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Search of human proteins with 18860894
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18860894 protein tyrosine phosphatase, receptor type, D
isoform 4 precursor [Homo sapiens]
(1501 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 3036 0.0
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 3020 0.0
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 2338 0.0
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 2325 0.0
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 1897 0.0
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 1894 0.0
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 1894 0.0
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 1506 0.0
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 1492 0.0
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 1451 0.0
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 1449 0.0
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 602 e-172
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 601 e-171
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 601 e-171
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor... 556 e-158
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo... 550 e-156
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 510 e-144
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 509 e-144
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 504 e-142
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 503 e-142
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 498 e-140
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 498 e-140
gi|110735404 protein tyrosine phosphatase, receptor type, U isof... 464 e-130
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 459 e-129
gi|110735406 protein tyrosine phosphatase, receptor type, U isof... 458 e-128
gi|110735402 protein tyrosine phosphatase, receptor type, U isof... 449 e-126
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 424 e-118
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 396 e-110
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 396 e-110
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 396 e-110
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 3036 bits (7872), Expect = 0.0
Identities = 1501/1501 (100%), Positives = 1501/1501 (100%)
Query: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
Query: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
Query: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI
Sbjct: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
Query: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
Query: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
Query: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
Query: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
Query: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
Query: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
Query: 601 SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKL 660
SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKL
Sbjct: 601 SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKL 660
Query: 661 IVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEV 720
IVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEV
Sbjct: 661 IVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEV 720
Query: 721 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPY 780
PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPY
Sbjct: 721 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPY 780
Query: 781 IAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVV 840
IAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVV
Sbjct: 781 IAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVV 840
Query: 841 SMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIP 900
SMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIP
Sbjct: 841 SMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIP 900
Query: 901 SHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFT 960
SHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFT
Sbjct: 901 SHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFT 960
Query: 961 WEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGS 1020
WEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGS
Sbjct: 961 WEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGS 1020
Query: 1021 LPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELA 1080
LPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELA
Sbjct: 1021 LPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELA 1080
Query: 1081 TYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVV 1140
TYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVV
Sbjct: 1081 TYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVV 1140
Query: 1141 HCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE 1200
HCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
Sbjct: 1141 HCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE 1200
Query: 1201 AVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKF 1260
AVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKF
Sbjct: 1201 AVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKF 1260
Query: 1261 KNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRM 1320
KNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRM
Sbjct: 1261 KNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRM 1320
Query: 1321 LWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD 1380
LWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD
Sbjct: 1321 LWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD 1380
Query: 1381 ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRT 1440
ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRT
Sbjct: 1381 ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRT 1440
Query: 1441 GVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1500
GVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA
Sbjct: 1441 GVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1500
Query: 1501 T 1501
T
Sbjct: 1501 T 1501
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 3020 bits (7830), Expect = 0.0
Identities = 1498/1505 (99%), Positives = 1498/1505 (99%), Gaps = 7/1505 (0%)
Query: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
Query: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
Query: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
GGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI
Sbjct: 181 ---GGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 237
Query: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 238 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 297
Query: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 298 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 357
Query: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 358 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 417
Query: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 418 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 477
Query: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 478 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 537
Query: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 538 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 597
Query: 601 SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKL 660
SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKL
Sbjct: 598 SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKL 657
Query: 661 IVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEV 720
IVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEV
Sbjct: 658 IVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEV 717
Query: 721 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPY 780
PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPY
Sbjct: 718 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPY 777
Query: 781 IAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVV 840
IAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVV
Sbjct: 778 IAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVV 837
Query: 841 SMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYK----RKRAESDSRKSSIPNN 896
SMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYK RKRAESDSRKSSIPNN
Sbjct: 838 SMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNN 897
Query: 897 KEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPG 956
KEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPG
Sbjct: 898 KEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPG 957
Query: 957 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIA 1016
QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIA
Sbjct: 958 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIA 1017
Query: 1017 TQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDT 1076
TQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDT
Sbjct: 1018 TQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDT 1077
Query: 1077 VELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAG 1136
VELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAG
Sbjct: 1078 VELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAG 1137
Query: 1137 PMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHD 1196
PMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHD
Sbjct: 1138 PMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHD 1197
Query: 1197 ALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLP 1256
ALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLP
Sbjct: 1198 ALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLP 1257
Query: 1257 CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1316
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED
Sbjct: 1258 CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1317
Query: 1317 FWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1376
FWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF
Sbjct: 1318 FWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1377
Query: 1377 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAG 1436
KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAG
Sbjct: 1378 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAG 1437
Query: 1437 VGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF 1496
VGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF
Sbjct: 1438 VGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF 1497
Query: 1497 DHYAT 1501
DHYAT
Sbjct: 1498 DHYAT 1502
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 2338 bits (6058), Expect = 0.0
Identities = 1139/1489 (76%), Positives = 1300/1489 (87%), Gaps = 19/1489 (1%)
Query: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
Query: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS GALQIE SEE
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS---------GALQIESSEE 199
Query: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
+DQGKYECVATNSAG RYS+PANLYVRELREVRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200 TDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVA 259
Query: 260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319
VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 260 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 319
Query: 320 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379
K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS
Sbjct: 320 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 379
Query: 380 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439
+ GLSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 380 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 439
Query: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
EP EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+G
Sbjct: 440 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 499
Query: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559
DGPLS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 500 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 559
Query: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVM 619
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+QS+ KNF VK +M
Sbjct: 560 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIM 619
Query: 620 KTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGN 679
KTSVLLSWE P+NYNS P+KI Y+ + +VDGR T+KLI +LKP Y+FVLTNRG+
Sbjct: 620 KTSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGS 677
Query: 680 SAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKS 739
S GGLQ VTA TA ++L KP+ K + DG I V LP+ + ++ Y+I++VPL+KS
Sbjct: 678 SLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKS 737
Query: 740 RG-KFIKPWESPDEMELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGD 796
RG +F+ P SP++M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP F GD
Sbjct: 738 RGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGD 797
Query: 797 DKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGL 856
K YGGF N+ L+ G YV FVLAV++ +E +A SP+SDP + DPQPI D EEGL
Sbjct: 798 QKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGL 856
Query: 857 IWVVGPVLAVVFIICIVIAILLYKRK----RAESDSRKSSIPNNKEIPSHHPTDPVELRR 912
IWV+GPVLAVVFIICIVIAILLYK K R +S+ R + NN ++ HHP DPVE+RR
Sbjct: 857 IWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRR 916
Query: 913 LNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPK 972
+NFQTPGM SHPPIPI ++A+H ERLKAND+LK SQEYESIDPGQQFTWEHSNLEVNKPK
Sbjct: 917 INFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPK 976
Query: 973 NRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMI 1032
NRYANVIAYDHSRV+L IEGI GSDY+NANY+DGYR QNAYIATQG LPETFGDFWRM+
Sbjct: 977 NRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMV 1036
Query: 1033 WEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKN 1092
WEQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KN
Sbjct: 1037 WEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKN 1096
Query: 1093 GSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCF 1152
GSSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCF
Sbjct: 1097 GSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCF 1156
Query: 1153 IVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPAR 1212
IVIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR
Sbjct: 1157 IVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPAR 1216
Query: 1213 NLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYES 1272
+LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFISANLPCNKFKNRLVNIMPYES
Sbjct: 1217 SLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYES 1276
Query: 1273 TRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVML 1332
TRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE+NSTIVVML
Sbjct: 1277 TRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVML 1336
Query: 1333 TKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQF 1392
TKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQF
Sbjct: 1337 TKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQF 1396
Query: 1393 QFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLER 1452
QFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLER
Sbjct: 1397 QFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLER 1456
Query: 1453 MRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1501
MRYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1457 MRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1505
Score = 94.4 bits (233), Expect = 8e-19
Identities = 113/473 (23%), Positives = 188/473 (39%), Gaps = 90/473 (19%)
Query: 16 LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75
LR PRF+ P+ + GG + C A G P P + W Q E + +
Sbjct: 228 LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 279
Query: 76 DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135
D + L +D A Y CVA +++G I ++TV + P G P
Sbjct: 280 DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 330
Query: 136 VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIE 195
V E T T+ + SGNPDP ++++ IE
Sbjct: 331 VTENTATSITITWDSGNPDP-VSYY--------------------------------VIE 357
Query: 196 QSEESDQGKYECVATNSAGTRYS-------APANLYVRELREVRRVPPRFSIPPTNHEIM 248
+S G Y+ + + TRYS + ++V + + + PP S+ E
Sbjct: 358 YKSKSQDGPYQ-IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQA 416
Query: 249 PGGSV-NITCVAVGSPMPYVKWMLGAED----------LTPEDDMPIG----RNV----- 288
P + N+ + + V+W E T E + P+G NV
Sbjct: 417 PASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLL 476
Query: 289 LELNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTW 343
+ + + YT +A +++G I VK PG P+ + A TSITL+W
Sbjct: 477 TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSW 536
Query: 344 DSGNPEP-VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRG 402
E + Y ++ + + E+ + D TT Y V L P ++Y FR+ A + G G
Sbjct: 537 SPPRQESIIKYELLFREGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLG 594
Query: 403 PPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY 455
PV+ Q + Q S +P++ + +M+ T++L+ W+ P+ N Y++ Y
Sbjct: 595 -AFTPVVRQRTLQ--SISPKNFKVKMIMKTSVLLSWEFPDNYNSPTP-YKIQY 643
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 2325 bits (6024), Expect = 0.0
Identities = 1135/1489 (76%), Positives = 1296/1489 (87%), Gaps = 23/1489 (1%)
Query: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
Query: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS GALQIE SEE
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS---------GALQIESSEE 199
Query: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
+DQGKYECVATNSAG RYS+PANLYVR VRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200 TDQGKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSILPMSHEIMPGGNVNITCVA 255
Query: 260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319
VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 256 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 315
Query: 320 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379
K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS
Sbjct: 316 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 375
Query: 380 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439
+ GLSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 376 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 435
Query: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
EP EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+G
Sbjct: 436 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 495
Query: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559
DGPLS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 496 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 555
Query: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVM 619
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+QS+ KNF VK +M
Sbjct: 556 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIM 615
Query: 620 KTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGN 679
KTSVLLSWE P+NYNS P+KI Y+ + +VDGR T+KLI +LKP Y+FVLTNRG+
Sbjct: 616 KTSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGS 673
Query: 680 SAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKS 739
S GGLQ VTA TA ++L KP+ K + DG I V LP+ + ++ Y+I++VPL+KS
Sbjct: 674 SLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKS 733
Query: 740 RG-KFIKPWESPDEMELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGD 796
RG +F+ P SP++M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP F GD
Sbjct: 734 RGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGD 793
Query: 797 DKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGL 856
K YGGF N+ L+ G YV FVLAV++ +E +A SP+SDP + DPQPI D EEGL
Sbjct: 794 QKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGL 852
Query: 857 IWVVGPVLAVVFIICIVIAILLYKRK----RAESDSRKSSIPNNKEIPSHHPTDPVELRR 912
IWV+GPVLAVVFIICIVIAILLYK K R +S+ R + NN ++ HHP DPVE+RR
Sbjct: 853 IWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRR 912
Query: 913 LNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPK 972
+NFQTPGM SHPPIPI ++A+H ERLKAND+LK SQEYESIDPGQQFTWEHSNLEVNKPK
Sbjct: 913 INFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPK 972
Query: 973 NRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMI 1032
NRYANVIAYDHSRV+L IEGI GSDY+NANY+DGYR QNAYIATQG LPETFGDFWRM+
Sbjct: 973 NRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMV 1032
Query: 1033 WEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKN 1092
WEQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KN
Sbjct: 1033 WEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKN 1092
Query: 1093 GSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCF 1152
GSSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCF
Sbjct: 1093 GSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCF 1152
Query: 1153 IVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPAR 1212
IVIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR
Sbjct: 1153 IVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPAR 1212
Query: 1213 NLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYES 1272
+LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFISANLPCNKFKNRLVNIMPYES
Sbjct: 1213 SLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYES 1272
Query: 1273 TRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVML 1332
TRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE+NSTIVVML
Sbjct: 1273 TRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVML 1332
Query: 1333 TKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQF 1392
TKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQF
Sbjct: 1333 TKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQF 1392
Query: 1393 QFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLER 1452
QFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLER
Sbjct: 1393 QFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLER 1452
Query: 1453 MRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1501
MRYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1453 MRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1501
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 1897 bits (4913), Expect = 0.0
Identities = 966/1199 (80%), Positives = 1021/1199 (85%), Gaps = 31/1199 (2%)
Query: 325 PPGTPVVTESTATSITLTWDSGNPEP---------VSYYIIQHKPKNSEELYKEIDGVAT 375
PP V +TS+ ++W S P V Y +++ + + K++
Sbjct: 714 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
Query: 376 TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTIL 435
++GL P + Y V A G G S+P L T+ P PR V T L
Sbjct: 774 QDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLV-INHTQMNTAL 831
Query: 436 VQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAF 495
+QW P + G +QGYR+ + + + D T ++ +Y ++ A
Sbjct: 832 IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT--DIHKGASYVFRLSAR 889
Query: 496 TSIGDGPLSSDIQVITQTGVP-----GQPLNFKAEPESETSILLSWTPP----RSDTIAN 546
+G G +++ + +P G P N +E + TS+ LSW PP R+ I
Sbjct: 890 NKVGFGE-----EMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITK 944
Query: 547 YELVYKDGEHG--EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISART 604
Y L+Y+D +++ + T+ L GLKP++ Y ++ A + +G G + + RT
Sbjct: 945 YTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1004
Query: 605 M--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIV 662
+ +FAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIV
Sbjct: 1005 LPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIV 1064
Query: 663 NLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA 722
NLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA
Sbjct: 1065 NLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA 1124
Query: 723 NENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIA 782
NENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIA
Sbjct: 1125 NENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIA 1184
Query: 783 AHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSM 842
AHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSM
Sbjct: 1185 AHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSM 1244
Query: 843 DLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH 902
DLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH
Sbjct: 1245 DLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH 1304
Query: 903 HPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWE 962
HPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWE
Sbjct: 1305 HPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWE 1364
Query: 963 HSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP 1022
HSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP
Sbjct: 1365 HSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP 1424
Query: 1023 ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATY 1082
ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATY
Sbjct: 1425 ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATY 1484
Query: 1083 CVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHC 1142
CVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHC
Sbjct: 1485 CVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHC 1544
Query: 1143 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1202
SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
Sbjct: 1545 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1604
Query: 1203 TCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKN 1262
TCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKN
Sbjct: 1605 TCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKN 1664
Query: 1263 RLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLW 1322
RLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLW
Sbjct: 1665 RLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLW 1724
Query: 1323 EHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR 1382
EHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR
Sbjct: 1725 EHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR 1784
Query: 1383 DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGV 1442
DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGV
Sbjct: 1785 DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGV 1844
Query: 1443 FITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1501
FITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT
Sbjct: 1845 FITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1903
Score = 1226 bits (3172), Expect = 0.0
Identities = 613/633 (96%), Positives = 620/633 (97%), Gaps = 3/633 (0%)
Query: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
Query: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
Query: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI
Sbjct: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
Query: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
Query: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
Query: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
Query: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
Query: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
Query: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
Query: 601 SARTMQSMFA---KNFHVKAVMKTSVLLSWEIP 630
SARTMQS + ++ + TS+L+SW+ P
Sbjct: 601 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPP 633
Score = 138 bits (347), Expect = 5e-32
Identities = 124/428 (28%), Positives = 195/428 (45%), Gaps = 37/428 (8%)
Query: 300 YTCVAMSTLGVIEAIAQITVKALPKPPGTPV----VTESTATSITLTWDSGNPEPVSYYI 355
+ A S G+ + A+I+ + + P P T ++TSI ++W E + I
Sbjct: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
Query: 356 IQHKPK-----NSEELYKEIDGVA--TTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 408
++ K ++ EI G+ TT+Y + L +++Y V A ++G GP S V
Sbjct: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702
Query: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKE--PEEPNGQIQGYRVYYT-MDPTQHVNN 465
L +T+E PS PR V+ ++ST++ V W+ P + +GQI+GY+V+Y M+ +
Sbjct: 703 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 762
Query: 466 WMKHNV--ADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK 523
M +V AD+Q I L P+ +YS+ V A+T+ GDG S V T VPG+P
Sbjct: 763 PMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVI 822
Query: 524 AEPESETSILLSWTPPRSDT---IANYELVYKDGEHGEEQRITI---EPGTSYRLQGLKP 577
+ T+ L+ W PP DT + Y L K G E T+ E + +
Sbjct: 823 NHTQMNTA-LIQWHPP-VDTFGPLQGYRL--KFGRKDMEPLTTLEFSEKEDHFTATDIHK 878
Query: 578 NSLYYFRLAARSPQGLGAS-TAEIS-ARTMQSMFAKNFHVKAVMKTSVLLSWEIP---EN 632
+ Y FRL+AR+ G G EIS + + F +N H + TSV LSW+ P E
Sbjct: 879 GASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAER 938
Query: 633 YNSAMPFKILYDDGK-----MVEEVDGRATQKLIVNLKPEKSYSF-VLTNRGNSAGGLQH 686
+ +LY D M + + T + LKP+ +Y V + G
Sbjct: 939 NGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSP 998
Query: 687 RVTAKTAP 694
V +T P
Sbjct: 999 SVQFRTLP 1006
Score = 98.2 bits (243), Expect = 5e-20
Identities = 138/611 (22%), Positives = 239/611 (39%), Gaps = 92/611 (15%)
Query: 143 ATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQ 202
A+ +C A+G+P P+I W K V +N R + + + G+ +R +Q ++ D+
Sbjct: 41 ASFICQATGDPRPKIVWNKKGKKV----SNQRFEVIEFDDGSGSVLR--IQPLRTPR-DE 93
Query: 203 GKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGS 262
YECVA+N+ G S L V ++ R P + P + + + C A G+
Sbjct: 94 AIYECVASNNVG-EISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGN 152
Query: 263 PMPYVKWMLGAEDLTPEDDM-----------------PI-GRNVLELNDVRQSANYTCVA 304
P P + W +D P D PI G +E ++ Y CVA
Sbjct: 153 PDPEITWF---KDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVA 209
Query: 305 MSTLGV-IEAIAQITVKALPK----------PPGTPVVTESTATSITLTWDSGNPEPVSY 353
++ G A A + V+ L + PP + + +IT G+P P
Sbjct: 210 TNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCV-AVGSPMPYVK 268
Query: 354 YIIQHK---PKNSEELYKEI----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSE 406
+++ + P++ + + + D + Y+ +S E PP
Sbjct: 269 WMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGT 328
Query: 407 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNN 465
PV+T+++ +T+I + W EP V Y + + N+
Sbjct: 329 PVVTEST-----------------ATSITLTWDSGNPEP--------VSYYIIQHKPKNS 363
Query: 466 WMKHNVADSQITT---IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLN 521
+ D TT + L P Y +V+A +IG GP S + T P P +
Sbjct: 364 EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 423
Query: 522 FKAEPESETSILLSWTPPRSDT--IANYELVYK--DGEHGEE-QRITIEPGTSYRLQGLK 576
+A S T+IL+ W P I Y + Y +H + + + L
Sbjct: 424 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 483
Query: 577 PNSLYYFRLAARSPQGLGASTAEISARTMQSMFAK--NFHVKAVMKTSVLLSWEIPENYN 634
P Y ++ A + G G +++I T + + NF + +TS+LLSW P + +
Sbjct: 484 PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRS-D 542
Query: 635 SAMPFKILYDDGKMVEE---VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAK 691
+ ++++Y DG+ EE T + LKP Y F L R G TA+
Sbjct: 543 TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAS---TAE 599
Query: 692 TAPDVLRTKPA 702
+ +++KP+
Sbjct: 600 ISARTMQSKPS 610
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 1894 bits (4905), Expect = 0.0
Identities = 967/1208 (80%), Positives = 1022/1208 (84%), Gaps = 40/1208 (3%)
Query: 325 PPGTPVVTESTATSITLTWDSGNPEP---------VSYYIIQHKPKNSEELYKEI----- 370
PP V +TS+ ++W S P V Y +++ + + K++
Sbjct: 714 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
Query: 371 ----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQA 426
D ++GL P + Y V A G G S+P L T+ P PR V
Sbjct: 774 QWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLV-I 831
Query: 427 RMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQK 486
T L+QW P + G +QGYR+ + + + D T ++
Sbjct: 832 NHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT--DIHKGA 889
Query: 487 TYSVKVLAFTSIGDGPLSSDIQVITQTGVP-----GQPLNFKAEPESETSILLSWTPP-- 539
+Y ++ A +G G +++ + +P G P N +E + TS+ LSW PP
Sbjct: 890 SYVFRLSARNKVGFGE-----EMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVL 944
Query: 540 --RSDTIANYELVYKDGEHG--EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGA 595
R+ I Y L+Y+D +++ + T+ L GLKP++ Y ++ A + +G G
Sbjct: 945 AERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 1004
Query: 596 STAEISARTM--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD 653
+ + RT+ +FAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD
Sbjct: 1005 YSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD 1064
Query: 654 GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI 713
GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI
Sbjct: 1065 GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI 1124
Query: 714 TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR 773
TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR
Sbjct: 1125 TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR 1184
Query: 774 EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS 833
EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS
Sbjct: 1185 EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS 1244
Query: 834 PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSI 893
PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSI
Sbjct: 1245 PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSI 1304
Query: 894 PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESI 953
PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESI
Sbjct: 1305 PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESI 1364
Query: 954 DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNA 1013
DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNA
Sbjct: 1365 DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNA 1424
Query: 1014 YIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTL 1073
YIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTL
Sbjct: 1425 YIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTL 1484
Query: 1074 LDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP 1133
LDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP
Sbjct: 1485 LDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP 1544
Query: 1134 DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIF 1193
DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIF
Sbjct: 1545 DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIF 1604
Query: 1194 IHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISA 1253
IHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISA
Sbjct: 1605 IHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISA 1664
Query: 1254 NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAET 1313
NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAET
Sbjct: 1665 NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAET 1724
Query: 1314 TEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYIL 1373
TEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYIL
Sbjct: 1725 TEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYIL 1784
Query: 1374 REFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC 1433
REFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC
Sbjct: 1785 REFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC 1844
Query: 1434 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1493
SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
Sbjct: 1845 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1904
Query: 1494 GSFDHYAT 1501
GSFDHYAT
Sbjct: 1905 GSFDHYAT 1912
Score = 1226 bits (3172), Expect = 0.0
Identities = 613/633 (96%), Positives = 620/633 (97%), Gaps = 3/633 (0%)
Query: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
Query: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
Query: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI
Sbjct: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
Query: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
Query: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
Query: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
Query: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
Query: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
Query: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
Query: 601 SARTMQSMFA---KNFHVKAVMKTSVLLSWEIP 630
SARTMQS + ++ + TS+L+SW+ P
Sbjct: 601 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPP 633
Score = 130 bits (328), Expect = 7e-30
Identities = 126/437 (28%), Positives = 197/437 (45%), Gaps = 46/437 (10%)
Query: 300 YTCVAMSTLGVIEAIAQITVKALPKPPGTPV----VTESTATSITLTWDSGNPEPVSYYI 355
+ A S G+ + A+I+ + + P P T ++TSI ++W E + I
Sbjct: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
Query: 356 IQHKPK-----NSEELYKEIDGVA--TTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 408
++ K ++ EI G+ TT+Y + L +++Y V A ++G GP S V
Sbjct: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702
Query: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKE--PEEPNGQIQGYRVYYT-MDPTQHVNN 465
L +T+E PS PR V+ ++ST++ V W+ P + +GQI+GY+V+Y M+ +
Sbjct: 703 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 762
Query: 466 WMKHNV--ADSQ----ITT-----IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTG 514
M +V AD+Q TT I L P+ +YS+ V A+T+ GDG S V T
Sbjct: 763 PMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA 822
Query: 515 VPGQPLNFKAEPESETSILLSWTPPRSDT---IANYELVYKDGEHGEEQRITI---EPGT 568
VPG+P + T+ L+ W PP DT + Y L K G E T+ E
Sbjct: 823 VPGKPRLVINHTQMNTA-LIQWHPP-VDTFGPLQGYRL--KFGRKDMEPLTTLEFSEKED 878
Query: 569 SYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEIS-ARTMQSMFAKNFHVKAVMKTSVLLS 626
+ + + Y FRL+AR+ G G EIS + + F +N H + TSV LS
Sbjct: 879 HFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLS 938
Query: 627 WEIP---ENYNSAMPFKILYDDGK-----MVEEVDGRATQKLIVNLKPEKSYSF-VLTNR 677
W+ P E + +LY D M + + T + LKP+ +Y V +
Sbjct: 939 WQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHT 998
Query: 678 GNSAGGLQHRVTAKTAP 694
G V +T P
Sbjct: 999 SKGPGPYSPSVQFRTLP 1015
Score = 98.2 bits (243), Expect = 5e-20
Identities = 138/611 (22%), Positives = 239/611 (39%), Gaps = 92/611 (15%)
Query: 143 ATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQ 202
A+ +C A+G+P P+I W K V +N R + + + G+ +R +Q ++ D+
Sbjct: 41 ASFICQATGDPRPKIVWNKKGKKV----SNQRFEVIEFDDGSGSVLR--IQPLRTPR-DE 93
Query: 203 GKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGS 262
YECVA+N+ G S L V ++ R P + P + + + C A G+
Sbjct: 94 AIYECVASNNVG-EISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGN 152
Query: 263 PMPYVKWMLGAEDLTPEDDM-----------------PI-GRNVLELNDVRQSANYTCVA 304
P P + W +D P D PI G +E ++ Y CVA
Sbjct: 153 PDPEITWF---KDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVA 209
Query: 305 MSTLGV-IEAIAQITVKALPK----------PPGTPVVTESTATSITLTWDSGNPEPVSY 353
++ G A A + V+ L + PP + + +IT G+P P
Sbjct: 210 TNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCV-AVGSPMPYVK 268
Query: 354 YIIQHK---PKNSEELYKEI----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSE 406
+++ + P++ + + + D + Y+ +S E PP
Sbjct: 269 WMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGT 328
Query: 407 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNN 465
PV+T+++ +T+I + W EP V Y + + N+
Sbjct: 329 PVVTEST-----------------ATSITLTWDSGNPEP--------VSYYIIQHKPKNS 363
Query: 466 WMKHNVADSQITT---IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLN 521
+ D TT + L P Y +V+A +IG GP S + T P P +
Sbjct: 364 EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 423
Query: 522 FKAEPESETSILLSWTPPRSDT--IANYELVYK--DGEHGEE-QRITIEPGTSYRLQGLK 576
+A S T+IL+ W P I Y + Y +H + + + L
Sbjct: 424 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 483
Query: 577 PNSLYYFRLAARSPQGLGASTAEISARTMQSMFAK--NFHVKAVMKTSVLLSWEIPENYN 634
P Y ++ A + G G +++I T + + NF + +TS+LLSW P + +
Sbjct: 484 PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRS-D 542
Query: 635 SAMPFKILYDDGKMVEE---VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAK 691
+ ++++Y DG+ EE T + LKP Y F L R G TA+
Sbjct: 543 TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAS---TAE 599
Query: 692 TAPDVLRTKPA 702
+ +++KP+
Sbjct: 600 ISARTMQSKPS 610
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 1894 bits (4905), Expect = 0.0
Identities = 967/1208 (80%), Positives = 1022/1208 (84%), Gaps = 40/1208 (3%)
Query: 325 PPGTPVVTESTATSITLTWDSGNPEP---------VSYYIIQHKPKNSEELYKEI----- 370
PP V +TS+ ++W S P V Y +++ + + K++
Sbjct: 701 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 760
Query: 371 ----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQA 426
D ++GL P + Y V A G G S+P L T+ P PR V
Sbjct: 761 QWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLV-I 818
Query: 427 RMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQK 486
T L+QW P + G +QGYR+ + + + D T ++
Sbjct: 819 NHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT--DIHKGA 876
Query: 487 TYSVKVLAFTSIGDGPLSSDIQVITQTGVP-----GQPLNFKAEPESETSILLSWTPP-- 539
+Y ++ A +G G +++ + +P G P N +E + TS+ LSW PP
Sbjct: 877 SYVFRLSARNKVGFGE-----EMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVL 931
Query: 540 --RSDTIANYELVYKDGEHG--EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGA 595
R+ I Y L+Y+D +++ + T+ L GLKP++ Y ++ A + +G G
Sbjct: 932 AERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 991
Query: 596 STAEISARTM--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD 653
+ + RT+ +FAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD
Sbjct: 992 YSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD 1051
Query: 654 GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI 713
GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI
Sbjct: 1052 GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI 1111
Query: 714 TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR 773
TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR
Sbjct: 1112 TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR 1171
Query: 774 EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS 833
EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS
Sbjct: 1172 EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS 1231
Query: 834 PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSI 893
PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSI
Sbjct: 1232 PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSI 1291
Query: 894 PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESI 953
PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESI
Sbjct: 1292 PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESI 1351
Query: 954 DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNA 1013
DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNA
Sbjct: 1352 DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNA 1411
Query: 1014 YIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTL 1073
YIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTL
Sbjct: 1412 YIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTL 1471
Query: 1074 LDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP 1133
LDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP
Sbjct: 1472 LDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP 1531
Query: 1134 DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIF 1193
DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIF
Sbjct: 1532 DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIF 1591
Query: 1194 IHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISA 1253
IHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISA
Sbjct: 1592 IHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISA 1651
Query: 1254 NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAET 1313
NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAET
Sbjct: 1652 NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAET 1711
Query: 1314 TEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYIL 1373
TEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYIL
Sbjct: 1712 TEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYIL 1771
Query: 1374 REFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC 1433
REFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC
Sbjct: 1772 REFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC 1831
Query: 1434 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1493
SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
Sbjct: 1832 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1891
Query: 1494 GSFDHYAT 1501
GSFDHYAT
Sbjct: 1892 GSFDHYAT 1899
Score = 1187 bits (3072), Expect = 0.0
Identities = 600/633 (94%), Positives = 607/633 (95%), Gaps = 16/633 (2%)
Query: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
Query: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
Query: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
GALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVR VRRVPPRFSI
Sbjct: 181 ---------GALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVPPRFSI 227
Query: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 228 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 287
Query: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 288 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 347
Query: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 348 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 407
Query: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 408 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 467
Query: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 468 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 527
Query: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 528 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 587
Query: 601 SARTMQSMFA---KNFHVKAVMKTSVLLSWEIP 630
SARTMQS + ++ + TS+L+SW+ P
Sbjct: 588 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPP 620
Score = 130 bits (328), Expect = 7e-30
Identities = 126/437 (28%), Positives = 197/437 (45%), Gaps = 46/437 (10%)
Query: 300 YTCVAMSTLGVIEAIAQITVKALPKPPGTPV----VTESTATSITLTWDSGNPEPVSYYI 355
+ A S G+ + A+I+ + + P P T ++TSI ++W E + I
Sbjct: 570 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 629
Query: 356 IQHKPK-----NSEELYKEIDGVA--TTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 408
++ K ++ EI G+ TT+Y + L +++Y V A ++G GP S V
Sbjct: 630 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 689
Query: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKE--PEEPNGQIQGYRVYYT-MDPTQHVNN 465
L +T+E PS PR V+ ++ST++ V W+ P + +GQI+GY+V+Y M+ +
Sbjct: 690 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 749
Query: 466 WMKHNV--ADSQ----ITT-----IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTG 514
M +V AD+Q TT I L P+ +YS+ V A+T+ GDG S V T
Sbjct: 750 PMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA 809
Query: 515 VPGQPLNFKAEPESETSILLSWTPPRSDT---IANYELVYKDGEHGEEQRITI---EPGT 568
VPG+P + T+ L+ W PP DT + Y L K G E T+ E
Sbjct: 810 VPGKPRLVINHTQMNTA-LIQWHPP-VDTFGPLQGYRL--KFGRKDMEPLTTLEFSEKED 865
Query: 569 SYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEIS-ARTMQSMFAKNFHVKAVMKTSVLLS 626
+ + + Y FRL+AR+ G G EIS + + F +N H + TSV LS
Sbjct: 866 HFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLS 925
Query: 627 WEIP---ENYNSAMPFKILYDDGK-----MVEEVDGRATQKLIVNLKPEKSYSF-VLTNR 677
W+ P E + +LY D M + + T + LKP+ +Y V +
Sbjct: 926 WQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHT 985
Query: 678 GNSAGGLQHRVTAKTAP 694
G V +T P
Sbjct: 986 SKGPGPYSPSVQFRTLP 1002
Score = 102 bits (255), Expect = 2e-21
Identities = 135/598 (22%), Positives = 237/598 (39%), Gaps = 79/598 (13%)
Query: 143 ATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQ 202
A+ +C A+G+P P+I W K V +N R + + + G+ +R +Q ++ D+
Sbjct: 41 ASFICQATGDPRPKIVWNKKGKKV----SNQRFEVIEFDDGSGSVLR--IQPLRTPR-DE 93
Query: 203 GKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGS 262
YECVA+N+ G S L V ++ R P + P + + + C A G+
Sbjct: 94 AIYECVASNNVG-EISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGN 152
Query: 263 PMPYVKWMLGAEDLTPED---------DMPIGRNVLELNDVRQSANYTCVAMSTLGV--- 310
P P + W +D P D + G +E ++ Y CVA ++ G
Sbjct: 153 PDPEITWF---KDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECVATNSAGTRYS 209
Query: 311 IEAIAQITVKALPK----PPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHK---PKNS 363
A + V+ +P PP + + +IT G+P P +++ + P++
Sbjct: 210 APANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCV-AVGSPMPYVKWMLGAEDLTPEDD 268
Query: 364 EELYKEI----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSS 419
+ + + D + Y+ +S E PP PV+T+++
Sbjct: 269 MPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTEST------ 322
Query: 420 APRDVQARMLSSTTILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT 478
+T+I + W EP V Y + + N+ + D TT
Sbjct: 323 -----------ATSITLTWDSGNPEP--------VSYYIIQHKPKNSEELYKEIDGVATT 363
Query: 479 ---IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILL 534
+ L P Y +V+A +IG GP S + T P P + +A S T+IL+
Sbjct: 364 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 423
Query: 535 SWTPPRSDT--IANYELVYK--DGEHGEE-QRITIEPGTSYRLQGLKPNSLYYFRLAARS 589
W P I Y + Y +H + + + L P Y ++ A +
Sbjct: 424 QWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT 483
Query: 590 PQGLGASTAEISARTMQSMFAK--NFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGK 647
G G +++I T + + NF + +TS+LLSW P + ++ ++++Y DG+
Sbjct: 484 SIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRS-DTIANYELVYKDGE 542
Query: 648 MVEE---VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPA 702
EE T + LKP Y F L R G TA+ + +++KP+
Sbjct: 543 HGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAS---TAEISARTMQSKPS 597
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 1506 bits (3899), Expect = 0.0
Identities = 794/1270 (62%), Positives = 946/1270 (74%), Gaps = 46/1270 (3%)
Query: 271 LGAEDLTPED--DMPIGRNVLELNDVRQSANY--TCVAMSTLGVIEAIAQITVKA---LP 323
LG+ED P++ +P + L + + Y T VA + +G + + V+ +P
Sbjct: 648 LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 707
Query: 324 KPPGTPVVTES-TATSITLTWDSGNPE---------PVSYYIIQHKPKNSEELYKEIDGV 373
P V E+ AT+I + W S P V Y ++ K++
Sbjct: 708 SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 767
Query: 374 ATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTT 433
+ L P + Y V A G G S+P + T VQ S
Sbjct: 768 DAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGS-- 825
Query: 434 ILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKV 492
+L +W+ P Q+ GYR+ + + + + ++ ++ + T G + TY ++
Sbjct: 826 LLARWEPPAGTAEDQVLGYRLQFGREDSTPLAT-LEFPPSEDRYTASG-VHKGATYVFRL 883
Query: 493 LAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESET-SILLSWTPP----RSDTIANY 547
A + G G ++++ I + G P +A + ++LL W PP R+ I Y
Sbjct: 884 AARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKY 943
Query: 548 ELVYKD-GEHGEEQRITI----EPGT--SYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
+ ++ G G + + EPG + LQGLKP++ Y ++ A + +G G + +
Sbjct: 944 TVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPV 1003
Query: 601 SARTM--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQ 658
RT + KNF VK +MKTSVLLSWE P+NYNS P+KI Y+ + +VDGR T+
Sbjct: 1004 RYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTK 1061
Query: 659 KLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLP 718
KLI +LKP Y+FVLTNRG+S GGLQ VTA TA ++L KP+ K + DG I V LP
Sbjct: 1062 KLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLP 1121
Query: 719 EVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR-KRRSIRYGREVE 776
+ + ++ Y+I++VPL+KSRG +F+ P SP++M+L+EL+++ISR +RRS+R+ R++E
Sbjct: 1122 DGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLE 1181
Query: 777 L-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPY 835
+ +PYIAA F VLP F GD K YGGF N+ L+ G YV FVLAV++ +E +A SP+
Sbjct: 1182 VPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FAASPF 1240
Query: 836 SDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRK----RAESDSRKS 891
SDP + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK K R +S+ R
Sbjct: 1241 SDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTK 1300
Query: 892 SIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYE 951
+ NN ++ HHP DPVE+RR+NFQTPGM SHPPIPI ++A+H ERLKAND+LK SQEYE
Sbjct: 1301 CLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYE 1360
Query: 952 SIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQ 1011
SIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV+L IEGI GSDY+NANY+DGYR Q
Sbjct: 1361 SIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQ 1420
Query: 1012 NAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQV 1071
NAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QV
Sbjct: 1421 NAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQV 1480
Query: 1072 TLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCN 1131
TLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCN
Sbjct: 1481 TLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCN 1540
Query: 1132 PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1191
PPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY
Sbjct: 1541 PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQY 1600
Query: 1192 IFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFI 1251
FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFI
Sbjct: 1601 SFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFI 1660
Query: 1252 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1311
SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA
Sbjct: 1661 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1720
Query: 1312 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1371
ETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY
Sbjct: 1721 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1780
Query: 1372 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1431
ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV
Sbjct: 1781 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1840
Query: 1432 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE 1491
HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALE
Sbjct: 1841 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE 1900
Query: 1492 YLGSFDHYAT 1501
YLGSFDHYAT
Sbjct: 1901 YLGSFDHYAT 1910
Score = 883 bits (2282), Expect = 0.0
Identities = 455/741 (61%), Positives = 557/741 (75%), Gaps = 31/741 (4%)
Query: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
Query: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS GALQIE SEE
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS---------GALQIESSEE 199
Query: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
+DQGKYECVATNSAG RYS+PANLYVR VRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200 TDQGKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSILPMSHEIMPGGNVNITCVA 255
Query: 260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319
VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 256 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 315
Query: 320 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379
K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS
Sbjct: 316 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 375
Query: 380 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439
+ GLSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 376 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 435
Query: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
EP EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+G
Sbjct: 436 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 495
Query: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559
DGPLS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 496 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 555
Query: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFA---KNFHVK 616
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+QS + ++
Sbjct: 556 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 615
Query: 617 AVMKTSVLLSWE--IPENYNSAM-----PFKILYDDGKMVEEVDG---RATQKLIVNLKP 666
+V T++L+SW PE +N A+ ++ L + +EV+G TQ L+ L+
Sbjct: 616 SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 675
Query: 667 EKSYSFVLTNRGNSAGGLQHR-VTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA--- 722
Y G + V +T DV P + L+ L PA
Sbjct: 676 WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 735
Query: 723 -NENIKGYYIIIVPLKKSRGK 742
+ I+GY + V ++ + +
Sbjct: 736 QHGQIRGYQVHYVRMEGAEAR 756
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 1492 bits (3862), Expect = 0.0
Identities = 795/1295 (61%), Positives = 947/1295 (73%), Gaps = 71/1295 (5%)
Query: 271 LGAEDLTPED--DMPIGRNVLELNDVRQSANY--TCVAMSTLGVIEAIAQITVKA---LP 323
LG+ED P++ +P + L + + Y T VA + +G + + V+ +P
Sbjct: 661 LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 720
Query: 324 KPPGTPVVTES-TATSITLTWDSGNPE---------PVSYYIIQHKPKNSEELYKEI--- 370
P V E+ AT+I + W S P V Y ++ K++
Sbjct: 721 SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 780
Query: 371 ------DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 424
D A + L P + Y V A G G S+P + T V
Sbjct: 781 DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 840
Query: 425 QARMLSSTTILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 483
Q S +L +W+ P Q+ GYR+ + + + + ++ ++ + T G +
Sbjct: 841 QQTPEGS--LLARWEPPAGTAEDQVLGYRLQFGREDSTPLAT-LEFPPSEDRYTASG-VH 896
Query: 484 PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESET-SILLSWTPP--- 539
TY ++ A + G G ++++ I + G P +A + ++LL W PP
Sbjct: 897 KGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPA 956
Query: 540 -RSDTIANYELVYKD-GEHGEEQRITI----EPGT--SYRLQGLKPNSLYYFRLAARSPQ 591
R+ I Y + ++ G G + + EPG + LQGLKP++ Y ++ A + +
Sbjct: 957 ERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRR 1016
Query: 592 GLGASTAEISARTM--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMV 649
G G + + RT + KNF VK +MKTSVLLSWE P+NYNS P+KI Y+ +
Sbjct: 1017 GPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG--LT 1074
Query: 650 EEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL 709
+VDGR T+KLI +LKP Y+FVLTNRG+S GGLQ VTA TA ++L KP+ K +
Sbjct: 1075 LDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDA 1134
Query: 710 DGMITVQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR-KRR 767
DG I V LP+ + ++ Y+I++VPL+KSRG +F+ P SP++M+L+EL+++ISR +RR
Sbjct: 1135 DGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRR 1194
Query: 768 SIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAE 826
S+R+ R++E+ +PYIAA F VLP F GD K YGGF N+ L+ G YV FVLAV++ +E
Sbjct: 1195 SLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSE 1254
Query: 827 SKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRK---- 882
+A SP+SDP + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK K
Sbjct: 1255 PT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSK 1313
Query: 883 RAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTP----------------GMASHPPI 926
R +S+ R + NN ++ HHP DPVE+RR+NFQTP M SHPPI
Sbjct: 1314 RKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPI 1373
Query: 927 PILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV 986
PI ++A+H ERLKAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV
Sbjct: 1374 PIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV 1433
Query: 987 LLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKL 1046
+L IEGI GSDY+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+L
Sbjct: 1434 ILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRL 1493
Query: 1047 EERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFT 1106
EE+SR+KCDQYWP+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFT
Sbjct: 1494 EEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFT 1553
Query: 1107 AWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEK 1166
AWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EK
Sbjct: 1554 AWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEK 1613
Query: 1167 TVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIET 1226
TVD+YGHVTLMR+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E
Sbjct: 1614 TVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEP 1673
Query: 1227 GENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS 1286
GE+VTGMELEFKRLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS
Sbjct: 1674 GEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS 1733
Query: 1287 DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQY 1346
DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQY
Sbjct: 1734 DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQY 1793
Query: 1347 WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSG 1406
WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSG
Sbjct: 1794 WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSG 1853
Query: 1407 EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK 1466
EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK
Sbjct: 1854 EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK 1913
Query: 1467 MLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1501
MLRTQRPAMVQTED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1914 MLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1948
Score = 914 bits (2362), Expect = 0.0
Identities = 472/771 (61%), Positives = 580/771 (75%), Gaps = 28/771 (3%)
Query: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
Query: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRSE+ TPIRGALQIE SEE
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEE 208
Query: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
+DQGKYECVATNSAG RYS+PANLYVRELREVRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 209 TDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVA 268
Query: 260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319
VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 269 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 328
Query: 320 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379
K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS
Sbjct: 329 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 388
Query: 380 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439
+ GLSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 389 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 448
Query: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
EP EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+G
Sbjct: 449 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 508
Query: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559
DGPLS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 509 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 568
Query: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFA---KNFHVK 616
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+QS + ++
Sbjct: 569 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 628
Query: 617 AVMKTSVLLSWE--IPENYNSAM-----PFKILYDDGKMVEEVDG---RATQKLIVNLKP 666
+V T++L+SW PE +N A+ ++ L + +EV+G TQ L+ L+
Sbjct: 629 SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 688
Query: 667 EKSYSFVLTNRGNSAGGLQHR-VTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA--- 722
Y G + V +T DV P + L+ L PA
Sbjct: 689 WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 748
Query: 723 -NENIKGYYIIIVPLK--KSRG-KFIK-------PWESPDEMELDELLKEI 762
+ I+GY + V ++ ++RG IK WE+ D E + ++ +
Sbjct: 749 QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNL 799
Score = 136 bits (342), Expect = 2e-31
Identities = 181/779 (23%), Positives = 298/779 (38%), Gaps = 125/779 (16%)
Query: 16 LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75
LR PRF+ P+ + GG + C A G P P + W Q E + +
Sbjct: 237 LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 288
Query: 76 DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135
