Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 194097398
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194097398 protein tyrosine phosphatase, receptor type, G
precursor [Homo sapiens]
(1445 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 2948 0.0
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 986 0.0
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 459 e-129
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 459 e-129
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 459 e-129
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 459 e-129
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 458 e-128
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 456 e-128
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 456 e-128
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 456 e-128
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 455 e-127
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 446 e-124
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 446 e-124
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 404 e-112
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 404 e-112
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 403 e-112
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 380 e-105
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 380 e-105
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor... 375 e-103
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo... 374 e-103
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 368 e-101
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 368 e-101
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 360 4e-99
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 354 4e-97
gi|110735404 protein tyrosine phosphatase, receptor type, U isof... 340 8e-93
gi|110735402 protein tyrosine phosphatase, receptor type, U isof... 340 8e-93
gi|110735406 protein tyrosine phosphatase, receptor type, U isof... 333 7e-91
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 315 3e-85
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 315 3e-85
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 315 3e-85
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 2948 bits (7643), Expect = 0.0
Identities = 1445/1445 (100%), Positives = 1445/1445 (100%)
Query: 1 MRRLLEPCWWILFLKITSSVLHYVVCFPALTEGYVGALHENRHGSAVQIRRRKASGDPYW 60
MRRLLEPCWWILFLKITSSVLHYVVCFPALTEGYVGALHENRHGSAVQIRRRKASGDPYW
Sbjct: 1 MRRLLEPCWWILFLKITSSVLHYVVCFPALTEGYVGALHENRHGSAVQIRRRKASGDPYW 60
Query: 61 AYSGAYGPEHWVTSSVSCGGRHQSPIDILDQYARVGEEYQELQLDGFDNESSNKTWMKNT 120
AYSGAYGPEHWVTSSVSCGGRHQSPIDILDQYARVGEEYQELQLDGFDNESSNKTWMKNT
Sbjct: 61 AYSGAYGPEHWVTSSVSCGGRHQSPIDILDQYARVGEEYQELQLDGFDNESSNKTWMKNT 120
Query: 121 GKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSAGSEHSINGRRFPVEMQIFFYN 180
GKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSAGSEHSINGRRFPVEMQIFFYN
Sbjct: 121 GKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSAGSEHSINGRRFPVEMQIFFYN 180
Query: 181 PDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALDPIIHGLKGVVHHEKETFLDPFVLRD 240
PDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALDPIIHGLKGVVHHEKETFLDPFVLRD
Sbjct: 181 PDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALDPIIHGLKGVVHHEKETFLDPFVLRD 240
Query: 241 LLPASLGSYYRYTGSLTTPPCSEIVEWIVFRRPVPISYHQLEAFYSIFTTEQQDHVKSVE 300
LLPASLGSYYRYTGSLTTPPCSEIVEWIVFRRPVPISYHQLEAFYSIFTTEQQDHVKSVE
Sbjct: 241 LLPASLGSYYRYTGSLTTPPCSEIVEWIVFRRPVPISYHQLEAFYSIFTTEQQDHVKSVE 300
Query: 301 YLRNNFRPQQRLHDRVVSKSAVRDSWNHDMTDFLENPLGTEASKVCSSPPIHMKVQPLNQ 360
YLRNNFRPQQRLHDRVVSKSAVRDSWNHDMTDFLENPLGTEASKVCSSPPIHMKVQPLNQ
Sbjct: 301 YLRNNFRPQQRLHDRVVSKSAVRDSWNHDMTDFLENPLGTEASKVCSSPPIHMKVQPLNQ 360
Query: 361 TALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEKTFTKDSDKDLKATISHVSPDSLYL 420
TALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEKTFTKDSDKDLKATISHVSPDSLYL
Sbjct: 361 TALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEKTFTKDSDKDLKATISHVSPDSLYL 420
Query: 421 FRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGVPTASPASSADMAPISSGSSTW 480
FRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGVPTASPASSADMAPISSGSSTW
Sbjct: 421 FRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGVPTASPASSADMAPISSGSSTW 480
Query: 481 TSSGIPFSFVSMATGMGPSSSGSQATVASVVTSTLLAGLGFGGGGISSFPSTVWPTRLPT 540
TSSGIPFSFVSMATGMGPSSSGSQATVASVVTSTLLAGLGFGGGGISSFPSTVWPTRLPT
Sbjct: 481 TSSGIPFSFVSMATGMGPSSSGSQATVASVVTSTLLAGLGFGGGGISSFPSTVWPTRLPT 540
Query: 541 AASASKQAARPVLATTEALASPGPDGDSSPTKDGEGTEEGEKDEKSESEDGEREHEEDGE 600
AASASKQAARPVLATTEALASPGPDGDSSPTKDGEGTEEGEKDEKSESEDGEREHEEDGE
Sbjct: 541 AASASKQAARPVLATTEALASPGPDGDSSPTKDGEGTEEGEKDEKSESEDGEREHEEDGE 600
Query: 601 KDSEKKEKSGVTHAAEERNQTEPSPTPSSPNRTAEGGHQTIPGHEQDHTAVPTDQTGGRR 660
KDSEKKEKSGVTHAAEERNQTEPSPTPSSPNRTAEGGHQTIPGHEQDHTAVPTDQTGGRR
Sbjct: 601 KDSEKKEKSGVTHAAEERNQTEPSPTPSSPNRTAEGGHQTIPGHEQDHTAVPTDQTGGRR 660
Query: 661 DAGPGLDPDMVTSTQVPPTATEEQYAGSDPKRPEMPSKKPMSRGDRFSEDSRFITVNPAE 720
DAGPGLDPDMVTSTQVPPTATEEQYAGSDPKRPEMPSKKPMSRGDRFSEDSRFITVNPAE
Sbjct: 661 DAGPGLDPDMVTSTQVPPTATEEQYAGSDPKRPEMPSKKPMSRGDRFSEDSRFITVNPAE 720
Query: 721 KNTSGMISRPAPGRMEWIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREV 780
KNTSGMISRPAPGRMEWIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREV
Sbjct: 721 KNTSGMISRPAPGRMEWIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREV 780
Query: 781 PSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGEL 840
PSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGEL
Sbjct: 781 PSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGEL 840
Query: 841 YSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKD 900
YSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKD
Sbjct: 841 YSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKD 900
Query: 901 SKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRK 960
SKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRK
Sbjct: 901 SKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRK 960
Query: 961 CDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQ 1020
CDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQ
Sbjct: 961 CDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQ 1020
Query: 1021 YHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQI 1080
YHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQI
Sbjct: 1021 YHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQI 1080
Query: 1081 KDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSIL 1140
KDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSIL
Sbjct: 1081 KDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSIL 1140
Query: 1141 IPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGM 1200
IPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGM
Sbjct: 1141 IPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGM 1200
Query: 1201 KGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEF 1260
KGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEF
Sbjct: 1201 KGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEF 1260
Query: 1261 VYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWP 1320
VYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWP
Sbjct: 1261 VYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWP 1320
Query: 1321 NPDAPISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVF 1380
NPDAPISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVF
Sbjct: 1321 NPDAPISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVF 1380
Query: 1381 QVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNGAVLIADESDPAES 1440
QVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNGAVLIADESDPAES
Sbjct: 1381 QVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNGAVLIADESDPAES 1440
Query: 1441 MESLV 1445
MESLV
Sbjct: 1441 MESLV 1445
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 986 bits (2548), Expect = 0.0
Identities = 527/963 (54%), Positives = 656/963 (68%), Gaps = 110/963 (11%)
Query: 551 PVLATTEALASPGPD-GDSSPTKDGEGTEEGEKDEKSESEDG-----------EREHEED 598
P AT+E S D G +DG+ ++G+ D+ DG RE +E
Sbjct: 1395 PSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIHKCMSCSSYRESQEK 1454
Query: 599 GEKDSEKKEKS----------GVTHAAEERNQT-------------EPSPTPSS------ 629
DS+ E S ++ +EE N+ P +PS+
Sbjct: 1455 VMNDSDTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDSQTGMDRSPGKSPSANGLSQK 1514
Query: 630 -----PNRTAEGGHQTIP-GHEQDHTAVPT--DQTGGRRDAGPGLDPDMVTSTQVPPTAT 681
+ G +P E AV T +++G + L+ + TST T
Sbjct: 1515 HNDGKEENDIQTGSALLPLSPESKAWAVLTSDEESGSGQGTSDSLNENE-TSTDFSFADT 1573
Query: 682 EEQ------YAGSDPKRPEMPSKKPMSRGDRFSEDSRFITVNPAEKNTSGMISRPA---- 731
E+ AG P P S SE+S V+ AE + S SR
Sbjct: 1574 NEKDADGILAAGDSEITPGFPQSPTSSVT---SENSEVFHVSEAEASNSSHESRIGLAEG 1630
Query: 732 -PGRMEWIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKG 790
+ +IPL++VSALTF+CL++L+ +L+YWR
Sbjct: 1631 LESEKKAVIPLVIVSALTFICLVVLVGILIYWR--------------------------- 1663
Query: 791 SRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSE 850
KCFQTAHFY+EDS+SPRV+ PI PI DD+ AIP+K F KH+ +L++++ GF+E
Sbjct: 1664 --KCFQTAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASS--GFTE 1719
Query: 851 DFE-------EVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKH 903
+FE EVQ CT D+ ITA+ SNHP+NKHKNRYINI+AYDHSRVKL L KD K
Sbjct: 1720 EFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKL 1779
Query: 904 SDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQ 963
+DYINANYVDGYN+ KAYIA QGPLKST EDFWRMIWE N +IVMITNLVEKGRRKCDQ
Sbjct: 1780 TDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQ 1839
Query: 964 YWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKG-QKGNPKGRQNERVVIQYH 1022
YWP + SEEYGN +VT KS ++ A YTVR F++RNTK+KKG QKG P GR VV QYH
Sbjct: 1840 YWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGR----VVTQYH 1895
Query: 1023 YTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKD 1082
YTQWPDMGVPEY+LPVLTFVR+++ A+ GPV+VHCSAGVGRTGTYIV+DSMLQQI+
Sbjct: 1896 YTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQH 1955
Query: 1083 KSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIP 1142
+ TVN+ GFLKHIR+QRNYLVQTEEQY+FIHD L+EAIL KETEV + +H+YVN++LIP
Sbjct: 1956 EGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIP 2015
Query: 1143 GVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKG 1202
G GKT+LEKQF+L++Q N + + +A K+CN+EKNR SS++P ER+RVG++ L G +G
Sbjct: 2016 GPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EG 2074
Query: 1203 TDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFVY 1262
TDYINASYIMGYY+SNEFIITQHPL HT KDFWRMIWDHNAQ++VM+PD Q++AEDEFVY
Sbjct: 2075 TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVY 2134
Query: 1263 WPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNP 1322
WP+++E +NCE+F VTL++++ CLSNEE++II DFILEATQDDYVLEVRHFQCPKWPNP
Sbjct: 2135 WPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNP 2194
Query: 1323 DAPISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQV 1382
D+PIS TFELI+VIKEEA RDGP IVHDE+G V+AG CALTTL QLE EN+VDV+QV
Sbjct: 2195 DSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQV 2254
Query: 1383 AKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNGAVLIADESDPAESME 1442
AKMINLMRPGVF DIEQYQF+YK +LSLVST++ N ++D NGA L + + AES+E
Sbjct: 2255 AKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDSNGAAL--PDGNIAESLE 2312
Query: 1443 SLV 1445
SLV
Sbjct: 2313 SLV 2315
Score = 268 bits (684), Expect = 4e-71
Identities = 143/397 (36%), Positives = 219/397 (55%), Gaps = 15/397 (3%)
Query: 50 RRRKASGDPYWAYSGAYGPEHWVTSSVSCGGRHQSPIDILDQYARVGEEYQELQLDGFDN 109
++RK + W+Y+GA ++W +C QSPI+I + +V ++L+ G+D
Sbjct: 28 QQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVNVNLKKLKFQGWDK 87
Query: 110 ESSNKTWMKNTGKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSA-GSEHSINGR 168
S T++ NTGKTV I L +DY VSG FKA K+ FHWG N S+ GSEHS+ G+
Sbjct: 88 TSLENTFIHNTGKTVEINLTNDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQ 147
Query: 169 RFPVEMQIFFYNPDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALDPIIHGLKGVVHHE 228
+FP+EMQI+ ++ D F SF+ A+ + A++I F+V +N II G++ V
Sbjct: 148 KFPLEMQIYCFDADRFSSFEEAVKGKGKLRALSILFEVGTEENLDFKAIIDGVESVSRFG 207
Query: 229 KETFLDPFVLRDLLPASLGSYYRYTGSLTTPPCSEIVEWIVFRRPVPISYHQLEAFYSIF 288
K+ LDPF+L +LLP S YY Y GSLT+PPC++ V+WIVF+ V IS QL F +
Sbjct: 208 KQAALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVSISESQLAVFCEVL 267
Query: 289 TTEQQDHVKSVEYLRNNFRPQQRLHDRVVSKSAVRDSWNHDMTDFLENPLGTEASKVCSS 348
