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Search of human proteins with 189409124
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|189409124 armadillo repeat containing 3 [Homo sapiens]
(872 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|189409124 armadillo repeat containing 3 [Homo sapiens] 1706 0.0
gi|31657114 armadillo repeat containing 4 [Homo sapiens] 88 4e-17
gi|4504811 junction plakoglobin [Homo sapiens] 76 2e-13
gi|12056468 junction plakoglobin [Homo sapiens] 76 2e-13
gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens] 70 7e-12
gi|148227672 catenin (cadherin-associated protein), beta 1, 88kD... 67 7e-11
gi|148233338 catenin (cadherin-associated protein), beta 1, 88kD... 67 7e-11
gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa ... 67 7e-11
gi|28875784 armadillo repeat containing 5 isoform b [Homo sapiens] 59 1e-08
gi|157426856 armadillo repeat containing 5 isoform a [Homo sapiens] 59 1e-08
gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2 [... 59 2e-08
gi|39812229 karyopherin alpha 5 [Homo sapiens] 57 7e-08
gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5 [... 55 4e-07
gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4 [... 55 4e-07
gi|155030202 RAP1, GTP-GDP dissociation stimulator 1 isoform 6 [... 54 5e-07
gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3 [... 54 5e-07
gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1 [... 54 5e-07
gi|4502247 armadillo repeat protein [Homo sapiens] 54 5e-07
gi|207029299 NIMA-related kinase 10 isoform 3 [Homo sapiens] 54 8e-07
gi|224589129 karyopherin 7 [Homo sapiens] 53 1e-06
gi|222144293 karyopherin alpha 1 [Homo sapiens] 51 4e-06
gi|11034811 catenin (cadherin-associated protein), delta 2 (neur... 51 5e-06
gi|34485722 karyopherin alpha 3 [Homo sapiens] 50 1e-05
gi|7657530 rhabdoid tumor deletion region protein 1 [Homo sapiens] 48 3e-05
gi|4504901 karyopherin alpha 4 [Homo sapiens] 48 3e-05
gi|4504897 karyopherin alpha 2 [Homo sapiens] 47 6e-05
gi|53829376 plakophilin 4 isoform b [Homo sapiens] 46 1e-04
gi|53829374 plakophilin 4 isoform a [Homo sapiens] 46 1e-04
gi|6005830 plakophilin 3 [Homo sapiens] 45 4e-04
gi|7662162 ALEX2 protein [Homo sapiens] 45 4e-04
>gi|189409124 armadillo repeat containing 3 [Homo sapiens]
Length = 872
Score = 1706 bits (4418), Expect = 0.0
Identities = 872/872 (100%), Positives = 872/872 (100%)
Query: 1 MGKKIKKEVEPPPKDVFDPLMIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENK 60
MGKKIKKEVEPPPKDVFDPLMIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENK
Sbjct: 1 MGKKIKKEVEPPPKDVFDPLMIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENK 60
Query: 61 TTLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPE 120
TTLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPE
Sbjct: 61 TTLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPE 120
Query: 121 EEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQD 180
EEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQD
Sbjct: 121 EEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQD 180
Query: 181 FQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKI 240
FQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKI
Sbjct: 181 FQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKI 240
Query: 241 LETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAIT 300
LETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAIT
Sbjct: 241 LETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAIT 300
Query: 301 KAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIPQ 360
KAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIPQ
Sbjct: 301 KAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIPQ 360
Query: 361 LIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAAT 420
LIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAAT
Sbjct: 361 LIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAAT 420
Query: 421 VLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACDVEARTELRNSG 480
VLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACDVEARTELRNSG
Sbjct: 421 VLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACDVEARTELRNSG 480
Query: 481 GLEPLVELLRSKNDEVRKHASWAVMVCAGDELTANELCRLGALDILEEVNVSGTRKNKFS 540
GLEPLVELLRSKNDEVRKHASWAVMVCAGDELTANELCRLGALDILEEVNVSGTRKNKFS
Sbjct: 481 GLEPLVELLRSKNDEVRKHASWAVMVCAGDELTANELCRLGALDILEEVNVSGTRKNKFS 540
Query: 541 EAAYNKLLNNNLSLKYSQTGYLSSSNIINDGFYDYGRINPGTKLLPLKELCLQEPSDLRA 600
EAAYNKLLNNNLSLKYSQTGYLSSSNIINDGFYDYGRINPGTKLLPLKELCLQEPSDLRA
Sbjct: 541 EAAYNKLLNNNLSLKYSQTGYLSSSNIINDGFYDYGRINPGTKLLPLKELCLQEPSDLRA 600
Query: 601 VLLINSKSYVSPPSSMEDKSDVGYGRSISSSSSLRRSSKEKNKKNSYHFSAGFGSPIEDK 660
VLLINSKSYVSPPSSMEDKSDVGYGRSISSSSSLRRSSKEKNKKNSYHFSAGFGSPIEDK
Sbjct: 601 VLLINSKSYVSPPSSMEDKSDVGYGRSISSSSSLRRSSKEKNKKNSYHFSAGFGSPIEDK 660
Query: 661 SEPASGRNTVLSKSATKEKGWRKSKGKKEEEKVKEEEEVMVVPKFVGEGSSDKEWCPPSD 720
SEPASGRNTVLSKSATKEKGWRKSKGKKEEEKVKEEEEVMVVPKFVGEGSSDKEWCPPSD
Sbjct: 661 SEPASGRNTVLSKSATKEKGWRKSKGKKEEEKVKEEEEVMVVPKFVGEGSSDKEWCPPSD 720
Query: 721 PDFSMYVYEVTKSILPITNIKEQIEDLAKYVAEKMGGKIPKEKLPDFSWELHISELKFQL 780
PDFSMYVYEVTKSILPITNIKEQIEDLAKYVAEKMGGKIPKEKLPDFSWELHISELKFQL
Sbjct: 721 PDFSMYVYEVTKSILPITNIKEQIEDLAKYVAEKMGGKIPKEKLPDFSWELHISELKFQL 780
Query: 781 KSNVIPIGHVKKGIFYHRALLFKALADRIGIGCSLVRGEYGRAWNEVMLQNDSRKGVIGG 840
KSNVIPIGHVKKGIFYHRALLFKALADRIGIGCSLVRGEYGRAWNEVMLQNDSRKGVIGG
Sbjct: 781 KSNVIPIGHVKKGIFYHRALLFKALADRIGIGCSLVRGEYGRAWNEVMLQNDSRKGVIGG 840
Query: 841 LPAPEMYVIDLMFHPGGLMKLRSREADLYRFI 872
LPAPEMYVIDLMFHPGGLMKLRSREADLYRFI
Sbjct: 841 LPAPEMYVIDLMFHPGGLMKLRSREADLYRFI 872
>gi|31657114 armadillo repeat containing 4 [Homo sapiens]
Length = 1044
Score = 87.8 bits (216), Expect = 4e-17
Identities = 97/506 (19%), Positives = 205/506 (40%), Gaps = 19/506 (3%)
Query: 60 KTTLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNNDVKKLLRELDVMNSVIA---- 115
+ +++LG + + +L K ++ A +A ++++R+ + ++A
Sbjct: 528 RQNIVDLGGLPIMVNILDSPHKSLKCLAAETIANVAKFKRARRVVRQHGGITKLVALLDC 587
Query: 116 ----------QLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPD 165
L +V + +L L + S +T+K I + GG+ L RLL + +
Sbjct: 588 AHDSTKPAQSSLYEARDVEVARCGALALWSCSKSHTNKEAIRKAGGIPLLARLLKTSHEN 647
Query: 166 VKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESR 225
+ + + + RA ++ I ++ L SE +Q + A DKE+R
Sbjct: 648 MLIPVVGTLQECASEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCAEDKETR 707
Query: 226 TMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAEN 285
++R + GL L +L + + I C + + + ++ ++ L+ +
Sbjct: 708 DLVRLHGGLKPLASLLNNTDNKERLAAVTGAIWKCSISKENVTKFREYKAIETLVGLLTD 767
Query: 286 STIPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCE 345
++ N A+ + + ENR + + + LV LL N + ++A+ A
Sbjct: 768 QP-EEVLVNVVGALGECCQERENRVIVRKCGGIQPLVNLLVGINQALLVNVTKAVGACAV 826
Query: 346 NSGSKDFFNN-QGIPQLIQLLKSDNEEVREAAALALAN-LTTCNPANANAAAEADGIDPL 403
S + G+ L LLK+ + +V+ +AA AL + A + G++ +
Sbjct: 827 EPESMMIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVGGLELI 886
Query: 404 INLLSSKRDGAIANAATVLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAV 463
+NLL S +A+ +TN+A + I +H ++ + + N ++ A A+
Sbjct: 887 VNLLKSDNKEVLASVCAAITNIAKDQENLAVITDHGVVPLLSKLANTNNNKLRHHLAEAI 946
Query: 464 TATACDVEARTELRNSGGLEPLVELLRSKNDEVRKHASWAVMVCAGDELTANELCRLGAL 523
+ R + PLV L+S + V + + A+ + D + GA+
Sbjct: 947 SRCCMWGRNRVAFGEHKAVAPLVRYLKSNDTNVHRATAQALYQLSEDADNCITMHENGAV 1006
Query: 524 DILEEVNVSGTRKNKFSEAAYNKLLN 549
+L +++ G+ EAA + N
Sbjct: 1007 KLL--LDMVGSPDQDLQEAAAGCISN 1030
Score = 80.1 bits (196), Expect = 8e-15
Identities = 103/445 (23%), Positives = 182/445 (40%), Gaps = 24/445 (5%)
Query: 113 VIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSME 172
V+ L +EV + L +S + I + GGL ++ +L SP +K + E
Sbjct: 498 VLINLLETDEVKCKIGSLKILKEISHNPQIRQNIVDLGGLPIMVNILDSPHKSLKCLAAE 557
Query: 173 CIYNLVQDFQCRAKLQELNAIPPILDLL----------KSEYPVIQLLALKTLGVIA--- 219
I N+ + + R +++ I ++ LL +S + + + G +A
Sbjct: 558 TIANVAKFKRARRVVRQHGGITKLVALLDCAHDSTKPAQSSLYEARDVEVARCGALALWS 617
Query: 220 --NDKESRTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLK 277
++ +R G+ L ++L+T N L I + + C + + I+ ++
Sbjct: 618 CSKSHTNKEAIRKAGGIPLLARLLKTSHENML-IPVVGTLQECASEENYRAAIKAERIIE 676
Query: 278 KLLSFAENSTIPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAAS 337
L+ NS +Q++ A AI + A D E R L K L +LL + ++ ++AA
Sbjct: 677 NLVKNL-NSENEQLQEHCAMAIYQCAEDKETRDLVRLHGGLKPLASLLNNTDNKERLAAV 735
Query: 338 QAISAMCENSGSK--DFFNNQGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAA 395
C S F + I L+ LL EEV AL N
Sbjct: 736 TGAIWKCSISKENVTKFREYKAIETLVGLLTDQPEEVLVNVVGALGECCQ-ERENRVIVR 794
Query: 396 EADGIDPLINLLSSKRDGAIANAATVLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVV 455
+ GI PL+NLL + N + A++ + I D + + S L++ + V
Sbjct: 795 KCGGIQPLVNLLVGINQALLVNVTKAVGACAVEPESMMIIDRLDGVRLLWSLLKNPHPDV 854
Query: 456 QSKAALAVTATACDVEARTELRNS--GGLEPLVELLRSKNDEVRKHASWAVMVCAGDELT 513
++ AA A+ + + E+ S GGLE +V LL+S N EV A+ A D+
Sbjct: 855 KASAAWALCPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKEVLASVCAAITNIAKDQEN 914
Query: 514 ANELCRLGALDILEEVNVSGTRKNK 538
+ G + +L + ++ T NK
Sbjct: 915 LAVITDHGVVPLLSK--LANTNNNK 937
Score = 73.9 bits (180), Expect = 6e-13
Identities = 81/318 (25%), Positives = 137/318 (43%), Gaps = 30/318 (9%)
Query: 193 IPPILDLLKSEYPVIQLLALKTLGVIANDKES-RTMLRDNQGLDHLIKILETKELNDLHI 251
I ++ LK ++AL ++ + +E+ + +RD GL+ LI +LET E+ I
Sbjct: 454 IQKLVKYLKGGNQTATVIALCSMRDFSLAQETCQLAIRDVGGLEVLINLLETDEVK-CKI 512
Query: 252 EALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPENRKL 311
+L ++ + I GGL +++ + S ++ AA+ I A R++
Sbjct: 513 GSLKILKEISHNPQIRQNIVDLGGLPIMVNILD-SPHKSLKCLAAETIANVAKFKRARRV 571
Query: 312 FHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIPQLIQLLKSDNEE 371
+ LVALL +D TK A S L ++ + E
Sbjct: 572 VRQHGGITKLVALLDCAHDSTKPAQSS-------------------------LYEARDVE 606
Query: 372 VREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNMAMQEPL 431
V ALAL + + + N A +A GI L LL + + + L A +E
Sbjct: 607 VARCGALALWSCSKSH-TNKEAIRKAGGIPLLARLLKTSHENMLIPVVGTLQECASEENY 665
Query: 432 RLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACDVEARTELRNSGGLEPLVELLRS 491
R I+ I+ ++ L S N +Q A+A+ A D E R +R GGL+PL LL +
Sbjct: 666 RAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCAEDKETRDLVRLHGGLKPLASLLNN 725
Query: 492 KNDEVRKHA-SWAVMVCA 508
+++ R A + A+ C+
Sbjct: 726 TDNKERLAAVTGAIWKCS 743
Score = 70.5 bits (171), Expect = 7e-12
Identities = 80/354 (22%), Positives = 151/354 (42%), Gaps = 46/354 (12%)
Query: 32 LMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATMIF 91
L+ N+ +E LA AI+K ++ +EN T E A+E L LLT +
Sbjct: 722 LLNNTDNKERLAAVTGAIWKCSIS-KENVTKFREYKAIETLVGLLTDQ------------ 768
Query: 92 GILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGG 151
EEV+++ + L E ++V + + GG
Sbjct: 769 ----------------------------PEEVLVNVVGA--LGECCQERENRVIVRKCGG 798
Query: 152 LEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLA 211
++PL+ LL + + N + + + + + L+ + + LLK+ +P ++ A
Sbjct: 799 IQPLVNLLVGINQALLVNVTKAVGACAVEPESMMIIDRLDGVRLLWSLLKNPHPDVKASA 858
Query: 212 LKTL-GVIANDKESRTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQI 270
L I N K++ M+R G LI L + ++ A I N +D + + I
Sbjct: 859 AWALCPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKEVLASVCAAITNIAKDQENLAVI 918
Query: 271 QQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSEND 330
G+ LLS N+ ++ + A+AI++ NR F E + LV L S +
Sbjct: 919 TD-HGVVPLLSKLANTNNNKLRHHLAEAISRCCMWGRNRVAFGEHKAVAPLVRYLKSNDT 977
Query: 331 GTKIAASQAISAMCENSGS-KDFFNNQGIPQLIQLLKSDNEEVREAAALALANL 383
A +QA+ + E++ + N + L+ ++ S +++++EAAA ++N+
Sbjct: 978 NVHRATAQALYQLSEDADNCITMHENGAVKLLLDMVGSPDQDLQEAAAGCISNI 1031
Score = 65.1 bits (157), Expect = 3e-10
Identities = 60/279 (21%), Positives = 122/279 (43%), Gaps = 4/279 (1%)
Query: 23 ESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKI 82
E K T+V +L EE+L A+ + + EN+ + + G ++PL LL ++
Sbjct: 754 EYKAIETLVGLLTDQPEEVLVNVVGALGE-CCQERENRVIVRKCGGIQPLVNLLVGINQA 812
Query: 83 VRRNATMIFGILASNNDVKKLLRELDVMNSVIAQLA-PEEEVVIHEFASLCLANMSAEYT 141
+ N T G A + ++ LD + + + L P +V +LC +A+
Sbjct: 813 LLVNVTKAVGACAVEPESMMIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDA 872
Query: 142 SKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLK 201
++ GGLE ++ LL S + +V + I N+ +D + A + + +P + L
Sbjct: 873 GEMVRSFVGGLELIVNLLKSDNKEVLASVCAAITNIAKDQENLAVITDHGVVPLLSKLAN 932
Query: 202 SEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCL 261
+ ++ + + +R +++ + L++ L++ + N +H +
Sbjct: 933 TNNNKLRHHLAEAISRCCMWGRNRVAFGEHKAVAPLVRYLKSNDTN-VHRATAQALYQLS 991
Query: 262 EDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAIT 300
ED D + + + G +K LL S D+Q+ AA I+
