Search of human proteins with 18860892

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|18860892 protein tyrosine phosphatase, receptor type, D
isoform 3 precursor [Homo sapiens]
         (1903 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...  3850   0.0  
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...  3843   0.0  
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...  3804   0.0  
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...  2814   0.0  
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...  2804   0.0  
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...  2697   0.0  
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...  2689   0.0  
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo...  1897   0.0  
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...  1891   0.0  
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...  1541   0.0  
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...  1541   0.0  
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor...   602   e-171
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo...   601   e-171
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo...   601   e-171
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor...   556   e-158
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo...   550   e-156
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo...   509   e-144
gi|208431815 protein tyrosine phosphatase, receptor type, K isof...   503   e-142
gi|157419150 protein tyrosine phosphatase, receptor type, M isof...   498   e-140
gi|157419152 protein tyrosine phosphatase, receptor type, M isof...   498   e-140
gi|148539860 protein tyrosine phosphatase, receptor type, T isof...   495   e-139
gi|148539858 protein tyrosine phosphatase, receptor type, T isof...   490   e-138
gi|194097398 protein tyrosine phosphatase, receptor type, G prec...   459   e-129
gi|110735404 protein tyrosine phosphatase, receptor type, U isof...   454   e-127
gi|110735402 protein tyrosine phosphatase, receptor type, U isof...   449   e-126
gi|110735406 protein tyrosine phosphatase, receptor type, U isof...   448   e-125
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p...   424   e-118
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo...   396   e-110
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo...   396   e-110
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo...   396   e-110

>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
            precursor [Homo sapiens]
          Length = 1903

 Score = 3850 bits (9985), Expect = 0.0
 Identities = 1903/1903 (100%), Positives = 1903/1903 (100%)

Query: 1    MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
            MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1    MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60

Query: 61   GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
            GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61   GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120

Query: 121  IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
            IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121  IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180

Query: 181  ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
            ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI
Sbjct: 181  ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240

Query: 241  PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
            PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 241  PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300

Query: 301  TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
            TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 301  TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360

Query: 361  KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
            KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 361  KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420

Query: 421  PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
            PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 421  PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480

Query: 481  NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
            NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 481  NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540

Query: 541  SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
            SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 541  SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600

Query: 601  SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 660
            SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH
Sbjct: 601  SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 660

Query: 661  EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV 720
            EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV
Sbjct: 661  EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV 720

Query: 721  EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISG 780
            EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISG
Sbjct: 721  EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISG 780

Query: 781  LQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDT 840
            LQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDT
Sbjct: 781  LQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDT 840

Query: 841  FGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVK 900
            FGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVK
Sbjct: 841  FGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVK 900

Query: 901  EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPME 960
            EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPME
Sbjct: 901  EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPME 960

Query: 961  QLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAV 1020
            QLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAV
Sbjct: 961  QLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAV 1020

Query: 1021 MKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRG 1080
            MKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRG
Sbjct: 1021 MKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRG 1080

Query: 1081 NSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKK 1140
            NSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKK
Sbjct: 1081 NSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKK 1140

Query: 1141 SRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDK 1200
            SRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDK
Sbjct: 1141 SRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDK 1200

Query: 1201 HYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIW 1260
            HYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIW
Sbjct: 1201 HYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIW 1260

Query: 1261 VVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTP 1320
            VVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTP
Sbjct: 1261 VVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTP 1320

Query: 1321 GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANV 1380
            GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANV
Sbjct: 1321 GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANV 1380

Query: 1381 IAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSA 1440
            IAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSA
Sbjct: 1381 IAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSA 1440

Query: 1441 TVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKR 1500
            TVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKR
Sbjct: 1441 TVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKR 1500

Query: 1501 EVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAM 1560
            EVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAM
Sbjct: 1501 EVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAM 1560

Query: 1561 LERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYI 1620
            LERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYI
Sbjct: 1561 LERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYI 1620

Query: 1621 QKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ 1680
            QKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ
Sbjct: 1621 QKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ 1680

Query: 1681 PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREM 1740
            PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREM
Sbjct: 1681 PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREM 1740

Query: 1741 GREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWP 1800
            GREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWP
Sbjct: 1741 GREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWP 1800

Query: 1801 EQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV 1860
            EQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV
Sbjct: 1801 EQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV 1860

Query: 1861 VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1903
            VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT
Sbjct: 1861 VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1903


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score = 3843 bits (9965), Expect = 0.0
 Identities = 1903/1912 (99%), Positives = 1903/1912 (99%), Gaps = 9/1912 (0%)

Query: 1    MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
            MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1    MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60

Query: 61   GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
            GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61   GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120

Query: 121  IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
            IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121  IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180

Query: 181  ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
            ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI
Sbjct: 181  ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240

Query: 241  PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
            PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 241  PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300

Query: 301  TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
            TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 301  TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360

Query: 361  KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
            KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 361  KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420

Query: 421  PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
            PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 421  PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480

Query: 481  NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
            NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 481  NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540

Query: 541  SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
            SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 541  SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600

Query: 601  SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 660
            SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH
Sbjct: 601  SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 660

Query: 661  EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV 720
            EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV
Sbjct: 661  EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV 720

Query: 721  EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ------ 774
            EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ      
Sbjct: 721  EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDT 780

Query: 775  ---DMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL 831
               DMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL
Sbjct: 781  TEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL 840

Query: 832  IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK 891
            IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK
Sbjct: 841  IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK 900

Query: 892  VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 951
            VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD
Sbjct: 901  VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 960

Query: 952  INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF 1011
            INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF
Sbjct: 961  INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF 1020

Query: 1012 AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS 1071
            AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS
Sbjct: 1021 AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS 1080

Query: 1072 YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY 1131
            YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY
Sbjct: 1081 YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY 1140

Query: 1132 YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP 1191
            YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP
Sbjct: 1141 YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP 1200

Query: 1192 TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI 1251
            TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI
Sbjct: 1201 TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI 1260

Query: 1252 TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE 1311
            TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE
Sbjct: 1261 TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE 1320

Query: 1312 LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN 1371
            LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN
Sbjct: 1321 LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN 1380

Query: 1372 KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW 1431
            KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW
Sbjct: 1381 KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW 1440

Query: 1432 RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL 1491
            RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL
Sbjct: 1441 RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL 1500

Query: 1492 YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT 1551
            YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT
Sbjct: 1501 YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT 1560

Query: 1552 GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV 1611
            GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV
Sbjct: 1561 GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV 1620

Query: 1612 PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP 1671
            PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP
Sbjct: 1621 PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP 1680

Query: 1672 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV 1731
            YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV
Sbjct: 1681 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV 1740

Query: 1732 VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV 1791
            VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV
Sbjct: 1741 VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV 1800

Query: 1792 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1851
            RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV
Sbjct: 1801 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1860

Query: 1852 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1903
            LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT
Sbjct: 1861 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1912


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score = 3804 bits (9865), Expect = 0.0
 Identities = 1890/1912 (98%), Positives = 1890/1912 (98%), Gaps = 22/1912 (1%)

Query: 1    MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
            MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1    MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60

Query: 61   GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
            GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61   GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120

Query: 121  IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
            IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121  IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180

Query: 181  ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
                     GALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVR    VRRVPPRFSI
Sbjct: 181  ---------GALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVPPRFSI 227

Query: 241  PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
            PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 228  PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 287

Query: 301  TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
            TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 288  TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 347

Query: 361  KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
            KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 348  KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 407

Query: 421  PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
            PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 408  PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 467

Query: 481  NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
            NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 468  NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 527

Query: 541  SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
            SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 528  SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 587

Query: 601  SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 660
            SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH
Sbjct: 588  SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 647

Query: 661  EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV 720
            EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV
Sbjct: 648  EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV 707

Query: 721  EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ------ 774
            EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ      
Sbjct: 708  EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDT 767

Query: 775  ---DMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL 831
               DMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL
Sbjct: 768  TEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL 827

Query: 832  IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK 891
            IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK
Sbjct: 828  IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK 887

Query: 892  VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 951
            VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD
Sbjct: 888  VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 947

Query: 952  INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF 1011
            INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF
Sbjct: 948  INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF 1007

Query: 1012 AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS 1071
            AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS
Sbjct: 1008 AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS 1067

Query: 1072 YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY 1131
            YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY
Sbjct: 1068 YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY 1127

Query: 1132 YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP 1191
            YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP
Sbjct: 1128 YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP 1187

Query: 1192 TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI 1251
            TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI
Sbjct: 1188 TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI 1247

Query: 1252 TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE 1311
            TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE
Sbjct: 1248 TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE 1307

Query: 1312 LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN 1371
            LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN
Sbjct: 1308 LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN 1367

Query: 1372 KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW 1431
            KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW
Sbjct: 1368 KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW 1427

Query: 1432 RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL 1491
            RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL
Sbjct: 1428 RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL 1487

Query: 1492 YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT 1551
            YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT
Sbjct: 1488 YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT 1547

Query: 1552 GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV 1611
            GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV
Sbjct: 1548 GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV 1607

Query: 1612 PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP 1671
            PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP
Sbjct: 1608 PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP 1667

Query: 1672 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV 1731
            YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV
Sbjct: 1668 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV 1727

Query: 1732 VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV 1791
            VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV
Sbjct: 1728 VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV 1787

Query: 1792 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1851
            RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV
Sbjct: 1788 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1847

Query: 1852 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1903
            LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT
Sbjct: 1848 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1899


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score = 2814 bits (7295), Expect = 0.0
 Identities = 1381/1924 (71%), Positives = 1602/1924 (83%), Gaps = 44/1924 (2%)

Query: 20   AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
            AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29   AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88

Query: 80   SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
            +VLRIQPLRTPRDE +YECVA N+VGEI+V  +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89   AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148

Query: 140  TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
            TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRSE+   TPIRGALQIE SEE
Sbjct: 149  TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEE 208

Query: 200  SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
            +DQGKYECVATNSAG RYS+PANLYVRELREVRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 209  TDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVA 268

Query: 260  VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319
            VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 269  VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 328

Query: 320  KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379
            K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ +  Y+  + + TTRYS
Sbjct: 329  KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 388

Query: 380  VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439
            + GLSP S+YE  V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 389  IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 448

Query: 440  EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
            EP EPNG I+GYRVYYTM+P   V NW KHNV DS +TT+G+L+  +TY+V+VLAFTS+G
Sbjct: 449  EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 508

Query: 500  DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559
            DGPLS  IQV TQ GVPGQP+N +AE  SETSI LSW+PPR ++I  YEL++++G+HG E
Sbjct: 509  DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 568

Query: 560  QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619
               T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T  +  RT+QSKPSAPPQD+ C 
Sbjct: 569  VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 628

Query: 620  SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679
            S  ST+ILVSW+PPP E  NG +  YS++Y  +  ED +P E+ GIP  TT+ LLE LEK
Sbjct: 629  SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 688

Query: 680  WTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK 739
            WT+YRIT  AHT+VGPGPES  V++RT+EDVPS PPRKVE EA+N+T+++V WRSP P +
Sbjct: 689  WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 748

Query: 740  QHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ---------DMIISGLQPETSYSLT 790
            QHGQIRGYQVHYVRME  E +G P +KDVMLADAQ         +M+I+ LQPET+YS+T
Sbjct: 749  QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSIT 808

Query: 791  VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTF-GPLQGYRL 849
            V AYT KGDGARSKPK+V T GAV G+P L +  T   + L +W PP  T    + GYRL
Sbjct: 809  VAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRL 868

Query: 850  KFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVP 909
            +FGR+D  PL TLEF   ED +TA+ +HKGA+YVFRL+AR++ G GEE  + +SIPE+ P
Sbjct: 869  QFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTP 928

Query: 910  TGFPQNLHSEGTTST-SVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVP--- 965
             G PQ L + G  S  +V L W PPV AERNG I KYT+  R+    L P  +  +P   
Sbjct: 929  RGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAG-ALGPARETELPAAA 987

Query: 966  ---ADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMK 1022
               A+  +TL GLKPDT YD++VRAHT +GPGP+SP V++RT   DQV  KNF VK +MK
Sbjct: 988  EPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMK 1047

Query: 1023 TSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNS 1082
            TSVLLSWE P+NYNS  P+KI Y+   +  +VDGR T+KLI +LKP   Y+FVLTNRG+S
Sbjct: 1048 TSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSS 1105

Query: 1083 AGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSR 1142
             GGLQ  VTA TA ++L  KP+   K + DG I V LP+  +   ++ Y+I++VPL+KSR
Sbjct: 1106 LGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSR 1165

Query: 1143 -GKFIKPWESPDEMELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDD 1199
             G+F+ P  SP++M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP  F  GD 
Sbjct: 1166 GGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQ 1225

Query: 1200 KHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLI 1259
            K YGGF N+ L+ G  YV FVLAV++ +E   +A SP+SDP    + DPQPI D EEGLI
Sbjct: 1226 KQYGGFDNRGLEPGHRYVLFVLAVLQKSE-PTFAASPFSDPFQLDNPDPQPIVDGEEGLI 1284

Query: 1260 WVVGPVLAVVFIICIVIAILLYKR----KRAESDSRKSSIPNNKEIPSHHPTDPVELRRL 1315
            WV+GPVLAVVFIICIVIAILLYK     KR +S+ R   + NN ++  HHP DPVE+RR+
Sbjct: 1285 WVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRI 1344

Query: 1316 NFQTP----------------GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ 1359
            NFQTP                 M SHPPIPI ++A+H ERLKAND+LK SQEYESIDPGQ
Sbjct: 1345 NFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ 1404

Query: 1360 QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIAT 1419
            QFTWEHSNLEVNKPKNRYANVIAYDHSRV+L  IEGI GSDY+NANY+DGYR QNAYIAT
Sbjct: 1405 QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIAT 1464

Query: 1420 QGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTV 1479
            QG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QVTLLDT+
Sbjct: 1465 QGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTI 1524

Query: 1480 ELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGP 1539
            ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP
Sbjct: 1525 ELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGP 1584

Query: 1540 MVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDA 1599
            +VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY FIH+A
Sbjct: 1585 IVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEA 1644

Query: 1600 LLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPC 1659
            LLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFISANLPC
Sbjct: 1645 LLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPC 1704

Query: 1660 NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF 1719
            NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF
Sbjct: 1705 NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF 1764

Query: 1720 WRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFK 1779
            WRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFK
Sbjct: 1765 WRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFK 1824

Query: 1780 VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV 1839
            VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV
Sbjct: 1825 VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV 1884

Query: 1840 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFD 1899
            GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALEYLGSFD
Sbjct: 1885 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFD 1944

Query: 1900 HYAT 1903
            HYAT
Sbjct: 1945 HYAT 1948



 Score =  186 bits (471), Expect = 2e-46
 Identities = 218/898 (24%), Positives = 355/898 (39%), Gaps = 126/898 (14%)

Query: 16   LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75
            LR      PRF+  P+    + GG  +  C A G P P + W         Q  E +  +
Sbjct: 237  LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 288

Query: 76   DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135
            D       +  L   +D A Y CVA +++G I    ++TV    + P G P         
Sbjct: 289  DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 339

Query: 136  VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIE 195
            V E T T+  +   SGNPDP ++++                                 IE
Sbjct: 340  VTENTATSITITWDSGNPDP-VSYY--------------------------------VIE 366

Query: 196  QSEESDQGKYECVATNSAGTRYS-------APANLYVRELREVRRVPPRFSIPPTNHEIM 248
               +S  G Y+ +  +   TRYS       +   ++V  +  + + PP  S+     E  
Sbjct: 367  YKSKSQDGPYQ-IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQA 425

Query: 249  PGGSV-NITCVAVGSPMPYVKWMLGAED----------LTPEDDMPIG----RNV----- 288
            P  +  N+    + +    V+W    E            T E + P+G     NV     
Sbjct: 426  PASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLL 485

Query: 289  LELNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTW 343
              +  + +   YT   +A +++G       I VK     PG P+   + A   TSITL+W
Sbjct: 486  TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSW 545

Query: 344  DSGNPEP-VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRG 402
                 E  + Y ++  +  +  E+ +  D   TT Y V  L P ++Y FR+ A +  G G
Sbjct: 546  SPPRQESIIKYELLFREGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLG 603

Query: 403  PPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYY----T 456
              +  V  +T +  PS+ P+DV+   + ST ILV W+   PE  NG + GY V Y    +
Sbjct: 604  AFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGS 663

Query: 457  MDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP 516
             DP     N +        +     L     Y +  +A T +G GP SS + V T   VP
Sbjct: 664  EDPEPKEVNGIPPTTTQILLEA---LEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 720

Query: 517  -GQPLNFKAEPESETSILLSWTPP----RSDTIANYELVYKDGEHGE------------- 558
               P   +AE  + T+I + W  P    +   I  Y++ Y   E  E             
Sbjct: 721  SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 780

Query: 559  EQRITIEPGTSYR--LQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDI 616
            + +   +    Y   +  L+P + Y   +AA + +G GA +      T  +    P   +
Sbjct: 781  DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 840

Query: 617  SCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQ 676
              T     S+L  W+PP    ++ ++  Y +++     ED  P   L  P    +Y    
Sbjct: 841  QQTPEG--SLLARWEPPAGTAEDQVL-GYRLQF---GREDSTPLATLEFPPSEDRYTASG 894

Query: 677  LEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEA-VNSTSVKVSWRSP 735
            + K   Y   + A +  G G E+  VL    ED P G P+ +E     ++ +V + W  P
Sbjct: 895  VHKGATYVFRLAARSRGGLGEEAAEVL-SIPEDTPRGHPQILEAAGNASAGTVLLRWLPP 953

Query: 736  VPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQD-MIISGLQPETSYSLTVTAY 794
            VP +++G I  Y V         P  +  L       A++ + + GL+P+T+Y L V A+
Sbjct: 954  VPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAH 1013

Query: 795  TTKGDGARSKPKLVSTTGAVPGKPR-LVINHTQMNTALIQWHPPVDTFGPLQGYRLKF 851
            T +G G  S P    T       P+   +      + L+ W  P D +     Y++++
Sbjct: 1014 TRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFP-DNYNSPTPYKIQY 1070


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score = 2804 bits (7269), Expect = 0.0
 Identities = 1373/1899 (72%), Positives = 1593/1899 (83%), Gaps = 32/1899 (1%)

Query: 20   AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
            AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29   AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88

Query: 80   SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
            +VLRIQPLRTPRDE +YECVA N+VGEI+V  +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89   AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148

Query: 140  TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
            TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS         GALQIE SEE
Sbjct: 149  TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS---------GALQIESSEE 199

Query: 200  SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
            +DQGKYECVATNSAG RYS+PANLYVR    VRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200  TDQGKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSILPMSHEIMPGGNVNITCVA 255

Query: 260  VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319
            VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 256  VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 315

Query: 320  KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379
            K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ +  Y+  + + TTRYS
Sbjct: 316  KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 375

Query: 380  VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439
            + GLSP S+YE  V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 376  IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 435

Query: 440  EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
            EP EPNG I+GYRVYYTM+P   V NW KHNV DS +TT+G+L+  +TY+V+VLAFTS+G
Sbjct: 436  EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 495

Query: 500  DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559
            DGPLS  IQV TQ GVPGQP+N +AE  SETSI LSW+PPR ++I  YEL++++G+HG E
Sbjct: 496  DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 555

Query: 560  QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619
               T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T  +  RT+QSKPSAPPQD+ C 
Sbjct: 556  VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 615

Query: 620  SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679
            S  ST+ILVSW+PPP E  NG +  YS++Y  +  ED +P E+ GIP  TT+ LLE LEK
Sbjct: 616  SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 675

Query: 680  WTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK 739
            WT+YRIT  AHT+VGPGPES  V++RT+EDVPS PPRKVE EA+N+T+++V WRSP P +
Sbjct: 676  WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 735

Query: 740  QHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGD 799
            QHGQIRGYQVHYVRME  E +G P +KDVMLADAQ+M+I+ LQPET+YS+TV AYT KGD
Sbjct: 736  QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGD 795

Query: 800  GARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTF-GPLQGYRLKFGRKDMEP 858
            GARSKPK+V T GAV G+P L +  T   + L +W PP  T    + GYRL+FGR+D  P
Sbjct: 796  GARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTP 855

Query: 859  LTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHS 918
            L TLEF   ED +TA+ +HKGA+YVFRL+AR++ G GEE  + +SIPE+ P G PQ L +
Sbjct: 856  LATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEA 915

Query: 919  EGTTST-SVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPA------DTTMT 971
             G  S  +V L W PPV AERNG I KYT+  R+    L P  +  +PA      +  +T
Sbjct: 916  AGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGA-LGPARETELPAAAEPGAENALT 974

Query: 972  LTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEI 1031
            L GLKPDT YD++VRAHT +GPGP+SP V++RT   DQV  KNF VK +MKTSVLLSWE 
Sbjct: 975  LQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEF 1034

Query: 1032 PENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVT 1091
            P+NYNS  P+KI Y+   +  +VDGR T+KLI +LKP   Y+FVLTNRG+S GGLQ  VT
Sbjct: 1035 PDNYNSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVT 1092

Query: 1092 AKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWE 1150
            A TA ++L  KP+   K + DG I V LP+  +   ++ Y+I++VPL+KSRG +F+ P  
Sbjct: 1093 AWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLG 1152

Query: 1151 SPDEMELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNK 1208
            SP++M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP  F  GD K YGGF N+
Sbjct: 1153 SPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNR 1212

Query: 1209 QLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAV 1268
             L+ G  YV FVLAV++ +E   +A SP+SDP    + DPQPI D EEGLIWV+GPVLAV
Sbjct: 1213 GLEPGHRYVLFVLAVLQKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAV 1271

Query: 1269 VFIICIVIAILLYKRK----RAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMAS 1324
            VFIICIVIAILLYK K    R +S+ R   + NN ++  HHP DPVE+RR+NFQTPGM S
Sbjct: 1272 VFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLS 1331

Query: 1325 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1384
            HPPIPI ++A+H ERLKAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD
Sbjct: 1332 HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1391

Query: 1385 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1444
            HSRV+L  IEGI GSDY+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQRSAT+VM
Sbjct: 1392 HSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVM 1451

Query: 1445 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1504
            MT+LEE+SR+KCDQYWP+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQ
Sbjct: 1452 MTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1511

Query: 1505 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1564
            FQFTAWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERI
Sbjct: 1512 FQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI 1571

Query: 1565 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1624
            K EKTVD+YGHVTLMR+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL 
Sbjct: 1572 KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA 1631

Query: 1625 QIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRG 1684
            Q+E GE+VTGMELEFKRLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRG
Sbjct: 1632 QVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRG 1691

Query: 1685 VEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREK 1744
            VEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREK
Sbjct: 1692 VEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREK 1751

Query: 1745 CHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGV 1804
            CHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGV
Sbjct: 1752 CHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGV 1811

Query: 1805 PKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF 1864
            PKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF
Sbjct: 1812 PKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF 1871

Query: 1865 QTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1903
            QTVKMLRTQRPAMVQTED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1872 QTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1910


