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Search of human proteins with 194595488
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens]
(789 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens] 1603 0.0
gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens] 1554 0.0
gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens] 368 e-101
gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens] 360 4e-99
gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens] 342 1e-93
gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens] 342 1e-93
gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens] 342 1e-93
gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens] 341 1e-93
gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens] 329 5e-90
gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens] 329 5e-90
gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens] 329 5e-90
gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens] 319 7e-87
gi|170650674 phosphodiesterase 6A [Homo sapiens] 238 1e-62
gi|157364939 phosphodiesterase 6C [Homo sapiens] 238 2e-62
gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens] 232 9e-61
gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens] 232 9e-61
gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens] 223 4e-58
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 120 4e-27
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 120 4e-27
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 120 4e-27
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 119 8e-27
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 119 8e-27
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 119 8e-27
gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens] 119 8e-27
gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens] 119 8e-27
gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens] 119 8e-27
gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens] 119 8e-27
gi|48762740 phosphodiesterase 9A isoform l [Homo sapiens] 119 8e-27
gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens] 119 8e-27
gi|48762736 phosphodiesterase 9A isoform j [Homo sapiens] 119 8e-27
>gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens]
Length = 789
Score = 1603 bits (4150), Expect = 0.0
Identities = 789/789 (100%), Positives = 789/789 (100%)
Query: 1 MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRK 60
MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRK
Sbjct: 1 MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRK 60
Query: 61 NNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKAD 120
NNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKAD
Sbjct: 61 NNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKAD 120
Query: 121 GFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGD 180
GFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGD
Sbjct: 121 GFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGD 180
Query: 181 ERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWA 240
ERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWA
Sbjct: 181 ERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWA 240
Query: 241 SVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALF 300
SVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALF
Sbjct: 241 SVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALF 300
Query: 301 QVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP 360
QVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP
Sbjct: 301 QVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP 360
Query: 361 RFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCAL 420
RFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCAL
Sbjct: 361 RFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCAL 420
Query: 421 ALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIG 480
ALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIG
Sbjct: 421 ALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIG 480
Query: 481 PFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI 540
PFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI
Sbjct: 481 PFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI 540
Query: 541 LQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTV 600
LQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTV
Sbjct: 541 LQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTV 600
Query: 601 SILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQS 660
SILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQS
Sbjct: 601 SILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQS 660
Query: 661 HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKD 720
HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKD
Sbjct: 661 HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKD 720
Query: 721 EVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSV 780
EVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSV
Sbjct: 721 EVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSV 780
Query: 781 AQKAAASED 789
AQKAAASED
Sbjct: 781 AQKAAASED 789
>gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens]
Length = 779
Score = 1554 bits (4024), Expect = 0.0
Identities = 766/766 (100%), Positives = 766/766 (100%)
Query: 24 LTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQG 83
LTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQG
Sbjct: 14 LTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQG 73
Query: 84 VVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIK 143
VVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIK
Sbjct: 74 VVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIK 133
Query: 144 EGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPI 203
EGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPI
Sbjct: 134 EGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPI 193
Query: 204 VTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFL 263
VTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFL
Sbjct: 194 VTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFL 253
Query: 264 LDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGK 323
LDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGK
Sbjct: 254 LDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGK 313
Query: 324 PVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV 383
PVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV
Sbjct: 314 PVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV 373
Query: 384 SRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTME 443
SRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTME
Sbjct: 374 SRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTME 433
Query: 444 KLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCF 503
KLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCF
Sbjct: 434 KLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCF 493
Query: 504 ELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCH 563
ELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCH
Sbjct: 494 ELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCH 553
Query: 564 DLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVL 623
DLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVL
Sbjct: 554 DLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVL 613
Query: 624 EIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP 683
EIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP
Sbjct: 614 EIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP 673
Query: 684 VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQ 743
VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQ
Sbjct: 674 VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQ 733
Query: 744 ILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED 789
ILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
Sbjct: 734 ILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED 779
>gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens]
Length = 933
Score = 368 bits (944), Expect = e-101
Identities = 215/650 (33%), Positives = 356/650 (54%), Gaps = 19/650 (2%)
