Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 104487295
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
(1501 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 3060 0.0
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 3054 0.0
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 2338 0.0
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 2325 0.0
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 1912 0.0
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 1897 0.0
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 1541 0.0
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 1541 0.0
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 1541 0.0
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 1407 0.0
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 1405 0.0
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 592 e-168
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 589 e-168
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 589 e-168
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor... 552 e-157
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo... 549 e-156
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 521 e-147
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 514 e-145
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 506 e-143
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 498 e-140
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 498 e-140
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 473 e-133
gi|110735404 protein tyrosine phosphatase, receptor type, U isof... 462 e-129
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 456 e-128
gi|110735406 protein tyrosine phosphatase, receptor type, U isof... 456 e-127
gi|110735402 protein tyrosine phosphatase, receptor type, U isof... 445 e-124
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 412 e-114
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 397 e-110
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 397 e-110
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 397 e-110
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 3060 bits (7933), Expect = 0.0
Identities = 1501/1501 (100%), Positives = 1501/1501 (100%)
Query: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP
Sbjct: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
Query: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA
Sbjct: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
Query: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS
Sbjct: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
Query: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS 240
NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS
Sbjct: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS 240
Query: 241 HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA 300
HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA
Sbjct: 241 HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA 300
Query: 301 MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD 360
MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD
Sbjct: 301 MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD 360
Query: 361 GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420
GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV
Sbjct: 361 GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420
Query: 421 QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480
QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE
Sbjct: 421 QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480
Query: 481 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 540
DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI
Sbjct: 481 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 540
Query: 541 IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT 600
IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT
Sbjct: 541 IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT 600
Query: 601 LQSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKP 660
LQSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKP
Sbjct: 601 LQSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKP 660
Query: 661 HTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPV 720
HTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPV
Sbjct: 661 HTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPV 720
Query: 721 QSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAA 780
QSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAA
Sbjct: 721 QSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAA 780
Query: 781 RFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQLDNP 840
RFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQLDNP
Sbjct: 781 RFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQLDNP 840
Query: 841 DPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLA 900
DPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLA
Sbjct: 841 DPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLA 900
Query: 901 PHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFT 960
PHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFT
Sbjct: 901 PHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFT 960
Query: 961 WEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGP 1020
WEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGP
Sbjct: 961 WEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGP 1020
Query: 1021 LPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELA 1080
LPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELA
Sbjct: 1021 LPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELA 1080
Query: 1081 TFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVV 1140
TFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVV
Sbjct: 1081 TFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVV 1140
Query: 1141 HCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE 1200
HCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
Sbjct: 1141 HCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE 1200
Query: 1201 AVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKF 1260
AVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKF
Sbjct: 1201 AVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKF 1260
Query: 1261 KNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRM 1320
KNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRM
Sbjct: 1261 KNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRM 1320
Query: 1321 LWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD 1380
LWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD
Sbjct: 1321 LWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD 1380
Query: 1381 ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRT 1440
ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRT
Sbjct: 1381 ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRT 1440
Query: 1441 GVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA 1500
GVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA
Sbjct: 1441 GVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA 1500
Query: 1501 T 1501
T
Sbjct: 1501 T 1501
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 3054 bits (7918), Expect = 0.0
Identities = 1501/1505 (99%), Positives = 1501/1505 (99%), Gaps = 4/1505 (0%)
Query: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP
Sbjct: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
Query: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA
Sbjct: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
Query: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS
Sbjct: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
Query: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSI 236
NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVR VRRVAPRFSI
Sbjct: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSI 240
Query: 237 LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY 296
LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY
Sbjct: 241 LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY 300
Query: 297 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 356
TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS
Sbjct: 301 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 360
Query: 357 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 416
KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA
Sbjct: 361 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 420
Query: 417 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 476
PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG
Sbjct: 421 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 480
Query: 477 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR 536
SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR
Sbjct: 481 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR 540
Query: 537 QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV 596
QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV
Sbjct: 541 QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV 600
Query: 597 RQRTLQSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLIT 656
RQRTLQSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLIT
Sbjct: 601 RQRTLQSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLIT 660
Query: 657 HLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQS 716
HLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQS
Sbjct: 661 HLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQS 720
Query: 717 PVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRP 776
PVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRP
Sbjct: 721 PVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRP 780
Query: 777 YIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQ 836
YIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQ
Sbjct: 781 YIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQ 840
Query: 837 LDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN 896
LDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN
Sbjct: 841 LDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN 900
Query: 897 ADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG 956
ADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG
Sbjct: 901 ADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG 960
Query: 957 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIA 1016
QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIA
Sbjct: 961 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIA 1020
Query: 1017 TQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDT 1076
TQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDT
Sbjct: 1021 TQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDT 1080
Query: 1077 IELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG 1136
IELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG
Sbjct: 1081 IELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG 1140
Query: 1137 PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHE 1196
PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHE
Sbjct: 1141 PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHE 1200
Query: 1197 ALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLP 1256
ALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLP
Sbjct: 1201 ALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLP 1260
Query: 1257 CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1316
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED
Sbjct: 1261 CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1320
Query: 1317 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1376
FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF
Sbjct: 1321 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1380
Query: 1377 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAG 1436
KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAG
Sbjct: 1381 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAG 1440
Query: 1437 VGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSF 1496
VGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSF
Sbjct: 1441 VGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSF 1500
Query: 1497 DHYAT 1501
DHYAT
Sbjct: 1501 DHYAT 1505
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 2338 bits (6060), Expect = 0.0
Identities = 1138/1486 (76%), Positives = 1300/1486 (87%), Gaps = 16/1486 (1%)
Query: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
Query: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
Query: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSG------ALQIESSEETDQ 202
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRSG ALQIE SEE+DQ
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSEESDQ 199
Query: 203 GKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSILPMSHEIMPGGNVNITCVAVGS 258
GKYECVATNSAG RYS+PANLYVR VRRV PRFSI P +HEIMPGG+VNITCVAVGS
Sbjct: 200 GKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGS 259
Query: 259 PMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSL 318
PMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITVK+L
Sbjct: 260 PMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKAL 319
Query: 319 PKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGG 378
PK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS+ G
Sbjct: 320 PKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAG 379
Query: 379 LSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV 438
LSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+EP
Sbjct: 380 LSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPE 439
Query: 439 EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 498
EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+GDGP
Sbjct: 440 EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGP 499
Query: 499 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGR 558
LS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 500 LSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRI 559
Query: 559 TFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTS 618
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+QS+ KNF VK +MKTS
Sbjct: 560 TIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTS 619
Query: 619 VLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLG 676
VLLSWE P+NYNS P+KI Y+ + +VDGR T+KLI +LKP Y+FVLTNRG+S G
Sbjct: 620 VLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAG 679
Query: 677 GLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGG 736
GLQ VTA TA ++L KP+ K + DG I V LP+ + ++ Y+I++VPL+KSRG
Sbjct: 680 GLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRG- 738
Query: 737 QFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQ 796
+F+ P SP++M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP F GD K
Sbjct: 739 KFIKPWESPDEMELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKH 796
Query: 797 YGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWV 855
YGGF N+ L+ G YV FVLAV++ +E +A SP+SDP + DPQPI D EEGLIWV
Sbjct: 797 YGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWV 856
Query: 856 IGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINF 915
+GPVLAVVFIICIVIAILLYK+KPD KR +S+ R + NN ++ HHP DPVE+RR+NF
Sbjct: 857 VGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNF 916
Query: 916 QTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRY 975
QTPGM SHPPIPI ++A+H ERLKAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRY
Sbjct: 917 QTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRY 976
Query: 976 ANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQ 1035
ANVIAYDHSRV+L IEGI GSDY+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQ
Sbjct: 977 ANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQ 1036
Query: 1036 RSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSS 1095
RSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSS
Sbjct: 1037 RSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSS 1096
Query: 1096 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1155
EKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVI
Sbjct: 1097 EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVI 1156
Query: 1156 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1215
DAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LY
Sbjct: 1157 DAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLY 1216
Query: 1216 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1275
AYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRV
Sbjct: 1217 AYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1276
Query: 1276 CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKL 1335
CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKL
Sbjct: 1277 CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKL 1336
Query: 1336 REMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1395
REMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT
Sbjct: 1337 REMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1396
Query: 1396 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1455
DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY
Sbjct: 1397 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1456
Query: 1456 EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1501
EGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1457 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1502
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 2325 bits (6024), Expect = 0.0
Identities = 1135/1489 (76%), Positives = 1296/1489 (87%), Gaps = 23/1489 (1%)
Query: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
Query: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
Query: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS---------GALQIESSEE 199
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS GALQIE SEE
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
Query: 200 TDQGKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSILPMSHEIMPGGNVNITCVA 255
+DQGKYECVATNSAG RYS+PANLYVR VRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
Query: 256 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 315
VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319
Query: 316 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 375
K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS
Sbjct: 320 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379
Query: 376 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 435
+ GLSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 380 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439
Query: 436 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 495
EP EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+G
Sbjct: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
Query: 496 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 555
DGPLS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559
Query: 556 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIM 615
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+QS+ KNF VK +M
Sbjct: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVM 619
Query: 616 KTSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGS 673
KTSVLLSWE P+NYNS P+KI Y+ + +VDGR T+KLI +LKP Y+FVLTNRG+
Sbjct: 620 KTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGN 679
Query: 674 SLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKS 733
S GGLQ VTA TA ++L KP+ K + DG I V LP+ + ++ Y+I++VPL+KS
Sbjct: 680 SAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKS 739
Query: 734 RGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGD 793
RG +F+ P SP++M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP F GD
Sbjct: 740 RG-KFIKPWESPDEMELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGD 796
Query: 794 QKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGL 852
K YGGF N+ L+ G YV FVLAV++ +E +A SP+SDP + DPQPI D EEGL
Sbjct: 797 DKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGL 856
Query: 853 IWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRR 912
IWV+GPVLAVVFIICIVIAILLYK K R +S+ R + NN ++ HHP DPVE+RR
Sbjct: 857 IWVVGPVLAVVFIICIVIAILLYKRK----RAESDSRKSSIPNNKEIPSHHPTDPVELRR 912
Query: 913 INFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPK 972
+NFQTPGM SHPPIPI ++A+H ERLKAND+LK SQEYESIDPGQQFTWEHSNLEVNKPK
Sbjct: 913 LNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPK 972
Query: 973 NRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMV 1032
NRYANVIAYDHSRV+L IEGI GSDY+NANY+DGYR QNAYIATQG LPETFGDFWRM+
Sbjct: 973 NRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMI 1032
Query: 1033 WEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKN 1092
WEQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KN
Sbjct: 1033 WEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKN 1092
