Guide to the Human Genome
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Search of human proteins with 193804860

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|193804860 synaptotagmin-like 4 [Homo sapiens]
         (671 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|193804862 synaptotagmin-like 4 [Homo sapiens]                     1351   0.0  
gi|193804860 synaptotagmin-like 4 [Homo sapiens]                     1351   0.0  
gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens]            496   e-140
gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens]             496   e-140
gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens]            489   e-138
gi|46255064 synaptotagmin-like 2 isoform d [Homo sapiens]             301   1e-81
gi|46255062 synaptotagmin-like 2 isoform c [Homo sapiens]             298   8e-81
gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens]            298   1e-80
gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens]            298   1e-80
gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens]             294   2e-79
gi|46255066 synaptotagmin-like 2 isoform e [Homo sapiens]             294   2e-79
gi|46255068 synaptotagmin-like 2 isoform f [Homo sapiens]             289   7e-78
gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens]             285   1e-76
gi|244790016 synaptotagmin-like 2 isoform h [Homo sapiens]            284   2e-76
gi|14249614 synaptotagmin-like 1 [Homo sapiens]                       263   5e-70
gi|110227631 synaptotagmin-like 3 [Homo sapiens]                      213   4e-55
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]            173   5e-43
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]             173   5e-43
gi|211059429 synaptotagmin II [Homo sapiens]                          146   7e-35
gi|31543670 synaptotagmin II [Homo sapiens]                           146   7e-35
gi|92859638 synaptotagmin V [Homo sapiens]                            143   6e-34
gi|6005997 double C2-like domains, beta [Homo sapiens]                139   1e-32
gi|209447073 synaptotagmin I [Homo sapiens]                           135   2e-31
gi|5032139 synaptotagmin I [Homo sapiens]                             135   2e-31
gi|209447070 synaptotagmin I [Homo sapiens]                           135   2e-31
gi|38570146 synaptotagmin VII [Homo sapiens]                          131   2e-30
gi|238550198 synaptotagmin III [Homo sapiens]                         130   5e-30
gi|238550196 synaptotagmin III [Homo sapiens]                         130   5e-30
gi|14150054 synaptotagmin III [Homo sapiens]                          130   5e-30
gi|39752671 synaptotagmin X [Homo sapiens]                            125   1e-28

>gi|193804862 synaptotagmin-like 4 [Homo sapiens]
          Length = 671

 Score = 1351 bits (3496), Expect = 0.0
 Identities = 671/671 (100%), Positives = 671/671 (100%)

Query: 1   MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSD 60
           MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSD
Sbjct: 1   MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSD 60

Query: 61  RTCARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFY 120
           RTCARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFY
Sbjct: 61  RTCARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFY 120

Query: 121 DQKVNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPS 180
           DQKVNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPS
Sbjct: 121 DQKVNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPS 180

Query: 181 VLFEVPKLKSGKSALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKE 240
           VLFEVPKLKSGKSALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKE
Sbjct: 181 VLFEVPKLKSGKSALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKE 240

Query: 241 TQPGGQNVVFVDEGEMIFKKNTRKILRPSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGL 300
           TQPGGQNVVFVDEGEMIFKKNTRKILRPSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGL
Sbjct: 241 TQPGGQNVVFVDEGEMIFKKNTRKILRPSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGL 300

Query: 301 NVDMEEEEEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRI 360
           NVDMEEEEEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRI
Sbjct: 301 NVDMEEEEEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRI 360

Query: 361 AFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTI 420
           AFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTI
Sbjct: 361 AFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTI 420

Query: 421 NPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPL 480
           NPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPL
Sbjct: 421 NPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPL 480

Query: 481 HGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTA 540
           HGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTA
Sbjct: 481 HGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTA 540

Query: 541 AKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELT 600
           AKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELT
Sbjct: 541 AKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELT 600

Query: 601 VWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQL 660
           VWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQL
Sbjct: 601 VWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQL 660

Query: 661 RSSMAKQKLGL 671
           RSSMAKQKLGL
Sbjct: 661 RSSMAKQKLGL 671


>gi|193804860 synaptotagmin-like 4 [Homo sapiens]
          Length = 671

 Score = 1351 bits (3496), Expect = 0.0
 Identities = 671/671 (100%), Positives = 671/671 (100%)

Query: 1   MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSD 60
           MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSD
Sbjct: 1   MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSD 60

Query: 61  RTCARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFY 120
           RTCARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFY
Sbjct: 61  RTCARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFY 120

Query: 121 DQKVNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPS 180
           DQKVNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPS
Sbjct: 121 DQKVNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPS 180

Query: 181 VLFEVPKLKSGKSALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKE 240
           VLFEVPKLKSGKSALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKE
Sbjct: 181 VLFEVPKLKSGKSALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKE 240

Query: 241 TQPGGQNVVFVDEGEMIFKKNTRKILRPSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGL 300
           TQPGGQNVVFVDEGEMIFKKNTRKILRPSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGL
Sbjct: 241 TQPGGQNVVFVDEGEMIFKKNTRKILRPSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGL 300

Query: 301 NVDMEEEEEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRI 360
           NVDMEEEEEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRI
Sbjct: 301 NVDMEEEEEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRI 360

Query: 361 AFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTI 420
           AFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTI
Sbjct: 361 AFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTI 420

Query: 421 NPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPL 480
           NPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPL
Sbjct: 421 NPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPL 480

Query: 481 HGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTA 540
           HGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTA
Sbjct: 481 HGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTA 540

Query: 541 AKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELT 600
           AKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELT
Sbjct: 541 AKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELT 600

Query: 601 VWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQL 660
           VWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQL
Sbjct: 601 VWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQL 660

Query: 661 RSSMAKQKLGL 671
           RSSMAKQKLGL
Sbjct: 661 RSSMAKQKLGL 671


>gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens]
          Length = 730

 Score =  496 bits (1277), Expect = e-140
 Identities = 296/732 (40%), Positives = 420/732 (57%), Gaps = 70/732 (9%)

Query: 2   SELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDR 61
           SE ++LSFL + EK++IL VL+RDE ++K ++KRIR+LKNELLE KR+  K  +Q  + R
Sbjct: 5   SEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGK--TQQEASR 62

Query: 62  TCARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFYD 121
            C  C  +LG +  + + C+ C+  VCR+CR+   NG+W+C VC K  +L+  TG+WF++
Sbjct: 63  VCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWFFE 122

Query: 122 QKVNRFAYRT--GSEIIRMS-LRHKPAVSKRETVGQSLLHQTQMGDIWP--GRKIIQERQ 176
           +K  RF      G++++R S LR  P   + ++  Q+     +  D  P  G+K   +  
Sbjct: 123 EKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQT-RQDAEKSDTSPVAGKKASHDGP 181

Query: 177 KEPSVLFE-----------VPKLKSGKS-ALEAESESLDSFT----ADSDSTSRRDSLDK 220
           K    L              PK  +G+S +L+ + +   S      +D  ST   D  D+
Sbjct: 182 KRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQ 241

Query: 221 ------------SGLFPEWKKMSAPKSQVEKET---QPGGQNVVFVDEGEMIFKKNTRKI 265
                       +G+ P  +   AP ++        + G +N + +   E   ++ T+  
Sbjct: 242 EPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKSH 301

Query: 266 LR---------------PSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGLNVDMEEEEEE 310
            R                S+ ++S +DL          ++  RSKSVPG       EE E
Sbjct: 302 RRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEETE 361

Query: 311 EDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQT 370
           E ID LV   +       + SG S +++ SMMS+YSE GD+GN+ V+G I   + Y  +T
Sbjct: 362 ESIDALVS-SQLSTNTHRLASGLSTTSLNSMMSVYSETGDYGNVKVSGEILLHISYCYKT 420

Query: 371 QSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRY 430
             L + VK C  LA  DE K+R++ YVK+YLLPDKSR  KRKT I+  T NP ++ETL+Y
Sbjct: 421 GGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGT-NPEFNETLKY 479

Query: 431 EIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPT 490
            I  + L  RTLQ SVWH+ RFGRN+FLGE EI  DSW  +   D    L  K+      
Sbjct: 480 TISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDI 539

Query: 491 GLPSHKGELVVSLKYIP-------------ASKTPVGGDRKKSKGGEGGELQVWIKEAKN 537
           GL  +KGEL V L+YIP              +KT   G +K+S    GG L+V+IKEAKN
Sbjct: 540 GL-QYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKN 598

Query: 538 LTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCL 597
           LTA K+GGTSDSFVKGYLLP  +KA+K KT V+KK++NP +NHTF+++G+  +D++++CL
Sbjct: 599 LTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCL 658

Query: 598 ELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGT 657
           ELT+WD+E  +SN FLGGVRL  G+G+S+G+ VDWMDS GEE  LWQKM   PG+  EG 
Sbjct: 659 ELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGV 718

Query: 658 LQLRSSMAKQKL 669
           L LRSSM K +L
Sbjct: 719 LMLRSSMGKCRL 730


>gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens]
          Length = 730