Sbjct: 992 EDADNCITMHENGAVKLLLDMV-GSPDQDLQEAAAGCIS 1029
Score = 48.9 bits (115), Expect = 2e-05
Identities = 34/148 (22%), Positives = 68/148 (45%), Gaps = 2/148 (1%)
Query: 30 VVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATM 89
+V +L S +E+LA C AI A K +EN + + G V L+KL + +R +
Sbjct: 886 IVNLLKSDNKEVLASVCAAITNIA-KDQENLAVITDHGVVPLLSKLANTNNNKLRHHLAE 944
Query: 90 IFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEH 149
+ E + ++ L + +H + L +S + + + + E+
Sbjct: 945 AISRCCMWGRNRVAFGEHKAVAPLVRYLK-SNDTNVHRATAQALYQLSEDADNCITMHEN 1003
Query: 150 GGLEPLIRLLSSPDPDVKKNSMECIYNL 177
G ++ L+ ++ SPD D+++ + CI N+
Sbjct: 1004 GAVKLLLDMVGSPDQDLQEAAAGCISNI 1031
>gi|4504811 junction plakoglobin [Homo sapiens]
Length = 745
Score = 75.9 bits (185), Expect = 2e-13
Identities = 105/480 (21%), Positives = 205/480 (42%), Gaps = 48/480 (10%)
Query: 68 AVEPLTKLLTHEDKIVRRNATMIFGILASNNDVKK-LLRELDVMNSVIAQLAPEEEVVIH 126
A+ LTKLL ED +V A MI L+ ++ L+ ++ +V+ + ++
Sbjct: 143 ALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTA 202
Query: 127 EFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAK 186
+ L N+S + IF+ GG+ L+R+LSSP V ++ ++NL+ +Q AK
Sbjct: 203 RCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLL-YQEGAK 261
Query: 187 L--QELNAIPPILDLLKSEYPVIQLLALKTLGVIA-NDKESRTMLRDNQGLDHLIKILET 243
+ + + + ++ LL P + L ++A ++ES+ ++ N G L++I+
Sbjct: 262 MAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRN 321
Query: 244 KELNDL---HIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKN---AAK 297
L L V++ C + +V + GG++ L S P + +N +
Sbjct: 322 YSYEKLLWTTSRVLKVLSVCPSNKPAIV---EAGGMQALGKHL-TSNSPRLVQNCLWTLR 377
Query: 298 AITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAM-CENSGSKDFF-NN 355
++ A E + V K LV L ++ A+ +S + C NS +K N
Sbjct: 378 NLSDVATKQEGL-----ESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQN 432
Query: 356 QGIPQLIQ--LLKSDNEEVREAAALALANLTTCNP---ANANAAAEADGIDPLINLLSSK 410
G+ LI L D +++ E A AL +LT+ +P N+ GI ++ LL+
Sbjct: 433 SGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQP 492
Query: 411 RDGAIANAAT-VLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACD 469
+ A ++ N+A+ +Q ++ ++ L A+ Q A
Sbjct: 493 NQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA--------- 543
Query: 470 VEARTELRNSGGLEPLVELLRSKNDEVRKHASWAVMVCAGDELTANELCRLGALDILEEV 529
+G +P + +R +E+ + + A+ + A D + E+ RL + + ++
Sbjct: 544 ---------AGTQQPYTDGVRM--EEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQL 592
Score = 42.0 bits (97), Expect = 0.002
Identities = 81/373 (21%), Positives = 150/373 (40%), Gaps = 42/373 (11%)
Query: 28 ATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNA 87
A V +M N E++L + K NK ++E G ++ L K LT + +N
Sbjct: 314 ALVQIMRNYSYEKLLWTTSRVL-KVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNC 372
Query: 88 TMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYT-SKVQI 146
L + +DV L+ + ++ ++V + A+ L+N++ + +K +
Sbjct: 373 LWT---LRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLV 429
Query: 147 FEHGGLEPLIR-LLSSPDPDVKKNSMECIYNLVQDFQCRAKLQE----LN-AIPPILDLL 200
++ G+E LI +L + D D C + A++ + LN IP I+ LL
Sbjct: 430 TQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLL 489
Query: 201 K--SEYPVIQLLALKTLGVIAN---DKESRTMLRDNQGLDHLIKILETKELNDLHIEALA 255
+++P+++ T+G+I N + L++ + L+++L K D A
Sbjct: 490 NQPNQWPLVKA----TIGLIRNLALCPANHAPLQEAAVIPRLVQLL-VKAHQDAQRHVAA 544
Query: 256 VIANCLEDMDTMVQIQQ--TGGLKKLLSFAEN------------------STIPDIQKNA 295
D M +I + TG L L N S++ +IQ+ A
Sbjct: 545 GTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVA 604
Query: 296 AKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNN 355
A + + A D E + L+ LL S N+GT A+ + + E+ + D+
Sbjct: 605 AGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDK-NPDYRKR 663
Query: 356 QGIPQLIQLLKSD 368
+ L K D
Sbjct: 664 VSVELTNSLFKHD 676
>gi|12056468 junction plakoglobin [Homo sapiens]
Length = 745
Score = 75.9 bits (185), Expect = 2e-13
Identities = 105/480 (21%), Positives = 205/480 (42%), Gaps = 48/480 (10%)
Query: 68 AVEPLTKLLTHEDKIVRRNATMIFGILASNNDVKK-LLRELDVMNSVIAQLAPEEEVVIH 126
A+ LTKLL ED +V A MI L+ ++ L+ ++ +V+ + ++
Sbjct: 143 ALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTA 202
Query: 127 EFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAK 186
+ L N+S + IF+ GG+ L+R+LSSP V ++ ++NL+ +Q AK
Sbjct: 203 RCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLL-YQEGAK 261
Query: 187 L--QELNAIPPILDLLKSEYPVIQLLALKTLGVIA-NDKESRTMLRDNQGLDHLIKILET 243
+ + + + ++ LL P + L ++A ++ES+ ++ N G L++I+
Sbjct: 262 MAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRN 321
Query: 244 KELNDL---HIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKN---AAK 297
L L V++ C + +V + GG++ L S P + +N +
Sbjct: 322 YSYEKLLWTTSRVLKVLSVCPSNKPAIV---EAGGMQALGKHL-TSNSPRLVQNCLWTLR 377
Query: 298 AITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAM-CENSGSKDFF-NN 355
++ A E + V K LV L ++ A+ +S + C NS +K N
Sbjct: 378 NLSDVATKQEGL-----ESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQN 432
Query: 356 QGIPQLIQ--LLKSDNEEVREAAALALANLTTCNP---ANANAAAEADGIDPLINLLSSK 410
G+ LI L D +++ E A AL +LT+ +P N+ GI ++ LL+
Sbjct: 433 SGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQP 492
Query: 411 RDGAIANAAT-VLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACD 469
+ A ++ N+A+ +Q ++ ++ L A+ Q A
Sbjct: 493 NQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA--------- 543
Query: 470 VEARTELRNSGGLEPLVELLRSKNDEVRKHASWAVMVCAGDELTANELCRLGALDILEEV 529
+G +P + +R +E+ + + A+ + A D + E+ RL + + ++
Sbjct: 544 ---------AGTQQPYTDGVRM--EEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQL 592
Score = 42.0 bits (97), Expect = 0.002
Identities = 81/373 (21%), Positives = 150/373 (40%), Gaps = 42/373 (11%)
Query: 28 ATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNA 87
A V +M N E++L + K NK ++E G ++ L K LT + +N
Sbjct: 314 ALVQIMRNYSYEKLLWTTSRVL-KVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNC 372
Query: 88 TMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYT-SKVQI 146
L + +DV L+ + ++ ++V + A+ L+N++ + +K +
Sbjct: 373 LWT---LRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLV 429
Query: 147 FEHGGLEPLIR-LLSSPDPDVKKNSMECIYNLVQDFQCRAKLQE----LN-AIPPILDLL 200
++ G+E LI +L + D D C + A++ + LN IP I+ LL
Sbjct: 430 TQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLL 489
Query: 201 K--SEYPVIQLLALKTLGVIAN---DKESRTMLRDNQGLDHLIKILETKELNDLHIEALA 255
+++P+++ T+G+I N + L++ + L+++L K D A
Sbjct: 490 NQPNQWPLVKA----TIGLIRNLALCPANHAPLQEAAVIPRLVQLL-VKAHQDAQRHVAA 544
Query: 256 VIANCLEDMDTMVQIQQ--TGGLKKLLSFAEN------------------STIPDIQKNA 295
D M +I + TG L L N S++ +IQ+ A
Sbjct: 545 GTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVA 604
Query: 296 AKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNN 355
A + + A D E + L+ LL S N+GT A+ + + E+ + D+
Sbjct: 605 AGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDK-NPDYRKR 663
Query: 356 QGIPQLIQLLKSD 368
+ L K D
Sbjct: 664 VSVELTNSLFKHD 676
>gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]
Length = 1363
Score = 70.5 bits (171), Expect = 7e-12
Identities = 97/468 (20%), Positives = 203/468 (43%), Gaps = 24/468 (5%)
Query: 60 KTTLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNNDVK-KLLRELDVMNSVIAQLA 118
K + EL + L ++L E R A M ++ ND + + + + ++I L
Sbjct: 622 KLNIPELPVWKTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLK 681
Query: 119 PEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLV 178
+ + + L L+N+S ++ + E GG+ LI LL +P+V +Y++
Sbjct: 682 SSKIKLQCKTVGL-LSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIA 740
Query: 179 QDFQCRAK--LQELNAIPPILDLLKSEYPVIQLLALKTLGVIA-NDKESRTMLRDNQGLD 235
QC K + + N IP +++LL + + + + V+ ++ ++ +R+++GL
Sbjct: 741 ---QCENKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLP 797
Query: 236 HLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNA 295
+LI+ L + + + A+ ++ + I G + L++ + I K A
Sbjct: 798 YLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGA 857
Query: 296 AKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENS--GSKDFF 353
+ A+++ +K F E+ + K L+ LL + K + A+ A+ + K
Sbjct: 858 MAVESLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMA 917
Query: 354 NNQGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLL--SSKR 411
G +I +L S + +++ A+ L+ + + N E +GI PL+ LL S+
Sbjct: 918 EQIGYSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRISTIA 977
Query: 412 DGAIANAATVLTNMAMQEPLRLN------IQNHDIMHAIISPLR---SANTVVQSKAALA 462
+G + + + ++ + N + + + +I LR S N V+ +LA
Sbjct: 978 EGTLLSVIRAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLLRNHPSPNIKVEVAFSLA 1037
Query: 463 VTATACDVEARTELRNSGGLE--PLVELLRSKNDEVRKHASWAVMVCA 508
DV + +L + G E ++ LL S ++ A +A+ + A
Sbjct: 1038 CIVLGNDV-LQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFA 1084
Score = 60.1 bits (144), Expect = 9e-09
Identities = 71/366 (19%), Positives = 162/366 (44%), Gaps = 16/366 (4%)
Query: 165 DVKKN-----SMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVI- 218
D+K N S+ + V + + + EL ++++L+ E +++A+ +L VI
Sbjct: 598 DIKGNNIIHLSVLTFHTEVLKYIIKLNIPELPVWKTLVEMLQCESYKRRMMAVMSLEVIC 657
Query: 219 -ANDKESRTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLK 277
AND+ R +L D + LI +L++ ++ L + + +++N + + + GG+
Sbjct: 658 LANDQYWRCIL-DAGTIPALINLLKSSKIK-LQCKTVGLLSNISTHKSAVHALVEAGGIP 715
Query: 278 KLLSFAENSTIPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAAS 337
L++ P++ A + A EN+ + + L+ LL + +
Sbjct: 716 SLINLLVCDE-PEVHSRCAVILYDIA-QCENKDVIAKYNGIPSLINLLNLNIENVLVNVM 773
Query: 338 QAISAMC--ENSGSKDFFNNQGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAA 395
I +C + + ++G+P LI+ L SD++ ++ ++ A+A + N +A A
Sbjct: 774 NCIRVLCIGNENNQRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIA 833
Query: 396 EADGIDPLINLLSSKRDGAIANAATVLTNMAMQEPL-RLNIQNHDIMHAIISPLRSANTV 454
I PL+ L K+ A + ++A L + + ++ L++
Sbjct: 834 MEGAIPPLVALFKGKQISVQMKGAMAVESLASHNALIQKAFLEKSLTKYLLKLLKAFQID 893
Query: 455 VQSKAALAVTATACD-VEARTELRNSGGLEPLVELLRSKNDEVRKHASWAVMVCAGD-EL 512
V+ + A+A+ A A ++ + + G ++ +L S + +++ AV+ + D +
Sbjct: 894 VKEQGAVALWALAGQTLKQQKYMAEQIGYSFIINMLLSPSAKMQYVGGEAVIALSKDSRM 953
Query: 513 TANELC 518
N++C
Sbjct: 954 HQNQIC 959
Score = 39.3 bits (90), Expect = 0.016
Identities = 63/297 (21%), Positives = 130/297 (43%), Gaps = 16/297 (5%)
Query: 23 ESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKI 82
E K ++ L+S + + A + AI + +E + + GA+ PL L +
Sbjct: 792 EHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQIS 851
Query: 83 VRRNATMIFGILASNND-VKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYT 141
V+ M LAS+N ++K E + + +L ++ + E ++ L ++ + T
Sbjct: 852 VQMKGAMAVESLASHNALIQKAFLEKS-LTKYLLKLLKAFQIDVKEQGAVALWALAGQ-T 909
Query: 142 SKVQIF--EHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQC-RAKLQELNAIPPILD 198
K Q + E G +I +L SP ++ E + L +D + + ++ E N I P++
Sbjct: 910 LKQQKYMAEQIGYSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQICEGNGIAPLVR 969
Query: 199 LLK-------SEYPVIQLLALKTLGVI-ANDKESRTMLRDNQGLDHLIKILETKELNDLH 250
LL+ + VI+ + +GV ++ S+ + D LI++L ++
Sbjct: 970 LLRISTIAEGTLLSVIRAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLLRNHPSPNIK 1029
Query: 251 IEALAVIANCLEDMDTMVQ-IQQTGGLKKL-LSFAENSTIPDIQKNAAKAITKAAYD 305
+E +A + D + + + + G + + + +ST DI A A+T A++
Sbjct: 1030 VEVAFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFN 1086
>gi|148227672 catenin (cadherin-associated protein), beta 1, 88kDa
[Homo sapiens]
Length = 781
Score = 67.0 bits (162), Expect = 7e-11
Identities = 88/445 (19%), Positives = 174/445 (39%), Gaps = 55/445 (12%)
Query: 68 AVEPLTKLLTHEDKIV-RRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIH 126
A+ LTKLL ED++V + A M+ + ++R ++++++ + +V
Sbjct: 152 AIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETA 211
Query: 127 EFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQ-CRA 185
+ L N+S + IF+ GG+ L+++L SP V ++ ++NL+ + +
Sbjct: 212 RCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKM 271
Query: 186 KLQELNAIPPILDLLKSEYPVIQLLALKTLGVIA-NDKESRTMLRDNQGLDHLIKILETK 244
++ + ++ LL + L ++A ++ES+ ++ + G L+ I+ T
Sbjct: 272 AVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTY 331
Query: 245 ELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAY 304
L + T + K+LS ++ ++ +A+
Sbjct: 332 TYEKL--------------------LWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLT 371
Query: 305 DPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIPQLIQL 364
DP R V+ CL L + TK + + + L+QL
Sbjct: 372 DPSQRL------VQNCLWTLRNLSDAATKQEGMEGL-----------------LGTLVQL 408
Query: 365 LKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLIN--LLSSKRDGAIANAATVL 422
L SD+ V AA L+NLT N N + GI+ L+ L + R+ A L