D + L +D A Y CVA +++G I ++TV + P G P
Sbjct: 289 DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 339
Query: 136 VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIE 195
V E T T+ + SGNPDP ++++ IE
Sbjct: 340 VTENTATSITITWDSGNPDP-VSYY--------------------------------VIE 366
Query: 196 QSEESDQGKYECVATNSAGTRYS-------APANLYVRELREVRRVPPRFSIPPTNHEIM 248
+S G Y+ + + TRYS + ++V + + + PP S+ E
Sbjct: 367 YKSKSQDGPYQ-IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQA 425
Query: 249 PGGSV-NITCVAVGSPMPYVKWMLGAED----------LTPEDDMPIG----RNV----- 288
P + N+ + + V+W E T E + P+G NV
Sbjct: 426 PASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLL 485
Query: 289 LELNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTW 343
+ + + YT +A +++G I VK PG P+ + A TSITL+W
Sbjct: 486 TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSW 545
Query: 344 DSGNPEP-VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRG 402
E + Y ++ + + E+ + D TT Y V L P ++Y FR+ A + G G
Sbjct: 546 SPPRQESIIKYELLFREGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLG 603
Query: 403 PPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYY----T 456
+ V +T + PS+ P+DV+ + ST ILV W+ PE NG + GY V Y +
Sbjct: 604 AFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGS 663
Query: 457 MDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP 516
DP N + + L Y + +A T +G GP SS + V T VP
Sbjct: 664 EDPEPKEVNGIPPTTTQILLEA---LEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 720
Query: 517 -GQPLNFKAEPESETSILLSWTPP----RSDTIANYELVYKDGEHGE------------- 558
P +AE + T+I + W P + I Y++ Y E E
Sbjct: 721 SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 780
Query: 559 EQRITIEPGTSYR--LQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAK-NFHV 615
+ + + Y + L+P + Y +AA + +G GA + T ++ + V
Sbjct: 781 DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 840
Query: 616 KAVMKTSVLLSWEIPEN--YNSAMPFKILY--DDGKMVEEVDGRATQKLIVNLKPEKSYS 671
+ + S+L WE P + + +++ + +D + ++ ++ K +
Sbjct: 841 QQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGAT 900
Query: 672 FVLTNRGNSAGGLQHRV--TAKTAPDVLRTKPAFI---GKTNLDGMITVQLPEVPANEN 725
+V S GGL D R P + G + ++ LP VPA N
Sbjct: 901 YVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERN 959
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 1451 bits (3755), Expect = 0.0
Identities = 758/1199 (63%), Positives = 893/1199 (74%), Gaps = 33/1199 (2%)
Query: 325 PPGTPVVTESTATSITLTWDSGNPEP---------VSYYIIQHKPKNSEELYKEIDGVAT 375
PP V +T++ + W P V+Y +++ + +++
Sbjct: 711 PPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEA 770
Query: 376 TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTIL 435
+++GL+P + Y V A G G S+P + T+ P + ++ T L
Sbjct: 771 QETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMN--TAL 828
Query: 436 VQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAF 495
+QW P+E G++ GYR+ Y N D Q T+ L TY ++ A
Sbjct: 829 LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGK--DDQHFTVTGLHKGTTYIFRLAAK 886
Query: 496 TSIGDGPLSSDIQVITQTGVP-GQPLNFKAEPESETSILLSWTPP----RSDTIANYELV 550
G G + ++ T +P G P N + ++ L+W PP R+ I +Y +V
Sbjct: 887 NRAGLGE-EFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVV 945
Query: 551 YKDGEHGEE-QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTM--QS 607
++D +E Q IT + T + L GLKP++ Y ++ A + +G G + I +RTM +
Sbjct: 946 FRDINSQQELQNITTD--TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQ 1003
Query: 608 MFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPE 667
+FAKNF V A MKTSVLLSWE+P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P
Sbjct: 1004 VFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPN 1061
Query: 668 KSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIK 727
YSFVL NRG+SAGGLQH V+ +TAPD+L KP DG + +P V ++
Sbjct: 1062 TEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVR 1121
Query: 728 GYYIIIVPLKKSRGKFIKP-WESPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAH 784
+YI++VP+ + G + P W +P+E+ELDELL+ I + R R LKPY+AA
Sbjct: 1122 WFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQ 1181
Query: 785 FDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMD 843
DVLP FTLGD K+Y GF N+ L Y FVLA + E + K YA+SPYSD +V
Sbjct: 1182 LDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQV 1241
Query: 844 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSH 902
Q EE ++WV GPVLAV+ II IVIAILL+KRKR S S K K+
Sbjct: 1242 TPAQQ--QEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLA 1299
Query: 903 HPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWE 962
H +DPVE+RRLN+QTPGM HPPIPI +LAD+IERLKAND LKFSQEYESIDPGQQFTWE
Sbjct: 1300 HSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWE 1359
Query: 963 HSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP 1022
+SNLEVNKPKNRYANVIAYDHSRV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG LP
Sbjct: 1360 NSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLP 1419
Query: 1023 ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATY 1082
ET GDFWRM+WEQR+ATVVMMT+LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVELATY
Sbjct: 1420 ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATY 1479
Query: 1083 CVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHC 1142
VRTFAL+K+GSSEKRE+RQFQF AWPDHGVPE+PTP LAFLRRVK CNP DAGPMVVHC
Sbjct: 1480 TVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHC 1539
Query: 1143 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1202
SAGVGRTGCFIVIDAMLER+KHEKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALLEA
Sbjct: 1540 SAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA 1599
Query: 1203 TCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKN 1262
TCG+TEVPARNLYA+IQKL Q+ GE+VT MELEFK LASSKAHTSRFISANLPCNKFKN
Sbjct: 1600 TCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKN 1659
Query: 1263 RLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLW 1322
RLVNIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLW
Sbjct: 1660 RLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLW 1719
Query: 1323 EHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR 1382
EHNSTI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR
Sbjct: 1720 EHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR 1779
Query: 1383 DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGV 1442
DGQSRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGV
Sbjct: 1780 DGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGV 1839
Query: 1443 FITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1501
FITLSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTEDQYQ YRAALEYLGSFDHYAT
Sbjct: 1840 FITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1898
Score = 804 bits (2077), Expect = 0.0
Identities = 404/626 (64%), Positives = 496/626 (79%), Gaps = 17/626 (2%)
Query: 9 LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68
L++L ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 18 LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77
Query: 69 FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128
FEVIEFDDG+GSVLRIQPLR RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 78 FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137
Query: 129 DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPI 188
DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRS
Sbjct: 138 DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRS-------- 189
Query: 189 RGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIM 248
GALQIE SEESDQGKYECVATNSAGTRYSAPANLYVR VRRV PRFSIPP++ E+M
Sbjct: 190 -GALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSIPPSSQEVM 244
Query: 249 PGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL 308
PGGSVN+TCVAVG+PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+L
Sbjct: 245 PGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL 304
Query: 309 GVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYK 368
G+IEA AQ+TVKALPKPP VVTE+TATS+TLTWDSGN EPV+YY IQ++ +E ++
Sbjct: 305 GMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQ 364
Query: 369 EIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARM 428
E+DGVATTRYS+ GLSP+S+Y FRV+AVN+IGRGPPSE V +T EQAPSS PR VQARM
Sbjct: 365 EVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARM 424
Query: 429 LSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTY 488
LS++T+LVQW+ PEEPNG ++GYRVYYT D + N W KHN +TT+G+L+P TY
Sbjct: 425 LSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITY 484
Query: 489 SVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYE 548
S++VLAFT++GDGP S IQV TQ GVP QP +F+AE ES+T I LSW P + I YE
Sbjct: 485 SLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYE 544
Query: 549 LVYKDGEHGEEQ-RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607
LVY E ++Q ++T +P +SY L+ LKP++LY F+LAARS G+G T I ART QS
Sbjct: 545 LVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQS 604
Query: 608 MFA---KNFHVKAVMKTSVLLSWEIP 630
+ + ++ T+V +SW P
Sbjct: 605 TPSAPPQKVMCVSMGSTTVRVSWVPP 630
Score = 147 bits (371), Expect = 8e-35
Identities = 121/425 (28%), Positives = 196/425 (46%), Gaps = 34/425 (8%)
Query: 300 YTCVAMSTLGV---IEAIAQITVKALPKPPGTPVVTEST-ATSITLTW-----DSGNPEP 350
+ A S +GV I T ++ P P V+ S +T++ ++W DS N
Sbjct: 580 FQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVI 639
Query: 351 VSYYIIQHKPKNSEELYKEIDGVAT--TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 408
Y + + +DG++ + + + GL +++Y V A ++G GP S PV
Sbjct: 640 TQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPV 699
Query: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYYTM---DPTQHV 463
L +T E PS PR V+ L+ST + V WK P + +GQI+GY+V Y + +
Sbjct: 700 LVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGL 759
Query: 464 NNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK 523
+A++Q TTI L P+ TYSV V A+T+ GDG S V T VPG+P
Sbjct: 760 PIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMI 819
Query: 524 AEPESETSILLSWTPPRS--DTIANYELVYKDGEHGEEQRITI-EPGTSYRLQGLKPNSL 580
+ T+ LL W PP+ + Y L Y + I + + + GL +
Sbjct: 820 STTAMNTA-LLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTT 878
Query: 581 YYFRLAARSPQGLGASTAEISART---MQSMFAKNFHVKAVMKTSVLLSWEIP---ENYN 634
Y FRLAA++ GLG E RT + S F +N HV + ++ L+W+ P E
Sbjct: 879 YIFRLAAKNRAGLG-EEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNG 937
Query: 635 SAMPFKILYDDGKMVEEVDGRATQK--LIVNLKPEKSYSFVL---TNRGNSAGGLQHRVT 689
+ + +++ D +E+ T + LKP+ +Y + T++G +G L +
Sbjct: 938 RIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKG--SGPLSPSIQ 995
Query: 690 AKTAP 694
++T P
Sbjct: 996 SRTMP 1000
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 1449 bits (3751), Expect = 0.0
Identities = 750/1136 (66%), Positives = 873/1136 (76%), Gaps = 24/1136 (2%)
Query: 379 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438
+++GL+P + Y V A G G S+P + T+ P + ++ T L+QW
Sbjct: 783 TISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMN--TALLQW 840
Query: 439 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 498
P+E G++ GYR+ Y N D Q T+ L TY ++ A
Sbjct: 841 HPPKELPGELLGYRLQYCRADEARPNTIDFGK--DDQHFTVTGLHKGTTYIFRLAAKNRA 898
Query: 499 GDGPLSSDIQVITQTGVP-GQPLNFKAEPESETSILLSWTPP----RSDTIANYELVYKD 553
G G + ++ T +P G P N + ++ L+W PP R+ I +Y +V++D
Sbjct: 899 GLGE-EFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD 957
Query: 554 GEHGEE-QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTM--QSMFA 610
+E Q IT + T + L GLKP++ Y ++ A + +G G + I +RTM + +FA
Sbjct: 958 INSQQELQNITTD--TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFA 1015
Query: 611 KNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSY 670
KNF V A MKTSVLLSWE+P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P Y
Sbjct: 1016 KNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPNTEY 1073
Query: 671 SFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYY 730
SFVL NRG+SAGGLQH V+ +TAPD+L KP DG + +P V ++ +Y
Sbjct: 1074 SFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFY 1133
Query: 731 IIIVPLKKSRGKFIKP-WESPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAHFDV 787
I++VP+ + G + P W +P+E+ELDELL+ I + R R LKPY+AA DV
Sbjct: 1134 IVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDV 1193
Query: 788 LPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMDLDP 846
LP FTLGD K+Y GF N+ L Y FVLA + E + K YA+SPYSD +V
Sbjct: 1194 LPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPA 1253
Query: 847 QPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPT 905
Q EE ++WV GPVLAV+ II IVIAILL+KRKR S S K K+ H +
Sbjct: 1254 QQ--QEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSS 1311
Query: 906 DPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSN 965
DPVE+RRLN+QTPGM HPPIPI +LAD+IERLKAND LKFSQEYESIDPGQQFTWE+SN
Sbjct: 1312 DPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSN 1371
Query: 966 LEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETF 1025
LEVNKPKNRYANVIAYDHSRV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG LPET
Sbjct: 1372 LEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETM 1431
Query: 1026 GDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVR 1085
GDFWRM+WEQR+ATVVMMT+LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVELATY VR
Sbjct: 1432 GDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVR 1491
Query: 1086 TFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAG 1145
TFAL+K+GSSEKRE+RQFQF AWPDHGVPE+PTP LAFLRRVK CNP DAGPMVVHCSAG
Sbjct: 1492 TFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAG 1551
Query: 1146 VGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCG 1205
VGRTGCFIVIDAMLER+KHEKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALLEA TCG
Sbjct: 1552 VGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCG 1611
Query: 1206 NTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLV 1265
+TEVPARNLYA+IQKL Q+ GE+VT MELEFK LASSKAHTSRFISANLPCNKFKNRLV
Sbjct: 1612 HTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLV 1671
Query: 1266 NIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHN 1325
NIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWEHN
Sbjct: 1672 NIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHN 1731
Query: 1326 STIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ 1385
STI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ
Sbjct: 1732 STIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ 1791
Query: 1386 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFIT 1445
SRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVFIT
Sbjct: 1792 SRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFIT 1851
Query: 1446 LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1501
LSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTEDQYQ YRAALEYLGSFDHYAT
Sbjct: 1852 LSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1907
Score = 804 bits (2077), Expect = 0.0
Identities = 404/626 (64%), Positives = 496/626 (79%), Gaps = 17/626 (2%)
Query: 9 LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68
L++L ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 18 LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77
Query: 69 FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128
FEVIEFDDG+GSVLRIQPLR RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 78 FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137
Query: 129 DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPI 188
DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRS
Sbjct: 138 DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRS-------- 189
Query: 189 RGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIM 248
GALQIE SEESDQGKYECVATNSAGTRYSAPANLYVR VRRV PRFSIPP++ E+M
Sbjct: 190 -GALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSIPPSSQEVM 244
Query: 249 PGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL 308
PGGSVN+TCVAVG+PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+L
Sbjct: 245 PGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL 304
Query: 309 GVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYK 368
G+IEA AQ+TVKALPKPP VVTE+TATS+TLTWDSGN EPV+YY IQ++ +E ++
Sbjct: 305 GMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQ 364
Query: 369 EIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARM 428
E+DGVATTRYS+ GLSP+S+Y FRV+AVN+IGRGPPSE V +T EQAPSS PR VQARM
Sbjct: 365 EVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARM 424
Query: 429 LSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTY 488
LS++T+LVQW+ PEEPNG ++GYRVYYT D + N W KHN +TT+G+L+P TY
Sbjct: 425 LSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITY 484
Query: 489 SVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYE 548
S++VLAFT++GDGP S IQV TQ GVP QP +F+AE ES+T I LSW P + I YE
Sbjct: 485 SLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYE 544
Query: 549 LVYKDGEHGEEQ-RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607
LVY E ++Q ++T +P +SY L+ LKP++LY F+LAARS G+G T I ART QS
Sbjct: 545 LVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQS 604
Query: 608 MFA---KNFHVKAVMKTSVLLSWEIP 630
+ + ++ T+V +SW P
Sbjct: 605 TPSAPPQKVMCVSMGSTTVRVSWVPP 630
Score = 144 bits (364), Expect = 5e-34
Identities = 122/435 (28%), Positives = 193/435 (44%), Gaps = 45/435 (10%)
Query: 300 YTCVAMSTLGV---IEAIAQITVKALPKPPGTPVVTEST-ATSITLTW-----DSGNPEP 350
+ A S +GV I T ++ P P V+ S +T++ ++W DS N
Sbjct: 580 FQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVI 639
Query: 351 VSYYIIQHKPKNSEELYKEIDGVAT--TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 408
Y + + +DG++ + + + GL +++Y V A ++G GP S PV
Sbjct: 640 TQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPV 699
Query: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYYT---------- 456
L +T E PS PR V+ L+ST + V WK P + +GQI+GY+V Y
Sbjct: 700 LVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGL 759
Query: 457 ---MDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQT 513
D W D + TTI L P+ TYSV V A+T+ GDG S V T
Sbjct: 760 PIIQDVMLAEAQWRPEESEDYE-TTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTG 818
Query: 514 GVPGQPLNFKAEPESETSILLSWTPPRS--DTIANYELVYKDGEHGEEQRITI-EPGTSY 570
VPG+P + T+ LL W PP+ + Y L Y + I + +
Sbjct: 819 AVPGRPTMMISTTAMNTA-LLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHF 877
Query: 571 RLQGLKPNSLYYFRLAARSPQGLGASTAEISART---MQSMFAKNFHVKAVMKTSVLLSW 627
+ GL + Y FRLAA++ GLG E RT + S F +N HV + ++ L+W
Sbjct: 878 TVTGLHKGTTYIFRLAAKNRAGLG-EEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAW 936
Query: 628 EIP---ENYNSAMPFKILYDDGKMVEEVDGRATQK--LIVNLKPEKSYSFVL---TNRGN 679
+ P E + + +++ D +E+ T + LKP+ +Y + T++G
Sbjct: 937 DPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKG- 995
Query: 680 SAGGLQHRVTAKTAP 694
+G L + ++T P
Sbjct: 996 -SGPLSPSIQSRTMP 1009
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 602 bits (1552), Expect = e-172
Identities = 312/681 (45%), Positives = 431/681 (63%), Gaps = 13/681 (1%)
Query: 827 SKMYATSPYSDPVVSMDLDPQPITDEEE--GLIWVVGPVLAVVFIICIVIAILLYKRKRA 884
S AT+P + P S + D + DE ++ + +L +VFII ++ + K K+A
Sbjct: 125 SSTAATTPETFPP-SGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQA 183
Query: 885 ESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNL 944
S S + N + +P + L +PP+P+ +L + I R A+DN
Sbjct: 184 GSHSNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNK 239
Query: 945 KFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNAN 1003
F +E+ ++ Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA+
Sbjct: 240 LFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINAS 299
Query: 1004 YIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGT 1063
+I+GY+++N +IA QG ET DFWRMIWEQ +AT+VM+T L+ER KC QYWP +G
Sbjct: 300 FINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGC 359
Query: 1064 ETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTP 1119
T+G ++V++ D L Y VR F + + G R+ + QF FT+WPD GVP P
Sbjct: 360 WTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIG 419
Query: 1120 FLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRA 1179
L FL++VK CNP AG +VVHCSAGVGRTG F+VIDAML+ + E+ VD+YG V+ +RA
Sbjct: 420 MLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRA 479
Query: 1180 QRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKR 1239
QR MVQT+ QY+FI+ ALLE G+TE+ +L ++QK+ G + G+E EFK+
Sbjct: 480 QRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKK 539
Query: 1240 LASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQ 1299
L S K + + NLP N KNR++ I+PYE RV + RG E +DY+NASFIDGYRQ
Sbjct: 540 LTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQ 599
Query: 1300 QKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFV 1359
+ +YIA+QGPL T EDFWRM+WE S +VMLT+L E G+EKC QYWP++ Y
Sbjct: 600 KDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDIT 659
Query: 1360 VDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKT 1419
V+ E Y +R+ VT+ R+ +SR +RQF F WPE G+P G+G I I V K
Sbjct: 660 VELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQ 719
Query: 1420 KEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTE 1479
++Q G + PI+VHCSAG GRTG F LS VLER++ EG++D+FQTVK LR QRP MVQT
Sbjct: 720 QQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTL 778
Query: 1480 DQYQFSYRAALEYLGSFDHYA 1500
+QY+F Y+ EY+ +F YA