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score = 2697 bits (6991), Expect = 0.0
 Identities = 1333/1901 (70%), Positives = 1561/1901 (82%), Gaps = 26/1901 (1%)

Query: 9    LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68
            L++L        ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 18   LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77

Query: 69   FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128
            FEVIEFDDG+GSVLRIQPLR  RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 78   FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137

Query: 129  DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPI 188
            DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRS        
Sbjct: 138  DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRS-------- 189

Query: 189  RGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIM 248
             GALQIE SEESDQGKYECVATNSAGTRYSAPANLYVR    VRRV PRFSIPP++ E+M
Sbjct: 190  -GALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSIPPSSQEVM 244

Query: 249  PGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL 308
            PGGSVN+TCVAVG+PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+L
Sbjct: 245  PGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL 304

Query: 309  GVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYK 368
            G+IEA AQ+TVKALPKPP   VVTE+TATS+TLTWDSGN EPV+YY IQ++   +E  ++
Sbjct: 305  GMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQ 364

Query: 369  EIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARM 428
            E+DGVATTRYS+ GLSP+S+Y FRV+AVN+IGRGPPSE V  +T EQAPSS PR VQARM
Sbjct: 365  EVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARM 424

Query: 429  LSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTY 488
            LS++T+LVQW+ PEEPNG ++GYRVYYT D  +  N W KHN     +TT+G+L+P  TY
Sbjct: 425  LSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITY 484

Query: 489  SVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYE 548
            S++VLAFT++GDGP S  IQV TQ GVP QP +F+AE ES+T I LSW  P  + I  YE
Sbjct: 485  SLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYE 544

Query: 549  LVYKDGEHGEEQ-RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607
            LVY   E  ++Q ++T +P +SY L+ LKP++LY F+LAARS  G+G  T  I ART QS
Sbjct: 545  LVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQS 604

Query: 608  KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPS 667
             PSAPPQ + C S  ST++ VSW PPP + +NG+IT+YS+ Y AVDGED   H + GI  
Sbjct: 605  TPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISR 664

Query: 668  DTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS 727
            + + + L  LEKWTEYR+ V AHTDVGPGPES  VL+RT+EDVPSGPPRKVEVE +NST+
Sbjct: 665  EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTA 724

Query: 728  VKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSY 787
            V V W+ PVP+KQHGQIRGYQV YVR+ENGEP+G P+++DVMLA+AQ+  ISGL PET+Y
Sbjct: 725  VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTY 784

Query: 788  SLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGY 847
            S+TV AYTTKGDGARSKPK+V+TTGAVPG+P ++I+ T MNTAL+QWHPP +  G L GY
Sbjct: 785  SVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGY 844

Query: 848  RLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEE 907
            RL++ R D     T++F + + HFT T +HKG +Y+FRL+A+N+ G GEE  KEI  PE+
Sbjct: 845  RLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPED 904

Query: 908  VPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPAD 967
            +P+GFPQNLH  G T+++ +L+W PPVLAERNG I  YT+++RDIN      E   +  D
Sbjct: 905  LPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQ---QELQNITTD 961

Query: 968  TTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLL 1027
            T  TLTGLKPDTTYD+KVRA TSKG GP SPS+Q RT+PV+QVFAKNF V A MKTSVLL
Sbjct: 962  TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLL 1021

Query: 1028 SWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQ 1087
            SWE+P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P   YSFVL NRG+SAGGLQ
Sbjct: 1022 SWEVPDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQ 1079

Query: 1088 HRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIK 1147
            H V+ +TAPD+L  KP        DG   + +P V     ++ +YI++VP+ +  G  + 
Sbjct: 1080 HLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLT 1139

Query: 1148 P-WESPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAHFDVLPTEFTLGDDKHYGG 1204
            P W +P+E+ELDELL+ I +     R  R     LKPY+AA  DVLP  FTLGD K+Y G
Sbjct: 1140 PRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRG 1199

Query: 1205 FTNKQLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVG 1263
            F N+ L     Y  FVLA + E  + K YA+SPYSD +V      Q    EE  ++WV G
Sbjct: 1200 FYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQ--QEEPEMLWVTG 1257

Query: 1264 PVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELRRLNFQTPGM 1322
            PVLAV+ II IVIAILL+KRKR  S S K       K+    H +DPVE+RRLN+QTPGM
Sbjct: 1258 PVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGM 1317

Query: 1323 ASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIA 1382
              HPPIPI +LAD+IERLKAND LKFSQEYESIDPGQQFTWE+SNLEVNKPKNRYANVIA
Sbjct: 1318 RDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIA 1377

Query: 1383 YDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATV 1442
            YDHSRV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG LPET GDFWRM+WEQR+ATV
Sbjct: 1378 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1437

Query: 1443 VMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREV 1502
            VMMT+LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVELATY VRTFAL+K+GSSEKRE+
Sbjct: 1438 VMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKREL 1497

Query: 1503 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1562
            RQFQF AWPDHGVPE+PTP LAFLRRVK CNP DAGPMVVHCSAGVGRTGCFIVIDAMLE
Sbjct: 1498 RQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLE 1557

Query: 1563 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1622
            R+KHEKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALLEA TCG+TEVPARNLYA+IQK
Sbjct: 1558 RMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQK 1617

Query: 1623 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1682
            L Q+  GE+VT MELEFK LASSKAHTSRFISANLPCNKFKNRLVNIMPYE TRVCLQPI
Sbjct: 1618 LGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPI 1677

Query: 1683 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1742
            RGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWEHNSTI+VMLTKLREMGR
Sbjct: 1678 RGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGR 1737

Query: 1743 EKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQ 1802
            EKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT+RQFQFTDWPEQ
Sbjct: 1738 EKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQ 1797

Query: 1803 GVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVD 1862
            GVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVFITLSIVLERMRYEGVVD
Sbjct: 1798 GVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVD 1857

Query: 1863 IFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1903
            +FQTVK LRTQRPAMVQTEDQYQ  YRAALEYLGSFDHYAT
Sbjct: 1858 MFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1898


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score = 2689 bits (6971), Expect = 0.0
 Identities = 1333/1910 (69%), Positives = 1561/1910 (81%), Gaps = 35/1910 (1%)

Query: 9    LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68
            L++L        ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 18   LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77

Query: 69   FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128
            FEVIEFDDG+GSVLRIQPLR  RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 78   FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137

Query: 129  DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPI 188
            DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRS        
Sbjct: 138  DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRS-------- 189

Query: 189  RGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIM 248
             GALQIE SEESDQGKYECVATNSAGTRYSAPANLYVR    VRRV PRFSIPP++ E+M
Sbjct: 190  -GALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSIPPSSQEVM 244

Query: 249  PGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL 308
            PGGSVN+TCVAVG+PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+L
Sbjct: 245  PGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL 304

Query: 309  GVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYK 368
            G+IEA AQ+TVKALPKPP   VVTE+TATS+TLTWDSGN EPV+YY IQ++   +E  ++
Sbjct: 305  GMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQ 364

Query: 369  EIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARM 428
            E+DGVATTRYS+ GLSP+S+Y FRV+AVN+IGRGPPSE V  +T EQAPSS PR VQARM
Sbjct: 365  EVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARM 424

Query: 429  LSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTY 488
            LS++T+LVQW+ PEEPNG ++GYRVYYT D  +  N W KHN     +TT+G+L+P  TY
Sbjct: 425  LSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITY 484

Query: 489  SVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYE 548
            S++VLAFT++GDGP S  IQV TQ GVP QP +F+AE ES+T I LSW  P  + I  YE
Sbjct: 485  SLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYE 544

Query: 549  LVYKDGEHGEEQ-RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607
            LVY   E  ++Q ++T +P +SY L+ LKP++LY F+LAARS  G+G  T  I ART QS
Sbjct: 545  LVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQS 604

Query: 608  KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPS 667
             PSAPPQ + C S  ST++ VSW PPP + +NG+IT+YS+ Y AVDGED   H + GI  
Sbjct: 605  TPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISR 664

Query: 668  DTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS 727
            + + + L  LEKWTEYR+ V AHTDVGPGPES  VL+RT+EDVPSGPPRKVEVE +NST+
Sbjct: 665  EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTA 724

Query: 728  VKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ---------DMII 778
            V V W+ PVP+KQHGQIRGYQV YVR+ENGEP+G P+++DVMLA+AQ         +  I
Sbjct: 725  VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTI 784

Query: 779  SGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPV 838
            SGL PET+YS+TV AYTTKGDGARSKPK+V+TTGAVPG+P ++I+ T MNTAL+QWHPP 
Sbjct: 785  SGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPK 844

Query: 839  DTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEM 898
            +  G L GYRL++ R D     T++F + + HFT T +HKG +Y+FRL+A+N+ G GEE 
Sbjct: 845  ELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEF 904

Query: 899  VKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLP 958
             KEI  PE++P+GFPQNLH  G T+++ +L+W PPVLAERNG I  YT+++RDIN     
Sbjct: 905  EKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQ--- 961

Query: 959  MEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVK 1018
             E   +  DT  TLTGLKPDTTYD+KVRA TSKG GP SPS+Q RT+PV+QVFAKNF V 
Sbjct: 962  QELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVA 1021

Query: 1019 AVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTN 1078
            A MKTSVLLSWE+P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P   YSFVL N
Sbjct: 1022 AAMKTSVLLSWEVPDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPNTEYSFVLMN 1079

Query: 1079 RGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPL 1138
            RG+SAGGLQH V+ +TAPD+L  KP        DG   + +P V     ++ +YI++VP+
Sbjct: 1080 RGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPI 1139

Query: 1139 KKSRGKFIKP-WESPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAHFDVLPTEFT 1195
             +  G  + P W +P+E+ELDELL+ I +     R  R     LKPY+AA  DVLP  FT
Sbjct: 1140 DRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFT 1199

Query: 1196 LGDDKHYGGFTNKQLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMDLDPQPITDE 1254
            LGD K+Y GF N+ L     Y  FVLA + E  + K YA+SPYSD +V      Q    E
Sbjct: 1200 LGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQ--QE 1257

Query: 1255 EEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELR 1313
            E  ++WV GPVLAV+ II IVIAILL+KRKR  S S K       K+    H +DPVE+R
Sbjct: 1258 EPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMR 1317

Query: 1314 RLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKP 1373
            RLN+QTPGM  HPPIPI +LAD+IERLKAND LKFSQEYESIDPGQQFTWE+SNLEVNKP
Sbjct: 1318 RLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKP 1377

Query: 1374 KNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRM 1433
            KNRYANVIAYDHSRV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG LPET GDFWRM
Sbjct: 1378 KNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRM 1437

Query: 1434 IWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK 1493
            +WEQR+ATVVMMT+LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVELATY VRTFAL+K
Sbjct: 1438 VWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHK 1497

Query: 1494 NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGC 1553
            +GSSEKRE+RQFQF AWPDHGVPE+PTP LAFLRRVK CNP DAGPMVVHCSAGVGRTGC
Sbjct: 1498 SGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGC 1557

Query: 1554 FIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA 1613
            FIVIDAMLER+KHEKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALLEA TCG+TEVPA
Sbjct: 1558 FIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPA 1617

Query: 1614 RNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYE 1673
            RNLYA+IQKL Q+  GE+VT MELEFK LASSKAHTSRFISANLPCNKFKNRLVNIMPYE
Sbjct: 1618 RNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYE 1677

Query: 1674 STRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVM 1733
             TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWEHNSTI+VM
Sbjct: 1678 LTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVM 1737

Query: 1734 LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQ 1793
            LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT+RQ
Sbjct: 1738 LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQ 1797

Query: 1794 FQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLE 1853
            FQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVFITLSIVLE
Sbjct: 1798 FQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLE 1857

Query: 1854 RMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1903
            RMRYEGVVD+FQTVK LRTQRPAMVQTEDQYQ  YRAALEYLGSFDHYAT
Sbjct: 1858 RMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1907


>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
            precursor [Homo sapiens]
          Length = 1501

 Score = 1897 bits (4913), Expect = 0.0
 Identities = 966/1199 (80%), Positives = 1021/1199 (85%), Gaps = 31/1199 (2%)

Query: 714  PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
            PP    V    +TS+ ++W S  P           V Y  +++     + + K++     
Sbjct: 325  PPGTPVVTESTATSITLTWDSGNPEP---------VSYYIIQHKPKNSEELYKEIDGVAT 375

Query: 774  QDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLV-INHTQMNTAL 831
                ++GL P + Y   V A    G G  S+P L  T+   P   PR V        T L
Sbjct: 376  TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTIL 435

Query: 832  IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT--DIHKGASYVFRLSAR 889
            +QW  P +  G +QGYR+ +     + +         D    T  ++    +Y  ++ A 
Sbjct: 436  VQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAF 495

Query: 890  NKVGFGE-----EMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITK 944
              +G G      +++ +  +P     G P N  +E  + TS+ LSW PP    R+  I  
Sbjct: 496  TSIGDGPLSSDIQVITQTGVP-----GQPLNFKAEPESETSILLSWTPP----RSDTIAN 546

Query: 945  YTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1004
            Y L+Y+D        +++ +   T+  L GLKP++ Y  ++ A + +G G  +  +  RT
Sbjct: 547  YELVYKDGEHG--EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISART 604

Query: 1005 LPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIV 1064
            +    +FAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIV
Sbjct: 605  M--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIV 662

Query: 1065 NLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA 1124
            NLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA
Sbjct: 663  NLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA 722

Query: 1125 NENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIA 1184
            NENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIA
Sbjct: 723  NENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIA 782

Query: 1185 AHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSM 1244
            AHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSM
Sbjct: 783  AHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSM 842

Query: 1245 DLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH 1304
            DLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH
Sbjct: 843  DLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH 902

Query: 1305 HPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWE 1364
            HPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWE
Sbjct: 903  HPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWE 962

Query: 1365 HSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP 1424
            HSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP
Sbjct: 963  HSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP 1022

Query: 1425 ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATY 1484
            ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATY
Sbjct: 1023 ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATY 1082

Query: 1485 CVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHC 1544
            CVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHC
Sbjct: 1083 CVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHC 1142

Query: 1545 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1604
            SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
Sbjct: 1143 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1202

Query: 1605 TCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKN 1664
            TCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKN
Sbjct: 1203 TCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKN 1262

Query: 1665 RLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLW 1724
            RLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLW
Sbjct: 1263 RLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLW 1322

Query: 1725 EHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR 1784
            EHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR
Sbjct: 1323 EHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR 1382

Query: 1785 DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGV 1844
            DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGV
Sbjct: 1383 DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGV 1442

Query: 1845 FITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1903
            FITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT
Sbjct: 1443 FITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1501



 Score = 1226 bits (3172), Expect = 0.0
 Identities = 613/633 (96%), Positives = 620/633 (97%), Gaps = 3/633 (0%)

Query: 1   MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
           MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1   MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60

Query: 61  GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
           GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61  GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120

Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
           IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180

Query: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
           ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI
Sbjct: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240

Query: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
           PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300

Query: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
           TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360

Query: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
           KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420

Query: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
           PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480

Query: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
           NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540

Query: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
           SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600

Query: 601 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPP 633
           SARTMQS  +   ++    +   TS+L+SW+ P
Sbjct: 601 SARTMQSMFA---KNFHVKAVMKTSVLLSWEIP 630



 Score =  138 bits (347), Expect = 6e-32
 Identities = 124/428 (28%), Positives = 195/428 (45%), Gaps = 37/428 (8%)

Query: 583  FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
            +   A S  G+  + A+I+ + +   P  P      T  ++TSI ++W     E  +  I
Sbjct: 300  YTCVAMSTLGVIEAIAQITVKALPKPPGTPV----VTESTATSITLTWDSGNPEPVSYYI 355

Query: 643  TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702
             ++  K       ++   EI G+   TT+Y +  L  +++Y   V A  ++G GP S  V
Sbjct: 356  IQHKPK-----NSEELYKEIDGVA--TTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 408

Query: 703  LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 762
            L +T+E  PS  PR V+   ++ST++ V W+   P + +GQI+GY+V+Y  M+  +    
Sbjct: 409  LTQTSEQAPSSAPRDVQARMLSSTTILVQWKE--PEEPNGQIQGYRVYYT-MDPTQHVNN 465

Query: 763  PMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVI 822
             M  +V  AD+Q   I  L P+ +YS+ V A+T+ GDG  S    V T   VPG+P    
Sbjct: 466  WMKHNV--ADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK 523

Query: 823  NHTQMNTA-LIQWHPP-VDTFGPLQGYRL--KFGRKDMEPLTTLEFSEKEDHFTATDIHK 878
               +  T+ L+ W PP  DT   +  Y L  K G    E   T+   E    +    +  
Sbjct: 524  AEPESETSILLSWTPPRSDT---IANYELVYKDGEHGEEQRITI---EPGTSYRLQGLKP 577

Query: 879  GASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAER 938
             + Y FRL+AR+  G G     EIS    + + F +N H +    TSV LSW+ P   E 
Sbjct: 578  NSLYYFRLAARSPQGLGAS-TAEIS-ARTMQSMFAKNFHVKAVMKTSVLLSWEIP---EN 632

Query: 939  NGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSP 998
                  + +LY D       M + +    T   +  LKP+ +Y   V  +     G    
Sbjct: 633  YNSAMPFKILYDDGK-----MVEEVDGRATQKLIVNLKPEKSYSF-VLTNRGNSAGGLQH 686

Query: 999  SVQFRTLP 1006
             V  +T P
Sbjct: 687  RVTAKTAP 694



 Score = 98.2 bits (243), Expect = 7e-20
 Identities = 138/611 (22%), Positives = 239/611 (39%), Gaps = 92/611 (15%)

Query: 41  ASFICQATGDPRPKIVWNKKGKKV----SNQRFEVIEFDDGSGSVLR--IQPLRTPR-DE 93
           A+ +C A+G+P P+I W K    V    +N R + +  +   G+ +R  +Q  ++   D+
Sbjct: 143 ATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQ 202

Query: 94  AIYECVASNNVG-EISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGN 152
             YECVA+N+ G   S    L V    ++ R  P   + P    +    +  + C A G+
Sbjct: 203 GKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGS 262

Query: 153 PDPEITWF---KDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVA 209
           P P + W    +D  P D                   PI G   +E ++      Y CVA
Sbjct: 263 PMPYVKWMLGAEDLTPEDDM-----------------PI-GRNVLELNDVRQSANYTCVA 304

Query: 210 TNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCV-AVGSPMPYVK 268
            ++ G    A A + V+ L +          PP    +    + +IT     G+P P   
Sbjct: 305 MSTLGV-IEAIAQITVKALPK----------PPGTPVVTESTATSITLTWDSGNPEPVSY 353

Query: 269 WMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGT 328
           +++  +   P++   + + +    D   +  Y+   +S     E            PP  
Sbjct: 354 YIIQHK---PKNSEELYKEI----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSE 406

Query: 329 PVVTEST-----------------ATSITLTWDSGNPEP--------VSYYIIQHKPKNS 363
           PV+T+++                 +T+I + W     EP        V Y +   +  N+
Sbjct: 407 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNN 465

Query: 364 EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 423
              +   D   TT   +  L P   Y  +V+A  +IG GP S  +   T    P   P +
Sbjct: 466 WMKHNVADSQITT---IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLN 521

Query: 424 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 483
            +A   S T+IL+ W  P      I  Y + Y     +H     +  +       +  L 
Sbjct: 522 FKAEPESETSILLSWTPPRSDT--IANYELVYK--DGEHGEE-QRITIEPGTSYRLQGLK 576

Query: 484 PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRS-D 542
           P   Y  ++ A +  G G  +++I   T   +  +  NF  +   +TS+LLSW  P + +
Sbjct: 577 PNSLYYFRLAARSPQGLGASTAEISARTMQSMFAK--NFHVKAVMKTSVLLSWEIPENYN 634

Query: 543 TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAS---TAE 599
           +   ++++Y DG+  EE        T   +  LKP   Y F L  R     G     TA+
Sbjct: 635 SAMPFKILYDDGKMVEE---VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAK 691

Query: 600 ISARTMQSKPS 610
            +   +++KP+
Sbjct: 692 TAPDVLRTKPA 702


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
            precursor [Homo sapiens]
          Length = 1502

 Score = 1891 bits (4898), Expect = 0.0
 Identities = 966/1203 (80%), Positives = 1021/1203 (84%), Gaps = 35/1203 (2%)

Query: 714  PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
            PP    V    +TS+ ++W S  P           V Y  +++     + + K++     
Sbjct: 322  PPGTPVVTESTATSITLTWDSGNPEP---------VSYYIIQHKPKNSEELYKEIDGVAT 372

Query: 774  QDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLV-INHTQMNTAL 831
                ++GL P + Y   V A    G G  S+P L  T+   P   PR V        T L
Sbjct: 373  TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTIL 432

Query: 832  IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT--DIHKGASYVFRLSAR 889
            +QW  P +  G +QGYR+ +     + +         D    T  ++    +Y  ++ A 
Sbjct: 433  VQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAF 492

Query: 890  NKVGFGE-----EMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITK 944
              +G G      +++ +  +P     G P N  +E  + TS+ LSW PP    R+  I  
Sbjct: 493  TSIGDGPLSSDIQVITQTGVP-----GQPLNFKAEPESETSILLSWTPP----RSDTIAN 543

Query: 945  YTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1004
            Y L+Y+D        +++ +   T+  L GLKP++ Y  ++ A + +G G  +  +  RT
Sbjct: 544  YELVYKDGEHG--EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISART 601

Query: 1005 LPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIV 1064
            +    +FAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIV
Sbjct: 602  M--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIV 659

Query: 1065 NLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA 1124
            NLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA
Sbjct: 660  NLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA 719

Query: 1125 NENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIA 1184
            NENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIA
Sbjct: 720  NENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIA 779

Query: 1185 AHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSM 1244
            AHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSM
Sbjct: 780  AHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSM 839

Query: 1245 DLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYK----RKRAESDSRKSSIPNNKE 1300
            DLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYK    RKRAESDSRKSSIPNNKE
Sbjct: 840  DLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKE 899

Query: 1301 IPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQ 1360
            IPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQ
Sbjct: 900  IPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQ 959

Query: 1361 FTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQ 1420
            FTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQ
Sbjct: 960  FTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQ 1019

Query: 1421 GSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVE 1480
            GSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVE
Sbjct: 1020 GSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVE 1079

Query: 1481 LATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPM 1540
            LATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPM
Sbjct: 1080 LATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPM 1139

Query: 1541 VVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1600
            VVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL
Sbjct: 1140 VVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1199

Query: 1601 LEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCN 1660
            LEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCN
Sbjct: 1200 LEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCN 1259

Query: 1661 KFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFW 1720
            KFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFW
Sbjct: 1260 KFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFW 1319

Query: 1721 RMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV 1780
            RMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV
Sbjct: 1320 RMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV 1379

Query: 1781 TDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVG 1840
            TDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVG
Sbjct: 1380 TDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVG 1439

Query: 1841 RTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDH 1900
            RTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDH
Sbjct: 1440 RTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDH 1499