Sbjct: 409 LGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICAL 468
Query: 423 TNMAMQEPLRLNIQNHDIMH----AIISPLRSAN--TVVQSKAALAVTATACDVEARTEL 476
++ + QN +H ++ L + ++++ L C L
Sbjct: 469 RHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPAN-HAPL 527
Query: 477 RNSGGLEPLVELLRSKNDEVRKHAS 501
R G + LV+LL + + ++ S
Sbjct: 528 REQGAIPRLVQLLVRAHQDTQRRTS 552
Score = 54.3 bits (129), Expect = 5e-07
Identities = 99/441 (22%), Positives = 168/441 (38%), Gaps = 53/441 (12%)
Query: 30 VVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATM 89
+V ML SP + +L A ++ L E K + G ++ + LL + T
Sbjct: 240 LVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTD 299
Query: 90 IFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHE---------FASLCLANMSAEY 140
ILA N KL+ ++A P+ V I S L +S
Sbjct: 300 CLQILAYGNQESKLI--------ILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCS 351
Query: 141 TSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLL 200
++K I E GG++ L L+ P + +N + + NL + ++ L + ++ LL
Sbjct: 352 SNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGL--LGTLVQLL 409
Query: 201 KS-EYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIK-ILETKELNDLHIEALAVIA 258
S + V+ A + N+ +++ M+ G++ L++ +L + D+ A+ +
Sbjct: 410 GSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALR 469
Query: 259 NCLEDMDTMVQIQQTG-----GLKKLLSFAENSTIPDIQKNAAKAITKAAYDPENRKLFH 313
+ L ++ Q GL ++ + + K I A P N
Sbjct: 470 H-LTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLR 528
Query: 314 EQEVEKCLVALL--------------GSENDGTKIAASQAISAMCENS---GSKDFFNN- 355
EQ LV LL G++ + + I C + ++D N
Sbjct: 529 EQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRI 588
Query: 356 -----QGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGID-PLINLLSS 409
IP +QLL S E ++ AA L L A A EA+G PL LL S
Sbjct: 589 VIRGLNTIPLFVQLLYSPIENIQRVAAGVLCEL--AQDKEAAEAIEAEGATAPLTELLHS 646
Query: 410 KRDGAIANAATVLTNMAMQEP 430
+ +G AA VL M+ +P
Sbjct: 647 RNEGVATYAAAVLFRMSEDKP 667
Score = 45.1 bits (105), Expect = 3e-04
Identities = 72/354 (20%), Positives = 142/354 (40%), Gaps = 40/354 (11%)
Query: 59 NKTTLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNNDVKKLLRELDVMNSVIAQLA 118
NK ++E G ++ L LT + + +N L + +D ++ + + QL
Sbjct: 353 NKPAIVEAGGMQALGLHLTDPSQRLVQNCLWT---LRNLSDAATKQEGMEGLLGTLVQLL 409
Query: 119 PEEEVVIHEFASLCLANMSAE-YTSKVQIFEHGGLEPLIR--LLSSPDPDVKKNSMECIY 175
+++ + A+ L+N++ Y +K+ + + GG+E L+R L + D+ + ++ +
Sbjct: 410 GSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALR 469
Query: 176 NLVQDFQCRAKLQEL----NAIPPILDLLK--SEYPVIQLLALKTLGVIAN---DKESRT 226
+L Q Q +P ++ LL S +P+I+ T+G+I N +
Sbjct: 470 HLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKA----TVGLIRNLALCPANHA 525
Query: 227 MLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQ--TGGLKKLLSFAE 284
LR+ + L+++L + ++ + M +I + TG L L
Sbjct: 526 PLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVH 585
Query: 285 N------------------STIPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLG 326
N S I +IQ+ AA + + A D E + + L LL
Sbjct: 586 NRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLH 645
Query: 327 SENDGTKIAASQAISAMCENSGSKDFFNNQGIPQLIQLLKSDNEEVREAAALAL 380
S N+G A+ + M E+ +D+ + L +++ E A L L
Sbjct: 646 SRNEGVATYAAAVLFRMSEDK-PQDYKKRLSVELTSSLFRTEPMAWNETADLGL 698
Score = 35.8 bits (81), Expect = 0.18
Identities = 52/263 (19%), Positives = 102/263 (38%), Gaps = 29/263 (11%)
Query: 29 TVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPL--TKLLTHEDKIVRRN 86
T+V +L S + ++ A + +NK + ++G +E L T L + + +
Sbjct: 404 TLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEP 463
Query: 87 ATMIFGILASNNDVKKLLRELDVMNS----VIAQLAPEEEVVIHEFASLCLANMSAEYTS 142
A L S + ++ + ++ V+ L P + + + N++ +
Sbjct: 464 AICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPAN 523
Query: 143 KVQIFEHGGLEPLIRLLSSPDPDVKKNS--------------ME--------CIYNLVQD 180
+ E G + L++LL D ++ + ME ++ L +D
Sbjct: 524 HAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARD 583
Query: 181 FQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKI 240
R ++ LN IP + LL S IQ +A L +A DKE+ + L ++
Sbjct: 584 VHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTEL 643
Query: 241 LETKELNDLHIEALAVIANCLED 263
L ++ + A AV+ ED
Sbjct: 644 LHSRN-EGVATYAAAVLFRMSED 665
>gi|148233338 catenin (cadherin-associated protein), beta 1, 88kDa
[Homo sapiens]
Length = 781
Score = 67.0 bits (162), Expect = 7e-11
Identities = 88/445 (19%), Positives = 174/445 (39%), Gaps = 55/445 (12%)
Query: 68 AVEPLTKLLTHEDKIV-RRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIH 126
A+ LTKLL ED++V + A M+ + ++R ++++++ + +V
Sbjct: 152 AIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETA 211
Query: 127 EFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQ-CRA 185
+ L N+S + IF+ GG+ L+++L SP V ++ ++NL+ + +
Sbjct: 212 RCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKM 271
Query: 186 KLQELNAIPPILDLLKSEYPVIQLLALKTLGVIA-NDKESRTMLRDNQGLDHLIKILETK 244
++ + ++ LL + L ++A ++ES+ ++ + G L+ I+ T
Sbjct: 272 AVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTY 331
Query: 245 ELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAY 304
L + T + K+LS ++ ++ +A+
Sbjct: 332 TYEKL--------------------LWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLT 371
Query: 305 DPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIPQLIQL 364
DP R V+ CL L + TK + + + L+QL
Sbjct: 372 DPSQRL------VQNCLWTLRNLSDAATKQEGMEGL-----------------LGTLVQL 408
Query: 365 LKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLIN--LLSSKRDGAIANAATVL 422
L SD+ V AA L+NLT N N + GI+ L+ L + R+ A L
Sbjct: 409 LGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICAL 468
Query: 423 TNMAMQEPLRLNIQNHDIMH----AIISPLRSAN--TVVQSKAALAVTATACDVEARTEL 476
++ + QN +H ++ L + ++++ L C L
Sbjct: 469 RHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPAN-HAPL 527
Query: 477 RNSGGLEPLVELLRSKNDEVRKHAS 501
R G + LV+LL + + ++ S
Sbjct: 528 REQGAIPRLVQLLVRAHQDTQRRTS 552
Score = 54.3 bits (129), Expect = 5e-07
Identities = 99/441 (22%), Positives = 168/441 (38%), Gaps = 53/441 (12%)
Query: 30 VVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATM 89
+V ML SP + +L A ++ L E K + G ++ + LL + T
Sbjct: 240 LVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTD 299
Query: 90 IFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHE---------FASLCLANMSAEY 140
ILA N KL+ ++A P+ V I S L +S
Sbjct: 300 CLQILAYGNQESKLI--------ILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCS 351
Query: 141 TSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLL 200
++K I E GG++ L L+ P + +N + + NL + ++ L + ++ LL
Sbjct: 352 SNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGL--LGTLVQLL 409
Query: 201 KS-EYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIK-ILETKELNDLHIEALAVIA 258
S + V+ A + N+ +++ M+ G++ L++ +L + D+ A+ +
Sbjct: 410 GSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALR 469
Query: 259 NCLEDMDTMVQIQQTG-----GLKKLLSFAENSTIPDIQKNAAKAITKAAYDPENRKLFH 313
+ L ++ Q GL ++ + + K I A P N
Sbjct: 470 H-LTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLR 528
Query: 314 EQEVEKCLVALL--------------GSENDGTKIAASQAISAMCENS---GSKDFFNN- 355
EQ LV LL G++ + + I C + ++D N
Sbjct: 529 EQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRI 588
Query: 356 -----QGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGID-PLINLLSS 409
IP +QLL S E ++ AA L L A A EA+G PL LL S
Sbjct: 589 VIRGLNTIPLFVQLLYSPIENIQRVAAGVLCEL--AQDKEAAEAIEAEGATAPLTELLHS 646
Query: 410 KRDGAIANAATVLTNMAMQEP 430
+ +G AA VL M+ +P
Sbjct: 647 RNEGVATYAAAVLFRMSEDKP 667
Score = 45.1 bits (105), Expect = 3e-04
Identities = 72/354 (20%), Positives = 142/354 (40%), Gaps = 40/354 (11%)
Query: 59 NKTTLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNNDVKKLLRELDVMNSVIAQLA 118
NK ++E G ++ L LT + + +N L + +D ++ + + QL
Sbjct: 353 NKPAIVEAGGMQALGLHLTDPSQRLVQNCLWT---LRNLSDAATKQEGMEGLLGTLVQLL 409
Query: 119 PEEEVVIHEFASLCLANMSAE-YTSKVQIFEHGGLEPLIR--LLSSPDPDVKKNSMECIY 175
+++ + A+ L+N++ Y +K+ + + GG+E L+R L + D+ + ++ +
Sbjct: 410 GSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALR 469
Query: 176 NLVQDFQCRAKLQEL----NAIPPILDLLK--SEYPVIQLLALKTLGVIAN---DKESRT 226
+L Q Q +P ++ LL S +P+I+ T+G+I N +
Sbjct: 470 HLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKA----TVGLIRNLALCPANHA 525
Query: 227 MLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQ--TGGLKKLLSFAE 284
LR+ + L+++L + ++ + M +I + TG L L
Sbjct: 526 PLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVH 585
Query: 285 N------------------STIPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLG 326
N S I +IQ+ AA + + A D E + + L LL
Sbjct: 586 NRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLH 645
Query: 327 SENDGTKIAASQAISAMCENSGSKDFFNNQGIPQLIQLLKSDNEEVREAAALAL 380
S N+G A+ + M E+ +D+ + L +++ E A L L
Sbjct: 646 SRNEGVATYAAAVLFRMSEDK-PQDYKKRLSVELTSSLFRTEPMAWNETADLGL 698
Score = 35.8 bits (81), Expect = 0.18
Identities = 52/263 (19%), Positives = 102/263 (38%), Gaps = 29/263 (11%)
Query: 29 TVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPL--TKLLTHEDKIVRRN 86
T+V +L S + ++ A + +NK + ++G +E L T L + + +
Sbjct: 404 TLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEP 463
Query: 87 ATMIFGILASNNDVKKLLRELDVMNS----VIAQLAPEEEVVIHEFASLCLANMSAEYTS 142
A L S + ++ + ++ V+ L P + + + N++ +
Sbjct: 464 AICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPAN 523
Query: 143 KVQIFEHGGLEPLIRLLSSPDPDVKKNS--------------ME--------CIYNLVQD 180
+ E G + L++LL D ++ + ME ++ L +D
Sbjct: 524 HAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARD 583
Query: 181 FQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKI 240
R ++ LN IP + LL S IQ +A L +A DKE+ + L ++
Sbjct: 584 VHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTEL 643
Query: 241 LETKELNDLHIEALAVIANCLED 263
L ++ + A AV+ ED
Sbjct: 644 LHSRN-EGVATYAAAVLFRMSED 665
>gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa
[Homo sapiens]
Length = 781
Score = 67.0 bits (162), Expect = 7e-11
Identities = 88/445 (19%), Positives = 174/445 (39%), Gaps = 55/445 (12%)
Query: 68 AVEPLTKLLTHEDKIV-RRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIH 126
A+ LTKLL ED++V + A M+ + ++R ++++++ + +V
Sbjct: 152 AIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETA 211
Query: 127 EFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQ-CRA 185
+ L N+S + IF+ GG+ L+++L SP V ++ ++NL+ + +
Sbjct: 212 RCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKM 271
Query: 186 KLQELNAIPPILDLLKSEYPVIQLLALKTLGVIA-NDKESRTMLRDNQGLDHLIKILETK 244
++ + ++ LL + L ++A ++ES+ ++ + G L+ I+ T
Sbjct: 272 AVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTY 331
Query: 245 ELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAY 304
L + T + K+LS ++ ++ +A+
Sbjct: 332 TYEKL--------------------LWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLT 371
Query: 305 DPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIPQLIQL 364
DP R V+ CL L + TK + + + L+QL
Sbjct: 372 DPSQRL------VQNCLWTLRNLSDAATKQEGMEGL-----------------LGTLVQL 408
Query: 365 LKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLIN--LLSSKRDGAIANAATVL 422
L SD+ V AA L+NLT N N + GI+ L+ L + R+ A L
Sbjct: 409 LGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICAL 468
Query: 423 TNMAMQEPLRLNIQNHDIMH----AIISPLRSAN--TVVQSKAALAVTATACDVEARTEL 476
++ + QN +H ++ L + ++++ L C L
Sbjct: 469 RHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPAN-HAPL 527
Query: 477 RNSGGLEPLVELLRSKNDEVRKHAS 501
R G + LV+LL + + ++ S
Sbjct: 528 REQGAIPRLVQLLVRAHQDTQRRTS 552
Score = 54.3 bits (129), Expect = 5e-07
Identities = 99/441 (22%), Positives = 168/441 (38%), Gaps = 53/441 (12%)
Query: 30 VVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATM 89
+V ML SP + +L A ++ L E K + G ++ + LL + T
Sbjct: 240 LVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTD 299
Query: 90 IFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHE---------FASLCLANMSAEY 140
ILA N KL+ ++A P+ V I S L +S
Sbjct: 300 CLQILAYGNQESKLI--------ILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCS 351
Query: 141 TSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLL 200
++K I E GG++ L L+ P + +N + + NL + ++ L + ++ LL
Sbjct: 352 SNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGL--LGTLVQLL 409
Query: 201 KS-EYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIK-ILETKELNDLHIEALAVIA 258
S + V+ A + N+ +++ M+ G++ L++ +L + D+ A+ +
Sbjct: 410 GSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALR 469
Query: 259 NCLEDMDTMVQIQQTG-----GLKKLLSFAENSTIPDIQKNAAKAITKAAYDPENRKLFH 313
+ L ++ Q GL ++ + + K I A P N
Sbjct: 470 H-LTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLR 528