T +Q +V ++YL+NNFR QQ R V S H+ VCSS
Sbjct: 268 TMQQSGYVMLMDYLQNNFREQQYKFSRQVFSSYTGKEEIHE--------------AVCSS 313
Query: 349 PPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEKTFTKDSDKDLKA 408
P +++ P N T+L V+W +P +Y I + + Y ED+ + F D +DL A
Sbjct: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGA 373
Query: 409 TISHVSPDSLYLFRVQAVCRNDMRSDFSQTMLFQANT 445
++++ P+ Y+ ++ A+C N + +S ++ T
Sbjct: 374 ILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPT 410
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 459 bits (1182), Expect = e-129
Identities = 264/678 (38%), Positives = 373/678 (55%), Gaps = 52/678 (7%)
Query: 743 VVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKC-FQTAHFY 801
V++ + +C+++ I + R + + P +E+PS R+ FQT
Sbjct: 1274 VLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELRRLNFQT---- 1328
Query: 802 VEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTAD 861
P + + IPI+ + D HI L +N+ FS+++E +
Sbjct: 1329 ------PGMASHPPIPILELAD------------HIERLKANDNLKFSQEYESID---PG 1367
Query: 862 MNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAY 921
T EHSN NK KNRY N++AYDHSRV L + G SDY+NANY+DGY K AY
Sbjct: 1368 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAY 1425
Query: 922 IATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLK 981
IATQG L TF DFWRMIWEQ + +VM+T L E+ R KCDQYWP+ +E +G + VTL
Sbjct: 1426 IATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL 1485
Query: 982 STKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTF 1041
T A Y VR F++ G +R V Q+ +T WPD GVPE+ P L F
Sbjct: 1486 DTVELATYCVRTFALYKN-----------GSSEKREVRQFQFTAWPDHGVPEHPTPFLAF 1534
Query: 1042 VRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNY 1101
+RR P+ GP++VHCSAGVGRTG +IVID+ML++IK + TV++ G + +R QRNY
Sbjct: 1535 LRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNY 1594
Query: 1102 LVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVG-GKTRLEKQFKLVTQC 1160
+VQTE+QYIFIHDALLEA+ TEV + L++Y+ + G T +E +FK +
Sbjct: 1595 MVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASS 1654
Query: 1161 NAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEF 1220
A SA CNK KNR +++P E RV L P+ G++G+DYINAS+I GY + +
Sbjct: 1655 KAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAY 1714
Query: 1221 IITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTL 1279
I TQ PL TT+DFWRM+W+HN+ I+VML + + ++ YWP+ E S + F V
Sbjct: 1715 IATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA-ERSARYQYFVV-- 1771
Query: 1280 ISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVI- 1336
D + N Q I+ +F + +D VR FQ WP P S + I +
Sbjct: 1772 ---DPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVH 1828
Query: 1337 -KEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFT 1395
+E +DGP VH G G+ L+ + +++ E VD+FQ KM+ RP +
Sbjct: 1829 KTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQ 1888
Query: 1396 DIEQYQFIYKAMLSLVST 1413
+QYQF Y+A L + +
Sbjct: 1889 TEDQYQFSYRAALEYLGS 1906
Score = 36.2 bits (82), Expect = 0.23
Identities = 19/58 (32%), Positives = 30/58 (51%), Gaps = 1/58 (1%)
Query: 345 VCSSPPIHMKVQPLNQTALQVSWSQP-ETIYHPPIMNYMISYSWTKNEDEKEKTFTKD 401
V S PP ++V+ +N T+++VSW P H I Y + Y +N + K + KD
Sbjct: 710 VPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKD 767
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 459 bits (1182), Expect = e-129
Identities = 264/678 (38%), Positives = 373/678 (55%), Gaps = 52/678 (7%)
Query: 743 VVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKC-FQTAHFY 801
V++ + +C+++ I + R + + P +E+PS R+ FQT
Sbjct: 1261 VLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELRRLNFQT---- 1315
Query: 802 VEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTAD 861
P + + IPI+ + D HI L +N+ FS+++E +
Sbjct: 1316 ------PGMASHPPIPILELAD------------HIERLKANDNLKFSQEYESID---PG 1354
Query: 862 MNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAY 921
T EHSN NK KNRY N++AYDHSRV L + G SDY+NANY+DGY K AY
Sbjct: 1355 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAY 1412
Query: 922 IATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLK 981
IATQG L TF DFWRMIWEQ + +VM+T L E+ R KCDQYWP+ +E +G + VTL
Sbjct: 1413 IATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL 1472
Query: 982 STKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTF 1041
T A Y VR F++ G +R V Q+ +T WPD GVPE+ P L F
Sbjct: 1473 DTVELATYCVRTFALYKN-----------GSSEKREVRQFQFTAWPDHGVPEHPTPFLAF 1521
Query: 1042 VRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNY 1101
+RR P+ GP++VHCSAGVGRTG +IVID+ML++IK + TV++ G + +R QRNY
Sbjct: 1522 LRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNY 1581
Query: 1102 LVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVG-GKTRLEKQFKLVTQC 1160
+VQTE+QYIFIHDALLEA+ TEV + L++Y+ + G T +E +FK +
Sbjct: 1582 MVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASS 1641
Query: 1161 NAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEF 1220
A SA CNK KNR +++P E RV L P+ G++G+DYINAS+I GY + +
Sbjct: 1642 KAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAY 1701
Query: 1221 IITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTL 1279
I TQ PL TT+DFWRM+W+HN+ I+VML + + ++ YWP+ E S + F V
Sbjct: 1702 IATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA-ERSARYQYFVV-- 1758
Query: 1280 ISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVI- 1336
D + N Q I+ +F + +D VR FQ WP P S + I +
Sbjct: 1759 ---DPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVH 1815
Query: 1337 -KEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFT 1395
+E +DGP VH G G+ L+ + +++ E VD+FQ KM+ RP +
Sbjct: 1816 KTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQ 1875
Query: 1396 DIEQYQFIYKAMLSLVST 1413
+QYQF Y+A L + +
Sbjct: 1876 TEDQYQFSYRAALEYLGS 1893
Score = 36.2 bits (82), Expect = 0.23
Identities = 19/58 (32%), Positives = 30/58 (51%), Gaps = 1/58 (1%)
Query: 345 VCSSPPIHMKVQPLNQTALQVSWSQP-ETIYHPPIMNYMISYSWTKNEDEKEKTFTKD 401
V S PP ++V+ +N T+++VSW P H I Y + Y +N + K + KD
Sbjct: 697 VPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKD 754
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 459 bits (1182), Expect = e-129
Identities = 264/678 (38%), Positives = 373/678 (55%), Gaps = 52/678 (7%)
Query: 743 VVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKC-FQTAHFY 801
V++ + +C+++ I + R + + P +E+PS R+ FQT
Sbjct: 1265 VLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELRRLNFQT---- 1319
Query: 802 VEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTAD 861
P + + IPI+ + D HI L +N+ FS+++E +
Sbjct: 1320 ------PGMASHPPIPILELAD------------HIERLKANDNLKFSQEYESID---PG 1358
Query: 862 MNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAY 921
T EHSN NK KNRY N++AYDHSRV L + G SDY+NANY+DGY K AY
Sbjct: 1359 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAY 1416
Query: 922 IATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLK 981
IATQG L TF DFWRMIWEQ + +VM+T L E+ R KCDQYWP+ +E +G + VTL
Sbjct: 1417 IATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL 1476
Query: 982 STKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTF 1041
T A Y VR F++ G +R V Q+ +T WPD GVPE+ P L F
Sbjct: 1477 DTVELATYCVRTFALYKN-----------GSSEKREVRQFQFTAWPDHGVPEHPTPFLAF 1525
Query: 1042 VRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNY 1101
+RR P+ GP++VHCSAGVGRTG +IVID+ML++IK + TV++ G + +R QRNY
Sbjct: 1526 LRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNY 1585
Query: 1102 LVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVG-GKTRLEKQFKLVTQC 1160
+VQTE+QYIFIHDALLEA+ TEV + L++Y+ + G T +E +FK +
Sbjct: 1586 MVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASS 1645
Query: 1161 NAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEF 1220
A SA CNK KNR +++P E RV L P+ G++G+DYINAS+I GY + +
Sbjct: 1646 KAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAY 1705
Query: 1221 IITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTL 1279
I TQ PL TT+DFWRM+W+HN+ I+VML + + ++ YWP+ E S + F V
Sbjct: 1706 IATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA-ERSARYQYFVV-- 1762
Query: 1280 ISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVI- 1336
D + N Q I+ +F + +D VR FQ WP P S + I +
Sbjct: 1763 ---DPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVH 1819
Query: 1337 -KEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFT 1395
+E +DGP VH G G+ L+ + +++ E VD+FQ KM+ RP +
Sbjct: 1820 KTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQ 1879
Query: 1396 DIEQYQFIYKAMLSLVST 1413
+QYQF Y+A L + +
Sbjct: 1880 TEDQYQFSYRAALEYLGS 1897
Score = 37.7 bits (86), Expect = 0.081
Identities = 26/86 (30%), Positives = 42/86 (48%), Gaps = 7/86 (8%)
Query: 345 VCSSPPIHMKVQPLNQTALQVSWSQP-ETIYHPPIMNYMISYSWTKNEDEKEKTFTKD-- 401
V S PP ++V+ +N T+++VSW P H I Y + Y +N + K + KD
Sbjct: 710 VPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVM 769
Query: 402 --SDKDLKATISHVSPDSLYLFRVQA 425
+D+ IS + P++ Y V A
Sbjct: 770 LADAQDM--IISGLQPETSYSLTVTA 793
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 459 bits (1182), Expect = e-129
Identities = 264/678 (38%), Positives = 373/678 (55%), Gaps = 52/678 (7%)
Query: 743 VVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKC-FQTAHFY 801
V++ + +C+++ I + R + + P +E+PS R+ FQT
Sbjct: 863 VLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELRRLNFQT---- 917
Query: 802 VEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTAD 861
P + + IPI+ + D HI L +N+ FS+++E +
Sbjct: 918 ------PGMASHPPIPILELAD------------HIERLKANDNLKFSQEYESID---PG 956
Query: 862 MNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAY 921
T EHSN NK KNRY N++AYDHSRV L + G SDY+NANY+DGY K AY
Sbjct: 957 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAY 1014
Query: 922 IATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLK 981
IATQG L TF DFWRMIWEQ + +VM+T L E+ R KCDQYWP+ +E +G + VTL
Sbjct: 1015 IATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL 1074
Query: 982 STKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTF 1041
T A Y VR F++ G +R V Q+ +T WPD GVPE+ P L F
Sbjct: 1075 DTVELATYCVRTFALYKN-----------GSSEKREVRQFQFTAWPDHGVPEHPTPFLAF 1123
Query: 1042 VRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNY 1101
+RR P+ GP++VHCSAGVGRTG +IVID+ML++IK + TV++ G + +R QRNY
Sbjct: 1124 LRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNY 1183
Query: 1102 LVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVG-GKTRLEKQFKLVTQC 1160
+VQTE+QYIFIHDALLEA+ TEV + L++Y+ + G T +E +FK +
Sbjct: 1184 MVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASS 1243
Query: 1161 NAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEF 1220
A SA CNK KNR +++P E RV L P+ G++G+DYINAS+I GY + +
Sbjct: 1244 KAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAY 1303
Query: 1221 IITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTL 1279
I TQ PL TT+DFWRM+W+HN+ I+VML + + ++ YWP+ E S + F V
Sbjct: 1304 IATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA-ERSARYQYFVV-- 1360
Query: 1280 ISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVI- 1336
D + N Q I+ +F + +D VR FQ WP P S + I +
Sbjct: 1361 ---DPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVH 1417
Query: 1337 -KEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFT 1395
+E +DGP VH G G+ L+ + +++ E VD+FQ KM+ RP +
Sbjct: 1418 KTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQ 1477
Query: 1396 DIEQYQFIYKAMLSLVST 1413
+QYQF Y+A L + +
Sbjct: 1478 TEDQYQFSYRAALEYLGS 1495
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 458 bits (1179), Expect = e-128
Identities = 249/592 (42%), Positives = 343/592 (57%), Gaps = 28/592 (4%)
Query: 828 IPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYD 887
IP+ + HI L +N+ FS+++E + T EHSN NK KNRY N++AYD
Sbjct: 927 IPILELADHIERLKANDNLKFSQEYESID---PGQQFTWEHSNLEVNKPKNRYANVIAYD 983
Query: 888 HSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGII 947
HSRV L + G SDY+NANY+DGY K AYIATQG L TF DFWRMIWEQ + +
Sbjct: 984 HSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATV 1041
Query: 948 VMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKG 1007
VM+T L E+ R KCDQYWP+ +E +G + VTL T A Y VR F++
Sbjct: 1042 VMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKN-------- 1093
Query: 1008 NPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRT 1067
G +R V Q+ +T WPD GVPE+ P L F+RR P+ GP++VHCSAGVGRT
Sbjct: 1094 ---GSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT 1150
Query: 1068 GTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEV 1127