Query: 1901 YAT 1903
            YAT
Sbjct: 1500 YAT 1502



 Score = 1216 bits (3145), Expect = 0.0
 Identities = 610/633 (96%), Positives = 617/633 (97%), Gaps = 6/633 (0%)

Query: 1   MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
           MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1   MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60

Query: 61  GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
           GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61  GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120

Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
           IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180

Query: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
              GGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI
Sbjct: 181 ---GGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 237

Query: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
           PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 238 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 297

Query: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
           TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 298 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 357

Query: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
           KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 358 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 417

Query: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
           PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 418 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 477

Query: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
           NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 478 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 537

Query: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
           SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 538 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 597

Query: 601 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPP 633
           SARTMQS  +   ++    +   TS+L+SW+ P
Sbjct: 598 SARTMQSMFA---KNFHVKAVMKTSVLLSWEIP 627



 Score =  138 bits (347), Expect = 6e-32
 Identities = 124/428 (28%), Positives = 195/428 (45%), Gaps = 37/428 (8%)

Query: 583  FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
            +   A S  G+  + A+I+ + +   P  P      T  ++TSI ++W     E  +  I
Sbjct: 297  YTCVAMSTLGVIEAIAQITVKALPKPPGTPV----VTESTATSITLTWDSGNPEPVSYYI 352

Query: 643  TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702
             ++  K       ++   EI G+   TT+Y +  L  +++Y   V A  ++G GP S  V
Sbjct: 353  IQHKPK-----NSEELYKEIDGVA--TTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 405

Query: 703  LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 762
            L +T+E  PS  PR V+   ++ST++ V W+   P + +GQI+GY+V+Y  M+  +    
Sbjct: 406  LTQTSEQAPSSAPRDVQARMLSSTTILVQWKE--PEEPNGQIQGYRVYYT-MDPTQHVNN 462

Query: 763  PMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVI 822
             M  +V  AD+Q   I  L P+ +YS+ V A+T+ GDG  S    V T   VPG+P    
Sbjct: 463  WMKHNV--ADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK 520

Query: 823  NHTQMNTA-LIQWHPP-VDTFGPLQGYRL--KFGRKDMEPLTTLEFSEKEDHFTATDIHK 878
               +  T+ L+ W PP  DT   +  Y L  K G    E   T+   E    +    +  
Sbjct: 521  AEPESETSILLSWTPPRSDT---IANYELVYKDGEHGEEQRITI---EPGTSYRLQGLKP 574

Query: 879  GASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAER 938
             + Y FRL+AR+  G G     EIS    + + F +N H +    TSV LSW+ P   E 
Sbjct: 575  NSLYYFRLAARSPQGLGAS-TAEIS-ARTMQSMFAKNFHVKAVMKTSVLLSWEIP---EN 629

Query: 939  NGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSP 998
                  + +LY D       M + +    T   +  LKP+ +Y   V  +     G    
Sbjct: 630  YNSAMPFKILYDDGK-----MVEEVDGRATQKLIVNLKPEKSYSF-VLTNRGNSAGGLQH 683

Query: 999  SVQFRTLP 1006
             V  +T P
Sbjct: 684  RVTAKTAP 691



 Score = 97.8 bits (242), Expect = 9e-20
 Identities = 138/609 (22%), Positives = 235/609 (38%), Gaps = 91/609 (14%)

Query: 41  ASFICQATGDPRPKIVWNKKGKKV--SNQRFEVIEFDDGSGSV---LRIQPLRTPRDEAI 95
           A+ +C A+G+P P+I W K    V  SN    + +   G   +   L+I+      D+  
Sbjct: 143 ATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSEES-DQGK 201

Query: 96  YECVASNNVG-EISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPD 154
           YECVA+N+ G   S    L V    ++ R  P   + P    +    +  + C A G+P 
Sbjct: 202 YECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM 261

Query: 155 PEITWF---KDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATN 211
           P + W    +D  P D                   PI G   +E ++      Y CVA +
Sbjct: 262 PYVKWMLGAEDLTPEDDM-----------------PI-GRNVLELNDVRQSANYTCVAMS 303

Query: 212 SAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCV-AVGSPMPYVKWM 270
           + G    A A + V+ L +          PP    +    + +IT     G+P P   ++
Sbjct: 304 TLGV-IEAIAQITVKALPK----------PPGTPVVTESTATSITLTWDSGNPEPVSYYI 352

Query: 271 LGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPV 330
           +  +   P++   + + +    D   +  Y+   +S     E            PP  PV
Sbjct: 353 IQHK---PKNSEELYKEI----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 405

Query: 331 VTEST-----------------ATSITLTWDSGNPEP--------VSYYIIQHKPKNSEE 365
           +T+++                 +T+I + W     EP        V Y +   +  N+  
Sbjct: 406 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNNWM 464

Query: 366 LYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQ 425
            +   D   TT   +  L P   Y  +V+A  +IG GP S  +   T    P   P + +
Sbjct: 465 KHNVADSQITT---IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNFK 520

Query: 426 ARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQ 485
           A   S T+IL+ W  P      I  Y + Y     +H     +  +       +  L P 
Sbjct: 521 AEPESETSILLSWTPPRSDT--IANYELVYK--DGEHGEE-QRITIEPGTSYRLQGLKPN 575

Query: 486 KTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRS-DTI 544
             Y  ++ A +  G G  +++I   T   +  +  NF  +   +TS+LLSW  P + ++ 
Sbjct: 576 SLYYFRLAARSPQGLGASTAEISARTMQSMFAK--NFHVKAVMKTSVLLSWEIPENYNSA 633

Query: 545 ANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAS---TAEIS 601
             ++++Y DG+  EE        T   +  LKP   Y F L  R     G     TA+ +
Sbjct: 634 MPFKILYDDGKMVEE---VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTA 690

Query: 602 ARTMQSKPS 610
              +++KP+
Sbjct: 691 PDVLRTKPA 699


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
            isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score = 1541 bits (3990), Expect = 0.0
 Identities = 796/1214 (65%), Positives = 938/1214 (77%), Gaps = 42/1214 (3%)

Query: 706  TNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPML 765
            T + +P  P   +  E   +TS+ ++W S  P+     +  Y + Y   ++    G   +
Sbjct: 318  TVKSLPKAPGTPMVTENT-ATSITITWDSGNPDP----VSYYVIEY---KSKSQDGPYQI 369

Query: 766  KDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLV-IN 823
            K+ +        I GL P + Y + V+A  + G G  S+  +  T    P   PR V   
Sbjct: 370  KEDITTTRYS--IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQAR 427

Query: 824  HTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT--DIHKGAS 881
                 T ++QW  PV+  G ++GYR+ +  +   P+   +    +D    T   + +  +
Sbjct: 428  MLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDET 487

Query: 882  YVFRLSARNKVGFGEEMVKEISIPEEVPT-----GFPQNLHSEGTTSTSVQLSWQPPVLA 936
            Y  R+ A   VG G      +S P +V T     G P NL +E  + TS+ LSW PP   
Sbjct: 488  YTVRVLAFTSVGDGP-----LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPP--- 539

Query: 937  ERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPY 996
             R   I KY LL+R+ +     + +   P  T+  +  LKP+T Y  ++ A + +G G +
Sbjct: 540  -RQESIIKYELLFREGDHGR-EVGRTFDPT-TSYVVEDLKPNTEYAFRLAARSPQGLGAF 596

Query: 997  SPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDG 1056
            +P V+ RTL    +  KNF VK +MKTSVLLSWE P+NYNS  P+KI Y+   +  +VDG
Sbjct: 597  TPVVRQRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDG 652

Query: 1057 RATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMIT 1116
            R T+KLI +LKP   Y+FVLTNRG+S GGLQ  VTA TA ++L  KP+   K + DG I 
Sbjct: 653  RTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIM 712

Query: 1117 VQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR-KRRSIRYG 1174
            V LP+  +   ++ Y+I++VPL+KSRG +F+ P  SP++M+L+EL+++ISR +RRS+R+ 
Sbjct: 713  VYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHS 772

Query: 1175 REVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYA 1233
            R++E+ +PYIAA F VLP  F  GD K YGGF N+ L+ G  YV FVLAV++ +E   +A
Sbjct: 773  RQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FA 831

Query: 1234 TSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRK----RAESD 1289
             SP+SDP    + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK K    R +S+
Sbjct: 832  ASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSE 891

Query: 1290 SRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFS 1349
             R   + NN ++  HHP DPVE+RR+NFQTPGM SHPPIPI ++A+H ERLKAND+LK S
Sbjct: 892  PRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLS 951

Query: 1350 QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDG 1409
            QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV+L  IEGI GSDY+NANY+DG
Sbjct: 952  QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDG 1011

Query: 1410 YRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHG 1469
            YR QNAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G
Sbjct: 1012 YRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYG 1071

Query: 1470 LVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRV 1529
             +QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRV
Sbjct: 1072 FIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRV 1131

Query: 1530 KTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQT 1589
            KTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQT
Sbjct: 1132 KTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQT 1191

Query: 1590 EDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHT 1649
            EDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHT
Sbjct: 1192 EDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHT 1251

Query: 1650 SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQ 1709
            SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQ
Sbjct: 1252 SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQ 1311

Query: 1710 GPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN 1769
            GPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN
Sbjct: 1312 GPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN 1371

Query: 1770 MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG 1829
            MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG
Sbjct: 1372 MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG 1431

Query: 1830 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1889
            PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+
Sbjct: 1432 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ 1491

Query: 1890 AALEYLGSFDHYAT 1903
            AALEYLGSFDHYAT
Sbjct: 1492 AALEYLGSFDHYAT 1505



 Score =  902 bits (2331), Expect = 0.0
 Identities = 448/669 (66%), Positives = 535/669 (79%), Gaps = 24/669 (3%)

Query: 20  AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
           AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29  AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88

Query: 80  SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
           +VLRIQPLRTPRDE +YECVA N+VGEI+V  +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89  AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148

Query: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
           TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS         GALQIE SEE
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS---------GALQIESSEE 199

Query: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
           +DQGKYECVATNSAG RYS+PANLYVRELREVRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200 TDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVA 259

Query: 260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319
           VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 260 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 319

Query: 320 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379
           K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ +  Y+  + + TTRYS
Sbjct: 320 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 379

Query: 380 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439
           + GLSP S+YE  V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 380 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 439

Query: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
           EP EPNG I+GYRVYYTM+P   V NW KHNV DS +TT+G+L+  +TY+V+VLAFTS+G
Sbjct: 440 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 499

Query: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559
           DGPLS  IQV TQ GVPGQP+N +AE  SETSI LSW+PPR ++I  YEL++++G+HG E
Sbjct: 500 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 559

Query: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619
              T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T  +  RT+Q   S  P++    
Sbjct: 560 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ---SISPKNFKVK 616

Query: 620 SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679
               TS+L+SW+ P  +  N   T Y I+Y  +          L +   TTK L+  L+ 
Sbjct: 617 MIMKTSVLLSWEFP--DNYNS-PTPYKIQYNGL---------TLDVDGRTTKKLITHLKP 664

Query: 680 WTEYRITVT 688
            T Y   +T
Sbjct: 665 HTFYNFVLT 673



 Score =  133 bits (335), Expect = 1e-30
 Identities = 112/403 (27%), Positives = 181/403 (44%), Gaps = 36/403 (8%)

Query: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
           +   A S  G+  + A+I+ +++   P  P      T  ++TSI ++W     +  +  +
Sbjct: 300 YTCVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITWDSGNPDPVSYYV 355

Query: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702
            EY  K        D P++I      TT+Y +  L   +EY I V+A   +G GP S SV
Sbjct: 356 IEYKSK------SQDGPYQIKE-DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESV 408

Query: 703 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 762
           + RT E  P+  PR V+   +++T++ V W  PV  + +G IRGY+V+Y  ME   P G 
Sbjct: 409 VTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRVYYT-MEPEHPVGN 465

Query: 763 PMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVI 822
               +V   D+    +  L  + +Y++ V A+T+ GDG  S P  V T   VPG+P  + 
Sbjct: 466 WQKHNV--DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLR 523

Query: 823 NHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGAS 881
              +  T++ + W PP      +  Y L F   D        F +    +   D+     
Sbjct: 524 AEARSETSITLSWSPPRQE--SIIKYELLFREGDHGREVGRTF-DPTTSYVVEDLKPNTE 580

Query: 882 YVFRLSARNKVGFG--EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERN 939
           Y FRL+AR+  G G    +V++ ++    P  F   +       TSV LSW+ P   +  
Sbjct: 581 YAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKM----IMKTSVLLSWEFP---DNY 633

Query: 940 GIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYD 982
              T Y + Y  + +        +    T   +T LKP T Y+
Sbjct: 634 NSPTPYKIQYNGLTLD-------VDGRTTKKLITHLKPHTFYN 669



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 113/473 (23%), Positives = 188/473 (39%), Gaps = 90/473 (19%)

Query: 16  LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75
           LR      PRF+  P+    + GG  +  C A G P P + W         Q  E +  +
Sbjct: 228 LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 279

Query: 76  DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135
           D       +  L   +D A Y CVA +++G I    ++TV    + P G P         
Sbjct: 280 DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 330

Query: 136 VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIE 195
           V E T T+  +   SGNPDP ++++                                 IE
Sbjct: 331 VTENTATSITITWDSGNPDP-VSYY--------------------------------VIE 357

Query: 196 QSEESDQGKYECVATNSAGTRYS-------APANLYVRELREVRRVPPRFSIPPTNHEIM 248
              +S  G Y+ +  +   TRYS       +   ++V  +  + + PP  S+     E  
Sbjct: 358 YKSKSQDGPYQ-IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQA 416

Query: 249 PGGSV-NITCVAVGSPMPYVKWMLGAED----------LTPEDDMPIG----RNV----- 288
           P  +  N+    + +    V+W    E            T E + P+G     NV     
Sbjct: 417 PASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLL 476

Query: 289 LELNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTW 343
             +  + +   YT   +A +++G       I VK     PG P+   + A   TSITL+W
Sbjct: 477 TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSW 536

Query: 344 DSGNPEP-VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRG 402
                E  + Y ++  +  +  E+ +  D   TT Y V  L P ++Y FR+ A +  G G
Sbjct: 537 SPPRQESIIKYELLFREGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLG 594

Query: 403 PPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY 455
               PV+ Q + Q  S +P++ + +M+  T++L+ W+ P+  N     Y++ Y
Sbjct: 595 -AFTPVVRQRTLQ--SISPKNFKVKMIMKTSVLLSWEFPDNYNSPTP-YKIQY 643


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
            isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score = 1541 bits (3990), Expect = 0.0
 Identities = 796/1214 (65%), Positives = 938/1214 (77%), Gaps = 42/1214 (3%)

Query: 706  TNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPML 765
            T + +P  P   +  E   +TS+ ++W S  P+     +  Y + Y   ++    G   +
Sbjct: 314  TVKSLPKAPGTPMVTENT-ATSITITWDSGNPDP----VSYYVIEY---KSKSQDGPYQI 365

Query: 766  KDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLV-IN 823
            K+ +        I GL P + Y + V+A  + G G  S+  +  T    P   PR V   
Sbjct: 366  KEDITTTRYS--IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQAR 423

Query: 824  HTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT--DIHKGAS 881
                 T ++QW  PV+  G ++GYR+ +  +   P+   +    +D    T   + +  +
Sbjct: 424  MLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDET 483

Query: 882  YVFRLSARNKVGFGEEMVKEISIPEEVPT-----GFPQNLHSEGTTSTSVQLSWQPPVLA 936
            Y  R+ A   VG G      +S P +V T     G P NL +E  + TS+ LSW PP   
Sbjct: 484  YTVRVLAFTSVGDGP-----LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPP--- 535

Query: 937  ERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPY 996
             R   I KY LL+R+ +     + +   P  T+  +  LKP+T Y  ++ A + +G G +
Sbjct: 536  -RQESIIKYELLFREGDHGR-EVGRTFDPT-TSYVVEDLKPNTEYAFRLAARSPQGLGAF 592

Query: 997  SPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDG 1056
            +P V+ RTL    +  KNF VK +MKTSVLLSWE P+NYNS  P+KI Y+   +  +VDG
Sbjct: 593  TPVVRQRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDG 648

Query: 1057 RATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMIT 1116
            R T+KLI +LKP   Y+FVLTNRG+S GGLQ  VTA TA ++L  KP+   K + DG I 
Sbjct: 649  RTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIM 708

Query: 1117 VQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR-KRRSIRYG 1174
            V LP+  +   ++ Y+I++VPL+KSRG +F+ P  SP++M+L+EL+++ISR +RRS+R+ 
Sbjct: 709  VYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHS 768

Query: 1175 REVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYA 1233
            R++E+ +PYIAA F VLP  F  GD K YGGF N+ L+ G  YV FVLAV++ +E   +A
Sbjct: 769  RQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FA 827

Query: 1234 TSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRK----RAESD 1289
             SP+SDP    + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK K    R +S+
Sbjct: 828  ASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSE 887

Query: 1290 SRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFS 1349
             R   + NN ++  HHP DPVE+RR+NFQTPGM SHPPIPI ++A+H ERLKAND+LK S
Sbjct: 888  PRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLS 947

Query: 1350 QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDG 1409
            QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV+L  IEGI GSDY+NANY+DG
Sbjct: 948  QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDG 1007

Query: 1410 YRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHG 1469
            YR QNAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G
Sbjct: 1008 YRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYG 1067

Query: 1470 LVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRV 1529
             +QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRV
Sbjct: 1068 FIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRV 1127

Query: 1530 KTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQT 1589
            KTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQT
Sbjct: 1128 KTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQT 1187

Query: 1590 EDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHT 1649
            EDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHT
Sbjct: 1188 EDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHT 1247

Query: 1650 SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQ 1709
            SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQ
Sbjct: 1248 SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQ 1307

Query: 1710 GPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN 1769
            GPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN
Sbjct: 1308 GPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN 1367

Query: 1770 MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG 1829
            MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG
Sbjct: 1368 MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG 1427

Query: 1830 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1889
            PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+
Sbjct: 1428 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ 1487

Query: 1890 AALEYLGSFDHYAT 1903
            AALEYLGSFDHYAT
Sbjct: 1488 AALEYLGSFDHYAT 1501



 Score =  889 bits (2297), Expect = 0.0
 Identities = 444/669 (66%), Positives = 531/669 (79%), Gaps = 28/669 (4%)

Query: 20  AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
           AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29  AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88

Query: 80  SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
           +VLRIQPLRTPRDE +YECVA N+VGEI+V  +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89  AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148

Query: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
           TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS         GALQIE SEE
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS---------GALQIESSEE 199

Query: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
           +DQGKYECVATNSAG RYS+PANLYVR    VRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200 TDQGKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSILPMSHEIMPGGNVNITCVA 255

Query: 260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319
           VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 256 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 315

Query: 320 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379
           K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ +  Y+  + + TTRYS
Sbjct: 316 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 375

Query: 380 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439
           + GLSP S+YE  V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 376 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 435

Query: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
           EP EPNG I+GYRVYYTM+P   V NW KHNV DS +TT+G+L+  +TY+V+VLAFTS+G
Sbjct: 436 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 495

Query: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559
           DGPLS  IQV TQ GVPGQP+N +AE  SETSI LSW+PPR ++I  YEL++++G+HG E
Sbjct: 496 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 555

Query: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619
              T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T  +  RT+Q   S  P++    
Sbjct: 556 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ---SISPKNFKVK 612

Query: 620 SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679
               TS+L+SW+ P  +  N   T Y I+Y  +          L +   TTK L+  L+ 
Sbjct: 613 MIMKTSVLLSWEFP--DNYNS-PTPYKIQYNGL---------TLDVDGRTTKKLITHLKP 660

Query: 680 WTEYRITVT 688
            T Y   +T
Sbjct: 661 HTFYNFVLT 669



 Score =  133 bits (335), Expect = 1e-30
 Identities = 112/403 (27%), Positives = 181/403 (44%), Gaps = 36/403 (8%)

Query: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
           +   A S  G+  + A+I+ +++   P  P      T  ++TSI ++W     +  +  +
Sbjct: 296 YTCVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITWDSGNPDPVSYYV 351

Query: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702
            EY  K        D P++I      TT+Y +  L   +EY I V+A   +G GP S SV
Sbjct: 352 IEYKSK------SQDGPYQIKE-DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESV 404

Query: 703 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 762
           + RT E  P+  PR V+   +++T++ V W  PV  + +G IRGY+V+Y  ME   P G 
Sbjct: 405 VTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRVYYT-MEPEHPVGN 461

Query: 763 PMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVI 822
               +V   D+    +  L  + +Y++ V A+T+ GDG  S P  V T   VPG+P  + 
Sbjct: 462 WQKHNV--DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLR 519

Query: 823 NHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGAS 881
              +  T++ + W PP      +  Y L F   D        F +    +   D+     
Sbjct: 520 AEARSETSITLSWSPPRQE--SIIKYELLFREGDHGREVGRTF-DPTTSYVVEDLKPNTE 576

Query: 882 YVFRLSARNKVGFG--EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERN 939
           Y FRL+AR+  G G    +V++ ++    P  F   +       TSV LSW+ P   +  
Sbjct: 577 YAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKM----IMKTSVLLSWEFP---DNY 629

Query: 940 GIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYD 982
              T Y + Y  + +        +    T   +T LKP T Y+
Sbjct: 630 NSPTPYKIQYNGLTLD-------VDGRTTKKLITHLKPHTFYN 665


>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
            precursor [Homo sapiens]
          Length = 802

 Score =  602 bits (1552), Expect = e-171
 Identities = 312/681 (45%), Positives = 431/681 (63%), Gaps = 13/681 (1%)

Query: 1229 SKMYATSPYSDPVVSMDLDPQPITDEEE--GLIWVVGPVLAVVFIICIVIAILLYKRKRA 1286
            S   AT+P + P  S + D +   DE     ++  +  +L +VFII ++  +   K K+A
Sbjct: 125  SSTAATTPETFPP-SGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQA 183

Query: 1287 ESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNL 1346
             S S    + N +        +P  +  L         +PP+P+ +L + I R  A+DN 
Sbjct: 184  GSHSNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNK 239

Query: 1347 KFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNAN 1405
             F +E+ ++     Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA+
Sbjct: 240  LFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINAS 299

Query: 1406 YIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGT 1465
            +I+GY+++N +IA QG   ET  DFWRMIWEQ +AT+VM+T L+ER   KC QYWP +G 
Sbjct: 300  FINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGC 359

Query: 1466 ETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTP 1521
             T+G ++V++ D   L  Y VR F + + G    R+    + QF FT+WPD GVP  P  
Sbjct: 360  WTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIG 419

Query: 1522 FLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRA 1581
             L FL++VK CNP  AG +VVHCSAGVGRTG F+VIDAML+ +  E+ VD+YG V+ +RA
Sbjct: 420  MLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRA 479

Query: 1582 QRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKR 1641
            QR  MVQT+ QY+FI+ ALLE    G+TE+   +L  ++QK+     G +  G+E EFK+
Sbjct: 480  QRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKK 539

