Search of human proteins with 18860890

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|18860890 protein tyrosine phosphatase, receptor type, D
isoform 2 precursor [Homo sapiens]
         (1899 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...  3847   0.0  
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...  3834   0.0  
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...  3804   0.0  
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...  2810   0.0  
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...  2806   0.0  
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...  2716   0.0  
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...  2703   0.0  
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo...  1894   0.0  
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...  1888   0.0  
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...  1541   0.0  
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...  1541   0.0  
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor...   602   e-171
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo...   601   e-171
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo...   601   e-171
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor...   556   e-158
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo...   550   e-156
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo...   509   e-144
gi|208431815 protein tyrosine phosphatase, receptor type, K isof...   503   e-142
gi|157419150 protein tyrosine phosphatase, receptor type, M isof...   498   e-140
gi|157419152 protein tyrosine phosphatase, receptor type, M isof...   498   e-140
gi|148539860 protein tyrosine phosphatase, receptor type, T isof...   495   e-139
gi|148539858 protein tyrosine phosphatase, receptor type, T isof...   490   e-138
gi|194097398 protein tyrosine phosphatase, receptor type, G prec...   459   e-129
gi|110735404 protein tyrosine phosphatase, receptor type, U isof...   454   e-127
gi|110735402 protein tyrosine phosphatase, receptor type, U isof...   449   e-126
gi|110735406 protein tyrosine phosphatase, receptor type, U isof...   448   e-125
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p...   424   e-118
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo...   396   e-110
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo...   396   e-110
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo...   396   e-110

>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score = 3847 bits (9977), Expect = 0.0
 Identities = 1899/1899 (100%), Positives = 1899/1899 (100%)

Query: 1    MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
            MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1    MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60

Query: 61   GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
            GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61   GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120

Query: 121  IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
            IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121  IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180

Query: 181  GALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSV 240
            GALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSV
Sbjct: 181  GALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSV 240

Query: 241  NITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEA 300
            NITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEA
Sbjct: 241  NITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEA 300

Query: 301  IAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGV 360
            IAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGV
Sbjct: 301  IAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGV 360

Query: 361  ATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTT 420
            ATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTT
Sbjct: 361  ATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTT 420

Query: 421  ILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVL 480
            ILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVL
Sbjct: 421  ILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVL 480

Query: 481  AFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKD 540
            AFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKD
Sbjct: 481  AFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKD 540

Query: 541  GEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPP 600
            GEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPP
Sbjct: 541  GEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPP 600

Query: 601  QDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYL 660
            QDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYL
Sbjct: 601  QDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYL 660

Query: 661  LEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWR 720
            LEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWR
Sbjct: 661  LEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWR 720

Query: 721  SPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPE 780
            SPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPE
Sbjct: 721  SPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPE 780

Query: 781  TSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPL 840
            TSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPL
Sbjct: 781  TSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPL 840

Query: 841  QGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI 900
            QGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI
Sbjct: 841  QGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI 900

Query: 901  PEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIV 960
            PEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIV
Sbjct: 901  PEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIV 960

Query: 961  PADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTS 1020
            PADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTS
Sbjct: 961  PADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTS 1020

Query: 1021 VLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAG 1080
            VLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAG
Sbjct: 1021 VLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAG 1080

Query: 1081 GLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGK 1140
            GLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGK
Sbjct: 1081 GLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGK 1140

Query: 1141 FIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGG 1200
            FIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGG
Sbjct: 1141 FIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGG 1200

Query: 1201 FTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGP 1260
            FTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGP
Sbjct: 1201 FTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGP 1260

Query: 1261 VLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMAS 1320
            VLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMAS
Sbjct: 1261 VLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMAS 1320

Query: 1321 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1380
            HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD
Sbjct: 1321 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1380

Query: 1381 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1440
            HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM
Sbjct: 1381 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1440

Query: 1441 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1500
            MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ
Sbjct: 1441 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1500

Query: 1501 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1560
            FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI
Sbjct: 1501 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1560

Query: 1561 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1620
            KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT
Sbjct: 1561 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1620

Query: 1621 QIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRG 1680
            QIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRG
Sbjct: 1621 QIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRG 1680

Query: 1681 VEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREK 1740
            VEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREK
Sbjct: 1681 VEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREK 1740

Query: 1741 CHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGV 1800
            CHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGV
Sbjct: 1741 CHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGV 1800

Query: 1801 PKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF 1860
            PKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF
Sbjct: 1801 PKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF 1860

Query: 1861 QTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1899
            QTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT
Sbjct: 1861 QTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1899


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score = 3834 bits (9942), Expect = 0.0
 Identities = 1899/1912 (99%), Positives = 1899/1912 (99%), Gaps = 13/1912 (0%)

Query: 1    MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
            MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1    MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60

Query: 61   GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
            GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61   GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120

Query: 121  IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
            IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121  IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180

Query: 181  ---------GALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVPPRFSI 227
                     GALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVR    VRRVPPRFSI
Sbjct: 181  ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240

Query: 228  PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 287
            PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 241  PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300

Query: 288  TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 347
            TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 301  TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360

Query: 348  KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 407
            KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 361  KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420

Query: 408  PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 467
            PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 421  PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480

Query: 468  NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 527
            NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 481  NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540

Query: 528  SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 587
            SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 541  SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600

Query: 588  SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 647
            SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH
Sbjct: 601  SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 660

Query: 648  EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV 707
            EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV
Sbjct: 661  EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV 720

Query: 708  EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDT 767
            EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDT
Sbjct: 721  EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDT 780

Query: 768  TEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL 827
            TEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL
Sbjct: 781  TEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL 840

Query: 828  IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK 887
            IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK
Sbjct: 841  IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK 900

Query: 888  VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 947
            VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD
Sbjct: 901  VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 960

Query: 948  INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF 1007
            INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF
Sbjct: 961  INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF 1020

Query: 1008 AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS 1067
            AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS
Sbjct: 1021 AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS 1080

Query: 1068 YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY 1127
            YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY
Sbjct: 1081 YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY 1140

Query: 1128 YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP 1187
            YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP
Sbjct: 1141 YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP 1200

Query: 1188 TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI 1247
            TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI
Sbjct: 1201 TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI 1260

Query: 1248 TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE 1307
            TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE
Sbjct: 1261 TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE 1320

Query: 1308 LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN 1367
            LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN
Sbjct: 1321 LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN 1380

Query: 1368 KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW 1427
            KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW
Sbjct: 1381 KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW 1440

Query: 1428 RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL 1487
            RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL
Sbjct: 1441 RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL 1500

Query: 1488 YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT 1547
            YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT
Sbjct: 1501 YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT 1560

Query: 1548 GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV 1607
            GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV
Sbjct: 1561 GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV 1620

Query: 1608 PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP 1667
            PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP
Sbjct: 1621 PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP 1680

Query: 1668 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV 1727
            YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV
Sbjct: 1681 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV 1740

Query: 1728 VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV 1787
            VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV
Sbjct: 1741 VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV 1800

Query: 1788 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1847
            RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV
Sbjct: 1801 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1860

Query: 1848 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1899
            LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT
Sbjct: 1861 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1912


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
            precursor [Homo sapiens]
          Length = 1903

 Score = 3804 bits (9865), Expect = 0.0
 Identities = 1890/1912 (98%), Positives = 1890/1912 (98%), Gaps = 22/1912 (1%)

Query: 1    MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
            MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1    MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60

Query: 61   GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
            GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61   GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120

Query: 121  IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
            IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121  IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180

Query: 181  ---------GALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVPPRFSI 227
                     GALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVR    VRRVPPRFSI
Sbjct: 181  ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240

Query: 228  PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 287
            PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 241  PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300

Query: 288  TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 347
            TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 301  TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360

Query: 348  KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 407
            KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 361  KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420

Query: 408  PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 467
            PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 421  PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480

Query: 468  NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 527
            NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 481  NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540

Query: 528  SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 587
            SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 541  SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600

Query: 588  SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 647
            SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH
Sbjct: 601  SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 660

Query: 648  EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV 707
            EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV
Sbjct: 661  EILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV 720

Query: 708  EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDT 767
            EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ      
Sbjct: 721  EAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ------ 774

Query: 768  TEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL 827
               DMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL
Sbjct: 775  ---DMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL 831

Query: 828  IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK 887
            IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK
Sbjct: 832  IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK 891

Query: 888  VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 947
            VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD
Sbjct: 892  VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 951

Query: 948  INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF 1007
            INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF
Sbjct: 952  INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVF 1011

Query: 1008 AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS 1067
            AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS
Sbjct: 1012 AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS 1071

Query: 1068 YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY 1127
            YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY
Sbjct: 1072 YSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGY 1131

Query: 1128 YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP 1187
            YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP
Sbjct: 1132 YIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLP 1191

Query: 1188 TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI 1247
            TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI
Sbjct: 1192 TEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPI 1251

Query: 1248 TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE 1307
            TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE
Sbjct: 1252 TDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVE 1311

Query: 1308 LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN 1367
            LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN
Sbjct: 1312 LRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVN 1371

Query: 1368 KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW 1427
            KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW
Sbjct: 1372 KPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW 1431

Query: 1428 RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL 1487
            RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL
Sbjct: 1432 RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFAL 1491

Query: 1488 YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT 1547
            YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT
Sbjct: 1492 YKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT 1551

Query: 1548 GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV 1607
            GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV
Sbjct: 1552 GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV 1611

Query: 1608 PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP 1667
            PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP
Sbjct: 1612 PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP 1671

Query: 1668 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV 1727
            YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV
Sbjct: 1672 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV 1731

Query: 1728 VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV 1787
            VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV
Sbjct: 1732 VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTV 1791

Query: 1788 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1847
            RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV
Sbjct: 1792 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1851

Query: 1848 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1899
            LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT
Sbjct: 1852 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1903


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score = 2810 bits (7284), Expect = 0.0
 Identities = 1373/1895 (72%), Positives = 1593/1895 (84%), Gaps = 28/1895 (1%)

Query: 20   AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
            AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29   AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88

Query: 80   SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
            +VLRIQPLRTPRDE +YECVA N+VGEI+V  +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89   AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148

Query: 140  TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECV 199
            TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRSGALQIE SEE+DQGKYECV
Sbjct: 149  TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECV 208

Query: 200  ATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLG 259
            ATNSAG RYS+PANLYVRVRRV PRFSI P +HEIMPGG+VNITCVAVGSPMPYVKWM G
Sbjct: 209  ATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQG 268

Query: 260  AEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVT 319
            AEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITVK+LPK PGTP+VT
Sbjct: 269  AEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVT 328

Query: 320  ESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFR 379
            E+TATSIT+TWDSGNP+PVSYY+I++K K+ +  Y+  + + TTRYS+ GLSP S+YE  
Sbjct: 329  ENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIW 388

Query: 380  VVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYR 439
            V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+EP EPNG I+GYR
Sbjct: 389  VSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYR 448

Query: 440  VYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQ 499
            VYYTM+P   V NW KHNV DS +TT+G+L+  +TY+V+VLAFTS+GDGPLS  IQV TQ
Sbjct: 449  VYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQ 508

Query: 500  TGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRL 559
             GVPGQP+N +AE  SETSI LSW+PPR ++I  YEL++++G+HG E   T +P TSY +
Sbjct: 509  QGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVV 568

Query: 560  QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQP 619
            + LKPN+ Y FRLAARSPQGLGA T  +  RT+QSKPSAPPQD+ C S  ST+ILVSW+P
Sbjct: 569  EDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRP 628

Query: 620  PPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTD 679
            PP E  NG +  YS++Y  +  ED +P E+ GIP  TT+ LLE LEKWT+YRIT  AHT+
Sbjct: 629  PPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTE 688

Query: 680  VGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYV 739
            VGPGPES  V++RT+EDVPS PPRKVE EA+N+T+++V WRSP P +QHGQIRGYQVHYV
Sbjct: 689  VGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYV 748

Query: 740  RMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARS 799
            RME  E +G P +KDVMLADAQ         +M+I+ LQPET+YS+TV AYT KGDGARS
Sbjct: 749  RMEGAEARGPPRIKDVMLADAQ---------EMVITNLQPETAYSITVAAYTMKGDGARS 799

Query: 800  KPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTF-GPLQGYRLKFGRKDMEPLTTL 858
            KPK+V T GAV G+P L +  T   + L +W PP  T    + GYRL+FGR+D  PL TL
Sbjct: 800  KPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATL 859

Query: 859  EFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTT 918
            EF   ED +TA+ +HKGA+YVFRL+AR++ G GEE  + +SIPE+ P G PQ L + G  
Sbjct: 860  EFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNA 919

Query: 919  ST-SVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPA------DTTMTLTGL 971
            S  +V L W PPV AERNG I KYT+  R+    L P  +  +PA      +  +TL GL
Sbjct: 920  SAGTVLLRWLPPVPAERNGAIVKYTVAVREAGA-LGPARETELPAAAEPGAENALTLQGL 978

Query: 972  KPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENY 1031
            KPDT YD++VRAHT +GPGP+SP V++RT   DQV  KNF VK +MKTSVLLSWE P+NY
Sbjct: 979  KPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNY 1038

Query: 1032 NSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTA 1091
            NS  P+KI Y+   +  +VDGR T+KLI +LKP   Y+FVLTNRG+S GGLQ  VTA TA
Sbjct: 1039 NSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTA 1096

Query: 1092 PDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDE 1150
             ++L  KP+   K + DG I V LP+  +   ++ Y+I++VPL+KSRG +F+ P  SP++
Sbjct: 1097 FNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPED 1156

Query: 1151 MELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQS 1208
            M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP  F  GD K YGGF N+ L+ 
Sbjct: 1157 MDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEP 1216

Query: 1209 GQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFII 1268
            G  YV FVLAV++ +E   +A SP+SDP    + DPQPI D EEGLIWV+GPVLAVVFII
Sbjct: 1217 GHRYVLFVLAVLQKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFII 1275

Query: 1269 CIVIAILLYKRK----RAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPI 1324
            CIVIAILLYK K    R +S+ R   + NN ++  HHP DPVE+RR+NFQTPGM SHPPI
Sbjct: 1276 CIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPI 1335

Query: 1325 PILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV 1384
            PI ++A+H ERLKAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV
Sbjct: 1336 PIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV 1395

Query: 1385 LLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKL 1444
            +L  IEGI GSDY+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+L
Sbjct: 1396 ILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRL 1455

Query: 1445 EERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFT 1504
            EE+SR+KCDQYWP+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFT
Sbjct: 1456 EEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFT 1515

Query: 1505 AWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEK 1564
            AWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EK
Sbjct: 1516 AWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEK 1575

Query: 1565 TVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIET 1624
            TVD+YGHVTLMR+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E 
Sbjct: 1576 TVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEP 1635

Query: 1625 GENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS 1684
            GE+VTGMELEFKRLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS
Sbjct: 1636 GEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS 1695

Query: 1685 DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQY 1744
            DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQY
Sbjct: 1696 DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQY 1755

Query: 1745 WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSG 1804
            WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSG
Sbjct: 1756 WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSG 1815

Query: 1805 EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK 1864
            EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK
Sbjct: 1816 EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK 1875

Query: 1865 MLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1899
            MLRTQRPAMVQTED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1876 MLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1910


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score = 2806 bits (7274), Expect = 0.0
 Identities = 1378/1924 (71%), Positives = 1599/1924 (83%), Gaps = 48/1924 (2%)

Query: 20   AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
            AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29   AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88

Query: 80   SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
            +VLRIQPLRTPRDE +YECVA N+VGEI+V  +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89   AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148

Query: 140  TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS---------GALQIEQSEE 190
            TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS         GALQIE SEE
Sbjct: 149  TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEE 208

Query: 191  SDQGKYECVATNSAGTRYSAPANLYVR----VRRVPPRFSIPPTNHEIMPGGSVNITCVA 246
            +DQGKYECVATNSAG RYS+PANLYVR    VRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 209  TDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVA 268

Query: 247  VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 306
            VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 269  VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 328

Query: 307  KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 366
            K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ +  Y+  + + TTRYS
Sbjct: 329  KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 388

Query: 367  VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 426
            + GLSP S+YE  V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 389  IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 448

Query: 427  EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 486
            EP EPNG I+GYRVYYTM+P   V NW KHNV DS +TT+G+L+  +TY+V+VLAFTS+G
Sbjct: 449  EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 508

Query: 487  DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 546
            DGPLS  IQV TQ GVPGQP+N +AE  SETSI LSW+PPR ++I  YEL++++G+HG E
Sbjct: 509  DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 568

Query: 547  QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 606
               T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T  +  RT+QSKPSAPPQD+ C 
Sbjct: 569  VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 628

Query: 607  SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 666
            S  ST+ILVSW+PPP E  NG +  YS++Y  +  ED +P E+ GIP  TT+ LLE LEK
Sbjct: 629  SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 688

Query: 667  WTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK 726
            WT+YRIT  AHT+VGPGPES  V++RT+EDVPS PPRKVE EA+N+T+++V WRSP P +
Sbjct: 689  WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 748

Query: 727  QHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLT 786
            QHGQIRGYQVHYVRME  E +G P +KDVMLADAQWE DDT E++M+I+ LQPET+YS+T
Sbjct: 749  QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSIT 808

Query: 787  VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTF-GPLQGYRL 845
            V AYT KGDGARSKPK+V T GAV G+P L +  T   + L +W PP  T    + GYRL
Sbjct: 809  VAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRL 868

Query: 846  KFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVP 905
            +FGR+D  PL TLEF   ED +TA+ +HKGA+YVFRL+AR++ G GEE  + +SIPE+ P
Sbjct: 869  QFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTP 928

Query: 906  TGFPQNLHSEGTTST-SVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPA-- 962
             G PQ L + G  S  +V L W PPV AERNG I KYT+  R+    L P  +  +PA  
Sbjct: 929  RGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGA-LGPARETELPAAA 987

Query: 963  ----DTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMK 1018
                +  +TL GLKPDT YD++VRAHT +GPGP+SP V++RT   DQV  KNF VK +MK
Sbjct: 988  EPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMK 1047

Query: 1019 TSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNS 1078
            TSVLLSWE P+NYNS  P+KI Y+   +  +VDGR T+KLI +LKP   Y+FVLTNRG+S
Sbjct: 1048 TSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSS 1105

Query: 1079 AGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSR 1138
             GGLQ  VTA TA ++L  KP+   K + DG I V LP+  +   ++ Y+I++VPL+KSR
Sbjct: 1106 LGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSR 1165

Query: 1139 G-KFIKPWESPDEMELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDD 1195
            G +F+ P  SP++M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP  F  GD 
Sbjct: 1166 GGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQ 1225

Query: 1196 KHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLI 1255
            K YGGF N+ L+ G  YV FVLAV++ +E   +A SP+SDP    + DPQPI D EEGLI
Sbjct: 1226 KQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLI 1284

Query: 1256 WVVGPVLAVVFIICIVIAILLYKRK----RAESDSRKSSIPNNKEIPSHHPTDPVELRRL 1311
            WV+GPVLAVVFIICIVIAILLYK K    R +S+ R   + NN ++  HHP DPVE+RR+
Sbjct: 1285 WVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRI 1344

Query: 1312 NFQTP----------------GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ 1355
            NFQTP                 M SHPPIPI ++A+H ERLKAND+LK SQEYESIDPGQ
Sbjct: 1345 NFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ 1404

Query: 1356 QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIAT 1415
            QFTWEHSNLEVNKPKNRYANVIAYDHSRV+L  IEGI GSDY+NANY+DGYR QNAYIAT
Sbjct: 1405 QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIAT 1464

Query: 1416 QGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTV 1475
            QG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QVTLLDT+
Sbjct: 1465 QGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTI 1524

Query: 1476 ELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGP 1535
            ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP
Sbjct: 1525 ELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGP 1584

Query: 1536 MVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDA 1595
            +VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY FIH+A
Sbjct: 1585 IVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEA 1644

Query: 1596 LLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPC 1655
            LLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFISANLPC
Sbjct: 1645 LLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPC 1704

Query: 1656 NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF 1715
            NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF
Sbjct: 1705 NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF 1764

Query: 1716 WRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFK 1775
            WRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFK
Sbjct: 1765 WRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFK 1824

Query: 1776 VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV 1835
            VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV
Sbjct: 1825 VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV 1884

Query: 1836 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFD 1895
            GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALEYLGSFD
Sbjct: 1885 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFD 1944

Query: 1896 HYAT 1899
            HYAT
Sbjct: 1945 HYAT 1948



 Score =  182 bits (463), Expect = 2e-45
 Identities = 215/886 (24%), Positives = 351/886 (39%), Gaps = 106/886 (11%)

Query: 16   LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75
            LR      PRF+  P+    + GG  +  C A G P P + W         Q  E +  +
Sbjct: 237  LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 288

Query: 76   DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135
            D       +  L   +D A Y CVA +++G I    ++TV    + P G P         
Sbjct: 289  DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 339

Query: 136  VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGK 195
            V E T T+  +   SGNPDP   +  ++             + + G  QI+  E+    +
Sbjct: 340  VTENTATSITITWDSGNPDPVSYYVIEYK-----------SKSQDGPYQIK--EDITTTR 386

Query: 196  YECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSV-NITCVAVGSPMPYV 254
            Y  +   S  + Y    +    + + PP  S+     E  P  +  N+    + +    V
Sbjct: 387  YS-IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIV 445

Query: 255  KWMLGAED----------LTPEDDMPIG----RNV-----LELNDVRQSANYT--CVAMS 293
            +W    E            T E + P+G     NV       +  + +   YT   +A +
Sbjct: 446  QWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFT 505

Query: 294  TLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTWDSGNPEP-VSYYIIQHKPKN 349
            ++G       I VK     PG P+   + A   TSITL+W     E  + Y ++  +  +
Sbjct: 506  SVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDH 565

Query: 350  SEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPR 409
              E+ +  D   TT Y V  L P ++Y FR+ A +  G G  +  V  +T +  PS+ P+
Sbjct: 566  GREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQ 623

Query: 410  DVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYY----TMDPTQHVNNWMKHNVADSQI 463
            DV+   + ST ILV W+   PE  NG + GY V Y    + DP     N +        +
Sbjct: 624  DVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILL 683

Query: 464  TTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP-GQPLNFKAEPESETSILLS 522
                 L     Y +  +A T +G GP SS + V T   VP   P   +AE  + T+I + 
Sbjct: 684  EA---LEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVL 740

Query: 523  WTPP----RSDTIANYELVYKDGEHGE-------------EQRITIEPGTSYR--LQGLK 563
            W  P    +   I  Y++ Y   E  E             + +   +    Y   +  L+
Sbjct: 741  WRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQ 800

Query: 564  PNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVE 623
            P + Y   +AA + +G GA +      T  +    P   +  T     S+L  W+PP   
Sbjct: 801  PETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEG--SLLARWEPPAGT 858

Query: 624  KQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG 683
             ++ ++  Y +++     ED  P   L  P    +Y    + K   Y   + A +  G G
Sbjct: 859  AEDQVL-GYRLQF---GREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLG 914

