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Search of human proteins with 188497703
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|188497703 semaphorin 3F [Homo sapiens]
(785 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|188497703 semaphorin 3F [Homo sapiens] 1634 0.0
gi|5454048 semaphorin 3C [Homo sapiens] 821 0.0
gi|5174673 semaphorin 3A precursor [Homo sapiens] 736 0.0
gi|41406086 semaphorin 3D [Homo sapiens] 697 0.0
gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens] 677 0.0
gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens] 672 0.0
gi|6912650 semaphorin 3E [Homo sapiens] 663 0.0
gi|9910362 semaphorin sem2 [Homo sapiens] 623 e-178
gi|157388902 semaphorin 4C [Homo sapiens] 313 5e-85
gi|214010218 semaphorin 4D isoform 1 [Homo sapiens] 312 7e-85
gi|28872814 semaphorin 4G [Homo sapiens] 299 8e-81
gi|214010220 semaphorin 4D isoform 2 [Homo sapiens] 299 8e-81
gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens] 294 2e-79
gi|39777610 semaphorin 4B precursor [Homo sapiens] 294 2e-79
gi|39777608 semaphorin 4B precursor [Homo sapiens] 294 2e-79
gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens] 294 2e-79
gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens] 294 2e-79
gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens] 294 2e-79
gi|21361914 semaphorin B [Homo sapiens] 291 2e-78
gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens] 288 1e-77
gi|11991660 sema domain, transmembrane domain (TM), and cytoplas... 269 8e-72
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 261 2e-69
gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens] 254 2e-67
gi|19923279 semaphorin W [Homo sapiens] 252 8e-67
gi|16306552 semaphorin Y [Homo sapiens] 241 2e-63
gi|147904700 semaphorin 5A [Homo sapiens] 238 2e-62
gi|19718780 semaphorin 6B precursor [Homo sapiens] 237 4e-62
gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens] 197 3e-50
gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens] 197 4e-50
gi|225637524 semaphorin 7A isoform 3 [Homo sapiens] 194 2e-49
>gi|188497703 semaphorin 3F [Homo sapiens]
Length = 785
Score = 1634 bits (4231), Expect = 0.0
Identities = 785/785 (100%), Positives = 785/785 (100%)
Query: 1 MLVAGLLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRIL 60
MLVAGLLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRIL
Sbjct: 1 MLVAGLLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRIL 60
Query: 61 LKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVR 120
LKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVR
Sbjct: 61 LKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVR 120
Query: 121 LIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTA 180
LIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTA
Sbjct: 121 LIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTA 180
Query: 181 PRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQ 240
PRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQ
Sbjct: 181 PRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQ 240
Query: 241 TAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQSPAVYARIGRIC 300
TAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQSPAVYARIGRIC
Sbjct: 241 TAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQSPAVYARIGRIC 300
Query: 301 LNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFT 360
LNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFT
Sbjct: 301 LNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFT 360
Query: 361 SSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPS 420
SSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPS
Sbjct: 361 SSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPS 420
Query: 421 MKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYEV 480
MKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYEV
Sbjct: 421 MKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYEV 480
Query: 481 LFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGV 540
LFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGV
Sbjct: 481 LFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGV 540
Query: 541 THLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRG 600
THLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRG
Sbjct: 541 THLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRG 600
Query: 601 FNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDRFLRTE 660
FNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDRFLRTE
Sbjct: 601 FNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDRFLRTE 660
Query: 661 QGLLLRALQLSDRGLYSCTATENNFKHVVTRVQLHVLGRDAVHAALFPPLSMSAPPPPGA 720
QGLLLRALQLSDRGLYSCTATENNFKHVVTRVQLHVLGRDAVHAALFPPLSMSAPPPPGA
Sbjct: 661 QGLLLRALQLSDRGLYSCTATENNFKHVVTRVQLHVLGRDAVHAALFPPLSMSAPPPPGA 720
Query: 721 GPPTPPYQELAQLLAQPEVGLIHQYCQGYWRHVPPSPREAPGAPRSPEPQDQKKPRNRRH 780
GPPTPPYQELAQLLAQPEVGLIHQYCQGYWRHVPPSPREAPGAPRSPEPQDQKKPRNRRH
Sbjct: 721 GPPTPPYQELAQLLAQPEVGLIHQYCQGYWRHVPPSPREAPGAPRSPEPQDQKKPRNRRH 780
Query: 781 HPPDT 785
HPPDT
Sbjct: 781 HPPDT 785
>gi|5454048 semaphorin 3C [Homo sapiens]
Length = 751
Score = 821 bits (2120), Expect = 0.0
Identities = 397/759 (52%), Positives = 544/759 (71%), Gaps = 39/759 (5%)
Query: 31 RVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPL 90
RV L+F EL+ T T+ +F+ + DYRILL DED DR+YVGSKD++LSL++++I++E L
Sbjct: 28 RVYLTFDELRETKTSEYFSLSHHPLDYRILLMDEDQDRIYVGSKDHILSLNINNISQEAL 87
Query: 91 IIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRR 150
+ W AS ++EEC ++GKD CGNFVR+IQ +NRTHLYVCG+GA++P+CTY+NRGRR
Sbjct: 88 SVFWPASTIKVEECKMAGKDPTHGCGNFVRVIQTFNRTHLYVCGSGAFSPVCTYLNRGRR 147
Query: 151 AQATPWTQTQAVRGRGSRATDGALRPMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTA 210
++ D +F ++ + ESGKG+C ++P ++T
Sbjct: 148 SE-------------------------------DQVFMID-SKCESGKGRCSFNPNVNTV 175
Query: 211 SALINEELYAGVYIDFMGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAER 270
S +INEEL++G+YIDFMGTDAAIFR+L K+ A+RTDQ+NS+WL++P F+ A +IPD +
Sbjct: 176 SVMINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPMFVDAHVIPDGTDP 235
Query: 271 NDDKLYFFFRERSAEAPQSPA-VYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGE 329
ND K+YFFF+E+ + +S +++ I RIC ND GG LVNKW+TFLKARLVCSV E
Sbjct: 236 NDAKVYFFFKEKLTDNNRSTKQIHSMIARICPNDTGGLRSLVNKWTTFLKARLVCSVTDE 295
Query: 330 DGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAH 389
DG ETHFDEL+DVF+ +T + R ++Y +FT+S SVF+GSAVCVY ++DI+ VFNGPFAH
Sbjct: 296 DGPETHFDELEDVFLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHLSDIQTVFNGPFAH 355
Query: 390 KEGPNYQWMPFSGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQ 449
KEGPN+Q + + G++PYPRPGTCPGG FTP+M++TK++PD+V+ F+R+HPLMY ++YP+
Sbjct: 356 KEGPNHQLISYQGRIPYPRPGTCPGGAFTPNMRTTKEFPDDVVTFIRNHPLMYNSIYPIH 415
Query: 450 RRPLVVRTGAPYRLTTIAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQELEELMLE 509
+RPL+VR G Y+ T IAVD+V+AADGRY VLFLGTDRGTVQKV+VLP ++ EL+LE
Sbjct: 416 KRPLIVRIGTDYKYTKIAVDRVNAADGRYHVLFLGTDRGTVQKVVVLPTNNSVSGELILE 475
Query: 510 EVEVFKDPAPVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWD 569
E+EVFK+ AP+ TM ISSK+QQLYV+S GV+ +SLHRC YG ACADCCLARDPYCAWD
Sbjct: 476 ELEVFKNHAPITTMKISSKKQQLYVSSNEGVSQVSLHRCHIYGTACADCCLARDPYCAWD 535
Query: 570 GQACSRYTASSKRRSRRQDVRHGNPIRQCRGFNSNANKNAVESVQYGVAGSAAFLECQPR 629
G +CSR+ + KRRSRRQDVRHGNP+ QCRGFN A +NA E VQYGV + FLEC P+
Sbjct: 536 GHSCSRFYPTGKRRSRRQDVRHGNPLTQCRGFNLKAYRNAAEIVQYGVKNNTTFLECAPK 595
Query: 630 SPQATVKWLFQRDPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLYSCTATENNFKHVV 689
SPQA++KWL Q+D DRR+E++ +R + T QGLL+R++Q SD+GLY C ATEN+FK +
Sbjct: 596 SPQASIKWLLQKDK-DRRKEVKLNERIIATSQGLLIRSVQGSDQGLYHCIATENSFKQTI 654
Query: 690 TRVQLHVLGRDAVHAALFPPLSMSAPPPPGAGPPTPPYQELAQLLAQPEVGLIHQYCQG- 748
++ VL + V + A P P +++ + E+ +I+QYC+
Sbjct: 655 AKINFKVLDSEMVAVVTDKWSPWTWASSVRALPFHP--KDIMGAFSHSEMQMINQYCKDT 712
Query: 749 --YWRHVPPSPREAPGAPRSPEPQDQKKPRNRRHHPPDT 785
+ S + + + +K RNRR+ P++
Sbjct: 713 RQQHQQGDESQKMRGDYGKLKALINSRKSRNRRNQLPES 751
>gi|5174673 semaphorin 3A precursor [Homo sapiens]
Length = 771
Score = 736 bits (1901), Expect = 0.0
Identities = 369/789 (46%), Positives = 502/789 (63%), Gaps = 50/789 (6%)
Query: 7 LLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDH 66
L W LLT Q+ PR++LS+KE+ + FN L N++ Y L DE+
Sbjct: 10 LFWGVLLTAR---ANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEER 66
Query: 67 DRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWN 126
R+YVG+KD++ S DL +I I+ W S R +EC +GKD+ EC NF+++++ +N
Sbjct: 67 SRLYVGAKDHIFSFDLVNIKDFQKIV-WPVSYTRRDECKWAGKDILKECANFIKVLKAYN 125
Query: 127 RTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQDYI 186
+THLY CGTGA++P+CTY+ G + D I
Sbjct: 126 QTHLYACGTGAFHPICTYIEIGHHPE-------------------------------DNI 154
Query: 187 FYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAMRTD 246
F LE E+G+GK PYDPKL TAS LI+ ELY+G DFMG D AIFRTLG +RT+
Sbjct: 155 FKLENSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTE 214
Query: 247 QYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQS-PAVYARIGRICLNDDG 305
Q++SRWLNDP FI A LI +S DDK+YFFFRE + + S A +ARIG+IC ND G
Sbjct: 215 QHDSRWLNDPKFISAHLISESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFG 274
Query: 306 GHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSV 365
GH LVNKW+TFLKARL+CSVPG +GI+THFDELQDVF+ +D +NPV+Y VFT+S ++
Sbjct: 275 GHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNI 334
Query: 366 FRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPSMKSTK 425