Query: 158 GTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELY 217
G + YV + +T+ + D D RF +G + +S+LC+PI ++ G++IG+ +
Sbjct: 283 GKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAI 342
Query: 218 RHWGKEA-FCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVA 276
+ A F ++V L + +AI Q+ K+ E + LL+V F+
Sbjct: 343 NKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTD 402
Query: 277 IDSLLEHIMIYAKNLVNADRCALFQVDH---------KNKELYSDLFDIGEEKEGKPVFK 327
++ +++ IM A+ L+ +RC++ ++ K+ EL S E K +
Sbjct: 403 LEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESME 462
Query: 328 KTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV-SRG 386
K+ + I IA VA TG +NI DAY DPRF+ E D +G+ R++LC+PI S
Sbjct: 463 KSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNH 522
Query: 387 SVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLS 446
+IGV Q++N++ G F D+ F+ F +FC L ++ MY +++ S V ++ LS
Sbjct: 523 QIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLS 582
Query: 447 YHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFE---NMWPGIFVYMVHRSCGTSCF 503
YH+ C+ E +P+ I+ HFD + + + ++M
Sbjct: 583 YHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKI 642
Query: 504 ELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACL 561
+ E LCR++++V+KNYR V YHNW+HA V M+A+L + T++E +++ CL
Sbjct: 643 DYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCL 702
Query: 562 CHDLDHRGFSNSYLQKFDHPLAALYSTS-TMEQHHFSQTVSILQLEGHNIFSTLSSSEYE 620
CHDLDHRG +N++ K LA LY TS T+E HHF+ V ILQ EGHNIF+ LSS EY
Sbjct: 703 CHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYS 762
Query: 621 QVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTK 680
++++++++I+ATDL LYF R + E+ G + N ++HRD ++MTACDL +VTK
Sbjct: 763 DLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTK 822
Query: 681 LWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYT 739
W +++ A + +EF+ +GD E +L + P + DR++KDE+P+ QL + +++ +P Y
Sbjct: 823 PWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQ 882
Query: 740 TLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED 789
L ++ +P+L + N S+WE++ + A+ SS S A A ED
Sbjct: 883 ALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASS-SPASVMVAKED 931
Score = 114 bits (284), Expect = 5e-25
Identities = 71/184 (38%), Positives = 104/184 (56%), Gaps = 14/184 (7%)
Query: 255 KQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHK---NKELYS 311
K+ F L++ K N + + SL I+I+ +V+ADRC+LF V+ K L S
Sbjct: 197 KKHNERQFFLELVKD-ISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVS 255
Query: 312 DLFDIGEEKEGKPVF-----KKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREV 366
FD+ G P+ + + E++ KGI G V GE +NIPDAY D RFN E+
Sbjct: 256 KFFDV---HAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEI 312
Query: 367 DLYTGYTTRNILCMPI-VSRGSVIGVVQMVNKI-SGSAFSKTDENNFKMFAVFCALALHC 424
D TGY T+++LCMPI S G +IGV Q +NKI G+ F++ DE +M+ FC +A+
Sbjct: 313 DKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISN 372
Query: 425 ANMY 428
A ++
Sbjct: 373 AQLF 376
Score = 32.0 bits (71), Expect = 2.3
Identities = 11/32 (34%), Positives = 21/32 (65%)
Query: 28 KVKAYLSLHPQVLDEFVSESVSAETVEKWLKR 59
+V+ +L HP++ ++++ E VEKWL+R
Sbjct: 10 EVETFLDRHPELFEDYLMRKGKQEMVEKWLQR 41
>gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens]
Length = 683
Score = 360 bits (923), Expect = 4e-99
Identities = 210/628 (33%), Positives = 346/628 (55%), Gaps = 19/628 (3%)
Query: 180 DERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEA-FCLSHQEVATANLA 238
D RF +G + +S+LC+PI ++ G++IG+ + + A F ++V L
Sbjct: 55 DRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLP 114
Query: 239 WASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCA 298
+ +AI Q+ K+ E + LL+V F+ ++ +++ IM A+ L+ +RC+
Sbjct: 115 FCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCS 174
Query: 299 LFQVDH---------KNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGE 349
+ ++ K+ EL S E K +K+ + I IA VA TG
Sbjct: 175 VLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGL 234
Query: 350 VLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV-SRGSVIGVVQMVNKISGSAFSKTDE 408
+NI DAY DPRF+ E D +G+ R++LC+PI S +IGV Q++N++ G F D+
Sbjct: 235 PVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQ 294
Query: 409 NNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRL 468
F+ F +FC L ++ MY +++ S V ++ LSYH+ C+ E +P+
Sbjct: 295 RLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVS 354
Query: 469 CKEIELFHFDIGPFE---NMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYH 525
I+ HFD + + + ++M + E LCR++++V+KNYR V YH
Sbjct: 355 ELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYH 414
Query: 526 NWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLA 583
NW+HA V M+A+L + T++E +++ CLCHDLDHRG +N++ K LA
Sbjct: 415 NWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALA 474
Query: 584 ALYSTS-TMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNR 642
LY TS T+E HHF+ V ILQ EGHNIF+ LSS EY ++++++++I+ATDL LYF R
Sbjct: 475 QLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERR 534
Query: 643 KQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD- 701
+ E+ G + N ++HRD ++MTACDL +VTK W +++ A + +EF+ +GD
Sbjct: 535 TEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDR 594
Query: 702 EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQ 761
E +L + P + DR++KDE+P+ QL + +++ +P Y L ++ +P+L + N S+
Sbjct: 595 ERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSK 654
Query: 762 WEKVIRGEETATWISSPSVAQKAAASED 789
WE++ + A+ SS S A A ED
Sbjct: 655 WEELHQKRLLASTASS-SPASVMVAKED 681
Score = 37.4 bits (85), Expect = 0.055
Identities = 28/108 (25%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 160 TVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRH 219
+++ VA + + + D D RF SG I+SVLC+PI + +IG+ ++
Sbjct: 224 SIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNR 283
Query: 220 WGKEAFCLSHQEVATANLAWASVAIHQV----QVCRGLAKQTELNDFL 263
+ F + Q + A + + + I+ QV + AKQ+ D L
Sbjct: 284 LDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVL 331
>gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens]
Length = 875
Score = 342 bits (876), Expect = 1e-93
Identities = 214/634 (33%), Positives = 330/634 (52%), Gaps = 25/634 (3%)
Query: 161 VSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELY--R 218
+ +VA + L ++D D RF +G + QS+LC+PI +++G+ + +
Sbjct: 229 IVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKK 288
Query: 219 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 278
F ++ A LA+ + +H Q+ + + N LLD++ F+ +++
Sbjct: 289 SGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLE 348
Query: 279 SLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFS-IE 337
+L+ I + + +C +F VD + +S +F + E+ K T+E + I
Sbjct: 349 VILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKIN 408
Query: 338 KGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTT----RNILCMPIVS--RGSVIGV 391
A V T E LNIPD D RF + TG R++LC PI + + VIGV
Sbjct: 409 YMYAQYVKNTMEPLNIPDVSKDKRFPWTTE-NTGNVNQQCIRSLLCTPIKNGKKNKVIGV 467
Query: 392 VQMVNKISGSA-----FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLS 446
Q+VNK+ + F++ DE + F +FC L + MY + + VT+E LS
Sbjct: 468 CQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLS 527
Query: 447 YHSICTSEEW---QGLMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGT 500
YH+ EE Q L +P +I F F ++ E I ++
Sbjct: 528 YHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQN 587
Query: 501 SCFELEKLCRFIMSVKKNYRR-VPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLL 557
+ E LCR+I+SVKKNYR+ V YHNW+HA A CM+A L+ TDLE LL
Sbjct: 588 FQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALL 647
Query: 558 IACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSS 617
IA L HDLDHRG +NSY+Q+ +HPLA LY S ME HHF Q + IL G+ I S LS
Sbjct: 648 IAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIE 707
Query: 618 EYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCS 677
EY+ L+II++AI+ATDLALY R + E+ + NL + ++ + ++MTACDL +
Sbjct: 708 EYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSA 767
Query: 678 VTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIP 736
