   D +S+G++L E+ T+  VP+ G+   +V   V E+  R+  P  CP S  +L
Sbjct: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLHDL 497

Query: 239 LHQCWEADAKKRPSFKQIISILESMSNDT 267
           + QCW  + ++RP+F+ + + LE     T
Sbjct: 498 MCQCWRKEPEERPTFEYLQAFLEDYFTST 526


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.131    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,960,987
Number of Sequences: 37866
Number of extensions: 724217
Number of successful extensions: 9743
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 713
Number of HSP's successfully gapped in prelim test: 235
Number of HSP's that attempted gapping in prelim test: 5733
Number of HSP's gapped (non-prelim): 2030
length of query: 455
length of database: 18,247,518
effective HSP length: 106
effective length of query: 349
effective length of database: 14,233,722
effective search space: 4967568978
effective search space used: 4967568978
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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