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Search of human proteins with 104487611
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
(1505 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 3067 0.0
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 3054 0.0
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 2352 0.0
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 2338 0.0
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 1912 0.0
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 1897 0.0
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 1541 0.0
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 1541 0.0
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 1541 0.0
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 1407 0.0
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 1405 0.0
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 592 e-168
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 589 e-168
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 589 e-168
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor... 552 e-157
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo... 549 e-156
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 521 e-147
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 514 e-145
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 506 e-143
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 498 e-140
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 498 e-140
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 473 e-133
gi|110735404 protein tyrosine phosphatase, receptor type, U isof... 462 e-129
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 456 e-128
gi|110735406 protein tyrosine phosphatase, receptor type, U isof... 456 e-127
gi|110735402 protein tyrosine phosphatase, receptor type, U isof... 445 e-124
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 412 e-114
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 397 e-110
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 397 e-110
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 397 e-110
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 3067 bits (7952), Expect = 0.0
Identities = 1505/1505 (100%), Positives = 1505/1505 (100%)
Query: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP
Sbjct: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
Query: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA
Sbjct: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
Query: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS
Sbjct: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
Query: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSI 240
NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSI
Sbjct: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSI 240
Query: 241 LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY 300
LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY
Sbjct: 241 LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY 300
Query: 301 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 360
TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS
Sbjct: 301 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 360
Query: 361 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 420
KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA
Sbjct: 361 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 420
Query: 421 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 480
PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG
Sbjct: 421 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 480
Query: 481 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR 540
SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR
Sbjct: 481 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR 540
Query: 541 QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV 600
QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV
Sbjct: 541 QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV 600
Query: 601 RQRTLQSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLIT 660
RQRTLQSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLIT
Sbjct: 601 RQRTLQSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLIT 660
Query: 661 HLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQS 720
HLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQS
Sbjct: 661 HLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQS 720
Query: 721 PVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRP 780
PVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRP
Sbjct: 721 PVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRP 780
Query: 781 YIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQ 840
YIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQ
Sbjct: 781 YIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQ 840
Query: 841 LDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN 900
LDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN
Sbjct: 841 LDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN 900
Query: 901 ADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG 960
ADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG
Sbjct: 901 ADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG 960
Query: 961 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIA 1020
QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIA
Sbjct: 961 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIA 1020
Query: 1021 TQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDT 1080
TQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDT
Sbjct: 1021 TQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDT 1080
Query: 1081 IELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG 1140
IELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG
Sbjct: 1081 IELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG 1140
Query: 1141 PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHE 1200
PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHE
Sbjct: 1141 PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHE 1200
Query: 1201 ALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLP 1260
ALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLP
Sbjct: 1201 ALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLP 1260
Query: 1261 CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1320
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED
Sbjct: 1261 CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1320
Query: 1321 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1380
FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF
Sbjct: 1321 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1380
Query: 1381 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAG 1440
KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAG
Sbjct: 1381 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAG 1440
Query: 1441 VGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSF 1500
VGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSF
Sbjct: 1441 VGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSF 1500
Query: 1501 DHYAT 1505
DHYAT
Sbjct: 1501 DHYAT 1505
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 3054 bits (7918), Expect = 0.0
Identities = 1501/1505 (99%), Positives = 1501/1505 (99%), Gaps = 4/1505 (0%)
Query: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP
Sbjct: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
Query: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA
Sbjct: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
Query: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS
Sbjct: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
Query: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSI 240
NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVR VRRVAPRFSI
Sbjct: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSI 236
Query: 241 LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY 300
LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY
Sbjct: 237 LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY 296
Query: 301 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 360
TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS
Sbjct: 297 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 356
Query: 361 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 420
KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA
Sbjct: 357 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 416
Query: 421 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 480
PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG
Sbjct: 417 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 476
Query: 481 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR 540
SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR
Sbjct: 477 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR 536
Query: 541 QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV 600
QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV
Sbjct: 537 QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV 596
Query: 601 RQRTLQSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLIT 660
RQRTLQSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLIT
Sbjct: 597 RQRTLQSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLIT 656
Query: 661 HLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQS 720
HLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQS
Sbjct: 657 HLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQS 716
Query: 721 PVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRP 780
PVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRP
Sbjct: 717 PVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRP 776
Query: 781 YIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQ 840
YIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQ
Sbjct: 777 YIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQ 836
Query: 841 LDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN 900
LDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN
Sbjct: 837 LDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN 896
Query: 901 ADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG 960
ADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG
Sbjct: 897 ADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG 956
Query: 961 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIA 1020
QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIA
Sbjct: 957 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIA 1016
Query: 1021 TQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDT 1080
TQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDT
Sbjct: 1017 TQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDT 1076
Query: 1081 IELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG 1140
IELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG
Sbjct: 1077 IELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG 1136
Query: 1141 PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHE 1200
PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHE
Sbjct: 1137 PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHE 1196
Query: 1201 ALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLP 1260
ALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLP
Sbjct: 1197 ALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLP 1256
Query: 1261 CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1320
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED
Sbjct: 1257 CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1316
Query: 1321 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1380
FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF
Sbjct: 1317 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1376
Query: 1381 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAG 1440
KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAG
Sbjct: 1377 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAG 1436
Query: 1441 VGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSF 1500
VGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSF
Sbjct: 1437 VGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSF 1496
Query: 1501 DHYAT 1505
DHYAT
Sbjct: 1497 DHYAT 1501
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 2352 bits (6094), Expect = 0.0
Identities = 1142/1486 (76%), Positives = 1304/1486 (87%), Gaps = 12/1486 (0%)
Query: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
Query: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
Query: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSG------ALQIESSEETDQ 202
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRSG ALQIE SEE+DQ
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSEESDQ 199
Query: 203 GKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGS 262
GKYECVATNSAG RYS+PANLYVRELREVRRV PRFSI P +HEIMPGG+VNITCVAVGS
Sbjct: 200 GKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGS 259
Query: 263 PMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSL 322
PMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITVK+L
Sbjct: 260 PMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKAL 319
Query: 323 PKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGG 382
PK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS+ G
Sbjct: 320 PKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAG 379
Query: 383 LSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV 442
LSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+EP
Sbjct: 380 LSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPE 439
Query: 443 EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 502
EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+GDGP
Sbjct: 440 EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGP 499
Query: 503 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGR 562
LS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 500 LSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRI 559
Query: 563 TFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTS 622
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+QS+ KNF VK +MKTS
Sbjct: 560 TIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTS 619
Query: 623 VLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLG 680
VLLSWE P+NYNS P+KI Y+ + +VDGR T+KLI +LKP Y+FVLTNRG+S G
Sbjct: 620 VLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAG 679
Query: 681 GLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGG 740
GLQ VTA TA ++L KP+ K + DG I V LP+ + ++ Y+I++VPL+KSRG
Sbjct: 680 GLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRG- 738
Query: 741 QFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQ 800
+F+ P SP++M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP F GD K
Sbjct: 739 KFIKPWESPDEMELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKH 796
Query: 801 YGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWV 859
YGGF N+ L+ G YV FVLAV++ +E +A SP+SDP + DPQPI D EEGLIWV
Sbjct: 797 YGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWV 856
Query: 860 IGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINF 919
+GPVLAVVFIICIVIAILLYK+KPD KR +S+ R + NN ++ HHP DPVE+RR+NF
Sbjct: 857 VGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNF 916
Query: 920 QTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRY 979
QTPGM SHPPIPI ++A+H ERLKAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRY
Sbjct: 917 QTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRY 976
Query: 980 ANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQ 1039
ANVIAYDHSRV+L IEGI GSDY+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQ
Sbjct: 977 ANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQ 1036
Query: 1040 RSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSS 1099
RSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSS
Sbjct: 1037 RSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSS 1096
Query: 1100 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1159
EKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVI
Sbjct: 1097 EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVI 1156
Query: 1160 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1219
DAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LY
Sbjct: 1157 DAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLY 1216
Query: 1220 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1279
AYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRV
Sbjct: 1217 AYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1276
Query: 1280 CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKL 1339
CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKL
Sbjct: 1277 CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKL 1336
Query: 1340 REMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1399
REMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT
Sbjct: 1337 REMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1396
Query: 1400 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1459
DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY
Sbjct: 1397 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1456
Query: 1460 EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1505
EGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1457 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1502
Score = 95.5 bits (236), Expect = 3e-19
Identities = 113/470 (24%), Positives = 188/470 (40%), Gaps = 87/470 (18%)
Query: 228 LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 279
LR PRF+ P+ + GG + C A G P P + W Q E + +
Sbjct: 16 LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75
Query: 280 DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 330
D + L +D A Y CVA +++G I ++TV + P G P
Sbjct: 76 DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135
Query: 331 VTENTATSITITWDSGNPDP-VSYY-----------------------------VIEYKS 360
V E T T+ + SGNPDP ++++ IE
Sbjct: 136 VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSE 195
Query: 361 KSQDGPYQ-IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPAS 419
+S G Y+ + + TRYS + ++V + + + PP S+ E P
Sbjct: 196 ESDQGKYECVATNSAGTRYS-------APANLYVRELREVRRVPPRFSIPPTNHEIMPGG 248
Query: 420 APRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTV 479
+ N+ + + V+W E T E + P+G NV +
Sbjct: 249 SV-NITCVAVGSPMPYVKWMLGAED----------LTPEDDMPIG----RNV-----LEL 288
Query: 480 GSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPP 539
+ + YT +A +++G I VK PG P+ + A TSITL+W
Sbjct: 289 NDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTWDSG 343
Query: 540 RQESIIKYELLFREGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLG-AF 596
E + Y ++ + + E+ + D TT Y V L P ++Y FR+ A + G G
Sbjct: 344 NPEP-VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPS 402
Query: 597 TPVVRQRTLQ--SISPKNFKVKMIMKTSVLLSWEFPDNYNSPTP-YKIQY 643
PV+ Q + Q S +P++ + +M+ T++L+ W+ P+ N Y++ Y
Sbjct: 403 EPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY 452
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 2338 bits (6058), Expect = 0.0
Identities = 1139/1489 (76%), Positives = 1300/1489 (87%), Gaps = 19/1489 (1%)
Query: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
Query: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
Query: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS---------GALQIESSEE 199
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS GALQIE SEE
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
Query: 200 TDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVA 259
+DQGKYECVATNSAG RYS+PANLYVRELREVRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
Query: 260 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 319
VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319
Query: 320 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 379
K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS
Sbjct: 320 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379
Query: 380 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 439
+ GLSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 380 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439
Query: 440 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 499
EP EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+G
Sbjct: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
Query: 500 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 559
DGPLS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559
Query: 560 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIM 619
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+QS+ KNF VK +M
Sbjct: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVM 619
Query: 620 KTSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGS 677
KTSVLLSWE P+NYNS P+KI Y+ + +VDGR T+KLI +LKP Y+FVLTNRG+
Sbjct: 620 KTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGN 679
Query: 678 SLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKS 737
S GGLQ VTA TA ++L KP+ K + DG I V LP+ + ++ Y+I++VPL+KS
Sbjct: 680 SAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKS 739
Query: 738 RGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGD 797
RG +F+ P SP++M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP F GD
Sbjct: 740 RG-KFIKPWESPDEMELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGD 796
Query: 798 QKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGL 856
K YGGF N+ L+ G YV FVLAV++ +E +A SP+SDP + DPQPI D EEGL
Sbjct: 797 DKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGL 856
Query: 857 IWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRR 916
IWV+GPVLAVVFIICIVIAILLYK K R +S+ R + NN ++ HHP DPVE+RR
Sbjct: 857 IWVVGPVLAVVFIICIVIAILLYKRK----RAESDSRKSSIPNNKEIPSHHPTDPVELRR 912
Query: 917 INFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPK 976
+NFQTPGM SHPPIPI ++A+H ERLKAND+LK SQEYESIDPGQQFTWEHSNLEVNKPK
Sbjct: 913 LNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPK 972
Query: 977 NRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMV 1036
