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Search of human proteins with 18860902
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18860902 protein tyrosine phosphatase, receptor type, K
isoform b [Homo sapiens]
(1440 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 2974 0.0
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 2968 0.0
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 1853 0.0
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 1848 0.0
gi|110735404 protein tyrosine phosphatase, receptor type, U isof... 1780 0.0
gi|110735406 protein tyrosine phosphatase, receptor type, U isof... 1774 0.0
gi|110735402 protein tyrosine phosphatase, receptor type, U isof... 1773 0.0
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 1767 0.0
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 1757 0.0
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 521 e-147
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 521 e-147
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 516 e-146
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 513 e-145
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 509 e-144
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 509 e-144
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 509 e-144
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 509 e-144
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 507 e-143
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 506 e-143
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 506 e-143
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 441 e-123
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 441 e-123
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 441 e-123
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor... 426 e-119
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo... 426 e-119
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 375 e-103
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 360 4e-99
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 337 5e-92
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 337 5e-92
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 337 5e-92
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 2974 bits (7711), Expect = 0.0
Identities = 1440/1440 (100%), Positives = 1440/1440 (100%)
Query: 1 MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHV 60
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHV
Sbjct: 1 MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHV 60
Query: 61 SAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNP 120
SAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNP
Sbjct: 61 SAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNP 120
Query: 121 GTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI 180
GTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
Sbjct: 121 GTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI 180
Query: 181 AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPV 240
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPV
Sbjct: 181 AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPV 240
Query: 241 AQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQL 300
AQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQL
Sbjct: 241 AQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQL 300
Query: 301 LGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE 360
LGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE
Sbjct: 301 LGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE 360
Query: 361 IRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRC 420
IRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRC
Sbjct: 361 IRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRC 420
Query: 421 HTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEE 480
HTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEE
Sbjct: 421 HTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEE 480
Query: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV 540
TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV
Sbjct: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV 540
Query: 541 AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYE 600
AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYE
Sbjct: 541 AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYE 600
Query: 601 GVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQN 660
GVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQN
Sbjct: 601 GVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQN 660
Query: 661 AMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKE 720
AMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKE
Sbjct: 661 AMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKE 720
Query: 721 TKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKL 780
TKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKL
Sbjct: 721 TKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKL 780
Query: 781 AKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAE 840
AKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAE
Sbjct: 781 AKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAE 840
Query: 841 SSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQS 900
SSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQS
Sbjct: 841 SSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQS 900
Query: 901 ASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQ 960
ASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQ
Sbjct: 901 ASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQ 960
Query: 961 GPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPL 1020
GPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPL
Sbjct: 961 GPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPL 1020
Query: 1021 AEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIV 1080
AEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIV
Sbjct: 1021 AEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIV 1080
Query: 1081 VHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAIL 1140
VHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAIL
Sbjct: 1081 VHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAIL 1140
Query: 1141 EACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPR 1200
EACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPR
Sbjct: 1141 EACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPR 1200
Query: 1201 NHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFW 1260
NHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFW
Sbjct: 1201 NHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFW 1260
Query: 1261 RLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICN 1320
RLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICN
Sbjct: 1261 RLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICN 1320
Query: 1321 LTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNG 1380
LTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNG
Sbjct: 1321 LTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNG 1380
Query: 1381 GGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS 1440
GGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS
Sbjct: 1381 GGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS 1440
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 2968 bits (7694), Expect = 0.0
Identities = 1440/1446 (99%), Positives = 1440/1446 (99%), Gaps = 6/1446 (0%)
Query: 1 MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHV 60
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHV
Sbjct: 1 MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHV 60
Query: 61 SAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNP 120
SAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNP
Sbjct: 61 SAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNP 120
Query: 121 GTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI 180
GTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
Sbjct: 121 GTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI 180
Query: 181 AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPV 240
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPV
Sbjct: 181 AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPV 240
Query: 241 AQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQL 300
AQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQL
Sbjct: 241 AQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQL 300
Query: 301 LGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE 360
LGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE
Sbjct: 301 LGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE 360
Query: 361 IRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRC 420
IRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRC
Sbjct: 361 IRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRC 420
Query: 421 HTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEE 480
HTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEE
Sbjct: 421 HTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEE 480
Query: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV 540
TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV
Sbjct: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV 540
Query: 541 AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYE 600
AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYE
Sbjct: 541 AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYE 600
Query: 601 GVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQN 660
GVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQN
Sbjct: 601 GVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQN 660
Query: 661 AMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKE 720
AMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKE
Sbjct: 661 AMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKE 720
Query: 721 TKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKL 780
TKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKL
Sbjct: 721 TKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKL 780
Query: 781 AKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAE 840
AKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAE
Sbjct: 781 AKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAE 840
Query: 841 SSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQS 900
SSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQS
Sbjct: 841 SSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQS 900
Query: 901 ASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYI------DGYQRPS 954
ASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYI DGYQRPS
Sbjct: 901 ASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPS 960
Query: 955 HYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTC 1014
HYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTC
Sbjct: 961 HYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTC 1020
Query: 1015 VEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPP 1074
VEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPP
Sbjct: 1021 VEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPP 1080
Query: 1075 SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIF 1134
SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIF
Sbjct: 1081 SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIF 1140
Query: 1135 IHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCS 1194
IHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCS
Sbjct: 1141 IHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCS 1200
Query: 1195 IACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPN 1254
IACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPN
Sbjct: 1201 IACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPN 1260
Query: 1255 TVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINR 1314
TVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINR
Sbjct: 1261 TVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINR 1320
Query: 1315 IFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTI 1374
IFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTI
Sbjct: 1321 IFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTI 1380
Query: 1375 IHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVAL 1434
IHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVAL
Sbjct: 1381 IHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVAL 1440
Query: 1435 EYLESS 1440
EYLESS
Sbjct: 1441 EYLESS 1446
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 1853 bits (4799), Expect = 0.0
Identities = 889/1445 (61%), Positives = 1096/1445 (75%), Gaps = 35/1445 (2%)
Query: 23 LLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDS 82
LL +A G+ +GGC FD+ C Y Q DDF W V+ P MP GS+M+V++
Sbjct: 14 LLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNA 73
Query: 83 SDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVT 142
S G++A L LP +KENDTHCIDF Y + S+ PG LN+ V+VN GPL NPIWN++
Sbjct: 74 SGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNIS 133
Query: 143 GFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLG 202
G R W RAELA+STFWPN YQVIFE ++ G GY+AID+++VL +PC ++PHFLR+
Sbjct: 134 GDPTRTWNRAELAISTFWPNFYQVIFEV-ITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQ 192
Query: 203 DVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTK 262
+VEVNAGQ ATFQC A GR ++LWLQ + D P+ + K + RRF ASF + TK
Sbjct: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
Query: 263 TDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGP 322
D YRC+ ++E G G+SN+A+L+V+EPP PIAPPQL VG TYL IQLNANSI GDGP
Sbjct: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
Query: 323 IILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLIT 382
I+ +EVEY SGSW + V++ +YK+ HLDPDTEYEI VLLTRPGEGGTG PGP L T
Sbjct: 313 IVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRT 372
Query: 383 RTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADC 442
RTKCA+PMR P+ L++ E+++R+I + WE GYN+TRCH++N+T+ Y Y G E +
Sbjct: 373 RTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREE 432
Query: 443 LDMDPKA--PQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQG 500
+ D + PQH + +L PYTNVS+K+IL NPEGRKES+E I+QTDED+PG VP +S+QG
Sbjct: 433 VSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQG 492
Query: 501 TSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMH 560
++FE KIFL W+EP G+IT YEI+Y ++ SFDP + ++ VS L N TH +F
Sbjct: 493 STFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFG 552
Query: 561 LHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPA 620
L+PGTTY F IRAST KGFGP TT ISAP++P YE ++ LN+T T+TV+L+PA
Sbjct: 553 LYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYE-LETPLNQTDNTVTVMLKPA 611
Query: 621 QAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLP 680
++GAP+S YQIVVEE P RTK+ ++CY VP+ +QNA + YYFAAE P +L
Sbjct: 612 HSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQ 671
Query: 681 EPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEV 740
PFT+GDN+TY G+WN PL P K Y IYFQA S ETK CV++ATK AAT +P
Sbjct: 672 AAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKP-- 729
Query: 741 IPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVN 800
+P+P KQTD VKIAG+ AGIL+F+++ L V+L++KK KLAKKRK+ M +TRQEMT MVN
Sbjct: 730 VPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVN 789
Query: 801 AMDRSYADQSTLHAEDPLSITFMDQHNFSPRY-------------------------ENH 835
+MD+SYA+Q T E + +FMD HN + R E H
Sbjct: 790 SMDKSYAEQGTNCDE---AFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDETH 846
Query: 836 SATAESSRLLDVPRYLC-EGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYES 894
+ +++S L+ Y E + PYQTGQLHPAIRVADLLQHI MK ++ YGFKEEYES
Sbjct: 847 TMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYES 906
Query: 895 FFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPS 954
FFEGQSA WD AKKD+NR KNRYGNIIAYDHSRV LQ +E D +SDYIN NYIDGY RP+
Sbjct: 907 FFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPN 966
Query: 955 HYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTC 1014
HYIATQGP+ ET+YDFWRM+W E +A I+MVTNLVEVGRVKC KYWPDDTE+Y D KVT
Sbjct: 967 HYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTL 1026
Query: 1015 VEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPP 1074
+E E LAEYV+RTF +E+RG +EIRE++QFHFTGWPDHGVPYHATGLL F+R+VK +PP
Sbjct: 1027 IETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPP 1086
Query: 1075 SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIF 1134
SAGP+VVHCSAGAGRTGC+IVIDIMLDMAEREGVVDIYNCV+ LRSRR+NMVQTEEQY+F
Sbjct: 1087 SAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVF 1146
Query: 1135 IHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCS 1194
IHDAILEACLCG+T++P + ++ Y+DM ++D QTNSS +K+EF+TLN VTP L+ EDCS
Sbjct: 1147 IHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCS 1206
Query: 1195 IACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPN 1254
IA LPRNH+KNR MD+LPPDRCLPFLITIDGESSNYINAALMDSY+QP+AFIVTQ+PLPN
Sbjct: 1207 IALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPN 1266
Query: 1255 TVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINR 1314
TVKDFWRLV DY CTS+VMLN+VD +Q CPQYWPE G+ R+GPIQVE +S ++ D+I+R
Sbjct: 1267 TVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISR 1326
Query: 1315 IFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTI 1374
IFRI N RPQ+GY MVQQFQ+LGW +R+ P SKRSFLKLI QV+KWQEE GEGRT+
Sbjct: 1327 IFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTV 1386
Query: 1375 IHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVAL 1434
+HCLNGGGRSG FCAI IV EM++ Q VDVFHAVKTLRN+KPNMV+ +QY+FCY+VAL
Sbjct: 1387 VHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVAL 1446
Query: 1435 EYLES 1439
EYL S
Sbjct: 1447 EYLNS 1451
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 1848 bits (4786), Expect = 0.0
Identities = 889/1458 (60%), Positives = 1096/1458 (75%), Gaps = 48/1458 (3%)
Query: 23 LLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDS 82
LL +A G+ +GGC FD+ C Y Q DDF W V+ P MP GS+M+V++
Sbjct: 14 LLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNA 73
Query: 83 SDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVT 142
S G++A L LP +KENDTHCIDF Y + S+ PG LN+ V+VN GPL NPIWN++
Sbjct: 74 SGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNIS 133
Query: 143 GFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLG 202
G R W RAELA+STFWPN YQVIFE ++ G GY+AID+++VL +PC ++PHFLR+
Sbjct: 134 GDPTRTWNRAELAISTFWPNFYQVIFEV-ITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQ 192
Query: 203 DVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTK 262
+VEVNAGQ ATFQC A GR ++LWLQ + D P+ + K + RRF ASF + TK
Sbjct: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
Query: 263 TDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGP 322
D YRC+ ++E G G+SN+A+L+V+EPP PIAPPQL VG TYL IQLNANSI GDGP
Sbjct: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
Query: 323 IILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLIT 382
I+ +EVEY SGSW + V++ +YK+ HLDPDTEYEI VLLTRPGEGGTG PGP L T
Sbjct: 313 IVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRT 372
Query: 383 RTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADC 442
RTKCA+PMR P+ L++ E+++R+I + WE GYN+TRCH++N+T+ Y Y G E +
Sbjct: 373 RTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREE 432
Query: 443 LDMDPKA--PQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQG 500
+ D + PQH + +L PYTNVS+K+IL NPEGRKES+E I+QTDED+PG VP +S+QG
Sbjct: 433 VSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQG 492
Query: 501 TSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMH 560
++FE KIFL W+EP G+IT YEI+Y ++ SFDP + ++ VS L N TH +F
Sbjct: 493 STFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFG 552
Query: 561 LHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPA 620
L+PGTTY F IRAST KGFGP TT ISAP++P YE ++ LN+T T+TV+L+PA
Sbjct: 553 LYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYE-LETPLNQTDNTVTVMLKPA 611
Query: 621 QAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLP 680
++GAP+S YQIVVEE P RTK+ ++CY VP+ +QNA + YYFAAE P +L
Sbjct: 612 HSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQ 671
Query: 681 EPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEV 740
PFT+GDN+TY G+WN PL P K Y IYFQA S ETK CV++ATK AAT +P
Sbjct: 672 AAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKP-- 729
Query: 741 IPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVN 800