Query: 314 EQEVEKCLVALL--------------GSENDGTKIAASQAISAMCENS---GSKDFFNN- 355
EQ LV LL G++ + + I C + ++D N
Sbjct: 529 EQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRI 588
Query: 356 -----QGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGID-PLINLLSS 409
IP +QLL S E ++ AA L L A A EA+G PL LL S
Sbjct: 589 VIRGLNTIPLFVQLLYSPIENIQRVAAGVLCEL--AQDKEAAEAIEAEGATAPLTELLHS 646
Query: 410 KRDGAIANAATVLTNMAMQEP 430
+ +G AA VL M+ +P
Sbjct: 647 RNEGVATYAAAVLFRMSEDKP 667
Score = 45.1 bits (105), Expect = 3e-04
Identities = 72/354 (20%), Positives = 142/354 (40%), Gaps = 40/354 (11%)
Query: 59 NKTTLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNNDVKKLLRELDVMNSVIAQLA 118
NK ++E G ++ L LT + + +N L + +D ++ + + QL
Sbjct: 353 NKPAIVEAGGMQALGLHLTDPSQRLVQNCLWT---LRNLSDAATKQEGMEGLLGTLVQLL 409
Query: 119 PEEEVVIHEFASLCLANMSAE-YTSKVQIFEHGGLEPLIR--LLSSPDPDVKKNSMECIY 175
+++ + A+ L+N++ Y +K+ + + GG+E L+R L + D+ + ++ +
Sbjct: 410 GSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALR 469
Query: 176 NLVQDFQCRAKLQEL----NAIPPILDLLK--SEYPVIQLLALKTLGVIAN---DKESRT 226
+L Q Q +P ++ LL S +P+I+ T+G+I N +
Sbjct: 470 HLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKA----TVGLIRNLALCPANHA 525
Query: 227 MLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQ--TGGLKKLLSFAE 284
LR+ + L+++L + ++ + M +I + TG L L
Sbjct: 526 PLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVH 585
Query: 285 N------------------STIPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLG 326
N S I +IQ+ AA + + A D E + + L LL
Sbjct: 586 NRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLH 645
Query: 327 SENDGTKIAASQAISAMCENSGSKDFFNNQGIPQLIQLLKSDNEEVREAAALAL 380
S N+G A+ + M E+ +D+ + L +++ E A L L
Sbjct: 646 SRNEGVATYAAAVLFRMSEDK-PQDYKKRLSVELTSSLFRTEPMAWNETADLGL 698
Score = 35.8 bits (81), Expect = 0.18
Identities = 52/263 (19%), Positives = 102/263 (38%), Gaps = 29/263 (11%)
Query: 29 TVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPL--TKLLTHEDKIVRRN 86
T+V +L S + ++ A + +NK + ++G +E L T L + + +
Sbjct: 404 TLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEP 463
Query: 87 ATMIFGILASNNDVKKLLRELDVMNS----VIAQLAPEEEVVIHEFASLCLANMSAEYTS 142
A L S + ++ + ++ V+ L P + + + N++ +
Sbjct: 464 AICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPAN 523
Query: 143 KVQIFEHGGLEPLIRLLSSPDPDVKKNS--------------ME--------CIYNLVQD 180
+ E G + L++LL D ++ + ME ++ L +D
Sbjct: 524 HAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARD 583
Query: 181 FQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKI 240
R ++ LN IP + LL S IQ +A L +A DKE+ + L ++
Sbjct: 584 VHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTEL 643
Query: 241 LETKELNDLHIEALAVIANCLED 263
L ++ + A AV+ ED
Sbjct: 644 LHSRN-EGVATYAAAVLFRMSED 665
>gi|28875784 armadillo repeat containing 5 isoform b [Homo sapiens]
Length = 725
Score = 59.3 bits (142), Expect = 1e-08
Identities = 58/248 (23%), Positives = 109/248 (43%), Gaps = 10/248 (4%)
Query: 253 ALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPENRKLF 312
AL+++A+C + ++++ GG+ L++ + IQ A+A+ A +PE+
Sbjct: 132 ALSILADCCTEGACRTEVRRLGGILPLVTILQCMKTDSIQNRTARALGNLAMEPESCGDI 191
Query: 313 HEQEVEKCLVALLGSENDGTKI-AASQAISAMCENSGSKDFFNNQG-IPQLIQLLKSDNE 370
H LV L + D + + +A+ + ++ + QG + L +LL + +
Sbjct: 192 HCAGAVPLLVESLTACQDSQCLQSVVRALRNLADSPQHRLALAQQGAVRPLAELLATAPD 251
Query: 371 EVREAAAL-ALANLTT-CNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNMAMQ 428
A + AL L+ C+ A A + G+ PL++L S + +L N+ Q
Sbjct: 252 AALTLALVRALLELSRGCSRACAEQLSLGGGLGPLVSLASHPKRAVREGTILILANLCAQ 311
Query: 429 EPLRLNIQNHDIMHAIISPLR------SANTVVQSKAALAVTATACDVEARTELRNSGGL 482
+R + N + ++ LR A+ Q AV + R LR++GGL
Sbjct: 312 GLIRPALGNAGGVEVLVDELRQRRDPNGASPTSQQPLVRAVCLLCREAINRARLRDAGGL 371
Query: 483 EPLVELLR 490
+ L+ LLR
Sbjct: 372 DLLMGLLR 379
Score = 44.7 bits (104), Expect = 4e-04
Identities = 36/163 (22%), Positives = 67/163 (41%), Gaps = 6/163 (3%)
Query: 118 APEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNL 177
AP+ + + +L + Q+ GGL PL+ L S P V++ ++ + NL
Sbjct: 249 APDAALTLALVRALLELSRGCSRACAEQLSLGGGLGPLVSLASHPKRAVREGTILILANL 308
Query: 178 VQDFQCRAKLQELNAIPPILDLLKSEY------PVIQLLALKTLGVIANDKESRTMLRDN 231
R L + ++D L+ P Q ++ + ++ + +R LRD
Sbjct: 309 CAQGLIRPALGNAGGVEVLVDELRQRRDPNGASPTSQQPLVRAVCLLCREAINRARLRDA 368
Query: 232 QGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTG 274
GLD L+ +L + H +A + L D + ++Q G
Sbjct: 369 GGLDLLMGLLRDPRASAWHPRIVAALVGFLYDTGALGRLQALG 411
Score = 33.1 bits (74), Expect = 1.2
Identities = 38/170 (22%), Positives = 66/170 (38%), Gaps = 7/170 (4%)
Query: 361 LIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDG-AIANAA 419
++Q +K+D+ ++ A AL NL P + A + L+ L++ +D + +
Sbjct: 161 ILQCMKTDS--IQNRTARALGNLAM-EPESCGDIHCAGAVPLLVESLTACQDSQCLQSVV 217
Query: 420 TVLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKA---ALAVTATACDVEARTEL 476
L N+A RL + + + L +A + A AL + C +L
Sbjct: 218 RALRNLADSPQHRLALAQQGAVRPLAELLATAPDAALTLALVRALLELSRGCSRACAEQL 277
Query: 477 RNSGGLEPLVELLRSKNDEVRKHASWAVMVCAGDELTANELCRLGALDIL 526
GGL PLV L VR+ + L L G +++L
Sbjct: 278 SLGGGLGPLVSLASHPKRAVREGTILILANLCAQGLIRPALGNAGGVEVL 327
>gi|157426856 armadillo repeat containing 5 isoform a [Homo sapiens]
Length = 935
Score = 59.3 bits (142), Expect = 1e-08
Identities = 58/248 (23%), Positives = 109/248 (43%), Gaps = 10/248 (4%)
Query: 253 ALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPENRKLF 312
AL+++A+C + ++++ GG+ L++ + IQ A+A+ A +PE+
Sbjct: 132 ALSILADCCTEGACRTEVRRLGGILPLVTILQCMKTDSIQNRTARALGNLAMEPESCGDI 191
Query: 313 HEQEVEKCLVALLGSENDGTKI-AASQAISAMCENSGSKDFFNNQG-IPQLIQLLKSDNE 370
H LV L + D + + +A+ + ++ + QG + L +LL + +
Sbjct: 192 HCAGAVPLLVESLTACQDSQCLQSVVRALRNLADSPQHRLALAQQGAVRPLAELLATAPD 251
Query: 371 EVREAAAL-ALANLTT-CNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNMAMQ 428
A + AL L+ C+ A A + G+ PL++L S + +L N+ Q
Sbjct: 252 AALTLALVRALLELSRGCSRACAEQLSLGGGLGPLVSLASHPKRAVREGTILILANLCAQ 311
Query: 429 EPLRLNIQNHDIMHAIISPLR------SANTVVQSKAALAVTATACDVEARTELRNSGGL 482
+R + N + ++ LR A+ Q AV + R LR++GGL
Sbjct: 312 GLIRPALGNAGGVEVLVDELRQRRDPNGASPTSQQPLVRAVCLLCREAINRARLRDAGGL 371
Query: 483 EPLVELLR 490
+ L+ LLR
Sbjct: 372 DLLMGLLR 379
Score = 44.7 bits (104), Expect = 4e-04
Identities = 36/163 (22%), Positives = 67/163 (41%), Gaps = 6/163 (3%)
Query: 118 APEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNL 177
AP+ + + +L + Q+ GGL PL+ L S P V++ ++ + NL
Sbjct: 249 APDAALTLALVRALLELSRGCSRACAEQLSLGGGLGPLVSLASHPKRAVREGTILILANL 308
Query: 178 VQDFQCRAKLQELNAIPPILDLLKSEY------PVIQLLALKTLGVIANDKESRTMLRDN 231
R L + ++D L+ P Q ++ + ++ + +R LRD
Sbjct: 309 CAQGLIRPALGNAGGVEVLVDELRQRRDPNGASPTSQQPLVRAVCLLCREAINRARLRDA 368
Query: 232 QGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTG 274
GLD L+ +L + H +A + L D + ++Q G
Sbjct: 369 GGLDLLMGLLRDPRASAWHPRIVAALVGFLYDTGALGRLQALG 411
Score = 33.1 bits (74), Expect = 1.2
Identities = 38/170 (22%), Positives = 66/170 (38%), Gaps = 7/170 (4%)
Query: 361 LIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDG-AIANAA 419
++Q +K+D+ ++ A AL NL P + A + L+ L++ +D + +
Sbjct: 161 ILQCMKTDS--IQNRTARALGNLAM-EPESCGDIHCAGAVPLLVESLTACQDSQCLQSVV 217
Query: 420 TVLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKA---ALAVTATACDVEARTEL 476
L N+A RL + + + L +A + A AL + C +L
Sbjct: 218 RALRNLADSPQHRLALAQQGAVRPLAELLATAPDAALTLALVRALLELSRGCSRACAEQL 277
Query: 477 RNSGGLEPLVELLRSKNDEVRKHASWAVMVCAGDELTANELCRLGALDIL 526
GGL PLV L VR+ + L L G +++L
Sbjct: 278 SLGGGLGPLVSLASHPKRAVREGTILILANLCAQGLIRPALGNAGGVEVL 327
>gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2
[Homo sapiens]
Length = 607
Score = 58.9 bits (141), Expect = 2e-08
Identities = 81/354 (22%), Positives = 155/354 (43%), Gaps = 37/354 (10%)
Query: 60 KTTLLELGAVEPLTKLLTH------EDKI--VRRNATMIFGILASNNDVKKLLR--ELDV 109
K L+E G VE L +++ ED I ++ + ++ +L + ++KL + V
Sbjct: 259 KLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSV 318
Query: 110 MNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPD---- 165
V++ + P + +L +AN + + + + ++G +E L+ LL D
Sbjct: 319 FQRVLSWI-PSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVEDGNVT 377
Query: 166 VKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESR 225
V+ ++ + NL +AK+ +L LKSE P +Q L TL ++ + +E+
Sbjct: 378 VQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQEAA 437
Query: 226 TMLRDNQGL-DHLIKILETKELNDLHIEA---LAVIANCLEDMDTMVQIQQTGGLKKLLS 281
L N L + L++ E K+ + E+ L+ + + D + I Q+GG+K L++
Sbjct: 438 EQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKDVIKTIVQSGGIKHLVT 497
Query: 282 FA-------ENSTIPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKI 334
A +N + + AA + A D E+ KL + L LL E +I
Sbjct: 498 MATSEHVIMQNEALVALALIAALELGTAEKDLESAKLV------QILHRLLADERSAPEI 551
Query: 335 AASQAISAMCENSGS----KDFFNNQGIPQLIQLLKSDNEEVREAAALALANLT 384
+ + +C GS K+ + + + +L +N+ V + A+L LT
Sbjct: 552 KYNSMV-LICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQRLT 604
Score = 43.9 bits (102), Expect = 7e-04
Identities = 96/532 (18%), Positives = 219/532 (41%), Gaps = 58/532 (10%)
Query: 22 IESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELG----AVEPLTKLLT 77
+++ + +V +LNS ++E+L + A+ E ++ + + G ++ L L +
Sbjct: 87 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCS 146
Query: 78 HEDKIVRRNATMIFGILAS----NNDVKKLLRELDVMNSVIAQLAPE-EEVVIHEFASLC 132
D + T+ G+L + N+ ++ L + V+ +++ L + + E +
Sbjct: 147 ITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVA 206
Query: 133 LANMSAEYTSKVQIFEHGGLEPLIRLLSSP-DPDVKKNSMECIYNLVQDFQCRAKLQELN 191
N++ +SK Q E L++L + D ++ E + L ++ + +L E
Sbjct: 207 FGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAG 266
Query: 192 AIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKILETKELNDLHI 251
+ +L++++ + + +DKE I E K +DL +
Sbjct: 267 LVECLLEIVQQK--------------VDSDKED--------------DITELKTGSDLMV 298
Query: 252 EALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPEN-RK 310
L ++ + E M + + + +++LS+ ++ +Q A AI A + N
Sbjct: 299 --LLLLGD--ESMQKLFEGGKGSVFQRVLSWIPSNN-HQLQLAGALAIANFARNDANCIH 353
Query: 311 LFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENS---GSKDFFNNQGIPQ-LIQLLK 366
+ VEK + L DG A+SA+ + +K + G+ + +++ LK
Sbjct: 354 MVDNGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLK 413
Query: 367 SDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIAN-----AATV 421
S+ V+ L L A ++ L+ +K + + +
Sbjct: 414 SEMPPVQFKLLGTLRMLIDAQEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSAL 473
Query: 422 LTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKA--ALAVTATACDVEARTELRNS 479
+ + ++ ++ +Q+ I H +++ S + ++Q++A ALA+ A A +L ++
Sbjct: 474 IRHSKSKDVIKTIVQSGGIKH-LVTMATSEHVIMQNEALVALALIAALELGTAEKDLESA 532
Query: 480 GGLEPLVELLRSKNDEVRKHASWAVMVCA--GDELTANELCRLGALDILEEV 529
++ L LL + + V++CA G E E+ L LD++ ++
Sbjct: 533 KLVQILHRLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKL 584
>gi|39812229 karyopherin alpha 5 [Homo sapiens]
Length = 539
Score = 57.0 bits (136), Expect = 7e-08
Identities = 84/374 (22%), Positives = 147/374 (39%), Gaps = 47/374 (12%)
Query: 119 PEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLS-SPDPDVKK--------- 168
PEEEVV + + +N + + + Q F +LLS P+P + +
Sbjct: 79 PEEEVVTTDMVQMIFSNNADQQLTATQKFR--------KLLSKEPNPPIDQVIQKPGVVQ 130
Query: 169 ---NSMECIYNLVQDFQCRAKLQ--------------ELNAIPPILDLLKSEYPVIQLLA 211
+E N F+ L E A+P + LL SE+ +Q A
Sbjct: 131 RFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQA 190
Query: 212 LKTLGVIANDK-ESRTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQI 270
+ LG IA D E R + + + L L+++L A+ ++N +
Sbjct: 191 VWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNF 250
Query: 271 QQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPENR-KLFHEQEVEKCLVALLGSEN 329
+ +LS S+ PD+ + A++ + P ++ + + V + LV LL +
Sbjct: 251 SKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHND 310
Query: 330 DGTKIAASQAISAMC--ENSGSKDFFNNQGIPQLIQLLKSDNEEVREAAALALANLTTCN 387
A +A+ + ++ ++ N +P L+ LL S E +R+ A ++N+T N
Sbjct: 311 YKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGN 370
Query: 388 PANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNM---AMQEPLRLNIQNHDIMHAI 444
A A +A+ LI +L AA +TN E +R + +
Sbjct: 371 RAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIR-----YLVALGC 425
Query: 445 ISPLRSANTVVQSK 458
I PL TV+ SK
Sbjct: 426 IKPLCDLLTVMDSK 439
Score = 52.8 bits (125), Expect = 1e-06
Identities = 64/268 (23%), Positives = 117/268 (43%), Gaps = 9/268 (3%)
Query: 270 IQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPE-NRKLFHEQEVEKCLVALLGSE 328
IQ+ G +++ + F E + +Q AA A+T A + K+ E + LL SE
Sbjct: 123 IQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSE 182
