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Search of human proteins with 19482158
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19482158 desert hedgehog preproprotein [Homo sapiens]
(396 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19482158 desert hedgehog preproprotein [Homo sapiens] 808 0.0
gi|119392086 Indian hedgehog homolog [Homo sapiens] 452 e-127
gi|4506939 sonic hedgehog preproprotein [Homo sapiens] 442 e-124
gi|63025196 serine arginine rich protein-specific kinase 3 [Homo... 32 1.0
gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens] 31 2.2
gi|239748690 PREDICTED: hypothetical protein [Homo sapiens] 30 5.0
gi|239742713 PREDICTED: hypothetical protein [Homo sapiens] 30 5.0
gi|239741753 PREDICTED: hypothetical protein [Homo sapiens] 30 5.0
gi|189217876 sal-like 1 isoform b [Homo sapiens] 30 5.0
gi|118442837 sal-like 1 isoform a [Homo sapiens] 30 5.0
gi|14211949 cAMP responsive element binding protein 3-like 3 [Ho... 30 5.0
gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo sap... 30 5.0
gi|126091152 cubilin [Homo sapiens] 29 8.5
gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Hom... 29 8.5
gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Hom... 29 8.5
gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sap... 29 8.5
gi|38348368 hypothetical protein LOC374872 [Homo sapiens] 29 8.5
>gi|19482158 desert hedgehog preproprotein [Homo sapiens]
Length = 396
Score = 808 bits (2088), Expect = 0.0
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MALLTNLLPLCCLALLALPAQSCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGAS 60
MALLTNLLPLCCLALLALPAQSCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGAS
Sbjct: 1 MALLTNLLPLCCLALLALPAQSCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGAS 60
Query: 61 GPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPG 120
GPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPG
Sbjct: 61 GPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPG 120
Query: 121 VRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRN 180
VRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRN
Sbjct: 121 VRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRN 180
Query: 181 HVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVL 240
HVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVL
Sbjct: 181 HVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVL 240
Query: 241 LFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSV 300
LFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSV
Sbjct: 241 LFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSV 300
Query: 301 LAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPL 360
LAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPL
Sbjct: 301 LAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPL 360
Query: 361 RLLHALGALLPGGAVQPTGMHWYSRLLYRLAEELLG 396
RLLHALGALLPGGAVQPTGMHWYSRLLYRLAEELLG
Sbjct: 361 RLLHALGALLPGGAVQPTGMHWYSRLLYRLAEELLG 396
>gi|119392086 Indian hedgehog homolog [Homo sapiens]
Length = 411
Score = 452 bits (1163), Expect = e-127
Identities = 233/389 (59%), Positives = 280/389 (71%), Gaps = 9/389 (2%)
Query: 10 LCCLALLALPAQ-SCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGASGPAEGRVA 68