NRYANVIAYDHSRV+L IEGI GSDY+NANY+DGYR QNAYIATQG LPETFGDFWRM+
Sbjct: 973 NRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMI 1032
Query: 1037 WEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKN 1096
WEQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KN
Sbjct: 1033 WEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKN 1092
Query: 1097 GSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCF 1156
GSSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCF
Sbjct: 1093 GSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCF 1152
Query: 1157 IVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPAR 1216
IVIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR
Sbjct: 1153 IVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPAR 1212
Query: 1217 SLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYES 1276
+LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFISANLPCNKFKNRLVNIMPYES
Sbjct: 1213 NLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYES 1272
Query: 1277 TRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVML 1336
TRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE+NSTIVVML
Sbjct: 1273 TRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVML 1332
Query: 1337 TKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQF 1396
TKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQF
Sbjct: 1333 TKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQF 1392
Query: 1397 QFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLER 1456
QFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLER
Sbjct: 1393 QFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLER 1452
Query: 1457 MRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1505
MRYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1453 MRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1501
Score = 94.4 bits (233), Expect = 8e-19
Identities = 113/473 (23%), Positives = 188/473 (39%), Gaps = 90/473 (19%)
Query: 228 LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 279
LR PRF+ P+ + GG + C A G P P + W Q E + +
Sbjct: 16 LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75
Query: 280 DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 330
D + L +D A Y CVA +++G I ++TV + P G P
Sbjct: 76 DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135
Query: 331 VTENTATSITITWDSGNPDP-VSYY--------------------------------VIE 357
V E T T+ + SGNPDP ++++ IE
Sbjct: 136 VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIE 195
Query: 358 YKSKSQDGPYQ-IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQA 416
+S G Y+ + + TRYS + ++V + + + PP S+ E
Sbjct: 196 QSEESDQGKYECVATNSAGTRYS-------APANLYVRELREVRRVPPRFSIPPTNHEIM 248
Query: 417 PASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLL 476
P + N+ + + V+W E T E + P+G NV
Sbjct: 249 PGGSV-NITCVAVGSPMPYVKWMLGAED----------LTPEDDMPIG----RNV----- 288
Query: 477 TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSW 536
+ + + YT +A +++G I VK PG P+ + A TSITL+W
Sbjct: 289 LELNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTW 343
Query: 537 SPPRQESIIKYELLFREGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLG 594
E + Y ++ + + E+ + D TT Y V L P ++Y FR+ A + G G
Sbjct: 344 DSGNPEP-VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRG 402
Query: 595 -AFTPVVRQRTLQ--SISPKNFKVKMIMKTSVLLSWEFPDNYNSPTP-YKIQY 643
PV+ Q + Q S +P++ + +M+ T++L+ W+ P+ N Y++ Y
Sbjct: 403 PPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY 455
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 1912 bits (4952), Expect = 0.0
Identities = 985/1266 (77%), Positives = 1047/1266 (82%), Gaps = 36/1266 (2%)
Query: 272 GAEDLTPED--DMPVGRNVLELTDVKDSANY--TCVAMSSLGVIEAVAQITVKS---LPK 324
G+ED P++ +P + L ++ Y T VA + +G + + V++ +P
Sbjct: 649 GSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPS 708
Query: 325 APGTPMVTEN-TATSITITWDSGNPD----PVSYYVIEY---KSKSQDGPYQIKEDITTT 376
AP + E AT+I + W S P + Y + Y + GP +IK+ +
Sbjct: 709 APPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLAD 768
Query: 377 RYS--IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTM 434
I L P + Y I V+A G G S+ V T +VQ ++
Sbjct: 769 AQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQ--QTPEGSL 826
Query: 435 IVQWEEPV-EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVL 493
+ +WE P + GYR+ + E P+ + +D T + + TY R+
Sbjct: 827 LARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRY--TASGVHKGATYVFRLA 884
Query: 494 AFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET-SITLSWSPP----RQESIIKYE 548
A + G G + + + G P L A + ++ L W PP R +I+KY
Sbjct: 885 ARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYT 944
Query: 549 LLFREGD-----HGREVGRTFDP--TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVR 601
+ RE E+ +P + ++ LKP+T Y ++ A + +G G F+P VR
Sbjct: 945 VAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVR 1004
Query: 602 QRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLI 659
RT +SPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLI
Sbjct: 1005 YRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLI 1064
Query: 660 THLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQ 719
THLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQ
Sbjct: 1065 THLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQ 1124
Query: 720 SPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPR 779
SPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPR
Sbjct: 1125 SPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPR 1184
Query: 780 PYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPF 839
PYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPF
Sbjct: 1185 PYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPF 1244
Query: 840 QLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLN 899
QLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLN
Sbjct: 1245 QLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLN 1304
Query: 900 NADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDP 959
NADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDP
Sbjct: 1305 NADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDP 1364
Query: 960 GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYI 1019
GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYI
Sbjct: 1365 GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYI 1424
Query: 1020 ATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLD 1079
ATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLD
Sbjct: 1425 ATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLD 1484
Query: 1080 TIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDA 1139
TIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDA
Sbjct: 1485 TIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDA 1544
Query: 1140 GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIH 1199
GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIH
Sbjct: 1545 GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIH 1604
Query: 1200 EALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANL 1259
EALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANL
Sbjct: 1605 EALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANL 1664
Query: 1260 PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTE 1319
PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTE
Sbjct: 1665 PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTE 1724
Query: 1320 DFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILRE 1379
DFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILRE
Sbjct: 1725 DFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILRE 1784
Query: 1380 FKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA 1439
FKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA
Sbjct: 1785 FKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA 1844
Query: 1440 GVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1499
GVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS
Sbjct: 1845 GVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1904
Query: 1500 FDHYAT 1505
FDHYAT
Sbjct: 1905 FDHYAT 1910
Score = 1221 bits (3160), Expect = 0.0
Identities = 614/652 (94%), Positives = 624/652 (95%), Gaps = 10/652 (1%)
Query: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP
Sbjct: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
Query: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA
Sbjct: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
Query: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS
Sbjct: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
Query: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSI 240
NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVR VRRVAPRFSI
Sbjct: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSI 236
Query: 241 LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY 300
LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY
Sbjct: 237 LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY 296
Query: 301 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 360
TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS
Sbjct: 297 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 356
Query: 361 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 420
KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA
Sbjct: 357 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 416
Query: 421 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 480
PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG
Sbjct: 417 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 476
Query: 481 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR 540
SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR
Sbjct: 477 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR 536
Query: 541 QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV 600
QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV
Sbjct: 537 QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV 596
Query: 601 RQRTLQ---SISPKNFKVKMIMKTSVLLSWE--FPDNYNSP-TPYKIQYNGL 646
RQRTLQ S P++ K + T++L+SW P+ +N Y ++Y L
Sbjct: 597 RQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPL 648
Score = 116 bits (291), Expect = 1e-25
Identities = 159/721 (22%), Positives = 290/721 (40%), Gaps = 103/721 (14%)
Query: 50 ASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRT---------PR 100
A+ +C A+G+P P +TW K F ++ S G RI+ LR+
Sbjct: 152 ATMLCAASGNPDPEITWFKD--------FLPVDPSASNG---RIKQLRSGALQIESSEET 200
Query: 101 DENVYECVAQNSVG-EITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAAS 159
D+ YECVA NS G + A L V ++ P + P + + C A
Sbjct: 201 DQGKYECVATNSAGVRYSSPANLYV----RVRRVAPRFSILPMSHEIMPGGNVNITCVAV 256
Query: 160 GNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSS 219
G+P P + W + + P + G +E ++ D Y CVA +S GV +
Sbjct: 257 GSPMPYVKWMQGAEDLTPE------DDMPVGRNVLELTDVKDSANYTCVAMSSLGV-IEA 309
Query: 220 PANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPY----VKWMQGAED 275
A + V+ L P+ PM E ++ IT + G+P P +++ ++D
Sbjct: 310 VAQITVKSL-------PKAPGTPMVTE-NTATSITITWDS-GNPDPVSYYVIEYKSKSQD 360
Query: 276 --LTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGV---IEAVAQITVKSLP-KAPGTP 329
++D+ R + A++S+G E+V T + P AP
Sbjct: 361 GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420
Query: 330 MVTENTATSITITWDSGNPDPVS----------YYVIEYKSKSQDGP-YQIKEDITTTRY 378
+AT++ + W+ +PV YY +E + + + + + + TT
Sbjct: 421 QARMLSATTMIVQWE----EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT-- 474
Query: 379 SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQW 438
+G L + Y + V A S+G GP S+ + +T + P P N++A S T++ + W
Sbjct: 475 -VGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSW 532
Query: 439 EEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSV 498
P + + I Y + + E +H G D + V L + Y R+ A +
Sbjct: 533 SPPRQES--IIKYELLFR-EGDH--GREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 587
Query: 499 GDGPLSDPIQVKTQQGVPGQP-MNLRAEARSETSITLSWSPPRQES--------IIKYEL 549
G G + ++ +T Q P P +++ + T+I +SW PP E+ ++Y
Sbjct: 588 GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRP 647
Query: 550 LFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT---LQ 606
L E +EV TT ++E L+ T+Y A + G G + V RT +
Sbjct: 648 LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 707
Query: 607 SISPKNFKVKMIMKTSVLLSWEFP---DNYNSPTPYKIQYNGLTLDVDGR---------- 653
S P+ + + + T++ + W P + Y++ Y + + R
Sbjct: 708 SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRME-GAEARGPPRIKDVML 766
Query: 654 --TTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFI 711
+ +IT+L+P T Y+ + G + + G+P+++ + +G +
Sbjct: 767 ADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSL 826
Query: 712 M 712
+
Sbjct: 827 L 827
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 1897 bits (4915), Expect = 0.0
Identities = 985/1291 (76%), Positives = 1046/1291 (81%), Gaps = 61/1291 (4%)
Query: 272 GAEDLTPED--DMPVGRNVLELTDVKDSANY--TCVAMSSLGVIEAVAQITVKS---LPK 324
G+ED P++ +P + L ++ Y T VA + +G + + V++ +P
Sbjct: 662 GSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPS 721
Query: 325 APGTPMVTEN-TATSITITWDSGNPD----PVSYYVIEY---KSKSQDGPYQIKE----- 371
AP + E AT+I + W S P + Y + Y + GP +IK+
Sbjct: 722 APPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLAD 781
Query: 372 ------DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQ 425
D I L P + Y I V+A G G S+ V T +VQ
Sbjct: 782 AQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQ 841
Query: 426 ARMLSATTMIVQWEEPV-EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 484
+++ +WE P + GYR+ + E P+ + +D T + +
Sbjct: 842 --QTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRY--TASGVHK 897
Query: 485 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET-SITLSWSPP---- 539
TY R+ A + G G + + + G P L A + ++ L W PP
Sbjct: 898 GATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAE 957
Query: 540 RQESIIKYELLFREGD-----HGREVGRTFDP--TTSYVVEDLKPNTEYAFRLAARSPQG 592
R +I+KY + RE E+ +P + ++ LKP+T Y ++ A + +G
Sbjct: 958 RNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRG 1017
Query: 593 LGAFTPVVRQRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDV 650
G F+P VR RT +SPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDV
Sbjct: 1018 PGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDV 1077
Query: 651 DGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF 710
DGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF
Sbjct: 1078 DGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF 1137
Query: 711 IMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLR 770
IMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLR
Sbjct: 1138 IMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLR 1197
Query: 771 HSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTF 830
HSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTF
Sbjct: 1198 HSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTF 1257
Query: 831 AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS 890
AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS
Sbjct: 1258 AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS 1317
Query: 891 EPRTKCLLNNADLAPHHPKDPVEMRRINFQTP----------------GMLSHPPIPIAD 934
EPRTKCLLNNADLAPHHPKDPVEMRRINFQTP MLSHPPIPIAD
Sbjct: 1318 EPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPIPIAD 1377
Query: 935 MAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQP 994
MAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQP
Sbjct: 1378 MAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQP 1437
Query: 995 IEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKS 1054
IEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKS
Sbjct: 1438 IEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKS 1497
Query: 1055 RIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPD 1114
RIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPD
Sbjct: 1498 RIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPD 1557
Query: 1115 HGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDV 1174
HGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDV
Sbjct: 1558 HGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDV 1617
Query: 1175 YGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHV 1234
YGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHV
Sbjct: 1618 YGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHV 1677
Query: 1235 TGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYIN 1294
TGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYIN
Sbjct: 1678 TGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYIN 1737
Query: 1295 ASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE 1354
ASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE
Sbjct: 1738 ASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE 1797
Query: 1355 RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFI 1414
RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFI
Sbjct: 1798 RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFI 1857
Query: 1415 DFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRT 1474
DFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRT
Sbjct: 1858 DFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRT 1917
Query: 1475 QRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1505
QRPAMVQTEDEYQFCYQAALEYLGSFDHYAT
Sbjct: 1918 QRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1948
Score = 1227 bits (3174), Expect = 0.0
Identities = 618/661 (93%), Positives = 628/661 (95%), Gaps = 15/661 (2%)
Query: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP
Sbjct: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
Query: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA
Sbjct: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
Query: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS
Sbjct: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
Query: 181 NGRIKQLRS---------GALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREV 231
NGRIKQLRS GALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREV
Sbjct: 181 NGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREV 240
Query: 232 RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL 291
RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL
Sbjct: 241 RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL 300
Query: 292 TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV 351
TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV
Sbjct: 301 TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV 360
Query: 352 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR 411
SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR
Sbjct: 361 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR 420
Query: 412 TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 471
TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV
Sbjct: 421 TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 480
Query: 472 DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 531
DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS
Sbjct: 481 DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 540
Query: 532 ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 591
ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ
Sbjct: 541 ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 600
Query: 592 GLGAFTPVVRQRTLQ---SISPKNFKVKMIMKTSVLLSWE--FPDNYNSP-TPYKIQYNG 645
GLGAFTPVVRQRTLQ S P++ K + T++L+SW P+ +N Y ++Y
Sbjct: 601 GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRP 660
Query: 646 L 646
L
Sbjct: 661 L 661
Score = 123 bits (309), Expect = 1e-27
Identities = 161/729 (22%), Positives = 292/729 (40%), Gaps = 97/729 (13%)
Query: 50 ASFVCQATGDPKPRVTWNK---------KGKKVNSQRFETIEFDESAGAVLRIQPLRTPR 100
A+ +C A+G+P P +TW K ++ R ET E GA L+I+
Sbjct: 152 ATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGA-LQIESSEET- 209
Query: 101 DENVYECVAQNSVG-EITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAAS 159
D+ YECVA NS G + A L V ++ P + P + + C A
Sbjct: 210 DQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAV 269
Query: 160 GNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSS 219
G+P P + W + + P + G +E ++ D Y CVA +S GV +
Sbjct: 270 GSPMPYVKWMQGAEDLTPE------DDMPVGRNVLELTDVKDSANYTCVAMSSLGV-IEA 322
Query: 220 PANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPY----VKWMQGAED 275
A + V+ L P+ PM E ++ IT + G+P P +++ ++D
Sbjct: 323 VAQITVKSL-------PKAPGTPMVTE-NTATSITITWDS-GNPDPVSYYVIEYKSKSQD 373
Query: 276 --LTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGV---IEAVAQITVKSLP-KAPGTP 329
++D+ R + A++S+G E+V T + P AP
Sbjct: 374 GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 433
Query: 330 MVTENTATSITITWDSGNPDPVS----------YYVIEYKSKSQDGP-YQIKEDITTTRY 378
+AT++ + W+ +PV YY +E + + + + + + TT
Sbjct: 434 QARMLSATTMIVQWE----EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT-- 487
Query: 379 SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQW 438
+G L + Y + V A S+G GP S+ + +T + P P N++A S T++ + W
Sbjct: 488 -VGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSW 545
Query: 439 EEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSV 498
P + + I Y + + E +H G D + V L + Y R+ A +
Sbjct: 546 SPPRQES--IIKYELLFR-EGDH--GREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 600
Query: 499 GDGPLSDPIQVKTQQGVPGQP-MNLRAEARSETSITLSWSPPRQES--------IIKYEL 549
G G + ++ +T Q P P +++ + T+I +SW PP E+ ++Y
Sbjct: 601 GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRP 660
Query: 550 LFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT---LQ 606
L E +EV TT ++E L+ T+Y A + G G + V RT +
Sbjct: 661 LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 720
Query: 607 SISPKNFKVKMIMKTSVLLSWEFP---DNYNSPTPYKIQY---------------NGLTL 648
S P+ + + + T++ + W P + Y++ Y + +
Sbjct: 721 SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 780
Query: 649 DVDGRTT-----KKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP 703
D T + +IT+L+P T Y+ + G + + G+P+++
Sbjct: 781 DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 840
Query: 704 KPDADGFIM 712
+ +G ++
Sbjct: 841 QQTPEGSLL 849