F+GSAVC+YSM+D+R VF GP+AH++GPNYQW+P+ G++PYPRPGTCP TF STK
Sbjct: 335 FKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTF-GGFDSTK 393
Query: 426 DYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYEVLFLGT 485
D PD+VI F RSHP MY V+P+ RP+V++T Y+ T I VD+VDA DG+Y+V+F+GT
Sbjct: 394 DLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGT 453
Query: 486 DRGTVQKVIVLPKDD-QELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGVTHLS 544
D GTV KV+ +PK+ +LEE++LEE+ VF++P + M +S+K+QQLY+ S GV L
Sbjct: 454 DVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTKQQQLYIGSTAGVAQLP 513
Query: 545 LHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRGF--N 602
LHRC YG ACA+CCLARDPYCAWDG ACSRY ++KRR+RRQD+R+G+P+ C +
Sbjct: 514 LHRCDIYGKACAECCLARDPYCAWDGSACSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHD 573
Query: 603 SNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDRFLRTEQG 662
++ + E + YGV S+ FLEC P+S +A V W FQR +R+ EIR +D +RT+QG
Sbjct: 574 NHHGHSPEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEERKEEIRVDDHIIRTDQG 633
Query: 663 LLLRALQLSDRGLYSCTATENNFKHVVTRVQLHVLGRDAVHAALFPPLSMSAPPPPGAGP 722
LLLR+LQ D G Y C A E+ F + +V L V+ + + L
Sbjct: 634 LLLRSLQQKDSGNYLCHAVEHGFIQTLLKVTLEVIDTEHLEELLHKDDDGDGSKTKEMSN 693
Query: 723 PTPP-----YQELAQLLAQPEVGLIHQYCQGYWRHVPPSPREAPG-----APRSPEPQDQ 772
P Y++ QL+ P + + ++C+ W+ R+ PG + + Q+
Sbjct: 694 SMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHTPGNSNKWKHLQEN 753
Query: 773 KKPRNRRHH 781
KK RNRR H
Sbjct: 754 KKGRNRRTH 762
>gi|41406086 semaphorin 3D [Homo sapiens]
Length = 777
Score = 697 bits (1798), Expect = 0.0
Identities = 343/762 (45%), Positives = 490/762 (64%), Gaps = 49/762 (6%)
Query: 30 PRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINREP 89
PR++L++K+L + + F D++ LL DE+ R+ +G+KD++ L L D+N+
Sbjct: 43 PRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNF 102
Query: 90 LIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGR 149
I+W A+ +R+E C L+GKD N EC NF+R++QP+N+TH+YVCGTGA++P+C Y++ G
Sbjct: 103 KKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLG- 161
Query: 150 RAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDT 209
++D IF L+ LESG+ KCP+DP+
Sbjct: 162 ------------------------------VYKEDIIFKLDTHNLESGRLKCPFDPQQPF 191
Query: 210 ASALINEELYAGVYIDFMGTDAAIFRTLG---KQTAMRTDQYNSRWLNDPSFIHAELIPD 266
AS + +E LY+G DF+G D A R+LG +RTD WLN FI IPD
Sbjct: 192 ASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPD 251
Query: 267 SAERNDDKLYFFFRERSAEAPQS-PAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCS 325
+ +DDK+YFFFRE S E S + +R+GR+C ND GG L+NKW+TFLKARL+CS
Sbjct: 252 TYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLKARLICS 311
Query: 326 VPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNG 385
+PG DG +T+FDELQD+++ T+D RNPV+Y VFT++ S+F+GSAVCVYSMADIR VFNG
Sbjct: 312 IPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNG 371
Query: 386 PFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAV 445
P+AHKE +++W+ + G++PYPRPGTCP T+ P +KST+D+PD+VI+F++ H +MY++V
Sbjct: 372 PYAHKESADHRWVQYDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFIKRHSVMYKSV 431
Query: 446 YPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQELEE 505
YP+ P R YRLT I VD V A DG+Y+V+FLGTD GTV KV+ + K+ +EE
Sbjct: 432 YPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQYDVMFLGTDIGTVLKVVSISKEKWNMEE 491
Query: 506 LMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPY 565
++LEE+++FK + + M +S K+QQLY+ S G+ LSLHRC YG ACADCCLARDPY
Sbjct: 492 VVLEELQIFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKACADCCLARDPY 551
Query: 566 CAWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRGF-NSNANKNAVESVQYGVAGSAAFL 624
CAWDG ACSRY +SKRR+RRQDV++G+PI QC +S +++ A E V +G+ ++ FL
Sbjct: 552 CAWDGNACSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHETADEKVIFGIEFNSTFL 611
Query: 625 ECQPRSPQATVKWLFQRDPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLYSCTATENN 684
EC P+S QAT+KW QR + R E++ ++R ++TE GLL+R+LQ D G+Y C A E+
Sbjct: 612 ECIPKSQQATIKWYIQRSGDEHREELKPDERIIKTEYGLLIRSLQKKDSGMYYCKAQEHT 671
Query: 685 FKHVVTRVQLHVLGRDAVHAALFPPLSMSAPPPPG-----AGPPTPPYQELAQLLAQPEV 739
F H + ++ L+V+ + + + A G Y++ Q+L+ P
Sbjct: 672 FIHTIVKLTLNVIENEQMEN------TQRAEHEEGKVKDLLAESRLRYKDYIQILSSPNF 725
Query: 740 GLIHQYCQGYWRHVPPSPREAPGAPRSPEPQDQKKPRNRRHH 781
L QYC+ W H + G P+ Q+ KK RNRRHH
Sbjct: 726 SL-DQYCEQMW-HREKRRQRNKGGPKWKHMQEMKKKRNRRHH 765
>gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]
Length = 749
Score = 677 bits (1747), Expect = 0.0
Identities = 374/791 (47%), Positives = 498/791 (62%), Gaps = 71/791 (8%)
Query: 2 LVAGL-LLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRIL 60
++ GL LLWA L A PS PR+RLSF+EL+A F+ L T Y+ L
Sbjct: 9 VIPGLALLWAVGLGSAAPS---------PPRLRLSFQELQAWHGLQTFS-LERTCCYQAL 58
Query: 61 LKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVR 120
L DE+ R++VG++++V SL+L +I++ + W A + EEC +GKD+ EC NFV+
Sbjct: 59 LVDEERGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVK 118
Query: 121 LIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTA 180
L+ +NRTHL CGTGA++P C +V G RA+
Sbjct: 119 LLHAYNRTHLLACGTGAFHPTCAFVEVGHRAE---------------------------- 150
Query: 181 PRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQ 240
+ + L+P R+E GKGK PYDP+ AS L+ EELY+GV D MG D IFR+LG++
Sbjct: 151 ---EPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGVAADLMGRDFTIFRSLGQR 207
Query: 241 TAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQSPAV----YARI 296
++RT+ ++SRWLN+P F+ IP+S +DDK+YFFFRE + EA +PA+ +R+
Sbjct: 208 PSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRETAVEA--APALGRLSVSRV 265
Query: 297 GRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIY 356
G+IC ND GG LVNKW+TFLKARLVCSVPG +G +THFD+LQDVF+ ++D R P++Y
Sbjct: 266 GQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG-DTHFDQLQDVFLLSSRDHRTPLLY 324
Query: 357 AVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGT 416
AVF++S S+F+GSAVCVYSM D+R F GPFAHKEGP +QW+ + G++PYPRPG CP T
Sbjct: 325 AVFSTSSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKT 384
Query: 417 FTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADG 476
F + STKD+PD+VI F R+HPLMY +V P RPL ++ GA Y T IA D+V AADG
Sbjct: 385 FG-TFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVAAADG 443
Query: 477 RYEVLFLGTDRGTVQKVIVLPKDDQ-ELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVA 535
Y+VLF+GTD GTV KVI +PK + E L+LEE+ VF+D A V +M ISSKR QLYVA
Sbjct: 444 HYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFEDSAAVTSMQISSKRHQLYVA 503
Query: 536 SAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPI 595
S V ++LHRC A+G C +CCLARDPYCAWDG AC+R+ S+KRR RRQDVR+G+P
Sbjct: 504 SRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVACTRFQPSAKRRFRRQDVRNGDPS 563
Query: 596 RQCRGFNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDR 655
C G ++ +E +GV GS+AFLEC+PRS QA V+W FQR ++ AE+R
Sbjct: 564 TLCSG--DSSRPALLEHKVFGVEGSSAFLECEPRSLQARVEWTFQRAGVTAHTQVLAEER 621
Query: 656 FLRTEQGLLLRALQLSDRGLYSCTATENNFKHVVTRVQLHVLGRDAVHAALFPPLSMSAP 715
RT +GLLLR L+ D G+Y C A E F + R+ LHVL A A +AP
Sbjct: 622 TERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRRLSLHVL--SATQAERLARAEEAAP 679
Query: 716 PPPGAGPPTPP--YQELAQLLAQPEVGLIHQYCQGYWRHVPPSPREAPGAPRSPEPQDQK 773
A PP P Y++ QL+ G + R P P A +S + ++
Sbjct: 680 ----AAPPGPKLWYRDFLQLVEPGGGGSANSL-----RMCRPQP-----ALQSLPLESRR 725
Query: 774 KPRNRRHHPPD 784
K RNRR H P+
Sbjct: 726 KGRNRRTHAPE 736
>gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]
Length = 748
Score = 672 bits (1735), Expect = 0.0
Identities = 374/791 (47%), Positives = 498/791 (62%), Gaps = 72/791 (9%)
Query: 2 LVAGL-LLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRIL 60
++ GL LLWA L A PS PR+RLSF+EL+A F+ L T Y+ L
Sbjct: 9 VIPGLALLWAVGLGSAAPS---------PPRLRLSFQELQAWHGLQTFS-LERTCCYQAL 58
Query: 61 LKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVR 120
L DE+ R++VG++++V SL+L +I++ + W A + EEC +GKD+ EC NFV+
Sbjct: 59 LVDEERGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVK 118
Query: 121 LIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTA 180
L+ +NRTHL CGTGA++P C +V G RA+
Sbjct: 119 LLHAYNRTHLLACGTGAFHPTCAFVEVGHRAE---------------------------- 150
Query: 181 PRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQ 240
+ + L+P R+E GKGK PYDP+ AS L+ EELY+GV D MG D IFR+LG++
Sbjct: 151 ---EPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGVAADLMGRDFTIFRSLGQR 207
Query: 241 TAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQSPAV----YARI 296
++RT+ ++SRWLN+P F+ IP+S +DDK+YFFFRE + EA +PA+ +R+
Sbjct: 208 PSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRETAVEA--APALGRLSVSRV 265
Query: 297 GRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIY 356
G+IC ND GG LVNKW+TFLKARLVCSVPG +G +THFD+LQDVF+ ++D R P++Y
Sbjct: 266 GQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG-DTHFDQLQDVFLLSSRDHRTPLLY 324
Query: 357 AVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGT 416
AVF++S S+F+GSAVCVYSM D+R F GPFAHKEGP +QW+ + G++PYPRPG CP T
Sbjct: 325 AVFSTS-SIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKT 383
Query: 417 FTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADG 476
F + STKD+PD+VI F R+HPLMY +V P RPL ++ GA Y T IA D+V AADG
Sbjct: 384 FG-TFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVAAADG 442
Query: 477 RYEVLFLGTDRGTVQKVIVLPKDDQ-ELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVA 535
Y+VLF+GTD GTV KVI +PK + E L+LEE+ VF+D A V +M ISSKR QLYVA
