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Search of human proteins with 188035924
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
(539 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 1093 0.0
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 215 7e-56
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 215 9e-56
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 214 1e-55
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 206 4e-53
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 205 7e-53
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 198 1e-50
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 197 2e-50
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 190 2e-48
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 187 2e-47
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 186 6e-47
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 184 2e-46
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 179 4e-45
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 175 1e-43
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 155 1e-37
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 135 1e-31
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 113 4e-25
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 113 4e-25
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 113 4e-25
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 100 4e-21
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 92 1e-18
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 92 1e-18
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 92 1e-18
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 91 3e-18
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 91 3e-18
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 81 3e-15
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 81 3e-15
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 75 2e-13
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens] 75 2e-13
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 72 1e-12
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 1093 bits (2826), Expect = 0.0
Identities = 539/539 (100%), Positives = 539/539 (100%)
Query: 1 MWRLPRALCVHAAKTSKLSGPWSRPAAFMSTLLINQPQYAWLKELGLREENEGVYNGSWG 60
MWRLPRALCVHAAKTSKLSGPWSRPAAFMSTLLINQPQYAWLKELGLREENEGVYNGSWG
Sbjct: 1 MWRLPRALCVHAAKTSKLSGPWSRPAAFMSTLLINQPQYAWLKELGLREENEGVYNGSWG 60
Query: 61 GRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDA 120
GRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDA
Sbjct: 61 GRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDA 120
Query: 121 LREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIE 180
LREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIE
Sbjct: 121 LREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIE 180
Query: 181 QWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLED 240
QWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLED
Sbjct: 181 QWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLED 240
Query: 241 NKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGN 300
NKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGN
Sbjct: 241 NKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGN 300
Query: 301 NAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVG 360
NAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVG
Sbjct: 301 NAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVG 360
Query: 361 NPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHD 420
NPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHD
Sbjct: 361 NPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHD 420
Query: 421 ASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGI 480
ASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGI
Sbjct: 421 ASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGI 480
Query: 481 VNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ 539
VNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ
Sbjct: 481 VNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ 539
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 215 bits (548), Expect = 7e-56
Identities = 148/480 (30%), Positives = 230/480 (47%), Gaps = 22/480 (4%)
Query: 56 NGSWGGR--GEVITTYCPANNEPIARVRQASVADYEETVKKAREAWK---IWADIPAPKR 110
N W G V Y PA E + V++A AD ++ V+ AR A+ +W + A +R
Sbjct: 43 NNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASER 102
Query: 111 GEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVG-EVQEYVDICDYAVGLSRMIGGPIL 169
G ++ ++ D + VL ++ SL GK ++ ++Q + Y G + I G +
Sbjct: 103 GRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTI 162
Query: 170 PSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVA 229
P + + + P+G+ G I +NFP+ ++ W A A+ CGN + K A T L ++
Sbjct: 163 PVD-GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALY 221
Query: 230 VTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQER 289
+ +I E PG I L G G A+A ++ ++FTGST+VGK ++QE
Sbjct: 222 MGALIK---EAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGK----LIQEA 274
Query: 290 FGRS-----LLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHD 344
GRS LELGG + I F DADL V A GQ CT R+F+ ESI++
Sbjct: 275 AGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYE 334
Query: 345 EVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDR 404
E V R + + VG+P+DP GP K+ + L ++ EG + GGK + R
Sbjct: 335 EFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGR 394
Query: 405 PGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDL 464
G ++EPT+ + + D IA E F P+ + +FK +EV N GL +++FT D+
Sbjct: 395 KGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDI 454
Query: 465 GRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
+ G V +N + FGG K +G GRE G ++Y T T+
Sbjct: 455 NKAL--TVSSAMQAGTVWINC-YNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTV 511
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 215 bits (547), Expect = 9e-56
Identities = 149/467 (31%), Positives = 227/467 (48%), Gaps = 22/467 (4%)
Query: 68 TYCPANNEPIARVRQASVADYEETVKKAREAWKI---WADIPAPKRGEIVRQIGDALREK 124
T P E I V + AD + VK AREA+++ W + A +RG ++ ++ D +
Sbjct: 56 TVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERD 115
Query: 125 IQVLGSLVSLEMGKILVEGVG-EVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWN 183
L SL +L+ GK E ++ E + + Y G + G +P + H +
Sbjct: 116 RVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQ-HFCFTRHE 174
Query: 184 PVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKL 243
PVG+ G I +NFP+ + GW A A+ GN + K A T L ++ + +I E