 Score =  496 bits (1277), Expect = e-140
 Identities = 296/732 (40%), Positives = 420/732 (57%), Gaps = 70/732 (9%)

Query: 2   SELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDR 61
           SE ++LSFL + EK++IL VL+RDE ++K ++KRIR+LKNELLE KR+  K  +Q  + R
Sbjct: 5   SEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGK--TQQEASR 62

Query: 62  TCARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFYD 121
            C  C  +LG +  + + C+ C+  VCR+CR+   NG+W+C VC K  +L+  TG+WF++
Sbjct: 63  VCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWFFE 122

Query: 122 QKVNRFAYRT--GSEIIRMS-LRHKPAVSKRETVGQSLLHQTQMGDIWP--GRKIIQERQ 176
           +K  RF      G++++R S LR  P   + ++  Q+     +  D  P  G+K   +  
Sbjct: 123 EKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQT-RQDAEKSDTSPVAGKKASHDGP 181

Query: 177 KEPSVLFE-----------VPKLKSGKS-ALEAESESLDSFT----ADSDSTSRRDSLDK 220
           K    L              PK  +G+S +L+ + +   S      +D  ST   D  D+
Sbjct: 182 KRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQ 241

Query: 221 ------------SGLFPEWKKMSAPKSQVEKET---QPGGQNVVFVDEGEMIFKKNTRKI 265
                       +G+ P  +   AP ++        + G +N + +   E   ++ T+  
Sbjct: 242 EPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKSH 301

Query: 266 LR---------------PSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGLNVDMEEEEEE 310
            R                S+ ++S +DL          ++  RSKSVPG       EE E
Sbjct: 302 RRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEETE 361

Query: 311 EDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQT 370
           E ID LV   +       + SG S +++ SMMS+YSE GD+GN+ V+G I   + Y  +T
Sbjct: 362 ESIDALVS-SQLSTNTHRLASGLSTTSLNSMMSVYSETGDYGNVKVSGEILLHISYCYKT 420

Query: 371 QSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRY 430
             L + VK C  LA  DE K+R++ YVK+YLLPDKSR  KRKT I+  T NP ++ETL+Y
Sbjct: 421 GGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGT-NPEFNETLKY 479

Query: 431 EIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPT 490
            I  + L  RTLQ SVWH+ RFGRN+FLGE EI  DSW  +   D    L  K+      
Sbjct: 480 TISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDI 539

Query: 491 GLPSHKGELVVSLKYIP-------------ASKTPVGGDRKKSKGGEGGELQVWIKEAKN 537
           GL  +KGEL V L+YIP              +KT   G +K+S    GG L+V+IKEAKN
Sbjct: 540 GL-QYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKN 598

Query: 538 LTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCL 597
           LTA K+GGTSDSFVKGYLLP  +KA+K KT V+KK++NP +NHTF+++G+  +D++++CL
Sbjct: 599 LTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCL 658

Query: 598 ELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGT 657
           ELT+WD+E  +SN FLGGVRL  G+G+S+G+ VDWMDS GEE  LWQKM   PG+  EG 
Sbjct: 659 ELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGV 718

Query: 658 LQLRSSMAKQKL 669
           L LRSSM K +L
Sbjct: 719 LMLRSSMGKCRL 730


>gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens]
          Length = 752

 Score =  489 bits (1258), Expect = e-138
 Identities = 300/753 (39%), Positives = 423/753 (56%), Gaps = 90/753 (11%)

Query: 2   SELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDR 61
           SE ++LSFL + EK++IL VL+RDE ++K ++KRIR+LKNELLE KR+  K  +Q  + R
Sbjct: 5   SEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGK--TQQEASR 62

Query: 62  TCARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFYD 121
            C  C  +LG +  + + C+ C+  VCR+CR+   NG+W+C VC K  +L+  TG+WF++
Sbjct: 63  VCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWFFE 122

Query: 122 QKVNRFAYRT--GSEIIRMS-LRHKPAVSKRETVGQSLLHQTQMGDIWP--GRKIIQERQ 176
           +K  RF      G++++R S LR  P   + ++  Q+     +  D  P  G+K   +  
Sbjct: 123 EKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTR-QDAEKSDTSPVAGKKASHDGP 181

Query: 177 KEPSVLFE-----------VPKLKSGKS-ALEAESESLDSFTA----DSDSTSRRDSLDK 220
           K    L              PK  +G+S +L+ + +   S  +    D  ST   D  D+
Sbjct: 182 KRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQ 241

Query: 221 ------------SGLFPEWKKMSAPKSQVEKET---QPGGQNVVFVDEGEMIFKKNTRKI 265
                       +G+ P  +   AP ++        + G +N + +   E   ++ T+  
Sbjct: 242 EPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKSH 301

Query: 266 LR---------------PSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGLNVDMEEEEEE 310
            R                S+ ++S +DL          ++  RSKSVPG       EE E
Sbjct: 302 RRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEETE 361

Query: 311 EDIDHLVK------LHRQKLARS-SMQSGSSM--------------STIGSMMSIYSEAG 349
           E ID LV        HR     S S Q+GS                +++ SMMS+YSE G
Sbjct: 362 ESIDALVSSQLSTNTHRLASGLSTSSQAGSDRKWTYLNVPDADSDTTSLNSMMSVYSETG 421

Query: 350 DFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQG 409
           D+GN+ V+G I   + Y  +T  L + VK C  LA  DE K+R++ YVK+YLLPDKSR  
Sbjct: 422 DYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNN 481

Query: 410 KRKTSIKRDTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWK 469
           KRKT I+  T NP ++ETL+Y I  + L  RTLQ SVWH+ RFGRN+FLGE EI  DSW 
Sbjct: 482 KRKTKIRTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWN 540

Query: 470 LDKKLDHCLPLHGKISAESPTGLPSHKGELVVSLKYIP-------------ASKTPVGGD 516
            +   D    L  K+      GL  +KGEL V L+YIP              +KT   G 
Sbjct: 541 FENPTDEWFVLQPKVEFAPDIGL-QYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGK 599

Query: 517 RKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNP 576
           +K+S    GG L+V+IKEAKNLTA K+GGTSDSFVKGYLLP  +KA+K KT V+KK++NP
Sbjct: 600 KKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNP 659

Query: 577 HYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDST 636
            +NHTF+++G+  +D++++CLELT+WD+E  +SN FLGGVRL  G+G+S+G+ VDWMDS 
Sbjct: 660 QWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQ 719

Query: 637 GEEVSLWQKMRQYPGSWAEGTLQLRSSMAKQKL 669
           GEE  LWQKM   PG+  EG L LRSSM K +L
Sbjct: 720 GEEQRLWQKMANNPGTPFEGVLMLRSSMGKCRL 752


>gi|46255064 synaptotagmin-like 2 isoform d [Homo sapiens]
          Length = 1256

 Score =  301 bits (771), Expect = 1e-81
 Identities = 188/535 (35%), Positives = 287/535 (53%), Gaps = 40/535 (7%)

Query: 153  GQSLLHQTQMGDIWPGRKIIQERQKEPSVLFEVPKLKSGKSALE---------------- 196
            GQ  L +   G+      + + RQ  P ++ +    K+ K  L                 
Sbjct: 727  GQGTLQEPGFGEASEAISVSRNRQPIPLLMNKENSTKTSKVELTLASPYMKQEKEEEKEG 786

Query: 197  -AESESLDSFTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKETQPGGQNVVFVDEGE 255
             +ES+  D  T+ +  + R  S  +    P  K +   +S   K      +++      +
Sbjct: 787  FSESDFSDGNTSSNAESWRNPSSSEEEPSPVLKTLE--RSAARKMPSKSLEDISSDSSNQ 844

Query: 256  MIFKKNTRKILRPSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGLNVDMEEEEEEEDI-D 314
                    +++R +E   S +  +P++       L   SKSVP    D  ++ E +   +
Sbjct: 845  AKVDNQPEELVRSAEDV-STVPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDTASE 903

Query: 315  HLVKLHRQKLARSSMQSGSSMSTI-------GSMMSIYSEAGDFGNIFVTGRIAFSLKYE 367
               +L R K + SS+ + SS S +       GS+MS+YS  GDFGN+ V G I F+++Y 
Sbjct: 904  SSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYS--GDFGNLEVKGNIQFAIEYV 961

Query: 368  QQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDET 427
            +  + L V V +C  LA AD  K+RS+PYVK YLLPDK + GK+KT + + T+NP+Y+E 
Sbjct: 962  ESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEI 1021

Query: 428  LRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAE 487
            LRY+I + +L  + L  S+WH   F RN+FLGE E+ +++W  D K +  L  +      
Sbjct: 1022 LRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKT 1081

Query: 488  SPTGLPS-HKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGT 546
            +P  L + ++GE+ ++L+Y+P    PV G +  +     GE+ +W+KE  +L   + G  
Sbjct: 1082 APVALEAENRGEMKLALQYVP---EPVPGKKLPTT----GEVHIWVKECLDLPLLR-GSH 1133