Query: 1093 GSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCF 1152
GSSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCF
Sbjct: 1093 GSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCF 1152
Query: 1153 IVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPAR 1212
IVIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR
Sbjct: 1153 IVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPAR 1212
Query: 1213 SLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYES 1272
+LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFISANLPCNKFKNRLVNIMPYES
Sbjct: 1213 NLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYES 1272
Query: 1273 TRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVML 1332
TRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE+NSTIVVML
Sbjct: 1273 TRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVML 1332
Query: 1333 TKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQF 1392
TKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQF
Sbjct: 1333 TKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQF 1392
Query: 1393 QFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLER 1452
QFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLER
Sbjct: 1393 QFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLER 1452
Query: 1453 MRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1501
MRYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1453 MRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1501
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 1912 bits (4952), Expect = 0.0
Identities = 985/1266 (77%), Positives = 1047/1266 (82%), Gaps = 36/1266 (2%)
Query: 268 GAEDLTPED--DMPVGRNVLELTDVKDSANY--TCVAMSSLGVIEAVAQITVKS---LPK 320
G+ED P++ +P + L ++ Y T VA + +G + + V++ +P
Sbjct: 649 GSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPS 708
Query: 321 APGTPMVTEN-TATSITITWDSGNPD----PVSYYVIEY---KSKSQDGPYQIKEDITTT 372
AP + E AT+I + W S P + Y + Y + GP +IK+ +
Sbjct: 709 APPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLAD 768
Query: 373 RYS--IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTM 430
I L P + Y I V+A G G S+ V T +VQ ++
Sbjct: 769 AQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQ--QTPEGSL 826
Query: 431 IVQWEEPV-EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVL 489
+ +WE P + GYR+ + E P+ + +D T + + TY R+
Sbjct: 827 LARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRY--TASGVHKGATYVFRLA 884
Query: 490 AFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET-SITLSWSPP----RQESIIKYE 544
A + G G + + + G P L A + ++ L W PP R +I+KY
Sbjct: 885 ARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYT 944
Query: 545 LLFREGD-----HGREVGRTFDP--TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVR 597
+ RE E+ +P + ++ LKP+T Y ++ A + +G G F+P VR
Sbjct: 945 VAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVR 1004
Query: 598 QRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLI 655
RT +SPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLI
Sbjct: 1005 YRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLI 1064
Query: 656 THLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQ 715
THLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQ
Sbjct: 1065 THLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQ 1124
Query: 716 SPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPR 775
SPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPR
Sbjct: 1125 SPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPR 1184
Query: 776 PYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPF 835
PYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPF
Sbjct: 1185 PYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPF 1244
Query: 836 QLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLN 895
QLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLN
Sbjct: 1245 QLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLN 1304
Query: 896 NADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDP 955
NADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDP
Sbjct: 1305 NADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDP 1364
Query: 956 GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYI 1015
GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYI
Sbjct: 1365 GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYI 1424
Query: 1016 ATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLD 1075
ATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLD
Sbjct: 1425 ATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLD 1484
Query: 1076 TIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDA 1135
TIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDA
Sbjct: 1485 TIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDA 1544
Query: 1136 GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIH 1195
GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIH
Sbjct: 1545 GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIH 1604
Query: 1196 EALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANL 1255
EALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANL
Sbjct: 1605 EALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANL 1664
Query: 1256 PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTE 1315
PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTE
Sbjct: 1665 PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTE 1724
Query: 1316 DFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILRE 1375
DFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILRE
Sbjct: 1725 DFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILRE 1784
Query: 1376 FKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA 1435
FKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA
Sbjct: 1785 FKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA 1844
Query: 1436 GVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1495
GVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS
Sbjct: 1845 GVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1904
Query: 1496 FDHYAT 1501
FDHYAT
Sbjct: 1905 FDHYAT 1910
Score = 1227 bits (3175), Expect = 0.0
Identities = 614/648 (94%), Positives = 624/648 (96%), Gaps = 6/648 (0%)
Query: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP
Sbjct: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
Query: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA
Sbjct: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
Query: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS
Sbjct: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
Query: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS 240
NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS
Sbjct: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS 240
Query: 241 HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA 300
HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA
Sbjct: 241 HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA 300
Query: 301 MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD 360
MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD
Sbjct: 301 MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD 360
Query: 361 GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420
GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV
Sbjct: 361 GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420
Query: 421 QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480
QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE
Sbjct: 421 QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480
Query: 481 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 540
DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI
Sbjct: 481 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 540
Query: 541 IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT 600
IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT
Sbjct: 541 IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT 600
Query: 601 LQ---SISPKNFKVKMIMKTSVLLSWE--FPDNYNSP-TPYKIQYNGL 642
LQ S P++ K + T++L+SW P+ +N Y ++Y L
Sbjct: 601 LQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPL 648
Score = 116 bits (290), Expect = 2e-25
Identities = 159/717 (22%), Positives = 289/717 (40%), Gaps = 99/717 (13%)
Query: 50 ASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRT---------PR 100
A+ +C A+G+P P +TW K F ++ S G RI+ LR+
Sbjct: 152 ATMLCAASGNPDPEITWFKD--------FLPVDPSASNG---RIKQLRSGALQIESSEET 200
Query: 101 DENVYECVAQNSVG-EITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAAS 159
D+ YECVA NS G + A L V ++ P + P + + C A
Sbjct: 201 DQGKYECVATNSAGVRYSSPANLYV----RVRRVAPRFSILPMSHEIMPGGNVNITCVAV 256
Query: 160 GNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSS 219
G+P P + W + + P + G +E ++ D Y CVA +S GV +
Sbjct: 257 GSPMPYVKWMQGAEDLTPE------DDMPVGRNVLELTDVKDSANYTCVAMSSLGV-IEA 309
Query: 220 PANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPY----VKWMQGAED--LT 273
A + V+ AP PM E ++ IT + G+P P +++ ++D
Sbjct: 310 VAQITVKSLPKAPG---TPMVTE-NTATSITITWDS-GNPDPVSYYVIEYKSKSQDGPYQ 364
Query: 274 PEDDMPVGRNVLELTDVKDSANYTCVAMSSLGV---IEAVAQITVKSLP-KAPGTPMVTE 329
++D+ R + A++S+G E+V T + P AP
Sbjct: 365 IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARM 424
Query: 330 NTATSITITWDSGNPDPVS----------YYVIEYKSKSQDGP-YQIKEDITTTRYSIGG 378
+AT++ + W+ +PV YY +E + + + + + + TT +G
Sbjct: 425 LSATTMIVQWE----EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT---VGS 477
Query: 379 LSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV 438
L + Y + V A S+G GP S+ + +T + P P N++A S T++ + W P
Sbjct: 478 LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPR 536
Query: 439 EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 498
+ + I Y + + E +H G D + V L + Y R+ A + G G
Sbjct: 537 QES--IIKYELLFR-EGDH--GREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGA 591
Query: 499 LSDPIQVKTQQGVPGQP-MNLRAEARSETSITLSWSPPRQES--------IIKYELLFRE 549
+ ++ +T Q P P +++ + T+I +SW PP E+ ++Y L E
Sbjct: 592 FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSE 651
Query: 550 GDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT---LQSISP 606
+EV TT ++E L+ T+Y A + G G + V RT + S P
Sbjct: 652 DPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPP 711
Query: 607 KNFKVKMIMKTSVLLSWEFP---DNYNSPTPYKIQYNGLTLDVDGR------------TT 651
+ + + + T++ + W P + Y++ Y + + R
Sbjct: 712 RKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRME-GAEARGPPRIKDVMLADAQ 770
Query: 652 KKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIM 708
+ +IT+L+P T Y+ + G + + G+P+++ + +G ++
Sbjct: 771 EMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLL 827
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 1897 bits (4915), Expect = 0.0
Identities = 985/1291 (76%), Positives = 1046/1291 (81%), Gaps = 61/1291 (4%)
Query: 268 GAEDLTPED--DMPVGRNVLELTDVKDSANY--TCVAMSSLGVIEAVAQITVKS---LPK 320
G+ED P++ +P + L ++ Y T VA + +G + + V++ +P
Sbjct: 662 GSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPS 721
Query: 321 APGTPMVTEN-TATSITITWDSGNPD----PVSYYVIEY---KSKSQDGPYQIKE----- 367
AP + E AT+I + W S P + Y + Y + GP +IK+
Sbjct: 722 APPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLAD 781
Query: 368 ------DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQ 421
D I L P + Y I V+A G G S+ V T +VQ
Sbjct: 782 AQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQ 841
Query: 422 ARMLSATTMIVQWEEPV-EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480
+++ +WE P + GYR+ + E P+ + +D T + +
Sbjct: 842 --QTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRY--TASGVHK 897
Query: 481 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET-SITLSWSPP---- 535
TY R+ A + G G + + + G P L A + ++ L W PP
Sbjct: 898 GATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAE 957
Query: 536 RQESIIKYELLFREGD-----HGREVGRTFDP--TTSYVVEDLKPNTEYAFRLAARSPQG 588
R +I+KY + RE E+ +P + ++ LKP+T Y ++ A + +G
Sbjct: 958 RNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRG 1017
Query: 589 LGAFTPVVRQRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDV 646
G F+P VR RT +SPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDV
Sbjct: 1018 PGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDV 1077
Query: 647 DGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF 706
DGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF
Sbjct: 1078 DGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF 1137
Query: 707 IMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLR 766
IMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLR
Sbjct: 1138 IMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLR 1197
Query: 767 HSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTF 826
HSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTF
Sbjct: 1198 HSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTF 1257
Query: 827 AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS 886
AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS
Sbjct: 1258 AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS 1317
Query: 887 EPRTKCLLNNADLAPHHPKDPVEMRRINFQTP----------------GMLSHPPIPIAD 930
EPRTKCLLNNADLAPHHPKDPVEMRRINFQTP MLSHPPIPIAD
Sbjct: 1318 EPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPIPIAD 1377
Query: 931 MAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQP 990
MAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQP
Sbjct: 1378 MAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQP 1437
Query: 991 IEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKS 1050
IEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKS
Sbjct: 1438 IEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKS 1497
Query: 1051 RIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPD 1110
RIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPD
Sbjct: 1498 RIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPD 1557
Query: 1111 HGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDV 1170
HGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDV
Sbjct: 1558 HGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDV 1617
Query: 1171 YGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHV 1230
YGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHV
Sbjct: 1618 YGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHV 1677
Query: 1231 TGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYIN 1290
TGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYIN
Sbjct: 1678 TGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYIN 1737
Query: 1291 ASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE 1350
ASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE
Sbjct: 1738 ASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE 1797
Query: 1351 RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFI 1410
RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFI
Sbjct: 1798 RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFI 1857
Query: 1411 DFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRT 1470
DFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRT
Sbjct: 1858 DFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRT 1917
Query: 1471 QRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1501
QRPAMVQTEDEYQFCYQAALEYLGSFDHYAT
Sbjct: 1918 QRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1948
Score = 1214 bits (3140), Expect = 0.0
Identities = 614/661 (92%), Positives = 624/661 (94%), Gaps = 19/661 (2%)
Query: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP
Sbjct: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
Query: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA
Sbjct: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
Query: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS
Sbjct: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
Query: 181 NGRIKQLRS---------GALQIESSEETDQGKYECVATNSAGVRYSSPANLYVR----V 227
NGRIKQLRS GALQIESSEETDQGKYECVATNSAGVRYSSPANLYVR V
Sbjct: 181 NGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREV 240
Query: 228 RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL 287
RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL
Sbjct: 241 RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL 300
Query: 288 TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV 347
TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV
Sbjct: 301 TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV 360
Query: 348 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR 407
SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR
Sbjct: 361 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR 420
Query: 408 TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 467
TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV
Sbjct: 421 TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 480
Query: 468 DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 527
DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS
Sbjct: 481 DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 540
Query: 528 ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 587
ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ
Sbjct: 541 ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 600
Query: 588 GLGAFTPVVRQRTLQ---SISPKNFKVKMIMKTSVLLSWE--FPDNYNSP-TPYKIQYNG 641
GLGAFTPVVRQRTLQ S P++ K + T++L+SW P+ +N Y ++Y
Sbjct: 601 GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRP 660
Query: 642 L 642
L
Sbjct: 661 L 661
Score = 123 bits (308), Expect = 2e-27
Identities = 161/725 (22%), Positives = 291/725 (40%), Gaps = 93/725 (12%)
Query: 50 ASFVCQATGDPKPRVTWNK---------KGKKVNSQRFETIEFDESAGAVLRIQPLRTPR 100
A+ +C A+G+P P +TW K ++ R ET E GA L+I+
Sbjct: 152 ATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGA-LQIESSEET- 209
Query: 101 DENVYECVAQNSVG-EITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAAS 159
D+ YECVA NS G + A L V ++ P + P + + C A
Sbjct: 210 DQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAV 269
Query: 160 GNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSS 219
G+P P + W + + P + G +E ++ D Y CVA +S GV +
Sbjct: 270 GSPMPYVKWMQGAEDLTPE------DDMPVGRNVLELTDVKDSANYTCVAMSSLGV-IEA 322
Query: 220 PANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPY----VKWMQGAED--LT 273
A + V+ AP PM E ++ IT + G+P P +++ ++D
Sbjct: 323 VAQITVKSLPKAPG---TPMVTE-NTATSITITWDS-GNPDPVSYYVIEYKSKSQDGPYQ 377
Query: 274 PEDDMPVGRNVLELTDVKDSANYTCVAMSSLGV---IEAVAQITVKSLP-KAPGTPMVTE 329
++D+ R + A++S+G E+V T + P AP
Sbjct: 378 IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARM 437
Query: 330 NTATSITITWDSGNPDPVS----------YYVIEYKSKSQDGP-YQIKEDITTTRYSIGG 378
+AT++ + W+ +PV YY +E + + + + + + TT +G
Sbjct: 438 LSATTMIVQWE----EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT---VGS 490
Query: 379 LSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV 438
L + Y + V A S+G GP S+ + +T + P P N++A S T++ + W P
Sbjct: 491 LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPR 549
Query: 439 EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 498
+ + I Y + + E +H G D + V L + Y R+ A + G G
Sbjct: 550 QES--IIKYELLFR-EGDH--GREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGA 604
Query: 499 LSDPIQVKTQQGVPGQP-MNLRAEARSETSITLSWSPPRQES--------IIKYELLFRE 549
+ ++ +T Q P P +++ + T+I +SW PP E+ ++Y L E
Sbjct: 605 FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSE 664
Query: 550 GDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT---LQSISP 606
+EV TT ++E L+ T+Y A + G G + V RT + S P
Sbjct: 665 DPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPP 724
Query: 607 KNFKVKMIMKTSVLLSWEFP---DNYNSPTPYKIQY---------------NGLTLDVDG 648
+ + + + T++ + W P + Y++ Y + + D
Sbjct: 725 RKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQW 784
Query: 649 RTT-----KKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDA 703
T + +IT+L+P T Y+ + G + + G+P+++ +
Sbjct: 785 ETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTP 844
Query: 704 DGFIM 708
+G ++
Sbjct: 845 EGSLL 849
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 1541 bits (3990), Expect = 0.0
Identities = 796/1214 (65%), Positives = 938/1214 (77%), Gaps = 42/1214 (3%)
Query: 314 TVKSLPKAPGTPMVTENT-ATSITITWDSGNPDP----VSYYVIEY---KSKSQDGPYQI 365
T + +P P + E +TS+ ++W S P+ + Y + Y ++ G +
Sbjct: 706 TNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPML 765
Query: 366 KEDITTTRYS--IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQAR 423
K+ + I GL P + Y + V+A + G G S+ + T P PR V
Sbjct: 766 KDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLV-IN 823
Query: 424 MLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDET 483
T ++QW PV+ G ++GYR+ + + P+ + +D T + + +
Sbjct: 824 HTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT--DIHKGAS 881
Query: 484 YTVRVLAFTSVGDGP-----LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPP--- 535
Y R+ A VG G +S P +V T G P NL +E + TS+ LSW PP