Sbjct: 443 HYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFEDSAAVTSMQISSKRHQLYVA 502
Query: 536 SAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPI 595
S V ++LHRC A+G C +CCLARDPYCAWDG AC+R+ S+KRR RRQDVR+G+P
Sbjct: 503 SRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVACTRFQPSAKRRFRRQDVRNGDPS 562
Query: 596 RQCRGFNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDR 655
C G ++ +E +GV GS+AFLEC+PRS QA V+W FQR ++ AE+R
Sbjct: 563 TLCSG--DSSRPALLEHKVFGVEGSSAFLECEPRSLQARVEWTFQRAGVTAHTQVLAEER 620
Query: 656 FLRTEQGLLLRALQLSDRGLYSCTATENNFKHVVTRVQLHVLGRDAVHAALFPPLSMSAP 715
RT +GLLLR L+ D G+Y C A E F + R+ LHVL A A +AP
Sbjct: 621 TERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRRLSLHVL--SATQAERLARAEEAAP 678
Query: 716 PPPGAGPPTPP--YQELAQLLAQPEVGLIHQYCQGYWRHVPPSPREAPGAPRSPEPQDQK 773
A PP P Y++ QL+ G + R P P A +S + ++
Sbjct: 679 ----AAPPGPKLWYRDFLQLVEPGGGGSANSL-----RMCRPQP-----ALQSLPLESRR 724
Query: 774 KPRNRRHHPPD 784
K RNRR H P+
Sbjct: 725 KGRNRRTHAPE 735
>gi|6912650 semaphorin 3E [Homo sapiens]
Length = 775
Score = 663 bits (1710), Expect = 0.0
Identities = 344/795 (43%), Positives = 478/795 (60%), Gaps = 58/795 (7%)
Query: 6 LLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDED 65
LLLW LL W T D PR+RLS KEL F+ D +L DE
Sbjct: 10 LLLWGYLLE-LWTGGHTAD--TTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEY 66
Query: 66 HDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPW 125
+R++VG +D V SL L I+ IHW ++ ++EEC++ GKD GEC N+VR++ +
Sbjct: 67 QERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDA-GECANYVRVLHHY 125
Query: 126 NRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQDY 185
NRTHL CGTGA++P+C ++ G +D
Sbjct: 126 NRTHLLTCGTGAFDPVCAFIRVGYHL-------------------------------EDP 154
Query: 186 IFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAMRT 245
+F+LE R E G+G+CP+DP S LI EL+AG+Y D+ DAAIFR++G+ +RT
Sbjct: 155 LFHLESPRSERGRGRCPFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRLAHIRT 214
Query: 246 DQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQSP-AVYARIGRICLNDD 304
+ + R L +P F+ + +IPD+ +R+D+K+YFFF E++ EA + A+Y R+GR+C+ND
Sbjct: 215 EHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDV 274
Query: 305 GGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGS 364
GG LVNKWSTFLKARLVCSVPG +GI+T+FDEL+DVF+ T+D +NPVI+ +F ++ +
Sbjct: 275 GGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIFGLFNTTSN 334
Query: 365 VFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPSMKST 424
+FRG A+CVY M+ IR FNGP+AHKEGP Y W + GK+PYPRPG+C +T
Sbjct: 335 IFRGHAICVYHMSSIRAAFNGPYAHKEGPEYHWSVYEGKVPYPRPGSCASKVNGGRYGTT 394
Query: 425 KDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYEVLFLG 484
KDYPD+ I F RSHPLMYQA+ P ++P++V+T Y L IAVD+V+A DG+Y+VLF+G
Sbjct: 395 KDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQYDVLFIG 454
Query: 485 TDRGTVQKVIVLPKDDQE-LEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGVTHL 543
TD G V KVI + + E +EE++LEE+++FKDP P+ +M ISSKRQQLY+ SA V +
Sbjct: 455 TDNGIVLKVITIYNQEMESMEEVILEELQIFKDPVPIISMEISSKRQQLYIGSASAVAQV 514
Query: 544 SLHRCQAYGAACADCCLARDPYCAWDGQACSRYTAS---SKRRSRRQDVRHGNPIRQCRG 600
H C YG+ACADCCLARDPYCAWDG +CSRY + +KRR RRQDVRHGN +QC G
Sbjct: 515 RFHHCDMYGSACADCCLARDPYCAWDGISCSRYYPTGTHAKRRFRRQDVRHGNAAQQCFG 574
Query: 601 --FNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDRFLR 658
F +A E + YG+ ++ LEC PRS QA V W Q+ R+ E++ +DR ++
Sbjct: 575 QQFVGDALDKTEEHLAYGIENNSTLLECTPRSLQAKVIWFVQKGRETRKEEVKTDDRVVK 634
Query: 659 TEQGLLLRALQLSDRGLYSCTATENNFKHVVTRVQLHVLGRDAVHAALFP---------- 708
+ GLL L SD G Y C E++F H V ++ L V+ + V
Sbjct: 635 MDLGLLFLRLHKSDAGTYFCQTVEHSFVHTVRKITLEVVEEEKVEDMFNKDDEEDRHHRM 694
Query: 709 PLSMSAPPPPGAGPPTPPYQELAQLLAQPEVGLIHQYCQGYW--RHVPPSPREAPGAPRS 766
P + GA P Y+E QL+ + +YC+ W + +P +
Sbjct: 695 PCPAQSSISQGA---KPWYKEFLQLIGYSNFQRVEEYCEKVWCTDRKRKKLKMSPSKWKY 751
Query: 767 PEPQDQKKPRNRRHH 781
PQ +KK R++ H
Sbjct: 752 ANPQ-EKKLRSKPEH 765
>gi|9910362 semaphorin sem2 [Homo sapiens]
Length = 782
Score = 623 bits (1607), Expect = e-178
Identities = 325/737 (44%), Positives = 450/737 (61%), Gaps = 47/737 (6%)
Query: 27 PATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDIN 86
P+ PR+RLS+++L + + F + + + + DE DR+++G D + SL L
Sbjct: 28 PSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAW 87
Query: 87 REPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVN 146
+P + W P + EECV G+D EC NFVR++QP NRTHL CGTGA+ P C +
Sbjct: 88 PDPREVLWPPQPGQREECVRKGRDPLTECANFVRVLQPHNRTHLLACGTGAFQPTCALIT 147
Query: 147 RGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQDYIFYLEPERLESGKGKCPYDPK 206
G R + ++ +LEP +ESG+G+CP++P
Sbjct: 148 VGHRGE--------------------------------HVLHLEPGSVESGRGRCPHEPS 175
Query: 207 LDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPD 266
AS I+ ELY G+ DF+G +A IFR+ G + A+R+D S L+DP F+ A IP+
Sbjct: 176 RPFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSL-LHDPRFVMAARIPE 234
Query: 267 SAERNDDKLYFFFRER--SAEAPQSPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVC 324
++++++DK+YFFF E S + + +R+GR+C+ND GG LVNKWSTFLKARLVC
Sbjct: 235 NSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVC 294
Query: 325 SVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFN 384
SVPG G ETHFD+L+DVF+ + ++ +YA+F++ +VF+G AVCVY MADI VFN
Sbjct: 295 SVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFN 354
Query: 385 GPFAHKEGPNYQWMPFSGKMPYPRPGTCPGG-TFTPS--MKSTKDYPDEVINFMRSHPLM 441
GPFAH++GP +QW P+ GK+P+PRPG CP T P STKDYPDEV+ F R+HPLM
Sbjct: 355 GPFAHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLM 414
Query: 442 YQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPK-DD 500
+ V P RP++V+T +L I VD+V+A DG Y+V+FLGTD G+V KVI L
Sbjct: 415 FWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGTYDVIFLGTDSGSVLKVIALQAGGS 474
Query: 501 QELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCL 560
E EE++LEE++VFK P P+ M IS KRQ LYV S +GV L LH+C+ YG ACA+CCL
Sbjct: 475 AEPEEVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCL 534
Query: 561 ARDPYCAWDGQACSRYTAS-SKRRSRRQDVRHGNPIRQCRGFN--SNANKNAVESVQYGV 617
ARDPYCAWDG +C+ Y S KRR RRQD+RHGNP QC G + A ++ YG
Sbjct: 535 ARDPYCAWDGASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGT 594
Query: 618 AGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLYS 677
++ FLEC P+SPQA V+WL QR + +++ ++R L TE+GLL R L D G Y+
Sbjct: 595 EHNSTFLECLPKSPQAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYT 654
Query: 678 CTATENNFKHVVTRVQLHVLGRDAVHAALFPPLSMSAPPPPGAG----PPTPPYQELAQL 733
CT E+ F V R+ L V+ + LFPP PP G PP Y+++ QL
Sbjct: 655 CTTLEHGFSQTVVRLALVVIVASQLD-NLFPPEPKPEEPPARGGLASTPPKAWYKDILQL 713
Query: 734 LAQPEVGLIHQYCQGYW 750
+ + + +YC+ W
Sbjct: 714 IGFANLPRVDEYCERVW 730
>gi|157388902 semaphorin 4C [Homo sapiens]
Length = 833
Score = 313 bits (801), Expect = 5e-85
Identities = 207/637 (32%), Positives = 305/637 (47%), Gaps = 67/637 (10%)
Query: 56 DYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGEC 115
D+ L E +YVG+++ + + + + + I W A ++ EC+ GK+ EC
Sbjct: 52 DFLTLTLTEPTGLLYVGAREALFAFSMEALELQGAI-SWEAPVEKKTECIQKGKNNQTEC 110
Query: 116 GNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALR 175
NF+R +QP+N +HLYVCGT A+ P CTYVN
Sbjct: 111 FNFIRFLQPYNASHLYVCGTYAFQPKCTYVNM---------------------------- 142
Query: 176 PMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFR 235
F LE E GKGKCPYDP A L++ ELY+ +F+GT+ I R
Sbjct: 143 ---------LTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILR 193
Query: 236 TLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSA---ERNDDKLYFFFRERSAEAP-QSPA 291
+G +M+T +Y + WLN+P F+ + +P+S +DDK+YFFFRER+ E+ +
Sbjct: 194 NMGPHHSMKT-EYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQ 252
Query: 292 VYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVR 351
V AR+ R+C D GG L KW+TFLKARL CS P + +F++LQ + Q
Sbjct: 253 VVARVARVCKGDMGGARTLQRKWTTFLKARLACSAP---NWQLYFNQLQAMHTLQDTSWH 309
Query: 352 NPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGT 411
N + VF + SA+C Y + +I+ VF GP+ +W ++ +P PRPG+
Sbjct: 310 NTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGS 369
Query: 412 CPGGTF-TPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQ 470
C S+ + PD ++NF++ HPLM + V P RPL+V+ G + T + D+
Sbjct: 370 CINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNF--THLVADR 427
Query: 471 VDAADG-RYEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKR 529
V DG Y VLF+GT G + K + L +EEL L + E P++++ +S +
Sbjct: 428 VTGLDGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLFDQE------PMRSLVLSQSK 481
Query: 530 QQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRR--Q 587
+ L+ S + L + C Y +CADC LARDPYCAW SR A Q
Sbjct: 482 KLLFAGSRSQLVQLPVADCMKY-RSCADCVLARDPYCAWSVNT-SRCVAVGGHSGSLLIQ 539
Query: 588 DVRHGNPIRQCRGFNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRR 647
V + C S + +++ VAG+ L C S A +W F G R
Sbjct: 540 HVMTSDTSGICNLRGSKKVRPTPKNITV-VAGTDLVLPCHLSSNLAHARWTF----GGRD 594
Query: 648 REIRAEDRFLRTE--QGLLLRALQLSDRGLYSCTATE 682
FL Q L++ A Q G Y C + E
Sbjct: 595 LPAEQPGSFLYDARLQALVVMAAQPRHAGAYHCFSEE 631
>gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]
Length = 862
Score = 312 bits (800), Expect = 7e-85
Identities = 224/701 (31%), Positives = 343/701 (48%), Gaps = 89/701 (12%)
Query: 56 DYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGEC 115
+Y LL ED D +Y+G+++ V +++ +I+ + ++W S + +C GK EC
Sbjct: 49 NYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTEC 108
Query: 116 GNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALR 175