Sbjct: 175 PVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIK---EAGFP 231
Query: 244 PGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFG-----RSLLELG 298
PG + +T G G A+A+ V+ ++FTGST+VG ++Q+ G R LELG
Sbjct: 232 PGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGH----LIQKAAGDSNLKRVTLELG 287
Query: 299 GNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIR 358
G + I DAD+ V A GQ C R F+ ESI++E + R + Q +
Sbjct: 288 GKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRK 347
Query: 359 VGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLG 418
VGNP++ + GP K+ LG ++ +KEG ++ GG+ G +++PT+ G+
Sbjct: 348 VGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQ 407
Query: 419 HDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDC 478
D IA E F P+ +FKFK EEV N + GL++++FT+DL + + +
Sbjct: 408 DDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGT 467
Query: 479 GIVNV-NIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
VN NI T FGG K +G GRE G D K Y T TI
Sbjct: 468 VWVNTYNIVTCHT----PFGGFKESGNGRELGEDGLKAYTEVKTVTI 510
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 214 bits (546), Expect = 1e-55
Identities = 136/474 (28%), Positives = 239/474 (50%), Gaps = 17/474 (3%)
Query: 63 GEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKI--WADIPAPKRGEIVRQIGDA 120
G+ T P + I +V AS+AD ++ V A++A++ W + A +RG ++ ++ D
Sbjct: 457 GKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADL 516
Query: 121 LREKIQVLGSLVSLEMGKILVEGVG-EVQEYVDICDYAVGLSRMIGGPILPSERSG---H 176
L E + L ++ +L+ G + + + V Y G I G +P ++ +
Sbjct: 517 LEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRN 576
Query: 177 ALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAK 236
+ P+G+ II +N+P+ + W +A + GN + K A T L ++ ++ K
Sbjct: 577 LTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVK 636
Query: 237 VLEDNKLPGAICSLTCGGADI-GTAMAKDERVNLLSFTGSTQVGKQV-GLMVQERFGRSL 294
P + ++ G I G +++ + L FTGST +GKQ+ +
Sbjct: 637 A----GFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVS 692
Query: 295 LELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAY 354
LELGG + +I F D +L V + A G+ C A RLF+ ESIHDE V R+ +
Sbjct: 693 LELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEI 752
Query: 355 AQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIV 414
++++G+P D + +GP + K + L E KEG T+VYGG+ + RPG ++EPT+
Sbjct: 753 KKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVF 812
Query: 415 TGLGHDASIAHTETFAPILYVFKFKNE--EEVFAWNNEVKQGLSSSIFTKDLGRIFRWLG 472
T + +A E+F PI+ + KF+N + V N + GL+S +FT+D+ + ++
Sbjct: 813 TDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDINKAM-YVS 871
Query: 473 PKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINY 526
K + G V +N + ++ FGG K +G G++ G +A +Y++ T T+ Y
Sbjct: 872 EK-LEAGTVFIN-TYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTLEY 923
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 206 bits (524), Expect = 4e-53
Identities = 144/487 (29%), Positives = 230/487 (47%), Gaps = 22/487 (4%)
Query: 56 NGSW--GGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKI---WADIPAPKR 110
N W G+ T P+ E I V + D ++ V+ A+ A++ W + A R
Sbjct: 37 NNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSR 96
Query: 111 GEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVG-EVQEYVDICDYAVGLSRMIGGPIL 169
G ++ Q+ D + L +L +++ GK + +++ + Y G + I G +
Sbjct: 97 GRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTI 156
Query: 170 PSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVA 229
P++ + P+G+ G IT +NFP+ + W A A+ CGN + K A T L ++
Sbjct: 157 PTD-DNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALY 215
Query: 230 VTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQER 289
+ +I E PG + + G +G A++ ++N ++FTGST+VGK +V+E
Sbjct: 216 LGSLIK---EAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGK----LVKEA 268
Query: 290 FGRS-----LLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHD 344
RS LELGG N I DADL L V A GQ CT A R+F+ E ++
Sbjct: 269 ASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYS 328
Query: 345 EVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDR 404
E V R + + VG+P+D GP ++ L +E KKEG + GG M+
Sbjct: 329 EFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMED 388
Query: 405 PGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDL 464
G +++PT+ + + + IA E F P+ + KFK+ EEV N GL++++FTK+L
Sbjct: 389 KGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNL 448
Query: 465 GRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
+ + + G V +N + FGG K +G GRE G A +Y T TI
Sbjct: 449 DKALKL--ASALESGTVWINC-YNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTI 505
Query: 525 NYSKDLP 531
P
Sbjct: 506 KLGDKNP 512
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 205 bits (522), Expect = 7e-53
Identities = 141/481 (29%), Positives = 227/481 (47%), Gaps = 32/481 (6%)
Query: 63 GEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKI---WADIPAPKRGEIVRQIGD 119
G+ + PA E + +V + D ++ VK AR+A++I W + A +RG ++ ++ D
Sbjct: 35 GKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLAD 94
Query: 120 ALREKIQVLGSLVSLEMGKILVEG-VGEVQEYVDICDYAVGLSRMIGGPILPSERSGHAL 178
+ +L ++ S+ GK+ + ++ + Y G + I G +P + +
Sbjct: 95 LIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTY 154
Query: 179 IEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVL 238
P+G+ G I +NFP+ + W A+ CGN + K A T L ++ V +I
Sbjct: 155 TRH-EPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIK--- 210
Query: 239 EDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRS----- 293
E PG + + G G A++ ++ ++FTGST+VGK +++E G+S
Sbjct: 211 EAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGK----LIKEAAGKSNLKRV 266
Query: 294 LLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKA 353
LELGG + I DADL V A GQ C A R+F+ ESI+DE V R +
Sbjct: 267 TLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVER 326
Query: 354 YAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTI 413
+ +GNP P V GP K+ L +E KKEG + GG G +V+PT+
Sbjct: 327 AKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTV 386
Query: 414 VTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFR---- 469
+ + + IA E F P+ + KFK+ ++V N GLS+ +FTKD+ +
Sbjct: 387 FSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSA 446
Query: 470 -WLGPKGSDC-GIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYS 527
G +C G+V+ P FGG K +G GRE G + +Y T T+ S
Sbjct: 447 LQAGTVWVNCYGVVSAQCP---------FGGFKMSGNGRELGEYGFHEYTEVKTVTVKIS 497
Query: 528 K 528
+
Sbjct: 498 Q 498
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 198 bits (503), Expect = 1e-50