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 1541 bits (3990), Expect = 0.0
Identities = 796/1214 (65%), Positives = 938/1214 (77%), Gaps = 42/1214 (3%)
Query: 318 TVKSLPKAPGTPMVTENT-ATSITITWDSGNPDP----VSYYVIEY---KSKSQDGPYQI 369
T + +P P + E +TS+ ++W S P+ + Y + Y ++ G +
Sbjct: 706 TNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPML 765
Query: 370 KEDITTTRYS--IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQAR 427
K+ + I GL P + Y + V+A + G G S+ + T P PR V
Sbjct: 766 KDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLV-IN 823
Query: 428 MLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDET 487
T ++QW PV+ G ++GYR+ + + P+ + +D T + + +
Sbjct: 824 HTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT--DIHKGAS 881
Query: 488 YTVRVLAFTSVGDGP-----LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPP--- 539
Y R+ A VG G +S P +V T G P NL +E + TS+ LSW PP
Sbjct: 882 YVFRLSARNKVGFGEEMVKEISIPEEVPT-----GFPQNLHSEGTTSTSVQLSWQPPVLA 936
Query: 540 -RQESIIKYELLFREGDHGR-EVGRTFDPT-TSYVVEDLKPNTEYAFRLAARSPQGLGAF 596
R I KY LL+R+ + + + P T+ + LKP+T Y ++ A + +G G +
Sbjct: 937 ERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPY 996
Query: 597 TPVVRQRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDG 652
+P V+ RTL + KNF VK +MKTSVLLSWE P+NYNS P+KI Y+ + +VDG
Sbjct: 997 SPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDG 1056
Query: 653 RTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIM 712
R T+KLI +LKP Y+FVLTNRG+S GGLQ VTA TA ++L KP+ K + DG I
Sbjct: 1057 RATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMIT 1116
Query: 713 VYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHS 772
V LP+ + ++ Y+I++VPL+KSRG +F+ P SP++M+L+EL+++ISR +RRS+R+
Sbjct: 1117 VQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR-KRRSIRYG 1174
Query: 773 RQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FA 831
R++E+ +PYIAA F VLP F GD K YGGF N+ L+ G YV FVLAV++ +E +A
Sbjct: 1175 REVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYA 1233
Query: 832 ASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSE 891
SP+SDP + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK K R +S+
Sbjct: 1234 TSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRK----RAESD 1289
Query: 892 PRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLS 951
R + NN ++ HHP DPVE+RR+NFQTPGM SHPPIPI ++A+H ERLKAND+LK S
Sbjct: 1290 SRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFS 1349
Query: 952 QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDG 1011
QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV+L IEGI GSDY+NANY+DG
Sbjct: 1350 QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDG 1409
Query: 1012 YRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYG 1071
YR QNAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G
Sbjct: 1410 YRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHG 1469
Query: 1072 FIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRV 1131
+QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRV
Sbjct: 1470 LVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRV 1529
Query: 1132 KTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQT 1191
KTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQT
Sbjct: 1530 KTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQT 1589
Query: 1192 EDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHT 1251
EDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHT
Sbjct: 1590 EDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHT 1649
Query: 1252 SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQ 1311
SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQ
Sbjct: 1650 SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQ 1709
Query: 1312 GPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN 1371
GPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN
Sbjct: 1710 GPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN 1769
Query: 1372 MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG 1431
MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG
Sbjct: 1770 MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG 1829
Query: 1432 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ 1491
PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+
Sbjct: 1830 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1889
Query: 1492 AALEYLGSFDHYAT 1505
AALEYLGSFDHYAT
Sbjct: 1890 AALEYLGSFDHYAT 1903
Score = 902 bits (2331), Expect = 0.0
Identities = 448/669 (66%), Positives = 535/669 (79%), Gaps = 24/669 (3%)
Query: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
Query: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
Query: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS---------GALQIESSEE 199
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS GALQIE SEE
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
Query: 200 TDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVA 259
+DQGKYECVATNSAG RYS+PANLYVRELREVRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
Query: 260 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 319
VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319
Query: 320 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 379
K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS
Sbjct: 320 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379
Query: 380 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 439
+ GLSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 380 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439
Query: 440 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 499
EP EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+G
Sbjct: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
Query: 500 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 559
DGPLS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559
Query: 560 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ---SISPKNFKVK 616
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+Q S P++
Sbjct: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619
Query: 617 MIMKTSVLLSWEFP--DNYNS-PTPYKIQYNGL---------TLDVDGRTTKKLITHLKP 664
TS+L+SW+ P + N T Y I+Y + L + TTK L+ L+
Sbjct: 620 SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679
Query: 665 HTFYNFVLT 673
T Y +T
Sbjct: 680 WTEYRITVT 688
Score = 133 bits (335), Expect = 1e-30
Identities = 112/403 (27%), Positives = 181/403 (44%), Gaps = 36/403 (8%)
Query: 300 YTCVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITWDSGNPDPVSYYV 355
+ A S G+ + A+I+ +++ P P T ++TSI ++W + + +
Sbjct: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
Query: 356 IEYKSK------SQDGPYQIKE-DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESV 408
EY K D P++I TT+Y + L +EY I V+A +G GP S SV
Sbjct: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702
Query: 409 VTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRVYYT-MEPEHPVGN 465
+ RT E P+ PR V+ +++T++ V W PV + +G IRGY+V+Y ME P G
Sbjct: 703 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 762
Query: 466 WQKHNV--DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLR 523
+V D+ + L + +Y++ V A+T+ GDG S P V T VPG+P +
Sbjct: 763 PMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVI 822
Query: 524 AEARSETSITLSWSPPRQE--SIIKYELLFREGDHGREVGRTF-DPTTSYVVEDLKPNTE 580
+ T++ + W PP + Y L F D F + + D+
Sbjct: 823 NHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGAS 881
Query: 581 YAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKM----IMKTSVLLSWEFP---DNY 633
Y FRL+AR+ G G +V++ ++ P F + TSV LSW+ P +
Sbjct: 882 YVFRLSARNKVGFG--EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERN 939
Query: 634 NSPTPYKIQYNGLTLD-------VDGRTTKKLITHLKPHTFYN 669
T Y + Y + + + T +T LKP T Y+
Sbjct: 940 GIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYD 982
Score = 94.4 bits (233), Expect = 8e-19
Identities = 113/473 (23%), Positives = 188/473 (39%), Gaps = 90/473 (19%)
Query: 228 LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 279
LR PRF+ P+ + GG + C A G P P + W Q E + +
Sbjct: 16 LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75
Query: 280 DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 330
D + L +D A Y CVA +++G I ++TV + P G P
Sbjct: 76 DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135
Query: 331 VTENTATSITITWDSGNPDP-VSYY--------------------------------VIE 357
V E T T+ + SGNPDP ++++ IE
Sbjct: 136 VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIE 195
Query: 358 YKSKSQDGPYQ-IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQA 416
+S G Y+ + + TRYS + ++V + + + PP S+ E
Sbjct: 196 QSEESDQGKYECVATNSAGTRYS-------APANLYVRELREVRRVPPRFSIPPTNHEIM 248
Query: 417 PASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLL 476
P + N+ + + V+W E T E + P+G NV
Sbjct: 249 PGGSV-NITCVAVGSPMPYVKWMLGAED----------LTPEDDMPIG----RNV----- 288
Query: 477 TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSW 536
+ + + YT +A +++G I VK PG P+ + A TSITL+W
Sbjct: 289 LELNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTW 343
Query: 537 SPPRQESIIKYELLFREGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLG 594
E + Y ++ + + E+ + D TT Y V L P ++Y FR+ A + G G
Sbjct: 344 DSGNPEP-VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRG 402
Query: 595 -AFTPVVRQRTLQ--SISPKNFKVKMIMKTSVLLSWEFPDNYNSPTP-YKIQY 643
PV+ Q + Q S +P++ + +M+ T++L+ W+ P+ N Y++ Y
Sbjct: 403 PPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY 455
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 1541 bits (3989), Expect = 0.0
Identities = 798/1223 (65%), Positives = 939/1223 (76%), Gaps = 51/1223 (4%)
Query: 318 TVKSLPKAPGTPMVTENT-ATSITITWDSGNPDP----VSYYVIEY---KSKSQDGPYQI 369
T + +P P + E +TS+ ++W S P+ + Y + Y ++ G +
Sbjct: 706 TNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPML 765
Query: 370 KE-----------DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPA 418
K+ D T I GL P + Y + V+A + G G S+ + T P
Sbjct: 766 KDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 825
Query: 419 SAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT 478
PR V T ++QW PV+ G ++GYR+ + + P+ + +D T
Sbjct: 826 K-PRLV-INHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT 883
Query: 479 VGSLLEDETYTVRVLAFTSVGDGP-----LSDPIQVKTQQGVPGQPMNLRAEARSETSIT 533
+ + +Y R+ A VG G +S P +V T G P NL +E + TS+
Sbjct: 884 --DIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT-----GFPQNLHSEGTTSTSVQ 936
Query: 534 LSWSPP----RQESIIKYELLFREGDHGR-EVGRTFDPT-TSYVVEDLKPNTEYAFRLAA 587
LSW PP R I KY LL+R+ + + + P T+ + LKP+T Y ++ A
Sbjct: 937 LSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRA 996
Query: 588 RSPQGLGAFTPVVRQRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG 645
+ +G G ++P V+ RTL + KNF VK +MKTSVLLSWE P+NYNS P+KI Y+
Sbjct: 997 HTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDD 1056
Query: 646 --LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP 703
+ +VDGR T+KLI +LKP Y+FVLTNRG+S GGLQ VTA TA ++L KP+
Sbjct: 1057 GKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIG 1116
Query: 704 KPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISR 763
K + DG I V LP+ + ++ Y+I++VPL+KSRG +F+ P SP++M+L+EL+++ISR
Sbjct: 1117 KTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR 1175
Query: 764 LQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVL 823
+RRS+R+ R++E+ +PYIAA F VLP F GD K YGGF N+ L+ G YV FVLAV+
Sbjct: 1176 -KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM 1233
Query: 824 QKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK 882
+ +E +A SP+SDP + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK K
Sbjct: 1234 EHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRK 1293
Query: 883 PDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERL 942
R +S+ R + NN ++ HHP DPVE+RR+NFQTPGM SHPPIPI ++A+H ERL
Sbjct: 1294 ----RAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERL 1349
Query: 943 KANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSD 1002
KAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV+L IEGI GSD
Sbjct: 1350 KANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSD 1409
Query: 1003 YINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYW 1062
Y+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYW
Sbjct: 1410 YVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYW 1469
Query: 1063 PNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPT 1122
P+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PT
Sbjct: 1470 PSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPT 1529
Query: 1123 PFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMR 1182
PFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR
Sbjct: 1530 PFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMR 1589
Query: 1183 SQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFK 1242
+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFK
Sbjct: 1590 AQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFK 1649
Query: 1243 RLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1302
RLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR
Sbjct: 1650 RLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1709
Query: 1303 QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1362
QQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYF
Sbjct: 1710 QQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1769
Query: 1363 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1422
VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK
Sbjct: 1770 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1829
Query: 1423 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1482
TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT
Sbjct: 1830 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1889
Query: 1483 EDEYQFCYQAALEYLGSFDHYAT 1505
ED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1890 EDQYQFSYRAALEYLGSFDHYAT 1912
Score = 902 bits (2331), Expect = 0.0
Identities = 448/669 (66%), Positives = 535/669 (79%), Gaps = 24/669 (3%)
Query: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
Query: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
Query: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS---------GALQIESSEE 199
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS GALQIE SEE
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
Query: 200 TDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVA 259
+DQGKYECVATNSAG RYS+PANLYVRELREVRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
Query: 260 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 319
VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319
Query: 320 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 379
K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS
Sbjct: 320 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379
Query: 380 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 439
+ GLSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 380 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439
Query: 440 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 499
EP EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+G
Sbjct: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
Query: 500 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 559
DGPLS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559
Query: 560 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ---SISPKNFKVK 616
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+Q S P++
Sbjct: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619
Query: 617 MIMKTSVLLSWEFP--DNYNS-PTPYKIQYNGL---------TLDVDGRTTKKLITHLKP 664
TS+L+SW+ P + N T Y I+Y + L + TTK L+ L+
Sbjct: 620 SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679
Query: 665 HTFYNFVLT 673
T Y +T
Sbjct: 680 WTEYRITVT 688
Score = 129 bits (325), Expect = 2e-29
Identities = 113/412 (27%), Positives = 182/412 (44%), Gaps = 45/412 (10%)
Query: 300 YTCVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITWDSGNPDPVSYYV 355
+ A S G+ + A+I+ +++ P P T ++TSI ++W + + +
Sbjct: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
Query: 356 IEYKSK------SQDGPYQIKE-DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESV 408
EY K D P++I TT+Y + L +EY I V+A +G GP S SV
Sbjct: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702
Query: 409 VTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRVYYT-MEPEHPVGN 465
+ RT E P+ PR V+ +++T++ V W PV + +G IRGY+V+Y ME P G
Sbjct: 703 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 762
Query: 466 WQKHNV---------DDSLL--TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG 514
+V DD+ + L + +Y++ V A+T+ GDG S P V T
Sbjct: 763 PMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA 822
Query: 515 VPGQPMNLRAEARSETSITLSWSPPRQE--SIIKYELLFREGDHGREVGRTF-DPTTSYV 571
VPG+P + + T++ + W PP + Y L F D F + +
Sbjct: 823 VPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFT 881
Query: 572 VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKM----IMKTSVLLSW 627
D+ Y FRL+AR+ G G +V++ ++ P F + TSV LSW
Sbjct: 882 ATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSW 939
Query: 628 EFP---DNYNSPTPYKIQYNGLTLD-------VDGRTTKKLITHLKPHTFYN 669
+ P + T Y + Y + + + T +T LKP T Y+
Sbjct: 940 QPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYD 991
Score = 94.4 bits (233), Expect = 8e-19
Identities = 113/473 (23%), Positives = 188/473 (39%), Gaps = 90/473 (19%)
Query: 228 LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 279
LR PRF+ P+ + GG + C A G P P + W Q E + +
Sbjct: 16 LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75
Query: 280 DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 330
D + L +D A Y CVA +++G I ++TV + P G P
Sbjct: 76 DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135
Query: 331 VTENTATSITITWDSGNPDP-VSYY--------------------------------VIE 357
V E T T+ + SGNPDP ++++ IE
Sbjct: 136 VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIE 195
Query: 358 YKSKSQDGPYQ-IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQA 416
+S G Y+ + + TRYS + ++V + + + PP S+ E
Sbjct: 196 QSEESDQGKYECVATNSAGTRYS-------APANLYVRELREVRRVPPRFSIPPTNHEIM 248
Query: 417 PASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLL 476
P + N+ + + V+W E T E + P+G NV
Sbjct: 249 PGGSV-NITCVAVGSPMPYVKWMLGAED----------LTPEDDMPIG----RNV----- 288
Query: 477 TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSW 536
+ + + YT +A +++G I VK PG P+ + A TSITL+W
Sbjct: 289 LELNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTW 343
Query: 537 SPPRQESIIKYELLFREGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLG 594
E + Y ++ + + E+ + D TT Y V L P ++Y FR+ A + G G
Sbjct: 344 DSGNPEP-VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRG 402
Query: 595 -AFTPVVRQRTLQ--SISPKNFKVKMIMKTSVLLSWEFPDNYNSPTP-YKIQY 643
PV+ Q + Q S +P++ + +M+ T++L+ W+ P+ N Y++ Y
Sbjct: 403 PPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY 455
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 1541 bits (3989), Expect = 0.0
Identities = 798/1223 (65%), Positives = 939/1223 (76%), Gaps = 51/1223 (4%)
Query: 318 TVKSLPKAPGTPMVTENT-ATSITITWDSGNPDP----VSYYVIEY---KSKSQDGPYQI 369
T + +P P + E +TS+ ++W S P+ + Y + Y ++ G +
Sbjct: 693 TNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPML 752
Query: 370 KE-----------DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPA 418
K+ D T I GL P + Y + V+A + G G S+ + T P
Sbjct: 753 KDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 812
Query: 419 SAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT 478
PR V T ++QW PV+ G ++GYR+ + + P+ + +D T
Sbjct: 813 K-PRLV-INHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT 870
Query: 479 VGSLLEDETYTVRVLAFTSVGDGP-----LSDPIQVKTQQGVPGQPMNLRAEARSETSIT 533
+ + +Y R+ A VG G +S P +V T G P NL +E + TS+
Sbjct: 871 --DIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT-----GFPQNLHSEGTTSTSVQ 923
Query: 534 LSWSPP----RQESIIKYELLFREGDHGR-EVGRTFDPT-TSYVVEDLKPNTEYAFRLAA 587
LSW PP R I KY LL+R+ + + + P T+ + LKP+T Y ++ A
Sbjct: 924 LSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRA 983
Query: 588 RSPQGLGAFTPVVRQRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG 645
+ +G G ++P V+ RTL + KNF VK +MKTSVLLSWE P+NYNS P+KI Y+
Sbjct: 984 HTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDD 1043
Query: 646 --LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP 703
+ +VDGR T+KLI +LKP Y+FVLTNRG+S GGLQ VTA TA ++L KP+
Sbjct: 1044 GKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIG 1103
Query: 704 KPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISR 763
K + DG I V LP+ + ++ Y+I++VPL+KSRG +F+ P SP++M+L+EL+++ISR
Sbjct: 1104 KTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR 1162
Query: 764 LQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVL 823
+RRS+R+ R++E+ +PYIAA F VLP F GD K YGGF N+ L+ G YV FVLAV+
Sbjct: 1163 -KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM 1220
Query: 824 QKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK 882
+ +E +A SP+SDP + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK K
Sbjct: 1221 EHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRK 1280
Query: 883 PDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERL 942
R +S+ R + NN ++ HHP DPVE+RR+NFQTPGM SHPPIPI ++A+H ERL
Sbjct: 1281 ----RAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERL 1336
Query: 943 KANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSD 1002
KAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV+L IEGI GSD
Sbjct: 1337 KANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSD 1396
Query: 1003 YINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYW 1062
Y+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYW
Sbjct: 1397 YVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYW 1456
Query: 1063 PNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPT 1122
P+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PT
Sbjct: 1457 PSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPT 1516
Query: 1123 PFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMR 1182
PFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR
Sbjct: 1517 PFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMR 1576
Query: 1183 SQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFK 1242
+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFK
Sbjct: 1577 AQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFK 1636
Query: 1243 RLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1302
RLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR
Sbjct: 1637 RLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1696
Query: 1303 QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1362
QQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYF
Sbjct: 1697 QQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1756
Query: 1363 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1422
VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK
Sbjct: 1757 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1816
Query: 1423 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1482
TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT
Sbjct: 1817 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1876
Query: 1483 EDEYQFCYQAALEYLGSFDHYAT 1505
ED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1877 EDQYQFSYRAALEYLGSFDHYAT 1899
Score = 897 bits (2317), Expect = 0.0
Identities = 444/660 (67%), Positives = 531/660 (80%), Gaps = 19/660 (2%)
Query: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
Query: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
Query: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECV 208
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRSGALQIE SEE+DQGKYECV
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECV 199
Query: 209 ATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK 268
ATNSAG RYS+PANLYVR VRRV PRFSI P +HEIMPGG+VNITCVAVGSPMPYVK
Sbjct: 200 ATNSAGTRYSAPANLYVR----VRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVK 255
Query: 269 WMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGT 328
WM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITVK+LPK PGT
Sbjct: 256 WMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGT 315
Query: 329 PMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSE 388
P+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS+ GLSP S+
Sbjct: 316 PVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSD 375
Query: 389 YEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLI 448
YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+EP EPNG I
Sbjct: 376 YEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQI 435
Query: 449 RGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQ 508
+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+GDGPLS IQ
Sbjct: 436 QGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQ 495
Query: 509 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 568
V TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E T +P T
Sbjct: 496 VITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGT 555
Query: 569 SYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ---SISPKNFKVKMIMKTSVLL 625
SY ++ LKPN+ Y FRLAARSPQGLGA T + RT+Q S P++ TS+L+
Sbjct: 556 SYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILV 615
Query: 626 SWEFP--DNYNS-PTPYKIQYNGL---------TLDVDGRTTKKLITHLKPHTFYNFVLT 673
SW+ P + N T Y I+Y + L + TTK L+ L+ T Y +T
Sbjct: 616 SWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVT 675
Score = 129 bits (325), Expect = 2e-29
Identities = 113/412 (27%), Positives = 182/412 (44%), Gaps = 45/412 (10%)
Query: 300 YTCVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITWDSGNPDPVSYYV 355
+ A S G+ + A+I+ +++ P P T ++TSI ++W + + +
Sbjct: 570 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 629
Query: 356 IEYKSK------SQDGPYQIKE-DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESV 408
EY K D P++I TT+Y + L +EY I V+A +G GP S SV
Sbjct: 630 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 689
Query: 409 VTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRVYYT-MEPEHPVGN 465
+ RT E P+ PR V+ +++T++ V W PV + +G IRGY+V+Y ME P G
Sbjct: 690 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 749
Query: 466 WQKHNV---------DDSLL--TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG 514
+V DD+ + L + +Y++ V A+T+ GDG S P V T
Sbjct: 750 PMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA 809
Query: 515 VPGQPMNLRAEARSETSITLSWSPPRQE--SIIKYELLFREGDHGREVGRTF-DPTTSYV 571
VPG+P + + T++ + W PP + Y L F D F + +
Sbjct: 810 VPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFT 868
Query: 572 VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKM----IMKTSVLLSW 627
D+ Y FRL+AR+ G G +V++ ++ P F + TSV LSW
Sbjct: 869 ATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSW 926
Query: 628 EFP---DNYNSPTPYKIQYNGLTLD-------VDGRTTKKLITHLKPHTFYN 669
+ P + T Y + Y + + + T +T LKP T Y+
Sbjct: 927 QPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYD 978
Score = 93.6 bits (231), Expect = 1e-18
Identities = 110/453 (24%), Positives = 184/453 (40%), Gaps = 63/453 (13%)
Query: 228 LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 279
LR PRF+ P+ + GG + C A G P P + W Q E + +
Sbjct: 16 LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75
Query: 280 DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 330
D + L +D A Y CVA +++G I ++TV + P G P
Sbjct: 76 DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135
Query: 331 VTENTATSITITWDSGNPDPVSYYVIEYK-----------SKSQDGPYQIK--EDITTTR 377
V E T T+ + SGNPDP + ++ + + G QI+ E+ +
Sbjct: 136 VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGK 195
Query: 378 YS-IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIV 436
Y + S + Y + + + PP S+ E P + N+ + + V
Sbjct: 196 YECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSV-NITCVAVGSPMPYV 254
Query: 437 QWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFT 496
+W E T E + P+G NV + + + YT +A +
Sbjct: 255 KWMLGAED----------LTPEDDMPIG----RNV-----LELNDVRQSANYT--CVAMS 293
Query: 497 SVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDH 556
++G I VK PG P+ + A TSITL+W E + Y ++ + +
Sbjct: 294 TLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTWDSGNPEP-VSYYIIQHKPKN 349
Query: 557 GREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLG-AFTPVVRQRTLQ--SISPK 611
E+ + D TT Y V L P ++Y FR+ A + G G PV+ Q + Q S +P+
Sbjct: 350 SEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPR 409
Query: 612 NFKVKMIMKTSVLLSWEFPDNYNSPTP-YKIQY 643
+ + +M+ T++L+ W+ P+ N Y++ Y
Sbjct: 410 DVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY 442
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 1407 bits (3642), Expect = 0.0
Identities = 736/1149 (64%), Positives = 861/1149 (74%), Gaps = 33/1149 (2%)
Query: 371 EDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLS 430
ED TT I GL+P + Y + V+A + G G S+ + T P + ++
Sbjct: 778 EDYETT---ISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMN 834
Query: 431 ATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTV 490
T ++QW P E G + GYR+ Y E N DD T G L + TY
Sbjct: 835 --TALLQWHPPKELPGELLGYRLQYCRADEARP-NTIDFGKDDQHFTVTG-LHKGTTYIF 890
Query: 491 RVLAFTSVGDGPLSDPIQVKTQQGVP-GQPMNLRAEARSETSITLSWSPP----RQESII 545
R+ A G G + +++T + +P G P NL + ++ L+W PP R II
Sbjct: 891 RLAAKNRAGLGEEFEK-EIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRII 949
Query: 546 KYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTL 605
Y ++FR+ + +E+ + T + + LKP+T Y ++ A + +G G +P ++ RT+
Sbjct: 950 SYTVVFRDINSQQEL-QNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTM 1008
Query: 606 --QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLK 663
+ + KNF+V MKTSVLLSWE PD+Y S P+KI YNG +++VDG + +KLI L+
Sbjct: 1009 PVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQ 1068
Query: 664 PHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVP 723
P+T Y+FVL NRGSS GGLQ V+ TA +LL KP A DG + +P Q P
Sbjct: 1069 PNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSL 1128
Query: 724 VQSYFIVMVPLRKSRGGQFLTPLGS-PEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYI 782
V+ ++IV+VP+ + GG LTP S PE+++L+EL++ I + R RQ E +PY+
Sbjct: 1129 VRWFYIVVVPIDRV-GGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYV 1187
Query: 783 AARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQK--SEPTFAASPFSDPFQ 840
AA+ VLP TF GD+K Y GF NR L P Y FVLA L++ + +A+SP+SD
Sbjct: 1188 AAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIV 1247
Query: 841 LDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK----PDSKRKDSEPRTKC 896
+ Q + E ++WV GPVLAV+ II IVIAILL+K K P SK + S
Sbjct: 1248 VQVTPAQQQEEPE--MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDS 1305
Query: 897 LLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYES 956
LL H DPVEMRR+N+QTPGM HPPIPI D+A++ ERLKAND LK SQEYES
Sbjct: 1306 LLA-------HSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYES 1358
Query: 957 IDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQN 1016
IDPGQQFTWE+SNLEVNKPKNRYANVIAYDHSRVIL I+G+ GSDYINANY+DGYR QN
Sbjct: 1359 IDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQN 1418
Query: 1017 AYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVT 1076
AYIATQGPLPET GDFWRMVWEQR+AT+VMMTRLEEKSR+KCDQYWP RGTET G IQVT
Sbjct: 1419 AYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVT 1478
Query: 1077 LLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNP 1136
LLDT+ELAT+ VRTF+LHK+GSSEKRE+RQFQF AWPDHGVPEYPTP LAFLRRVK CNP
Sbjct: 1479 LLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNP 1538
Query: 1137 PDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYS 1196
DAGP+VVHCSAGVGRTGCFIVIDAMLER+K EKTVD+YGHVT MRSQRNYMVQTEDQY
Sbjct: 1539 LDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYV 1598
Query: 1197 FIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFIS 1256
FIHEALLEA CG+TEVPAR+LYA+IQKL QV PGE VT MELEFK LA+SKAHTSRFIS
Sbjct: 1599 FIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFIS 1658
Query: 1257 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1316
ANLPCNKFKNRLVNIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE
Sbjct: 1659 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1718
Query: 1317 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYI 1376
+TEDFWRMLWE+NSTI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYI
Sbjct: 1719 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYI 1778
Query: 1377 LREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVH 1436
LREFKVTDARDGQSRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VH
Sbjct: 1779 LREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVH 1838
Query: 1437 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 1496
CSAGVGRTGVFITLSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTED+YQ CY+AALEY
Sbjct: 1839 CSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY 1898
Query: 1497 LGSFDHYAT 1505
LGSFDHYAT
Sbjct: 1899 LGSFDHYAT 1907
Score = 838 bits (2165), Expect = 0.0
Identities = 440/715 (61%), Positives = 528/715 (73%), Gaps = 27/715 (3%)
Query: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
MAP PG V L+++ LV G + P FIK P+DQ G+SGGVASFVCQATG+P
Sbjct: 1 MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60
Query: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
KPR+TW KKGKKV+SQRFE IEFD+ AG+VLRIQPLR RDE +YEC A NS+GEI A
Sbjct: 61 KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120
Query: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
KL+VL E+QLP GFP+IDMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVDP+ S
Sbjct: 121 KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180
Query: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSI 240
NGRIKQLRSGALQIESSEE+DQGKYECVATNSAG RYS+PANLYVR VRRVAPRFSI
Sbjct: 181 NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSI 236
Query: 241 LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY 300
P S E+MPGG+VN+TCVAVG+PMPYVKWM GAE+LT ED+MPVGRNVLEL++V SANY
Sbjct: 237 PPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANY 296
Query: 301 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 360
TCVA+SSLG+IEA AQ+TVK+LPK P +VTE TATS+T+TWDSGN +PV+YY I+Y++
Sbjct: 297 TCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRA 356
Query: 361 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 420
+GP+Q + + TTRYSIGGLSP SEY V AVNSIG+GPPSE+V RTGEQAP+S
Sbjct: 357 AGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSP 416
Query: 421 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 480
PR VQARMLSA+TM+VQWE P EPNGL+RGYRVYYT + P W KHN D LLTTVG
Sbjct: 417 PRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVG 476
Query: 481 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR 540
SLL TY++RVLAFT+VGDGP S IQVKTQQGVP QP + +AE S+T I LSW P
Sbjct: 477 SLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPP 536
Query: 541 QESIIKYELLF-REGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV 599
QE II YEL++ D ++ TFDPT+SY +EDLKP+T Y F+LAARS G+G FTP
Sbjct: 537 QERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPT 596
Query: 600 VRQRTLQ---SISPKNFKVKMIMKTSVLLSWEFP--DNYNSP-TPYKIQYNGLTLDVDGR 653
+ RT Q S P+ + T+V +SW P D+ N T Y + Y + + GR
Sbjct: 597 IEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGR 656
Query: 654 TTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNL-LNGKPSVAPKPDA 707
I+ + H+ ++ V GL++ WT + + + V P P++
Sbjct: 657 HVVDGIS--REHSSWDLV---------GLEK----WTEYRVWVRAHTDVGPGPES 696
Score = 138 bits (347), Expect = 5e-32
Identities = 123/431 (28%), Positives = 190/431 (44%), Gaps = 47/431 (10%)
Query: 291 LTDVKDSANYT--CVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITW- 343
L D+K Y A S +GV I ++ P P M +T++ ++W
Sbjct: 569 LEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWV 628
Query: 344 ----DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITT--TRYSIGGLSPNSEYEIWVSAVN 397
DS N Y V +D + + I+ + + + GL +EY +WV A
Sbjct: 629 PPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT 688
Query: 398 SIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRV-Y 454
+G GP S V+ RT E P+ PR V+ L++T + V W+ PV + +G IRGY+V Y
Sbjct: 689 DVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTY 748
Query: 455 YTMEPEHPVG------------NWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 502
+E P G W+ +D TT+ L + TY+V V A+T+ GDG
Sbjct: 749 VRLENGEPRGLPIIQDVMLAEAQWRPEESED-YETTISGLTPETTYSVTVAAYTTKGDGA 807
Query: 503 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQ--ESIIKYELLFREGDHGREV 560
S P V T VPG+P + + T++ L W PP++ ++ Y L + D R
Sbjct: 808 RSKPKIVTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEARPN 866
Query: 561 GRTFDPTTS-YVVEDLKPNTEYAFRLAARSPQGLG-AFTPVVR-QRTLQSISPKNFKVKM 617
F + V L T Y FRLAA++ GLG F +R L S P+N V
Sbjct: 867 TIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTG 926
Query: 618 IMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGR--------TTKKLITHLKPHTFYN 669
+ ++ L+W+ P I Y + D++ + T+ +T LKP T Y+
Sbjct: 927 LTTSTTELAWD-PPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYD 985
Query: 670 FVL---TNRGS 677
+ T++GS
Sbjct: 986 IKVRAWTSKGS 996
Score = 51.6 bits (122), Expect = 6e-06
Identities = 54/210 (25%), Positives = 89/210 (42%), Gaps = 21/210 (10%)
Query: 318 TVKSLPKA-PGTPMVTENTATSITITWD-----SGNPDPVSYYVIEYKSKSQDGPYQIKE 371
T + LP P VT T ++ + WD N +SY V+ SQ +++
Sbjct: 910 TPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQ---ELQN 966
Query: 372 DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSA 431
T TR+++ GL P++ Y+I V A S G GP S S+ +RT A +N +
Sbjct: 967 ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFA-KNFRVAAAMK 1025
Query: 432 TTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVR 491
T++++ WE P Y + P + N Q VD + + + L+ T
Sbjct: 1026 TSVLLSWEVPDS----------YKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSF 1075
Query: 492 VLAFTSVGDGPLSDPIQVKTQQG-VPGQPM 520
VL G L + ++T +P +P+
Sbjct: 1076 VLMNRGSSAGGLQHLVSIRTAPDLLPHKPL 1105
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 1405 bits (3638), Expect = 0.0
Identities = 732/1141 (64%), Positives = 858/1141 (75%), Gaps = 30/1141 (2%)
Query: 379 SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQW 438
+I GL+P + Y + V+A + G G S+ + T P + ++ T ++QW
Sbjct: 774 TISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMN--TALLQW 831
Query: 439 EEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSV 498
P E G + GYR+ Y E N DD T G L + TY R+ A
Sbjct: 832 HPPKELPGELLGYRLQYCRADEARP-NTIDFGKDDQHFTVTG-LHKGTTYIFRLAAKNRA 889
Query: 499 GDGPLSDPIQVKTQQGVP-GQPMNLRAEARSETSITLSWSPP----RQESIIKYELLFRE 553
G G + +++T + +P G P NL + ++ L+W PP R II Y ++FR+
Sbjct: 890 GLGEEFEK-EIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD 948
Query: 554 GDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTL--QSISPK 611
+ +E+ + T + + LKP+T Y ++ A + +G G +P ++ RT+ + + K
Sbjct: 949 INSQQEL-QNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAK 1007
Query: 612 NFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFV 671
NF+V MKTSVLLSWE PD+Y S P+KI YNG +++VDG + +KLI L+P+T Y+FV
Sbjct: 1008 NFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFV 1067
Query: 672 LTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVM 731
L NRGSS GGLQ V+ TA +LL KP A DG + +P Q P V+ ++IV+
Sbjct: 1068 LMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVV 1127
Query: 732 VPLRKSRGGQFLTPLGS-PEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLP 790
VP+ + GG LTP S PE+++L+EL++ I + R RQ E +PY+AA+ VLP
Sbjct: 1128 VPIDRV-GGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLP 1186
Query: 791 PTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQK--SEPTFAASPFSDPFQLDNPDPQP 848
TF GD+K Y GF NR L P Y FVLA L++ + +A+SP+SD + Q
Sbjct: 1187 ETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQ 1246
Query: 849 IVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK----PDSKRKDSEPRTKCLLNNADLA 904
+ E ++WV GPVLAV+ II IVIAILL+K K P SK + S LL
Sbjct: 1247 QEEPE--MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLA----- 1299
Query: 905 PHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFT 964
H DPVEMRR+N+QTPGM HPPIPI D+A++ ERLKAND LK SQEYESIDPGQQFT
Sbjct: 1300 --HSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFT 1357
Query: 965 WEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGP 1024
WE+SNLEVNKPKNRYANVIAYDHSRVIL I+G+ GSDYINANY+DGYR QNAYIATQGP
Sbjct: 1358 WENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGP 1417
Query: 1025 LPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELA 1084
LPET GDFWRMVWEQR+AT+VMMTRLEEKSR+KCDQYWP RGTET G IQVTLLDT+ELA
Sbjct: 1418 LPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELA 1477
Query: 1085 TFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVV 1144
T+ VRTF+LHK+GSSEKRE+RQFQF AWPDHGVPEYPTP LAFLRRVK CNP DAGP+VV
Sbjct: 1478 TYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVV 1537
Query: 1145 HCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE 1204
HCSAGVGRTGCFIVIDAMLER+K EKTVD+YGHVT MRSQRNYMVQTEDQY FIHEALLE
Sbjct: 1538 HCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1597
Query: 1205 AVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKF 1264
A CG+TEVPAR+LYA+IQKL QV PGE VT MELEFK LA+SKAHTSRFISANLPCNKF
Sbjct: 1598 AATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKF 1657
Query: 1265 KNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRM 1324
KNRLVNIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRM
Sbjct: 1658 KNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRM 1717
Query: 1325 LWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD 1384
LWE+NSTI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD
Sbjct: 1718 LWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD 1777
Query: 1385 ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRT 1444
ARDGQSRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRT
Sbjct: 1778 ARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRT 1837
Query: 1445 GVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA 1504
GVFITLSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTED+YQ CY+AALEYLGSFDHYA
Sbjct: 1838 GVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA 1897
Query: 1505 T 1505
T
Sbjct: 1898 T 1898
Score = 838 bits (2165), Expect = 0.0
Identities = 440/715 (61%), Positives = 528/715 (73%), Gaps = 27/715 (3%)
Query: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
MAP PG V L+++ LV G + P FIK P+DQ G+SGGVASFVCQATG+P
Sbjct: 1 MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60
Query: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
KPR+TW KKGKKV+SQRFE IEFD+ AG+VLRIQPLR RDE +YEC A NS+GEI A
Sbjct: 61 KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120
Query: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
KL+VL E+QLP GFP+IDMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVDP+ S
Sbjct: 121 KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180
Query: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSI 240
NGRIKQLRSGALQIESSEE+DQGKYECVATNSAG RYS+PANLYVR VRRVAPRFSI
Sbjct: 181 NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSI 236
Query: 241 LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY 300
P S E+MPGG+VN+TCVAVG+PMPYVKWM GAE+LT ED+MPVGRNVLEL++V SANY
Sbjct: 237 PPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANY 296
Query: 301 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 360
TCVA+SSLG+IEA AQ+TVK+LPK P +VTE TATS+T+TWDSGN +PV+YY I+Y++
Sbjct: 297 TCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRA 356
Query: 361 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 420
+GP+Q + + TTRYSIGGLSP SEY V AVNSIG+GPPSE+V RTGEQAP+S
Sbjct: 357 AGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSP 416
Query: 421 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 480
PR VQARMLSA+TM+VQWE P EPNGL+RGYRVYYT + P W KHN D LLTTVG
Sbjct: 417 PRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVG 476
Query: 481 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR 540
SLL TY++RVLAFT+VGDGP S IQVKTQQGVP QP + +AE S+T I LSW P
Sbjct: 477 SLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPP 536
Query: 541 QESIIKYELLF-REGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV 599