L L LL +PA CGPGR VG RR ++LVPL YKQF P VPE+TLGASG EG++A
Sbjct: 14 LVLLLLLVVPAAWGCGPGR-VVGSRRRPPRKLVPLAYKQFSPNVPEKTLGASGRYEGKIA 72
Query: 69 RGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEG 128
R SERF++L PNYNPDIIFKDEEN+GADRLMT+RCK+R+N+LAI+VMN WPGV+LRVTEG
Sbjct: 73 RSSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVTEG 132
Query: 129 WDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKA 188
WDEDGHH+++SLHYEGRA+DITTSDRDRNKYGLLARLAVEAGFDWVYYES+ HVH SVK+
Sbjct: 133 WDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKS 192
Query: 189 DNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVLLFLDRDLQ 248
++S A + GGCFP A VRL SG R L + GD VLA G + VL+FLDR+
Sbjct: 193 EHSAAAKTGGCFPAGAQVRLESGARVALSAVRPGDRVLAMGEDGSPTFSDVLIFLDREPH 252
Query: 249 RRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGGDAL 308
R +F +ET+ PPR+L LTP HL+F A F FA ++ G VL G L
Sbjct: 253 RLRAFQVIETQDPPRRLALTPAHLLFTADNHTEPAARFRATFASHVQPGQYVLVAGVPGL 312
Query: 309 RPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHAL-- 366
+PARVA V+ A+G +APLT HGTL+V DV+ASC+A + H A AF PLRL H+L
Sbjct: 313 QPARVAAVSTHVALGAYAPLTKHGTLVVEDVVASCFAAVADHHLAQLAFWPLRLFHSLAW 372
Query: 367 GALLPGGAVQPTGMHWYSRLLYRLAEELL 395
G+ PG G+HWY +LLYRL LL
Sbjct: 373 GSWTPG-----EGVHWYPQLLYRLGRLLL 396
>gi|4506939 sonic hedgehog preproprotein [Homo sapiens]
Length = 462
Score = 442 bits (1138), Expect = e-124
Identities = 245/450 (54%), Positives = 299/450 (66%), Gaps = 58/450 (12%)
Query: 1 MALLTNLLPLCCLA-LLALPAQSCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGA 59
M LL L L ++ LL +CGPGRG G+RR+ +K L PL YKQF+P V E+TLGA
Sbjct: 1 MLLLARCLLLVLVSSLLVCSGLACGPGRG-FGKRRHPKK-LTPLAYKQFIPNVAEKTLGA 58
Query: 60 SGPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWP 119
SG EG+++R SERF++L PNYNPDIIFKDEEN+GADRLMT+RCK+++NALAI+VMN WP
Sbjct: 59 SGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWP 118
Query: 120 GVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESR 179
GV+LRVTEGWDEDGHH+++SLHYEGRA+DITTSDRDR+KYG+LARLAVEAGFDWVYYES+
Sbjct: 119 GVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESK 178
Query: 180 NHVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPV 239
H+H SVKA+NS+A ++GGCFPG+ATV L G K +++L GD VLAAD GR++ +
Sbjct: 179 AHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDF 238
Query: 240 LLFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAA---------------RGPAPAPG 284
L FLDRD + F +ET P +LLLT HL+F A GP P+ G
Sbjct: 239 LTFLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGP-PSGG 297
Query: 285 DFAP--VFARRLRAGDSVLA----PGGDALRPARVARVA-REEAVGVFAPLTAHGTLLVN 337
P +FA R+R G V G L PA V V EEA G +APLTA GT+L+N
Sbjct: 298 ALGPRALFASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILIN 357
Query: 338 DVLASCYAVLESHQWAHRAFAPLRLLHALGALL--------------------------- 370
VLASCYAV+E H WAHRAFAP RL HAL A L
Sbjct: 358 RVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRVALTA 417
Query: 371 PGGAVQP-----TGMHWYSRLLYRLAEELL 395
PG A P G+HWYS+LLY++ LL
Sbjct: 418 PGAADAPGAGATAGIHWYSQLLYQIGTWLL 447
>gi|63025196 serine arginine rich protein-specific kinase 3 [Homo
sapiens]
Length = 567
Score = 32.0 bits (71), Expect = 1.0