Query: 547  SDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREP 606
             +SFVK  +LP  ++ S++KT  + KT NP +NHT VY+G R EDL   C+ELTVWD   
Sbjct: 1134 LNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYK 1193

Query: 607  LASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQLR 661
            L +N FLGG+R+G GTG S G  VDWMDST EEV+LW+KM   P +W E TL LR
Sbjct: 1194 L-TNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR 1247


>gi|46255062 synaptotagmin-like 2 isoform c [Homo sapiens]
          Length = 1272

 Score =  298 bits (764), Expect = 8e-81
 Identities = 189/538 (35%), Positives = 284/538 (52%), Gaps = 23/538 (4%)

Query: 133  SEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPSVLFEVPKLKSGK 192
            SE I +S   +P          +   + ++    P  K  +E +KE    F       G 
Sbjct: 740  SEAISVSRNRQPIPLLMNKENSTKTSKVELTLASPYMKQEKEEEKEG---FSESDFSDGN 796

Query: 193  SALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKETQPGGQNVVFVD 252
            ++  AES    S + +  S   +     +      K +    S    + +   Q    V 
Sbjct: 797  TSSNAESWRNPSSSEEEPSPVLKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVR 856

Query: 253  EGEMIFKKNTRKILRPSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGLNVDMEEEEEEED 312
              E   K + + +        S +  +P++       L   SKSVP    D  ++ E + 
Sbjct: 857  SAEDDEKPDQKPVTNECVPRISTVPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDT 916

Query: 313  I-DHLVKLHRQKLARSSMQSGSSMSTI-------GSMMSIYSEAGDFGNIFVTGRIAFSL 364
              +   +L R K + SS+ + SS S +       GS+MS+YS  GDFGN+ V G I F++
Sbjct: 917  ASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYS--GDFGNLEVKGNIQFAI 974

Query: 365  KYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLY 424
            +Y +  + L V V +C  LA AD  K+RS+PYVK YLLPDK + GK+KT + + T+NP+Y
Sbjct: 975  EYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVY 1034

Query: 425  DETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKI 484
            +E LRY+I + +L  + L  S+WH   F RN+FLGE E+ +++W  D K +  L  +   
Sbjct: 1035 NEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLK 1094

Query: 485  SAESPTGLPS-HKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKA 543
               +P  L + ++GE+ ++L+Y+P    PV G +  +     GE+ +W+KE  +L   + 
Sbjct: 1095 RKTAPVALEAENRGEMKLALQYVP---EPVPGKKLPTT----GEVHIWVKECLDLPLLR- 1146

Query: 544  GGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWD 603
            G   +SFVK  +LP  ++ S++KT  + KT NP +NHT VY+G R EDL   C+ELTVWD
Sbjct: 1147 GSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWD 1206

Query: 604  REPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQLR 661
               L +N FLGG+R+G GTG S G  VDWMDST EEV+LW+KM   P +W E TL LR
Sbjct: 1207 HYKL-TNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR 1263


>gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens]
          Length = 935

 Score =  298 bits (762), Expect = 1e-80
 Identities = 169/409 (41%), Positives = 246/409 (60%), Gaps = 25/409 (6%)

Query: 267 RPSEYTKSVIDL-----RPEDVVHESGSLGDRSKSVPGLNVDMEEEEEEEDI-DHLVKLH 320
           +P E  +S  D+     +P++       L   SKSVP    D  ++ E +   +   +L 
Sbjct: 529 QPEELVRSAEDVSTVPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDTASESSYQLS 588

Query: 321 RQKLARSSMQSGSSMSTI-------GSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQTQSL 373
           R K + SS+ + SS S +       GS+MS+YS  GDFGN+ V G I F+++Y +  + L
Sbjct: 589 RHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYS--GDFGNLEVKGNIQFAIEYVESLKEL 646

Query: 374 VVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYEIP 433
            V V +C  LA AD  K+RS+PYVK YLLPDK + GK+KT + + T+NP+Y+E LRY+I 
Sbjct: 647 HVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIE 706

Query: 434 ESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPTGLP 493
           + +L  + L  S+WH   F RN+FLGE E+ +++W  D K +  L  +      +P  L 
Sbjct: 707 KQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALE 766

Query: 494 S-HKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVK 552
           + ++GE+ ++L+Y+P    PV G +  +     GE+ +W+KE  +L   + G   +SFVK
Sbjct: 767 AENRGEMKLALQYVP---EPVPGKKLPTT----GEVHIWVKECLDLPLLR-GSHLNSFVK 818

Query: 553 GYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDF 612
             +LP  ++ S++KT  + KT NP +NHT VY+G R EDL   C+ELTVWD   L +N F
Sbjct: 819 CTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQF 877

Query: 613 LGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQLR 661
           LGG+R+G GTG S G  VDWMDST EEV+LW+KM   P +W E TL LR
Sbjct: 878 LGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR 926



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 53/244 (21%), Positives = 101/244 (41%), Gaps = 17/244 (6%)

Query: 4   LLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTC 63
           ++DLSFL+EEE++ I+ VLQRD  +++A+E+R+R L  ++ + ++     G   Y  +  
Sbjct: 1   MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEAKAK 60

Query: 64  ARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFYDQK 123
               +  G    + +  +    +     + +E+         AKE  +     D F   +
Sbjct: 61  RHRDKIHGADIIRASMRKKRPQIAAEQSKDRENG--------AKESWVNNVNKDAFLPPE 112

Query: 124 VNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPSVLF 183
           +         +    S      V+   +V       T+  ++ P     ++++K P   F
Sbjct: 113 LAGVVEEPEEDAAPAS-PSSSVVNPASSVIDMSQENTRKPNVSP-----EKQRKNP---F 163

Query: 184 EVPKLKSGKSALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKETQP 243
              KL  G S+ + ++E   +       TS+ D L +S         S  K +  K+T P
Sbjct: 164 NSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLEKSKQTLP 223

Query: 244 GGQN 247
           G  N
Sbjct: 224 GLSN 227


>gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens]
          Length = 934

 Score =  298 bits (762), Expect = 1e-80
 Identities = 169/409 (41%), Positives = 246/409 (60%), Gaps = 25/409 (6%)

Query: 267 RPSEYTKSVIDL-----RPEDVVHESGSLGDRSKSVPGLNVDMEEEEEEEDI-DHLVKLH 320
           +P E  +S  D+     +P++       L   SKSVP    D  ++ E +   +   +L 
Sbjct: 528 QPEELVRSAEDVSTVPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDTASESSYQLS 587

Query: 321 RQKLARSSMQSGSSMSTI-------GSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQTQSL 373
           R K + SS+ + SS S +       GS+MS+YS  GDFGN+ V G I F+++Y +  + L
Sbjct: 588 RHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYS--GDFGNLEVKGNIQFAIEYVESLKEL 645

Query: 374 VVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYEIP 433
            V V +C  LA AD  K+RS+PYVK YLLPDK + GK+KT + + T+NP+Y+E LRY+I 
Sbjct: 646 HVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIE 705

Query: 434 ESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPTGLP 493
           + +L  + L  S+WH   F RN+FLGE E+ +++W  D K +  L  +      +P  L 
Sbjct: 706 KQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALE 765

Query: 494 S-HKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVK 552
           + ++GE+ ++L+Y+P    PV G +  +     GE+ +W+KE  +L   + G   +SFVK
Sbjct: 766 AENRGEMKLALQYVP---EPVPGKKLPTT----GEVHIWVKECLDLPLLR-GSHLNSFVK 817

Query: 553 GYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDF 612
             +LP  ++ S++KT  + KT NP +NHT VY+G R EDL   C+ELTVWD   L +N F
Sbjct: 818 CTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQF 876

Query: 613 LGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQLR 661
           LGG+R+G GTG S G  VDWMDST EEV+LW+KM   P +W E TL LR
Sbjct: 877 LGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR 925



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 54/244 (22%), Positives = 100/244 (40%), Gaps = 18/244 (7%)

Query: 4   LLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTC 63
           ++DLSFL+EEE++ I+ VLQRD  +++A+E+R+R L  ++ + ++     G   Y  +  
Sbjct: 1   MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEAKAK 60

Query: 64  ARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFYDQK 123
               +  G    + +  +    +     + +E+         AKE  +     D F   +
Sbjct: 61  RHRDKIHGADIIRASMRKKRPQIAAEQSKDRENG--------AKESWVNNVNKDAFLPPE 112

Query: 124 VNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPSVLF 183
           +         +    S      V+   +V       T+  ++ P      E++K P   F
Sbjct: 113 LAGVVEEPEEDAAPAS-PSSSVVNPASSVIDMSQENTRKPNVSP------EKRKNP---F 162

Query: 184 EVPKLKSGKSALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKETQP 243
              KL  G S+ + ++E   +       TS+ D L +S         S  K +  K+T P
Sbjct: 163 NSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLEKSKQTLP 222

Query: 244 GGQN 247
           G  N
Sbjct: 223 GLSN 226


>gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens]
          Length = 376

 Score =  294 bits (752), Expect = 2e-79
 Identities = 163/377 (43%), Positives = 234/377 (62%), Gaps = 20/377 (5%)