Query: 329 NDGTKIAASQAISAMC-ENSGSKDF-FNNQGIPQLIQLLKSDNE-EVREAAALALANLTT 385
++ + A A+ + +N+ +DF N + +P L++LL + N A AL+NL
Sbjct: 183 HEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCR 242
Query: 386 CNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNMAMQEPLRLN-IQNHDIMHAI 444
N + + ++ L LL S +A+ L+ ++ ++ + + + +
Sbjct: 243 GKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRL 302
Query: 445 ISPLRSANTVVQSKAALAV--TATACDVEARTELRNSGGLEPLVELLRSKNDEVRKHASW 502
+ L + V S A AV T D++ + L N L L+ LL S + +RK A W
Sbjct: 303 VELLMHNDYKVVSPALRAVGNIVTGDDIQTQVIL-NCSALPCLLHLLSSPKESIRKEACW 361
Query: 503 AVM-VCAGDELTANELCRLGALDILEEV 529
V + AG+ + +L E+
Sbjct: 362 TVSNITAGNRAQIQAVIDANIFPVLIEI 389
Score = 43.9 bits (102), Expect = 7e-04
Identities = 64/279 (22%), Positives = 111/279 (39%), Gaps = 10/279 (3%)
Query: 234 LDHLIKILETKELNDLHIEALAVIANCLED--MDTMVQIQQTGGLKKLLSFAENSTIPDI 291
+ +K LE E L EA + N + T V I+ TG + + NS D+
Sbjct: 129 VQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIE-TGAVPIFIKLL-NSEHEDV 186
Query: 292 QKNAAKAITKAAYD-PENRKLFHEQEVEKCLVALLGSENDGTKIA-ASQAISAMCENSGS 349
Q+ A A+ A D E R E+ L+ LL + N T A A+S +C
Sbjct: 187 QEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNP 246
Query: 350 KDFFNNQG--IPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLL 407
F+ + L +LL S + +V AL+ L+ A ++ L+ LL
Sbjct: 247 PPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELL 306
Query: 408 SSKRDGAIANAATVLTNMAMQEPLRLN-IQNHDIMHAIISPLRSANTVVQSKAALAVTAT 466
++ A + N+ + ++ I N + ++ L S ++ +A V+
Sbjct: 307 MHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNI 366
Query: 467 ACDVEARTELRNSGGLEP-LVELLRSKNDEVRKHASWAV 504
A+ + + P L+E+L+ RK A+WA+
Sbjct: 367 TAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAI 405
Score = 42.4 bits (98), Expect = 0.002
Identities = 54/236 (22%), Positives = 104/236 (44%), Gaps = 6/236 (2%)
Query: 297 KAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENS--GSKDFFN 354
K ++K P ++ + V++ + L +EN + A+ A++ + + +K
Sbjct: 109 KLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIE 168
Query: 355 NQGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLL-SSKRDG 413
+P I+LL S++E+V+E A AL N+ N + + + PL+ LL +S R
Sbjct: 169 TGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLT 228
Query: 414 AIANAATVLTNMAMQEPLRLNIQN-HDIMHAIISPLRSANTVVQSKAALAVTATACDVEA 472
NA L+N+ + N ++ + L S++ V + A++ +
Sbjct: 229 TTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPND 288
Query: 473 RTE-LRNSGGLEPLVELLRSKNDEVRKHASWAV-MVCAGDELTANELCRLGALDIL 526
+ + + +SG LVELL + +V A AV + GD++ + AL L
Sbjct: 289 KIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCL 344
Score = 38.5 bits (88), Expect = 0.027
Identities = 54/242 (22%), Positives = 107/242 (44%), Gaps = 20/242 (8%)
Query: 33 MLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATMIFG 92
+L S + ++LA C A+ + + +++ G L +LL H D V A G
Sbjct: 263 LLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVG 322
Query: 93 ILASNNDVK-KLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGG 151
+ + +D++ +++ + ++ L+ +E + E A ++N++A +++Q
Sbjct: 323 NIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKE-ACWTVSNITAGNRAQIQAVIDAN 381
Query: 152 LEP-LIRLLSSPDPDVKKNSMECIYNLVQ---DFQCRAKLQELNAIPPILDLLKSEYPVI 207
+ P LI +L + +K + I N Q R L L I P+ DLL I
Sbjct: 382 IFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIR-YLVALGCIKPLCDLLTVMDSKI 440
Query: 208 QLLALKTLGVI--ANDKESR----------TMLRDNQGLDHLIKILETKELNDLHIEALA 255
+AL L I ++ES+ ++ + GLD I+ L++ E +++ +A
Sbjct: 441 VQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDK-IEFLQSHENQEIYQKAFD 499
Query: 256 VI 257
+I
Sbjct: 500 LI 501
Score = 33.9 bits (76), Expect = 0.67
Identities = 72/323 (22%), Positives = 125/323 (38%), Gaps = 42/323 (13%)
Query: 3 KKIKKEVEPPPKDVFDPLMIESKKAATVVLMLNSPEEEILA-KACEAIYKFALKGEENKT 61
+K +K + P D ++ + V L E L +A A+ A +
Sbjct: 105 QKFRKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTK 164
Query: 62 TLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNN-DVKKLLRELDVMNSVIAQLAPE 120
++E GAV KLL E + V+ A G +A +N + + + +++ ++ L
Sbjct: 165 VVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNS 224
Query: 121 EEV-----VIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDV--------- 166
+ + ++LC SKV L L RLL S DPDV
Sbjct: 225 NRLTTTRNAVWALSNLCRGKNPPPNFSKVS----PCLNVLSRLLFSSDPDVLADVCWALS 280
Query: 167 --KKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLG-VIANDKE 223
+ I ++ CR +L EL L+ ++Y V+ AL+ +G ++ D
Sbjct: 281 YLSDGPNDKIQAVIDSGVCR-RLVEL--------LMHNDYKVVS-PALRAVGNIVTGDDI 330
Query: 224 SRTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGG----LKKL 279
++ + L L+ +L + + + EA ++N +Q L ++
Sbjct: 331 QTQVILNCSALPCLLHLLSSPK-ESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEI 389
Query: 280 LSFAENSTIPDIQKNAAKAITKA 302
L AE T +K AA AIT A
Sbjct: 390 LQKAEFRT----RKEAAWAITNA 408
>gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5
[Homo sapiens]
Length = 558
Score = 54.7 bits (130), Expect = 4e-07
Identities = 99/477 (20%), Positives = 198/477 (41%), Gaps = 50/477 (10%)
Query: 22 IESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLL-TH-E 79
+++ + +V +LNS ++E+L + A+ + L+ +G + L KLL H +
Sbjct: 86 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQ 145
Query: 80 DKIVRRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAE 139
+ + + FG LA K+ ++ ++ + E E LA ++
Sbjct: 146 NAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAEN 205
Query: 140 YTSKVQIFEHGGLEPLIRLL-----SSPDPDVK--KNSMECIYNLVQDFQCRAKLQE--- 189
K+Q+ E G +E L+ ++ S + D+ K + + L+ + KL E
Sbjct: 206 DAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGK 265
Query: 190 LNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKILETKELNDL 249
+ +L + S +QL + A + + + DN ++ L+ +L+ + + D
Sbjct: 266 GSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLD-RHVEDG 324
Query: 250 HI----EALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIP-------------DIQ 292
++ AL+ + N + ++ G + +L F ++ P D Q
Sbjct: 325 NVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQ 384
Query: 293 KNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKD- 351
AA+ + K N KL E+ VE C ++ G +++ +SA+ +S SKD
Sbjct: 385 AEAAEQLGK------NVKLV-ERLVEWC----EAKDHAGVMGESNRLLSALIRHSKSKDV 433
Query: 352 ---FFNNQGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAE-ADGIDPLINLL 407
+ GI L+ + S++ ++ A +ALA + A E A + L LL
Sbjct: 434 IKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRLL 493
Query: 408 SSKRDGAIA--NAATVLTNMAMQEPLRLNIQNHDIMHAIISPLRS-ANTVVQSKAAL 461
+ +R N+ ++ + E L +Q+ + ++S LRS N V +A+L
Sbjct: 494 ADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLD-VVSKLRSHENKSVAQQASL 549
>gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4
[Homo sapiens]
Length = 559
Score = 54.7 bits (130), Expect = 4e-07
Identities = 99/477 (20%), Positives = 198/477 (41%), Gaps = 50/477 (10%)
Query: 22 IESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLL-TH-E 79
+++ + +V +LNS ++E+L + A+ + L+ +G + L KLL H +
Sbjct: 87 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQ 146
Query: 80 DKIVRRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAE 139
+ + + FG LA K+ ++ ++ + E E LA ++
Sbjct: 147 NAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAEN 206
Query: 140 YTSKVQIFEHGGLEPLIRLL-----SSPDPDVK--KNSMECIYNLVQDFQCRAKLQE--- 189
K+Q+ E G +E L+ ++ S + D+ K + + L+ + KL E
Sbjct: 207 DAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGK 266
Query: 190 LNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKILETKELNDL 249
+ +L + S +QL + A + + + DN ++ L+ +L+ + + D
Sbjct: 267 GSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLD-RHVEDG 325
Query: 250 HI----EALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIP-------------DIQ 292
++ AL+ + N + ++ G + +L F ++ P D Q
Sbjct: 326 NVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQ 385
Query: 293 KNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKD- 351
AA+ + K N KL E+ VE C ++ G +++ +SA+ +S SKD
Sbjct: 386 AEAAEQLGK------NVKLV-ERLVEWC----EAKDHAGVMGESNRLLSALIRHSKSKDV 434
Query: 352 ---FFNNQGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAE-ADGIDPLINLL 407
+ GI L+ + S++ ++ A +ALA + A E A + L LL
Sbjct: 435 IKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRLL 494
Query: 408 SSKRDGAIA--NAATVLTNMAMQEPLRLNIQNHDIMHAIISPLRS-ANTVVQSKAAL 461
+ +R N+ ++ + E L +Q+ + ++S LRS N V +A+L
Sbjct: 495 ADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLD-VVSKLRSHENKSVAQQASL 550
>gi|155030202 RAP1, GTP-GDP dissociation stimulator 1 isoform 6
[Homo sapiens]
Length = 516
Score = 54.3 bits (129), Expect = 5e-07
Identities = 81/355 (22%), Positives = 154/355 (43%), Gaps = 38/355 (10%)
Query: 60 KTTLLELGAVEPLTKLLTH------EDKI--VRRNATMIFGILASNNDVKKLLR--ELDV 109
K L+E G VE L +++ ED I ++ + ++ +L + ++KL + V
Sbjct: 167 KLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSV 226
Query: 110 MNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPD---- 165
V++ + P + +L +AN + + + + ++G +E L+ LL D
Sbjct: 227 FQRVLSWI-PSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVEDGNVT 285
Query: 166 VKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIAN-DKES 224
V+ ++ + NL +AK+ +L LKSE P +Q L TL ++ + E+
Sbjct: 286 VQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQAEA 345
Query: 225 RTMLRDNQGL-DHLIKILETKELNDLHIEA---LAVIANCLEDMDTMVQIQQTGGLKKLL 280
L N L + L++ E K+ + E+ L+ + + D + I Q+GG+K L+
Sbjct: 346 AEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKDVIKTIVQSGGIKHLV 405
Query: 281 SFA-------ENSTIPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTK 333
+ A +N + + AA + A D E+ KL + L LL E +
Sbjct: 406 TMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLV------QILHRLLADERSAPE 459
Query: 334 IAASQAISAMCENSGS----KDFFNNQGIPQLIQLLKSDNEEVREAAALALANLT 384
I + + +C GS K+ + + + +L +N+ V + A+L LT
Sbjct: 460 IKYNSMV-LICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQRLT 513
>gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3
[Homo sapiens]
Length = 607
Score = 54.3 bits (129), Expect = 5e-07
Identities = 81/355 (22%), Positives = 154/355 (43%), Gaps = 38/355 (10%)
Query: 60 KTTLLELGAVEPLTKLLTH------EDKI--VRRNATMIFGILASNNDVKKLLR--ELDV 109
K L+E G VE L +++ ED I ++ + ++ +L + ++KL + V
Sbjct: 258 KLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSV 317
Query: 110 MNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPD---- 165
V++ + P + +L +AN + + + + ++G +E L+ LL D
Sbjct: 318 FQRVLSWI-PSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVEDGNVT 376
Query: 166 VKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIAN-DKES 224
V+ ++ + NL +AK+ +L LKSE P +Q L TL ++ + E+
Sbjct: 377 VQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQAEA 436
Query: 225 RTMLRDNQGL-DHLIKILETKELNDLHIEA---LAVIANCLEDMDTMVQIQQTGGLKKLL 280
L N L + L++ E K+ + E+ L+ + + D + I Q+GG+K L+
Sbjct: 437 AEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKDVIKTIVQSGGIKHLV 496
Query: 281 SFA-------ENSTIPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTK 333
+ A +N + + AA + A D E+ KL + L LL E +
Sbjct: 497 TMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLV------QILHRLLADERSAPE 550
Query: 334 IAASQAISAMCENSGS----KDFFNNQGIPQLIQLLKSDNEEVREAAALALANLT 384
I + + +C GS K+ + + + +L +N+ V + A+L LT
Sbjct: 551 IKYNSMV-LICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQRLT 604
Score = 41.6 bits (96), Expect = 0.003
Identities = 98/535 (18%), Positives = 219/535 (40%), Gaps = 63/535 (11%)
Query: 22 IESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELG----AVEPLTKLLT 77
+++ + +V +LNS ++E+L + A+ E ++ + + G ++ L L +
Sbjct: 86 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCS 145
Query: 78 HEDKIVRRNATMIFGILAS----NNDVKKLLRELDVMNSVIAQLAPE-EEVVIHEFASLC 132
D + T+ G+L + N+ ++ L + V+ +++ L + + E +
Sbjct: 146 ITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVA 205
Query: 133 LANMSAEYTSKVQIFEHGGLEPLIRLLSSP-DPDVKKNSMECIYNLVQDFQCRAKLQELN 191
N++ +SK Q E L++L + D ++ E + L ++ + +L E
Sbjct: 206 FGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAG 265
Query: 192 AIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKILETKELNDLHI 251
+ +L++++ + + +DKE I E K +DL +
Sbjct: 266 LVECLLEIVQQK--------------VDSDKED--------------DITELKTGSDLMV 297
Query: 252 EALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPEN-RK 310
L ++ + E M + + + +++LS+ ++ +Q A AI A + N
Sbjct: 298 --LLLLGD--ESMQKLFEGGKGSVFQRVLSWIPSNN-HQLQLAGALAIANFARNDANCIH 352
Query: 311 LFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENS---GSKDFFNNQGIPQLIQLLKS 367
+ VEK + L DG A+SA+ + +K + G+ + + LK
Sbjct: 353 MVDNGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAV--LKF 410
Query: 368 DNEEVREAAALALANLTTCNPANANAAAEADG----IDPLINLLSSKRDGAIAN-----A 418