N++R++QP + T LYVCGT A+ P C ++N + + G
Sbjct: 109 LNYIRVLQPLSATSLYVCGTNAFQPACDHLN------------LTSFKFLGKN------- 149
Query: 176 PMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFR 235
E GKG+CP+DP S +++ ELY+G +F+G++ I R
Sbjct: 150 -------------------EDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISR 190
Query: 236 TLGKQTAMRTDQYNSRWLNDPSFIHAELI---PDSAERNDDKLYFFFRERSAEAP-QSPA 291
+ +RT+ Y WLN+PSF+ A++I PDS + DD++YFFF E S E
Sbjct: 191 N-SSHSPLRTE-YAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRV 248
Query: 292 VYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVR 351
+ RI R+C D GG L KW++FLKARL+CS P + F+ L+DVFV ++ ++
Sbjct: 249 LIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLV---FNVLRDVFVLRSPGLK 305
Query: 352 NPVIYAVFTSSGSVFRGSAVCVYSMADIRMVF-NGPFAHK---EGPNYQWMPFSGKMPYP 407
PV YA+FT + SAVC Y+++ VF +G + E + +W+ ++G +P P
Sbjct: 306 VPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKP 365
Query: 408 RPGTC-PGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTI 466
RPG C + S+ + PD+ + F++ HPLM +V P+ RP +++ Y T I
Sbjct: 366 RPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQI 423
Query: 467 AVDQVDAADGR-YEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTI 525
VD+ A DG Y+V+F+ TDRG + K I L E ++EE ++F+D PV+T+ +
Sbjct: 424 VVDRTQALDGTVYDVMFVSTDRGALHKAISL-----EHAVHIIEETQLFQDFEPVQTLLL 478
Query: 526 SSKR--QQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRR 583
SSK+ + +Y S GV L C +G C DC LARDPYCAW S TA+
Sbjct: 479 SSKKGNRFVYAGSNSGVVQAPLAFCGKHG-TCEDCVLARDPYCAW-----SPPTATCVAL 532
Query: 584 SRRQDVRHGNPIRQCRGFNSNANKNAVESVQ--YGVAGSAAFLECQPRSPQATVKWLFQR 641
+ + G I++ G S + S + + G A L+C +S A V W FQ
Sbjct: 533 HQTESPSRG-LIQEMSGDASVCPDKSKGSYRQHFFKHGGTAELKCSQKSNLARVFWKFQN 591
Query: 642 DPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLYSCTATEN-NFKHVVTRVQLHVLGRD 700
G + E + L + LL+ L D G+Y C + E K V V HVL
Sbjct: 592 --GVLKAE--SPKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVVAKHVLEVK 647
Query: 701 AVHAALFPP-------------LSMSAPPPPGAGPPTPPYQ 728
V + P + G+ PPTP Q
Sbjct: 648 VVPKPVVAPTLSVVQTEGSRIATKVLVASTQGSSPPTPAVQ 688
>gi|28872814 semaphorin 4G [Homo sapiens]
Length = 843
Score = 299 bits (765), Expect = 8e-81
Identities = 228/738 (30%), Positives = 335/738 (45%), Gaps = 101/738 (13%)
Query: 7 LLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDH 66
+L A+ + G P+++ L ATPR+ + ++EL +GT HF N Y LL +E
Sbjct: 12 ILTATAVPGPSLRRPSRE-LDATPRMTIPYEEL--SGTRHFKGQAQN---YSTLLLEEAS 65
Query: 67 DRMYVGSKDYVLSLDLHDI----NREPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLI 122
R+ VG++ + SL +DI ++E IHW ASP+ +C GK+ EC N VR +
Sbjct: 66 ARLLVGARGALFSLSANDIGDGAHKE---IHWEASPEMQSKCHQKGKNNQTECFNHVRFL 122
Query: 123 QPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPR 182
Q N THLY CGT A+ P+C A D +PT+
Sbjct: 123 QRLNSTHLYACGTHAFQPLCA-------------------------AIDAEAFTLPTS-- 155
Query: 183 QDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTA 242
E GK KCPYDP +I+ LY +F R +
Sbjct: 156 -----------FEEGKEKCPYDPARGFTGLIIDGGLYTATRYEFRSIPD--IRRSRHPHS 202
Query: 243 MRTDQYNSRWLNDPSFIHAELIPDS---AERNDDKLYFFFRERSAEA-------PQSPAV 292
+RT++ WLND F+ + L+ +S A +DDK+Y+FF ER+ E +S
Sbjct: 203 LRTEETPMHWLNDAEFVFSVLVRESKASAVGDDDKVYYFFTERATEEGSGSFTQSRSSHR 262
Query: 293 YARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRN 352
AR+ R+C D GG L KW++FLKARL+C +P ++ L+ V +
Sbjct: 263 VARVARVCKGDLGGKKILQKKWTSFLKARLICHIP-------LYETLRGVCSLDAETSSR 315
Query: 353 PVIYAVFTSSGS--VFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPG 410
YA FT S SA+C Y +A+I+ VF GP+ + + +W + G +P PRPG
Sbjct: 316 THFYAAFTLSTQWKTLEASAICRYDLAEIQAVFAGPYMEYQDGSRRWGRYEGGVPEPRPG 375
Query: 411 TCPGGTF-TPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVD 469
+C + + S++D P V++F++ HPLM + V P + RPL+++ Y T
Sbjct: 376 SCITDSLRSQGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNIRYTHLT-GTP 434
Query: 470 QVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKR 529
A Y++LFLGT G + K +VL ++EE +VF++ V+ + IS +
Sbjct: 435 VTTPAGPTYDLLFLGTADGWIHKAVVLGSGMH-----IIEETQVFRESQSVENLVISLLQ 489
Query: 530 QQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWD--GQACSRYT-----ASSKR 582
LYV + GV L L C Y +C DC LARDPYC WD AC+ T + R
Sbjct: 490 HSLYVGAPSGVIQLPLSSCSRY-RSCYDCILARDPYCGWDPGTHACAAATTIANRSQGSR 548
Query: 583 RSRRQDVRHGNPIRQCRGFNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRD 642
+ QD+ GN R C +++ + + G L C S A WL
Sbjct: 549 TALIQDIERGN--RGCESSRDTGPPPPLKT-RSVLRGDDVLLPCDQPSNLARALWLLNGS 605
Query: 643 PGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLYSCTATENNFKHVVTRVQLHVLGRDAV 702
G + + GLL+ Q G Y C A EN + ++ L V R A
Sbjct: 606 MG----LSDGQGGYRVGVDGLLVTDAQPEHSGNYGCYAEENGLRTLLASYSLTV--RPAT 659
Query: 703 HAALFPPLSMSAPPPPGA 720
P + AP PGA
Sbjct: 660 -----PAPAPKAPATPGA 672
>gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]
Length = 738
Score = 299 bits (765), Expect = 8e-81
Identities = 181/525 (34%), Positives = 281/525 (53%), Gaps = 63/525 (12%)
Query: 56 DYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGEC 115
+Y LL ED D +Y+G+++ V +++ +I+ + ++W S + +C GK EC
Sbjct: 49 NYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTEC 108
Query: 116 GNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALR 175
N++R++QP + T LYVCGT A+ P C ++N + + G
Sbjct: 109 LNYIRVLQPLSATSLYVCGTNAFQPACDHLN------------LTSFKFLGKN------- 149
Query: 176 PMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFR 235
E GKG+CP+DP S +++ ELY+G +F+G++ I R
Sbjct: 150 -------------------EDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISR 190
Query: 236 TLGKQTAMRTDQYNSRWLNDPSFIHAELI---PDSAERNDDKLYFFFRERSAEAP-QSPA 291
+ +RT+ Y WLN+PSF+ A++I PDS + DD++YFFF E S E
Sbjct: 191 N-SSHSPLRTE-YAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRV 248
Query: 292 VYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVR 351
+ RI R+C D GG L KW++FLKARL+CS P + F+ L+DVFV ++ ++
Sbjct: 249 LIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLV---FNVLRDVFVLRSPGLK 305
Query: 352 NPVIYAVFTSSGSVFRGSAVCVYSMADIRMVF-NGPFAHK---EGPNYQWMPFSGKMPYP 407
PV YA+FT + SAVC Y+++ VF +G + E + +W+ ++G +P P
Sbjct: 306 VPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKP 365
Query: 408 RPGTC-PGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTI 466
RPG C + S+ + PD+ + F++ HPLM +V P+ RP +++ Y T I
Sbjct: 366 RPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQI 423
Query: 467 AVDQVDAADGR-YEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTI 525
VD+ A DG Y+V+F+ TDRG + K I L E ++EE ++F+D PV+T+ +
Sbjct: 424 VVDRTQALDGTVYDVMFVSTDRGALHKAISL-----EHAVHIIEETQLFQDFEPVQTLLL 478
Query: 526 SSKR--QQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAW 568
SSK+ + +Y S GV L C +G C DC LARDPYCAW
Sbjct: 479 SSKKGNRFVYAGSNSGVVQAPLAFCGKHG-TCEDCVLARDPYCAW 522
>gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]
Length = 998
Score = 294 bits (753), Expect = 2e-79
Identities = 182/566 (32%), Positives = 285/566 (50%), Gaps = 74/566 (13%)
Query: 56 DYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLI----IHWAASPQRIEECVLSGKDV 111
D++++LK D +Y+ +D V +++L+++ + +I + W + Q E C + GK
Sbjct: 58 DFQLMLKIRD--TLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHK 115
Query: 112 NGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATD 171
+ EC NF+++ P N ++VCGT A+NPMC Y
Sbjct: 116 D-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYR------------------------- 149
Query: 172 GALRPMPTAPRQDYIFYLEPERLE-SGKGKCPYDPKLDTASALINEELYAGVYIDFMGTD 230
+ LE + E SG +CP+D + + + +LY+ DF+ +D
Sbjct: 150 --------------LSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASD 195
Query: 231 AAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQ-S 289
A I+R++G +A+RT +Y+S+W+ +P F+HA + +YFFFRE + E
Sbjct: 196 AVIYRSMGDGSALRTIKYDSKWIKEPHFLHAI-------EYGNYVYFFFREIAVEHNNLG 248
Query: 290 PAVYARIGRICLNDDGGHCCLVNK-WSTFLKARLVCSVPGEDGIETHFDELQDVF-VQQT 347
AVY+R+ RIC ND GG ++ K W++FLKARL CSVPG+ +FD LQ + + Q
Sbjct: 249 KAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFF--YFDVLQSITDIIQI 306
Query: 348 QDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPF-SGKMPY 406
+ P + VFT+ + GSAVC +SM DI VF G F ++ P+ W K+P
Sbjct: 307 NGI--PTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPK 364
Query: 407 PRPGTCPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTI 466
PRPG C + K++ D+PDE ++F++SHPLM AV P+ P +T YRLT I
Sbjct: 365 PRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAI 424
Query: 467 AVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVF---------KDP 517
+VD Y V+F+G++ G V KV+ + ++LEE+E + ++
Sbjct: 425 SVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEED 484
Query: 518 APVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQ-ACSRY 576
V ++ + LYVA + + + L RC+ YG+ C +RDPYC W Q +C R
Sbjct: 485 KKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRV 544
Query: 577 TASSKRRSRRQDVRHGNP--IRQCRG 600
T QD GN + C G
Sbjct: 545 TPGMLAEGYEQDTEFGNTAHLGDCHG 570
>gi|39777610 semaphorin 4B precursor [Homo sapiens]
Length = 837
Score = 294 bits (752), Expect = 2e-79
Identities = 209/657 (31%), Positives = 315/657 (47%), Gaps = 79/657 (12%)
Query: 55 TDYRILLKDEDHDRMYVGSKD--YVLSLDLHDI-NREPLIIHWAASPQRIEECVLSGKDV 111
++Y LL D +YVG+++ + LS +L + E + W A ++ ++C GKD
Sbjct: 68 SNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDP 127
Query: 112 NGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATD 171
+C N+++++ P + +HL+ CGT A++PMCTY+N +T + +G
Sbjct: 128 QRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMEN------FTLARDEKGN------ 175