+P+P KQTD VKIAG+ AGIL+F+++ L V+L++KK KLAKKRK+ M +TRQEMT MVN
Sbjct: 730 VPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVN 789
Query: 801 AMDRSYADQSTLHAEDPLSITFMDQHNFSPRY---------------------------- 832
+MD+SYA+Q T E + +FMD HN + R
Sbjct: 790 SMDKSYAEQGTNCDE---AFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFV 846
Query: 833 ----------ENHSATAESSRLLDVPRYLC-EGTESPYQTGQLHPAIRVADLLQHINLMK 881
E H+ +++S L+ Y E + PYQTGQLHPAIRVADLLQHI MK
Sbjct: 847 PTAILVPINDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMK 906
Query: 882 TSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDY 941
++ YGFKEEYESFFEGQSA WD AKKD+NR KNRYGNIIAYDHSRV LQ +E D +SDY
Sbjct: 907 CAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDY 966
Query: 942 INANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP 1001
IN NYIDGY RP+HYIATQGP+ ET+YDFWRM+W E +A I+MVTNLVEVGRVKC KYWP
Sbjct: 967 INGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP 1026
Query: 1002 DDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGL 1061
DDTE+Y D KVT +E E LAEYV+RTF +E+RG +EIRE++QFHFTGWPDHGVPYHATGL
Sbjct: 1027 DDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGL 1086
Query: 1062 LSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSR 1121
L F+R+VK +PPSAGP+VVHCSAGAGRTGC+IVIDIMLDMAEREGVVDIYNCV+ LRSR
Sbjct: 1087 LGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSR 1146
Query: 1122 RINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTL 1181
R+NMVQTEEQY+FIHDAILEACLCG+T++P + ++ Y+DM ++D QTNSS +K+EF+TL
Sbjct: 1147 RVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTL 1206
Query: 1182 NSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQ 1241
N VTP L+ EDCSIA LPRNH+KNR MD+LPPDRCLPFLITIDGESSNYINAALMDSY+Q
Sbjct: 1207 NMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQ 1266
Query: 1242 PAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVE 1301
P+AFIVTQ+PLPNTVKDFWRLV DY CTS+VMLN+VD +Q CPQYWPE G+ R+GPIQVE
Sbjct: 1267 PSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVE 1326
Query: 1302 CMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEK 1361
+S ++ D+I+RIFRI N RPQ+GY MVQQFQ+LGW +R+ P SKRSFLKLI QV+K
Sbjct: 1327 FVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDK 1386
Query: 1362 WQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVE 1421
WQEE GEGRT++HCLNGGGRSG FCAI IV EM++ Q VDVFHAVKTLRN+KPNMV+
Sbjct: 1387 WQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVD 1446
Query: 1422 APEQYRFCYDVALEYLES 1439
+QY+FCY+VALEYL S
Sbjct: 1447 LLDQYKFCYEVALEYLNS 1464
>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
precursor [Homo sapiens]
Length = 1436
Score = 1780 bits (4611), Expect = 0.0
Identities = 862/1417 (60%), Positives = 1068/1417 (75%), Gaps = 20/1417 (1%)
Query: 33 AGGCTFDDGPGA---CDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGE 89
A GCTF++ C+Y Q YDDF+W V P ++P GSY++V++S H PG+
Sbjct: 24 AAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQ 83
Query: 90 KARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDW 149
+A + ++ ENDTHC+ FSY LYS+ G +PGTL + VRVN GPL + +WN+TG GR W
Sbjct: 84 RAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQW 143
Query: 150 LRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAG 209
+AELAVSTFWPNEYQV+FEA +S R GY+ +DDI +LSYPC K+PHF RLGDVEVNAG
Sbjct: 144 HQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAG 203
Query: 210 QNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYR 269
QNA+FQC+A GR A + LQR++G +P A ++I+HRRF A+F L V++ +QDLYR
Sbjct: 204 QNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYR 263
Query: 270 CVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVE 329
CV+Q+ RG+GVSNFA+LIV+EPP PIAPPQLL GPTYL+IQLN NSIIGDGPI+ KE+E
Sbjct: 264 CVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIE 323
Query: 330 YRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEP 389
YRM G W E HAV+ TYKLWHLDPDTEYEI VLLTRPG+GGTG PGPPLI+RTKCAEP
Sbjct: 324 YRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEP 383
Query: 390 MRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRG--HNESKADCLDMDP 447
MR PK L AEIQAR++ + WE LGYN+TRCHT+ V++CYHY G HN++ +C+ +
Sbjct: 384 MRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQ 443
Query: 448 KAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKI 507
++ + +L PY NV ++++LTNPEGRKE +E QTDEDVP + +SL T E+ I
Sbjct: 444 GVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMI 503
Query: 508 FLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTY 567
FL W+EP +PNG+ITQYEISY SI S DPAV V GP +T+S L N T+HVF +LHPGTTY
Sbjct: 504 FLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTY 563
Query: 568 QFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPI 627
F +RA T KGFG A +TTNISAP+ DY + + L E+ TITVLLRPAQ +GAPI
Sbjct: 564 LFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPI 622
Query: 628 SAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTV 687
S YQ++VEE R +RE G +C+ VP+T++ A++ G +YF AEL +LPE PFTV
Sbjct: 623 SVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAMPFTV 682
Query: 688 GDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQ 747
GDN+TY+GFWNPPL PRK Y IYFQA S ++ ET+ C+RIA KAA E + + +++
Sbjct: 683 GDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPL-EVSQR 741
Query: 748 TDRVVKIAGISAG-ILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSY 806
++ + I GI AG + V ILLL +I+I++K K K A N RQE THM++A+DRS+
Sbjct: 742 SEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTK-ATVNYRQEKTHMMSAVDRSF 800
Query: 807 ADQSTLHAEDPLSITFMDQHNFSPRYENHSA--TAESSRLLDVPRYLCEGTESPYQTGQL 864
DQSTL ++ L ++FMD H +S R + S T SS L PR C SPY TGQL
Sbjct: 801 TDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQL 860
Query: 865 HPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYD 924
HPA+RVADLLQHIN MKT++ YGFK+EYESFFEG WD KK +R + AYD
Sbjct: 861 HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYD 916
Query: 925 HSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVM 984
RV L P+ DP++DYINANYIDGY R +H+IATQGP E VYDFWRM+WQE + IVM
Sbjct: 917 RHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVM 976
Query: 985 VTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQF 1044
+T LVEVGRVKC +YWP+D++ YGD K+ V+ E LAEYVVRTF LERRGY+ EV+QF
Sbjct: 977 ITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQF 1036
Query: 1045 HFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAE 1104
HFT WP+HGVPYHATGLL+FIRRVK S PP AGPIV+HCSAG GRTGCYIV+D+MLDMAE
Sbjct: 1037 HFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAE 1096
Query: 1105 REGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIR 1164
EGVVDIYNCVK L SRR+NM+QTEEQYIFIHDAILEACLCGET IPV EFKA Y +MIR
Sbjct: 1097 CEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIR 1156
Query: 1165 IDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITID 1224
ID Q+NSS L++EFQTLNSVTP L E+CSIA LPRN DKNR MD+LPPDRCLPFLI+ D
Sbjct: 1157 IDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTD 1216
Query: 1225 GESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQG-- 1282
G+S+NYINAAL DSY + AAFIVT +PL +T DFWRLVYDYGCTSIVMLN+++ S
Sbjct: 1217 GDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAW 1276
Query: 1283 -CPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWAS 1341
C QYWPE G +YG ++VE MS + D D++ R+FR+ N++R QEG+L+V+ FQ+L W++
Sbjct: 1277 PCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSA 1336
Query: 1342 HREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQN 1401
+R+ P SK++FL L+ +V+KWQ E G+GRTI+HCLNGGGRSG FCA V+EM++ N
Sbjct: 1337 YRDTPDSKKAFLHLLAEVDKWQ--AESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHN 1394
Query: 1402 VVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1438
+VDVF A KTLRN KPNMVE +QY FCYDVALEYLE
Sbjct: 1395 LVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1431
>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
precursor [Homo sapiens]
Length = 1442
Score = 1774 bits (4594), Expect = 0.0
Identities = 862/1423 (60%), Positives = 1068/1423 (75%), Gaps = 26/1423 (1%)
Query: 33 AGGCTFDDGPGA---CDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGE 89
A GCTF++ C+Y Q YDDF+W V P ++P GSY++V++S H PG+
Sbjct: 24 AAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQ 83
Query: 90 KARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDW 149
+A + ++ ENDTHC+ FSY LYS+ G +PGTL + VRVN GPL + +WN+TG GR W
Sbjct: 84 RAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQW 143
Query: 150 LRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAG 209
+AELAVSTFWPNEYQV+FEA +S R GY+ +DDI +LSYPC K+PHF RLGDVEVNAG
Sbjct: 144 HQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAG 203
Query: 210 QNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYR 269
QNA+FQC+A GR A + LQR++G +P A ++I+HRRF A+F L V++ +QDLYR
Sbjct: 204 QNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYR 263
Query: 270 CVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVE 329
CV+Q+ RG+GVSNFA+LIV+EPP PIAPPQLL GPTYL+IQLN NSIIGDGPI+ KE+E
Sbjct: 264 CVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIE 323
Query: 330 YRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEP 389
YRM G W E HAV+ TYKLWHLDPDTEYEI VLLTRPG+GGTG PGPPLI+RTKCAEP
Sbjct: 324 YRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEP 383
Query: 390 MRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRG--HNESKADCLDMDP 447
MR PK L AEIQAR++ + WE LGYN+TRCHT+ V++CYHY G HN++ +C+ +
Sbjct: 384 MRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQ 443
Query: 448 KAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKI 507
++ + +L PY NV ++++LTNPEGRKE +E QTDEDVP + +SL T E+ I
Sbjct: 444 GVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMI 503
Query: 508 FLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTY 567
FL W+EP +PNG+ITQYEISY SI S DPAV V GP +T+S L N T+HVF +LHPGTTY
Sbjct: 504 FLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTY 563
Query: 568 QFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPI 627
F +RA T KGFG A +TTNISAP+ DY + + L E+ TITVLLRPAQ +GAPI
Sbjct: 564 LFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPI 622
Query: 628 SAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTV 687
S YQ++VEE R +RE G +C+ VP+T++ A++ G +YF AEL +LPE PFTV
Sbjct: 623 SVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAMPFTV 682
Query: 688 GDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQ 747
GDN+TY+GFWNPPL PRK Y IYFQA S ++ ET+ C+RIA KAA E + + +++
Sbjct: 683 GDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPL-EVSQR 741
Query: 748 TDRVVKIAGISA-GILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSY 806
++ + I GI A G+ V ILLL +I+I++K K K A N RQE THM++A+DRS+
Sbjct: 742 SEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTK-ATVNYRQEKTHMMSAVDRSF 800
Query: 807 ADQSTLHAEDPLSITFMDQHNFSPRYENHS--ATAESSRLLDVPRYLCEGTESPYQTGQL 864
DQSTL ++ L ++FMD H +S R + S T SS L PR C SPY TGQL
Sbjct: 801 TDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQL 860
Query: 865 HPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYD 924
HPA+RVADLLQHIN MKT++ YGFK+EYESFFEG WD KK +R + AYD
Sbjct: 861 HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYD 916
Query: 925 HSRVILQPVEDDPSSDYINANYID------GYQRPSHYIATQGPVHETVYDFWRMIWQEQ 978
RV L P+ DP++DYINANYID GY R +H+IATQGP E VYDFWRM+WQE
Sbjct: 917 RHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEH 976
Query: 979 SACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEI 1038
+ IVM+T LVEVGRVKC +YWP+D++ YGD K+ V+ E LAEYVVRTF LERRGY+
Sbjct: 977 CSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR 1036
Query: 1039 REVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDI 1098
EV+QFHFT WP+HGVPYHATGLL+FIRRVK S PP AGPIV+HCSAG GRTGCYIV+D+
Sbjct: 1037 HEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDV 1096
Query: 1099 MLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAA 1158
MLDMAE EGVVDIYNCVK L SRR+NM+QTEEQYIFIHDAILEACLCGET IPV EFKA
Sbjct: 1097 MLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKAT 1156
Query: 1159 YFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLP 1218
Y +MIRID Q+NSS L++EFQTLNSVTP L E+CSIA LPRN DKNR MD+LPPDRCLP
Sbjct: 1157 YKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLP 1216
Query: 1219 FLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVD 1278
FLI+ DG+S+NYINAAL DSY + AAFIVT +PL +T DFWRLVYDYGCTSIVMLN+++
Sbjct: 1217 FLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLN 1276
Query: 1279 LSQG---CPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQ 1335
S C QYWPE G +YG ++VE MS + D D++ R+FR+ N++R QEG+L+V+ FQ
Sbjct: 1277 QSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQ 1336
Query: 1336 YLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVE 1395
+L W+++R+ P SK++FL L+ +V+KWQ E G+GRTI+HCLNGGGRSG FCA V+E
Sbjct: 1337 FLRWSAYRDTPDSKKAFLHLLAEVDKWQ--AESGDGRTIVHCLNGGGRSGTFCACATVLE 1394
Query: 1396 MVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1438
M++ N+VDVF A KTLRN KPNMVE +QY FCYDVALEYLE
Sbjct: 1395 MIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1437
>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
precursor [Homo sapiens]
Length = 1446
Score = 1773 bits (4592), Expect = 0.0
Identities = 860/1426 (60%), Positives = 1067/1426 (74%), Gaps = 28/1426 (1%)
Query: 33 AGGCTFDDGPGA---CDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGE 89
A GCTF++ C+Y Q YDDF+W V P ++P GSY++V++S H PG+
Sbjct: 24 AAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQ 83
Query: 90 KARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDW 149
+A + ++ ENDTHC+ FSY LYS+ G +PGTL + VRVN GPL + +WN+TG GR W
Sbjct: 84 RAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQW 143
Query: 150 LRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAG 209
+AELAVSTFWPNEYQV+FEA +S R GY+ +DDI +LSYPC K+PHF RLGDVEVNAG
Sbjct: 144 HQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAG 203
Query: 210 QNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYR 269
QNA+FQC+A GR A + LQR++G +P A ++I+HRRF A+F L V++ +QDLYR
Sbjct: 204 QNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYR 263
Query: 270 CVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVE 329
CV+Q+ RG+GVSNFA+LIV+EPP PIAPPQLL GPTYL+IQLN NSIIGDGPI+ KE+E
Sbjct: 264 CVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIE 323
Query: 330 YRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEP 389
YRM G W E HAV+ TYKLWHLDPDTEYEI VLLTRPG+GGTG PGPPLI+RTKCAEP
Sbjct: 324 YRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEP 383
Query: 390 MRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRG--HNESKADCLDMDP 447
MR PK L AEIQAR++ + WE LGYN+TRCHT+ V++CYHY G HN++ +C+ +
Sbjct: 384 MRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQ 443
Query: 448 KAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKI 507
++ + +L PY NV ++++LTNPEGRKE +E QTDEDVP + +SL T E+ I
Sbjct: 444 GVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMI 503
Query: 508 FLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTY 567
FL W+EP +PNG+ITQYEISY SI S DPAV V GP +T+S L N T+HVF +LHPGTTY
Sbjct: 504 FLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTY 563
Query: 568 QFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPI 627
F +RA T KGFG A +TTNISAP+ DY + + L E+ TITVLLRPAQ +GAPI
Sbjct: 564 LFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPI 622
Query: 628 SAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTV 687
S YQ++VEE R +RE G +C+ VP+T++ A++ G +YF AEL +LPE PFTV
Sbjct: 623 SVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAMPFTV 682
Query: 688 GDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQ 747
GDN+TY+GFWNPPL PRK Y IYFQA S ++ ET+ C+RIA KAA E + + +++
Sbjct: 683 GDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPL-EVSQR 741
Query: 748 TDRVVKIAGISAG-ILVFILLLLVVILIVKKSK---------LAKKRKDAMGNTRQEMTH 797
++ + I GI AG + V ILLL +I+I++K + A N RQE TH
Sbjct: 742 SEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYSYYPKPVNMTKATVNYRQEKTH 801
Query: 798 MVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSA--TAESSRLLDVPRYLCEGT 855
M++A+DRS+ DQSTL ++ L ++FMD H +S R + S T SS L PR C
Sbjct: 802 MMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRK 861
Query: 856 ESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKN 915
SPY TGQLHPA+RVADLLQHIN MKT++ YGFK+EYESFFEG WD KK +
Sbjct: 862 GSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGS 917
Query: 916 RYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIW 975
R + AYD RV L P+ DP++DYINANYIDGY R +H+IATQGP E VYDFWRM+W
Sbjct: 918 RQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVW 977
Query: 976 QEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGY 1035
QE + IVM+T LVEVGRVKC +YWP+D++ YGD K+ V+ E LAEYVVRTF LERRGY
Sbjct: 978 QEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGY 1037
Query: 1036 NEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIV 1095
+ EV+QFHFT WP+HGVPYHATGLL+FIRRVK S PP AGPIV+HCSAG GRTGCYIV
Sbjct: 1038 SARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIV 1097
Query: 1096 IDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEF 1155
+D+MLDMAE EGVVDIYNCVK L SRR+NM+QTEEQYIFIHDAILEACLCGET IPV EF
Sbjct: 1098 LDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEF 1157
Query: 1156 KAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDR 1215
KA Y +MIRID Q+NSS L++EFQTLNSVTP L E+CSIA LPRN DKNR MD+LPPDR
Sbjct: 1158 KATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR 1217
Query: 1216 CLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLN 1275
CLPFLI+ DG+S+NYINAAL DSY + AAFIVT +PL +T DFWRLVYDYGCTSIVMLN
Sbjct: 1218 CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLN 1277
Query: 1276 EVDLSQG---CPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQ 1332
+++ S C QYWPE G +YG ++VE MS + D D++ R+FR+ N++R QEG+L+V+
Sbjct: 1278 QLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVR 1337
Query: 1333 QFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGI 1392
FQ+L W+++R+ P SK++FL L+ +V+KWQ E G+GRTI+HCLNGGGRSG FCA
Sbjct: 1338 HFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQ--AESGDGRTIVHCLNGGGRSGTFCACAT 1395
Query: 1393 VVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1438
V+EM++ N+VDVF A KTLRN KPNMVE +QY FCYDVALEYLE
Sbjct: 1396 VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1441
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 1767 bits (4577), Expect = 0.0
Identities = 846/1450 (58%), Positives = 1087/1450 (74%), Gaps = 21/1450 (1%)
Query: 1 MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDL-YDDFEWVH 59
M + AA AL +LLL P L A+ Q +AGGC+FD+ C Y L + F W
Sbjct: 1 MASLAALAL----SLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQ 56
Query: 60 VSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLN 119
++ E L +P GS+M+V+SS G+KA L LPT+KENDTHCIDF Y S+ +
Sbjct: 57 INTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSS 116
Query: 120 PGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGY 179
PG LN+ V+VN GP NP+WNV+G W++AELA+STFWP+ YQVIFE+ G GY
Sbjct: 117 PGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGY 176
Query: 180 IAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIP 239
IA+D+++VL++PC K+PHFLRL +VEVN GQNATFQCIA G+ + H+KLWLQ+ NG D
Sbjct: 177 IAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTA 236
Query: 240 VAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQ 299
+ T+ +NHRRF+A+ + + + YRCV +S+ GSGVSN+A+LIV+EPP PIAPP+
Sbjct: 237 LMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE 296
Query: 300 LLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEY 359
LL VG TYL I+ NANSIIGDGPIILKEVEYR T+G+W ETH V++P YKLWHLDPD EY
Sbjct: 297 LLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEY 356
Query: 360 EIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITR 419
EIRVLLTRPGEGGTG PGPPL TRTKCA+P+ P+ ++I +I+AR++ + WE GY +TR
Sbjct: 357 EIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTR 416
Query: 420 CHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESE 479
CH++N+T+ Y Y N+ + + ++ + + + L P+ + L+++L+NPEGR ESE
Sbjct: 417 CHSYNLTVQYQYV--FNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE 474
Query: 480 ETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVP 539
E ++QT+EDVPG VP++S+QG FE KI++ WK P + NG+IT YEI+Y ++ S DP+
Sbjct: 475 ELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSAD 534
Query: 540 VAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDY 599
++ V L N THH+F+ L+PGTTY F I+AST KGFGP + T ISAP++P+Y
Sbjct: 535 LSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEY 594