Query: 684  PESLSVLIRTNEDVPSGPPRKVEVEA-VNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRME 742
             E+  VL    ED P G P+ +E     ++ +V + W  PVP +++G I  Y V      
Sbjct: 915  EEAAEVL-SIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAG 973

Query: 743  NGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPK 802
               P  +  L            +   E+ + + GL+P+T+Y L V A+T +G G  S P 
Sbjct: 974  ALGPARETELPAAA--------EPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPV 1025

Query: 803  LVSTTGAVPGKPR-LVINHTQMNTALIQWHPPVDTFGPLQGYRLKF 847
               T       P+   +      + L+ W  P D +     Y++++
Sbjct: 1026 RYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFP-DNYNSPTPYKIQY 1070


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score = 2716 bits (7041), Expect = 0.0
 Identities = 1334/1897 (70%), Positives = 1567/1897 (82%), Gaps = 13/1897 (0%)

Query: 9    LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68
            L++L        ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 18   LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77

Query: 69   FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128
            FEVIEFDDG+GSVLRIQPLR  RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 78   FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137

Query: 129  DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQS 188
            DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRSGALQIE S
Sbjct: 138  DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESS 197

Query: 189  EESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVG 248
            EESDQGKYECVATNSAGTRYSAPANLYVRVRRV PRFSIPP++ E+MPGGSVN+TCVAVG
Sbjct: 198  EESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVG 257

Query: 249  SPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKA 308
            +PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+LG+IEA AQ+TVKA
Sbjct: 258  APMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKA 317

Query: 309  LPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVA 368
            LPKPP   VVTE+TATS+TLTWDSGN EPV+YY IQ++   +E  ++E+DGVATTRYS+ 
Sbjct: 318  LPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIG 377

Query: 369  GLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEP 428
            GLSP+S+Y FRV+AVN+IGRGPPSE V  +T EQAPSS PR VQARMLS++T+LVQW+ P
Sbjct: 378  GLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPP 437

Query: 429  EEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG 488
            EEPNG ++GYRVYYT D  +  N W KHN     +TT+G+L+P  TYS++VLAFT++GDG
Sbjct: 438  EEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDG 497

Query: 489  PLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQ- 547
            P S  IQV TQ GVP QP +F+AE ES+T I LSW  P  + I  YELVY   E  ++Q 
Sbjct: 498  PPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQH 557

Query: 548  RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 607
            ++T +P +SY L+ LKP++LY F+LAARS  G+G  T  I ART QS PSAPPQ + C S
Sbjct: 558  KVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVS 617

Query: 608  PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKW 667
              ST++ VSW PPP + +NG+IT+YS+ Y AVDGED   H + GI  + + + L  LEKW
Sbjct: 618  MGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKW 677

Query: 668  TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 727
            TEYR+ V AHTDVGPGPES  VL+RT+EDVPSGPPRKVEVE +NST+V V W+ PVP+KQ
Sbjct: 678  TEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQ 737

Query: 728  HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTV 787
            HGQIRGYQV YVR+ENGEP+G P+++DVMLA+AQW  +++ +++  ISGL PET+YS+TV
Sbjct: 738  HGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTV 797

Query: 788  TAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKF 847
             AYTTKGDGARSKPK+V+TTGAVPG+P ++I+ T MNTAL+QWHPP +  G L GYRL++
Sbjct: 798  AAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQY 857

Query: 848  GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTG 907
             R D     T++F + + HFT T +HKG +Y+FRL+A+N+ G GEE  KEI  PE++P+G
Sbjct: 858  CRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSG 917

Query: 908  FPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMT 967
            FPQNLH  G T+++ +L+W PPVLAERNG I  YT+++RDIN      E   +  DT  T
Sbjct: 918  FPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQ---QELQNITTDTRFT 974

Query: 968  LTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEI 1027
            LTGLKPDTTYD+KVRA TSKG GP SPS+Q RT+PV+QVFAKNF V A MKTSVLLSWE+
Sbjct: 975  LTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEV 1034

Query: 1028 PENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVT 1087
            P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P   YSFVL NRG+SAGGLQH V+
Sbjct: 1035 PDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVS 1092

Query: 1088 AKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKP-WE 1146
             +TAPD+L  KP        DG   + +P V     ++ +YI++VP+ +  G  + P W 
Sbjct: 1093 IRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWS 1152

Query: 1147 SPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAHFDVLPTEFTLGDDKHYGGFTNK 1204
            +P+E+ELDELL+ I +     R  R     LKPY+AA  DVLP  FTLGD K+Y GF N+
Sbjct: 1153 TPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNR 1212

Query: 1205 QLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLA 1263
             L     Y  FVLA + E  + K YA+SPYSD +V      Q    EE  ++WV GPVLA
Sbjct: 1213 PLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQ--QEEPEMLWVTGPVLA 1270

Query: 1264 VVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELRRLNFQTPGMASHP 1322
            V+ II IVIAILL+KRKR  S S K       K+    H +DPVE+RRLN+QTPGM  HP
Sbjct: 1271 VILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHP 1330

Query: 1323 PIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHS 1382
            PIPI +LAD+IERLKAND LKFSQEYESIDPGQQFTWE+SNLEVNKPKNRYANVIAYDHS
Sbjct: 1331 PIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHS 1390

Query: 1383 RVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMT 1442
            RV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG LPET GDFWRM+WEQR+ATVVMMT
Sbjct: 1391 RVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMT 1450

Query: 1443 KLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQ 1502
            +LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVELATY VRTFAL+K+GSSEKRE+RQFQ
Sbjct: 1451 RLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQ 1510

Query: 1503 FTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKH 1562
            F AWPDHGVPE+PTP LAFLRRVK CNP DAGPMVVHCSAGVGRTGCFIVIDAMLER+KH
Sbjct: 1511 FMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKH 1570

Query: 1563 EKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQI 1622
            EKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALLEA TCG+TEVPARNLYA+IQKL Q+
Sbjct: 1571 EKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQV 1630

Query: 1623 ETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVE 1682
              GE+VT MELEFK LASSKAHTSRFISANLPCNKFKNRLVNIMPYE TRVCLQPIRGVE
Sbjct: 1631 PPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVE 1690

Query: 1683 GSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCH 1742
            GSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWEHNSTI+VMLTKLREMGREKCH
Sbjct: 1691 GSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCH 1750

Query: 1743 QYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPK 1802
            QYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT+RQFQFTDWPEQGVPK
Sbjct: 1751 QYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPK 1810

Query: 1803 SGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQT 1862
            +GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVFITLSIVLERMRYEGVVD+FQT
Sbjct: 1811 TGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQT 1870

Query: 1863 VKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1899
            VK LRTQRPAMVQTEDQYQ  YRAALEYLGSFDHYAT
Sbjct: 1871 VKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1907


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score = 2703 bits (7007), Expect = 0.0
 Identities = 1335/1897 (70%), Positives = 1563/1897 (82%), Gaps = 22/1897 (1%)

Query: 9    LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68
            L++L        ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 18   LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77

Query: 69   FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128
            FEVIEFDDG+GSVLRIQPLR  RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 78   FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137

Query: 129  DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQS 188
            DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRSGALQIE S
Sbjct: 138  DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESS 197

Query: 189  EESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVG 248
            EESDQGKYECVATNSAGTRYSAPANLYVRVRRV PRFSIPP++ E+MPGGSVN+TCVAVG
Sbjct: 198  EESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVG 257

Query: 249  SPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKA 308
            +PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+LG+IEA AQ+TVKA
Sbjct: 258  APMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKA 317

Query: 309  LPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVA 368
            LPKPP   VVTE+TATS+TLTWDSGN EPV+YY IQ++   +E  ++E+DGVATTRYS+ 
Sbjct: 318  LPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIG 377

Query: 369  GLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEP 428
            GLSP+S+Y FRV+AVN+IGRGPPSE V  +T EQAPSS PR VQARMLS++T+LVQW+ P
Sbjct: 378  GLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPP 437

Query: 429  EEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG 488
            EEPNG ++GYRVYYT D  +  N W KHN     +TT+G+L+P  TYS++VLAFT++GDG
Sbjct: 438  EEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDG 497

Query: 489  PLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQ- 547
            P S  IQV TQ GVP QP +F+AE ES+T I LSW  P  + I  YELVY   E  ++Q 
Sbjct: 498  PPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQH 557

Query: 548  RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 607
            ++T +P +SY L+ LKP++LY F+LAARS  G+G  T  I ART QS PSAPPQ + C S
Sbjct: 558  KVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVS 617

Query: 608  PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKW 667
              ST++ VSW PPP + +NG+IT+YS+ Y AVDGED   H + GI  + + + L  LEKW
Sbjct: 618  MGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKW 677

Query: 668  TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 727
            TEYR+ V AHTDVGPGPES  VL+RT+EDVPSGPPRKVEVE +NST+V V W+ PVP+KQ
Sbjct: 678  TEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQ 737

Query: 728  HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTV 787
            HGQIRGYQV YVR+ENGEP+G P+++DVMLA+AQ    +TT     ISGL PET+YS+TV
Sbjct: 738  HGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQ----ETT-----ISGLTPETTYSVTV 788

Query: 788  TAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKF 847
             AYTTKGDGARSKPK+V+TTGAVPG+P ++I+ T MNTAL+QWHPP +  G L GYRL++
Sbjct: 789  AAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQY 848

Query: 848  GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTG 907
             R D     T++F + + HFT T +HKG +Y+FRL+A+N+ G GEE  KEI  PE++P+G
Sbjct: 849  CRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSG 908

Query: 908  FPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMT 967
            FPQNLH  G T+++ +L+W PPVLAERNG I  YT+++RDIN      E   +  DT  T
Sbjct: 909  FPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQ---QELQNITTDTRFT 965

Query: 968  LTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEI 1027
            LTGLKPDTTYD+KVRA TSKG GP SPS+Q RT+PV+QVFAKNF V A MKTSVLLSWE+
Sbjct: 966  LTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEV 1025

Query: 1028 PENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVT 1087
            P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P   YSFVL NRG+SAGGLQH V+
Sbjct: 1026 PDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVS 1083

Query: 1088 AKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKP-WE 1146
             +TAPD+L  KP        DG   + +P V     ++ +YI++VP+ +  G  + P W 
Sbjct: 1084 IRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWS 1143

Query: 1147 SPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAHFDVLPTEFTLGDDKHYGGFTNK 1204
            +P+E+ELDELL+ I +     R  R     LKPY+AA  DVLP  FTLGD K+Y GF N+
Sbjct: 1144 TPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNR 1203

Query: 1205 QLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLA 1263
             L     Y  FVLA + E  + K YA+SPYSD +V      Q    EE  ++WV GPVLA
Sbjct: 1204 PLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQ--QEEPEMLWVTGPVLA 1261

Query: 1264 VVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELRRLNFQTPGMASHP 1322
            V+ II IVIAILL+KRKR  S S K       K+    H +DPVE+RRLN+QTPGM  HP
Sbjct: 1262 VILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHP 1321

Query: 1323 PIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHS 1382
            PIPI +LAD+IERLKAND LKFSQEYESIDPGQQFTWE+SNLEVNKPKNRYANVIAYDHS
Sbjct: 1322 PIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHS 1381

Query: 1383 RVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMT 1442
            RV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG LPET GDFWRM+WEQR+ATVVMMT
Sbjct: 1382 RVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMT 1441

Query: 1443 KLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQ 1502
            +LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVELATY VRTFAL+K+GSSEKRE+RQFQ
Sbjct: 1442 RLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQ 1501

Query: 1503 FTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKH 1562
            F AWPDHGVPE+PTP LAFLRRVK CNP DAGPMVVHCSAGVGRTGCFIVIDAMLER+KH
Sbjct: 1502 FMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKH 1561

Query: 1563 EKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQI 1622
            EKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALLEA TCG+TEVPARNLYA+IQKL Q+
Sbjct: 1562 EKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQV 1621

Query: 1623 ETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVE 1682
              GE+VT MELEFK LASSKAHTSRFISANLPCNKFKNRLVNIMPYE TRVCLQPIRGVE
Sbjct: 1622 PPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVE 1681

Query: 1683 GSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCH 1742
            GSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWEHNSTI+VMLTKLREMGREKCH
Sbjct: 1682 GSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCH 1741

Query: 1743 QYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPK 1802
            QYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT+RQFQFTDWPEQGVPK
Sbjct: 1742 QYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPK 1801

Query: 1803 SGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQT 1862
            +GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVFITLSIVLERMRYEGVVD+FQT
Sbjct: 1802 TGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQT 1861

Query: 1863 VKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1899
            VK LRTQRPAMVQTEDQYQ  YRAALEYLGSFDHYAT
Sbjct: 1862 VKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1898


>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
            precursor [Homo sapiens]
          Length = 1501

 Score = 1894 bits (4905), Expect = 0.0
 Identities = 967/1208 (80%), Positives = 1022/1208 (84%), Gaps = 40/1208 (3%)

Query: 701  PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 760
            PP    V    +TS+ ++W S  P           V Y  +++     + + K++     
Sbjct: 325  PPGTPVVTESTATSITLTWDSGNPEP---------VSYYIIQHKPKNSEELYKEI----- 370

Query: 761  QWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLV-I 818
                D        ++GL P + Y   V A    G G  S+P L  T+   P   PR V  
Sbjct: 371  ----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQA 426

Query: 819  NHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT--DIHKGA 876
                  T L+QW  P +  G +QGYR+ +     + +         D    T  ++    
Sbjct: 427  RMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQK 486

Query: 877  SYVFRLSARNKVGFGE-----EMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVL 931
            +Y  ++ A   +G G      +++ +  +P     G P N  +E  + TS+ LSW PP  
Sbjct: 487  TYSVKVLAFTSIGDGPLSSDIQVITQTGVP-----GQPLNFKAEPESETSILLSWTPP-- 539

Query: 932  AERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 991
              R+  I  Y L+Y+D        +++ +   T+  L GLKP++ Y  ++ A + +G G 
Sbjct: 540  --RSDTIANYELVYKDGEHG--EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGA 595

Query: 992  YSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD 1051
             +  +  RT+    +FAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD
Sbjct: 596  STAEISARTM--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD 653

Query: 1052 GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI 1111
            GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI
Sbjct: 654  GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI 713

Query: 1112 TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR 1171
            TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR
Sbjct: 714  TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR 773

Query: 1172 EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS 1231
            EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS
Sbjct: 774  EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS 833

Query: 1232 PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSI 1291
            PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSI
Sbjct: 834  PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSI 893

Query: 1292 PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESI 1351
            PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESI
Sbjct: 894  PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESI 953

Query: 1352 DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNA 1411
            DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNA
Sbjct: 954  DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNA 1013

Query: 1412 YIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTL 1471
            YIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTL
Sbjct: 1014 YIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTL 1073

Query: 1472 LDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP 1531
            LDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP
Sbjct: 1074 LDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP 1133

Query: 1532 DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIF 1591
            DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIF
Sbjct: 1134 DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIF 1193

Query: 1592 IHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISA 1651
            IHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISA
Sbjct: 1194 IHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISA 1253

Query: 1652 NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAET 1711
            NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAET
Sbjct: 1254 NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAET 1313

Query: 1712 TEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYIL 1771
            TEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYIL
Sbjct: 1314 TEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYIL 1373

Query: 1772 REFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC 1831
            REFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC
Sbjct: 1374 REFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC 1433

Query: 1832 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1891
            SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
Sbjct: 1434 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1493

Query: 1892 GSFDHYAT 1899
            GSFDHYAT
Sbjct: 1494 GSFDHYAT 1501



 Score = 1187 bits (3072), Expect = 0.0
 Identities = 600/633 (94%), Positives = 607/633 (95%), Gaps = 16/633 (2%)

Query: 1   MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
           MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1   MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60

Query: 61  GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
           GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61  GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120

Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
           IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180

Query: 181 ---------GALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVPPRFSI 227
                    GALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVR    VRRVPPRFSI
Sbjct: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240

Query: 228 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 287
           PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300

Query: 288 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 347
           TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360

Query: 348 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 407
           KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420

Query: 408 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 467
           PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480

Query: 468 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 527
           NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540

Query: 528 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 587
           SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600

Query: 588 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPP 620
           SARTMQS  +   ++    +   TS+L+SW+ P
Sbjct: 601 SARTMQSMFA---KNFHVKAVMKTSVLLSWEIP 630



 Score =  130 bits (328), Expect = 9e-30
 Identities = 126/437 (28%), Positives = 197/437 (45%), Gaps = 46/437 (10%)

Query: 570  FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 629
            +   A S  G+  + A+I+ + +   P  P      T  ++TSI ++W     E  +  I
Sbjct: 300  YTCVAMSTLGVIEAIAQITVKALPKPPGTPV----VTESTATSITLTWDSGNPEPVSYYI 355

Query: 630  TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 689
             ++  K       ++   EI G+   TT+Y +  L  +++Y   V A  ++G GP S  V
Sbjct: 356  IQHKPK-----NSEELYKEIDGVA--TTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 408

Query: 690  LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 749
            L +T+E  PS  PR V+   ++ST++ V W+   P + +GQI+GY+V+Y  M+  +    
Sbjct: 409  LTQTSEQAPSSAPRDVQARMLSSTTILVQWKE--PEEPNGQIQGYRVYYT-MDPTQHVNN 465

Query: 750  PMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA 809
             M  +V  AD+Q     TT     I  L P+ +YS+ V A+T+ GDG  S    V T   
Sbjct: 466  WMKHNV--ADSQ----ITT-----IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTG 514

Query: 810  VPGKPRLVINHTQMNTA-LIQWHPP-VDTFGPLQGYRL--KFGRKDMEPLTTLEFSEKED 865
            VPG+P       +  T+ L+ W PP  DT   +  Y L  K G    E   T+   E   
Sbjct: 515  VPGQPLNFKAEPESETSILLSWTPPRSDT---IANYELVYKDGEHGEEQRITI---EPGT 568

Query: 866  HFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLS 925
             +    +   + Y FRL+AR+  G G     EIS    + + F +N H +    TSV LS
Sbjct: 569  SYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEIS-ARTMQSMFAKNFHVKAVMKTSVLLS 626

Query: 926  WQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHT 985
            W+ P   E       + +LY D       M + +    T   +  LKP+ +Y   V  + 
Sbjct: 627  WEIP---ENYNSAMPFKILYDDGK-----MVEEVDGRATQKLIVNLKPEKSYSF-VLTNR 677

Query: 986  SKGPGPYSPSVQFRTLP 1002
                G     V  +T P
Sbjct: 678  GNSAGGLQHRVTAKTAP 694



 Score =  102 bits (255), Expect = 3e-21
 Identities = 135/598 (22%), Positives = 237/598 (39%), Gaps = 79/598 (13%)

Query: 41  ASFICQATGDPRPKIVWNKKGKKV----SNQRFEVIEFDDGSGSVLR--IQPLRTPR-DE 93
           A+ +C A+G+P P+I W K    V    +N R + +  +   G+ +R  +Q  ++   D+
Sbjct: 143 ATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQ 202

Query: 94  AIYECVASNNVG-EISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGN 152
             YECVA+N+ G   S    L V    ++ R  P   + P    +    +  + C A G+
Sbjct: 203 GKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGS 262

Query: 153 PDPEITWF---KDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECVATNSAGTRYS 209
           P P + W    +D  P D          +  G   +E ++      Y CVA ++ G    
Sbjct: 263 PMPYVKWMLGAEDLTPED---------DMPIGRNVLELNDVRQSANYTCVAMSTLGV--- 310

Query: 210 APANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCV-AVGSPMPYVKWMLGAEDLTPEDD 268
             A   + V+ +P     PP    +    + +IT     G+P P   +++  +   P++ 
Sbjct: 311 IEAIAQITVKALPK----PPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHK---PKNS 363

Query: 269 MPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTEST------ 322
             + + +    D   +  Y+   +S     E            PP  PV+T+++      
Sbjct: 364 EELYKEI----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSS 419

Query: 323 -----------ATSITLTWDSGNPEP--------VSYYIIQHKPKNSEELYKEIDGVATT 363
                      +T+I + W     EP        V Y +   +  N+   +   D   TT
Sbjct: 420 APRDVQARMLSSTTILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT 478

Query: 364 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 423
              +  L P   Y  +V+A  +IG GP S  +   T    P   P + +A   S T+IL+
Sbjct: 479 ---IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILL 534

Query: 424 QWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT 483
            W  P      I  Y + Y     +H     +  +       +  L P   Y  ++ A +
Sbjct: 535 SWTPPRSDT--IANYELVYK--DGEHGEE-QRITIEPGTSYRLQGLKPNSLYYFRLAARS 589

Query: 484 SIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRS-DTIANYELVYKDGE 542
             G G  +++I   T   +  +  NF  +   +TS+LLSW  P + ++   ++++Y DG+
Sbjct: 590 PQGLGASTAEISARTMQSMFAK--NFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGK 647

Query: 543 HGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAS---TAEISARTMQSKPS 597
             EE        T   +  LKP   Y F L  R     G     TA+ +   +++KP+
Sbjct: 648 MVEE---VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPA 702


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
            precursor [Homo sapiens]
          Length = 1502

 Score = 1888 bits (4890), Expect = 0.0
 Identities = 967/1212 (79%), Positives = 1022/1212 (84%), Gaps = 44/1212 (3%)

Query: 701  PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 760
            PP    V    +TS+ ++W S  P           V Y  +++     + + K++     
Sbjct: 322  PPGTPVVTESTATSITLTWDSGNPEP---------VSYYIIQHKPKNSEELYKEI----- 367

Query: 761  QWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLV-I 818
                D        ++GL P + Y   V A    G G  S+P L  T+   P   PR V  
Sbjct: 368  ----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQA 423

Query: 819  NHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT--DIHKGA 876
                  T L+QW  P +  G +QGYR+ +     + +         D    T  ++    
Sbjct: 424  RMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQK 483

Query: 877  SYVFRLSARNKVGFGE-----EMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVL 931
            +Y  ++ A   +G G      +++ +  +P     G P N  +E  + TS+ LSW PP  
Sbjct: 484  TYSVKVLAFTSIGDGPLSSDIQVITQTGVP-----GQPLNFKAEPESETSILLSWTPP-- 536

Query: 932  AERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 991
              R+  I  Y L+Y+D        +++ +   T+  L GLKP++ Y  ++ A + +G G 
Sbjct: 537  --RSDTIANYELVYKDGEHG--EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGA 592

Query: 992  YSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD 1051
             +  +  RT+    +FAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD
Sbjct: 593  STAEISARTM--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD 650

Query: 1052 GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI 1111
            GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI
Sbjct: 651  GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI 710

Query: 1112 TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR 1171
            TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR
Sbjct: 711  TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR 770

Query: 1172 EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS 1231
            EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS
Sbjct: 771  EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS 830

Query: 1232 PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYK----RKRAESDSR 1287
            PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYK    RKRAESDSR
Sbjct: 831  PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSR 890

Query: 1288 KSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQE 1347
            KSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQE
Sbjct: 891  KSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQE 950

Query: 1348 YESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYR 1407
            YESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYR
Sbjct: 951  YESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYR 1010

Query: 1408 KQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLV 1467
            KQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLV
Sbjct: 1011 KQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLV 1070