Query: 172 GALRPMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDA 231
LE GKG+CP+DP + + +++ ELY G F G D
Sbjct: 176 --------------------VLLEDGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDP 215
Query: 232 AIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPD---SAERNDDKLYFFFRERSAEAP- 287
AI R+ + N WL DP+F+ + IP+ S + +DDK+YFFF E E
Sbjct: 216 AISRSQSLRPTKTESSLN--WLQDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEF 273
Query: 288 QSPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFV--Q 345
+ +RI RIC D+GG L +W++FLKA+L+CS P +DG F+ LQDVF
Sbjct: 274 FENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCSRP-DDGFP--FNVLQDVFTLSP 330
Query: 346 QTQDVRNPVIYAVFTSS--GSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGK 403
QD R+ + Y VFTS GSAVCV++M D++ VF+G + QW +
Sbjct: 331 SPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHP 390
Query: 404 MPYPRPGTC-PGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYR 462
+P PRPG C + S+ PD V+NF++ H LM V + R L+++ A Y+
Sbjct: 391 VPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQV---RSRMLLLQPQARYQ 447
Query: 463 LTTIAVDQVDAADGRYEVLFLGTDRGTVQKVI-VLPKDDQELEELMLEEVEVFKDPAPVK 521
+AV +V Y+VLFLGT G + K + V P+ ++EE+++F PV+
Sbjct: 448 --RVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVGPRVH------IIEELQIFSSGQPVQ 499
Query: 522 TMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQAC---SRYTA 578
+ + + R LY AS GV + + C Y +C DC LARDPYCAW G +C S Y
Sbjct: 500 NLLLDTHRGLLYAASHSGVVQVPMANCSLY-RSCGDCLLARDPYCAWSGSSCKHVSLYQP 558
Query: 579 SSKRRSRRQDVRHGNPIRQCRGFN------SNANKNAVESVQYGVAGSAAFLECQPRSPQ 632
R QD+ + C + + E VQ+ + L C S
Sbjct: 559 QLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQF-QPNTVNTLACPLLSNL 617
Query: 633 ATVKWLFQRDPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLYSCTATENNFKHVV 689
AT WL P + A L T LL+ QL G + C + E F+ +V
Sbjct: 618 ATRLWLRNGAPVN----ASASCHVLPTGDLLLVGTQQL---GEFQCWSLEEGFQQLV 667
>gi|39777608 semaphorin 4B precursor [Homo sapiens]
Length = 837
Score = 294 bits (752), Expect = 2e-79
Identities = 209/657 (31%), Positives = 315/657 (47%), Gaps = 79/657 (12%)
Query: 55 TDYRILLKDEDHDRMYVGSKD--YVLSLDLHDI-NREPLIIHWAASPQRIEECVLSGKDV 111
++Y LL D +YVG+++ + LS +L + E + W A ++ ++C GKD
Sbjct: 68 SNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDP 127
Query: 112 NGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATD 171
+C N+++++ P + +HL+ CGT A++PMCTY+N +T + +G
Sbjct: 128 QRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMEN------FTLARDEKGN------ 175
Query: 172 GALRPMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDA 231
LE GKG+CP+DP + + +++ ELY G F G D
Sbjct: 176 --------------------VLLEDGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDP 215
Query: 232 AIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPD---SAERNDDKLYFFFRERSAEAP- 287
AI R+ + N WL DP+F+ + IP+ S + +DDK+YFFF E E
Sbjct: 216 AISRSQSLRPTKTESSLN--WLQDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEF 273
Query: 288 QSPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFV--Q 345
+ +RI RIC D+GG L +W++FLKA+L+CS P +DG F+ LQDVF
Sbjct: 274 FENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCSRP-DDGFP--FNVLQDVFTLSP 330
Query: 346 QTQDVRNPVIYAVFTSS--GSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGK 403
QD R+ + Y VFTS GSAVCV++M D++ VF+G + QW +
Sbjct: 331 SPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHP 390
Query: 404 MPYPRPGTC-PGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYR 462
+P PRPG C + S+ PD V+NF++ H LM V + R L+++ A Y+
Sbjct: 391 VPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQV---RSRMLLLQPQARYQ 447
Query: 463 LTTIAVDQVDAADGRYEVLFLGTDRGTVQKVI-VLPKDDQELEELMLEEVEVFKDPAPVK 521
+AV +V Y+VLFLGT G + K + V P+ ++EE+++F PV+
Sbjct: 448 --RVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVGPRVH------IIEELQIFSSGQPVQ 499
Query: 522 TMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQAC---SRYTA 578
+ + + R LY AS GV + + C Y +C DC LARDPYCAW G +C S Y
Sbjct: 500 NLLLDTHRGLLYAASHSGVVQVPMANCSLY-RSCGDCLLARDPYCAWSGSSCKHVSLYQP 558
Query: 579 SSKRRSRRQDVRHGNPIRQCRGFN------SNANKNAVESVQYGVAGSAAFLECQPRSPQ 632
R QD+ + C + + E VQ+ + L C S
Sbjct: 559 QLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQF-QPNTVNTLACPLLSNL 617
Query: 633 ATVKWLFQRDPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLYSCTATENNFKHVV 689
AT WL P + A L T LL+ QL G + C + E F+ +V
Sbjct: 618 ATRLWLRNGAPVN----ASASCHVLPTGDLLLVGTQQL---GEFQCWSLEEGFQQLV 667
>gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]
Length = 597
Score = 294 bits (752), Expect = 2e-79
Identities = 180/557 (32%), Positives = 282/557 (50%), Gaps = 72/557 (12%)
Query: 56 DYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLI----IHWAASPQRIEECVLSGKDV 111
D++++LK D +Y+ +D V +++L+++ + +I + W + Q E C + GK
Sbjct: 58 DFQLMLKIRD--TLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHK 115
Query: 112 NGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATD 171
+ EC NF+++ P N ++VCGT A+NPMC Y
Sbjct: 116 D-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYR------------------------- 149
Query: 172 GALRPMPTAPRQDYIFYLEPERLE-SGKGKCPYDPKLDTASALINEELYAGVYIDFMGTD 230
+ LE + E SG +CP+D + + + +LY+ DF+ +D
Sbjct: 150 --------------LSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASD 195
Query: 231 AAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQ-S 289
A I+R++G +A+RT +Y+S+W+ +P F+HA + +YFFFRE + E
Sbjct: 196 AVIYRSMGDGSALRTIKYDSKWIKEPHFLHAI-------EYGNYVYFFFREIAVEHNNLG 248
Query: 290 PAVYARIGRICLNDDGGHCCLVNK-WSTFLKARLVCSVPGEDGIETHFDELQDVF-VQQT 347
AVY+R+ RIC ND GG ++ K W++FLKARL CSVPG+ +FD LQ + + Q
Sbjct: 249 KAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFF--YFDVLQSITDIIQI 306
Query: 348 QDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPF-SGKMPY 406
+ P + VFT+ + GSAVC +SM DI VF G F ++ P+ W K+P
Sbjct: 307 NGI--PTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPK 364
Query: 407 PRPGTCPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTI 466
PRPG C + K++ D+PDE ++F++SHPLM AV P+ P +T YRLT I
Sbjct: 365 PRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAI 424
Query: 467 AVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVF---------KDP 517
+VD Y V+F+G++ G V KV+ + ++LEE+E + ++
Sbjct: 425 SVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEED 484
Query: 518 APVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQ-ACSRY 576
V ++ + LYVA + + + L RC+ YG+ C +RDPYC W Q +C R
Sbjct: 485 KKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRV 544
Query: 577 TASSKRRSRRQDVRHGN 593
T QD GN
Sbjct: 545 TPGMLAEGYEQDTEFGN 561
>gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]
Length = 1073
Score = 294 bits (752), Expect = 2e-79
Identities = 180/557 (32%), Positives = 282/557 (50%), Gaps = 72/557 (12%)
Query: 56 DYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLI----IHWAASPQRIEECVLSGKDV 111
D++++LK D +Y+ +D V +++L+++ + +I + W + Q E C + GK
Sbjct: 58 DFQLMLKIRD--TLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHK 115
Query: 112 NGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATD 171
+ EC NF+++ P N ++VCGT A+NPMC Y
Sbjct: 116 D-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYR------------------------- 149
Query: 172 GALRPMPTAPRQDYIFYLEPERLE-SGKGKCPYDPKLDTASALINEELYAGVYIDFMGTD 230
+ LE + E SG +CP+D + + + +LY+ DF+ +D
Sbjct: 150 --------------LSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASD 195
Query: 231 AAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQ-S 289
A I+R++G +A+RT +Y+S+W+ +P F+HA + +YFFFRE + E
Sbjct: 196 AVIYRSMGDGSALRTIKYDSKWIKEPHFLHAI-------EYGNYVYFFFREIAVEHNNLG 248
Query: 290 PAVYARIGRICLNDDGGHCCLVNK-WSTFLKARLVCSVPGEDGIETHFDELQDVF-VQQT 347
AVY+R+ RIC ND GG ++ K W++FLKARL CSVPG+ +FD LQ + + Q
Sbjct: 249 KAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFF--YFDVLQSITDIIQI 306
Query: 348 QDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPF-SGKMPY 406
+ P + VFT+ + GSAVC +SM DI VF G F ++ P+ W K+P
Sbjct: 307 NGI--PTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPK 364
Query: 407 PRPGTCPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTI 466
PRPG C + K++ D+PDE ++F++SHPLM AV P+ P +T YRLT I
Sbjct: 365 PRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAI 424
Query: 467 AVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVF---------KDP 517
+VD Y V+F+G++ G V KV+ + ++LEE+E + ++
Sbjct: 425 SVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEED 484
Query: 518 APVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQ-ACSRY 576
V ++ + LYVA + + + L RC+ YG+ C +RDPYC W Q +C R
Sbjct: 485 KKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRV 544
Query: 577 TASSKRRSRRQDVRHGN 593
T QD GN
Sbjct: 545 TPGMLAEGYEQDTEFGN 561
>gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]
Length = 1017
Score = 294 bits (752), Expect = 2e-79
Identities = 180/557 (32%), Positives = 282/557 (50%), Gaps = 72/557 (12%)
Query: 56 DYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLI----IHWAASPQRIEECVLSGKDV 111
D++++LK D +Y+ +D V +++L+++ + +I + W + Q E C + GK
Sbjct: 58 DFQLMLKIRD--TLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHK 115
Query: 112 NGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATD 171
+ EC NF+++ P N ++VCGT A+NPMC Y
Sbjct: 116 D-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYR------------------------- 149
Query: 172 GALRPMPTAPRQDYIFYLEPERLE-SGKGKCPYDPKLDTASALINEELYAGVYIDFMGTD 230
+ LE + E SG +CP+D + + + +LY+ DF+ +D