Query: 294 SKSVPGLNVDMEEEEEEEDI-DHLVKLHRQKLARSSMQSGSSMSTI-------GSMMSIY 345
           SKSVP    D  ++ E +   +   +L R K + SS+ + SS S +       GS+MS+Y
Sbjct: 2   SKSVPAFLQDESDDRETDTASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVY 61

Query: 346 SEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDK 405
           S  GDFGN+ V G I F+++Y +  + L V V +C  LA AD  K+RS+PYVK YLLPDK
Sbjct: 62  S--GDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDK 119

Query: 406 SRQGKRKTSIKRDTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQM 465
            + GK+KT + + T+NP+Y+E LRY+I + +L  + L  S+WH   F RN+FLGE E+ +
Sbjct: 120 GKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDL 179

Query: 466 DSWKLDKKLDHCLPLHGKISAESPTGLPS-HKGELVVSLKYIPASKTPVGGDRKKSKGGE 524
           ++W  D K +  L  +      +P  L + ++GE+ ++L+Y+P    PV G +  +    
Sbjct: 180 ETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVP---EPVPGKKLPTT--- 233

Query: 525 GGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVY 584
            GE+ +W+KE  +L   + G   +SFVK  +LP  ++ S++KT  + KT NP +NHT VY
Sbjct: 234 -GEVHIWVKECLDLPLLR-GSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVY 291

Query: 585 NGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQ 644
           +G R EDL   C+ELTVWD   L +N FLGG+R+G GTG S G  VDWMDST EEV+LW+
Sbjct: 292 DGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWE 350

Query: 645 KMRQYPGSWAEGTLQLR 661
           KM   P +W E TL LR
Sbjct: 351 KMVNSPNTWIEATLPLR 367


>gi|46255066 synaptotagmin-like 2 isoform e [Homo sapiens]
          Length = 376

 Score =  294 bits (752), Expect = 2e-79
 Identities = 163/377 (43%), Positives = 234/377 (62%), Gaps = 20/377 (5%)

Query: 294 SKSVPGLNVDMEEEEEEEDI-DHLVKLHRQKLARSSMQSGSSMSTI-------GSMMSIY 345
           SKSVP    D  ++ E +   +   +L R K + SS+ + SS S +       GS+MS+Y
Sbjct: 2   SKSVPAFLQDESDDRETDTASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVY 61

Query: 346 SEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDK 405
           S  GDFGN+ V G I F+++Y +  + L V V +C  LA AD  K+RS+PYVK YLLPDK
Sbjct: 62  S--GDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDK 119

Query: 406 SRQGKRKTSIKRDTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQM 465
            + GK+KT + + T+NP+Y+E LRY+I + +L  + L  S+WH   F RN+FLGE E+ +
Sbjct: 120 GKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDL 179

Query: 466 DSWKLDKKLDHCLPLHGKISAESPTGLPS-HKGELVVSLKYIPASKTPVGGDRKKSKGGE 524
           ++W  D K +  L  +      +P  L + ++GE+ ++L+Y+P    PV G +  +    
Sbjct: 180 ETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVP---EPVPGKKLPTT--- 233

Query: 525 GGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVY 584
            GE+ +W+KE  +L   + G   +SFVK  +LP  ++ S++KT  + KT NP +NHT VY
Sbjct: 234 -GEVHIWVKECLDLPLLR-GSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVY 291

Query: 585 NGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQ 644
           +G R EDL   C+ELTVWD   L +N FLGG+R+G GTG S G  VDWMDST EEV+LW+
Sbjct: 292 DGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWE 350

Query: 645 KMRQYPGSWAEGTLQLR 661
           KM   P +W E TL LR
Sbjct: 351 KMVNSPNTWIEATLPLR 367


>gi|46255068 synaptotagmin-like 2 isoform f [Homo sapiens]
          Length = 365

 Score =  289 bits (739), Expect = 7e-78
 Identities = 155/364 (42%), Positives = 227/364 (62%), Gaps = 16/364 (4%)

Query: 303 DMEEEEEEEDIDHLVKLHRQKLARSSMQSGSSMSTI----GSMMSIYSEAGDFGNIFVTG 358
           D E +   E    L +  +   + +++ S S M+++    GS+MS+YS  GDFGN+ V G
Sbjct: 4   DRETDTASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYS--GDFGNLEVKG 61

Query: 359 RIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRD 418
            I F+++Y +  + L V V +C  LA AD  K+RS+PYVK YLLPDK + GK+KT + + 
Sbjct: 62  NIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKK 121

Query: 419 TINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCL 478
           T+NP+Y+E LRY+I + +L  + L  S+WH   F RN+FLGE E+ +++W  D K +  L
Sbjct: 122 TLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQL 181

Query: 479 PLHGKISAESPTGLPS-HKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKN 537
             +      +P  L + ++GE+ ++L+Y+P    PV G +  +     GE+ +W+KE  +
Sbjct: 182 RWYPLKRKTAPVALEAENRGEMKLALQYVP---EPVPGKKLPTT----GEVHIWVKECLD 234

Query: 538 LTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCL 597
           L   + G   +SFVK  +LP  ++ S++KT  + KT NP +NHT VY+G R EDL   C+
Sbjct: 235 LPLLR-GSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACV 293

Query: 598 ELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGT 657
           ELTVWD   L +N FLGG+R+G GTG S G  VDWMDST EEV+LW+KM   P +W E T
Sbjct: 294 ELTVWDHYKL-TNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEAT 352

Query: 658 LQLR 661
           L LR
Sbjct: 353 LPLR 356


>gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens]
          Length = 910

 Score =  285 bits (729), Expect = 1e-76
 Identities = 153/345 (44%), Positives = 217/345 (62%), Gaps = 14/345 (4%)

Query: 320 HRQKLARSSMQSGSSMS--TIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHV 377
           H  KL R S    + +     GS+MS+YS  GDFGN+ V G I F+++Y +  + L V V
Sbjct: 568 HPDKLKRMSKSVPAFLQDEVSGSVMSVYS--GDFGNLEVKGNIQFAIEYVESLKELHVFV 625

Query: 378 KECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYEIPESLL 437
            +C  LA AD  K+RS+PYVK YLLPDK + GK+KT + + T+NP+Y+E LRY+I + +L
Sbjct: 626 AQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQIL 685

Query: 438 AQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPTGLPS-HK 496
             + L  S+WH   F RN+FLGE E+ +++W  D K +  L  +      +P  L + ++
Sbjct: 686 KTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENR 745

Query: 497 GELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLL 556
           GE+ ++L+Y+P    PV G +  +     GE+ +W+KE  +L   + G   +SFVK  +L
Sbjct: 746 GEMKLALQYVP---EPVPGKKLPTT----GEVHIWVKECLDLPLLR-GSHLNSFVKCTIL 797

Query: 557 PMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGV 616
           P  ++ S++KT  + KT NP +NHT VY+G R EDL   C+ELTVWD   L +N FLGG+
Sbjct: 798 PDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGL 856

Query: 617 RLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQLR 661
           R+G GTG S G  VDWMDST EEV+LW+KM   P +W E TL LR
Sbjct: 857 RIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR 901



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 54/244 (22%), Positives = 100/244 (40%), Gaps = 18/244 (7%)

Query: 4   LLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTC 63
           ++DLSFL+EEE++ I+ VLQRD  +++A+E+R+R L  ++ + ++     G   Y  +  
Sbjct: 1   MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEAKAK 60

Query: 64  ARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFYDQK 123
               +  G    + +  +    +     + +E+         AKE  +     D F   +
Sbjct: 61  RHRDKIHGADIIRASMRKKRPQIAAEQSKDRENG--------AKESWVNNVNKDAFLPPE 112

Query: 124 VNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPSVLF 183
           +         +    S      V+   +V       T+  ++ P      E++K P   F
Sbjct: 113 LAGVVEEPEEDAAPAS-PSSSVVNPASSVIDMSQENTRKPNVSP------EKRKNP---F 162

Query: 184 EVPKLKSGKSALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKETQP 243
              KL  G S+ + ++E   +       TS+ D L +S         S  K +  K+T P
Sbjct: 163 NSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLEKSKQTLP 222

Query: 244 GGQN 247
           G  N
Sbjct: 223 GLSN 226


>gi|244790016 synaptotagmin-like 2 isoform h [Homo sapiens]
          Length = 336

 Score =  284 bits (726), Expect = 2e-76
 Identities = 148/324 (45%), Positives = 210/324 (64%), Gaps = 12/324 (3%)

Query: 339 GSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVK 398
           GS+MS+YS  GDFGN+ V G I F+++Y +  + L V V +C  LA AD  K+RS+PYVK
Sbjct: 15  GSVMSVYS--GDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVK 72

Query: 399 TYLLPDKSRQGKRKTSIKRDTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFL 458
            YLLPDK + GK+KT + + T+NP+Y+E LRY+I + +L  + L  S+WH   F RN+FL
Sbjct: 73  AYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFL 132