G +IVID+ML++IK + TV++ G + +R QRNY+VQTE+QYIFIHDALLEA+ TEV
Sbjct: 1151 GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV 1210
Query: 1128 SSNQLHSYVNSILIPGVG-GKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVP 1186
+ L++Y+ + G T +E +FK + A SA CNK KNR +++P
Sbjct: 1211 PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP 1270
Query: 1187 SERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQII 1246
E RV L P+ G++G+DYINAS+I GY + +I TQ PL TT+DFWRM+W+HN+ I+
Sbjct: 1271 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV 1330
Query: 1247 VMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQD 1305
VML + + ++ YWP+ E S + F V D + N Q I+ +F + +D
Sbjct: 1331 VMLTKLREMGREKCHQYWPA-ERSARYQYFVV-----DPMAEYNMPQYILREFKVTDARD 1384
Query: 1306 DYVLEVRHFQCPKWPNPDAPISST--FELINVI--KEEALTRDGPTIVHDEYGAVSAGML 1361
VR FQ WP P S + I + +E +DGP VH G G+
Sbjct: 1385 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVF 1444
Query: 1362 CALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST 1413
L+ + +++ E VD+FQ KM+ RP + +QYQF Y+A L + +
Sbjct: 1445 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1496
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 456 bits (1173), Expect = e-128
Identities = 267/687 (38%), Positives = 378/687 (55%), Gaps = 55/687 (8%)
Query: 737 WIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCF- 795
W+I ++ A+ F+ + ++IA+L+Y + P S + + KC
Sbjct: 858 WVIGPVL--AVVFI-ICIVIAILLY----------------KNKPDSKRKDSEPRTKCLL 898
Query: 796 ---QTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDF 852
A + +D R + ++ ++ P IP+ +H L +N+ S+++
Sbjct: 899 NNADLAPHHPKDPVEMRRINFQTPGMLSHPP----IPIADMAEHTERLKANDSLKLSQEY 954
Query: 853 EEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYV 912
E + T EHSN NK KNRY N++AYDHSRV L+P+ G SDYINANYV
Sbjct: 955 ESID---PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG--IMGSDYINANYV 1009
Query: 913 DGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEE 972
DGY AYIATQGPL TF DFWRM+WEQ + IVM+T L EK R KCDQYWP +E
Sbjct: 1010 DGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTET 1069
Query: 973 YGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVP 1032
YG I VTL T A + VR FS+ G +R V Q+ +T WPD GVP
Sbjct: 1070 YGFIQVTLLDTIELATFCVRTFSLHKN-----------GSSEKREVRQFQFTAWPDHGVP 1118
Query: 1033 EYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFL 1092
EY P L F+RR P+ GP++VHCSAGVGRTG +IVID+ML++IK + TV+V G +
Sbjct: 1119 EYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHV 1178
Query: 1093 KHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVGGK-TRLE 1151
+R+QRNY+VQTE+QY FIH+ALLEA+ TEV + L++Y+ + G T +E
Sbjct: 1179 TLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGME 1238
Query: 1152 KQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYI 1211
+FK + A SA CNK KNR +++P E RV L P+ G++G+DYINAS+I
Sbjct: 1239 LEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFI 1298
Query: 1212 MGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREESM 1270
GY + +I TQ PL TT+DFWRM+W++N+ I+VML + + ++ YWP+ E S
Sbjct: 1299 DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA-ERSA 1357
Query: 1271 NCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST- 1329
+ F V D + N Q I+ +F + +D VR FQ WP P S
Sbjct: 1358 RYQYFVV-----DPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEG 1412
Query: 1330 -FELINVI--KEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMI 1386
+ I + +E +DGP VH G G+ L+ + +++ E VD+FQ KM+
Sbjct: 1413 FIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKML 1472
Query: 1387 NLMRPGVFTDIEQYQFIYKAMLSLVST 1413
RP + ++YQF Y+A L + +
Sbjct: 1473 RTQRPAMVQTEDEYQFCYQAALEYLGS 1499
Score = 34.7 bits (78), Expect = 0.68
Identities = 18/92 (19%), Positives = 41/92 (44%), Gaps = 7/92 (7%)
Query: 334 LENPLGTEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDE 393
L +P+ + + P++++ + ++T++ +SWS PP +I Y E +
Sbjct: 503 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS-------PPRQESIIKYELLFREGD 555
Query: 394 KEKTFTKDSDKDLKATISHVSPDSLYLFRVQA 425
+ + D + + P++ Y FR+ A
Sbjct: 556 HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA 587
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 456 bits (1173), Expect = e-128
Identities = 267/687 (38%), Positives = 378/687 (55%), Gaps = 55/687 (8%)
Query: 737 WIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCF- 795
W+I ++ A+ F+ + ++IA+L+Y + P S + + KC
Sbjct: 1263 WVIGPVL--AVVFI-ICIVIAILLY----------------KNKPDSKRKDSEPRTKCLL 1303
Query: 796 ---QTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDF 852
A + +D R + ++ ++ P IP+ +H L +N+ S+++
Sbjct: 1304 NNADLAPHHPKDPVEMRRINFQTPGMLSHPP----IPIADMAEHTERLKANDSLKLSQEY 1359
Query: 853 EEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYV 912
E + T EHSN NK KNRY N++AYDHSRV L+P+ G SDYINANYV
Sbjct: 1360 ESID---PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG--IMGSDYINANYV 1414
Query: 913 DGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEE 972
DGY AYIATQGPL TF DFWRM+WEQ + IVM+T L EK R KCDQYWP +E
Sbjct: 1415 DGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTET 1474
Query: 973 YGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVP 1032
YG I VTL T A + VR FS+ G +R V Q+ +T WPD GVP
Sbjct: 1475 YGFIQVTLLDTIELATFCVRTFSLHKN-----------GSSEKREVRQFQFTAWPDHGVP 1523
Query: 1033 EYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFL 1092
EY P L F+RR P+ GP++VHCSAGVGRTG +IVID+ML++IK + TV+V G +
Sbjct: 1524 EYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHV 1583
Query: 1093 KHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVGGK-TRLE 1151
+R+QRNY+VQTE+QY FIH+ALLEA+ TEV + L++Y+ + G T +E
Sbjct: 1584 TLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGME 1643
Query: 1152 KQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYI 1211
+FK + A SA CNK KNR +++P E RV L P+ G++G+DYINAS+I
Sbjct: 1644 LEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFI 1703
Query: 1212 MGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREESM 1270
GY + +I TQ PL TT+DFWRM+W++N+ I+VML + + ++ YWP+ E S
Sbjct: 1704 DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA-ERSA 1762
Query: 1271 NCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST- 1329
+ F V D + N Q I+ +F + +D VR FQ WP P S
Sbjct: 1763 RYQYFVV-----DPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEG 1817
Query: 1330 -FELINVI--KEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMI 1386
+ I + +E +DGP VH G G+ L+ + +++ E VD+FQ KM+
Sbjct: 1818 FIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKML 1877
Query: 1387 NLMRPGVFTDIEQYQFIYKAMLSLVST 1413
RP + ++YQF Y+A L + +
Sbjct: 1878 RTQRPAMVQTEDEYQFCYQAALEYLGS 1904
Score = 34.7 bits (78), Expect = 0.68
Identities = 18/92 (19%), Positives = 41/92 (44%), Gaps = 7/92 (7%)
Query: 334 LENPLGTEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDE 393
L +P+ + + P++++ + ++T++ +SWS PP +I Y E +
Sbjct: 499 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS-------PPRQESIIKYELLFREGD 551
Query: 394 KEKTFTKDSDKDLKATISHVSPDSLYLFRVQA 425
+ + D + + P++ Y FR+ A
Sbjct: 552 HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA 583
Score = 32.3 bits (72), Expect = 3.4
Identities = 23/85 (27%), Positives = 40/85 (47%), Gaps = 5/85 (5%)
Query: 345 VCSSPPIHMKVQPLNQTALQVSWSQPET-IYHPPIMNYMISYSWTKNEDEKEKTFTKD-- 401
V S+PP ++ + LN TA++V W P H I Y + Y + + + KD
Sbjct: 706 VPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVM 765
Query: 402 -SDKDLKATISHVSPDSLYLFRVQA 425
+D + I+++ P++ Y V A
Sbjct: 766 LADAQ-EMVITNLQPETAYSITVAA 789
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 456 bits (1173), Expect = e-128
Identities = 267/687 (38%), Positives = 378/687 (55%), Gaps = 55/687 (8%)
Query: 737 WIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCF- 795
W+I ++ A+ F+ + ++IA+L+Y + P S + + KC
Sbjct: 854 WVIGPVL--AVVFI-ICIVIAILLY----------------KNKPDSKRKDSEPRTKCLL 894
Query: 796 ---QTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDF 852
A + +D R + ++ ++ P IP+ +H L +N+ S+++
Sbjct: 895 NNADLAPHHPKDPVEMRRINFQTPGMLSHPP----IPIADMAEHTERLKANDSLKLSQEY 950
Query: 853 EEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYV 912
E + T EHSN NK KNRY N++AYDHSRV L+P+ G SDYINANYV
Sbjct: 951 ESID---PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG--IMGSDYINANYV 1005
Query: 913 DGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEE 972
DGY AYIATQGPL TF DFWRM+WEQ + IVM+T L EK R KCDQYWP +E
Sbjct: 1006 DGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTET 1065
Query: 973 YGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVP 1032
YG I VTL T A + VR FS+ G +R V Q+ +T WPD GVP
Sbjct: 1066 YGFIQVTLLDTIELATFCVRTFSLHKN-----------GSSEKREVRQFQFTAWPDHGVP 1114
Query: 1033 EYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFL 1092
EY P L F+RR P+ GP++VHCSAGVGRTG +IVID+ML++IK + TV+V G +
Sbjct: 1115 EYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHV 1174
Query: 1093 KHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVGGK-TRLE 1151
+R+QRNY+VQTE+QY FIH+ALLEA+ TEV + L++Y+ + G T +E
Sbjct: 1175 TLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGME 1234
Query: 1152 KQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYI 1211
+FK + A SA CNK KNR +++P E RV L P+ G++G+DYINAS+I
Sbjct: 1235 LEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFI 1294
Query: 1212 MGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREESM 1270
GY + +I TQ PL TT+DFWRM+W++N+ I+VML + + ++ YWP+ E S
Sbjct: 1295 DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA-ERSA 1353
Query: 1271 NCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST- 1329
+ F V D + N Q I+ +F + +D VR FQ WP P S
Sbjct: 1354 RYQYFVV-----DPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEG 1408
Query: 1330 -FELINVI--KEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMI 1386
+ I + +E +DGP VH G G+ L+ + +++ E VD+FQ KM+
Sbjct: 1409 FIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKML 1468
Query: 1387 NLMRPGVFTDIEQYQFIYKAMLSLVST 1413
RP + ++YQF Y+A L + +
Sbjct: 1469 RTQRPAMVQTEDEYQFCYQAALEYLGS 1495
Score = 34.7 bits (78), Expect = 0.68
Identities = 18/92 (19%), Positives = 41/92 (44%), Gaps = 7/92 (7%)
Query: 334 LENPLGTEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDE 393
L +P+ + + P++++ + ++T++ +SWS PP +I Y E +
Sbjct: 499 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS-------PPRQESIIKYELLFREGD 551
Query: 394 KEKTFTKDSDKDLKATISHVSPDSLYLFRVQA 425
+ + D + + P++ Y FR+ A
Sbjct: 552 HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA 583
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 455 bits (1171), Expect = e-127
Identities = 251/592 (42%), Positives = 342/592 (57%), Gaps = 28/592 (4%)
Query: 828 IPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYD 887
IP+ +H L +N+ S+++E + T EHSN NK KNRY N++AYD
Sbjct: 1373 IPIADMAEHTERLKANDSLKLSQEYESID---PGQQFTWEHSNLEVNKPKNRYANVIAYD 1429
Query: 888 HSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGII 947
HSRV L+P+ G SDYINANYVDGY AYIATQGPL TF DFWRM+WEQ + I
Sbjct: 1430 HSRVILQPIEG--IMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATI 1487
Query: 948 VMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKG 1007
VM+T L EK R KCDQYWP +E YG I VTL T A + VR FS+
Sbjct: 1488 VMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKN-------- 1539
Query: 1008 NPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRT 1067
G +R V Q+ +T WPD GVPEY P L F+RR P+ GP++VHCSAGVGRT
Sbjct: 1540 ---GSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRT 1596
Query: 1068 GTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEV 1127
G +IVID+ML++IK + TV+V G + +R+QRNY+VQTE+QY FIH+ALLEA+ TEV
Sbjct: 1597 GCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1656
Query: 1128 SSNQLHSYVNSILIPGVGGK-TRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVP 1186
+ L++Y+ + G T +E +FK + A SA CNK KNR +++P
Sbjct: 1657 PARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMP 1716
Query: 1187 SERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQII 1246
E RV L P+ G++G+DYINAS+I GY + +I TQ PL TT+DFWRM+W++N+ I+
Sbjct: 1717 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIV 1776
Query: 1247 VMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQD 1305
VML + + ++ YWP+ E S + F V D + N Q I+ +F + +D
Sbjct: 1777 VMLTKLREMGREKCHQYWPA-ERSARYQYFVV-----DPMAEYNMPQYILREFKVTDARD 1830
Query: 1306 DYVLEVRHFQCPKWPNPDAPISST--FELINVI--KEEALTRDGPTIVHDEYGAVSAGML 1361
VR FQ WP P S + I + +E +DGP VH G G+
Sbjct: 1831 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVF 1890