Sbjct: 779 EQYEFCYKVVQEYIDAFSDYA 799
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 601 bits (1550), Expect = e-171
Identities = 311/679 (45%), Positives = 428/679 (63%), Gaps = 18/679 (2%)
Query: 827 SKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAES 886
S AT+P + P D PI ++ + +L +VFII ++ + K K+A S
Sbjct: 125 SSTAATTPETFP----PSDETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGS 176
Query: 887 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 946
S + N + +P + L +PP+P+ +L + I R A+DN F
Sbjct: 177 HSNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLF 232
Query: 947 SQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYI 1005
+E+ ++ Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA++I
Sbjct: 233 REEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFI 292
Query: 1006 DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTET 1065
+GY+++N +IA QG ET DFWRMIWEQ +AT+VM+T L+ER KC QYWP +G T
Sbjct: 293 NGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWT 352
Query: 1066 HGLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFL 1121
+G ++V++ D L Y VR F + + G R+ + QF FT+WPD GVP P L
Sbjct: 353 YGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGML 412
Query: 1122 AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQR 1181
FL++VK CNP AG +VVHCSAGVGRTG F+VIDAML+ + E+ VD+YG V+ +RAQR
Sbjct: 413 KFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQR 472
Query: 1182 NYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLA 1241
MVQT+ QY+FI+ ALLE G+TE+ +L ++QK+ G + G+E EFK+L
Sbjct: 473 CQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLT 532
Query: 1242 SSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQK 1301
S K + + NLP N KNR++ I+PYE RV + RG E +DY+NASFIDGYRQ+
Sbjct: 533 SIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKD 592
Query: 1302 AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVD 1361
+YIA+QGPL T EDFWRM+WE S +VMLT+L E G+EKC QYWP++ Y V+
Sbjct: 593 SYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVE 652
Query: 1362 PMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKE 1421
E Y +R+ VT+ R+ +SR +RQF F WPE G+P G+G I I V K ++
Sbjct: 653 LKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQ 712
Query: 1422 QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQ 1481
Q G + PI+VHCSAG GRTG F LS VLER++ EG++D+FQTVK LR QRP MVQT +Q
Sbjct: 713 QSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771
Query: 1482 YQFSYRAALEYLGSFDHYA 1500
Y+F Y+ EY+ +F YA
Sbjct: 772 YEFCYKVVQEYIDAFSDYA 790
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 601 bits (1550), Expect = e-171
Identities = 311/679 (45%), Positives = 428/679 (63%), Gaps = 18/679 (2%)
Query: 827 SKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAES 886
S AT+P + P D PI ++ + +L +VFII ++ + K K+A S
Sbjct: 125 SSTAATTPETFP----PSDETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGS 176
Query: 887 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 946
S + N + +P + L +PP+P+ +L + I R A+DN F
Sbjct: 177 HSNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLF 232
Query: 947 SQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYI 1005
+E+ ++ Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA++I
Sbjct: 233 REEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFI 292
Query: 1006 DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTET 1065
+GY+++N +IA QG ET DFWRMIWEQ +AT+VM+T L+ER KC QYWP +G T
Sbjct: 293 NGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWT 352
Query: 1066 HGLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFL 1121
+G ++V++ D L Y VR F + + G R+ + QF FT+WPD GVP P L
Sbjct: 353 YGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGML 412
Query: 1122 AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQR 1181
FL++VK CNP AG +VVHCSAGVGRTG F+VIDAML+ + E+ VD+YG V+ +RAQR
Sbjct: 413 KFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQR 472
Query: 1182 NYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLA 1241
MVQT+ QY+FI+ ALLE G+TE+ +L ++QK+ G + G+E EFK+L
Sbjct: 473 CQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLT 532
Query: 1242 SSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQK 1301
S K + + NLP N KNR++ I+PYE RV + RG E +DY+NASFIDGYRQ+
Sbjct: 533 SIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKD 592
Query: 1302 AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVD 1361
+YIA+QGPL T EDFWRM+WE S +VMLT+L E G+EKC QYWP++ Y V+
Sbjct: 593 SYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVE 652
Query: 1362 PMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKE 1421
E Y +R+ VT+ R+ +SR +RQF F WPE G+P G+G I I V K ++
Sbjct: 653 LKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQ 712
Query: 1422 QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQ 1481
Q G + PI+VHCSAG GRTG F LS VLER++ EG++D+FQTVK LR QRP MVQT +Q
Sbjct: 713 QSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771
Query: 1482 YQFSYRAALEYLGSFDHYA 1500
Y+F Y+ EY+ +F YA
Sbjct: 772 YEFCYKVVQEYIDAFSDYA 790
>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
precursor [Homo sapiens]
Length = 700
Score = 556 bits (1433), Expect = e-158
Identities = 294/655 (44%), Positives = 411/655 (62%), Gaps = 15/655 (2%)
Query: 856 LIWVVGPVLAVVFIICIVIAILLYKRKR-AESDSRKSSIPNNKEIPSHHPTDPVELRRLN 914
L W++ P+L ++ ++ + ++++R A + +PN I V L L+
Sbjct: 48 LAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKMPNG--ILEEQEQQRVML--LS 103
Query: 915 FQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKN 973
G + PIP+ L + I A+D +F +E+ S+ G Q T+E +N E N+ KN
Sbjct: 104 RSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKN 163
Query: 974 RYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIW 1033
RY N++ DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG ET DFWRM+W
Sbjct: 164 RYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVW 223
Query: 1034 EQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK-- 1091
EQ+SAT+VM+T L+ER KC QYWP +G T+G ++V + D V L Y +R F +
Sbjct: 224 EQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQL 283
Query: 1092 -NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1150
+G R V Q FT+WPD GVP P L FL++VKT NP AGP+VVHCSAGVGRTG
Sbjct: 284 PDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTG 343
Query: 1151 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVP 1210
FIVIDAM+ + E+ VD++ V+ +R QR MVQT+ QY FI+ ALLE G+TE+
Sbjct: 344 TFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELD 403
Query: 1211 ARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPY 1270
+L ++Q + T + G+E EF++L + + + NLP N K R++ I+PY
Sbjct: 404 VSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPY 463
Query: 1271 ESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVV 1330
+ RV L RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +V
Sbjct: 464 DFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIV 523
Query: 1331 MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQ 1385
MLT+++E ++KC+QYWP E S + ++ + +R+F VT ++ Q
Sbjct: 524 MLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQ 583
Query: 1386 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFIT 1445
R VRQF F WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI
Sbjct: 584 VRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIA 642
Query: 1446 LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1500
LS +LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+ +++ F YA
Sbjct: 643 LSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 697
>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
[Homo sapiens]
Length = 642
Score = 550 bits (1416), Expect = e-156
Identities = 282/591 (47%), Positives = 384/591 (64%), Gaps = 10/591 (1%)
Query: 919 GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYAN 977
G + PIP+ L + I A+D +F +E+ S+ G Q T+E +N E N+ KNRY N
Sbjct: 50 GPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPN 109
Query: 978 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1037
++ DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG ET DFWRM+WEQ+S
Sbjct: 110 ILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKS 169
Query: 1038 ATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK---NGS 1094
AT+VM+T L+ER KC QYWP +G T+G ++V + D V L Y +R F + +G
Sbjct: 170 ATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGC 229
Query: 1095 SEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIV 1154
R V Q FT+WPD GVP P L FL++VKT NP AGP+VVHCSAGVGRTG FIV
Sbjct: 230 KAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIV 289
Query: 1155 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNL 1214
IDAM+ + E+ VD++ V+ +R QR MVQT+ QY FI+ ALLE G+TE+ +L
Sbjct: 290 IDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSL 349
Query: 1215 YAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTR 1274
++Q + T + G+E EF++L + + + NLP N K R++ I+PY+ R
Sbjct: 350 EKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNR 409
Query: 1275 VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK 1334
V L RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +VMLT+
Sbjct: 410 VILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTE 469
Query: 1335 LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTV 1389
++E ++KC+QYWP E S + ++ + +R+F VT ++ Q R V
Sbjct: 470 VQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVV 529
Query: 1390 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1449
RQF F WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI LS +
Sbjct: 530 RQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNI 588
Query: 1450 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1500
LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+ +++ F YA
Sbjct: 589 LERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 510 bits (1313), Expect = e-144
Identities = 383/1236 (30%), Positives = 582/1236 (47%), Gaps = 165/1236 (13%)
Query: 379 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438
SVA + S ++R V ++ G G + L P + P L + W
Sbjct: 253 SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306
Query: 439 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 496
+P + G + ++ W + ++ DS + +L P Y ++VL
Sbjct: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366
Query: 497 SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 547
G GP + T+ P P N + + L W P + Y
Sbjct: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426
Query: 548 ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI------- 600
+ V+ ++ E+ I+ + Y L+GL+P RL +P+G S +
Sbjct: 427 QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDV 484
Query: 601 -SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA-- 656
A ++S+ F K + + W+ P N + ++I Y K V +D A
Sbjct: 485 PGAVPLESIQGGPFEEK------IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADL 535
Query: 657 -------------TQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPA 702
T L V L P +YSF + + ++A G VT + A + + P
Sbjct: 536 SSQRGKVFKLRNETHHLFVGLYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPE 593
Query: 703 FIGKTNL---DGMITVQLPEVPANENIKGYYIIIVP---LKKSRGK------FIKPWESP 750
+ T L D ITV L + Y ++V L+KSR F P
Sbjct: 594 YDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
Query: 751 DEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQS 810
+ LD L + ELKP A+ V FT+GD+K Y G+ N L
Sbjct: 654 NASSLDSL------------HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSP 697
Query: 811 GQEY-VFFVLAVMEHAESKMYAT---SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAV 866
+ Y ++F + E+K+ + + S ++P+ D + V+ +L
Sbjct: 698 LKSYSIYFQALSKANGETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLL-- 755
Query: 867 VFIICIVIAILLYKRKR-------------------------------AESDSRKSSIPN 895
+FII ++ +L KR+R A+ + K S
Sbjct: 756 MFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASR 815
Query: 896 NKE--------------------------IPSH--HPTDPVELRRLNFQTPGMASHPPIP 927
N E I +H DPVE+ P P I
Sbjct: 816 NDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIR 870
Query: 928 ILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVL 987
+ +L HI ++K F +EYE++ GQ +W+ + + N+ KNRY N+I+YDHSRV
Sbjct: 871 VADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVR 930
Query: 988 LSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLE 1047
L ++G P SDY+NANYIDGY + YIATQG + ET DFWRMIW++ SA++VM+T L
Sbjct: 931 LLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLV 990
Query: 1048 ERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTA 1107
E RVKC +YWP TE +G ++VTL++T LA Y +RTF + K G E RE+R F FT+
Sbjct: 991 EVGRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTS 1049
Query: 1108 WPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKT 1167
WPDHGVP + T L F+R+VK NPP+AGP+VVHCSAG GRTGCFI ID ML+ ++E
Sbjct: 1050 WPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGV 1109
Query: 1168 VDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA---RNLYAYIQKLTQI 1224
VDI+ V +RAQR +VQTE+QY+F+HDA+LEA CGNT +P R+LY I +L
Sbjct: 1110 VDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDP- 1168
Query: 1225 ETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVE 1284
+T + E + + + + LP N KNR ++++P + L + G E
Sbjct: 1169 QTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-E 1227
Query: 1285 GSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCH 1344
S+YINA+ +D ++Q A++ TQ PL T DFWR+++++N + VVML ++ + C
Sbjct: 1228 SSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCM 1285
Query: 1345 QYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QG 1401
QYWP + S Y V+ ++ I R F++ + Q R V+ Q+ WP +
Sbjct: 1286 QYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRD 1345
Query: 1402 VPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVD 1460
P S + + ++ K +EQ+ G++G VHC G GR+G F + V E ++ + ++D
Sbjct: 1346 TPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIID 1405
Query: 1461 IFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF 1496
+F VK LR + MV+T +QY+F Y ALEYL SF
Sbjct: 1406 VFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1441
Score = 68.9 bits (167), Expect = 3e-11
Identities = 82/325 (25%), Positives = 133/325 (40%), Gaps = 34/325 (10%)
Query: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 351
R + Y CV S G + A++ VK P P P E A T W N +
Sbjct: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316
Query: 352 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 407
+ + + + + + E V + Y + L P +YE RV+ G GPP P
Sbjct: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376
Query: 408 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 466
+ T+T P P++V+ + + + +QW EP G + Y Q+V N
Sbjct: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432
Query: 467 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 520
++ + S T+ L P T +++L S +G + S+ V+ T+ VPG PL
Sbjct: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490
Query: 521 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 573
E I + W PP + I YE+ YK G ++ + G ++L+
Sbjct: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550
Query: 574 ----GLKPNSLYYFRLAARSPQGLG 594
GL P + Y F + A + +G G
Sbjct: 551 HLFVGLYPGTTYSFTIKASTAKGFG 575
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 509 bits (1312), Expect = e-144
Identities = 302/766 (39%), Positives = 431/766 (56%), Gaps = 67/766 (8%)
Query: 789 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 843
P FT+GD++ Y GF N L + Y ++F E+K AT + +
Sbjct: 682 PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741
Query: 844 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH- 902
DP TD + + +L VFI+ +++ IL+ K+ + + RK ++ N ++ +H
Sbjct: 742 PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKL-AKKRKDAMGNTRQEMTHM 798
Query: 903 --------------HPTDPVEL----------RRLNFQTPGMAS---------------- 922
H DP+ + R N +S
Sbjct: 799 VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP 858
Query: 923 ------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYA 976
HP I + +L HI +K +D+ F +EYES GQ +W+ + + N+ KNRY
Sbjct: 859 YQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYG 918
Query: 977 NVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQR 1036
N+IAYDHSRV+L +E P SDY+NANYIDGY++ + YIATQG + ET DFWRMIW+++
Sbjct: 919 NIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQ 978
Query: 1037 SATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSE 1096
SA +VM+T L E RVKC +YWP TE +G +VT ++ LA Y VRTF L + G +E
Sbjct: 979 SACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNE 1037
Query: 1097 KREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVID 1156
REV+QF FT WPDHGVP H T L+F+RRVK NPP AGP+VVHCSAG GRTGC+IVID
Sbjct: 1038 IREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVID 1097
Query: 1157 AMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYA 1216
ML+ + E VDIY V +R++R MVQTE+QYIFIHDA+LEA CG T +P A
Sbjct: 1098 IMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKA 1157
Query: 1217 YIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLVNIMPYESTR 1274
+ +I++ N + ++ EF+ L S + A LP N KNR ++++P +
Sbjct: 1158 AYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCL 1217
Query: 1275 VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK 1334
L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR+++++ T +VML +
Sbjct: 1218 PFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNE 1276
Query: 1335 LREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQSRTVRQ 1391
+ + C QYWP E RY V+ M+ + ++ I R +T ++G V+Q
Sbjct: 1277 VDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY-LMVQQ 1333
Query: 1392 FQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVFITLSIV 1449
FQ+ W + VP S F+ I QV K +E+ + +G +HC G GR+G+F + IV
Sbjct: 1334 FQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIV 1393
Query: 1450 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1495
+E ++ + VVD+F VK LR +P MV+ +QY+F Y ALEYL S
Sbjct: 1394 VEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
Score = 62.0 bits (149), Expect = 4e-09
Identities = 87/407 (21%), Positives = 158/407 (38%), Gaps = 62/407 (15%)
Query: 246 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 299
E+ G + C+A G + K L + +D+P+ + +N R +A+
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260
Query: 300 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 348
Y CV S G + AQ+ V+ P+P P + T + + ++ +
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Query: 349 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 406
P+ ++++ + + E V Y + L P ++YE RV+ G G P
Sbjct: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
Query: 407 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 464
P++T+T P P+ ++ + + I V W+ GY + +T + T +
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
Query: 465 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515
+ HN + + + +L P S+K++ T+ S + + T V
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489
Query: 516 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 563
PG P+ E I L+W P + I YE+ Y G Q ++
Sbjct: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
Query: 564 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTA-----EISARTM 605
+ T + L P + Y F + A + +G G +TA ISA T+
Sbjct: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTL 596
Score = 60.5 bits (145), Expect = 1e-08
Identities = 95/420 (22%), Positives = 158/420 (37%), Gaps = 54/420 (12%)
Query: 171 NNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELRE 230
N I ++++I + ++++ ++DQ Y CV + G+ S A L VRE
Sbjct: 234 NGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE--- 290
Query: 231 VRRVPPRFSIPPTNHEIMPGG---SVNITCVAVGSP--MPYVKWMLGAEDLTPEDDMPIG 285
PPR PP + P +N + P + V++ + + T + +
Sbjct: 291 ----PPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWT--ETHAVN 344
Query: 286 RNVLELNDVRQSANYTCVAMST--------LGVIEAIAQITVKALPKPPGTPVVTESTAT 337
+L + Y + T L I + + P T + E A
Sbjct: 345 APTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQAR 404
Query: 338 SITLTWDS----------GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYS 387
I + W+S N +Y H ++ L ++D A ++ V L PY+
Sbjct: 405 RIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCL--DMDPKAP-QHVVNHLPPYT 461
Query: 388 DYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ 447
+ +++ N GR SE + QT E P P I + WKEP +PNG
Sbjct: 462 NVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGI 520
Query: 448 IQGYRVYY----TMDPTQHVNN--WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG 501
I Y + Y + DP V N+ +S +L P TY + A T G G
Sbjct: 521 ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580
Query: 502 PLSSDIQVITQTGVPGQP--------LNFKAEPESETSILLSWTPPRSDTIANYELVYKD 553
P ++ I V T P P LN E + ++LL + I+ Y++V ++
Sbjct: 581 PATA-INVTTNISAPTLPDYEGVDASLN---ETATTITVLLRPAQAKGAPISAYQIVVEE 636
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 504 bits (1299), Expect = e-142
Identities = 385/1255 (30%), Positives = 583/1255 (46%), Gaps = 184/1255 (14%)
Query: 379 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438
SVA + S ++R V ++ G G + L P + P L + W
Sbjct: 253 SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306
Query: 439 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 496
+P + G + ++ W + ++ DS + +L P Y ++VL
Sbjct: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366