QE II YEL++ D ++ TFDPT+SY +EDLKP+T Y F+LAARS G+G FTP
Sbjct: 537 QERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPT 596
Query: 600 VRQRTLQ---SISPKNFKVKMIMKTSVLLSWEFP--DNYNSP-TPYKIQYNGLTLDVDGR 653
+ RT Q S P+ + T+V +SW P D+ N T Y + Y + + GR
Sbjct: 597 IEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGR 656
Query: 654 TTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNL-LNGKPSVAPKPDA 707
I+ + H+ ++ V GL++ WT + + + V P P++
Sbjct: 657 HVVDGIS--REHSSWDLV---------GLEK----WTEYRVWVRAHTDVGPGPES 696
Score = 137 bits (346), Expect = 6e-32
Identities = 122/421 (28%), Positives = 190/421 (45%), Gaps = 36/421 (8%)
Query: 291 LTDVKDSANYT--CVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITW- 343
L D+K Y A S +GV I ++ P P M +T++ ++W
Sbjct: 569 LEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWV 628
Query: 344 ----DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITT--TRYSIGGLSPNSEYEIWVSAVN 397
DS N Y V +D + + I+ + + + GL +EY +WV A
Sbjct: 629 PPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT 688
Query: 398 SIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRV-Y 454
+G GP S V+ RT E P+ PR V+ L++T + V W+ PV + +G IRGY+V Y
Sbjct: 689 DVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTY 748
Query: 455 YTMEPEHPVG--NWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQ 512
+E P G Q + ++ TT+ L + TY+V V A+T+ GDG S P V T
Sbjct: 749 VRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTT 808
Query: 513 QGVPGQPMNLRAEARSETSITLSWSPPRQ--ESIIKYELLFREGDHGREVGRTFDPTTS- 569
VPG+P + + T++ L W PP++ ++ Y L + D R F
Sbjct: 809 GAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQH 867
Query: 570 YVVEDLKPNTEYAFRLAARSPQGLG-AFTPVVR-QRTLQSISPKNFKVKMIMKTSVLLSW 627
+ V L T Y FRLAA++ GLG F +R L S P+N V + ++ L+W
Sbjct: 868 FTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAW 927
Query: 628 EFPDNYNSPTPYKIQYNGLTLDVDGR--------TTKKLITHLKPHTFYNFVL---TNRG 676
+ P I Y + D++ + T+ +T LKP T Y+ + T++G
Sbjct: 928 D-PPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKG 986
Query: 677 S 677
S
Sbjct: 987 S 987
Score = 51.6 bits (122), Expect = 6e-06
Identities = 54/210 (25%), Positives = 89/210 (42%), Gaps = 21/210 (10%)
Query: 318 TVKSLPKA-PGTPMVTENTATSITITWD-----SGNPDPVSYYVIEYKSKSQDGPYQIKE 371
T + LP P VT T ++ + WD N +SY V+ SQ +++
Sbjct: 901 TPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQ---ELQN 957
Query: 372 DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSA 431
T TR+++ GL P++ Y+I V A S G GP S S+ +RT A +N +
Sbjct: 958 ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFA-KNFRVAAAMK 1016
Query: 432 TTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVR 491
T++++ WE P Y + P + N Q VD + + + L+ T
Sbjct: 1017 TSVLLSWEVPDS----------YKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSF 1066
Query: 492 VLAFTSVGDGPLSDPIQVKTQQG-VPGQPM 520
VL G L + ++T +P +P+
Sbjct: 1067 VLMNRGSSAGGLQHLVSIRTAPDLLPHKPL 1096
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 592 bits (1525), Expect = e-168
Identities = 312/682 (45%), Positives = 426/682 (62%), Gaps = 22/682 (3%)
Query: 829 TFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRK 888
TF S SD D D PI+ ++ + +L +VFII ++ + K K
Sbjct: 134 TFPPSGNSD--SKDRRDETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHS 187
Query: 889 DSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGM-LSHPPIPIADMAEHTERLKANDS 947
+S L+N P+ + R +P +PP+P+ + E R A+D+
Sbjct: 188 NS-----FRLSNGRTEDVEPQSVPLLAR----SPSTNRKYPPLPVDKLEEEINRRMADDN 238
Query: 948 LKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINA 1006
+E+ ++ Q T E ++ E NK KNRY N++ YDHSRV L P+EG+ SDYINA
Sbjct: 239 KLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINA 298
Query: 1007 NYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG 1066
++++GY+ +N +IA QGP ET DFWRM+WEQ +ATIVM+T L+E+ KC QYWP++G
Sbjct: 299 SFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQG 358
Query: 1067 TETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKRE----VRQFQFTAWPDHGVPEYPT 1122
TYG I+V++ D L + VR F + + G R+ + QF FT+WPD GVP P
Sbjct: 359 CWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPI 418
Query: 1123 PFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMR 1182
L FL++VK CNP AG IVVHCSAGVGRTG F+VIDAML+ + E+ VDVYG V+ +R
Sbjct: 419 GMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIR 478
Query: 1183 SQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFK 1242
+QR MVQT+ QY FI++ALLE G+TE+ SL ++QK+ PG G+E EFK
Sbjct: 479 AQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFK 538
Query: 1243 RLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1302
+L + K + + NLP N KNR++ I+PYE RV + RG E +DY+NASFIDGYR
Sbjct: 539 KLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYR 598
Query: 1303 QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1362
Q+ +YIA+QGPL T EDFWRM+WE S +VMLT+L E G+EKC QYWP++ Y
Sbjct: 599 QKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDI 658
Query: 1363 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1422
V+ E Y +R+ VT+ R+ +SR +RQF F WPE G+P G+G I I V K
Sbjct: 659 TVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQK 718
Query: 1423 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1482
++Q G + PI+VHCSAG GRTG F LS VLER++ EG++D+FQTVK LR QRP MVQT
Sbjct: 719 QQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQT 777
Query: 1483 EDEYQFCYQAALEYLGSFDHYA 1504
++Y+FCY+ EY+ +F YA
Sbjct: 778 LEQYEFCYKVVQEYIDAFSDYA 799
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 589 bits (1518), Expect = e-168
Identities = 306/666 (45%), Positives = 420/666 (63%), Gaps = 20/666 (3%)
Query: 845 DPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLA 904
D PI+ ++ + +L +VFII ++ + K K +S L+N
Sbjct: 139 DETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNS-----FRLSNGRTE 189
Query: 905 PHHPKDPVEMRRINFQTPGM-LSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-Q 962
P+ + R +P +PP+P+ + E R A+D+ +E+ ++ Q
Sbjct: 190 DVEPQSVPLLAR----SPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQ 245
Query: 963 FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQ 1022
T E ++ E NK KNRY N++ YDHSRV L P+EG+ SDYINA++++GY+ +N +IA Q
Sbjct: 246 ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQ 305
Query: 1023 GPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIE 1082
GP ET DFWRM+WEQ +ATIVM+T L+E+ KC QYWP++G TYG I+V++ D
Sbjct: 306 GPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTV 365
Query: 1083 LATFCVRTFSLHKNGSSEKRE----VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1138
L + VR F + + G R+ + QF FT+WPD GVP P L FL++VK CNP
Sbjct: 366 LVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQY 425
Query: 1139 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1198
AG IVVHCSAGVGRTG F+VIDAML+ + E+ VDVYG V+ +R+QR MVQT+ QY FI
Sbjct: 426 AGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFI 485
Query: 1199 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISAN 1258
++ALLE G+TE+ SL ++QK+ PG G+E EFK+L + K + + N
Sbjct: 486 YQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGN 545
Query: 1259 LPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETT 1318
LP N KNR++ I+PYE RV + RG E +DY+NASFIDGYRQ+ +YIA+QGPL T
Sbjct: 546 LPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTI 605
Query: 1319 EDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1378
EDFWRM+WE S +VMLT+L E G+EKC QYWP++ Y V+ E Y +R
Sbjct: 606 EDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVR 665
Query: 1379 EFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCS 1438
+ VT+ R+ +SR +RQF F WPE G+P G+G I I V K ++Q G + PI+VHCS
Sbjct: 666 DLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCS 724
Query: 1439 AGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG 1498
AG GRTG F LS VLER++ EG++D+FQTVK LR QRP MVQT ++Y+FCY+ EY+
Sbjct: 725 AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
Query: 1499 SFDHYA 1504
+F YA
Sbjct: 785 AFSDYA 790
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 589 bits (1518), Expect = e-168
Identities = 306/666 (45%), Positives = 420/666 (63%), Gaps = 20/666 (3%)
Query: 845 DPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLA 904
D PI+ ++ + +L +VFII ++ + K K +S L+N
Sbjct: 139 DETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNS-----FRLSNGRTE 189
Query: 905 PHHPKDPVEMRRINFQTPGM-LSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-Q 962
P+ + R +P +PP+P+ + E R A+D+ +E+ ++ Q
Sbjct: 190 DVEPQSVPLLAR----SPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQ 245
Query: 963 FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQ 1022
T E ++ E NK KNRY N++ YDHSRV L P+EG+ SDYINA++++GY+ +N +IA Q
Sbjct: 246 ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQ 305
Query: 1023 GPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIE 1082
GP ET DFWRM+WEQ +ATIVM+T L+E+ KC QYWP++G TYG I+V++ D
Sbjct: 306 GPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTV 365
Query: 1083 LATFCVRTFSLHKNGSSEKRE----VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1138
L + VR F + + G R+ + QF FT+WPD GVP P L FL++VK CNP
Sbjct: 366 LVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQY 425
Query: 1139 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1198
AG IVVHCSAGVGRTG F+VIDAML+ + E+ VDVYG V+ +R+QR MVQT+ QY FI
Sbjct: 426 AGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFI 485
Query: 1199 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISAN 1258
++ALLE G+TE+ SL ++QK+ PG G+E EFK+L + K + + N
Sbjct: 486 YQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGN 545
Query: 1259 LPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETT 1318
LP N KNR++ I+PYE RV + RG E +DY+NASFIDGYRQ+ +YIA+QGPL T
Sbjct: 546 LPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTI 605
Query: 1319 EDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1378
EDFWRM+WE S +VMLT+L E G+EKC QYWP++ Y V+ E Y +R
Sbjct: 606 EDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVR 665
Query: 1379 EFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCS 1438
+ VT+ R+ +SR +RQF F WPE G+P G+G I I V K ++Q G + PI+VHCS
Sbjct: 666 DLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCS 724
Query: 1439 AGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG 1498
AG GRTG F LS VLER++ EG++D+FQTVK LR QRP MVQT ++Y+FCY+ EY+
Sbjct: 725 AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
Query: 1499 SFDHYA 1504
+F YA
Sbjct: 785 AFSDYA 790
>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
precursor [Homo sapiens]
Length = 700
Score = 552 bits (1423), Expect = e-157
Identities = 297/676 (43%), Positives = 416/676 (61%), Gaps = 32/676 (4%)
Query: 844 PDP---QPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN 900
PDP QP+ L W++ P+L ++ ++ + ++ + + S+ +
Sbjct: 39 PDPGASQPL------LAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKM------ 86
Query: 901 ADLAPHHPKDPVEMRRINFQT---PGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESI 957
P+ + E +R+ + G + PIP+ + E A+D + +E+ S+
Sbjct: 87 ----PNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSL 142
Query: 958 DPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQN 1016
G Q T+E +N E N+ KNRY N++ DHSRVIL ++GI SDYINA+Y+DGY+ +N
Sbjct: 143 PSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKN 202
Query: 1017 AYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVT 1076
+IA QGP ET DFWRMVWEQ+SATIVM+T L+E+ KC QYWP++G TYG I+V
Sbjct: 203 KFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVC 262
Query: 1077 LLDTIELATFCVRTFSLHK---NGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT 1133
+ D + L + +R F + +G R V Q FT+WPD GVP P L FL++VKT
Sbjct: 263 VEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKT 322
Query: 1134 CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTED 1193
NP AGPIVVHCSAGVGRTG FIVIDAM+ + E+ VDV+ V+ +R+QR MVQT+
Sbjct: 323 LNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDM 382
Query: 1194 QYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSR 1253
QY+FI++ALLE G+TE+ SL ++Q + G+E EF++L N +
Sbjct: 383 QYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKEN 442
Query: 1254 FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP 1313
+ NLP N K R++ I+PY+ RV L RG E +DYINASFIDGYRQ+ +IATQGP
Sbjct: 443 MRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGP 502
Query: 1314 LAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMP 1373
LA T EDFWRM+WE S +VMLT+++E ++KC+QYWP E S + ++ +
Sbjct: 503 LAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSE 562
Query: 1374 QYILREFKVT-----DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFG 1428
+R+F VT ++ Q R VRQF F WPE G+P G+G ID I V K ++Q G
Sbjct: 563 AISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG 622
Query: 1429 QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQF 1488
+ PI+VHCSAG GRTG FI LS +LER++ EG++D+FQ VK LR QRP MVQT ++Y+F
Sbjct: 623 -NHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEF 681
Query: 1489 CYQAALEYLGSFDHYA 1504
CY+ +++ F YA
Sbjct: 682 CYKVVQDFIDIFSDYA 697
>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
[Homo sapiens]
Length = 642
Score = 549 bits (1414), Expect = e-156
Identities = 283/585 (48%), Positives = 381/585 (65%), Gaps = 10/585 (1%)
Query: 929 PIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDH 987
PIP+ + E A+D + +E+ S+ G Q T+E +N E N+ KNRY N++ DH
Sbjct: 56 PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDH 115
Query: 988 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1047
SRVIL ++GI SDYINA+Y+DGY+ +N +IA QGP ET DFWRMVWEQ+SATIVM+
Sbjct: 116 SRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML 175
Query: 1048 TRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHK---NGSSEKREV 1104
T L+E+ KC QYWP++G TYG I+V + D + L + +R F + +G R V
Sbjct: 176 TNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLV 235
Query: 1105 RQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1164
Q FT+WPD GVP P L FL++VKT NP AGPIVVHCSAGVGRTG FIVIDAM+
Sbjct: 236 SQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMA 295
Query: 1165 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQK 1224
+ E+ VDV+ V+ +R+QR MVQT+ QY+FI++ALLE G+TE+ SL ++Q
Sbjct: 296 MMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQT 355
Query: 1225 LAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1284
+ G+E EF++L N + + NLP N K R++ I+PY+ RV L
Sbjct: 356 MHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMK 415
Query: 1285 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGR 1344
RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +VMLT+++E +
Sbjct: 416 RGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQ 475
Query: 1345 EKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTVRQFQFT 1399
+KC+QYWP E S + ++ + +R+F VT ++ Q R VRQF F
Sbjct: 476 DKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFH 535
Query: 1400 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1459
WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI LS +LER++
Sbjct: 536 GWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNILERVKA 594
Query: 1460 EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA 1504
EG++D+FQ VK LR QRP MVQT ++Y+FCY+ +++ F YA
Sbjct: 595 EGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 521 bits (1341), Expect = e-147
Identities = 379/1141 (33%), Positives = 563/1141 (49%), Gaps = 141/1141 (12%)
Query: 464 GNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLS---DPIQVKTQQGVPGQ-P 519
G+W + + ++ + L D Y +RVL T G+G P+ +T+ P + P
Sbjct: 335 GSWTETHAVNAPTYKLWHLDPDTEYEIRVL-LTRPGEGGTGLPGPPLITRTKCAEPMRTP 393
Query: 520 MNLRAEARSETSITLSWSPPRQE-------SIIKYELLFREGDHGREVGRTFDPTT-SYV 571
L+ I + W ++ FR + + DP +V
Sbjct: 394 KTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHV 453
Query: 572 VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTS----VLLSW 627
V L P T + ++ +P+G + Q T + + P VK + TS + L+W
Sbjct: 454 VNHLPPYTNVSLKMILTNPEGRKESEETIIQ-TDEDV-PGPVPVKSLQGTSFENKIFLNW 511
Query: 628 EFPDNYNSP-TPYKIQYNGL--------------TLDVDGRTTKKLITHLKPHTFYNFVL 672
+ P + N T Y+I Y+ + T+ +T + HL P T Y F +
Sbjct: 512 KEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFI 571
Query: 673 TNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF----------IMVYLPDGQSP- 721
R S++ G N+ S PD +G I V L Q+
Sbjct: 572 --RASTVKGFGPATAINVTTNI-----SAPTLPDYEGVDASLNETATTITVLLRPAQAKG 624
Query: 722 VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPY 781
P+ +Y IV+ L R + G+ E + Q+ + PY
Sbjct: 625 APISAYQIVVEELHPHRTKR---EAGAMECYQVPVTYQNA-------------MSGGAPY 668
Query: 782 IAARFSVLPP-------TFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFA--- 831
A + LPP F GD + Y GF N L P Y ++ A+ + T
Sbjct: 669 YFA--AELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCV 726
Query: 832 -----ASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSK 886
A+ +P + PDP D + + +L + ++ +VI +++ K+K K
Sbjct: 727 RIATKAAATEEPEVI--PDPAKQTDRVVKIAGISAGILVFILLLLVVI-LIVKKSKLAKK 783
Query: 887 RKDSEPRTKCLLNN---------ADLAPHHPKDPVE---MRRINFQ-------------- 920
RKD+ T+ + + AD + H +DP+ M + NF
Sbjct: 784 RKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSR 843
Query: 921 ---TPGMLS------------HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTW 965
P L HP I +AD+ +H +K +DS +EYES GQ +W
Sbjct: 844 LLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASW 903
Query: 966 EHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPL 1025
+ + + N+ KNRY N+IAYDHSRVILQP+E SDYINANY+DGY+ + YIATQGP+
Sbjct: 904 DVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPV 963
Query: 1026 PETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELAT 1085
ET DFWRM+W+++SA IVM+T L E R+KC +YWP+ TE YG +VT ++ LA
Sbjct: 964 HETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAE 1022
Query: 1086 FCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVH 1145
+ VRTF+L + G +E REV+QF FT WPDHGVP + T L+F+RRVK NPP AGPIVVH
Sbjct: 1023 YVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVH 1082
Query: 1146 CSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA 1205
CSAG GRTGC+IVID ML+ + E VD+Y V +RS+R MVQTE+QY FIH+A+LEA
Sbjct: 1083 CSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEA 1142
Query: 1206 VGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLPCNK 1263
CG T +P A + +++ + + ++ EF+ L + A LP N
Sbjct: 1143 CLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNH 1202
Query: 1264 FKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWR 1323
KNR ++++P + L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR
Sbjct: 1203 DKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWR 1261
Query: 1324 MLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREF 1380
++++ T +VML ++ + C QYWP E RY V+ M+ + ++ I R
Sbjct: 1262 LVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRIC 1319
Query: 1381 KVTDARDGQSRTVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCS 1438
+T ++G V+QFQ+ W + VP S F+ I QV K +E+ + +G +HC
Sbjct: 1320 NLTRPQEGY-LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCL 1378
Query: 1439 AGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG 1498
G GR+G+F + IV+E ++ + VVD+F VK LR +P MV+ ++Y+FCY ALEYL
Sbjct: 1379 NGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1438
Query: 1499 S 1499
S
Sbjct: 1439 S 1439
Score = 66.6 bits (161), Expect = 2e-10
Identities = 91/402 (22%), Positives = 150/402 (37%), Gaps = 69/402 (17%)
Query: 246 EIMPGGNVNITCVAVGSPMPYVK-WMQGAEDLTPEDDMPVG--RNV----------LELT 292
E+ G N C+A G + K W+Q +D+PV +N+ L+
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRNG----EDIPVAQTKNINHRRFAASFRLQEV 260
Query: 293 DVKDSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---P 348
D Y CV S G + AQ+ V+ P+ P + T + I ++ +
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Query: 349 DPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSE 406
P+ +EY+ S G + + Y + L P++EYEI V + G G P
Sbjct: 321 GPIILKEVEYRMTS--GSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
Query: 407 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRV--YYTMEPEHPVG 464
++TRT P P+ ++ + A + V WE GY + +T
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
Query: 465 NWQKHN--------VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP 516
++ HN +D V + L T + T+ S+ ++T + VP
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP 490
Query: 517 GQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP------- 566
G P+ E I L+W P + I +YE+ + R+FDP
Sbjct: 491 GPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSS-------IRSFDPAVPVAGP 543
Query: 567 ---------TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV 599
+T +V L P T Y F + A + +G G T +
Sbjct: 544 PQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAI 585
Score = 47.4 bits (111), Expect = 1e-04
Identities = 96/449 (21%), Positives = 167/449 (37%), Gaps = 59/449 (13%)
Query: 146 VERTRTATMLCAASGNPDPEIT-WFKDFLPVD-PSASNGRIKQLRSGA-LQIESSEETDQ 202
V + AT C A+G W + D P A I R A +++ +TDQ
Sbjct: 206 VNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQ 265
Query: 203 GKYECVATNSAGVRYSSPANLYVRELR------EVRRVAPRFSILPMS-HEIMPGGNVNI 255
Y CV + G S+ A L VRE ++ V P + ++ ++ + I+ G + +
Sbjct: 266 DLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIIL 325
Query: 256 TCV-------------AVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTC 302
V AV +P Y W L P+ + + VL LT +
Sbjct: 326 KEVEYRMTSGSWTETHAVNAPT-YKLW-----HLDPDTEYEI--RVL-LTRPGEGG---- 372
Query: 303 VAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIE----- 357
+ L + + + P T + E A I + W+S + +
Sbjct: 373 ---TGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICY 429
Query: 358 --YKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQ 415
++ ++ + D ++ + L P + + + N G+ SE + +T E
Sbjct: 430 HYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDED 488
Query: 416 APASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYY----TMEPEHPVGNWQK--H 469
P P + + W+EP++PNG+I Y + Y + +P PV +
Sbjct: 489 VPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVS 548
Query: 470 NVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA--- 526
N+ +S L TY + A T G GP + I V T P P +A
Sbjct: 549 NLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP-ATAINVTTNISAPTLPDYEGVDASLN 607