Query: 600 EGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQ 659
+ D LNET TTITV+L+PAQ++GAP+S YQ+VV+E +++R A +EC+ VPV+Y+
Sbjct: 595 D-TDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
Query: 660 NAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEK 719
NA S + +YFAAEL P NLP PFTVGDN+TY G+WNPPL+P K Y+IYFQA+S
Sbjct: 654 NASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANG 713
Query: 720 ETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKS- 778
ETK CVR+ATK A+T+ + +P KQ D VK+AG+ AG+L+FI++LL V+L +K+
Sbjct: 714 ETKINCVRLATKGASTQNSNTV-EPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRR 772
Query: 779 ---------KLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFS 829
KLAKK+K+ ++EM + +A D+ S ++ S + D + F+
Sbjct: 773 NAYSYSYYLKLAKKQKETQSGAQREMGPVASA-DKPTTKLSASRNDEGFSSSSQDVNGFT 831
Query: 830 PRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFK 889
+ + + P C+ E Y Q PAIRVADLLQHI MK YGFK
Sbjct: 832 DGSRGE-LSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFK 890
Query: 890 EEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDG 949
EEYE+ EGQ+ASWD AK+D+NR KNRYGNII+YDHSRV L ++ DP SDYINANYIDG
Sbjct: 891 EEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDG 950
Query: 950 YQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGD 1009
Y RP HYIATQGP+ ETV DFWRMIWQE SA IVMVTNLVEVGRVKC +YWPDDTEVYGD
Sbjct: 951 YHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGD 1010
Query: 1010 FKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVK 1069
KVT +E EPLAEYV+RTFT++++GY+EIRE++ FHFT WPDHGVP +ATGLL F+R+VK
Sbjct: 1011 IKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVK 1070
Query: 1070 LSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTE 1129
NPP AGPIVVHCSAGAGRTGC+I ID MLDMAE EGVVDI+NCV+ LR++R+N+VQTE
Sbjct: 1071 FLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTE 1130
Query: 1130 EQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQ 1189
EQY+F+HDAILEACLCG TAIPVCEF++ Y+++ R+D QTNSS +KDEFQTLN VTPR++
Sbjct: 1131 EQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVR 1190
Query: 1190 AEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQ 1249
EDCSI LPRNHDKNR MD+LP DRCLPFLI++DGESSNYINAALMDS++QPAAF+VTQ
Sbjct: 1191 PEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQ 1250
Query: 1250 YPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDC 1309
+PLPNTV DFWRLV+DY C+S+VMLNE+D +Q C QYWPE+ YGPIQVE +S +D
Sbjct: 1251 HPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDE 1310
Query: 1310 DVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEG 1369
D+I+RIFRICN+ RPQ+GY +VQ QY+GW ++R+ P SKRS LK++ ++EKWQE+ +
Sbjct: 1311 DIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGR 1370
Query: 1370 EGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFC 1429
EGRT++HCLNGGGRSG FCAI V EM+++QN++DVFH VKTLRN+K NMVE EQY+F
Sbjct: 1371 EGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFV 1430
Query: 1430 YDVALEYLES 1439
Y+VALEYL S
Sbjct: 1431 YEVALEYLSS 1440
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 1757 bits (4551), Expect = 0.0
Identities = 847/1469 (57%), Positives = 1088/1469 (74%), Gaps = 40/1469 (2%)
Query: 1 MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDL-YDDFEWVH 59
M + AA AL +LLL P L A+ Q +AGGC+FD+ C Y L + F W
Sbjct: 1 MASLAALAL----SLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQ 56
Query: 60 VSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLN 119
++ E L +P GS+M+V+SS G+KA L LPT+KENDTHCIDF Y S+ +
Sbjct: 57 INTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSS 116
Query: 120 PGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGY 179
PG LN+ V+VN GP NP+WNV+G W++AELA+STFWP+ YQVIFE+ G GY
Sbjct: 117 PGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGY 176
Query: 180 IAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIP 239
IA+D+++VL++PC K+PHFLRL +VEVN GQNATFQCIA G+ + H+KLWLQ+ NG D
Sbjct: 177 IAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTA 236
Query: 240 VAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQ 299
+ T+ +NHRRF+A+ + + + YRCV +S+ GSGVSN+A+LIV+EPP PIAPP+
Sbjct: 237 LMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE 296
Query: 300 LLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEY 359
LL VG TYL I+ NANSIIGDGPIILKEVEYR T+G+W ETH V++P YKLWHLDPD EY
Sbjct: 297 LLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEY 356
Query: 360 EIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITR 419
EIRVLLTRPGEGGTG PGPPL TRTKCA+P+ P+ ++I +I+AR++ + WE GY +TR
Sbjct: 357 EIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTR 416
Query: 420 CHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESE 479
CH++N+T+ Y Y N+ + + ++ + + + L P+ + L+++L+NPEGR ESE
Sbjct: 417 CHSYNLTVQYQYV--FNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE 474
Query: 480 ETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVP 539
E ++QT+EDVPG VP++S+QG FE KI++ WK P + NG+IT YEI+Y ++ S DP+
Sbjct: 475 ELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSAD 534
Query: 540 VAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDY 599
++ V L N THH+F+ L+PGTTY F I+AST KGFGP + T ISAP++P+Y
Sbjct: 535 LSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEY 594
Query: 600 EGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQ 659
+ D LNET TTITV+L+PAQ++GAP+S YQ+VV+E +++R A +EC+ VPV+Y+
Sbjct: 595 D-TDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
Query: 660 NAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEK 719
NA S + +YFAAEL P NLP PFTVGDN+TY G+WNPPL+P K Y+IYFQA+S
Sbjct: 654 NASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANG 713
Query: 720 ETKTQCVRIATKA-------------------AATEEPEVIPDPAKQTDRVVKIAGISAG 760
ETK CVR+ATKA A+T+ + +P KQ D VK+AG+ AG
Sbjct: 714 ETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTV-EPEKQVDNTVKMAGVIAG 772
Query: 761 ILVFILLLLVVILIVKKS----------KLAKKRKDAMGNTRQEMTHMVNAMDRSYADQS 810
+L+FI++LL V+L +K+ KLAKK+K+ ++EM + +A D+ S
Sbjct: 773 LLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASA-DKPTTKLS 831
Query: 811 TLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRV 870
++ S + D + F+ + + + P C+ E Y Q PAIRV
Sbjct: 832 ASRNDEGFSSSSQDVNGFTDGSRGE-LSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRV 890
Query: 871 ADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVIL 930
ADLLQHI MK YGFKEEYE+ EGQ+ASWD AK+D+NR KNRYGNII+YDHSRV L
Sbjct: 891 ADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRL 950
Query: 931 QPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVE 990
++ DP SDYINANYIDGY RP HYIATQGP+ ETV DFWRMIWQE SA IVMVTNLVE
Sbjct: 951 LVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVE 1010
Query: 991 VGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWP 1050
VGRVKC +YWPDDTEVYGD KVT +E EPLAEYV+RTFT++++GY+EIRE++ FHFT WP
Sbjct: 1011 VGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWP 1070
Query: 1051 DHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVD 1110
DHGVP +ATGLL F+R+VK NPP AGPIVVHCSAGAGRTGC+I ID MLDMAE EGVVD
Sbjct: 1071 DHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVD 1130
Query: 1111 IYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTN 1170
I+NCV+ LR++R+N+VQTEEQY+F+HDAILEACLCG TAIPVCEF++ Y+++ R+D QTN
Sbjct: 1131 IFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTN 1190
Query: 1171 SSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNY 1230
SS +KDEFQTLN VTPR++ EDCSI LPRNHDKNR MD+LP DRCLPFLI++DGESSNY
Sbjct: 1191 SSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNY 1250
Query: 1231 INAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEE 1290
INAALMDS++QPAAF+VTQ+PLPNTV DFWRLV+DY C+S+VMLNE+D +Q C QYWPE+
Sbjct: 1251 INAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEK 1310
Query: 1291 GMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKR 1350
YGPIQVE +S +D D+I+RIFRICN+ RPQ+GY +VQ QY+GW ++R+ P SKR
Sbjct: 1311 TSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKR 1370
Query: 1351 SFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVK 1410
S LK++ ++EKWQE+ + EGRT++HCLNGGGRSG FCAI V EM+++QN++DVFH VK
Sbjct: 1371 SLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVK 1430
Query: 1411 TLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
TLRN+K NMVE EQY+F Y+VALEYL S
Sbjct: 1431 TLRNNKSNMVETLEQYKFVYEVALEYLSS 1459
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 521 bits (1341), Expect = e-147
Identities = 379/1141 (33%), Positives = 563/1141 (49%), Gaps = 141/1141 (12%)
Query: 335 GSWTETHAVNAPTYKLWHLDPDTEYEIRVL-LTRPGEGGTGLPGPPLITRTKCAEPMRTP 393
G+W + + ++ + L D Y +RVL T G+G P+ +T+ P + P
Sbjct: 464 GNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLS---DPIQVKTQQGVPGQ-P 519
Query: 394 KTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHV 453
L+ I + W ++ FR + + DP +V
Sbjct: 520 MNLRAEARSETSITLSWSPPRQE-------SIIKYELLFREGDHGREVGRTFDPTT-SYV 571
Query: 454 VNHLPPYTNVSLKMILTNPEGRKESEETIIQ-TDEDV-PGPVPVKSLQGTSFENKIFLNW 511
V L P T + ++ +P+G + Q T + + P VK + TS + L+W
Sbjct: 572 VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTS----VLLSW 627
Query: 512 KEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFI 571
+ P + N T Y+I Y+ + T+ +T + HL P T Y F +
Sbjct: 628 EFPDNYNSP-TPYKIQYNGL--------------TLDVDGRTTKKLITHLKPHTFYNFVL 672
Query: 572 --RASTVKGFGPATAINVTTNI-----SAPTLPDYEGVDASLNETATTITVLLRPAQAKG 624
R S++ G N+ S PD +G I V L Q+
Sbjct: 673 TNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF----------IMVYLPDGQSP- 721
Query: 625 APISAYQIVVEELHPHRTKR---EAGAMECYQVPVTYQNA-------------MSGGAPY 668
P+ +Y IV+ L R + G+ E + Q+ + PY
Sbjct: 722 VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPY 781
Query: 669 YFA--AELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCV 726
A + LPP F GD + Y GF N L P Y ++ A+ + T
Sbjct: 782 IAARFSVLPP-------TFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFA--- 831
Query: 727 RIATKAAATEEPEVI--PDPAKQTDRVVKIAGISAGILVFILLLLVVI-LIVKKSKLAKK 783
A+ +P + PDP D + + +L + ++ +VI +++ K+K K
Sbjct: 832 -----ASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSK 886
Query: 784 RKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSR 843
RKD+ T+ + + AD + H +DP+ M + NF
Sbjct: 887 RKDSEPRTKCLLNN---------ADLAPHHPKDPVE---MRRINFQ-------------- 920
Query: 844 LLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASW 903
P L HP I +AD+ +H +K +DS +EYES GQ +W
Sbjct: 921 ---TPGMLS------------HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTW 965
Query: 904 DVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPV 963
+ + + N+ KNRY N+IAYDHSRVILQP+E SDYINANY+DGY+ + YIATQGP+
Sbjct: 966 EHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPL 1025
Query: 964 HETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAE 1022
ET DFWRM+W+++SA IVM+T L E R+KC +YWP+ TE YG +VT ++ LA
Sbjct: 1026 PETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELAT 1085
Query: 1023 YVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVH 1082
+ VRTF+L + G +E REV+QF FT WPDHGVP + T L+F+RRVK NPP AGPIVVH
Sbjct: 1086 FCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVH 1145
Query: 1083 CSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEA 1142
CSAG GRTGC+IVID ML+ + E VD+Y V +RS+R MVQTE+QY FIH+A+LEA
Sbjct: 1146 CSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA 1205
Query: 1143 CLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNH 1202
CG T +P A + +++ + + ++ EF+ L + A LP N
Sbjct: 1206 VGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLPCNK 1263
Query: 1203 DKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWR 1261
KNR ++++P + L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR
Sbjct: 1264 FKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWR 1323
Query: 1262 LVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRIC 1319
++++ T +VML ++ + C QYWP E RY V+ M+ + ++ I R
Sbjct: 1324 MLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREF 1380
Query: 1320 NLTRPQEGY-LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCL 1378
+T ++G V+QFQ+ W + VP S F+ I QV K +E+ + +G +HC
Sbjct: 1381 KVTDARDGQSRTVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCS 1438
Query: 1379 NGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1438
G GR+G+F + IV+E ++ + VVD+F VK LR +P MV+ ++Y+FCY ALEYL
Sbjct: 1439 AGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG 1498
Query: 1439 S 1439
S
Sbjct: 1499 S 1499
Score = 66.6 bits (161), Expect = 2e-10
Identities = 91/402 (22%), Positives = 150/402 (37%), Gaps = 69/402 (17%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRNG----EDIPVAQTKNINHRRFAASFRLQEV 260
E+ G N C+A G + K W+Q +D+PV +N+ L+
Sbjct: 246 EIMPGGNVNITCVAVGSPMPYVK-WMQGAEDLTPEDDMPVG--RNV----------LELT 292
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
D Y CV S G + AQ+ V+ P+ P + T + I ++ +
Sbjct: 293 DVKDSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---P 348
Query: 321 GPIILKEVEYRMTS--GSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ +EY+ S G + + Y + L P++EYEI V + G G P
Sbjct: 349 DPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSE 406
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
++TRT P P+ ++ + A + V WE GY + +T
Sbjct: 407 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRV--YYTMEPEHPVG 464
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP 490
++ HN +D V + L T + T+ S+ ++T + VP
Sbjct: 465 NWQKHN--------VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP 516
Query: 491 GPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSS-------IRSFDPAVPVAGP 543
G P+ E I L+W P + I +YE+ + R+FDP
Sbjct: 517 GQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP------- 566
Query: 544 PQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAI 585
+T +V L P T Y F + A + +G G T +
Sbjct: 567 ---------TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV 599
Score = 47.4 bits (111), Expect = 1e-04
Identities = 96/449 (21%), Positives = 167/449 (37%), Gaps = 59/449 (13%)
Query: 206 VNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQ 265
V + AT C A+G W + D P A I R A +++ +TDQ
Sbjct: 146 VERTRTATMLCAASGNPDPEIT-WFKDFLPVD-PSASNGRIKQLRSGA-LQIESSEETDQ 202
Query: 266 DLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIIL 325
Y CV + G S+ A L VRE ++ V P + ++ ++ + I+ G + +
Sbjct: 203 GKYECVATNSAGVRYSSPANLYVRELR------EVRRVAPRFSILPMS-HEIMPGGNVNI 255
Query: 326 KEVEYRMTSGSWTETHAVNAPT-YKLW-----HLDPDTEYEI--RVL-LTRPGEGG---- 372
V AV +P Y W L P+ + + VL LT +
Sbjct: 256 TCV-------------AVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTC 302
Query: 373 ---TGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICY 429
+ L + + + P T + E A I + W+S + +
Sbjct: 303 VAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIE----- 357
Query: 430 HYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDED 488
++ ++ + D ++ + L P + + + N G+ SE + +T E
Sbjct: 358 --YKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQ 415
Query: 489 VPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVS 548
P P + + W+EP++PNG+I Y + Y + +P PV +
Sbjct: 416 APASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYY----TMEPEHPVGNWQK--H 469
Query: 549 NLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP-ATAINVTTNISAPTLPDYEGVDASLN 607
N+ +S L TY + A T G GP + I V T P P +A
Sbjct: 470 NVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA--- 526
Query: 608 ETATTITVLLRPAQAKGAPISAYQIVVEE 636
+ T+IT+ P + + I Y+++ E
Sbjct: 527 RSETSITLSWSPPRQES--IIKYELLFRE 553
Score = 32.3 bits (72), Expect = 3.4
Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 193 DKSPHFLRLGDVEVN-AGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRF 251
++ P F++ ++ +G A+F C ATG D W + G+ + + + I
Sbjct: 30 EEPPRFIKEPKDQIGVSGGVASFVCQATG-DPKPRVTW--NKKGKKVNSQRFETIEFDES 86
Query: 252 A-ASFRLQEV-TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLL 309
A A R+Q + T D+++Y CV Q+ G + ++RE P P + +GP +
Sbjct: 87 AGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPN-IDMGPQLKV 145
Query: 310 IQ 311
++
Sbjct: 146 VE 147
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 521 bits (1341), Expect = e-147
Identities = 379/1141 (33%), Positives = 563/1141 (49%), Gaps = 141/1141 (12%)
Query: 335 GSWTETHAVNAPTYKLWHLDPDTEYEIRVL-LTRPGEGGTGLPGPPLITRTKCAEPMRTP 393
G+W + + ++ + L D Y +RVL T G+G P+ +T+ P + P
Sbjct: 460 GNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLS---DPIQVKTQQGVPGQ-P 515
Query: 394 KTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHV 453
L+ I + W ++ FR + + DP +V
Sbjct: 516 MNLRAEARSETSITLSWSPPRQE-------SIIKYELLFREGDHGREVGRTFDPTT-SYV 567
Query: 454 VNHLPPYTNVSLKMILTNPEGRKESEETIIQ-TDEDV-PGPVPVKSLQGTSFENKIFLNW 511
V L P T + ++ +P+G + Q T + + P VK + TS + L+W
Sbjct: 568 VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTS----VLLSW 623
Query: 512 KEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFI 571
+ P + N T Y+I Y+ + T+ +T + HL P T Y F +
Sbjct: 624 EFPDNYNSP-TPYKIQYNGL--------------TLDVDGRTTKKLITHLKPHTFYNFVL 668
Query: 572 --RASTVKGFGPATAINVTTNI-----SAPTLPDYEGVDASLNETATTITVLLRPAQAKG 624
R S++ G N+ S PD +G I V L Q+
Sbjct: 669 TNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF----------IMVYLPDGQSP- 717
Query: 625 APISAYQIVVEELHPHRTKR---EAGAMECYQVPVTYQNA-------------MSGGAPY 668
P+ +Y IV+ L R + G+ E + Q+ + PY
Sbjct: 718 VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPY 777
Query: 669 YFA--AELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCV 726
A + LPP F GD + Y GF N L P Y ++ A+ + T
Sbjct: 778 IAARFSVLPP-------TFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFA--- 827
Query: 727 RIATKAAATEEPEVI--PDPAKQTDRVVKIAGISAGILVFILLLLVVI-LIVKKSKLAKK 783
A+ +P + PDP D + + +L + ++ +VI +++ K+K K
Sbjct: 828 -----ASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSK 882
Query: 784 RKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSR 843
RKD+ T+ + + AD + H +DP+ M + NF
Sbjct: 883 RKDSEPRTKCLLNN---------ADLAPHHPKDPVE---MRRINFQ-------------- 916
Query: 844 LLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASW 903
P L HP I +AD+ +H +K +DS +EYES GQ +W
Sbjct: 917 ---TPGMLS------------HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTW 961
Query: 904 DVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPV 963
+ + + N+ KNRY N+IAYDHSRVILQP+E SDYINANY+DGY+ + YIATQGP+
Sbjct: 962 EHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPL 1021
Query: 964 HETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAE 1022
ET DFWRM+W+++SA IVM+T L E R+KC +YWP+ TE YG +VT ++ LA
Sbjct: 1022 PETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELAT 1081
Query: 1023 YVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVH 1082
+ VRTF+L + G +E REV+QF FT WPDHGVP + T L+F+RRVK NPP AGPIVVH
Sbjct: 1082 FCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVH 1141
Query: 1083 CSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEA 1142
CSAG GRTGC+IVID ML+ + E VD+Y V +RS+R MVQTE+QY FIH+A+LEA
Sbjct: 1142 CSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA 1201
Query: 1143 CLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNH 1202
CG T +P A + +++ + + ++ EF+ L + A LP N
Sbjct: 1202 VGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLPCNK 1259
Query: 1203 DKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWR 1261
KNR ++++P + L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR
Sbjct: 1260 FKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWR 1319
Query: 1262 LVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRIC 1319
++++ T +VML ++ + C QYWP E RY V+ M+ + ++ I R
Sbjct: 1320 MLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREF 1376
Query: 1320 NLTRPQEGY-LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCL 1378
+T ++G V+QFQ+ W + VP S F+ I QV K +E+ + +G +HC
Sbjct: 1377 KVTDARDGQSRTVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCS 1434
Query: 1379 NGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1438
G GR+G+F + IV+E ++ + VVD+F VK LR +P MV+ ++Y+FCY ALEYL
Sbjct: 1435 AGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG 1494
Query: 1439 S 1439
S
Sbjct: 1495 S 1495
Score = 66.6 bits (161), Expect = 2e-10
Identities = 91/402 (22%), Positives = 150/402 (37%), Gaps = 69/402 (17%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRNG----EDIPVAQTKNINHRRFAASFRLQEV 260
E+ G N C+A G + K W+Q +D+PV +N+ L+
Sbjct: 242 EIMPGGNVNITCVAVGSPMPYVK-WMQGAEDLTPEDDMPVG--RNV----------LELT 288
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
D Y CV S G + AQ+ V+ P+ P + T + I ++ +
Sbjct: 289 DVKDSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---P 344