Query: 1468 QVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT 1527
            QVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT
Sbjct: 1071 QVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT 1130

Query: 1528 CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTED 1587
            CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTED
Sbjct: 1131 CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTED 1190

Query: 1588 QYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSR 1647
            QYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSR
Sbjct: 1191 QYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSR 1250

Query: 1648 FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP 1707
            FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP
Sbjct: 1251 FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP 1310

Query: 1708 LAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMP 1767
            LAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMP
Sbjct: 1311 LAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMP 1370

Query: 1768 QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1827
            QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI
Sbjct: 1371 QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1430

Query: 1828 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1887
            SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA
Sbjct: 1431 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1490

Query: 1888 LEYLGSFDHYAT 1899
            LEYLGSFDHYAT
Sbjct: 1491 LEYLGSFDHYAT 1502



 Score = 1189 bits (3075), Expect = 0.0
 Identities = 600/630 (95%), Positives = 607/630 (96%), Gaps = 13/630 (2%)

Query: 1   MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
           MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1   MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60

Query: 61  GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
           GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61  GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120

Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
           IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180

Query: 181 G------ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVPPRFSIPPT 230
           G      ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVR    VRRVPPRFSIPPT
Sbjct: 181 GGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPT 240

Query: 231 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCV 290
           NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCV
Sbjct: 241 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCV 300

Query: 291 AMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNS 350
           AMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNS
Sbjct: 301 AMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNS 360

Query: 351 EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 410
           EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD
Sbjct: 361 EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 420

Query: 411 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 470
           VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV
Sbjct: 421 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 480

Query: 471 PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDT 530
           PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDT
Sbjct: 481 PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDT 540

Query: 531 IANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISAR 590
           IANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISAR
Sbjct: 541 IANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISAR 600

Query: 591 TMQSKPSAPPQDISCTSPSSTSILVSWQPP 620
           TMQS  +   ++    +   TS+L+SW+ P
Sbjct: 601 TMQSMFA---KNFHVKAVMKTSVLLSWEIP 627



 Score =  130 bits (328), Expect = 9e-30
 Identities = 126/437 (28%), Positives = 197/437 (45%), Gaps = 46/437 (10%)

Query: 570  FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 629
            +   A S  G+  + A+I+ + +   P  P      T  ++TSI ++W     E  +  I
Sbjct: 297  YTCVAMSTLGVIEAIAQITVKALPKPPGTPV----VTESTATSITLTWDSGNPEPVSYYI 352

Query: 630  TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 689
             ++  K       ++   EI G+   TT+Y +  L  +++Y   V A  ++G GP S  V
Sbjct: 353  IQHKPK-----NSEELYKEIDGVA--TTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 405

Query: 690  LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 749
            L +T+E  PS  PR V+   ++ST++ V W+   P + +GQI+GY+V+Y  M+  +    
Sbjct: 406  LTQTSEQAPSSAPRDVQARMLSSTTILVQWKE--PEEPNGQIQGYRVYYT-MDPTQHVNN 462

Query: 750  PMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA 809
             M  +V  AD+Q     TT     I  L P+ +YS+ V A+T+ GDG  S    V T   
Sbjct: 463  WMKHNV--ADSQ----ITT-----IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTG 511

Query: 810  VPGKPRLVINHTQMNTA-LIQWHPP-VDTFGPLQGYRL--KFGRKDMEPLTTLEFSEKED 865
            VPG+P       +  T+ L+ W PP  DT   +  Y L  K G    E   T+   E   
Sbjct: 512  VPGQPLNFKAEPESETSILLSWTPPRSDT---IANYELVYKDGEHGEEQRITI---EPGT 565

Query: 866  HFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLS 925
             +    +   + Y FRL+AR+  G G     EIS    + + F +N H +    TSV LS
Sbjct: 566  SYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEIS-ARTMQSMFAKNFHVKAVMKTSVLLS 623

Query: 926  WQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHT 985
            W+ P   E       + +LY D       M + +    T   +  LKP+ +Y   V  + 
Sbjct: 624  WEIP---ENYNSAMPFKILYDDGK-----MVEEVDGRATQKLIVNLKPEKSYSF-VLTNR 674

Query: 986  SKGPGPYSPSVQFRTLP 1002
                G     V  +T P
Sbjct: 675  GNSAGGLQHRVTAKTAP 691



 Score =  102 bits (254), Expect = 4e-21
 Identities = 135/596 (22%), Positives = 233/596 (39%), Gaps = 78/596 (13%)

Query: 41  ASFICQATGDPRPKIVWNKKGKKV--SNQRFEVIEFDDGSGSV---LRIQPLRTPRDEAI 95
           A+ +C A+G+P P+I W K    V  SN    + +   G   +   L+I+      D+  
Sbjct: 143 ATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSEES-DQGK 201

Query: 96  YECVASNNVG-EISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPD 154
           YECVA+N+ G   S    L V    ++ R  P   + P    +    +  + C A G+P 
Sbjct: 202 YECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM 261

Query: 155 PEITWF---KDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECVATNSAGTRYSAP 211
           P + W    +D  P D          +  G   +E ++      Y CVA ++ G      
Sbjct: 262 PYVKWMLGAEDLTPED---------DMPIGRNVLELNDVRQSANYTCVAMSTLGV---IE 309

Query: 212 ANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCV-AVGSPMPYVKWMLGAEDLTPEDDMP 270
           A   + V+ +P     PP    +    + +IT     G+P P   +++  +   P++   
Sbjct: 310 AIAQITVKALPK----PPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHK---PKNSEE 362

Query: 271 IGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTEST-------- 322
           + + +    D   +  Y+   +S     E            PP  PV+T+++        
Sbjct: 363 LYKEI----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAP 418

Query: 323 ---------ATSITLTWDSGNPEP--------VSYYIIQHKPKNSEELYKEIDGVATTRY 365
                    +T+I + W     EP        V Y +   +  N+   +   D   TT  
Sbjct: 419 RDVQARMLSSTTILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT-- 475

Query: 366 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 425
            +  L P   Y  +V+A  +IG GP S  +   T    P   P + +A   S T+IL+ W
Sbjct: 476 -IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSW 533

Query: 426 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 485
             P      I  Y + Y     +H     +  +       +  L P   Y  ++ A +  
Sbjct: 534 TPPRSDT--IANYELVYK--DGEHGEE-QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQ 588

Query: 486 GDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRS-DTIANYELVYKDGEHG 544
           G G  +++I   T   +  +  NF  +   +TS+LLSW  P + ++   ++++Y DG+  
Sbjct: 589 GLGASTAEISARTMQSMFAK--NFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMV 646

Query: 545 EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAS---TAEISARTMQSKPS 597
           EE        T   +  LKP   Y F L  R     G     TA+ +   +++KP+
Sbjct: 647 EE---VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPA 699


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
            isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score = 1541 bits (3989), Expect = 0.0
 Identities = 798/1223 (65%), Positives = 939/1223 (76%), Gaps = 51/1223 (4%)

Query: 693  TNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPML 752
            T + +P  P   +  E   +TS+ ++W S  P+     +  Y + Y   ++    G   +
Sbjct: 318  TVKSLPKAPGTPMVTENT-ATSITITWDSGNPDP----VSYYVIEY---KSKSQDGPYQI 369

Query: 753  KDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 812
            K+           D T     I GL P + Y + V+A  + G G  S+  +  T    P 
Sbjct: 370  KE-----------DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPA 418

Query: 813  K-PRLV-INHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT 870
              PR V        T ++QW  PV+  G ++GYR+ +  +   P+   +    +D    T
Sbjct: 419  SAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT 478

Query: 871  --DIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT-----GFPQNLHSEGTTSTSVQ 923
               + +  +Y  R+ A   VG G      +S P +V T     G P NL +E  + TS+ 
Sbjct: 479  VGSLLEDETYTVRVLAFTSVGDGP-----LSDPIQVKTQQGVPGQPMNLRAEARSETSIT 533

Query: 924  LSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRA 983
            LSW PP    R   I KY LL+R+ +     + +   P  T+  +  LKP+T Y  ++ A
Sbjct: 534  LSWSPP----RQESIIKYELLFREGDHGR-EVGRTFDPT-TSYVVEDLKPNTEYAFRLAA 587

Query: 984  HTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDD 1043
             + +G G ++P V+ RTL    +  KNF VK +MKTSVLLSWE P+NYNS  P+KI Y+ 
Sbjct: 588  RSPQGLGAFTPVVRQRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG 645

Query: 1044 GKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIG 1103
              +  +VDGR T+KLI +LKP   Y+FVLTNRG+S GGLQ  VTA TA ++L  KP+   
Sbjct: 646  --LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP 703

Query: 1104 KTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR 1162
            K + DG I V LP+  +   ++ Y+I++VPL+KSRG +F+ P  SP++M+L+EL+++ISR
Sbjct: 704  KPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISR 763

Query: 1163 -KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM 1220
             +RRS+R+ R++E+ +PYIAA F VLP  F  GD K YGGF N+ L+ G  YV FVLAV+
Sbjct: 764  LQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVL 823

Query: 1221 EHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRK 1280
            + +E   +A SP+SDP    + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK K
Sbjct: 824  QKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK 882

Query: 1281 ----RAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERL 1336
                R +S+ R   + NN ++  HHP DPVE+RR+NFQTPGM SHPPIPI ++A+H ERL
Sbjct: 883  PDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERL 942

Query: 1337 KANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSD 1396
            KAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV+L  IEGI GSD
Sbjct: 943  KANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSD 1002

Query: 1397 YVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYW 1456
            Y+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYW
Sbjct: 1003 YINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYW 1062

Query: 1457 PSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPT 1516
            P+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PT
Sbjct: 1063 PNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPT 1122

Query: 1517 PFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMR 1576
            PFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR
Sbjct: 1123 PFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMR 1182

Query: 1577 AQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFK 1636
            +QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFK
Sbjct: 1183 SQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFK 1242

Query: 1637 RLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1696
            RLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR
Sbjct: 1243 RLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1302

Query: 1697 QQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1756
            QQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYF
Sbjct: 1303 QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1362

Query: 1757 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1816
            VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK
Sbjct: 1363 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1422

Query: 1817 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1876
            TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT
Sbjct: 1423 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1482

Query: 1877 EDQYQFSYRAALEYLGSFDHYAT 1899
            ED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1483 EDEYQFCYQAALEYLGSFDHYAT 1505



 Score =  897 bits (2317), Expect = 0.0
 Identities = 444/660 (67%), Positives = 531/660 (80%), Gaps = 19/660 (2%)

Query: 20  AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
           AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29  AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88

Query: 80  SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
           +VLRIQPLRTPRDE +YECVA N+VGEI+V  +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89  AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148

Query: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECV 199
           TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRSGALQIE SEE+DQGKYECV
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECV 208

Query: 200 ATNSAGTRYSAPANLYVR----VRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVK 255
           ATNSAG RYS+PANLYVR    VRRV PRFSI P +HEIMPGG+VNITCVAVGSPMPYVK
Sbjct: 209 ATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK 268

Query: 256 WMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGT 315
           WM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITVK+LPK PGT
Sbjct: 269 WMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGT 328

Query: 316 PVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSD 375
           P+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ +  Y+  + + TTRYS+ GLSP S+
Sbjct: 329 PMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSE 388

Query: 376 YEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQI 435
           YE  V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+EP EPNG I
Sbjct: 389 YEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLI 448

Query: 436 QGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQ 495
           +GYRVYYTM+P   V NW KHNV DS +TT+G+L+  +TY+V+VLAFTS+GDGPLS  IQ
Sbjct: 449 RGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQ 508

Query: 496 VITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGT 555
           V TQ GVPGQP+N +AE  SETSI LSW+PPR ++I  YEL++++G+HG E   T +P T
Sbjct: 509 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 568

Query: 556 SYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILV 615
           SY ++ LKPN+ Y FRLAARSPQGLGA T  +  RT+Q   S  P++        TS+L+
Sbjct: 569 SYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ---SISPKNFKVKMIMKTSVLL 625

Query: 616 SWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVT 675
           SW+ P  +  N   T Y I+Y  +          L +   TTK L+  L+  T Y   +T
Sbjct: 626 SWEFP--DNYNS-PTPYKIQYNGL---------TLDVDGRTTKKLITHLKPHTFYNFVLT 673



 Score =  129 bits (325), Expect = 2e-29
 Identities = 113/412 (27%), Positives = 182/412 (44%), Gaps = 45/412 (10%)

Query: 570 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 629
           +   A S  G+  + A+I+ +++   P  P      T  ++TSI ++W     +  +  +
Sbjct: 300 YTCVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITWDSGNPDPVSYYV 355

Query: 630 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 689
            EY  K        D P++I      TT+Y +  L   +EY I V+A   +G GP S SV
Sbjct: 356 IEYKSK------SQDGPYQIKE-DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESV 408

Query: 690 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 749
           + RT E  P+  PR V+   +++T++ V W  PV  + +G IRGY+V+Y  ME   P G 
Sbjct: 409 VTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRVYYT-MEPEHPVGN 465

Query: 750 PMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA 809
               +V         DD+      +  L  + +Y++ V A+T+ GDG  S P  V T   
Sbjct: 466 WQKHNV---------DDSLL--TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG 514

Query: 810 VPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFT 868
           VPG+P  +    +  T++ + W PP      +  Y L F   D        F +    + 
Sbjct: 515 VPGQPMNLRAEARSETSITLSWSPPRQE--SIIKYELLFREGDHGREVGRTF-DPTTSYV 571

Query: 869 ATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSW 926
             D+     Y FRL+AR+  G G    +V++ ++    P  F   +       TSV LSW
Sbjct: 572 VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKM----IMKTSVLLSW 627

Query: 927 QPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYD 978
           + P   +     T Y + Y  + +        +    T   +T LKP T Y+
Sbjct: 628 EFP---DNYNSPTPYKIQYNGLTLD-------VDGRTTKKLITHLKPHTFYN 669



 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 110/453 (24%), Positives = 184/453 (40%), Gaps = 63/453 (13%)

Query: 16  LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75
           LR      PRF+  P+    + GG  +  C A G P P + W         Q  E +  +
Sbjct: 228 LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 279

Query: 76  DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135
           D       +  L   +D A Y CVA +++G I    ++TV    + P G P         
Sbjct: 280 DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 330

Query: 136 VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGK 195
           V E T T+  +   SGNPDP   +  ++             + + G  QI+  E+    +
Sbjct: 331 VTENTATSITITWDSGNPDPVSYYVIEYK-----------SKSQDGPYQIK--EDITTTR 377

Query: 196 YECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSV-NITCVAVGSPMPYV 254
           Y  +   S  + Y    +    + + PP  S+     E  P  +  N+    + +    V
Sbjct: 378 YS-IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIV 436

Query: 255 KWMLGAED----------LTPEDDMPIG----RNV-----LELNDVRQSANYT--CVAMS 293
           +W    E            T E + P+G     NV       +  + +   YT   +A +
Sbjct: 437 QWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFT 496

Query: 294 TLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTWDSGNPEP-VSYYIIQHKPKN 349
           ++G       I VK     PG P+   + A   TSITL+W     E  + Y ++  +  +
Sbjct: 497 SVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDH 556

Query: 350 SEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPR 409
             E+ +  D   TT Y V  L P ++Y FR+ A +  G G    PV+ Q + Q  S +P+
Sbjct: 557 GREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLG-AFTPVVRQRTLQ--SISPK 611

Query: 410 DVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY 442
           + + +M+  T++L+ W+ P+  N     Y++ Y
Sbjct: 612 NFKVKMIMKTSVLLSWEFPDNYNSPTP-YKIQY 643


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
            isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score = 1541 bits (3989), Expect = 0.0
 Identities = 798/1223 (65%), Positives = 939/1223 (76%), Gaps = 51/1223 (4%)

Query: 693  TNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPML 752
            T + +P  P   +  E   +TS+ ++W S  P+     +  Y + Y   ++    G   +
Sbjct: 314  TVKSLPKAPGTPMVTENT-ATSITITWDSGNPDP----VSYYVIEY---KSKSQDGPYQI 365

Query: 753  KDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 812
            K+           D T     I GL P + Y + V+A  + G G  S+  +  T    P 
Sbjct: 366  KE-----------DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPA 414

Query: 813  K-PRLV-INHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT 870
              PR V        T ++QW  PV+  G ++GYR+ +  +   P+   +    +D    T
Sbjct: 415  SAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT 474

Query: 871  --DIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT-----GFPQNLHSEGTTSTSVQ 923
               + +  +Y  R+ A   VG G      +S P +V T     G P NL +E  + TS+ 
Sbjct: 475  VGSLLEDETYTVRVLAFTSVGDGP-----LSDPIQVKTQQGVPGQPMNLRAEARSETSIT 529

Query: 924  LSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRA 983
            LSW PP    R   I KY LL+R+ +     + +   P  T+  +  LKP+T Y  ++ A
Sbjct: 530  LSWSPP----RQESIIKYELLFREGDHGR-EVGRTFDPT-TSYVVEDLKPNTEYAFRLAA 583

Query: 984  HTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDD 1043
             + +G G ++P V+ RTL    +  KNF VK +MKTSVLLSWE P+NYNS  P+KI Y+ 
Sbjct: 584  RSPQGLGAFTPVVRQRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG 641

Query: 1044 GKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIG 1103
              +  +VDGR T+KLI +LKP   Y+FVLTNRG+S GGLQ  VTA TA ++L  KP+   
Sbjct: 642  --LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP 699

Query: 1104 KTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR 1162
            K + DG I V LP+  +   ++ Y+I++VPL+KSRG +F+ P  SP++M+L+EL+++ISR
Sbjct: 700  KPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISR 759

Query: 1163 -KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM 1220
             +RRS+R+ R++E+ +PYIAA F VLP  F  GD K YGGF N+ L+ G  YV FVLAV+
Sbjct: 760  LQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVL 819

Query: 1221 EHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRK 1280
            + +E   +A SP+SDP    + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK K
Sbjct: 820  QKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK 878

Query: 1281 ----RAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERL 1336
                R +S+ R   + NN ++  HHP DPVE+RR+NFQTPGM SHPPIPI ++A+H ERL
Sbjct: 879  PDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERL 938

Query: 1337 KANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSD 1396
            KAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV+L  IEGI GSD
Sbjct: 939  KANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSD 998

Query: 1397 YVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYW 1456
            Y+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYW
Sbjct: 999  YINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYW 1058

Query: 1457 PSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPT 1516
            P+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PT
Sbjct: 1059 PNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPT 1118

Query: 1517 PFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMR 1576
            PFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR
Sbjct: 1119 PFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMR 1178

Query: 1577 AQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFK 1636
            +QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFK
Sbjct: 1179 SQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFK 1238

Query: 1637 RLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1696
            RLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR
Sbjct: 1239 RLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1298

Query: 1697 QQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1756
            QQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYF
Sbjct: 1299 QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1358

Query: 1757 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1816
            VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK
Sbjct: 1359 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1418

Query: 1817 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1876
            TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT
Sbjct: 1419 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1478

Query: 1877 EDQYQFSYRAALEYLGSFDHYAT 1899
            ED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1479 EDEYQFCYQAALEYLGSFDHYAT 1501



 Score =  902 bits (2332), Expect = 0.0
 Identities = 444/656 (67%), Positives = 531/656 (80%), Gaps = 15/656 (2%)

Query: 20  AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
           AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29  AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88

Query: 80  SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
           +VLRIQPLRTPRDE +YECVA N+VGEI+V  +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89  AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148

Query: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECV 199
           TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRSGALQIE SEE+DQGKYECV
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECV 208

Query: 200 ATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLG 259
           ATNSAG RYS+PANLYVRVRRV PRFSI P +HEIMPGG+VNITCVAVGSPMPYVKWM G
Sbjct: 209 ATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQG 268

Query: 260 AEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVT 319
           AEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITVK+LPK PGTP+VT
Sbjct: 269 AEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVT 328

Query: 320 ESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFR 379
           E+TATSIT+TWDSGNP+PVSYY+I++K K+ +  Y+  + + TTRYS+ GLSP S+YE  
Sbjct: 329 ENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIW 388

Query: 380 VVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYR 439
           V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+EP EPNG I+GYR
Sbjct: 389 VSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYR 448

Query: 440 VYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQ 499
           VYYTM+P   V NW KHNV DS +TT+G+L+  +TY+V+VLAFTS+GDGPLS  IQV TQ
Sbjct: 449 VYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQ 508

Query: 500 TGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRL 559
            GVPGQP+N +AE  SETSI LSW+PPR ++I  YEL++++G+HG E   T +P TSY +
Sbjct: 509 QGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVV 568

Query: 560 QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQP 619
           + LKPN+ Y FRLAARSPQGLGA T  +  RT+Q   S  P++        TS+L+SW+ 
Sbjct: 569 EDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ---SISPKNFKVKMIMKTSVLLSWEF 625

Query: 620 PPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVT 675
           P  +  N   T Y I+Y  +          L +   TTK L+  L+  T Y   +T
Sbjct: 626 P--DNYNS-PTPYKIQYNGL---------TLDVDGRTTKKLITHLKPHTFYNFVLT 669



 Score =  129 bits (325), Expect = 2e-29
 Identities = 113/412 (27%), Positives = 182/412 (44%), Gaps = 45/412 (10%)

Query: 570 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 629
           +   A S  G+  + A+I+ +++   P  P      T  ++TSI ++W     +  +  +
Sbjct: 296 YTCVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITWDSGNPDPVSYYV 351

Query: 630 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 689
            EY  K        D P++I      TT+Y +  L   +EY I V+A   +G GP S SV
Sbjct: 352 IEYKSK------SQDGPYQIKE-DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESV 404

Query: 690 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 749
           + RT E  P+  PR V+   +++T++ V W  PV  + +G IRGY+V+Y  ME   P G 
Sbjct: 405 VTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRVYYT-MEPEHPVGN 461

Query: 750 PMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA 809
               +V         DD+      +  L  + +Y++ V A+T+ GDG  S P  V T   
Sbjct: 462 WQKHNV---------DDSLL--TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG 510

Query: 810 VPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFT 868
           VPG+P  +    +  T++ + W PP      +  Y L F   D        F +    + 
Sbjct: 511 VPGQPMNLRAEARSETSITLSWSPPRQE--SIIKYELLFREGDHGREVGRTF-DPTTSYV 567

Query: 869 ATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSW 926
             D+     Y FRL+AR+  G G    +V++ ++    P  F   +       TSV LSW
Sbjct: 568 VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKM----IMKTSVLLSW 623

Query: 927 QPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYD 978
           + P   +     T Y + Y  + +        +    T   +T LKP T Y+
Sbjct: 624 EFP---DNYNSPTPYKIQYNGLTLD-------VDGRTTKKLITHLKPHTFYN 665


>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
            precursor [Homo sapiens]
          Length = 802

 Score =  602 bits (1552), Expect = e-171
 Identities = 312/681 (45%), Positives = 431/681 (63%), Gaps = 13/681 (1%)

Query: 1225 SKMYATSPYSDPVVSMDLDPQPITDEEE--GLIWVVGPVLAVVFIICIVIAILLYKRKRA 1282
            S   AT+P + P  S + D +   DE     ++  +  +L +VFII ++  +   K K+A
Sbjct: 125  SSTAATTPETFPP-SGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQA 183