Query: 1362 CALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST 1413
L+ + +++ E VD+FQ KM+ RP + ++YQF Y+A L + +
Sbjct: 1891 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1942
Score = 34.7 bits (78), Expect = 0.68
Identities = 18/92 (19%), Positives = 41/92 (44%), Gaps = 7/92 (7%)
Query: 334 LENPLGTEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDE 393
L +P+ + + P++++ + ++T++ +SWS PP +I Y E +
Sbjct: 512 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS-------PPRQESIIKYELLFREGD 564
Query: 394 KEKTFTKDSDKDLKATISHVSPDSLYLFRVQA 425
+ + D + + P++ Y FR+ A
Sbjct: 565 HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA 596
Score = 32.0 bits (71), Expect = 4.4
Identities = 21/93 (22%), Positives = 40/93 (43%), Gaps = 12/93 (12%)
Query: 345 VCSSPPIHMKVQPLNQTALQVSWSQPET-IYHPPIMNYMISYSWTKNEDEK--------- 394
V S+PP ++ + LN TA++V W P H I Y + Y + + +
Sbjct: 719 VPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVM 778
Query: 395 --EKTFTKDSDKDLKATISHVSPDSLYLFRVQA 425
+ + D + + I+++ P++ Y V A
Sbjct: 779 LADAQWETDDTAEYEMVITNLQPETAYSITVAA 811
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 446 bits (1146), Expect = e-124
Identities = 350/1152 (30%), Positives = 526/1152 (45%), Gaps = 143/1152 (12%)
Query: 340 TEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEKTFT 399
T V P + + +N LQ W P+ + ++ Y + Y F
Sbjct: 815 TTTGAVPGRPTMMISTTAMNTALLQ--WHPPKEL-PGELLGYRLQYCRADEARPNTIDFG 871
Query: 400 KDSDKDLKATISHVSPDSLYLFRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGV 459
KD D T++ + + Y+FR+ A R + +F + + + F V TG+
Sbjct: 872 KD---DQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHV-TGL 927
Query: 460 PTASPASSADMAPISSGSSTWTSSGIPFSFVSMATGMGPSSSGSQATVASVVTST----- 514
T++ + D ++ + S + F ++ + ++ ++ T+ + T
Sbjct: 928 TTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIK 987
Query: 515 LLAGLGFGGGGIS-SFPSTVWPTRLPTAASASKQAARPVLATTEALASPGPDGDSS--PT 571
+ A G G +S S S P A + AA + T+ L+ PD S P
Sbjct: 988 VRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAA---MKTSVLLSWEVPDSYKSAVPF 1044
Query: 572 K---DGEGTEEGEKDEKSESEDGEREHEEDGEKDSEKKEKSGVTHAAEERNQTEPSPTPS 628
K +G+ E + D + E + G+ H R T P P
Sbjct: 1045 KILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIR--TAPDLLPH 1102
Query: 629 SPNRTA----EGGHQTIPGHEQDHT--------AVPTDQTGG------------------ 658
P + +G H QD + VP D+ GG
Sbjct: 1103 KPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDEL 1162
Query: 659 -------------RRDAGPGLDPDMVTSTQV-PPTAT---EEQYAG--SDPKRPEMPS-- 697
RR L P + V P T T ++ Y G + P P++
Sbjct: 1163 LEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQC 1222
Query: 698 ------KKPMSRGDRFSE---DSRFITVNPAEKNTSGMISRPAPGRMEWII-PLIVVSAL 747
K+PM + S D + V PA++ M W+ P++ V
Sbjct: 1223 FVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEP--------EMLWVTGPVLAV--- 1271
Query: 748 TFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCFQTAHFYVEDSSS 807
+ ++++IA+L+ F R+ PSS + G + AH SS
Sbjct: 1272 -ILIILIVIAILL------------FKRKRTHSPSSKDEQSIGLKDSL-LAH------SS 1311
Query: 808 PRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAE 867
V P D IP+ +I L +N+ FS+++E + T E
Sbjct: 1312 DPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESID---PGQQFTWE 1368
Query: 868 HSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGP 927
+SN NK KNRY N++AYDHSRV L + G SDYINANY+DGY K AYIATQGP
Sbjct: 1369 NSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPG--SDYINANYIDGYRKQNAYIATQGP 1426
Query: 928 LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHA 987
L T DFWRM+WEQ T +VM+T L EK R KCDQYWP +E G I VTL T A
Sbjct: 1427 LPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELA 1486
Query: 988 CYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSA 1047
YTVR F++ + G +R + Q+ + WPD GVPEY P+L F+RR A
Sbjct: 1487 TYTVRTFALHKS-----------GSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKA 1535
Query: 1048 ARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEE 1107
+ GP++VHCSAGVGRTG +IVID+ML+++K + TV++ G + +R+QRNY+VQTE+
Sbjct: 1536 CNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTED 1595
Query: 1108 QYIFIHDALLEAILGKETEVSSNQLHSYVNSI-LIPGVGGKTRLEKQFKLVTQCNAKYVE 1166
QY+FIH+ALLEA TEV + L++++ + +P T +E +FKL+ A
Sbjct: 1596 QYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSR 1655
Query: 1167 CFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHP 1226
SA CNK KNR +++P E RV L P+ G++G+DYINAS++ GY + +I TQ P
Sbjct: 1656 FISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGP 1715
Query: 1227 LPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTLISKDRL 1285
L +T+DFWRM+W+HN+ IIVML + + ++ YWP+ E S + F V D +
Sbjct: 1716 LAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA-ERSARYQYFVV-----DPM 1769
Query: 1286 CLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVI--KEEAL 1341
N Q I+ +F + +D +R FQ WP P + + I + +E
Sbjct: 1770 AEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQF 1829
Query: 1342 TRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQ 1401
+DGP VH G G+ L+ + +++ E VD+FQ K + RP + +QYQ
Sbjct: 1830 GQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQ 1889
Query: 1402 FIYKAMLSLVST 1413
Y+A L + +
Sbjct: 1890 LCYRAALEYLGS 1901
Score = 43.5 bits (101), Expect = 0.001
Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 12/93 (12%)
Query: 345 VCSSPPIHMKVQPLNQTALQVSWSQP-ETIYHPPIMNYMISYSWTKNEDEK--------- 394
V S PP ++V+PLN TA+ V W P + H I Y ++Y +N + +
Sbjct: 707 VPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVM 766
Query: 395 --EKTFTKDSDKDLKATISHVSPDSLYLFRVQA 425
E + + +D + TIS ++P++ Y V A
Sbjct: 767 LAEAQWRPEESEDYETTISGLTPETTYSVTVAA 799
Score = 35.8 bits (81), Expect = 0.31
Identities = 37/138 (26%), Positives = 59/138 (42%), Gaps = 24/138 (17%)
Query: 350 PIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEK-TFTKDSDKDLKA 408
P + + + T +Q+SW P I+ Y + Y ++ED++ K TF D
Sbjct: 515 PADFQAEVESDTRIQLSWLLPP---QERIIMYELVYWAAEDEDQQHKVTF----DPTSSY 567
Query: 409 TISHVSPDSLYLFRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGVPTASPASSA 468
T+ + PD+LY F++ A RSD + R Q T P+A P
Sbjct: 568 TLEDLKPDTLYRFQLAA------RSDMGVGVFTPTIEARTAQST-------PSAPPQK-- 612
Query: 469 DMAPISSGSSTWTSSGIP 486
+ +S GS+T S +P
Sbjct: 613 -VMCVSMGSTTVRVSWVP 629
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 446 bits (1146), Expect = e-124
Identities = 350/1152 (30%), Positives = 526/1152 (45%), Gaps = 143/1152 (12%)
Query: 340 TEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEKTFT 399
T V P + + +N LQ W P+ + ++ Y + Y F
Sbjct: 806 TTTGAVPGRPTMMISTTAMNTALLQ--WHPPKEL-PGELLGYRLQYCRADEARPNTIDFG 862
Query: 400 KDSDKDLKATISHVSPDSLYLFRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGV 459
KD D T++ + + Y+FR+ A R + +F + + + F V TG+
Sbjct: 863 KD---DQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHV-TGL 918
Query: 460 PTASPASSADMAPISSGSSTWTSSGIPFSFVSMATGMGPSSSGSQATVASVVTST----- 514
T++ + D ++ + S + F ++ + ++ ++ T+ + T
Sbjct: 919 TTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIK 978
Query: 515 LLAGLGFGGGGIS-SFPSTVWPTRLPTAASASKQAARPVLATTEALASPGPDGDSS--PT 571
+ A G G +S S S P A + AA + T+ L+ PD S P
Sbjct: 979 VRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAA---MKTSVLLSWEVPDSYKSAVPF 1035
Query: 572 K---DGEGTEEGEKDEKSESEDGEREHEEDGEKDSEKKEKSGVTHAAEERNQTEPSPTPS 628
K +G+ E + D + E + G+ H R T P P
Sbjct: 1036 KILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIR--TAPDLLPH 1093
Query: 629 SPNRTA----EGGHQTIPGHEQDHT--------AVPTDQTGG------------------ 658
P + +G H QD + VP D+ GG
Sbjct: 1094 KPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDEL 1153
Query: 659 -------------RRDAGPGLDPDMVTSTQV-PPTAT---EEQYAG--SDPKRPEMPS-- 697
RR L P + V P T T ++ Y G + P P++
Sbjct: 1154 LEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQC 1213
Query: 698 ------KKPMSRGDRFSE---DSRFITVNPAEKNTSGMISRPAPGRMEWII-PLIVVSAL 747
K+PM + S D + V PA++ M W+ P++ V
Sbjct: 1214 FVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEP--------EMLWVTGPVLAV--- 1262
Query: 748 TFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCFQTAHFYVEDSSS 807
+ ++++IA+L+ F R+ PSS + G + AH SS
Sbjct: 1263 -ILIILIVIAILL------------FKRKRTHSPSSKDEQSIGLKDSL-LAH------SS 1302
Query: 808 PRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAE 867
V P D IP+ +I L +N+ FS+++E + T E
Sbjct: 1303 DPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESID---PGQQFTWE 1359
Query: 868 HSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGP 927
+SN NK KNRY N++AYDHSRV L + G SDYINANY+DGY K AYIATQGP
Sbjct: 1360 NSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPG--SDYINANYIDGYRKQNAYIATQGP 1417
Query: 928 LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHA 987
L T DFWRM+WEQ T +VM+T L EK R KCDQYWP +E G I VTL T A
Sbjct: 1418 LPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELA 1477
Query: 988 CYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSA 1047
YTVR F++ + G +R + Q+ + WPD GVPEY P+L F+RR A
Sbjct: 1478 TYTVRTFALHKS-----------GSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKA 1526
Query: 1048 ARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEE 1107
+ GP++VHCSAGVGRTG +IVID+ML+++K + TV++ G + +R+QRNY+VQTE+
Sbjct: 1527 CNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTED 1586
Query: 1108 QYIFIHDALLEAILGKETEVSSNQLHSYVNSI-LIPGVGGKTRLEKQFKLVTQCNAKYVE 1166
QY+FIH+ALLEA TEV + L++++ + +P T +E +FKL+ A
Sbjct: 1587 QYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSR 1646
Query: 1167 CFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHP 1226
SA CNK KNR +++P E RV L P+ G++G+DYINAS++ GY + +I TQ P
Sbjct: 1647 FISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGP 1706
Query: 1227 LPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTLISKDRL 1285
L +T+DFWRM+W+HN+ IIVML + + ++ YWP+ E S + F V D +
Sbjct: 1707 LAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA-ERSARYQYFVV-----DPM 1760
Query: 1286 CLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVI--KEEAL 1341
N Q I+ +F + +D +R FQ WP P + + I + +E
Sbjct: 1761 AEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQF 1820
Query: 1342 TRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQ 1401
+DGP VH G G+ L+ + +++ E VD+FQ K + RP + +QYQ
Sbjct: 1821 GQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQ 1880
Query: 1402 FIYKAMLSLVST 1413
Y+A L + +
Sbjct: 1881 LCYRAALEYLGS 1892
Score = 40.8 bits (94), Expect = 0.010
Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 3/84 (3%)
Query: 345 VCSSPPIHMKVQPLNQTALQVSWSQP-ETIYHPPIMNYMISYSWTKNEDEKEKTFTKD-- 401
V S PP ++V+PLN TA+ V W P + H I Y ++Y +N + + +D
Sbjct: 707 VPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVM 766
Query: 402 SDKDLKATISHVSPDSLYLFRVQA 425
+ + TIS ++P++ Y V A
Sbjct: 767 LAEAQETTISGLTPETTYSVTVAA 790
Score = 35.8 bits (81), Expect = 0.31
Identities = 37/138 (26%), Positives = 59/138 (42%), Gaps = 24/138 (17%)
Query: 350 PIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEK-TFTKDSDKDLKA 408
P + + + T +Q+SW P I+ Y + Y ++ED++ K TF D
Sbjct: 515 PADFQAEVESDTRIQLSWLLPP---QERIIMYELVYWAAEDEDQQHKVTF----DPTSSY 567
Query: 409 TISHVSPDSLYLFRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGVPTASPASSA 468
T+ + PD+LY F++ A RSD + R Q T P+A P
Sbjct: 568 TLEDLKPDTLYRFQLAA------RSDMGVGVFTPTIEARTAQST-------PSAPPQK-- 612
Query: 469 DMAPISSGSSTWTSSGIP 486
+ +S GS+T S +P
Sbjct: 613 -VMCVSMGSTTVRVSWVP 629
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 404 bits (1039), Expect = e-112
Identities = 246/702 (35%), Positives = 381/702 (54%), Gaps = 54/702 (7%)
Query: 718 PAEKNTSGMISRPAPGRMEWIIPLIVVS-ALTFVCLILLIAVLVYWRGCNKIKSKGFPRR 776
P E N+S + P P+I V AL+ + +I+ I +++Y R
Sbjct: 120 PWEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIVFIIIVLYML------------R 167
Query: 777 FREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEA----IPVKQ 832
F++ +G F+ ++ ED V +S+P++ +PV +
Sbjct: 168 FKKYKQAGSHSNS-----FRLSNGRTED------VEPQSVPLLARSPSTNRKYPPLPVDK 216
Query: 833 FVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVK 892
+ I +++ F E+F + C + T E ++ ENK KNRY+NIL YDHSRV
Sbjct: 217 LEEEINRRMADDNKLFREEFNALPACP--IQATCEAASKEENKEKNRYVNILPYDHSRVH 274
Query: 893 LRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITN 952
L P+ G SDYINA++++GY + +IA QGP + T DFWRMIWEQNT IVM+TN
Sbjct: 275 LTPVEGVPD--SDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTN 332
Query: 953 LVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGR 1012
L E+ KC QYWP + YGNI V+++ + YTVR+F I+ Q G+ R