Query: 459 GEAEIQMDSWKLDKKLDHCLPLHGKISAESPTGLPS-HKGELVVSLKYIPASKTPVGGDR 517
           GE E+ +++W  D K +  L  +      +P  L + ++GE+ ++L+Y+P    PV G +
Sbjct: 133 GEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVP---EPVPGKK 189

Query: 518 KKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPH 577
             +     GE+ +W+KE  +L   + G   +SFVK  +LP  ++ S++KT  + KT NP 
Sbjct: 190 LPTT----GEVHIWVKECLDLPLLR-GSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPI 244

Query: 578 YNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTG 637
           +NHT VY+G R EDL   C+ELTVWD   L +N FLGG+R+G GTG S G  VDWMDST 
Sbjct: 245 FNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTGKSYGTEVDWMDSTS 303

Query: 638 EEVSLWQKMRQYPGSWAEGTLQLR 661
           EEV+LW+KM   P +W E TL LR
Sbjct: 304 EEVALWEKMVNSPNTWIEATLPLR 327


>gi|14249614 synaptotagmin-like 1 [Homo sapiens]
          Length = 550

 Score =  263 bits (671), Expect = 5e-70
 Identities = 188/558 (33%), Positives = 286/558 (51%), Gaps = 87/558 (15%)

Query: 110 ELKKATGDWFYDQKVNRFAY-RTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPG 168
           +LK  TGDWF + +  R      GS+++R S+R K               ++  GD  PG
Sbjct: 75  QLKILTGDWFQEARSQRHHNAHFGSDLVRASMRRK---------------KSTRGDQAPG 119

Query: 169 RKIIQERQKEPSVLFEVPKLKSGKSALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWK 228
                +R+ E +V  +    +   +  EA  E L   T  SD      + +  G   +  
Sbjct: 120 H----DREAEAAVKEKEEGPEPRLTIDEAPQERLRE-TEASDPEEASQAQEDPGQGDQ-- 172

Query: 229 KMSAPKSQVEKETQPGGQNVVFVDEGEMIFKKNTRKILRPSEYTKSVIDLRPEDVVHESG 288
           ++ A ++  E E   GG+                              + RP+    ++ 
Sbjct: 173 QVCAEEADPELEPASGGEQ-----------------------------EPRPQQAQTKAA 203

Query: 289 S-LGDRSKSVPGLNVDMEEEEEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSE 347
           S + +  +  PG +  ++               R   + SS+ S +S +  GS MS+   
Sbjct: 204 SQILENGEEAPGPDPSLD---------------RMLSSSSSVSSLNSSTLSGSQMSL--- 245

Query: 348 AGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSR 407
           +GD   + V G + F+L YE     L VHV +C  LA A   ++RS+PYVK+YLLPDK  
Sbjct: 246 SGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAA--RRRRSDPYVKSYLLPDK-- 301

Query: 408 QGKRKTSIKRDTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDS 467
           Q KRKT++K+  +NP+++ETLRY +P++ L  R L  SVWH    GRN FLGE E+ +D+
Sbjct: 302 QSKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDT 361

Query: 468 WKLDKKLDHCLPLHGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGE 527
           W    +    LPL  ++   SP  LPS +G L +SLKY+PA     G           GE
Sbjct: 362 WDWGSE-PTWLPLQPRV-PPSPDDLPS-RGLLALSLKYVPAGSEGAGLP-------PSGE 411

Query: 528 LQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGV 587
           L  W+KEA++L   +A G+ D++V+ ++LP  ++AS+++T V++++L+P +NHT VY+G 
Sbjct: 412 LHFWVKEARDLLPLRA-GSLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGF 470

Query: 588 RLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMR 647
              DL+  C EL++WD   LA N  LGG RL +GTG S G  V WMDST EE  LWQ + 
Sbjct: 471 GPADLRQACAELSLWDHGALA-NRQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQALL 529

Query: 648 QYPGSWAEGTLQLRSSMA 665
           + P  W +G L LR+++A
Sbjct: 530 EQPCEWVDGLLPLRTNLA 547



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 20/37 (54%), Positives = 29/37 (78%)

Query: 4  LLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLK 40
          LLDLSFL+EEE++ I  VLQRD  +R+ +E R+ +L+
Sbjct: 31 LLDLSFLTEEEQEAIAGVLQRDARLRQLEEGRVSKLR 67


>gi|110227631 synaptotagmin-like 3 [Homo sapiens]
          Length = 542

 Score =  213 bits (543), Expect = 4e-55
 Identities = 141/389 (36%), Positives = 203/389 (52%), Gaps = 40/389 (10%)

Query: 293 RSKSVPGLNVDMEEEEEEEDIDHLVKLHRQKLARSSMQSGSSMSTI-------GSMMSIY 345
           R  S P +   + +E+ +   + ++K       + ++ S  + STI       GS++SI 
Sbjct: 172 RKVSAPDILKPLNQEDPKCSTNPILK-------QQNLPSSPAPSTIFSGGFRHGSLISID 224

Query: 346 S---EAGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLL 402
           S   E G+F N  VTG I F++ Y  +T SL + +K C  LAY +E KK+ NPYVKTYLL
Sbjct: 225 STCTEMGNFDNANVTGEIEFAIHYCFKTHSLEICIKACKNLAYGEEKKKKCNPYVKTYLL 284

Query: 403 PDKSRQGKRKTSIKRDTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAE 462
           PD+S QGKRKT ++R+T++P + ETL+Y++  + L  R LQ SVWH G   R  FLGE  
Sbjct: 285 PDRSSQGKRKTGVQRNTVDPTFQETLKYQVAPAQLVTRQLQVSVWHLGTLARRVFLGEVI 344

Query: 463 IQMDSWKLDKKLDHCL---PLHGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKK 519
           I + +W  +          PL  K + +    +P   GEL V  K +  S+      RK 
Sbjct: 345 IPLATWDFEDSTTQSFRWHPLRAK-AEKYEDSVPQSNGELTVRAKLVLPSR-----PRKL 398

Query: 520 SKGGEG-------GELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKK 572
            +  EG       G+L + +  AKNL   +  GT +SFVKG L     +  + K+PV++K
Sbjct: 399 QEAQEGTDQPSLHGQLCLVVLGAKNL-PVRPDGTLNSFVKGCLTLPDQQKLRLKSPVLRK 457

Query: 573 TLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASND-FLGGVRLGVGTGISNGEVVD 631
              P + H+FV++GV    L+   LELTVWD+     ND  LGG RLG     S G+   
Sbjct: 458 QACPQWKHSFVFSGVTPAQLRQSSLELTVWDQALFGMNDRLLGGTRLG-----SKGDTAV 512

Query: 632 WMDSTGEEVSLWQKMRQYPGSWAEGTLQL 660
             D+       WQK+   P  W + TL L
Sbjct: 513 GGDACSLSKLQWQKVLSSPNLWTDMTLVL 541



 Score =  119 bits (299), Expect = 7e-27
 Identities = 61/162 (37%), Positives = 89/162 (54%), Gaps = 17/162 (10%)

Query: 1   MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSD 60
           M++ +DLS L E E++ IL VL RD+ V+  +E+R R+LK  L  ++ KGAK     + +
Sbjct: 1   MAQEIDLSALKELEREAILQVLYRDQAVQNTEEERTRKLKTHLQHLRWKGAKNTDWEHKE 60

Query: 61  RTCARCQESLGRLSPKTNTCRGCNHLVCRDCRI-QESNGTWRCKVCAKEIELKKATGDWF 119
           + CARCQ+ LG L  +   CRGC+H VC  CR+       W+C VC ++  +K  TG+WF
Sbjct: 61  KCCARCQQVLGFLLHRGAVCRGCSHRVCAQCRVFLRGTHAWKCTVCFEDRNVKIKTGEWF 120

Query: 120 YDQKVNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQ 161
           Y+++  +F                P   K ETVG  LL   Q
Sbjct: 121 YEERAKKF----------------PTGGKHETVGGQLLQSYQ 146


>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
          Length = 694

 Score =  173 bits (438), Expect = 5e-43
 Identities = 170/668 (25%), Positives = 275/668 (41%), Gaps = 116/668 (17%)

Query: 10  LSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQES 69
           L++EEK++I  V+ R E++ + +++RI RL + L  +++  A  G        C  C E 
Sbjct: 50  LTDEEKEIINRVIARAEKMEEMEQERIGRLVDRLENMRKNVAGDGVNR-----CILCGEQ 104

Query: 70  LGRLSPKTNTCRGCNHLVCRDCRIQESN---GTWRCKVCAKEIELKKATGDWFY------ 120
           LG L      C  C   VC  C ++ +N     W CK+C ++ E+ K +G WF+      
Sbjct: 105 LGMLGSACVVCEDCKKNVCTKCGVETNNRLHSVWLCKICIEQREVWKRSGAWFFKGFPKQ 164

Query: 121 --DQKVNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKE 178
              Q +     +    +   +   +PA   +          ++     PG+K   +    
Sbjct: 165 VLPQPMPIKKTKPQQPVSEPAAPEQPAPEPKHPARAPARGDSE-DRRGPGQKTGPDPASA 223