Identities = 132/469 (28%), Positives = 231/469 (49%), Gaps = 17/469 (3%)
Query: 68 TYCPANNEPIARVRQASVADYEETVKKAREAWKI--WADIPAPKRGEIVRQIGDALREKI 125
T P + I +V A V D ++ V A++A++ W I A RG ++ ++ D + +
Sbjct: 441 TINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLMEQHQ 500
Query: 126 QVLGSLVSLEMGKILVEGVG-EVQEYVDICDYAVGLSRMIGGPILPSERSG---HALIEQ 181
+ L ++ +L+ G + + V + Y G I G +P ++ + + +
Sbjct: 501 EELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTR 560
Query: 182 WNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDN 241
PVG+ GII +N+P+ + W A + GN + K A T L ++ ++ K
Sbjct: 561 KEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKA---- 616
Query: 242 KLPGAICSLTCG-GADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQ-ERFGRSLLELGG 299
+P + ++ G G+ +G ++ V + FTGST+VGK + + LELGG
Sbjct: 617 GIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGG 676
Query: 300 NNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRV 359
+ +I F D DL+ V + + G+ C A RLF+ +SIHDE V R+ + +++V
Sbjct: 677 KSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKV 736
Query: 360 GNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGH 419
GNP D + +GP + + + + KEG T+V GG + RPG + EPT+ T +
Sbjct: 737 GNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVED 796
Query: 420 DASIAHTETFAPILYVFKFKNE--EEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSD 477
IA E+F P++ + +F + + V + N + GL+S +FT+D+ + ++ K
Sbjct: 797 HMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKAL-YVSDK-LQ 854
Query: 478 CGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINY 526
G V VN + ++ FGG K +G G++ G A +Y+R T T Y
Sbjct: 855 AGTVFVN-TYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTFEY 902
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 197 bits (502), Expect = 2e-50
Identities = 153/528 (28%), Positives = 239/528 (45%), Gaps = 34/528 (6%)
Query: 3 RLPRALCVHAAKTSKLSGPWSRPAAFMSTLLINQPQYAWLKELGLREENEGVYNGSWGGR 62
RL R L + AA T + P +P F + + IN E ++ V
Sbjct: 11 RLGRRL-LSAAATQAVPAPNQQPEVFCNQIFINN------------EWHDAVSR------ 51
Query: 63 GEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKI---WADIPAPKRGEIVRQIGD 119
+ T P+ E I +V + D ++ VK AR A+++ W + A RG ++ ++ D
Sbjct: 52 -KTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLAD 110
Query: 120 ALREKIQVLGSLVSLEMGK-ILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHAL 178
+ L +L +L+ GK ++ + ++ + Y G + G +P + +
Sbjct: 111 LIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSY 170
Query: 179 IEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVL 238
PVG+ G I +NFP+ + W A+ GNV + K A T L ++ V +I
Sbjct: 171 TRH-EPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIK--- 226
Query: 239 EDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMV-QERFGRSLLEL 297
E PG + + G G A+A E V+ ++FTGST++G+ + + R LEL
Sbjct: 227 EAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLEL 286
Query: 298 GGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQI 357
GG + I DAD+ V A FA GQ C R F+ E I+DE V R
Sbjct: 287 GGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSR 346
Query: 358 RVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGL 417
VGNP+D GP + LG + K+EG ++ GG + G +++PT+ +
Sbjct: 347 VVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDV 406
Query: 418 GHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSD 477
+IA E F P++ + KFK EEV N GL++++FTKDL + +L +
Sbjct: 407 QDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKA-NYLS-QALQ 464
Query: 478 CGIVNVN-IPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
G V VN GA+ FGG K +G GRE G + Y T T+
Sbjct: 465 AGTVWVNCYDVFGAQ--SPFGGYKMSGSGRELGEYGLQAYTEVKTVTV 510
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 190 bits (483), Expect = 2e-48
Identities = 131/424 (30%), Positives = 204/424 (48%), Gaps = 17/424 (4%)
Query: 107 APKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVG-EVQEYVDICDYAVGLSRMIG 165
A +RG ++ ++ D + VL ++ SL GK ++ ++Q + Y G + I
Sbjct: 3 ASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIH 62
Query: 166 GPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSL 225
G +P + + + P+G+ G I +NFP+ ++ W A A+ CGN + K A T L
Sbjct: 63 GMTIPVD-GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPL 121
Query: 226 ISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLM 285
++ + +I E PG I L G G A+A ++ ++FTGST+VGK +
Sbjct: 122 SALYMGALIK---EAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGK----L 174
Query: 286 VQERFGRS-----LLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHE 340
+QE GRS LELGG + I F DADL V A GQ CT R+F+ E
Sbjct: 175 IQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEE 234
Query: 341 SIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGK 400
SI++E V R + + VG+P+DP GP K+ + L ++ EG + GGK
Sbjct: 235 SIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGK 294
Query: 401 VMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIF 460
+ R G ++EPT+ + + D IA E F P+ + +FK +EV N GL +++F
Sbjct: 295 GLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVF 354
Query: 461 TKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRS 520
T D+ + G V +N + FGG K +G GRE G ++Y
Sbjct: 355 TNDINKAL--TVSSAMQAGTVWINC-YNALNAQSPFGGFKMSGNGREMGEFGLREYSEVK 411
Query: 521 TCTI 524
T T+
Sbjct: 412 TVTV 415
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 187 bits (476), Expect = 2e-47
Identities = 128/463 (27%), Positives = 222/463 (47%), Gaps = 20/463 (4%)
Query: 71 PANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGS 130
PA IA + + V+ A+ A+KIW+ +R I+ + +RE+ + +
Sbjct: 58 PATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIAT 117
Query: 131 LVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPI--LPSERSGHALIEQWNPVGLV 188
+ + GK + E ++ +Y GL+ + G LP G+ E P+G+
Sbjct: 118 MECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRRE---PLGVC 174
Query: 189 GIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAIC 248
I A+N+P + W +A A+ CGN ++K +P T + ++ ++A++ + +P +
Sbjct: 175 VGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL----LLAEIYSEAGVPPGLF 230
Query: 249 SLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFED 308
++ GGA G + + V +SFTGS G ++ M + LELGG + +I F D
Sbjct: 231 NVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSD 290
Query: 309 ADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVL 368
D++ V AL A T GQ C R+F+ + I D+ + K +I++G+P +
Sbjct: 291 CDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTR 350
Query: 369 YGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMD------RPGNYVEPTIVTGLGHDAS 422
