Search of human proteins with 104487006

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
         (1948 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...  3959   0.0  
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...  3846   0.0  
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...  2836   0.0  
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...  2814   0.0  
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...  2806   0.0  
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...  2555   0.0  
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...  2538   0.0  
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...  1897   0.0  
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...  1897   0.0  
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...  1504   0.0  
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo...  1492   0.0  
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor...   588   e-167
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo...   587   e-167
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo...   587   e-167
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor...   549   e-156
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo...   549   e-155
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo...   516   e-146
gi|208431815 protein tyrosine phosphatase, receptor type, K isof...   510   e-144
gi|157419150 protein tyrosine phosphatase, receptor type, M isof...   505   e-142
gi|157419152 protein tyrosine phosphatase, receptor type, M isof...   497   e-140
gi|148539860 protein tyrosine phosphatase, receptor type, T isof...   476   e-134
gi|148539858 protein tyrosine phosphatase, receptor type, T isof...   468   e-131
gi|110735404 protein tyrosine phosphatase, receptor type, U isof...   460   e-129
gi|194097398 protein tyrosine phosphatase, receptor type, G prec...   455   e-127
gi|110735406 protein tyrosine phosphatase, receptor type, U isof...   454   e-127
gi|110735402 protein tyrosine phosphatase, receptor type, U isof...   453   e-127
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p...   412   e-114
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo...   397   e-110
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo...   397   e-110
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo...   397   e-110

>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score = 3959 bits (10266), Expect = 0.0
 Identities = 1948/1948 (100%), Positives = 1948/1948 (100%)

Query: 1    MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
            MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP
Sbjct: 1    MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60

Query: 61   KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
            KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA
Sbjct: 61   KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120

Query: 121  KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
            KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS
Sbjct: 121  KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180

Query: 181  NGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREV 240
            NGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREV
Sbjct: 181  NGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREV 240

Query: 241  RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL 300
            RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL
Sbjct: 241  RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL 300

Query: 301  TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV 360
            TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV
Sbjct: 301  TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV 360

Query: 361  SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR 420
            SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR
Sbjct: 361  SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR 420

Query: 421  TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 480
            TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV
Sbjct: 421  TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 480

Query: 481  DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 540
            DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS
Sbjct: 481  DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 540

Query: 541  ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 600
            ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ
Sbjct: 541  ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 600

Query: 601  GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRP 660
            GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRP
Sbjct: 601  GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRP 660

Query: 661  LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 720
            LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP
Sbjct: 661  LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 720

Query: 721  SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 780
            SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA
Sbjct: 721  SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 780

Query: 781  DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 840
            DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV
Sbjct: 781  DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 840

Query: 841  QQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGAT 900
            QQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGAT
Sbjct: 841  QQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGAT 900

Query: 901  YVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNG 960
            YVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNG
Sbjct: 901  YVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNG 960

Query: 961  AIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGP 1020
            AIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGP
Sbjct: 961  AIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGP 1020

Query: 1021 FSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGR 1080
            FSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGR
Sbjct: 1021 FSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGR 1080

Query: 1081 TTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMV 1140
            TTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMV
Sbjct: 1081 TTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMV 1140

Query: 1141 YLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSR 1200
            YLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSR
Sbjct: 1141 YLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSR 1200

Query: 1201 QLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAAS 1260
            QLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAAS
Sbjct: 1201 QLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAAS 1260

Query: 1261 PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR 1320
            PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR
Sbjct: 1261 PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR 1320

Query: 1321 TKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAE 1380
            TKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAE
Sbjct: 1321 TKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAE 1380

Query: 1381 HTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG 1440
            HTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG
Sbjct: 1381 HTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG 1440

Query: 1441 IMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIK 1500
            IMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIK
Sbjct: 1441 IMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIK 1500

Query: 1501 CDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV 1560
            CDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV
Sbjct: 1501 CDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV 1560

Query: 1561 PEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGH 1620
            PEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGH
Sbjct: 1561 PEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGH 1620

Query: 1621 VTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGM 1680
            VTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGM
Sbjct: 1621 VTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGM 1680

Query: 1681 ELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASF 1740
            ELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASF
Sbjct: 1681 ELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASF 1740

Query: 1741 IDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSA 1800
            IDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSA
Sbjct: 1741 IDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSA 1800

Query: 1801 RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI 1860
            RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI
Sbjct: 1801 RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI 1860

Query: 1861 GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRP 1920
            GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRP
Sbjct: 1861 GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRP 1920

Query: 1921 AMVQTEDEYQFCYQAALEYLGSFDHYAT 1948
            AMVQTEDEYQFCYQAALEYLGSFDHYAT
Sbjct: 1921 AMVQTEDEYQFCYQAALEYLGSFDHYAT 1948


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score = 3846 bits (9973), Expect = 0.0
 Identities = 1909/1948 (97%), Positives = 1909/1948 (97%), Gaps = 38/1948 (1%)

Query: 1    MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
            MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP
Sbjct: 1    MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60

Query: 61   KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
            KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA
Sbjct: 61   KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120

Query: 121  KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
            KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS
Sbjct: 121  KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180

Query: 181  NGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREV 240
            NGRIKQLRS         GALQIESSEETDQGKYECVATNSAGVRYSSPANLYVR    V
Sbjct: 181  NGRIKQLRS---------GALQIESSEETDQGKYECVATNSAGVRYSSPANLYVR----V 227