Query: 1642 LASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQ 1701
            L S K    +  + NLP N  KNR++ I+PYE  RV +   RG E +DY+NASFIDGYRQ
Sbjct: 540  LTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQ 599

Query: 1702 QKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFV 1761
            + +YIA+QGPL  T EDFWRM+WE  S  +VMLT+L E G+EKC QYWP++    Y    
Sbjct: 600  KDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDIT 659

Query: 1762 VDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKT 1821
            V+   E     Y +R+  VT+ R+ +SR +RQF F  WPE G+P  G+G I  I  V K 
Sbjct: 660  VELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQ 719

Query: 1822 KEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTE 1881
            ++Q G + PI+VHCSAG GRTG F  LS VLER++ EG++D+FQTVK LR QRP MVQT 
Sbjct: 720  QQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTL 778

Query: 1882 DQYQFSYRAALEYLGSFDHYA 1902
            +QY+F Y+   EY+ +F  YA
Sbjct: 779  EQYEFCYKVVQEYIDAFSDYA 799


>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  601 bits (1550), Expect = e-171
 Identities = 311/679 (45%), Positives = 428/679 (63%), Gaps = 18/679 (2%)

Query: 1229 SKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAES 1288
            S   AT+P + P      D  PI      ++  +  +L +VFII ++  +   K K+A S
Sbjct: 125  SSTAATTPETFP----PSDETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGS 176

Query: 1289 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 1348
             S    + N +        +P  +  L         +PP+P+ +L + I R  A+DN  F
Sbjct: 177  HSNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLF 232

Query: 1349 SQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYI 1407
             +E+ ++     Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA++I
Sbjct: 233  REEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFI 292

Query: 1408 DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTET 1467
            +GY+++N +IA QG   ET  DFWRMIWEQ +AT+VM+T L+ER   KC QYWP +G  T
Sbjct: 293  NGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWT 352

Query: 1468 HGLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFL 1523
            +G ++V++ D   L  Y VR F + + G    R+    + QF FT+WPD GVP  P   L
Sbjct: 353  YGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGML 412

Query: 1524 AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQR 1583
             FL++VK CNP  AG +VVHCSAGVGRTG F+VIDAML+ +  E+ VD+YG V+ +RAQR
Sbjct: 413  KFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQR 472

Query: 1584 NYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLA 1643
              MVQT+ QY+FI+ ALLE    G+TE+   +L  ++QK+     G +  G+E EFK+L 
Sbjct: 473  CQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLT 532

Query: 1644 SSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQK 1703
            S K    +  + NLP N  KNR++ I+PYE  RV +   RG E +DY+NASFIDGYRQ+ 
Sbjct: 533  SIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKD 592

Query: 1704 AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVD 1763
            +YIA+QGPL  T EDFWRM+WE  S  +VMLT+L E G+EKC QYWP++    Y    V+
Sbjct: 593  SYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVE 652

Query: 1764 PMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKE 1823
               E     Y +R+  VT+ R+ +SR +RQF F  WPE G+P  G+G I  I  V K ++
Sbjct: 653  LKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQ 712

Query: 1824 QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQ 1883
            Q G + PI+VHCSAG GRTG F  LS VLER++ EG++D+FQTVK LR QRP MVQT +Q
Sbjct: 713  QSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771

Query: 1884 YQFSYRAALEYLGSFDHYA 1902
            Y+F Y+   EY+ +F  YA
Sbjct: 772  YEFCYKVVQEYIDAFSDYA 790


>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  601 bits (1550), Expect = e-171
 Identities = 311/679 (45%), Positives = 428/679 (63%), Gaps = 18/679 (2%)

Query: 1229 SKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAES 1288
            S   AT+P + P      D  PI      ++  +  +L +VFII ++  +   K K+A S
Sbjct: 125  SSTAATTPETFP----PSDETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGS 176

Query: 1289 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 1348
             S    + N +        +P  +  L         +PP+P+ +L + I R  A+DN  F
Sbjct: 177  HSNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLF 232

Query: 1349 SQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYI 1407
             +E+ ++     Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA++I
Sbjct: 233  REEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFI 292

Query: 1408 DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTET 1467
            +GY+++N +IA QG   ET  DFWRMIWEQ +AT+VM+T L+ER   KC QYWP +G  T
Sbjct: 293  NGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWT 352

Query: 1468 HGLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFL 1523
            +G ++V++ D   L  Y VR F + + G    R+    + QF FT+WPD GVP  P   L
Sbjct: 353  YGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGML 412

Query: 1524 AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQR 1583
             FL++VK CNP  AG +VVHCSAGVGRTG F+VIDAML+ +  E+ VD+YG V+ +RAQR
Sbjct: 413  KFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQR 472

Query: 1584 NYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLA 1643
              MVQT+ QY+FI+ ALLE    G+TE+   +L  ++QK+     G +  G+E EFK+L 
Sbjct: 473  CQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLT 532

Query: 1644 SSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQK 1703
            S K    +  + NLP N  KNR++ I+PYE  RV +   RG E +DY+NASFIDGYRQ+ 
Sbjct: 533  SIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKD 592

Query: 1704 AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVD 1763
            +YIA+QGPL  T EDFWRM+WE  S  +VMLT+L E G+EKC QYWP++    Y    V+
Sbjct: 593  SYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVE 652

Query: 1764 PMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKE 1823
               E     Y +R+  VT+ R+ +SR +RQF F  WPE G+P  G+G I  I  V K ++
Sbjct: 653  LKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQ 712

Query: 1824 QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQ 1883
            Q G + PI+VHCSAG GRTG F  LS VLER++ EG++D+FQTVK LR QRP MVQT +Q
Sbjct: 713  QSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771

Query: 1884 YQFSYRAALEYLGSFDHYA 1902
            Y+F Y+   EY+ +F  YA
Sbjct: 772  YEFCYKVVQEYIDAFSDYA 790


>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
            precursor [Homo sapiens]
          Length = 700

 Score =  556 bits (1433), Expect = e-158
 Identities = 294/655 (44%), Positives = 411/655 (62%), Gaps = 15/655 (2%)

Query: 1258 LIWVVGPVLAVVFIICIVIAILLYKRKR-AESDSRKSSIPNNKEIPSHHPTDPVELRRLN 1316
            L W++ P+L ++ ++ +      ++++R A   +    +PN   I        V L  L+
Sbjct: 48   LAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKMPNG--ILEEQEQQRVML--LS 103

Query: 1317 FQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKN 1375
                G   + PIP+  L + I    A+D  +F +E+ S+  G  Q T+E +N E N+ KN
Sbjct: 104  RSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKN 163

Query: 1376 RYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIW 1435
            RY N++  DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG   ET  DFWRM+W
Sbjct: 164  RYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVW 223

Query: 1436 EQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK-- 1493
            EQ+SAT+VM+T L+ER   KC QYWP +G  T+G ++V + D V L  Y +R F +    
Sbjct: 224  EQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQL 283

Query: 1494 -NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1552
             +G    R V Q  FT+WPD GVP  P   L FL++VKT NP  AGP+VVHCSAGVGRTG
Sbjct: 284  PDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTG 343

Query: 1553 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVP 1612
             FIVIDAM+  +  E+ VD++  V+ +R QR  MVQT+ QY FI+ ALLE    G+TE+ 
Sbjct: 344  TFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELD 403

Query: 1613 ARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPY 1672
              +L  ++Q +    T  +  G+E EF++L + +       + NLP N  K R++ I+PY
Sbjct: 404  VSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPY 463

Query: 1673 ESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVV 1732
            +  RV L   RG E +DYINASFIDGYRQ+  +IATQGPLA T EDFWRM+WE  S  +V
Sbjct: 464  DFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIV 523

Query: 1733 MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQ 1787
            MLT+++E  ++KC+QYWP E S  +    ++   +       +R+F VT       ++ Q
Sbjct: 524  MLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQ 583

Query: 1788 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFIT 1847
             R VRQF F  WPE G+P  G+G ID I  V K ++Q G + PI+VHCSAG GRTG FI 
Sbjct: 584  VRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIA 642

Query: 1848 LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1902
            LS +LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+   +++  F  YA
Sbjct: 643  LSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 697


>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
            [Homo sapiens]
          Length = 642

 Score =  550 bits (1416), Expect = e-156
 Identities = 282/591 (47%), Positives = 384/591 (64%), Gaps = 10/591 (1%)

Query: 1321 GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYAN 1379
            G   + PIP+  L + I    A+D  +F +E+ S+  G  Q T+E +N E N+ KNRY N
Sbjct: 50   GPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPN 109

Query: 1380 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1439
            ++  DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG   ET  DFWRM+WEQ+S
Sbjct: 110  ILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKS 169

Query: 1440 ATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK---NGS 1496
            AT+VM+T L+ER   KC QYWP +G  T+G ++V + D V L  Y +R F +     +G 
Sbjct: 170  ATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGC 229

Query: 1497 SEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIV 1556
               R V Q  FT+WPD GVP  P   L FL++VKT NP  AGP+VVHCSAGVGRTG FIV
Sbjct: 230  KAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIV 289

Query: 1557 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNL 1616
            IDAM+  +  E+ VD++  V+ +R QR  MVQT+ QY FI+ ALLE    G+TE+   +L
Sbjct: 290  IDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSL 349

Query: 1617 YAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTR 1676
              ++Q +    T  +  G+E EF++L + +       + NLP N  K R++ I+PY+  R
Sbjct: 350  EKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNR 409

Query: 1677 VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK 1736
            V L   RG E +DYINASFIDGYRQ+  +IATQGPLA T EDFWRM+WE  S  +VMLT+
Sbjct: 410  VILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTE 469

Query: 1737 LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTV 1791
            ++E  ++KC+QYWP E S  +    ++   +       +R+F VT       ++ Q R V
Sbjct: 470  VQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVV 529

Query: 1792 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1851
            RQF F  WPE G+P  G+G ID I  V K ++Q G + PI+VHCSAG GRTG FI LS +
Sbjct: 530  RQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNI 588

Query: 1852 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1902
            LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+   +++  F  YA
Sbjct: 589  LERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639


>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
            [Homo sapiens]
          Length = 1440

 Score =  509 bits (1312), Expect = e-144
 Identities = 302/766 (39%), Positives = 431/766 (56%), Gaps = 67/766 (8%)

Query: 1191 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 1245
            P  FT+GD++ Y GF N  L   + Y ++F        E+K      AT   +     + 
Sbjct: 682  PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741

Query: 1246 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH- 1304
             DP   TD    +  +   +L  VFI+ +++ IL+ K+ +  +  RK ++ N ++  +H 
Sbjct: 742  PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKL-AKKRKDAMGNTRQEMTHM 798

Query: 1305 --------------HPTDPVEL----------RRLNFQTPGMAS---------------- 1324
                          H  DP+ +          R  N      +S                
Sbjct: 799  VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP 858

Query: 1325 ------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYA 1378
                  HP I + +L  HI  +K +D+  F +EYES   GQ  +W+ +  + N+ KNRY 
Sbjct: 859  YQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYG 918

Query: 1379 NVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQR 1438
            N+IAYDHSRV+L  +E  P SDY+NANYIDGY++ + YIATQG + ET  DFWRMIW+++
Sbjct: 919  NIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQ 978

Query: 1439 SATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSE 1498
            SA +VM+T L E  RVKC +YWP   TE +G  +VT ++   LA Y VRTF L + G +E
Sbjct: 979  SACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNE 1037

Query: 1499 KREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVID 1558
             REV+QF FT WPDHGVP H T  L+F+RRVK  NPP AGP+VVHCSAG GRTGC+IVID
Sbjct: 1038 IREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVID 1097

Query: 1559 AMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYA 1618
             ML+  + E  VDIY  V  +R++R  MVQTE+QYIFIHDA+LEA  CG T +P     A
Sbjct: 1098 IMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKA 1157

Query: 1619 YIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLVNIMPYESTR 1676
                + +I++  N + ++ EF+ L S   +        A LP N  KNR ++++P +   
Sbjct: 1158 AYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCL 1217

Query: 1677 VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK 1736
              L  I G E S+YINA+ +D YRQ  A+I TQ PL  T +DFWR+++++  T +VML +
Sbjct: 1218 PFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNE 1276

Query: 1737 LREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQSRTVRQ 1793
            +     + C QYWP E   RY    V+ M+   + ++   I R   +T  ++G    V+Q
Sbjct: 1277 VDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY-LMVQQ 1333

Query: 1794 FQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVFITLSIV 1851
            FQ+  W   + VP S   F+  I QV K +E+  + +G   +HC  G GR+G+F  + IV
Sbjct: 1334 FQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIV 1393

Query: 1852 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1897
            +E ++ + VVD+F  VK LR  +P MV+  +QY+F Y  ALEYL S
Sbjct: 1394 VEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 94/444 (21%), Positives = 174/444 (39%), Gaps = 58/444 (13%)

Query: 246 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 299
           E+  G +    C+A G    + K  L   +    +D+P+ +    +N  R +A+      
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260

Query: 300 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 348
                  Y CV  S  G  +   AQ+ V+  P+P   P +     T + +  ++ +    
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320

Query: 349 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 406
            P+    ++++  +    + E   V    Y +  L P ++YE RV+       G G P  
Sbjct: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378

Query: 407 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 464
           P++T+T    P   P+ ++   + +  I V W+          GY +   +T + T   +
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430

Query: 465 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515
            +  HN + +             + +L P    S+K++  T+      S +  + T   V
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489

Query: 516 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 563
           PG  P+        E  I L+W  P   +  I  YE+ Y             G  Q ++ 
Sbjct: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549

Query: 564 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSS 623
           +   T +    L P + Y F + A + +G G +TA I+  T  S P+ P  +    S + 
Sbjct: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDYEGVDASLNE 608

Query: 624 TSILVSWQPPPVEKQNGIITEYSI 647
           T+  ++    P + +   I+ Y I
Sbjct: 609 TATTITVLLRPAQAKGAPISAYQI 632



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 86/376 (22%), Positives = 144/376 (38%), Gaps = 35/376 (9%)

Query: 569 SYRLQGLKPNSLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSIL 627
           S+RLQ +       +R   +S +G G S  A++  R    +P APPQ +       T +L
Sbjct: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE-PPRPIAPPQLLGV---GPTYLL 309

Query: 628 VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RI 685
           +      +     II +  ++Y    G   + H +     +   Y L  L+  TEY  R+
Sbjct: 310 IQLNANSIIGDGPIILK-EVEYRMTSGSWTETHAV-----NAPTYKLWHLDPDTEYEIRV 363

Query: 686 TVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIR 745
            +T   + G G     ++ RT    P   P+ +++  + +  + V W S   N       
Sbjct: 364 LLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTF 423

Query: 746 GYQV--HYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARS 803
              +  HY R  N E K   +  D     A   +++ L P T+ SL +     +G    S
Sbjct: 424 NVTICYHYFRGHN-ESKADCLDMD---PKAPQHVVNHLPPYTNVSLKMILTNPEG-RKES 478

Query: 804 KPKLVSTTGAVPGK-PRLVINHTQM-NTALIQWHPPVDTFGPLQGYRLKFGR-KDMEPLT 860
           +  ++ T   VPG  P   +  T   N   + W  P+D  G +  Y + +   +  +P  
Sbjct: 479 EETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAV 538

Query: 861 -------TLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT--- 910
                  T+       H     +H G +Y F + A    GFG      ++     PT   
Sbjct: 539 PVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPD 598

Query: 911 --GFPQNLHSEGTTST 924
             G   +L+   TT T
Sbjct: 599 YEGVDASLNETATTIT 614



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 95/420 (22%), Positives = 158/420 (37%), Gaps = 54/420 (12%)

Query: 171 NNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELRE 230
           N   I   ++++I       + ++++  ++DQ  Y CV  +  G+  S  A L VRE   
Sbjct: 234 NGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE--- 290

Query: 231 VRRVPPRFSIPPTNHEIMPGG---SVNITCVAVGSP--MPYVKWMLGAEDLTPEDDMPIG 285
               PPR   PP    + P      +N   +    P  +  V++ + +   T  +   + 
Sbjct: 291 ----PPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWT--ETHAVN 344

Query: 286 RNVLELNDVRQSANYTCVAMST--------LGVIEAIAQITVKALPKPPGTPVVTESTAT 337
               +L  +     Y    + T        L     I +       + P T  + E  A 
Sbjct: 345 APTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQAR 404

Query: 338 SITLTWDS----------GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYS 387
            I + W+S           N     +Y   H    ++ L  ++D  A  ++ V  L PY+
Sbjct: 405 RIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCL--DMDPKAP-QHVVNHLPPYT 461

Query: 388 DYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ 447
           +   +++  N  GR   SE  + QT E  P   P            I + WKEP +PNG 
Sbjct: 462 NVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGI 520

Query: 448 IQGYRVYY----TMDPTQHVNN--WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG 501
           I  Y + Y    + DP   V        N+ +S      +L P  TY   + A T  G G
Sbjct: 521 ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580

Query: 502 PLSSDIQVITQTGVPGQP--------LNFKAEPESETSILLSWTPPRSDTIANYELVYKD 553
           P ++ I V T    P  P        LN   E  +  ++LL     +   I+ Y++V ++
Sbjct: 581 PATA-INVTTNISAPTLPDYEGVDASLN---ETATTITVLLRPAQAKGAPISAYQIVVEE 636



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 58/235 (24%), Positives = 82/235 (34%), Gaps = 26/235 (11%)

Query: 781 LQPETSYSLTV--TAYTTKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWHP 836
           L P+T Y + V  T     G G    P +  T  A P +    L I   Q     + W  
Sbjct: 353 LDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES 412

Query: 837 ------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARN 890
                    TF     Y    G  + +    L+   K        +    +   ++   N
Sbjct: 413 LGYNITRCHTFNVTICYHYFRGHNESKA-DCLDMDPKAPQHVVNHLPPYTNVSLKMILTN 471

Query: 891 KVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR 950
             G  E     I   E+VP   P       +    + L+W+ P+  + NGIIT+Y + Y 
Sbjct: 472 PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYS 529

Query: 951 DINI--PLLPMEQLIVPADTTMTLTG--------LKPDTTYDVKVRAHTSKGPGP 995
            I    P +P+     P  T   L          L P TTY   +RA T KG GP
Sbjct: 530 SIRSFDPAVPVAG---PPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP 581


>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
            [Homo sapiens]
          Length = 1446

 Score =  503 bits (1295), Expect = e-142
 Identities = 302/772 (39%), Positives = 431/772 (55%), Gaps = 73/772 (9%)

Query: 1191 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 1245
            P  FT+GD++ Y GF N  L   + Y ++F        E+K      AT   +     + 
Sbjct: 682  PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741

Query: 1246 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH- 1304
             DP   TD    +  +   +L  VFI+ +++ IL+ K+ +  +  RK ++ N ++  +H 
Sbjct: 742  PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKL-AKKRKDAMGNTRQEMTHM 798

Query: 1305 --------------HPTDPVEL----------RRLNFQTPGMAS---------------- 1324
                          H  DP+ +          R  N      +S                
Sbjct: 799  VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP 858

Query: 1325 ------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYA 1378
                  HP I + +L  HI  +K +D+  F +EYES   GQ  +W+ +  + N+ KNRY 
Sbjct: 859  YQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYG 918

Query: 1379 NVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSLPETFGDFWR 1432
            N+IAYDHSRV+L  +E  P SDY+NANYID      GY++ + YIATQG + ET  DFWR
Sbjct: 919  NIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWR 978

Query: 1433 MIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALY 1492
            MIW+++SA +VM+T L E  RVKC +YWP   TE +G  +VT ++   LA Y VRTF L 
Sbjct: 979  MIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLE 1037

Query: 1493 KNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1552
            + G +E REV+QF FT WPDHGVP H T  L+F+RRVK  NPP AGP+VVHCSAG GRTG
Sbjct: 1038 RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTG 1097

Query: 1553 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVP 1612
            C+IVID ML+  + E  VDIY  V  +R++R  MVQTE+QYIFIHDA+LEA  CG T +P
Sbjct: 1098 CYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIP 1157

Query: 1613 ARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLVNIM 1670
                 A    + +I++  N + ++ EF+ L S   +        A LP N  KNR ++++
Sbjct: 1158 VCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDML 1217

Query: 1671 PYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI 1730
            P +     L  I G E S+YINA+ +D YRQ  A+I TQ PL  T +DFWR+++++  T 
Sbjct: 1218 PPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTS 1276

Query: 1731 VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQ 1787
            +VML ++     + C QYWP E   RY    V+ M+   + ++   I R   +T  ++G 
Sbjct: 1277 IVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY 1334

Query: 1788 SRTVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVF 1845
               V+QFQ+  W   + VP S   F+  I QV K +E+  + +G   +HC  G GR+G+F
Sbjct: 1335 -LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMF 1393

Query: 1846 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1897
              + IV+E ++ + VVD+F  VK LR  +P MV+  +QY+F Y  ALEYL S
Sbjct: 1394 CAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 94/444 (21%), Positives = 174/444 (39%), Gaps = 58/444 (13%)

Query: 246 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 299
           E+  G +    C+A G    + K  L   +    +D+P+ +    +N  R +A+      
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260

Query: 300 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 348
                  Y CV  S  G  +   AQ+ V+  P+P   P +     T + +  ++ +    
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320

Query: 349 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 406
            P+    ++++  +    + E   V    Y +  L P ++YE RV+       G G P  
Sbjct: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378

Query: 407 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 464
           P++T+T    P   P+ ++   + +  I V W+          GY +   +T + T   +
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430

Query: 465 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515
            +  HN + +             + +L P    S+K++  T+      S +  + T   V
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489

Query: 516 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 563
           PG  P+        E  I L+W  P   +  I  YE+ Y             G  Q ++ 
Sbjct: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549

Query: 564 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSS 623
           +   T +    L P + Y F + A + +G G +TA I+  T  S P+ P  +    S + 
Sbjct: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDYEGVDASLNE 608

Query: 624 TSILVSWQPPPVEKQNGIITEYSI 647
           T+  ++    P + +   I+ Y I
Sbjct: 609 TATTITVLLRPAQAKGAPISAYQI 632



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 86/376 (22%), Positives = 144/376 (38%), Gaps = 35/376 (9%)

Query: 569 SYRLQGLKPNSLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSIL 627
           S+RLQ +       +R   +S +G G S  A++  R    +P APPQ +       T +L
Sbjct: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE-PPRPIAPPQLLGV---GPTYLL 309

Query: 628 VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RI 685
           +      +     II +  ++Y    G   + H +     +   Y L  L+  TEY  R+
Sbjct: 310 IQLNANSIIGDGPIILK-EVEYRMTSGSWTETHAV-----NAPTYKLWHLDPDTEYEIRV 363

Query: 686 TVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIR 745
            +T   + G G     ++ RT    P   P+ +++  + +  + V W S   N       
Sbjct: 364 LLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTF 423

Query: 746 GYQV--HYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARS 803
              +  HY R  N E K   +  D     A   +++ L P T+ SL +     +G    S
Sbjct: 424 NVTICYHYFRGHN-ESKADCLDMD---PKAPQHVVNHLPPYTNVSLKMILTNPEG-RKES 478