Query: 179 PSVLFEVPKLKSGK----SALEAESESLDSFTADSDST------SRRDSLDKSGLFPEWK 228
           P      P ++       S+   +SES D      DS+       R +S+  S   P   
Sbjct: 224 PGRGNYGPPVRRASEARMSSSSRDSESWDHSGGAGDSSRSPAGLRRANSVQASRPAPGSV 283

Query: 229 KMSAPKSQVEKETQPGGQNV------VFVDEGEMIFKKNTRKILRPSEYTKS------VI 276
           +  AP    +  T PGG          F D+   +   +      P E           +
Sbjct: 284 QSPAPPQPGQPGT-PGGSRPGPGPAGRFPDQKPEVAPSDPGTTAPPREERTGGVGGYPAV 342

Query: 277 DLRPEDVVHESGSLGDRSKSVP----GLNVDMEEEEEEEDIDHLVKLHRQKLARSSMQSG 332
             R + + H SG     S + P           EEEEEE               ++    
Sbjct: 343 GAREDRMSHPSGPYSQASAAAPQPAAARQPPPPEEEEEE---------------ANSYDS 387

Query: 333 SSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKR 392
              +T+G+                   + FSL Y+Q   SL   + +   L   D +   
Sbjct: 388 DEATTLGA-------------------LEFSLLYDQDNSSLQCTIIKAKGLKPMD-SNGL 427

Query: 393 SNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYE-IPESLLAQRTLQFSVWHHGR 451
           ++PYVK +LLP  S+  K +T   R+T NP+++ETL Y  I +  + ++TL+ SV    +
Sbjct: 428 ADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDK 487

Query: 452 FGRNTFLGEAEIQMDSWKLDKK------LDHCLPLHGKISAESPTGLP------------ 493
           FG N F+GE    +   K +++      L+  +P+    +  S  G+             
Sbjct: 488 FGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGD 547

Query: 494 -SHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVK 552
              +G+++VSL Y     T  GG            L V I    +L A  A G SD FVK
Sbjct: 548 IEERGKILVSLMY----STQQGG------------LIVGIIRCVHLAAMDANGYSDPFVK 591

Query: 553 GYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDF 612
            +L P   K +K KT + KKTLNP +N  F Y+ ++  DL    L+++VWD +   SND+
Sbjct: 592 LWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYD-IKHSDLAKKSLDISVWDYDIGKSNDY 650

Query: 613 LGGVRLGV 620
           +GG +LG+
Sbjct: 651 IGGCQLGI 658


>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
          Length = 690

 Score =  173 bits (438), Expect = 5e-43
 Identities = 170/668 (25%), Positives = 275/668 (41%), Gaps = 116/668 (17%)

Query: 10  LSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQES 69
           L++EEK++I  V+ R E++ + +++RI RL + L  +++  A  G        C  C E 
Sbjct: 46  LTDEEKEIINRVIARAEKMEEMEQERIGRLVDRLENMRKNVAGDGVNR-----CILCGEQ 100

Query: 70  LGRLSPKTNTCRGCNHLVCRDCRIQESN---GTWRCKVCAKEIELKKATGDWFY------ 120
           LG L      C  C   VC  C ++ +N     W CK+C ++ E+ K +G WF+      
Sbjct: 101 LGMLGSACVVCEDCKKNVCTKCGVETNNRLHSVWLCKICIEQREVWKRSGAWFFKGFPKQ 160

Query: 121 --DQKVNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKE 178
              Q +     +    +   +   +PA   +          ++     PG+K   +    
Sbjct: 161 VLPQPMPIKKTKPQQPVSEPAAPEQPAPEPKHPARAPARGDSE-DRRGPGQKTGPDPASA 219

Query: 179 PSVLFEVPKLKSGK----SALEAESESLDSFTADSDST------SRRDSLDKSGLFPEWK 228
           P      P ++       S+   +SES D      DS+       R +S+  S   P   
Sbjct: 220 PGRGNYGPPVRRASEARMSSSSRDSESWDHSGGAGDSSRSPAGLRRANSVQASRPAPGSV 279

Query: 229 KMSAPKSQVEKETQPGGQNV------VFVDEGEMIFKKNTRKILRPSEYTKS------VI 276
           +  AP    +  T PGG          F D+   +   +      P E           +
Sbjct: 280 QSPAPPQPGQPGT-PGGSRPGPGPAGRFPDQKPEVAPSDPGTTAPPREERTGGVGGYPAV 338

Query: 277 DLRPEDVVHESGSLGDRSKSVP----GLNVDMEEEEEEEDIDHLVKLHRQKLARSSMQSG 332
             R + + H SG     S + P           EEEEEE               ++    
Sbjct: 339 GAREDRMSHPSGPYSQASAAAPQPAAARQPPPPEEEEEE---------------ANSYDS 383

Query: 333 SSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKR 392
              +T+G+                   + FSL Y+Q   SL   + +   L   D +   
Sbjct: 384 DEATTLGA-------------------LEFSLLYDQDNSSLQCTIIKAKGLKPMD-SNGL 423

Query: 393 SNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYE-IPESLLAQRTLQFSVWHHGR 451
           ++PYVK +LLP  S+  K +T   R+T NP+++ETL Y  I +  + ++TL+ SV    +
Sbjct: 424 ADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDK 483

Query: 452 FGRNTFLGEAEIQMDSWKLDKK------LDHCLPLHGKISAESPTGLP------------ 493
           FG N F+GE    +   K +++      L+  +P+    +  S  G+             
Sbjct: 484 FGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGD 543

Query: 494 -SHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVK 552
              +G+++VSL Y     T  GG            L V I    +L A  A G SD FVK
Sbjct: 544 IEERGKILVSLMY----STQQGG------------LIVGIIRCVHLAAMDANGYSDPFVK 587

Query: 553 GYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDF 612
            +L P   K +K KT + KKTLNP +N  F Y+ ++  DL    L+++VWD +   SND+
Sbjct: 588 LWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYD-IKHSDLAKKSLDISVWDYDIGKSNDY 646

Query: 613 LGGVRLGV 620
           +GG +LG+
Sbjct: 647 IGGCQLGI 654


>gi|211059429 synaptotagmin II [Homo sapiens]
          Length = 419

 Score =  146 bits (368), Expect = 7e-35
 Identities = 89/277 (32%), Positives = 147/277 (53%), Gaps = 27/277 (9%)

Query: 358 GRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKR 417
           G++ FSL Y+ Q   L V V +  +L   D     S+PYVK +LLPDK +  K +T + R
Sbjct: 141 GKLQFSLDYDFQANQLTVGVLQAAELPALDMGGT-SDPYVKVFLLPDKKK--KYETKVHR 197

Query: 418 DTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHC 477
            T+NP ++ET  +++P   L  +TL  +++   RF ++  +GE ++ M++  L + ++  
Sbjct: 198 KTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEW 257

Query: 478 LPLHGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKN 537
             L G    E     P   G++  SL+Y+P +                G+L V I EAKN
Sbjct: 258 RDLQGGEKEE-----PEKLGDICTSLRYVPTA----------------GKLTVCILEAKN 296

Query: 538 LTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCL 597
           L     GG SD +VK +L+    +  K+KT V KKTLNP++N +F +  +  E +Q + +
Sbjct: 297 LKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFE-IPFEQIQKVQV 355

Query: 598 ELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMD 634
            +TV D + L  N+ +G  ++ VG+  +  E+  W D
Sbjct: 356 VVTVLDYDKLGKNEAIG--KIFVGSNATGTELRHWSD 390



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 39/116 (33%), Positives = 64/116 (55%), Gaps = 3/116 (2%)

Query: 524 EGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFV 583
           +  +L V + +A  L A   GGTSD +VK +LLP  +K  K +T V +KTLNP +N TF 
Sbjct: 152 QANQLTVGVLQAAELPALDMGGTSDPYVKVFLLP--DKKKKYETKVHRKTLNPAFNETFT 209

Query: 584 YNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEE 639
           +  V  ++L    L + ++D +  + +D +G V++ + T      + +W D  G E
Sbjct: 210 FK-VPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGE 264


>gi|31543670 synaptotagmin II [Homo sapiens]
          Length = 419

 Score =  146 bits (368), Expect = 7e-35
 Identities = 89/277 (32%), Positives = 147/277 (53%), Gaps = 27/277 (9%)

Query: 358 GRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKR 417
           G++ FSL Y+ Q   L V V +  +L   D     S+PYVK +LLPDK +  K +T + R
Sbjct: 141 GKLQFSLDYDFQANQLTVGVLQAAELPALDMGGT-SDPYVKVFLLPDKKK--KYETKVHR 197

Query: 418 DTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHC 477
            T+NP ++ET  +++P   L  +TL  +++   RF ++  +GE ++ M++  L + ++  
Sbjct: 198 KTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEW 257

Query: 478 LPLHGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKN 537
             L G    E     P   G++  SL+Y+P +                G+L V I EAKN
Sbjct: 258 RDLQGGEKEE-----PEKLGDICTSLRYVPTA----------------GKLTVCILEAKN 296