Query: 1283 ESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNL 1342
             S S    + N +        +P  +  L         +PP+P+ +L + I R  A+DN 
Sbjct: 184  GSHSNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNK 239

Query: 1343 KFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNAN 1401
             F +E+ ++     Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA+
Sbjct: 240  LFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINAS 299

Query: 1402 YIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGT 1461
            +I+GY+++N +IA QG   ET  DFWRMIWEQ +AT+VM+T L+ER   KC QYWP +G 
Sbjct: 300  FINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGC 359

Query: 1462 ETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTP 1517
             T+G ++V++ D   L  Y VR F + + G    R+    + QF FT+WPD GVP  P  
Sbjct: 360  WTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIG 419

Query: 1518 FLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRA 1577
             L FL++VK CNP  AG +VVHCSAGVGRTG F+VIDAML+ +  E+ VD+YG V+ +RA
Sbjct: 420  MLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRA 479

Query: 1578 QRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKR 1637
            QR  MVQT+ QY+FI+ ALLE    G+TE+   +L  ++QK+     G +  G+E EFK+
Sbjct: 480  QRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKK 539

Query: 1638 LASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQ 1697
            L S K    +  + NLP N  KNR++ I+PYE  RV +   RG E +DY+NASFIDGYRQ
Sbjct: 540  LTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQ 599

Query: 1698 QKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFV 1757
            + +YIA+QGPL  T EDFWRM+WE  S  +VMLT+L E G+EKC QYWP++    Y    
Sbjct: 600  KDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDIT 659

Query: 1758 VDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKT 1817
            V+   E     Y +R+  VT+ R+ +SR +RQF F  WPE G+P  G+G I  I  V K 
Sbjct: 660  VELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQ 719

Query: 1818 KEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTE 1877
            ++Q G + PI+VHCSAG GRTG F  LS VLER++ EG++D+FQTVK LR QRP MVQT 
Sbjct: 720  QQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTL 778

Query: 1878 DQYQFSYRAALEYLGSFDHYA 1898
            +QY+F Y+   EY+ +F  YA
Sbjct: 779  EQYEFCYKVVQEYIDAFSDYA 799


>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  601 bits (1550), Expect = e-171
 Identities = 311/679 (45%), Positives = 428/679 (63%), Gaps = 18/679 (2%)

Query: 1225 SKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAES 1284
            S   AT+P + P      D  PI      ++  +  +L +VFII ++  +   K K+A S
Sbjct: 125  SSTAATTPETFP----PSDETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGS 176

Query: 1285 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 1344
             S    + N +        +P  +  L         +PP+P+ +L + I R  A+DN  F
Sbjct: 177  HSNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLF 232

Query: 1345 SQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYI 1403
             +E+ ++     Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA++I
Sbjct: 233  REEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFI 292

Query: 1404 DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTET 1463
            +GY+++N +IA QG   ET  DFWRMIWEQ +AT+VM+T L+ER   KC QYWP +G  T
Sbjct: 293  NGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWT 352

Query: 1464 HGLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFL 1519
            +G ++V++ D   L  Y VR F + + G    R+    + QF FT+WPD GVP  P   L
Sbjct: 353  YGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGML 412

Query: 1520 AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQR 1579
             FL++VK CNP  AG +VVHCSAGVGRTG F+VIDAML+ +  E+ VD+YG V+ +RAQR
Sbjct: 413  KFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQR 472

Query: 1580 NYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLA 1639
              MVQT+ QY+FI+ ALLE    G+TE+   +L  ++QK+     G +  G+E EFK+L 
Sbjct: 473  CQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLT 532

Query: 1640 SSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQK 1699
            S K    +  + NLP N  KNR++ I+PYE  RV +   RG E +DY+NASFIDGYRQ+ 
Sbjct: 533  SIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKD 592

Query: 1700 AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVD 1759
            +YIA+QGPL  T EDFWRM+WE  S  +VMLT+L E G+EKC QYWP++    Y    V+
Sbjct: 593  SYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVE 652

Query: 1760 PMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKE 1819
               E     Y +R+  VT+ R+ +SR +RQF F  WPE G+P  G+G I  I  V K ++
Sbjct: 653  LKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQ 712

Query: 1820 QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQ 1879
            Q G + PI+VHCSAG GRTG F  LS VLER++ EG++D+FQTVK LR QRP MVQT +Q
Sbjct: 713  QSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771

Query: 1880 YQFSYRAALEYLGSFDHYA 1898
            Y+F Y+   EY+ +F  YA
Sbjct: 772  YEFCYKVVQEYIDAFSDYA 790


>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  601 bits (1550), Expect = e-171
 Identities = 311/679 (45%), Positives = 428/679 (63%), Gaps = 18/679 (2%)

Query: 1225 SKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAES 1284
            S   AT+P + P      D  PI      ++  +  +L +VFII ++  +   K K+A S
Sbjct: 125  SSTAATTPETFP----PSDETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGS 176

Query: 1285 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 1344
             S    + N +        +P  +  L         +PP+P+ +L + I R  A+DN  F
Sbjct: 177  HSNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLF 232

Query: 1345 SQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYI 1403
             +E+ ++     Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA++I
Sbjct: 233  REEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFI 292

Query: 1404 DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTET 1463
            +GY+++N +IA QG   ET  DFWRMIWEQ +AT+VM+T L+ER   KC QYWP +G  T
Sbjct: 293  NGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWT 352

Query: 1464 HGLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFL 1519
            +G ++V++ D   L  Y VR F + + G    R+    + QF FT+WPD GVP  P   L
Sbjct: 353  YGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGML 412

Query: 1520 AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQR 1579
             FL++VK CNP  AG +VVHCSAGVGRTG F+VIDAML+ +  E+ VD+YG V+ +RAQR
Sbjct: 413  KFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQR 472

Query: 1580 NYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLA 1639
              MVQT+ QY+FI+ ALLE    G+TE+   +L  ++QK+     G +  G+E EFK+L 
Sbjct: 473  CQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLT 532

Query: 1640 SSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQK 1699
            S K    +  + NLP N  KNR++ I+PYE  RV +   RG E +DY+NASFIDGYRQ+ 
Sbjct: 533  SIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKD 592

Query: 1700 AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVD 1759
            +YIA+QGPL  T EDFWRM+WE  S  +VMLT+L E G+EKC QYWP++    Y    V+
Sbjct: 593  SYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVE 652

Query: 1760 PMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKE 1819
               E     Y +R+  VT+ R+ +SR +RQF F  WPE G+P  G+G I  I  V K ++
Sbjct: 653  LKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQ 712

Query: 1820 QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQ 1879
            Q G + PI+VHCSAG GRTG F  LS VLER++ EG++D+FQTVK LR QRP MVQT +Q
Sbjct: 713  QSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771

Query: 1880 YQFSYRAALEYLGSFDHYA 1898
            Y+F Y+   EY+ +F  YA
Sbjct: 772  YEFCYKVVQEYIDAFSDYA 790


>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
            precursor [Homo sapiens]
          Length = 700

 Score =  556 bits (1433), Expect = e-158
 Identities = 294/655 (44%), Positives = 411/655 (62%), Gaps = 15/655 (2%)

Query: 1254 LIWVVGPVLAVVFIICIVIAILLYKRKR-AESDSRKSSIPNNKEIPSHHPTDPVELRRLN 1312
            L W++ P+L ++ ++ +      ++++R A   +    +PN   I        V L  L+
Sbjct: 48   LAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKMPNG--ILEEQEQQRVML--LS 103

Query: 1313 FQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKN 1371
                G   + PIP+  L + I    A+D  +F +E+ S+  G  Q T+E +N E N+ KN
Sbjct: 104  RSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKN 163

Query: 1372 RYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIW 1431
            RY N++  DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG   ET  DFWRM+W
Sbjct: 164  RYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVW 223

Query: 1432 EQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK-- 1489
            EQ+SAT+VM+T L+ER   KC QYWP +G  T+G ++V + D V L  Y +R F +    
Sbjct: 224  EQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQL 283

Query: 1490 -NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1548
             +G    R V Q  FT+WPD GVP  P   L FL++VKT NP  AGP+VVHCSAGVGRTG
Sbjct: 284  PDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTG 343

Query: 1549 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVP 1608
             FIVIDAM+  +  E+ VD++  V+ +R QR  MVQT+ QY FI+ ALLE    G+TE+ 
Sbjct: 344  TFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELD 403

Query: 1609 ARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPY 1668
              +L  ++Q +    T  +  G+E EF++L + +       + NLP N  K R++ I+PY
Sbjct: 404  VSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPY 463

Query: 1669 ESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVV 1728
            +  RV L   RG E +DYINASFIDGYRQ+  +IATQGPLA T EDFWRM+WE  S  +V
Sbjct: 464  DFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIV 523

Query: 1729 MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQ 1783
            MLT+++E  ++KC+QYWP E S  +    ++   +       +R+F VT       ++ Q
Sbjct: 524  MLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQ 583

Query: 1784 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFIT 1843
             R VRQF F  WPE G+P  G+G ID I  V K ++Q G + PI+VHCSAG GRTG FI 
Sbjct: 584  VRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIA 642

Query: 1844 LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1898
            LS +LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+   +++  F  YA
Sbjct: 643  LSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 697


>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
            [Homo sapiens]
          Length = 642

 Score =  550 bits (1416), Expect = e-156
 Identities = 282/591 (47%), Positives = 384/591 (64%), Gaps = 10/591 (1%)

Query: 1317 GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYAN 1375
            G   + PIP+  L + I    A+D  +F +E+ S+  G  Q T+E +N E N+ KNRY N
Sbjct: 50   GPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPN 109

Query: 1376 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1435
            ++  DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG   ET  DFWRM+WEQ+S
Sbjct: 110  ILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKS 169

Query: 1436 ATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK---NGS 1492
            AT+VM+T L+ER   KC QYWP +G  T+G ++V + D V L  Y +R F +     +G 
Sbjct: 170  ATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGC 229

Query: 1493 SEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIV 1552
               R V Q  FT+WPD GVP  P   L FL++VKT NP  AGP+VVHCSAGVGRTG FIV
Sbjct: 230  KAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIV 289

Query: 1553 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNL 1612
            IDAM+  +  E+ VD++  V+ +R QR  MVQT+ QY FI+ ALLE    G+TE+   +L
Sbjct: 290  IDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSL 349

Query: 1613 YAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTR 1672
              ++Q +    T  +  G+E EF++L + +       + NLP N  K R++ I+PY+  R
Sbjct: 350  EKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNR 409

Query: 1673 VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK 1732
            V L   RG E +DYINASFIDGYRQ+  +IATQGPLA T EDFWRM+WE  S  +VMLT+
Sbjct: 410  VILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTE 469

Query: 1733 LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTV 1787
            ++E  ++KC+QYWP E S  +    ++   +       +R+F VT       ++ Q R V
Sbjct: 470  VQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVV 529

Query: 1788 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1847
            RQF F  WPE G+P  G+G ID I  V K ++Q G + PI+VHCSAG GRTG FI LS +
Sbjct: 530  RQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNI 588

Query: 1848 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1898
            LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+   +++  F  YA
Sbjct: 589  LERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639


>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
            [Homo sapiens]
          Length = 1440

 Score =  509 bits (1312), Expect = e-144
 Identities = 302/766 (39%), Positives = 431/766 (56%), Gaps = 67/766 (8%)

Query: 1187 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 1241
            P  FT+GD++ Y GF N  L   + Y ++F        E+K      AT   +     + 
Sbjct: 682  PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741

Query: 1242 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH- 1300
             DP   TD    +  +   +L  VFI+ +++ IL+ K+ +  +  RK ++ N ++  +H 
Sbjct: 742  PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKL-AKKRKDAMGNTRQEMTHM 798

Query: 1301 --------------HPTDPVEL----------RRLNFQTPGMAS---------------- 1320
                          H  DP+ +          R  N      +S                
Sbjct: 799  VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP 858

Query: 1321 ------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYA 1374
                  HP I + +L  HI  +K +D+  F +EYES   GQ  +W+ +  + N+ KNRY 
Sbjct: 859  YQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYG 918

Query: 1375 NVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQR 1434
            N+IAYDHSRV+L  +E  P SDY+NANYIDGY++ + YIATQG + ET  DFWRMIW+++
Sbjct: 919  NIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQ 978

Query: 1435 SATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSE 1494
            SA +VM+T L E  RVKC +YWP   TE +G  +VT ++   LA Y VRTF L + G +E
Sbjct: 979  SACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNE 1037

Query: 1495 KREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVID 1554
             REV+QF FT WPDHGVP H T  L+F+RRVK  NPP AGP+VVHCSAG GRTGC+IVID
Sbjct: 1038 IREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVID 1097

Query: 1555 AMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYA 1614
             ML+  + E  VDIY  V  +R++R  MVQTE+QYIFIHDA+LEA  CG T +P     A
Sbjct: 1098 IMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKA 1157

Query: 1615 YIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLVNIMPYESTR 1672
                + +I++  N + ++ EF+ L S   +        A LP N  KNR ++++P +   
Sbjct: 1158 AYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCL 1217

Query: 1673 VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK 1732
              L  I G E S+YINA+ +D YRQ  A+I TQ PL  T +DFWR+++++  T +VML +
Sbjct: 1218 PFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNE 1276

Query: 1733 LREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQSRTVRQ 1789
            +     + C QYWP E   RY    V+ M+   + ++   I R   +T  ++G    V+Q
Sbjct: 1277 VDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY-LMVQQ 1333

Query: 1790 FQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVFITLSIV 1847
            FQ+  W   + VP S   F+  I QV K +E+  + +G   +HC  G GR+G+F  + IV
Sbjct: 1334 FQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIV 1393

Query: 1848 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1893
            +E ++ + VVD+F  VK LR  +P MV+  +QY+F Y  ALEYL S
Sbjct: 1394 VEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 94/444 (21%), Positives = 174/444 (39%), Gaps = 58/444 (13%)

Query: 233 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 286
           E+  G +    C+A G    + K  L   +    +D+P+ +    +N  R +A+      
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260

Query: 287 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 335
                  Y CV  S  G  +   AQ+ V+  P+P   P +     T + +  ++ +    
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320

Query: 336 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 393
            P+    ++++  +    + E   V    Y +  L P ++YE RV+       G G P  
Sbjct: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378

Query: 394 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 451
           P++T+T    P   P+ ++   + +  I V W+          GY +   +T + T   +
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430

Query: 452 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 502
            +  HN + +             + +L P    S+K++  T+      S +  + T   V
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489

Query: 503 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 550
           PG  P+        E  I L+W  P   +  I  YE+ Y             G  Q ++ 
Sbjct: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549

Query: 551 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSS 610
           +   T +    L P + Y F + A + +G G +TA I+  T  S P+ P  +    S + 
Sbjct: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDYEGVDASLNE 608

Query: 611 TSILVSWQPPPVEKQNGIITEYSI 634
           T+  ++    P + +   I+ Y I
Sbjct: 609 TATTITVLLRPAQAKGAPISAYQI 632



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 86/385 (22%), Positives = 145/385 (37%), Gaps = 44/385 (11%)

Query: 556 SYRLQGLKPNSLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSIL 614
           S+RLQ +       +R   +S +G G S  A++  R    +P APPQ +       T +L
Sbjct: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE-PPRPIAPPQLLGV---GPTYLL 309

Query: 615 VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RI 672
           +      +     II +  ++Y    G   + H +     +   Y L  L+  TEY  R+
Sbjct: 310 IQLNANSIIGDGPIILK-EVEYRMTSGSWTETHAV-----NAPTYKLWHLDPDTEYEIRV 363

Query: 673 TVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIR 732
            +T   + G G     ++ RT    P   P+ +++  + +  + V W S   N       
Sbjct: 364 LLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTF 423

Query: 733 GYQV--HYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAY 790
              +  HY R  N E K   +  D              +H  +++ L P T+ SL +   
Sbjct: 424 NVTICYHYFRGHN-ESKADCLDMD----------PKAPQH--VVNHLPPYTNVSLKMILT 470

Query: 791 TTKGDGARSKPKLVSTTGAVPGK-PRLVINHTQM-NTALIQWHPPVDTFGPLQGYRLKFG 848
             +G    S+  ++ T   VPG  P   +  T   N   + W  P+D  G +  Y + + 
Sbjct: 471 NPEG-RKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYS 529

Query: 849 R-KDMEPLT-------TLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI 900
             +  +P         T+       H     +H G +Y F + A    GFG      ++ 
Sbjct: 530 SIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTT 589

Query: 901 PEEVPT-----GFPQNLHSEGTTST 920
               PT     G   +L+   TT T
Sbjct: 590 NISAPTLPDYEGVDASLNETATTIT 614



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 103/447 (23%), Positives = 166/447 (37%), Gaps = 59/447 (13%)

Query: 137 VERTRTATMLCAASGNPDPEIT-WFK-----DFLPVDTSNNNGRIKQLRSGALQIEQSEE 190
           V   + AT  C A+G        W +     D     T N N R     + + ++++  +
Sbjct: 206 VNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHR---RFAASFRLQEVTK 262

Query: 191 SDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGG---SVNITCVAV 247
           +DQ  Y CV  +  G+  S  A L VR    PPR   PP    + P      +N   +  
Sbjct: 263 TDQDLYRCVTQSERGSGVSNFAQLIVRE---PPRPIAPPQLLGVGPTYLLIQLNANSIIG 319

Query: 248 GSP--MPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMST--------LGV 297
             P  +  V++ + +   T  +   +     +L  +     Y    + T        L  
Sbjct: 320 DGPIILKEVEYRMTSGSWT--ETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPG 377

Query: 298 IEAIAQITVKALPKPPGTPVVTESTATSITLTWDS----------GNPEPVSYYIIQHKP 347
              I +       + P T  + E  A  I + W+S           N     +Y   H  
Sbjct: 378 PPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNE 437

Query: 348 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 407
             ++ L  ++D  A  ++ V  L PY++   +++  N  GR   SE  + QT E  P   
Sbjct: 438 SKADCL--DMDPKAP-QHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPV 493

Query: 408 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNN--WMKHNVADS 461
           P            I + WKEP +PNG I  Y + Y    + DP   V        N+ +S
Sbjct: 494 PVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNS 553

Query: 462 QITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP--------LNFKAEP 513
                 +L P  TY   + A T  G GP ++ I V T    P  P        LN   E 
Sbjct: 554 THHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDYEGVDASLN---ET 609

Query: 514 ESETSILLSWTPPRSDTIANYELVYKD 540
            +  ++LL     +   I+ Y++V ++
Sbjct: 610 ATTITVLLRPAQAKGAPISAYQIVVEE 636



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 58/235 (24%), Positives = 82/235 (34%), Gaps = 26/235 (11%)

Query: 777 LQPETSYSLTV--TAYTTKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWHP 832
           L P+T Y + V  T     G G    P +  T  A P +    L I   Q     + W  
Sbjct: 353 LDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES 412

Query: 833 ------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARN 886
                    TF     Y    G  + +    L+   K        +    +   ++   N
Sbjct: 413 LGYNITRCHTFNVTICYHYFRGHNESKA-DCLDMDPKAPQHVVNHLPPYTNVSLKMILTN 471

Query: 887 KVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR 946
             G  E     I   E+VP   P       +    + L+W+ P+  + NGIIT+Y + Y 
Sbjct: 472 PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYS 529

Query: 947 DINI--PLLPMEQLIVPADTTMTLTG--------LKPDTTYDVKVRAHTSKGPGP 991
            I    P +P+     P  T   L          L P TTY   +RA T KG GP
Sbjct: 530 SIRSFDPAVPVAG---PPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP 581


>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
            [Homo sapiens]
          Length = 1446

 Score =  503 bits (1295), Expect = e-142
 Identities = 302/772 (39%), Positives = 431/772 (55%), Gaps = 73/772 (9%)

Query: 1187 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 1241
            P  FT+GD++ Y GF N  L   + Y ++F        E+K      AT   +     + 
Sbjct: 682  PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741

Query: 1242 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSH- 1300
             DP   TD    +  +   +L  VFI+ +++ IL+ K+ +  +  RK ++ N ++  +H 
Sbjct: 742  PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKL-AKKRKDAMGNTRQEMTHM 798

Query: 1301 --------------HPTDPVEL----------RRLNFQTPGMAS---------------- 1320
                          H  DP+ +          R  N      +S                
Sbjct: 799  VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP 858

Query: 1321 ------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYA 1374
                  HP I + +L  HI  +K +D+  F +EYES   GQ  +W+ +  + N+ KNRY 
Sbjct: 859  YQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYG 918

Query: 1375 NVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSLPETFGDFWR 1428
            N+IAYDHSRV+L  +E  P SDY+NANYID      GY++ + YIATQG + ET  DFWR
Sbjct: 919  NIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWR 978

Query: 1429 MIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALY 1488
            MIW+++SA +VM+T L E  RVKC +YWP   TE +G  +VT ++   LA Y VRTF L 
Sbjct: 979  MIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLE 1037

Query: 1489 KNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1548
            + G +E REV+QF FT WPDHGVP H T  L+F+RRVK  NPP AGP+VVHCSAG GRTG
Sbjct: 1038 RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTG 1097

Query: 1549 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVP 1608
            C+IVID ML+  + E  VDIY  V  +R++R  MVQTE+QYIFIHDA+LEA  CG T +P
Sbjct: 1098 CYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIP 1157

Query: 1609 ARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLVNIM 1666
                 A    + +I++  N + ++ EF+ L S   +        A LP N  KNR ++++
Sbjct: 1158 VCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDML 1217

Query: 1667 PYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI 1726
            P +     L  I G E S+YINA+ +D YRQ  A+I TQ PL  T +DFWR+++++  T 
Sbjct: 1218 PPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTS 1276

Query: 1727 VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQ 1783
            +VML ++     + C QYWP E   RY    V+ M+   + ++   I R   +T  ++G 
Sbjct: 1277 IVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY 1334

Query: 1784 SRTVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVF 1841
               V+QFQ+  W   + VP S   F+  I QV K +E+  + +G   +HC  G GR+G+F
Sbjct: 1335 -LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMF 1393

Query: 1842 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1893
              + IV+E ++ + VVD+F  VK LR  +P MV+  +QY+F Y  ALEYL S
Sbjct: 1394 CAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 94/444 (21%), Positives = 174/444 (39%), Gaps = 58/444 (13%)

Query: 233 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 286
           E+  G +    C+A G    + K  L   +    +D+P+ +    +N  R +A+      
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260

Query: 287 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 335
                  Y CV  S  G  +   AQ+ V+  P+P   P +     T + +  ++ +    
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320

Query: 336 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 393
            P+    ++++  +    + E   V    Y +  L P ++YE RV+       G G P  
Sbjct: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378

Query: 394 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 451
           P++T+T    P   P+ ++   + +  I V W+          GY +   +T + T   +
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430

Query: 452 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 502
            +  HN + +             + +L P    S+K++  T+      S +  + T   V
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489

Query: 503 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 550
           PG  P+        E  I L+W  P   +  I  YE+ Y             G  Q ++ 
Sbjct: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549