Sbjct: 882 YVFRLSARNKVGFGEEMVKEISIPEEVPT-----GFPQNLHSEGTTSTSVQLSWQPPVLA 936
Query: 536 -RQESIIKYELLFREGDHGR-EVGRTFDPT-TSYVVEDLKPNTEYAFRLAARSPQGLGAF 592
R I KY LL+R+ + + + P T+ + LKP+T Y ++ A + +G G +
Sbjct: 937 ERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPY 996
Query: 593 TPVVRQRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDG 648
+P V+ RTL + KNF VK +MKTSVLLSWE P+NYNS P+KI Y+ + +VDG
Sbjct: 997 SPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDG 1056
Query: 649 RTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIM 708
R T+KLI +LKP Y+FVLTNRG+S GGLQ VTA TA ++L KP+ K + DG I
Sbjct: 1057 RATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMIT 1116
Query: 709 VYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHS 768
V LP+ + ++ Y+I++VPL+KSRG +F+ P SP++M+L+EL+++ISR +RRS+R+
Sbjct: 1117 VQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR-KRRSIRYG 1174
Query: 769 RQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FA 827
R++E+ +PYIAA F VLP F GD K YGGF N+ L+ G YV FVLAV++ +E +A
Sbjct: 1175 REVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYA 1233
Query: 828 ASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSE 887
SP+SDP + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK K R +S+
Sbjct: 1234 TSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRK----RAESD 1289
Query: 888 PRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLS 947
R + NN ++ HHP DPVE+RR+NFQTPGM SHPPIPI ++A+H ERLKAND+LK S
Sbjct: 1290 SRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFS 1349
Query: 948 QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDG 1007
QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV+L IEGI GSDY+NANY+DG
Sbjct: 1350 QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDG 1409
Query: 1008 YRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYG 1067
YR QNAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G
Sbjct: 1410 YRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHG 1469
Query: 1068 FIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRV 1127
+QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRV
Sbjct: 1470 LVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRV 1529
Query: 1128 KTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQT 1187
KTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQT
Sbjct: 1530 KTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQT 1589
Query: 1188 EDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHT 1247
EDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHT
Sbjct: 1590 EDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHT 1649
Query: 1248 SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQ 1307
SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQ
Sbjct: 1650 SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQ 1709
Query: 1308 GPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN 1367
GPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN
Sbjct: 1710 GPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN 1769
Query: 1368 MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG 1427
MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG
Sbjct: 1770 MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG 1829
Query: 1428 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ 1487
PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+
Sbjct: 1830 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1889
Query: 1488 AALEYLGSFDHYAT 1501
AALEYLGSFDHYAT
Sbjct: 1890 AALEYLGSFDHYAT 1903
Score = 889 bits (2297), Expect = 0.0
Identities = 444/669 (66%), Positives = 531/669 (79%), Gaps = 28/669 (4%)
Query: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
Query: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
Query: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS---------GALQIESSEE 199
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS GALQIE SEE
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
Query: 200 TDQGKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSILPMSHEIMPGGNVNITCVA 255
+DQGKYECVATNSAG RYS+PANLYVR VRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
Query: 256 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 315
VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319
Query: 316 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 375
K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS
Sbjct: 320 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379
Query: 376 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 435
+ GLSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 380 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439
Query: 436 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 495
EP EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+G
Sbjct: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
Query: 496 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 555
DGPLS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559
Query: 556 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ---SISPKNFKVK 612
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+Q S P++
Sbjct: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619
Query: 613 MIMKTSVLLSWEFP--DNYNS-PTPYKIQYNGL---------TLDVDGRTTKKLITHLKP 660
TS+L+SW+ P + N T Y I+Y + L + TTK L+ L+
Sbjct: 620 SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679
Query: 661 HTFYNFVLT 669
T Y +T
Sbjct: 680 WTEYRITVT 688
Score = 133 bits (335), Expect = 1e-30
Identities = 112/403 (27%), Positives = 181/403 (44%), Gaps = 36/403 (8%)
Query: 296 YTCVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITWDSGNPDPVSYYV 351
+ A S G+ + A+I+ +++ P P T ++TSI ++W + + +
Sbjct: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
Query: 352 IEYKSK------SQDGPYQIKE-DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESV 404
EY K D P++I TT+Y + L +EY I V+A +G GP S SV
Sbjct: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702
Query: 405 VTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRVYYT-MEPEHPVGN 461
+ RT E P+ PR V+ +++T++ V W PV + +G IRGY+V+Y ME P G
Sbjct: 703 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 762
Query: 462 WQKHNV--DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLR 519
+V D+ + L + +Y++ V A+T+ GDG S P V T VPG+P +
Sbjct: 763 PMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVI 822
Query: 520 AEARSETSITLSWSPPRQE--SIIKYELLFREGDHGREVGRTF-DPTTSYVVEDLKPNTE 576
+ T++ + W PP + Y L F D F + + D+
Sbjct: 823 NHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGAS 881
Query: 577 YAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKM----IMKTSVLLSWEFP---DNY 629
Y FRL+AR+ G G +V++ ++ P F + TSV LSW+ P +
Sbjct: 882 YVFRLSARNKVGFG--EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERN 939
Query: 630 NSPTPYKIQYNGLTLD-------VDGRTTKKLITHLKPHTFYN 665
T Y + Y + + + T +T LKP T Y+
Sbjct: 940 GIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYD 982
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 1541 bits (3989), Expect = 0.0
Identities = 798/1223 (65%), Positives = 939/1223 (76%), Gaps = 51/1223 (4%)
Query: 314 TVKSLPKAPGTPMVTENT-ATSITITWDSGNPDP----VSYYVIEY---KSKSQDGPYQI 365
T + +P P + E +TS+ ++W S P+ + Y + Y ++ G +
Sbjct: 706 TNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPML 765
Query: 366 KE-----------DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPA 414
K+ D T I GL P + Y + V+A + G G S+ + T P
Sbjct: 766 KDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 825
Query: 415 SAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT 474
PR V T ++QW PV+ G ++GYR+ + + P+ + +D T
Sbjct: 826 K-PRLV-INHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT 883
Query: 475 VGSLLEDETYTVRVLAFTSVGDGP-----LSDPIQVKTQQGVPGQPMNLRAEARSETSIT 529
+ + +Y R+ A VG G +S P +V T G P NL +E + TS+
Sbjct: 884 --DIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT-----GFPQNLHSEGTTSTSVQ 936
Query: 530 LSWSPP----RQESIIKYELLFREGDHGR-EVGRTFDPT-TSYVVEDLKPNTEYAFRLAA 583
LSW PP R I KY LL+R+ + + + P T+ + LKP+T Y ++ A
Sbjct: 937 LSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRA 996
Query: 584 RSPQGLGAFTPVVRQRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG 641
+ +G G ++P V+ RTL + KNF VK +MKTSVLLSWE P+NYNS P+KI Y+
Sbjct: 997 HTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDD 1056
Query: 642 --LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP 699
+ +VDGR T+KLI +LKP Y+FVLTNRG+S GGLQ VTA TA ++L KP+
Sbjct: 1057 GKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIG 1116
Query: 700 KPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISR 759
K + DG I V LP+ + ++ Y+I++VPL+KSRG +F+ P SP++M+L+EL+++ISR
Sbjct: 1117 KTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR 1175
Query: 760 LQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVL 819
+RRS+R+ R++E+ +PYIAA F VLP F GD K YGGF N+ L+ G YV FVLAV+
Sbjct: 1176 -KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM 1233
Query: 820 QKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK 878
+ +E +A SP+SDP + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK K
Sbjct: 1234 EHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRK 1293
Query: 879 PDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERL 938
R +S+ R + NN ++ HHP DPVE+RR+NFQTPGM SHPPIPI ++A+H ERL
Sbjct: 1294 ----RAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERL 1349
Query: 939 KANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSD 998
KAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV+L IEGI GSD
Sbjct: 1350 KANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSD 1409
Query: 999 YINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYW 1058
Y+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYW
Sbjct: 1410 YVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYW 1469
Query: 1059 PNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPT 1118
P+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PT
Sbjct: 1470 PSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPT 1529
Query: 1119 PFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMR 1178
PFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR
Sbjct: 1530 PFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMR 1589
Query: 1179 SQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFK 1238
+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFK
Sbjct: 1590 AQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFK 1649
Query: 1239 RLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1298
RLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR
Sbjct: 1650 RLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1709
Query: 1299 QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1358
QQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYF
Sbjct: 1710 QQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1769
Query: 1359 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1418
VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK
Sbjct: 1770 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1829
Query: 1419 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1478
TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT
Sbjct: 1830 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1889
Query: 1479 EDEYQFCYQAALEYLGSFDHYAT 1501
ED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1890 EDQYQFSYRAALEYLGSFDHYAT 1912
Score = 889 bits (2297), Expect = 0.0
Identities = 444/669 (66%), Positives = 531/669 (79%), Gaps = 28/669 (4%)
Query: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
Query: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
Query: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS---------GALQIESSEE 199
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS GALQIE SEE
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
Query: 200 TDQGKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSILPMSHEIMPGGNVNITCVA 255
+DQGKYECVATNSAG RYS+PANLYVR VRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
Query: 256 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 315
VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319
Query: 316 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 375
K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS
Sbjct: 320 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379
Query: 376 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 435
+ GLSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 380 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439
Query: 436 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 495
EP EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+G
Sbjct: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499
Query: 496 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 555
DGPLS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559
Query: 556 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ---SISPKNFKVK 612
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+Q S P++
Sbjct: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619
Query: 613 MIMKTSVLLSWEFP--DNYNS-PTPYKIQYNGL---------TLDVDGRTTKKLITHLKP 660
TS+L+SW+ P + N T Y I+Y + L + TTK L+ L+
Sbjct: 620 SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679
Query: 661 HTFYNFVLT 669
T Y +T
Sbjct: 680 WTEYRITVT 688
Score = 129 bits (325), Expect = 2e-29
Identities = 113/412 (27%), Positives = 182/412 (44%), Gaps = 45/412 (10%)
Query: 296 YTCVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITWDSGNPDPVSYYV 351
+ A S G+ + A+I+ +++ P P T ++TSI ++W + + +
Sbjct: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
Query: 352 IEYKSK------SQDGPYQIKE-DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESV 404
EY K D P++I TT+Y + L +EY I V+A +G GP S SV
Sbjct: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702
Query: 405 VTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRVYYT-MEPEHPVGN 461
+ RT E P+ PR V+ +++T++ V W PV + +G IRGY+V+Y ME P G
Sbjct: 703 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 762
Query: 462 WQKHNV---------DDSLL--TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG 510
+V DD+ + L + +Y++ V A+T+ GDG S P V T
Sbjct: 763 PMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA 822
Query: 511 VPGQPMNLRAEARSETSITLSWSPPRQE--SIIKYELLFREGDHGREVGRTF-DPTTSYV 567
VPG+P + + T++ + W PP + Y L F D F + +
Sbjct: 823 VPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFT 881
Query: 568 VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKM----IMKTSVLLSW 623
D+ Y FRL+AR+ G G +V++ ++ P F + TSV LSW
Sbjct: 882 ATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSW 939
Query: 624 EFP---DNYNSPTPYKIQYNGLTLD-------VDGRTTKKLITHLKPHTFYN 665
+ P + T Y + Y + + + T +T LKP T Y+
Sbjct: 940 QPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYD 991
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 1541 bits (3989), Expect = 0.0
Identities = 798/1223 (65%), Positives = 939/1223 (76%), Gaps = 51/1223 (4%)
Query: 314 TVKSLPKAPGTPMVTENT-ATSITITWDSGNPDP----VSYYVIEY---KSKSQDGPYQI 365
T + +P P + E +TS+ ++W S P+ + Y + Y ++ G +
Sbjct: 693 TNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPML 752
Query: 366 KE-----------DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPA 414
K+ D T I GL P + Y + V+A + G G S+ + T P
Sbjct: 753 KDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 812
Query: 415 SAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT 474
PR V T ++QW PV+ G ++GYR+ + + P+ + +D T
Sbjct: 813 K-PRLV-INHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT 870
Query: 475 VGSLLEDETYTVRVLAFTSVGDGP-----LSDPIQVKTQQGVPGQPMNLRAEARSETSIT 529
+ + +Y R+ A VG G +S P +V T G P NL +E + TS+
Sbjct: 871 --DIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT-----GFPQNLHSEGTTSTSVQ 923
Query: 530 LSWSPP----RQESIIKYELLFREGDHGR-EVGRTFDPT-TSYVVEDLKPNTEYAFRLAA 583
LSW PP R I KY LL+R+ + + + P T+ + LKP+T Y ++ A
Sbjct: 924 LSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRA 983
Query: 584 RSPQGLGAFTPVVRQRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG 641
+ +G G ++P V+ RTL + KNF VK +MKTSVLLSWE P+NYNS P+KI Y+
Sbjct: 984 HTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDD 1043
Query: 642 --LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP 699
+ +VDGR T+KLI +LKP Y+FVLTNRG+S GGLQ VTA TA ++L KP+
Sbjct: 1044 GKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIG 1103
Query: 700 KPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISR 759
K + DG I V LP+ + ++ Y+I++VPL+KSRG +F+ P SP++M+L+EL+++ISR
Sbjct: 1104 KTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR 1162
Query: 760 LQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVL 819
+RRS+R+ R++E+ +PYIAA F VLP F GD K YGGF N+ L+ G YV FVLAV+
Sbjct: 1163 -KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM 1220
Query: 820 QKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK 878
+ +E +A SP+SDP + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK K
Sbjct: 1221 EHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRK 1280
Query: 879 PDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERL 938
R +S+ R + NN ++ HHP DPVE+RR+NFQTPGM SHPPIPI ++A+H ERL
Sbjct: 1281 ----RAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERL 1336
Query: 939 KANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSD 998
KAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV+L IEGI GSD
Sbjct: 1337 KANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSD 1396
Query: 999 YINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYW 1058
Y+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYW
Sbjct: 1397 YVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYW 1456
Query: 1059 PNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPT 1118
P+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PT
Sbjct: 1457 PSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPT 1516
Query: 1119 PFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMR 1178
PFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR
Sbjct: 1517 PFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMR 1576
Query: 1179 SQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFK 1238
+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFK
Sbjct: 1577 AQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFK 1636
Query: 1239 RLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1298
RLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR
Sbjct: 1637 RLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1696
Query: 1299 QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1358
QQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYF
Sbjct: 1697 QQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1756
Query: 1359 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1418
VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK
Sbjct: 1757 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1816
Query: 1419 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1478
TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT
Sbjct: 1817 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1876
Query: 1479 EDEYQFCYQAALEYLGSFDHYAT 1501
ED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1877 EDQYQFSYRAALEYLGSFDHYAT 1899
Score = 902 bits (2332), Expect = 0.0
Identities = 444/656 (67%), Positives = 531/656 (80%), Gaps = 15/656 (2%)
Query: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
Query: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
Query: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECV 208
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRSGALQIE SEE+DQGKYECV
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECV 199
Query: 209 ATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQG 268
ATNSAG RYS+PANLYVRVRRV PRFSI P +HEIMPGG+VNITCVAVGSPMPYVKWM G
Sbjct: 200 ATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLG 259
Query: 269 AEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVT 328
AEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITVK+LPK PGTP+VT
Sbjct: 260 AEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVT 319
Query: 329 ENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIW 388
E+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS+ GLSP S+YE
Sbjct: 320 ESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFR 379
Query: 389 VSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYR 448
V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+EP EPNG I+GYR
Sbjct: 380 VVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYR 439
Query: 449 VYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQ 508
VYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+GDGPLS IQV TQ
Sbjct: 440 VYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQ 499
Query: 509 QGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVV 568
GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E T +P TSY +
Sbjct: 500 TGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRL 559
Query: 569 EDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ---SISPKNFKVKMIMKTSVLLSWEF 625
+ LKPN+ Y FRLAARSPQGLGA T + RT+Q S P++ TS+L+SW+
Sbjct: 560 QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQP 619
Query: 626 P--DNYNS-PTPYKIQYNGL---------TLDVDGRTTKKLITHLKPHTFYNFVLT 669
P + N T Y I+Y + L + TTK L+ L+ T Y +T
Sbjct: 620 PPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVT 675
Score = 129 bits (325), Expect = 2e-29
Identities = 113/412 (27%), Positives = 182/412 (44%), Gaps = 45/412 (10%)
Query: 296 YTCVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITWDSGNPDPVSYYV 351
+ A S G+ + A+I+ +++ P P T ++TSI ++W + + +
Sbjct: 570 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 629
Query: 352 IEYKSK------SQDGPYQIKE-DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESV 404
EY K D P++I TT+Y + L +EY I V+A +G GP S SV
Sbjct: 630 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 689
Query: 405 VTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRVYYT-MEPEHPVGN 461
+ RT E P+ PR V+ +++T++ V W PV + +G IRGY+V+Y ME P G
Sbjct: 690 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 749
Query: 462 WQKHNV---------DDSLL--TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG 510
+V DD+ + L + +Y++ V A+T+ GDG S P V T
Sbjct: 750 PMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA 809
Query: 511 VPGQPMNLRAEARSETSITLSWSPPRQE--SIIKYELLFREGDHGREVGRTF-DPTTSYV 567
VPG+P + + T++ + W PP + Y L F D F + +
Sbjct: 810 VPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFT 868
Query: 568 VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKM----IMKTSVLLSW 623
D+ Y FRL+AR+ G G +V++ ++ P F + TSV LSW
Sbjct: 869 ATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSW 926
Query: 624 EFP---DNYNSPTPYKIQYNGLTLD-------VDGRTTKKLITHLKPHTFYN 665
+ P + T Y + Y + + + T +T LKP T Y+
Sbjct: 927 QPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYD 978
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 1407 bits (3642), Expect = 0.0
Identities = 736/1149 (64%), Positives = 861/1149 (74%), Gaps = 33/1149 (2%)
Query: 367 EDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLS 426
ED TT I GL+P + Y + V+A + G G S+ + T P + ++
Sbjct: 778 EDYETT---ISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMN 834
Query: 427 ATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTV 486
T ++QW P E G + GYR+ Y E N DD T G L + TY
Sbjct: 835 --TALLQWHPPKELPGELLGYRLQYCRADEARP-NTIDFGKDDQHFTVTG-LHKGTTYIF 890
Query: 487 RVLAFTSVGDGPLSDPIQVKTQQGVP-GQPMNLRAEARSETSITLSWSPP----RQESII 541
R+ A G G + +++T + +P G P NL + ++ L+W PP R II
Sbjct: 891 RLAAKNRAGLGEEFEK-EIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRII 949
Query: 542 KYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTL 601
Y ++FR+ + +E+ + T + + LKP+T Y ++ A + +G G +P ++ RT+
Sbjct: 950 SYTVVFRDINSQQEL-QNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTM 1008
Query: 602 --QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLK 659
+ + KNF+V MKTSVLLSWE PD+Y S P+KI YNG +++VDG + +KLI L+
Sbjct: 1009 PVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQ 1068
Query: 660 PHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVP 719
P+T Y+FVL NRGSS GGLQ V+ TA +LL KP A DG + +P Q P
Sbjct: 1069 PNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSL 1128
Query: 720 VQSYFIVMVPLRKSRGGQFLTPLGS-PEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYI 778
V+ ++IV+VP+ + GG LTP S PE+++L+EL++ I + R RQ E +PY+
Sbjct: 1129 VRWFYIVVVPIDRV-GGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYV 1187
Query: 779 AARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQK--SEPTFAASPFSDPFQ 836
AA+ VLP TF GD+K Y GF NR L P Y FVLA L++ + +A+SP+SD
Sbjct: 1188 AAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIV 1247
Query: 837 LDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK----PDSKRKDSEPRTKC 892
+ Q + E ++WV GPVLAV+ II IVIAILL+K K P SK + S
Sbjct: 1248 VQVTPAQQQEEPE--MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDS 1305
Query: 893 LLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYES 952
LL H DPVEMRR+N+QTPGM HPPIPI D+A++ ERLKAND LK SQEYES
Sbjct: 1306 LLA-------HSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYES 1358
Query: 953 IDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQN 1012
IDPGQQFTWE+SNLEVNKPKNRYANVIAYDHSRVIL I+G+ GSDYINANY+DGYR QN
Sbjct: 1359 IDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQN 1418
Query: 1013 AYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVT 1072
AYIATQGPLPET GDFWRMVWEQR+AT+VMMTRLEEKSR+KCDQYWP RGTET G IQVT
Sbjct: 1419 AYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVT 1478
Query: 1073 LLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNP 1132
LLDT+ELAT+ VRTF+LHK+GSSEKRE+RQFQF AWPDHGVPEYPTP LAFLRRVK CNP
Sbjct: 1479 LLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNP 1538
Query: 1133 PDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYS 1192
DAGP+VVHCSAGVGRTGCFIVIDAMLER+K EKTVD+YGHVT MRSQRNYMVQTEDQY
Sbjct: 1539 LDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYV 1598
Query: 1193 FIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFIS 1252
FIHEALLEA CG+TEVPAR+LYA+IQKL QV PGE VT MELEFK LA+SKAHTSRFIS
Sbjct: 1599 FIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFIS 1658
Query: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312
ANLPCNKFKNRLVNIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE
Sbjct: 1659 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1718
Query: 1313 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYI 1372
+TEDFWRMLWE+NSTI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYI
Sbjct: 1719 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYI 1778
Query: 1373 LREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVH 1432
LREFKVTDARDGQSRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VH
Sbjct: 1779 LREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVH 1838
Query: 1433 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 1492
CSAGVGRTGVFITLSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTED+YQ CY+AALEY
Sbjct: 1839 CSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY 1898
Query: 1493 LGSFDHYAT 1501
LGSFDHYAT
Sbjct: 1899 LGSFDHYAT 1907
Score = 844 bits (2180), Expect = 0.0
Identities = 440/711 (61%), Positives = 528/711 (74%), Gaps = 23/711 (3%)
Query: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
MAP PG V L+++ LV G + P FIK P+DQ G+SGGVASFVCQATG+P
Sbjct: 1 MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60
Query: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
KPR+TW KKGKKV+SQRFE IEFD+ AG+VLRIQPLR RDE +YEC A NS+GEI A
Sbjct: 61 KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120
Query: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
KL+VL E+QLP GFP+IDMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVDP+ S
Sbjct: 121 KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180
Query: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS 240
NGRIKQLRSGALQIESSEE+DQGKYECVATNSAG RYS+PANLYVRVRRVAPRFSI P S
Sbjct: 181 NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS 240
Query: 241 HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA 300
E+MPGG+VN+TCVAVG+PMPYVKWM GAE+LT ED+MPVGRNVLEL++V SANYTCVA
Sbjct: 241 QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA 300
Query: 301 MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD 360
+SSLG+IEA AQ+TVK+LPK P +VTE TATS+T+TWDSGN +PV+YY I+Y++ +
Sbjct: 301 ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE 360
Query: 361 GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420
GP+Q + + TTRYSIGGLSP SEY V AVNSIG+GPPSE+V RTGEQAP+S PR V
Sbjct: 361 GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420
Query: 421 QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480
QARMLSA+TM+VQWE P EPNGL+RGYRVYYT + P W KHN D LLTTVGSLL
Sbjct: 421 QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP 480
Query: 481 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 540
TY++RVLAFT+VGDGP S IQVKTQQGVP QP + +AE S+T I LSW P QE I
Sbjct: 481 GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI 540
Query: 541 IKYELLF-REGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQR 599
I YEL++ D ++ TFDPT+SY +EDLKP+T Y F+LAARS G+G FTP + R
Sbjct: 541 IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR 600
Query: 600 TLQ---SISPKNFKVKMIMKTSVLLSWEFP--DNYNSP-TPYKIQYNGLTLDVDGRTTKK 653
T Q S P+ + T+V +SW P D+ N T Y + Y + + GR
Sbjct: 601 TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD 660
Query: 654 LITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNL-LNGKPSVAPKPDA 703
I+ + H+ ++ V GL++ WT + + + V P P++
Sbjct: 661 GIS--REHSSWDLV---------GLEK----WTEYRVWVRAHTDVGPGPES 696
Score = 138 bits (347), Expect = 5e-32
Identities = 123/431 (28%), Positives = 190/431 (44%), Gaps = 47/431 (10%)
Query: 287 LTDVKDSANYT--CVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITW- 339
L D+K Y A S +GV I ++ P P M +T++ ++W
Sbjct: 569 LEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWV 628
Query: 340 ----DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITT--TRYSIGGLSPNSEYEIWVSAVN 393
DS N Y V +D + + I+ + + + GL +EY +WV A
Sbjct: 629 PPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT 688
Query: 394 SIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRV-Y 450
+G GP S V+ RT E P+ PR V+ L++T + V W+ PV + +G IRGY+V Y
Sbjct: 689 DVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTY 748
Query: 451 YTMEPEHPVG------------NWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 498
+E P G W+ +D TT+ L + TY+V V A+T+ GDG
Sbjct: 749 VRLENGEPRGLPIIQDVMLAEAQWRPEESED-YETTISGLTPETTYSVTVAAYTTKGDGA 807
Query: 499 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQ--ESIIKYELLFREGDHGREV 556
S P V T VPG+P + + T++ L W PP++ ++ Y L + D R
Sbjct: 808 RSKPKIVTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEARPN 866
Query: 557 GRTFDPTTS-YVVEDLKPNTEYAFRLAARSPQGLG-AFTPVVR-QRTLQSISPKNFKVKM 613
F + V L T Y FRLAA++ GLG F +R L S P+N V
Sbjct: 867 TIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTG 926
Query: 614 IMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGR--------TTKKLITHLKPHTFYN 665
+ ++ L+W+ P I Y + D++ + T+ +T LKP T Y+
Sbjct: 927 LTTSTTELAWD-PPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYD 985
Query: 666 FVL---TNRGS 673
+ T++GS
Sbjct: 986 IKVRAWTSKGS 996
Score = 51.6 bits (122), Expect = 6e-06
Identities = 54/210 (25%), Positives = 89/210 (42%), Gaps = 21/210 (10%)
Query: 314 TVKSLPKA-PGTPMVTENTATSITITWD-----SGNPDPVSYYVIEYKSKSQDGPYQIKE 367
T + LP P VT T ++ + WD N +SY V+ SQ +++
Sbjct: 910 TPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQ---ELQN 966
Query: 368 DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSA 427
T TR+++ GL P++ Y+I V A S G GP S S+ +RT A +N +
Sbjct: 967 ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFA-KNFRVAAAMK 1025
Query: 428 TTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVR 487
T++++ WE P Y + P + N Q VD + + + L+ T
Sbjct: 1026 TSVLLSWEVPDS----------YKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSF 1075
Query: 488 VLAFTSVGDGPLSDPIQVKTQQG-VPGQPM 516
VL G L + ++T +P +P+
Sbjct: 1076 VLMNRGSSAGGLQHLVSIRTAPDLLPHKPL 1105
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 1405 bits (3638), Expect = 0.0
Identities = 732/1141 (64%), Positives = 858/1141 (75%), Gaps = 30/1141 (2%)
Query: 375 SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQW 434
+I GL+P + Y + V+A + G G S+ + T P + ++ T ++QW
Sbjct: 774 TISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMN--TALLQW 831
Query: 435 EEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSV 494
P E G + GYR+ Y E N DD T G L + TY R+ A
Sbjct: 832 HPPKELPGELLGYRLQYCRADEARP-NTIDFGKDDQHFTVTG-LHKGTTYIFRLAAKNRA 889
Query: 495 GDGPLSDPIQVKTQQGVP-GQPMNLRAEARSETSITLSWSPP----RQESIIKYELLFRE 549
G G + +++T + +P G P NL + ++ L+W PP R II Y ++FR+
Sbjct: 890 GLGEEFEK-EIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD 948
Query: 550 GDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTL--QSISPK 607
+ +E+ + T + + LKP+T Y ++ A + +G G +P ++ RT+ + + K
Sbjct: 949 INSQQEL-QNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAK 1007
Query: 608 NFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFV 667
NF+V MKTSVLLSWE PD+Y S P+KI YNG +++VDG + +KLI L+P+T Y+FV
Sbjct: 1008 NFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFV 1067
Query: 668 LTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVM 727
L NRGSS GGLQ V+ TA +LL KP A DG + +P Q P V+ ++IV+
Sbjct: 1068 LMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVV 1127
Query: 728 VPLRKSRGGQFLTPLGS-PEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLP 786
VP+ + GG LTP S PE+++L+EL++ I + R RQ E +PY+AA+ VLP
Sbjct: 1128 VPIDRV-GGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLP 1186
Query: 787 PTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQK--SEPTFAASPFSDPFQLDNPDPQP 844
TF GD+K Y GF NR L P Y FVLA L++ + +A+SP+SD + Q
Sbjct: 1187 ETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQ 1246
Query: 845 IVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK----PDSKRKDSEPRTKCLLNNADLA 900
+ E ++WV GPVLAV+ II IVIAILL+K K P SK + S LL
Sbjct: 1247 QEEPE--MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLA----- 1299
Query: 901 PHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFT 960
H DPVEMRR+N+QTPGM HPPIPI D+A++ ERLKAND LK SQEYESIDPGQQFT
Sbjct: 1300 --HSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFT 1357
Query: 961 WEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGP 1020
WE+SNLEVNKPKNRYANVIAYDHSRVIL I+G+ GSDYINANY+DGYR QNAYIATQGP
Sbjct: 1358 WENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGP 1417
Query: 1021 LPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELA 1080
LPET GDFWRMVWEQR+AT+VMMTRLEEKSR+KCDQYWP RGTET G IQVTLLDT+ELA
Sbjct: 1418 LPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELA 1477
Query: 1081 TFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVV 1140
T+ VRTF+LHK+GSSEKRE+RQFQF AWPDHGVPEYPTP LAFLRRVK CNP DAGP+VV
Sbjct: 1478 TYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVV 1537
Query: 1141 HCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE 1200
HCSAGVGRTGCFIVIDAMLER+K EKTVD+YGHVT MRSQRNYMVQTEDQY FIHEALLE
Sbjct: 1538 HCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1597
Query: 1201 AVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKF 1260
A CG+TEVPAR+LYA+IQKL QV PGE VT MELEFK LA+SKAHTSRFISANLPCNKF
Sbjct: 1598 AATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKF 1657
Query: 1261 KNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRM 1320
KNRLVNIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRM
Sbjct: 1658 KNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRM 1717
Query: 1321 LWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD 1380
LWE+NSTI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD
Sbjct: 1718 LWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD 1777
Query: 1381 ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRT 1440
ARDGQSRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRT
Sbjct: 1778 ARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRT 1837
Query: 1441 GVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA 1500
GVFITLSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTED+YQ CY+AALEYLGSFDHYA
Sbjct: 1838 GVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA 1897
Query: 1501 T 1501
T
Sbjct: 1898 T 1898
Score = 844 bits (2180), Expect = 0.0
Identities = 440/711 (61%), Positives = 528/711 (74%), Gaps = 23/711 (3%)
Query: 1 MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
MAP PG V L+++ LV G + P FIK P+DQ G+SGGVASFVCQATG+P
Sbjct: 1 MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60
Query: 61 KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
KPR+TW KKGKKV+SQRFE IEFD+ AG+VLRIQPLR RDE +YEC A NS+GEI A
Sbjct: 61 KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120
Query: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
KL+VL E+QLP GFP+IDMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVDP+ S
Sbjct: 121 KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180
Query: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS 240
NGRIKQLRSGALQIESSEE+DQGKYECVATNSAG RYS+PANLYVRVRRVAPRFSI P S
Sbjct: 181 NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS 240
Query: 241 HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA 300
E+MPGG+VN+TCVAVG+PMPYVKWM GAE+LT ED+MPVGRNVLEL++V SANYTCVA
Sbjct: 241 QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA 300
Query: 301 MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD 360
+SSLG+IEA AQ+TVK+LPK P +VTE TATS+T+TWDSGN +PV+YY I+Y++ +
Sbjct: 301 ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE 360
Query: 361 GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420
GP+Q + + TTRYSIGGLSP SEY V AVNSIG+GPPSE+V RTGEQAP+S PR V
Sbjct: 361 GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420
Query: 421 QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480
QARMLSA+TM+VQWE P EPNGL+RGYRVYYT + P W KHN D LLTTVGSLL
Sbjct: 421 QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP 480
Query: 481 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 540
TY++RVLAFT+VGDGP S IQVKTQQGVP QP + +AE S+T I LSW P QE I
Sbjct: 481 GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI 540
Query: 541 IKYELLF-REGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQR 599
I YEL++ D ++ TFDPT+SY +EDLKP+T Y F+LAARS G+G FTP + R
Sbjct: 541 IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR 600
Query: 600 TLQ---SISPKNFKVKMIMKTSVLLSWEFP--DNYNSP-TPYKIQYNGLTLDVDGRTTKK 653
T Q S P+ + T+V +SW P D+ N T Y + Y + + GR
Sbjct: 601 TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD 660
Query: 654 LITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNL-LNGKPSVAPKPDA 703
I+ + H+ ++ V GL++ WT + + + V P P++
Sbjct: 661 GIS--REHSSWDLV---------GLEK----WTEYRVWVRAHTDVGPGPES 696
Score = 137 bits (346), Expect = 6e-32
Identities = 122/421 (28%), Positives = 190/421 (45%), Gaps = 36/421 (8%)
Query: 287 LTDVKDSANYT--CVAMSSLGVIEAVAQITVKSLPKAPGTP----MVTENTATSITITW- 339
L D+K Y A S +GV I ++ P P M +T++ ++W
Sbjct: 569 LEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWV 628
Query: 340 ----DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITT--TRYSIGGLSPNSEYEIWVSAVN 393
DS N Y V +D + + I+ + + + GL +EY +WV A
Sbjct: 629 PPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT 688
Query: 394 SIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV--EPNGLIRGYRV-Y 450
+G GP S V+ RT E P+ PR V+ L++T + V W+ PV + +G IRGY+V Y
Sbjct: 689 DVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTY 748
Query: 451 YTMEPEHPVG--NWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQ 508
+E P G Q + ++ TT+ L + TY+V V A+T+ GDG S P V T
Sbjct: 749 VRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTT 808
Query: 509 QGVPGQPMNLRAEARSETSITLSWSPPRQ--ESIIKYELLFREGDHGREVGRTFDPTTS- 565
VPG+P + + T++ L W PP++ ++ Y L + D R F
Sbjct: 809 GAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQH 867
Query: 566 YVVEDLKPNTEYAFRLAARSPQGLG-AFTPVVR-QRTLQSISPKNFKVKMIMKTSVLLSW 623
+ V L T Y FRLAA++ GLG F +R L S P+N V + ++ L+W
Sbjct: 868 FTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAW 927
Query: 624 EFPDNYNSPTPYKIQYNGLTLDVDGR--------TTKKLITHLKPHTFYNFVL---TNRG 672
+ P I Y + D++ + T+ +T LKP T Y+ + T++G
Sbjct: 928 D-PPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKG 986
Query: 673 S 673
S
Sbjct: 987 S 987
Score = 51.6 bits (122), Expect = 6e-06
Identities = 54/210 (25%), Positives = 89/210 (42%), Gaps = 21/210 (10%)
Query: 314 TVKSLPKA-PGTPMVTENTATSITITWD-----SGNPDPVSYYVIEYKSKSQDGPYQIKE 367
T + LP P VT T ++ + WD N +SY V+ SQ +++
Sbjct: 901 TPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQ---ELQN 957
Query: 368 DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSA 427
T TR+++ GL P++ Y+I V A S G GP S S+ +RT A +N +
Sbjct: 958 ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFA-KNFRVAAAMK 1016
Query: 428 TTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVR 487
T++++ WE P Y + P + N Q VD + + + L+ T
Sbjct: 1017 TSVLLSWEVPDS----------YKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSF 1066
Query: 488 VLAFTSVGDGPLSDPIQVKTQQG-VPGQPM 516
VL G L + ++T +P +P+
Sbjct: 1067 VLMNRGSSAGGLQHLVSIRTAPDLLPHKPL 1096
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 592 bits (1525), Expect = e-168
Identities = 312/682 (45%), Positives = 426/682 (62%), Gaps = 22/682 (3%)
Query: 825 TFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRK 884
TF S SD D D PI+ ++ + +L +VFII ++ + K K
Sbjct: 134 TFPPSGNSD--SKDRRDETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHS 187