+TK WP+ + A + EF+ +GD E K+L I+P +M+R+KK+++P Q+GF +A+ +
Sbjct: 768 ITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQ 827
Query: 737 CYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEE 770
Y LT + PLL CR N +W+ + +E
Sbjct: 828 LYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 861
Score = 118 bits (296), Expect = 2e-26
Identities = 70/158 (44%), Positives = 92/158 (58%), Gaps = 8/158 (5%)
Query: 277 IDSLLEHIMIYAKNLVNADRCALFQV---DHKNKELYSDLFDIGEEKEGKPVFKKTKEIR 333
+ +L I ++ L++ADR +LF V +K L S LFD+ E + V IR
Sbjct: 165 VTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNC--IR 222
Query: 334 FSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVV 392
KGI G VA GE LNI DAY DPRFN EVD TGY T++ILCMPI + R V+GV
Sbjct: 223 LEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVA 282
Query: 393 QMVNKISGS--AFSKTDENNFKMFAVFCALALHCANMY 428
Q +NK SG+ F++ DE +F + FC + LH A +Y
Sbjct: 283 QAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLY 320
>gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens]
Length = 823
Score = 342 bits (876), Expect = 1e-93
Identities = 214/634 (33%), Positives = 330/634 (52%), Gaps = 25/634 (3%)
Query: 161 VSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELY--R 218
+ +VA + L ++D D RF +G + QS+LC+PI +++G+ + +
Sbjct: 177 IVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKK 236
Query: 219 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 278
F ++ A LA+ + +H Q+ + + N LLD++ F+ +++
Sbjct: 237 SGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLE 296
Query: 279 SLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFS-IE 337
+L+ I + + +C +F VD + +S +F + E+ K T+E + I
Sbjct: 297 VILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKIN 356
Query: 338 KGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTT----RNILCMPIVS--RGSVIGV 391
A V T E LNIPD D RF + TG R++LC PI + + VIGV
Sbjct: 357 YMYAQYVKNTMEPLNIPDVSKDKRFPWTTE-NTGNVNQQCIRSLLCTPIKNGKKNKVIGV 415
Query: 392 VQMVNKISGSA-----FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLS 446
Q+VNK+ + F++ DE + F +FC L + MY + + VT+E LS
Sbjct: 416 CQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLS 475
Query: 447 YHSICTSEEW---QGLMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGT 500
YH+ EE Q L +P +I F F ++ E I ++
Sbjct: 476 YHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQN 535
Query: 501 SCFELEKLCRFIMSVKKNYRR-VPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLL 557
+ E LCR+I+SVKKNYR+ V YHNW+HA A CM+A L+ TDLE LL
Sbjct: 536 FQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALL 595
Query: 558 IACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSS 617
IA L HDLDHRG +NSY+Q+ +HPLA LY S ME HHF Q + IL G+ I S LS
Sbjct: 596 IAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIE 655
Query: 618 EYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCS 677
EY+ L+II++AI+ATDLALY R + E+ + NL + ++ + ++MTACDL +
Sbjct: 656 EYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSA 715
Query: 678 VTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIP 736
+TK WP+ + A + EF+ +GD E K+L I+P +M+R+KK+++P Q+GF +A+ +
Sbjct: 716 ITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQ 775
Query: 737 CYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEE 770
Y LT + PLL CR N +W+ + +E
Sbjct: 776 LYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 809
Score = 118 bits (296), Expect = 2e-26
Identities = 70/158 (44%), Positives = 92/158 (58%), Gaps = 8/158 (5%)
Query: 277 IDSLLEHIMIYAKNLVNADRCALFQV---DHKNKELYSDLFDIGEEKEGKPVFKKTKEIR 333
+ +L I ++ L++ADR +LF V +K L S LFD+ E + V IR
Sbjct: 113 VTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNC--IR 170
Query: 334 FSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVV 392
KGI G VA GE LNI DAY DPRFN EVD TGY T++ILCMPI + R V+GV
Sbjct: 171 LEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVA 230
Query: 393 QMVNKISGS--AFSKTDENNFKMFAVFCALALHCANMY 428
Q +NK SG+ F++ DE +F + FC + LH A +Y
Sbjct: 231 QAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLY 268
>gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens]
Length = 833
Score = 342 bits (876), Expect = 1e-93
Identities = 214/634 (33%), Positives = 330/634 (52%), Gaps = 25/634 (3%)
Query: 161 VSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELY--R 218
+ +VA + L ++D D RF +G + QS+LC+PI +++G+ + +
Sbjct: 187 IVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKK 246
Query: 219 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 278
F ++ A LA+ + +H Q+ + + N LLD++ F+ +++
Sbjct: 247 SGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLE 306
Query: 279 SLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFS-IE 337
+L+ I + + +C +F VD + +S +F + E+ K T+E + I
Sbjct: 307 VILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKIN 366
Query: 338 KGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTT----RNILCMPIVS--RGSVIGV 391
A V T E LNIPD D RF + TG R++LC PI + + VIGV
Sbjct: 367 YMYAQYVKNTMEPLNIPDVSKDKRFPWTTE-NTGNVNQQCIRSLLCTPIKNGKKNKVIGV 425
Query: 392 VQMVNKISGSA-----FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLS 446
Q+VNK+ + F++ DE + F +FC L + MY + + VT+E LS
Sbjct: 426 CQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLS 485
Query: 447 YHSICTSEEW---QGLMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGT 500
YH+ EE Q L +P +I F F ++ E I ++
Sbjct: 486 YHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQN 545
Query: 501 SCFELEKLCRFIMSVKKNYRR-VPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLL 557
+ E LCR+I+SVKKNYR+ V YHNW+HA A CM+A L+ TDLE LL
Sbjct: 546 FQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALL 605
Query: 558 IACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSS 617
IA L HDLDHRG +NSY+Q+ +HPLA LY S ME HHF Q + IL G+ I S LS
Sbjct: 606 IAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIE 665
Query: 618 EYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCS 677
EY+ L+II++AI+ATDLALY R + E+ + NL + ++ + ++MTACDL +
Sbjct: 666 EYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSA 725
Query: 678 VTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIP 736
+TK WP+ + A + EF+ +GD E K+L I+P +M+R+KK+++P Q+GF +A+ +
Sbjct: 726 ITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQ 785
Query: 737 CYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEE 770
Y LT + PLL CR N +W+ + +E
Sbjct: 786 LYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 819
Score = 118 bits (296), Expect = 2e-26
Identities = 70/158 (44%), Positives = 92/158 (58%), Gaps = 8/158 (5%)
Query: 277 IDSLLEHIMIYAKNLVNADRCALFQV---DHKNKELYSDLFDIGEEKEGKPVFKKTKEIR 333
+ +L I ++ L++ADR +LF V +K L S LFD+ E + V IR
Sbjct: 123 VTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNC--IR 180
Query: 334 FSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVV 392
KGI G VA GE LNI DAY DPRFN EVD TGY T++ILCMPI + R V+GV
Sbjct: 181 LEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVA 240
Query: 393 QMVNKISGS--AFSKTDENNFKMFAVFCALALHCANMY 428
Q +NK SG+ F++ DE +F + FC + LH A +Y
Sbjct: 241 QAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLY 278
>gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens]
Length = 575
Score = 341 bits (875), Expect = 1e-93
Identities = 195/570 (34%), Positives = 317/570 (55%), Gaps = 18/570 (3%)
Query: 237 LAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADR 296
L + +AI Q+ K+ E + LL+V F+ ++ +++ IM A+ L+ +R
Sbjct: 5 LPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCER 64
Query: 297 CALFQVDH---------KNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVART 347
C++ ++ K+ EL S E K +K+ + I IA VA T
Sbjct: 65 CSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVAST 124
Query: 348 GEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV-SRGSVIGVVQMVNKISGSAFSKT 406
G +NI DAY DPRF+ E D +G+ R++LC+PI S +IGV Q++N++ G F
Sbjct: 125 GLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDA 184
Query: 407 DENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPV 466
D+ F+ F +FC L ++ MY +++ S V ++ LSYH+ C+ E +P+
Sbjct: 185 DQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPL 244
Query: 467 RLCKEIELFHFDIGPFE---NMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVP 523