E+ L L A A AA + ++ L+ +K +
Sbjct: 411 LKSEMPPVQFKLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLL 470
Query: 419 ATVLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKA--ALAVTATACDVEARTEL 476
+ ++ + ++ ++ +Q+ I H +++ S + ++Q++A ALA+ A A +L
Sbjct: 471 SALIRHSKSKDVIKTIVQSGGIKH-LVTMATSEHVIMQNEALVALALIAALELGTAEKDL 529
Query: 477 RNSGGLEPLVELLRSKNDEVRKHASWAVMVCA--GDELTANELCRLGALDILEEV 529
++ ++ L LL + + V++CA G E E+ L LD++ ++
Sbjct: 530 ESAKLVQILHRLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKL 584
>gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1
[Homo sapiens]
Length = 608
Score = 54.3 bits (129), Expect = 5e-07
Identities = 81/355 (22%), Positives = 154/355 (43%), Gaps = 38/355 (10%)
Query: 60 KTTLLELGAVEPLTKLLTH------EDKI--VRRNATMIFGILASNNDVKKLLR--ELDV 109
K L+E G VE L +++ ED I ++ + ++ +L + ++KL + V
Sbjct: 259 KLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSV 318
Query: 110 MNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPD---- 165
V++ + P + +L +AN + + + + ++G +E L+ LL D
Sbjct: 319 FQRVLSWI-PSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVEDGNVT 377
Query: 166 VKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIAN-DKES 224
V+ ++ + NL +AK+ +L LKSE P +Q L TL ++ + E+
Sbjct: 378 VQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQAEA 437
Query: 225 RTMLRDNQGL-DHLIKILETKELNDLHIEA---LAVIANCLEDMDTMVQIQQTGGLKKLL 280
L N L + L++ E K+ + E+ L+ + + D + I Q+GG+K L+
Sbjct: 438 AEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKDVIKTIVQSGGIKHLV 497
Query: 281 SFA-------ENSTIPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTK 333
+ A +N + + AA + A D E+ KL + L LL E +
Sbjct: 498 TMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLV------QILHRLLADERSAPE 551
Query: 334 IAASQAISAMCENSGS----KDFFNNQGIPQLIQLLKSDNEEVREAAALALANLT 384
I + + +C GS K+ + + + +L +N+ V + A+L LT
Sbjct: 552 IKYNSMV-LICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQRLT 605
Score = 41.6 bits (96), Expect = 0.003
Identities = 98/535 (18%), Positives = 219/535 (40%), Gaps = 63/535 (11%)
Query: 22 IESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELG----AVEPLTKLLT 77
+++ + +V +LNS ++E+L + A+ E ++ + + G ++ L L +
Sbjct: 87 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCS 146
Query: 78 HEDKIVRRNATMIFGILAS----NNDVKKLLRELDVMNSVIAQLAPE-EEVVIHEFASLC 132
D + T+ G+L + N+ ++ L + V+ +++ L + + E +
Sbjct: 147 ITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVA 206
Query: 133 LANMSAEYTSKVQIFEHGGLEPLIRLLSSP-DPDVKKNSMECIYNLVQDFQCRAKLQELN 191
N++ +SK Q E L++L + D ++ E + L ++ + +L E
Sbjct: 207 FGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAG 266
Query: 192 AIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKILETKELNDLHI 251
+ +L++++ + + +DKE I E K +DL +
Sbjct: 267 LVECLLEIVQQK--------------VDSDKED--------------DITELKTGSDLMV 298
Query: 252 EALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPEN-RK 310
L ++ + E M + + + +++LS+ ++ +Q A AI A + N
Sbjct: 299 --LLLLGD--ESMQKLFEGGKGSVFQRVLSWIPSNN-HQLQLAGALAIANFARNDANCIH 353
Query: 311 LFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENS---GSKDFFNNQGIPQLIQLLKS 367
+ VEK + L DG A+SA+ + +K + G+ + + LK
Sbjct: 354 MVDNGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAV--LKF 411
Query: 368 DNEEVREAAALALANLTTCNPANANAAAEADG----IDPLINLLSSKRDGAIAN-----A 418
E+ L L A A AA + ++ L+ +K +
Sbjct: 412 LKSEMPPVQFKLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLL 471
Query: 419 ATVLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKA--ALAVTATACDVEARTEL 476
+ ++ + ++ ++ +Q+ I H +++ S + ++Q++A ALA+ A A +L
Sbjct: 472 SALIRHSKSKDVIKTIVQSGGIKH-LVTMATSEHVIMQNEALVALALIAALELGTAEKDL 530
Query: 477 RNSGGLEPLVELLRSKNDEVRKHASWAVMVCA--GDELTANELCRLGALDILEEV 529
++ ++ L LL + + V++CA G E E+ L LD++ ++
Sbjct: 531 ESAKLVQILHRLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKL 585
>gi|4502247 armadillo repeat protein [Homo sapiens]
Length = 962
Score = 54.3 bits (129), Expect = 5e-07
Identities = 56/194 (28%), Positives = 87/194 (44%), Gaps = 23/194 (11%)
Query: 321 LVALLGSENDGTKIAASQAISAMC-ENSGSKDFFNN-QGIPQLIQLLKSDNEEVREAAAL 378
++A+L D K A+ + +C EN G K +G+P L+ LL EVR A
Sbjct: 363 VLAMLRHPVDPVKANAAAYLQHLCFENEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACG 422
Query: 379 ALANLTTCNPANANAA-AEADGIDPLINLLSSKRDGAIANAAT-VLTNMAMQEPLRLNIQ 436
AL NL+ + AA + G+ L+ LL + RD + T L N++ EPL++ I
Sbjct: 423 ALRNLSYGRDTDNKAAIRDCGGVPALVRLLRAARDNEVRELVTGTLWNLSSYEPLKMVII 482
Query: 437 NHDIM---HAIISP----LRSAN-----------TVVQSKAALAVTATACDVEARTELRN 478
+H + H +I P R N TV ++ + ++ EAR LR
Sbjct: 483 DHGLQTLTHEVIVPHSGWEREPNEDSKPRDAEWTTVFKNTSGCLRNVSSDGAEARRRLRE 542
Query: 479 SGGL-EPLVELLRS 491
GL + L+ L+S
Sbjct: 543 CEGLVDALLHALQS 556
Score = 47.8 bits (112), Expect = 5e-05
Identities = 103/494 (20%), Positives = 197/494 (39%), Gaps = 82/494 (16%)
Query: 30 VVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATM 89
V+ ML P + + A A + + E K + +L + L LL H VRR A
Sbjct: 363 VLAMLRHPVDPVKANAAAYLQHLCFENEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACG 422
Query: 90 IFGILASNNDV--KKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIF 147
L+ D K +R+ + +++ L + + E + L N+S+ K+ I
Sbjct: 423 ALRNLSYGRDTDNKAAIRDCGGVPALVRLLRAARDNEVRELVTGTLWNLSSYEPLKMVII 482
Query: 148 EHGGLEPLIRLL--------SSPDPDVK----------KNSMECIYNLVQD-FQCRAKLQ 188
+H GL+ L + P+ D K KN+ C+ N+ D + R +L+
Sbjct: 483 DH-GLQTLTHEVIVPHSGWEREPNEDSKPRDAEWTTVFKNTSGCLRNVSSDGAEARRRLR 541
Query: 189 ELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKILETKELND 248
E + L L L K++ DN+ +++ + I+
Sbjct: 542 ECEGLVDAL--------------LHALQSAVGRKDT-----DNKSVENCVCIMRNL---S 579
Query: 249 LHIEALAVIANCLED-----MDTMVQIQQT--------GGLK-KLLSFAENSTIPDIQKN 294
H+ A+ ++ + + V Q+ GG K K F + ++ +N
Sbjct: 580 YHVHKEVPGADRYQEAEPGPLGSAVGSQRRRRDDASCFGGKKAKEEWFHQGKKDGEMDRN 639
Query: 295 -AAKAITKAAYDPENRKLFHEQEVEKCLVALL-GSENDGTKIAASQAISAMCENSGSKDF 352
+ K + +L ++ EV + ++LL S N T AA+ A+ + +
Sbjct: 640 FDTLDLPKRTEAAKGFELLYQPEVVRLYLSLLTESRNFNTLEAAAGALQNLSAGNWMWAT 699
Query: 353 F------NNQGIPQLIQLLKSDNEEVREAAALALANLT--TCNPANANAAAEADGIDPLI 404
+ +G+P L++LL+S+ ++V A A+AL NL+ N + A A+ + +
Sbjct: 700 YIRATVRKERGLPVLVELLQSETDKVVRAVAIALRNLSLDRRNKDLIGSYAMAELVRNVR 759
Query: 405 NLLSSKRDGAIANAATVLTNMAMQEPLRLNIQNHDIMHAIIS-PLRSANTVVQSKAALAV 463
N + R GA TV+ + + +H I+S L +A +++Q++ A+
Sbjct: 760 NAQAPPRPGACLEEDTVVAVL-------------NTIHEIVSDSLDNARSLLQARGVPAL 806
Query: 464 TATACDVEARTELR 477
A ++ E +
Sbjct: 807 VALVASSQSVREAK 820
Score = 31.6 bits (70), Expect = 3.3
Identities = 33/128 (25%), Positives = 61/128 (47%), Gaps = 8/128 (6%)
Query: 379 ALANLTTCNPANANAAAEADGIDP----LINLLSSKRDGAIANAATVLTNMAMQ-EPLRL 433
+L L +P+ +A E DP ++ +L D ANAA L ++ + E ++
Sbjct: 335 SLDRLVRRSPSVDSARKEPRWRDPELPEVLAMLRHPVDPVKANAAAYLQHLCFENEGVKR 394
Query: 434 NIQNHDIMHAIISPLRSANTVVQSKA--ALAVTATACDVEARTELRNSGGLEPLVELLRS 491
++ + +++ L V+ +A AL + D + + +R+ GG+ LV LLR+
Sbjct: 395 RVRQLRGLPLLVALLDHPRAEVRRRACGALRNLSYGRDTDNKAAIRDCGGVPALVRLLRA 454
Query: 492 KND-EVRK 498
D EVR+
Sbjct: 455 ARDNEVRE 462
>gi|207029299 NIMA-related kinase 10 isoform 3 [Homo sapiens]
Length = 712
Score = 53.5 bits (127), Expect = 8e-07
Identities = 34/131 (25%), Positives = 69/131 (52%), Gaps = 1/131 (0%)
Query: 150 GGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQL 209
G + L+ LL + D +V S+ + +L + +CR K+ ELN + +L +L + +
Sbjct: 209 GAHKTLVNLLGARDTNVLLGSLLALASLAESQECREKISELNIVENLLMILHEYDLLSKR 268
Query: 210 LALKTLGVIANDKESRTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQ 269
L + L ++ + + + ++ +G+ L+ +L + L L ++ C ED +T V+
Sbjct: 269 LTAELLRLLCAEPQVKEQVKLYEGIPVLLSLLHSDHLKLLWSIVWILVQVC-EDPETSVE 327
Query: 270 IQQTGGLKKLL 280
I+ GG+K+LL
Sbjct: 328 IRIWGGIKQLL 338
Score = 35.8 bits (81), Expect = 0.18
Identities = 37/180 (20%), Positives = 80/180 (44%), Gaps = 7/180 (3%)
Query: 361 LIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAAT 420
L+ LL + + V + LALA+L + E + ++ L+ +L + A
Sbjct: 214 LVNLLGARDTNVLLGSLLALASLAESQECREKIS-ELNIVENLLMILHEYDLLSKRLTAE 272
Query: 421 VLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACDVEARTELRNSG 480
+L + + ++ ++ ++ + ++S L S + + + D E E+R G
Sbjct: 273 LLRLLCAEPQVKEQVKLYEGIPVLLSLLHSDHLKLLWSIVWILVQVCEDPETSVEIRIWG 332
Query: 481 GLEPLVELLRSKNDEVRKHASWAVMVCAGDELTANELCRLGALDILEEVNVSGTRKNKFS 540
G++ L+ +L+ + V H+S G +AN R+ L + E+++ ++N FS
Sbjct: 333 GIKQLLHILQGDRNFVSDHSS------IGSLSSANAAGRIQQLHLSEDLSPREIQENTFS 386
>gi|224589129 karyopherin 7 [Homo sapiens]
Length = 516
Score = 52.8 bits (125), Expect = 1e-06
Identities = 100/459 (21%), Positives = 182/459 (39%), Gaps = 58/459 (12%)
Query: 51 KFALKGEENKTTLLELGAVE-PLTKLLTHEDKIVRRNATMIFGILASNNDVKKLLRELDV 109
KF +G++ + AV L K E + RRN T S K + L
Sbjct: 13 KFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSEKTAKGVAVSL-T 71
Query: 110 MNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIR--LLSSPDPDVK 167
+ +I + + V+ + +S E +++ GL P + L SS P ++
Sbjct: 72 LGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQ 131
Query: 168 KNSMECIYNLVQDF--QCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIAND-KES 224
+ + N+ Q RA + E AI P+++LL S + A+ LG IA D E
Sbjct: 132 FEAAWALTNIASGTSEQTRAVV-EGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEF 190
Query: 225 RTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAE 284
R + + + HL LA+I+ L ++F
Sbjct: 191 RDNVITSNAIPHL----------------LALISPTLP-----------------ITFLR 217
Query: 285 NST--IPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISA 342
N T + ++ +N K Y + +++ L+ LL ++ A A+S
Sbjct: 218 NITWTLSNLCRN------KNPYPCDTAV----KQILPALLHLLQHQDSEVLSDACWALSY 267
Query: 343 MCENSGSK--DFFNNQGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGI 400
+ + S + N +P+L+ L+ S V + + N+ T A +A +
Sbjct: 268 LTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGML 327
Query: 401 DPLINLLSSKRDGAIANAATVLTNMAMQEPLRLN-IQNHDIMHAIISPLRSANTVVQSKA 459
+ L LL + AA L+N+A + + +D++ +++ L++ VQ +A
Sbjct: 328 NVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEA 387
Query: 460 ALAVT--ATACDVEARTELRNSGGLEPLVELLRSKNDEV 496
V AT ++ +L +SG LEPLV LL + + ++
Sbjct: 388 VWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKI 426
Score = 45.8 bits (107), Expect = 2e-04
Identities = 37/165 (22%), Positives = 79/165 (47%), Gaps = 6/165 (3%)
Query: 30 VVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATM 89
+V+++ S E +L + + +E ++ G + L +LL H +++ A
Sbjct: 288 LVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAW 347
Query: 90 IFGILASN--NDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSK--VQ 145
+A+ + +++LL DV+ ++A L E + + A +AN + T +Q
Sbjct: 348 ALSNVAAGPCHHIQQLLA-YDVLPPLVA-LLKNGEFKVQKEAVWMVANFATGATMDQLIQ 405
Query: 146 IFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAKLQEL 190
+ G LEPL+ LL++PD + ++ I ++Q + R++ + L
Sbjct: 406 LVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAAEKRSEKENL 450
Score = 44.7 bits (104), Expect = 4e-04
Identities = 49/234 (20%), Positives = 103/234 (44%), Gaps = 9/234 (3%)
Query: 33 MLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATMIFG 92
+L + E+L+ AC A+ + ++ G + L L+T + V + G
Sbjct: 249 LLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVG 308
Query: 93 ILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKV-QIFEHGG 151
+ + D + + M +V+ QL + I + A+ L+N++A + Q+ +
Sbjct: 309 NIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDV 368
Query: 152 LEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAKLQELNA--IPPILDLLKSEYPVIQL 209
L PL+ LL + + V+K ++ + N +Q +++ + P+++LL + I L
Sbjct: 369 LPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKIVL 428
Query: 210 LALKTLGVI------ANDKESRTMLRDNQGLDHLIKILETKELNDLHIEALAVI 257
+ L + I ++KE+ +L + G I+ L+ E + AL +I
Sbjct: 429 IILDVISCILQAAEKRSEKENLCLLIEELGGIDRIEALQLHENRQIGQSALNII 482
Score = 43.9 bits (102), Expect = 7e-04
Identities = 57/192 (29%), Positives = 77/192 (40%), Gaps = 25/192 (13%)
Query: 358 IPQLIQLLKSDNEEVRE-AAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIA 416
IP++++ LKS + AA AL N+ + A E I PLI LLSS
Sbjct: 115 IPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCE 174
Query: 417 NAATVLTNMAMQEP-LRLN-IQNHDIMH--AIISP------LRSANTVVQSKAALAVTAT 466
A L N+A P R N I ++ I H A+ISP LR+ T S
Sbjct: 175 QAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNI-TWTLSNLCRNKNPY 233
Query: 467 ACDVEARTELRNSGGLEPLVELLRSKNDEVRKHASWAVMVCA-------GDELTANELCR 519
CD + L L+ LL+ ++ EV A WA+ G + L R
Sbjct: 234 PCDTAVKQI------LPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPR 287
Query: 520 LGALDILEEVNV 531
L L E+NV
Sbjct: 288 LVVLMTSSELNV 299
Score = 41.2 bits (95), Expect = 0.004