Query: 885 DSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGM-LSHPPIPIADMAEHTERLKANDS 943
+S L+N P+ + R +P +PP+P+ + E R A+D+
Sbjct: 188 NS-----FRLSNGRTEDVEPQSVPLLAR----SPSTNRKYPPLPVDKLEEEINRRMADDN 238
Query: 944 LKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINA 1002
+E+ ++ Q T E ++ E NK KNRY N++ YDHSRV L P+EG+ SDYINA
Sbjct: 239 KLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINA 298
Query: 1003 NYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG 1062
++++GY+ +N +IA QGP ET DFWRM+WEQ +ATIVM+T L+E+ KC QYWP++G
Sbjct: 299 SFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQG 358
Query: 1063 TETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKRE----VRQFQFTAWPDHGVPEYPT 1118
TYG I+V++ D L + VR F + + G R+ + QF FT+WPD GVP P
Sbjct: 359 CWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPI 418
Query: 1119 PFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMR 1178
L FL++VK CNP AG IVVHCSAGVGRTG F+VIDAML+ + E+ VDVYG V+ +R
Sbjct: 419 GMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIR 478
Query: 1179 SQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFK 1238
+QR MVQT+ QY FI++ALLE G+TE+ SL ++QK+ PG G+E EFK
Sbjct: 479 AQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFK 538
Query: 1239 RLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1298
+L + K + + NLP N KNR++ I+PYE RV + RG E +DY+NASFIDGYR
Sbjct: 539 KLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYR 598
Query: 1299 QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1358
Q+ +YIA+QGPL T EDFWRM+WE S +VMLT+L E G+EKC QYWP++ Y
Sbjct: 599 QKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDI 658
Query: 1359 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1418
V+ E Y +R+ VT+ R+ +SR +RQF F WPE G+P G+G I I V K
Sbjct: 659 TVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQK 718
Query: 1419 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1478
++Q G + PI+VHCSAG GRTG F LS VLER++ EG++D+FQTVK LR QRP MVQT
Sbjct: 719 QQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQT 777
Query: 1479 EDEYQFCYQAALEYLGSFDHYA 1500
++Y+FCY+ EY+ +F YA
Sbjct: 778 LEQYEFCYKVVQEYIDAFSDYA 799
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 589 bits (1518), Expect = e-168
Identities = 306/666 (45%), Positives = 420/666 (63%), Gaps = 20/666 (3%)
Query: 841 DPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLA 900
D PI+ ++ + +L +VFII ++ + K K +S L+N
Sbjct: 139 DETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNS-----FRLSNGRTE 189
Query: 901 PHHPKDPVEMRRINFQTPGM-LSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-Q 958
P+ + R +P +PP+P+ + E R A+D+ +E+ ++ Q
Sbjct: 190 DVEPQSVPLLAR----SPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQ 245
Query: 959 FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQ 1018
T E ++ E NK KNRY N++ YDHSRV L P+EG+ SDYINA++++GY+ +N +IA Q
Sbjct: 246 ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQ 305
Query: 1019 GPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIE 1078
GP ET DFWRM+WEQ +ATIVM+T L+E+ KC QYWP++G TYG I+V++ D
Sbjct: 306 GPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTV 365
Query: 1079 LATFCVRTFSLHKNGSSEKRE----VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1134
L + VR F + + G R+ + QF FT+WPD GVP P L FL++VK CNP
Sbjct: 366 LVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQY 425
Query: 1135 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1194
AG IVVHCSAGVGRTG F+VIDAML+ + E+ VDVYG V+ +R+QR MVQT+ QY FI
Sbjct: 426 AGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFI 485
Query: 1195 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISAN 1254
++ALLE G+TE+ SL ++QK+ PG G+E EFK+L + K + + N
Sbjct: 486 YQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGN 545
Query: 1255 LPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETT 1314
LP N KNR++ I+PYE RV + RG E +DY+NASFIDGYRQ+ +YIA+QGPL T
Sbjct: 546 LPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTI 605
Query: 1315 EDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1374
EDFWRM+WE S +VMLT+L E G+EKC QYWP++ Y V+ E Y +R
Sbjct: 606 EDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVR 665
Query: 1375 EFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCS 1434
+ VT+ R+ +SR +RQF F WPE G+P G+G I I V K ++Q G + PI+VHCS
Sbjct: 666 DLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCS 724
Query: 1435 AGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG 1494
AG GRTG F LS VLER++ EG++D+FQTVK LR QRP MVQT ++Y+FCY+ EY+
Sbjct: 725 AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
Query: 1495 SFDHYA 1500
+F YA
Sbjct: 785 AFSDYA 790
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 589 bits (1518), Expect = e-168
Identities = 306/666 (45%), Positives = 420/666 (63%), Gaps = 20/666 (3%)
Query: 841 DPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLA 900
D PI+ ++ + +L +VFII ++ + K K +S L+N
Sbjct: 139 DETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNS-----FRLSNGRTE 189
Query: 901 PHHPKDPVEMRRINFQTPGM-LSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-Q 958
P+ + R +P +PP+P+ + E R A+D+ +E+ ++ Q
Sbjct: 190 DVEPQSVPLLAR----SPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQ 245
Query: 959 FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQ 1018
T E ++ E NK KNRY N++ YDHSRV L P+EG+ SDYINA++++GY+ +N +IA Q
Sbjct: 246 ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQ 305
Query: 1019 GPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIE 1078
GP ET DFWRM+WEQ +ATIVM+T L+E+ KC QYWP++G TYG I+V++ D
Sbjct: 306 GPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTV 365
Query: 1079 LATFCVRTFSLHKNGSSEKRE----VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1134
L + VR F + + G R+ + QF FT+WPD GVP P L FL++VK CNP
Sbjct: 366 LVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQY 425
Query: 1135 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1194
AG IVVHCSAGVGRTG F+VIDAML+ + E+ VDVYG V+ +R+QR MVQT+ QY FI
Sbjct: 426 AGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFI 485
Query: 1195 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISAN 1254
++ALLE G+TE+ SL ++QK+ PG G+E EFK+L + K + + N
Sbjct: 486 YQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGN 545
Query: 1255 LPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETT 1314
LP N KNR++ I+PYE RV + RG E +DY+NASFIDGYRQ+ +YIA+QGPL T
Sbjct: 546 LPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTI 605
Query: 1315 EDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1374
EDFWRM+WE S +VMLT+L E G+EKC QYWP++ Y V+ E Y +R
Sbjct: 606 EDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVR 665
Query: 1375 EFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCS 1434
+ VT+ R+ +SR +RQF F WPE G+P G+G I I V K ++Q G + PI+VHCS
Sbjct: 666 DLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCS 724
Query: 1435 AGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG 1494
AG GRTG F LS VLER++ EG++D+FQTVK LR QRP MVQT ++Y+FCY+ EY+
Sbjct: 725 AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
Query: 1495 SFDHYA 1500
+F YA
Sbjct: 785 AFSDYA 790
>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
precursor [Homo sapiens]
Length = 700
Score = 552 bits (1423), Expect = e-157
Identities = 297/676 (43%), Positives = 416/676 (61%), Gaps = 32/676 (4%)
Query: 840 PDP---QPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN 896
PDP QP+ L W++ P+L ++ ++ + ++ + + S+ +
Sbjct: 39 PDPGASQPL------LAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKM------ 86
Query: 897 ADLAPHHPKDPVEMRRINFQT---PGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESI 953
P+ + E +R+ + G + PIP+ + E A+D + +E+ S+
Sbjct: 87 ----PNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSL 142
Query: 954 DPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQN 1012
G Q T+E +N E N+ KNRY N++ DHSRVIL ++GI SDYINA+Y+DGY+ +N
Sbjct: 143 PSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKN 202
Query: 1013 AYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVT 1072
+IA QGP ET DFWRMVWEQ+SATIVM+T L+E+ KC QYWP++G TYG I+V
Sbjct: 203 KFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVC 262
Query: 1073 LLDTIELATFCVRTFSLHK---NGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT 1129
+ D + L + +R F + +G R V Q FT+WPD GVP P L FL++VKT
Sbjct: 263 VEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKT 322
Query: 1130 CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTED 1189
NP AGPIVVHCSAGVGRTG FIVIDAM+ + E+ VDV+ V+ +R+QR MVQT+
Sbjct: 323 LNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDM 382
Query: 1190 QYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSR 1249
QY+FI++ALLE G+TE+ SL ++Q + G+E EF++L N +
Sbjct: 383 QYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKEN 442
Query: 1250 FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP 1309
+ NLP N K R++ I+PY+ RV L RG E +DYINASFIDGYRQ+ +IATQGP
Sbjct: 443 MRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGP 502
Query: 1310 LAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMP 1369
LA T EDFWRM+WE S +VMLT+++E ++KC+QYWP E S + ++ +
Sbjct: 503 LAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSE 562
Query: 1370 QYILREFKVT-----DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFG 1424
+R+F VT ++ Q R VRQF F WPE G+P G+G ID I V K ++Q G
Sbjct: 563 AISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG 622
Query: 1425 QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQF 1484
+ PI+VHCSAG GRTG FI LS +LER++ EG++D+FQ VK LR QRP MVQT ++Y+F
Sbjct: 623 -NHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEF 681
Query: 1485 CYQAALEYLGSFDHYA 1500
CY+ +++ F YA
Sbjct: 682 CYKVVQDFIDIFSDYA 697
>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
[Homo sapiens]
Length = 642
Score = 549 bits (1414), Expect = e-156
Identities = 283/585 (48%), Positives = 381/585 (65%), Gaps = 10/585 (1%)
Query: 925 PIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDH 983
PIP+ + E A+D + +E+ S+ G Q T+E +N E N+ KNRY N++ DH
Sbjct: 56 PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDH 115
Query: 984 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1043
SRVIL ++GI SDYINA+Y+DGY+ +N +IA QGP ET DFWRMVWEQ+SATIVM+
Sbjct: 116 SRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML 175
Query: 1044 TRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHK---NGSSEKREV 1100
T L+E+ KC QYWP++G TYG I+V + D + L + +R F + +G R V
Sbjct: 176 TNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLV 235
Query: 1101 RQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1160
Q FT+WPD GVP P L FL++VKT NP AGPIVVHCSAGVGRTG FIVIDAM+
Sbjct: 236 SQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMA 295
Query: 1161 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQK 1220
+ E+ VDV+ V+ +R+QR MVQT+ QY+FI++ALLE G+TE+ SL ++Q
Sbjct: 296 MMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQT 355
Query: 1221 LAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1280
+ G+E EF++L N + + NLP N K R++ I+PY+ RV L
Sbjct: 356 MHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMK 415
Query: 1281 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGR 1340
RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +VMLT+++E +
Sbjct: 416 RGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQ 475
Query: 1341 EKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTVRQFQFT 1395
+KC+QYWP E S + ++ + +R+F VT ++ Q R VRQF F
Sbjct: 476 DKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFH 535
Query: 1396 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1455
WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI LS +LER++
Sbjct: 536 GWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNILERVKA 594
Query: 1456 EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA 1500
EG++D+FQ VK LR QRP MVQT ++Y+FCY+ +++ F YA
Sbjct: 595 EGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 521 bits (1341), Expect = e-147
Identities = 379/1141 (33%), Positives = 563/1141 (49%), Gaps = 141/1141 (12%)
Query: 460 GNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLS---DPIQVKTQQGVPGQ-P 515
G+W + + ++ + L D Y +RVL T G+G P+ +T+ P + P
Sbjct: 335 GSWTETHAVNAPTYKLWHLDPDTEYEIRVL-LTRPGEGGTGLPGPPLITRTKCAEPMRTP 393
Query: 516 MNLRAEARSETSITLSWSPPRQE-------SIIKYELLFREGDHGREVGRTFDPTT-SYV 567
L+ I + W ++ FR + + DP +V
Sbjct: 394 KTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHV 453
Query: 568 VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTS----VLLSW 623
V L P T + ++ +P+G + Q T + + P VK + TS + L+W
Sbjct: 454 VNHLPPYTNVSLKMILTNPEGRKESEETIIQ-TDEDV-PGPVPVKSLQGTSFENKIFLNW 511
Query: 624 EFPDNYNSP-TPYKIQYNGL--------------TLDVDGRTTKKLITHLKPHTFYNFVL 668
+ P + N T Y+I Y+ + T+ +T + HL P T Y F +
Sbjct: 512 KEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFI 571
Query: 669 TNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF----------IMVYLPDGQSP- 717
R S++ G N+ S PD +G I V L Q+
Sbjct: 572 --RASTVKGFGPATAINVTTNI-----SAPTLPDYEGVDASLNETATTITVLLRPAQAKG 624
Query: 718 VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPY 777
P+ +Y IV+ L R + G+ E + Q+ + PY
Sbjct: 625 APISAYQIVVEELHPHRTKR---EAGAMECYQVPVTYQNA-------------MSGGAPY 668
Query: 778 IAARFSVLPP-------TFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFA--- 827
A + LPP F GD + Y GF N L P Y ++ A+ + T
Sbjct: 669 YFA--AELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCV 726
Query: 828 -----ASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSK 882
A+ +P + PDP D + + +L + ++ +VI +++ K+K K
Sbjct: 727 RIATKAAATEEPEVI--PDPAKQTDRVVKIAGISAGILVFILLLLVVI-LIVKKSKLAKK 783
Query: 883 RKDSEPRTKCLLNN---------ADLAPHHPKDPVE---MRRINFQ-------------- 916
RKD+ T+ + + AD + H +DP+ M + NF
Sbjct: 784 RKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSR 843
Query: 917 ---TPGMLS------------HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTW 961
P L HP I +AD+ +H +K +DS +EYES GQ +W
Sbjct: 844 LLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASW 903
Query: 962 EHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPL 1021
+ + + N+ KNRY N+IAYDHSRVILQP+E SDYINANY+DGY+ + YIATQGP+
Sbjct: 904 DVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPV 963
Query: 1022 PETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELAT 1081
ET DFWRM+W+++SA IVM+T L E R+KC +YWP+ TE YG +VT ++ LA
Sbjct: 964 HETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAE 1022
Query: 1082 FCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVH 1141
+ VRTF+L + G +E REV+QF FT WPDHGVP + T L+F+RRVK NPP AGPIVVH
Sbjct: 1023 YVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVH 1082
Query: 1142 CSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA 1201
CSAG GRTGC+IVID ML+ + E VD+Y V +RS+R MVQTE+QY FIH+A+LEA
Sbjct: 1083 CSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEA 1142
Query: 1202 VGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLPCNK 1259
CG T +P A + +++ + + ++ EF+ L + A LP N
Sbjct: 1143 CLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNH 1202
Query: 1260 FKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWR 1319
KNR ++++P + L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR
Sbjct: 1203 DKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWR 1261
Query: 1320 MLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREF 1376
++++ T +VML ++ + C QYWP E RY V+ M+ + ++ I R
Sbjct: 1262 LVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRIC 1319
Query: 1377 KVTDARDGQSRTVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCS 1434
+T ++G V+QFQ+ W + VP S F+ I QV K +E+ + +G +HC
Sbjct: 1320 NLTRPQEGY-LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCL 1378
Query: 1435 AGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG 1494
G GR+G+F + IV+E ++ + VVD+F VK LR +P MV+ ++Y+FCY ALEYL
Sbjct: 1379 NGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1438
Query: 1495 S 1495
S
Sbjct: 1439 S 1439
Score = 66.6 bits (161), Expect = 2e-10
Identities = 91/402 (22%), Positives = 150/402 (37%), Gaps = 69/402 (17%)
Query: 242 EIMPGGNVNITCVAVGSPMPYVK-WMQGAEDLTPEDDMPVG--RNV----------LELT 288
E+ G N C+A G + K W+Q +D+PV +N+ L+
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRNG----EDIPVAQTKNINHRRFAASFRLQEV 260
Query: 289 DVKDSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---P 344
D Y CV S G + AQ+ V+ P+ P + T + I ++ +
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Query: 345 DPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSE 402
P+ +EY+ S G + + Y + L P++EYEI V + G G P
Sbjct: 321 GPIILKEVEYRMTS--GSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
Query: 403 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRV--YYTMEPEHPVG 460
++TRT P P+ ++ + A + V WE GY + +T
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
Query: 461 NWQKHN--------VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP 512
++ HN +D V + L T + T+ S+ ++T + VP
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP 490
Query: 513 GQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP------- 562
G P+ E I L+W P + I +YE+ + R+FDP
Sbjct: 491 GPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSS-------IRSFDPAVPVAGP 543
Query: 563 ---------TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV 595
+T +V L P T Y F + A + +G G T +
Sbjct: 544 PQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAI 585
Score = 46.2 bits (108), Expect = 2e-04
Identities = 53/248 (21%), Positives = 96/248 (38%), Gaps = 20/248 (8%)
Query: 320 KAPGTPMVTENTATSITITWDSGNPDPVSYYVIE-------YKSKSQDGPYQIKEDITTT 372
+ P T + E A I + W+S + + ++ ++ + D
Sbjct: 391 RTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAP 450
Query: 373 RYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIV 432
++ + L P + + + N G+ SE + +T E P P + +
Sbjct: 451 QHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFL 509
Query: 433 QWEEPVEPNGLIRGYRVYY----TMEPEHPVGNWQK--HNVDDSLLTTVGSLLEDETYTV 486
W+EP++PNG+I Y + Y + +P PV + N+ +S L TY
Sbjct: 510 NWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQF 569
Query: 487 RVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA---RSETSITLSWSPPRQES--II 541
+ A T G GP + I V T P P +A + T+IT+ P + + I
Sbjct: 570 FIRASTVKGFGP-ATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPIS 628
Query: 542 KYELLFRE 549
Y+++ E
Sbjct: 629 AYQIVVEE 636
Score = 32.3 bits (72), Expect = 3.5
Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 30 EEPPRFIKEPKDQIGVSGGVASFVCQATG-DPKPRVTW--NKKGKKVNSQRFETIEFDES 86
++ P F++ ++ +G A+F C ATG D W + G+ + + + I
Sbjct: 193 DKSPHFLRLGDVEVN-AGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRF 251
Query: 87 AGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPN-IDMGPQLKV 145
A A R+Q + T D+++Y CV Q+ G + ++RE P P + +GP +
Sbjct: 252 A-ASFRLQEV-TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLL 309
Query: 146 VE 147
++
Sbjct: 310 IQ 311
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 514 bits (1324), Expect = e-145
Identities = 379/1147 (33%), Positives = 563/1147 (49%), Gaps = 147/1147 (12%)
Query: 460 GNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLS---DPIQVKTQQGVPGQ-P 515
G+W + + ++ + L D Y +RVL T G+G P+ +T+ P + P
Sbjct: 335 GSWTETHAVNAPTYKLWHLDPDTEYEIRVL-LTRPGEGGTGLPGPPLITRTKCAEPMRTP 393
Query: 516 MNLRAEARSETSITLSWSPPRQE-------SIIKYELLFREGDHGREVGRTFDPTT-SYV 567
L+ I + W ++ FR + + DP +V
Sbjct: 394 KTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHV 453
Query: 568 VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTS----VLLSW 623
V L P T + ++ +P+G + Q T + + P VK + TS + L+W
Sbjct: 454 VNHLPPYTNVSLKMILTNPEGRKESEETIIQ-TDEDV-PGPVPVKSLQGTSFENKIFLNW 511
Query: 624 EFPDNYNSP-TPYKIQYNGL--------------TLDVDGRTTKKLITHLKPHTFYNFVL 668
+ P + N T Y+I Y+ + T+ +T + HL P T Y F +
Sbjct: 512 KEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFI 571
Query: 669 TNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF----------IMVYLPDGQSP- 717
R S++ G N+ S PD +G I V L Q+
Sbjct: 572 --RASTVKGFGPATAINVTTNI-----SAPTLPDYEGVDASLNETATTITVLLRPAQAKG 624
Query: 718 VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPY 777
P+ +Y IV+ L R + G+ E + Q+ + PY
Sbjct: 625 APISAYQIVVEELHPHRTKR---EAGAMECYQVPVTYQNA-------------MSGGAPY 668
Query: 778 IAARFSVLPP-------TFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFA--- 827
A + LPP F GD + Y GF N L P Y ++ A+ + T
Sbjct: 669 YFA--AELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCV 726
Query: 828 -----ASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSK 882
A+ +P + PDP D + + +L + ++ +VI +++ K+K K
Sbjct: 727 RIATKAAATEEPEVI--PDPAKQTDRVVKIAGISAGILVFILLLLVVI-LIVKKSKLAKK 783
Query: 883 RKDSEPRTKCLLNN---------ADLAPHHPKDPVE---MRRINFQ-------------- 916
RKD+ T+ + + AD + H +DP+ M + NF
Sbjct: 784 RKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSR 843
Query: 917 ---TPGMLS------------HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTW 961