Sbjct: 150 --------------LSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASD 195
Query: 231 AAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQ-S 289
A I+R++G +A+RT +Y+S+W+ +P F+HA + +YFFFRE + E
Sbjct: 196 AVIYRSMGDGSALRTIKYDSKWIKEPHFLHAI-------EYGNYVYFFFREIAVEHNNLG 248
Query: 290 PAVYARIGRICLNDDGGHCCLVNK-WSTFLKARLVCSVPGEDGIETHFDELQDVF-VQQT 347
AVY+R+ RIC ND GG ++ K W++FLKARL CSVPG+ +FD LQ + + Q
Sbjct: 249 KAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFF--YFDVLQSITDIIQI 306
Query: 348 QDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPF-SGKMPY 406
+ P + VFT+ + GSAVC +SM DI VF G F ++ P+ W K+P
Sbjct: 307 NGI--PTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPK 364
Query: 407 PRPGTCPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTI 466
PRPG C + K++ D+PDE ++F++SHPLM AV P+ P +T YRLT I
Sbjct: 365 PRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAI 424
Query: 467 AVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVF---------KDP 517
+VD Y V+F+G++ G V KV+ + ++LEE+E + ++
Sbjct: 425 SVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEED 484
Query: 518 APVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQ-ACSRY 576
V ++ + LYVA + + + L RC+ YG+ C +RDPYC W Q +C R
Sbjct: 485 KKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRV 544
Query: 577 TASSKRRSRRQDVRHGN 593
T QD GN
Sbjct: 545 TPGMLAEGYEQDTEFGN 561
>gi|21361914 semaphorin B [Homo sapiens]
Length = 761
Score = 291 bits (744), Expect = 2e-78
Identities = 201/649 (30%), Positives = 311/649 (47%), Gaps = 91/649 (14%)
Query: 56 DYRILLKDEDHDRMYVGSKDYVLSLDLHD--INREPLIIHWAASPQRIEECVLSGKDVNG 113
D+ LL D + +YVG+++ +L+LD+ D + R +I W AS ++ EC K
Sbjct: 63 DFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSNET 122
Query: 114 ECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGA 173
+C NF+R++ +N THLY CGT A++P CT++
Sbjct: 123 QCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIEL-------------------------- 156
Query: 174 LRPMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAI 233
+ Y+ + +++ GKG+ P+DP + L++ LY+G +F+G++ +
Sbjct: 157 --------QDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPIL 208
Query: 234 FRTLGKQTAMRTDQYNSRWL-NDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQSPAV 292
RTLG Q ++TD + RWL +D SF+ A IP + +YFFF E ++E +
Sbjct: 209 MRTLGSQPVLKTDNF-LRWLHHDASFVAA--IPST-----QVVYFFFEETASEFDFFERL 260
Query: 293 Y-ARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVR 351
+ +R+ R+C ND GG L KW+TFLKA+L+C+ PG + F+ ++ +
Sbjct: 261 HTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPG----QLPFNVIRHAVLLPADSPT 316
Query: 352 NPVIYAVFTSSGSV--FRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRP 409
P IYAVFTS V R SAVC +S+ DI VF G + +W + G PRP
Sbjct: 317 APHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGPETNPRP 376
Query: 410 GTCPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVD 469
G+C G PS D+ + FM+ H LM + V PL+V++G Y T +AV+
Sbjct: 377 GSCSVG---PS-------SDKALTFMKDHFLMDEQVV---GTPLLVKSGVEY--TRLAVE 421
Query: 470 QVDAADGR-YEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSK 528
DG + V++LGT G++ K +V L +EE+++F DP PV+ + ++
Sbjct: 422 TAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAHL----VEEIQLFPDPEPVRNLQLAPT 477
Query: 529 RQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWD--GQACSRYTASSKRRSRR 586
+ ++V + GV + C Y +C DC LARDP+CAWD + C +A + S +
Sbjct: 478 QGAVFVGFSGGVWRVPRANCSVY-ESCVDCVLARDPHCAWDPESRTCCLLSAPN-LNSWK 535
Query: 587 QDVRHGNPIRQC------RGFNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQ 640
QD+ GNP C R + ++ V V S L C S A+ W
Sbjct: 536 QDMERGNPEWACASGPMSRSLRPQSRPQIIKEV-LAVPNSILELPCPHLSALASYYW--- 591
Query: 641 RDPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLYSCTATENNFKHVV 689
+ G LL +Q GLY C ATEN F + V
Sbjct: 592 -----SHGPAAVPEASSTVYNGSLLLIVQDGVGGLYQCWATENGFSYPV 635
>gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]
Length = 1011
Score = 288 bits (737), Expect = 1e-77
Identities = 176/541 (32%), Positives = 278/541 (51%), Gaps = 72/541 (13%)
Query: 56 DYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLI----IHWAASPQRIEECVLSGKDV 111
D++++LK D +Y+ +D V +++L+++ + +I + W + Q E C + GK
Sbjct: 58 DFQLMLKIRD--TLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHK 115
Query: 112 NGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATD 171
+ EC NF+++ P N ++VCGT A+NPMC Y
Sbjct: 116 D-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYR------------------------- 149
Query: 172 GALRPMPTAPRQDYIFYLEPERLE-SGKGKCPYDPKLDTASALINEELYAGVYIDFMGTD 230
+ LE + E SG +CP+D + + + +LY+ DF+ +D
Sbjct: 150 --------------LSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASD 195
Query: 231 AAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQ-S 289
A I+R++G +A+RT +Y+S+W+ +P F+HA + +YFFFRE + E
Sbjct: 196 AVIYRSMGDGSALRTIKYDSKWIKEPHFLHAI-------EYGNYVYFFFREIAVEHNNLG 248
Query: 290 PAVYARIGRICLNDDGGHCCLVNK-WSTFLKARLVCSVPGEDGIETHFDELQDVF-VQQT 347
AVY+R+ RIC ND GG ++ K W++FLKARL CSVPG+ +FD LQ + + Q
Sbjct: 249 KAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFF--YFDVLQSITDIIQI 306
Query: 348 QDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPF-SGKMPY 406
+ P + VFT+ + GSAVC +SM DI VF G F ++ P+ W K+P
Sbjct: 307 NGI--PTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPK 364
Query: 407 PRPGTCPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTI 466
PRPG C + K++ D+PDE ++F++SHPLM AV P+ P +T YRLT I
Sbjct: 365 PRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAI 424
Query: 467 AVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVF---------KDP 517
+VD Y V+F+G++ G V KV+ + ++LEE+E + ++
Sbjct: 425 SVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEED 484
Query: 518 APVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQ-ACSRY 576
V ++ + LYVA + + + L RC+ YG+ C +RDPYC W Q +C R
Sbjct: 485 KKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRV 544
Query: 577 T 577
T
Sbjct: 545 T 545
>gi|11991660 sema domain, transmembrane domain (TM), and cytoplasmic
domain, (semaphorin) 6A [Homo sapiens]
Length = 1030
Score = 269 bits (687), Expect = 8e-72
Identities = 173/548 (31%), Positives = 273/548 (49%), Gaps = 77/548 (14%)
Query: 69 MYVGSKDYVLSLDLHDINREPLI----IHWAASPQRIEECVLSGKDVNGECGNFVRLIQP 124
+Y+ ++D++ ++D+ + E + + W + ++ C + GK + EC NF++++
Sbjct: 68 LYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKD-ECHNFIKVLLK 126
Query: 125 WNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQD 184
N L+VCGT A+NP C R
Sbjct: 127 KNDDALFVCGTNAFNPSC---------------------------------------RNY 147
Query: 185 YIFYLEPERLE-SGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAM 243
+ LEP E SG +CPYD K + + +LY+ DF+ DA I+R+LG+ +
Sbjct: 148 KMDTLEPFGDEFSGMARCPYDAKHANVALFADGKLYSATVTDFLAIDAVIYRSLGESPTL 207
Query: 244 RTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEA-PQSPAVYARIGRICLN 302
RT +++S+WL +P F+ A D +YFFFRE + E V+ R+ ++C N
Sbjct: 208 RTVKHDSKWLKEPYFVQAV-------DYGDYIYFFFREIAVEYNTMGKVVFPRVAQVCKN 260
Query: 303 DDGGHCCLVNK-WSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVR---NPVIYAV 358
D GG ++ K W++FLKARL CSVPG+ +F+ LQ V T +R V+ A
Sbjct: 261 DMGGSQRVLEKQWTSFLKARLNCSVPGDSHF--YFNILQAV----TDVIRINGRDVVLAT 314
Query: 359 FTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSG-KMPYPRPGTCPGGTF 417
F++ + GSAVC Y M DI VF G F ++ P+ W P ++P PRPG C G +
Sbjct: 315 FSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSS 374
Query: 418 TPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGR 477
++ ++PD+ +NF+++HPLM +AV + RP +RT YRLT IAVD
Sbjct: 375 LERYATSNEFPDDTLNFIKTHPLMDEAVPSIFNRPWFLRTMVRYRLTKIAVDTAAGPYQN 434
Query: 478 YEVLFLGTDRGTVQKVIVLPKDDQEL-EELMLEEVEVFK---------DPAPVKTMTISS 527
+ V+FLG+++G + K + + L + L LEE+ V+ + + M +
Sbjct: 435 HTVVFLGSEKGIILKFLARIGNSGFLNDSLFLEEMSVYNSEKCSYDGVEDKRIMGMQLDR 494
Query: 528 KRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAW--DGQACSRYTASSKRRSR 585
LYVA + V + L RC+ +G C +RDPYC W +G ACS + +S R +
Sbjct: 495 ASSSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWIKEGGACSHLSPNS-RLTF 553
Query: 586 RQDVRHGN 593
QD+ GN
Sbjct: 554 EQDIERGN 561
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 261 bits (666), Expect = 2e-69
Identities = 178/539 (33%), Positives = 268/539 (49%), Gaps = 70/539 (12%)
Query: 56 DYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGEC 115
D+ L D +++ VG+++Y+ L L +++ WA+S C GK EC
Sbjct: 125 DFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQAT-EWASSEDTRRSCQSKGK-TEEEC 182
Query: 116 GNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALR 175
N+VR++ R +++CGT A++PMCT SR R
Sbjct: 183 QNYVRVLIVAGRK-VFMCGTNAFSPMCT-----------------------SRQVGNLSR 218
Query: 176 PMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALINE-ELYAGVYIDFMGTDAAIF 234
+ E++ +G +CPYDP+ ++ + + ++ ELYA IDF G D AI+
Sbjct: 219 TI--------------EKI-NGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIY 263
Query: 235 RTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQSPAVYA 294
R+LG +RT QYNS+WLN+P+F+ A I A YFF RE + E VY+
Sbjct: 264 RSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLFA-------YFFLRENAVEHDCGRTVYS 316
Query: 295 RIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPV 354
R+ R+C ND GG L + W+TF+KARL CS PGE + +++ELQ F QD +
Sbjct: 317 RVARVCKNDVGGRFLLEDTWTTFMKARLNCSRPGE--VPFYYNELQSAFHLPEQD----L 370
Query: 355 IYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPG 414
IY VFT++ + SAVC ++++ I FNGPF ++E P W+P + +P + GT
Sbjct: 371 IYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPIANPIPNFQCGT--- 427