Query: 321 GPIILKEVEYRMTS--GSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ +EY+ S G + + Y + L P++EYEI V + G G P
Sbjct: 345 DPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSE 402
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
++TRT P P+ ++ + A + V WE GY + +T
Sbjct: 403 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRV--YYTMEPEHPVG 460
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP 490
++ HN +D V + L T + T+ S+ ++T + VP
Sbjct: 461 NWQKHN--------VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP 512
Query: 491 GPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSS-------IRSFDPAVPVAGP 543
G P+ E I L+W P + I +YE+ + R+FDP
Sbjct: 513 GQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP------- 562
Query: 544 PQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAI 585
+T +V L P T Y F + A + +G G T +
Sbjct: 563 ---------TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV 595
Score = 46.2 bits (108), Expect = 2e-04
Identities = 53/248 (21%), Positives = 96/248 (38%), Gaps = 20/248 (8%)
Query: 391 RTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAP 450
+ P T + E A I + W+S + + ++ ++ + D
Sbjct: 320 KAPGTPMVTENTATSITITWDSGNPDPVSYYVIE-------YKSKSQDGPYQIKEDITTT 372
Query: 451 QHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFL 509
++ + L P + + + N G+ SE + +T E P P + +
Sbjct: 373 RYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIV 432
Query: 510 NWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQF 569
W+EP++PNG+I Y + Y + +P PV + N+ +S L TY
Sbjct: 433 QWEEPVEPNGLIRGYRVYY----TMEPEHPVGNWQK--HNVDDSLLTTVGSLLEDETYTV 486
Query: 570 FIRASTVKGFGP-ATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPIS 628
+ A T G GP + I V T P P +A + T+IT+ P + + I
Sbjct: 487 RVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA---RSETSITLSWSPPRQES--II 541
Query: 629 AYQIVVEE 636
Y+++ E
Sbjct: 542 KYELLFRE 549
Score = 32.3 bits (72), Expect = 3.4
Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 193 DKSPHFLRLGDVEVN-AGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRF 251
++ P F++ ++ +G A+F C ATG D W + G+ + + + I
Sbjct: 30 EEPPRFIKEPKDQIGVSGGVASFVCQATG-DPKPRVTW--NKKGKKVNSQRFETIEFDES 86
Query: 252 A-ASFRLQEV-TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLL 309
A A R+Q + T D+++Y CV Q+ G + ++RE P P + +GP +
Sbjct: 87 AGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPN-IDMGPQLKV 145
Query: 310 IQ 311
++
Sbjct: 146 VE 147
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 516 bits (1330), Expect = e-146
Identities = 352/994 (35%), Positives = 514/994 (51%), Gaps = 124/994 (12%)
Query: 486 DEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQ 545
D+ P VK + TS + L+W+ P + N T Y+I Y+ +
Sbjct: 1033 DQVSPKNFKVKMIMKTS----VLLSWEFPDNYNSP-TPYKIQYNGL-------------- 1073
Query: 546 TVSNLWNSTHHVFMHLHPGTTYQFFI--RASTVKGFGPATAINVTTNI-----SAPTLPD 598
T+ +T + HL P T Y F + R S++ G N+ S PD
Sbjct: 1074 TLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPD 1133
Query: 599 YEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKR---EAGAMECYQVP 655
+G I V L Q+ P+ +Y IV+ L R + G+ E +
Sbjct: 1134 ADGF----------IMVYLPDGQSP-VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLE 1182
Query: 656 VTYQNA-------------MSGGAPYYFA--AELPPGNLPEPAPFTVGDNRTYQGFWNPP 700
Q+ + PY A + LPP F GD + Y GF N
Sbjct: 1183 ELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPP-------TFHPGDQKQYGGFDNRG 1235
Query: 701 LAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI--PDPAKQTDRVVKIAGIS 758
L P Y ++ A+ + T A+ +P + PDP D + +
Sbjct: 1236 LEPGHRYVLFVLAVLQKSEPTFA--------ASPFSDPFQLDNPDPQPIVDGEEGLIWVI 1287
Query: 759 AGILVFILLLLVVI-LIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDP 817
+L + ++ +VI +++ K+K KRKD+ T+ + + AD + H +DP
Sbjct: 1288 GPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN---------ADLAPHHPKDP 1338
Query: 818 LSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP-------YQTGQLHPAIRV 870
+ M + NF T +S G SP +++ HP I +
Sbjct: 1339 VE---MRRINFQ--------TPDS------------GLRSPLREPGFHFESMLSHPPIPI 1375
Query: 871 ADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVIL 930
AD+ +H +K +DS +EYES GQ +W+ + + N+ KNRY N+IAYDHSRVIL
Sbjct: 1376 ADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVIL 1435
Query: 931 QPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVE 990
QP+E SDYINANY+DGY+ + YIATQGP+ ET DFWRM+W+++SA IVM+T L E
Sbjct: 1436 QPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEE 1495
Query: 991 VGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGW 1049
R+KC +YWP+ TE YG +VT ++ LA + VRTF+L + G +E REV+QF FT W
Sbjct: 1496 KSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAW 1555
Query: 1050 PDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVV 1109
PDHGVP + T L+F+RRVK NPP AGPIVVHCSAG GRTGC+IVID ML+ + E V
Sbjct: 1556 PDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTV 1615
Query: 1110 DIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQT 1169
D+Y V +RS+R MVQTE+QY FIH+A+LEA CG T +P A + +++
Sbjct: 1616 DVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGE 1675
Query: 1170 NSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESS 1228
+ + ++ EF+ L + A LP N KNR ++++P + L I G E S
Sbjct: 1676 HVTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS 1733
Query: 1229 NYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQY 1286
+YINA+ +D YRQ A+I TQ PL T +DFWR++++ T +VML ++ + C QY
Sbjct: 1734 DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQY 1793
Query: 1287 WPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY-LMVQQFQYLGWASHREV 1345
WP E RY V+ M+ + ++ I R +T ++G V+QFQ+ W + V
Sbjct: 1794 WPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQSRTVRQFQFTDW-PEQGV 1849
Query: 1346 PGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDV 1405
P S F+ I QV K +E+ + +G +HC G GR+G+F + IV+E ++ + VVD+
Sbjct: 1850 PKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDI 1908
Query: 1406 FHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
F VK LR +P MV+ ++Y+FCY ALEYL S
Sbjct: 1909 FQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1942
Score = 72.8 bits (177), Expect = 2e-12
Identities = 100/450 (22%), Positives = 167/450 (37%), Gaps = 70/450 (15%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRNG----EDIPVAQTKNINHRRFAASFRLQEV 260
E+ G N C+A G + K W+Q +D+PV +N+ L+
Sbjct: 255 EIMPGGNVNITCVAVGSPMPYVK-WMQGAEDLTPEDDMPVG--RNV----------LELT 301
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
D Y CV S G + AQ+ V+ P+ P + T + I ++ +
Sbjct: 302 DVKDSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---P 357
Query: 321 GPIILKEVEYRMTS--GSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ +EY+ S G + + Y + L P++EYEI V + G G P
Sbjct: 358 DPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSE 415
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
++TRT P P+ ++ + A + V WE GY + +T
Sbjct: 416 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRV--YYTMEPEHPVG 473
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP 490
++ HN +D V + L T + T+ S+ ++T + VP
Sbjct: 474 NWQKHN--------VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP 525
Query: 491 GPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSS-------IRSFDPAVPVAGP 543
G P+ E I L+W P + I +YE+ + R+FDP
Sbjct: 526 GQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP------- 575
Query: 544 PQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPAT-AINVTTNISAPTLPDYEGV 602
+T +V L P T Y F + A + +G G T + T S P+ P +
Sbjct: 576 ---------TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVK 626
Query: 603 DASLNETATTITVLLRPAQAKGAPISAYQI 632
S+ TA ++ P + + Y +
Sbjct: 627 CVSVRSTAILVSWRPPPPETHNGALVGYSV 656
Score = 62.0 bits (149), Expect = 4e-09
Identities = 62/277 (22%), Positives = 104/277 (37%), Gaps = 23/277 (8%)
Query: 347 TYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRI 406
+Y + L P+TEY R+ P G G P + RT ++P P+ +K +++ I
Sbjct: 578 SYVVEDLKPNTEYAFRLAARSPQ--GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAI 635
Query: 407 AVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLK 466
V W ++ Y + + + P Q ++ L +T +
Sbjct: 636 LVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRIT 695
Query: 467 MILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLD--PNGIITQ 523
+ G ES +++TDEDVP P K I + W+ P +G I
Sbjct: 696 TVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRG 755
Query: 524 YEISYSSIRSFDPAVPVAGPPQTVSNL-----WNST-----HHVFMHLHPGTTYQFFIRA 573
Y++ Y + + GPP+ + W + V +L P T Y + A
Sbjct: 756 YQVHYVRMEGAE----ARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAA 811
Query: 574 STVKGFG----PATAINVTTNISAPTLPDYEGVDASL 606
T+KG G P + + PTL + + SL
Sbjct: 812 YTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSL 848
Score = 48.9 bits (115), Expect = 3e-05
Identities = 67/334 (20%), Positives = 119/334 (35%), Gaps = 37/334 (11%)
Query: 260 VTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIG 319
V +TD+D+ + ++ A ++ P AP + G Y + +
Sbjct: 712 VVRTDEDVPSAPPRKVEAEALNATAIRVLWRSP---APGRQHGQIRGYQVHYVRMEGAEA 768
Query: 320 DGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLL-TRPGEGGTGLPGP 378
GP +K+V M + + ET + +L P+T Y I V T G+G P
Sbjct: 769 RGPPRIKDV---MLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKV 825
Query: 379 PLITRTKCAEP----MRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRG 434
+ P +TP+ +A + + + LGY + F
Sbjct: 826 VVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQ-------------FGR 872
Query: 435 HNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP-GPV 493
+ + L+ P ++ + + ++ + G E ++ ED P G
Sbjct: 873 EDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHP 932
Query: 494 PVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYSSIRSFDPA----VPVAGPPQTV 547
+ G + + L W P+ + NG I +Y ++ + PA +P A P
Sbjct: 933 QILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAE 992
Query: 548 SNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP 581
+ L L P T Y +RA T +G GP
Sbjct: 993 NAL------TLQGLKPDTAYDLQVRAHTRRGPGP 1020
Score = 46.2 bits (108), Expect = 2e-04
Identities = 53/248 (21%), Positives = 96/248 (38%), Gaps = 20/248 (8%)
Query: 391 RTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAP 450
+ P T + E A I + W+S + + ++ ++ + D
Sbjct: 333 KAPGTPMVTENTATSITITWDSGNPDPVSYYVIE-------YKSKSQDGPYQIKEDITTT 385
Query: 451 QHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFL 509
++ + L P + + + N G+ SE + +T E P P + +
Sbjct: 386 RYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIV 445
Query: 510 NWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQF 569
W+EP++PNG+I Y + Y + +P PV + N+ +S L TY
Sbjct: 446 QWEEPVEPNGLIRGYRVYY----TMEPEHPVGNWQK--HNVDDSLLTTVGSLLEDETYTV 499
Query: 570 FIRASTVKGFGP-ATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPIS 628
+ A T G GP + I V T P P +A + T+IT+ P + + I
Sbjct: 500 RVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA---RSETSITLSWSPPRQES--II 554
Query: 629 AYQIVVEE 636
Y+++ E
Sbjct: 555 KYELLFRE 562
Score = 42.0 bits (97), Expect = 0.004
Identities = 104/431 (24%), Positives = 159/431 (36%), Gaps = 68/431 (15%)
Query: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE---PPRPIAPPQ---LLGVGPTY 307
S+ ++++ + +R +S +G G +VR+ +P APPQ + V T
Sbjct: 578 SYVVEDLKPNTEYAFRLAARSPQGLGAFT---PVVRQRTLQSKPSAPPQDVKCVSVRSTA 634
Query: 308 LLIQLNANSI-IGDGPIILKEVEYRMTSGSWTETHAVNA--PTYK---LWHLDPDTEYEI 361
+L+ +G ++ V YR E VN PT L L+ T+Y
Sbjct: 635 ILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQY-- 692
Query: 362 RVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCH 421
R+ E G G P++ RT P P+ ++ + A I V W S R H
Sbjct: 693 RITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPG--RQH 750
Query: 422 TFNVTICYHYFRGHNE-------------SKADCLDMDPKAPQHVVNHLPPYTNVSLKMI 468
HY R + A D + V+ +L P T S+ +
Sbjct: 751 GQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVA 810
Query: 469 LTNPEG-RKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEIS 527
+G S+ ++ T V G P S+Q T E + W EP P G +
Sbjct: 811 AYTMKGDGARSKPKVVVTKGAVLGR-PTLSVQQTP-EGSLLARW-EP--PAGTAEDQVLG 865
Query: 528 YSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA--- 584
Y + + P+A T+ + + +H G TY F + A + G G A
Sbjct: 866 YRLQFGREDSTPLA----TLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVL 921
Query: 585 -INVTTNISAPTLPDYEGVDASLNETATTITVLLR-----PAQAKGAPISAYQIVVEELH 638
I T P + + G A+ TVLLR PA+ GA I Y + V
Sbjct: 922 SIPEDTPRGHPQILEAAG-------NASAGTVLLRWLPPVPAERNGA-IVKYTVAV---- 969
Query: 639 PHRTKREAGAM 649
REAGA+
Sbjct: 970 -----REAGAL 975
Score = 34.3 bits (77), Expect = 0.89
Identities = 38/134 (28%), Positives = 57/134 (42%), Gaps = 21/134 (15%)
Query: 339 ETHAVNAPTYKLWHLDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLK 397
E A NA T L L PDT Y+++V TR G G PP+ RT + + +PK K
Sbjct: 988 EPGAENALT--LQGLKPDTAYDLQVRAHTRRGPGPFS---PPVRYRTFLRDQV-SPKNFK 1041
Query: 398 IAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHL 457
+ I + + WE +N Y + LD+D + + ++ HL
Sbjct: 1042 VKMIMKTSVLLSWEFPD-------NYNSPTPYKI-----QYNGLTLDVDGRTTKKLITHL 1089
Query: 458 PPYTNVSLKMILTN 471
P+T +LTN
Sbjct: 1090 KPHT--FYNFVLTN 1101
Score = 32.3 bits (72), Expect = 3.4
Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 193 DKSPHFLRLGDVEVN-AGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRF 251
++ P F++ ++ +G A+F C ATG D W + G+ + + + I
Sbjct: 30 EEPPRFIKEPKDQIGVSGGVASFVCQATG-DPKPRVTW--NKKGKKVNSQRFETIEFDES 86
Query: 252 A-ASFRLQEV-TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLL 309
A A R+Q + T D+++Y CV Q+ G + ++RE P P + +GP +
Sbjct: 87 AGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPN-IDMGPQLKV 145
Query: 310 IQ 311
++
Sbjct: 146 VE 147
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 513 bits (1321), Expect = e-145
Identities = 349/987 (35%), Positives = 507/987 (51%), Gaps = 126/987 (12%)
Query: 486 DEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQ 545
D+ P VK + TS + L+W+ P + N T Y+I Y+ +
Sbjct: 1011 DQVSPKNFKVKMIMKTS----VLLSWEFPDNYNSP-TPYKIQYNGL-------------- 1051
Query: 546 TVSNLWNSTHHVFMHLHPGTTYQFFI--RASTVKGFGPATAINVTTNI-----SAPTLPD 598
T+ +T + HL P T Y F + R S++ G N+ S PD
Sbjct: 1052 TLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPD 1111
Query: 599 YEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKR---EAGAMECYQVP 655
+G I V L Q+ P+ +Y IV+ L R + G+ E +
Sbjct: 1112 ADGF----------IMVYLPDGQSP-VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLE 1160
Query: 656 VTYQNA-------------MSGGAPYYFA--AELPPGNLPEPAPFTVGDNRTYQGFWNPP 700
Q+ + PY A + LPP F GD + Y GF N
Sbjct: 1161 ELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPP-------TFHPGDQKQYGGFDNRG 1213
Query: 701 LAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI--PDPAKQTDRVVKIAGIS 758
L P Y ++ A+ + T A+ +P + PDP D + +
Sbjct: 1214 LEPGHRYVLFVLAVLQKSEPTFA--------ASPFSDPFQLDNPDPQPIVDGEEGLIWVI 1265
Query: 759 AGILVFILLLLVVI-LIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDP 817
+L + ++ +VI +++ K+K KRKD+ T+ + + AD + H +DP
Sbjct: 1266 GPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN---------ADLAPHHPKDP 1316
Query: 818 LSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHI 877
+ M + NF P L HP I +AD+ +H
Sbjct: 1317 VE---MRRINFQ-----------------TPGMLS------------HPPIPIADMAEHT 1344
Query: 878 NLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDP 937
+K +DS +EYES GQ +W+ + + N+ KNRY N+IAYDHSRVILQP+E
Sbjct: 1345 ERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIM 1404
Query: 938 SSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCY 997
SDYINANY+DGY+ + YIATQGP+ ET DFWRM+W+++SA IVM+T L E R+KC
Sbjct: 1405 GSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCD 1464
Query: 998 KYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPY 1056
+YWP+ TE YG +VT ++ LA + VRTF+L + G +E REV+QF FT WPDHGVP
Sbjct: 1465 QYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPE 1524
Query: 1057 HATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVK 1116
+ T L+F+RRVK NPP AGPIVVHCSAG GRTGC+IVID ML+ + E VD+Y V
Sbjct: 1525 YPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVT 1584
Query: 1117 ALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKD 1176
+RS+R MVQTE+QY FIH+A+LEA CG T +P A + +++ + + ++
Sbjct: 1585 LMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMEL 1644
Query: 1177 EFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAAL 1235
EF+ L + A LP N KNR ++++P + L I G E S+YINA+
Sbjct: 1645 EFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASF 1702
Query: 1236 MDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGML 1293
+D YRQ A+I TQ PL T +DFWR++++ T +VML ++ + C QYWP E
Sbjct: 1703 IDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSA 1762
Query: 1294 RYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY-LMVQQFQYLGWASHREVPGSKRSF 1352
RY V+ M+ + ++ I R +T ++G V+QFQ+ W + VP S F
Sbjct: 1763 RYQYFVVDPMA---EYNMPQYILREFKVTDARDGQSRTVRQFQFTDW-PEQGVPKSGEGF 1818
Query: 1353 LKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTL 1412
+ I QV K +E+ + +G +HC G GR+G+F + IV+E ++ + VVD+F VK L
Sbjct: 1819 IDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKML 1877
Query: 1413 RNSKPNMVEAPEQYRFCYDVALEYLES 1439
R +P MV+ ++Y+FCY ALEYL S
Sbjct: 1878 RTQRPAMVQTEDEYQFCYQAALEYLGS 1904
Score = 72.8 bits (177), Expect = 2e-12
Identities = 100/450 (22%), Positives = 167/450 (37%), Gaps = 70/450 (15%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRNG----EDIPVAQTKNINHRRFAASFRLQEV 260
E+ G N C+A G + K W+Q +D+PV +N+ L+
Sbjct: 242 EIMPGGNVNITCVAVGSPMPYVK-WMQGAEDLTPEDDMPVG--RNV----------LELT 288
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
D Y CV S G + AQ+ V+ P+ P + T + I ++ +
Sbjct: 289 DVKDSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---P 344
Query: 321 GPIILKEVEYRMTS--GSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ +EY+ S G + + Y + L P++EYEI V + G G P
Sbjct: 345 DPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSE 402
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
++TRT P P+ ++ + A + V WE GY + +T
Sbjct: 403 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRV--YYTMEPEHPVG 460
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP 490
++ HN +D V + L T + T+ S+ ++T + VP
Sbjct: 461 NWQKHN--------VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP 512
Query: 491 GPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSS-------IRSFDPAVPVAGP 543
G P+ E I L+W P + I +YE+ + R+FDP
Sbjct: 513 GQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP------- 562
Query: 544 PQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPAT-AINVTTNISAPTLPDYEGV 602
+T +V L P T Y F + A + +G G T + T S P+ P +
Sbjct: 563 ---------TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVK 613
Query: 603 DASLNETATTITVLLRPAQAKGAPISAYQI 632
S+ TA ++ P + + Y +
Sbjct: 614 CVSVRSTAILVSWRPPPPETHNGALVGYSV 643
Score = 46.2 bits (108), Expect = 2e-04
Identities = 53/248 (21%), Positives = 96/248 (38%), Gaps = 20/248 (8%)
Query: 391 RTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAP 450
+ P T + E A I + W+S + + ++ ++ + D
Sbjct: 320 KAPGTPMVTENTATSITITWDSGNPDPVSYYVIE-------YKSKSQDGPYQIKEDITTT 372
Query: 451 QHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFL 509
++ + L P + + + N G+ SE + +T E P P + +
Sbjct: 373 RYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIV 432
Query: 510 NWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQF 569
W+EP++PNG+I Y + Y + +P PV + N+ +S L TY
Sbjct: 433 QWEEPVEPNGLIRGYRVYY----TMEPEHPVGNWQK--HNVDDSLLTTVGSLLEDETYTV 486
Query: 570 FIRASTVKGFGP-ATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPIS 628
+ A T G GP + I V T P P +A + T+IT+ P + + I
Sbjct: 487 RVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA---RSETSITLSWSPPRQES--II 541
Query: 629 AYQIVVEE 636
Y+++ E
Sbjct: 542 KYELLFRE 549
Score = 45.4 bits (106), Expect = 4e-04
Identities = 101/420 (24%), Positives = 157/420 (37%), Gaps = 55/420 (13%)
Query: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE---PPRPIAPPQ---LLGVGPTY 307
S+ ++++ + +R +S +G G +VR+ +P APPQ + V T
Sbjct: 565 SYVVEDLKPNTEYAFRLAARSPQGLGAFT---PVVRQRTLQSKPSAPPQDVKCVSVRSTA 621
Query: 308 LLIQLNANSI-IGDGPIILKEVEYRMTSGSWTETHAVNA--PTYK---LWHLDPDTEYEI 361
+L+ +G ++ V YR E VN PT L L+ T+Y
Sbjct: 622 ILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQY-- 679
Query: 362 RVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCH 421
R+ E G G P++ RT P P+ ++ + A I V W S
Sbjct: 680 RITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQ 739