GPL + + LG V+ AK++G V+ GG + + G Y+ P ++T D +
Sbjct: 351 MGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMT 410
Query: 423 IAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGP-KGSDCGIV 481
E F P++ + F E EV N+ GL++ +FT+D+ R R + + C I
Sbjct: 411 CVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFIN 470
Query: 482 NVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
N N+ S E+ FGG K +G GRE+G + Y + T +
Sbjct: 471 NYNV--SPVEL--PFGGYKKSGFGRENGRVTIEYYSQLKTVCV 509
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 186 bits (471), Expect = 6e-47
Identities = 134/480 (27%), Positives = 211/480 (43%), Gaps = 60/480 (12%)
Query: 56 NGSWGGR--GEVITTYCPANNEPIARVRQASVADYEETVKKAREAWK---IWADIPAPKR 110
N W G V Y PA E + V++A AD ++ V+ AR A+ +W + A +R
Sbjct: 43 NNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASER 102
Query: 111 GEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVG-EVQEYVDICDYAVGLSRMIGGPIL 169
G ++ ++ D + VL ++ SL GK ++ ++Q + Y G + I G +
Sbjct: 103 GRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTI 162
Query: 170 PSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVA 229
P + + + P+G+ G I +NFP+ ++ W A A+ CGN + K A T L ++
Sbjct: 163 PVD-GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALY 221
Query: 230 VTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQER 289
+ +I K+VG ++QE
Sbjct: 222 MGALI---------------------------------------------KEVGKLIQEA 236
Query: 290 FGRS-----LLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHD 344
GRS LELGG + I F DADL V A GQ CT R+F+ ESI++
Sbjct: 237 AGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYE 296
Query: 345 EVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDR 404
E V R + + VG+P+DP GP K+ + L ++ EG + GGK + R
Sbjct: 297 EFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGR 356
Query: 405 PGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDL 464
G ++EPT+ + + D IA E F P+ + +FK +EV N GL +++FT D+
Sbjct: 357 KGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDI 416
Query: 465 GRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
+ G V +N + FGG K +G GRE G ++Y T T+
Sbjct: 417 NKAL--TVSSAMQAGTVWINC-YNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTV 473
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 184 bits (466), Expect = 2e-46
Identities = 131/484 (27%), Positives = 225/484 (46%), Gaps = 16/484 (3%)
Query: 52 EGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRG 111
E +G + I +Y P+ E RV + + E VK AREA+ W+ +R
Sbjct: 11 ENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERS 70
Query: 112 EIVRQIGDALREKIQVLGSLVSLEMGKIL-VEGVGEVQEYVDICDYAVGLSRMIGGPILP 170
++ Q+ D L + ++ S + GK L + ++ V + S
Sbjct: 71 RVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQ 130
Query: 171 SERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAV 230
+ G PVG+ G+I+ +N P+ + W A AM GN + K + TS+ +
Sbjct: 131 MDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAW-- 188
Query: 231 TKIIAKVLEDNKLPGAICSLTCG-GADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQER 289
++ K+L+ +P + ++ G G +G A+ V L+SFTGS +++ +
Sbjct: 189 --MLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPH 246
Query: 290 FGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNR 349
+ LELGG N I FEDA+L +P+ + ++ G+ C R+F+ +SI+ E + R
Sbjct: 247 CKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKR 306
Query: 350 LKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKV-------M 402
+A + +VG P DP V G L +K + V+ A EG + G V
Sbjct: 307 FVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPAR 366
Query: 403 DRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTK 462
++ G ++ PT++T + ++ E F P+ V F +EEEV N VK GL++++++
Sbjct: 367 NQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSS 426
Query: 463 DLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTC 522
++GR+ R K G+V N E+ FGG K +G GRE D++ + T
Sbjct: 427 NVGRVHR--VAKKLQSGLVWTNCWLI-RELNLPFGGMKSSGIGREGAKDSYDFFTEIKTI 483
Query: 523 TINY 526
T+ +
Sbjct: 484 TVKH 487
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 179 bits (455), Expect = 4e-45
Identities = 133/498 (26%), Positives = 220/498 (44%), Gaps = 6/498 (1%)
Query: 21 PWSRPAAFMSTLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARV 80
P S PA + L + A L LR ++ G W PA+ + V
Sbjct: 33 PASGPAPGPAQLRCYAGRLAGLSAALLRTDS--FVGGRWLPAAATFPVQDPASGAALGMV 90
Query: 81 RQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKIL 140
V + V+ A EA+ W ++ A +R ++R+ + + + L +++ E GK L
Sbjct: 91 ADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPL 150
Query: 141 VEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAV 200
E GE+ ++ +R + G I+ + + P+G+ +IT +NFP A+
Sbjct: 151 KEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAM 210
Query: 201 YGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTA 260
A+ G + K A T ++A+ ++ ++ + + I ++G A
Sbjct: 211 ITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEA 270
Query: 261 MAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALF 320
+ D V+ +SFTGST GK + R +ELGG I F+ A++ V A+
Sbjct: 271 ICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMA 330
Query: 321 AAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQ-IRVGNPWDPNVLYGPLHTKQAVS 379
+ GQ C + + + IHD V +A + +RVGN ++ GPL ++AV
Sbjct: 331 SKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVE 390
Query: 380 MFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFK 439
V +A +G TVV GGK N+ EPT++ + D H ETF P+ V KF
Sbjct: 391 KVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFD 450
Query: 440 NEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGE 499
EEE A N GL+ +++D +I W + + G+V VN + + FGG
Sbjct: 451 TEEEAIAIANAADVGLAGYFYSQDPAQI--WRVAEQLEVGMVGVNEGLI-SSVECPFGGV 507
Query: 500 KHTGGGRESGSDAWKQYM 517
K +G GRE +Y+
Sbjct: 508 KQSGLGREGSKYGIDEYL 525
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 175 bits (443), Expect = 1e-43
Identities = 136/511 (26%), Positives = 223/511 (43%), Gaps = 19/511 (3%)
Query: 21 PWSRPAAFMSTLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARV 80
P S PA + L + A L LR ++ G W PA+ + V
Sbjct: 33 PASGPAPGPAQLRCYAGRLAGLSAALLRTDS--FVGGRWLPAAATFPVQDPASGAALGMV 90
Query: 81 RQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKIL 140
V + V+ A EA+ W ++ A +R ++R+ + + + L +++ E GK L
Sbjct: 91 ADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPL 150
Query: 141 VEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAV 200
E GE+ ++ +R + G I+ + + P+G+ +IT +NFP A+
Sbjct: 151 KEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAM 210