Query: 804 KPKLVSTTGAVPGK-PRLVINHTQM-NTALIQWHPPVDTFGPLQGYRLKFGR-KDMEPLT 860
           +  ++ T   VPG  P   +  T   N   + W  P+D  G +  Y + +   +  +P  
Sbjct: 479 EETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAV 538

Query: 861 -------TLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT--- 910
                  T+       H     +H G +Y F + A    GFG      ++     PT   
Sbjct: 539 PVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPD 598

Query: 911 --GFPQNLHSEGTTST 924
             G   +L+   TT T
Sbjct: 599 YEGVDASLNETATTIT 614



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 95/420 (22%), Positives = 158/420 (37%), Gaps = 54/420 (12%)

Query: 171 NNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELRE 230
           N   I   ++++I       + ++++  ++DQ  Y CV  +  G+  S  A L VRE   
Sbjct: 234 NGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE--- 290

Query: 231 VRRVPPRFSIPPTNHEIMPGG---SVNITCVAVGSP--MPYVKWMLGAEDLTPEDDMPIG 285
               PPR   PP    + P      +N   +    P  +  V++ + +   T  +   + 
Sbjct: 291 ----PPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWT--ETHAVN 344

Query: 286 RNVLELNDVRQSANYTCVAMST--------LGVIEAIAQITVKALPKPPGTPVVTESTAT 337
               +L  +     Y    + T        L     I +       + P T  + E  A 
Sbjct: 345 APTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQAR 404

Query: 338 SITLTWDS----------GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYS 387
            I + W+S           N     +Y   H    ++ L  ++D  A  ++ V  L PY+
Sbjct: 405 RIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCL--DMDPKAP-QHVVNHLPPYT 461

Query: 388 DYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ 447
           +   +++  N  GR   SE  + QT E  P   P            I + WKEP +PNG 
Sbjct: 462 NVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGI 520

Query: 448 IQGYRVYY----TMDPTQHVNN--WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG 501
           I  Y + Y    + DP   V        N+ +S      +L P  TY   + A T  G G
Sbjct: 521 ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580

Query: 502 PLSSDIQVITQTGVPGQP--------LNFKAEPESETSILLSWTPPRSDTIANYELVYKD 553
           P ++ I V T    P  P        LN   E  +  ++LL     +   I+ Y++V ++
Sbjct: 581 PATA-INVTTNISAPTLPDYEGVDASLN---ETATTITVLLRPAQAKGAPISAYQIVVEE 636



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 58/235 (24%), Positives = 82/235 (34%), Gaps = 26/235 (11%)

Query: 781 LQPETSYSLTV--TAYTTKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWHP 836
           L P+T Y + V  T     G G    P +  T  A P +    L I   Q     + W  
Sbjct: 353 LDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES 412

Query: 837 ------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARN 890
                    TF     Y    G  + +    L+   K        +    +   ++   N
Sbjct: 413 LGYNITRCHTFNVTICYHYFRGHNESKA-DCLDMDPKAPQHVVNHLPPYTNVSLKMILTN 471

Query: 891 KVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR 950
             G  E     I   E+VP   P       +    + L+W+ P+  + NGIIT+Y + Y 
Sbjct: 472 PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYS 529

Query: 951 DINI--PLLPMEQLIVPADTTMTLTG--------LKPDTTYDVKVRAHTSKGPGP 995
            I    P +P+     P  T   L          L P TTY   +RA T KG GP
Sbjct: 530 SIRSFDPAVPVAG---PPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP 581


>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
            precursor [Homo sapiens]
          Length = 1452

 Score =  498 bits (1282), Expect = e-140
 Identities = 266/580 (45%), Positives = 357/580 (61%), Gaps = 12/580 (2%)

Query: 1325 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1384
            HP I + +L  HI ++K  +   F +EYES   GQ   W+ +  + N+ KNRY N+IAYD
Sbjct: 877  HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYD 936

Query: 1385 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1444
            HSRV L  IEG   SDY+N NYIDGY + N YIATQG + ET  DFWRM+W + +A+++M
Sbjct: 937  HSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 996

Query: 1445 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1504
            +T L E  RVKC +YWP   TE +  ++VTL++T  LA Y +RTFA+ K G  E RE+RQ
Sbjct: 997  VTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQ 1055

Query: 1505 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1564
            F FT WPDHGVP H T  L F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+  
Sbjct: 1056 FHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMA 1115

Query: 1565 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1624
            + E  VDIY  V  +R++R  MVQTE+QY+FIHDA+LEA  CG+T VPA  + +    + 
Sbjct: 1116 EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMN 1175

Query: 1625 QIETGENVTGMELEFKRL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1682
            +++   N + ++ EF+ L   +          A LP N  KNR ++I+P +     L  I
Sbjct: 1176 KLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI 1235

Query: 1683 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1742
             G E S+YINA+ +D Y+Q  A+I TQ PL  T +DFWR++ +++ T VVML  +     
Sbjct: 1236 DG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--A 1292

Query: 1743 EKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1799
            + C QYWP     R    Q   V    E ++   I R +     +DG  R V+QFQF  W
Sbjct: 1293 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGW 1351

Query: 1800 P-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1857
            P  +  P S   F+  I QV K +E++ G +G   VHC  G GR+G F  +SIV E +R+
Sbjct: 1352 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1411

Query: 1858 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1897
            +  VD+F  VK LR  +P MV   DQY+F Y  ALEYL S
Sbjct: 1412 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1451



 Score =  137 bits (344), Expect = 1e-31
 Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)

Query: 1371 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1430
            N  KNR  +++  D     L  I+G   S+Y+NA  +D Y++ +A+I TQ  LP T  DF
Sbjct: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271

Query: 1431 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1490
            WR++ +    +VVM+  ++      C QYWP  G   HG +QV  +          R F 
Sbjct: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329

Query: 1491 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1544
            +Y     +   R V+QFQF  WP +   P     FL  +R+V           G  VVHC
Sbjct: 1330 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1389

Query: 1545 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1604
              G GR+G F  I  + E ++H++TVD++  V  +R  +  MV   DQY F ++  LE +
Sbjct: 1390 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1449

Query: 1605 TCG 1607
              G
Sbjct: 1450 NSG 1452



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 78/344 (22%), Positives = 126/344 (36%), Gaps = 30/344 (8%)

Query: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
           +R   R+  G+G S            P APPQ     S  +T + +      +     I+
Sbjct: 258 YRCMIRTEGGVGISNYAELVVKEPPVPIAPPQ---LASVGATYLWIQLNANSINGDGPIV 314

Query: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPESL 700
                  TA    +D+       P D+T Y +  L+  TEY I+V  T   + G G    
Sbjct: 315 AREVEYCTASGSWNDRQ------PVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGP 368

Query: 701 SVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPK 760
           ++  RT    P   PRK+EV  V S  + + W     N          VHY     G   
Sbjct: 369 ALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGG--- 425

Query: 761 GQPMLKDVMLADAQDM----IISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 816
            Q  +++ +  D ++      I+ L P T+ S+ +     +G    S+  +V T   +PG
Sbjct: 426 -QEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-KESQELIVQTDEDLPG 483

Query: 817 K--PRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGR-KDMEPLTTLEFSE------- 866
                 +   T      +QW  P  T+G +  Y + +      +P   L           
Sbjct: 484 AVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLG 543

Query: 867 KEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 910
            E HF    ++ G +Y F + A    GFG     + +     P+
Sbjct: 544 NETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPS 587



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 102/438 (23%), Positives = 167/438 (38%), Gaps = 41/438 (9%)

Query: 244 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 294
           N E+  G      C A+G  +   +  L   D+   P  ++ +    R +   N V    
Sbjct: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252

Query: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 350
           R +  Y C+  +  GV I   A++ VK  P P   P +    AT   I L  +S N + P
Sbjct: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312

Query: 351 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 408
           +    +++   +    + +   V +T Y +  L P ++YE  V+       G G P   +
Sbjct: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370

Query: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 464
            T+T    P   PR ++   + S  I ++W+       +   Y +     Y +   + V 
Sbjct: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430

Query: 465 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 522
             +  +  +S    TI NL P    SVK++     G    S ++ V T   +PG  P   
Sbjct: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489

Query: 523 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 569
                 E  I L W  P      I  YE+ YK             + G   ++  E  T 
Sbjct: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547

Query: 570 YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 629
           +   GL P + Y F + A + +G G   A     T  S PS P  ++  T  + T   V+
Sbjct: 548 FLFFGLYPGTTYSFTIRASTAKGFG-PPATNQFTTKISAPSMPAYELE-TPLNQTDNTVT 605

Query: 630 WQPPPVEKQNGIITEYSI 647
               P   +   ++ Y I
Sbjct: 606 VMLKPAHSRGAPVSVYQI 623



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 93/436 (21%), Positives = 165/436 (37%), Gaps = 61/436 (13%)

Query: 191 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEI-MP 249
           +  +  + + D GKY C+     G   S  A L V+E       P   S+  T   I + 
Sbjct: 244 SFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLN 303

Query: 250 GGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL- 308
             S+N     V   + Y          +  D  P+     ++  +     Y    + T  
Sbjct: 304 ANSINGDGPIVAREVEYC-----TASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRP 358

Query: 309 ------GVIEAIAQITVKALP-KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPK 361
                     A+   T  A P + P    V E  +  IT+ W     EP  Y + +    
Sbjct: 359 GEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRW-----EPFGYNVTRCHSY 413

Query: 362 N-----------SEELYKEIDGVATT---RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEP 407
           N            E++ +E+         ++++  LSPY++   +++ +N  GR   S+ 
Sbjct: 414 NLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-KESQE 472

Query: 408 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHV 463
           ++ QT E  P + P +          I +QW+EP +  G I  Y + Y    + DP   +
Sbjct: 473 LIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDL 532

Query: 464 NNWMKHNVADSQITTIGN--------LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515
           +N         +++ +GN        L P  TYS  + A T+ G GP +++ Q  T+   
Sbjct: 533 SN------QSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTTKISA 585

Query: 516 PGQPLNFKAEPESET----SILLSWTPPRSDTIANYELVYKDGEHGEEQRIT----IEPG 567
           P  P      P ++T    +++L     R   ++ Y++V ++      ++ T      P 
Sbjct: 586 PSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPV 645

Query: 568 TSYRLQGLKPNSLYYF 583
             +       NS YYF
Sbjct: 646 PIHFQNASLLNSQYYF 661



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 77/342 (22%), Positives = 127/342 (37%), Gaps = 36/342 (10%)

Query: 682  EYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQH 741
            +YR  +   T+ G G  + + L+     VP  PP   ++ +V +T + +   +   N   
Sbjct: 257  KYRCMI--RTEGGVGISNYAELVVKEPPVPIAPP---QLASVGATYLWIQLNANSINGD- 310

Query: 742  GQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGA 801
            G I   +V Y          QP+       D+    I  L P+T Y ++V   T  G+G 
Sbjct: 311  GPIVAREVEYCTASGSWNDRQPV-------DSTSYKIGHLDPDTEYEISVLL-TRPGEGG 362

Query: 802  RSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKF----- 851
               P     T       + G  +L +   +     I+W P          Y L       
Sbjct: 363  TGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQ 422

Query: 852  --GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVP 909
              G++ +    + +        T T++    +   +L   N  G  E     +   E++P
Sbjct: 423  VGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLP 482

Query: 910  TGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-----DINIPLLPMEQLI- 963
               P       T    + L W+ P   +  G+IT Y + Y+     D  I L      + 
Sbjct: 483  GAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS 540

Query: 964  -VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1004
             +  +T     GL P TTY   +RA T+KG GP + + QF T
Sbjct: 541  KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 78/366 (21%), Positives = 139/366 (37%), Gaps = 64/366 (17%)

Query: 971  TLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVMKT 1023
            T+T L P T   VK+     +G    S  +  +T       +P + +    F  K     
Sbjct: 445  TITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTESIQGSTFEEK----- 498

Query: 1024 SVLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEK 1070
             + L W  P + Y     ++I Y      + E+D           G  T  L   L P  
Sbjct: 499  -IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGT 557

Query: 1071 SYSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVP 1123
            +YSF +   T +G          T  +AP +    PA+  +T L   D  +TV L P   
Sbjct: 558  TYSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHS 613

Query: 1124 ANENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVEL 1179
                +  Y I++   +  R K     +K +  P   +   LL                  
Sbjct: 614  RGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS---------------- 657

Query: 1180 KPYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYAT 1234
            + Y AA F     +    FT+GD+K Y G+ N  L   + Y ++F  A   + E+K+   
Sbjct: 658  QYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCV 717

Query: 1235 SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSS 1294
               +    +    P+P   + +  + + G +  ++  + I + ++L  +KR  +  RK +
Sbjct: 718  QVATKGAATPKPVPEP-EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKET 776

Query: 1295 IPNNKE 1300
            + + ++
Sbjct: 777  MSSTRQ 782


>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
            precursor [Homo sapiens]
          Length = 1465

 Score =  498 bits (1282), Expect = e-140
 Identities = 266/580 (45%), Positives = 357/580 (61%), Gaps = 12/580 (2%)

Query: 1325 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1384
            HP I + +L  HI ++K  +   F +EYES   GQ   W+ +  + N+ KNRY N+IAYD
Sbjct: 890  HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYD 949

Query: 1385 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1444
            HSRV L  IEG   SDY+N NYIDGY + N YIATQG + ET  DFWRM+W + +A+++M
Sbjct: 950  HSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 1009

Query: 1445 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1504
            +T L E  RVKC +YWP   TE +  ++VTL++T  LA Y +RTFA+ K G  E RE+RQ
Sbjct: 1010 VTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQ 1068

Query: 1505 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1564
            F FT WPDHGVP H T  L F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+  
Sbjct: 1069 FHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMA 1128

Query: 1565 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1624
            + E  VDIY  V  +R++R  MVQTE+QY+FIHDA+LEA  CG+T VPA  + +    + 
Sbjct: 1129 EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMN 1188

Query: 1625 QIETGENVTGMELEFKRL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1682
            +++   N + ++ EF+ L   +          A LP N  KNR ++I+P +     L  I
Sbjct: 1189 KLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI 1248

Query: 1683 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1742
             G E S+YINA+ +D Y+Q  A+I TQ PL  T +DFWR++ +++ T VVML  +     
Sbjct: 1249 DG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--A 1305

Query: 1743 EKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1799
            + C QYWP     R    Q   V    E ++   I R +     +DG  R V+QFQF  W
Sbjct: 1306 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGW 1364

Query: 1800 P-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1857
            P  +  P S   F+  I QV K +E++ G +G   VHC  G GR+G F  +SIV E +R+
Sbjct: 1365 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1424

Query: 1858 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1897
            +  VD+F  VK LR  +P MV   DQY+F Y  ALEYL S
Sbjct: 1425 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464



 Score =  137 bits (344), Expect = 1e-31
 Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)

Query: 1371 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1430
            N  KNR  +++  D     L  I+G   S+Y+NA  +D Y++ +A+I TQ  LP T  DF
Sbjct: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284

Query: 1431 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1490
            WR++ +    +VVM+  ++      C QYWP  G   HG +QV  +          R F 
Sbjct: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342

Query: 1491 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1544
            +Y     +   R V+QFQF  WP +   P     FL  +R+V           G  VVHC
Sbjct: 1343 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1402

Query: 1545 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1604
              G GR+G F  I  + E ++H++TVD++  V  +R  +  MV   DQY F ++  LE +
Sbjct: 1403 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1462

Query: 1605 TCG 1607
              G
Sbjct: 1463 NSG 1465



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 78/344 (22%), Positives = 126/344 (36%), Gaps = 30/344 (8%)

Query: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
           +R   R+  G+G S            P APPQ     S  +T + +      +     I+
Sbjct: 258 YRCMIRTEGGVGISNYAELVVKEPPVPIAPPQ---LASVGATYLWIQLNANSINGDGPIV 314

Query: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPESL 700
                  TA    +D+       P D+T Y +  L+  TEY I+V  T   + G G    
Sbjct: 315 AREVEYCTASGSWNDRQ------PVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGP 368

Query: 701 SVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPK 760
           ++  RT    P   PRK+EV  V S  + + W     N          VHY     G   
Sbjct: 369 ALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGG--- 425

Query: 761 GQPMLKDVMLADAQDM----IISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 816
            Q  +++ +  D ++      I+ L P T+ S+ +     +G    S+  +V T   +PG
Sbjct: 426 -QEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-KESQELIVQTDEDLPG 483

Query: 817 K--PRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGR-KDMEPLTTLEFSE------- 866
                 +   T      +QW  P  T+G +  Y + +      +P   L           
Sbjct: 484 AVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLG 543

Query: 867 KEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 910
            E HF    ++ G +Y F + A    GFG     + +     P+
Sbjct: 544 NETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPS 587



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 102/438 (23%), Positives = 167/438 (38%), Gaps = 41/438 (9%)

Query: 244 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 294
           N E+  G      C A+G  +   +  L   D+   P  ++ +    R +   N V    
Sbjct: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252

Query: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 350
           R +  Y C+  +  GV I   A++ VK  P P   P +    AT   I L  +S N + P
Sbjct: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312

Query: 351 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 408
           +    +++   +    + +   V +T Y +  L P ++YE  V+       G G P   +
Sbjct: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370

Query: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 464
            T+T    P   PR ++   + S  I ++W+       +   Y +     Y +   + V 
Sbjct: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430

Query: 465 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 522
             +  +  +S    TI NL P    SVK++     G    S ++ V T   +PG  P   
Sbjct: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489

Query: 523 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 569
                 E  I L W  P      I  YE+ YK             + G   ++  E  T 
Sbjct: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547

Query: 570 YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 629
           +   GL P + Y F + A + +G G   A     T  S PS P  ++  T  + T   V+
Sbjct: 548 FLFFGLYPGTTYSFTIRASTAKGFG-PPATNQFTTKISAPSMPAYELE-TPLNQTDNTVT 605

Query: 630 WQPPPVEKQNGIITEYSI 647
               P   +   ++ Y I
Sbjct: 606 VMLKPAHSRGAPVSVYQI 623



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 93/436 (21%), Positives = 165/436 (37%), Gaps = 61/436 (13%)

Query: 191 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEI-MP 249
           +  +  + + D GKY C+     G   S  A L V+E       P   S+  T   I + 
Sbjct: 244 SFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLN 303

Query: 250 GGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL- 308
             S+N     V   + Y          +  D  P+     ++  +     Y    + T  
Sbjct: 304 ANSINGDGPIVAREVEYC-----TASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRP 358

Query: 309 ------GVIEAIAQITVKALP-KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPK 361
                     A+   T  A P + P    V E  +  IT+ W     EP  Y + +    
Sbjct: 359 GEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRW-----EPFGYNVTRCHSY 413

Query: 362 N-----------SEELYKEIDGVATT---RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEP 407
           N            E++ +E+         ++++  LSPY++   +++ +N  GR   S+ 
Sbjct: 414 NLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-KESQE 472

Query: 408 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHV 463
           ++ QT E  P + P +          I +QW+EP +  G I  Y + Y    + DP   +
Sbjct: 473 LIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDL 532

Query: 464 NNWMKHNVADSQITTIGN--------LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515
           +N         +++ +GN        L P  TYS  + A T+ G GP +++ Q  T+   
Sbjct: 533 SN------QSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTTKISA 585

Query: 516 PGQPLNFKAEPESET----SILLSWTPPRSDTIANYELVYKDGEHGEEQRIT----IEPG 567
           P  P      P ++T    +++L     R   ++ Y++V ++      ++ T      P 
Sbjct: 586 PSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPV 645

Query: 568 TSYRLQGLKPNSLYYF 583
             +       NS YYF
Sbjct: 646 PIHFQNASLLNSQYYF 661



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 77/342 (22%), Positives = 127/342 (37%), Gaps = 36/342 (10%)

Query: 682  EYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQH 741
            +YR  +   T+ G G  + + L+     VP  PP   ++ +V +T + +   +   N   
Sbjct: 257  KYRCMI--RTEGGVGISNYAELVVKEPPVPIAPP---QLASVGATYLWIQLNANSINGD- 310

Query: 742  GQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGA 801
            G I   +V Y          QP+       D+    I  L P+T Y ++V   T  G+G 
Sbjct: 311  GPIVAREVEYCTASGSWNDRQPV-------DSTSYKIGHLDPDTEYEISVLL-TRPGEGG 362

Query: 802  RSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKF----- 851
               P     T       + G  +L +   +     I+W P          Y L       
Sbjct: 363  TGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQ 422

Query: 852  --GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVP 909
              G++ +    + +        T T++    +   +L   N  G  E     +   E++P
Sbjct: 423  VGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLP 482

Query: 910  TGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-----DINIPLLPMEQLI- 963
               P       T    + L W+ P   +  G+IT Y + Y+     D  I L      + 
Sbjct: 483  GAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS 540

Query: 964  -VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1004
             +  +T     GL P TTY   +RA T+KG GP + + QF T
Sbjct: 541  KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 78/366 (21%), Positives = 139/366 (37%), Gaps = 64/366 (17%)

Query: 971  TLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVMKT 1023
            T+T L P T   VK+     +G    S  +  +T       +P + +    F  K     
Sbjct: 445  TITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTESIQGSTFEEK----- 498

Query: 1024 SVLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEK 1070
             + L W  P + Y     ++I Y      + E+D           G  T  L   L P  
Sbjct: 499  -IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGT 557

Query: 1071 SYSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVP 1123
            +YSF +   T +G          T  +AP +    PA+  +T L   D  +TV L P   
Sbjct: 558  TYSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHS 613

Query: 1124 ANENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVEL 1179
                +  Y I++   +  R K     +K +  P   +   LL                  
Sbjct: 614  RGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS---------------- 657

Query: 1180 KPYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYAT 1234
            + Y AA F     +    FT+GD+K Y G+ N  L   + Y ++F  A   + E+K+   
Sbjct: 658  QYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCV 717

Query: 1235 SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSS 1294
               +    +    P+P   + +  + + G +  ++  + I + ++L  +KR  +  RK +
Sbjct: 718  QVATKGAATPKPVPEP-EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKET 776

Query: 1295 IPNNKE 1300
            + + ++
Sbjct: 777  MSSTRQ 782


>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
            precursor [Homo sapiens]
          Length = 1441

 Score =  495 bits (1275), Expect = e-139
 Identities = 354/1096 (32%), Positives = 535/1096 (48%), Gaps = 146/1096 (13%)

Query: 909  PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT 968
            P   PQN+      +  + L W+P   A         T+ Y+ +        + ++   +
Sbjct: 386  PVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSS 445

Query: 969  TMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVM 1021
              TL GL+P  T  +++     +G    S  +  +T       +P++ +    F  K   
Sbjct: 446  HYTLRGLRPFMTIRLRLLLSNPEGRME-SEELVVQTEEDVPGAVPLESIQGGPFEEK--- 501