Query: 497 SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 547
G GP + T+ P P N + + L W P + Y
Sbjct: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426
Query: 548 ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI------- 600
+ V+ ++ E+ I+ + Y L+GL+P RL +P+G S +
Sbjct: 427 QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDV 484
Query: 601 -SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA-- 656
A ++S+ F K + + W+ P N + ++I Y K V +D A
Sbjct: 485 PGAVPLESIQGGPFEEK------IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADL 535
Query: 657 -------------TQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPA 702
T L V L P +YSF + + ++A G VT + A + + P
Sbjct: 536 SSQRGKVFKLRNETHHLFVGLYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPE 593
Query: 703 FIGKTNL---DGMITVQLPEVPANENIKGYYIIIVP---LKKSRGK------FIKPWESP 750
+ T L D ITV L + Y ++V L+KSR F P
Sbjct: 594 YDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
Query: 751 DEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQS 810
+ LD L + ELKP A+ V FT+GD+K Y G+ N L
Sbjct: 654 NASSLDSL------------HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSP 697
Query: 811 GQEY-VFFVLAVMEHAESKMYAT-----SPYSDPVV-----------------SMDLDPQ 847
+ Y ++F + E+K+ +P V S ++P+
Sbjct: 698 LKSYSIYFQALSKANGETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPE 757
Query: 848 PITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKR------------------------ 883
D + V+ +L +FII ++ +L KR+R
Sbjct: 758 KQVDNTVKMAGVIAGLL--MFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQR 815
Query: 884 -------AESDSRKSSIPNNKE--------------------------IPSH--HPTDPV 908
A+ + K S N E I +H DPV
Sbjct: 816 EMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPV 875
Query: 909 ELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEV 968
E+ P P I + +L HI ++K F +EYE++ GQ +W+ + +
Sbjct: 876 EM-----SYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDE 930
Query: 969 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1028
N+ KNRY N+I+YDHSRV L ++G P SDY+NANYIDGY + YIATQG + ET DF
Sbjct: 931 NRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDF 990
Query: 1029 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1088
WRMIW++ SA++VM+T L E RVKC +YWP TE +G ++VTL++T LA Y +RTF
Sbjct: 991 WRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFT 1049
Query: 1089 LYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGR 1148
+ K G E RE+R F FT+WPDHGVP + T L F+R+VK NPP+AGP+VVHCSAG GR
Sbjct: 1050 VQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGR 1109
Query: 1149 TGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTE 1208
TGCFI ID ML+ ++E VDI+ V +RAQR +VQTE+QY+F+HDA+LEA CGNT
Sbjct: 1110 TGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTA 1169
Query: 1209 VPA---RNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLV 1265
+P R+LY I +L +T + E + + + + LP N KNR +
Sbjct: 1170 IPVCEFRSLYYNISRLDP-QTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSM 1228
Query: 1266 NIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHN 1325
+++P + L + G E S+YINA+ +D ++Q A++ TQ PL T DFWR+++++N
Sbjct: 1229 DVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYN 1287
Query: 1326 STIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ 1385
+ VVML ++ + C QYWP + S Y V+ ++ I R F++ + Q
Sbjct: 1288 CSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQ 1345
Query: 1386 S--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTG 1441
R V+ Q+ WP + P S + + ++ K +EQ+ G++G VHC G GR+G
Sbjct: 1346 DGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSG 1405
Query: 1442 VFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF 1496
F + V E ++ + ++D+F VK LR + MV+T +QY+F Y ALEYL SF
Sbjct: 1406 TFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1460
Score = 68.9 bits (167), Expect = 3e-11
Identities = 82/325 (25%), Positives = 133/325 (40%), Gaps = 34/325 (10%)
Query: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 351
R + Y CV S G + A++ VK P P P E A T W N +
Sbjct: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316
Query: 352 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 407
+ + + + + + E V + Y + L P +YE RV+ G GPP P
Sbjct: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376
Query: 408 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 466
+ T+T P P++V+ + + + +QW EP G + Y Q+V N
Sbjct: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432
Query: 467 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 520
++ + S T+ L P T +++L S +G + S+ V+ T+ VPG PL
Sbjct: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490
Query: 521 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 573
E I + W PP + I YE+ YK G ++ + G ++L+
Sbjct: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550
Query: 574 ----GLKPNSLYYFRLAARSPQGLG 594
GL P + Y F + A + +G G
Sbjct: 551 HLFVGLYPGTTYSFTIKASTAKGFG 575
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 503 bits (1295), Expect = e-142
Identities = 302/772 (39%), Positives = 431/772 (55%), Gaps = 73/772 (9%)
Query: 789 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 843
P FT+GD++ Y GF N L + Y ++F E+K AT + +
Sbjct: 682 PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741
Query: 844 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH- 902
DP TD + + +L VFI+ +++ IL+ K+ + + RK ++ N ++ +H
Sbjct: 742 PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKL-AKKRKDAMGNTRQEMTHM 798
Query: 903 --------------HPTDPVEL----------RRLNFQTPGMAS---------------- 922
H DP+ + R N +S
Sbjct: 799 VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP 858
Query: 923 ------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYA 976
HP I + +L HI +K +D+ F +EYES GQ +W+ + + N+ KNRY
Sbjct: 859 YQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYG 918
Query: 977 NVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSLPETFGDFWR 1030
N+IAYDHSRV+L +E P SDY+NANYID GY++ + YIATQG + ET DFWR
Sbjct: 919 NIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWR 978
Query: 1031 MIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALY 1090
MIW+++SA +VM+T L E RVKC +YWP TE +G +VT ++ LA Y VRTF L
Sbjct: 979 MIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLE 1037
Query: 1091 KNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1150
+ G +E REV+QF FT WPDHGVP H T L+F+RRVK NPP AGP+VVHCSAG GRTG
Sbjct: 1038 RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTG 1097
Query: 1151 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVP 1210
C+IVID ML+ + E VDIY V +R++R MVQTE+QYIFIHDA+LEA CG T +P
Sbjct: 1098 CYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIP 1157
Query: 1211 ARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLVNIM 1268
A + +I++ N + ++ EF+ L S + A LP N KNR ++++
Sbjct: 1158 VCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDML 1217
Query: 1269 PYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI 1328
P + L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR+++++ T
Sbjct: 1218 PPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTS 1276
Query: 1329 VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQ 1385
+VML ++ + C QYWP E RY V+ M+ + ++ I R +T ++G
Sbjct: 1277 IVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY 1334
Query: 1386 SRTVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVF 1443
V+QFQ+ W + VP S F+ I QV K +E+ + +G +HC G GR+G+F
Sbjct: 1335 -LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMF 1393
Query: 1444 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1495
+ IV+E ++ + VVD+F VK LR +P MV+ +QY+F Y ALEYL S
Sbjct: 1394 CAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445
Score = 62.0 bits (149), Expect = 4e-09
Identities = 87/407 (21%), Positives = 158/407 (38%), Gaps = 62/407 (15%)
Query: 246 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 299
E+ G + C+A G + K L + +D+P+ + +N R +A+
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260
Query: 300 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 348
Y CV S G + AQ+ V+ P+P P + T + + ++ +
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Query: 349 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 406
P+ ++++ + + E V Y + L P ++YE RV+ G G P
Sbjct: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
Query: 407 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 464
P++T+T P P+ ++ + + I V W+ GY + +T + T +
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
Query: 465 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515
+ HN + + + +L P S+K++ T+ S + + T V
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489
Query: 516 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 563
PG P+ E I L+W P + I YE+ Y G Q ++
Sbjct: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
Query: 564 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTA-----EISARTM 605
+ T + L P + Y F + A + +G G +TA ISA T+
Sbjct: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTL 596
Score = 60.5 bits (145), Expect = 1e-08
Identities = 95/420 (22%), Positives = 158/420 (37%), Gaps = 54/420 (12%)
Query: 171 NNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELRE 230
N I ++++I + ++++ ++DQ Y CV + G+ S A L VRE
Sbjct: 234 NGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE--- 290
Query: 231 VRRVPPRFSIPPTNHEIMPGG---SVNITCVAVGSP--MPYVKWMLGAEDLTPEDDMPIG 285
PPR PP + P +N + P + V++ + + T + +
Sbjct: 291 ----PPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWT--ETHAVN 344
Query: 286 RNVLELNDVRQSANYTCVAMST--------LGVIEAIAQITVKALPKPPGTPVVTESTAT 337
+L + Y + T L I + + P T + E A
Sbjct: 345 APTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQAR 404
Query: 338 SITLTWDS----------GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYS 387
I + W+S N +Y H ++ L ++D A ++ V L PY+
Sbjct: 405 RIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCL--DMDPKAP-QHVVNHLPPYT 461
Query: 388 DYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ 447
+ +++ N GR SE + QT E P P I + WKEP +PNG
Sbjct: 462 NVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGI 520
Query: 448 IQGYRVYY----TMDPTQHVNN--WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG 501
I Y + Y + DP V N+ +S +L P TY + A T G G
Sbjct: 521 ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580
Query: 502 PLSSDIQVITQTGVPGQP--------LNFKAEPESETSILLSWTPPRSDTIANYELVYKD 553
P ++ I V T P P LN E + ++LL + I+ Y++V ++
Sbjct: 581 PATA-INVTTNISAPTLPDYEGVDASLN---ETATTITVLLRPAQAKGAPISAYQIVVEE 636
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 498 bits (1282), Expect = e-140
Identities = 266/580 (45%), Positives = 357/580 (61%), Gaps = 12/580 (2%)
Query: 923 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 982
HP I + +L HI ++K + F +EYES GQ W+ + + N+ KNRY N+IAYD
Sbjct: 877 HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYD 936
Query: 983 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1042
HSRV L IEG SDY+N NYIDGY + N YIATQG + ET DFWRM+W + +A+++M
Sbjct: 937 HSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 996
Query: 1043 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1102
+T L E RVKC +YWP TE + ++VTL++T LA Y +RTFA+ K G E RE+RQ
Sbjct: 997 VTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQ 1055
Query: 1103 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1162
F FT WPDHGVP H T L F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+
Sbjct: 1056 FHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMA 1115
Query: 1163 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1222
+ E VDIY V +R++R MVQTE+QY+FIHDA+LEA CG+T VPA + + +
Sbjct: 1116 EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMN 1175
Query: 1223 QIETGENVTGMELEFKRL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1280
+++ N + ++ EF+ L + A LP N KNR ++I+P + L I
Sbjct: 1176 KLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI 1235
Query: 1281 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1340
G E S+YINA+ +D Y+Q A+I TQ PL T +DFWR++ +++ T VVML +
Sbjct: 1236 DG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--A 1292
Query: 1341 EKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1397
+ C QYWP R Q V E ++ I R + +DG R V+QFQF W
Sbjct: 1293 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGW 1351
Query: 1398 P-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1455
P + P S F+ I QV K +E++ G +G VHC G GR+G F +SIV E +R+
Sbjct: 1352 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1411
Query: 1456 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1495
+ VD+F VK LR +P MV DQY+F Y ALEYL S
Sbjct: 1412 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1451
Score = 137 bits (344), Expect = 1e-31
Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 969 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1028
N KNR +++ D L I+G S+Y+NA +D Y++ +A+I TQ LP T DF
Sbjct: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271
Query: 1029 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1088
WR++ + +VVM+ ++ C QYWP G HG +QV + R F
Sbjct: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329
Query: 1089 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1142
+Y + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1330 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1389
Query: 1143 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1202
G GR+G F I + E ++H++TVD++ V +R + MV DQY F ++ LE +
Sbjct: 1390 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1449
Query: 1203 TCG 1205
G
Sbjct: 1450 NSG 1452
Score = 66.6 bits (161), Expect = 2e-10
Identities = 93/436 (21%), Positives = 165/436 (37%), Gaps = 61/436 (13%)
Query: 191 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEI-MP 249
+ + + + D GKY C+ G S A L V+E P S+ T I +
Sbjct: 244 SFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLN 303
Query: 250 GGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL- 308
S+N V + Y + D P+ ++ + Y + T
Sbjct: 304 ANSINGDGPIVAREVEYC-----TASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRP 358
Query: 309 ------GVIEAIAQITVKALP-KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPK 361
A+ T A P + P V E + IT+ W EP Y + +
Sbjct: 359 GEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRW-----EPFGYNVTRCHSY 413
Query: 362 N-----------SEELYKEIDGVATT---RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEP 407
N E++ +E+ ++++ LSPY++ +++ +N GR S+
Sbjct: 414 NLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-KESQE 472
Query: 408 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHV 463
++ QT E P + P + I +QW+EP + G I Y + Y + DP +
Sbjct: 473 LIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDL 532
Query: 464 NNWMKHNVADSQITTIGN--------LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515
+N +++ +GN L P TYS + A T+ G GP +++ Q T+
Sbjct: 533 SN------QSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTTKISA 585
Query: 516 PGQPLNFKAEPESET----SILLSWTPPRSDTIANYELVYKDGEHGEEQRIT----IEPG 567
P P P ++T +++L R ++ Y++V ++ ++ T P
Sbjct: 586 PSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPV 645
Query: 568 TSYRLQGLKPNSLYYF 583
+ NS YYF
Sbjct: 646 PIHFQNASLLNSQYYF 661
Score = 63.9 bits (154), Expect = 1e-09
Identities = 95/401 (23%), Positives = 155/401 (38%), Gaps = 44/401 (10%)
Query: 244 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 294
N E+ G C A+G + + L D+ P ++ + R + N V
Sbjct: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
Query: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 350
R + Y C+ + GV I A++ VK P P P + AT I L +S N + P
Sbjct: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
Query: 351 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 408
+ +++ + + + V +T Y + L P ++YE V+ G G P +
Sbjct: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370
Query: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 464
T+T P PR ++ + S I ++W+ + Y + Y + + V
Sbjct: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430
Query: 465 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 522
+ + +S TI NL P SVK++ G S ++ V T +PG P
Sbjct: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489
Query: 523 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 569
E I L W P I YE+ YK + G ++ E T
Sbjct: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547
Query: 570 YRLQGLKPNSLYYFRLAARSPQGLGAS-----TAEISARTM 605
+ GL P + Y F + A + +G G T +ISA +M
Sbjct: 548 FLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSM 588
Score = 55.8 bits (133), Expect = 3e-07
Identities = 99/485 (20%), Positives = 177/485 (36%), Gaps = 79/485 (16%)
Query: 465 NWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSD---IQVITQTGVPGQ-PL 520
+W DS IG+L P Y + VL T G+G S ++ T+ P + P
Sbjct: 326 SWNDRQPVDSTSYKIGHLDPDTEYEISVL-LTRPGEGGTGSPGPALRTRTKCADPMRGPR 384
Query: 521 NFKAEPESETSILLSWTP-------PRSDTIANYELVYKDGEHGEEQRITIEPGTSY--- 570
+ I + W P S + + G+ + ++ + S+
Sbjct: 385 KLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQH 444
Query: 571 RLQGLKPNSLYYFRLAARSPQGLGASTAEI--------SARTMQSMFAKNFHVKAVMKTS 622
+ L P + +L +P+G S I A +S+ F K
Sbjct: 445 TITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEK------ 498
Query: 623 VLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEKS 669
+ L W P + Y ++I Y + E+D G T L L P +
Sbjct: 499 IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTT 558
Query: 670 YSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVPA 722
YSF + T +G T +AP + PA+ +T L D +TV L P
Sbjct: 559 YSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHSR 614
Query: 723 NENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVELK 778
+ Y I++ + R K +K + P + LL +
Sbjct: 615 GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS----------------Q 658
Query: 779 PYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATS 833
Y AA F + FT+GD+K Y G+ N L + Y ++F A + E+K+
Sbjct: 659 YYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQ 718
Query: 834 PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSI 893
+ + P+P + + + + G + ++ + I + ++L +KR + RK ++
Sbjct: 719 VATKGAATPKPVPEP-EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETM 777
Query: 894 PNNKE 898
+ ++
Sbjct: 778 SSTRQ 782
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 498 bits (1282), Expect = e-140
Identities = 266/580 (45%), Positives = 357/580 (61%), Gaps = 12/580 (2%)
Query: 923 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 982
HP I + +L HI ++K + F +EYES GQ W+ + + N+ KNRY N+IAYD
Sbjct: 890 HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYD 949
Query: 983 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1042
HSRV L IEG SDY+N NYIDGY + N YIATQG + ET DFWRM+W + +A+++M
Sbjct: 950 HSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 1009
Query: 1043 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1102
+T L E RVKC +YWP TE + ++VTL++T LA Y +RTFA+ K G E RE+RQ
Sbjct: 1010 VTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQ 1068
Query: 1103 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1162
F FT WPDHGVP H T L F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+
Sbjct: 1069 FHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMA 1128
Query: 1163 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1222
+ E VDIY V +R++R MVQTE+QY+FIHDA+LEA CG+T VPA + + +
Sbjct: 1129 EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMN 1188
Query: 1223 QIETGENVTGMELEFKRL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1280
+++ N + ++ EF+ L + A LP N KNR ++I+P + L I
Sbjct: 1189 KLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI 1248
Query: 1281 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1340
G E S+YINA+ +D Y+Q A+I TQ PL T +DFWR++ +++ T VVML +
Sbjct: 1249 DG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--A 1305
Query: 1341 EKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1397
+ C QYWP R Q V E ++ I R + +DG R V+QFQF W
Sbjct: 1306 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGW 1364
Query: 1398 P-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1455
P + P S F+ I QV K +E++ G +G VHC G GR+G F +SIV E +R+
Sbjct: 1365 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1424
Query: 1456 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1495
+ VD+F VK LR +P MV DQY+F Y ALEYL S
Sbjct: 1425 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464
Score = 137 bits (344), Expect = 1e-31
Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 969 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1028
N KNR +++ D L I+G S+Y+NA +D Y++ +A+I TQ LP T DF
Sbjct: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284
Query: 1029 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1088
WR++ + +VVM+ ++ C QYWP G HG +QV + R F
Sbjct: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342
Query: 1089 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1142
+Y + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1343 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1402
Query: 1143 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1202
G GR+G F I + E ++H++TVD++ V +R + MV DQY F ++ LE +
Sbjct: 1403 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1462
Query: 1203 TCG 1205
G
Sbjct: 1463 NSG 1465
Score = 66.6 bits (161), Expect = 2e-10
Identities = 93/436 (21%), Positives = 165/436 (37%), Gaps = 61/436 (13%)