Query: 422 TFNVTICYHYFRGHNESKADCLD--MDPKAPQHVVNHLPPYTNVSLKMILTNPEG-RKES 478
+ Y G + M A + V+ +L P T S+ + +G S
Sbjct: 740 IRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARS 799
Query: 479 EETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAV 538
+ ++ T V G P S+Q T E + W EP P G + Y + +
Sbjct: 800 KPKVVVTKGAVLGR-PTLSVQQTP-EGSLLARW-EP--PAGTAEDQVLGYRLQFGREDST 854
Query: 539 PVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA----INVTTNISAP 594
P+A T+ + + +H G TY F + A + G G A I T P
Sbjct: 855 PLA----TLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHP 910
Query: 595 TLPDYEGVDASLNETATTITVLLR-----PAQAKGAPISAYQIVVEELHPHRTKREAGAM 649
+ + G A+ TVLLR PA+ GA I Y + V REAGA+
Sbjct: 911 QILEAAG-------NASAGTVLLRWLPPVPAERNGA-IVKYTVAV---------REAGAL 953
Score = 45.4 bits (106), Expect = 4e-04
Identities = 50/242 (20%), Positives = 86/242 (35%), Gaps = 31/242 (12%)
Query: 352 HLDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEP----MRTPKTLKIAEIQARRI 406
+L P+T Y I V T G+G P + P +TP+ +A +
Sbjct: 776 NLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAG 835
Query: 407 AVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLK 466
+ + LGY + F + + L+ P ++ + + +
Sbjct: 836 TAEDQVLGYRLQ-------------FGREDSTPLATLEFPPSEDRYTASGVHKGATYVFR 882
Query: 467 MILTNPEGRKESEETIIQTDEDVP-GPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQ 523
+ + G E ++ ED P G + G + + L W P+ + NG I +
Sbjct: 883 LAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVK 942
Query: 524 YEISYSSIRSFDPA----VPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGF 579
Y ++ + PA +P A P + L L P T Y +RA T +G
Sbjct: 943 YTVAVREAGALGPARETELPAAAEPGAENAL------TLQGLKPDTAYDLQVRAHTRRGP 996
Query: 580 GP 581
GP
Sbjct: 997 GP 998
Score = 34.3 bits (77), Expect = 0.89
Identities = 38/134 (28%), Positives = 57/134 (42%), Gaps = 21/134 (15%)
Query: 339 ETHAVNAPTYKLWHLDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLK 397
E A NA T L L PDT Y+++V TR G G PP+ RT + + +PK K
Sbjct: 966 EPGAENALT--LQGLKPDTAYDLQVRAHTRRGPGPFS---PPVRYRTFLRDQV-SPKNFK 1019
Query: 398 IAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHL 457
+ I + + WE +N Y + LD+D + + ++ HL
Sbjct: 1020 VKMIMKTSVLLSWEFPD-------NYNSPTPYKI-----QYNGLTLDVDGRTTKKLITHL 1067
Query: 458 PPYTNVSLKMILTN 471
P+T +LTN
Sbjct: 1068 KPHT--FYNFVLTN 1079
Score = 32.3 bits (72), Expect = 3.4
Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 193 DKSPHFLRLGDVEVN-AGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRF 251
++ P F++ ++ +G A+F C ATG D W + G+ + + + I
Sbjct: 30 EEPPRFIKEPKDQIGVSGGVASFVCQATG-DPKPRVTW--NKKGKKVNSQRFETIEFDES 86
Query: 252 A-ASFRLQEV-TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLL 309
A A R+Q + T D+++Y CV Q+ G + ++RE P P + +GP +
Sbjct: 87 AGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPN-IDMGPQLKV 145
Query: 310 IQ 311
++
Sbjct: 146 VE 147
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 509 bits (1312), Expect = e-144
Identities = 302/766 (39%), Positives = 431/766 (56%), Gaps = 67/766 (8%)
Query: 682 PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741
P FT+GD++ Y GF N L + Y ++F E+K AT + +
Sbjct: 1200 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 1254
Query: 742 PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKL-AKKRKDAMGNTRQEMTHM 798
DP TD + + +L VFI+ +++ IL+ K+ + + RK ++ N ++ +H
Sbjct: 1255 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH- 1313
Query: 799 VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP 858
H DP+ + R N +S
Sbjct: 1314 --------------HPTDPVEL----------RRLNFQTPGMAS---------------- 1333
Query: 859 YQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYG 918
HP I + +L HI +K +D+ F +EYES GQ +W+ + + N+ KNRY
Sbjct: 1334 ------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYA 1387
Query: 919 NIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQ 978
N+IAYDHSRV+L +E P SDY+NANYIDGY++ + YIATQG + ET DFWRMIW+++
Sbjct: 1388 NVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQR 1447
Query: 979 SACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNE 1037
SA +VM+T L E RVKC +YWP TE +G +VT ++ LA Y VRTF L + G +E
Sbjct: 1448 SATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSE 1507
Query: 1038 IREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVID 1097
REV+QF FT WPDHGVP H T L+F+RRVK NPP AGP+VVHCSAG GRTGC+IVID
Sbjct: 1508 KREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVID 1567
Query: 1098 IMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKA 1157
ML+ + E VDIY V +R++R MVQTE+QYIFIHDA+LEA CG T +P A
Sbjct: 1568 AMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYA 1627
Query: 1158 AYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCL 1217
+ +I++ N + ++ EF+ L S + A LP N KNR ++++P +
Sbjct: 1628 YIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLVNIMPYESTR 1685
Query: 1218 PFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNE 1276
L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR+++++ T +VML +
Sbjct: 1686 VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK 1745
Query: 1277 VDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY-LMVQQ 1333
+ + C QYWP E RY V+ M+ + ++ I R +T ++G V+Q
Sbjct: 1746 LREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQSRTVRQ 1802
Query: 1334 FQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIV 1393
FQ+ W + VP S F+ I QV K +E+ + +G +HC G GR+G+F + IV
Sbjct: 1803 FQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVFITLSIV 1860
Query: 1394 VEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
+E ++ + VVD+F VK LR +P MV+ +QY+F Y ALEYL S
Sbjct: 1861 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1906
Score = 69.7 bits (169), Expect = 2e-11
Identities = 94/444 (21%), Positives = 174/444 (39%), Gaps = 58/444 (13%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260
E+ G + C+A G + K L + +D+P+ + +N R +A+
Sbjct: 246 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 299
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Y CV S G + AQ+ V+ P+P P + T + + ++ +
Sbjct: 300 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 348
Query: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ ++++ + + E V Y + L P ++YE RV+ G G P
Sbjct: 349 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 406
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
P++T+T P P+ ++ + + I V W+ GY + +T + T +
Sbjct: 407 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 464
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489
+ HN + + + +L P S+K++ T+ S + + T V
Sbjct: 465 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515
Query: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
PG P+ E I L+W P + I YE+ Y G Q ++
Sbjct: 516 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 563
Query: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDYEGVDASLNE 608
+ T + L P + Y F + A + +G G +TA I+ T S P+ P + S +
Sbjct: 564 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSS 623
Query: 609 TATTITVLLRPAQAKGAPISAYQI 632
T+ ++ P + + I+ Y I
Sbjct: 624 TSILVSWQPPPVEKQNGIITEYSI 647
Score = 62.4 bits (150), Expect = 3e-09
Identities = 86/385 (22%), Positives = 145/385 (37%), Gaps = 44/385 (11%)
Query: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE-PPRPIAPPQLLGV---GPTYLL 309
S+RLQ + +R +S +G G S A++ R +P APPQ + T +L
Sbjct: 569 SYRLQGLKPNSLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSIL 627
Query: 310 IQLNANSIIGDGPIILK-EVEYRMTSGSWTETHAV-----NAPTYKLWHLDPDTEYEIRV 363
+ + II + ++Y G + H + + Y L L+ TEY R+
Sbjct: 628 VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RI 685
Query: 364 LLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTF 423
+T + G G ++ RT P P+ +++ + + + V W S N
Sbjct: 686 TVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIR 745
Query: 424 NVTICYHYFRGHN-ESKADCLDMD----------PKAPQH--VVNHLPPYTNVSLKMILT 470
+ HY R N E K + D +H +++ L P T+ SL +
Sbjct: 746 GYQV--HYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAY 803
Query: 471 NPEG-RKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYS 529
+G S+ ++ T VPG P + T N + W P+D G + Y + +
Sbjct: 804 TTKGDGARSKPKLVSTTGAVPGK-PRLVINHTQM-NTALIQWHPPVDTFGPLQGYRLKFG 861
Query: 530 SIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTT 589
+ +P T+ H +H G +Y F + A GFG ++
Sbjct: 862 R-KDMEPLT-------TLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI 913
Query: 590 NISAPTLPDYEGVDASLNETATTIT 614
PT G +L+ TT T
Sbjct: 914 PEEVPT-----GFPQNLHSEGTTST 933
Score = 60.5 bits (145), Expect = 1e-08
Identities = 95/420 (22%), Positives = 158/420 (37%), Gaps = 54/420 (12%)
Query: 234 NGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE--- 290
N I ++++I + ++++ ++DQ Y CV + G+ S A L VRE
Sbjct: 171 NNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELRE 230
Query: 291 ----PPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWT--ETHAVN 344
PPR PP + P +N + P + V++ + + T + +
Sbjct: 231 VRRVPPRFSIPPTNHEIMPGG---SVNITCVAVGSP--MPYVKWMLGAEDLTPEDDMPIG 285
Query: 345 APTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQAR 404
+L + Y + T L I + + P T + E A
Sbjct: 286 RNVLELNDVRQSANYTCVAMST--------LGVIEAIAQITVKALPKPPGTPVVTESTAT 337
Query: 405 RIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCL--DMDPKAP-QHVVNHLPPYT 461
I + W+S N +Y H ++ L ++D A ++ V L PY+
Sbjct: 338 SITLTWDS----------GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYS 387
Query: 462 NVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGI 520
+ +++ N GR SE + QT E P P I + WKEP +PNG
Sbjct: 388 DYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ 447
Query: 521 ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580
I Y + Y + DP V N+ +S +L P TY + A T G G
Sbjct: 448 IQGYRVYY----TMDPTQHVNN--WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG 501
Query: 581 PATA-INVTTNISAPTLPDYEGVDASLN---ETATTITVLLRPAQAKGAPISAYQIVVEE 636
P ++ I V T P P LN E + ++LL + I+ Y++V ++
Sbjct: 502 PLSSDIQVITQTGVPGQP--------LNFKAEPESETSILLSWTPPRSDTIANYELVYKD 553
Score = 45.8 bits (107), Expect = 3e-04
Identities = 58/235 (24%), Positives = 82/235 (34%), Gaps = 26/235 (11%)
Query: 353 LDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES 412
L P+T Y + V T G G P + T A P + L I Q + W
Sbjct: 790 LQPETSYSLTV--TAYTTKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWHP 845
Query: 413 LGYNITRCHTFNVTICYHYFRGHNESKA-DCLDMDPKAPQHVVNHLPPYTNVSLKMILTN 471
TF Y G + + L+ K + + ++ N
Sbjct: 846 ------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARN 899
Query: 472 PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYS 529
G E I E+VP P + + L+W+ P+ + NGIIT+Y + Y
Sbjct: 900 KVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR 959
Query: 530 SIRSFDPAVPVAG---PPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP 581
I P +P+ P T L L P TTY +RA T KG GP
Sbjct: 960 DINI--PLLPMEQLIVPADTTMTLTG--------LKPDTTYDVKVRAHTSKGPGP 1004
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 509 bits (1312), Expect = e-144
Identities = 302/766 (39%), Positives = 431/766 (56%), Gaps = 67/766 (8%)
Query: 682 PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741
P FT+GD++ Y GF N L + Y ++F E+K AT + +
Sbjct: 1187 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 1241
Query: 742 PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKL-AKKRKDAMGNTRQEMTHM 798
DP TD + + +L VFI+ +++ IL+ K+ + + RK ++ N ++ +H
Sbjct: 1242 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH- 1300
Query: 799 VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP 858
H DP+ + R N +S
Sbjct: 1301 --------------HPTDPVEL----------RRLNFQTPGMAS---------------- 1320
Query: 859 YQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYG 918
HP I + +L HI +K +D+ F +EYES GQ +W+ + + N+ KNRY
Sbjct: 1321 ------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYA 1374
Query: 919 NIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQ 978
N+IAYDHSRV+L +E P SDY+NANYIDGY++ + YIATQG + ET DFWRMIW+++
Sbjct: 1375 NVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQR 1434
Query: 979 SACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNE 1037
SA +VM+T L E RVKC +YWP TE +G +VT ++ LA Y VRTF L + G +E
Sbjct: 1435 SATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSE 1494
Query: 1038 IREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVID 1097
REV+QF FT WPDHGVP H T L+F+RRVK NPP AGP+VVHCSAG GRTGC+IVID
Sbjct: 1495 KREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVID 1554
Query: 1098 IMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKA 1157
ML+ + E VDIY V +R++R MVQTE+QYIFIHDA+LEA CG T +P A
Sbjct: 1555 AMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYA 1614
Query: 1158 AYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCL 1217
+ +I++ N + ++ EF+ L S + A LP N KNR ++++P +
Sbjct: 1615 YIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLVNIMPYESTR 1672
Query: 1218 PFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNE 1276
L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR+++++ T +VML +
Sbjct: 1673 VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK 1732
Query: 1277 VDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY-LMVQQ 1333
+ + C QYWP E RY V+ M+ + ++ I R +T ++G V+Q
Sbjct: 1733 LREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQSRTVRQ 1789
Query: 1334 FQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIV 1393
FQ+ W + VP S F+ I QV K +E+ + +G +HC G GR+G+F + IV
Sbjct: 1790 FQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVFITLSIV 1847
Query: 1394 VEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
+E ++ + VVD+F VK LR +P MV+ +QY+F Y ALEYL S
Sbjct: 1848 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1893
Score = 69.7 bits (169), Expect = 2e-11
Identities = 94/444 (21%), Positives = 174/444 (39%), Gaps = 58/444 (13%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260
E+ G + C+A G + K L + +D+P+ + +N R +A+
Sbjct: 233 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 286
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Y CV S G + AQ+ V+ P+P P + T + + ++ +
Sbjct: 287 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 335
Query: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ ++++ + + E V Y + L P ++YE RV+ G G P
Sbjct: 336 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 393
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
P++T+T P P+ ++ + + I V W+ GY + +T + T +
Sbjct: 394 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 451
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489
+ HN + + + +L P S+K++ T+ S + + T V
Sbjct: 452 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 502
Query: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
PG P+ E I L+W P + I YE+ Y G Q ++
Sbjct: 503 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 550
Query: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDYEGVDASLNE 608
+ T + L P + Y F + A + +G G +TA I+ T S P+ P + S +
Sbjct: 551 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSS 610
Query: 609 TATTITVLLRPAQAKGAPISAYQI 632
T+ ++ P + + I+ Y I
Sbjct: 611 TSILVSWQPPPVEKQNGIITEYSI 634
Score = 62.4 bits (150), Expect = 3e-09
Identities = 86/385 (22%), Positives = 145/385 (37%), Gaps = 44/385 (11%)
Query: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE-PPRPIAPPQLLGV---GPTYLL 309
S+RLQ + +R +S +G G S A++ R +P APPQ + T +L
Sbjct: 556 SYRLQGLKPNSLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSIL 614
Query: 310 IQLNANSIIGDGPIILK-EVEYRMTSGSWTETHAV-----NAPTYKLWHLDPDTEYEIRV 363
+ + II + ++Y G + H + + Y L L+ TEY R+
Sbjct: 615 VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RI 672
Query: 364 LLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTF 423
+T + G G ++ RT P P+ +++ + + + V W S N
Sbjct: 673 TVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIR 732
Query: 424 NVTICYHYFRGHN-ESKADCLDMD----------PKAPQH--VVNHLPPYTNVSLKMILT 470
+ HY R N E K + D +H +++ L P T+ SL +
Sbjct: 733 GYQV--HYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAY 790
Query: 471 NPEG-RKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYS 529
+G S+ ++ T VPG P + T N + W P+D G + Y + +
Sbjct: 791 TTKGDGARSKPKLVSTTGAVPGK-PRLVINHTQM-NTALIQWHPPVDTFGPLQGYRLKFG 848
Query: 530 SIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTT 589
+ +P T+ H +H G +Y F + A GFG ++
Sbjct: 849 R-KDMEPLT-------TLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI 900
Query: 590 NISAPTLPDYEGVDASLNETATTIT 614
PT G +L+ TT T
Sbjct: 901 PEEVPT-----GFPQNLHSEGTTST 920
Score = 58.9 bits (141), Expect = 3e-08
Identities = 103/447 (23%), Positives = 166/447 (37%), Gaps = 59/447 (13%)
Query: 206 VNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHR---RFAASFRLQEVTK 262
V + AT C A+G W + D T N N R + + ++++ +
Sbjct: 137 VERTRTATMLCAASGNPDPEIT-WFK-----DFLPVDTSNNNGRIKQLRSGALQIEQSEE 190
Query: 263 TDQDLYRCVTQSERGSGVSNFAQLIVRE---PPRPIAPPQLLGVGPTYLLIQLNANSIIG 319
+DQ Y CV + G+ S A L VR PPR PP + P +N +
Sbjct: 191 SDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGG---SVNITCVAV 247
Query: 320 DGPIILKEVEYRMTSGSWT--ETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPG 377
P + V++ + + T + + +L + Y + T L
Sbjct: 248 GSP--MPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMST--------LGV 297
Query: 378 PPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNE 437
I + + P T + E A I + W+S N +Y H
Sbjct: 298 IEAIAQITVKALPKPPGTPVVTESTATSITLTWDS----------GNPEPVSYYIIQHKP 347
Query: 438 SKADCL--DMDPKAP-QHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPV 493
++ L ++D A ++ V L PY++ +++ N GR SE + QT E P
Sbjct: 348 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 407
Query: 494 PVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNS 553
P I + WKEP +PNG I Y + Y + DP V N+ +S
Sbjct: 408 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNN--WMKHNVADS 461
Query: 554 THHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDYEGVDASLN---ET 609
+L P TY + A T G GP ++ I V T P P LN E
Sbjct: 462 QITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP--------LNFKAEP 513
Query: 610 ATTITVLLRPAQAKGAPISAYQIVVEE 636
+ ++LL + I+ Y++V ++
Sbjct: 514 ESETSILLSWTPPRSDTIANYELVYKD 540
Score = 45.8 bits (107), Expect = 3e-04
Identities = 58/235 (24%), Positives = 82/235 (34%), Gaps = 26/235 (11%)
Query: 353 LDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES 412
L P+T Y + V T G G P + T A P + L I Q + W
Sbjct: 777 LQPETSYSLTV--TAYTTKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWHP 832
Query: 413 LGYNITRCHTFNVTICYHYFRGHNESKA-DCLDMDPKAPQHVVNHLPPYTNVSLKMILTN 471
TF Y G + + L+ K + + ++ N
Sbjct: 833 ------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARN 886
Query: 472 PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYS 529
G E I E+VP P + + L+W+ P+ + NGIIT+Y + Y
Sbjct: 887 KVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR 946
Query: 530 SIRSFDPAVPVAG---PPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP 581
I P +P+ P T L L P TTY +RA T KG GP
Sbjct: 947 DINI--PLLPMEQLIVPADTTMTLTG--------LKPDTTYDVKVRAHTSKGPGP 991
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 509 bits (1312), Expect = e-144
Identities = 302/766 (39%), Positives = 431/766 (56%), Gaps = 67/766 (8%)
Query: 682 PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741
P FT+GD++ Y GF N L + Y ++F E+K AT + +
Sbjct: 1191 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 1245
Query: 742 PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKL-AKKRKDAMGNTRQEMTHM 798
DP TD + + +L VFI+ +++ IL+ K+ + + RK ++ N ++ +H
Sbjct: 1246 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH- 1304
Query: 799 VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP 858
H DP+ + R N +S
Sbjct: 1305 --------------HPTDPVEL----------RRLNFQTPGMAS---------------- 1324
Query: 859 YQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYG 918
HP I + +L HI +K +D+ F +EYES GQ +W+ + + N+ KNRY
Sbjct: 1325 ------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYA 1378
Query: 919 NIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQ 978
N+IAYDHSRV+L +E P SDY+NANYIDGY++ + YIATQG + ET DFWRMIW+++
Sbjct: 1379 NVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQR 1438
Query: 979 SACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNE 1037
SA +VM+T L E RVKC +YWP TE +G +VT ++ LA Y VRTF L + G +E
Sbjct: 1439 SATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSE 1498
Query: 1038 IREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVID 1097
REV+QF FT WPDHGVP H T L+F+RRVK NPP AGP+VVHCSAG GRTGC+IVID