Identities = 29/96 (30%), Positives = 39/96 (40%), Gaps = 13/96 (13%)
Query: 275 AARGPAPAPGDFAPVFARRLRAGDSVLAPGGDALRPARVARVA----REEAVGVFAPLTA 330
A GP+PA AP R L AG G PA + ++ + E G+ +P T
Sbjct: 325 ARAGPSPASSSPAPGGGRSLSAGSQTSGFSGSLFSPASCSILSGSSNQRETGGLLSPSTP 384
Query: 331 HG--TLLVN-------DVLASCYAVLESHQWAHRAF 357
G LLVN D + A L + W H+ F
Sbjct: 385 FGASNLLVNPLEPQNADKIKIKIADLGNACWVHKHF 420
>gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens]
Length = 2303
Score = 30.8 bits (68), Expect = 2.2
Identities = 15/25 (60%), Positives = 16/25 (64%)
Query: 20 AQSCGPGRGPVGRRRYARKQLVPLL 44
AQSC P RGP G RR A + PLL
Sbjct: 889 AQSCSPCRGPEGGRREAGSRAHPLL 913
>gi|239748690 PREDICTED: hypothetical protein [Homo sapiens]
Length = 134
Score = 29.6 bits (65), Expect = 5.0
Identities = 22/65 (33%), Positives = 29/65 (44%), Gaps = 4/65 (6%)
Query: 9 PLCCLALLALPAQSCGPGRGPVGRRRYARKQL--VPLLYKQFVP--GVPERTLGASGPAE 64
P+ C A +A A SC G P ++ +L V LL + VP G G+SGP
Sbjct: 41 PMLCAAAIATVASSCREGLVPCAAQQLLEVKLEQVLLLPQPHVPGKGAASSPSGSSGPTC 100
Query: 65 GRVAR 69
G R
Sbjct: 101 GSCCR 105
>gi|239742713 PREDICTED: hypothetical protein [Homo sapiens]
Length = 134
Score = 29.6 bits (65), Expect = 5.0
Identities = 22/65 (33%), Positives = 29/65 (44%), Gaps = 4/65 (6%)
Query: 9 PLCCLALLALPAQSCGPGRGPVGRRRYARKQL--VPLLYKQFVP--GVPERTLGASGPAE 64
P+ C A +A A SC G P ++ +L V LL + VP G G+SGP
Sbjct: 41 PMLCAAAIATVASSCREGLVPCAAQQLLEVKLEQVLLLPQPHVPGKGAASSPSGSSGPTC 100
Query: 65 GRVAR 69
G R
Sbjct: 101 GSCCR 105
>gi|239741753 PREDICTED: hypothetical protein [Homo sapiens]
Length = 274
Score = 29.6 bits (65), Expect = 5.0
Identities = 28/82 (34%), Positives = 32/82 (39%), Gaps = 9/82 (10%)
Query: 244 DRDLQRRASFVAVETE--WPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVL 301
D+D +R S A T PPR+ L TP + P P PG P R L
Sbjct: 76 DKDQEREPSLAARGTAPPAPPRQCLPTPCPPLGHGLRPRPPPGTPPPRCPR-------TL 128
Query: 302 APGGDALRPARVARVAREEAVG 323
APG L PA AR G
Sbjct: 129 APGPRGLFPAPPPAPARTGPAG 150
>gi|189217876 sal-like 1 isoform b [Homo sapiens]
Length = 1227
Score = 29.6 bits (65), Expect = 5.0
Identities = 21/78 (26%), Positives = 34/78 (43%), Gaps = 9/78 (11%)
Query: 3 LLTNLLPLCCLALLALPAQSCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGASGP 62
++TN +P ++L+ PA C GP G L+PL+ +QF P G
Sbjct: 532 MVTNSVPTASSSVLSSPAADC----GPAGSATTFTNPLLPLMSEQFKAKFP-----FGGL 582
Query: 63 AEGRVARGSERFRDLVPN 80
+ A + + + LV N
Sbjct: 583 LDSAQASETSKLQQLVEN 600
>gi|118442837 sal-like 1 isoform a [Homo sapiens]
Length = 1324
Score = 29.6 bits (65), Expect = 5.0
Identities = 21/78 (26%), Positives = 34/78 (43%), Gaps = 9/78 (11%)
Query: 3 LLTNLLPLCCLALLALPAQSCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGASGP 62
++TN +P ++L+ PA C GP G L+PL+ +QF P G
Sbjct: 629 MVTNSVPTASSSVLSSPAADC----GPAGSATTFTNPLLPLMSEQFKAKFP-----FGGL 679
Query: 63 AEGRVARGSERFRDLVPN 80
+ A + + + LV N
Sbjct: 680 LDSAQASETSKLQQLVEN 697
>gi|14211949 cAMP responsive element binding protein 3-like 3 [Homo
sapiens]
Length = 461
Score = 29.6 bits (65), Expect = 5.0
Identities = 22/51 (43%), Positives = 27/51 (52%), Gaps = 11/51 (21%)
Query: 282 APGDFAP--VFARRLR-------AGDSVLAPGGDALRPARVARVAREEAVG 323
+PGDFAP VF+R L A D+V PG +A P A REE+ G