Query: 1022 KTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA---------------TQKLIVN 1065
               + + W+ P   N  +  ++I Y   K V  +D  A               T  L V 
Sbjct: 502  ---IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADLSSQRGKVFKLRNETHHLFVG 555

Query: 1066 LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPAFIGKTNL---DGMITVQLPE 1121
            L P  +YSF +  + ++A G    VT + A  +   + P +   T L   D  ITV L  
Sbjct: 556  LYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKP 613

Query: 1122 VPANENIKGYYIIIVP---LKKSRGK------FIKPWESPDEMELDELLKEISRKRRSIR 1172
              +       Y ++V    L+KSR        F  P    +   LD L            
Sbjct: 614  AQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSL------------ 661

Query: 1173 YGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKM 1231
            +    ELKP   A+  V    FT+GD+K Y G+ N  L   + Y ++F      + E+K+
Sbjct: 662  HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKI 717

Query: 1232 YAT---SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKR--- 1285
                  +  +    S  ++P+   D    +  V+  +L  +FII ++  +L  KR+R   
Sbjct: 718  NCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLL--MFIIILLGVMLTIKRRRNAY 775

Query: 1286 ----------------------------AESDSRKSSIPNNKE----------------- 1300
                                        A+  + K S   N E                 
Sbjct: 776  SYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSR 835

Query: 1301 ---------IPSH--HPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFS 1349
                     I +H     DPVE+       P     P I + +L  HI ++K      F 
Sbjct: 836  GELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIRVADLLQHITQMKRGQGYGFK 890

Query: 1350 QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDG 1409
            +EYE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV L  ++G P SDY+NANYIDG
Sbjct: 891  EEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDG 950

Query: 1410 YRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHG 1469
            Y +   YIATQG + ET  DFWRMIW++ SA++VM+T L E  RVKC +YWP   TE +G
Sbjct: 951  YHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYG 1009

Query: 1470 LVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRV 1529
             ++VTL++T  LA Y +RTF + K G  E RE+R F FT+WPDHGVP + T  L F+R+V
Sbjct: 1010 DIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQV 1069

Query: 1530 KTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQT 1589
            K  NPP+AGP+VVHCSAG GRTGCFI ID ML+  ++E  VDI+  V  +RAQR  +VQT
Sbjct: 1070 KFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQT 1129

Query: 1590 EDQYIFIHDALLEAVTCGNTEVPA---RNLYAYIQKLTQIETGENVTGMELEFKRLASSK 1646
            E+QY+F+HDA+LEA  CGNT +P    R+LY  I +L   +T  +    E +   + + +
Sbjct: 1130 EEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDP-QTNSSQIKDEFQTLNIVTPR 1188

Query: 1647 AHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYI 1706
                      LP N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++
Sbjct: 1189 VRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFV 1247

Query: 1707 ATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA 1766
             TQ PL  T  DFWR+++++N + VVML ++     + C QYWP + S  Y    V+ ++
Sbjct: 1248 VTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVS 1305

Query: 1767 EYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKE 1823
                   I R F++ +    Q   R V+  Q+  WP  +  P S    +  + ++ K +E
Sbjct: 1306 ADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQE 1365

Query: 1824 QF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED 1882
            Q+ G++G   VHC  G GR+G F  +  V E ++ + ++D+F  VK LR  +  MV+T +
Sbjct: 1366 QYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLE 1425

Query: 1883 QYQFSYRAALEYLGSF 1898
            QY+F Y  ALEYL SF
Sbjct: 1426 QYKFVYEVALEYLSSF 1441



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 93/378 (24%), Positives = 152/378 (40%), Gaps = 36/378 (9%)

Query: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 351
           R  + Y CV  S  G  +   A++ VK  P P   P   E  A   T  W   N   +  
Sbjct: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316

Query: 352 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 407
                + + + + +   + E   V +  Y +  L P  +YE RV+       G GPP  P
Sbjct: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376

Query: 408 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 466
           + T+T    P   P++V+   + +  + +QW    EP G  +     Y      Q+V N 
Sbjct: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432

Query: 467 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 520
            ++     +  S   T+  L P  T  +++L   S  +G + S+  V+ T+  VPG  PL
Sbjct: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490

Query: 521 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 573
                   E  I + W PP   +  I  YE+ YK  G       ++ + G  ++L+    
Sbjct: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550

Query: 574 ----GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 629
               GL P + Y F + A + +G G       A T  S PS P  D   T  + T   ++
Sbjct: 551 HLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIA-TKISAPSMPEYDTD-TPLNETDTTIT 608

Query: 630 WQPPPVEKQNGIITEYSI 647
               P + +   ++ Y +
Sbjct: 609 VMLKPAQSRGAPVSVYQL 626



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 83/353 (23%), Positives = 137/353 (38%), Gaps = 30/353 (8%)

Query: 379 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438
           SVA  +  S  ++R V  ++ G G  +   L       P + P       L +      W
Sbjct: 253 SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306

Query: 439 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 496
            +P   +    G  +   ++       W + ++ DS    + +L P   Y ++VL     
Sbjct: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366

Query: 497 SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 547
             G GP    +   T+   P   P N +        + L W P           +    Y
Sbjct: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426

Query: 548 ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607
           + V+   ++  E+   I+  + Y L+GL+P      RL   +P+G   S  E+  +T + 
Sbjct: 427 QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE-ELVVQTEED 483

Query: 608 KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGED------DKPHE 661
            P A P +     P    I + W+PP   + NG+IT Y I Y AV   D       +  +
Sbjct: 484 VPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLDPSADLSSQRGK 541

Query: 662 ILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 714
           +  + ++ T +L   L   T Y  T+ A T  G GP  ++  I T    PS P
Sbjct: 542 VFKLRNE-THHLFVGLYPGTTYSFTIKASTAKGFGP-PVTTRIATKISAPSMP 592



 Score = 65.5 bits (158), Expect = 5e-10
 Identities = 82/336 (24%), Positives = 127/336 (37%), Gaps = 43/336 (12%)

Query: 681 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK- 739
           ++YR  +   +D G G  + + LI      P  PP   E+ AV +T +   W  P  N  
Sbjct: 263 SKYRCVI--RSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL---WIKPNANSI 314

Query: 740 -QHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKG 798
              G I   +V Y R   G         +  + D+ +  +  L P+  Y + V   T  G
Sbjct: 315 IGDGPIILKEVEY-RTTTGT------WAETHIVDSPNYKLWHLDPDVEYEIRVLL-TRPG 366

Query: 799 DGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHP------PVDTFGPLQGY 847
           +G    P    TT       V G   + I   +     +QW P         ++     Y
Sbjct: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426

Query: 848 RLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEE 907
           +  F ++  E    ++ S    H+T   +    +   RL   N  G  E     +   E+
Sbjct: 427 QYVFNQQQYEAEEVIQTSS---HYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEED 483

Query: 908 VPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLI---- 963
           VP   P      G     + + W+PP   E NG+IT Y + Y+ +   L P   L     
Sbjct: 484 VPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVG-SLDPSADLSSQRG 540

Query: 964 ----VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 995
               +  +T     GL P TTY   ++A T+KG GP
Sbjct: 541 KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGP 576



 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 88/400 (22%), Positives = 152/400 (38%), Gaps = 57/400 (14%)

Query: 579 SLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTS------PSSTSILVSWQ 631
           S+  +R   RS  G G S  AE+  +   + P APP+ ++  +      P++ SI+    
Sbjct: 261 SVSKYRCVIRSDGGSGVSNYAELIVKEPPT-PIAPPELLAVGATYLWIKPNANSII---- 315

Query: 632 PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RITVTA 689
                  +G I    ++Y    G   + H +     D+  Y L  L+   EY  R+ +T 
Sbjct: 316 ------GDGPIILKEVEYRTTTGTWAETHIV-----DSPNYKLWHLDPDVEYEIRVLLTR 364

Query: 690 HTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWR--SPVPNKQHGQIRGY 747
             + G GP    +  RT    P   P+ VE+  + +  + + W        + H      
Sbjct: 365 PGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTV 424

Query: 748 QVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKL 807
           Q  YV  +      Q    + ++  +    + GL+P  +  L +     +G    S+  +
Sbjct: 425 QYQYVFNQ------QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGR-MESEELV 477

Query: 808 VSTTGAVPGKPRL--VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRK-DMEPLTTLEF 864
           V T   VPG   L  +          IQW PP +T G +  Y + +     ++P   L  
Sbjct: 478 VQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSS 537

Query: 865 SE-------KEDHFTATDIHKGASYVFRLSARNKVGFG----EEMVKEISIPE--EVPTG 911
                     E H     ++ G +Y F + A    GFG      +  +IS P   E  T 
Sbjct: 538 QRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTD 597

Query: 912 FPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 951
            P N      T T++ +  +P     R   ++ Y L+ ++
Sbjct: 598 TPLN-----ETDTTITVMLKP--AQSRGAPVSVYQLVVKE 630


>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
            precursor [Homo sapiens]
          Length = 1460

 Score =  490 bits (1261), Expect = e-138
 Identities = 356/1115 (31%), Positives = 536/1115 (48%), Gaps = 165/1115 (14%)

Query: 909  PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT 968
            P   PQN+      +  + L W+P   A         T+ Y+ +        + ++   +
Sbjct: 386  PVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSS 445

Query: 969  TMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVM 1021
              TL GL+P  T  +++     +G    S  +  +T       +P++ +    F  K   
Sbjct: 446  HYTLRGLRPFMTIRLRLLLSNPEGRME-SEELVVQTEEDVPGAVPLESIQGGPFEEK--- 501

Query: 1022 KTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA---------------TQKLIVN 1065
               + + W+ P   N  +  ++I Y   K V  +D  A               T  L V 
Sbjct: 502  ---IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADLSSQRGKVFKLRNETHHLFVG 555

Query: 1066 LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPAFIGKTNL---DGMITVQLPE 1121
            L P  +YSF +  + ++A G    VT + A  +   + P +   T L   D  ITV L  
Sbjct: 556  LYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKP 613

Query: 1122 VPANENIKGYYIIIVP---LKKSRGK------FIKPWESPDEMELDELLKEISRKRRSIR 1172
              +       Y ++V    L+KSR        F  P    +   LD L            
Sbjct: 614  AQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSL------------ 661

Query: 1173 YGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKM 1231
            +    ELKP   A+  V    FT+GD+K Y G+ N  L   + Y ++F      + E+K+
Sbjct: 662  HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKI 717

Query: 1232 YAT-----SPYSDPVV-----------------SMDLDPQPITDEEEGLIWVVGPVLAVV 1269
                    +P     V                 S  ++P+   D    +  V+  +L  +
Sbjct: 718  NCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLL--M 775

Query: 1270 FIICIVIAILLYKRKR-------------------------------AESDSRKSSIPNN 1298
            FII ++  +L  KR+R                               A+  + K S   N
Sbjct: 776  FIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRN 835

Query: 1299 KE--------------------------IPSH--HPTDPVELRRLNFQTPGMASHPPIPI 1330
             E                          I +H     DPVE+       P     P I +
Sbjct: 836  DEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIRV 890

Query: 1331 LELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLL 1390
             +L  HI ++K      F +EYE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV L
Sbjct: 891  ADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRL 950

Query: 1391 SAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEE 1450
              ++G P SDY+NANYIDGY +   YIATQG + ET  DFWRMIW++ SA++VM+T L E
Sbjct: 951  LVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVE 1010

Query: 1451 RSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAW 1510
              RVKC +YWP   TE +G ++VTL++T  LA Y +RTF + K G  E RE+R F FT+W
Sbjct: 1011 VGRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSW 1069

Query: 1511 PDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTV 1570
            PDHGVP + T  L F+R+VK  NPP+AGP+VVHCSAG GRTGCFI ID ML+  ++E  V
Sbjct: 1070 PDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVV 1129

Query: 1571 DIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA---RNLYAYIQKLTQIE 1627
            DI+  V  +RAQR  +VQTE+QY+F+HDA+LEA  CGNT +P    R+LY  I +L   +
Sbjct: 1130 DIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDP-Q 1188

Query: 1628 TGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG 1687
            T  +    E +   + + +          LP N  KNR ++++P +     L  + G E 
Sbjct: 1189 TNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ES 1247

Query: 1688 SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQ 1747
            S+YINA+ +D ++Q  A++ TQ PL  T  DFWR+++++N + VVML ++     + C Q
Sbjct: 1248 SNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQ 1305

Query: 1748 YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGV 1804
            YWP + S  Y    V+ ++       I R F++ +    Q   R V+  Q+  WP  +  
Sbjct: 1306 YWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDT 1365

Query: 1805 PKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDI 1863
            P S    +  + ++ K +EQ+ G++G   VHC  G GR+G F  +  V E ++ + ++D+
Sbjct: 1366 PPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDV 1425

Query: 1864 FQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF 1898
            F  VK LR  +  MV+T +QY+F Y  ALEYL SF
Sbjct: 1426 FHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1460



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 93/378 (24%), Positives = 152/378 (40%), Gaps = 36/378 (9%)

Query: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 351
           R  + Y CV  S  G  +   A++ VK  P P   P   E  A   T  W   N   +  
Sbjct: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316

Query: 352 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 407
                + + + + +   + E   V +  Y +  L P  +YE RV+       G GPP  P
Sbjct: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376

Query: 408 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 466
           + T+T    P   P++V+   + +  + +QW    EP G  +     Y      Q+V N 
Sbjct: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432

Query: 467 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 520
            ++     +  S   T+  L P  T  +++L   S  +G + S+  V+ T+  VPG  PL
Sbjct: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490

Query: 521 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 573
                   E  I + W PP   +  I  YE+ YK  G       ++ + G  ++L+    
Sbjct: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550

Query: 574 ----GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 629
               GL P + Y F + A + +G G       A T  S PS P  D   T  + T   ++
Sbjct: 551 HLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIA-TKISAPSMPEYDTD-TPLNETDTTIT 608

Query: 630 WQPPPVEKQNGIITEYSI 647
               P + +   ++ Y +
Sbjct: 609 VMLKPAQSRGAPVSVYQL 626



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 83/353 (23%), Positives = 137/353 (38%), Gaps = 30/353 (8%)

Query: 379 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438
           SVA  +  S  ++R V  ++ G G  +   L       P + P       L +      W
Sbjct: 253 SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306

Query: 439 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 496
            +P   +    G  +   ++       W + ++ DS    + +L P   Y ++VL     
Sbjct: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366

Query: 497 SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 547
             G GP    +   T+   P   P N +        + L W P           +    Y
Sbjct: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426

Query: 548 ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607
           + V+   ++  E+   I+  + Y L+GL+P      RL   +P+G   S  E+  +T + 
Sbjct: 427 QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE-ELVVQTEED 483

Query: 608 KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGED------DKPHE 661
            P A P +     P    I + W+PP   + NG+IT Y I Y AV   D       +  +
Sbjct: 484 VPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLDPSADLSSQRGK 541

Query: 662 ILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 714
           +  + ++ T +L   L   T Y  T+ A T  G GP  ++  I T    PS P
Sbjct: 542 VFKLRNE-THHLFVGLYPGTTYSFTIKASTAKGFGP-PVTTRIATKISAPSMP 592



 Score = 65.5 bits (158), Expect = 5e-10
 Identities = 82/336 (24%), Positives = 127/336 (37%), Gaps = 43/336 (12%)

Query: 681 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK- 739
           ++YR  +   +D G G  + + LI      P  PP   E+ AV +T +   W  P  N  
Sbjct: 263 SKYRCVI--RSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL---WIKPNANSI 314

Query: 740 -QHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKG 798
              G I   +V Y R   G         +  + D+ +  +  L P+  Y + V   T  G
Sbjct: 315 IGDGPIILKEVEY-RTTTGT------WAETHIVDSPNYKLWHLDPDVEYEIRVLL-TRPG 366

Query: 799 DGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHP------PVDTFGPLQGY 847
           +G    P    TT       V G   + I   +     +QW P         ++     Y
Sbjct: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426

Query: 848 RLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEE 907
           +  F ++  E    ++ S    H+T   +    +   RL   N  G  E     +   E+
Sbjct: 427 QYVFNQQQYEAEEVIQTSS---HYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEED 483

Query: 908 VPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLI---- 963
           VP   P      G     + + W+PP   E NG+IT Y + Y+ +   L P   L     
Sbjct: 484 VPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVG-SLDPSADLSSQRG 540

Query: 964 ----VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 995
               +  +T     GL P TTY   ++A T+KG GP
Sbjct: 541 KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGP 576



 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 88/400 (22%), Positives = 152/400 (38%), Gaps = 57/400 (14%)

Query: 579 SLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTS------PSSTSILVSWQ 631
           S+  +R   RS  G G S  AE+  +   + P APP+ ++  +      P++ SI+    
Sbjct: 261 SVSKYRCVIRSDGGSGVSNYAELIVKEPPT-PIAPPELLAVGATYLWIKPNANSII---- 315

Query: 632 PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RITVTA 689
                  +G I    ++Y    G   + H +     D+  Y L  L+   EY  R+ +T 
Sbjct: 316 ------GDGPIILKEVEYRTTTGTWAETHIV-----DSPNYKLWHLDPDVEYEIRVLLTR 364

Query: 690 HTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWR--SPVPNKQHGQIRGY 747
             + G GP    +  RT    P   P+ VE+  + +  + + W        + H      
Sbjct: 365 PGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTV 424

Query: 748 QVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKL 807
           Q  YV  +      Q    + ++  +    + GL+P  +  L +     +G    S+  +
Sbjct: 425 QYQYVFNQ------QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGR-MESEELV 477

Query: 808 VSTTGAVPGKPRL--VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRK-DMEPLTTLEF 864
           V T   VPG   L  +          IQW PP +T G +  Y + +     ++P   L  
Sbjct: 478 VQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSS 537

Query: 865 SE-------KEDHFTATDIHKGASYVFRLSARNKVGFG----EEMVKEISIPE--EVPTG 911
                     E H     ++ G +Y F + A    GFG      +  +IS P   E  T 
Sbjct: 538 QRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTD 597

Query: 912 FPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 951
            P N      T T++ +  +P     R   ++ Y L+ ++
Sbjct: 598 TPLN-----ETDTTITVMLKP--AQSRGAPVSVYQLVVKE 630


>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
            [Homo sapiens]
          Length = 1445

 Score =  459 bits (1182), Expect = e-129
 Identities = 264/678 (38%), Positives = 373/678 (55%), Gaps = 52/678 (7%)

Query: 1265 VLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELRRLNFQT---- 1319
            V++ +  +C+++ I +    R  +  +    P   +E+PS         R+  FQT    
Sbjct: 743  VVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKC-FQTAHFY 801

Query: 1320 ------PGMASHPPIPILELAD------------HIERLKANDNLKFSQEYESID---PG 1358
                  P +  +  IPI+ + D            HI  L +N+   FS+++E +      
Sbjct: 802  VEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTAD 861

Query: 1359 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAY 1416
               T EHSN   NK KNRY N++AYDHSRV L  + G     SDY+NANY+DGY K  AY
Sbjct: 862  MNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAY 921

Query: 1417 IATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL 1476
            IATQG L  TF DFWRMIWEQ +  +VM+T L E+ R KCDQYWP+  +E +G + VTL 
Sbjct: 922  IATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLK 981

Query: 1477 DTVELATYCVRTFALYKN-----------GSSEKREVRQFQFTAWPDHGVPEHPTPFLAF 1525
             T   A Y VR F++              G   +R V Q+ +T WPD GVPE+  P L F
Sbjct: 982  STKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTF 1041

Query: 1526 LRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNY 1585
            +RR      P+ GP++VHCSAGVGRTG +IVID+ML++IK + TV++ G +  +R QRNY
Sbjct: 1042 VRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNY 1101

Query: 1586 MVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASS 1645
            +VQTE+QYIFIHDALLEA+    TEV +  L++Y+  +     G   T +E +FK +   
Sbjct: 1102 LVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVG-GKTRLEKQFKLVTQC 1160

Query: 1646 KAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAY 1705
             A      SA   CNK KNR  +++P E  RV L P+ G++G+DYINAS+I GY +   +
Sbjct: 1161 NAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEF 1220

Query: 1706 IATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA-ERSARYQYFVV-- 1762
            I TQ PL  TT+DFWRM+W+HN+ I+VML   + +  ++   YWP+ E S   + F V  
Sbjct: 1221 IITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTL 1279

Query: 1763 ---DPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVH 1819
               D +   N  Q I+ +F +   +D     VR FQ   WP    P S     + I  + 
Sbjct: 1280 ISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVI- 1336

Query: 1820 KTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQ 1879
              +E   +DGP  VH   G    G+   L+ + +++  E  VD+FQ  KM+   RP +  
Sbjct: 1337 -KEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFT 1395

Query: 1880 TEDQYQFSYRAALEYLGS 1897
              +QYQF Y+A L  + +
Sbjct: 1396 DIEQYQFIYKAMLSLVST 1413



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 26/86 (30%), Positives = 42/86 (48%), Gaps = 7/86 (8%)

Query: 710 VPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVM 769
           V S PP  ++V+ +N T+++VSW  P     H  I  Y + Y   +N + K +   KD  
Sbjct: 345 VCSSPPIHMKVQPLNQTALQVSWSQP-ETIYHPPIMNYMISYSWTKNEDEKEKTFTKD-- 401

Query: 770 LADAQDM--IISGLQPETSYSLTVTA 793
               +D+   IS + P++ Y   V A
Sbjct: 402 --SDKDLKATISHVSPDSLYLFRVQA 425


>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
            precursor [Homo sapiens]
          Length = 1436

 Score =  454 bits (1169), Expect = e-127
 Identities = 313/954 (32%), Positives = 463/954 (48%), Gaps = 101/954 (10%)

Query: 1021 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 1067
            ++  + L WE P+  N  +  ++I Y   +       V G           T  +  NL 
Sbjct: 499  LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558

Query: 1068 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 1122
            P  +Y F +   T +G     L    T  +AP       P+ +G++  +  ITV L P  
Sbjct: 559  PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616

Query: 1123 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 1181
                 I  Y +I+   ++ R + ++      +     L  E +  R  + Y G E+    
Sbjct: 617  GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673

Query: 1182 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 1240
               A        FT+GD++ Y GF N  L+  + Y ++F  A     E+++         
Sbjct: 674  LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727

Query: 1241 VVSMDLDPQPITD--EEEGLIW-VVGPVLAVVFIICIVIAILLYKRK------------- 1284
                   P  ++   EE GLI  +    LAV+ ++   I +++ K K             
Sbjct: 728  ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQ 787

Query: 1285 -----------------------------------RAESDSRKSSIPNNKEIPSHHPTDP 1309
                                                   D R   +     +    P  P
Sbjct: 788  EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRP 847

Query: 1310 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLE 1369
               +   + T  +  HP + + +L  HI ++K  +   F QEYES   G    W+ +  +
Sbjct: 848  CGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKK 901

Query: 1370 VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGD 1429
                 +R   + AYD  RV L  + G P +DY+NANYIDGY + N +IATQG  PE   D
Sbjct: 902  DKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYD 961

Query: 1430 FWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTF 1489
            FWRM+W++  +++VM+TKL E  RVKC +YWP   ++T+G +++ L+ T  LA Y VRTF
Sbjct: 962  FWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTF 1020