Query: 538 LTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCL 597
           L     GG SD +VK +L+    +  K+KT V KKTLNP++N +F +  +  E +Q + +
Sbjct: 297 LKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFE-IPFEQIQKVQV 355

Query: 598 ELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMD 634
            +TV D + L  N+ +G  ++ VG+  +  E+  W D
Sbjct: 356 VVTVLDYDKLGKNEAIG--KIFVGSNATGTELRHWSD 390



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 39/116 (33%), Positives = 64/116 (55%), Gaps = 3/116 (2%)

Query: 524 EGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFV 583
           +  +L V + +A  L A   GGTSD +VK +LLP  +K  K +T V +KTLNP +N TF 
Sbjct: 152 QANQLTVGVLQAAELPALDMGGTSDPYVKVFLLP--DKKKKYETKVHRKTLNPAFNETFT 209

Query: 584 YNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEE 639
           +  V  ++L    L + ++D +  + +D +G V++ + T      + +W D  G E
Sbjct: 210 FK-VPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGE 264


>gi|92859638 synaptotagmin V [Homo sapiens]
          Length = 386

 Score =  143 bits (360), Expect = 6e-34
 Identities = 94/291 (32%), Positives = 145/291 (49%), Gaps = 26/291 (8%)

Query: 358 GRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKR 417
           GR+ +SL Y+ Q+  L+V + +   LA  D     S+PYV+ YLLPDK R  + +T + R
Sbjct: 110 GRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGS-SDPYVRVYLLPDKRR--RYETKVHR 166

Query: 418 DTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHC 477
            T+NP + ET  +++P   L  R L  +V+   RF RN  +GE  + M S  L + +   
Sbjct: 167 QTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAW 226

Query: 478 LPLHGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKN 537
             L       +P       G++  SL+Y+P +                G+L V + EAKN
Sbjct: 227 RELQA-----APREEQEKLGDICFSLRYVPTA----------------GKLTVIVLEAKN 265

Query: 538 LTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCL 597
           L     GG SD +VK +LL    K  K+KT + K TLNP+YN  F +  V  + +Q + +
Sbjct: 266 LKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFE-VPCDQVQKVQV 324

Query: 598 ELTVWDREPLASNDFLGGVRLGVGTGISN-GEVVDWMDSTGEEVSLWQKMR 647
           ELTV D + L  N+ +G V +G   G +      D + +    ++ W  +R
Sbjct: 325 ELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRHWADMLANPRRPIAQWHSLR 375


>gi|6005997 double C2-like domains, beta [Homo sapiens]
          Length = 412

 Score =  139 bits (349), Expect = 1e-32
 Identities = 102/316 (32%), Positives = 152/316 (48%), Gaps = 22/316 (6%)

Query: 308 EEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYE 367
           E++ED+D L   +      S   S +            ++  +  +    G + FSL Y+
Sbjct: 78  EDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYESDDCTALGTLDFSLLYD 137

Query: 368 QQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDET 427
           Q+  +L   + +   L   D     ++PYVK +LLP  S+  K +T   R+T+NP ++ET
Sbjct: 138 QENNALHCTITKAKGLKPMDH-NGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNET 196

Query: 428 LRYE-IPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLD--KKLDHCLPLHGKI 484
           L Y  I +  + ++TL+ SV    +F  N F+GE  + +   K +  K  + CL     +
Sbjct: 197 LTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFNICLEKQLPV 256

Query: 485 SAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAG 544
                  L   +G +++SLKY               K G    L V I    +L A  A 
Sbjct: 257 DKTEDKSL-EERGRILISLKY------------SSQKQG----LLVGIVRCAHLAAMDAN 299

Query: 545 GTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDR 604
           G SD +VK YL P  +K SK KT V KKTLNP +N  F Y  ++  DL    LE+TVWD 
Sbjct: 300 GYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYE-IKHGDLAKKSLEVTVWDY 358

Query: 605 EPLASNDFLGGVRLGV 620
           +   SNDF+GGV LG+
Sbjct: 359 DIGKSNDFIGGVVLGI 374


>gi|209447073 synaptotagmin I [Homo sapiens]
          Length = 422

 Score =  135 bits (339), Expect = 2e-31
 Identities = 89/293 (30%), Positives = 145/293 (49%), Gaps = 38/293 (12%)

Query: 358 GRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKR 417
           G++ +SL Y+ Q   L+V + +  +L   D     S+PYVK +LLPDK +  K +T + R
Sbjct: 144 GKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGT-SDPYVKVFLLPDKKK--KFETKVHR 200

Query: 418 DTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHC 477
            T+NP+++E   +++P S L  +TL  +V+   RF ++  +GE ++ M++       +  
Sbjct: 201 KTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEW 260

Query: 478 LPLHGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKN 537
             L      E         G++  SL+Y+P +                G+L V I EAKN
Sbjct: 261 RDLQSAEKEEQ-----EKLGDICFSLRYVPTA----------------GKLTVVILEAKN 299

Query: 538 LTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCL 597
           L     GG SD +VK +L+    +  K+KT + K TLNP+YN +F +  V  E +Q + +
Sbjct: 300 LKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFE-VPFEQIQKVQV 358

Query: 598 ELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYP 650
            +TV D + +  ND +G V +G              +STG E+  W  M   P
Sbjct: 359 VVTVLDYDKIGKNDAIGKVFVG-------------YNSTGAELRHWSDMLANP 398


>gi|5032139 synaptotagmin I [Homo sapiens]
          Length = 422

 Score =  135 bits (339), Expect = 2e-31
 Identities = 89/293 (30%), Positives = 145/293 (49%), Gaps = 38/293 (12%)

Query: 358 GRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKR 417
           G++ +SL Y+ Q   L+V + +  +L   D     S+PYVK +LLPDK +  K +T + R
Sbjct: 144 GKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGT-SDPYVKVFLLPDKKK--KFETKVHR 200

Query: 418 DTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHC 477
            T+NP+++E   +++P S L  +TL  +V+   RF ++  +GE ++ M++       +  
Sbjct: 201 KTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEW 260

Query: 478 LPLHGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKN 537
             L      E         G++  SL+Y+P +                G+L V I EAKN
Sbjct: 261 RDLQSAEKEEQ-----EKLGDICFSLRYVPTA----------------GKLTVVILEAKN 299

Query: 538 LTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCL 597
           L     GG SD +VK +L+    +  K+KT + K TLNP+YN +F +  V  E +Q + +
Sbjct: 300 LKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFE-VPFEQIQKVQV 358

Query: 598 ELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYP 650
            +TV D + +  ND +G V +G              +STG E+  W  M   P
Sbjct: 359 VVTVLDYDKIGKNDAIGKVFVG-------------YNSTGAELRHWSDMLANP 398


>gi|209447070 synaptotagmin I [Homo sapiens]
          Length = 422

 Score =  135 bits (339), Expect = 2e-31
 Identities = 89/293 (30%), Positives = 145/293 (49%), Gaps = 38/293 (12%)

Query: 358 GRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKR 417
           G++ +SL Y+ Q   L+V + +  +L   D     S+PYVK +LLPDK +  K +T + R
Sbjct: 144 GKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGT-SDPYVKVFLLPDKKK--KFETKVHR 200

Query: 418 DTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHC 477
            T+NP+++E   +++P S L  +TL  +V+   RF ++  +GE ++ M++       +  
Sbjct: 201 KTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEW 260

Query: 478 LPLHGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKN 537
             L      E         G++  SL+Y+P +                G+L V I EAKN
Sbjct: 261 RDLQSAEKEEQ-----EKLGDICFSLRYVPTA----------------GKLTVVILEAKN 299

Query: 538 LTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCL 597
           L     GG SD +VK +L+    +  K+KT + K TLNP+YN +F +  V  E +Q + +
Sbjct: 300 LKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFE-VPFEQIQKVQV 358

Query: 598 ELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYP 650
            +TV D + +  ND +G V +G              +STG E+  W  M   P
Sbjct: 359 VVTVLDYDKIGKNDAIGKVFVG-------------YNSTGAELRHWSDMLANP 398


>gi|38570146 synaptotagmin VII [Homo sapiens]
          Length = 403

 Score =  131 bits (330), Expect = 2e-30
 Identities = 96/300 (32%), Positives = 149/300 (49%), Gaps = 44/300 (14%)

Query: 358 GRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKR 417
           GRI FS+ Y  Q  +L V + +  +L  A +    S+P+VK YLLPDK    K +T +KR
Sbjct: 137 GRIQFSVGYNFQESTLTVKIMKAQELP-AKDFSGTSDPFVKIYLLPDKKH--KLETKVKR 193

Query: 418 DTINPLYDETLRYE-IPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLD----- 471
             +NP ++ET  +E  P   + QR L   V  + RF RN  +GE  I ++   L      
Sbjct: 194 KNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTF 253

Query: 472 -KKLDHCLPLHGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQV 530
            K L  C    G             +GEL++SL Y P++ + +                V
Sbjct: 254 WKDLKPCSDGSGS------------RGELLLSLCYNPSANSII----------------V 285