P L HP I +AD+ +H +K +DS +EYES GQ +W
Sbjct: 844 LLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASW 903
Query: 962 EHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVD------GYRCQNAYI 1015
+ + + N+ KNRY N+IAYDHSRVILQP+E SDYINANY+D GY+ + YI
Sbjct: 904 DVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYI 963
Query: 1016 ATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLD 1075
ATQGP+ ET DFWRM+W+++SA IVM+T L E R+KC +YWP+ TE YG +VT ++
Sbjct: 964 ATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVE 1022
Query: 1076 TIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDA 1135
LA + VRTF+L + G +E REV+QF FT WPDHGVP + T L+F+RRVK NPP A
Sbjct: 1023 MEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSA 1082
Query: 1136 GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIH 1195
GPIVVHCSAG GRTGC+IVID ML+ + E VD+Y V +RS+R MVQTE+QY FIH
Sbjct: 1083 GPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIH 1142
Query: 1196 EALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFISA 1253
+A+LEA CG T +P A + +++ + + ++ EF+ L + A
Sbjct: 1143 DAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIA 1202
Query: 1254 NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAET 1313
LP N KNR ++++P + L I G E S+YINA+ +D YRQ A+I TQ PL T
Sbjct: 1203 CLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNT 1261
Query: 1314 TEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQ 1370
+DFWR++++ T +VML ++ + C QYWP E RY V+ M+ + ++
Sbjct: 1262 VKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVIN 1319
Query: 1371 YILREFKVTDARDGQSRTVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGP 1428
I R +T ++G V+QFQ+ W + VP S F+ I QV K +E+ + +G
Sbjct: 1320 RIFRICNLTRPQEGY-LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGR 1378
Query: 1429 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQA 1488
+HC G GR+G+F + IV+E ++ + VVD+F VK LR +P MV+ ++Y+FCY
Sbjct: 1379 TIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDV 1438
Query: 1489 ALEYLGS 1495
ALEYL S
Sbjct: 1439 ALEYLES 1445
Score = 66.6 bits (161), Expect = 2e-10
Identities = 91/402 (22%), Positives = 150/402 (37%), Gaps = 69/402 (17%)
Query: 242 EIMPGGNVNITCVAVGSPMPYVK-WMQGAEDLTPEDDMPVG--RNV----------LELT 288
E+ G N C+A G + K W+Q +D+PV +N+ L+
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRNG----EDIPVAQTKNINHRRFAASFRLQEV 260
Query: 289 DVKDSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---P 344
D Y CV S G + AQ+ V+ P+ P + T + I ++ +
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Query: 345 DPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSE 402
P+ +EY+ S G + + Y + L P++EYEI V + G G P
Sbjct: 321 GPIILKEVEYRMTS--GSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
Query: 403 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRV--YYTMEPEHPVG 460
++TRT P P+ ++ + A + V WE GY + +T
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
Query: 461 NWQKHN--------VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP 512
++ HN +D V + L T + T+ S+ ++T + VP
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP 490
Query: 513 GQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP------- 562
G P+ E I L+W P + I +YE+ + R+FDP
Sbjct: 491 GPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSS-------IRSFDPAVPVAGP 543
Query: 563 ---------TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV 595
+T +V L P T Y F + A + +G G T +
Sbjct: 544 PQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAI 585
Score = 46.2 bits (108), Expect = 2e-04
Identities = 53/248 (21%), Positives = 96/248 (38%), Gaps = 20/248 (8%)
Query: 320 KAPGTPMVTENTATSITITWDSGNPDPVSYYVIE-------YKSKSQDGPYQIKEDITTT 372
+ P T + E A I + W+S + + ++ ++ + D
Sbjct: 391 RTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAP 450
Query: 373 RYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIV 432
++ + L P + + + N G+ SE + +T E P P + +
Sbjct: 451 QHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFL 509
Query: 433 QWEEPVEPNGLIRGYRVYY----TMEPEHPVGNWQK--HNVDDSLLTTVGSLLEDETYTV 486
W+EP++PNG+I Y + Y + +P PV + N+ +S L TY
Sbjct: 510 NWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQF 569
Query: 487 RVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA---RSETSITLSWSPPRQES--II 541
+ A T G GP + I V T P P +A + T+IT+ P + + I
Sbjct: 570 FIRASTVKGFGP-ATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPIS 628
Query: 542 KYELLFRE 549
Y+++ E
Sbjct: 629 AYQIVVEE 636
Score = 32.3 bits (72), Expect = 3.5
Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 30 EEPPRFIKEPKDQIGVSGGVASFVCQATG-DPKPRVTW--NKKGKKVNSQRFETIEFDES 86
++ P F++ ++ +G A+F C ATG D W + G+ + + + I
Sbjct: 193 DKSPHFLRLGDVEVN-AGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRF 251
Query: 87 AGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPN-IDMGPQLKV 145
A A R+Q + T D+++Y CV Q+ G + ++RE P P + +GP +
Sbjct: 252 A-ASFRLQEV-TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLL 309
Query: 146 VE 147
++
Sbjct: 310 IQ 311
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 506 bits (1304), Expect = e-143
Identities = 372/1208 (30%), Positives = 571/1208 (47%), Gaps = 155/1208 (12%)
Query: 403 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNW 462
S V+ E P + L A W +P + + G + +E G W
Sbjct: 275 SGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTW 334
Query: 463 QKHNVDDSLLTTVGSLLEDETYTVRVLAFT--SVGDGPLSDPIQVKTQQGVPGQ-PMNLR 519
+ ++ DS + L D Y +RVL G GP P+ +T+ P P N+
Sbjct: 335 AETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVE 394
Query: 520 AEARSETSITLSWSP--------PRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDL 571
+TL W P ++Y+ +F + + E ++ Y + L
Sbjct: 395 IVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQY--EAEEVIQTSSHYTLRGL 452
Query: 572 KPNTEYAFRLAARSPQGLGAFTPVVRQRT--------LQSISPKNFKVKMIMKTSVLLSW 623
+P RL +P+G +V Q L+SI F+ K + + W
Sbjct: 453 RPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEK------IYIQW 506
Query: 624 EFPDNYNSP-TPYKIQYNGL-TLDVDG-------------RTTKKLITHLKPHTFYNFVL 668
+ P+ N T Y+I Y + +LD T L L P T Y+F +
Sbjct: 507 KPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTI 566
Query: 669 TNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQS---PVP 719
+ S+ G VT A + PS+ P + D I V L QS PV
Sbjct: 567 --KASTAKGFGPPVTTRIATKI--SAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVS 622
Query: 720 VQSYFIVMVPLRKSRGGQ-----FLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVP 774
V + L+KSR F P+ L+ L + L+ +L V
Sbjct: 623 VYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANL------PVT 676
Query: 775 RPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFA-----AS 829
+P+ GD K Y G+ N L P Y ++ A+ + + T A+
Sbjct: 677 QPFTV------------GDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLAT 724
Query: 830 PFSDPFQLDNPDPQPIVDGEEGLIWVI-GPVLAVVFIICIVIAILLYKN--------KPD 880
+ + +P+ VD + VI G ++ ++ ++ +++ I +N K
Sbjct: 725 KGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLA 784
Query: 881 SKRKDSE---------------PRTKCLLNNADLA------------------------- 900
K+K+++ P TK + D
Sbjct: 785 KKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLT 844
Query: 901 ----PHHPKDPVEMR--RINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID 954
P+ DPVEM R FQ P I +AD+ +H ++K +EYE++
Sbjct: 845 IQTHPYRTCDPVEMSYPRDQFQ-------PAIRVADLLQHITQMKRGQGYGFKEEYEALP 897
Query: 955 PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAY 1014
GQ +W+ + + N+ KNRY N+I+YDHSRV L ++G SDYINANY+DGY Y
Sbjct: 898 EGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHY 957
Query: 1015 IATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL 1074
IATQGP+ ET DFWRM+W++ SA+IVM+T L E R+KC +YWP+ TE YG I+VTL+
Sbjct: 958 IATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLI 1016
Query: 1075 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1134
+T LA + +RTF++ K G E RE+R F FT+WPDHGVP Y T L F+R+VK NPP+
Sbjct: 1017 ETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPE 1076
Query: 1135 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1194
AGPIVVHCSAG GRTGCFI ID ML+ + E VD++ V +R+QR +VQTE+QY F+
Sbjct: 1077 AGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFV 1136
Query: 1195 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFIS 1252
H+A+LEA CGNT +P + +++++P + + ++ EF+ L +
Sbjct: 1137 HDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSI 1196
Query: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312
LP N KNR ++++P + L + G E S+YINA+ +D ++Q A++ TQ PL
Sbjct: 1197 GLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPN 1255
Query: 1313 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYI 1372
T DFWR++++ N + VVML ++ + C QYWP + S Y V+ ++ I
Sbjct: 1256 TVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDII 1313
Query: 1373 LREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF-GQDGP 1428
R F++ + Q R V+ Q+ WP + P S + + ++ K +EQ+ G++G
Sbjct: 1314 HRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGR 1373
Query: 1429 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQA 1488
VHC G GR+G F + V E ++ + ++D+F VK LR + MV+T ++Y+F Y+
Sbjct: 1374 TVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEV 1433
Query: 1489 ALEYLGSF 1496
ALEYL SF
Sbjct: 1434 ALEYLSSF 1441
Score = 84.0 bits (206), Expect = 1e-15
Identities = 106/412 (25%), Positives = 171/412 (41%), Gaps = 49/412 (11%)
Query: 229 RVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK-WMQ---GAEDLTPEDDMPVGRNV 284
R AP F L + E+ G N C+A G + K W+Q G + + R
Sbjct: 190 RKAPHFLRL-QNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRF 248
Query: 285 LELTDVKDSAN-----YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITIT 338
V D+A Y CV S G + A++ VK P P E A T
Sbjct: 249 SATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL 305
Query: 339 WDSGNPD------PVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--S 390
W N + P+ +EY++ + G + + + Y + L P+ EYEI V +
Sbjct: 306 WIKPNANSIIGDGPIILKEVEYRTTT--GTWAETHIVDSPNYKLWHLDPDVEYEIRVLLT 363
Query: 391 AVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNG--LIRGYR 448
G GPP + TRT P P+NV+ + A + +QW EP G + R +
Sbjct: 364 RPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHS 419
Query: 449 VYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLED--ETYTVRVLAFTSVGDGPL-SDPIQV 505
T++ ++ V N Q++ ++ + T+ L T+R+ S +G + S+ + V
Sbjct: 420 YNLTVQYQY-VFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVV 478
Query: 506 KTQQGVPGQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFR-------EGDHGRE 555
+T++ VPG P+ E I + W PP + + I YE+ ++ D +
Sbjct: 479 QTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQ 538
Query: 556 VGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSIS 605
G+ F T ++ L P T Y+F + A + +G G P V R IS
Sbjct: 539 RGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFG---PPVTTRIATKIS 587
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 498 bits (1283), Expect = e-140
Identities = 276/609 (45%), Positives = 373/609 (61%), Gaps = 16/609 (2%)
Query: 895 NNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID 954
+ + L H E + +QT G L HP I +AD+ +H ++K + +EYES
Sbjct: 851 DTSSLVQSHTYKKREPADVPYQT-GQL-HPAIRVADLLQHITQMKCAEGYGFKEEYESFF 908
Query: 955 PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAY 1014
GQ W+ + + N+ KNRY N+IAYDHSRV LQ IEG SDYIN NY+DGY N Y
Sbjct: 909 EGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHY 968
Query: 1015 IATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL 1074
IATQGP+ ET DFWRMVW + +A+I+M+T L E R+KC +YWP+ TE Y I+VTL+
Sbjct: 969 IATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLI 1027
Query: 1075 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1134
+T LA + +RTF++ K G E RE+RQF FT WPDHGVP + T L F+R+VK+ +PP
Sbjct: 1028 ETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPS 1087
Query: 1135 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1194
AGP+VVHCSAG GRTGCFIVID ML+ + E VD+Y V +RS+R MVQTE+QY FI
Sbjct: 1088 AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFI 1147
Query: 1195 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFIS-- 1252
H+A+LEA CG+T VPA + + + +++P + + ++ EF+ L N T R
Sbjct: 1148 HDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTL-NMVTPTLRVEDCS 1206
Query: 1253 -ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1311
A LP N KNR ++I+P + L I G E S+YINA+ +D Y+Q A+I TQ PL
Sbjct: 1207 IALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLP 1265
Query: 1312 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP---AERSARYQYFVVDPMAEYNM 1368
T +DFWR++ + + T VVML + + C QYWP R Q V E ++
Sbjct: 1266 NTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDI 1323
Query: 1369 PQYILREFKVTDARDGQSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQD 1426
I R + +DG R V+QFQF WP + P S F+ I QV K +E++ G +
Sbjct: 1324 ISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGE 1382
Query: 1427 GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1486
G VHC G GR+G F +SIV E +R++ VD+F VK LR +P MV D+Y+FCY
Sbjct: 1383 GRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCY 1442
Query: 1487 QAALEYLGS 1495
+ ALEYL S
Sbjct: 1443 EVALEYLNS 1451
Score = 133 bits (334), Expect = 1e-30
Identities = 83/243 (34%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 969 NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDF 1028
N KNR +++ D L I+G S+YINA +D Y+ +A+I TQ PLP T DF
Sbjct: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271
Query: 1029 WRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFS 1088
WR+V + ++VM+ ++ C QYWP G +G IQV + R F
Sbjct: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329
Query: 1089 LHKNGSSEK--REVRQFQFTAWPDH-GVPEYPTPFLAFLRRVKTCNPP---DAGPIVVHC 1142
++ + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1330 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1389
Query: 1143 SAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1202
G GR+G F I + E ++ ++TVDV+ V +R+ + MV DQY F +E LE +
Sbjct: 1390 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1449
Query: 1203 GCG 1205
G
Sbjct: 1450 NSG 1452
Score = 77.0 bits (188), Expect = 1e-13
Identities = 97/400 (24%), Positives = 167/400 (41%), Gaps = 43/400 (10%)
Query: 242 EIMPGGNVNITCVAVGSPMPYVK-WMQGAE---------DLTPEDDMPVGRNVLELTDVK 291
E+ G C A+G + + W+QG + +T NV+ T +
Sbjct: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK-R 253
Query: 292 DSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPD---PV 347
D+ Y C+ + GV I A++ VK P P + AT + I ++ + + P+
Sbjct: 254 DAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPI 313
Query: 348 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVV 405
+EY + S G + ++ + +T Y IG L P++EYEI V + G G P ++
Sbjct: 314 VAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALR 371
Query: 406 TRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKH 465
TRT P PR ++ + + + ++W EP N + R + T+ + VG ++
Sbjct: 372 TRTKCADPMRGPRKLEVVEVKSRQITIRW-EPFGYN-VTRCHSYNLTVHYCYQVGGQEQV 429
Query: 466 NVDDSLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMN 517
+ S T T+ +L +V+++ G S + V+T + +PG P
Sbjct: 430 REEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTE 488
Query: 518 LRAEARSETSITLSWSPPRQE--SIIKYELLFR-------EGDHGREVGRT--FDPTTSY 566
+ E I L W P Q I YE+ ++ E D + GR T +
Sbjct: 489 SIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHF 548
Query: 567 VVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISP 606
+ L P T Y+F + A + +G G P Q T + +P
Sbjct: 549 LFFGLYPGTTYSFTIRASTAKGFG--PPATNQFTTKISAP 586
Score = 55.5 bits (132), Expect = 4e-07
Identities = 111/482 (23%), Positives = 174/482 (36%), Gaps = 75/482 (15%)
Query: 460 GNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDP---IQVKTQQGVPGQ-P 515
G+W DS +G L D Y + VL T G+G P ++ +T+ P + P
Sbjct: 325 GSWNDRQPVDSTSYKIGHLDPDTEYEISVL-LTRPGEGGTGSPGPALRTRTKCADPMRGP 383
Query: 516 MNLRAEARSETSITLSWSP-----PRQESI-IKYELLFREGDHGREVGR------TFDPT 563
L IT+ W P R S + ++ G G+E R T +
Sbjct: 384 RKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVG--GQEQVREEVSWDTENSH 441
Query: 564 TSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQ--RTLQSISPKNFKVKMIMKTSVLL 621
+ + +L P T + +L +P+G ++ Q L P + + L
Sbjct: 442 PQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFL 501
Query: 622 SWEFP-DNYNSPTPYKIQYNGLTL---DVD-----------GRTTKKLITHLKPHTFYNF 666
W P Y T Y+I Y ++ ++D G T L L P T Y+F
Sbjct: 502 QWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSF 561
Query: 667 VLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQSP-VP 719
+ R S+ G T F PS+ P D + V L S P
Sbjct: 562 TI--RASTAKGFGPPAT--NQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAP 617
Query: 720 VQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIA 779
V Y IV+ R R + + ++ + Q SL +S+ Y A
Sbjct: 618 VSVYQIVVEEERPRR---------TKKTTEILKCYPVPIHFQNASLLNSQY------YFA 662
Query: 780 ARFSV----LPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT------FAAS 829
A F F GD K Y G+ N L P Y ++ A + + T A
Sbjct: 663 AEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATK 722
Query: 830 PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR 889
+ P + P+P+ D + VI +L V II + + +++ K K KRK++
Sbjct: 723 GAATPKPV--PEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKETMSS 779
Query: 890 TK 891
T+
Sbjct: 780 TR 781
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 498 bits (1283), Expect = e-140
Identities = 276/609 (45%), Positives = 373/609 (61%), Gaps = 16/609 (2%)
Query: 895 NNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID 954
+ + L H E + +QT G L HP I +AD+ +H ++K + +EYES
Sbjct: 864 DTSSLVQSHTYKKREPADVPYQT-GQL-HPAIRVADLLQHITQMKCAEGYGFKEEYESFF 921
Query: 955 PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAY 1014
GQ W+ + + N+ KNRY N+IAYDHSRV LQ IEG SDYIN NY+DGY N Y
Sbjct: 922 EGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHY 981
Query: 1015 IATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL 1074
IATQGP+ ET DFWRMVW + +A+I+M+T L E R+KC +YWP+ TE Y I+VTL+
Sbjct: 982 IATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLI 1040
Query: 1075 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1134
+T LA + +RTF++ K G E RE+RQF FT WPDHGVP + T L F+R+VK+ +PP
Sbjct: 1041 ETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPS 1100
Query: 1135 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1194
AGP+VVHCSAG GRTGCFIVID ML+ + E VD+Y V +RS+R MVQTE+QY FI
Sbjct: 1101 AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFI 1160
Query: 1195 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFIS-- 1252
H+A+LEA CG+T VPA + + + +++P + + ++ EF+ L N T R
Sbjct: 1161 HDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTL-NMVTPTLRVEDCS 1219
Query: 1253 -ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1311
A LP N KNR ++I+P + L I G E S+YINA+ +D Y+Q A+I TQ PL
Sbjct: 1220 IALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLP 1278
Query: 1312 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP---AERSARYQYFVVDPMAEYNM 1368
T +DFWR++ + + T VVML + + C QYWP R Q V E ++
Sbjct: 1279 NTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDI 1336
Query: 1369 PQYILREFKVTDARDGQSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQD 1426
I R + +DG R V+QFQF WP + P S F+ I QV K +E++ G +
Sbjct: 1337 ISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGE 1395
Query: 1427 GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1486
G VHC G GR+G F +SIV E +R++ VD+F VK LR +P MV D+Y+FCY
Sbjct: 1396 GRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCY 1455
Query: 1487 QAALEYLGS 1495
+ ALEYL S
Sbjct: 1456 EVALEYLNS 1464
Score = 133 bits (334), Expect = 1e-30
Identities = 83/243 (34%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 969 NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDF 1028
N KNR +++ D L I+G S+YINA +D Y+ +A+I TQ PLP T DF
Sbjct: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284
Query: 1029 WRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFS 1088
WR+V + ++VM+ ++ C QYWP G +G IQV + R F
Sbjct: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342
Query: 1089 LHKNGSSEK--REVRQFQFTAWPDH-GVPEYPTPFLAFLRRVKTCNPP---DAGPIVVHC 1142
++ + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1343 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1402
Query: 1143 SAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1202
G GR+G F I + E ++ ++TVDV+ V +R+ + MV DQY F +E LE +
Sbjct: 1403 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1462
Query: 1203 GCG 1205
G
Sbjct: 1463 NSG 1465
Score = 77.0 bits (188), Expect = 1e-13
Identities = 97/400 (24%), Positives = 167/400 (41%), Gaps = 43/400 (10%)
Query: 242 EIMPGGNVNITCVAVGSPMPYVK-WMQGAE---------DLTPEDDMPVGRNVLELTDVK 291
E+ G C A+G + + W+QG + +T NV+ T +
Sbjct: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK-R 253
Query: 292 DSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPD---PV 347
D+ Y C+ + GV I A++ VK P P + AT + I ++ + + P+