I+ HFD + + + ++M + E LCR++++V+KNYR V
Sbjct: 245 VSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVL 304
Query: 524 YHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHP 581
YHNW+HA V M+A+L + T++E +++ CLCHDLDHRG +N++ K
Sbjct: 305 YHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSA 364
Query: 582 LAALYSTS-TMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFG 640
LA LY TS T+E HHF+ V ILQ EGHNIF+ LSS EY ++++++++I+ATDL LYF
Sbjct: 365 LAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFE 424
Query: 641 NRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEG 700
R + E+ G + N ++HRD ++MTACDL +VTK W +++ A + +EF+ +G
Sbjct: 425 RRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQG 484
Query: 701 D-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNL 759
D E +L + P + DR++KDE+P+ QL + +++ +P Y L ++ +P+L + N
Sbjct: 485 DRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNR 544
Query: 760 SQWEKVIRGEETATWISSPSVAQKAAASED 789
S+WE++ + A+ SS S A A ED
Sbjct: 545 SKWEELHQKRLLASTASS-SPASVMVAKED 573
Score = 37.4 bits (85), Expect = 0.055
Identities = 28/108 (25%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 160 TVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRH 219
+++ VA + + + D D RF SG I+SVLC+PI + +IG+ ++
Sbjct: 116 SIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNR 175
Query: 220 WGKEAFCLSHQEVATANLAWASVAIHQV----QVCRGLAKQTELNDFL 263
+ F + Q + A + + + I+ QV + AKQ+ D L
Sbjct: 176 LDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVL 223
>gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens]
Length = 932
Score = 329 bits (844), Expect = 5e-90
Identities = 208/622 (33%), Positives = 330/622 (53%), Gaps = 43/622 (6%)
Query: 165 VAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGD-LIGILELYRHWGKE 223
V + +K++ ++D+ ++ + L G +Q++LC+P+++ D ++ + + +
Sbjct: 290 VVEDKKSIQLKDLTSEDVQQLQSML--GCELQAMLCVPVISRATDQVVALACAFNKLEGD 347
Query: 224 AFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEH 283
F + V + S + + K LL V+K F ++ + LL+
Sbjct: 348 LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQE 407
Query: 284 IMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQ 343
I+ A+NL NA+ C++F +D EL + +FD G V ++ EIR ++GIAG
Sbjct: 408 IITEARNLSNAEICSVFLLDQN--ELVAKVFD------GGVVDDESYEIRIPADQGIAGH 459
Query: 344 VARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRG-SVIGVVQMVNKISGSA 402
VA TG++LNIPDAYA P F R VD TG+ TRNILC PI + VIGV ++VNKI+G
Sbjct: 460 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 519
Query: 403 FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM-- 460
FSK DE+ F+++C +++ + +Y ++ ++ + E + YH + +E+ L+
Sbjct: 520 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 579
Query: 461 -------------QFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEK 507
FT R E + + ++M F+ C T
Sbjct: 580 GIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDM---NFINNYKIDCPT------- 629
Query: 508 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNH--TLFTDLERKGLLIACLCHDL 565
L RF + VKK YR PYHNW HA +V+H Y + +N D+E L I+C+CHDL
Sbjct: 630 LARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDL 689
Query: 566 DHRGFSNSYLQKFDHPLAALYST--STMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVL 623
DHRG +NS+ LAALYS+ S ME+HHF+Q ++IL G NIF S +Y+++L
Sbjct: 690 DHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRML 749
Query: 624 EIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP 683
+++R I+ATDLA + K L++M + G + NN+ H ++ L+MT+CDL TK W
Sbjct: 750 DLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWK 808
Query: 684 VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQ 743
T+ A IY EF+++GD K +G +P+ MMDR+K +P+ Q+ F +A+P Y L
Sbjct: 809 TTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQD 867
Query: 744 ILPPTEPLLKACRDNLSQWEKV 765
+ P L + N W KV
Sbjct: 868 LFPKAAELYERVASNREHWTKV 889
Score = 40.0 bits (92), Expect = 0.008
Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 2/91 (2%)
Query: 154 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 213
P QG ++ +VA + + L + D F RG +G R +++LC PI ++IG+
Sbjct: 451 PADQG--IAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGV 508
Query: 214 LELYRHWGKEAFCLSHQEVATANLAWASVAI 244
EL F +++ATA + ++I
Sbjct: 509 AELVNKINGPWFSKFDEDLATAFSIYCGISI 539
>gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens]
Length = 934
Score = 329 bits (844), Expect = 5e-90
Identities = 208/622 (33%), Positives = 330/622 (53%), Gaps = 43/622 (6%)
Query: 165 VAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGD-LIGILELYRHWGKE 223
V + +K++ ++D+ ++ + L G +Q++LC+P+++ D ++ + + +
Sbjct: 292 VVEDKKSIQLKDLTSEDVQQLQSML--GCELQAMLCVPVISRATDQVVALACAFNKLEGD 349
Query: 224 AFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEH 283
F + V + S + + K LL V+K F ++ + LL+
Sbjct: 350 LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQE 409
Query: 284 IMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQ 343
I+ A+NL NA+ C++F +D EL + +FD G V ++ EIR ++GIAG
Sbjct: 410 IITEARNLSNAEICSVFLLDQN--ELVAKVFD------GGVVDDESYEIRIPADQGIAGH 461
Query: 344 VARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRG-SVIGVVQMVNKISGSA 402
VA TG++LNIPDAYA P F R VD TG+ TRNILC PI + VIGV ++VNKI+G
Sbjct: 462 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 521
Query: 403 FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM-- 460
FSK DE+ F+++C +++ + +Y ++ ++ + E + YH + +E+ L+
Sbjct: 522 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 581
Query: 461 -------------QFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEK 507
FT R E + + ++M F+ C T
Sbjct: 582 GIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDM---NFINNYKIDCPT------- 631
Query: 508 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNH--TLFTDLERKGLLIACLCHDL 565
L RF + VKK YR PYHNW HA +V+H Y + +N D+E L I+C+CHDL
Sbjct: 632 LARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDL 691
Query: 566 DHRGFSNSYLQKFDHPLAALYST--STMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVL 623
DHRG +NS+ LAALYS+ S ME+HHF+Q ++IL G NIF S +Y+++L
Sbjct: 692 DHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRML 751
Query: 624 EIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP 683
+++R I+ATDLA + K L++M + G + NN+ H ++ L+MT+CDL TK W
Sbjct: 752 DLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWK 810
Query: 684 VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQ 743
T+ A IY EF+++GD K +G +P+ MMDR+K +P+ Q+ F +A+P Y L
Sbjct: 811 TTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQD 869
Query: 744 ILPPTEPLLKACRDNLSQWEKV 765
+ P L + N W KV
Sbjct: 870 LFPKAAELYERVASNREHWTKV 891
Score = 40.0 bits (92), Expect = 0.008
Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 2/91 (2%)
Query: 154 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 213
P QG ++ +VA + + L + D F RG +G R +++LC PI ++IG+
Sbjct: 453 PADQG--IAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGV 510
Query: 214 LELYRHWGKEAFCLSHQEVATANLAWASVAI 244
EL F +++ATA + ++I
Sbjct: 511 AELVNKINGPWFSKFDEDLATAFSIYCGISI 541
>gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens]
Length = 941
Score = 329 bits (844), Expect = 5e-90
Identities = 208/622 (33%), Positives = 330/622 (53%), Gaps = 43/622 (6%)
Query: 165 VAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGD-LIGILELYRHWGKE 223
V + +K++ ++D+ ++ + L G +Q++LC+P+++ D ++ + + +
Sbjct: 299 VVEDKKSIQLKDLTSEDVQQLQSML--GCELQAMLCVPVISRATDQVVALACAFNKLEGD 356
Query: 224 AFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEH 283
F + V + S + + K LL V+K F ++ + LL+
Sbjct: 357 LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQE 416
Query: 284 IMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQ 343
I+ A+NL NA+ C++F +D EL + +FD G V ++ EIR ++GIAG
Sbjct: 417 IITEARNLSNAEICSVFLLDQN--ELVAKVFD------GGVVDDESYEIRIPADQGIAGH 468
Query: 344 VARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRG-SVIGVVQMVNKISGSA 402
VA TG++LNIPDAYA P F R VD TG+ TRNILC PI + VIGV ++VNKI+G
Sbjct: 469 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 528
Query: 403 FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM-- 460