Query: 531 WIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLE 590
            I +A+NL A   GGTSD +VK +L+    +  K+KT  MK+ LNP +N +F ++ +  E
Sbjct: 286 NIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFNESFAFD-IPTE 344

Query: 591 DLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTG---EEVSLWQKMR 647
            L+   + +TV D++ L+ ND +G + L   +G   GEV  W D      + V+ W +++
Sbjct: 345 KLRETTIIITVMDKDKLSRNDVIGKIYLSWKSG--PGEVKHWKDMIARPRQPVAQWHQLK 402


>gi|238550198 synaptotagmin III [Homo sapiens]
          Length = 590

 Score =  130 bits (326), Expect = 5e-30
 Identities = 94/284 (33%), Positives = 142/284 (50%), Gaps = 48/284 (16%)

Query: 348 AGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSR 407
           +G+ G     GRI+F+L+Y   +  LVV + +   L  A ++   S+PYVK YLLPD+ +
Sbjct: 291 SGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLP-AKDSNGFSDPYVKIYLLPDRKK 349

Query: 408 QGKRKTSIKRDTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDS 467
             K +T + R T+NP+++ET ++ +P + LAQR L FSV+   RF R+  +G+       
Sbjct: 350 --KFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQV------ 401

Query: 468 WKLDKKLDHCLPLHGKISAESPTGLP------------SHKGELVVSLKYIPASKTPVGG 515
                 LD+ L L     AE P   P            +  GEL  SL Y+P +      
Sbjct: 402 -----VLDNLLEL-----AEQPPDRPLWRDIVEGGSEKADLGELNFSLCYLPTA------ 445

Query: 516 DRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLN 575
                     G L V I +A NL A    G SD +VK  L+    +  KRKT + K TLN
Sbjct: 446 ----------GRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLN 495

Query: 576 PHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLG 619
           P YN   V++ V  E ++++ L + V D + +  N+ +G  R+G
Sbjct: 496 PTYNEALVFD-VAPESVENVGLSIAVVDYDCIGHNEVIGVCRVG 538



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 35/110 (31%), Positives = 54/110 (49%), Gaps = 1/110 (0%)

Query: 358 GRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKR 417
           G + FSL Y      L V + +   L   D     S+PYVK  L+ +  R  KRKTSIK+
Sbjct: 433 GELNFSLCYLPTAGRLTVTIIKASNLKAMD-LTGFSDPYVKASLISEGRRLKKRKTSIKK 491

Query: 418 DTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDS 467
           +T+NP Y+E L +++    +    L  +V  +   G N  +G   +  D+
Sbjct: 492 NTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDA 541


>gi|238550196 synaptotagmin III [Homo sapiens]
          Length = 590

 Score =  130 bits (326), Expect = 5e-30
 Identities = 94/284 (33%), Positives = 142/284 (50%), Gaps = 48/284 (16%)

Query: 348 AGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSR 407
           +G+ G     GRI+F+L+Y   +  LVV + +   L  A ++   S+PYVK YLLPD+ +
Sbjct: 291 SGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLP-AKDSNGFSDPYVKIYLLPDRKK 349

Query: 408 QGKRKTSIKRDTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDS 467
             K +T + R T+NP+++ET ++ +P + LAQR L FSV+   RF R+  +G+       
Sbjct: 350 --KFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQV------ 401

Query: 468 WKLDKKLDHCLPLHGKISAESPTGLP------------SHKGELVVSLKYIPASKTPVGG 515
                 LD+ L L     AE P   P            +  GEL  SL Y+P +      
Sbjct: 402 -----VLDNLLEL-----AEQPPDRPLWRDIVEGGSEKADLGELNFSLCYLPTA------ 445

Query: 516 DRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLN 575
                     G L V I +A NL A    G SD +VK  L+    +  KRKT + K TLN
Sbjct: 446 ----------GRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLN 495

Query: 576 PHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLG 619
           P YN   V++ V  E ++++ L + V D + +  N+ +G  R+G
Sbjct: 496 PTYNEALVFD-VAPESVENVGLSIAVVDYDCIGHNEVIGVCRVG 538



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 35/110 (31%), Positives = 54/110 (49%), Gaps = 1/110 (0%)

Query: 358 GRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKR 417
           G + FSL Y      L V + +   L   D     S+PYVK  L+ +  R  KRKTSIK+
Sbjct: 433 GELNFSLCYLPTAGRLTVTIIKASNLKAMD-LTGFSDPYVKASLISEGRRLKKRKTSIKK 491

Query: 418 DTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDS 467
           +T+NP Y+E L +++    +    L  +V  +   G N  +G   +  D+
Sbjct: 492 NTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDA 541


>gi|14150054 synaptotagmin III [Homo sapiens]
          Length = 590

 Score =  130 bits (326), Expect = 5e-30
 Identities = 94/284 (33%), Positives = 142/284 (50%), Gaps = 48/284 (16%)

Query: 348 AGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSR 407
           +G+ G     GRI+F+L+Y   +  LVV + +   L  A ++   S+PYVK YLLPD+ +
Sbjct: 291 SGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLP-AKDSNGFSDPYVKIYLLPDRKK 349

Query: 408 QGKRKTSIKRDTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDS 467
             K +T + R T+NP+++ET ++ +P + LAQR L FSV+   RF R+  +G+       
Sbjct: 350 --KFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQV------ 401

Query: 468 WKLDKKLDHCLPLHGKISAESPTGLP------------SHKGELVVSLKYIPASKTPVGG 515
                 LD+ L L     AE P   P            +  GEL  SL Y+P +      
Sbjct: 402 -----VLDNLLEL-----AEQPPDRPLWRDIVEGGSEKADLGELNFSLCYLPTA------ 445

Query: 516 DRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLN 575
                     G L V I +A NL A    G SD +VK  L+    +  KRKT + K TLN
Sbjct: 446 ----------GRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLN 495

Query: 576 PHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLG 619
           P YN   V++ V  E ++++ L + V D + +  N+ +G  R+G
Sbjct: 496 PTYNEALVFD-VAPESVENVGLSIAVVDYDCIGHNEVIGVCRVG 538



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 35/110 (31%), Positives = 54/110 (49%), Gaps = 1/110 (0%)

Query: 358 GRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKR 417
           G + FSL Y      L V + +   L   D     S+PYVK  L+ +  R  KRKTSIK+
Sbjct: 433 GELNFSLCYLPTAGRLTVTIIKASNLKAMD-LTGFSDPYVKASLISEGRRLKKRKTSIKK 491

Query: 418 DTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDS 467
           +T+NP Y+E L +++    +    L  +V  +   G N  +G   +  D+
Sbjct: 492 NTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDA 541


>gi|39752671 synaptotagmin X [Homo sapiens]
          Length = 523

 Score =  125 bits (314), Expect = 1e-28
 Identities = 89/331 (26%), Positives = 162/331 (48%), Gaps = 32/331 (9%)

Query: 329 MQSGSSMSTIGSMM-------SIYSEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECH 381
           +Q G + ++IG +        S+ SE     ++ + G++ F+L+Y+ + + LVV + +  
Sbjct: 197 LQRGETTTSIGRIKPELYKQKSVDSEGNQNEDVKICGKLNFTLQYDYENELLVVKIIKAL 256

Query: 382 QLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYEIPESLLAQRT 441
            L  A +    S+PYVK YLLPD+ +  K +T + R T+NPL+DET ++ +    L+ R 
Sbjct: 257 DLP-AKDFTGTSDPYVKMYLLPDRKK--KFQTRVHRKTLNPLFDETFQFPVAYDQLSNRK 313

Query: 442 LQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPTGLPSHKGELVV 501
           L FSV+   RF R+  +G  E+ +D+      L     +   I   +   +    GE++ 
Sbjct: 314 LHFSVYDFDRFSRHDMIG--EVILDNLFEVSDLSREATVWKDIHCATTESI--DLGEIMF 369

Query: 502 SLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNK 561
           SL Y+P +                G + + + + +NL A    G+SD +VK  L+    +
Sbjct: 370 SLCYLPTA----------------GRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRR 413

Query: 562 ASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGV- 620
             KRKT   K TLNP YN   +++ +  E++  + L + V D + +  N+ +G  R G+ 
Sbjct: 414 LKKRKTTTKKNTLNPVYNEAIIFD-IPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLD 472

Query: 621 GTGISNGEVVDWMDSTGEEVSLWQKMRQYPG 651
             G+      + +    + ++ W  + + PG
Sbjct: 473 AEGLGRDHWNEMLAYHRKPITHWHPLLELPG 503


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.131    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,983,415
Number of Sequences: 37866
Number of extensions: 1233245
Number of successful extensions: 4990
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 95
Number of HSP's successfully gapped in prelim test: 114
Number of HSP's that attempted gapping in prelim test: 4296
Number of HSP's gapped (non-prelim): 515
length of query: 671
length of database: 18,247,518
effective HSP length: 109
effective length of query: 562
effective length of database: 14,120,124
effective search space: 7935509688
effective search space used: 7935509688
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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