Identities = 84/411 (20%), Positives = 148/411 (36%), Gaps = 89/411 (21%)
Query: 3 KKIKKEVEPPPKDVFDPLMIESKKAATVVLMLNSPEEEILA-KACEAIYKFALKGEENKT 61
K + +E PP K L+IE+ +V L S L +A A+ A E
Sbjct: 96 KMLSQEKNPPLK-----LVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTR 150
Query: 62 TLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNN-DVKKLLRELDVMNSVIAQLAPE 120
++E GA++PL +LL+ + V A G +A + + + + + + ++A ++P
Sbjct: 151 AVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPT 210
Query: 121 EEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQD 180
+ + L+N+ KN C + Q
Sbjct: 211 LPITFLRNITWTLSNLCR----------------------------NKNPYPCDTAVKQ- 241
Query: 181 FQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQG-LDHLIK 239
+P +L LL+ + + A L + + R N G L L+
Sbjct: 242 -----------ILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVV 290
Query: 240 ILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAI 299
++ + ELN L +L + N + D Q+ G+ +L P IQK AA A+
Sbjct: 291 LMTSSELNVL-TPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWAL 349
Query: 300 TKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIP 359
+ A P H Q++ V +P
Sbjct: 350 SNVAAGP----CHHIQQLLAYDV-----------------------------------LP 370
Query: 360 QLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGI-DPLINLLSS 409
L+ LLK+ +V++ A +AN T + G+ +PL+NLL++
Sbjct: 371 PLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTA 421
Score = 40.4 bits (93), Expect = 0.007
Identities = 75/342 (21%), Positives = 141/342 (41%), Gaps = 13/342 (3%)
Query: 196 ILDLLKSEYPVIQLLALKTLG-VIANDKESRTMLRDNQGL-DHLIKILETKELNDLHIEA 253
I+ + S PV+ A +T +++ +K L GL +++ L++ L EA
Sbjct: 75 IIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEA 134
Query: 254 LAVIANCLEDMDTMVQ-IQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYD-PENRKL 311
+ N + + + G ++ L+ +S + + + A A+ A D PE R
Sbjct: 135 AWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVA-VCEQAVWALGNIAGDGPEFRDN 193
Query: 312 FHEQEVEKCLVALLGSENDGTKIA-ASQAISAMCENSGSK--DFFNNQGIPQLIQLLKSD 368
L+AL+ T + + +S +C N D Q +P L+ LL+
Sbjct: 194 VITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQ 253
Query: 369 NEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNMAM- 427
+ EV A AL+ LT + + L+ L++S + + + N+
Sbjct: 254 DSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTG 313
Query: 428 -QEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACD-VEARTELRNSGGLEPL 485
E ++ I + +++ + L+ +Q +AA A++ A +L L PL
Sbjct: 314 TDEQTQMAI-DAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPL 372
Query: 486 VELLRSKNDEVRKHASWAVMVCAGDELTANELCRLGALDILE 527
V LL++ +V+K A W V A T ++L +L +LE
Sbjct: 373 VALLKNGEFKVQKEAVWMVANFA-TGATMDQLIQLVHSGVLE 413
>gi|222144293 karyopherin alpha 1 [Homo sapiens]
Length = 538
Score = 51.2 bits (121), Expect = 4e-06
Identities = 66/311 (21%), Positives = 128/311 (41%), Gaps = 15/311 (4%)
Query: 189 ELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKE-SRTMLRDNQGLDHLIKILETKELN 247
+ A+P ++LL SE+ +Q A+ LG IA D R + D L L+++ +
Sbjct: 167 QAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRL 226
Query: 248 DLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPE 307
+ A+ ++N + + +LS+ + D+ +A A++ + P
Sbjct: 227 TMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPN 286
Query: 308 NR-KLFHEQEVEKCLVALLGSENDGTKIAASQAISAMC--ENSGSKDFFNNQGIPQLIQL 364
++ + + V + LV LL + A +A+ + ++ ++ N + L+ L
Sbjct: 287 DKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHL 346
Query: 365 LKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTN 424
L S E +++ A ++N+T N A +A+ LI++L + AA +TN
Sbjct: 347 LSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITN 406
Query: 425 M---AMQEPLRLNIQNHDIMHAIISPLRSANTVVQSK---AALAVTATACDVEARTELRN 478
E ++ ++ I PL TV+ SK AL + + RN
Sbjct: 407 ATSGGSAEQIKYLVE-----LGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRN 461
Query: 479 SGGLEPLVELL 489
G+ P L+
Sbjct: 462 GTGINPYCALI 472
Score = 45.1 bits (105), Expect = 3e-04
Identities = 56/252 (22%), Positives = 113/252 (44%), Gaps = 20/252 (7%)
Query: 38 EEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASN 97
+ ++LA AC A+ + + +++ G L +LL H D V A G + +
Sbjct: 267 DTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTG 326
Query: 98 NDVK-KLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEP-L 155
+D++ +++ + S++ L+ +E + E A ++N++A +++Q + P L
Sbjct: 327 DDIQTQVILNCSALQSLLHLLSSPKESIKKE-ACWTISNITAGNRAQIQTVIDANIFPAL 385
Query: 156 IRLLSSPDPDVKKNSMECIYNLVQDFQCR--AKLQELNAIPPILDLLKSEYPVIQLLALK 213
I +L + + +K + I N L EL I P+ DLL I +AL
Sbjct: 386 ISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALN 445
Query: 214 TLGVI--ANDKESR----------TMLRDNQGLDHLIKILETKELNDLHIEALAVIANCL 261
L I ++E++ ++ + GLD I+ L++ E +++ +A +I +
Sbjct: 446 GLENILRLGEQEAKRNGTGINPYCALIEEAYGLDK-IEFLQSHENQEIYQKAFDLIEHYF 504
Query: 262 --EDMDTMVQIQ 271
ED D+ + Q
Sbjct: 505 GTEDEDSSIAPQ 516
Score = 34.7 bits (78), Expect = 0.40
Identities = 24/77 (31%), Positives = 40/77 (51%), Gaps = 5/77 (6%)
Query: 449 RSANTVVQSKAALAVTATACDVEARTELRNSGGLEPL-VELLRSKNDEVRKHASWAVMVC 507
R N +Q ++A +T A +T + G P+ +ELL S+ ++V++ A WA+
Sbjct: 137 RKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNI 196
Query: 508 AGDELTANELCRLGALD 524
AGD + +CR LD
Sbjct: 197 AGD----STMCRDYVLD 209
Score = 34.3 bits (77), Expect = 0.52
Identities = 42/173 (24%), Positives = 79/173 (45%), Gaps = 4/173 (2%)
Query: 358 IPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSK-RDGAIA 416
+P I+LL S+ E+V+E A AL N+ + + + + + PL+ L S + R
Sbjct: 171 VPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTR 230
Query: 417 NAATVLTNMAM-QEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACDVEARTE 475
NA L+N+ + P + ++ + L ++T V + A A++ + + +
Sbjct: 231 NAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQ 290
Query: 476 -LRNSGGLEPLVELLRSKNDEVRKHASWAV-MVCAGDELTANELCRLGALDIL 526
+ ++G LVELL + +V A AV + GD++ + AL L
Sbjct: 291 AVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSL 343
>gi|11034811 catenin (cadherin-associated protein), delta 2 (neural
plakophilin-related arm-repeat protein) [Homo sapiens]
Length = 1225
Score = 50.8 bits (120), Expect = 5e-06
Identities = 45/152 (29%), Positives = 69/152 (45%), Gaps = 15/152 (9%)
Query: 359 PQLIQLLKSDNEEVREAAALALANLTTCN---PANANAAAEAD-GIDPLINLLSSKRDGA 414
P L L + N + E AA AL NL + AA + G+ L+ LL D
Sbjct: 849 PYLTLLSECSNPDTLEGAAGALQNLAAGSWKWSVYIRAAVRKEKGLPILVELLRIDNDRV 908
Query: 415 IANAATVLTNMAMQEPLRLNIQNH---DIMHAIISPLRSANTVVQSKAALAVTATAC--- 468
+ AT L NMA+ + I + D++H + S NT ++ + VTA C
Sbjct: 909 VCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGNNSNNTASKAMSDDTVTAVCCTLH 968
Query: 469 -----DVEARTELRNSGGLEPLVELLRSKNDE 495
++E LR++GG+E LV + +SK D+
Sbjct: 969 EVITKNMENAKALRDAGGIEKLVGISKSKGDK 1000
>gi|34485722 karyopherin alpha 3 [Homo sapiens]
Length = 521
Score = 49.7 bits (117), Expect = 1e-05
Identities = 63/258 (24%), Positives = 118/258 (45%), Gaps = 18/258 (6%)
Query: 10 EPPPKDVFDPLMIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAV 69
+PPP P+ + + +++ + IL A+ G E +++ G V
Sbjct: 232 DPPP-----PMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVV 286
Query: 70 EPLTKLLTHEDKIVRRNATMIFG-ILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEF 128
L LL+H++ V+ A G I+ ++ +++ DV++ L+ +E + E
Sbjct: 287 PFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKE- 345
Query: 129 ASLCLANMSAEYTSKVQIFEHGGLEP-LIRLLSSPDPDVKKNSMECIYNLV---QDFQCR 184
A L+N++A +VQ GL P +I L+ D +K + I NL + Q
Sbjct: 346 AVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVE 405
Query: 185 AKLQELNAIPPILDLLK---SEYPVIQLLALKTLGVIANDKES--RTMLRDNQGLDHLIK 239
+Q+ N IPP +LL S+ + L LK + ++A D+ S ++ + GL+ I+
Sbjct: 406 YLVQQ-NVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEK-IE 463
Query: 240 ILETKELNDLHIEALAVI 257
+L+ E D++ A +I
Sbjct: 464 VLQQHENEDIYKLAFEII 481
Score = 43.9 bits (102), Expect = 7e-04
Identities = 85/405 (20%), Positives = 163/405 (40%), Gaps = 43/405 (10%)
Query: 152 LEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLKS--------- 202
LE +++ +S +P V+ +++ Q KL + PPI DL+KS
Sbjct: 73 LEAILQNATSDNPVVQLSAV----------QAARKLLSSDRNPPIDDLIKSGILPILVKC 122
Query: 203 ----EYPVIQLLALKTLGVIANDKESRTM-LRDNQGLDHLIKILETKELNDLHIEALAVI 257
+ P +Q A L IA+ ++T + + + +++L + N +A+ +
Sbjct: 123 LERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCE-QAVWAL 181
Query: 258 ANCLED----MDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPENRKLFH 313
N + D D ++ + G +K LLSF S +N I + +
Sbjct: 182 GNIIGDGPQCRDYVISL---GVVKPLLSFISPSIPITFLRNVTWVIVNLCRNKDPPPPME 238
Query: 314 E-QEVEKCLVALLGSENDGTKIAASQAISAMCE--NSGSKDFFNNQGIPQLIQLLKSDNE 370
QE+ L L+ + + A+S + + N + ++ +P L+ LL
Sbjct: 239 TVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEV 298
Query: 371 EVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNMAMQEP 430
+V+ AA A+ N+ T D + NLLS ++ A L+N+
Sbjct: 299 KVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQ 358
Query: 431 LRLN-IQNHDIMHAIISPLRSANTVVQSKAALAVT-ATACDVEARTE-LRNSGGLEPLVE 487
++ + + ++ II L + Q +AA A++ T + + E L + P
Sbjct: 359 QQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCN 418
Query: 488 LLRSKNDEVRK---HASWAVMVCAGDELT--ANELCRLGALDILE 527
LL K+ +V + +++ AGDE + A + G L+ +E
Sbjct: 419 LLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIE 463
Score = 37.7 bits (86), Expect = 0.047
Identities = 32/160 (20%), Positives = 69/160 (43%), Gaps = 2/160 (1%)
Query: 21 MIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHED 80
+++S + +L SP + + +A A+ G + + ++ LG V+PL ++
Sbjct: 153 VVQSNAVPLFLRLLRSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSI 212
Query: 81 KIV-RRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAE 139
I RN T + L N D + + + + L ++ I L+ ++
Sbjct: 213 PITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDG 272
Query: 140 YTSKVQIFEHGGLEP-LIRLLSSPDPDVKKNSMECIYNLV 178
++Q+ G+ P L+ LLS + V+ ++ + N+V
Sbjct: 273 GNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIV 312
>gi|7657530 rhabdoid tumor deletion region protein 1 [Homo sapiens]
Length = 348
Score = 48.1 bits (113), Expect = 3e-05
Identities = 70/303 (23%), Positives = 118/303 (38%), Gaps = 24/303 (7%)
Query: 147 FEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPV 206
+ H L L L S D ++ ++ + +L+ D +C K + + + LLK +
Sbjct: 23 YGHRALPKLKEELQSEDLQTRQKALMALCDLMHDPECIYKAMNIGCMENLKALLKDSNSM 82
Query: 207 IQLLALKTLGVIANDKESRTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDT 266
+++ + L + A+ R L+H I + + LND + N +
Sbjct: 83 VRIKTTEVLHITASHSVGRYAF-----LEHDIVLALSFLLND---PSPVCRGNLYKAYMQ 134
Query: 267 MVQIQQTGGLKKLLSFAENSTI----------PDIQKNAAKAITKAAYDPENRKLFHEQE 316
+VQ+ + G ++++S S++ + Q+ + + L
Sbjct: 135 LVQVPR--GAQEIISKGLISSLVWKLQVEVEEEEFQEFILDTLVLCLQEDATEAL--GSN 190
Query: 317 VEKCLVALLGSENDGTKIAASQAI-SAMCENSGSKDFFNNQGIPQLIQLLKSDNEEVREA 375
V L L S N + A++A+ + G K + IP L+ LLK E V+
Sbjct: 191 VVLVLKQKLLSANQNIRSKAARALLNVSISREGKKQVCHFDVIPILVHLLKDPVEHVKSN 250
Query: 376 AALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNMAMQEPLRLNI 435
AA AL T AA EA I L+ LL S A NA LT +A R +
Sbjct: 251 AAGALMFATVITEGK-YAALEAQAIGLLLELLHSPMTIARLNATKALTMLAEAPEGRKAL 309
Query: 436 QNH 438
Q H
Sbjct: 310 QTH 312
Score = 37.4 bits (85), Expect = 0.061
Identities = 29/105 (27%), Positives = 45/105 (42%)
Query: 125 IHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCR 184
I A+ L N+S K Q+ + L+ LL P VK N+ + + +
Sbjct: 206 IRSKAARALLNVSISREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGALMFATVITEGK 265
Query: 185 AKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLR 229
E AI +L+LL S + +L A K L ++A E R L+
Sbjct: 266 YAALEAQAIGLLLELLHSPMTIARLNATKALTMLAEAPEGRKALQ 310
>gi|4504901 karyopherin alpha 4 [Homo sapiens]
Length = 521
Score = 48.1 bits (113), Expect = 3e-05
Identities = 76/384 (19%), Positives = 141/384 (36%), Gaps = 53/384 (13%)
Query: 129 ASLCLANMSAEYTSKVQIFEHGGLEPL-IRLLSSPDPDVKKNSMECIYNLVQDF-QCRAK 186
A+ L N+++ + + Q PL +RLL SP +V + ++ + N++ D QCR
Sbjct: 135 AAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDY 194
Query: 187 LQELNAIPPILDLLKSEYPVIQLLALKTLGV-IANDKESRTMLRDNQGLDHLIKILETKE 245
+ L + P+L + P+ L + + V + K+ + Q
Sbjct: 195 VISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQ------------- 241
Query: 246 LNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYD 305
E L + + D + + L S + D + + +
Sbjct: 242 ------EILPALCVLIHHTDVNILVDTVWAL---------SYLTDAGNEQIQMVIDSGIV 286
Query: 306 PENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIPQLIQLL 365
P L QEV+ AL N T + C+ + LL
Sbjct: 287 PHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCD-----------ALSHFPALL 335
Query: 366 KSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNM 425