Query: 191 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEI-MP 249
+ + + + D GKY C+ G S A L V+E P S+ T I +
Sbjct: 244 SFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLN 303
Query: 250 GGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL- 308
S+N V + Y + D P+ ++ + Y + T
Sbjct: 304 ANSINGDGPIVAREVEYC-----TASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRP 358
Query: 309 ------GVIEAIAQITVKALP-KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPK 361
A+ T A P + P V E + IT+ W EP Y + +
Sbjct: 359 GEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRW-----EPFGYNVTRCHSY 413
Query: 362 N-----------SEELYKEIDGVATT---RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEP 407
N E++ +E+ ++++ LSPY++ +++ +N GR S+
Sbjct: 414 NLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-KESQE 472
Query: 408 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHV 463
++ QT E P + P + I +QW+EP + G I Y + Y + DP +
Sbjct: 473 LIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDL 532
Query: 464 NNWMKHNVADSQITTIGN--------LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515
+N +++ +GN L P TYS + A T+ G GP +++ Q T+
Sbjct: 533 SN------QSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTTKISA 585
Query: 516 PGQPLNFKAEPESET----SILLSWTPPRSDTIANYELVYKDGEHGEEQRIT----IEPG 567
P P P ++T +++L R ++ Y++V ++ ++ T P
Sbjct: 586 PSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPV 645
Query: 568 TSYRLQGLKPNSLYYF 583
+ NS YYF
Sbjct: 646 PIHFQNASLLNSQYYF 661
Score = 63.9 bits (154), Expect = 1e-09
Identities = 95/401 (23%), Positives = 155/401 (38%), Gaps = 44/401 (10%)
Query: 244 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 294
N E+ G C A+G + + L D+ P ++ + R + N V
Sbjct: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
Query: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 350
R + Y C+ + GV I A++ VK P P P + AT I L +S N + P
Sbjct: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
Query: 351 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 408
+ +++ + + + V +T Y + L P ++YE V+ G G P +
Sbjct: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370
Query: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 464
T+T P PR ++ + S I ++W+ + Y + Y + + V
Sbjct: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430
Query: 465 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 522
+ + +S TI NL P SVK++ G S ++ V T +PG P
Sbjct: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489
Query: 523 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 569
E I L W P I YE+ YK + G ++ E T
Sbjct: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547
Query: 570 YRLQGLKPNSLYYFRLAARSPQGLGAS-----TAEISARTM 605
+ GL P + Y F + A + +G G T +ISA +M
Sbjct: 548 FLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSM 588
Score = 55.8 bits (133), Expect = 3e-07
Identities = 99/485 (20%), Positives = 177/485 (36%), Gaps = 79/485 (16%)
Query: 465 NWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSD---IQVITQTGVPGQ-PL 520
+W DS IG+L P Y + VL T G+G S ++ T+ P + P
Sbjct: 326 SWNDRQPVDSTSYKIGHLDPDTEYEISVL-LTRPGEGGTGSPGPALRTRTKCADPMRGPR 384
Query: 521 NFKAEPESETSILLSWTP-------PRSDTIANYELVYKDGEHGEEQRITIEPGTSY--- 570
+ I + W P S + + G+ + ++ + S+
Sbjct: 385 KLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQH 444
Query: 571 RLQGLKPNSLYYFRLAARSPQGLGASTAEI--------SARTMQSMFAKNFHVKAVMKTS 622
+ L P + +L +P+G S I A +S+ F K
Sbjct: 445 TITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEK------ 498
Query: 623 VLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEKS 669
+ L W P + Y ++I Y + E+D G T L L P +
Sbjct: 499 IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTT 558
Query: 670 YSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVPA 722
YSF + T +G T +AP + PA+ +T L D +TV L P
Sbjct: 559 YSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHSR 614
Query: 723 NENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVELK 778
+ Y I++ + R K +K + P + LL +
Sbjct: 615 GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS----------------Q 658
Query: 779 PYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATS 833
Y AA F + FT+GD+K Y G+ N L + Y ++F A + E+K+
Sbjct: 659 YYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQ 718
Query: 834 PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSI 893
+ + P+P + + + + G + ++ + I + ++L +KR + RK ++
Sbjct: 719 VATKGAATPKPVPEP-EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETM 777
Query: 894 PNNKE 898
+ ++
Sbjct: 778 SSTRQ 782
>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
precursor [Homo sapiens]
Length = 1436
Score = 464 bits (1195), Expect = e-130
Identities = 355/1134 (31%), Positives = 521/1134 (45%), Gaps = 140/1134 (12%)
Query: 466 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 523
W + + Q + +L P Y + VL T GDG TG PG PL +
Sbjct: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
Query: 524 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 561
AEP + L W P R T L Y H + R
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
Query: 562 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGL--GASTAEISARTMQSMFAKNFHVKAV 618
+ E G S Y ++ L P + RL +P+G G + + S A
Sbjct: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
Query: 619 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 665
++ + L WE P+ N + ++I Y + V G T + NL
Sbjct: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
Query: 666 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 720
P +Y F + T +G L T +AP P+ +G++ + ITV L P
Sbjct: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
Query: 721 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 779
I Y +I+ ++ R + ++ + L E + R + Y G E+
Sbjct: 617 GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
Query: 780 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 838
A FT+GD++ Y GF N L+ + Y ++F A E+++
Sbjct: 674 LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
Query: 839 VVSMDLDPQPITD--EEEGLIW-VVGPVLAVVFIICIVIAILLYKRK------------- 882
P ++ EE GLI + LAV+ ++ I +++ K K
Sbjct: 728 ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQ 787
Query: 883 -----------------------------------RAESDSRKSSIPNNKEIPSHHPTDP 907
D R + + P P
Sbjct: 788 EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRP 847
Query: 908 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLE 967
+ + T + HP + + +L HI ++K + F QEYES G W+ + +
Sbjct: 848 CGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKK 901
Query: 968 VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGD 1027
+R + AYD RV L + G P +DY+NANYIDGY + N +IATQG PE D
Sbjct: 902 DKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYD 961
Query: 1028 FWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTF 1087
FWRM+W++ +++VM+TKL E RVKC +YWP ++T+G +++ L+ T LA Y VRTF
Sbjct: 962 FWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTF 1020
Query: 1088 ALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVG 1147
AL + G S + EVRQF FTAWP+HGVP H T LAF+RRVK PPDAGP+V+HCSAG G
Sbjct: 1021 ALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTG 1080
Query: 1148 RTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNT 1207
RTGC+IV+D ML+ + E VDIY V + ++R M+QTE+QYIFIHDA+LEA CG T
Sbjct: 1081 RTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGET 1140
Query: 1208 EVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLV 1265
+P A +++ +I+ N + + EF+ L S A LP N+ KNR +
Sbjct: 1141 TIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSM 1200
Query: 1266 NIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE 1323
+++P + CL + +G ++YINA+ D Y + A+I T PL TT DFWR++++
Sbjct: 1201 DVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYD 1257
Query: 1324 HNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR 1382
+ T +VML +L + C QYWP +Y V+ M+ + R F+V +
Sbjct: 1258 YGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNIS 1317
Query: 1383 DGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGR 1439
Q VR FQF W + P S + F+ + +V K + + G DG VHC G GR
Sbjct: 1318 RLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGR 1376
Query: 1440 TGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1493
+G F + VLE +R +VD+F K LR +P MV+T DQY F Y ALEYL
Sbjct: 1377 SGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1430
Score = 62.8 bits (151), Expect = 2e-09
Identities = 76/342 (22%), Positives = 136/342 (39%), Gaps = 43/342 (12%)
Query: 300 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 355
Y CV+ + G + A++ VK P P P + + T + + ++ + P+
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Query: 356 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 413
I+++ + E+ V+ Y + L P ++YE V+ + G G P P++++T
Sbjct: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
Query: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473
P AP+ + + + + +QW EP G YT+ H HN
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
Query: 474 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 519
+ TI NL+P + V+++ G + +D V +G+ +
Sbjct: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
Query: 520 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 568
L F E I L W P+ + I YE+ Y+ E G + I+ + T
Sbjct: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
Query: 569 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSMF 609
+ L P + Y F + AR+ +G G A+ EI+ F
Sbjct: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF 592
Score = 62.4 bits (150), Expect = 3e-09
Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)
Query: 365 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 424
E K GV+ RY++ L PY + R+V N GR E V QT E PS +
Sbjct: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
Query: 425 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 478
I ++W+EP+EPNG I Y + Y + DP +V + + +
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
Query: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 531
NL P TY V A T G G ++ ++ T P PL E E+ +
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
Query: 532 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 567
+LL R I+ Y+++ E +R+ EPG
Sbjct: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 459 bits (1182), Expect = e-129
Identities = 264/678 (38%), Positives = 373/678 (55%), Gaps = 52/678 (7%)
Query: 863 VLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELRRLNFQT---- 917
V++ + +C+++ I + R + + P +E+PS R+ FQT
Sbjct: 743 VVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKC-FQTAHFY 801
Query: 918 ------PGMASHPPIPILELAD------------HIERLKANDNLKFSQEYESID---PG 956
P + + IPI+ + D HI L +N+ FS+++E +
Sbjct: 802 VEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTAD 861
Query: 957 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAY 1014
T EHSN NK KNRY N++AYDHSRV L + G SDY+NANY+DGY K AY
Sbjct: 862 MNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAY 921
Query: 1015 IATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL 1074
IATQG L TF DFWRMIWEQ + +VM+T L E+ R KCDQYWP+ +E +G + VTL
Sbjct: 922 IATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLK 981
Query: 1075 DTVELATYCVRTFALYKN-----------GSSEKREVRQFQFTAWPDHGVPEHPTPFLAF 1123
T A Y VR F++ G +R V Q+ +T WPD GVPE+ P L F
Sbjct: 982 STKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTF 1041
Query: 1124 LRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNY 1183
+RR P+ GP++VHCSAGVGRTG +IVID+ML++IK + TV++ G + +R QRNY
Sbjct: 1042 VRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNY 1101
Query: 1184 MVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASS 1243
+VQTE+QYIFIHDALLEA+ TEV + L++Y+ + G T +E +FK +
Sbjct: 1102 LVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVG-GKTRLEKQFKLVTQC 1160
Query: 1244 KAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAY 1303
A SA CNK KNR +++P E RV L P+ G++G+DYINAS+I GY + +
Sbjct: 1161 NAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEF 1220
Query: 1304 IATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA-ERSARYQYFVV-- 1360
I TQ PL TT+DFWRM+W+HN+ I+VML + + ++ YWP+ E S + F V
Sbjct: 1221 IITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTL 1279
Query: 1361 ---DPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVH 1417
D + N Q I+ +F + +D VR FQ WP P S + I +
Sbjct: 1280 ISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVI- 1336
Query: 1418 KTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQ 1477
+E +DGP VH G G+ L+ + +++ E VD+FQ KM+ RP +
Sbjct: 1337 -KEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFT 1395
Query: 1478 TEDQYQFSYRAALEYLGS 1495
+QYQF Y+A L + +
Sbjct: 1396 DIEQYQFIYKAMLSLVST 1413
>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
precursor [Homo sapiens]
Length = 1442
Score = 458 bits (1178), Expect = e-128
Identities = 355/1140 (31%), Positives = 521/1140 (45%), Gaps = 146/1140 (12%)
Query: 466 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 523
W + + Q + +L P Y + VL T GDG TG PG PL +
Sbjct: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
Query: 524 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 561
AEP + L W P R T L Y H + R
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
Query: 562 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGL--GASTAEISARTMQSMFAKNFHVKAV 618
+ E G S Y ++ L P + RL +P+G G + + S A
Sbjct: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
Query: 619 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 665
++ + L WE P+ N + ++I Y + V G T + NL
Sbjct: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
Query: 666 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 720
P +Y F + T +G L T +AP P+ +G++ + ITV L P
Sbjct: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
Query: 721 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 779
I Y +I+ ++ R + ++ + L E + R + Y G E+
Sbjct: 617 GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
Query: 780 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 838
A FT+GD++ Y GF N L+ + Y ++F A E+++
Sbjct: 674 LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
Query: 839 VVSMDLDPQPITD--EEEGLIW-VVGPVLAVVFIICIVIAILLYKRK------------- 882
P ++ EE GLI + LAV+ ++ I +++ K K
Sbjct: 728 ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQ 787
Query: 883 -----------------------------------RAESDSRKSSIPNNKEIPSHHPTDP 907
D R + + P P
Sbjct: 788 EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRP 847
Query: 908 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLE 967
+ + T + HP + + +L HI ++K + F QEYES G W+ + +
Sbjct: 848 CGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKK 901
Query: 968 VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSL 1021
+R + AYD RV L + G P +DY+NANYID GY + N +IATQG
Sbjct: 902 DKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPK 961
Query: 1022 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1081
PE DFWRM+W++ +++VM+TKL E RVKC +YWP ++T+G +++ L+ T LA
Sbjct: 962 PEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAE 1020
Query: 1082 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVH 1141
Y VRTFAL + G S + EVRQF FTAWP+HGVP H T LAF+RRVK PPDAGP+V+H
Sbjct: 1021 YVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIH 1080
Query: 1142 CSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEA 1201
CSAG GRTGC+IV+D ML+ + E VDIY V + ++R M+QTE+QYIFIHDA+LEA
Sbjct: 1081 CSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA 1140
Query: 1202 VTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNK 1259
CG T +P A +++ +I+ N + + EF+ L S A LP N+
Sbjct: 1141 CLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR 1200
Query: 1260 FKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDF 1317
KNR ++++P + CL + +G ++YINA+ D Y + A+I T PL TT DF
Sbjct: 1201 DKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDF 1257
Query: 1318 WRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1376
WR+++++ T +VML +L + C QYWP +Y V+ M+ + R F
Sbjct: 1258 WRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVF 1317
Query: 1377 KVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC 1433
+V + Q VR FQF W + P S + F+ + +V K + + G DG VHC
Sbjct: 1318 RVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHC 1376
Query: 1434 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1493
G GR+G F + VLE +R +VD+F K LR +P MV+T DQY F Y ALEYL
Sbjct: 1377 LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1436
Score = 62.8 bits (151), Expect = 2e-09
Identities = 76/342 (22%), Positives = 136/342 (39%), Gaps = 43/342 (12%)
Query: 300 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 355
Y CV+ + G + A++ VK P P P + + T + + ++ + P+
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Query: 356 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 413
I+++ + E+ V+ Y + L P ++YE V+ + G G P P++++T
Sbjct: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
Query: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473
P AP+ + + + + +QW EP G YT+ H HN
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
Query: 474 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 519
+ TI NL+P + V+++ G + +D V +G+ +
Sbjct: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
Query: 520 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 568
L F E I L W P+ + I YE+ Y+ E G + I+ + T
Sbjct: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
Query: 569 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSMF 609
+ L P + Y F + AR+ +G G A+ EI+ F
Sbjct: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF 592
Score = 62.4 bits (150), Expect = 3e-09
Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)
Query: 365 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 424
E K GV+ RY++ L PY + R+V N GR E V QT E PS +
Sbjct: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
Query: 425 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 478
I ++W+EP+EPNG I Y + Y + DP +V + + +
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
Query: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 531
NL P TY V A T G G ++ ++ T P PL E E+ +
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
Query: 532 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 567
+LL R I+ Y+++ E +R+ EPG
Sbjct: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
precursor [Homo sapiens]
Length = 1446
Score = 449 bits (1156), Expect = e-126
Identities = 249/615 (40%), Positives = 351/615 (57%), Gaps = 19/615 (3%)
Query: 887 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 946
D R + + P P + + T + HP + + +L HI ++K + F
Sbjct: 837 DQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGF 894
Query: 947 SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID 1006
QEYES G W+ + + +R + AYD RV L + G P +DY+NANYID
Sbjct: 895 KQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYID 950
Query: 1007 GYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH 1066
GY + N +IATQG PE DFWRM+W++ +++VM+TKL E RVKC +YWP ++T+
Sbjct: 951 GYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTY 1009
Query: 1067 GLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRR 1126
G +++ L+ T LA Y VRTFAL + G S + EVRQF FTAWP+HGVP H T LAF+RR
Sbjct: 1010 GDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRR 1069
Query: 1127 VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ 1186
VK PPDAGP+V+HCSAG GRTGC+IV+D ML+ + E VDIY V + ++R M+Q
Sbjct: 1070 VKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQ 1129
Query: 1187 TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SK 1244
TE+QYIFIHDA+LEA CG T +P A +++ +I+ N + + EF+ L S
Sbjct: 1130 TEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPP 1189
Query: 1245 AHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKA 1302
A LP N+ KNR ++++P + CL + +G ++YINA+ D Y + A
Sbjct: 1190 LDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAA 1246
Query: 1303 YIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVD 1361
+I T PL TT DFWR+++++ T +VML +L + C QYWP +Y V+
Sbjct: 1247 FIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVE 1306
Query: 1362 PMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHK 1418
M+ + R F+V + Q VR FQF W + P S + F+ + +V K
Sbjct: 1307 FMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDK 1366
Query: 1419 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1478
+ + G DG VHC G GR+G F + VLE +R +VD+F K LR +P MV+T
Sbjct: 1367 WQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVET 1425
Query: 1479 EDQYQFSYRAALEYL 1493
DQY F Y ALEYL
Sbjct: 1426 MDQYHFCYDVALEYL 1440
Score = 62.8 bits (151), Expect = 2e-09
Identities = 76/342 (22%), Positives = 136/342 (39%), Gaps = 43/342 (12%)
Query: 300 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 355
Y CV+ + G + A++ VK P P P + + T + + ++ + P+
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Query: 356 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 413
I+++ + E+ V+ Y + L P ++YE V+ + G G P P++++T
Sbjct: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
Query: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473
P AP+ + + + + +QW EP G YT+ H HN
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
Query: 474 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 519
+ TI NL+P + V+++ G + +D V +G+ +
Sbjct: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