Sbjct: 349 SPGDFAPVRVFSRTLHNDAASRVAADAV--PGSEAPGPRPEADTTREESPG 397
>gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo
sapiens]
Length = 735
Score = 29.6 bits (65), Expect = 5.0
Identities = 23/76 (30%), Positives = 32/76 (42%), Gaps = 6/76 (7%)
Query: 262 PRKLLLTPWHLVFAARGPAPA--PGDFAPVFARRLRAGDSVLAPGG----DALRPARVAR 315
P +++ +HL + GP PA PG A L GDS P G + RP V
Sbjct: 196 PAGSVISRYHLDSSVGGPGPAAGPGGTRSPRAGYLSDGDSPERPAGPPSPTSFRPYEVGP 255
Query: 316 VAREEAVGVFAPLTAH 331
AR ++ L+ H
Sbjct: 256 AARAPPAALWGRLSLH 271
>gi|126091152 cubilin [Homo sapiens]
Length = 3623
Score = 28.9 bits (63), Expect = 8.5
Identities = 16/58 (27%), Positives = 27/58 (46%), Gaps = 7/58 (12%)
Query: 183 HVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVL 240
H+ + DN+ + +G N+ V++W+G + D L A G V P PV+
Sbjct: 2842 HLEISFDNNFLIPSGDGQCQNSFVKVWAGTEE-------VDKALLATGCGNVAPGPVI 2892
>gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Homo
sapiens]
Length = 1188
Score = 28.9 bits (63), Expect = 8.5
Identities = 24/79 (30%), Positives = 34/79 (43%), Gaps = 1/79 (1%)
Query: 28 GPVGRRRYARKQLVPLLYKQFVPGVPERTLGASGPAEGRVARG-SERFRDLVPNYNPDII 86
G G R ++ L+ L K PGVPE++LG S E A + D +P +P
Sbjct: 503 GKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPS 562
Query: 87 FKDEENSGADRLMTERCKE 105
+ N RL + KE
Sbjct: 563 VRQIRNELEARLSSAAEKE 581
>gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Homo
sapiens]
Length = 1188
Score = 28.9 bits (63), Expect = 8.5
Identities = 24/79 (30%), Positives = 34/79 (43%), Gaps = 1/79 (1%)
Query: 28 GPVGRRRYARKQLVPLLYKQFVPGVPERTLGASGPAEGRVARG-SERFRDLVPNYNPDII 86
G G R ++ L+ L K PGVPE++LG S E A + D +P +P
Sbjct: 503 GKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPS 562
Query: 87 FKDEENSGADRLMTERCKE 105
+ N RL + KE
Sbjct: 563 VRQIRNELEARLSSAAEKE 581
>gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo
sapiens]
Length = 1188
Score = 28.9 bits (63), Expect = 8.5
Identities = 24/79 (30%), Positives = 34/79 (43%), Gaps = 1/79 (1%)
Query: 28 GPVGRRRYARKQLVPLLYKQFVPGVPERTLGASGPAEGRVARG-SERFRDLVPNYNPDII 86
G G R ++ L+ L K PGVPE++LG S E A + D +P +P
Sbjct: 503 GKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPS 562
Query: 87 FKDEENSGADRLMTERCKE 105
+ N RL + KE
Sbjct: 563 VRQIRNELEARLSSAAEKE 581
>gi|38348368 hypothetical protein LOC374872 [Homo sapiens]
Length = 473
Score = 28.9 bits (63), Expect = 8.5
Identities = 18/46 (39%), Positives = 21/46 (45%)
Query: 258 TEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAP 303
T PPR LL + GP +PG AP LRA S+ AP
Sbjct: 320 TTGPPRLLLTDFGRVCLQPPGPPGSPGPHAPQLGSLLRALLSLAAP 365
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.439
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,563,697
Number of Sequences: 37866
Number of extensions: 807801
Number of successful extensions: 1876
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1860
Number of HSP's gapped (non-prelim): 22
length of query: 396
length of database: 18,247,518
effective HSP length: 104
effective length of query: 292
effective length of database: 14,309,454
effective search space: 4178360568
effective search space used: 4178360568
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.