Query: 415 GTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAA 474
P ++ + + + LM +AV P+ P V + R + + VD V A
Sbjct: 428 ---LPETGPNENLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSV--RFSHLVVDLVQAK 482
Query: 475 DGRYEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKD--PAPVKTMTISSKRQQL 532
D Y VL++GT+ GT+ K L + L LEE+ V P++++ I + L
Sbjct: 483 DTLYHVLYIGTESGTILK--ALSTASRSLHGCYLEELHVLPPGRREPLRSLRILHSARAL 540
Query: 533 YVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDG--QACSRYTASSKRRSRRQDV 589
+V GV + L RC AY + A C ARDPYC WDG Q CS SS Q++
Sbjct: 541 FVGLRDGVLRVPLERCAAYRSQGA-CLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNI 598
>gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]
Length = 476
Score = 254 bits (649), Expect = 2e-67
Identities = 155/468 (33%), Positives = 245/468 (52%), Gaps = 62/468 (13%)
Query: 56 DYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLI----IHWAASPQRIEECVLSGKDV 111
D++++LK D +Y+ +D V +++L+++ + +I + W + Q E C + GK
Sbjct: 58 DFQLMLKIRD--TLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHK 115
Query: 112 NGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATD 171
+ EC NF+++ P N ++VCGT A+NPMC Y
Sbjct: 116 D-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYR------------------------- 149
Query: 172 GALRPMPTAPRQDYIFYLEPERLE-SGKGKCPYDPKLDTASALINEELYAGVYIDFMGTD 230
+ LE + E SG +CP+D + + + +LY+ DF+ +D
Sbjct: 150 --------------LSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASD 195
Query: 231 AAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQ-S 289
A I+R++G +A+RT +Y+S+W+ +P F+HA + +YFFFRE + E
Sbjct: 196 AVIYRSMGDGSALRTIKYDSKWIKEPHFLHAI-------EYGNYVYFFFREIAVEHNNLG 248
Query: 290 PAVYARIGRICLNDDGGHCCLVNK-WSTFLKARLVCSVPGEDGIETHFDELQDVF-VQQT 347
AVY+R+ RIC ND GG ++ K W++FLKARL CSVPG+ +FD LQ + + Q
Sbjct: 249 KAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFF--YFDVLQSITDIIQI 306
Query: 348 QDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPF-SGKMPY 406
+ P + VFT+ + GSAVC +SM DI VF G F ++ P+ W K+P
Sbjct: 307 NGI--PTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPK 364
Query: 407 PRPGTCPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTI 466
PRPG C + K++ D+PDE ++F++SHPLM AV P+ P +T YRLT I
Sbjct: 365 PRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAI 424
Query: 467 AVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVF 514
+VD Y V+F+G++ G V KV+ + ++LEE+E +
Sbjct: 425 SVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAY 472
>gi|19923279 semaphorin W [Homo sapiens]
Length = 770
Score = 252 bits (644), Expect = 8e-67
Identities = 206/696 (29%), Positives = 303/696 (43%), Gaps = 86/696 (12%)
Query: 12 LLTGAWPSFPTQDHLP-ATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMY 70
LL A S P +P + PR L E + T + +T +Y +LL D +Y
Sbjct: 22 LLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFA---VPHTYNYSVLLVDPASHTLY 78
Query: 71 VGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRTHL 130
VG++D + +L L P I W + C GK + EC NFV+++ N +HL
Sbjct: 79 VGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKED-ECHNFVQILAIANASHL 137
Query: 131 YVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQDYIFYLE 190
CGT A++P C ++ R Q
Sbjct: 138 LTCGTFAFDPKCGVIDVSRFQQV------------------------------------- 160
Query: 191 PERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGK-QTAMRTDQYN 249
ERLESG+GKCP++P +A+ + LYA +++GT+ I R +G+ + +RTD
Sbjct: 161 -ERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLP 219
Query: 250 SRWLNDPSFIHAELIPDSA---ERNDDKLYFFFRERSAEAPQSPAV-YARIGRICLNDDG 305
S WLN P+F+ A + + E DD++YFFF E S + R+ R+C D G
Sbjct: 220 S-WLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLG 278
Query: 306 GHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQ-DVRNPVIYAVFTSSGS 364
G L +W+TFLKA L+C P E G + LQDV V + + P+ Y +F+S
Sbjct: 279 GRKTLQQRWTTFLKADLLCPGP-EHGRAS--SVLQDVAVLRPELGAGTPIFYGIFSSQWE 335
Query: 365 VFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMP-FSGKMPYPRPGTCPGGTFTPSMK- 422
SAVC + DIR V NGPF + + +P +P PRPG C T +MK
Sbjct: 336 GATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGEC----ITNNMKL 391
Query: 423 ----STKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRY 478
S+ PD V+ F+R HPLM + V+P PL+V T Y L +A + Y
Sbjct: 392 RHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAY-LRVVAHRVTSLSGKEY 450
Query: 479 EVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAV 538
+VL+LGT+ G + + + + LE+L L F +P PV+ M + L V S
Sbjct: 451 DVLYLGTEDGHLHRAVRIGAQLSVLEDLAL-----FPEPQPVENMKL--YHSWLLVGSRT 503
Query: 539 GVTHLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQC 598
VT ++ C +C++C LA+DP CAW + + + R QD+ + C
Sbjct: 504 EVTQVNTTNCGRL-QSCSECILAQDPVCAWSFRLDECVAHAGEHRGLVQDIESADVSSLC 562
Query: 599 RGFNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDRFLR 658
+ V V A L C P S A+ W + G R + +
Sbjct: 563 P--KEPGERPVVFEVPVATAAHVV-LPCSPSSAWASCVW--HQPSGVTALTPRRDGLEVV 617
Query: 659 TEQGLLLRALQLSDRGLYSCTATENNFKHVVTRVQL 694
G + G Y+C E HVV L
Sbjct: 618 VTPGAM---------GAYACECQEGGAAHVVAAYSL 644
>gi|16306552 semaphorin Y [Homo sapiens]
Length = 930
Score = 241 bits (615), Expect = 2e-63
Identities = 159/520 (30%), Positives = 253/520 (48%), Gaps = 73/520 (14%)
Query: 69 MYVGSKDYVLSLDLH-DINREPLI----IHWAASPQRIEECVLSGKDVNGECGNFVRLIQ 123
+ V ++D+V S DL + E L+ + W + Q +E C + GK + EC N++R++
Sbjct: 73 LLVAARDHVFSFDLQAEEEGEGLVPNKYLTWRS--QDVENCAVRGK-LTDECYNYIRVLV 129
Query: 124 PWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQ 183
PW+ L CGT +++P+C R
Sbjct: 130 PWDSQTLLACGTNSFSPVC---------------------------------------RS 150
Query: 184 DYIFYLEPERLE-SGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTA 242
I L+ E E SG+ +CP+D + LY+ DF +DA ++R+LG Q
Sbjct: 151 YGITSLQQEGEELSGQARCPFDATQSNVAIFAEGSLYSATAADFQASDAVVYRSLGPQPP 210
Query: 243 MRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQSPAV-YARIGRICL 301
+R+ +Y+S+WL +P F+ A + D +YFFFRE S E + V ++R+ R+C
Sbjct: 211 LRSAKYDSKWLREPHFV-------QALEHGDHVYFFFREVSVEDARLGRVQFSRVARVCK 263
Query: 302 NDDGGH-CCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFT 360
D GG L W++FLK RL CSVPG+ +FD LQ + R+ ++ VFT
Sbjct: 264 RDMGGSPRALDRHWTSFLKLRLNCSVPGDSTF--YFDVLQALTGPVNLHGRS-ALFGVFT 320
Query: 361 SSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFS-GKMPYPRPGTCPGGTFTP 419
+ + GSAVC + + +I F G F + + W P S ++P PRPG+C G
Sbjct: 321 TQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPVSEDRVPSPRPGSCAGVGGAA 380
Query: 420 SMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYE 479
S++D PD+V+ F+++HPL+ AV P+ +PL+ T LT +AVD +
Sbjct: 381 LFSSSRDLPDDVLTFIKAHPLLDPAVPPVTHQPLLTLTSRAL-LTQVAVDGMAGPHSNIT 439
Query: 480 VLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKRQ--------- 530
V+FLG++ GTV KV+ E ++LEE++ + T + R+
Sbjct: 440 VMFLGSNDGTVLKVLTPGGRSGGPEPILLEEIDAYSPARCSGKRTAQTARRIIGLELDTE 499
Query: 531 --QLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAW 568
+L+VA + + +L L RC +GA C ++DPYC W
Sbjct: 500 GHRLFVAFSGCIVYLPLSRCARHGACQRSCLASQDPYCGW 539
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 238 bits (606), Expect = 2e-62
Identities = 160/520 (30%), Positives = 252/520 (48%), Gaps = 69/520 (13%)
Query: 53 NTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVN 112
N D+ L D + VG+++Y+ L L D++ + W + C GK
Sbjct: 54 NAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAV-EWECDEATKKACYSKGKSKE 112
Query: 113 GECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDG 172
EC N++R++ L+ CGT A+ P+CT NR S T+
Sbjct: 113 -ECQNYIRVLLVGG-DRLFTCGTNAFTPVCT--NRSL-----------------SNLTE- 150
Query: 173 ALRPMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALI-NEELYAGVYIDFMGTDA 231
D I SG +CPY P+ ++ + L ELYA +DF G D
Sbjct: 151 ---------IHDQI---------SGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDP 192
Query: 232 AIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQSPA 291
AI+R+LG +RT QYNS+WLN+P+F+ + I + YFFFRE + E
Sbjct: 193 AIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFT-------YFFFRENAVEHDCGKT 245
Query: 292 VYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVR 351
V++R R+C ND GG L + W+TF+KARL CS PGE + +++ELQ F D
Sbjct: 246 VFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGE--VPFYYNELQSTFFLPELD-- 301
Query: 352 NPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGT 411
+IY +FT++ + SAVCV++++ I F+GPF ++E W+P+ P+ + GT
Sbjct: 302 --LIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGT 359
Query: 412 CPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQV 471
G + + + + + LM++ V P+ P + + R + +AVD V
Sbjct: 360 VDQGLYV-------NLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNS--RFSHVAVDVV 410
Query: 472 DAADGRYEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKD--PAPVKTMTISSKR 529
+ +++L TD GT++KV V +Q +LEE+E+F + P++++ I +
Sbjct: 411 QGREALVHIIYLATDYGTIKKVRV--PLNQTSSSCLLEEIELFPERRREPIRSLQILHSQ 468
Query: 530 QQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWD 569
L+V V + L RCQ Y + C A+DPYC WD
Sbjct: 469 SVLFVGLREHVVKIPLKRCQFYRTR-STCIGAQDPYCGWD 507
>gi|19718780 semaphorin 6B precursor [Homo sapiens]
Length = 888
Score = 237 bits (604), Expect = 4e-62
Identities = 165/544 (30%), Positives = 260/544 (47%), Gaps = 76/544 (13%)
Query: 69 MYVGSKDYVLSLDLHDINREPLI----IHWAASPQRIEECVLSGKDVNGECGNFVRLIQP 124
+++G +D + ++L L + W ++P I C + GK GEC NFV+++
Sbjct: 77 LFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQ-EGECRNFVKVLLL 135
Query: 125 WNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQD 184