E++ + A L+N+T N A +A+ + +I+LL G AA ++N+
Sbjct: 336 THPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNL 395
Query: 426 AMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACDV------EART---EL 476
+ R + + I +I P + TV ++ V ++ EA T +
Sbjct: 396 TISG--RKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLI 453
Query: 477 RNSGGLEPLVELLRSKNDEVRKHA 500
GGLE + +L +N+++ K A
Sbjct: 454 EECGGLEKIEQLQNHENEDIYKLA 477
Score = 45.4 bits (106), Expect = 2e-04
Identities = 60/256 (23%), Positives = 113/256 (44%), Gaps = 17/256 (6%)
Query: 11 PPPKDVFDPLMIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVE 70
PPP + ++ + ++++ + IL A+ G E +++ G V
Sbjct: 234 PPPMETIQEIL------PALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVP 287
Query: 71 PLTKLLTHEDKIVRRNATMIFG-ILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFA 129
L LL+H++ V+ A G I+ ++ +++ D ++ A L +E + E A
Sbjct: 288 HLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKE-A 346
Query: 130 SLCLANMSAEYTSKVQIFEHGGLEP-LIRLLSSPDPDVKKNSMECIYNLVQDFQCR--AK 186
L+N++A +VQ L P +I LL D +K + I NL + A
Sbjct: 347 VWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAY 406
Query: 187 LQELNAIPPILDLLK-SEYPVIQLL--ALKTLGVIANDKESR--TMLRDNQGLDHLIKIL 241
L + N IPP +LL + V+Q++ L + +A D+ ++ + GL+ I+ L
Sbjct: 407 LIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEK-IEQL 465
Query: 242 ETKELNDLHIEALAVI 257
+ E D++ A +I
Sbjct: 466 QNHENEDIYKLAYEII 481
Score = 38.1 bits (87), Expect = 0.036
Identities = 32/160 (20%), Positives = 70/160 (43%), Gaps = 2/160 (1%)
Query: 21 MIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHED 80
+++S + +L+SP + + +A A+ G + + ++ LG V+PL ++
Sbjct: 153 VVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSI 212
Query: 81 KIV-RRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAE 139
I RN T + L + D + + + + L +V I L+ ++
Sbjct: 213 PITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDA 272
Query: 140 YTSKVQIFEHGGLEP-LIRLLSSPDPDVKKNSMECIYNLV 178
++Q+ G+ P L+ LLS + V+ ++ + N+V
Sbjct: 273 GNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIV 312
>gi|4504897 karyopherin alpha 2 [Homo sapiens]
Length = 529
Score = 47.4 bits (111), Expect = 6e-05
Identities = 35/142 (24%), Positives = 68/142 (47%), Gaps = 3/142 (2%)
Query: 358 IPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIAN 417
+PQL++LL + + A A+ N+ T +A + +LL++ +
Sbjct: 295 VPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKE 354
Query: 418 AATVLTNM-AMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVT--ATACDVEART 474
A ++N+ A ++ + NH ++ ++S L A+ Q +A AVT + VE
Sbjct: 355 ATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIV 414
Query: 475 ELRNSGGLEPLVELLRSKNDEV 496
L + G +EPL+ LL +K+ ++
Sbjct: 415 YLVHCGIIEPLMNLLTAKDTKI 436
Score = 46.6 bits (109), Expect = 1e-04
Identities = 60/257 (23%), Positives = 115/257 (44%), Gaps = 19/257 (7%)
Query: 12 PPKDVFDPLMIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEP 71
PP D + ++ T+V +L+ + E+LA C AI E +++ G V
Sbjct: 244 PPIDAVEQIL------PTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQ 297
Query: 72 LTKLL-THEDKIVRRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFAS 130
L KLL E IV I I+ ++ +++ + + +V L + I + A+
Sbjct: 298 LVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGAL-AVFPSLLTNPKTNIQKEAT 356
Query: 131 LCLANMSAEYTSKV-QIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQ--DFQCRAKL 187
++N++A ++ Q+ HG + L+ +LS D +K ++ + N + L
Sbjct: 357 WTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYL 416
Query: 188 QELNAIPPILDLLKSEYPVIQLLALKTLGVI--ANDKESRT-----MLRDNQGLDHLIKI 240
I P+++LL ++ I L+ L + I A +K T M+ + GLD I+
Sbjct: 417 VHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDK-IEA 475
Query: 241 LETKELNDLHIEALAVI 257
L+ E ++ +L++I
Sbjct: 476 LQNHENESVYKASLSLI 492
Score = 35.0 bits (79), Expect = 0.30
Identities = 59/272 (21%), Positives = 101/272 (37%), Gaps = 39/272 (14%)
Query: 31 VLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATMI 90
+ +L SP I +A A+ A G + +++ GAV+PL LL D +++
Sbjct: 168 ISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDM-----SSLA 222
Query: 91 FGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHG 150
G L + + ++LC A V+
Sbjct: 223 CGYLRN---------------------------LTWTLSNLCRNKNPAPPIDAVEQI--- 252
Query: 151 GLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCR-AKLQELNAIPPILDLL-KSEYPVIQ 208
L L+RLL DP+V ++ I L R + + +P ++ LL SE P++
Sbjct: 253 -LPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIV- 310
Query: 209 LLALKTLGVIANDKESRTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMV 268
AL+ +G I + +T + + G + L T ++ EA ++N +
Sbjct: 311 TPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQI 370
Query: 269 QIQQTGGLKKLLSFAENSTIPDIQKNAAKAIT 300
Q GL L + QK A A+T
Sbjct: 371 QQVVNHGLVPFLVSVLSKADFKTQKEAVWAVT 402
Score = 33.1 bits (74), Expect = 1.2
Identities = 37/132 (28%), Positives = 60/132 (45%), Gaps = 4/132 (3%)
Query: 398 DGIDPLINLLSSKRDGAIANAATVLTNMAMQEPLRLNIQNHDIMHAIISPL-RSANTVVQ 456
D I IN + + AA L + Q P+ NI ++ +S L R+ + +Q
Sbjct: 79 DDIVKGINSSNVENQLQATQAARKLLSREKQPPID-NIIRAGLIPKFVSFLGRTDCSPIQ 137
Query: 457 SKAALAVTATACDVEARTELRNSGGLEP-LVELLRSKNDEVRKHASWAVMVCAGDELTAN 515
++A A+T A +T+ GG P + LL S + + + A WA+ AGD
Sbjct: 138 FESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFR 197
Query: 516 EL-CRLGALDIL 526
+L + GA+D L
Sbjct: 198 DLVIKYGAVDPL 209
>gi|53829376 plakophilin 4 isoform b [Homo sapiens]
Length = 1149
Score = 46.2 bits (108), Expect = 1e-04
Identities = 42/152 (27%), Positives = 72/152 (47%), Gaps = 22/152 (14%)
Query: 359 PQLIQLLKSDNEEVREAAALALANLTTCN---PANANAAAEAD-GIDPLINLLSSKRDGA 414
P L L +S N E +A +L NL+ N A AA + G+ L+ LL D
Sbjct: 829 PYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRV 888
Query: 415 IANAATVLTNMAMQEPLRLNIQNHDI-----MHAIISPLRSAN--TVVQSKAALAVTA-- 465
+++ AT L NMA L+++N ++ M +++ L N +V+ + A+
Sbjct: 889 VSSVATALRNMA------LDVRNKELIGKYAMRDLVNRLPGGNGPSVLSDETMAAICCAL 942
Query: 466 ---TACDVEARTELRNSGGLEPLVELLRSKND 494
T+ ++E L +SGG+E LV + + + D
Sbjct: 943 HEVTSKNMENAKALADSGGIEKLVNITKGRGD 974
Score = 43.1 bits (100), Expect = 0.001
Identities = 33/122 (27%), Positives = 54/122 (44%), Gaps = 10/122 (8%)
Query: 321 LVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIPQLIQLLKSDN------EEVRE 374
LV LL +ND + + A+ M + +K+ + L+ L N +E
Sbjct: 877 LVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGGNGPSVLSDETMA 936
Query: 375 AAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGA----IANAATVLTNMAMQEP 430
A AL +T+ N NA A A++ GI+ L+N+ + D + + AA VL +
Sbjct: 937 AICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVLNTLWQYRD 996
Query: 431 LR 432
LR
Sbjct: 997 LR 998
Score = 36.6 bits (83), Expect = 0.10
Identities = 34/139 (24%), Positives = 54/139 (38%), Gaps = 39/139 (28%)
Query: 260 CLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPENRKLFHEQEVEK 319
C D +++ + GG+K L+ ++ + ++QKNA A+ +
Sbjct: 556 CFGDNKVKMEVCRLGGIKHLVDLLDHRVL-EVQKNACGALRNLVF--------------- 599
Query: 320 CLVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIPQLIQLL-KSDNEEVREAAAL 378
G D KIA N GIP L++LL KS + EVRE
Sbjct: 600 ------GKSTDENKIAMK----------------NVGGIPALLRLLRKSIDAEVRELVTG 637
Query: 379 ALANLTTCNPANANAAAEA 397
L NL++C+ +A
Sbjct: 638 VLWNLSSCDAVKMTIIRDA 656
>gi|53829374 plakophilin 4 isoform a [Homo sapiens]
Length = 1192
Score = 46.2 bits (108), Expect = 1e-04
Identities = 42/152 (27%), Positives = 72/152 (47%), Gaps = 22/152 (14%)
Query: 359 PQLIQLLKSDNEEVREAAALALANLTTCN---PANANAAAEAD-GIDPLINLLSSKRDGA 414
P L L +S N E +A +L NL+ N A AA + G+ L+ LL D
Sbjct: 829 PYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRV 888
Query: 415 IANAATVLTNMAMQEPLRLNIQNHDI-----MHAIISPLRSAN--TVVQSKAALAVTA-- 465
+++ AT L NMA L+++N ++ M +++ L N +V+ + A+
Sbjct: 889 VSSVATALRNMA------LDVRNKELIGKYAMRDLVNRLPGGNGPSVLSDETMAAICCAL 942
Query: 466 ---TACDVEARTELRNSGGLEPLVELLRSKND 494
T+ ++E L +SGG+E LV + + + D
Sbjct: 943 HEVTSKNMENAKALADSGGIEKLVNITKGRGD 974
Score = 43.1 bits (100), Expect = 0.001
Identities = 33/122 (27%), Positives = 54/122 (44%), Gaps = 10/122 (8%)
Query: 321 LVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIPQLIQLLKSDN------EEVRE 374
LV LL +ND + + A+ M + +K+ + L+ L N +E
Sbjct: 877 LVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGGNGPSVLSDETMA 936
Query: 375 AAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGA----IANAATVLTNMAMQEP 430
A AL +T+ N NA A A++ GI+ L+N+ + D + + AA VL +
Sbjct: 937 AICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVLNTLWQYRD 996
Query: 431 LR 432
LR
Sbjct: 997 LR 998
Score = 36.6 bits (83), Expect = 0.10
Identities = 34/139 (24%), Positives = 54/139 (38%), Gaps = 39/139 (28%)
Query: 260 CLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPENRKLFHEQEVEK 319
C D +++ + GG+K L+ ++ + ++QKNA A+ +
Sbjct: 556 CFGDNKVKMEVCRLGGIKHLVDLLDHRVL-EVQKNACGALRNLVF--------------- 599
Query: 320 CLVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIPQLIQLL-KSDNEEVREAAAL 378
G D KIA N GIP L++LL KS + EVRE
Sbjct: 600 ------GKSTDENKIAMK----------------NVGGIPALLRLLRKSIDAEVRELVTG 637
Query: 379 ALANLTTCNPANANAAAEA 397
L NL++C+ +A
Sbjct: 638 VLWNLSSCDAVKMTIIRDA 656
>gi|6005830 plakophilin 3 [Homo sapiens]
Length = 797
Score = 44.7 bits (104), Expect = 4e-04
Identities = 31/112 (27%), Positives = 53/112 (47%), Gaps = 5/112 (4%)
Query: 356 QGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAI 415
Q +P+L++L N+EV+ A A+ NL N N A E +GI L+ L + D
Sbjct: 361 QAVPRLVKLFNHANQEVQRHATGAMRNLIYDNADNKLALVEENGIFELLRTLREQDDELR 420
Query: 416 ANAATVLTNMAMQEPLRLNIQN---HDIMHAIISPLRSAN--TVVQSKAALA 462
N +L N++ + L+ + + ++SPL A ++Q A+ A
Sbjct: 421 KNVTGILWNLSSSDHLKDRLARDTLEQLTDLVLSPLSGAGGPPLIQQNASEA 472
Score = 35.0 bits (79), Expect = 0.30
Identities = 83/407 (20%), Positives = 157/407 (38%), Gaps = 40/407 (9%)
Query: 30 VVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATM 89
+V + N +E+ A A+ +NK L+E + L + L +D +R+N T
Sbjct: 366 LVKLFNHANQEVQRHATGAMRNLIYDNADNKLALVEENGIFELLRTLREQDDELRKNVTG 425
Query: 90 IFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEH 149
I L+S++ +K L + QL ++V+ + + + S+ +IF +
Sbjct: 426 ILWNLSSSDHLKDRL-----ARDTLEQLT---DLVLSPLSGAGGPPLIQQNASEAEIFYN 477
Query: 150 GGLEPLIRLLSSPDPDVKKNSMEC----------IYNLVQDFQCRAKLQELNAIPPILDL 199
+R LSS ++ EC I + + +C K E NA+ + +L
Sbjct: 478 A--TGFLRNLSSASQATRQKMRECHGLVDALVTSINHALDAGKCEDKSVE-NAVCVLRNL 534
Query: 200 LKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKILETKELNDLHIEA----LA 255
Y + AL+ L + R + G +++ L +L + A A
Sbjct: 535 SYRLYDEMPPSALQRL----EGRGRRDLAGAPPGEVVGCFTPQSRRLRELPLAADALTFA 590
Query: 256 VIANCLEDMDTMVQIQQTGGLKKLLSFAE-NSTIPDIQKNAAKAIT---KAAYDPENRKL 311
++ + ++ + Q G +LL E N + A + IT + +R
Sbjct: 591 EVSKDPKGLEWLWSPQIVGLYNRLLQRCELNRHTTEAAAGALQNITAGDRRWAGVLSRLA 650
Query: 312 FHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIPQLIQLL------ 365
++ + L+ + + + + + I + N+ +KD + + + LI+ L
Sbjct: 651 LEQERILNPLLDRVRTADHHQLRSLTGLIRNLSRNARNKDEMSTKVVSHLIEKLPGSVGE 710
Query: 366 KSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRD 412
KS EV L NL +P A DG+ LI + KRD
Sbjct: 711 KSPPAEVLVNIIAVLNNLVVASPIAARDLLYFDGLRKLI-FIKKKRD 756
>gi|7662162 ALEX2 protein [Homo sapiens]
Length = 632
Score = 44.7 bits (104), Expect = 4e-04
Identities = 45/214 (21%), Positives = 103/214 (48%), Gaps = 12/214 (5%)
Query: 110 MNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKN 169
+ V+A L ++ I + A L L+N + ++ I + GGL + +++ DP +K+
Sbjct: 388 LRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQETIRKLGGLPIIANMINKTDPHIKEK 447
Query: 170 SMECIYNLVQDFQCRAKLQ-ELNAIPPILDLLKSEY-PVIQLLALKTLG--VIANDKESR 225
++ + NL ++++ + +LQ +N + + D++ S +Q++ LK L I ND +
Sbjct: 448 ALMAMNNLSENYENQGRLQVYMNKV--MDDIMASNLNSAVQVVGLKFLTNMTITNDYQHL 505
Query: 226 TMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAEN 285
+ + + ++L ++ + +E L +++N E+ D + ++ T S +
Sbjct: 506 LV----NSIANFFRLL-SQGGGKIKVEILKILSNFAENPDMLKKLLSTQVPASFSSLYNS 560
Query: 286 STIPDIQKNAAKAITKAAYDPENRKLFHEQEVEK 319
+I NA + + YD ++F+ +E K
Sbjct: 561 YVESEILINAL-TLFEIIYDNLRAEVFNYREFNK 593
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,450,614
Number of Sequences: 37866
Number of extensions: 1359275
Number of successful extensions: 5527
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 97
Number of HSP's that attempted gapping in prelim test: 4957
Number of HSP's gapped (non-prelim): 520
length of query: 872
length of database: 18,247,518
effective HSP length: 111
effective length of query: 761
effective length of database: 14,044,392
effective search space: 10687782312
effective search space used: 10687782312
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.