Query: 1490 ALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVG 1549
            AL + G S + EVRQF FTAWP+HGVP H T  LAF+RRVK   PPDAGP+V+HCSAG G
Sbjct: 1021 ALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTG 1080

Query: 1550 RTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNT 1609
            RTGC+IV+D ML+  + E  VDIY  V  + ++R  M+QTE+QYIFIHDA+LEA  CG T
Sbjct: 1081 RTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGET 1140

Query: 1610 EVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLV 1667
             +P     A  +++ +I+   N + +  EF+ L S            A LP N+ KNR +
Sbjct: 1141 TIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSM 1200

Query: 1668 NIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE 1725
            +++P +    CL  +   +G  ++YINA+  D Y +  A+I T  PL  TT DFWR++++
Sbjct: 1201 DVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYD 1257

Query: 1726 HNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR 1784
            +  T +VML +L +      C QYWP     +Y    V+ M+       + R F+V +  
Sbjct: 1258 YGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNIS 1317

Query: 1785 DGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGR 1841
              Q     VR FQF  W   +  P S + F+  + +V K + + G DG   VHC  G GR
Sbjct: 1318 RLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGR 1376

Query: 1842 TGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1895
            +G F   + VLE +R   +VD+F   K LR  +P MV+T DQY F Y  ALEYL
Sbjct: 1377 SGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1430



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 85/366 (23%), Positives = 148/366 (40%), Gaps = 46/366 (12%)

Query: 300 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 355
           Y CV+ +  G  +   A++ VK  P P   P +  +  T + +  ++ +     P+    
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321

Query: 356 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 413
           I+++       + E+  V+   Y +  L P ++YE  V+     + G G P  P++++T 
Sbjct: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379

Query: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473
              P  AP+ +    + +  + +QW    EP G        YT+    H      HN   
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435

Query: 474 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 519
            +           TI NL+P +   V+++     G     +    +D  V   +G+  + 
Sbjct: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493

Query: 520 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 568
           L F      E  I L W  P+  +  I  YE+ Y+  E         G  + I+ +   T
Sbjct: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550

Query: 569 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSKPSAPPQDI-SCTSPSSTSI 626
            +    L P + Y F + AR+ +G G A+  EI+  T  S PS    D+ S    S  +I
Sbjct: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEIT--TNISAPSFDYADMPSPLGESENTI 608

Query: 627 LVSWQP 632
            V  +P
Sbjct: 609 TVLLRP 614



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)

Query: 365 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 424
           E  K   GV+  RY++  L PY +   R+V  N  GR    E V  QT E  PS    + 
Sbjct: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493

Query: 425 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 478
                    I ++W+EP+EPNG I  Y + Y    + DP  +V    +    + +     
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553

Query: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 531
             NL P  TY   V A T  G G  ++  ++ T    P         PL    E E+  +
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609

Query: 532 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 567
           +LL     R   I+ Y+++    E    +R+  EPG
Sbjct: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 71/277 (25%), Positives = 107/277 (38%), Gaps = 46/277 (16%)

Query: 466 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 523
           W + +    Q   + +L P   Y + VL  T  GDG           TG PG PL  +  
Sbjct: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379

Query: 524 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 561
            AEP                + L W P      R  T     L Y       H +  R  
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438

Query: 562 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 620
           +  E G S Y ++ L P    + RL   +P+G      E++ +T +  PS    +    +
Sbjct: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGK-EVTFQTDEDVPSGIAAESLTFT 497

Query: 621 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDK-----PHEILGIPSDTTKYLLE 675
           P    I + W+ P  ++ NG+IT+Y I Y +++  D       P   +    + T ++  
Sbjct: 498 PLEDMIFLKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFS 555

Query: 676 QLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPS 712
            L   T Y  +V A T  G G  +L+  I TN   PS
Sbjct: 556 NLHPGTTYLFSVRARTGKGFGQAALTE-ITTNISAPS 591



 Score = 58.2 bits (139), Expect = 8e-08
 Identities = 54/256 (21%), Positives = 104/256 (40%), Gaps = 18/256 (7%)

Query: 569 SYRLQGLKPNSLYYFRLAARSPQ--GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSI 626
           +Y+L  L P++ Y   +    P   G G     + +RT  ++P   P+ ++     +  +
Sbjct: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400

Query: 627 LVSWQPPP--VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYR 684
            + W+P    V + +         YT     +    E +      ++Y ++ L  +    
Sbjct: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460

Query: 685 ITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVK----VSWRSPVPNKQ 740
           + +      G   E   V  +T+EDVPSG    +  E++  T ++    + W  P   + 
Sbjct: 461 VRLVLTNPEGR-KEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEP--QEP 513

Query: 741 HGQIRGYQVHYVRMENGEPKGQ---PMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTK 797
           +G I  Y++ Y  +E+ +P      P      L +    + S L P T+Y  +V A T K
Sbjct: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGK 573

Query: 798 GDGARSKPKLVSTTGA 813
           G G  +  ++ +   A
Sbjct: 574 GFGQAALTEITTNISA 589



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 59/233 (25%), Positives = 86/233 (36%), Gaps = 22/233 (9%)

Query: 781 LQPETSYSLTVTAYTTKGDGA--RSKPKLVSTTGAVP---GKPRLVINHTQMNTALIQWH 835
           L P+T Y ++V   T  GDG   R  P L+S T           L     Q     +QW 
Sbjct: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405

Query: 836 P------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKE-DHFTATDIHKGASYVFRLSA 888
           P         T+     Y    G    + +     +E+    +T  ++    +   RL  
Sbjct: 406 PLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVL 465

Query: 889 RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLL 948
            N  G  E         E+VP+G      +       + L W+ P   E NG+IT+Y + 
Sbjct: 466 TNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEP--QEPNGLITQYEIS 523

Query: 949 YRDI-------NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG 994
           Y+ I       N+P        +  +T    + L P TTY   VRA T KG G
Sbjct: 524 YQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 68/343 (19%), Positives = 126/343 (36%), Gaps = 28/343 (8%)

Query: 583 FRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 641
           +R  +++P+G G S  AE+  +   + P APPQ +       T +++      +   +G 
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPT-PIAPPQLLRA---GPTYLIIQLNTNSIIG-DGP 316

Query: 642 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPES 699
           I    I+Y    G   + H +         Y L  L+  TEY I+V  T   D G G   
Sbjct: 317 IVRKEIEYRMARGPWAEVHAV-----SLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPG 371

Query: 700 LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPN--KQHGQIRGYQVHYVRMENG 757
             ++ RT    P   P+ +    + +  + + W     N  + H        HY     G
Sbjct: 372 PPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTL---G 428

Query: 758 EPKGQPMLKDVMLADAQDMI-ISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 816
               Q + + V          I  L P  +  + +     +G     +    +      G
Sbjct: 429 SSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSG 488

Query: 817 KPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDME--------PLTTLEFSEK 867
                +  T +   + ++W  P +  G +  Y + +   +          P  T+     
Sbjct: 489 IAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRN 548

Query: 868 EDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 910
           E +   +++H G +Y+F + AR   GFG+  + EI+     P+
Sbjct: 549 ETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591


>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
            precursor [Homo sapiens]
          Length = 1446

 Score =  449 bits (1156), Expect = e-126
 Identities = 249/615 (40%), Positives = 351/615 (57%), Gaps = 19/615 (3%)

Query: 1289 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 1348
            D R   +     +    P  P   +   + T  +  HP + + +L  HI ++K  +   F
Sbjct: 837  DQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGF 894

Query: 1349 SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID 1408
             QEYES   G    W+ +  +     +R   + AYD  RV L  + G P +DY+NANYID
Sbjct: 895  KQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYID 950

Query: 1409 GYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH 1468
            GY + N +IATQG  PE   DFWRM+W++  +++VM+TKL E  RVKC +YWP   ++T+
Sbjct: 951  GYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTY 1009

Query: 1469 GLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRR 1528
            G +++ L+ T  LA Y VRTFAL + G S + EVRQF FTAWP+HGVP H T  LAF+RR
Sbjct: 1010 GDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRR 1069

Query: 1529 VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ 1588
            VK   PPDAGP+V+HCSAG GRTGC+IV+D ML+  + E  VDIY  V  + ++R  M+Q
Sbjct: 1070 VKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQ 1129

Query: 1589 TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SK 1646
            TE+QYIFIHDA+LEA  CG T +P     A  +++ +I+   N + +  EF+ L S    
Sbjct: 1130 TEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPP 1189

Query: 1647 AHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKA 1704
                    A LP N+ KNR ++++P +    CL  +   +G  ++YINA+  D Y +  A
Sbjct: 1190 LDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAA 1246

Query: 1705 YIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVD 1763
            +I T  PL  TT DFWR+++++  T +VML +L +      C QYWP     +Y    V+
Sbjct: 1247 FIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVE 1306

Query: 1764 PMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHK 1820
             M+       + R F+V +    Q     VR FQF  W   +  P S + F+  + +V K
Sbjct: 1307 FMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDK 1366

Query: 1821 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1880
             + + G DG   VHC  G GR+G F   + VLE +R   +VD+F   K LR  +P MV+T
Sbjct: 1367 WQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVET 1425

Query: 1881 EDQYQFSYRAALEYL 1895
             DQY F Y  ALEYL
Sbjct: 1426 MDQYHFCYDVALEYL 1440



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 85/366 (23%), Positives = 148/366 (40%), Gaps = 46/366 (12%)

Query: 300 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 355
           Y CV+ +  G  +   A++ VK  P P   P +  +  T + +  ++ +     P+    
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321

Query: 356 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 413
           I+++       + E+  V+   Y +  L P ++YE  V+     + G G P  P++++T 
Sbjct: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379

Query: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473
              P  AP+ +    + +  + +QW    EP G        YT+    H      HN   
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435

Query: 474 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 519
            +           TI NL+P +   V+++     G     +    +D  V   +G+  + 
Sbjct: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493

Query: 520 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 568
           L F      E  I L W  P+  +  I  YE+ Y+  E         G  + I+ +   T
Sbjct: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550

Query: 569 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSKPSAPPQDI-SCTSPSSTSI 626
            +    L P + Y F + AR+ +G G A+  EI+  T  S PS    D+ S    S  +I
Sbjct: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEIT--TNISAPSFDYADMPSPLGESENTI 608

Query: 627 LVSWQP 632
            V  +P
Sbjct: 609 TVLLRP 614



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)

Query: 365 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 424
           E  K   GV+  RY++  L PY +   R+V  N  GR    E V  QT E  PS    + 
Sbjct: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493

Query: 425 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 478
                    I ++W+EP+EPNG I  Y + Y    + DP  +V    +    + +     
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553

Query: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 531
             NL P  TY   V A T  G G  ++  ++ T    P         PL    E E+  +
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609

Query: 532 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 567
           +LL     R   I+ Y+++    E    +R+  EPG
Sbjct: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 71/277 (25%), Positives = 107/277 (38%), Gaps = 46/277 (16%)

Query: 466 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 523
           W + +    Q   + +L P   Y + VL  T  GDG           TG PG PL  +  
Sbjct: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379

Query: 524 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 561
            AEP                + L W P      R  T     L Y       H +  R  
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438

Query: 562 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 620
           +  E G S Y ++ L P    + RL   +P+G      E++ +T +  PS    +    +
Sbjct: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGK-EVTFQTDEDVPSGIAAESLTFT 497

Query: 621 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDK-----PHEILGIPSDTTKYLLE 675
           P    I + W+ P  ++ NG+IT+Y I Y +++  D       P   +    + T ++  
Sbjct: 498 PLEDMIFLKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFS 555

Query: 676 QLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPS 712
            L   T Y  +V A T  G G  +L+  I TN   PS
Sbjct: 556 NLHPGTTYLFSVRARTGKGFGQAALTE-ITTNISAPS 591



 Score = 58.2 bits (139), Expect = 8e-08
 Identities = 54/256 (21%), Positives = 104/256 (40%), Gaps = 18/256 (7%)

Query: 569 SYRLQGLKPNSLYYFRLAARSPQ--GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSI 626
           +Y+L  L P++ Y   +    P   G G     + +RT  ++P   P+ ++     +  +
Sbjct: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400

Query: 627 LVSWQPPP--VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYR 684
            + W+P    V + +         YT     +    E +      ++Y ++ L  +    
Sbjct: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460

Query: 685 ITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVK----VSWRSPVPNKQ 740
           + +      G   E   V  +T+EDVPSG    +  E++  T ++    + W  P   + 
Sbjct: 461 VRLVLTNPEGR-KEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEP--QEP 513

Query: 741 HGQIRGYQVHYVRMENGEPKGQ---PMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTK 797
           +G I  Y++ Y  +E+ +P      P      L +    + S L P T+Y  +V A T K
Sbjct: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGK 573

Query: 798 GDGARSKPKLVSTTGA 813
           G G  +  ++ +   A
Sbjct: 574 GFGQAALTEITTNISA 589



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 59/233 (25%), Positives = 86/233 (36%), Gaps = 22/233 (9%)

Query: 781 LQPETSYSLTVTAYTTKGDGA--RSKPKLVSTTGAVP---GKPRLVINHTQMNTALIQWH 835
           L P+T Y ++V   T  GDG   R  P L+S T           L     Q     +QW 
Sbjct: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405

Query: 836 P------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKE-DHFTATDIHKGASYVFRLSA 888
           P         T+     Y    G    + +     +E+    +T  ++    +   RL  
Sbjct: 406 PLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVL 465

Query: 889 RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLL 948
            N  G  E         E+VP+G      +       + L W+ P   E NG+IT+Y + 
Sbjct: 466 TNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEP--QEPNGLITQYEIS 523

Query: 949 YRDI-------NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG 994
           Y+ I       N+P        +  +T    + L P TTY   VRA T KG G
Sbjct: 524 YQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 68/343 (19%), Positives = 126/343 (36%), Gaps = 28/343 (8%)

Query: 583 FRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 641
           +R  +++P+G G S  AE+  +   + P APPQ +       T +++      +   +G 
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPT-PIAPPQLLRA---GPTYLIIQLNTNSIIG-DGP 316

Query: 642 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPES 699
           I    I+Y    G   + H +         Y L  L+  TEY I+V  T   D G G   
Sbjct: 317 IVRKEIEYRMARGPWAEVHAV-----SLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPG 371

Query: 700 LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPN--KQHGQIRGYQVHYVRMENG 757
             ++ RT    P   P+ +    + +  + + W     N  + H        HY     G
Sbjct: 372 PPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTL---G 428

Query: 758 EPKGQPMLKDVMLADAQDMI-ISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 816
               Q + + V          I  L P  +  + +     +G     +    +      G
Sbjct: 429 SSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSG 488

Query: 817 KPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDME--------PLTTLEFSEK 867
                +  T +   + ++W  P +  G +  Y + +   +          P  T+     
Sbjct: 489 IAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRN 548

Query: 868 EDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 910
           E +   +++H G +Y+F + AR   GFG+  + EI+     P+
Sbjct: 549 ETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 63/285 (22%), Positives = 111/285 (38%), Gaps = 34/285 (11%)

Query: 1021 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 1067
            ++  + L WE P+  N  +  ++I Y   +       V G           T  +  NL 
Sbjct: 499  LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558

Query: 1068 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 1122
            P  +Y F +   T +G     L    T  +AP       P+ +G++  +  ITV L P  
Sbjct: 559  PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616

Query: 1123 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 1181
                 I  Y +I+   ++ R + ++      +     L  E +  R  + Y G E+    
Sbjct: 617  GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673

Query: 1182 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 1240
               A        FT+GD++ Y GF N  L+  + Y ++F  A     E+++         
Sbjct: 674  LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727

Query: 1241 VVSMDLDPQPIT--DEEEGLI-WVVGPVLAVVFIICIVIAILLYK 1282
                   P  ++   EE GLI  +    LAV+ ++   I +++ K
Sbjct: 728  ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRK 772


>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
            precursor [Homo sapiens]
          Length = 1442

 Score =  448 bits (1152), Expect = e-125
 Identities = 313/960 (32%), Positives = 463/960 (48%), Gaps = 107/960 (11%)

Query: 1021 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 1067
            ++  + L WE P+  N  +  ++I Y   +       V G           T  +  NL 
Sbjct: 499  LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558

Query: 1068 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 1122
            P  +Y F +   T +G     L    T  +AP       P+ +G++  +  ITV L P  
Sbjct: 559  PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616

Query: 1123 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 1181
                 I  Y +I+   ++ R + ++      +     L  E +  R  + Y G E+    
Sbjct: 617  GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673

Query: 1182 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 1240
               A        FT+GD++ Y GF N  L+  + Y ++F  A     E+++         
Sbjct: 674  LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727

Query: 1241 VVSMDLDPQPITD--EEEGLIW-VVGPVLAVVFIICIVIAILLYKRK------------- 1284
                   P  ++   EE GLI  +    LAV+ ++   I +++ K K             
Sbjct: 728  ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQ 787

Query: 1285 -----------------------------------RAESDSRKSSIPNNKEIPSHHPTDP 1309
                                                   D R   +     +    P  P
Sbjct: 788  EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRP 847

Query: 1310 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLE 1369
               +   + T  +  HP + + +L  HI ++K  +   F QEYES   G    W+ +  +
Sbjct: 848  CGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKK 901

Query: 1370 VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSL 1423
                 +R   + AYD  RV L  + G P +DY+NANYID      GY + N +IATQG  
Sbjct: 902  DKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPK 961

Query: 1424 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1483
            PE   DFWRM+W++  +++VM+TKL E  RVKC +YWP   ++T+G +++ L+ T  LA 
Sbjct: 962  PEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAE 1020

Query: 1484 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVH 1543
            Y VRTFAL + G S + EVRQF FTAWP+HGVP H T  LAF+RRVK   PPDAGP+V+H
Sbjct: 1021 YVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIH 1080

Query: 1544 CSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEA 1603
            CSAG GRTGC+IV+D ML+  + E  VDIY  V  + ++R  M+QTE+QYIFIHDA+LEA
Sbjct: 1081 CSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA 1140

Query: 1604 VTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNK 1661
              CG T +P     A  +++ +I+   N + +  EF+ L S            A LP N+
Sbjct: 1141 CLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR 1200

Query: 1662 FKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDF 1719
             KNR ++++P +    CL  +   +G  ++YINA+  D Y +  A+I T  PL  TT DF
Sbjct: 1201 DKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDF 1257

Query: 1720 WRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1778
            WR+++++  T +VML +L +      C QYWP     +Y    V+ M+       + R F
Sbjct: 1258 WRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVF 1317

Query: 1779 KVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC 1835
            +V +    Q     VR FQF  W   +  P S + F+  + +V K + + G DG   VHC
Sbjct: 1318 RVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHC 1376

Query: 1836 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1895
              G GR+G F   + VLE +R   +VD+F   K LR  +P MV+T DQY F Y  ALEYL
Sbjct: 1377 LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1436



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 85/366 (23%), Positives = 148/366 (40%), Gaps = 46/366 (12%)

Query: 300 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 355
           Y CV+ +  G  +   A++ VK  P P   P +  +  T + +  ++ +     P+    
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321

Query: 356 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 413
           I+++       + E+  V+   Y +  L P ++YE  V+     + G G P  P++++T 
Sbjct: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379

Query: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473
              P  AP+ +    + +  + +QW    EP G        YT+    H      HN   
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435

Query: 474 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 519
            +           TI NL+P +   V+++     G     +    +D  V   +G+  + 
Sbjct: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493

Query: 520 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 568
           L F      E  I L W  P+  +  I  YE+ Y+  E         G  + I+ +   T
Sbjct: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550

Query: 569 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSKPSAPPQDI-SCTSPSSTSI 626
            +    L P + Y F + AR+ +G G A+  EI+  T  S PS    D+ S    S  +I
Sbjct: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEIT--TNISAPSFDYADMPSPLGESENTI 608

Query: 627 LVSWQP 632
            V  +P
Sbjct: 609 TVLLRP 614



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)

Query: 365 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 424
           E  K   GV+  RY++  L PY +   R+V  N  GR    E V  QT E  PS    + 
Sbjct: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493

Query: 425 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 478
                    I ++W+EP+EPNG I  Y + Y    + DP  +V    +    + +     
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553

Query: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 531
             NL P  TY   V A T  G G  ++  ++ T    P         PL    E E+  +
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609

Query: 532 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 567
           +LL     R   I+ Y+++    E    +R+  EPG
Sbjct: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 71/277 (25%), Positives = 107/277 (38%), Gaps = 46/277 (16%)

Query: 466 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 523
           W + +    Q   + +L P   Y + VL  T  GDG           TG PG PL  +  
Sbjct: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379

Query: 524 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 561
            AEP                + L W P      R  T     L Y       H +  R  
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438

Query: 562 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 620
           +  E G S Y ++ L P    + RL   +P+G      E++ +T +  PS    +    +
Sbjct: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGK-EVTFQTDEDVPSGIAAESLTFT 497

Query: 621 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDK-----PHEILGIPSDTTKYLLE 675
           P    I + W+ P  ++ NG+IT+Y I Y +++  D       P   +    + T ++  
Sbjct: 498 PLEDMIFLKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFS 555

Query: 676 QLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPS 712
            L   T Y  +V A T  G G  +L+  I TN   PS
Sbjct: 556 NLHPGTTYLFSVRARTGKGFGQAALTE-ITTNISAPS 591



 Score = 58.2 bits (139), Expect = 8e-08
 Identities = 54/256 (21%), Positives = 104/256 (40%), Gaps = 18/256 (7%)

Query: 569 SYRLQGLKPNSLYYFRLAARSPQ--GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSI 626
           +Y+L  L P++ Y   +    P   G G     + +RT  ++P   P+ ++     +  +
Sbjct: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400

Query: 627 LVSWQPPP--VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYR 684
            + W+P    V + +         YT     +    E +      ++Y ++ L  +    
Sbjct: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460

Query: 685 ITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVK----VSWRSPVPNKQ 740
           + +      G   E   V  +T+EDVPSG    +  E++  T ++    + W  P   + 
Sbjct: 461 VRLVLTNPEGR-KEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEP--QEP 513

Query: 741 HGQIRGYQVHYVRMENGEPKGQ---PMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTK 797
           +G I  Y++ Y  +E+ +P      P      L +    + S L P T+Y  +V A T K
Sbjct: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGK 573

Query: 798 GDGARSKPKLVSTTGA 813
           G G  +  ++ +   A
Sbjct: 574 GFGQAALTEITTNISA 589



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 59/233 (25%), Positives = 86/233 (36%), Gaps = 22/233 (9%)

Query: 781 LQPETSYSLTVTAYTTKGDGA--RSKPKLVSTTGAVP---GKPRLVINHTQMNTALIQWH 835
           L P+T Y ++V   T  GDG   R  P L+S T           L     Q     +QW 
Sbjct: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405

Query: 836 P------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKE-DHFTATDIHKGASYVFRLSA 888
           P         T+     Y    G    + +     +E+    +T  ++    +   RL  
Sbjct: 406 PLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVL 465