Query: 527 RSETSITLSWSPPRQES--IIKYELLFRE 553
+ T+IT+ P + + I Y+++ E
Sbjct: 608 ETATTITVLLRPAQAKGAPISAYQIVVEE 636
Score = 32.3 bits (72), Expect = 3.5
Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 30 EEPPRFIKEPKDQIGVSGGVASFVCQATG-DPKPRVTW--NKKGKKVNSQRFETIEFDES 86
++ P F++ ++ +G A+F C ATG D W + G+ + + + I
Sbjct: 193 DKSPHFLRLGDVEVN-AGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRF 251
Query: 87 AGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPN-IDMGPQLKV 145
A A R+Q + T D+++Y CV Q+ G + ++RE P P + +GP +
Sbjct: 252 A-ASFRLQEV-TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLL 309
Query: 146 VE 147
++
Sbjct: 310 IQ 311
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 514 bits (1324), Expect = e-145
Identities = 379/1147 (33%), Positives = 563/1147 (49%), Gaps = 147/1147 (12%)
Query: 464 GNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLS---DPIQVKTQQGVPGQ-P 519
G+W + + ++ + L D Y +RVL T G+G P+ +T+ P + P
Sbjct: 335 GSWTETHAVNAPTYKLWHLDPDTEYEIRVL-LTRPGEGGTGLPGPPLITRTKCAEPMRTP 393
Query: 520 MNLRAEARSETSITLSWSPPRQE-------SIIKYELLFREGDHGREVGRTFDPTT-SYV 571
L+ I + W ++ FR + + DP +V
Sbjct: 394 KTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHV 453
Query: 572 VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTS----VLLSW 627
V L P T + ++ +P+G + Q T + + P VK + TS + L+W
Sbjct: 454 VNHLPPYTNVSLKMILTNPEGRKESEETIIQ-TDEDV-PGPVPVKSLQGTSFENKIFLNW 511
Query: 628 EFPDNYNSP-TPYKIQYNGL--------------TLDVDGRTTKKLITHLKPHTFYNFVL 672
+ P + N T Y+I Y+ + T+ +T + HL P T Y F +
Sbjct: 512 KEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFI 571
Query: 673 TNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF----------IMVYLPDGQSP- 721
R S++ G N+ S PD +G I V L Q+
Sbjct: 572 --RASTVKGFGPATAINVTTNI-----SAPTLPDYEGVDASLNETATTITVLLRPAQAKG 624
Query: 722 VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPY 781
P+ +Y IV+ L R + G+ E + Q+ + PY
Sbjct: 625 APISAYQIVVEELHPHRTKR---EAGAMECYQVPVTYQNA-------------MSGGAPY 668
Query: 782 IAARFSVLPP-------TFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFA--- 831
A + LPP F GD + Y GF N L P Y ++ A+ + T
Sbjct: 669 YFA--AELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCV 726
Query: 832 -----ASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSK 886
A+ +P + PDP D + + +L + ++ +VI +++ K+K K
Sbjct: 727 RIATKAAATEEPEVI--PDPAKQTDRVVKIAGISAGILVFILLLLVVI-LIVKKSKLAKK 783
Query: 887 RKDSEPRTKCLLNN---------ADLAPHHPKDPVE---MRRINFQ-------------- 920
RKD+ T+ + + AD + H +DP+ M + NF
Sbjct: 784 RKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSR 843
Query: 921 ---TPGMLS------------HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTW 965
P L HP I +AD+ +H +K +DS +EYES GQ +W
Sbjct: 844 LLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASW 903
Query: 966 EHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVD------GYRCQNAYI 1019
+ + + N+ KNRY N+IAYDHSRVILQP+E SDYINANY+D GY+ + YI
Sbjct: 904 DVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYI 963
Query: 1020 ATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLD 1079
ATQGP+ ET DFWRM+W+++SA IVM+T L E R+KC +YWP+ TE YG +VT ++
Sbjct: 964 ATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVE 1022
Query: 1080 TIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDA 1139
LA + VRTF+L + G +E REV+QF FT WPDHGVP + T L+F+RRVK NPP A
Sbjct: 1023 MEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSA 1082
Query: 1140 GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIH 1199
GPIVVHCSAG GRTGC+IVID ML+ + E VD+Y V +RS+R MVQTE+QY FIH
Sbjct: 1083 GPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIH 1142
Query: 1200 EALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFISA 1257
+A+LEA CG T +P A + +++ + + ++ EF+ L + A
Sbjct: 1143 DAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIA 1202
Query: 1258 NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAET 1317
LP N KNR ++++P + L I G E S+YINA+ +D YRQ A+I TQ PL T
Sbjct: 1203 CLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNT 1261
Query: 1318 TEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQ 1374
+DFWR++++ T +VML ++ + C QYWP E RY V+ M+ + ++
Sbjct: 1262 VKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVIN 1319
Query: 1375 YILREFKVTDARDGQSRTVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGP 1432
I R +T ++G V+QFQ+ W + VP S F+ I QV K +E+ + +G
Sbjct: 1320 RIFRICNLTRPQEGY-LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGR 1378
Query: 1433 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQA 1492
+HC G GR+G+F + IV+E ++ + VVD+F VK LR +P MV+ ++Y+FCY
Sbjct: 1379 TIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDV 1438
Query: 1493 ALEYLGS 1499
ALEYL S
Sbjct: 1439 ALEYLES 1445
Score = 66.6 bits (161), Expect = 2e-10
Identities = 91/402 (22%), Positives = 150/402 (37%), Gaps = 69/402 (17%)
Query: 246 EIMPGGNVNITCVAVGSPMPYVK-WMQGAEDLTPEDDMPVG--RNV----------LELT 292
E+ G N C+A G + K W+Q +D+PV +N+ L+
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRNG----EDIPVAQTKNINHRRFAASFRLQEV 260
Query: 293 DVKDSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---P 348
D Y CV S G + AQ+ V+ P+ P + T + I ++ +
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Query: 349 DPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSE 406
P+ +EY+ S G + + Y + L P++EYEI V + G G P
Sbjct: 321 GPIILKEVEYRMTS--GSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
Query: 407 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRV--YYTMEPEHPVG 464
++TRT P P+ ++ + A + V WE GY + +T
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
Query: 465 NWQKHN--------VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP 516
++ HN +D V + L T + T+ S+ ++T + VP
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP 490
Query: 517 GQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP------- 566
G P+ E I L+W P + I +YE+ + R+FDP
Sbjct: 491 GPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSS-------IRSFDPAVPVAGP 543
Query: 567 ---------TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV 599
+T +V L P T Y F + A + +G G T +
Sbjct: 544 PQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAI 585
Score = 47.4 bits (111), Expect = 1e-04
Identities = 96/449 (21%), Positives = 167/449 (37%), Gaps = 59/449 (13%)
Query: 146 VERTRTATMLCAASGNPDPEIT-WFKDFLPVD-PSASNGRIKQLRSGA-LQIESSEETDQ 202
V + AT C A+G W + D P A I R A +++ +TDQ
Sbjct: 206 VNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQ 265
Query: 203 GKYECVATNSAGVRYSSPANLYVRELR------EVRRVAPRFSILPMS-HEIMPGGNVNI 255
Y CV + G S+ A L VRE ++ V P + ++ ++ + I+ G + +
Sbjct: 266 DLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIIL 325
Query: 256 TCV-------------AVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTC 302
V AV +P Y W L P+ + + VL LT +
Sbjct: 326 KEVEYRMTSGSWTETHAVNAPT-YKLW-----HLDPDTEYEI--RVL-LTRPGEGG---- 372
Query: 303 VAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIE----- 357
+ L + + + P T + E A I + W+S + +
Sbjct: 373 ---TGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICY 429
Query: 358 --YKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQ 415
++ ++ + D ++ + L P + + + N G+ SE + +T E
Sbjct: 430 HYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDED 488
Query: 416 APASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYY----TMEPEHPVGNWQK--H 469
P P + + W+EP++PNG+I Y + Y + +P PV +
Sbjct: 489 VPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVS 548
Query: 470 NVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA--- 526
N+ +S L TY + A T G GP + I V T P P +A
Sbjct: 549 NLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP-ATAINVTTNISAPTLPDYEGVDASLN 607
Query: 527 RSETSITLSWSPPRQES--IIKYELLFRE 553
+ T+IT+ P + + I Y+++ E
Sbjct: 608 ETATTITVLLRPAQAKGAPISAYQIVVEE 636
Score = 32.3 bits (72), Expect = 3.5
Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 30 EEPPRFIKEPKDQIGVSGGVASFVCQATG-DPKPRVTW--NKKGKKVNSQRFETIEFDES 86
++ P F++ ++ +G A+F C ATG D W + G+ + + + I
Sbjct: 193 DKSPHFLRLGDVEVN-AGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRF 251
Query: 87 AGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPN-IDMGPQLKV 145
A A R+Q + T D+++Y CV Q+ G + ++RE P P + +GP +
Sbjct: 252 A-ASFRLQEV-TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLL 309
Query: 146 VE 147
++
Sbjct: 310 IQ 311
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 506 bits (1304), Expect = e-143
Identities = 372/1208 (30%), Positives = 571/1208 (47%), Gaps = 155/1208 (12%)
Query: 407 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNW 466
S V+ E P + L A W +P + + G + +E G W
Sbjct: 275 SGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTW 334
Query: 467 QKHNVDDSLLTTVGSLLEDETYTVRVLAFT--SVGDGPLSDPIQVKTQQGVPGQ-PMNLR 523
+ ++ DS + L D Y +RVL G GP P+ +T+ P P N+
Sbjct: 335 AETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVE 394
Query: 524 AEARSETSITLSWSP--------PRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDL 575
+TL W P ++Y+ +F + + E ++ Y + L
Sbjct: 395 IVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQY--EAEEVIQTSSHYTLRGL 452
Query: 576 KPNTEYAFRLAARSPQGLGAFTPVVRQRT--------LQSISPKNFKVKMIMKTSVLLSW 627
+P RL +P+G +V Q L+SI F+ K + + W
Sbjct: 453 RPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEK------IYIQW 506
Query: 628 EFPDNYNSP-TPYKIQYNGL-TLDVDG-------------RTTKKLITHLKPHTFYNFVL 672
+ P+ N T Y+I Y + +LD T L L P T Y+F +
Sbjct: 507 KPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTI 566
Query: 673 TNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQS---PVP 723
+ S+ G VT A + PS+ P + D I V L QS PV
Sbjct: 567 --KASTAKGFGPPVTTRIATKI--SAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVS 622
Query: 724 VQSYFIVMVPLRKSRGGQ-----FLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVP 778
V + L+KSR F P+ L+ L + L+ +L V
Sbjct: 623 VYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANL------PVT 676
Query: 779 RPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFA-----AS 833
+P+ GD K Y G+ N L P Y ++ A+ + + T A+
Sbjct: 677 QPFTV------------GDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLAT 724
Query: 834 PFSDPFQLDNPDPQPIVDGEEGLIWVI-GPVLAVVFIICIVIAILLYKN--------KPD 884
+ + +P+ VD + VI G ++ ++ ++ +++ I +N K
Sbjct: 725 KGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLA 784
Query: 885 SKRKDSE---------------PRTKCLLNNADLA------------------------- 904
K+K+++ P TK + D
Sbjct: 785 KKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLT 844
Query: 905 ----PHHPKDPVEMR--RINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID 958
P+ DPVEM R FQ P I +AD+ +H ++K +EYE++
Sbjct: 845 IQTHPYRTCDPVEMSYPRDQFQ-------PAIRVADLLQHITQMKRGQGYGFKEEYEALP 897
Query: 959 PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAY 1018
GQ +W+ + + N+ KNRY N+I+YDHSRV L ++G SDYINANY+DGY Y
Sbjct: 898 EGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHY 957
Query: 1019 IATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL 1078
IATQGP+ ET DFWRM+W++ SA+IVM+T L E R+KC +YWP+ TE YG I+VTL+
Sbjct: 958 IATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLI 1016
Query: 1079 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1138
+T LA + +RTF++ K G E RE+R F FT+WPDHGVP Y T L F+R+VK NPP+
Sbjct: 1017 ETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPE 1076
Query: 1139 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1198
AGPIVVHCSAG GRTGCFI ID ML+ + E VD++ V +R+QR +VQTE+QY F+
Sbjct: 1077 AGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFV 1136
Query: 1199 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFIS 1256
H+A+LEA CGNT +P + +++++P + + ++ EF+ L +
Sbjct: 1137 HDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSI 1196
Query: 1257 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1316
LP N KNR ++++P + L + G E S+YINA+ +D ++Q A++ TQ PL
Sbjct: 1197 GLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPN 1255
Query: 1317 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYI 1376
T DFWR++++ N + VVML ++ + C QYWP + S Y V+ ++ I
Sbjct: 1256 TVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDII 1313
Query: 1377 LREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF-GQDGP 1432
R F++ + Q R V+ Q+ WP + P S + + ++ K +EQ+ G++G
Sbjct: 1314 HRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGR 1373
Query: 1433 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQA 1492
VHC G GR+G F + V E ++ + ++D+F VK LR + MV+T ++Y+F Y+
Sbjct: 1374 TVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEV 1433
Query: 1493 ALEYLGSF 1500
ALEYL SF
Sbjct: 1434 ALEYLSSF 1441
Score = 85.9 bits (211), Expect = 3e-16
Identities = 109/420 (25%), Positives = 174/420 (41%), Gaps = 49/420 (11%)
Query: 225 VRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK-WMQ---GAEDLTPED 280
VR L R AP F L + E+ G N C+A G + K W+Q G +
Sbjct: 182 VRVLAHPCRKAPHFLRL-QNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT 240
Query: 281 DMPVGRNVLELTDVKDSAN-----YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTEN 334
+ R V D+A Y CV S G + A++ VK P P E
Sbjct: 241 RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---EL 297
Query: 335 TATSITITWDSGNPD------PVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSE 388
A T W N + P+ +EY++ + G + + + Y + L P+ E
Sbjct: 298 LAVGATYLWIKPNANSIIGDGPIILKEVEYRTTT--GTWAETHIVDSPNYKLWHLDPDVE 355
Query: 389 YEIWV--SAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNG 446
YEI V + G GPP + TRT P P+NV+ + A + +QW EP G
Sbjct: 356 YEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFG 411
Query: 447 --LIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLED--ETYTVRVLAFTSVGDGP 502
+ R + T++ ++ V N Q++ ++ + T+ L T+R+ S +G
Sbjct: 412 YAVTRCHSYNLTVQYQY-VFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGR 470
Query: 503 L-SDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFR------ 552
+ S+ + V+T++ VPG P+ E I + W PP + + I YE+ ++
Sbjct: 471 MESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLD 530
Query: 553 -EGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSIS 609
D + G+ F T ++ L P T Y+F + A + +G G P V R IS
Sbjct: 531 PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFG---PPVTTRIATKIS 587
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 498 bits (1283), Expect = e-140
Identities = 276/609 (45%), Positives = 373/609 (61%), Gaps = 16/609 (2%)
Query: 899 NNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID 958
+ + L H E + +QT G L HP I +AD+ +H ++K + +EYES
Sbjct: 851 DTSSLVQSHTYKKREPADVPYQT-GQL-HPAIRVADLLQHITQMKCAEGYGFKEEYESFF 908
Query: 959 PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAY 1018
GQ W+ + + N+ KNRY N+IAYDHSRV LQ IEG SDYIN NY+DGY N Y
Sbjct: 909 EGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHY 968
Query: 1019 IATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL 1078
IATQGP+ ET DFWRMVW + +A+I+M+T L E R+KC +YWP+ TE Y I+VTL+
Sbjct: 969 IATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLI 1027
Query: 1079 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1138
+T LA + +RTF++ K G E RE+RQF FT WPDHGVP + T L F+R+VK+ +PP
Sbjct: 1028 ETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPS 1087
Query: 1139 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1198
AGP+VVHCSAG GRTGCFIVID ML+ + E VD+Y V +RS+R MVQTE+QY FI
Sbjct: 1088 AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFI 1147
Query: 1199 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFIS-- 1256
H+A+LEA CG+T VPA + + + +++P + + ++ EF+ L N T R
Sbjct: 1148 HDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTL-NMVTPTLRVEDCS 1206
Query: 1257 -ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1315
A LP N KNR ++I+P + L I G E S+YINA+ +D Y+Q A+I TQ PL
Sbjct: 1207 IALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLP 1265
Query: 1316 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP---AERSARYQYFVVDPMAEYNM 1372
T +DFWR++ + + T VVML + + C QYWP R Q V E ++
Sbjct: 1266 NTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDI 1323
Query: 1373 PQYILREFKVTDARDGQSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQD 1430
I R + +DG R V+QFQF WP + P S F+ I QV K +E++ G +
Sbjct: 1324 ISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGE 1382
Query: 1431 GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1490
G VHC G GR+G F +SIV E +R++ VD+F VK LR +P MV D+Y+FCY
Sbjct: 1383 GRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCY 1442
Query: 1491 QAALEYLGS 1499
+ ALEYL S
Sbjct: 1443 EVALEYLNS 1451
Score = 133 bits (334), Expect = 1e-30
Identities = 83/243 (34%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 973 NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDF 1032
N KNR +++ D L I+G S+YINA +D Y+ +A+I TQ PLP T DF
Sbjct: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271
Query: 1033 WRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFS 1092
WR+V + ++VM+ ++ C QYWP G +G IQV + R F
Sbjct: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329
Query: 1093 LHKNGSSEK--REVRQFQFTAWPDH-GVPEYPTPFLAFLRRVKTCNPP---DAGPIVVHC 1146
++ + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1330 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1389
Query: 1147 SAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1206
G GR+G F I + E ++ ++TVDV+ V +R+ + MV DQY F +E LE +
Sbjct: 1390 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1449
Query: 1207 GCG 1209
G
Sbjct: 1450 NSG 1452
Score = 77.0 bits (188), Expect = 1e-13
Identities = 97/400 (24%), Positives = 167/400 (41%), Gaps = 43/400 (10%)
Query: 246 EIMPGGNVNITCVAVGSPMPYVK-WMQGAE---------DLTPEDDMPVGRNVLELTDVK 295
E+ G C A+G + + W+QG + +T NV+ T +
Sbjct: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK-R 253
Query: 296 DSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPD---PV 351
D+ Y C+ + GV I A++ VK P P + AT + I ++ + + P+
Sbjct: 254 DAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPI 313
Query: 352 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVV 409
+EY + S G + ++ + +T Y IG L P++EYEI V + G G P ++
Sbjct: 314 VAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALR 371
Query: 410 TRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKH 469
TRT P PR ++ + + + ++W EP N + R + T+ + VG ++
Sbjct: 372 TRTKCADPMRGPRKLEVVEVKSRQITIRW-EPFGYN-VTRCHSYNLTVHYCYQVGGQEQV 429
Query: 470 NVDDSLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMN 521
+ S T T+ +L +V+++ G S + V+T + +PG P
Sbjct: 430 REEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTE 488
Query: 522 LRAEARSETSITLSWSPPRQE--SIIKYELLFR-------EGDHGREVGRT--FDPTTSY 570
+ E I L W P Q I YE+ ++ E D + GR T +
Sbjct: 489 SIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHF 548
Query: 571 VVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISP 610
+ L P T Y+F + A + +G G P Q T + +P
Sbjct: 549 LFFGLYPGTTYSFTIRASTAKGFG--PPATNQFTTKISAP 586
Score = 55.5 bits (132), Expect = 4e-07
Identities = 111/482 (23%), Positives = 174/482 (36%), Gaps = 75/482 (15%)
Query: 464 GNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDP---IQVKTQQGVPGQ-P 519
G+W DS +G L D Y + VL T G+G P ++ +T+ P + P
Sbjct: 325 GSWNDRQPVDSTSYKIGHLDPDTEYEISVL-LTRPGEGGTGSPGPALRTRTKCADPMRGP 383
Query: 520 MNLRAEARSETSITLSWSP-----PRQESI-IKYELLFREGDHGREVGR------TFDPT 567
L IT+ W P R S + ++ G G+E R T +
Sbjct: 384 RKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVG--GQEQVREEVSWDTENSH 441
Query: 568 TSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQ--RTLQSISPKNFKVKMIMKTSVLL 625
+ + +L P T + +L +P+G ++ Q L P + + L
Sbjct: 442 PQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFL 501
Query: 626 SWEFP-DNYNSPTPYKIQYNGLTL---DVD-----------GRTTKKLITHLKPHTFYNF 670
W P Y T Y+I Y ++ ++D G T L L P T Y+F
Sbjct: 502 QWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSF 561
Query: 671 VLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQSP-VP 723
+ R S+ G T F PS+ P D + V L S P
Sbjct: 562 TI--RASTAKGFGPPAT--NQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAP 617
Query: 724 VQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIA 783
V Y IV+ R R + + ++ + Q SL +S+ Y A
Sbjct: 618 VSVYQIVVEEERPRR---------TKKTTEILKCYPVPIHFQNASLLNSQY------YFA 662
Query: 784 ARFSV----LPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT------FAAS 833
A F F GD K Y G+ N L P Y ++ A + + T A
Sbjct: 663 AEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATK 722
Query: 834 PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR 893
+ P + P+P+ D + VI +L V II + + +++ K K KRK++
Sbjct: 723 GAATPKPV--PEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKETMSS 779
Query: 894 TK 895
T+
Sbjct: 780 TR 781
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 498 bits (1283), Expect = e-140
Identities = 276/609 (45%), Positives = 373/609 (61%), Gaps = 16/609 (2%)
Query: 899 NNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID 958
+ + L H E + +QT G L HP I +AD+ +H ++K + +EYES
Sbjct: 864 DTSSLVQSHTYKKREPADVPYQT-GQL-HPAIRVADLLQHITQMKCAEGYGFKEEYESFF 921
Query: 959 PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAY 1018
GQ W+ + + N+ KNRY N+IAYDHSRV LQ IEG SDYIN NY+DGY N Y
Sbjct: 922 EGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHY 981
Query: 1019 IATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL 1078
IATQGP+ ET DFWRMVW + +A+I+M+T L E R+KC +YWP+ TE Y I+VTL+
Sbjct: 982 IATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLI 1040
Query: 1079 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1138
+T LA + +RTF++ K G E RE+RQF FT WPDHGVP + T L F+R+VK+ +PP
Sbjct: 1041 ETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPS 1100
Query: 1139 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1198
AGP+VVHCSAG GRTGCFIVID ML+ + E VD+Y V +RS+R MVQTE+QY FI
Sbjct: 1101 AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFI 1160
Query: 1199 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFIS-- 1256
H+A+LEA CG+T VPA + + + +++P + + ++ EF+ L N T R
Sbjct: 1161 HDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTL-NMVTPTLRVEDCS 1219
Query: 1257 -ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1315
A LP N KNR ++I+P + L I G E S+YINA+ +D Y+Q A+I TQ PL