Sbjct: 333 LKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQ-------QVGDMTNR 385
Query: 1013 QNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIV 1072
+ +R++ Q+H+T WPD GVP + +L F+++ A G ++VHCSAGVGRTGT++V
Sbjct: 386 KPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVV 445
Query: 1073 IDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQL 1132
ID+ML + + V+V GF+ IR QR +VQT+ QY+FI+ ALLE L +TE+ L
Sbjct: 446 IDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSL 505
Query: 1133 HSYVNSIL--IPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERA 1190
+++ I IPG LE++FK +T + + + N +KNR ++P E
Sbjct: 506 ETHLQKIYNKIPGT-SNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFN 564
Query: 1191 RVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLP 1250
RV + G + TDY+NAS+I GY + + +I +Q PL HT +DFWRMIW+ + IVML
Sbjct: 565 RVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLT 624
Query: 1251 DNQSLAEDEFV-YWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVL 1309
+ + +++ YWPS + ++ TV L K+ C E + D ++ T+++
Sbjct: 625 ELEERGQEKCAQYWPS-DGLVSYGDITVEL-KKEEEC----ESYTVRDLLVTNTRENKSR 678
Query: 1310 EVRHFQCPKWPNPDAPISSTFELINVI----KEEALTRDGPTIVHDEYGAVSAGMLCALT 1365
++R F WP P S +I++I K++ + + P VH GA G CAL+
Sbjct: 679 QIRQFHFHGWPEVGIP-SDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALS 737
Query: 1366 TLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAM 1407
T+ ++++ E +DVFQ K + L RP + +EQY+F YK +
Sbjct: 738 TVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVV 779
Score = 195 bits (495), Expect = 3e-49
Identities = 103/298 (34%), Positives = 168/298 (56%), Gaps = 19/298 (6%)
Query: 828 IPVKQFVKHIGELYSN----NQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINI 883
+ V H+ ++Y+ + +G E+F+++ N N P N KNR + I
Sbjct: 500 LEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQ-NDKMRTGNLPANMKKNRVLQI 558
Query: 884 LAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQN 943
+ Y+ +RV + G+++ +DY+NA+++DGY + +YIA+QGPL T EDFWRMIWE
Sbjct: 559 IPYEFNRVIIPVKRGEEN--TDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWK 616
Query: 944 TGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKK 1003
+ IVM+T L E+G+ KC QYWP++ YG+I V LK + YTVR + NT+ K
Sbjct: 617 SCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENK 676
Query: 1004 GQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETG-PVLVHCSA 1062
R + Q+H+ WP++G+P +++ + + P+ VHCSA
Sbjct: 677 S-----------RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSA 725
Query: 1063 GVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI 1120
G GRTGT+ + ++L+++K + ++V +K +R QR ++VQT EQY F + + E I
Sbjct: 726 GAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI 783
Score = 113 bits (283), Expect = 1e-24
Identities = 77/264 (29%), Positives = 121/264 (45%), Gaps = 14/264 (5%)
Query: 1152 KQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYI 1211
++F + C + C +A KE NKEKNR +++P + +RV L P+ G+ +DYINAS+I
Sbjct: 234 EEFNALPACPIQ-ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFI 292
Query: 1212 MGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFV-YWPSREESM 1270
GY N+FI Q P T DFWRMIW+ N IVM+ + + E + YWP +
Sbjct: 293 NGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ---- 348
Query: 1271 NCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLE----VRHFQCPKWPNPDAPI 1326
C + +S + + + + + F ++ D + + F WP+ P
Sbjct: 349 GCWTYGNIRVSVEDVTVLVD--YTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPF 406
Query: 1327 SSTFELINVIKEEALTRD--GPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAK 1384
+ L + K +A G +VH G G + + + E VDV+
Sbjct: 407 TPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVS 466
Query: 1385 MINLMRPGVFTDIEQYQFIYKAML 1408
I R + QY FIY+A+L
Sbjct: 467 RIRAQRCQMVQTDMQYVFIYQALL 490
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 404 bits (1039), Expect = e-112
Identities = 246/702 (35%), Positives = 381/702 (54%), Gaps = 54/702 (7%)
Query: 718 PAEKNTSGMISRPAPGRMEWIIPLIVVS-ALTFVCLILLIAVLVYWRGCNKIKSKGFPRR 776
P E N+S + P P+I V AL+ + +I+ I +++Y R
Sbjct: 120 PWEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIVFIIIVLYML------------R 167
Query: 777 FREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEA----IPVKQ 832
F++ +G F+ ++ ED V +S+P++ +PV +
Sbjct: 168 FKKYKQAGSHSNS-----FRLSNGRTED------VEPQSVPLLARSPSTNRKYPPLPVDK 216
Query: 833 FVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVK 892
+ I +++ F E+F + C + T E ++ ENK KNRY+NIL YDHSRV
Sbjct: 217 LEEEINRRMADDNKLFREEFNALPACP--IQATCEAASKEENKEKNRYVNILPYDHSRVH 274
Query: 893 LRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITN 952
L P+ G SDYINA++++GY + +IA QGP + T DFWRMIWEQNT IVM+TN
Sbjct: 275 LTPVEGVPD--SDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTN 332
Query: 953 LVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGR 1012
L E+ KC QYWP + YGNI V+++ + YTVR+F I+ Q G+ R
Sbjct: 333 LKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQ-------QVGDMTNR 385
Query: 1013 QNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIV 1072
+ +R++ Q+H+T WPD GVP + +L F+++ A G ++VHCSAGVGRTGT++V
Sbjct: 386 KPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVV 445
Query: 1073 IDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQL 1132
ID+ML + + V+V GF+ IR QR +VQT+ QY+FI+ ALLE L +TE+ L
Sbjct: 446 IDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSL 505
Query: 1133 HSYVNSIL--IPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERA 1190
+++ I IPG LE++FK +T + + + N +KNR ++P E
Sbjct: 506 ETHLQKIYNKIPGT-SNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFN 564
Query: 1191 RVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLP 1250
RV + G + TDY+NAS+I GY + + +I +Q PL HT +DFWRMIW+ + IVML
Sbjct: 565 RVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLT 624
Query: 1251 DNQSLAEDEFV-YWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVL 1309
+ + +++ YWPS + ++ TV L K+ C E + D ++ T+++
Sbjct: 625 ELEERGQEKCAQYWPS-DGLVSYGDITVEL-KKEEEC----ESYTVRDLLVTNTRENKSR 678
Query: 1310 EVRHFQCPKWPNPDAPISSTFELINVI----KEEALTRDGPTIVHDEYGAVSAGMLCALT 1365
++R F WP P S +I++I K++ + + P VH GA G CAL+
Sbjct: 679 QIRQFHFHGWPEVGIP-SDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALS 737
Query: 1366 TLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAM 1407
T+ ++++ E +DVFQ K + L RP + +EQY+F YK +
Sbjct: 738 TVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVV 779
Score = 195 bits (495), Expect = 3e-49
Identities = 103/298 (34%), Positives = 168/298 (56%), Gaps = 19/298 (6%)
Query: 828 IPVKQFVKHIGELYSN----NQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINI 883
+ V H+ ++Y+ + +G E+F+++ N N P N KNR + I
Sbjct: 500 LEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQ-NDKMRTGNLPANMKKNRVLQI 558
Query: 884 LAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQN 943
+ Y+ +RV + G+++ +DY+NA+++DGY + +YIA+QGPL T EDFWRMIWE
Sbjct: 559 IPYEFNRVIIPVKRGEEN--TDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWK 616
Query: 944 TGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKK 1003
+ IVM+T L E+G+ KC QYWP++ YG+I V LK + YTVR + NT+ K
Sbjct: 617 SCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENK 676
Query: 1004 GQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETG-PVLVHCSA 1062
R + Q+H+ WP++G+P +++ + + P+ VHCSA
Sbjct: 677 S-----------RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSA 725
Query: 1063 GVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI 1120
G GRTGT+ + ++L+++K + ++V +K +R QR ++VQT EQY F + + E I
Sbjct: 726 GAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI 783
Score = 113 bits (283), Expect = 1e-24
Identities = 77/264 (29%), Positives = 121/264 (45%), Gaps = 14/264 (5%)
Query: 1152 KQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYI 1211
++F + C + C +A KE NKEKNR +++P + +RV L P+ G+ +DYINAS+I
Sbjct: 234 EEFNALPACPIQ-ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFI 292
Query: 1212 MGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFV-YWPSREESM 1270
GY N+FI Q P T DFWRMIW+ N IVM+ + + E + YWP +
Sbjct: 293 NGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ---- 348
Query: 1271 NCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLE----VRHFQCPKWPNPDAPI 1326
C + +S + + + + + F ++ D + + F WP+ P
Sbjct: 349 GCWTYGNIRVSVEDVTVLVD--YTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPF 406
Query: 1327 SSTFELINVIKEEALTRD--GPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAK 1384
+ L + K +A G +VH G G + + + E VDV+
Sbjct: 407 TPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVS 466
Query: 1385 MINLMRPGVFTDIEQYQFIYKAML 1408
I R + QY FIY+A+L
Sbjct: 467 RIRAQRCQMVQTDMQYVFIYQALL 490
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 403 bits (1035), Expect = e-112
Identities = 239/678 (35%), Positives = 373/678 (55%), Gaps = 53/678 (7%)
Query: 741 LIVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCFQTAHF 800
+ V+ AL+ + +I+ I +++Y RF++ +G F+ ++
Sbjct: 153 IAVMVALSSLLVIVFIIIVLYML------------RFKKYKQAGSHSNS-----FRLSNG 195
Query: 801 YVEDSSSPRVVPNESIPIIPIPDDMEA----IPVKQFVKHIGELYSNNQHGFSEDFEEVQ 856
ED V +S+P++ +PV + + I +++ F E+F +
Sbjct: 196 RTED------VEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALP 249
Query: 857 RCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYN 916
C + T E ++ ENK KNRY+NIL YDHSRV L P+ G SDYINA++++GY
Sbjct: 250 ACP--IQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPD--SDYINASFINGYQ 305
Query: 917 KAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNI 976
+ +IA QGP + T DFWRMIWEQNT IVM+TNL E+ KC QYWP + YGNI
Sbjct: 306 EKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNI 365
Query: 977 IVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYAL 1036
V+++ + YTVR+F I+ Q G+ R+ +R++ Q+H+T WPD GVP +
Sbjct: 366 RVSVEDVTVLVDYTVRKFCIQ-------QVGDMTNRKPQRLITQFHFTSWPDFGVPFTPI 418
Query: 1037 PVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIR 1096
+L F+++ A G ++VHCSAGVGRTGT++VID+ML + + V+V GF+ IR
Sbjct: 419 GMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIR 478
Query: 1097 TQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSIL--IPGVGGKTRLEKQF 1154
QR +VQT+ QY+FI+ ALLE L +TE+ L +++ I IPG LE++F
Sbjct: 479 AQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGT-SNNGLEEEF 537
Query: 1155 KLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGY 1214
K +T + + + N +KNR ++P E RV + G + TDY+NAS+I GY
Sbjct: 538 KKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGY 597
Query: 1215 YRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFV-YWPSREESMNCE 1273
+ + +I +Q PL HT +DFWRMIW+ + IVML + + +++ YWPS + ++
Sbjct: 598 RQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS-DGLVSYG 656
Query: 1274 AFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISSTFELI 1333
TV L K+ C E + D ++ T+++ ++R F WP P S +I
Sbjct: 657 DITVEL-KKEEEC----ESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIP-SDGKGMI 710
Query: 1334 NVI----KEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLM 1389
++I K++ + + P VH GA G CAL+T+ ++++ E +DVFQ K + L
Sbjct: 711 SIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQ 770
Query: 1390 RPGVFTDIEQYQFIYKAM 1407
RP + +EQY+F YK +
Sbjct: 771 RPHMVQTLEQYEFCYKVV 788
Score = 195 bits (495), Expect = 3e-49
Identities = 103/298 (34%), Positives = 168/298 (56%), Gaps = 19/298 (6%)
Query: 828 IPVKQFVKHIGELYSN----NQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINI 883
+ V H+ ++Y+ + +G E+F+++ N N P N KNR + I
Sbjct: 509 LEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQ-NDKMRTGNLPANMKKNRVLQI 567
Query: 884 LAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQN 943
+ Y+ +RV + G+++ +DY+NA+++DGY + +YIA+QGPL T EDFWRMIWE
Sbjct: 568 IPYEFNRVIIPVKRGEEN--TDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWK 625
Query: 944 TGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKK 1003
+ IVM+T L E+G+ KC QYWP++ YG+I V LK + YTVR + NT+ K
Sbjct: 626 SCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENK 685
Query: 1004 GQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETG-PVLVHCSA 1062
R + Q+H+ WP++G+P +++ + + P+ VHCSA
Sbjct: 686 S-----------RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSA 734
Query: 1063 GVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI 1120
G GRTGT+ + ++L+++K + ++V +K +R QR ++VQT EQY F + + E I
Sbjct: 735 GAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI 792
Score = 113 bits (283), Expect = 1e-24
Identities = 77/264 (29%), Positives = 121/264 (45%), Gaps = 14/264 (5%)