Query: 201 YGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNK---------LPGAICS-L 250
A+ G + K A T ++A+ ++ L D +P + + +
Sbjct: 211 ITRKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVI 270
Query: 251 TCG---GADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFE 307
C ++G A+ D V+ +SFTGST GK + R +ELGG I F+
Sbjct: 271 PCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFD 330
Query: 308 DADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQ-IRVGNPWDPN 366
A++ V A+ + GQ C + + + IHD V +A + +RVGN ++
Sbjct: 331 SANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEG 390
Query: 367 VLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHT 426
GPL ++AV V +A +G TVV GGK N+ EPT++ + D H
Sbjct: 391 TTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHE 450
Query: 427 ETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIP 486
ETF P+ V KF EEE A N GL+ +++D +I W + + G+V VN
Sbjct: 451 ETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQI--WRVAEQLEVGMVGVNEG 508
Query: 487 TSGAEIGGAFGGEKHTGGGRESGSDAWKQYM 517
+ + FGG K +G GRE +Y+
Sbjct: 509 LI-SSVECPFGGVKQSGLGREGSKYGIDEYL 538
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 155 bits (391), Expect = 1e-37
Identities = 113/430 (26%), Positives = 194/430 (45%), Gaps = 21/430 (4%)
Query: 66 ITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKI 125
I + PA NE I RV QA+ A+ + + + A+ WAD R +++ + ++E +
Sbjct: 57 IDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENL 116
Query: 126 QVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPV 185
+ + L++LE GK L + G+V + + ++A ++ ++ G +PS L P+
Sbjct: 117 KEIAKLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPL 176
Query: 186 GLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPG 245
G+ I FNFP + W +AM+CGN L K + T ++AK+L+D+ P
Sbjct: 177 GVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVP----GATMLLAKLLQDSGAPD 232
Query: 246 AICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIA 305
++ G + + + +SF GS + G+ + R +G N +
Sbjct: 233 GTLNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVV 292
Query: 306 FEDADLSLVVPSALFAAVGTAGQRC---TTARRLFIHESIHDEVVNRLKKAYAQIRVGNP 362
DA+ + + AA G AGQRC +TA + + E+V K +RV
Sbjct: 293 MPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAK----NLRVNAG 348
Query: 363 WDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMD----RPGNYVEPTIVTGLG 418
P GPL T QA ++ KEG +++ G+ + GN+V PTI++ +
Sbjct: 349 DQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVK 408
Query: 419 HDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKD--LGRIFRWLGPKGS 476
+ + E F P+L V + + +E N G ++IFT + R + L
Sbjct: 409 PNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHL----V 464
Query: 477 DCGIVNVNIP 486
D G V VN+P
Sbjct: 465 DVGQVGVNVP 474
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 135 bits (339), Expect = 1e-31
Identities = 115/485 (23%), Positives = 203/485 (41%), Gaps = 72/485 (14%)
Query: 52 EGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRG 111
E +G + I +Y P+ E RV + + E VK AREA+ W+ +R
Sbjct: 11 ENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERS 70
Query: 112 EIVRQIGDALREKIQVLGSLVSLEMGKIL-VEGVGEVQEYVDICDYAVGLSRMIGGPILP 170
++ Q+ D L + ++ S + GK L + ++ V + S
Sbjct: 71 RVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQ 130
Query: 171 SERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAV 230
+ G PVG+ G+I+ +N P+ + W A AM GN + K + TS+ +
Sbjct: 131 MDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAW-- 188
Query: 231 TKIIAKVLEDNKLPGAICSLTCG-GADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQER 289
++ K+L+ +P + ++ G G +G A+ V L+SFTGS +++ +
Sbjct: 189 --MLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPH 246
Query: 290 FGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNR 349
+ LELGG N I FEDA+L +P+ + S ++V +
Sbjct: 247 CKKLSLELGGKNPAIIFEDANLDECIPAT-------------------VRSSFANQVRSY 287
Query: 350 LKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDR----- 404
+K+A A+ G ++ G+ +D+
Sbjct: 288 VKRALAE------------------------------------GAQIWCGEGVDKLSLPA 311
Query: 405 ---PGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFT 461
G ++ PT++T + ++ E F P+ V F +EEEV N VK GL++++++
Sbjct: 312 RNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWS 371
Query: 462 KDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRST 521
++GR+ R K G+V N E+ FGG K +G GRE D++ + T
Sbjct: 372 SNVGRVHR--VAKKLQSGLVWTNCWLI-RELNLPFGGMKSSGIGREGAKDSYDFFTEIKT 428
Query: 522 CTINY 526
T+ +
Sbjct: 429 ITVKH 433
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 113 bits (283), Expect = 4e-25
Identities = 119/475 (25%), Positives = 204/475 (42%), Gaps = 41/475 (8%)
Query: 55 YNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIV 114
Y S G + +C A+ + + +A++A AR+ W + P R +I
Sbjct: 80 YQVSPFNHGHKVAKFCYADKSLLNKAIEAALA--------ARKEWDLK---PIADRAQIF 128
Query: 115 RQIGDALR--EKIQVLGSLVSLEMGKILVEG-VGEVQEYVDI----CDYAVGLSRMIGGP 167
+ D L + ++L + + GK +++ + E +D YAV L
Sbjct: 129 LKAADMLSGPRRAEILAKTM-VGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPIS 187
Query: 168 ILPSERSG-HALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLI 226
+ PS S + +E G V I+ FNF A+ G + GNV LWK + T L
Sbjct: 188 VPPSTNSTVYRGLE-----GFVAAISPFNF-TAIGGNLAGAPALMGNVVLWKPSDTAMLA 241
Query: 227 SVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMV 286
S AV +I+ E P I + G G + E + ++FTGS K + V
Sbjct: 242 SYAVYRILR---EAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQV 298
Query: 287 QER------FGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHE 340
+ F R E GG N AD+ VV L +A GQ+C+ RL++
Sbjct: 299 AQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPH 358
Query: 341 SIHDEVVNRLKKAYAQIRVGNP-WDPNVLYGPLHTKQAVSMFLGAVEEAKKEGG-TVVYG 398
S+ ++ RL + +++I+VG+P D + + ++ + +E A+ T++ G
Sbjct: 359 SLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAG 418
Query: 399 GKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKF---KNEEEVFAWNNEVKQGL 455
GK D G +VEP IV I E F P+L V+ + K +E + ++ GL
Sbjct: 419 GKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGL 478
Query: 456 SSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIG-GAFGGEKHTGGGRESG 509
+ ++F++D + + G +N ++G+ +G FGG + +G + G
Sbjct: 479 TGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 113 bits (283), Expect = 4e-25
Identities = 119/475 (25%), Positives = 204/475 (42%), Gaps = 41/475 (8%)
Query: 55 YNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIV 114
Y S G + +C A+ + + +A++A AR+ W + P R +I
Sbjct: 20 YQVSPFNHGHKVAKFCYADKSLLNKAIEAALA--------ARKEWDLK---PIADRAQIF 68
Query: 115 RQIGDALR--EKIQVLGSLVSLEMGKILVEG-VGEVQEYVDI----CDYAVGLSRMIGGP 167