Sbjct: 1220 IALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLP 1278
Query: 1316 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP---AERSARYQYFVVDPMAEYNM 1372
T +DFWR++ + + T VVML + + C QYWP R Q V E ++
Sbjct: 1279 NTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDI 1336
Query: 1373 PQYILREFKVTDARDGQSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQD 1430
I R + +DG R V+QFQF WP + P S F+ I QV K +E++ G +
Sbjct: 1337 ISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGE 1395
Query: 1431 GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1490
G VHC G GR+G F +SIV E +R++ VD+F VK LR +P MV D+Y+FCY
Sbjct: 1396 GRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCY 1455
Query: 1491 QAALEYLGS 1499
+ ALEYL S
Sbjct: 1456 EVALEYLNS 1464
Score = 133 bits (334), Expect = 1e-30
Identities = 83/243 (34%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 973 NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDF 1032
N KNR +++ D L I+G S+YINA +D Y+ +A+I TQ PLP T DF
Sbjct: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284
Query: 1033 WRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFS 1092
WR+V + ++VM+ ++ C QYWP G +G IQV + R F
Sbjct: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342
Query: 1093 LHKNGSSEK--REVRQFQFTAWPDH-GVPEYPTPFLAFLRRVKTCNPP---DAGPIVVHC 1146
++ + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1343 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1402
Query: 1147 SAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1206
G GR+G F I + E ++ ++TVDV+ V +R+ + MV DQY F +E LE +
Sbjct: 1403 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1462
Query: 1207 GCG 1209
G
Sbjct: 1463 NSG 1465
Score = 77.0 bits (188), Expect = 1e-13
Identities = 97/400 (24%), Positives = 167/400 (41%), Gaps = 43/400 (10%)
Query: 246 EIMPGGNVNITCVAVGSPMPYVK-WMQGAE---------DLTPEDDMPVGRNVLELTDVK 295
E+ G C A+G + + W+QG + +T NV+ T +
Sbjct: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK-R 253
Query: 296 DSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPD---PV 351
D+ Y C+ + GV I A++ VK P P + AT + I ++ + + P+
Sbjct: 254 DAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPI 313
Query: 352 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVV 409
+EY + S G + ++ + +T Y IG L P++EYEI V + G G P ++
Sbjct: 314 VAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALR 371
Query: 410 TRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKH 469
TRT P PR ++ + + + ++W EP N + R + T+ + VG ++
Sbjct: 372 TRTKCADPMRGPRKLEVVEVKSRQITIRW-EPFGYN-VTRCHSYNLTVHYCYQVGGQEQV 429
Query: 470 NVDDSLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMN 521
+ S T T+ +L +V+++ G S + V+T + +PG P
Sbjct: 430 REEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTE 488
Query: 522 LRAEARSETSITLSWSPPRQE--SIIKYELLFR-------EGDHGREVGRT--FDPTTSY 570
+ E I L W P Q I YE+ ++ E D + GR T +
Sbjct: 489 SIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHF 548
Query: 571 VVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISP 610
+ L P T Y+F + A + +G G P Q T + +P
Sbjct: 549 LFFGLYPGTTYSFTIRASTAKGFG--PPATNQFTTKISAP 586
Score = 55.5 bits (132), Expect = 4e-07
Identities = 111/482 (23%), Positives = 174/482 (36%), Gaps = 75/482 (15%)
Query: 464 GNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDP---IQVKTQQGVPGQ-P 519
G+W DS +G L D Y + VL T G+G P ++ +T+ P + P
Sbjct: 325 GSWNDRQPVDSTSYKIGHLDPDTEYEISVL-LTRPGEGGTGSPGPALRTRTKCADPMRGP 383
Query: 520 MNLRAEARSETSITLSWSP-----PRQESI-IKYELLFREGDHGREVGR------TFDPT 567
L IT+ W P R S + ++ G G+E R T +
Sbjct: 384 RKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVG--GQEQVREEVSWDTENSH 441
Query: 568 TSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQ--RTLQSISPKNFKVKMIMKTSVLL 625
+ + +L P T + +L +P+G ++ Q L P + + L
Sbjct: 442 PQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFL 501
Query: 626 SWEFP-DNYNSPTPYKIQYNGLTL---DVD-----------GRTTKKLITHLKPHTFYNF 670
W P Y T Y+I Y ++ ++D G T L L P T Y+F
Sbjct: 502 QWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSF 561
Query: 671 VLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQSP-VP 723
+ R S+ G T F PS+ P D + V L S P
Sbjct: 562 TI--RASTAKGFGPPAT--NQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAP 617
Query: 724 VQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIA 783
V Y IV+ R R + + ++ + Q SL +S+ Y A
Sbjct: 618 VSVYQIVVEEERPRR---------TKKTTEILKCYPVPIHFQNASLLNSQY------YFA 662
Query: 784 ARFSV----LPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT------FAAS 833
A F F GD K Y G+ N L P Y ++ A + + T A
Sbjct: 663 AEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATK 722
Query: 834 PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR 893
+ P + P+P+ D + VI +L V II + + +++ K K KRK++
Sbjct: 723 GAATPKPV--PEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKETMSS 779
Query: 894 TK 895
T+
Sbjct: 780 TR 781
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 473 bits (1217), Expect = e-133
Identities = 251/604 (41%), Positives = 368/604 (60%), Gaps = 19/604 (3%)
Query: 905 PHHPKDPVEMR--RINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQ 962
P+ DPVEM R FQ P I +AD+ +H ++K +EYE++ GQ
Sbjct: 868 PYRTCDPVEMSYPRDQFQ-------PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQT 920
Query: 963 FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQ 1022
+W+ + + N+ KNRY N+I+YDHSRV L ++G SDYINANY+DGY YIATQ
Sbjct: 921 ASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQ 980
Query: 1023 GPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIE 1082
GP+ ET DFWRM+W++ SA+IVM+T L E R+KC +YWP+ TE YG I+VTL++T
Sbjct: 981 GPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIETEP 1039
Query: 1083 LATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPI 1142
LA + +RTF++ K G E RE+R F FT+WPDHGVP Y T L F+R+VK NPP+AGPI
Sbjct: 1040 LAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPI 1099
Query: 1143 VVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1202
VVHCSAG GRTGCFI ID ML+ + E VD++ V +R+QR +VQTE+QY F+H+A+
Sbjct: 1100 VVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1159
Query: 1203 LEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLP 1260
LEA CGNT +P + +++++P + + ++ EF+ L + LP
Sbjct: 1160 LEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLP 1219
Query: 1261 CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1320
N KNR ++++P + L + G E S+YINA+ +D ++Q A++ TQ PL T D
Sbjct: 1220 RNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVAD 1278
Query: 1321 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1380
FWR++++ N + VVML ++ + C QYWP + S Y V+ ++ I R F
Sbjct: 1279 FWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIF 1336
Query: 1381 KVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVH 1436
++ + Q R V+ Q+ WP + P S + + ++ K +EQ+ G++G VH
Sbjct: 1337 RICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVH 1396
Query: 1437 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 1496
C G GR+G F + V E ++ + ++D+F VK LR + MV+T ++Y+F Y+ ALEY
Sbjct: 1397 CLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY 1456
Query: 1497 LGSF 1500
L SF
Sbjct: 1457 LSSF 1460
Score = 85.9 bits (211), Expect = 3e-16
Identities = 109/420 (25%), Positives = 174/420 (41%), Gaps = 49/420 (11%)
Query: 225 VRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK-WMQ---GAEDLTPED 280
VR L R AP F L + E+ G N C+A G + K W+Q G +
Sbjct: 182 VRVLAHPCRKAPHFLRL-QNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT 240
Query: 281 DMPVGRNVLELTDVKDSAN-----YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTEN 334
+ R V D+A Y CV S G + A++ VK P P E
Sbjct: 241 RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---EL 297
Query: 335 TATSITITWDSGNPD------PVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSE 388
A T W N + P+ +EY++ + G + + + Y + L P+ E
Sbjct: 298 LAVGATYLWIKPNANSIIGDGPIILKEVEYRTTT--GTWAETHIVDSPNYKLWHLDPDVE 355
Query: 389 YEIWV--SAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNG 446
YEI V + G GPP + TRT P P+NV+ + A + +QW EP G
Sbjct: 356 YEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFG 411
Query: 447 --LIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLED--ETYTVRVLAFTSVGDGP 502
+ R + T++ ++ V N Q++ ++ + T+ L T+R+ S +G
Sbjct: 412 YAVTRCHSYNLTVQYQY-VFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGR 470
Query: 503 L-SDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFR------ 552
+ S+ + V+T++ VPG P+ E I + W PP + + I YE+ ++
Sbjct: 471 MESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLD 530
Query: 553 -EGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSIS 609
D + G+ F T ++ L P T Y+F + A + +G G P V R IS
Sbjct: 531 PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFG---PPVTTRIATKIS 587
>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
precursor [Homo sapiens]
Length = 1436
Score = 462 bits (1189), Expect = e-129
Identities = 351/1114 (31%), Positives = 521/1114 (46%), Gaps = 134/1114 (12%)
Query: 485 DETYTVRVLAFTSVGDGPLS---DPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPR 540
D Y + VL T GDG P+ +T+ P + P L +TL W P
Sbjct: 350 DTEYEISVL-LTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLG 408
Query: 541 QESI----------IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSP 590
Y L RE +T + Y +++L P RL +P
Sbjct: 409 YNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNP 468
Query: 591 QGLGAFTPVVRQRTLQSISPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNG 645
+G V Q T + + P + + ++ + L WE P N T Y+I Y
Sbjct: 469 EGRKEGKEVTFQ-TDEDV-PSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQS 526
Query: 646 L-----TLDVDG--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTA 688
+ ++V G RT KL ++L P T Y F + T +G L + T
Sbjct: 527 IESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTN 586
Query: 689 WTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQF 742
+A + + +P +++ I V L Q P+ Y +++ LR+ GGQ
Sbjct: 587 ISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQD 645
Query: 743 LTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQ 800
P+ + L R L H E+ S LP F GD +
Sbjct: 646 CFPVPLTFEAALA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQT 687
Query: 801 YGGFDNRGLEPGHRYVLFVLAVLQ-KSEPTFAASPFSDPFQL-DNPDPQPIVDGEEGLIW 858
Y GF N LEP Y+++ A K E + ++ P + E +
Sbjct: 688 YRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGL 747
Query: 859 VIGPV---LAVVFIICIVIAILLYKNKPDSKRKDS------------------------- 890
++G LAV+ ++ I +++ K KP + K +
Sbjct: 748 ILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQ 807
Query: 891 -------------------EPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIP 931
+ R+ + + L P+ P + + T G L HP +
Sbjct: 808 EDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHT-GQL-HPAVR 865
Query: 932 IADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVI 991
+AD+ +H ++K + QEYES G W+ + + +R + AYD RV
Sbjct: 866 VADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVK 921
Query: 992 LQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLE 1051
L P+ G +DYINANY+DGY N +IATQGP PE DFWRMVW++ ++IVM+T+L
Sbjct: 922 LHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLV 981
Query: 1052 EKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTA 1111
E R+KC +YWP ++TYG I++ L+ T LA + VRTF+L + G S + EVRQF FTA
Sbjct: 982 EVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTA 1040
Query: 1112 WPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKT 1171
WP+HGVP + T LAF+RRVK PPDAGPIV+HCSAG GRTGC+IV+D ML+ + E
Sbjct: 1041 WPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGV 1100
Query: 1172 VDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPG 1231
VD+Y V + S+R M+QTE+QY FIH+A+LEA CG T +P A +++ +++P
Sbjct: 1101 VDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQ 1160
Query: 1232 EHVTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG 1289
+ + + EF+ L A LP N+ KNR ++++P + CL + +G
Sbjct: 1161 SNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFLISTDG 1217
Query: 1290 --SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGRE-K 1346
++YINA+ D Y + A+I T PL TT DFWR++++ T +VML +L +
Sbjct: 1218 DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWP 1277
Query: 1347 CHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE- 1403
C QYWP +Y V+ M+ + R F+V + Q VR FQF W
Sbjct: 1278 CLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAY 1337
Query: 1404 QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVV 1463
+ P S + F+ + +V K + + G DG VHC G GR+G F + VLE +R +V
Sbjct: 1338 RDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLV 1396
Query: 1464 DIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1497
D+F K LR +P MV+T D+Y FCY ALEYL
Sbjct: 1397 DVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1430
Score = 63.5 bits (153), Expect = 1e-09
Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)
Query: 300 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 355
Y CV+ + G + A++ VK P P + T + I ++ + P+
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Query: 356 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 413
IEY+ GP+ ++ Y + L P++EYEI V + G G P +++RT
Sbjct: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
Query: 414 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 473
P AP+ + + A + +QW EP+ N + R + ++ + +G+ + +
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437
Query: 474 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 526
+ T T+ +LL VR L T+ + +T + VP + AE+
Sbjct: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493
Query: 527 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 571
+ E I L W P++ + I +YE+ ++ + P T +V
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
Query: 572 VEDLKPNTEYAFRLAARSPQGLG 594
+L P T Y F + AR+ +G G
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFG 576
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 456 bits (1173), Expect = e-128
Identities = 267/687 (38%), Positives = 378/687 (55%), Gaps = 55/687 (8%)
Query: 858 WVIGPVL--AVVFI-ICIVIAILLY----------------KNKPDSKRKDSEPRTKCLL 898
W+I ++ A+ F+ + ++IA+L+Y + P S + + KC
Sbjct: 737 WIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCF- 795
Query: 899 NNADLAPHHPKDPVEMRRINFQTPGMLSHPP----IPIADMAEHTERLKANDSLKLSQEY 954
A + +D R + ++ ++ P IP+ +H L +N+ S+++
Sbjct: 796 ---QTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDF 852
Query: 955 ESID---PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG--IMGSDYINANYV 1009
E + T EHSN NK KNRY N++AYDHSRV L+P+ G SDYINANYV
Sbjct: 853 EEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYV 912
Query: 1010 DGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTET 1069
DGY AYIATQGPL TF DFWRM+WEQ + IVM+T L EK R KCDQYWP +E
Sbjct: 913 DGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEE 972
Query: 1070 YGFIQVTLLDTIELATFCVRTFSLHKN-----------GSSEKREVRQFQFTAWPDHGVP 1118
YG I VTL T A + VR FS+ G +R V Q+ +T WPD GVP
Sbjct: 973 YGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVP 1032
Query: 1119 EYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHV 1178
EY P L F+RR P+ GP++VHCSAGVGRTG +IVID+ML++IK + TV+V G +
Sbjct: 1033 EYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFL 1092
Query: 1179 TLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGME 1238
+R+QRNY+VQTE+QY FIH+ALLEA+ TEV + L++Y+ + G T +E
Sbjct: 1093 KHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVGGK-TRLE 1151
Query: 1239 LEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFI 1298
+FK + A SA CNK KNR +++P E RV L P+ G++G+DYINAS+I
Sbjct: 1152 KQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYI 1211
Query: 1299 DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA-ERSA 1357
GY + +I TQ PL TT+DFWRM+W++N+ I+VML + + ++ YWP+ E S
Sbjct: 1212 MGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREESM 1270
Query: 1358 RYQYFVV-----DPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEG 1412
+ F V D + N Q I+ +F + +D VR FQ WP P S
Sbjct: 1271 NCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST- 1329
Query: 1413 FIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKML 1472
+ I + +E +DGP VH G G+ L+ + +++ E VD+FQ KM+
Sbjct: 1330 -FELINVI--KEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMI 1386
Query: 1473 RTQRPAMVQTEDEYQFCYQAALEYLGS 1499
RP + ++YQF Y+A L + +
Sbjct: 1387 NLMRPGVFTDIEQYQFIYKAMLSLVST 1413
Score = 34.7 bits (78), Expect = 0.71
Identities = 18/92 (19%), Positives = 41/92 (44%), Gaps = 7/92 (7%)
Query: 503 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS-------PPRQESIIKYELLFREGD 555
L +P+ + + P++++ + ++T++ +SWS PP +I Y E +
Sbjct: 334 LENPLGTEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDE 393
Query: 556 HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA 587
+ + D + + P++ Y FR+ A
Sbjct: 394 KEKTFTKDSDKDLKATISHVSPDSLYLFRVQA 425
>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
precursor [Homo sapiens]
Length = 1442
Score = 456 bits (1172), Expect = e-127
Identities = 351/1120 (31%), Positives = 521/1120 (46%), Gaps = 140/1120 (12%)
Query: 485 DETYTVRVLAFTSVGDGPLS---DPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPR 540
D Y + VL T GDG P+ +T+ P + P L +TL W P
Sbjct: 350 DTEYEISVL-LTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLG 408
Query: 541 QESI----------IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSP 590
Y L RE +T + Y +++L P RL +P
Sbjct: 409 YNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNP 468
Query: 591 QGLGAFTPVVRQRTLQSISPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNG 645
+G V Q T + + P + + ++ + L WE P N T Y+I Y
Sbjct: 469 EGRKEGKEVTFQ-TDEDV-PSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQS 526
Query: 646 L-----TLDVDG--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTA 688
+ ++V G RT KL ++L P T Y F + T +G L + T
Sbjct: 527 IESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTN 586
Query: 689 WTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQF 742
+A + + +P +++ I V L Q P+ Y +++ LR+ GGQ
Sbjct: 587 ISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQD 645
Query: 743 LTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQ 800
P+ + L R L H E+ S LP F GD +
Sbjct: 646 CFPVPLTFEAALA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQT 687
Query: 801 YGGFDNRGLEPGHRYVLFVLAVLQ-KSEPTFAASPFSDPFQL-DNPDPQPIVDGEEGLIW 858
Y GF N LEP Y+++ A K E + ++ P + E +
Sbjct: 688 YRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGL 747
Query: 859 VIGPV---LAVVFIICIVIAILLYKNKPDSKRKDS------------------------- 890
++G LAV+ ++ I +++ K KP + K +
Sbjct: 748 ILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQ 807
Query: 891 -------------------EPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIP 931
+ R+ + + L P+ P + + T G L HP +
Sbjct: 808 EDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHT-GQL-HPAVR 865
Query: 932 IADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVI 991
+AD+ +H ++K + QEYES G W+ + + +R + AYD RV
Sbjct: 866 VADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVK 921
Query: 992 LQPIEGIMGSDYINANYVD------GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIV 1045
L P+ G +DYINANY+D GY N +IATQGP PE DFWRMVW++ ++IV
Sbjct: 922 LHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIV 981
Query: 1046 MMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVR 1105
M+T+L E R+KC +YWP ++TYG I++ L+ T LA + VRTF+L + G S + EVR
Sbjct: 982 MITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVR 1040
Query: 1106 QFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLER 1165
QF FTAWP+HGVP + T LAF+RRVK PPDAGPIV+HCSAG GRTGC+IV+D ML+
Sbjct: 1041 QFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDM 1100
Query: 1166 IKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKL 1225
+ E VD+Y V + S+R M+QTE+QY FIH+A+LEA CG T +P A +++
Sbjct: 1101 AECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEM 1160
Query: 1226 AQVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQP 1283
+++P + + + EF+ L A LP N+ KNR ++++P + CL
Sbjct: 1161 IRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPF 1217
Query: 1284 IRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLRE 1341
+ +G ++YINA+ D Y + A+I T PL TT DFWR++++ T +VML +L +
Sbjct: 1218 LISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQ 1277
Query: 1342 MGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQF 1398
C QYWP +Y V+ M+ + R F+V + Q VR FQF
Sbjct: 1278 SNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQF 1337
Query: 1399 TDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM 1457
W + P S + F+ + +V K + + G DG VHC G GR+G F + VLE +
Sbjct: 1338 LRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMI 1396
Query: 1458 RYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1497
R +VD+F K LR +P MV+T D+Y FCY ALEYL
Sbjct: 1397 RCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1436
Score = 63.5 bits (153), Expect = 1e-09
Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)
Query: 300 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 355
Y CV+ + G + A++ VK P P + T + I ++ + P+
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Query: 356 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 413
IEY+ GP+ ++ Y + L P++EYEI V + G G P +++RT
Sbjct: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
Query: 414 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 473
P AP+ + + A + +QW EP+ N + R + ++ + +G+ + +
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437
Query: 474 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 526
+ T T+ +LL VR L T+ + +T + VP + AE+
Sbjct: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493
Query: 527 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 571
+ E I L W P++ + I +YE+ ++ + P T +V
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
Query: 572 VEDLKPNTEYAFRLAARSPQGLG 594
+L P T Y F + AR+ +G G
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFG 576
>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
precursor [Homo sapiens]
Length = 1446
Score = 445 bits (1145), Expect = e-124
Identities = 240/579 (41%), Positives = 340/579 (58%), Gaps = 17/579 (2%)
Query: 927 HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 986