Sbjct: 1499 KREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVID 1558
Query: 1098 IMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKA 1157
ML+ + E VDIY V +R++R MVQTE+QYIFIHDA+LEA CG T +P A
Sbjct: 1559 AMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYA 1618
Query: 1158 AYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCL 1217
+ +I++ N + ++ EF+ L S + A LP N KNR ++++P +
Sbjct: 1619 YIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLVNIMPYESTR 1676
Query: 1218 PFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNE 1276
L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR+++++ T +VML +
Sbjct: 1677 VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK 1736
Query: 1277 VDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY-LMVQQ 1333
+ + C QYWP E RY V+ M+ + ++ I R +T ++G V+Q
Sbjct: 1737 LREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQSRTVRQ 1793
Query: 1334 FQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIV 1393
FQ+ W + VP S F+ I QV K +E+ + +G +HC G GR+G+F + IV
Sbjct: 1794 FQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVFITLSIV 1851
Query: 1394 VEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
+E ++ + VVD+F VK LR +P MV+ +QY+F Y ALEYL S
Sbjct: 1852 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1897
Score = 69.7 bits (169), Expect = 2e-11
Identities = 94/444 (21%), Positives = 174/444 (39%), Gaps = 58/444 (13%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260
E+ G + C+A G + K L + +D+P+ + +N R +A+
Sbjct: 246 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 299
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Y CV S G + AQ+ V+ P+P P + T + + ++ +
Sbjct: 300 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 348
Query: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ ++++ + + E V Y + L P ++YE RV+ G G P
Sbjct: 349 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 406
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
P++T+T P P+ ++ + + I V W+ GY + +T + T +
Sbjct: 407 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 464
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489
+ HN + + + +L P S+K++ T+ S + + T V
Sbjct: 465 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515
Query: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
PG P+ E I L+W P + I YE+ Y G Q ++
Sbjct: 516 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 563
Query: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDYEGVDASLNE 608
+ T + L P + Y F + A + +G G +TA I+ T S P+ P + S +
Sbjct: 564 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSS 623
Query: 609 TATTITVLLRPAQAKGAPISAYQI 632
T+ ++ P + + I+ Y I
Sbjct: 624 TSILVSWQPPPVEKQNGIITEYSI 647
Score = 67.0 bits (162), Expect = 1e-10
Identities = 86/376 (22%), Positives = 144/376 (38%), Gaps = 35/376 (9%)
Query: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE-PPRPIAPPQLLGV---GPTYLL 309
S+RLQ + +R +S +G G S A++ R +P APPQ + T +L
Sbjct: 569 SYRLQGLKPNSLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSIL 627
Query: 310 IQLNANSIIGDGPIILK-EVEYRMTSGSWTETHAV-----NAPTYKLWHLDPDTEYEIRV 363
+ + II + ++Y G + H + + Y L L+ TEY R+
Sbjct: 628 VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RI 685
Query: 364 LLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTF 423
+T + G G ++ RT P P+ +++ + + + V W S N
Sbjct: 686 TVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIR 745
Query: 424 NVTICYHYFRGHN-ESKADCLDMD---PKAPQHVVNHLPPYTNVSLKMILTNPEG-RKES 478
+ HY R N E K + D A +++ L P T+ SL + +G S
Sbjct: 746 GYQV--HYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARS 803
Query: 479 EETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAV 538
+ ++ T VPG P + T N + W P+D G + Y + + + +P
Sbjct: 804 KPKLVSTTGAVPGK-PRLVINHTQM-NTALIQWHPPVDTFGPLQGYRLKFGR-KDMEPLT 860
Query: 539 PVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPD 598
T+ H +H G +Y F + A GFG ++ PT
Sbjct: 861 -------TLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT--- 910
Query: 599 YEGVDASLNETATTIT 614
G +L+ TT T
Sbjct: 911 --GFPQNLHSEGTTST 924
Score = 60.5 bits (145), Expect = 1e-08
Identities = 95/420 (22%), Positives = 158/420 (37%), Gaps = 54/420 (12%)
Query: 234 NGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE--- 290
N I ++++I + ++++ ++DQ Y CV + G+ S A L VRE
Sbjct: 171 NNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELRE 230
Query: 291 ----PPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWT--ETHAVN 344
PPR PP + P +N + P + V++ + + T + +
Sbjct: 231 VRRVPPRFSIPPTNHEIMPGG---SVNITCVAVGSP--MPYVKWMLGAEDLTPEDDMPIG 285
Query: 345 APTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQAR 404
+L + Y + T L I + + P T + E A
Sbjct: 286 RNVLELNDVRQSANYTCVAMST--------LGVIEAIAQITVKALPKPPGTPVVTESTAT 337
Query: 405 RIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCL--DMDPKAP-QHVVNHLPPYT 461
I + W+S N +Y H ++ L ++D A ++ V L PY+
Sbjct: 338 SITLTWDS----------GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYS 387
Query: 462 NVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGI 520
+ +++ N GR SE + QT E P P I + WKEP +PNG
Sbjct: 388 DYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ 447
Query: 521 ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580
I Y + Y + DP V N+ +S +L P TY + A T G G
Sbjct: 448 IQGYRVYY----TMDPTQHVNN--WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG 501
Query: 581 PATA-INVTTNISAPTLPDYEGVDASLN---ETATTITVLLRPAQAKGAPISAYQIVVEE 636
P ++ I V T P P LN E + ++LL + I+ Y++V ++
Sbjct: 502 PLSSDIQVITQTGVPGQP--------LNFKAEPESETSILLSWTPPRSDTIANYELVYKD 553
Score = 45.8 bits (107), Expect = 3e-04
Identities = 58/235 (24%), Positives = 82/235 (34%), Gaps = 26/235 (11%)
Query: 353 LDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES 412
L P+T Y + V T G G P + T A P + L I Q + W
Sbjct: 781 LQPETSYSLTV--TAYTTKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWHP 836
Query: 413 LGYNITRCHTFNVTICYHYFRGHNESKA-DCLDMDPKAPQHVVNHLPPYTNVSLKMILTN 471
TF Y G + + L+ K + + ++ N
Sbjct: 837 ------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARN 890
Query: 472 PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYS 529
G E I E+VP P + + L+W+ P+ + NGIIT+Y + Y
Sbjct: 891 KVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR 950
Query: 530 SIRSFDPAVPVAG---PPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP 581
I P +P+ P T L L P TTY +RA T KG GP
Sbjct: 951 DINI--PLLPMEQLIVPADTTMTLTG--------LKPDTTYDVKVRAHTSKGPGP 995
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 509 bits (1312), Expect = e-144
Identities = 302/766 (39%), Positives = 431/766 (56%), Gaps = 67/766 (8%)
Query: 682 PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741
P FT+GD++ Y GF N L + Y ++F E+K AT + +
Sbjct: 789 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 843
Query: 742 PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKL-AKKRKDAMGNTRQEMTHM 798
DP TD + + +L VFI+ +++ IL+ K+ + + RK ++ N ++ +H
Sbjct: 844 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH- 902
Query: 799 VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP 858
H DP+ + R N +S
Sbjct: 903 --------------HPTDPVEL----------RRLNFQTPGMAS---------------- 922
Query: 859 YQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYG 918
HP I + +L HI +K +D+ F +EYES GQ +W+ + + N+ KNRY
Sbjct: 923 ------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYA 976
Query: 919 NIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQ 978
N+IAYDHSRV+L +E P SDY+NANYIDGY++ + YIATQG + ET DFWRMIW+++
Sbjct: 977 NVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQR 1036
Query: 979 SACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNE 1037
SA +VM+T L E RVKC +YWP TE +G +VT ++ LA Y VRTF L + G +E
Sbjct: 1037 SATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSE 1096
Query: 1038 IREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVID 1097
REV+QF FT WPDHGVP H T L+F+RRVK NPP AGP+VVHCSAG GRTGC+IVID
Sbjct: 1097 KREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVID 1156
Query: 1098 IMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKA 1157
ML+ + E VDIY V +R++R MVQTE+QYIFIHDA+LEA CG T +P A
Sbjct: 1157 AMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYA 1216
Query: 1158 AYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCL 1217
+ +I++ N + ++ EF+ L S + A LP N KNR ++++P +
Sbjct: 1217 YIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLVNIMPYESTR 1274
Query: 1218 PFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNE 1276
L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR+++++ T +VML +
Sbjct: 1275 VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK 1334
Query: 1277 VDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY-LMVQQ 1333
+ + C QYWP E RY V+ M+ + ++ I R +T ++G V+Q
Sbjct: 1335 LREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQSRTVRQ 1391
Query: 1334 FQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIV 1393
FQ+ W + VP S F+ I QV K +E+ + +G +HC G GR+G+F + IV
Sbjct: 1392 FQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVFITLSIV 1449
Query: 1394 VEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
+E ++ + VVD+F VK LR +P MV+ +QY+F Y ALEYL S
Sbjct: 1450 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1495
Score = 62.0 bits (149), Expect = 4e-09
Identities = 87/407 (21%), Positives = 158/407 (38%), Gaps = 62/407 (15%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260
E+ G + C+A G + K L + +D+P+ + +N R +A+
Sbjct: 246 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 299
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Y CV S G + AQ+ V+ P+P P + T + + ++ +
Sbjct: 300 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 348
Query: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ ++++ + + E V Y + L P ++YE RV+ G G P
Sbjct: 349 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 406
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
P++T+T P P+ ++ + + I V W+ GY + +T + T +
Sbjct: 407 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 464
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489
+ HN + + + +L P S+K++ T+ S + + T V
Sbjct: 465 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515
Query: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
PG P+ E I L+W P + I YE+ Y G Q ++
Sbjct: 516 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 563
Query: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTL 596
+ T + L P + Y F + A + +G G +TA ISA T+
Sbjct: 564 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTA-----EISARTM 605
Score = 60.5 bits (145), Expect = 1e-08
Identities = 95/420 (22%), Positives = 158/420 (37%), Gaps = 54/420 (12%)
Query: 234 NGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE--- 290
N I ++++I + ++++ ++DQ Y CV + G+ S A L VRE
Sbjct: 171 NNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELRE 230
Query: 291 ----PPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWT--ETHAVN 344
PPR PP + P +N + P + V++ + + T + +
Sbjct: 231 VRRVPPRFSIPPTNHEIMPGG---SVNITCVAVGSP--MPYVKWMLGAEDLTPEDDMPIG 285
Query: 345 APTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQAR 404
+L + Y + T L I + + P T + E A
Sbjct: 286 RNVLELNDVRQSANYTCVAMST--------LGVIEAIAQITVKALPKPPGTPVVTESTAT 337
Query: 405 RIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCL--DMDPKAP-QHVVNHLPPYT 461
I + W+S N +Y H ++ L ++D A ++ V L PY+
Sbjct: 338 SITLTWDS----------GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYS 387
Query: 462 NVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGI 520
+ +++ N GR SE + QT E P P I + WKEP +PNG
Sbjct: 388 DYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ 447
Query: 521 ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580
I Y + Y + DP V N+ +S +L P TY + A T G G
Sbjct: 448 IQGYRVYY----TMDPTQHVNN--WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG 501
Query: 581 PATA-INVTTNISAPTLPDYEGVDASLN---ETATTITVLLRPAQAKGAPISAYQIVVEE 636
P ++ I V T P P LN E + ++LL + I+ Y++V ++
Sbjct: 502 PLSSDIQVITQTGVPGQP--------LNFKAEPESETSILLSWTPPRSDTIANYELVYKD 553
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 507 bits (1306), Expect = e-143
Identities = 303/770 (39%), Positives = 430/770 (55%), Gaps = 71/770 (9%)
Query: 682 PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741
P FT+GD++ Y GF N L + Y ++F E+K AT + +
Sbjct: 786 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 840
Query: 742 PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKLAKK-----RKDAMGNTRQE 794
DP TD + + +L VFI+ +++ IL+ K K+ RK ++ N ++
Sbjct: 841 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEI 900
Query: 795 MTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEG 854
+H H DP+ + R N +S
Sbjct: 901 PSH---------------HPTDPVEL----------RRLNFQTPGMAS------------ 923
Query: 855 TESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAK 914
HP I + +L HI +K +D+ F +EYES GQ +W+ + + N+ K
Sbjct: 924 ----------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPK 973
Query: 915 NRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMI 974
NRY N+IAYDHSRV+L +E P SDY+NANYIDGY++ + YIATQG + ET DFWRMI
Sbjct: 974 NRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMI 1033
Query: 975 WQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERR 1033
W+++SA +VM+T L E RVKC +YWP TE +G +VT ++ LA Y VRTF L +
Sbjct: 1034 WEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKN 1093
Query: 1034 GYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCY 1093
G +E REV+QF FT WPDHGVP H T L+F+RRVK NPP AGP+VVHCSAG GRTGC+
Sbjct: 1094 GSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCF 1153
Query: 1094 IVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVC 1153
IVID ML+ + E VDIY V +R++R MVQTE+QYIFIHDA+LEA CG T +P
Sbjct: 1154 IVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPAR 1213
Query: 1154 EFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPP 1213
A + +I++ N + ++ EF+ L S + A LP N KNR ++++P
Sbjct: 1214 NLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLVNIMPY 1271
Query: 1214 DRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIV 1272
+ L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR+++++ T +V
Sbjct: 1272 ESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVV 1331
Query: 1273 MLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY-L 1329
ML ++ + C QYWP E RY V+ M+ + ++ I R +T ++G
Sbjct: 1332 MLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQSR 1388
Query: 1330 MVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCA 1389
V+QFQ+ W + VP S F+ I QV K +E+ + +G +HC G GR+G+F
Sbjct: 1389 TVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVFIT 1446
Query: 1390 IGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
+ IV+E ++ + VVD+F VK LR +P MV+ +QY+F Y ALEYL S
Sbjct: 1447 LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1496
Score = 62.0 bits (149), Expect = 4e-09
Identities = 87/407 (21%), Positives = 158/407 (38%), Gaps = 62/407 (15%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260
E+ G + C+A G + K L + +D+P+ + +N R +A+
Sbjct: 243 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 296
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Y CV S G + AQ+ V+ P+P P + T + + ++ +
Sbjct: 297 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 345
Query: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ ++++ + + E V Y + L P ++YE RV+ G G P
Sbjct: 346 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 403
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
P++T+T P P+ ++ + + I V W+ GY + +T + T +
Sbjct: 404 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 461
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489
+ HN + + + +L P S+K++ T+ S + + T V
Sbjct: 462 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 512
Query: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
PG P+ E I L+W P + I YE+ Y G Q ++
Sbjct: 513 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 560
Query: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTL 596
+ T + L P + Y F + A + +G G +TA ISA T+
Sbjct: 561 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTA-----EISARTM 602
Score = 58.9 bits (141), Expect = 3e-08
Identities = 92/400 (23%), Positives = 151/400 (37%), Gaps = 54/400 (13%)
Query: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE-------PPRPIAPPQLLGVGPT 306
+ ++++ ++DQ Y CV + G+ S A L VRE PPR PP + P
Sbjct: 188 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPG 247
Query: 307 YLLIQLNANSIIGDGPIILKEVEYRMTSGSWT--ETHAVNAPTYKLWHLDPDTEYEIRVL 364
+N + P + V++ + + T + + +L + Y +
Sbjct: 248 G---SVNITCVAVGSP--MPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAM 302
Query: 365 LTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFN 424
T L I + + P T + E A I + W+S N
Sbjct: 303 ST--------LGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS----------GN 344
Query: 425 VTICYHYFRGHNESKADCL--DMDPKAP-QHVVNHLPPYTNVSLKMILTNPEGR-KESEE 480
+Y H ++ L ++D A ++ V L PY++ +++ N GR SE
Sbjct: 345 PEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEP 404
Query: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV 540
+ QT E P P I + WKEP +PNG I Y + Y + DP V
Sbjct: 405 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHV 460
Query: 541 AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDY 599
N+ +S +L P TY + A T G GP ++ I V T P P
Sbjct: 461 NN--WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP-- 516
Query: 600 EGVDASLN---ETATTITVLLRPAQAKGAPISAYQIVVEE 636
LN E + ++LL + I+ Y++V ++
Sbjct: 517 ------LNFKAEPESETSILLSWTPPRSDTIANYELVYKD 550
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 506 bits (1303), Expect = e-143
Identities = 300/778 (38%), Positives = 443/778 (56%), Gaps = 69/778 (8%)
Query: 669 YFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRI 728
Y AA+L LPE FT+GD + Y+GF+N PL+P Y + A + K
Sbjct: 1186 YVAAQLDV--LPET--FTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYA--- 1238
Query: 729 ATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAM 788
+ ++E V PA+Q + ++ ++ +L IL++L+VI I+ L K+++
Sbjct: 1239 --SSPYSDEIVVQVTPAQQQEEP-EMLWVTGPVLAVILIILIVIAIL----LFKRKRTHS 1291
Query: 789 GNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVP 848
+++ E + + D H+ DP+ + ++
Sbjct: 1292 PSSKDEQSIGLK-------DSLLAHSSDPVEMRRLN------------------------ 1320
Query: 849 RYLCEGTESPYQTGQL--HPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVA 906
YQT + HP I + DL +I +K +D F +EYES GQ +W+ +
Sbjct: 1321 ----------YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENS 1370
Query: 907 KKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHET 966
+ N+ KNRY N+IAYDHSRVIL ++ P SDYINANYIDGY++ + YIATQGP+ ET
Sbjct: 1371 NLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET 1430
Query: 967 VYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVV 1025
+ DFWRM+W++++A +VM+T L E RVKC +YWP TE G +VT ++ LA Y V
Sbjct: 1431 MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTV 1490
Query: 1026 RTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSA 1085
RTF L + G +E RE++QF F WPDHGVP + T +L+F+RRVK NP AGP+VVHCSA
Sbjct: 1491 RTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSA 1550
Query: 1086 GAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLC 1145
G GRTGC+IVID ML+ + E VDIY V +RS+R MVQTE+QY+FIH+A+LEA C
Sbjct: 1551 GVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATC 1610
Query: 1146 GETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKN 1205
G T +P A + ++ + + ++ EF+ L S + A LP N KN
Sbjct: 1611 GHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLAS--SKAHTSRFISANLPCNKFKN 1668
Query: 1206 RFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVY 1264
R ++++P + L I G E S+YINA+ +D YRQ A+I TQ PL + +DFWR+++
Sbjct: 1669 RLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLW 1728
Query: 1265 DYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLT 1322
++ T IVML ++ + C QYWP E RY V+ M+ + ++ I R +T
Sbjct: 1729 EHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVT 1785
Query: 1323 RPQEGY-LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGG 1381
++G ++QFQ+ W + VP + F+ I QV K +E+ + +G +HC G
Sbjct: 1786 DARDGQSRTIRQFQFTDW-PEQGVPKTGEGFIDFIGQVHKTKEQFGQ-DGPITVHCSAGV 1843
Query: 1382 GRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
GR+G+F + IV+E ++ + VVD+F VKTLR +P MV+ +QY+ CY ALEYL S
Sbjct: 1844 GRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGS 1901
Score = 72.0 bits (175), Expect = 4e-12
Identities = 106/447 (23%), Positives = 172/447 (38%), Gaps = 57/447 (12%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWL----QRRNGEDIPVAQTKNINHRRFAASFRLQEV 260