+ D L + ++L + + GK +++ + E +D YAV L
Sbjct: 69 LKAADMLSGPRRAEILAKTM-VGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPIS 127
Query: 168 ILPSERSG-HALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLI 226
+ PS S + +E G V I+ FNF A+ G + GNV LWK + T L
Sbjct: 128 VPPSTNSTVYRGLE-----GFVAAISPFNF-TAIGGNLAGAPALMGNVVLWKPSDTAMLA 181
Query: 227 SVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMV 286
S AV +I+ E P I + G G + E + ++FTGS K + V
Sbjct: 182 SYAVYRILR---EAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQV 238
Query: 287 QER------FGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHE 340
+ F R E GG N AD+ VV L +A GQ+C+ RL++
Sbjct: 239 AQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPH 298
Query: 341 SIHDEVVNRLKKAYAQIRVGNP-WDPNVLYGPLHTKQAVSMFLGAVEEAKKEGG-TVVYG 398
S+ ++ RL + +++I+VG+P D + + ++ + +E A+ T++ G
Sbjct: 299 SLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAG 358
Query: 399 GKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKF---KNEEEVFAWNNEVKQGL 455
GK D G +VEP IV I E F P+L V+ + K +E + ++ GL
Sbjct: 359 GKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGL 418
Query: 456 SSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIG-GAFGGEKHTGGGRESG 509
+ ++F++D + + G +N ++G+ +G FGG + +G + G
Sbjct: 419 TGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 473
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 113 bits (283), Expect = 4e-25
Identities = 119/475 (25%), Positives = 204/475 (42%), Gaps = 41/475 (8%)
Query: 55 YNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIV 114
Y S G + +C A+ + + +A++A AR+ W + P R +I
Sbjct: 80 YQVSPFNHGHKVAKFCYADKSLLNKAIEAALA--------ARKEWDLK---PIADRAQIF 128
Query: 115 RQIGDALR--EKIQVLGSLVSLEMGKILVEG-VGEVQEYVDI----CDYAVGLSRMIGGP 167
+ D L + ++L + + GK +++ + E +D YAV L
Sbjct: 129 LKAADMLSGPRRAEILAKTM-VGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPIS 187
Query: 168 ILPSERSG-HALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLI 226
+ PS S + +E G V I+ FNF A+ G + GNV LWK + T L
Sbjct: 188 VPPSTNSTVYRGLE-----GFVAAISPFNF-TAIGGNLAGAPALMGNVVLWKPSDTAMLA 241
Query: 227 SVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMV 286
S AV +I+ E P I + G G + E + ++FTGS K + V
Sbjct: 242 SYAVYRILR---EAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQV 298
Query: 287 QER------FGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHE 340
+ F R E GG N AD+ VV L +A GQ+C+ RL++
Sbjct: 299 AQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPH 358
Query: 341 SIHDEVVNRLKKAYAQIRVGNP-WDPNVLYGPLHTKQAVSMFLGAVEEAKKEGG-TVVYG 398
S+ ++ RL + +++I+VG+P D + + ++ + +E A+ T++ G
Sbjct: 359 SLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAG 418
Query: 399 GKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKF---KNEEEVFAWNNEVKQGL 455
GK D G +VEP IV I E F P+L V+ + K +E + ++ GL
Sbjct: 419 GKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGL 478
Query: 456 SSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIG-GAFGGEKHTGGGRESG 509
+ ++F++D + + G +N ++G+ +G FGG + +G + G
Sbjct: 479 TGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 100 bits (248), Expect = 4e-21
Identities = 118/479 (24%), Positives = 200/479 (41%), Gaps = 49/479 (10%)
Query: 56 NGSWGGRGEVITTYC--PANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEI 113
NG W + C P E +A QA D V+ AR A+K W+ P R +
Sbjct: 45 NGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQH 104
Query: 114 VRQIGDALREKIQVLGSLVSLEMGKILVE-GVGEVQEYVDICDYAVGLSRMIGGPILPSE 172
+ ++ + +++ ++L +L SL G+ + E G+VQ + Y + +
Sbjct: 105 LTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA----------IQAS 154
Query: 173 RSGHALIEQWNPVGLVGIITAFNFPVAVYGWN--NAIAMICGNVCLWKGAPTTSLISVAV 230
AL W P+G++G+I F W A+A+ C V L P S + +
Sbjct: 155 TQEEALAG-WEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVAL---VPPASPAPLLL 210
Query: 231 TKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERF 290
++ ++ PG I ++ G A + +A + ++F G+ + G+ + +
Sbjct: 211 AQLAGEL---GPFPG-ILNVLSGPASLVPILASQPGIRKVAFCGAPEEGRALRRSLAGEC 266
Query: 291 GRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRL 350
L LG + ++ + AD+ V + AA G RL I ES+ DE + RL
Sbjct: 267 AELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPG---GLRLLIQESVWDEAMRRL 323
Query: 351 KKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKV-MDRPGNYV 409
++ ++R G D V G A + V EA+ +G V G V +RP +
Sbjct: 324 QERMGRLRSGRGLDGAVDMGA-RGAAACDLVQRFVREAQSQGAQVFQAGDVPSERP--FY 380
Query: 410 EPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFR 469
PT+V+ L + A E P++ F+ +E N +G S+S++++ LG+
Sbjct: 381 PPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALE 440
Query: 470 WLGPKGSDCGIVNVN--------IPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRS 520
LG G G V +N +PT GG K +G G D +Y+R S
Sbjct: 441 -LG-YGLQVGTVWINAHGLRDPSVPT---------GGCKESGCSWHGGPDGLYEYLRPS 488
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 92.0 bits (227), Expect = 1e-18
Identities = 78/341 (22%), Positives = 153/341 (44%), Gaps = 14/341 (4%)
Query: 184 PVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKL 243
P+G+V +I +N+P + A+ GN + K + + ++ + II + L+ +
Sbjct: 104 PLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLY 163
Query: 244 PGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAI 303
P + GG T + K ER + + +TGST VGK + + LELGG +
Sbjct: 164 P-----VINGGVPETTELLK-ERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPC 217
Query: 304 IAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPW 363
++ DL + + +GQ C + SI +++V +LKK+ + G
Sbjct: 218 YVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDA 276
Query: 364 DPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASI 423
+ YG + + + +G + EG V YGG D Y+ PTI+T + + +
Sbjct: 277 KKSRDYGRIISARHFQRVMGLI-----EGQKVAYGG-TGDAATRYIAPTILTDVDPQSPV 330
Query: 424 AHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNV 483
E F P+L + ++ EE + N+ ++ L+ +F+ + ++ + + + S G+
Sbjct: 331 MQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSN-DKVIKKMIAETSSGGVAAN 389
Query: 484 NIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
++ FGG ++G G G +++ + R +C +
Sbjct: 390 DVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLV 430
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 92.0 bits (227), Expect = 1e-18
Identities = 78/341 (22%), Positives = 153/341 (44%), Gaps = 14/341 (4%)
Query: 184 PVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKL 243
P+G+V +I +N+P + A+ GN + K + + ++ + II + L+ +
Sbjct: 104 PLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLY 163