Query: 551 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSS 610
           +   T +    L P + Y F + A + +G G +TA I+  T  S P+ P  +    S + 
Sbjct: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDYEGVDASLNE 608

Query: 611 TSILVSWQPPPVEKQNGIITEYSI 634
           T+  ++    P + +   I+ Y I
Sbjct: 609 TATTITVLLRPAQAKGAPISAYQI 632



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 86/385 (22%), Positives = 145/385 (37%), Gaps = 44/385 (11%)

Query: 556 SYRLQGLKPNSLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSIL 614
           S+RLQ +       +R   +S +G G S  A++  R    +P APPQ +       T +L
Sbjct: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE-PPRPIAPPQLLGV---GPTYLL 309

Query: 615 VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RI 672
           +      +     II +  ++Y    G   + H +     +   Y L  L+  TEY  R+
Sbjct: 310 IQLNANSIIGDGPIILK-EVEYRMTSGSWTETHAV-----NAPTYKLWHLDPDTEYEIRV 363

Query: 673 TVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIR 732
            +T   + G G     ++ RT    P   P+ +++  + +  + V W S   N       
Sbjct: 364 LLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTF 423

Query: 733 GYQV--HYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAY 790
              +  HY R  N E K   +  D              +H  +++ L P T+ SL +   
Sbjct: 424 NVTICYHYFRGHN-ESKADCLDMD----------PKAPQH--VVNHLPPYTNVSLKMILT 470

Query: 791 TTKGDGARSKPKLVSTTGAVPGK-PRLVINHTQM-NTALIQWHPPVDTFGPLQGYRLKFG 848
             +G    S+  ++ T   VPG  P   +  T   N   + W  P+D  G +  Y + + 
Sbjct: 471 NPEG-RKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYS 529

Query: 849 R-KDMEPLT-------TLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI 900
             +  +P         T+       H     +H G +Y F + A    GFG      ++ 
Sbjct: 530 SIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTT 589

Query: 901 PEEVPT-----GFPQNLHSEGTTST 920
               PT     G   +L+   TT T
Sbjct: 590 NISAPTLPDYEGVDASLNETATTIT 614



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 103/447 (23%), Positives = 166/447 (37%), Gaps = 59/447 (13%)

Query: 137 VERTRTATMLCAASGNPDPEIT-WFK-----DFLPVDTSNNNGRIKQLRSGALQIEQSEE 190
           V   + AT  C A+G        W +     D     T N N R     + + ++++  +
Sbjct: 206 VNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHR---RFAASFRLQEVTK 262

Query: 191 SDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGG---SVNITCVAV 247
           +DQ  Y CV  +  G+  S  A L VR    PPR   PP    + P      +N   +  
Sbjct: 263 TDQDLYRCVTQSERGSGVSNFAQLIVRE---PPRPIAPPQLLGVGPTYLLIQLNANSIIG 319

Query: 248 GSP--MPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMST--------LGV 297
             P  +  V++ + +   T  +   +     +L  +     Y    + T        L  
Sbjct: 320 DGPIILKEVEYRMTSGSWT--ETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPG 377

Query: 298 IEAIAQITVKALPKPPGTPVVTESTATSITLTWDS----------GNPEPVSYYIIQHKP 347
              I +       + P T  + E  A  I + W+S           N     +Y   H  
Sbjct: 378 PPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNE 437

Query: 348 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 407
             ++ L  ++D  A  ++ V  L PY++   +++  N  GR   SE  + QT E  P   
Sbjct: 438 SKADCL--DMDPKAP-QHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPV 493

Query: 408 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNN--WMKHNVADS 461
           P            I + WKEP +PNG I  Y + Y    + DP   V        N+ +S
Sbjct: 494 PVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNS 553

Query: 462 QITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP--------LNFKAEP 513
                 +L P  TY   + A T  G GP ++ I V T    P  P        LN   E 
Sbjct: 554 THHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDYEGVDASLN---ET 609

Query: 514 ESETSILLSWTPPRSDTIANYELVYKD 540
            +  ++LL     +   I+ Y++V ++
Sbjct: 610 ATTITVLLRPAQAKGAPISAYQIVVEE 636



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 58/235 (24%), Positives = 82/235 (34%), Gaps = 26/235 (11%)

Query: 777 LQPETSYSLTV--TAYTTKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWHP 832
           L P+T Y + V  T     G G    P +  T  A P +    L I   Q     + W  
Sbjct: 353 LDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES 412

Query: 833 ------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARN 886
                    TF     Y    G  + +    L+   K        +    +   ++   N
Sbjct: 413 LGYNITRCHTFNVTICYHYFRGHNESKA-DCLDMDPKAPQHVVNHLPPYTNVSLKMILTN 471

Query: 887 KVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR 946
             G  E     I   E+VP   P       +    + L+W+ P+  + NGIIT+Y + Y 
Sbjct: 472 PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYS 529

Query: 947 DINI--PLLPMEQLIVPADTTMTLTG--------LKPDTTYDVKVRAHTSKGPGP 991
            I    P +P+     P  T   L          L P TTY   +RA T KG GP
Sbjct: 530 SIRSFDPAVPVAG---PPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP 581


>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
            precursor [Homo sapiens]
          Length = 1452

 Score =  498 bits (1282), Expect = e-140
 Identities = 266/580 (45%), Positives = 357/580 (61%), Gaps = 12/580 (2%)

Query: 1321 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1380
            HP I + +L  HI ++K  +   F +EYES   GQ   W+ +  + N+ KNRY N+IAYD
Sbjct: 877  HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYD 936

Query: 1381 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1440
            HSRV L  IEG   SDY+N NYIDGY + N YIATQG + ET  DFWRM+W + +A+++M
Sbjct: 937  HSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 996

Query: 1441 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1500
            +T L E  RVKC +YWP   TE +  ++VTL++T  LA Y +RTFA+ K G  E RE+RQ
Sbjct: 997  VTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQ 1055

Query: 1501 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1560
            F FT WPDHGVP H T  L F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+  
Sbjct: 1056 FHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMA 1115

Query: 1561 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1620
            + E  VDIY  V  +R++R  MVQTE+QY+FIHDA+LEA  CG+T VPA  + +    + 
Sbjct: 1116 EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMN 1175

Query: 1621 QIETGENVTGMELEFKRL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1678
            +++   N + ++ EF+ L   +          A LP N  KNR ++I+P +     L  I
Sbjct: 1176 KLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI 1235

Query: 1679 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1738
             G E S+YINA+ +D Y+Q  A+I TQ PL  T +DFWR++ +++ T VVML  +     
Sbjct: 1236 DG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--A 1292

Query: 1739 EKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1795
            + C QYWP     R    Q   V    E ++   I R +     +DG  R V+QFQF  W
Sbjct: 1293 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGW 1351

Query: 1796 P-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1853
            P  +  P S   F+  I QV K +E++ G +G   VHC  G GR+G F  +SIV E +R+
Sbjct: 1352 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1411

Query: 1854 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1893
            +  VD+F  VK LR  +P MV   DQY+F Y  ALEYL S
Sbjct: 1412 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1451



 Score =  137 bits (344), Expect = 1e-31
 Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)

Query: 1367 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1426
            N  KNR  +++  D     L  I+G   S+Y+NA  +D Y++ +A+I TQ  LP T  DF
Sbjct: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271

Query: 1427 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1486
            WR++ +    +VVM+  ++      C QYWP  G   HG +QV  +          R F 
Sbjct: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329

Query: 1487 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1540
            +Y     +   R V+QFQF  WP +   P     FL  +R+V           G  VVHC
Sbjct: 1330 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1389

Query: 1541 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1600
              G GR+G F  I  + E ++H++TVD++  V  +R  +  MV   DQY F ++  LE +
Sbjct: 1390 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1449

Query: 1601 TCG 1603
              G
Sbjct: 1450 NSG 1452



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 77/349 (22%), Positives = 127/349 (36%), Gaps = 31/349 (8%)

Query: 570 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 629
           +R   R+  G+G S            P APPQ     S  +T + +      +     I+
Sbjct: 258 YRCMIRTEGGVGISNYAELVVKEPPVPIAPPQ---LASVGATYLWIQLNANSINGDGPIV 314

Query: 630 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPESL 687
                  TA    +D+       P D+T Y +  L+  TEY I+V  T   + G G    
Sbjct: 315 AREVEYCTASGSWNDRQ------PVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGP 368

Query: 688 SVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPK 747
           ++  RT    P   PRK+EV  V S  + + W     N          VHY     G+ +
Sbjct: 369 ALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQ 428

Query: 748 GQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 807
                   +  +  W+ +++     I + L P T+ S+ +     +G    S+  +V T 
Sbjct: 429 --------VREEVSWDTENSHPQHTI-TNLSPYTNVSVKLILMNPEGR-KESQELIVQTD 478

Query: 808 GAVPGK--PRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGR-KDMEPLTTLEFSE-- 862
             +PG      +   T      +QW  P  T+G +  Y + +      +P   L      
Sbjct: 479 EDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGR 538

Query: 863 -----KEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 906
                 E HF    ++ G +Y F + A    GFG     + +     P+
Sbjct: 539 VSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPS 587



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 102/438 (23%), Positives = 167/438 (38%), Gaps = 41/438 (9%)

Query: 231 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 281
           N E+  G      C A+G  +   +  L   D+   P  ++ +    R +   N V    
Sbjct: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252

Query: 282 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 337
           R +  Y C+  +  GV I   A++ VK  P P   P +    AT   I L  +S N + P
Sbjct: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312

Query: 338 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 395
           +    +++   +    + +   V +T Y +  L P ++YE  V+       G G P   +
Sbjct: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370

Query: 396 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 451
            T+T    P   PR ++   + S  I ++W+       +   Y +     Y +   + V 
Sbjct: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430

Query: 452 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 509
             +  +  +S    TI NL P    SVK++     G    S ++ V T   +PG  P   
Sbjct: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489

Query: 510 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 556
                 E  I L W  P      I  YE+ YK             + G   ++  E  T 
Sbjct: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547

Query: 557 YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 616
           +   GL P + Y F + A + +G G   A     T  S PS P  ++  T  + T   V+
Sbjct: 548 FLFFGLYPGTTYSFTIRASTAKGFG-PPATNQFTTKISAPSMPAYELE-TPLNQTDNTVT 605

Query: 617 WQPPPVEKQNGIITEYSI 634
               P   +   ++ Y I
Sbjct: 606 VMLKPAHSRGAPVSVYQI 623



 Score = 65.1 bits (157), Expect = 6e-10
 Identities = 65/287 (22%), Positives = 119/287 (41%), Gaps = 47/287 (16%)

Query: 318 VTESTATSITLTWDSGNPEPVSYYIIQHKPKN-----------SEELYKEIDGVATT--- 363
           V E  +  IT+ W     EP  Y + +    N            E++ +E+         
Sbjct: 388 VVEVKSRQITIRW-----EPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHP 442

Query: 364 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 423
           ++++  LSPY++   +++ +N  GR   S+ ++ QT E  P + P +          I +
Sbjct: 443 QHTITNLSPYTNVSVKLILMNPEGR-KESQELIVQTDEDLPGAVPTESIQGSTFEEKIFL 501

Query: 424 QWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMKHNVADSQITTIGN--------LVP 471
           QW+EP +  G I  Y + Y    + DP   ++N         +++ +GN        L P
Sbjct: 502 QWREPTQTYGVITLYEITYKAVSSFDPEIDLSN------QSGRVSKLGNETHFLFFGLYP 555

Query: 472 QKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESET----SILLSWTPPR 527
             TYS  + A T+ G GP +++ Q  T+   P  P      P ++T    +++L     R
Sbjct: 556 GTTYSFTIRASTAKGFGPPATN-QFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614

Query: 528 SDTIANYELVYKDGEHGEEQRIT----IEPGTSYRLQGLKPNSLYYF 570
              ++ Y++V ++      ++ T      P   +       NS YYF
Sbjct: 615 GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYF 661



 Score = 58.5 bits (140), Expect = 6e-08
 Identities = 78/351 (22%), Positives = 129/351 (36%), Gaps = 45/351 (12%)

Query: 669  EYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQH 728
            +YR  +   T+ G G  + + L+     VP  PP   ++ +V +T + +   +   N   
Sbjct: 257  KYRCMI--RTEGGVGISNYAELVVKEPPVPIAPP---QLASVGATYLWIQLNANSINGD- 310

Query: 729  GQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVT 788
            G I   +V Y          QP+              D+T +   I  L P+T Y ++V 
Sbjct: 311  GPIVAREVEYCTASGSWNDRQPV--------------DSTSYK--IGHLDPDTEYEISVL 354

Query: 789  AYTTKGDGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGY 843
              T  G+G    P     T       + G  +L +   +     I+W P          Y
Sbjct: 355  L-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSY 413

Query: 844  RLKF-------GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVK 896
             L         G++ +    + +        T T++    +   +L   N  G  E    
Sbjct: 414  NLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQEL 473

Query: 897  EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-----DINIP 951
             +   E++P   P       T    + L W+ P   +  G+IT Y + Y+     D  I 
Sbjct: 474  IVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEID 531

Query: 952  LLPMEQLI--VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1000
            L      +  +  +T     GL P TTY   +RA T+KG GP + + QF T
Sbjct: 532  LSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 78/366 (21%), Positives = 139/366 (37%), Gaps = 64/366 (17%)

Query: 967  TLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVMKT 1019
            T+T L P T   VK+     +G    S  +  +T       +P + +    F  K     
Sbjct: 445  TITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTESIQGSTFEEK----- 498

Query: 1020 SVLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEK 1066
             + L W  P + Y     ++I Y      + E+D           G  T  L   L P  
Sbjct: 499  -IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGT 557

Query: 1067 SYSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVP 1119
            +YSF +   T +G          T  +AP +    PA+  +T L   D  +TV L P   
Sbjct: 558  TYSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHS 613

Query: 1120 ANENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVEL 1175
                +  Y I++   +  R K     +K +  P   +   LL                  
Sbjct: 614  RGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS---------------- 657

Query: 1176 KPYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYAT 1230
            + Y AA F     +    FT+GD+K Y G+ N  L   + Y ++F  A   + E+K+   
Sbjct: 658  QYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCV 717

Query: 1231 SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSS 1290
               +    +    P+P   + +  + + G +  ++  + I + ++L  +KR  +  RK +
Sbjct: 718  QVATKGAATPKPVPEP-EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKET 776

Query: 1291 IPNNKE 1296
            + + ++
Sbjct: 777  MSSTRQ 782


>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
            precursor [Homo sapiens]
          Length = 1465

 Score =  498 bits (1282), Expect = e-140
 Identities = 266/580 (45%), Positives = 357/580 (61%), Gaps = 12/580 (2%)

Query: 1321 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1380
            HP I + +L  HI ++K  +   F +EYES   GQ   W+ +  + N+ KNRY N+IAYD
Sbjct: 890  HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYD 949

Query: 1381 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1440
            HSRV L  IEG   SDY+N NYIDGY + N YIATQG + ET  DFWRM+W + +A+++M
Sbjct: 950  HSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 1009

Query: 1441 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1500
            +T L E  RVKC +YWP   TE +  ++VTL++T  LA Y +RTFA+ K G  E RE+RQ
Sbjct: 1010 VTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQ 1068

Query: 1501 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1560
            F FT WPDHGVP H T  L F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+  
Sbjct: 1069 FHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMA 1128

Query: 1561 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1620
            + E  VDIY  V  +R++R  MVQTE+QY+FIHDA+LEA  CG+T VPA  + +    + 
Sbjct: 1129 EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMN 1188

Query: 1621 QIETGENVTGMELEFKRL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1678
            +++   N + ++ EF+ L   +          A LP N  KNR ++I+P +     L  I
Sbjct: 1189 KLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI 1248

Query: 1679 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1738
             G E S+YINA+ +D Y+Q  A+I TQ PL  T +DFWR++ +++ T VVML  +     
Sbjct: 1249 DG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--A 1305

Query: 1739 EKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1795
            + C QYWP     R    Q   V    E ++   I R +     +DG  R V+QFQF  W
Sbjct: 1306 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGW 1364

Query: 1796 P-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1853
            P  +  P S   F+  I QV K +E++ G +G   VHC  G GR+G F  +SIV E +R+
Sbjct: 1365 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1424

Query: 1854 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1893
            +  VD+F  VK LR  +P MV   DQY+F Y  ALEYL S
Sbjct: 1425 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464



 Score =  137 bits (344), Expect = 1e-31
 Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)

Query: 1367 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1426
            N  KNR  +++  D     L  I+G   S+Y+NA  +D Y++ +A+I TQ  LP T  DF
Sbjct: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284

Query: 1427 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1486
            WR++ +    +VVM+  ++      C QYWP  G   HG +QV  +          R F 
Sbjct: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342

Query: 1487 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1540
            +Y     +   R V+QFQF  WP +   P     FL  +R+V           G  VVHC
Sbjct: 1343 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1402

Query: 1541 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1600
              G GR+G F  I  + E ++H++TVD++  V  +R  +  MV   DQY F ++  LE +
Sbjct: 1403 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1462

Query: 1601 TCG 1603
              G
Sbjct: 1463 NSG 1465



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 77/349 (22%), Positives = 127/349 (36%), Gaps = 31/349 (8%)

Query: 570 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 629
           +R   R+  G+G S            P APPQ     S  +T + +      +     I+
Sbjct: 258 YRCMIRTEGGVGISNYAELVVKEPPVPIAPPQ---LASVGATYLWIQLNANSINGDGPIV 314

Query: 630 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPESL 687
                  TA    +D+       P D+T Y +  L+  TEY I+V  T   + G G    
Sbjct: 315 AREVEYCTASGSWNDRQ------PVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGP 368

Query: 688 SVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPK 747
           ++  RT    P   PRK+EV  V S  + + W     N          VHY     G+ +
Sbjct: 369 ALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQ 428

Query: 748 GQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 807
                   +  +  W+ +++     I + L P T+ S+ +     +G    S+  +V T 
Sbjct: 429 --------VREEVSWDTENSHPQHTI-TNLSPYTNVSVKLILMNPEGR-KESQELIVQTD 478

Query: 808 GAVPGK--PRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGR-KDMEPLTTLEFSE-- 862
             +PG      +   T      +QW  P  T+G +  Y + +      +P   L      
Sbjct: 479 EDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGR 538

Query: 863 -----KEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 906
                 E HF    ++ G +Y F + A    GFG     + +     P+
Sbjct: 539 VSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPS 587



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 102/438 (23%), Positives = 167/438 (38%), Gaps = 41/438 (9%)

Query: 231 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 281
           N E+  G      C A+G  +   +  L   D+   P  ++ +    R +   N V    
Sbjct: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252

Query: 282 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 337
           R +  Y C+  +  GV I   A++ VK  P P   P +    AT   I L  +S N + P
Sbjct: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312

Query: 338 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 395
           +    +++   +    + +   V +T Y +  L P ++YE  V+       G G P   +
Sbjct: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370

Query: 396 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 451
            T+T    P   PR ++   + S  I ++W+       +   Y +     Y +   + V 
Sbjct: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430

Query: 452 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 509
             +  +  +S    TI NL P    SVK++     G    S ++ V T   +PG  P   
Sbjct: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489

Query: 510 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 556
                 E  I L W  P      I  YE+ YK             + G   ++  E  T 
Sbjct: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547

Query: 557 YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 616
           +   GL P + Y F + A + +G G   A     T  S PS P  ++  T  + T   V+
Sbjct: 548 FLFFGLYPGTTYSFTIRASTAKGFG-PPATNQFTTKISAPSMPAYELE-TPLNQTDNTVT 605

Query: 617 WQPPPVEKQNGIITEYSI 634
               P   +   ++ Y I
Sbjct: 606 VMLKPAHSRGAPVSVYQI 623



 Score = 65.1 bits (157), Expect = 6e-10
 Identities = 65/287 (22%), Positives = 119/287 (41%), Gaps = 47/287 (16%)

Query: 318 VTESTATSITLTWDSGNPEPVSYYIIQHKPKN-----------SEELYKEIDGVATT--- 363
           V E  +  IT+ W     EP  Y + +    N            E++ +E+         
Sbjct: 388 VVEVKSRQITIRW-----EPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHP 442

Query: 364 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 423
           ++++  LSPY++   +++ +N  GR   S+ ++ QT E  P + P +          I +
Sbjct: 443 QHTITNLSPYTNVSVKLILMNPEGR-KESQELIVQTDEDLPGAVPTESIQGSTFEEKIFL 501

Query: 424 QWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMKHNVADSQITTIGN--------LVP 471
           QW+EP +  G I  Y + Y    + DP   ++N         +++ +GN        L P
Sbjct: 502 QWREPTQTYGVITLYEITYKAVSSFDPEIDLSN------QSGRVSKLGNETHFLFFGLYP 555

Query: 472 QKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESET----SILLSWTPPR 527
             TYS  + A T+ G GP +++ Q  T+   P  P      P ++T    +++L     R
Sbjct: 556 GTTYSFTIRASTAKGFGPPATN-QFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614

Query: 528 SDTIANYELVYKDGEHGEEQRIT----IEPGTSYRLQGLKPNSLYYF 570
              ++ Y++V ++      ++ T      P   +       NS YYF
Sbjct: 615 GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYF 661



 Score = 58.5 bits (140), Expect = 6e-08
 Identities = 78/351 (22%), Positives = 129/351 (36%), Gaps = 45/351 (12%)

Query: 669  EYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQH 728
            +YR  +   T+ G G  + + L+     VP  PP   ++ +V +T + +   +   N   
Sbjct: 257  KYRCMI--RTEGGVGISNYAELVVKEPPVPIAPP---QLASVGATYLWIQLNANSINGD- 310

Query: 729  GQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVT 788
            G I   +V Y          QP+              D+T +   I  L P+T Y ++V 
Sbjct: 311  GPIVAREVEYCTASGSWNDRQPV--------------DSTSYK--IGHLDPDTEYEISVL 354

Query: 789  AYTTKGDGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGY 843
              T  G+G    P     T       + G  +L +   +     I+W P          Y
Sbjct: 355  L-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSY 413

Query: 844  RLKF-------GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVK 896
             L         G++ +    + +        T T++    +   +L   N  G  E    
Sbjct: 414  NLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQEL 473

Query: 897  EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-----DINIP 951
             +   E++P   P       T    + L W+ P   +  G+IT Y + Y+     D  I 
Sbjct: 474  IVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEID 531

Query: 952  LLPMEQLI--VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1000
            L      +  +  +T     GL P TTY   +RA T+KG GP + + QF T
Sbjct: 532  LSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 78/366 (21%), Positives = 139/366 (37%), Gaps = 64/366 (17%)

Query: 967  TLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVMKT 1019
            T+T L P T   VK+     +G    S  +  +T       +P + +    F  K     
Sbjct: 445  TITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTESIQGSTFEEK----- 498

Query: 1020 SVLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEK 1066
             + L W  P + Y     ++I Y      + E+D           G  T  L   L P  
Sbjct: 499  -IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGT 557

Query: 1067 SYSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVP 1119
            +YSF +   T +G          T  +AP +    PA+  +T L   D  +TV L P   
Sbjct: 558  TYSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHS 613