FSK DE+ F+++C +++ + +Y ++ ++ + E + YH + +E+ L+
Sbjct: 529 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 588
Query: 461 -------------QFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEK 507
FT R E + + ++M F+ C T
Sbjct: 589 GIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDM---NFINNYKIDCPT------- 638
Query: 508 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNH--TLFTDLERKGLLIACLCHDL 565
L RF + VKK YR PYHNW HA +V+H Y + +N D+E L I+C+CHDL
Sbjct: 639 LARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDL 698
Query: 566 DHRGFSNSYLQKFDHPLAALYST--STMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVL 623
DHRG +NS+ LAALYS+ S ME+HHF+Q ++IL G NIF S +Y+++L
Sbjct: 699 DHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRML 758
Query: 624 EIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP 683
+++R I+ATDLA + K L++M + G + NN+ H ++ L+MT+CDL TK W
Sbjct: 759 DLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWK 817
Query: 684 VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQ 743
T+ A IY EF+++GD K +G +P+ MMDR+K +P+ Q+ F +A+P Y L
Sbjct: 818 TTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQD 876
Query: 744 ILPPTEPLLKACRDNLSQWEKV 765
+ P L + N W KV
Sbjct: 877 LFPKAAELYERVASNREHWTKV 898
Score = 40.0 bits (92), Expect = 0.008
Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 2/91 (2%)
Query: 154 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 213
P QG ++ +VA + + L + D F RG +G R +++LC PI ++IG+
Sbjct: 460 PADQG--IAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGV 517
Query: 214 LELYRHWGKEAFCLSHQEVATANLAWASVAI 244
EL F +++ATA + ++I
Sbjct: 518 AELVNKINGPWFSKFDEDLATAFSIYCGISI 548
>gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens]
Length = 489
Score = 319 bits (817), Expect = 7e-87
Identities = 175/479 (36%), Positives = 277/479 (57%), Gaps = 9/479 (1%)
Query: 319 EKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNIL 378
E K +K+ + I IA VA TG +NI DAY DPRF+ E D +G+ R++L
Sbjct: 10 ENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVL 69
Query: 379 CMPIV-SRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECI 437
C+PI S +IGV Q++N++ G F D+ F+ F +FC L ++ MY +++ S
Sbjct: 70 CVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAK 129
Query: 438 YRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFE---NMWPGIFVYMV 494
V ++ LSYH+ C+ E +P+ I+ HFD + + + ++M
Sbjct: 130 QSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFME 189
Query: 495 HRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLE 552
+ E LCR++++V+KNYR V YHNW+HA V M+A+L + T++E
Sbjct: 190 LGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVE 249
Query: 553 RKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTS-TMEQHHFSQTVSILQLEGHNIF 611
+++ CLCHDLDHRG +N++ K LA LY TS T+E HHF+ V ILQ EGHNIF
Sbjct: 250 ILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIF 309
Query: 612 STLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMT 671
+ LSS EY ++++++++I+ATDL LYF R + E+ G + N ++HRD ++MT
Sbjct: 310 ANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMT 369
Query: 672 ACDLCSVTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFY 730
ACDL +VTK W +++ A + +EF+ +GD E +L + P + DR++KDE+P+ QL +
Sbjct: 370 ACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWI 429
Query: 731 NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED 789
+++ +P Y L ++ +P+L + N S+WE++ + A+ SS S A A ED
Sbjct: 430 DSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASS-SPASVMVAKED 487
Score = 37.4 bits (85), Expect = 0.055
Identities = 28/108 (25%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 160 TVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRH 219
+++ VA + + + D D RF SG I+SVLC+PI + +IG+ ++
Sbjct: 30 SIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNR 89
Query: 220 WGKEAFCLSHQEVATANLAWASVAIHQV----QVCRGLAKQTELNDFL 263
+ F + Q + A + + + I+ QV + AKQ+ D L
Sbjct: 90 LDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVL 137
>gi|170650674 phosphodiesterase 6A [Homo sapiens]
Length = 860
Score = 238 bits (608), Expect = 1e-62
Identities = 183/679 (26%), Positives = 302/679 (44%), Gaps = 72/679 (10%)
Query: 154 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 213
P+ G + +VA S+K V + DE F + + + +++L PI+ D++ I
Sbjct: 135 PLDMG--IVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILASPIMNG-KDVVAI 191
Query: 214 LELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDN 273
+ F +E+ L +A++ + + +T LL F+
Sbjct: 192 IMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQILLWSGSKVFEE 251
Query: 274 IVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDI---------------GE 318
+ I+ + + +N DR ++ +D ++ + D++ + G
Sbjct: 252 LTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVPPYSGPRTPDGR 311
Query: 319 E-------------KEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP--RFN 363
E KE V +++ G+ VA+ G + NI +A A+ F
Sbjct: 312 EINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIMNAPAEDFFAFQ 371
Query: 364 REVDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKISGSAFSKTDENNFKMFAVFCALAL 422
+E +G+ +N+L MPIV++ ++GV N+ G F + DE + F ++
Sbjct: 372 KEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLMESLTQFLGWSV 431
Query: 423 HCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM---------------------- 460
+ Y + E + + + YH C +EE Q ++
Sbjct: 432 LNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEIL 491
Query: 461 QFTLPVRLCKEIELFHFDIGPF---ENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKK 517
Q LP EI FHF P E + GI +Y + E L RF+ S+ K
Sbjct: 492 QAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSK 551
Query: 518 NYRRVPYHNWKHAVTVAHCMYAILQNNHT--LFTDLERKGLLIACLCHDLDHRGFSNSYL 575
YR++ YHNW+H V M+++L FTDLE ++ A CHD+DHRG +N Y
Sbjct: 552 GYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQ 611
Query: 576 QKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDL 635
K +PLA L+ +S +E+HH ++L+ E NIF L+ ++E + ++ AIIATDL
Sbjct: 612 MKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDL 671
Query: 636 ALYFGNR----------KQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVT 685
ALYF R K E + + Q+ ++ V+ +MMTACDL ++TK W V
Sbjct: 672 ALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQ 731
Query: 686 KLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 744
A + AEFW +GD E L PIPMMDR+K DE+P+ Q+GF + V Y ++
Sbjct: 732 SQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRF 791
Query: 745 LPPTEPLLKACRDNLSQWE 763
P+L +N +W+
Sbjct: 792 HEEITPMLDGITNNRKEWK 810
Score = 79.7 bits (195), Expect = 1e-14
Identities = 51/175 (29%), Positives = 93/175 (53%), Gaps = 7/175 (4%)
Query: 258 ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKN--KELYSDLFD 315
E ++ + D+ + + +N+ + + ++M L+ ADR +LF +N EL + LF+
Sbjct: 56 EESEIIFDLLRDFQENLQT-EKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFN 114
Query: 316 IGEEKEGKP-VFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTT 374
+ ++ + + +EI F ++ GI G VA + ++ N+P+ D F VD+ T Y T
Sbjct: 115 VHKDAVLEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKT 174
Query: 375 RNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYH 429
+NIL PI++ V+ ++ VNK+ GS F+K DE + F L + +YH
Sbjct: 175 KNILASPIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIM---KVYH 226
>gi|157364939 phosphodiesterase 6C [Homo sapiens]
Length = 858
Score = 238 bits (607), Expect = 2e-62
Identities = 202/830 (24%), Positives = 358/830 (43%), Gaps = 116/830 (13%)
Query: 29 VKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYEL 88
V+ YL +PQ E+ + E + + K + + E+++ +++ + EL
Sbjct: 9 VEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEES---ALCLEL 65
Query: 89 NSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPR 148
+++ GG + ++ + +AD +++ N GI E R
Sbjct: 66 LWTVQEE---GGTPEQGVHRALQRLAHLLQADRCSMFLCRSRN---------GIPEVASR 113
Query: 149 LIPAGPITQ----------------GTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESG 192
L+ P ++ + + A ++KT V D+ + F ++G
Sbjct: 114 LLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTG 173
Query: 193 TRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRG 252
+++L PIV +++ ++ F +EV + L + S+ +