Query: 244 PGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAI 303
P + GG T + K ER + + +TGST VGK + + LELGG +
Sbjct: 164 P-----VINGGVPETTELLK-ERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPC 217
Query: 304 IAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPW 363
++ DL + + +GQ C + SI +++V +LKK+ + G
Sbjct: 218 YVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDA 276
Query: 364 DPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASI 423
+ YG + + + +G + EG V YGG D Y+ PTI+T + + +
Sbjct: 277 KKSRDYGRIISARHFQRVMGLI-----EGQKVAYGG-TGDAATRYIAPTILTDVDPQSPV 330
Query: 424 AHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNV 483
E F P+L + ++ EE + N+ ++ L+ +F+ + ++ + + + S G+
Sbjct: 331 MQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSN-DKVIKKMIAETSSGGVAAN 389
Query: 484 NIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
++ FGG ++G G G +++ + R +C +
Sbjct: 390 DVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLV 430
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 92.0 bits (227), Expect = 1e-18
Identities = 78/341 (22%), Positives = 153/341 (44%), Gaps = 14/341 (4%)
Query: 184 PVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKL 243
P+G+V +I +N+P + A+ GN + K + + ++ + II + L+ +
Sbjct: 104 PLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLY 163
Query: 244 PGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAI 303
P + GG T + K ER + + +TGST VGK + + LELGG +
Sbjct: 164 P-----VINGGVPETTELLK-ERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPC 217
Query: 304 IAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPW 363
++ DL + + +GQ C + SI +++V +LKK+ + G
Sbjct: 218 YVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDA 276
Query: 364 DPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASI 423
+ YG + + + +G + EG V YGG D Y+ PTI+T + + +
Sbjct: 277 KKSRDYGRIISARHFQRVMGLI-----EGQKVAYGG-TGDAATRYIAPTILTDVDPQSPV 330
Query: 424 AHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNV 483
E F P+L + ++ EE + N+ ++ L+ +F+ + ++ + + + S G+
Sbjct: 331 MQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSN-DKVIKKMIAETSSGGVAAN 389
Query: 484 NIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
++ FGG ++G G G +++ + R +C +
Sbjct: 390 DVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLV 430
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 90.9 bits (224), Expect = 3e-18
Identities = 85/351 (24%), Positives = 150/351 (42%), Gaps = 20/351 (5%)
Query: 181 QWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLED 240
Q P+G+V II A+N+P + A+ GN + K S +S KI+AK+L
Sbjct: 98 QPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIK----PSELSENTAKILAKLLPQ 153
Query: 241 NKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGN 300
L + + GG + T + K +R + + +TG+T VGK V + LELGG
Sbjct: 154 Y-LDQDLYIVINGGVEETTELLK-QRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGK 211
Query: 301 NAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQI--- 357
+ +D DL +V + GQ C + S+ +++V ++K+ +
Sbjct: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGE 271
Query: 358 RVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGL 417
+ D + H K+ +S+ EG + +GG+ D Y+ PT++T +
Sbjct: 272 NIKESPDYERIINLRHFKRILSLL---------EGQKIAFGGET-DEATRYIAPTVLTDV 321
Query: 418 GHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSD 477
+ E F PIL + KN +E + NE ++ L+ +F+ + I R + S
Sbjct: 322 DPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSG 381
Query: 478 CGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSK 528
G+ ++ FGG +G G G ++ + + C + K
Sbjct: 382 -GVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLK 431
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 90.9 bits (224), Expect = 3e-18
Identities = 85/351 (24%), Positives = 150/351 (42%), Gaps = 20/351 (5%)
Query: 181 QWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLED 240
Q P+G+V II A+N+P + A+ GN + K S +S KI+AK+L
Sbjct: 98 QPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIK----PSELSENTAKILAKLLPQ 153
Query: 241 NKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGN 300
L + + GG + T + K +R + + +TG+T VGK V + LELGG
Sbjct: 154 Y-LDQDLYIVINGGVEETTELLK-QRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGK 211
Query: 301 NAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQI--- 357
+ +D DL +V + GQ C + S+ +++V ++K+ +
Sbjct: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGE 271
Query: 358 RVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGL 417
+ D + H K+ +S+ EG + +GG+ D Y+ PT++T +
Sbjct: 272 NIKESPDYERIINLRHFKRILSLL---------EGQKIAFGGET-DEATRYIAPTVLTDV 321
Query: 418 GHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSD 477
+ E F PIL + KN +E + NE ++ L+ +F+ + I R + S
Sbjct: 322 DPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSG 381
Query: 478 CGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSK 528
G+ ++ FGG +G G G ++ + + C + K
Sbjct: 382 -GVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLK 431
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 80.9 bits (198), Expect = 3e-15
Identities = 108/450 (24%), Positives = 180/450 (40%), Gaps = 40/450 (8%)
Query: 90 ETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQE 149
+T+++ REA+ PA R ++ +G L+E Q+L ++ ++ K E EV E
Sbjct: 6 DTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFES--EVSE 63
Query: 150 YVDICDYAVGLSRMIGGPILPSERSGHALIEQWN-------PVGLVGIITAFNFPVAVYG 202
V I V L+ + ER L Q + P GLV II +N+P+ +
Sbjct: 64 -VAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTL 122
Query: 203 WNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMA 262
A+ GN + K S IS V KI+A+VL + C G T
Sbjct: 123 VPLVGALAAGNCVVLK----PSEISKNVEKILAEVLP--QYVDQSCFAVVLGGPQETGQL 176
Query: 263 KDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAA 322
+ R + + FTGS +VGK V + LELGG N ++ D V +
Sbjct: 177 LEHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFR 236
Query: 323 VGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTK--QAVSM 380
AGQ C + + + ++ L+ + +P L ++ K Q +
Sbjct: 237 YFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRA 296
Query: 381 FLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKN 440
LG G V GG+ D Y+ PT++ + + E F PIL + ++
Sbjct: 297 LLGC--------GRVAIGGQ-SDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQS 347
Query: 441 EEEVFAWNNEVKQGLSSSIFTKDLGRIFRWL------GPKGSDCGIVNVNIPTSGAEIGG 494
+E + N ++ L+ F+ + R L G G+D G +++ + +
Sbjct: 348 LDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGND-GFMHMTLASL------ 400
Query: 495 AFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