Query: 1152 KQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYI 1211
++F + C + C +A KE NKEKNR +++P + +RV L P+ G+ +DYINAS+I
Sbjct: 243 EEFNALPACPIQ-ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFI 301
Query: 1212 MGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFV-YWPSREESM 1270
GY N+FI Q P T DFWRMIW+ N IVM+ + + E + YWP +
Sbjct: 302 NGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ---- 357
Query: 1271 NCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLE----VRHFQCPKWPNPDAPI 1326
C + +S + + + + + F ++ D + + F WP+ P
Sbjct: 358 GCWTYGNIRVSVEDVTVLVD--YTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPF 415
Query: 1327 SSTFELINVIKEEALTRD--GPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAK 1384
+ L + K +A G +VH G G + + + E VDV+
Sbjct: 416 TPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVS 475
Query: 1385 MINLMRPGVFTDIEQYQFIYKAML 1408
I R + QY FIY+A+L
Sbjct: 476 RIRAQRCQMVQTDMQYVFIYQALL 499
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 380 bits (976), Expect = e-105
Identities = 230/657 (35%), Positives = 359/657 (54%), Gaps = 54/657 (8%)
Query: 783 SGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPI----PDDME--------AIPV 830
S R ++G Q + + + S P +I P P +M AI V
Sbjct: 812 SASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRV 871
Query: 831 KQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSR 890
++HI ++ +GF E++E + TA+ EN++KNRY NI++YDHSR
Sbjct: 872 ADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKED---ENRNKNRYGNIISYDHSR 928
Query: 891 VKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMI 950
V+L L G HSDYINANY+DGY++ + YIATQGP++ T +DFWRMIW++N+ IVM+
Sbjct: 929 VRLLVLDG--DPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMV 986
Query: 951 TNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPK 1010
TNLVE GR KC +YWP +++E YG+I VTL T+ A Y +R F+++ K
Sbjct: 987 TNLVEVGRVKCVRYWP-DDTEVYGDIKVTLIETEPLAEYVIRTFTVQK-----------K 1034
Query: 1011 GRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTY 1070
G R + +H+T WPD GVP YA +L FVR+ PE GP++VHCSAG GRTG +
Sbjct: 1035 GYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCF 1094
Query: 1071 IVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSN 1130
I ID+ML +++ V++ ++ +R QR LVQTEEQY+F+HDA+LEA L T +
Sbjct: 1095 IAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVC 1154
Query: 1131 QLHS-YVNSILIPGVGGKTRLEKQFKL--VTQCNAKYVECFSAQKECNKEKNRNSSVVPS 1187
+ S Y N + ++++ +F+ + + +C N +KNR+ V+P
Sbjct: 1155 EFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPL 1214
Query: 1188 ERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIV 1247
+R L + G + ++YINA+ + + + F++TQHPLP+T DFWR+++D+N +V
Sbjct: 1215 DRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVV 1273
Query: 1248 MLPDNQSLAEDEFVYWPSREESMNCEA-FTVTLISKDRLCLSNEEQIIIHDFI----LEA 1302
ML + A+ YWP E++ C V +S D ++ IIH +
Sbjct: 1274 ML-NEMDTAQFCMQYWP--EKTSGCYGPIQVEFVSAD------IDEDIIHRIFRICNMAR 1324
Query: 1303 TQDDYVLEVRHFQCPKWPNPDAPISSTFELINVIK------EEALTRDGPTIVHDEYGAV 1356
QD Y + V+H Q WP S L+ V++ E+ R+G T+VH G
Sbjct: 1325 PQDGYRI-VQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGG 1383
Query: 1357 SAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST 1413
+G CA+ ++ + ++ +N +DVF + K + + + +EQY+F+Y+ L +S+
Sbjct: 1384 RSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1440
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 380 bits (976), Expect = e-105
Identities = 230/657 (35%), Positives = 359/657 (54%), Gaps = 54/657 (8%)
Query: 783 SGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPI----PDDME--------AIPV 830
S R ++G Q + + + S P +I P P +M AI V
Sbjct: 831 SASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRV 890
Query: 831 KQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSR 890
++HI ++ +GF E++E + TA+ EN++KNRY NI++YDHSR
Sbjct: 891 ADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKED---ENRNKNRYGNIISYDHSR 947
Query: 891 VKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMI 950
V+L L G HSDYINANY+DGY++ + YIATQGP++ T +DFWRMIW++N+ IVM+
Sbjct: 948 VRLLVLDG--DPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMV 1005
Query: 951 TNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPK 1010
TNLVE GR KC +YWP +++E YG+I VTL T+ A Y +R F+++ K
Sbjct: 1006 TNLVEVGRVKCVRYWP-DDTEVYGDIKVTLIETEPLAEYVIRTFTVQK-----------K 1053
Query: 1011 GRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTY 1070
G R + +H+T WPD GVP YA +L FVR+ PE GP++VHCSAG GRTG +
Sbjct: 1054 GYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCF 1113
Query: 1071 IVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSN 1130
I ID+ML +++ V++ ++ +R QR LVQTEEQY+F+HDA+LEA L T +
Sbjct: 1114 IAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVC 1173
Query: 1131 QLHS-YVNSILIPGVGGKTRLEKQFKL--VTQCNAKYVECFSAQKECNKEKNRNSSVVPS 1187
+ S Y N + ++++ +F+ + + +C N +KNR+ V+P
Sbjct: 1174 EFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPL 1233
Query: 1188 ERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIV 1247
+R L + G + ++YINA+ + + + F++TQHPLP+T DFWR+++D+N +V
Sbjct: 1234 DRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVV 1292
Query: 1248 MLPDNQSLAEDEFVYWPSREESMNCEA-FTVTLISKDRLCLSNEEQIIIHDFI----LEA 1302
ML + A+ YWP E++ C V +S D ++ IIH +
Sbjct: 1293 ML-NEMDTAQFCMQYWP--EKTSGCYGPIQVEFVSAD------IDEDIIHRIFRICNMAR 1343
Query: 1303 TQDDYVLEVRHFQCPKWPNPDAPISSTFELINVIK------EEALTRDGPTIVHDEYGAV 1356
QD Y + V+H Q WP S L+ V++ E+ R+G T+VH G
Sbjct: 1344 PQDGYRI-VQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGG 1402
Query: 1357 SAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST 1413
+G CA+ ++ + ++ +N +DVF + K + + + +EQY+F+Y+ L +S+
Sbjct: 1403 RSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1459
>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
precursor [Homo sapiens]
Length = 700
Score = 375 bits (963), Expect = e-103
Identities = 250/719 (34%), Positives = 369/719 (51%), Gaps = 59/719 (8%)
Query: 703 RGDRFSEDSRFITVNPAEKNTSGMISRPAPGRMEWIIPLIVVSALTFVCLILLIAVLVYW 762
RG+ + DS T TSG P PG + ++ +++ L + ++LL A +
Sbjct: 21 RGNETTADSNETTT------TSGP---PDPGASQPLLAWLLLPLLLLLLVLLLAAYFFRF 71
Query: 763 RGCNKIKSKGFPRRFREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIP 822
R +R V +S ++ G +E+ RV+ P P
Sbjct: 72 R----------KQRKAVVSTSDKKMPNG----------ILEEQEQQRVMLLSRSP--SGP 109
Query: 823 DDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYIN 882
IPV+ + I +++ F E+F + + + T E +N EN+ KNRY N
Sbjct: 110 KKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLP--SGHIQGTFELANKEENREKNRYPN 167
Query: 883 ILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQ 942
IL DHSRV L L G SDYINA+Y+DGY + +IA QGP + T DFWRM+WEQ
Sbjct: 168 ILPNDHSRVILSQLDGIPC--SDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQ 225
Query: 943 NTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVK 1002
+ IVM+TNL E+ KC QYWP + YGNI V ++ + YT+R+F I
Sbjct: 226 KSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCI------ 279
Query: 1003 KGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSA 1062
Q P G + R+V Q H+T WPD GVP + +L F+++ GP++VHCSA
Sbjct: 280 --QPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSA 337
Query: 1063 GVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILG 1122
GVGRTGT+IVID+M+ + + V+V F+ IR QR +VQT+ QY FI+ ALLE L
Sbjct: 338 GVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLY 397
Query: 1123 KETEVSSNQLHSYVNSILIPGVG-GKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRN 1181
+TE+ + L ++ ++ K LE++F+ +T + N +K R
Sbjct: 398 GDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARV 457
Query: 1182 SSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDH 1241
++P + RV L+ G + TDYINAS+I GY + + FI TQ PL HT +DFWRMIW+
Sbjct: 458 IQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEW 517
Query: 1242 NAQIIVMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFIL 1300
+ IVML + Q +D+ + YWP+ E S+ T+ I D L E I I DF++
Sbjct: 518 KSHTIVMLTEVQEREQDKCYQYWPT-EGSVTHGEITIE-IKNDTL----SEAISIRDFLV 571
Query: 1301 -----EATQDDYVLEVRHFQCPKWPNPDAPI--SSTFELINVI-KEEALTRDGPTIVHDE 1352
+A Q++ V VR F WP P +LI + K++ T + P VH
Sbjct: 572 TLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCS 631
Query: 1353 YGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV 1411
GA G AL+ + ++++ E +DVFQ K + L RP + +EQY+F YK + +
Sbjct: 632 AGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI 690
>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
[Homo sapiens]
Length = 642
Score = 374 bits (959), Expect = e-103
Identities = 225/594 (37%), Positives = 325/594 (54%), Gaps = 28/594 (4%)
Query: 828 IPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYD 887
IPV+ + I +++ F E+F + + + T E +N EN+ KNRY NIL D
Sbjct: 57 IPVEHLEEEIRIRSADDCKQFREEFNSLP--SGHIQGTFELANKEENREKNRYPNILPND 114
Query: 888 HSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGII 947
HSRV L L G SDYINA+Y+DGY + +IA QGP + T DFWRM+WEQ + I
Sbjct: 115 HSRVILSQLDGIPC--SDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATI 172
Query: 948 VMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKG 1007
VM+TNL E+ KC QYWP + YGNI V ++ + YT+R+F I Q
Sbjct: 173 VMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCI--------QPQ 224
Query: 1008 NPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRT 1067
P G + R+V Q H+T WPD GVP + +L F+++ GP++VHCSAGVGRT
Sbjct: 225 LPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRT 284
Query: 1068 GTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEV 1127
GT+IVID+M+ + + V+V F+ IR QR +VQT+ QY FI+ ALLE L +TE+
Sbjct: 285 GTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTEL 344
Query: 1128 SSNQLHSYVNSILIPGVG-GKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVP 1186
+ L ++ ++ K LE++F+ +T + N +K R ++P
Sbjct: 345 DVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIP 404
Query: 1187 SERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQII 1246
+ RV L+ G + TDYINAS+I GY + + FI TQ PL HT +DFWRMIW+ + I
Sbjct: 405 YDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTI 464
Query: 1247 VMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFIL----- 1300
VML + Q +D+ + YWP+ E S+ T+ I D L E I I DF++
Sbjct: 465 VMLTEVQEREQDKCYQYWPT-EGSVTHGEITIE-IKNDTL----SEAISIRDFLVTLNQP 518
Query: 1301 EATQDDYVLEVRHFQCPKWPNPDAPI--SSTFELINVI-KEEALTRDGPTIVHDEYGAVS 1357
+A Q++ V VR F WP P +LI + K++ T + P VH GA
Sbjct: 519 QARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGR 578
Query: 1358 AGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV 1411
G AL+ + ++++ E +DVFQ K + L RP + +EQY+F YK + +
Sbjct: 579 TGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI 632
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 368 bits (945), Expect = e-101
Identities = 220/599 (36%), Positives = 341/599 (56%), Gaps = 38/599 (6%)
Query: 827 AIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAY 886
AI V ++HI ++ +GF E++E + + + EN+ KNRY NI+AY
Sbjct: 879 AIRVADLLQHITQMKCAEGYGFKEEYESFFE---GQSAPWDSAKKDENRMKNRYGNIIAY 935
Query: 887 DHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGI 946
DHSRV+L+ + G +SDYIN NY+DGY++ YIATQGP++ T DFWRM+W +NT
Sbjct: 936 DHSRVRLQTIEG--DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTAS 993
Query: 947 IVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQK 1006
I+M+TNLVE GR KC +YWP +++E Y +I VTL T++ A Y +R F++
Sbjct: 994 IIMVTNLVEVGRVKCCKYWP-DDTEIYKDIKVTLIETELLAEYVIRTFAVEK-------- 1044
Query: 1007 GNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGR 1066
+G R + Q+H+T WPD GVP +A +L FVR+ + P GP++VHCSAG GR
Sbjct: 1045 ---RGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGR 1101
Query: 1067 TGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE 1126
TG +IVID ML + + V++ ++ +R++R +VQTEEQY+FIHDA+LEA L +T
Sbjct: 1102 TGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTS 1161
Query: 1127 VSSNQLHS-YVNSILIPGVGGKTRLEKQFKLVTQC--NAKYVECFSAQKECNKEKNRNSS 1183
V ++Q+ S Y + + ++++++F+ + + +C A N EKNR
Sbjct: 1162 VPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMD 1221
Query: 1184 VVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNA 1243
++P +R L + G + ++YINA+ + Y + + FI+TQHPLP+T KDFWR++ D++
Sbjct: 1222 ILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHC 1280
Query: 1244 QIIVMLPDNQSLAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFIL--- 1300
+VML D A+ YWP + V +S D EE II F +
Sbjct: 1281 TSVVMLNDVDP-AQLCPQYWPENGVHRH-GPIQVEFVSADL-----EEDIISRIFRIYNA 1333
Query: 1301 EATQDDYVLEVRHFQCPKWP-NPDAPIS--STFELINVI---KEEALTRDGPTIVHDEYG 1354