Query: 1120 ANENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVEL 1175
                +  Y I++   +  R K     +K +  P   +   LL                  
Sbjct: 614  RGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS---------------- 657

Query: 1176 KPYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYAT 1230
            + Y AA F     +    FT+GD+K Y G+ N  L   + Y ++F  A   + E+K+   
Sbjct: 658  QYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCV 717

Query: 1231 SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSS 1290
               +    +    P+P   + +  + + G +  ++  + I + ++L  +KR  +  RK +
Sbjct: 718  QVATKGAATPKPVPEP-EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKET 776

Query: 1291 IPNNKE 1296
            + + ++
Sbjct: 777  MSSTRQ 782


>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
            precursor [Homo sapiens]
          Length = 1441

 Score =  495 bits (1275), Expect = e-139
 Identities = 354/1096 (32%), Positives = 535/1096 (48%), Gaps = 146/1096 (13%)

Query: 905  PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT 964
            P   PQN+      +  + L W+P   A         T+ Y+ +        + ++   +
Sbjct: 386  PVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSS 445

Query: 965  TMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVM 1017
              TL GL+P  T  +++     +G    S  +  +T       +P++ +    F  K   
Sbjct: 446  HYTLRGLRPFMTIRLRLLLSNPEGRME-SEELVVQTEEDVPGAVPLESIQGGPFEEK--- 501

Query: 1018 KTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA---------------TQKLIVN 1061
               + + W+ P   N  +  ++I Y   K V  +D  A               T  L V 
Sbjct: 502  ---IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADLSSQRGKVFKLRNETHHLFVG 555

Query: 1062 LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPAFIGKTNL---DGMITVQLPE 1117
            L P  +YSF +  + ++A G    VT + A  +   + P +   T L   D  ITV L  
Sbjct: 556  LYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKP 613

Query: 1118 VPANENIKGYYIIIVP---LKKSRGK------FIKPWESPDEMELDELLKEISRKRRSIR 1168
              +       Y ++V    L+KSR        F  P    +   LD L            
Sbjct: 614  AQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSL------------ 661

Query: 1169 YGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKM 1227
            +    ELKP   A+  V    FT+GD+K Y G+ N  L   + Y ++F      + E+K+
Sbjct: 662  HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKI 717

Query: 1228 YAT---SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKR--- 1281
                  +  +    S  ++P+   D    +  V+  +L  +FII ++  +L  KR+R   
Sbjct: 718  NCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLL--MFIIILLGVMLTIKRRRNAY 775

Query: 1282 ----------------------------AESDSRKSSIPNNKE----------------- 1296
                                        A+  + K S   N E                 
Sbjct: 776  SYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSR 835

Query: 1297 ---------IPSH--HPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFS 1345
                     I +H     DPVE+       P     P I + +L  HI ++K      F 
Sbjct: 836  GELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIRVADLLQHITQMKRGQGYGFK 890

Query: 1346 QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDG 1405
            +EYE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV L  ++G P SDY+NANYIDG
Sbjct: 891  EEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDG 950

Query: 1406 YRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHG 1465
            Y +   YIATQG + ET  DFWRMIW++ SA++VM+T L E  RVKC +YWP   TE +G
Sbjct: 951  YHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYG 1009

Query: 1466 LVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRV 1525
             ++VTL++T  LA Y +RTF + K G  E RE+R F FT+WPDHGVP + T  L F+R+V
Sbjct: 1010 DIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQV 1069

Query: 1526 KTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQT 1585
            K  NPP+AGP+VVHCSAG GRTGCFI ID ML+  ++E  VDI+  V  +RAQR  +VQT
Sbjct: 1070 KFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQT 1129

Query: 1586 EDQYIFIHDALLEAVTCGNTEVPA---RNLYAYIQKLTQIETGENVTGMELEFKRLASSK 1642
            E+QY+F+HDA+LEA  CGNT +P    R+LY  I +L   +T  +    E +   + + +
Sbjct: 1130 EEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDP-QTNSSQIKDEFQTLNIVTPR 1188

Query: 1643 AHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYI 1702
                      LP N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++
Sbjct: 1189 VRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFV 1247

Query: 1703 ATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA 1762
             TQ PL  T  DFWR+++++N + VVML ++     + C QYWP + S  Y    V+ ++
Sbjct: 1248 VTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVS 1305

Query: 1763 EYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKE 1819
                   I R F++ +    Q   R V+  Q+  WP  +  P S    +  + ++ K +E
Sbjct: 1306 ADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQE 1365

Query: 1820 QF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED 1878
            Q+ G++G   VHC  G GR+G F  +  V E ++ + ++D+F  VK LR  +  MV+T +
Sbjct: 1366 QYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLE 1425

Query: 1879 QYQFSYRAALEYLGSF 1894
            QY+F Y  ALEYL SF
Sbjct: 1426 QYKFVYEVALEYLSSF 1441



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 93/378 (24%), Positives = 152/378 (40%), Gaps = 36/378 (9%)

Query: 282 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 338
           R  + Y CV  S  G  +   A++ VK  P P   P   E  A   T  W   N   +  
Sbjct: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316

Query: 339 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 394
                + + + + +   + E   V +  Y +  L P  +YE RV+       G GPP  P
Sbjct: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376

Query: 395 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 453
           + T+T    P   P++V+   + +  + +QW    EP G  +     Y      Q+V N 
Sbjct: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432

Query: 454 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 507
            ++     +  S   T+  L P  T  +++L   S  +G + S+  V+ T+  VPG  PL
Sbjct: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490

Query: 508 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 560
                   E  I + W PP   +  I  YE+ YK  G       ++ + G  ++L+    
Sbjct: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550

Query: 561 ----GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 616
               GL P + Y F + A + +G G       A T  S PS P  D   T  + T   ++
Sbjct: 551 HLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIA-TKISAPSMPEYDTD-TPLNETDTTIT 608

Query: 617 WQPPPVEKQNGIITEYSI 634
               P + +   ++ Y +
Sbjct: 609 VMLKPAQSRGAPVSVYQL 626



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 83/353 (23%), Positives = 137/353 (38%), Gaps = 30/353 (8%)

Query: 366 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 425
           SVA  +  S  ++R V  ++ G G  +   L       P + P       L +      W
Sbjct: 253 SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306

Query: 426 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 483
            +P   +    G  +   ++       W + ++ DS    + +L P   Y ++VL     
Sbjct: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366

Query: 484 SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 534
             G GP    +   T+   P   P N +        + L W P           +    Y
Sbjct: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426

Query: 535 ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 594
           + V+   ++  E+   I+  + Y L+GL+P      RL   +P+G   S  E+  +T + 
Sbjct: 427 QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE-ELVVQTEED 483

Query: 595 KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGED------DKPHE 648
            P A P +     P    I + W+PP   + NG+IT Y I Y AV   D       +  +
Sbjct: 484 VPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLDPSADLSSQRGK 541

Query: 649 ILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 701
           +  + ++ T +L   L   T Y  T+ A T  G GP  ++  I T    PS P
Sbjct: 542 VFKLRNE-THHLFVGLYPGTTYSFTIKASTAKGFGP-PVTTRIATKISAPSMP 592



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 82/346 (23%), Positives = 126/346 (36%), Gaps = 54/346 (15%)

Query: 668 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 727
           ++YR  +   +D G G  + + LI      P  PP   E+ AV +T +   W  P  N  
Sbjct: 263 SKYRCVI--RSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL---WIKPNANSI 314

Query: 728 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI---ISGLQPETSYS 784
            G                  G  +LK+V        + +T   D     +  L P+  Y 
Sbjct: 315 IGD-----------------GPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYE 357

Query: 785 LTVTAYTTKGDGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHP------P 833
           + V   T  G+G    P    TT       V G   + I   +     +QW P       
Sbjct: 358 IRVLL-TRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTR 416

Query: 834 VDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEE 893
             ++     Y+  F ++  E    ++ S    H+T   +    +   RL   N  G  E 
Sbjct: 417 CHSYNLTVQYQYVFNQQQYEAEEVIQTSS---HYTLRGLRPFMTIRLRLLLSNPEGRMES 473

Query: 894 MVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLL 953
               +   E+VP   P      G     + + W+PP   E NG+IT Y + Y+ +   L 
Sbjct: 474 EELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVG-SLD 530

Query: 954 PMEQLI--------VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 991
           P   L         +  +T     GL P TTY   ++A T+KG GP
Sbjct: 531 PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGP 576



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 91/409 (22%), Positives = 154/409 (37%), Gaps = 66/409 (16%)

Query: 566 SLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTS------PSSTSILVSWQ 618
           S+  +R   RS  G G S  AE+  +   + P APP+ ++  +      P++ SI+    
Sbjct: 261 SVSKYRCVIRSDGGSGVSNYAELIVKEPPT-PIAPPELLAVGATYLWIKPNANSII---- 315

Query: 619 PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RITVTA 676
                  +G I    ++Y    G   + H +     D+  Y L  L+   EY  R+ +T 
Sbjct: 316 ------GDGPIILKEVEYRTTTGTWAETHIV-----DSPNYKLWHLDPDVEYEIRVLLTR 364

Query: 677 HTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 736
             + G GP    +  RT    P   P+ VE+  + +  + + W             GY V
Sbjct: 365 PGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEP----------FGYAV 414

Query: 737 HYVRMENGEPKGQPMLKDVMLADAQWEFDDT--TEHDMIISGLQPETSYSLTVTAYTTKG 794
                 N   + Q +         Q+E ++   T     + GL+P  +  L +     +G
Sbjct: 415 TRCHSYNLTVQYQYVFNQ-----QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEG 469

Query: 795 DGARSKPKLVSTTGAVPGKPRL--VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRK-D 851
               S+  +V T   VPG   L  +          IQW PP +T G +  Y + +     
Sbjct: 470 R-MESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGS 528

Query: 852 MEPLTTLEFSE-------KEDHFTATDIHKGASYVFRLSARNKVGFG----EEMVKEISI 900
           ++P   L            E H     ++ G +Y F + A    GFG      +  +IS 
Sbjct: 529 LDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISA 588

Query: 901 PE--EVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 947
           P   E  T  P N      T T++ +  +P     R   ++ Y L+ ++
Sbjct: 589 PSMPEYDTDTPLN-----ETDTTITVMLKP--AQSRGAPVSVYQLVVKE 630


>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
            precursor [Homo sapiens]
          Length = 1460

 Score =  490 bits (1261), Expect = e-138
 Identities = 356/1115 (31%), Positives = 536/1115 (48%), Gaps = 165/1115 (14%)

Query: 905  PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT 964
            P   PQN+      +  + L W+P   A         T+ Y+ +        + ++   +
Sbjct: 386  PVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSS 445

Query: 965  TMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVM 1017
              TL GL+P  T  +++     +G    S  +  +T       +P++ +    F  K   
Sbjct: 446  HYTLRGLRPFMTIRLRLLLSNPEGRME-SEELVVQTEEDVPGAVPLESIQGGPFEEK--- 501

Query: 1018 KTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA---------------TQKLIVN 1061
               + + W+ P   N  +  ++I Y   K V  +D  A               T  L V 
Sbjct: 502  ---IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADLSSQRGKVFKLRNETHHLFVG 555

Query: 1062 LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPAFIGKTNL---DGMITVQLPE 1117
            L P  +YSF +  + ++A G    VT + A  +   + P +   T L   D  ITV L  
Sbjct: 556  LYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKP 613

Query: 1118 VPANENIKGYYIIIVP---LKKSRGK------FIKPWESPDEMELDELLKEISRKRRSIR 1168
              +       Y ++V    L+KSR        F  P    +   LD L            
Sbjct: 614  AQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSL------------ 661

Query: 1169 YGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKM 1227
            +    ELKP   A+  V    FT+GD+K Y G+ N  L   + Y ++F      + E+K+
Sbjct: 662  HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKI 717

Query: 1228 YAT-----SPYSDPVV-----------------SMDLDPQPITDEEEGLIWVVGPVLAVV 1265
                    +P     V                 S  ++P+   D    +  V+  +L  +
Sbjct: 718  NCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLL--M 775

Query: 1266 FIICIVIAILLYKRKR-------------------------------AESDSRKSSIPNN 1294
            FII ++  +L  KR+R                               A+  + K S   N
Sbjct: 776  FIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRN 835

Query: 1295 KE--------------------------IPSH--HPTDPVELRRLNFQTPGMASHPPIPI 1326
             E                          I +H     DPVE+       P     P I +
Sbjct: 836  DEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIRV 890

Query: 1327 LELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLL 1386
             +L  HI ++K      F +EYE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV L
Sbjct: 891  ADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRL 950

Query: 1387 SAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEE 1446
              ++G P SDY+NANYIDGY +   YIATQG + ET  DFWRMIW++ SA++VM+T L E
Sbjct: 951  LVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVE 1010

Query: 1447 RSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAW 1506
              RVKC +YWP   TE +G ++VTL++T  LA Y +RTF + K G  E RE+R F FT+W
Sbjct: 1011 VGRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSW 1069

Query: 1507 PDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTV 1566
            PDHGVP + T  L F+R+VK  NPP+AGP+VVHCSAG GRTGCFI ID ML+  ++E  V
Sbjct: 1070 PDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVV 1129

Query: 1567 DIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA---RNLYAYIQKLTQIE 1623
            DI+  V  +RAQR  +VQTE+QY+F+HDA+LEA  CGNT +P    R+LY  I +L   +
Sbjct: 1130 DIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDP-Q 1188

Query: 1624 TGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG 1683
            T  +    E +   + + +          LP N  KNR ++++P +     L  + G E 
Sbjct: 1189 TNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ES 1247

Query: 1684 SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQ 1743
            S+YINA+ +D ++Q  A++ TQ PL  T  DFWR+++++N + VVML ++     + C Q
Sbjct: 1248 SNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQ 1305

Query: 1744 YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGV 1800
            YWP + S  Y    V+ ++       I R F++ +    Q   R V+  Q+  WP  +  
Sbjct: 1306 YWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDT 1365

Query: 1801 PKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDI 1859
            P S    +  + ++ K +EQ+ G++G   VHC  G GR+G F  +  V E ++ + ++D+
Sbjct: 1366 PPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDV 1425

Query: 1860 FQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF 1894
            F  VK LR  +  MV+T +QY+F Y  ALEYL SF
Sbjct: 1426 FHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1460



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 93/378 (24%), Positives = 152/378 (40%), Gaps = 36/378 (9%)

Query: 282 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 338
           R  + Y CV  S  G  +   A++ VK  P P   P   E  A   T  W   N   +  
Sbjct: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316

Query: 339 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 394
                + + + + +   + E   V +  Y +  L P  +YE RV+       G GPP  P
Sbjct: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376

Query: 395 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 453
           + T+T    P   P++V+   + +  + +QW    EP G  +     Y      Q+V N 
Sbjct: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432

Query: 454 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 507
            ++     +  S   T+  L P  T  +++L   S  +G + S+  V+ T+  VPG  PL
Sbjct: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490

Query: 508 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 560
                   E  I + W PP   +  I  YE+ YK  G       ++ + G  ++L+    
Sbjct: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550

Query: 561 ----GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 616
               GL P + Y F + A + +G G       A T  S PS P  D   T  + T   ++
Sbjct: 551 HLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIA-TKISAPSMPEYDTD-TPLNETDTTIT 608

Query: 617 WQPPPVEKQNGIITEYSI 634
               P + +   ++ Y +
Sbjct: 609 VMLKPAQSRGAPVSVYQL 626



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 83/353 (23%), Positives = 137/353 (38%), Gaps = 30/353 (8%)

Query: 366 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 425
           SVA  +  S  ++R V  ++ G G  +   L       P + P       L +      W
Sbjct: 253 SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306

Query: 426 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 483
            +P   +    G  +   ++       W + ++ DS    + +L P   Y ++VL     
Sbjct: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366

Query: 484 SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 534
             G GP    +   T+   P   P N +        + L W P           +    Y
Sbjct: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426

Query: 535 ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 594
           + V+   ++  E+   I+  + Y L+GL+P      RL   +P+G   S  E+  +T + 
Sbjct: 427 QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE-ELVVQTEED 483

Query: 595 KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGED------DKPHE 648
            P A P +     P    I + W+PP   + NG+IT Y I Y AV   D       +  +
Sbjct: 484 VPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLDPSADLSSQRGK 541

Query: 649 ILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 701
           +  + ++ T +L   L   T Y  T+ A T  G GP  ++  I T    PS P
Sbjct: 542 VFKLRNE-THHLFVGLYPGTTYSFTIKASTAKGFGP-PVTTRIATKISAPSMP 592



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 82/346 (23%), Positives = 126/346 (36%), Gaps = 54/346 (15%)

Query: 668 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 727
           ++YR  +   +D G G  + + LI      P  PP   E+ AV +T +   W  P  N  
Sbjct: 263 SKYRCVI--RSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL---WIKPNANSI 314

Query: 728 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI---ISGLQPETSYS 784
            G                  G  +LK+V        + +T   D     +  L P+  Y 
Sbjct: 315 IGD-----------------GPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYE 357

Query: 785 LTVTAYTTKGDGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHP------P 833
           + V   T  G+G    P    TT       V G   + I   +     +QW P       
Sbjct: 358 IRVLL-TRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTR 416

Query: 834 VDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEE 893
             ++     Y+  F ++  E    ++ S    H+T   +    +   RL   N  G  E 
Sbjct: 417 CHSYNLTVQYQYVFNQQQYEAEEVIQTSS---HYTLRGLRPFMTIRLRLLLSNPEGRMES 473

Query: 894 MVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLL 953
               +   E+VP   P      G     + + W+PP   E NG+IT Y + Y+ +   L 
Sbjct: 474 EELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVG-SLD 530

Query: 954 PMEQLI--------VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 991
           P   L         +  +T     GL P TTY   ++A T+KG GP
Sbjct: 531 PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGP 576



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 91/409 (22%), Positives = 154/409 (37%), Gaps = 66/409 (16%)

Query: 566 SLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTS------PSSTSILVSWQ 618
           S+  +R   RS  G G S  AE+  +   + P APP+ ++  +      P++ SI+    
Sbjct: 261 SVSKYRCVIRSDGGSGVSNYAELIVKEPPT-PIAPPELLAVGATYLWIKPNANSII---- 315

Query: 619 PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RITVTA 676
                  +G I    ++Y    G   + H +     D+  Y L  L+   EY  R+ +T 
Sbjct: 316 ------GDGPIILKEVEYRTTTGTWAETHIV-----DSPNYKLWHLDPDVEYEIRVLLTR 364

Query: 677 HTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 736
             + G GP    +  RT    P   P+ VE+  + +  + + W             GY V
Sbjct: 365 PGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEP----------FGYAV 414

Query: 737 HYVRMENGEPKGQPMLKDVMLADAQWEFDDT--TEHDMIISGLQPETSYSLTVTAYTTKG 794
                 N   + Q +         Q+E ++   T     + GL+P  +  L +     +G
Sbjct: 415 TRCHSYNLTVQYQYVFNQ-----QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEG 469

Query: 795 DGARSKPKLVSTTGAVPGKPRL--VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRK-D 851
               S+  +V T   VPG   L  +          IQW PP +T G +  Y + +     
Sbjct: 470 R-MESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGS 528

Query: 852 MEPLTTLEFSE-------KEDHFTATDIHKGASYVFRLSARNKVGFG----EEMVKEISI 900
           ++P   L            E H     ++ G +Y F + A    GFG      +  +IS 
Sbjct: 529 LDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISA 588

Query: 901 PE--EVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 947
           P   E  T  P N      T T++ +  +P     R   ++ Y L+ ++
Sbjct: 589 PSMPEYDTDTPLN-----ETDTTITVMLKP--AQSRGAPVSVYQLVVKE 630


>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
            [Homo sapiens]
          Length = 1445

 Score =  459 bits (1182), Expect = e-129
 Identities = 264/678 (38%), Positives = 373/678 (55%), Gaps = 52/678 (7%)

Query: 1261 VLAVVFIICIVIAILLYKRKRAESDSRKSSIPNN-KEIPSHHPTDPVELRRLNFQT---- 1315
            V++ +  +C+++ I +    R  +  +    P   +E+PS         R+  FQT    
Sbjct: 743  VVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKC-FQTAHFY 801

Query: 1316 ------PGMASHPPIPILELAD------------HIERLKANDNLKFSQEYESID---PG 1354
                  P +  +  IPI+ + D            HI  L +N+   FS+++E +      
Sbjct: 802  VEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTAD 861

Query: 1355 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAY 1412
               T EHSN   NK KNRY N++AYDHSRV L  + G     SDY+NANY+DGY K  AY
Sbjct: 862  MNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAY 921

Query: 1413 IATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL 1472
            IATQG L  TF DFWRMIWEQ +  +VM+T L E+ R KCDQYWP+  +E +G + VTL 
Sbjct: 922  IATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLK 981

Query: 1473 DTVELATYCVRTFALYKN-----------GSSEKREVRQFQFTAWPDHGVPEHPTPFLAF 1521
             T   A Y VR F++              G   +R V Q+ +T WPD GVPE+  P L F
Sbjct: 982  STKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTF 1041

Query: 1522 LRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNY 1581
            +RR      P+ GP++VHCSAGVGRTG +IVID+ML++IK + TV++ G +  +R QRNY
Sbjct: 1042 VRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNY 1101

Query: 1582 MVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASS 1641
            +VQTE+QYIFIHDALLEA+    TEV +  L++Y+  +     G   T +E +FK +   
Sbjct: 1102 LVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVG-GKTRLEKQFKLVTQC 1160

Query: 1642 KAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAY 1701
             A      SA   CNK KNR  +++P E  RV L P+ G++G+DYINAS+I GY +   +
Sbjct: 1161 NAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEF 1220

Query: 1702 IATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA-ERSARYQYFVV-- 1758
            I TQ PL  TT+DFWRM+W+HN+ I+VML   + +  ++   YWP+ E S   + F V  
Sbjct: 1221 IITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTL 1279

Query: 1759 ---DPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVH 1815
               D +   N  Q I+ +F +   +D     VR FQ   WP    P S     + I  + 
Sbjct: 1280 ISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVI- 1336

Query: 1816 KTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQ 1875
              +E   +DGP  VH   G    G+   L+ + +++  E  VD+FQ  KM+   RP +  
Sbjct: 1337 -KEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFT 1395

Query: 1876 TEDQYQFSYRAALEYLGS 1893
              +QYQF Y+A L  + +
Sbjct: 1396 DIEQYQFIYKAMLSLVST 1413



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 19/58 (32%), Positives = 30/58 (51%), Gaps = 1/58 (1%)

Query: 697 VPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKD 754
           V S PP  ++V+ +N T+++VSW  P     H  I  Y + Y   +N + K +   KD
Sbjct: 345 VCSSPPIHMKVQPLNQTALQVSWSQP-ETIYHPPIMNYMISYSWTKNEDEKEKTFTKD 401


>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
            precursor [Homo sapiens]
          Length = 1436

 Score =  454 bits (1169), Expect = e-127
 Identities = 313/954 (32%), Positives = 463/954 (48%), Gaps = 101/954 (10%)

Query: 1017 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 1063
            ++  + L WE P+  N  +  ++I Y   +       V G           T  +  NL 
Sbjct: 499  LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558