FGG +G GR G ++ + C +
Sbjct: 401 PFGGVGASGMGRYHGKFSFDTFSHHRACLL 430
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 80.9 bits (198), Expect = 3e-15
Identities = 108/450 (24%), Positives = 180/450 (40%), Gaps = 40/450 (8%)
Query: 90 ETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQE 149
+T+++ REA+ PA R ++ +G L+E Q+L ++ ++ K E EV E
Sbjct: 6 DTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFES--EVSE 63
Query: 150 YVDICDYAVGLSRMIGGPILPSERSGHALIEQWN-------PVGLVGIITAFNFPVAVYG 202
V I V L+ + ER L Q + P GLV II +N+P+ +
Sbjct: 64 -VAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTL 122
Query: 203 WNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMA 262
A+ GN + K S IS V KI+A+VL + C G T
Sbjct: 123 VPLVGALAAGNCVVLK----PSEISKNVEKILAEVLP--QYVDQSCFAVVLGGPQETGQL 176
Query: 263 KDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAA 322
+ R + + FTGS +VGK V + LELGG N ++ D V +
Sbjct: 177 LEHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFR 236
Query: 323 VGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTK--QAVSM 380
AGQ C + + + ++ L+ + +P L ++ K Q +
Sbjct: 237 YFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRA 296
Query: 381 FLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKN 440
LG G V GG+ D Y+ PT++ + + E F PIL + ++
Sbjct: 297 LLGC--------GRVAIGGQ-SDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQS 347
Query: 441 EEEVFAWNNEVKQGLSSSIFTKDLGRIFRWL------GPKGSDCGIVNVNIPTSGAEIGG 494
+E + N ++ L+ F+ + R L G G+D G +++ + +
Sbjct: 348 LDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGND-GFMHMTLASL------ 400
Query: 495 AFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
FGG +G GR G ++ + C +
Sbjct: 401 PFGGVGASGMGRYHGKFSFDTFSHHRACLL 430
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 75.1 bits (183), Expect = 2e-13
Identities = 79/348 (22%), Positives = 140/348 (40%), Gaps = 28/348 (8%)
Query: 184 PVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKL 243
P GLV II +N+P+ + A+ G+ + K S IS K++A+VL L
Sbjct: 23 PFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLK----PSEISQGTEKVLAEVLPQY-L 77
Query: 244 PGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAI 303
+ ++ GG T + +++ + FTGS +VGK V + LELGG N
Sbjct: 78 DQSCFAVVLGGPQ-ETGQLLEHKLDYIFFTGSPRVGKIVMTAATKHLTPVTLELGGKNPC 136
Query: 304 IAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPW 363
++ D V + AGQ C + + + ++ L+ + +P
Sbjct: 137 YVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQ 196
Query: 364 DPNVLYGPLHTK--QAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDA 421
L ++ K Q + LG G V GG+ + Y+ PT++ +
Sbjct: 197 SSPNLGRIINQKQFQRLRALLGC--------GRVAIGGQ-SNESDRYIAPTVLVDVQETE 247
Query: 422 SIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWL-----GPKGS 476
+ E F PIL + ++ +E + N ++ L+ F+ + + L G G
Sbjct: 248 PVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGSFGG 307
Query: 477 DCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
+ G +++ + FGG H+G GR G + + TC +
Sbjct: 308 NEGFTYISL------LSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLL 349
>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 75.1 bits (183), Expect = 2e-13
Identities = 79/348 (22%), Positives = 140/348 (40%), Gaps = 28/348 (8%)
Query: 184 PVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKL 243
P GLV II +N+P+ + A+ G+ + K S IS K++A+VL L
Sbjct: 23 PFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLK----PSEISQGTEKVLAEVLPQY-L 77
Query: 244 PGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAI 303
+ ++ GG T + +++ + FTGS +VGK V + LELGG N
Sbjct: 78 DQSCFAVVLGGPQ-ETGQLLEHKLDYIFFTGSPRVGKIVMTAATKHLTPVTLELGGKNPC 136
Query: 304 IAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPW 363
++ D V + AGQ C + + + ++ L+ + +P
Sbjct: 137 YVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQ 196
Query: 364 DPNVLYGPLHTK--QAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDA 421
L ++ K Q + LG G V GG+ + Y+ PT++ +
Sbjct: 197 SSPNLGRIINQKQFQRLRALLGC--------GRVAIGGQ-SNESDRYIAPTVLVDVQETE 247
Query: 422 SIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWL-----GPKGS 476
+ E F PIL + ++ +E + N ++ L+ F+ + + L G G
Sbjct: 248 PVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGSFGG 307
Query: 477 DCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
+ G +++ + FGG H+G GR G + + TC +
Sbjct: 308 NEGFTYISL------LSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLL 349
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 72.0 bits (175), Expect = 1e-12
Identities = 98/443 (22%), Positives = 170/443 (38%), Gaps = 63/443 (14%)
Query: 90 ETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQE 149
+T+++ REA+ PA R ++ +G L+E Q+L ++ ++ K
Sbjct: 6 DTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHK----------- 54
Query: 150 YVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAM 209
+ + A I + P GLV II +N+P+ + A+
Sbjct: 55 ---------------------ATQLDSAFIRK-EPFGLVLIIAPWNYPLNLTLVPLVGAL 92
Query: 210 ICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNL 269
GN + K S IS V KI+A+VL + C G T + R +
Sbjct: 93 AAGNCVVLK----PSEISKNVEKILAEVLP--QYVDQSCFAVVLGGPQETGQLLEHRFDY 146
Query: 270 LSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQR 329
+ FTGS +VGK V + LELGG N ++ D V + AGQ
Sbjct: 147 IFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQT 206
Query: 330 CTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTK--QAVSMFLGAVEE 387
C + + + ++ L+ + +P L ++ K Q + LG
Sbjct: 207 CVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC--- 263
Query: 388 AKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAW 447
G V GG+ D Y+ PT++ + + E F PIL + ++ +E +
Sbjct: 264 -----GRVAIGGQ-SDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEF 317
Query: 448 NNEVKQGLSSSIFTKDLGRIFRWL------GPKGSDCGIVNVNIPTSGAEIGGAFGGEKH 501
N ++ L+ F+ + R L G G+D G +++ + + FGG
Sbjct: 318 INRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGND-GFMHMTLASL------PFGGVGA 370
Query: 502 TGGGRESGSDAWKQYMRRSTCTI 524
+G GR G ++ + C +
Sbjct: 371 SGMGRYHGKFSFDTFSHHRACLL 393
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,113,505
Number of Sequences: 37866
Number of extensions: 973565
Number of successful extensions: 2244
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 2118
Number of HSP's gapped (non-prelim): 60
length of query: 539
length of database: 18,247,518
effective HSP length: 107
effective length of query: 432
effective length of database: 14,195,856
effective search space: 6132609792
effective search space used: 6132609792
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.