Sbjct: 254 DAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPI 313
Query: 348 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVV 405
+EY + S G + ++ + +T Y IG L P++EYEI V + G G P ++
Sbjct: 314 VAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALR 371
Query: 406 TRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKH 465
TRT P PR ++ + + + ++W EP N + R + T+ + VG ++
Sbjct: 372 TRTKCADPMRGPRKLEVVEVKSRQITIRW-EPFGYN-VTRCHSYNLTVHYCYQVGGQEQV 429
Query: 466 NVDDSLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMN 517
+ S T T+ +L +V+++ G S + V+T + +PG P
Sbjct: 430 REEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTE 488
Query: 518 LRAEARSETSITLSWSPPRQE--SIIKYELLFR-------EGDHGREVGRT--FDPTTSY 566
+ E I L W P Q I YE+ ++ E D + GR T +
Sbjct: 489 SIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHF 548
Query: 567 VVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISP 606
+ L P T Y+F + A + +G G P Q T + +P
Sbjct: 549 LFFGLYPGTTYSFTIRASTAKGFG--PPATNQFTTKISAP 586
Score = 55.5 bits (132), Expect = 4e-07
Identities = 111/482 (23%), Positives = 174/482 (36%), Gaps = 75/482 (15%)
Query: 460 GNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDP---IQVKTQQGVPGQ-P 515
G+W DS +G L D Y + VL T G+G P ++ +T+ P + P
Sbjct: 325 GSWNDRQPVDSTSYKIGHLDPDTEYEISVL-LTRPGEGGTGSPGPALRTRTKCADPMRGP 383
Query: 516 MNLRAEARSETSITLSWSP-----PRQESI-IKYELLFREGDHGREVGR------TFDPT 563
L IT+ W P R S + ++ G G+E R T +
Sbjct: 384 RKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVG--GQEQVREEVSWDTENSH 441
Query: 564 TSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQ--RTLQSISPKNFKVKMIMKTSVLL 621
+ + +L P T + +L +P+G ++ Q L P + + L
Sbjct: 442 PQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFL 501
Query: 622 SWEFP-DNYNSPTPYKIQYNGLTL---DVD-----------GRTTKKLITHLKPHTFYNF 666
W P Y T Y+I Y ++ ++D G T L L P T Y+F
Sbjct: 502 QWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSF 561
Query: 667 VLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQSP-VP 719
+ R S+ G T F PS+ P D + V L S P
Sbjct: 562 TI--RASTAKGFGPPAT--NQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAP 617
Query: 720 VQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIA 779
V Y IV+ R R + + ++ + Q SL +S+ Y A
Sbjct: 618 VSVYQIVVEEERPRR---------TKKTTEILKCYPVPIHFQNASLLNSQY------YFA 662
Query: 780 ARFSV----LPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT------FAAS 829
A F F GD K Y G+ N L P Y ++ A + + T A
Sbjct: 663 AEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATK 722
Query: 830 PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR 889
+ P + P+P+ D + VI +L V II + + +++ K K KRK++
Sbjct: 723 GAATPKPV--PEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKETMSS 779
Query: 890 TK 891
T+
Sbjct: 780 TR 781
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 473 bits (1217), Expect = e-133
Identities = 251/604 (41%), Positives = 368/604 (60%), Gaps = 19/604 (3%)
Query: 901 PHHPKDPVEMR--RINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQ 958
P+ DPVEM R FQ P I +AD+ +H ++K +EYE++ GQ
Sbjct: 868 PYRTCDPVEMSYPRDQFQ-------PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQT 920
Query: 959 FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQ 1018
+W+ + + N+ KNRY N+I+YDHSRV L ++G SDYINANY+DGY YIATQ
Sbjct: 921 ASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQ 980
Query: 1019 GPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIE 1078
GP+ ET DFWRM+W++ SA+IVM+T L E R+KC +YWP+ TE YG I+VTL++T
Sbjct: 981 GPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIETEP 1039
Query: 1079 LATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPI 1138
LA + +RTF++ K G E RE+R F FT+WPDHGVP Y T L F+R+VK NPP+AGPI
Sbjct: 1040 LAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPI 1099
Query: 1139 VVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1198
VVHCSAG GRTGCFI ID ML+ + E VD++ V +R+QR +VQTE+QY F+H+A+
Sbjct: 1100 VVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1159
Query: 1199 LEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLP 1256
LEA CGNT +P + +++++P + + ++ EF+ L + LP
Sbjct: 1160 LEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLP 1219
Query: 1257 CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1316
N KNR ++++P + L + G E S+YINA+ +D ++Q A++ TQ PL T D
Sbjct: 1220 RNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVAD 1278
Query: 1317 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1376
FWR++++ N + VVML ++ + C QYWP + S Y V+ ++ I R F
Sbjct: 1279 FWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIF 1336
Query: 1377 KVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVH 1432
++ + Q R V+ Q+ WP + P S + + ++ K +EQ+ G++G VH
Sbjct: 1337 RICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVH 1396
Query: 1433 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 1492
C G GR+G F + V E ++ + ++D+F VK LR + MV+T ++Y+F Y+ ALEY
Sbjct: 1397 CLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY 1456
Query: 1493 LGSF 1496
L SF
Sbjct: 1457 LSSF 1460
Score = 84.0 bits (206), Expect = 1e-15
Identities = 106/412 (25%), Positives = 171/412 (41%), Gaps = 49/412 (11%)
Query: 229 RVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK-WMQ---GAEDLTPEDDMPVGRNV 284
R AP F L + E+ G N C+A G + K W+Q G + + R
Sbjct: 190 RKAPHFLRL-QNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRF 248
Query: 285 LELTDVKDSAN-----YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITIT 338
V D+A Y CV S G + A++ VK P P E A T
Sbjct: 249 SATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL 305
Query: 339 WDSGNPD------PVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--S 390
W N + P+ +EY++ + G + + + Y + L P+ EYEI V +
Sbjct: 306 WIKPNANSIIGDGPIILKEVEYRTTT--GTWAETHIVDSPNYKLWHLDPDVEYEIRVLLT 363
Query: 391 AVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNG--LIRGYR 448
G GPP + TRT P P+NV+ + A + +QW EP G + R +
Sbjct: 364 RPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHS 419
Query: 449 VYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLED--ETYTVRVLAFTSVGDGPL-SDPIQV 505
T++ ++ V N Q++ ++ + T+ L T+R+ S +G + S+ + V
Sbjct: 420 YNLTVQYQY-VFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVV 478
Query: 506 KTQQGVPGQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFR-------EGDHGRE 555
+T++ VPG P+ E I + W PP + + I YE+ ++ D +
Sbjct: 479 QTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQ 538
Query: 556 VGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSIS 605
G+ F T ++ L P T Y+F + A + +G G P V R IS
Sbjct: 539 RGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFG---PPVTTRIATKIS 587
>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
precursor [Homo sapiens]
Length = 1436
Score = 462 bits (1189), Expect = e-129
Identities = 351/1114 (31%), Positives = 521/1114 (46%), Gaps = 134/1114 (12%)
Query: 481 DETYTVRVLAFTSVGDGPLS---DPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPR 536
D Y + VL T GDG P+ +T+ P + P L +TL W P
Sbjct: 350 DTEYEISVL-LTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLG 408
Query: 537 QESI----------IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSP 586
Y L RE +T + Y +++L P RL +P
Sbjct: 409 YNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNP 468
Query: 587 QGLGAFTPVVRQRTLQSISPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNG 641
+G V Q T + + P + + ++ + L WE P N T Y+I Y
Sbjct: 469 EGRKEGKEVTFQ-TDEDV-PSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQS 526
Query: 642 L-----TLDVDG--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTA 684
+ ++V G RT KL ++L P T Y F + T +G L + T
Sbjct: 527 IESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTN 586
Query: 685 WTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQF 738
+A + + +P +++ I V L Q P+ Y +++ LR+ GGQ
Sbjct: 587 ISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQD 645
Query: 739 LTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQ 796
P+ + L R L H E+ S LP F GD +
Sbjct: 646 CFPVPLTFEAALA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQT 687
Query: 797 YGGFDNRGLEPGHRYVLFVLAVLQ-KSEPTFAASPFSDPFQL-DNPDPQPIVDGEEGLIW 854
Y GF N LEP Y+++ A K E + ++ P + E +
Sbjct: 688 YRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGL 747
Query: 855 VIGPV---LAVVFIICIVIAILLYKNKPDSKRKDS------------------------- 886
++G LAV+ ++ I +++ K KP + K +
Sbjct: 748 ILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQ 807
Query: 887 -------------------EPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIP 927
+ R+ + + L P+ P + + T G L HP +
Sbjct: 808 EDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHT-GQL-HPAVR 865
Query: 928 IADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVI 987
+AD+ +H ++K + QEYES G W+ + + +R + AYD RV
Sbjct: 866 VADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVK 921
Query: 988 LQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLE 1047
L P+ G +DYINANY+DGY N +IATQGP PE DFWRMVW++ ++IVM+T+L
Sbjct: 922 LHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLV 981
Query: 1048 EKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTA 1107
E R+KC +YWP ++TYG I++ L+ T LA + VRTF+L + G S + EVRQF FTA
Sbjct: 982 EVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTA 1040
Query: 1108 WPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKT 1167
WP+HGVP + T LAF+RRVK PPDAGPIV+HCSAG GRTGC+IV+D ML+ + E
Sbjct: 1041 WPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGV 1100
Query: 1168 VDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPG 1227
VD+Y V + S+R M+QTE+QY FIH+A+LEA CG T +P A +++ +++P
Sbjct: 1101 VDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQ 1160
Query: 1228 EHVTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG 1285
+ + + EF+ L A LP N+ KNR ++++P + CL + +G
Sbjct: 1161 SNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFLISTDG 1217
Query: 1286 --SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGRE-K 1342
++YINA+ D Y + A+I T PL TT DFWR++++ T +VML +L +
Sbjct: 1218 DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWP 1277
Query: 1343 CHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE- 1399
C QYWP +Y V+ M+ + R F+V + Q VR FQF W
Sbjct: 1278 CLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAY 1337
Query: 1400 QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVV 1459
+ P S + F+ + +V K + + G DG VHC G GR+G F + VLE +R +V
Sbjct: 1338 RDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLV 1396
Query: 1460 DIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1493
D+F K LR +P MV+T D+Y FCY ALEYL
Sbjct: 1397 DVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1430
Score = 63.5 bits (153), Expect = 1e-09
Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)
Query: 296 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 351
Y CV+ + G + A++ VK P P + T + I ++ + P+
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Query: 352 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 409
IEY+ GP+ ++ Y + L P++EYEI V + G G P +++RT
Sbjct: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
Query: 410 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 469
P AP+ + + A + +QW EP+ N + R + ++ + +G+ + +
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437
Query: 470 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 522
+ T T+ +LL VR L T+ + +T + VP + AE+
Sbjct: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493
Query: 523 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 567
+ E I L W P++ + I +YE+ ++ + P T +V
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
Query: 568 VEDLKPNTEYAFRLAARSPQGLG 590
+L P T Y F + AR+ +G G
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFG 576
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 456 bits (1173), Expect = e-128
Identities = 267/687 (38%), Positives = 378/687 (55%), Gaps = 55/687 (8%)
Query: 854 WVIGPVL--AVVFI-ICIVIAILLY----------------KNKPDSKRKDSEPRTKCLL 894
W+I ++ A+ F+ + ++IA+L+Y + P S + + KC
Sbjct: 737 WIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCF- 795
Query: 895 NNADLAPHHPKDPVEMRRINFQTPGMLSHPP----IPIADMAEHTERLKANDSLKLSQEY 950
A + +D R + ++ ++ P IP+ +H L +N+ S+++
Sbjct: 796 ---QTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDF 852
Query: 951 ESID---PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG--IMGSDYINANYV 1005
E + T EHSN NK KNRY N++AYDHSRV L+P+ G SDYINANYV
Sbjct: 853 EEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYV 912
Query: 1006 DGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTET 1065
DGY AYIATQGPL TF DFWRM+WEQ + IVM+T L EK R KCDQYWP +E
Sbjct: 913 DGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEE 972
Query: 1066 YGFIQVTLLDTIELATFCVRTFSLHKN-----------GSSEKREVRQFQFTAWPDHGVP 1114
YG I VTL T A + VR FS+ G +R V Q+ +T WPD GVP
Sbjct: 973 YGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVP 1032
Query: 1115 EYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHV 1174
EY P L F+RR P+ GP++VHCSAGVGRTG +IVID+ML++IK + TV+V G +
Sbjct: 1033 EYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFL 1092
Query: 1175 TLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGME 1234
+R+QRNY+VQTE+QY FIH+ALLEA+ TEV + L++Y+ + G T +E
Sbjct: 1093 KHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVGGK-TRLE 1151
Query: 1235 LEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFI 1294
+FK + A SA CNK KNR +++P E RV L P+ G++G+DYINAS+I
Sbjct: 1152 KQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYI 1211
Query: 1295 DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA-ERSA 1353
GY + +I TQ PL TT+DFWRM+W++N+ I+VML + + ++ YWP+ E S
Sbjct: 1212 MGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREESM 1270
Query: 1354 RYQYFVV-----DPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEG 1408
+ F V D + N Q I+ +F + +D VR FQ WP P S
Sbjct: 1271 NCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST- 1329
Query: 1409 FIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKML 1468
+ I + +E +DGP VH G G+ L+ + +++ E VD+FQ KM+
Sbjct: 1330 -FELINVI--KEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMI 1386
Query: 1469 RTQRPAMVQTEDEYQFCYQAALEYLGS 1495
RP + ++YQF Y+A L + +
Sbjct: 1387 NLMRPGVFTDIEQYQFIYKAMLSLVST 1413
Score = 34.7 bits (78), Expect = 0.71
Identities = 18/92 (19%), Positives = 41/92 (44%), Gaps = 7/92 (7%)
Query: 499 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS-------PPRQESIIKYELLFREGD 551
L +P+ + + P++++ + ++T++ +SWS PP +I Y E +
Sbjct: 334 LENPLGTEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDE 393
Query: 552 HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA 583
+ + D + + P++ Y FR+ A
Sbjct: 394 KEKTFTKDSDKDLKATISHVSPDSLYLFRVQA 425
>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
precursor [Homo sapiens]
Length = 1442
Score = 456 bits (1172), Expect = e-127
Identities = 351/1120 (31%), Positives = 521/1120 (46%), Gaps = 140/1120 (12%)
Query: 481 DETYTVRVLAFTSVGDGPLS---DPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPR 536
D Y + VL T GDG P+ +T+ P + P L +TL W P
Sbjct: 350 DTEYEISVL-LTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLG 408
Query: 537 QESI----------IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSP 586
Y L RE +T + Y +++L P RL +P
Sbjct: 409 YNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNP 468
Query: 587 QGLGAFTPVVRQRTLQSISPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNG 641
+G V Q T + + P + + ++ + L WE P N T Y+I Y
Sbjct: 469 EGRKEGKEVTFQ-TDEDV-PSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQS 526
Query: 642 L-----TLDVDG--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTA 684
+ ++V G RT KL ++L P T Y F + T +G L + T
Sbjct: 527 IESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTN 586
Query: 685 WTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQF 738
+A + + +P +++ I V L Q P+ Y +++ LR+ GGQ
Sbjct: 587 ISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQD 645
Query: 739 LTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQ 796
P+ + L R L H E+ S LP F GD +
Sbjct: 646 CFPVPLTFEAALA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQT 687
Query: 797 YGGFDNRGLEPGHRYVLFVLAVLQ-KSEPTFAASPFSDPFQL-DNPDPQPIVDGEEGLIW 854
Y GF N LEP Y+++ A K E + ++ P + E +
Sbjct: 688 YRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGL 747
Query: 855 VIGPV---LAVVFIICIVIAILLYKNKPDSKRKDS------------------------- 886
++G LAV+ ++ I +++ K KP + K +
Sbjct: 748 ILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQ 807
Query: 887 -------------------EPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIP 927
+ R+ + + L P+ P + + T G L HP +
Sbjct: 808 EDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHT-GQL-HPAVR 865
Query: 928 IADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVI 987
+AD+ +H ++K + QEYES G W+ + + +R + AYD RV
Sbjct: 866 VADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVK 921
Query: 988 LQPIEGIMGSDYINANYVD------GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIV 1041
L P+ G +DYINANY+D GY N +IATQGP PE DFWRMVW++ ++IV
Sbjct: 922 LHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIV 981
Query: 1042 MMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVR 1101
M+T+L E R+KC +YWP ++TYG I++ L+ T LA + VRTF+L + G S + EVR
Sbjct: 982 MITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVR 1040
Query: 1102 QFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLER 1161
QF FTAWP+HGVP + T LAF+RRVK PPDAGPIV+HCSAG GRTGC+IV+D ML+
Sbjct: 1041 QFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDM 1100
Query: 1162 IKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKL 1221
+ E VD+Y V + S+R M+QTE+QY FIH+A+LEA CG T +P A +++
Sbjct: 1101 AECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEM 1160
Query: 1222 AQVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQP 1279
+++P + + + EF+ L A LP N+ KNR ++++P + CL
Sbjct: 1161 IRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPF 1217
Query: 1280 IRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLRE 1337
+ +G ++YINA+ D Y + A+I T PL TT DFWR++++ T +VML +L +
Sbjct: 1218 LISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQ 1277
Query: 1338 MGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQF 1394
C QYWP +Y V+ M+ + R F+V + Q VR FQF
Sbjct: 1278 SNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQF 1337
Query: 1395 TDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM 1453
W + P S + F+ + +V K + + G DG VHC G GR+G F + VLE +
Sbjct: 1338 LRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMI 1396
Query: 1454 RYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1493
R +VD+F K LR +P MV+T D+Y FCY ALEYL
Sbjct: 1397 RCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1436
Score = 63.5 bits (153), Expect = 1e-09
Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)
Query: 296 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 351
Y CV+ + G + A++ VK P P + T + I ++ + P+
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Query: 352 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 409
IEY+ GP+ ++ Y + L P++EYEI V + G G P +++RT
Sbjct: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
Query: 410 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 469
P AP+ + + A + +QW EP+ N + R + ++ + +G+ + +
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437
Query: 470 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 522
+ T T+ +LL VR L T+ + +T + VP + AE+
Sbjct: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493
Query: 523 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 567
+ E I L W P++ + I +YE+ ++ + P T +V
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
Query: 568 VEDLKPNTEYAFRLAARSPQGLG 590
+L P T Y F + AR+ +G G
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFG 576
>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
precursor [Homo sapiens]
Length = 1446
Score = 445 bits (1145), Expect = e-124
Identities = 240/579 (41%), Positives = 340/579 (58%), Gaps = 17/579 (2%)
Query: 923 HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 982
HP + +AD+ +H ++K + QEYES G W+ + + +R + AYD
Sbjct: 871 HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYD 926
Query: 983 HSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVM 1042
RV L P+ G +DYINANY+DGY N +IATQGP PE DFWRMVW++ ++IVM
Sbjct: 927 RHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVM 986
Query: 1043 MTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1102
+T+L E R+KC +YWP ++TYG I++ L+ T LA + VRTF+L + G S + EVRQ
Sbjct: 987 ITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQ 1045
Query: 1103 FQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI 1162
F FTAWP+HGVP + T LAF+RRVK PPDAGPIV+HCSAG GRTGC+IV+D ML+
Sbjct: 1046 FHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMA 1105
Query: 1163 KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA 1222
+ E VD+Y V + S+R M+QTE+QY FIH+A+LEA CG T +P A +++