HP + +AD+ +H ++K + QEYES G W+ + + +R + AYD
Sbjct: 871 HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYD 926
Query: 987 HSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVM 1046
RV L P+ G +DYINANY+DGY N +IATQGP PE DFWRMVW++ ++IVM
Sbjct: 927 RHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVM 986
Query: 1047 MTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1106
+T+L E R+KC +YWP ++TYG I++ L+ T LA + VRTF+L + G S + EVRQ
Sbjct: 987 ITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQ 1045
Query: 1107 FQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI 1166
F FTAWP+HGVP + T LAF+RRVK PPDAGPIV+HCSAG GRTGC+IV+D ML+
Sbjct: 1046 FHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMA 1105
Query: 1167 KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA 1226
+ E VD+Y V + S+R M+QTE+QY FIH+A+LEA CG T +P A +++
Sbjct: 1106 ECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMI 1165
Query: 1227 QVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1284
+++P + + + EF+ L A LP N+ KNR ++++P + CL +
Sbjct: 1166 RIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFL 1222
Query: 1285 RGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREM 1342
+G ++YINA+ D Y + A+I T PL TT DFWR++++ T +VML +L +
Sbjct: 1223 ISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQS 1282
Query: 1343 GRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFT 1399
C QYWP +Y V+ M+ + R F+V + Q VR FQF
Sbjct: 1283 NSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFL 1342
Query: 1400 DWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMR 1458
W + P S + F+ + +V K + + G DG VHC G GR+G F + VLE +R
Sbjct: 1343 RWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIR 1401
Query: 1459 YEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1497
+VD+F K LR +P MV+T D+Y FCY ALEYL
Sbjct: 1402 CHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1440
Score = 63.5 bits (153), Expect = 1e-09
Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)
Query: 300 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 355
Y CV+ + G + A++ VK P P + T + I ++ + P+
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Query: 356 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 413
IEY+ GP+ ++ Y + L P++EYEI V + G G P +++RT
Sbjct: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
Query: 414 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 473
P AP+ + + A + +QW EP+ N + R + ++ + +G+ + +
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437
Query: 474 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 526
+ T T+ +LL VR L T+ + +T + VP + AE+
Sbjct: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493
Query: 527 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 571
+ E I L W P++ + I +YE+ ++ + P T +V
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
Query: 572 VEDLKPNTEYAFRLAARSPQGLG 594
+L P T Y F + AR+ +G G
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFG 576
Score = 42.4 bits (98), Expect = 0.003
Identities = 91/381 (23%), Positives = 139/381 (36%), Gaps = 66/381 (17%)
Query: 485 DETYTVRVLAFTSVGDGPLS---DPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPR 540
D Y + VL T GDG P+ +T+ P + P L +TL W P
Sbjct: 350 DTEYEISVL-LTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLG 408
Query: 541 QESI----------IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSP 590
Y L RE +T + Y +++L P RL +P
Sbjct: 409 YNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNP 468
Query: 591 QGLGAFTPVVRQRTLQSISPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNG 645
+G V Q T + + P + + ++ + L WE P N T Y+I Y
Sbjct: 469 EGRKEGKEVTFQ-TDEDV-PSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQS 526
Query: 646 L-----TLDVDG--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTA 688
+ ++V G RT KL ++L P T Y F + T +G L + T
Sbjct: 527 IESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTN 586
Query: 689 WTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQF 742
+A + + +P +++ I V L Q P+ Y +++ LR+ GGQ
Sbjct: 587 ISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQD 645
Query: 743 LTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQ 800
P+ + L R L H E+ S LP F GD +
Sbjct: 646 CFPVPLTFEAALA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQT 687
Query: 801 YGGFDNRGLEPGHRYVLFVLA 821
Y GF N LEP Y+++ A
Sbjct: 688 YRGFWNPPLEPRKAYLIYFQA 708
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 412 bits (1058), Expect = e-114
Identities = 241/592 (40%), Positives = 336/592 (56%), Gaps = 24/592 (4%)
Query: 925 LSHPPIPIADMAEHTERLKANDSLK-LSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVI 983
+ H P +AD+ + + ++LK QE +S T + SN NK KNRY N++
Sbjct: 1701 IKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIV 1760
Query: 984 AYDHSRVILQPIEGIMG--SDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRS 1041
AYDHSRV L + G +DYINANYVDGY AYIA QGPL T DFWRM+WE
Sbjct: 1761 AYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNV 1820
Query: 1042 ATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLH----KNG 1097
IVM+T L EK R KCDQYWP G+E YG VT LA + VR F+L K G
Sbjct: 1821 EVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKG 1880
Query: 1098 SSEKRE----VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRT 1153
S + R V Q+ +T WPD GVPEY P L F+R+ GP+VVHCSAGVGRT
Sbjct: 1881 SQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRT 1940
Query: 1154 GCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1213
G +IV+D+ML++I+ E TV+++G + +RSQRNY+VQTE+QY FIH+ L+EA+ TEV
Sbjct: 1941 GTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV 2000
Query: 1214 PARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMP 1273
++AY+ L P T +E +F+ L+ S S + +A CN+ KNR +I+P
Sbjct: 2001 LDSHIHAYVNALLIPGPAGK-TKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIP 2059
Query: 1274 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIV 1333
E +RV + + G EG+DYINAS+I GY Q +I TQ PL T +DFWRM+W++N+ +V
Sbjct: 2060 VERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV 2118
Query: 1334 VMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE-----YNMPQYILREFKVTDARD 1387
VM+ + M ++ YWP + + F V MAE N + I+++F + +D
Sbjct: 2119 VMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQD 2177
Query: 1388 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVF 1447
VR FQ WP P S + I + +E +DGP+ VH G G F
Sbjct: 2178 DYVLEVRHFQCPKWPNPDSPISKT--FELISVI--KEEAANRDGPMIVHDEHGGVTAGTF 2233
Query: 1448 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1499
L+ ++ ++ E VD++Q KM+ RP + ++YQF Y+ L + +
Sbjct: 2234 CALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST 2285
Score = 117 bits (292), Expect = 1e-25
Identities = 79/278 (28%), Positives = 133/278 (47%), Gaps = 12/278 (4%)
Query: 949 KLSQEYESIDPG--QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINA 1006
KL ++++ + QQ + + + N+ KNR +++I + SRV + + G G+DYINA
Sbjct: 2022 KLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINA 2080
Query: 1007 NYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG 1066
+Y+ GY N +I TQ PL T DFWRM+W+ + +VM+ + + + YWPN+
Sbjct: 2081 SYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKD 2139
Query: 1067 TE-TYGFIQVTLLDTIELAT-----FCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEY 1120
+VTL+ ++ F L EVR FQ WP+ P
Sbjct: 2140 EPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPIS 2199
Query: 1121 PTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTL 1180
T L + + + N GP++VH G G F + ++ +++ E +VDVY +
Sbjct: 2200 KTFELISVIKEEAANRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKM 2257
Query: 1181 MRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSL 1218
+ R + +QY F+++ +L V E P+ SL
Sbjct: 2258 INLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSL 2295
Score = 33.1 bits (74), Expect = 2.1
Identities = 22/84 (26%), Positives = 41/84 (48%), Gaps = 9/84 (10%)
Query: 518 QPMNLRAEARSETSITLSWSPPR---QESIIKYELLFREGDHGREVGRTFDPTTSY---- 570
+P N++A+ + TS+ ++W PR I K+ +L+++ D + F T Y
Sbjct: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEF-LTDGYQDLG 372
Query: 571 -VVEDLKPNTEYAFRLAARSPQGL 593
++ +L PN Y ++ A GL
Sbjct: 373 AILNNLLPNMSYVLQIVAICTNGL 396
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
precursor [Homo sapiens]
Length = 1256
Score = 397 bits (1019), Expect = e-110
Identities = 235/598 (39%), Positives = 333/598 (55%), Gaps = 33/598 (5%)
Query: 924 MLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANV 982
+++ PI + E +R A++ E++SI +F + + N+ KNRY ++
Sbjct: 577 LMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDI 636
Query: 983 IAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSA 1042
+ YD++RV L I G GS+YINA+Y+DG++ YIA QGP ET DFWRM+WEQ++
Sbjct: 637 LPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKAT 696
Query: 1043 TIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNGSS 1099
IVM+TR EE +R KC +YWP+ GT +G + V + + ++ ++ +K +
Sbjct: 697 VIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA 756
Query: 1100 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1159
REV QFT+WPDHGVPE P L RRV + +GPIVVHCSAGVGRTG +I I
Sbjct: 757 TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGI 816
Query: 1160 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1219
DAMLE ++ E VDVYG+V +R QR MVQ E QY IH+AL+E G TEV L+
Sbjct: 817 DAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELH 876
Query: 1220 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1279
Y+ + + +P + +E EF+RL + ++ ++ I N NK KNR N++PY+ RV
Sbjct: 877 PYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRV 935
Query: 1280 CLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1320
L+ E S YINASFI Y + + IA QGPL ET D
Sbjct: 936 PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGD 995
Query: 1321 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1380
FW+M+++ ++VMLT+L+ +E C QYW E Y VD Y LR F
Sbjct: 996 FWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF 1054
Query: 1381 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------P 1432
++ ++ SRTV Q+Q+T+W + +P + I I V K ++ +G P
Sbjct: 1055 ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTP 1114
Query: 1433 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1490
+ +HC G +TG+F L +LE E VVDIFQ VK LR RP MV T ++YQF Y
Sbjct: 1115 LLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172
Score = 198 bits (503), Expect = 4e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 1257 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1316
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 622 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681
Query: 1317 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1374
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 682 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741
Query: 1375 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1433
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 742 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799
Query: 1434 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1493
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E +Y +QA
Sbjct: 800 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
Query: 1494 LEY 1496
+EY
Sbjct: 860 VEY 862
Score = 155 bits (392), Expect = 3e-37
Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)
Query: 950 LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 993
L E++ + + + +H N E NK KNR +NVI YD++RV L+
Sbjct: 894 LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 953
Query: 994 ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1049
+ S YINA+++ Y IA QGPL ET GDFW+M+++++ IVM+T
Sbjct: 954 SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 1013
Query: 1050 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1109
L+ + C QYW G +TYG I+V L DT + +T+ +R F L + + R V Q+Q+
Sbjct: 1014 LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 1072
Query: 1110 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1159
T W +P P ++ ++ VK P + P+++HC G +TG F +
Sbjct: 1073 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1132
Query: 1160 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1213
+LE + E+ VD++ V +R R MV T +QY F+++ + N +V
Sbjct: 1133 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1186
Score = 32.3 bits (72), Expect = 3.5
Identities = 20/79 (25%), Positives = 38/79 (48%), Gaps = 2/79 (2%)
Query: 509 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 568
+KT G PG+P + + + ++W+PP Q S + L + + + ++
Sbjct: 335 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 392
Query: 569 SYVVEDLKPNTEYAFRLAA 587
Y +++LKP T+Y L A
Sbjct: 393 KYDLQNLKPYTKYVLSLHA 411
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
precursor [Homo sapiens]
Length = 1304
Score = 397 bits (1019), Expect = e-110
Identities = 235/598 (39%), Positives = 333/598 (55%), Gaps = 33/598 (5%)
Query: 924 MLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANV 982
+++ PI + E +R A++ E++SI +F + + N+ KNRY ++
Sbjct: 625 LMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDI 684
Query: 983 IAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSA 1042
+ YD++RV L I G GS+YINA+Y+DG++ YIA QGP ET DFWRM+WEQ++
Sbjct: 685 LPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKAT 744
Query: 1043 TIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNGSS 1099
IVM+TR EE +R KC +YWP+ GT +G + V + + ++ ++ +K +
Sbjct: 745 VIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA 804
Query: 1100 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1159
REV QFT+WPDHGVPE P L RRV + +GPIVVHCSAGVGRTG +I I
Sbjct: 805 TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGI 864
Query: 1160 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1219
DAMLE ++ E VDVYG+V +R QR MVQ E QY IH+AL+E G TEV L+
Sbjct: 865 DAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELH 924
Query: 1220 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1279
Y+ + + +P + +E EF+RL + ++ ++ I N NK KNR N++PY+ RV
Sbjct: 925 PYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRV 983
Query: 1280 CLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1320
L+ E S YINASFI Y + + IA QGPL ET D
Sbjct: 984 PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGD 1043
Query: 1321 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1380
FW+M+++ ++VMLT+L+ +E C QYW E Y VD Y LR F
Sbjct: 1044 FWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF 1102
Query: 1381 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------P 1432
++ ++ SRTV Q+Q+T+W + +P + I I V K ++ +G P
Sbjct: 1103 ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTP 1162
Query: 1433 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1490
+ +HC G +TG+F L +LE E VVDIFQ VK LR RP MV T ++YQF Y
Sbjct: 1163 LLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1220
Score = 198 bits (503), Expect = 4e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 1257 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1316
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 670 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 729
Query: 1317 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1374
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 730 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 789
Query: 1375 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1433
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 790 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 847
Query: 1434 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1493
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E +Y +QA
Sbjct: 848 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907
Query: 1494 LEY 1496
+EY
Sbjct: 908 VEY 910
Score = 155 bits (392), Expect = 3e-37
Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)
Query: 950 LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 993
L E++ + + + +H N E NK KNR +NVI YD++RV L+
Sbjct: 942 LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 1001
Query: 994 ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1049
+ S YINA+++ Y IA QGPL ET GDFW+M+++++ IVM+T
Sbjct: 1002 SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 1061
Query: 1050 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1109
L+ + C QYW G +TYG I+V L DT + +T+ +R F L + + R V Q+Q+
Sbjct: 1062 LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 1120
Query: 1110 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1159
T W +P P ++ ++ VK P + P+++HC G +TG F +
Sbjct: 1121 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1180
Query: 1160 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1213
+LE + E+ VD++ V +R R MV T +QY F+++ + N +V
Sbjct: 1181 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1234
Score = 32.3 bits (72), Expect = 3.5
Identities = 20/79 (25%), Positives = 38/79 (48%), Gaps = 2/79 (2%)
Query: 509 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 568
+KT G PG+P + + + ++W+PP Q S + L + + + ++
Sbjct: 383 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 440
Query: 569 SYVVEDLKPNTEYAFRLAA 587
Y +++LKP T+Y L A
Sbjct: 441 KYDLQNLKPYTKYVLSLHA 459
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
precursor [Homo sapiens]
Length = 1143
Score = 397 bits (1019), Expect = e-110
Identities = 235/598 (39%), Positives = 333/598 (55%), Gaps = 33/598 (5%)
Query: 924 MLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANV 982
+++ PI + E +R A++ E++SI +F + + N+ KNRY ++
Sbjct: 464 LMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDI 523
Query: 983 IAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSA 1042
+ YD++RV L I G GS+YINA+Y+DG++ YIA QGP ET DFWRM+WEQ++
Sbjct: 524 LPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKAT 583
Query: 1043 TIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNGSS 1099
IVM+TR EE +R KC +YWP+ GT +G + V + + ++ ++ +K +
Sbjct: 584 VIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA 643
Query: 1100 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1159
REV QFT+WPDHGVPE P L RRV + +GPIVVHCSAGVGRTG +I I
Sbjct: 644 TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGI 703
Query: 1160 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1219
DAMLE ++ E VDVYG+V +R QR MVQ E QY IH+AL+E G TEV L+
Sbjct: 704 DAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELH 763
Query: 1220 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1279
Y+ + + +P + +E EF+RL + ++ ++ I N NK KNR N++PY+ RV
Sbjct: 764 PYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRV 822
Query: 1280 CLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1320
L+ E S YINASFI Y + + IA QGPL ET D
Sbjct: 823 PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGD 882
Query: 1321 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1380
FW+M+++ ++VMLT+L+ +E C QYW E Y VD Y LR F
Sbjct: 883 FWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF 941
Query: 1381 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------P 1432
++ ++ SRTV Q+Q+T+W + +P + I I V K ++ +G P
Sbjct: 942 ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTP 1001
Query: 1433 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1490
+ +HC G +TG+F L +LE E VVDIFQ VK LR RP MV T ++YQF Y
Sbjct: 1002 LLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059
Score = 198 bits (503), Expect = 4e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 1257 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1316
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568
Query: 1317 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1374
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 569 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628
Query: 1375 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1433
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 629 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686
Query: 1434 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1493
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E +Y +QA
Sbjct: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
Query: 1494 LEY 1496
+EY
Sbjct: 747 VEY 749
Score = 155 bits (392), Expect = 3e-37
Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)
Query: 950 LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 993
L E++ + + + +H N E NK KNR +NVI YD++RV L+
Sbjct: 781 LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 840
Query: 994 ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1049
+ S YINA+++ Y IA QGPL ET GDFW+M+++++ IVM+T
Sbjct: 841 SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 900
Query: 1050 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1109
L+ + C QYW G +TYG I+V L DT + +T+ +R F L + + R V Q+Q+
Sbjct: 901 LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 959
Query: 1110 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1159
T W +P P ++ ++ VK P + P+++HC G +TG F +
Sbjct: 960 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1019
Query: 1160 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1213
+LE + E+ VD++ V +R R MV T +QY F+++ + N +V
Sbjct: 1020 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1073
Score = 32.3 bits (72), Expect = 3.5
Identities = 20/79 (25%), Positives = 38/79 (48%), Gaps = 2/79 (2%)
Query: 509 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 568
+KT G PG+P + + + ++W+PP Q S + L + + + ++
Sbjct: 222 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 279
Query: 569 SYVVEDLKPNTEYAFRLAA 587
Y +++LKP T+Y L A
Sbjct: 280 KYDLQNLKPYTKYVLSLHA 298
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,491,696
Number of Sequences: 37866
Number of extensions: 3075355
Number of successful extensions: 15809
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 328
Number of HSP's successfully gapped in prelim test: 208
Number of HSP's that attempted gapping in prelim test: 6395
Number of HSP's gapped (non-prelim): 3486
length of query: 1505
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1390
effective length of database: 13,892,928
effective search space: 19311169920
effective search space used: 19311169920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.