Query: 520 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 568
L F E I L W P+ + I YE+ Y+ E G + I+ + T
Sbjct: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
Query: 569 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSMF 609
+ L P + Y F + AR+ +G G A+ EI+ F
Sbjct: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF 592
Score = 62.4 bits (150), Expect = 3e-09
Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)
Query: 365 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 424
E K GV+ RY++ L PY + R+V N GR E V QT E PS +
Sbjct: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
Query: 425 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 478
I ++W+EP+EPNG I Y + Y + DP +V + + +
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
Query: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 531
NL P TY V A T G G ++ ++ T P PL E E+ +
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
Query: 532 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 567
+LL R I+ Y+++ E +R+ EPG
Sbjct: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
Score = 41.6 bits (96), Expect = 0.006
Identities = 105/465 (22%), Positives = 169/465 (36%), Gaps = 73/465 (15%)
Query: 466 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 523
W + + Q + +L P Y + VL T GDG TG PG PL +
Sbjct: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
Query: 524 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 561
AEP + L W P R T L Y H + R
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
Query: 562 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGL--GASTAEISARTMQSMFAKNFHVKAV 618
+ E G S Y ++ L P + RL +P+G G + + S A
Sbjct: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
Query: 619 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 665
++ + L WE P+ N + ++I Y + V G T + NL
Sbjct: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
Query: 666 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 720
P +Y F + T +G L T +AP P+ +G++ + ITV L P
Sbjct: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
Query: 721 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 779
I Y +I+ ++ R + ++ + L E + R + Y G E+
Sbjct: 617 GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
Query: 780 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 838
A FT+GD++ Y GF N L+ + Y ++F A E+++
Sbjct: 674 LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
Query: 839 VVSMDLDPQPIT--DEEEGLI-WVVGPVLAVVFIICIVIAILLYK 880
P ++ EE GLI + LAV+ ++ I +++ K
Sbjct: 728 ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRK 772
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 424 bits (1089), Expect = e-118
Identities = 245/615 (39%), Positives = 345/615 (56%), Gaps = 43/615 (6%)
Query: 917 TPGMASHPPIPILELAD------------HIERLKANDNL--------KFSQEYESIDPG 956
+P + S PP PI ++D H+ L A+ +F QE +S
Sbjct: 1678 SPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVD 1737
Query: 957 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAY 1014
T + SN NK KNRY N++AYDHSRV L+ + G +DY+NANY+DGY + AY
Sbjct: 1738 LGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAY 1797
Query: 1015 IATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL 1074
IA QG L T DFWRMIWE +VM+T L E+ R KCDQYWP+ G+E +G VT
Sbjct: 1798 IAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQK 1857
Query: 1075 DTVELATYCVRTFAL----YKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFLAFLRR 1126
LA Y VR F L K GS + R V Q+ +T WPD GVPE+ P L F+R+
Sbjct: 1858 SVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRK 1917
Query: 1127 VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ 1186
GP+VVHCSAGVGRTG +IV+D+ML++I+HE TV+I+G + +R+QRNY+VQ
Sbjct: 1918 AAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQ 1977
Query: 1187 TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAH 1246
TE+QY+FIHD L+EA+ TEV +++AY+ L I T +E +F+ L+ S
Sbjct: 1978 TEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALL-IPGPAGKTKLEKQFQLLSQSNIQ 2036
Query: 1247 TSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIAT 1306
S + +A CN+ KNR +I+P E +RV + + G EG+DYINAS+I GY Q +I T
Sbjct: 2037 QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIIT 2095
Query: 1307 QGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE 1365
Q PL T +DFWRM+W+HN+ +VVM+ + M ++ YWP + + F V MAE
Sbjct: 2096 QHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAE 2154
Query: 1366 -----YNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTK 1420
N + I+++F + +D VR FQ WP P S + I + +
Sbjct: 2155 EHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVI--KE 2210
Query: 1421 EQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED 1480
E +DGP+ VH G G F L+ ++ ++ E VD++Q KM+ RP + +
Sbjct: 2211 EAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIE 2270
Query: 1481 QYQFSYRAALEYLGS 1495
QYQF Y+ L + +
Sbjct: 2271 QYQFLYKVILSLVST 2285
Score = 115 bits (288), Expect = 3e-25
Identities = 77/264 (29%), Positives = 129/264 (48%), Gaps = 10/264 (3%)
Query: 957 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIA 1016
QQ + + + N+ KNR +++I + SRV +S++ G G+DY+NA+YI GY + N +I
Sbjct: 2036 QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFII 2094
Query: 1017 TQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH-GLVQVTLLD 1075
TQ L T DFWRMIW+ + VVM+ + + + YWP++ + +VTL+
Sbjct: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKDEPINCESFKVTLMA 2153
Query: 1076 TVELAT-----YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC 1130
++ F L EVR FQ WP+ P T L + + +
Sbjct: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAA 2213
Query: 1131 NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQ 1190
N GPM+VH G G F + ++ +++ E +VD+Y ++ R + +Q
Sbjct: 2214 NRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQ 2271
Query: 1191 YIFIHDALLEAVTCGNTEVPARNL 1214
Y F++ +L V+ E P+ +L
Sbjct: 2272 YQFLYKVILSLVSTRQEENPSTSL 2295
Score = 35.0 bits (79), Expect = 0.55
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 7/83 (8%)
Query: 518 QPLNFKAEPESETSILLSWTPPR---SDTIANYELVYK--DGEHGEEQRITIE--PGTSY 570
+P N +A+PE+ TS+L++W PR I + ++Y+ DGE + +
Sbjct: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGA 373
Query: 571 RLQGLKPNSLYYFRLAARSPQGL 593
L L PN Y ++ A GL
Sbjct: 374 ILNNLLPNMSYVLQIVAICTNGL 396
Score = 31.6 bits (70), Expect = 6.0
Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 8/91 (8%)
Query: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEP-NGQIQGYRVYYTM----DPTQHVNNWMK 468
E SS P +VQA + T++LV W+ P + I+ + V Y D T+H ++
Sbjct: 308 EAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKH--EFLT 365
Query: 469 HNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
D + NL+P +Y ++++A + G
Sbjct: 366 DGYQDLG-AILNNLLPNMSYVLQIVAICTNG 395
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
precursor [Homo sapiens]
Length = 1256
Score = 396 bits (1018), Expect = e-110
Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)
Query: 925 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 983
PI L + +R A++ F E++SI +F + + N+ KNRY +++ YD+
Sbjct: 582 PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 641
Query: 984 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1043
+RV LS I G GS+Y+NA+YIDG+++ YIA QG ET DFWRMIWEQ++ +VM+
Sbjct: 642 NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 701
Query: 1044 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1100
T+ EE +R KC +YWPS GT G V V + Y ++ + K + REV
Sbjct: 702 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 761
Query: 1101 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1160
QFT+WPDHGVPE P L RRV + +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 762 THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 821
Query: 1161 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1220
++ E VD+YG+V +R QR MVQ E QYI IH AL+E G TEV L+ Y+
Sbjct: 822 GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 881
Query: 1221 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1278
+ + + + +E EF+RL S ++ ++ I N NK KNR N++PY+ RV L+
Sbjct: 882 MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 940
Query: 1279 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1321
E S YINASFI Y + + IA QGPL ET DFW+M+
Sbjct: 941 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1000
Query: 1322 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1381
++ ++VMLT+L+ +E C QYW E Y VD Y LR F++ +
Sbjct: 1001 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1059
Query: 1382 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1433
+ SRTV Q+Q+T+W + +P + I I V K ++ +G P+ +HC
Sbjct: 1060 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1119
Query: 1434 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1486
G +TG+F L +LE E VVDIFQ VK LR RP MV T +QYQF Y
Sbjct: 1120 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172
Score = 197 bits (501), Expect = 6e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 622 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681
Query: 1313 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1370
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 682 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741
Query: 1371 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1429
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 742 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799
Query: 1430 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1489
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E QY ++A
Sbjct: 800 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
Query: 1490 LEY 1492
+EY
Sbjct: 860 VEY 862
Score = 156 bits (395), Expect = 1e-37
Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)
Query: 926 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 980
+ + EL ++ +K D E++ + + + +H N E NK KNR +NVI
Sbjct: 870 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 929
Query: 981 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1021
YD++RV L S + SD Y+NA++I Y K IA QG L
Sbjct: 930 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 989
Query: 1022 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1081
ET GDFW+MI++++ +VM+T+L+ + C QYW G +T+G ++V L DT + +T
Sbjct: 990 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 1048
Query: 1082 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1134
Y +R F L + + R V Q+Q+T W +P P ++ ++ VK P
Sbjct: 1049 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 1108
Query: 1135 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1191
+ P+++HC G +TG F + +LE + E+ VDI+ V +R R MV T +QY
Sbjct: 1109 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1168
Query: 1192 IFIHDALLEAVTCGNTEVPARN 1213
F++D + N +V N
Sbjct: 1169 QFLYDVIASTYPAQNGQVKKNN 1190
Score = 34.3 bits (77), Expect = 0.93
Identities = 39/161 (24%), Positives = 69/161 (42%), Gaps = 19/161 (11%)
Query: 430 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 487
+ TTI ++WK E +T D TQ++ + + + D++ + NL P+
Sbjct: 267 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 314
Query: 488 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 547
Y + +S I + T G PG+P E+ +++W PP+ + N+
Sbjct: 315 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 372
Query: 548 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAA 587
L Y + E+ + ++ Y LQ LKP + Y L A
Sbjct: 373 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHA 411
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
precursor [Homo sapiens]
Length = 1304
Score = 396 bits (1018), Expect = e-110
Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)
Query: 925 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 983
PI L + +R A++ F E++SI +F + + N+ KNRY +++ YD+
Sbjct: 630 PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 689
Query: 984 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1043
+RV LS I G GS+Y+NA+YIDG+++ YIA QG ET DFWRMIWEQ++ +VM+
Sbjct: 690 NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 749
Query: 1044 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1100
T+ EE +R KC +YWPS GT G V V + Y ++ + K + REV
Sbjct: 750 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 809
Query: 1101 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1160
QFT+WPDHGVPE P L RRV + +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 810 THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 869
Query: 1161 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1220
++ E VD+YG+V +R QR MVQ E QYI IH AL+E G TEV L+ Y+
Sbjct: 870 GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 929
Query: 1221 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1278
+ + + + +E EF+RL S ++ ++ I N NK KNR N++PY+ RV L+
Sbjct: 930 MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 988
Query: 1279 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1321
E S YINASFI Y + + IA QGPL ET DFW+M+
Sbjct: 989 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1048
Query: 1322 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1381
++ ++VMLT+L+ +E C QYW E Y VD Y LR F++ +
Sbjct: 1049 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1107
Query: 1382 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1433
+ SRTV Q+Q+T+W + +P + I I V K ++ +G P+ +HC
Sbjct: 1108 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1167
Query: 1434 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1486
G +TG+F L +LE E VVDIFQ VK LR RP MV T +QYQF Y
Sbjct: 1168 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1220
Score = 197 bits (501), Expect = 6e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 670 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 729
Query: 1313 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1370
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 730 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 789
Query: 1371 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1429
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 790 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 847
Query: 1430 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1489
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E QY ++A
Sbjct: 848 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907
Query: 1490 LEY 1492
+EY
Sbjct: 908 VEY 910
Score = 156 bits (395), Expect = 1e-37
Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)
Query: 926 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 980
+ + EL ++ +K D E++ + + + +H N E NK KNR +NVI
Sbjct: 918 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 977
Query: 981 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1021
YD++RV L S + SD Y+NA++I Y K IA QG L
Sbjct: 978 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 1037
Query: 1022 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1081
ET GDFW+MI++++ +VM+T+L+ + C QYW G +T+G ++V L DT + +T
Sbjct: 1038 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 1096
Query: 1082 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1134
Y +R F L + + R V Q+Q+T W +P P ++ ++ VK P
Sbjct: 1097 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 1156
Query: 1135 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1191
+ P+++HC G +TG F + +LE + E+ VDI+ V +R R MV T +QY
Sbjct: 1157 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1216
Query: 1192 IFIHDALLEAVTCGNTEVPARN 1213
F++D + N +V N
Sbjct: 1217 QFLYDVIASTYPAQNGQVKKNN 1238
Score = 34.3 bits (77), Expect = 0.93
Identities = 39/161 (24%), Positives = 69/161 (42%), Gaps = 19/161 (11%)
Query: 430 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 487
+ TTI ++WK E +T D TQ++ + + + D++ + NL P+
Sbjct: 315 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 362
Query: 488 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 547
Y + +S I + T G PG+P E+ +++W PP+ + N+
Sbjct: 363 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 420
Query: 548 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAA 587
L Y + E+ + ++ Y LQ LKP + Y L A
Sbjct: 421 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHA 459
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
precursor [Homo sapiens]
Length = 1143
Score = 396 bits (1018), Expect = e-110
Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)
Query: 925 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 983
PI L + +R A++ F E++SI +F + + N+ KNRY +++ YD+
Sbjct: 469 PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 528
Query: 984 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1043
+RV LS I G GS+Y+NA+YIDG+++ YIA QG ET DFWRMIWEQ++ +VM+
Sbjct: 529 NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 588
Query: 1044 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1100
T+ EE +R KC +YWPS GT G V V + Y ++ + K + REV
Sbjct: 589 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 648
Query: 1101 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1160
QFT+WPDHGVPE P L RRV + +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 649 THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 708
Query: 1161 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1220
++ E VD+YG+V +R QR MVQ E QYI IH AL+E G TEV L+ Y+
Sbjct: 709 GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 768
Query: 1221 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1278
+ + + + +E EF+RL S ++ ++ I N NK KNR N++PY+ RV L+
Sbjct: 769 MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 827
Query: 1279 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1321
E S YINASFI Y + + IA QGPL ET DFW+M+
Sbjct: 828 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 887
Query: 1322 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1381
++ ++VMLT+L+ +E C QYW E Y VD Y LR F++ +
Sbjct: 888 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 946
Query: 1382 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1433
+ SRTV Q+Q+T+W + +P + I I V K ++ +G P+ +HC
Sbjct: 947 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1006
Query: 1434 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1486
G +TG+F L +LE E VVDIFQ VK LR RP MV T +QYQF Y
Sbjct: 1007 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059
Score = 197 bits (501), Expect = 6e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568
Query: 1313 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1370
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 569 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628
Query: 1371 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1429
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 629 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686
Query: 1430 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1489
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E QY ++A
Sbjct: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
Query: 1490 LEY 1492
+EY
Sbjct: 747 VEY 749
Score = 156 bits (395), Expect = 1e-37
Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)
Query: 926 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 980
+ + EL ++ +K D E++ + + + +H N E NK KNR +NVI
Sbjct: 757 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 816
Query: 981 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1021
YD++RV L S + SD Y+NA++I Y K IA QG L
Sbjct: 817 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 876
Query: 1022 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1081
ET GDFW+MI++++ +VM+T+L+ + C QYW G +T+G ++V L DT + +T
Sbjct: 877 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 935
Query: 1082 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1134
Y +R F L + + R V Q+Q+T W +P P ++ ++ VK P
Sbjct: 936 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 995
Query: 1135 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1191
+ P+++HC G +TG F + +LE + E+ VDI+ V +R R MV T +QY
Sbjct: 996 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1055
Query: 1192 IFIHDALLEAVTCGNTEVPARN 1213
F++D + N +V N
Sbjct: 1056 QFLYDVIASTYPAQNGQVKKNN 1077
Score = 34.3 bits (77), Expect = 0.93
Identities = 39/161 (24%), Positives = 69/161 (42%), Gaps = 19/161 (11%)
Query: 430 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 487
+ TTI ++WK E +T D TQ++ + + + D++ + NL P+
Sbjct: 154 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 201
Query: 488 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 547
Y + +S I + T G PG+P E+ +++W PP+ + N+
Sbjct: 202 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 259
Query: 548 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAA 587
L Y + E+ + ++ Y LQ LKP + Y L A
Sbjct: 260 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHA 298
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,592,029
Number of Sequences: 37866
Number of extensions: 2821364
Number of successful extensions: 15823
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 298
Number of HSP's successfully gapped in prelim test: 210
Number of HSP's that attempted gapping in prelim test: 6661
Number of HSP's gapped (non-prelim): 3392
length of query: 1501
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1386
effective length of database: 13,892,928
effective search space: 19255598208
effective search space used: 19255598208
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.