EV G + C+A G + K W+ + +++PV +N+ L V
Sbjct: 242 EVMPGGSVNLTCVAVGAPMPYVK-WMMGAEELTKEDEMPVG--RNV--------LELSNV 290
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
++ Y CV S G + AQ+ V+ P+P P L+ T + L +S +
Sbjct: 291 VRSAN--YTCVAISSLGM-IEATAQVTVKALPKP--PIDLVVTETTATSVTLTWDSGNSE 345
Query: 321 GPIILKEVEYRM--TSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ ++YR T G + E V Y + L P +EY RVL G G P
Sbjct: 346 -PVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV--NSIGRGPPSE 402
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
+ RT P P+ ++ + A + V WE GY + +T + +
Sbjct: 403 AVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV--YYTPDSRRPPN 460
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETI-IQTDEDV 489
+ HN + A L V L P SL+++ G TI ++T + V
Sbjct: 461 AWHKHN-TDAGLLT--------TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGV 511
Query: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
P P + +I L+W P P I YE+ Y + D V P
Sbjct: 512 PAQ-PADFQAEVESDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKVTFDP----- 563
Query: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPAT-AINVTTNISAPTLPDYEGVDASLNE 608
++ + L P T Y+F + A + G G T I T S P+ P + + S+
Sbjct: 564 ---TSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGS 620
Query: 609 TATTITVLLRPAQAKGAPISAYQIVVE 635
T ++ + PA ++ I+ Y + E
Sbjct: 621 TTVRVSWVPPPADSRNGVITQYSVAYE 647
Score = 58.5 bits (140), Expect = 4e-08
Identities = 66/257 (25%), Positives = 96/257 (37%), Gaps = 46/257 (17%)
Query: 353 LDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDW- 410
L P+T Y + V T G+G P I T A P R T+ I+ + W
Sbjct: 787 LTPETTYSVTVAAYTTKGDGARS---KPKIVTTTGAVPGRP--TMMISTTAMNTALLQWH 841
Query: 411 -------ESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNV 463
E LGY + C +E++ + +D V L T
Sbjct: 842 PPKELPGELLGYRLQYCRA-------------DEARPNTIDFGKDDQHFTVTGLHKGTTY 888
Query: 464 SLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIF-LNWKEPL--DPNGI 520
++ N G E E I+T ED+P P ++L T L W P+ + NG
Sbjct: 889 IFRLAAKNRAGLGEEFEKEIRTPEDLPSGFP-QNLHVTGLTTSTTELAWDPPVLAERNGR 947
Query: 521 ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580
I Y + + I S Q + N+ T L P TTY +RA T KG G
Sbjct: 948 IISYTVVFRDINS----------QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSG 997
Query: 581 PATAINVTTNISAPTLP 597
P ++ +I + T+P
Sbjct: 998 P-----LSPSIQSRTMP 1009
Score = 50.1 bits (118), Expect = 2e-05
Identities = 66/288 (22%), Positives = 113/288 (39%), Gaps = 21/288 (7%)
Query: 355 PDTEYEIRVL-LTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESL 413
P Y +RVL T G+G P P + +T+ P + P + RI + W L
Sbjct: 480 PGITYSLRVLAFTAVGDGP---PSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLSW--L 533
Query: 414 GYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPE 473
R + + Y+ +E + + DP + + + L P T ++ +
Sbjct: 534 LPPQERIIMYELV----YWAAEDEDQQHKVTFDPTS-SYTLEDLKPDTLYRFQLAARSDM 588
Query: 474 GRKESEETI-IQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYSS 530
G TI +T + P P K + + + ++W P NG+ITQY ++Y +
Sbjct: 589 GVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEA 648
Query: 531 IRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP-ATAINVTT 589
+ D V + W+ + L T Y+ ++RA T G GP ++ + V T
Sbjct: 649 VDGEDRGRHVVDGISREHSSWD-----LVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRT 703
Query: 590 NISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEEL 637
+ P+ P + LN TA + L + I YQ+ L
Sbjct: 704 DEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRL 751
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 506 bits (1303), Expect = e-143
Identities = 300/778 (38%), Positives = 443/778 (56%), Gaps = 69/778 (8%)
Query: 669 YFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRI 728
Y AA+L LPE FT+GD + Y+GF+N PL+P Y + A + K
Sbjct: 1177 YVAAQLDV--LPET--FTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYA--- 1229
Query: 729 ATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAM 788
+ ++E V PA+Q + ++ ++ +L IL++L+VI I+ L K+++
Sbjct: 1230 --SSPYSDEIVVQVTPAQQQEEP-EMLWVTGPVLAVILIILIVIAIL----LFKRKRTHS 1282
Query: 789 GNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVP 848
+++ E + + D H+ DP+ + ++
Sbjct: 1283 PSSKDEQSIGLK-------DSLLAHSSDPVEMRRLN------------------------ 1311
Query: 849 RYLCEGTESPYQTGQL--HPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVA 906
YQT + HP I + DL +I +K +D F +EYES GQ +W+ +
Sbjct: 1312 ----------YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENS 1361
Query: 907 KKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHET 966
+ N+ KNRY N+IAYDHSRVIL ++ P SDYINANYIDGY++ + YIATQGP+ ET
Sbjct: 1362 NLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET 1421
Query: 967 VYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVV 1025
+ DFWRM+W++++A +VM+T L E RVKC +YWP TE G +VT ++ LA Y V
Sbjct: 1422 MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTV 1481
Query: 1026 RTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSA 1085
RTF L + G +E RE++QF F WPDHGVP + T +L+F+RRVK NP AGP+VVHCSA
Sbjct: 1482 RTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSA 1541
Query: 1086 GAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLC 1145
G GRTGC+IVID ML+ + E VDIY V +RS+R MVQTE+QY+FIH+A+LEA C
Sbjct: 1542 GVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATC 1601
Query: 1146 GETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKN 1205
G T +P A + ++ + + ++ EF+ L S + A LP N KN
Sbjct: 1602 GHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLAS--SKAHTSRFISANLPCNKFKN 1659
Query: 1206 RFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVY 1264
R ++++P + L I G E S+YINA+ +D YRQ A+I TQ PL + +DFWR+++
Sbjct: 1660 RLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLW 1719
Query: 1265 DYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLT 1322
++ T IVML ++ + C QYWP E RY V+ M+ + ++ I R +T
Sbjct: 1720 EHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVT 1776
Query: 1323 RPQEGY-LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGG 1381
++G ++QFQ+ W + VP + F+ I QV K +E+ + +G +HC G
Sbjct: 1777 DARDGQSRTIRQFQFTDW-PEQGVPKTGEGFIDFIGQVHKTKEQFGQ-DGPITVHCSAGV 1834
Query: 1382 GRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
GR+G+F + IV+E ++ + VVD+F VKTLR +P MV+ +QY+ CY ALEYL S
Sbjct: 1835 GRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGS 1892
Score = 72.0 bits (175), Expect = 4e-12
Identities = 106/447 (23%), Positives = 172/447 (38%), Gaps = 57/447 (12%)
Query: 205 EVNAGQNATFQCIATGRDAVHNKLWL----QRRNGEDIPVAQTKNINHRRFAASFRLQEV 260
EV G + C+A G + K W+ + +++PV +N+ L V
Sbjct: 242 EVMPGGSVNLTCVAVGAPMPYVK-WMMGAEELTKEDEMPVG--RNV--------LELSNV 290
Query: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
++ Y CV S G + AQ+ V+ P+P P L+ T + L +S +
Sbjct: 291 VRSAN--YTCVAISSLGM-IEATAQVTVKALPKP--PIDLVVTETTATSVTLTWDSGNSE 345
Query: 321 GPIILKEVEYRM--TSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
P+ ++YR T G + E V Y + L P +EY RVL G G P
Sbjct: 346 -PVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV--NSIGRGPPSE 402
Query: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
+ RT P P+ ++ + A + V WE GY + +T + +
Sbjct: 403 AVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV--YYTPDSRRPPN 460
Query: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETI-IQTDEDV 489
+ HN + A L V L P SL+++ G TI ++T + V
Sbjct: 461 AWHKHN-TDAGLLT--------TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGV 511
Query: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
P P + +I L+W P P I YE+ Y + D V P
Sbjct: 512 PAQ-PADFQAEVESDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKVTFDP----- 563
Query: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPAT-AINVTTNISAPTLPDYEGVDASLNE 608
++ + L P T Y+F + A + G G T I T S P+ P + + S+
Sbjct: 564 ---TSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGS 620
Query: 609 TATTITVLLRPAQAKGAPISAYQIVVE 635
T ++ + PA ++ I+ Y + E
Sbjct: 621 TTVRVSWVPPPADSRNGVITQYSVAYE 647
Score = 58.5 bits (140), Expect = 4e-08
Identities = 66/257 (25%), Positives = 96/257 (37%), Gaps = 46/257 (17%)
Query: 353 LDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDW- 410
L P+T Y + V T G+G P I T A P R T+ I+ + W
Sbjct: 778 LTPETTYSVTVAAYTTKGDGARS---KPKIVTTTGAVPGRP--TMMISTTAMNTALLQWH 832
Query: 411 -------ESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNV 463
E LGY + C +E++ + +D V L T
Sbjct: 833 PPKELPGELLGYRLQYCRA-------------DEARPNTIDFGKDDQHFTVTGLHKGTTY 879
Query: 464 SLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIF-LNWKEPL--DPNGI 520
++ N G E E I+T ED+P P ++L T L W P+ + NG
Sbjct: 880 IFRLAAKNRAGLGEEFEKEIRTPEDLPSGFP-QNLHVTGLTTSTTELAWDPPVLAERNGR 938
Query: 521 ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580
I Y + + I S Q + N+ T L P TTY +RA T KG G
Sbjct: 939 IISYTVVFRDINS----------QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSG 988
Query: 581 PATAINVTTNISAPTLP 597
P ++ +I + T+P
Sbjct: 989 P-----LSPSIQSRTMP 1000
Score = 50.1 bits (118), Expect = 2e-05
Identities = 66/288 (22%), Positives = 113/288 (39%), Gaps = 21/288 (7%)
Query: 355 PDTEYEIRVL-LTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESL 413
P Y +RVL T G+G P P + +T+ P + P + RI + W L
Sbjct: 480 PGITYSLRVLAFTAVGDGP---PSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLSW--L 533
Query: 414 GYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPE 473
R + + Y+ +E + + DP + + + L P T ++ +
Sbjct: 534 LPPQERIIMYELV----YWAAEDEDQQHKVTFDPTS-SYTLEDLKPDTLYRFQLAARSDM 588
Query: 474 GRKESEETI-IQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYSS 530
G TI +T + P P K + + + ++W P NG+ITQY ++Y +
Sbjct: 589 GVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEA 648
Query: 531 IRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP-ATAINVTT 589
+ D V + W+ + L T Y+ ++RA T G GP ++ + V T
Sbjct: 649 VDGEDRGRHVVDGISREHSSWD-----LVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRT 703
Query: 590 NISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEEL 637
+ P+ P + LN TA + L + I YQ+ L
Sbjct: 704 DEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRL 751
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 441 bits (1135), Expect = e-123
Identities = 236/588 (40%), Positives = 356/588 (60%), Gaps = 16/588 (2%)
Query: 861 TGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGN 919
T + +P + V L + IN D+ F+EE+ + A+ + A K++N+ KNRY N
Sbjct: 205 TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 264
Query: 920 IIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQS 979
I+ YDHSRV L PVE P SDYINA++I+GYQ + +IA QGP ETV DFWRMIW++ +
Sbjct: 265 ILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNT 324
Query: 980 ACIVMVTNLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEI 1038
A IVMVTNL E KC +YWPD YG+ +V+ ++ L +Y VR F +++ G
Sbjct: 325 ATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTN 384
Query: 1039 RE----VKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYI 1094
R+ + QFHFT WPD GVP+ G+L F+++VK NP AG IVVHCSAG GRTG ++
Sbjct: 385 RKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFV 444
Query: 1095 VIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCE 1154
VID MLDM E VD+Y V +R++R MVQT+ QY+FI+ A+LE L G+T + V
Sbjct: 445 VIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTS 504
Query: 1155 FKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPD 1214
+ + T+++ L++EF+ L S+ ++Q + LP N KNR + ++P +
Sbjct: 505 LETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVLQIIPYE 562
Query: 1215 RCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVM 1273
+ G E+++Y+NA+ +D YRQ ++I +Q PL +T++DFWR+++++ SIVM
Sbjct: 563 FNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVM 622
Query: 1274 LNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMV 1331
L E++ + C QYWP +G++ YG I VE + +C+ + TR + +
Sbjct: 623 LTELEERGQEKCAQYWPSDGLVSYGDITVE-LKKEEECESYTVRDLLVTNTRENKS-RQI 680
Query: 1332 QQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIG 1391
+QF + GW +P + + +I V+K Q+ + G +HC G GR+G FCA+
Sbjct: 681 RQFHFHGW-PEVGIPSDGKGMISIIAAVQKQQQ--QSGNHPITVHCSAGAGRTGTFCALS 737
Query: 1392 IVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
V+E VK + ++DVF VK+LR +P+MV+ EQY FCY V EY+++
Sbjct: 738 TVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA 785
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 441 bits (1135), Expect = e-123
Identities = 236/588 (40%), Positives = 356/588 (60%), Gaps = 16/588 (2%)
Query: 861 TGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGN 919
T + +P + V L + IN D+ F+EE+ + A+ + A K++N+ KNRY N
Sbjct: 214 TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 273
Query: 920 IIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQS 979
I+ YDHSRV L PVE P SDYINA++I+GYQ + +IA QGP ETV DFWRMIW++ +
Sbjct: 274 ILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNT 333
Query: 980 ACIVMVTNLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEI 1038
A IVMVTNL E KC +YWPD YG+ +V+ ++ L +Y VR F +++ G
Sbjct: 334 ATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTN 393
Query: 1039 RE----VKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYI 1094
R+ + QFHFT WPD GVP+ G+L F+++VK NP AG IVVHCSAG GRTG ++
Sbjct: 394 RKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFV 453
Query: 1095 VIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCE 1154
VID MLDM E VD+Y V +R++R MVQT+ QY+FI+ A+LE L G+T + V
Sbjct: 454 VIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTS 513
Query: 1155 FKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPD 1214
+ + T+++ L++EF+ L S+ ++Q + LP N KNR + ++P +
Sbjct: 514 LETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVLQIIPYE 571
Query: 1215 RCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVM 1273
+ G E+++Y+NA+ +D YRQ ++I +Q PL +T++DFWR+++++ SIVM
Sbjct: 572 FNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVM 631
Query: 1274 LNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMV 1331
L E++ + C QYWP +G++ YG I VE + +C+ + TR + +
Sbjct: 632 LTELEERGQEKCAQYWPSDGLVSYGDITVE-LKKEEECESYTVRDLLVTNTRENKS-RQI 689
Query: 1332 QQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIG 1391
+QF + GW +P + + +I V+K Q+ + G +HC G GR+G FCA+
Sbjct: 690 RQFHFHGW-PEVGIPSDGKGMISIIAAVQKQQQ--QSGNHPITVHCSAGAGRTGTFCALS 746
Query: 1392 IVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
V+E VK + ++DVF VK+LR +P+MV+ EQY FCY V EY+++
Sbjct: 747 TVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA 794
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 441 bits (1135), Expect = e-123
Identities = 236/588 (40%), Positives = 356/588 (60%), Gaps = 16/588 (2%)
Query: 861 TGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGN 919
T + +P + V L + IN D+ F+EE+ + A+ + A K++N+ KNRY N
Sbjct: 205 TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 264
Query: 920 IIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQS 979
I+ YDHSRV L PVE P SDYINA++I+GYQ + +IA QGP ETV DFWRMIW++ +
Sbjct: 265 ILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNT 324
Query: 980 ACIVMVTNLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEI 1038
A IVMVTNL E KC +YWPD YG+ +V+ ++ L +Y VR F +++ G
Sbjct: 325 ATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTN 384
Query: 1039 RE----VKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYI 1094
R+ + QFHFT WPD GVP+ G+L F+++VK NP AG IVVHCSAG GRTG ++
Sbjct: 385 RKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFV 444
Query: 1095 VIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCE 1154
VID MLDM E VD+Y V +R++R MVQT+ QY+FI+ A+LE L G+T + V
Sbjct: 445 VIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTS 504
Query: 1155 FKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPD 1214
+ + T+++ L++EF+ L S+ ++Q + LP N KNR + ++P +
Sbjct: 505 LETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVLQIIPYE 562
Query: 1215 RCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVM 1273
+ G E+++Y+NA+ +D YRQ ++I +Q PL +T++DFWR+++++ SIVM
Sbjct: 563 FNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVM 622
Query: 1274 LNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMV 1331
L E++ + C QYWP +G++ YG I VE + +C+ + TR + +
Sbjct: 623 LTELEERGQEKCAQYWPSDGLVSYGDITVE-LKKEEECESYTVRDLLVTNTRENKS-RQI 680
Query: 1332 QQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIG 1391
+QF + GW +P + + +I V+K Q+ + G +HC G GR+G FCA+
Sbjct: 681 RQFHFHGW-PEVGIPSDGKGMISIIAAVQKQQQ--QSGNHPITVHCSAGAGRTGTFCALS 737
Query: 1392 IVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
V+E VK + ++DVF VK+LR +P+MV+ EQY FCY V EY+++
Sbjct: 738 TVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA 785
>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
precursor [Homo sapiens]
Length = 700
Score = 426 bits (1096), Expect = e-119
Identities = 238/583 (40%), Positives = 346/583 (59%), Gaps = 18/583 (3%)
Query: 868 IRVADLLQHINLMKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGNIIAYDHS 926
I V L + I + D F+EE+ S G ++++A K++NR KNRY NI+ DHS
Sbjct: 115 IPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHS 174
Query: 927 RVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVT 986
RVIL ++ P SDYINA+YIDGY+ + +IA QGP ETV DFWRM+W+++SA IVM+T
Sbjct: 175 RVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLT 234
Query: 987 NLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLERR---GYNEIREVK 1042
NL E KC++YWPD YG+ +V + L +Y +R F ++ + G R V
Sbjct: 235 NLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVS 294
Query: 1043 QFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDM 1102
Q HFT WPD GVP+ G+L F+++VK NP AGPIVVHCSAG GRTG +IVID M+ M
Sbjct: 295 QLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAM 354
Query: 1103 AEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDM 1162
E VD++ V +R++R MVQT+ QY FI+ A+LE L G+T + V + M
Sbjct: 355 MHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTM 414
Query: 1163 IRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLIT 1222
+ + L++EF+ L +V R+ E+ LP N K R + ++P D L
Sbjct: 415 HGTTTHFDKIGLEEEFRKLTNV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSM 472
Query: 1223 IDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQ 1281
G E ++YINA+ +D YRQ FI TQ PL +TV+DFWR+++++ +IVML EV +
Sbjct: 473 KRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQERE 532
Query: 1282 --GCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQ----EGYLMVQQFQ 1335
C QYWP EG + +G I +E + ++ + R F + L +PQ E +V+QF
Sbjct: 533 QDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDF-LVTLNQPQARQEEQVRVVRQFH 591
Query: 1336 YLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVE 1395
+ GW +P + + LI V+K Q+ + G +HC G GR+G F A+ ++E
Sbjct: 592 FHGW-PEIGIPAEGKGMIDLIAAVQKQQQ--QTGNHPITVHCSAGAGRTGTFIALSNILE 648
Query: 1396 MVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1438
VK + ++DVF AVK+LR +P+MV+ EQY FCY V ++++
Sbjct: 649 RVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID 691
>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
[Homo sapiens]
Length = 642
Score = 426 bits (1096), Expect = e-119
Identities = 238/583 (40%), Positives = 346/583 (59%), Gaps = 18/583 (3%)
Query: 868 IRVADLLQHINLMKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGNIIAYDHS 926
I V L + I + D F+EE+ S G ++++A K++NR KNRY NI+ DHS
Sbjct: 57 IPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHS 116
Query: 927 RVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVT 986
RVIL ++ P SDYINA+YIDGY+ + +IA QGP ETV DFWRM+W+++SA IVM+T
Sbjct: 117 RVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLT 176
Query: 987 NLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLERR---GYNEIREVK 1042
NL E KC++YWPD YG+ +V + L +Y +R F ++ + G R V
Sbjct: 177 NLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVS 236
Query: 1043 QFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDM 1102
Q HFT WPD GVP+ G+L F+++VK NP AGPIVVHCSAG GRTG +IVID M+ M
Sbjct: 237 QLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAM 296
Query: 1103 AEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDM 1162
E VD++ V +R++R MVQT+ QY FI+ A+LE L G+T + V + M
Sbjct: 297 MHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTM 356
Query: 1163 IRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLIT 1222
+ + L++EF+ L +V R+ E+ LP N K R + ++P D L
Sbjct: 357 HGTTTHFDKIGLEEEFRKLTNV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSM 414
Query: 1223 IDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQ 1281