Sbjct: 1106 ECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMI 1165
Query: 1223 QVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1280
+++P + + + EF+ L A LP N+ KNR ++++P + CL +
Sbjct: 1166 RIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFL 1222
Query: 1281 RGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREM 1338
+G ++YINA+ D Y + A+I T PL TT DFWR++++ T +VML +L +
Sbjct: 1223 ISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQS 1282
Query: 1339 GRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFT 1395
C QYWP +Y V+ M+ + R F+V + Q VR FQF
Sbjct: 1283 NSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFL 1342
Query: 1396 DWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMR 1454
W + P S + F+ + +V K + + G DG VHC G GR+G F + VLE +R
Sbjct: 1343 RWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIR 1401
Query: 1455 YEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1493
+VD+F K LR +P MV+T D+Y FCY ALEYL
Sbjct: 1402 CHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1440
Score = 63.5 bits (153), Expect = 1e-09
Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)
Query: 296 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 351
Y CV+ + G + A++ VK P P + T + I ++ + P+
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Query: 352 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 409
IEY+ GP+ ++ Y + L P++EYEI V + G G P +++RT
Sbjct: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
Query: 410 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 469
P AP+ + + A + +QW EP+ N + R + ++ + +G+ + +
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437
Query: 470 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 522
+ T T+ +LL VR L T+ + +T + VP + AE+
Sbjct: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493
Query: 523 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 567
+ E I L W P++ + I +YE+ ++ + P T +V
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
Query: 568 VEDLKPNTEYAFRLAARSPQGLG 590
+L P T Y F + AR+ +G G
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFG 576
Score = 42.4 bits (98), Expect = 0.003
Identities = 91/381 (23%), Positives = 139/381 (36%), Gaps = 66/381 (17%)
Query: 481 DETYTVRVLAFTSVGDGPLS---DPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPR 536
D Y + VL T GDG P+ +T+ P + P L +TL W P
Sbjct: 350 DTEYEISVL-LTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLG 408
Query: 537 QESI----------IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSP 586
Y L RE +T + Y +++L P RL +P
Sbjct: 409 YNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNP 468
Query: 587 QGLGAFTPVVRQRTLQSISPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNG 641
+G V Q T + + P + + ++ + L WE P N T Y+I Y
Sbjct: 469 EGRKEGKEVTFQ-TDEDV-PSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQS 526
Query: 642 L-----TLDVDG--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTA 684
+ ++V G RT KL ++L P T Y F + T +G L + T
Sbjct: 527 IESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTN 586
Query: 685 WTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQF 738
+A + + +P +++ I V L Q P+ Y +++ LR+ GGQ
Sbjct: 587 ISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQD 645
Query: 739 LTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQ 796
P+ + L R L H E+ S LP F GD +
Sbjct: 646 CFPVPLTFEAALA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQT 687
Query: 797 YGGFDNRGLEPGHRYVLFVLA 817
Y GF N LEP Y+++ A
Sbjct: 688 YRGFWNPPLEPRKAYLIYFQA 708
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 412 bits (1058), Expect = e-114
Identities = 241/592 (40%), Positives = 336/592 (56%), Gaps = 24/592 (4%)
Query: 921 LSHPPIPIADMAEHTERLKANDSLK-LSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVI 979
+ H P +AD+ + + ++LK QE +S T + SN NK KNRY N++
Sbjct: 1701 IKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIV 1760
Query: 980 AYDHSRVILQPIEGIMG--SDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRS 1037
AYDHSRV L + G +DYINANYVDGY AYIA QGPL T DFWRM+WE
Sbjct: 1761 AYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNV 1820
Query: 1038 ATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLH----KNG 1093
IVM+T L EK R KCDQYWP G+E YG VT LA + VR F+L K G
Sbjct: 1821 EVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKG 1880
Query: 1094 SSEKRE----VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRT 1149
S + R V Q+ +T WPD GVPEY P L F+R+ GP+VVHCSAGVGRT
Sbjct: 1881 SQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRT 1940
Query: 1150 GCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1209
G +IV+D+ML++I+ E TV+++G + +RSQRNY+VQTE+QY FIH+ L+EA+ TEV
Sbjct: 1941 GTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV 2000
Query: 1210 PARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMP 1269
++AY+ L P T +E +F+ L+ S S + +A CN+ KNR +I+P
Sbjct: 2001 LDSHIHAYVNALLIPGPAGK-TKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIP 2059
Query: 1270 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIV 1329
E +RV + + G EG+DYINAS+I GY Q +I TQ PL T +DFWRM+W++N+ +V
Sbjct: 2060 VERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV 2118
Query: 1330 VMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE-----YNMPQYILREFKVTDARD 1383
VM+ + M ++ YWP + + F V MAE N + I+++F + +D
Sbjct: 2119 VMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQD 2177
Query: 1384 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVF 1443
VR FQ WP P S + I + +E +DGP+ VH G G F
Sbjct: 2178 DYVLEVRHFQCPKWPNPDSPISKT--FELISVI--KEEAANRDGPMIVHDEHGGVTAGTF 2233
Query: 1444 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1495
L+ ++ ++ E VD++Q KM+ RP + ++YQF Y+ L + +
Sbjct: 2234 CALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST 2285
Score = 117 bits (292), Expect = 1e-25
Identities = 79/278 (28%), Positives = 133/278 (47%), Gaps = 12/278 (4%)
Query: 945 KLSQEYESIDPG--QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINA 1002
KL ++++ + QQ + + + N+ KNR +++I + SRV + + G G+DYINA
Sbjct: 2022 KLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINA 2080
Query: 1003 NYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG 1062
+Y+ GY N +I TQ PL T DFWRM+W+ + +VM+ + + + YWPN+
Sbjct: 2081 SYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKD 2139
Query: 1063 TE-TYGFIQVTLLDTIELAT-----FCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEY 1116
+VTL+ ++ F L EVR FQ WP+ P
Sbjct: 2140 EPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPIS 2199
Query: 1117 PTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTL 1176
T L + + + N GP++VH G G F + ++ +++ E +VDVY +
Sbjct: 2200 KTFELISVIKEEAANRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKM 2257
Query: 1177 MRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSL 1214
+ R + +QY F+++ +L V E P+ SL
Sbjct: 2258 INLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSL 2295
Score = 33.1 bits (74), Expect = 2.1
Identities = 22/84 (26%), Positives = 41/84 (48%), Gaps = 9/84 (10%)
Query: 514 QPMNLRAEARSETSITLSWSPPR---QESIIKYELLFREGDHGREVGRTFDPTTSY---- 566
+P N++A+ + TS+ ++W PR I K+ +L+++ D + F T Y
Sbjct: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEF-LTDGYQDLG 372
Query: 567 -VVEDLKPNTEYAFRLAARSPQGL 589
++ +L PN Y ++ A GL
Sbjct: 373 AILNNLLPNMSYVLQIVAICTNGL 396
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
precursor [Homo sapiens]
Length = 1256
Score = 397 bits (1019), Expect = e-110
Identities = 235/598 (39%), Positives = 333/598 (55%), Gaps = 33/598 (5%)
Query: 920 MLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANV 978
+++ PI + E +R A++ E++SI +F + + N+ KNRY ++
Sbjct: 577 LMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDI 636
Query: 979 IAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSA 1038
+ YD++RV L I G GS+YINA+Y+DG++ YIA QGP ET DFWRM+WEQ++
Sbjct: 637 LPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKAT 696
Query: 1039 TIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNGSS 1095
IVM+TR EE +R KC +YWP+ GT +G + V + + ++ ++ +K +
Sbjct: 697 VIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA 756
Query: 1096 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1155
REV QFT+WPDHGVPE P L RRV + +GPIVVHCSAGVGRTG +I I
Sbjct: 757 TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGI 816
Query: 1156 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1215
DAMLE ++ E VDVYG+V +R QR MVQ E QY IH+AL+E G TEV L+
Sbjct: 817 DAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELH 876
Query: 1216 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1275
Y+ + + +P + +E EF+RL + ++ ++ I N NK KNR N++PY+ RV
Sbjct: 877 PYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRV 935
Query: 1276 CLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1316
L+ E S YINASFI Y + + IA QGPL ET D
Sbjct: 936 PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGD 995
Query: 1317 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1376
FW+M+++ ++VMLT+L+ +E C QYW E Y VD Y LR F
Sbjct: 996 FWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF 1054
Query: 1377 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------P 1428
++ ++ SRTV Q+Q+T+W + +P + I I V K ++ +G P
Sbjct: 1055 ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTP 1114
Query: 1429 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1486
+ +HC G +TG+F L +LE E VVDIFQ VK LR RP MV T ++YQF Y
Sbjct: 1115 LLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172
Score = 198 bits (503), Expect = 4e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 622 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681
Query: 1313 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1370
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 682 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741
Query: 1371 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1429
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 742 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799
Query: 1430 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1489
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E +Y +QA
Sbjct: 800 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
Query: 1490 LEY 1492
+EY
Sbjct: 860 VEY 862
Score = 155 bits (392), Expect = 3e-37
Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)
Query: 946 LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 989
L E++ + + + +H N E NK KNR +NVI YD++RV L+
Sbjct: 894 LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 953
Query: 990 ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1045
+ S YINA+++ Y IA QGPL ET GDFW+M+++++ IVM+T
Sbjct: 954 SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 1013
Query: 1046 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1105
L+ + C QYW G +TYG I+V L DT + +T+ +R F L + + R V Q+Q+
Sbjct: 1014 LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 1072
Query: 1106 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1155
T W +P P ++ ++ VK P + P+++HC G +TG F +
Sbjct: 1073 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1132
Query: 1156 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1209
+LE + E+ VD++ V +R R MV T +QY F+++ + N +V
Sbjct: 1133 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1186
Score = 32.3 bits (72), Expect = 3.5
Identities = 20/79 (25%), Positives = 38/79 (48%), Gaps = 2/79 (2%)
Query: 505 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 564
+KT G PG+P + + + ++W+PP Q S + L + + + ++
Sbjct: 335 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 392
Query: 565 SYVVEDLKPNTEYAFRLAA 583
Y +++LKP T+Y L A
Sbjct: 393 KYDLQNLKPYTKYVLSLHA 411
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
precursor [Homo sapiens]
Length = 1304
Score = 397 bits (1019), Expect = e-110
Identities = 235/598 (39%), Positives = 333/598 (55%), Gaps = 33/598 (5%)
Query: 920 MLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANV 978
+++ PI + E +R A++ E++SI +F + + N+ KNRY ++
Sbjct: 625 LMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDI 684
Query: 979 IAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSA 1038
+ YD++RV L I G GS+YINA+Y+DG++ YIA QGP ET DFWRM+WEQ++
Sbjct: 685 LPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKAT 744
Query: 1039 TIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNGSS 1095
IVM+TR EE +R KC +YWP+ GT +G + V + + ++ ++ +K +
Sbjct: 745 VIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA 804
Query: 1096 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1155
REV QFT+WPDHGVPE P L RRV + +GPIVVHCSAGVGRTG +I I
Sbjct: 805 TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGI 864
Query: 1156 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1215
DAMLE ++ E VDVYG+V +R QR MVQ E QY IH+AL+E G TEV L+
Sbjct: 865 DAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELH 924
Query: 1216 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1275
Y+ + + +P + +E EF+RL + ++ ++ I N NK KNR N++PY+ RV
Sbjct: 925 PYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRV 983
Query: 1276 CLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1316
L+ E S YINASFI Y + + IA QGPL ET D
Sbjct: 984 PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGD 1043
Query: 1317 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1376
FW+M+++ ++VMLT+L+ +E C QYW E Y VD Y LR F
Sbjct: 1044 FWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF 1102
Query: 1377 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------P 1428
++ ++ SRTV Q+Q+T+W + +P + I I V K ++ +G P
Sbjct: 1103 ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTP 1162
Query: 1429 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1486
+ +HC G +TG+F L +LE E VVDIFQ VK LR RP MV T ++YQF Y
Sbjct: 1163 LLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1220
Score = 198 bits (503), Expect = 4e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 670 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 729
Query: 1313 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1370
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 730 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 789
Query: 1371 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1429
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 790 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 847
Query: 1430 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1489
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E +Y +QA
Sbjct: 848 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907
Query: 1490 LEY 1492
+EY
Sbjct: 908 VEY 910
Score = 155 bits (392), Expect = 3e-37
Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)
Query: 946 LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 989
L E++ + + + +H N E NK KNR +NVI YD++RV L+
Sbjct: 942 LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 1001
Query: 990 ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1045
+ S YINA+++ Y IA QGPL ET GDFW+M+++++ IVM+T
Sbjct: 1002 SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 1061
Query: 1046 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1105
L+ + C QYW G +TYG I+V L DT + +T+ +R F L + + R V Q+Q+
Sbjct: 1062 LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 1120
Query: 1106 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1155
T W +P P ++ ++ VK P + P+++HC G +TG F +
Sbjct: 1121 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1180
Query: 1156 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1209
+LE + E+ VD++ V +R R MV T +QY F+++ + N +V
Sbjct: 1181 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1234
Score = 32.3 bits (72), Expect = 3.5
Identities = 20/79 (25%), Positives = 38/79 (48%), Gaps = 2/79 (2%)
Query: 505 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 564
+KT G PG+P + + + ++W+PP Q S + L + + + ++
Sbjct: 383 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 440
Query: 565 SYVVEDLKPNTEYAFRLAA 583
Y +++LKP T+Y L A
Sbjct: 441 KYDLQNLKPYTKYVLSLHA 459
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
precursor [Homo sapiens]
Length = 1143
Score = 397 bits (1019), Expect = e-110
Identities = 235/598 (39%), Positives = 333/598 (55%), Gaps = 33/598 (5%)
Query: 920 MLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANV 978
+++ PI + E +R A++ E++SI +F + + N+ KNRY ++
Sbjct: 464 LMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDI 523
Query: 979 IAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSA 1038
+ YD++RV L I G GS+YINA+Y+DG++ YIA QGP ET DFWRM+WEQ++
Sbjct: 524 LPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKAT 583
Query: 1039 TIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNGSS 1095
IVM+TR EE +R KC +YWP+ GT +G + V + + ++ ++ +K +
Sbjct: 584 VIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA 643
Query: 1096 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1155
REV QFT+WPDHGVPE P L RRV + +GPIVVHCSAGVGRTG +I I
Sbjct: 644 TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGI 703
Query: 1156 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1215
DAMLE ++ E VDVYG+V +R QR MVQ E QY IH+AL+E G TEV L+
Sbjct: 704 DAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELH 763
Query: 1216 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1275
Y+ + + +P + +E EF+RL + ++ ++ I N NK KNR N++PY+ RV
Sbjct: 764 PYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRV 822
Query: 1276 CLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1316
L+ E S YINASFI Y + + IA QGPL ET D
Sbjct: 823 PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGD 882
Query: 1317 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1376
FW+M+++ ++VMLT+L+ +E C QYW E Y VD Y LR F
Sbjct: 883 FWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF 941
Query: 1377 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------P 1428
++ ++ SRTV Q+Q+T+W + +P + I I V K ++ +G P
Sbjct: 942 ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTP 1001
Query: 1429 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1486
+ +HC G +TG+F L +LE E VVDIFQ VK LR RP MV T ++YQF Y
Sbjct: 1002 LLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059
Score = 198 bits (503), Expect = 4e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568
Query: 1313 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1370
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 569 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628
Query: 1371 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1429
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 629 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686
Query: 1430 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1489
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E +Y +QA
Sbjct: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
Query: 1490 LEY 1492
+EY
Sbjct: 747 VEY 749
Score = 155 bits (392), Expect = 3e-37
Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)
Query: 946 LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 989
L E++ + + + +H N E NK KNR +NVI YD++RV L+
Sbjct: 781 LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 840
Query: 990 ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1045
+ S YINA+++ Y IA QGPL ET GDFW+M+++++ IVM+T
Sbjct: 841 SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 900
Query: 1046 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1105
L+ + C QYW G +TYG I+V L DT + +T+ +R F L + + R V Q+Q+
Sbjct: 901 LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 959
Query: 1106 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1155
T W +P P ++ ++ VK P + P+++HC G +TG F +
Sbjct: 960 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1019
Query: 1156 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1209
+LE + E+ VD++ V +R R MV T +QY F+++ + N +V
Sbjct: 1020 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1073
Score = 32.3 bits (72), Expect = 3.5
Identities = 20/79 (25%), Positives = 38/79 (48%), Gaps = 2/79 (2%)
Query: 505 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 564
+KT G PG+P + + + ++W+PP Q S + L + + + ++
Sbjct: 222 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 279
Query: 565 SYVVEDLKPNTEYAFRLAA 583
Y +++LKP T+Y L A
Sbjct: 280 KYDLQNLKPYTKYVLSLHA 298
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,335,556
Number of Sequences: 37866
Number of extensions: 3068823
Number of successful extensions: 15800
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 325
Number of HSP's successfully gapped in prelim test: 214
Number of HSP's that attempted gapping in prelim test: 6394
Number of HSP's gapped (non-prelim): 3508
length of query: 1501
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1386
effective length of database: 13,892,928
effective search space: 19255598208
effective search space used: 19255598208
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.