Query: 1064 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 1118
            P  +Y F +   T +G     L    T  +AP       P+ +G++  +  ITV L P  
Sbjct: 559  PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616

Query: 1119 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 1177
                 I  Y +I+   ++ R + ++      +     L  E +  R  + Y G E+    
Sbjct: 617  GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673

Query: 1178 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 1236
               A        FT+GD++ Y GF N  L+  + Y ++F  A     E+++         
Sbjct: 674  LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727

Query: 1237 VVSMDLDPQPITD--EEEGLIW-VVGPVLAVVFIICIVIAILLYKRK------------- 1280
                   P  ++   EE GLI  +    LAV+ ++   I +++ K K             
Sbjct: 728  ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQ 787

Query: 1281 -----------------------------------RAESDSRKSSIPNNKEIPSHHPTDP 1305
                                                   D R   +     +    P  P
Sbjct: 788  EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRP 847

Query: 1306 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLE 1365
               +   + T  +  HP + + +L  HI ++K  +   F QEYES   G    W+ +  +
Sbjct: 848  CGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKK 901

Query: 1366 VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGD 1425
                 +R   + AYD  RV L  + G P +DY+NANYIDGY + N +IATQG  PE   D
Sbjct: 902  DKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYD 961

Query: 1426 FWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTF 1485
            FWRM+W++  +++VM+TKL E  RVKC +YWP   ++T+G +++ L+ T  LA Y VRTF
Sbjct: 962  FWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTF 1020

Query: 1486 ALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVG 1545
            AL + G S + EVRQF FTAWP+HGVP H T  LAF+RRVK   PPDAGP+V+HCSAG G
Sbjct: 1021 ALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTG 1080

Query: 1546 RTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNT 1605
            RTGC+IV+D ML+  + E  VDIY  V  + ++R  M+QTE+QYIFIHDA+LEA  CG T
Sbjct: 1081 RTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGET 1140

Query: 1606 EVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLV 1663
             +P     A  +++ +I+   N + +  EF+ L S            A LP N+ KNR +
Sbjct: 1141 TIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSM 1200

Query: 1664 NIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE 1721
            +++P +    CL  +   +G  ++YINA+  D Y +  A+I T  PL  TT DFWR++++
Sbjct: 1201 DVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYD 1257

Query: 1722 HNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR 1780
            +  T +VML +L +      C QYWP     +Y    V+ M+       + R F+V +  
Sbjct: 1258 YGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNIS 1317

Query: 1781 DGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGR 1837
              Q     VR FQF  W   +  P S + F+  + +V K + + G DG   VHC  G GR
Sbjct: 1318 RLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGR 1376

Query: 1838 TGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1891
            +G F   + VLE +R   +VD+F   K LR  +P MV+T DQY F Y  ALEYL
Sbjct: 1377 SGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1430



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 85/366 (23%), Positives = 148/366 (40%), Gaps = 46/366 (12%)

Query: 287 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 342
           Y CV+ +  G  +   A++ VK  P P   P +  +  T + +  ++ +     P+    
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321

Query: 343 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 400
           I+++       + E+  V+   Y +  L P ++YE  V+     + G G P  P++++T 
Sbjct: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379

Query: 401 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 460
              P  AP+ +    + +  + +QW    EP G        YT+    H      HN   
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435

Query: 461 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 506
            +           TI NL+P +   V+++     G     +    +D  V   +G+  + 
Sbjct: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493

Query: 507 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 555
           L F      E  I L W  P+  +  I  YE+ Y+  E         G  + I+ +   T
Sbjct: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550

Query: 556 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSKPSAPPQDI-SCTSPSSTSI 613
            +    L P + Y F + AR+ +G G A+  EI+  T  S PS    D+ S    S  +I
Sbjct: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEIT--TNISAPSFDYADMPSPLGESENTI 608

Query: 614 LVSWQP 619
            V  +P
Sbjct: 609 TVLLRP 614



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)

Query: 352 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 411
           E  K   GV+  RY++  L PY +   R+V  N  GR    E V  QT E  PS    + 
Sbjct: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493

Query: 412 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 465
                    I ++W+EP+EPNG I  Y + Y    + DP  +V    +    + +     
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553

Query: 466 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 518
             NL P  TY   V A T  G G  ++  ++ T    P         PL    E E+  +
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609

Query: 519 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 554
           +LL     R   I+ Y+++    E    +R+  EPG
Sbjct: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 71/277 (25%), Positives = 107/277 (38%), Gaps = 46/277 (16%)

Query: 453 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 510
           W + +    Q   + +L P   Y + VL  T  GDG           TG PG PL  +  
Sbjct: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379

Query: 511 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 548
            AEP                + L W P      R  T     L Y       H +  R  
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438

Query: 549 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 607
           +  E G S Y ++ L P    + RL   +P+G      E++ +T +  PS    +    +
Sbjct: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGK-EVTFQTDEDVPSGIAAESLTFT 497

Query: 608 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDK-----PHEILGIPSDTTKYLLE 662
           P    I + W+ P  ++ NG+IT+Y I Y +++  D       P   +    + T ++  
Sbjct: 498 PLEDMIFLKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFS 555

Query: 663 QLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPS 699
            L   T Y  +V A T  G G  +L+  I TN   PS
Sbjct: 556 NLHPGTTYLFSVRARTGKGFGQAALTE-ITTNISAPS 591



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 55/262 (20%), Positives = 107/262 (40%), Gaps = 21/262 (8%)

Query: 556 SYRLQGLKPNSLYYFRLAARSPQ--GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSI 613
           +Y+L  L P++ Y   +    P   G G     + +RT  ++P   P+ ++     +  +
Sbjct: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400

Query: 614 LVSWQPPP--VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYR 671
            + W+P    V + +         YT     +    E +      ++Y ++ L  +    
Sbjct: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460

Query: 672 ITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVK----VSWRSPVPNKQ 727
           + +      G   E   V  +T+EDVPSG    +  E++  T ++    + W  P   + 
Sbjct: 461 VRLVLTNPEGR-KEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEP--QEP 513

Query: 728 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTV 787
           +G I  Y++ Y  +E+ +P          ++  + E    T H  + S L P T+Y  +V
Sbjct: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNE----TYH--VFSNLHPGTTYLFSV 567

Query: 788 TAYTTKGDGARSKPKLVSTTGA 809
            A T KG G  +  ++ +   A
Sbjct: 568 RARTGKGFGQAALTEITTNISA 589



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 59/233 (25%), Positives = 86/233 (36%), Gaps = 22/233 (9%)

Query: 777 LQPETSYSLTVTAYTTKGDGA--RSKPKLVSTTGAVP---GKPRLVINHTQMNTALIQWH 831
           L P+T Y ++V   T  GDG   R  P L+S T           L     Q     +QW 
Sbjct: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405

Query: 832 P------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKE-DHFTATDIHKGASYVFRLSA 884
           P         T+     Y    G    + +     +E+    +T  ++    +   RL  
Sbjct: 406 PLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVL 465

Query: 885 RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLL 944
            N  G  E         E+VP+G      +       + L W+ P   E NG+IT+Y + 
Sbjct: 466 TNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEP--QEPNGLITQYEIS 523

Query: 945 YRDI-------NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG 990
           Y+ I       N+P        +  +T    + L P TTY   VRA T KG G
Sbjct: 524 YQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 68/351 (19%), Positives = 127/351 (36%), Gaps = 35/351 (9%)

Query: 570 FRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 628
           +R  +++P+G G S  AE+  +   + P APPQ +       T +++      +   +G 
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPT-PIAPPQLLRA---GPTYLIIQLNTNSIIG-DGP 316

Query: 629 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPES 686
           I    I+Y    G   + H +         Y L  L+  TEY I+V  T   D G G   
Sbjct: 317 IVRKEIEYRMARGPWAEVHAV-----SLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPG 371

Query: 687 LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPN--KQHGQIRGYQVHYVRMENG 744
             ++ RT    P   P+ +    + +  + + W     N  + H        HY     G
Sbjct: 372 PPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTL---G 428

Query: 745 EPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLV 804
               Q + + V        +         I  L P  +  + +     +G     +    
Sbjct: 429 SSHNQTIRECVKTEQGVSRYT--------IKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480

Query: 805 STTGAVPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDME--------PL 855
           +      G     +  T +   + ++W  P +  G +  Y + +   +          P 
Sbjct: 481 TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540

Query: 856 TTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 906
            T+     E +   +++H G +Y+F + AR   GFG+  + EI+     P+
Sbjct: 541 RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591


>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
            precursor [Homo sapiens]
          Length = 1446

 Score =  449 bits (1156), Expect = e-126
 Identities = 249/615 (40%), Positives = 351/615 (57%), Gaps = 19/615 (3%)

Query: 1285 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 1344
            D R   +     +    P  P   +   + T  +  HP + + +L  HI ++K  +   F
Sbjct: 837  DQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGF 894

Query: 1345 SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID 1404
             QEYES   G    W+ +  +     +R   + AYD  RV L  + G P +DY+NANYID
Sbjct: 895  KQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYID 950

Query: 1405 GYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH 1464
            GY + N +IATQG  PE   DFWRM+W++  +++VM+TKL E  RVKC +YWP   ++T+
Sbjct: 951  GYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTY 1009

Query: 1465 GLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRR 1524
            G +++ L+ T  LA Y VRTFAL + G S + EVRQF FTAWP+HGVP H T  LAF+RR
Sbjct: 1010 GDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRR 1069

Query: 1525 VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ 1584
            VK   PPDAGP+V+HCSAG GRTGC+IV+D ML+  + E  VDIY  V  + ++R  M+Q
Sbjct: 1070 VKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQ 1129

Query: 1585 TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SK 1642
            TE+QYIFIHDA+LEA  CG T +P     A  +++ +I+   N + +  EF+ L S    
Sbjct: 1130 TEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPP 1189

Query: 1643 AHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKA 1700
                    A LP N+ KNR ++++P +    CL  +   +G  ++YINA+  D Y +  A
Sbjct: 1190 LDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAA 1246

Query: 1701 YIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVD 1759
            +I T  PL  TT DFWR+++++  T +VML +L +      C QYWP     +Y    V+
Sbjct: 1247 FIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVE 1306

Query: 1760 PMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHK 1816
             M+       + R F+V +    Q     VR FQF  W   +  P S + F+  + +V K
Sbjct: 1307 FMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDK 1366

Query: 1817 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1876
             + + G DG   VHC  G GR+G F   + VLE +R   +VD+F   K LR  +P MV+T
Sbjct: 1367 WQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVET 1425

Query: 1877 EDQYQFSYRAALEYL 1891
             DQY F Y  ALEYL
Sbjct: 1426 MDQYHFCYDVALEYL 1440



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 85/366 (23%), Positives = 148/366 (40%), Gaps = 46/366 (12%)

Query: 287 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 342
           Y CV+ +  G  +   A++ VK  P P   P +  +  T + +  ++ +     P+    
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321

Query: 343 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 400
           I+++       + E+  V+   Y +  L P ++YE  V+     + G G P  P++++T 
Sbjct: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379

Query: 401 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 460
              P  AP+ +    + +  + +QW    EP G        YT+    H      HN   
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435

Query: 461 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 506
            +           TI NL+P +   V+++     G     +    +D  V   +G+  + 
Sbjct: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493

Query: 507 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 555
           L F      E  I L W  P+  +  I  YE+ Y+  E         G  + I+ +   T
Sbjct: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550

Query: 556 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSKPSAPPQDI-SCTSPSSTSI 613
            +    L P + Y F + AR+ +G G A+  EI+  T  S PS    D+ S    S  +I
Sbjct: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEIT--TNISAPSFDYADMPSPLGESENTI 608

Query: 614 LVSWQP 619
            V  +P
Sbjct: 609 TVLLRP 614



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)

Query: 352 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 411
           E  K   GV+  RY++  L PY +   R+V  N  GR    E V  QT E  PS    + 
Sbjct: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493

Query: 412 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 465
                    I ++W+EP+EPNG I  Y + Y    + DP  +V    +    + +     
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553

Query: 466 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 518
             NL P  TY   V A T  G G  ++  ++ T    P         PL    E E+  +
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609

Query: 519 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 554
           +LL     R   I+ Y+++    E    +R+  EPG
Sbjct: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 71/277 (25%), Positives = 107/277 (38%), Gaps = 46/277 (16%)

Query: 453 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 510
           W + +    Q   + +L P   Y + VL  T  GDG           TG PG PL  +  
Sbjct: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379

Query: 511 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 548
            AEP                + L W P      R  T     L Y       H +  R  
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438

Query: 549 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 607
           +  E G S Y ++ L P    + RL   +P+G      E++ +T +  PS    +    +
Sbjct: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGK-EVTFQTDEDVPSGIAAESLTFT 497

Query: 608 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDK-----PHEILGIPSDTTKYLLE 662
           P    I + W+ P  ++ NG+IT+Y I Y +++  D       P   +    + T ++  
Sbjct: 498 PLEDMIFLKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFS 555

Query: 663 QLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPS 699
            L   T Y  +V A T  G G  +L+  I TN   PS
Sbjct: 556 NLHPGTTYLFSVRARTGKGFGQAALTE-ITTNISAPS 591



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 55/262 (20%), Positives = 107/262 (40%), Gaps = 21/262 (8%)

Query: 556 SYRLQGLKPNSLYYFRLAARSPQ--GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSI 613
           +Y+L  L P++ Y   +    P   G G     + +RT  ++P   P+ ++     +  +
Sbjct: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400

Query: 614 LVSWQPPP--VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYR 671
            + W+P    V + +         YT     +    E +      ++Y ++ L  +    
Sbjct: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460

Query: 672 ITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVK----VSWRSPVPNKQ 727
           + +      G   E   V  +T+EDVPSG    +  E++  T ++    + W  P   + 
Sbjct: 461 VRLVLTNPEGR-KEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEP--QEP 513

Query: 728 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTV 787
           +G I  Y++ Y  +E+ +P          ++  + E    T H  + S L P T+Y  +V
Sbjct: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNE----TYH--VFSNLHPGTTYLFSV 567

Query: 788 TAYTTKGDGARSKPKLVSTTGA 809
            A T KG G  +  ++ +   A
Sbjct: 568 RARTGKGFGQAALTEITTNISA 589



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 59/233 (25%), Positives = 86/233 (36%), Gaps = 22/233 (9%)

Query: 777 LQPETSYSLTVTAYTTKGDGA--RSKPKLVSTTGAVP---GKPRLVINHTQMNTALIQWH 831
           L P+T Y ++V   T  GDG   R  P L+S T           L     Q     +QW 
Sbjct: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405

Query: 832 P------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKE-DHFTATDIHKGASYVFRLSA 884
           P         T+     Y    G    + +     +E+    +T  ++    +   RL  
Sbjct: 406 PLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVL 465

Query: 885 RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLL 944
            N  G  E         E+VP+G      +       + L W+ P   E NG+IT+Y + 
Sbjct: 466 TNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEP--QEPNGLITQYEIS 523

Query: 945 YRDI-------NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG 990
           Y+ I       N+P        +  +T    + L P TTY   VRA T KG G
Sbjct: 524 YQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 68/351 (19%), Positives = 127/351 (36%), Gaps = 35/351 (9%)

Query: 570 FRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 628
           +R  +++P+G G S  AE+  +   + P APPQ +       T +++      +   +G 
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPT-PIAPPQLLRA---GPTYLIIQLNTNSIIG-DGP 316

Query: 629 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPES 686
           I    I+Y    G   + H +         Y L  L+  TEY I+V  T   D G G   
Sbjct: 317 IVRKEIEYRMARGPWAEVHAV-----SLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPG 371

Query: 687 LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPN--KQHGQIRGYQVHYVRMENG 744
             ++ RT    P   P+ +    + +  + + W     N  + H        HY     G
Sbjct: 372 PPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTL---G 428

Query: 745 EPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLV 804
               Q + + V        +         I  L P  +  + +     +G     +    
Sbjct: 429 SSHNQTIRECVKTEQGVSRYT--------IKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480

Query: 805 STTGAVPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDME--------PL 855
           +      G     +  T +   + ++W  P +  G +  Y + +   +          P 
Sbjct: 481 TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540

Query: 856 TTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 906
            T+     E +   +++H G +Y+F + AR   GFG+  + EI+     P+
Sbjct: 541 RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 63/285 (22%), Positives = 111/285 (38%), Gaps = 34/285 (11%)

Query: 1017 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 1063
            ++  + L WE P+  N  +  ++I Y   +       V G           T  +  NL 
Sbjct: 499  LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558

Query: 1064 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 1118
            P  +Y F +   T +G     L    T  +AP       P+ +G++  +  ITV L P  
Sbjct: 559  PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616

Query: 1119 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 1177
                 I  Y +I+   ++ R + ++      +     L  E +  R  + Y G E+    
Sbjct: 617  GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673

Query: 1178 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 1236
               A        FT+GD++ Y GF N  L+  + Y ++F  A     E+++         
Sbjct: 674  LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727

Query: 1237 VVSMDLDPQPIT--DEEEGLI-WVVGPVLAVVFIICIVIAILLYK 1278
                   P  ++   EE GLI  +    LAV+ ++   I +++ K
Sbjct: 728  ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRK 772


>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
            precursor [Homo sapiens]
          Length = 1442

 Score =  448 bits (1152), Expect = e-125
 Identities = 313/960 (32%), Positives = 463/960 (48%), Gaps = 107/960 (11%)

Query: 1017 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 1063
            ++  + L WE P+  N  +  ++I Y   +       V G           T  +  NL 
Sbjct: 499  LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558

Query: 1064 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 1118
            P  +Y F +   T +G     L    T  +AP       P+ +G++  +  ITV L P  
Sbjct: 559  PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616

Query: 1119 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 1177
                 I  Y +I+   ++ R + ++      +     L  E +  R  + Y G E+    
Sbjct: 617  GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673

Query: 1178 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 1236
               A        FT+GD++ Y GF N  L+  + Y ++F  A     E+++         
Sbjct: 674  LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727

Query: 1237 VVSMDLDPQPITD--EEEGLIW-VVGPVLAVVFIICIVIAILLYKRK------------- 1280
                   P  ++   EE GLI  +    LAV+ ++   I +++ K K             
Sbjct: 728  ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQ 787

Query: 1281 -----------------------------------RAESDSRKSSIPNNKEIPSHHPTDP 1305
                                                   D R   +     +    P  P
Sbjct: 788  EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRP 847

Query: 1306 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLE 1365
               +   + T  +  HP + + +L  HI ++K  +   F QEYES   G    W+ +  +
Sbjct: 848  CGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKK 901

Query: 1366 VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSL 1419
                 +R   + AYD  RV L  + G P +DY+NANYID      GY + N +IATQG  
Sbjct: 902  DKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPK 961

Query: 1420 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1479
            PE   DFWRM+W++  +++VM+TKL E  RVKC +YWP   ++T+G +++ L+ T  LA 
Sbjct: 962  PEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAE 1020

Query: 1480 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVH 1539
            Y VRTFAL + G S + EVRQF FTAWP+HGVP H T  LAF+RRVK   PPDAGP+V+H
Sbjct: 1021 YVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIH 1080

Query: 1540 CSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEA 1599
            CSAG GRTGC+IV+D ML+  + E  VDIY  V  + ++R  M+QTE+QYIFIHDA+LEA
Sbjct: 1081 CSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA 1140

Query: 1600 VTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNK 1657
              CG T +P     A  +++ +I+   N + +  EF+ L S            A LP N+
Sbjct: 1141 CLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR 1200

Query: 1658 FKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDF 1715
             KNR ++++P +    CL  +   +G  ++YINA+  D Y +  A+I T  PL  TT DF
Sbjct: 1201 DKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDF 1257

Query: 1716 WRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1774
            WR+++++  T +VML +L +      C QYWP     +Y    V+ M+       + R F
Sbjct: 1258 WRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVF 1317

Query: 1775 KVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC 1831
            +V +    Q     VR FQF  W   +  P S + F+  + +V K + + G DG   VHC
Sbjct: 1318 RVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHC 1376

Query: 1832 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1891
              G GR+G F   + VLE +R   +VD+F   K LR  +P MV+T DQY F Y  ALEYL
Sbjct: 1377 LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1436



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 85/366 (23%), Positives = 148/366 (40%), Gaps = 46/366 (12%)

Query: 287 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 342
           Y CV+ +  G  +   A++ VK  P P   P +  +  T + +  ++ +     P+    
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321

Query: 343 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 400
           I+++       + E+  V+   Y +  L P ++YE  V+     + G G P  P++++T 
Sbjct: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379

Query: 401 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 460
              P  AP+ +    + +  + +QW    EP G        YT+    H      HN   
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435

Query: 461 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 506
            +           TI NL+P +   V+++     G     +    +D  V   +G+  + 
Sbjct: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493

Query: 507 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 555
           L F      E  I L W  P+  +  I  YE+ Y+  E         G  + I+ +   T
Sbjct: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550

Query: 556 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSKPSAPPQDI-SCTSPSSTSI 613
            +    L P + Y F + AR+ +G G A+  EI+  T  S PS    D+ S    S  +I
Sbjct: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEIT--TNISAPSFDYADMPSPLGESENTI 608

Query: 614 LVSWQP 619
            V  +P
Sbjct: 609 TVLLRP 614



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)

Query: 352 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 411
           E  K   GV+  RY++  L PY +   R+V  N  GR    E V  QT E  PS    + 
Sbjct: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493

Query: 412 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 465
                    I ++W+EP+EPNG I  Y + Y    + DP  +V    +    + +     
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553

Query: 466 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 518
             NL P  TY   V A T  G G  ++  ++ T    P         PL    E E+  +
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609

Query: 519 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 554
           +LL     R   I+ Y+++    E    +R+  EPG
Sbjct: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 71/277 (25%), Positives = 107/277 (38%), Gaps = 46/277 (16%)

Query: 453 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 510
           W + +    Q   + +L P   Y + VL  T  GDG           TG PG PL  +  
Sbjct: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379

Query: 511 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 548
            AEP                + L W P      R  T     L Y       H +  R  
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438

Query: 549 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 607
           +  E G S Y ++ L P    + RL   +P+G      E++ +T +  PS    +    +
Sbjct: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGK-EVTFQTDEDVPSGIAAESLTFT 497

Query: 608 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDK-----PHEILGIPSDTTKYLLE 662
           P    I + W+ P  ++ NG+IT+Y I Y +++  D       P   +    + T ++  
Sbjct: 498 PLEDMIFLKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFS 555

Query: 663 QLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPS 699
            L   T Y  +V A T  G G  +L+  I TN   PS
Sbjct: 556 NLHPGTTYLFSVRARTGKGFGQAALTE-ITTNISAPS 591



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 55/262 (20%), Positives = 107/262 (40%), Gaps = 21/262 (8%)

Query: 556 SYRLQGLKPNSLYYFRLAARSPQ--GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSI 613
           +Y+L  L P++ Y   +    P   G G     + +RT  ++P   P+ ++     +  +
Sbjct: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400

Query: 614 LVSWQPPP--VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYR 671
            + W+P    V + +         YT     +    E +      ++Y ++ L  +    
Sbjct: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460