G E ++YINA+ +D YRQ FI TQ PL +TV+DFWR+++++ +IVML EV +
Sbjct: 415 KRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQERE 474
Query: 1282 --GCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQ----EGYLMVQQFQ 1335
C QYWP EG + +G I +E + ++ + R F + L +PQ E +V+QF
Sbjct: 475 QDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDF-LVTLNQPQARQEEQVRVVRQFH 533
Query: 1336 YLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVE 1395
+ GW +P + + LI V+K Q+ + G +HC G GR+G F A+ ++E
Sbjct: 534 FHGW-PEIGIPAEGKGMIDLIAAVQKQQQ--QTGNHPITVHCSAGAGRTGTFIALSNILE 590
Query: 1396 MVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1438
VK + ++DVF AVK+LR +P+MV+ EQY FCY V ++++
Sbjct: 591 RVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID 633
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 375 bits (964), Expect = e-103
Identities = 220/581 (37%), Positives = 330/581 (56%), Gaps = 35/581 (6%)
Query: 885 SYGFKEEYES----FFEGQSASWDV------AKKDQNRAKNRYGNIIAYDHSRVILQPV- 933
S GF EE+E+ + E QS + D+ + N+ KNRY NI+AYDHSRV L +
Sbjct: 1714 SSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLA 1773
Query: 934 -EDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVG 992
+D +DYINANY+DGY RP YIA QGP+ T DFWRMIW+ IVM+TNLVE G
Sbjct: 1774 EKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKG 1833
Query: 993 RVKCYKYWP-DDTEVYGDFKVTCVEMEPLAEYVVRTFTLE--------RRGYNEIREVKQ 1043
R KC +YWP D +E YG+F VT ++ LA Y VR FTL ++G R V Q
Sbjct: 1834 RRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQ 1893
Query: 1044 FHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMA 1103
+H+T WPD GVP ++ +L+F+R+ + + GP+VVHCSAG GRTG YIV+D ML
Sbjct: 1894 YHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQI 1953
Query: 1104 EREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMI 1163
+ EG V+I+ +K +RS+R +VQTEEQY+FIHD ++EA L ET + + AY + +
Sbjct: 1954 QHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV-LDSHIHAYVNAL 2012
Query: 1164 RIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITI 1223
I + L+ +FQ L+ +Q D S A N +KNR ++P +R + ++
Sbjct: 2013 LIPGPAGKTKLEKQFQLLSQ--SNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSL 2070
Query: 1224 DGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNE-VDLSQG 1282
GE ++YINA+ + Y Q FI+TQ+PL +T+KDFWR+++D+ +VM+ + ++++
Sbjct: 2071 SGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAED 2130
Query: 1283 CPQYWP-EEGMLRYGPIQVECMSCSMDC--DVINRIFRICNLTRPQEGYLM-VQQFQYLG 1338
YWP ++ + +V M+ C + I + L Q+ Y++ V+ FQ
Sbjct: 2131 EFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPK 2190
Query: 1339 WASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVK 1398
W P K + +EE +G I+H +GG +G FCA+ ++ ++
Sbjct: 2191 W------PNPDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLE 2244
Query: 1399 RQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
++N VDV+ K + +P + EQY+F Y V L + +
Sbjct: 2245 KENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST 2285
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 360 bits (925), Expect = 4e-99
Identities = 220/608 (36%), Positives = 332/608 (54%), Gaps = 56/608 (9%)
Query: 867 AIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDV------AKKDQNRAKNRYGNI 920
AI V ++HI + +++ +GF E++E E Q + D+ + +N+ KNRY NI
Sbjct: 827 AIPVKQFVKHIGELYSNNQHGFSEDFE---EVQRCTADMNITAEHSNHPENKHKNRYINI 883
Query: 921 IAYDHSRVILQPV--EDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQ 978
+AYDHSRV L+P+ +D SDYINANY+DGY + YIATQGP+ T DFWRMIW++
Sbjct: 884 LAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQN 943
Query: 979 SACIVMVTNLVEVGRVKCYKYWP-DDTEVYGDFKVTCVEMEPLAEYVVRTFTLER----- 1032
+ IVM+TNLVE GR KC +YWP +++E YG+ VT + A Y VR F++
Sbjct: 944 TGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKK 1003
Query: 1033 ------RGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAG 1086
+G R V Q+H+T WPD GVP +A +L+F+RR + P GP++VHCSAG
Sbjct: 1004 GQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAG 1063
Query: 1087 AGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCG 1146
GRTG YIVID ML + + V++ +K +R++R +VQTEEQYIFIHDA+LEA L
Sbjct: 1064 VGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGK 1123
Query: 1147 ETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNR 1206
ET + + +Y + I I + L+ +F+ + + +C A N +KNR
Sbjct: 1124 ETEVSSNQLH-SYVNSILIPGVGGKTRLEKQFKLVTQCNAKY--VECFSAQKECNKEKNR 1180
Query: 1207 FMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYD 1265
++P +R L + G + ++YINA+ + Y + FI+TQ+PLP+T KDFWR+++D
Sbjct: 1181 NSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWD 1240
Query: 1266 YGCTSIVML-NEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRIC----- 1319
+ IVML + L++ YWP + E M+C + R+C
Sbjct: 1241 HNAQIIVMLPDNQSLAEDEFVYWPS---------REESMNCEAFTVTLISKDRLCLSNEE 1291
Query: 1320 -------NLTRPQEGYLM-VQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEG 1371
L Q+ Y++ V+ FQ W + S + +I +EE +G
Sbjct: 1292 QIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISSTFELINVI------KEEALTRDG 1345
Query: 1372 RTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYD 1431
TI+H G +GM CA+ + + ++ +N VDVF K + +P + EQY+F Y
Sbjct: 1346 PTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYK 1405
Query: 1432 VALEYLES 1439
L + +
Sbjct: 1406 AMLSLVST 1413
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
precursor [Homo sapiens]
Length = 1256
Score = 337 bits (864), Expect = 5e-92
Identities = 210/561 (37%), Positives = 293/561 (52%), Gaps = 42/561 (7%)
Query: 906 AKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHE 965
A+K N+ KNRY +I+ YD++RV L + D S+YINA+YIDG++ P YIA QGP E
Sbjct: 622 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681
Query: 966 TVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP---DDTEVYGDFKVTCVEMEPLAE 1022
TV DFWRMIW++++ IVMVT E R KC +YWP + T +GD V + + +
Sbjct: 682 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741
Query: 1023 YVVRTFTLERRGYNEI-REVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVV 1081
Y+++ + + REV FT WPDHGVP LL RRV + +GPIVV
Sbjct: 742 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVV 801
Query: 1082 HCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE 1141
HCSAG GRTG YI ID ML+ E E VD+Y V LR +R MVQ E QYI IH A++E
Sbjct: 802 HCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVE 861
Query: 1142 ACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTP-RLQAEDCSIACLPR 1200
GET + + E +M + D + S L+ EFQ L S R Q I
Sbjct: 862 YNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ----HIGNQEE 917
Query: 1201 NHDKNRFMDMLPPD-RCLPFLITID-------------------GESSNYINAALMDSYR 1240
N KNR +++P D +P ++ E S YINA+ + SY
Sbjct: 918 NKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYW 977
Query: 1241 QPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPI 1298
+P I Q PL T+ DFW++++ IVML E+ + C QYW EG YG I
Sbjct: 978 KPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDI 1036
Query: 1299 QVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQ 1358
+V+ R+F + + R V Q+QY W S ++P + + +I
Sbjct: 1037 EVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKELISMIQV 1093
Query: 1359 VEKWQEECEEGEGR-------TIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKT 1411
V++ + EG +IHC +G ++G+FCA+ ++E + + VVD+F VK
Sbjct: 1094 VKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKA 1153
Query: 1412 LRNSKPNMVEAPEQYRFCYDV 1432
LR ++P MV EQY+F YDV
Sbjct: 1154 LRKARPGMVSTFEQYQFLYDV 1174
Score = 163 bits (412), Expect = 1e-39
Identities = 100/306 (32%), Positives = 158/306 (51%), Gaps = 34/306 (11%)
Query: 868 IRVADLLQHINLMKTSDSYGFKEEYESFFEGQSA--SW---DVAKKDQNRAKNRYGNIIA 922
+ +++L +++ MK D E+ F+ + SW + +++N++KNR N+I
Sbjct: 870 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 929
Query: 923 YDHSRVILQPV---------EDDPSSD----------YINANYIDGYQRPSHYIATQGPV 963
YD++RV L+ + D SSD YINA++I Y +P IA QGP+
Sbjct: 930 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 989
Query: 964 HETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEY 1023
ET+ DFW+MI+Q + IVM+T L + C +YW + + YGD +V + + + Y
Sbjct: 990 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTY 1049
Query: 1024 VVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPS-------- 1075
+R F L + R V Q+ +T W +P L+S I+ VK P
Sbjct: 1050 TLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKH 1109
Query: 1076 --AGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYI 1133
+ P+++HC G+ +TG + + +L+ AE E VVDI+ VKALR R MV T EQY
Sbjct: 1110 HKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQ 1169
Query: 1134 FIHDAI 1139
F++D I
Sbjct: 1170 FLYDVI 1175
Score = 122 bits (306), Expect = 2e-27
Identities = 84/265 (31%), Positives = 130/265 (49%), Gaps = 13/265 (4%)
Query: 1177 EFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGES-SNYINAAL 1235
EFQ++ V + ++ A P N +KNR++D+LP D L I+G++ SNYINA+
Sbjct: 606 EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 662
Query: 1236 MDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQG--CPQYWP--EEG 1291
+D +++P +I Q P TV DFWR++++ T IVM+ + C +YWP EEG
Sbjct: 663 IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 722
Query: 1292 MLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRS 1351
+G + V+ D I + I N G V Q+ W H VP
Sbjct: 723 TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGR-EVTHIQFTSWPDHG-VPEDPHL 780
Query: 1352 FLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKT 1411
LKL +V + G ++HC G GR+G + I ++E ++ +N VDV+ V
Sbjct: 781 LLKLRRRVNAFSNFFS---GPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 837
Query: 1412 LRNSKPNMVEAPEQYRFCYDVALEY 1436
LR + MV+ QY + +EY
Sbjct: 838 LRRQRCLMVQVEAQYILIHQALVEY 862
Score = 33.9 bits (76), Expect = 1.2
Identities = 26/106 (24%), Positives = 47/106 (44%), Gaps = 9/106 (8%)
Query: 424 NVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKM---ILTNPEGRKESEE 480
N T+CY E++ DCL++D ++ + +L PYT L + I+ + +
Sbjct: 371 NFTLCYI-----KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAM 425
Query: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEI 526
T P V ++ TS +N + + + P D NG +Y +
Sbjct: 426 CHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDRNGPHERYHL 470
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
precursor [Homo sapiens]
Length = 1304
Score = 337 bits (864), Expect = 5e-92
Identities = 210/561 (37%), Positives = 293/561 (52%), Gaps = 42/561 (7%)
Query: 906 AKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHE 965
A+K N+ KNRY +I+ YD++RV L + D S+YINA+YIDG++ P YIA QGP E
Sbjct: 670 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 729
Query: 966 TVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP---DDTEVYGDFKVTCVEMEPLAE 1022
TV DFWRMIW++++ IVMVT E R KC +YWP + T +GD V + + +
Sbjct: 730 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 789
Query: 1023 YVVRTFTLERRGYNEI-REVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVV 1081
Y+++ + + REV FT WPDHGVP LL RRV + +GPIVV
Sbjct: 790 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVV 849
Query: 1082 HCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE 1141
HCSAG GRTG YI ID ML+ E E VD+Y V LR +R MVQ E QYI IH A++E
Sbjct: 850 HCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVE 909
Query: 1142 ACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTP-RLQAEDCSIACLPR 1200
GET + + E +M + D + S L+ EFQ L S R Q I
Sbjct: 910 YNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ----HIGNQEE 965
Query: 1201 NHDKNRFMDMLPPD-RCLPFLITID-------------------GESSNYINAALMDSYR 1240
N KNR +++P D +P ++ E S YINA+ + SY
Sbjct: 966 NKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYW 1025
Query: 1241 QPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPI 1298
+P I Q PL T+ DFW++++ IVML E+ + C QYW EG YG I
Sbjct: 1026 KPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDI 1084
Query: 1299 QVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQ 1358
+V+ R+F + + R V Q+QY W S ++P + + +I
Sbjct: 1085 EVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKELISMIQV 1141
Query: 1359 VEKWQEECEEGEGR-------TIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKT 1411
V++ + EG +IHC +G ++G+FCA+ ++E + + VVD+F VK
Sbjct: 1142 VKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKA 1201
Query: 1412 LRNSKPNMVEAPEQYRFCYDV 1432
LR ++P MV EQY+F YDV
Sbjct: 1202 LRKARPGMVSTFEQYQFLYDV 1222
Score = 163 bits (412), Expect = 1e-39
Identities = 100/306 (32%), Positives = 158/306 (51%), Gaps = 34/306 (11%)
Query: 868 IRVADLLQHINLMKTSDSYGFKEEYESFFEGQSA--SW---DVAKKDQNRAKNRYGNIIA 922
+ +++L +++ MK D E+ F+ + SW + +++N++KNR N+I
Sbjct: 918 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 977
Query: 923 YDHSRVILQPV---------EDDPSSD----------YINANYIDGYQRPSHYIATQGPV 963
YD++RV L+ + D SSD YINA++I Y +P IA QGP+
Sbjct: 978 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 1037
Query: 964 HETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEY 1023
ET+ DFW+MI+Q + IVM+T L + C +YW + + YGD +V + + + Y
Sbjct: 1038 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTY 1097
Query: 1024 VVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPS-------- 1075
+R F L + R V Q+ +T W +P L+S I+ VK P
Sbjct: 1098 TLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKH 1157
Query: 1076 --AGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYI 1133
+ P+++HC G+ +TG + + +L+ AE E VVDI+ VKALR R MV T EQY
Sbjct: 1158 HKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQ 1217
Query: 1134 FIHDAI 1139
F++D I
Sbjct: 1218 FLYDVI 1223
Score = 122 bits (306), Expect = 2e-27
Identities = 84/265 (31%), Positives = 130/265 (49%), Gaps = 13/265 (4%)
Query: 1177 EFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGES-SNYINAAL 1235
EFQ++ V + ++ A P N +KNR++D+LP D L I+G++ SNYINA+
Sbjct: 654 EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 710
Query: 1236 MDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQG--CPQYWP--EEG 1291
+D +++P +I Q P TV DFWR++++ T IVM+ + C +YWP EEG
Sbjct: 711 IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 770
Query: 1292 MLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRS 1351
+G + V+ D I + I N G V Q+ W H VP
Sbjct: 771 TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGR-EVTHIQFTSWPDHG-VPEDPHL 828
Query: 1352 FLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKT 1411
LKL +V + G ++HC G GR+G + I ++E ++ +N VDV+ V
Sbjct: 829 LLKLRRRVNAFSNFFS---GPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 885
Query: 1412 LRNSKPNMVEAPEQYRFCYDVALEY 1436
LR + MV+ QY + +EY
Sbjct: 886 LRRQRCLMVQVEAQYILIHQALVEY 910
Score = 33.9 bits (76), Expect = 1.2
Identities = 26/106 (24%), Positives = 47/106 (44%), Gaps = 9/106 (8%)
Query: 424 NVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKM---ILTNPEGRKESEE 480
N T+CY E++ DCL++D ++ + +L PYT L + I+ + +
Sbjct: 419 NFTLCYI-----KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAM 473
Query: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEI 526
T P V ++ TS +N + + + P D NG +Y +
Sbjct: 474 CHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDRNGPHERYHL 518
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
precursor [Homo sapiens]
Length = 1143
Score = 337 bits (864), Expect = 5e-92
Identities = 210/561 (37%), Positives = 293/561 (52%), Gaps = 42/561 (7%)
Query: 906 AKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHE 965
A+K N+ KNRY +I+ YD++RV L + D S+YINA+YIDG++ P YIA QGP E
Sbjct: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568
Query: 966 TVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP---DDTEVYGDFKVTCVEMEPLAE 1022
TV DFWRMIW++++ IVMVT E R KC +YWP + T +GD V + + +
Sbjct: 569 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628
Query: 1023 YVVRTFTLERRGYNEI-REVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVV 1081
Y+++ + + REV FT WPDHGVP LL RRV + +GPIVV
Sbjct: 629 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVV 688
Query: 1082 HCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE 1141
HCSAG GRTG YI ID ML+ E E VD+Y V LR +R MVQ E QYI IH A++E
Sbjct: 689 HCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVE 748
Query: 1142 ACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTP-RLQAEDCSIACLPR 1200
GET + + E +M + D + S L+ EFQ L S R Q I
Sbjct: 749 YNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ----HIGNQEE 804
Query: 1201 NHDKNRFMDMLPPD-RCLPFLITID-------------------GESSNYINAALMDSYR 1240
N KNR +++P D +P ++ E S YINA+ + SY
Sbjct: 805 NKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYW 864
Query: 1241 QPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPI 1298
+P I Q PL T+ DFW++++ IVML E+ + C QYW EG YG I
Sbjct: 865 KPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDI 923
Query: 1299 QVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQ 1358
+V+ R+F + + R V Q+QY W S ++P + + +I
Sbjct: 924 EVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKELISMIQV 980
Query: 1359 VEKWQEECEEGEGR-------TIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKT 1411
V++ + EG +IHC +G ++G+FCA+ ++E + + VVD+F VK
Sbjct: 981 VKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKA 1040
Query: 1412 LRNSKPNMVEAPEQYRFCYDV 1432
LR ++P MV EQY+F YDV
Sbjct: 1041 LRKARPGMVSTFEQYQFLYDV 1061
Score = 163 bits (412), Expect = 1e-39
Identities = 100/306 (32%), Positives = 158/306 (51%), Gaps = 34/306 (11%)
Query: 868 IRVADLLQHINLMKTSDSYGFKEEYESFFEGQSA--SW---DVAKKDQNRAKNRYGNIIA 922
+ +++L +++ MK D E+ F+ + SW + +++N++KNR N+I
Sbjct: 757 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 816
Query: 923 YDHSRVILQPV---------EDDPSSD----------YINANYIDGYQRPSHYIATQGPV 963
YD++RV L+ + D SSD YINA++I Y +P IA QGP+
Sbjct: 817 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 876
Query: 964 HETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEY 1023
ET+ DFW+MI+Q + IVM+T L + C +YW + + YGD +V + + + Y
Sbjct: 877 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTY 936
Query: 1024 VVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPS-------- 1075
+R F L + R V Q+ +T W +P L+S I+ VK P
Sbjct: 937 TLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKH 996
Query: 1076 --AGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYI 1133
+ P+++HC G+ +TG + + +L+ AE E VVDI+ VKALR R MV T EQY
Sbjct: 997 HKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQ 1056
Query: 1134 FIHDAI 1139
F++D I
Sbjct: 1057 FLYDVI 1062
Score = 122 bits (306), Expect = 2e-27
Identities = 84/265 (31%), Positives = 130/265 (49%), Gaps = 13/265 (4%)
Query: 1177 EFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGES-SNYINAAL 1235
EFQ++ V + ++ A P N +KNR++D+LP D L I+G++ SNYINA+
Sbjct: 493 EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 549
Query: 1236 MDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQG--CPQYWP--EEG 1291
+D +++P +I Q P TV DFWR++++ T IVM+ + C +YWP EEG
Sbjct: 550 IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 609
Query: 1292 MLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRS 1351
+G + V+ D I + I N G V Q+ W H VP
Sbjct: 610 TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGR-EVTHIQFTSWPDHG-VPEDPHL 667
Query: 1352 FLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKT 1411
LKL +V + G ++HC G GR+G + I ++E ++ +N VDV+ V
Sbjct: 668 LLKLRRRVNAFSNFFS---GPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 724
Query: 1412 LRNSKPNMVEAPEQYRFCYDVALEY 1436
LR + MV+ QY + +EY
Sbjct: 725 LRRQRCLMVQVEAQYILIHQALVEY 749
Score = 33.9 bits (76), Expect = 1.2
Identities = 26/106 (24%), Positives = 47/106 (44%), Gaps = 9/106 (8%)
Query: 424 NVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKM---ILTNPEGRKESEE 480
N T+CY E++ DCL++D ++ + +L PYT L + I+ + +
Sbjct: 258 NFTLCYI-----KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAM 312
Query: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEI 526
T P V ++ TS +N + + + P D NG +Y +
Sbjct: 313 CHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDRNGPHERYHL 357
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,484,687
Number of Sequences: 37866
Number of extensions: 2953181
Number of successful extensions: 8894
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 134
Number of HSP's successfully gapped in prelim test: 138
Number of HSP's that attempted gapping in prelim test: 7053
Number of HSP's gapped (non-prelim): 1141
length of query: 1440
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1325
effective length of database: 13,892,928
effective search space: 18408129600
effective search space used: 18408129600
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.