+ + L+VCG+ A+NP+C + + L+P+ D
Sbjct: 136 RDESTLFVCGSNAFNPVC------------------------ANYSIDTLQPVG-----D 166
Query: 185 YIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAMR 244
I SG +CPYDPK + + L+ DF+ DA I+R+LG + +R
Sbjct: 167 NI---------SGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLR 217
Query: 245 TDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQ-SPAVYARIGRICLND 303
T +++S+W +P F+H A +YFFFRE + E V +R+ R+C ND
Sbjct: 218 TVKHDSKWFKEPYFVH-------AVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKND 270
Query: 304 DGGHCCLVNK-WSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSS 362
GG ++ K W++FLKARL CSVPG+ +F+ LQ V + R PV+ AVF++
Sbjct: 271 VGGSPRVLEKQWTSFLKARLNCSVPGDS--HFYFNVLQAVTGVVSLGGR-PVVLAVFSTP 327
Query: 363 GSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPF-SGKMPYPRPGTC--PGGTFTP 419
+ GSAVC + + + VF G F ++ P W P ++P PRPG C PG +
Sbjct: 328 SNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYNA 387
Query: 420 SMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYE 479
S PD+++NF+++HPLM +AV L P ++RT ++LT +AVD G
Sbjct: 388 S----SALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQT 443
Query: 480 VLFLGTDRGTVQKVIVLPKDDQELE---ELMLEEVEVFKD-----PAPVKT------MTI 525
V+FLG++ GTV K +V P + LEE E ++ P +T + +
Sbjct: 444 VVFLGSEAGTVLKFLVRPNASTSGTSGLSVFLEEFETYRPDRCGRPGGGETGQRLLSLEL 503
Query: 526 SSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSR 585
+ L A V + + RCQ Y +C ++DPYC W + + R +
Sbjct: 504 DAASGGLLAAFPRCVVRVPVARCQQYSGCMKNCIGSQDPYCGWAPDGSCIFLSPGTRAAF 563
Query: 586 RQDV 589
QDV
Sbjct: 564 EQDV 567
>gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]
Length = 666
Score = 197 bits (501), Expect = 3e-50
Identities = 184/717 (25%), Positives = 300/717 (41%), Gaps = 119/717 (16%)
Query: 6 LLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDED 65
LLLWA+ + Q HL + PR+ +K F T + +L +
Sbjct: 35 LLLWAAAASA-------QGHLRSGPRIFAVWKGHVGQDRVDFGQ----TEPHTVLFHEPG 83
Query: 66 HDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNG-ECGNFVRLIQP 124
++VG + V D + AS + + G ++ +C N++ L++
Sbjct: 84 SSSVWVGGRGKVYLFDFPEGKN--------ASVRTVNIGSTKGSCLDKRDCENYITLLER 135
Query: 125 WNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQD 184
+ L CGT A +P C W +G + P
Sbjct: 136 RSEG-LLACGTNARHPSC-------------WN-----------LVNGTVVP-------- 162
Query: 185 YIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAMR 244
L +G P+ P ++ +E+Y+ + FR + ++ +
Sbjct: 163 ---------LGEMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELY 213
Query: 245 TDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEA-PQSPAVYARIGRICLND 303
T + + +P FI A ++ + DDK+Y+FFRE + + P++P +R+ ++C D
Sbjct: 214 T---SDTVMQNPQFIKATIVHQD-QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGD 269
Query: 304 DGGHCCL-VNKWSTFLKARLVCSVPGEDGIETHFDELQDVFV--QQTQDVRNPVIYAVFT 360
GG L V+KW+TFLKA LVCS + +F+ LQDVF+ + R+ +Y VF+
Sbjct: 270 QGGESSLSVSKWNTFLKAMLVCS---DAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFS 326
Query: 361 SSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPS 420
+ + SAVCVYS+ DI VF + +P PRPG C
Sbjct: 327 NPWNY---SAVCVYSLGDIDKVFR---------TSSLKGYHSSLPNPRPGKC-------- 366
Query: 421 MKSTKDYPDEVINFMRSHPLMYQAVYPLQ--RRPLVVRTGAPYRLTTIAVDQVDAADGR- 477
+ + P E HP + Q V P+ + PL + Y +AV ++ A+ G
Sbjct: 367 LPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLF---HSKYHYQKVAVHRMQASHGET 423
Query: 478 YEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASA 537
+ VL+L TDRGT+ KV+ P + + + E++ F+ A ++TM++ ++R++LYV+S
Sbjct: 424 FHVLYLTTDRGTIHKVVE-PGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQ 482
Query: 538 VGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQ 597
V+ + L C+ YG C C ++RDPYC WD C + S RS Q + P ++
Sbjct: 483 WEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRC--ISIYSSERSVLQSINPAEPHKE 540
Query: 598 CRGFNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDRFL 657
C N +K ++ V S +L C S AT W + + E E
Sbjct: 541 CP--NPKPDKAPLQKVSL-APNSRYYLSCPMESRHATYSWRHKENV-----EQSCEPGHQ 592
Query: 658 RTEQGLLLRALQLSDRGLYSCTATENNFKHVVTRVQL---------HVLGRDAVHAA 705
L + L G Y C A E ++ QL H+LG AA
Sbjct: 593 SPNCILFIENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHACALAA 649
>gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens]
Length = 652
Score = 197 bits (500), Expect = 4e-50
Identities = 184/718 (25%), Positives = 297/718 (41%), Gaps = 135/718 (18%)
Query: 6 LLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDED 65
LLLWA+ + Q HL + PR+ +K F T + +L +
Sbjct: 35 LLLWAAAASA-------QGHLRSGPRIFAVWKGHVGQDRVDFGQ----TEPHTVLFHEPG 83
Query: 66 HDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKD--VNGECGNFVRLIQ 123
++VG + V D + GK+ V +C N++ L++
Sbjct: 84 SSSVWVGGRGKVYLFDFPE-----------------------GKNASVRTDCENYITLLE 120
Query: 124 PWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQ 183
+ L CGT A +P C W +G + P
Sbjct: 121 RRSEG-LLACGTNARHPSC-------------WN-----------LVNGTVVP------- 148
Query: 184 DYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAM 243
L +G P+ P ++ +E+Y+ + FR + ++ +
Sbjct: 149 ----------LGEMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESEL 198
Query: 244 RTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEA-PQSPAVYARIGRICLN 302
T + + +P FI A ++ + DDK+Y+FFRE + + P++P +R+ ++C
Sbjct: 199 YT---SDTVMQNPQFIKATIVHQD-QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRG 254
Query: 303 DDGGHCCL-VNKWSTFLKARLVCSVPGEDGIETHFDELQDVFV--QQTQDVRNPVIYAVF 359
D GG L V+KW+TFLKA LVCS + +F+ LQDVF+ + R+ +Y VF
Sbjct: 255 DQGGESSLSVSKWNTFLKAMLVCS---DAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVF 311
Query: 360 TSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTP 419
++ + SAVCVYS+ DI VF + +P PRPG C
Sbjct: 312 SNPWNY---SAVCVYSLGDIDKVFR---------TSSLKGYHSSLPNPRPGKC------- 352
Query: 420 SMKSTKDYPDEVINFMRSHPLMYQAVYPLQ--RRPLVVRTGAPYRLTTIAVDQVDAADGR 477
+ + P E HP + Q V P+ + PL + Y +AV ++ A+ G
Sbjct: 353 -LPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLF---HSKYHYQKVAVHRMQASHGE 408
Query: 478 -YEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVAS 536
+ VL+L TDRGT+ KV+ P + + + E++ F+ A ++TM++ ++R++LYV+S
Sbjct: 409 TFHVLYLTTDRGTIHKVVE-PGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSS 467
Query: 537 AVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIR 596
V+ + L C+ YG C C ++RDPYC WD C + S RS Q + P +
Sbjct: 468 QWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRC--ISIYSSERSVLQSINPAEPHK 525
Query: 597 QCRGFNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDRF 656
+C N +K ++ V S +L C S AT W + + E E
Sbjct: 526 ECP--NPKPDKAPLQKVSL-APNSRYYLSCPMESRHATYSWRHKENV-----EQSCEPGH 577
Query: 657 LRTEQGLLLRALQLSDRGLYSCTATENNFKHVVTRVQL---------HVLGRDAVHAA 705
L + L G Y C A E ++ QL H+LG AA
Sbjct: 578 QSPNCILFIENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHACALAA 635
>gi|225637524 semaphorin 7A isoform 3 [Homo sapiens]
Length = 501
Score = 194 bits (494), Expect = 2e-49
Identities = 149/524 (28%), Positives = 240/524 (45%), Gaps = 57/524 (10%)
Query: 198 KGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAMRTDQYNSRWLNDPS 257
+G P+ P ++ +E+Y+ + FR + ++ + T + + +P
Sbjct: 2 RGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYT---SDTVMQNPQ 58
Query: 258 FIHAELIPDSAERNDDKLYFFFRERSAEA-PQSPAVYARIGRICLNDDGGHCCL-VNKWS 315
FI A ++ + DDK+Y+FFRE + + P++P +R+ ++C D GG L V+KW+
Sbjct: 59 FIKATIVHQD-QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWN 117
Query: 316 TFLKARLVCSVPGEDGIETHFDELQDVFV--QQTQDVRNPVIYAVFTSSGSVFRGSAVCV 373
TFLKA LVCS + +F+ LQDVF+ + R+ +Y VF++ + SAVCV
Sbjct: 118 TFLKAMLVCS---DAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY---SAVCV 171
Query: 374 YSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVIN 433
YS+ DI VF + +P PRPG C + + P E
Sbjct: 172 YSLGDIDKVFR---------TSSLKGYHSSLPNPRPGKC--------LPDQQPIPTETFQ 214
Query: 434 FMRSHPLMYQAVYPLQ--RRPLVVRTGAPYRLTTIAVDQVDAADGR-YEVLFLGTDRGTV 490
HP + Q V P+ + PL + Y +AV ++ A+ G + VL+L TDRGT+
Sbjct: 215 VADRHPEVAQRVEPMGPLKTPLF---HSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTI 271
Query: 491 QKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGVTHLSLHRCQA 550
KV+ P + + + E++ F+ A ++TM++ ++R++LYV+S V+ + L C+
Sbjct: 272 HKVVE-PGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEV 330
Query: 551 YGAACADCCLARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRGFNSNANKNAV 610
YG C C ++RDPYC WD C + S RS Q + P ++C N +K +
Sbjct: 331 YGGGCHGCLMSRDPYCGWDQGRC--ISIYSSERSVLQSINPAEPHKECP--NPKPDKAPL 386
Query: 611 ESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDRFLRTEQGLLLRALQL 670
+ V S +L C S AT W + + E E L + L
Sbjct: 387 QKVSL-APNSRYYLSCPMESRHATYSWRHKENV-----EQSCEPGHQSPNCILFIENLTA 440
Query: 671 SDRGLYSCTATENNFKHVVTRVQL---------HVLGRDAVHAA 705
G Y C A E ++ QL H+LG AA
Sbjct: 441 QQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHACALAA 484
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,561,362
Number of Sequences: 37866
Number of extensions: 1887380
Number of successful extensions: 12271
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 207
Number of HSP's that attempted gapping in prelim test: 10349
Number of HSP's gapped (non-prelim): 1506
length of query: 785
length of database: 18,247,518
effective HSP length: 110
effective length of query: 675
effective length of database: 14,082,258
effective search space: 9505524150
effective search space used: 9505524150
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.