Query: 889 RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLL 948
            N  G  E         E+VP+G      +       + L W+ P   E NG+IT+Y + 
Sbjct: 466 TNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEP--QEPNGLITQYEIS 523

Query: 949 YRDI-------NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG 994
           Y+ I       N+P        +  +T    + L P TTY   VRA T KG G
Sbjct: 524 YQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 68/343 (19%), Positives = 126/343 (36%), Gaps = 28/343 (8%)

Query: 583 FRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 641
           +R  +++P+G G S  AE+  +   + P APPQ +       T +++      +   +G 
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPT-PIAPPQLLRA---GPTYLIIQLNTNSIIG-DGP 316

Query: 642 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPES 699
           I    I+Y    G   + H +         Y L  L+  TEY I+V  T   D G G   
Sbjct: 317 IVRKEIEYRMARGPWAEVHAV-----SLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPG 371

Query: 700 LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPN--KQHGQIRGYQVHYVRMENG 757
             ++ RT    P   P+ +    + +  + + W     N  + H        HY     G
Sbjct: 372 PPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTL---G 428

Query: 758 EPKGQPMLKDVMLADAQDMI-ISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 816
               Q + + V          I  L P  +  + +     +G     +    +      G
Sbjct: 429 SSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSG 488

Query: 817 KPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDME--------PLTTLEFSEK 867
                +  T +   + ++W  P +  G +  Y + +   +          P  T+     
Sbjct: 489 IAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRN 548

Query: 868 EDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 910
           E +   +++H G +Y+F + AR   GFG+  + EI+     P+
Sbjct: 549 ETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591


>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
            precursor [Homo sapiens]
          Length = 2315

 Score =  424 bits (1089), Expect = e-118
 Identities = 245/615 (39%), Positives = 345/615 (56%), Gaps = 43/615 (6%)

Query: 1319 TPGMASHPPIPILELAD------------HIERLKANDNL--------KFSQEYESIDPG 1358
            +P + S PP PI  ++D            H+  L A+           +F QE +S    
Sbjct: 1678 SPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVD 1737

Query: 1359 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAY 1416
               T + SN   NK KNRY N++AYDHSRV L+ +    G  +DY+NANY+DGY +  AY
Sbjct: 1738 LGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAY 1797

Query: 1417 IATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL 1476
            IA QG L  T  DFWRMIWE     +VM+T L E+ R KCDQYWP+ G+E +G   VT  
Sbjct: 1798 IAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQK 1857

Query: 1477 DTVELATYCVRTFAL----YKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFLAFLRR 1528
                LA Y VR F L     K GS + R     V Q+ +T WPD GVPE+  P L F+R+
Sbjct: 1858 SVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRK 1917

Query: 1529 VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ 1588
                     GP+VVHCSAGVGRTG +IV+D+ML++I+HE TV+I+G +  +R+QRNY+VQ
Sbjct: 1918 AAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQ 1977

Query: 1589 TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAH 1648
            TE+QY+FIHD L+EA+    TEV   +++AY+  L  I      T +E +F+ L+ S   
Sbjct: 1978 TEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALL-IPGPAGKTKLEKQFQLLSQSNIQ 2036

Query: 1649 TSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIAT 1708
             S + +A   CN+ KNR  +I+P E +RV +  + G EG+DYINAS+I GY Q   +I T
Sbjct: 2037 QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIIT 2095

Query: 1709 QGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE 1767
            Q PL  T +DFWRM+W+HN+ +VVM+   + M  ++   YWP  +     + F V  MAE
Sbjct: 2096 QHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAE 2154

Query: 1768 -----YNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTK 1822
                  N  + I+++F +   +D     VR FQ   WP    P S     + I  +   +
Sbjct: 2155 EHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVI--KE 2210

Query: 1823 EQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED 1882
            E   +DGP+ VH   G    G F  L+ ++ ++  E  VD++Q  KM+   RP +    +
Sbjct: 2211 EAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIE 2270

Query: 1883 QYQFSYRAALEYLGS 1897
            QYQF Y+  L  + +
Sbjct: 2271 QYQFLYKVILSLVST 2285



 Score =  115 bits (288), Expect = 4e-25
 Identities = 77/264 (29%), Positives = 129/264 (48%), Gaps = 10/264 (3%)

Query: 1359 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIA 1418
            QQ  +  +  + N+ KNR +++I  + SRV +S++ G  G+DY+NA+YI GY + N +I 
Sbjct: 2036 QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFII 2094

Query: 1419 TQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH-GLVQVTLLD 1477
            TQ  L  T  DFWRMIW+  +  VVM+   +  +  +   YWP++    +    +VTL+ 
Sbjct: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKDEPINCESFKVTLMA 2153

Query: 1478 TVELAT-----YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC 1532
                         ++ F L         EVR FQ   WP+   P   T  L  + + +  
Sbjct: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAA 2213

Query: 1533 NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQ 1592
            N    GPM+VH   G    G F  +  ++ +++ E +VD+Y    ++   R  +    +Q
Sbjct: 2214 NRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQ 2271

Query: 1593 YIFIHDALLEAVTCGNTEVPARNL 1616
            Y F++  +L  V+    E P+ +L
Sbjct: 2272 YQFLYKVILSLVSTRQEENPSTSL 2295



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 18/54 (33%), Positives = 32/54 (59%), Gaps = 1/54 (1%)

Query: 610 SAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEIL 663
           S+ P+++     + TS+LV+W+ P V     +I ++++ Y  +DGED   HE L
Sbjct: 312 SSEPENVQADPENYTSLLVTWERPRVVYDT-MIEKFAVLYQQLDGEDQTKHEFL 364



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 7/83 (8%)

Query: 518 QPLNFKAEPESETSILLSWTPPR---SDTIANYELVYK--DGEHGEEQRITIE--PGTSY 570
           +P N +A+PE+ TS+L++W  PR      I  + ++Y+  DGE   +     +       
Sbjct: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGA 373

Query: 571 RLQGLKPNSLYYFRLAARSPQGL 593
            L  L PN  Y  ++ A    GL
Sbjct: 374 ILNNLLPNMSYVLQIVAICTNGL 396



 Score = 33.1 bits (74), Expect = 2.7
 Identities = 56/231 (24%), Positives = 90/231 (38%), Gaps = 30/231 (12%)

Query: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEP-NGQIQGYRVYYTM----DPTQHVNNWMK 468
           E   SS P +VQA   + T++LV W+ P    +  I+ + V Y      D T+H   ++ 
Sbjct: 308 EAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKH--EFLT 365

Query: 469 HNVADSQITTIGNLVPQKTYSVKVLAFTSIG-DGPLSSDIQVITQTGVP---------GQ 518
               D     + NL+P  +Y ++++A  + G  G  S  + V   T  P         G 
Sbjct: 366 DGYQDLG-AILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPELIGT 424

Query: 519 PLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPN 578
               K E E +     +   P  D+  N ++  K+ +        I   T Y   G K N
Sbjct: 425 EEIIKEEEEGKDIEEGAIVNPGRDSATN-QIRKKEPQ--------ISTTTHYNRIGTKYN 475

Query: 579 SLYYFRLAARSPQGLGASTAEISARTMQSKP---SAPPQDISCTSPSSTSI 626
                R   R  +  G      ++    S+P    A  +DIS TS + T +
Sbjct: 476 EAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTEL 526


>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
            precursor [Homo sapiens]
          Length = 1256

 Score =  396 bits (1018), Expect = e-110
 Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)

Query: 1327 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 1385
            PI    L +  +R  A++   F  E++SI     +F  + +    N+ KNRY +++ YD+
Sbjct: 582  PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 641

Query: 1386 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1445
            +RV LS I G  GS+Y+NA+YIDG+++   YIA QG   ET  DFWRMIWEQ++  +VM+
Sbjct: 642  NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 701

Query: 1446 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1502
            T+ EE +R KC +YWPS   GT   G V V +        Y ++   +  K   +  REV
Sbjct: 702  TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 761

Query: 1503 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1562
               QFT+WPDHGVPE P   L   RRV   +   +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 762  THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 821

Query: 1563 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1622
             ++ E  VD+YG+V  +R QR  MVQ E QYI IH AL+E    G TEV    L+ Y+  
Sbjct: 822  GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 881

Query: 1623 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1680
            + + +     + +E EF+RL S ++  ++ I  N   NK KNR  N++PY+  RV L+  
Sbjct: 882  MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 940

Query: 1681 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1723
                                  E S YINASFI  Y + +  IA QGPL ET  DFW+M+
Sbjct: 941  LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1000

Query: 1724 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1783
            ++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR F++  +
Sbjct: 1001 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1059

Query: 1784 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1835
            +   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ +HC
Sbjct: 1060 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1119

Query: 1836 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1888
              G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T +QYQF Y
Sbjct: 1120 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172



 Score =  197 bits (501), Expect = 8e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 1655 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1714
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681

Query: 1715 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1772
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 682  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741

Query: 1773 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1831
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 742  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799

Query: 1832 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1891
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY   ++A 
Sbjct: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859

Query: 1892 LEY 1894
            +EY
Sbjct: 860  VEY 862



 Score =  156 bits (395), Expect = 2e-37
 Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)

Query: 1328 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 1382
            + + EL  ++  +K  D          E++ +   + +  +H  N E NK KNR +NVI 
Sbjct: 870  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 929

Query: 1383 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1423
            YD++RV L         S  +    SD          Y+NA++I  Y K    IA QG L
Sbjct: 930  YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 989

Query: 1424 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1483
             ET GDFW+MI++++   +VM+T+L+   +  C QYW   G +T+G ++V L DT + +T
Sbjct: 990  KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 1048

Query: 1484 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1536
            Y +R F L  +   + R V Q+Q+T W    +P  P   ++ ++ VK   P         
Sbjct: 1049 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 1108

Query: 1537 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1593
               + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V  +R  R  MV T +QY
Sbjct: 1109 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1168

Query: 1594 IFIHDALLEAVTCGNTEVPARN 1615
             F++D +       N +V   N
Sbjct: 1169 QFLYDVIASTYPAQNGQVKKNN 1190



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 22/226 (9%)

Query: 430 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 487
           + TTI ++WK  E            +T D TQ++    +  + + D++   + NL P+  
Sbjct: 267 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 314

Query: 488 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 547
           Y        +      +S I + T  G PG+P       E+    +++W PP+  +  N+
Sbjct: 315 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 372

Query: 548 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEISARTM 605
            L Y   +  E+  + ++     Y LQ LKP + Y   L A     +  + +A +   T 
Sbjct: 373 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT 430

Query: 606 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 651
           +S P +   +++ +  S  S+ V  +PP    +NG    Y ++  A
Sbjct: 431 KSAPPSQVWNMTVSMTSDNSMHVKCRPP--RDRNGPHERYHLEVEA 474



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 47/218 (21%), Positives = 82/218 (37%), Gaps = 37/218 (16%)

Query: 613 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 672
           PQ I C S ++   +++W PP     N   T   IK T  D         L +  +  KY
Sbjct: 345 PQIIFCRSEAAHQGVITWNPPQRSFHN--FTLCYIKETEKD--------CLNLDKNLIKY 394

Query: 673 LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR-TNEDVPSGPPRKVEVEAVNSTSVKVS 731
            L+ L+ +T+Y +++ A+          + +   T +  P      + V   +  S+ V 
Sbjct: 395 DLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVK 454

Query: 732 WRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTV 791
            R   P  ++G    Y +           G  ++++    +  D  +  LQ  T Y  T 
Sbjct: 455 CRP--PRDRNGPHERYHLEV-------EAGNTLVRNESHKNC-DFRVKDLQYSTDY--TF 502

Query: 792 TAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNT 829
            AY   GD               PG+P ++ + T  N+
Sbjct: 503 KAYFHNGD--------------YPGEPFILHHSTSYNS 526



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 10/127 (7%)

Query: 778 ISGLQPETSYSLTVTAYT-TKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQW 834
           +  L+P T Y L++ AY   K     S      TT + P      + ++ T  N+  ++ 
Sbjct: 396 LQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKC 455

Query: 835 HPPVDTFGPLQGYRLKFGRKDMEPLTTL--EFSEKEDHFTATDIHKGASYVFRLSARNKV 892
            PP D  GP + Y L     ++E   TL    S K   F   D+     Y F+    N  
Sbjct: 456 RPPRDRNGPHERYHL-----EVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGD 510

Query: 893 GFGEEMV 899
             GE  +
Sbjct: 511 YPGEPFI 517


>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
            precursor [Homo sapiens]
          Length = 1304

 Score =  396 bits (1018), Expect = e-110
 Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)

Query: 1327 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 1385
            PI    L +  +R  A++   F  E++SI     +F  + +    N+ KNRY +++ YD+
Sbjct: 630  PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 689

Query: 1386 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1445
            +RV LS I G  GS+Y+NA+YIDG+++   YIA QG   ET  DFWRMIWEQ++  +VM+
Sbjct: 690  NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 749

Query: 1446 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1502
            T+ EE +R KC +YWPS   GT   G V V +        Y ++   +  K   +  REV
Sbjct: 750  TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 809

Query: 1503 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1562
               QFT+WPDHGVPE P   L   RRV   +   +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 810  THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 869

Query: 1563 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1622
             ++ E  VD+YG+V  +R QR  MVQ E QYI IH AL+E    G TEV    L+ Y+  
Sbjct: 870  GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 929

Query: 1623 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1680
            + + +     + +E EF+RL S ++  ++ I  N   NK KNR  N++PY+  RV L+  
Sbjct: 930  MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 988

Query: 1681 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1723
                                  E S YINASFI  Y + +  IA QGPL ET  DFW+M+
Sbjct: 989  LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1048

Query: 1724 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1783
            ++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR F++  +
Sbjct: 1049 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1107

Query: 1784 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1835
            +   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ +HC
Sbjct: 1108 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1167

Query: 1836 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1888
              G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T +QYQF Y
Sbjct: 1168 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1220



 Score =  197 bits (501), Expect = 8e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 1655 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1714
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 670  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 729

Query: 1715 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1772
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 730  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 789

Query: 1773 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1831
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 790  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 847

Query: 1832 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1891
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY   ++A 
Sbjct: 848  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907

Query: 1892 LEY 1894
            +EY
Sbjct: 908  VEY 910



 Score =  156 bits (395), Expect = 2e-37
 Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)

Query: 1328 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 1382
            + + EL  ++  +K  D          E++ +   + +  +H  N E NK KNR +NVI 
Sbjct: 918  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 977

Query: 1383 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1423
            YD++RV L         S  +    SD          Y+NA++I  Y K    IA QG L
Sbjct: 978  YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 1037

Query: 1424 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1483
             ET GDFW+MI++++   +VM+T+L+   +  C QYW   G +T+G ++V L DT + +T
Sbjct: 1038 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 1096

Query: 1484 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1536
            Y +R F L  +   + R V Q+Q+T W    +P  P   ++ ++ VK   P         
Sbjct: 1097 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 1156

Query: 1537 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1593
               + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V  +R  R  MV T +QY
Sbjct: 1157 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1216

Query: 1594 IFIHDALLEAVTCGNTEVPARN 1615
             F++D +       N +V   N
Sbjct: 1217 QFLYDVIASTYPAQNGQVKKNN 1238



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 22/226 (9%)

Query: 430 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 487
           + TTI ++WK  E            +T D TQ++    +  + + D++   + NL P+  
Sbjct: 315 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 362

Query: 488 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 547
           Y        +      +S I + T  G PG+P       E+    +++W PP+  +  N+
Sbjct: 363 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 420

Query: 548 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEISARTM 605
            L Y   +  E+  + ++     Y LQ LKP + Y   L A     +  + +A +   T 
Sbjct: 421 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT 478

Query: 606 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 651
           +S P +   +++ +  S  S+ V  +PP    +NG    Y ++  A
Sbjct: 479 KSAPPSQVWNMTVSMTSDNSMHVKCRPP--RDRNGPHERYHLEVEA 522



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 47/218 (21%), Positives = 82/218 (37%), Gaps = 37/218 (16%)

Query: 613 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 672
           PQ I C S ++   +++W PP     N   T   IK T  D         L +  +  KY
Sbjct: 393 PQIIFCRSEAAHQGVITWNPPQRSFHN--FTLCYIKETEKD--------CLNLDKNLIKY 442

Query: 673 LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR-TNEDVPSGPPRKVEVEAVNSTSVKVS 731
            L+ L+ +T+Y +++ A+          + +   T +  P      + V   +  S+ V 
Sbjct: 443 DLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVK 502

Query: 732 WRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTV 791
            R   P  ++G    Y +           G  ++++    +  D  +  LQ  T Y  T 
Sbjct: 503 CRP--PRDRNGPHERYHLEV-------EAGNTLVRNESHKNC-DFRVKDLQYSTDY--TF 550

Query: 792 TAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNT 829
            AY   GD               PG+P ++ + T  N+
Sbjct: 551 KAYFHNGD--------------YPGEPFILHHSTSYNS 574



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 10/127 (7%)

Query: 778 ISGLQPETSYSLTVTAYT-TKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQW 834
           +  L+P T Y L++ AY   K     S      TT + P      + ++ T  N+  ++ 
Sbjct: 444 LQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKC 503

Query: 835 HPPVDTFGPLQGYRLKFGRKDMEPLTTL--EFSEKEDHFTATDIHKGASYVFRLSARNKV 892
            PP D  GP + Y L     ++E   TL    S K   F   D+     Y F+    N  
Sbjct: 504 RPPRDRNGPHERYHL-----EVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGD 558

Query: 893 GFGEEMV 899
             GE  +
Sbjct: 559 YPGEPFI 565


>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
            precursor [Homo sapiens]
          Length = 1143

 Score =  396 bits (1018), Expect = e-110
 Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)

Query: 1327 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 1385
            PI    L +  +R  A++   F  E++SI     +F  + +    N+ KNRY +++ YD+
Sbjct: 469  PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 528

Query: 1386 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1445
            +RV LS I G  GS+Y+NA+YIDG+++   YIA QG   ET  DFWRMIWEQ++  +VM+
Sbjct: 529  NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 588

Query: 1446 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1502
            T+ EE +R KC +YWPS   GT   G V V +        Y ++   +  K   +  REV
Sbjct: 589  TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 648

Query: 1503 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1562
               QFT+WPDHGVPE P   L   RRV   +   +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 649  THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 708

Query: 1563 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1622
             ++ E  VD+YG+V  +R QR  MVQ E QYI IH AL+E    G TEV    L+ Y+  
Sbjct: 709  GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 768

Query: 1623 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1680
            + + +     + +E EF+RL S ++  ++ I  N   NK KNR  N++PY+  RV L+  
Sbjct: 769  MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 827

Query: 1681 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1723
                                  E S YINASFI  Y + +  IA QGPL ET  DFW+M+
Sbjct: 828  LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 887

Query: 1724 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1783
            ++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR F++  +
Sbjct: 888  FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 946

Query: 1784 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1835
            +   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ +HC
Sbjct: 947  KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1006

Query: 1836 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1888
              G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T +QYQF Y
Sbjct: 1007 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059



 Score =  197 bits (501), Expect = 8e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 1655 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1714
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 509  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568

Query: 1715 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1772
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 569  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628

Query: 1773 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1831
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 629  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686

Query: 1832 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1891
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY   ++A 
Sbjct: 687  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746

Query: 1892 LEY 1894
            +EY
Sbjct: 747  VEY 749



 Score =  156 bits (395), Expect = 2e-37
 Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)

Query: 1328 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 1382
            + + EL  ++  +K  D          E++ +   + +  +H  N E NK KNR +NVI 
Sbjct: 757  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 816

Query: 1383 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1423
            YD++RV L         S  +    SD          Y+NA++I  Y K    IA QG L
Sbjct: 817  YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 876

Query: 1424 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1483
             ET GDFW+MI++++   +VM+T+L+   +  C QYW   G +T+G ++V L DT + +T
Sbjct: 877  KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 935

Query: 1484 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1536
            Y +R F L  +   + R V Q+Q+T W    +P  P   ++ ++ VK   P         
Sbjct: 936  YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 995

Query: 1537 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1593
               + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V  +R  R  MV T +QY
Sbjct: 996  HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1055

Query: 1594 IFIHDALLEAVTCGNTEVPARN 1615
             F++D +       N +V   N
Sbjct: 1056 QFLYDVIASTYPAQNGQVKKNN 1077



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 22/226 (9%)

Query: 430 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 487
           + TTI ++WK  E            +T D TQ++    +  + + D++   + NL P+  
Sbjct: 154 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 201

Query: 488 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 547
           Y        +      +S I + T  G PG+P       E+    +++W PP+  +  N+
Sbjct: 202 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 259

Query: 548 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEISARTM 605
            L Y   +  E+  + ++     Y LQ LKP + Y   L A     +  + +A +   T 
Sbjct: 260 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT 317

Query: 606 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 651
           +S P +   +++ +  S  S+ V  +PP    +NG    Y ++  A
Sbjct: 318 KSAPPSQVWNMTVSMTSDNSMHVKCRPP--RDRNGPHERYHLEVEA 361



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 47/218 (21%), Positives = 82/218 (37%), Gaps = 37/218 (16%)

Query: 613 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 672
           PQ I C S ++   +++W PP     N   T   IK T  D         L +  +  KY
Sbjct: 232 PQIIFCRSEAAHQGVITWNPPQRSFHN--FTLCYIKETEKD--------CLNLDKNLIKY 281

Query: 673 LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR-TNEDVPSGPPRKVEVEAVNSTSVKVS 731
            L+ L+ +T+Y +++ A+          + +   T +  P      + V   +  S+ V 
Sbjct: 282 DLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVK 341

Query: 732 WRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTV 791
            R   P  ++G    Y +           G  ++++    +  D  +  LQ  T Y  T 
Sbjct: 342 CRP--PRDRNGPHERYHLEV-------EAGNTLVRNESHKNC-DFRVKDLQYSTDY--TF 389

Query: 792 TAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNT 829
            AY   GD               PG+P ++ + T  N+
Sbjct: 390 KAYFHNGD--------------YPGEPFILHHSTSYNS 413



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 10/127 (7%)

Query: 778 ISGLQPETSYSLTVTAYT-TKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQW 834
           +  L+P T Y L++ AY   K     S      TT + P      + ++ T  N+  ++ 
Sbjct: 283 LQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKC 342

Query: 835 HPPVDTFGPLQGYRLKFGRKDMEPLTTL--EFSEKEDHFTATDIHKGASYVFRLSARNKV 892
            PP D  GP + Y L     ++E   TL    S K   F   D+     Y F+    N  
Sbjct: 343 RPPRDRNGPHERYHL-----EVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGD 397

Query: 893 GFGEEMV 899
             GE  +
Sbjct: 398 YPGEPFI 404


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.133    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,166,049
Number of Sequences: 37866
Number of extensions: 3806541
Number of successful extensions: 22422
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 310
Number of HSP's successfully gapped in prelim test: 232
Number of HSP's that attempted gapping in prelim test: 9471
Number of HSP's gapped (non-prelim): 4067
length of query: 1903
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1786
effective length of database: 13,817,196
effective search space: 24677512056
effective search space used: 24677512056
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.