Sbjct: 174 YVTKNLLATPIVVG-KEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYM 232
Query: 253 LAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDH-KNKELYS 311
++ + L+ + F+ + ++ + ++ +N +R ++ +D K KE Y
Sbjct: 233 YNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYD 292
Query: 312 DL-FDIGEEKEGK-PVFKKTKEIRF-------------------------SIEKGIAGQV 344
+ +GE + K P +E+ F ++ G+ V
Sbjct: 293 EWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYV 352
Query: 345 ARTGEVLNIPDAYADPRFNRE---VDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKISG 400
A G + N+ +A AD F + VD TG+ +N+L +PIV++ ++GV N+ G
Sbjct: 353 AENGFICNMMNAPADEYFTFQKGPVD-ETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDG 411
Query: 401 SAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM 460
F + DE + F +L + Y ++ E + E L + T EE + ++
Sbjct: 412 KPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSIL 471
Query: 461 QFTLPVRL-----CKE----------------IELFHFDIGPFENMWPGIFVYMVHRSCG 499
+F + + C+E EL+ F F G+ CG
Sbjct: 472 KFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLI------KCG 525
Query: 500 TSCF-----------ELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHT-- 546
F +E L R++ +V+K YR V YHNW+H V M+ +L
Sbjct: 526 IRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKK 585
Query: 547 LFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLE 606
+TDLE +L A CHD+DHRG +N Y K PLA L+ +S +E+HH + ++LQ E
Sbjct: 586 YYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDE 645
Query: 607 GHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLE------EMYQTGSLNLN--- 657
NIF L+ ++E V+ + AIIATDLALYF R + E QT +
Sbjct: 646 SLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVT 705
Query: 658 -NQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMD 715
+ + ++ ++ +MMTACDL ++TK W V A + EFW +GD E L QPIPMMD
Sbjct: 706 VDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMD 765
Query: 716 RDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKV 765
R+K+DE+P+ Q+GF + V Y ++ P+L ++N +W+ +
Sbjct: 766 RNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSL 815
>gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens]
Length = 853
Score = 232 bits (592), Expect = 9e-61
Identities = 211/833 (25%), Positives = 372/833 (44%), Gaps = 118/833 (14%)
Query: 23 SLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLK----------RKNNKSEDESAPKE 72
SL++E+ +++L +P ++ + +S E V + R + E+ +A E
Sbjct: 2 SLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALLE 61
Query: 73 VSR--YQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGEC 130
+ + + NM+ VV+++ + L + + + + + ++AT+
Sbjct: 62 LVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATR------------ 109
Query: 131 NNSLCIFTPPGIKEGKPRLIPAG-----PITQGTTVSAYVAKSRKTLLVEDILGDERFPR 185
L P + E L+P P+ G V +VA+++K + VED+ F
Sbjct: 110 ---LFSVQPDSVLEDC--LVPPDSEIVFPLDIG--VVGHVAQTKKMVNVEDVAECPHFSS 162
Query: 186 GTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIH 245
+ + +++L PI+ D++ ++ F ++V L +A++ +
Sbjct: 163 FADELTDYKTKNMLATPIMNG-KDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLK 221
Query: 246 QVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHK 305
+ +T LL + F+ + I+ + +N +R ++ +D
Sbjct: 222 IYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMT 281
Query: 306 NKELYSDLFDI--GEEK--------EGKP-VFKKT--------KEIR---------FSIE 337
++ + D++ + GE + +G+ VF K +EI+ +++
Sbjct: 282 KEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALA 341
Query: 338 KGIAGQVARTGEVLNIPDAYADPRFNREVDLY--TGYTTRNILCMPIVSRGS-VIGVVQM 394
G+ VA +G + NI +A AD F + +G+ +N+L MPIV++ ++GV
Sbjct: 342 SGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATF 401
Query: 395 VNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSE 454
N+ G F + DE + F ++ + Y ++ E + + + YH C +
Sbjct: 402 YNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRD 461
Query: 455 EWQGLMQFTLPVRL--------CKEIELFHFDIGPFENMWPGIF-VYMVHRS-------- 497
E +Q LP R C E EL +I E P F +Y H S
Sbjct: 462 E----IQLILPTRARLGKEPADCDEDELG--EILKEELPGPTTFDIYEFHFSDLECTELD 515
Query: 498 ---CGTSCF-EL----------EKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQN 543
CG + EL E L RF+ S+ K YRR+ YHNW+H VA M+ +L
Sbjct: 516 LVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMT 575
Query: 544 NH--TLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVS 601
+ +TDLE ++ A LCHD+DHRG +N Y K +PLA L+ +S +E+HH
Sbjct: 576 GKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKF 635
Query: 602 ILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQS- 660
+L E NI+ L+ ++E V+ ++ AIIATDLALYF R +++ + +S
Sbjct: 636 LLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSW 695
Query: 661 ---------HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQP 710
++ V+ +MMTACDL ++TK W V A + AEFW +GD E L QP
Sbjct: 696 VEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQP 755
Query: 711 IPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWE 763
IPMMDR+K E+P+ Q+GF + V Y ++ P+ ++N +W+
Sbjct: 756 IPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWK 808
>gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens]
Length = 854
Score = 232 bits (592), Expect = 9e-61
Identities = 211/833 (25%), Positives = 372/833 (44%), Gaps = 118/833 (14%)
Query: 23 SLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLK----------RKNNKSEDESAPKE 72
SL++E+ +++L +P ++ + +S E V + R + E+ +A E
Sbjct: 2 SLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALLE 61
Query: 73 VSR--YQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGEC 130
+ + + NM+ VV+++ + L + + + + + ++AT+
Sbjct: 62 LVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATR------------ 109
Query: 131 NNSLCIFTPPGIKEGKPRLIPAG-----PITQGTTVSAYVAKSRKTLLVEDILGDERFPR 185
L P + E L+P P+ G V +VA+++K + VED+ F
Sbjct: 110 ---LFSVQPDSVLEDC--LVPPDSEIVFPLDIG--VVGHVAQTKKMVNVEDVAECPHFSS 162
Query: 186 GTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIH 245
+ + +++L PI+ D++ ++ F ++V L +A++ +
Sbjct: 163 FADELTDYKTKNMLATPIMNG-KDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLK 221
Query: 246 QVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHK 305
+ +T LL + F+ + I+ + +N +R ++ +D
Sbjct: 222 IYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMT 281
Query: 306 NKELYSDLFDI--GEEK--------EGKP-VFKKT--------KEIR---------FSIE 337
++ + D++ + GE + +G+ VF K +EI+ +++
Sbjct: 282 KEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALA 341
Query: 338 KGIAGQVARTGEVLNIPDAYADPRFNREVDLY--TGYTTRNILCMPIVSRGS-VIGVVQM 394
G+ VA +G + NI +A AD F + +G+ +N+L MPIV++ ++GV
Sbjct: 342 SGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATF 401
Query: 395 VNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSE 454
N+ G F + DE + F ++ + Y ++ E + + + YH C +
Sbjct: 402 YNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRD 461
Query: 455 EWQGLMQFTLPVRL--------CKEIELFHFDIGPFENMWPGIF-VYMVHRS-------- 497
E +Q LP R C E EL +I E P F +Y H S
Sbjct: 462 E----IQLILPTRARLGKEPADCDEDELG--EILKEELPGPTTFDIYEFHFSDLECTELD 515
Query: 498 ---CGTSCF-EL----------EKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQN 543
CG + EL E L RF+ S+ K YRR+ YHNW+H VA M+ +L
Sbjct: 516 LVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMT 575
Query: 544 NH--TLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVS 601
+ +TDLE ++ A LCHD+DHRG +N Y K +PLA L+ +S +E+HH
Sbjct: 576 GKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKF 635
Query: 602 ILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQS- 660
+L E NI+ L+ ++E V+ ++ AIIATDLALYF R +++ + +S
Sbjct: 636 LLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSW 695
Query: 661 ---------HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQP 710
++ V+ +MMTACDL ++TK W V A + AEFW +GD E L QP
Sbjct: 696 VEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQP 755
Query: 711 IPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWE 763
IPMMDR+K E+P+ Q+GF + V Y ++ P+ ++N +W+
Sbjct: 756 IPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWK 808
>gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens]
Length = 575
Score = 223 bits (569), Expect = 4e-58
Identities = 155/491 (31%), Positives = 237/491 (48%), Gaps = 53/491 (10%)