Query: 672 ITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVK----VSWRSPVPNKQ 727
           + +      G   E   V  +T+EDVPSG    +  E++  T ++    + W  P   + 
Sbjct: 461 VRLVLTNPEGR-KEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEP--QEP 513

Query: 728 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTV 787
           +G I  Y++ Y  +E+ +P          ++  + E    T H  + S L P T+Y  +V
Sbjct: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNE----TYH--VFSNLHPGTTYLFSV 567

Query: 788 TAYTTKGDGARSKPKLVSTTGA 809
            A T KG G  +  ++ +   A
Sbjct: 568 RARTGKGFGQAALTEITTNISA 589



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 59/233 (25%), Positives = 86/233 (36%), Gaps = 22/233 (9%)

Query: 777 LQPETSYSLTVTAYTTKGDGA--RSKPKLVSTTGAVP---GKPRLVINHTQMNTALIQWH 831
           L P+T Y ++V   T  GDG   R  P L+S T           L     Q     +QW 
Sbjct: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405

Query: 832 P------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKE-DHFTATDIHKGASYVFRLSA 884
           P         T+     Y    G    + +     +E+    +T  ++    +   RL  
Sbjct: 406 PLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVL 465

Query: 885 RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLL 944
            N  G  E         E+VP+G      +       + L W+ P   E NG+IT+Y + 
Sbjct: 466 TNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEP--QEPNGLITQYEIS 523

Query: 945 YRDI-------NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG 990
           Y+ I       N+P        +  +T    + L P TTY   VRA T KG G
Sbjct: 524 YQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 68/351 (19%), Positives = 127/351 (36%), Gaps = 35/351 (9%)

Query: 570 FRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 628
           +R  +++P+G G S  AE+  +   + P APPQ +       T +++      +   +G 
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPT-PIAPPQLLRA---GPTYLIIQLNTNSIIG-DGP 316

Query: 629 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPES 686
           I    I+Y    G   + H +         Y L  L+  TEY I+V  T   D G G   
Sbjct: 317 IVRKEIEYRMARGPWAEVHAV-----SLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPG 371

Query: 687 LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPN--KQHGQIRGYQVHYVRMENG 744
             ++ RT    P   P+ +    + +  + + W     N  + H        HY     G
Sbjct: 372 PPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTL---G 428

Query: 745 EPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLV 804
               Q + + V        +         I  L P  +  + +     +G     +    
Sbjct: 429 SSHNQTIRECVKTEQGVSRYT--------IKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480

Query: 805 STTGAVPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDME--------PL 855
           +      G     +  T +   + ++W  P +  G +  Y + +   +          P 
Sbjct: 481 TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540

Query: 856 TTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 906
            T+     E +   +++H G +Y+F + AR   GFG+  + EI+     P+
Sbjct: 541 RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591


>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
            precursor [Homo sapiens]
          Length = 2315

 Score =  424 bits (1089), Expect = e-118
 Identities = 245/615 (39%), Positives = 345/615 (56%), Gaps = 43/615 (6%)

Query: 1315 TPGMASHPPIPILELAD------------HIERLKANDNL--------KFSQEYESIDPG 1354
            +P + S PP PI  ++D            H+  L A+           +F QE +S    
Sbjct: 1678 SPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVD 1737

Query: 1355 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAY 1412
               T + SN   NK KNRY N++AYDHSRV L+ +    G  +DY+NANY+DGY +  AY
Sbjct: 1738 LGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAY 1797

Query: 1413 IATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL 1472
            IA QG L  T  DFWRMIWE     +VM+T L E+ R KCDQYWP+ G+E +G   VT  
Sbjct: 1798 IAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQK 1857

Query: 1473 DTVELATYCVRTFAL----YKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFLAFLRR 1524
                LA Y VR F L     K GS + R     V Q+ +T WPD GVPE+  P L F+R+
Sbjct: 1858 SVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRK 1917

Query: 1525 VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ 1584
                     GP+VVHCSAGVGRTG +IV+D+ML++I+HE TV+I+G +  +R+QRNY+VQ
Sbjct: 1918 AAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQ 1977

Query: 1585 TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAH 1644
            TE+QY+FIHD L+EA+    TEV   +++AY+  L  I      T +E +F+ L+ S   
Sbjct: 1978 TEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALL-IPGPAGKTKLEKQFQLLSQSNIQ 2036

Query: 1645 TSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIAT 1704
             S + +A   CN+ KNR  +I+P E +RV +  + G EG+DYINAS+I GY Q   +I T
Sbjct: 2037 QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIIT 2095

Query: 1705 QGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE 1763
            Q PL  T +DFWRM+W+HN+ +VVM+   + M  ++   YWP  +     + F V  MAE
Sbjct: 2096 QHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAE 2154

Query: 1764 -----YNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTK 1818
                  N  + I+++F +   +D     VR FQ   WP    P S     + I  +   +
Sbjct: 2155 EHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVI--KE 2210

Query: 1819 EQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED 1878
            E   +DGP+ VH   G    G F  L+ ++ ++  E  VD++Q  KM+   RP +    +
Sbjct: 2211 EAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIE 2270

Query: 1879 QYQFSYRAALEYLGS 1893
            QYQF Y+  L  + +
Sbjct: 2271 QYQFLYKVILSLVST 2285



 Score =  115 bits (288), Expect = 4e-25
 Identities = 77/264 (29%), Positives = 129/264 (48%), Gaps = 10/264 (3%)

Query: 1355 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIA 1414
            QQ  +  +  + N+ KNR +++I  + SRV +S++ G  G+DY+NA+YI GY + N +I 
Sbjct: 2036 QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFII 2094

Query: 1415 TQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH-GLVQVTLLD 1473
            TQ  L  T  DFWRMIW+  +  VVM+   +  +  +   YWP++    +    +VTL+ 
Sbjct: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKDEPINCESFKVTLMA 2153

Query: 1474 TVELAT-----YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC 1528
                         ++ F L         EVR FQ   WP+   P   T  L  + + +  
Sbjct: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAA 2213

Query: 1529 NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQ 1588
            N    GPM+VH   G    G F  +  ++ +++ E +VD+Y    ++   R  +    +Q
Sbjct: 2214 NRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQ 2271

Query: 1589 YIFIHDALLEAVTCGNTEVPARNL 1612
            Y F++  +L  V+    E P+ +L
Sbjct: 2272 YQFLYKVILSLVSTRQEENPSTSL 2295



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 18/54 (33%), Positives = 32/54 (59%), Gaps = 1/54 (1%)

Query: 597 SAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEIL 650
           S+ P+++     + TS+LV+W+ P V     +I ++++ Y  +DGED   HE L
Sbjct: 312 SSEPENVQADPENYTSLLVTWERPRVVYDT-MIEKFAVLYQQLDGEDQTKHEFL 364



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 7/83 (8%)

Query: 505 QPLNFKAEPESETSILLSWTPPR---SDTIANYELVYK--DGEHGEEQRITIE--PGTSY 557
           +P N +A+PE+ TS+L++W  PR      I  + ++Y+  DGE   +     +       
Sbjct: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGA 373

Query: 558 RLQGLKPNSLYYFRLAARSPQGL 580
            L  L PN  Y  ++ A    GL
Sbjct: 374 ILNNLLPNMSYVLQIVAICTNGL 396



 Score = 33.1 bits (74), Expect = 2.7
 Identities = 56/231 (24%), Positives = 90/231 (38%), Gaps = 30/231 (12%)

Query: 401 EQAPSSAPRDVQARMLSSTTILVQWKEPEEP-NGQIQGYRVYYTM----DPTQHVNNWMK 455
           E   SS P +VQA   + T++LV W+ P    +  I+ + V Y      D T+H   ++ 
Sbjct: 308 EAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKH--EFLT 365

Query: 456 HNVADSQITTIGNLVPQKTYSVKVLAFTSIG-DGPLSSDIQVITQTGVP---------GQ 505
               D     + NL+P  +Y ++++A  + G  G  S  + V   T  P         G 
Sbjct: 366 DGYQDLG-AILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPELIGT 424

Query: 506 PLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPN 565
               K E E +     +   P  D+  N ++  K+ +        I   T Y   G K N
Sbjct: 425 EEIIKEEEEGKDIEEGAIVNPGRDSATN-QIRKKEPQ--------ISTTTHYNRIGTKYN 475

Query: 566 SLYYFRLAARSPQGLGASTAEISARTMQSKP---SAPPQDISCTSPSSTSI 613
                R   R  +  G      ++    S+P    A  +DIS TS + T +
Sbjct: 476 EAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTEL 526


>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
            precursor [Homo sapiens]
          Length = 1256

 Score =  396 bits (1018), Expect = e-110
 Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)

Query: 1323 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 1381
            PI    L +  +R  A++   F  E++SI     +F  + +    N+ KNRY +++ YD+
Sbjct: 582  PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 641

Query: 1382 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1441
            +RV LS I G  GS+Y+NA+YIDG+++   YIA QG   ET  DFWRMIWEQ++  +VM+
Sbjct: 642  NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 701

Query: 1442 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1498
            T+ EE +R KC +YWPS   GT   G V V +        Y ++   +  K   +  REV
Sbjct: 702  TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 761

Query: 1499 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1558
               QFT+WPDHGVPE P   L   RRV   +   +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 762  THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 821

Query: 1559 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1618
             ++ E  VD+YG+V  +R QR  MVQ E QYI IH AL+E    G TEV    L+ Y+  
Sbjct: 822  GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 881

Query: 1619 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1676
            + + +     + +E EF+RL S ++  ++ I  N   NK KNR  N++PY+  RV L+  
Sbjct: 882  MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 940

Query: 1677 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1719
                                  E S YINASFI  Y + +  IA QGPL ET  DFW+M+
Sbjct: 941  LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1000

Query: 1720 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1779
            ++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR F++  +
Sbjct: 1001 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1059

Query: 1780 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1831
            +   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ +HC
Sbjct: 1060 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1119

Query: 1832 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1884
              G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T +QYQF Y
Sbjct: 1120 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172



 Score =  197 bits (501), Expect = 8e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 1651 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1710
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681

Query: 1711 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1768
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 682  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741

Query: 1769 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1827
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 742  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799

Query: 1828 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1887
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY   ++A 
Sbjct: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859

Query: 1888 LEY 1890
            +EY
Sbjct: 860  VEY 862



 Score =  156 bits (395), Expect = 2e-37
 Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)

Query: 1324 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 1378
            + + EL  ++  +K  D          E++ +   + +  +H  N E NK KNR +NVI 
Sbjct: 870  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 929

Query: 1379 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1419
            YD++RV L         S  +    SD          Y+NA++I  Y K    IA QG L
Sbjct: 930  YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 989

Query: 1420 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1479
             ET GDFW+MI++++   +VM+T+L+   +  C QYW   G +T+G ++V L DT + +T
Sbjct: 990  KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 1048

Query: 1480 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1532
            Y +R F L  +   + R V Q+Q+T W    +P  P   ++ ++ VK   P         
Sbjct: 1049 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 1108

Query: 1533 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1589
               + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V  +R  R  MV T +QY
Sbjct: 1109 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1168

Query: 1590 IFIHDALLEAVTCGNTEVPARN 1611
             F++D +       N +V   N
Sbjct: 1169 QFLYDVIASTYPAQNGQVKKNN 1190



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 22/226 (9%)

Query: 417 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 474
           + TTI ++WK  E            +T D TQ++    +  + + D++   + NL P+  
Sbjct: 267 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 314

Query: 475 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 534
           Y        +      +S I + T  G PG+P       E+    +++W PP+  +  N+
Sbjct: 315 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 372

Query: 535 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEISARTM 592
            L Y   +  E+  + ++     Y LQ LKP + Y   L A     +  + +A +   T 
Sbjct: 373 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT 430

Query: 593 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 638
           +S P +   +++ +  S  S+ V  +PP    +NG    Y ++  A
Sbjct: 431 KSAPPSQVWNMTVSMTSDNSMHVKCRPP--RDRNGPHERYHLEVEA 474



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 29/124 (23%), Positives = 50/124 (40%), Gaps = 11/124 (8%)

Query: 600 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 659
           PQ I C S ++   +++W PP     N   T   IK T  D         L +  +  KY
Sbjct: 345 PQIIFCRSEAAHQGVITWNPPQRSFHN--FTLCYIKETEKD--------CLNLDKNLIKY 394

Query: 660 LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR-TNEDVPSGPPRKVEVEAVNSTSVKVS 718
            L+ L+ +T+Y +++ A+          + +   T +  P      + V   +  S+ V 
Sbjct: 395 DLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVK 454

Query: 719 WRSP 722
            R P
Sbjct: 455 CRPP 458



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 10/127 (7%)

Query: 774 ISGLQPETSYSLTVTAYT-TKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQW 830
           +  L+P T Y L++ AY   K     S      TT + P      + ++ T  N+  ++ 
Sbjct: 396 LQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKC 455

Query: 831 HPPVDTFGPLQGYRLKFGRKDMEPLTTL--EFSEKEDHFTATDIHKGASYVFRLSARNKV 888
            PP D  GP + Y L     ++E   TL    S K   F   D+     Y F+    N  
Sbjct: 456 RPPRDRNGPHERYHL-----EVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGD 510

Query: 889 GFGEEMV 895
             GE  +
Sbjct: 511 YPGEPFI 517


>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
            precursor [Homo sapiens]
          Length = 1304

 Score =  396 bits (1018), Expect = e-110
 Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)

Query: 1323 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 1381
            PI    L +  +R  A++   F  E++SI     +F  + +    N+ KNRY +++ YD+
Sbjct: 630  PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 689

Query: 1382 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1441
            +RV LS I G  GS+Y+NA+YIDG+++   YIA QG   ET  DFWRMIWEQ++  +VM+
Sbjct: 690  NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 749

Query: 1442 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1498
            T+ EE +R KC +YWPS   GT   G V V +        Y ++   +  K   +  REV
Sbjct: 750  TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 809

Query: 1499 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1558
               QFT+WPDHGVPE P   L   RRV   +   +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 810  THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 869

Query: 1559 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1618
             ++ E  VD+YG+V  +R QR  MVQ E QYI IH AL+E    G TEV    L+ Y+  
Sbjct: 870  GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 929

Query: 1619 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1676
            + + +     + +E EF+RL S ++  ++ I  N   NK KNR  N++PY+  RV L+  
Sbjct: 930  MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 988

Query: 1677 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1719
                                  E S YINASFI  Y + +  IA QGPL ET  DFW+M+
Sbjct: 989  LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1048

Query: 1720 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1779
            ++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR F++  +
Sbjct: 1049 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1107

Query: 1780 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1831
            +   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ +HC
Sbjct: 1108 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1167

Query: 1832 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1884
              G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T +QYQF Y
Sbjct: 1168 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1220



 Score =  197 bits (501), Expect = 8e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 1651 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1710
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 670  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 729

Query: 1711 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1768
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 730  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 789

Query: 1769 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1827
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 790  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 847

Query: 1828 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1887
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY   ++A 
Sbjct: 848  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907

Query: 1888 LEY 1890
            +EY
Sbjct: 908  VEY 910



 Score =  156 bits (395), Expect = 2e-37
 Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)

Query: 1324 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 1378
            + + EL  ++  +K  D          E++ +   + +  +H  N E NK KNR +NVI 
Sbjct: 918  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 977

Query: 1379 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1419
            YD++RV L         S  +    SD          Y+NA++I  Y K    IA QG L
Sbjct: 978  YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 1037

Query: 1420 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1479
             ET GDFW+MI++++   +VM+T+L+   +  C QYW   G +T+G ++V L DT + +T
Sbjct: 1038 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 1096

Query: 1480 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1532
            Y +R F L  +   + R V Q+Q+T W    +P  P   ++ ++ VK   P         
Sbjct: 1097 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 1156

Query: 1533 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1589
               + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V  +R  R  MV T +QY
Sbjct: 1157 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1216

Query: 1590 IFIHDALLEAVTCGNTEVPARN 1611
             F++D +       N +V   N
Sbjct: 1217 QFLYDVIASTYPAQNGQVKKNN 1238



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 22/226 (9%)

Query: 417 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 474
           + TTI ++WK  E            +T D TQ++    +  + + D++   + NL P+  
Sbjct: 315 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 362

Query: 475 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 534
           Y        +      +S I + T  G PG+P       E+    +++W PP+  +  N+
Sbjct: 363 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 420

Query: 535 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEISARTM 592
            L Y   +  E+  + ++     Y LQ LKP + Y   L A     +  + +A +   T 
Sbjct: 421 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT 478

Query: 593 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 638
           +S P +   +++ +  S  S+ V  +PP    +NG    Y ++  A
Sbjct: 479 KSAPPSQVWNMTVSMTSDNSMHVKCRPP--RDRNGPHERYHLEVEA 522



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 29/124 (23%), Positives = 50/124 (40%), Gaps = 11/124 (8%)

Query: 600 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 659
           PQ I C S ++   +++W PP     N   T   IK T  D         L +  +  KY
Sbjct: 393 PQIIFCRSEAAHQGVITWNPPQRSFHN--FTLCYIKETEKD--------CLNLDKNLIKY 442

Query: 660 LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR-TNEDVPSGPPRKVEVEAVNSTSVKVS 718
            L+ L+ +T+Y +++ A+          + +   T +  P      + V   +  S+ V 
Sbjct: 443 DLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVK 502

Query: 719 WRSP 722
            R P
Sbjct: 503 CRPP 506



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 10/127 (7%)

Query: 774 ISGLQPETSYSLTVTAYT-TKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQW 830
           +  L+P T Y L++ AY   K     S      TT + P      + ++ T  N+  ++ 
Sbjct: 444 LQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKC 503

Query: 831 HPPVDTFGPLQGYRLKFGRKDMEPLTTL--EFSEKEDHFTATDIHKGASYVFRLSARNKV 888
            PP D  GP + Y L     ++E   TL    S K   F   D+     Y F+    N  
Sbjct: 504 RPPRDRNGPHERYHL-----EVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGD 558

Query: 889 GFGEEMV 895
             GE  +
Sbjct: 559 YPGEPFI 565


>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
            precursor [Homo sapiens]
          Length = 1143

 Score =  396 bits (1018), Expect = e-110
 Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)

Query: 1323 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 1381
            PI    L +  +R  A++   F  E++SI     +F  + +    N+ KNRY +++ YD+
Sbjct: 469  PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 528

Query: 1382 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1441
            +RV LS I G  GS+Y+NA+YIDG+++   YIA QG   ET  DFWRMIWEQ++  +VM+
Sbjct: 529  NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 588

Query: 1442 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1498
            T+ EE +R KC +YWPS   GT   G V V +        Y ++   +  K   +  REV
Sbjct: 589  TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 648

Query: 1499 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1558
               QFT+WPDHGVPE P   L   RRV   +   +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 649  THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 708

Query: 1559 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1618
             ++ E  VD+YG+V  +R QR  MVQ E QYI IH AL+E    G TEV    L+ Y+  
Sbjct: 709  GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 768

Query: 1619 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1676
            + + +     + +E EF+RL S ++  ++ I  N   NK KNR  N++PY+  RV L+  
Sbjct: 769  MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 827

Query: 1677 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1719
                                  E S YINASFI  Y + +  IA QGPL ET  DFW+M+
Sbjct: 828  LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 887

Query: 1720 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1779
            ++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR F++  +
Sbjct: 888  FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 946

Query: 1780 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1831
            +   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ +HC
Sbjct: 947  KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1006

Query: 1832 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1884
              G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T +QYQF Y
Sbjct: 1007 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059



 Score =  197 bits (501), Expect = 8e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 1651 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1710
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 509  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568

Query: 1711 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1768
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 569  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628

Query: 1769 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1827
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 629  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686

Query: 1828 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1887
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY   ++A 
Sbjct: 687  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746

Query: 1888 LEY 1890
            +EY
Sbjct: 747  VEY 749



 Score =  156 bits (395), Expect = 2e-37
 Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)

Query: 1324 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 1378
            + + EL  ++  +K  D          E++ +   + +  +H  N E NK KNR +NVI 
Sbjct: 757  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 816

Query: 1379 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1419
            YD++RV L         S  +    SD          Y+NA++I  Y K    IA QG L
Sbjct: 817  YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 876

Query: 1420 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1479
             ET GDFW+MI++++   +VM+T+L+   +  C QYW   G +T+G ++V L DT + +T
Sbjct: 877  KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 935

Query: 1480 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1532
            Y +R F L  +   + R V Q+Q+T W    +P  P   ++ ++ VK   P         
Sbjct: 936  YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 995

Query: 1533 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1589
               + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V  +R  R  MV T +QY
Sbjct: 996  HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1055

Query: 1590 IFIHDALLEAVTCGNTEVPARN 1611
             F++D +       N +V   N
Sbjct: 1056 QFLYDVIASTYPAQNGQVKKNN 1077



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 22/226 (9%)

Query: 417 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 474
           + TTI ++WK  E            +T D TQ++    +  + + D++   + NL P+  
Sbjct: 154 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 201

Query: 475 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 534
           Y        +      +S I + T  G PG+P       E+    +++W PP+  +  N+
Sbjct: 202 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 259

Query: 535 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEISARTM 592
            L Y   +  E+  + ++     Y LQ LKP + Y   L A     +  + +A +   T 
Sbjct: 260 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT 317

Query: 593 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 638
           +S P +   +++ +  S  S+ V  +PP    +NG    Y ++  A
Sbjct: 318 KSAPPSQVWNMTVSMTSDNSMHVKCRPP--RDRNGPHERYHLEVEA 361



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 29/124 (23%), Positives = 50/124 (40%), Gaps = 11/124 (8%)

Query: 600 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 659
           PQ I C S ++   +++W PP     N   T   IK T  D         L +  +  KY
Sbjct: 232 PQIIFCRSEAAHQGVITWNPPQRSFHN--FTLCYIKETEKD--------CLNLDKNLIKY 281

Query: 660 LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR-TNEDVPSGPPRKVEVEAVNSTSVKVS 718
            L+ L+ +T+Y +++ A+          + +   T +  P      + V   +  S+ V 
Sbjct: 282 DLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVK 341

Query: 719 WRSP 722
            R P
Sbjct: 342 CRPP 345



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 10/127 (7%)

Query: 774 ISGLQPETSYSLTVTAYT-TKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQW 830
           +  L+P T Y L++ AY   K     S      TT + P      + ++ T  N+  ++ 
Sbjct: 283 LQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKC 342

Query: 831 HPPVDTFGPLQGYRLKFGRKDMEPLTTL--EFSEKEDHFTATDIHKGASYVFRLSARNKV 888
            PP D  GP + Y L     ++E   TL    S K   F   D+     Y F+    N  
Sbjct: 343 RPPRDRNGPHERYHL-----EVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGD 397

Query: 889 GFGEEMV 895
             GE  +
Sbjct: 398 YPGEPFI 404


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.133    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,108,556
Number of Sequences: 37866
Number of extensions: 3800900
Number of successful extensions: 22336
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 323
Number of HSP's successfully gapped in prelim test: 221
Number of HSP's that attempted gapping in prelim test: 9360
Number of HSP's gapped (non-prelim): 4119
length of query: 1899
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1782
effective length of database: 13,817,196
effective search space: 24622243272
effective search space used: 24622243272
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.