QD Y + V+ FQ WP D P+S S +LI + +EE +G T+VH G
Sbjct: 1334 ARPQDGYRM-VQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNG 1392
Query: 1355 AVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST 1413
+G CA++ + + L ++ VDVF K + +P + ++QY+F Y+ L +++
Sbjct: 1393 GGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1451
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 368 bits (945), Expect = e-101
Identities = 220/599 (36%), Positives = 341/599 (56%), Gaps = 38/599 (6%)
Query: 827 AIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAY 886
AI V ++HI ++ +GF E++E + + + EN+ KNRY NI+AY
Sbjct: 892 AIRVADLLQHITQMKCAEGYGFKEEYESFFE---GQSAPWDSAKKDENRMKNRYGNIIAY 948
Query: 887 DHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGI 946
DHSRV+L+ + G +SDYIN NY+DGY++ YIATQGP++ T DFWRM+W +NT
Sbjct: 949 DHSRVRLQTIEG--DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTAS 1006
Query: 947 IVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQK 1006
I+M+TNLVE GR KC +YWP +++E Y +I VTL T++ A Y +R F++
Sbjct: 1007 IIMVTNLVEVGRVKCCKYWP-DDTEIYKDIKVTLIETELLAEYVIRTFAVEK-------- 1057
Query: 1007 GNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGR 1066
+G R + Q+H+T WPD GVP +A +L FVR+ + P GP++VHCSAG GR
Sbjct: 1058 ---RGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGR 1114
Query: 1067 TGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE 1126
TG +IVID ML + + V++ ++ +R++R +VQTEEQY+FIHDA+LEA L +T
Sbjct: 1115 TGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTS 1174
Query: 1127 VSSNQLHS-YVNSILIPGVGGKTRLEKQFKLVTQC--NAKYVECFSAQKECNKEKNRNSS 1183
V ++Q+ S Y + + ++++++F+ + + +C A N EKNR
Sbjct: 1175 VPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMD 1234
Query: 1184 VVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNA 1243
++P +R L + G + ++YINA+ + Y + + FI+TQHPLP+T KDFWR++ D++
Sbjct: 1235 ILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHC 1293
Query: 1244 QIIVMLPDNQSLAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFIL--- 1300
+VML D A+ YWP + V +S D EE II F +
Sbjct: 1294 TSVVMLNDVDP-AQLCPQYWPENGVHRH-GPIQVEFVSADL-----EEDIISRIFRIYNA 1346
Query: 1301 EATQDDYVLEVRHFQCPKWP-NPDAPIS--STFELINVI---KEEALTRDGPTIVHDEYG 1354
QD Y + V+ FQ WP D P+S S +LI + +EE +G T+VH G
Sbjct: 1347 ARPQDGYRM-VQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNG 1405
Query: 1355 AVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST 1413
+G CA++ + + L ++ VDVF K + +P + ++QY+F Y+ L +++
Sbjct: 1406 GGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 360 bits (925), Expect = 4e-99
Identities = 220/608 (36%), Positives = 332/608 (54%), Gaps = 56/608 (9%)
Query: 827 AIPVKQFVKHIGELYSNNQHGFSEDFE---EVQRCTADMNITAEHSNHPENKHKNRYINI 883
AI V ++HI + +++ +GF E++E E Q + D+ + +N+ KNRY NI
Sbjct: 867 AIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDV------AKKDQNRAKNRYGNI 920
Query: 884 LAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQN 943
+AYDHSRV L+P+ +D SDYINANY+DGY + YIATQGP+ T DFWRMIW++
Sbjct: 921 IAYDHSRVILQPV--EDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQ 978
Query: 944 TGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKK 1003
+ IVM+TNLVE GR KC +YWP +++E YG+ VT + A Y VR F++
Sbjct: 979 SACIVMVTNLVEVGRVKCYKYWP-DDTEVYGDFKVTCVEMEPLAEYVVRTFTLER----- 1032
Query: 1004 GQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAG 1063
+G R V Q+H+T WPD GVP +A +L+F+RR + P GP++VHCSAG
Sbjct: 1033 ------RGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAG 1086
Query: 1064 VGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGK 1123
GRTG YIVID ML + + V++ +K +R++R +VQTEEQYIFIHDA+LEA L
Sbjct: 1087 AGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCG 1146
Query: 1124 ETEVSSNQLH-SYVNSILIPGVGGKTRLEKQFKLVTQCNAKY--VECFSAQKECNKEKNR 1180
ET + + +Y + I I + L+ +F+ + + +C A N +KNR
Sbjct: 1147 ETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNR 1206
Query: 1181 NSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWD 1240
++P +R L + G + ++YINA+ + Y + FI+TQ+PLP+T KDFWR+++D
Sbjct: 1207 FMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYD 1265
Query: 1241 HNAQIIVMLPDNQSLAEDEFVYWPS---------REESMNCEAFTVTLISKDRLCLSNEE 1291
+ IVML + L++ YWP + E M+C + R+C
Sbjct: 1266 YGCTSIVML-NEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRIC----- 1319
Query: 1292 QIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISSTFELINVI------KEEALTRDG 1345
L Q+ Y++ V+ FQ W + S + +I +EE +G
Sbjct: 1320 -------NLTRPQEGYLM-VQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEG 1371
Query: 1346 PTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYK 1405
TI+H G +GM CA+ + + ++ +N VDVF K + +P + EQY+F Y
Sbjct: 1372 RTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYD 1431
Query: 1406 AMLSLVST 1413
L + +
Sbjct: 1432 VALEYLES 1439
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 354 bits (908), Expect = 4e-97
Identities = 220/614 (35%), Positives = 332/614 (54%), Gaps = 62/614 (10%)
Query: 827 AIPVKQFVKHIGELYSNNQHGFSEDFE---EVQRCTADMNITAEHSNHPENKHKNRYINI 883
AI V ++HI + +++ +GF E++E E Q + D+ + +N+ KNRY NI
Sbjct: 867 AIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDV------AKKDQNRAKNRYGNI 920
Query: 884 LAYDHSRVKLRPLPGKDSKHSDYINANYVD------GYNKAKAYIATQGPLKSTFEDFWR 937
+AYDHSRV L+P+ +D SDYINANY+D GY + YIATQGP+ T DFWR
Sbjct: 921 IAYDHSRVILQPV--EDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWR 978
Query: 938 MIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIR 997
MIW++ + IVM+TNLVE GR KC +YWP +++E YG+ VT + A Y VR F++
Sbjct: 979 MIWQEQSACIVMVTNLVEVGRVKCYKYWP-DDTEVYGDFKVTCVEMEPLAEYVVRTFTLE 1037
Query: 998 NTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVL 1057
+G R V Q+H+T WPD GVP +A +L+F+RR + P GP++
Sbjct: 1038 R-----------RGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIV 1086
Query: 1058 VHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALL 1117
VHCSAG GRTG YIVID ML + + V++ +K +R++R +VQTEEQYIFIHDA+L
Sbjct: 1087 VHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAIL 1146
Query: 1118 EAILGKETEVSSNQLH-SYVNSILIPGVGGKTRLEKQFKLVTQCNAKY--VECFSAQKEC 1174
EA L ET + + +Y + I I + L+ +F+ + + +C A
Sbjct: 1147 EACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPR 1206
Query: 1175 NKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDF 1234
N +KNR ++P +R L + G + ++YINA+ + Y + FI+TQ+PLP+T KDF
Sbjct: 1207 NHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDF 1265
Query: 1235 WRMIWDHNAQIIVMLPDNQSLAEDEFVYWPS---------REESMNCEAFTVTLISKDRL 1285
WR+++D+ IVML + L++ YWP + E M+C + R+
Sbjct: 1266 WRLVYDYGCTSIVML-NEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRI 1324
Query: 1286 CLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISSTFELINVI------KEE 1339
C L Q+ Y++ V+ FQ W + S + +I +EE
Sbjct: 1325 C------------NLTRPQEGYLM-VQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEE 1371
Query: 1340 ALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQ 1399
+G TI+H G +GM CA+ + + ++ +N VDVF K + +P + EQ
Sbjct: 1372 CEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQ 1431
Query: 1400 YQFIYKAMLSLVST 1413
Y+F Y L + +
Sbjct: 1432 YRFCYDVALEYLES 1445
>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
precursor [Homo sapiens]
Length = 1436
Score = 340 bits (871), Expect = 8e-93
Identities = 213/603 (35%), Positives = 322/603 (53%), Gaps = 43/603 (7%)
Query: 827 AIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHK-NRYINILA 885
A+ V ++HI ++ + +GF +++E + ++K K +R + A
Sbjct: 863 AVRVADLLQHINQMKTAEGYGFKQEYESF--------FEGWDATKKKDKVKGSRQEPMPA 914
Query: 886 YDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTG 945
YD RVKL P+ G ++DYINANY+DGY+++ +IATQGP DFWRM+W+++
Sbjct: 915 YDRHRVKLHPMLG--DPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCS 972
Query: 946 IIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQ 1005
IVMIT LVE GR KC +YWP E+S+ YG+I + L T+ A Y VR F++
Sbjct: 973 SIVMITKLVEVGRVKCSRYWP-EDSDTYGDIKIMLVKTETLAEYVVRTFALER------- 1024
Query: 1006 KGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVG 1065
+G V Q+H+T WP+ GVP +A +L F+RR A+ P+ GP+++HCSAG G
Sbjct: 1025 ----RGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTG 1080
Query: 1066 RTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET 1125
RTG YIV+D ML + + V++ +K + ++R ++QTEEQYIFIHDA+LEA L ET
Sbjct: 1081 RTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGET 1140
Query: 1126 EVSSNQLH-SYVNSILIPGVGGKTRLEKQFKLVTQCN--AKYVECFSAQKECNKEKNRNS 1182
+ ++ +Y I I ++L ++F+ + EC A N++KNR+
Sbjct: 1141 TIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSM 1200
Query: 1183 SVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHN 1242
V+P +R L G +YINA+ Y RS FI+T HPL TT DFWR+++D+
Sbjct: 1201 DVLPPDRCLPFLISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYG 1259
Query: 1243 AQIIVMLPD-NQS-LAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFIL 1300
IVML NQS A YWP L+ + + + +E ++ F +
Sbjct: 1260 CTSIVMLNQLNQSNSAWPCLQYWPEPGRQQ------YGLMEVEFMSGTADEDLVARVFRV 1313
Query: 1301 E---ATQDDYVLEVRHFQCPKW----PNPDAPISSTFELINVIKEEALTRDGPTIVHDEY 1353
+ Q+ ++L VRHFQ +W PD+ + L V K +A + DG TIVH
Sbjct: 1314 QNISRLQEGHLL-VRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLN 1372
Query: 1354 GAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST 1413
G +G CA T+ + + N VDVF AK + +P + ++QY F Y L +
Sbjct: 1373 GGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEG 1432
Query: 1414 KEN 1416
E+
Sbjct: 1433 LES 1435
>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
precursor [Homo sapiens]
Length = 1446
Score = 340 bits (871), Expect = 8e-93
Identities = 213/603 (35%), Positives = 322/603 (53%), Gaps = 43/603 (7%)
Query: 827 AIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHK-NRYINILA 885
A+ V ++HI ++ + +GF +++E + ++K K +R + A
Sbjct: 873 AVRVADLLQHINQMKTAEGYGFKQEYESF--------FEGWDATKKKDKVKGSRQEPMPA 924
Query: 886 YDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTG 945
YD RVKL P+ G ++DYINANY+DGY+++ +IATQGP DFWRM+W+++
Sbjct: 925 YDRHRVKLHPMLG--DPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCS 982
Query: 946 IIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQ 1005
IVMIT LVE GR KC +YWP E+S+ YG+I + L T+ A Y VR F++
Sbjct: 983 SIVMITKLVEVGRVKCSRYWP-EDSDTYGDIKIMLVKTETLAEYVVRTFALER------- 1034
Query: 1006 KGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVG 1065
+G V Q+H+T WP+ GVP +A +L F+RR A+ P+ GP+++HCSAG G
Sbjct: 1035 ----RGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTG 1090
Query: 1066 RTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET 1125
RTG YIV+D ML + + V++ +K + ++R ++QTEEQYIFIHDA+LEA L ET
Sbjct: 1091 RTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGET 1150
Query: 1126 EVSSNQLH-SYVNSILIPGVGGKTRLEKQFKLVTQCN--AKYVECFSAQKECNKEKNRNS 1182
+ ++ +Y I I ++L ++F+ + EC A N++KNR+
Sbjct: 1151 TIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSM 1210
Query: 1183 SVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHN 1242
V+P +R L G +YINA+ Y RS FI+T HPL TT DFWR+++D+
Sbjct: 1211 DVLPPDRCLPFLISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYG 1269
Query: 1243 AQIIVMLPD-NQS-LAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFIL 1300
IVML NQS A YWP L+ + + + +E ++ F +
Sbjct: 1270 CTSIVMLNQLNQSNSAWPCLQYWPEPGRQQ------YGLMEVEFMSGTADEDLVARVFRV 1323
Query: 1301 E---ATQDDYVLEVRHFQCPKW----PNPDAPISSTFELINVIKEEALTRDGPTIVHDEY 1353
+ Q+ ++L VRHFQ +W PD+ + L V K +A + DG TIVH
Sbjct: 1324 QNISRLQEGHLL-VRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLN 1382
Query: 1354 GAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST 1413
G +G CA T+ + + N VDVF AK + +P + ++QY F Y L +
Sbjct: 1383 GGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEG 1442
Query: 1414 KEN 1416
E+
Sbjct: 1443 LES 1445
>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
precursor [Homo sapiens]
Length = 1442
Score = 333 bits (854), Expect = 7e-91
Identities = 213/609 (34%), Positives = 322/609 (52%), Gaps = 49/609 (8%)
Query: 827 AIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHK-NRYINILA 885
A+ V ++HI ++ + +GF +++E + ++K K +R + A
Sbjct: 863 AVRVADLLQHINQMKTAEGYGFKQEYESF--------FEGWDATKKKDKVKGSRQEPMPA 914
Query: 886 YDHSRVKLRPLPGKDSKHSDYINANYVD------GYNKAKAYIATQGPLKSTFEDFWRMI 939
YD RVKL P+ G ++DYINANY+D GY+++ +IATQGP DFWRM+
Sbjct: 915 YDRHRVKLHPMLG--DPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMV 972
Query: 940 WEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNT 999
W+++ IVMIT LVE GR KC +YWP E+S+ YG+I + L T+ A Y VR F++