Query: 320 KEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLY--TGYTTRNI 377
KE V +++ G+ VA +G + NI +A AD F + +G+ +N+
Sbjct: 45 KEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNV 104
Query: 378 LCMPIVSRGS-VIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSEC 436
L MPIV++ ++GV N+ G F + DE + F ++ + Y ++ E
Sbjct: 105 LSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLEN 164
Query: 437 IYRVTMEKLSYHSICTSEEWQGLMQFTLPVRL--------CKEIELFHFDIGPFENMWPG 488
+ + + YH C +E +Q LP R C E EL +I E P
Sbjct: 165 RKDIAQDMVLYHVKCDRDE----IQLILPTRARLGKEPADCDEDELG--EILKEELPGPT 218
Query: 489 IF-VYMVHRS-----------CGTSCF-EL----------EKLCRFIMSVKKNYRRVPYH 525
F +Y H S CG + EL E L RF+ S+ K YRR+ YH
Sbjct: 219 TFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYH 278
Query: 526 NWKHAVTVAHCMYAILQNNH--TLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLA 583
NW+H VA M+ +L + +TDLE ++ A LCHD+DHRG +N Y K +PLA
Sbjct: 279 NWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLA 338
Query: 584 ALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRK 643
L+ +S +E+HH +L E NI+ L+ ++E V+ ++ AIIATDLALYF R
Sbjct: 339 KLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRA 398
Query: 644 QLEEMYQTGSLNLNNQS----------HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIY 693
+++ + +S ++ V+ +MMTACDL ++TK W V A +
Sbjct: 399 MFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVA 458
Query: 694 AEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLL 752
AEFW +GD E L QPIPMMDR+K E+P+ Q+GF + V Y ++ P+
Sbjct: 459 AEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMF 518
Query: 753 KACRDNLSQWE 763
++N +W+
Sbjct: 519 DRLQNNRKEWK 529
Score = 30.0 bits (66), Expect = 8.7
Identities = 18/57 (31%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 163 AYVAKSRKTLLVEDILGDE--RFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELY 217
+YVA+S + + DE +F G +SG I++VL +PIV +++G+ Y
Sbjct: 67 SYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 123
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 120 bits (302), Expect = 4e-27
Identities = 81/272 (29%), Positives = 137/272 (50%), Gaps = 12/272 (4%)
Query: 506 EKLCRFIMSVKKNYR-RVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLC 562
+ L +++ ++ +Y V YHN HA VA + +L +FTDLE L A
Sbjct: 262 DTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAI 321
Query: 563 HDLDHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQ 621
HD+DH G SN +L + LA +Y+ S +E HH + +LQ E +IF LS+ +
Sbjct: 322 HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLS 381
Query: 622 VLEIIRKAIIATDLALYFGNRKQLEEMYQT------GSLNLNNQSHRDRVIGLMMTACDL 675
+ ++ ++ATD++ + L+ M +T G L L+N S R +V+ ++ DL
Sbjct: 382 LRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADL 441
Query: 676 CSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAI 735
+ TK P+ + + I AEF+ +GD ++ G+ PM D+ V + Q+GF + +A
Sbjct: 442 SNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTA-SVEKSQVGFIDYIAH 500
Query: 736 PCYTTLTQIL-PPTEPLLKACRDNLSQWEKVI 766
P + T ++ P + LL DN ++ I
Sbjct: 501 PLWETWADLVHPDAQDLLDTLEDNREWYQSKI 532
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 120 bits (302), Expect = 4e-27
Identities = 81/272 (29%), Positives = 137/272 (50%), Gaps = 12/272 (4%)
Query: 506 EKLCRFIMSVKKNYR-RVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLC 562
+ L +++ ++ +Y V YHN HA VA + +L +FTDLE L A
Sbjct: 336 DTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAI 395
Query: 563 HDLDHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQ 621
HD+DH G SN +L + LA +Y+ S +E HH + +LQ E +IF LS+ +
Sbjct: 396 HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLS 455
Query: 622 VLEIIRKAIIATDLALYFGNRKQLEEMYQT------GSLNLNNQSHRDRVIGLMMTACDL 675
+ ++ ++ATD++ + L+ M +T G L L+N S R +V+ ++ DL
Sbjct: 456 LRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADL 515
Query: 676 CSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAI 735
+ TK P+ + + I AEF+ +GD ++ G+ PM D+ V + Q+GF + +A
Sbjct: 516 SNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTA-SVEKSQVGFIDYIAH 574
Query: 736 PCYTTLTQIL-PPTEPLLKACRDNLSQWEKVI 766
P + T ++ P + LL DN ++ I
Sbjct: 575 PLWETWADLVHPDAQDLLDTLEDNREWYQSKI 606
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 120 bits (302), Expect = 4e-27
Identities = 81/272 (29%), Positives = 137/272 (50%), Gaps = 12/272 (4%)
Query: 506 EKLCRFIMSVKKNYR-RVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLC 562
+ L +++ ++ +Y V YHN HA VA + +L +FTDLE L A
Sbjct: 368 DTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAI 427
Query: 563 HDLDHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQ 621
HD+DH G SN +L + LA +Y+ S +E HH + +LQ E +IF LS+ +
Sbjct: 428 HDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLS 487
Query: 622 VLEIIRKAIIATDLALYFGNRKQLEEMYQT------GSLNLNNQSHRDRVIGLMMTACDL 675
+ ++ ++ATD++ + L+ M +T G L L+N S R +V+ ++ DL
Sbjct: 488 LRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADL 547
Query: 676 CSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAI 735
+ TK P+ + + I AEF+ +GD ++ G+ PM D+ V + Q+GF + +A
Sbjct: 548 SNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTA-SVEKSQVGFIDYIAH 606
Query: 736 PCYTTLTQIL-PPTEPLLKACRDNLSQWEKVI 766
P + T ++ P + LL DN ++ I
Sbjct: 607 PLWETWADLVHPDAQDLLDTLEDNREWYQSKI 638
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 508 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 565
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 88 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 147
Query: 566 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 624
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 148 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 207
Query: 625 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 684
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 208 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 265
Query: 685 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 744
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 266 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 324
Query: 745 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 788
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 325 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 369
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 508 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 565
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 88 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 147
Query: 566 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 624
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 148 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 207
Query: 625 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 684
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 208 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 265
Query: 685 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 744
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 266 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 324
Query: 745 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 788
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 325 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 369
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 508 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 565
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 269 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 328
Query: 566 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 624
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 329 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 388
Query: 625 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 684
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 389 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 446
Query: 685 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 744
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 447 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 505
Query: 745 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 788