Sbjct: 973 WQEHCSSIVMITKLVEVGRVKCSRYWP-EDSDTYGDIKIMLVKTETLAEYVVRTFALER- 1030
Query: 1000 KVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVH 1059
+G V Q+H+T WP+ GVP +A +L F+RR A+ P+ GP+++H
Sbjct: 1031 ----------RGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIH 1080
Query: 1060 CSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEA 1119
CSAG GRTG YIV+D ML + + V++ +K + ++R ++QTEEQYIFIHDA+LEA
Sbjct: 1081 CSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA 1140
Query: 1120 ILGKETEVSSNQLH-SYVNSILIPGVGGKTRLEKQFKLVTQCN--AKYVECFSAQKECNK 1176
L ET + ++ +Y I I ++L ++F+ + EC A N+
Sbjct: 1141 CLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR 1200
Query: 1177 EKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWR 1236
+KNR+ V+P +R L G +YINA+ Y RS FI+T HPL TT DFWR
Sbjct: 1201 DKNRSMDVLPPDRCLPFLISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWR 1259
Query: 1237 MIWDHNAQIIVMLPD-NQS-LAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQII 1294
+++D+ IVML NQS A YWP L+ + + + +E ++
Sbjct: 1260 LVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQ------YGLMEVEFMSGTADEDLV 1313
Query: 1295 IHDFILE---ATQDDYVLEVRHFQCPKW----PNPDAPISSTFELINVIKEEALTRDGPT 1347
F ++ Q+ ++L VRHFQ +W PD+ + L V K +A + DG T
Sbjct: 1314 ARVFRVQNISRLQEGHLL-VRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRT 1372
Query: 1348 IVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAM 1407
IVH G +G CA T+ + + N VDVF AK + +P + ++QY F Y
Sbjct: 1373 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1432
Query: 1408 LSLVSTKEN 1416
L + E+
Sbjct: 1433 LEYLEGLES 1441
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
precursor [Homo sapiens]
Length = 1256
Score = 315 bits (806), Expect = 3e-85
Identities = 202/601 (33%), Positives = 307/601 (51%), Gaps = 65/601 (10%)
Query: 848 FSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYI 907
F +F+ + R + I + + P N++KNRY++IL YD++RV+L + G S+YI
Sbjct: 603 FLAEFQSIPRVFSKFPI--KEARKPFNQNKNRYVDILPYDYNRVELSEINGDAG--SNYI 658
Query: 908 NANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPT 967
NA+Y+DG+ + + YIA QGP T +DFWRMIWEQ +IVM+T E R KC +YWP+
Sbjct: 659 NASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPS 718
Query: 968 --ENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQ 1025
E + +G+++V + K Y +++ +I N K K R V +T
Sbjct: 719 MEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA----------TGREVTHIQFTS 768
Query: 1026 WPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKST 1085
WPD GVPE +L RR +A +GP++VHCSAGVGRTGTYI ID+ML+ ++ ++
Sbjct: 769 WPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENK 828
Query: 1086 VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVG 1145
V+V G++ +R QR +VQ E QYI IH AL+E ETEV+ ++LH Y++++
Sbjct: 829 VDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPP 888
Query: 1146 GK-TRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGM---- 1200
+ + LE +F+ + + + Q+E NK KNRNS+V+P + RV L M
Sbjct: 889 SEPSPLEAEFQRLPSYRSWRTQHIGNQEE-NKSKNRNSNVIPYDYNRVPLKHELEMSKES 947
Query: 1201 ---------------KGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQI 1245
+ + YINAS+IM Y++ I Q PL T DFW+MI+ ++
Sbjct: 948 EHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKV 1007
Query: 1246 IVMLP-----DNQSLAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFIL 1300
IVML D + A+ YW ++ T I D + F L
Sbjct: 1008 IVMLTELKHGDQEICAQ----YWGEGKQ-------TYGDIEVDLKDTDKSSTYTLRVFEL 1056
Query: 1301 EATQDDYVLEVRHFQCPKWPNPDAPI--SSTFELINVIKEEALTRDG----------PTI 1348
++ V +Q W P +I V+K++ ++ P +
Sbjct: 1057 RHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1116
Query: 1349 VHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAML 1408
+H G+ G+ CAL L + E E VD+FQV K + RPG+ + EQYQF+Y +
Sbjct: 1117 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA 1176
Query: 1409 S 1409
S
Sbjct: 1177 S 1177
Score = 150 bits (380), Expect = 7e-36
Identities = 94/305 (30%), Positives = 153/305 (50%), Gaps = 40/305 (13%)
Query: 854 EVQRCTADMNITAEH-SNHPENKHKNRYINILAYDHSRVKLRPL--PGKDSKH------- 903
E QR + + +H N ENK KNR N++ YD++RV L+ K+S+H
Sbjct: 897 EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 956
Query: 904 --------SDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVE 955
S YINA+++ Y K + IA QGPLK T DFW+MI+++ +IVM+T L
Sbjct: 957 DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 1016
Query: 956 KGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNE 1015
+ C QYW E + YG+I V LK T + YT+R F +R++K R++
Sbjct: 1017 GDQEICAQYWG-EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSK-----------RKDS 1064
Query: 1016 RVVIQYHYTQWPDMGVPEYALPVLTFVR----------RSSAARMPETGPVLVHCSAGVG 1065
R V QY YT W +P +++ ++ S + ++ P+L+HC G
Sbjct: 1065 RTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQ 1124
Query: 1066 RTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET 1125
+TG + + ++L+ + + V++ +K +R R +V T EQY F++D + +
Sbjct: 1125 QTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNG 1184
Query: 1126 EVSSN 1130
+V N
Sbjct: 1185 QVKKN 1189
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
precursor [Homo sapiens]
Length = 1304
Score = 315 bits (806), Expect = 3e-85
Identities = 202/601 (33%), Positives = 307/601 (51%), Gaps = 65/601 (10%)
Query: 848 FSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYI 907
F +F+ + R + I + + P N++KNRY++IL YD++RV+L + G S+YI
Sbjct: 651 FLAEFQSIPRVFSKFPI--KEARKPFNQNKNRYVDILPYDYNRVELSEINGDAG--SNYI 706
Query: 908 NANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPT 967
NA+Y+DG+ + + YIA QGP T +DFWRMIWEQ +IVM+T E R KC +YWP+
Sbjct: 707 NASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPS 766
Query: 968 --ENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQ 1025
E + +G+++V + K Y +++ +I N K K R V +T
Sbjct: 767 MEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA----------TGREVTHIQFTS 816
Query: 1026 WPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKST 1085
WPD GVPE +L RR +A +GP++VHCSAGVGRTGTYI ID+ML+ ++ ++
Sbjct: 817 WPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENK 876
Query: 1086 VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVG 1145
V+V G++ +R QR +VQ E QYI IH AL+E ETEV+ ++LH Y++++
Sbjct: 877 VDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPP 936
Query: 1146 GK-TRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGM---- 1200
+ + LE +F+ + + + Q+E NK KNRNS+V+P + RV L M
Sbjct: 937 SEPSPLEAEFQRLPSYRSWRTQHIGNQEE-NKSKNRNSNVIPYDYNRVPLKHELEMSKES 995
Query: 1201 ---------------KGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQI 1245
+ + YINAS+IM Y++ I Q PL T DFW+MI+ ++
Sbjct: 996 EHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKV 1055
Query: 1246 IVMLP-----DNQSLAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFIL 1300
IVML D + A+ YW ++ T I D + F L
Sbjct: 1056 IVMLTELKHGDQEICAQ----YWGEGKQ-------TYGDIEVDLKDTDKSSTYTLRVFEL 1104
Query: 1301 EATQDDYVLEVRHFQCPKWPNPDAPI--SSTFELINVIKEEALTRDG----------PTI 1348
++ V +Q W P +I V+K++ ++ P +
Sbjct: 1105 RHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1164
Query: 1349 VHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAML 1408
+H G+ G+ CAL L + E E VD+FQV K + RPG+ + EQYQF+Y +
Sbjct: 1165 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA 1224
Query: 1409 S 1409
S
Sbjct: 1225 S 1225
Score = 150 bits (380), Expect = 7e-36
Identities = 94/305 (30%), Positives = 153/305 (50%), Gaps = 40/305 (13%)
Query: 854 EVQRCTADMNITAEH-SNHPENKHKNRYINILAYDHSRVKLRPL--PGKDSKH------- 903
E QR + + +H N ENK KNR N++ YD++RV L+ K+S+H
Sbjct: 945 EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 1004
Query: 904 --------SDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVE 955
S YINA+++ Y K + IA QGPLK T DFW+MI+++ +IVM+T L
Sbjct: 1005 DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 1064
Query: 956 KGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNE 1015
+ C QYW E + YG+I V LK T + YT+R F +R++K R++
Sbjct: 1065 GDQEICAQYWG-EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSK-----------RKDS 1112
Query: 1016 RVVIQYHYTQWPDMGVPEYALPVLTFVR----------RSSAARMPETGPVLVHCSAGVG 1065
R V QY YT W +P +++ ++ S + ++ P+L+HC G
Sbjct: 1113 RTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQ 1172
Query: 1066 RTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET 1125
+TG + + ++L+ + + V++ +K +R R +V T EQY F++D + +
Sbjct: 1173 QTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNG 1232
Query: 1126 EVSSN 1130
+V N
Sbjct: 1233 QVKKN 1237
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
precursor [Homo sapiens]
Length = 1143
Score = 315 bits (806), Expect = 3e-85
Identities = 202/601 (33%), Positives = 307/601 (51%), Gaps = 65/601 (10%)
Query: 848 FSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYI 907
F +F+ + R + I + + P N++KNRY++IL YD++RV+L + G S+YI
Sbjct: 490 FLAEFQSIPRVFSKFPI--KEARKPFNQNKNRYVDILPYDYNRVELSEINGDAG--SNYI 545
Query: 908 NANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPT 967
NA+Y+DG+ + + YIA QGP T +DFWRMIWEQ +IVM+T E R KC +YWP+
Sbjct: 546 NASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPS 605
Query: 968 --ENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQ 1025
E + +G+++V + K Y +++ +I N K K R V +T
Sbjct: 606 MEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA----------TGREVTHIQFTS 655
Query: 1026 WPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKST 1085
WPD GVPE +L RR +A +GP++VHCSAGVGRTGTYI ID+ML+ ++ ++
Sbjct: 656 WPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENK 715
Query: 1086 VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVG 1145
V+V G++ +R QR +VQ E QYI IH AL+E ETEV+ ++LH Y++++
Sbjct: 716 VDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPP 775
Query: 1146 GK-TRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGM---- 1200
+ + LE +F+ + + + Q+E NK KNRNS+V+P + RV L M
Sbjct: 776 SEPSPLEAEFQRLPSYRSWRTQHIGNQEE-NKSKNRNSNVIPYDYNRVPLKHELEMSKES 834
Query: 1201 ---------------KGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQI 1245
+ + YINAS+IM Y++ I Q PL T DFW+MI+ ++
Sbjct: 835 EHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKV 894
Query: 1246 IVMLP-----DNQSLAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFIL 1300
IVML D + A+ YW ++ T I D + F L
Sbjct: 895 IVMLTELKHGDQEICAQ----YWGEGKQ-------TYGDIEVDLKDTDKSSTYTLRVFEL 943
Query: 1301 EATQDDYVLEVRHFQCPKWPNPDAPI--SSTFELINVIKEEALTRDG----------PTI 1348
++ V +Q W P +I V+K++ ++ P +
Sbjct: 944 RHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1003
Query: 1349 VHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAML 1408
+H G+ G+ CAL L + E E VD+FQV K + RPG+ + EQYQF+Y +
Sbjct: 1004 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA 1063
Query: 1409 S 1409
S
Sbjct: 1064 S 1064
Score = 150 bits (380), Expect = 7e-36
Identities = 94/305 (30%), Positives = 153/305 (50%), Gaps = 40/305 (13%)
Query: 854 EVQRCTADMNITAEH-SNHPENKHKNRYINILAYDHSRVKLRPL--PGKDSKH------- 903
E QR + + +H N ENK KNR N++ YD++RV L+ K+S+H
Sbjct: 784 EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 843
Query: 904 --------SDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVE 955
S YINA+++ Y K + IA QGPLK T DFW+MI+++ +IVM+T L
Sbjct: 844 DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 903
Query: 956 KGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNE 1015
+ C QYW E + YG+I V LK T + YT+R F +R++K R++
Sbjct: 904 GDQEICAQYWG-EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSK-----------RKDS 951
Query: 1016 RVVIQYHYTQWPDMGVPEYALPVLTFVR----------RSSAARMPETGPVLVHCSAGVG 1065
R V QY YT W +P +++ ++ S + ++ P+L+HC G
Sbjct: 952 RTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQ 1011
Query: 1066 RTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET 1125
+TG + + ++L+ + + V++ +K +R R +V T EQY F++D + +
Sbjct: 1012 QTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNG 1071
Query: 1126 EVSSN 1130
+V N
Sbjct: 1072 QVKKN 1076
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,161,860
Number of Sequences: 37866
Number of extensions: 2928084
Number of successful extensions: 21174
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 372
Number of HSP's successfully gapped in prelim test: 632
Number of HSP's that attempted gapping in prelim test: 14176
Number of HSP's gapped (non-prelim): 4980
length of query: 1445
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1330
effective length of database: 13,892,928
effective search space: 18477594240
effective search space used: 18477594240
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.