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 506 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 550
>gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]
Length = 552
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 508 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 565
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 254 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 313
Query: 566 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 624
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 314 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 373
Query: 625 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 684
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 374 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 431
Query: 685 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 744
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 432 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 490
Query: 745 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 788
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 491 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 535
>gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens]
Length = 526
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 508 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 565
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 228 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 287
Query: 566 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 624
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 288 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 347
Query: 625 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 684
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 348 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 405
Query: 685 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 744
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 406 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 464
Query: 745 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 788
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 465 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 509
>gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens]
Length = 376
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 508 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 565
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 78 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 137
Query: 566 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 624
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 138 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 197
Query: 625 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 684
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 198 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 255
Query: 685 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 744
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 256 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 314
Query: 745 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 788
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 315 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 359
>gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 508 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 565
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 88 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 147
Query: 566 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 624
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 148 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 207
Query: 625 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 684
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 208 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 265
Query: 685 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 744
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 266 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 324
Query: 745 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 788
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 325 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 369
>gi|48762740 phosphodiesterase 9A isoform l [Homo sapiens]
Length = 491
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 508 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 565
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 193 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 252
Query: 566 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 624
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 253 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 312
Query: 625 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 684
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 313 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 370
Query: 685 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 744
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 371 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 429
Query: 745 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 788
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 430 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 474
>gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens]
Length = 459
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 508 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 565
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 161 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 220
Query: 566 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 624
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 221 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 280
Query: 625 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 684
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 281 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 338
Query: 685 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 744
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 339 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 397
Query: 745 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 788
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 398 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 442
>gi|48762736 phosphodiesterase 9A isoform j [Homo sapiens]
Length = 376
Score = 119 bits (299), Expect = 8e-27
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 7/285 (2%)
Query: 508 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI--LQNNHTLFTDLERKGLLIACLCHDL 565
L R++ V NYR P+HN++H VA MY++ L + F+ + L+ A +CHDL
Sbjct: 78 LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDL 137
Query: 566 DHRGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE 624
DH G++N+Y LA Y+ S +E HH + IL NIFS + ++Q+ +
Sbjct: 138 DHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQ 197
Query: 625 IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPV 684
+ I+ATD+A + +E + + + +N+ H + +++ CD+ + + V
Sbjct: 198 GMITLILATDMARHAEIMDSFKEKME--NFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 255
Query: 685 TKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 744
+ + + E++ + D K G+ P MDRDK + Q+GF V IP + T+T++
Sbjct: 256 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKA-TAQIGFIKFVLIPMFETVTKL 314
Query: 745 LPPTEP-LLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASE 788
P E +L+ ++ ++E++ R ++ + + + + A+E
Sbjct: 315 FPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATE 359
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,461,977
Number of Sequences: 37866
Number of extensions: 1302551
Number of successful extensions: 3144
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 2763
Number of HSP's gapped (non-prelim): 126
length of query: 789
length of database: 18,247,518
effective HSP length: 110
effective length of query: 679
effective length of database: 14,082,258
effective search space: 9561853182
effective search space used: 9561853182
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.