Query: 241  RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL 300
            RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL
Sbjct: 228  RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL 287

Query: 301  TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV 360
            TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV
Sbjct: 288  TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV 347

Query: 361  SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR 420
            SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR
Sbjct: 348  SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR 407

Query: 421  TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 480
            TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV
Sbjct: 408  TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 467

Query: 481  DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 540
            DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS
Sbjct: 468  DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 527

Query: 541  ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 600
            ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ
Sbjct: 528  ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 587

Query: 601  GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRP 660
            GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRP
Sbjct: 588  GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRP 647

Query: 661  LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 720
            LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP
Sbjct: 648  LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 707

Query: 721  SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 780
            SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA
Sbjct: 708  SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 767

Query: 781  DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 840
            DAQ         EMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV
Sbjct: 768  DAQ---------EMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 818

Query: 841  QQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGAT 900
            QQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGAT
Sbjct: 819  QQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGAT 878

Query: 901  YVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNG 960
            YVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNG
Sbjct: 879  YVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNG 938

Query: 961  AIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGP 1020
            AIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGP
Sbjct: 939  AIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGP 998

Query: 1021 FSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGR 1080
            FSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGR
Sbjct: 999  FSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGR 1058

Query: 1081 TTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMV 1140
            TTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMV
Sbjct: 1059 TTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMV 1118

Query: 1141 YLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSR 1200
            YLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSR
Sbjct: 1119 YLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSR 1178

Query: 1201 QLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAAS 1260
            QLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAAS
Sbjct: 1179 QLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAAS 1238

Query: 1261 PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR 1320
            PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR
Sbjct: 1239 PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR 1298

Query: 1321 TKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAE 1380
            TKCLLNNADLAPHHPKDPVEMRRINFQTP                 MLSHPPIPIADMAE
Sbjct: 1299 TKCLLNNADLAPHHPKDPVEMRRINFQTP----------------GMLSHPPIPIADMAE 1342

Query: 1381 HTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG 1440
            HTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG
Sbjct: 1343 HTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG 1402

Query: 1441 IMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIK 1500
            IMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIK
Sbjct: 1403 IMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIK 1462

Query: 1501 CDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV 1560
            CDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV
Sbjct: 1463 CDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV 1522

Query: 1561 PEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGH 1620
            PEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGH
Sbjct: 1523 PEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGH 1582

Query: 1621 VTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGM 1680
            VTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGM
Sbjct: 1583 VTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGM 1642

Query: 1681 ELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASF 1740
            ELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASF
Sbjct: 1643 ELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASF 1702

Query: 1741 IDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSA 1800
            IDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSA
Sbjct: 1703 IDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSA 1762

Query: 1801 RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI 1860
            RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI
Sbjct: 1763 RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI 1822

Query: 1861 GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRP 1920
            GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRP
Sbjct: 1823 GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRP 1882

Query: 1921 AMVQTEDEYQFCYQAALEYLGSFDHYAT 1948
            AMVQTEDEYQFCYQAALEYLGSFDHYAT
Sbjct: 1883 AMVQTEDEYQFCYQAALEYLGSFDHYAT 1910


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score = 2836 bits (7353), Expect = 0.0
 Identities = 1387/1924 (72%), Positives = 1609/1924 (83%), Gaps = 35/1924 (1%)

Query: 29   AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
            AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20   AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79

Query: 89   AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
            +VLRIQPLRTPRDE +YECVA N+VGEI+V  +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80   SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139

Query: 149  TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEE 208
            TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRSE+   TPIRGALQIE SEE
Sbjct: 140  TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199

Query: 209  TDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVA 268
            +DQGKYECVATNSAG RYS+PANLYVRELREVRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200  SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259

Query: 269  VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 328
            VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 260  VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319

Query: 329  KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 388
            K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ +  Y+  + + TTRYS
Sbjct: 320  KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379

Query: 389  IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 448
            + GLSP S+YE  V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 380  VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439

Query: 449  EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 508
            EP EPNG I+GYRVYYTM+P   V NW KHNV DS +TT+G+L+  +TY+V+VLAFTS+G
Sbjct: 440  EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499

Query: 509  DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 568
            DGPLS  IQV TQ GVPGQP+N +AE  SETSI LSW+PPR ++I  YEL++++G+HG E
Sbjct: 500  DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559

Query: 569  VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 628
               T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T  +  RT+QSKPSAPPQD+ C 
Sbjct: 560  QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619

Query: 629  SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 688
            S  ST+ILVSW+PPP E  NG +  YS++Y  +  ED +P E+ GIP  TT+ LLE LEK
Sbjct: 620  SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679

Query: 689  WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 748
            WT+YRIT  AHT+VGPGPES  V++RT+EDVPS PPRKVE EA+N+T+++V WRSP P +
Sbjct: 680  WTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK 739

Query: 749  QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSIT 808
            QHGQIRGYQVHYVRME  E +G P +KDVMLADAQWE DDT E++M+I+ LQPET+YS+T
Sbjct: 740  QHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLT 799

Query: 809  VAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRL 868
            V AYT KGDGARSKPK+V T GAV G+P L +  T   + L +W PP  T    + GYRL
Sbjct: 800  VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTF-GPLQGYRL 858

Query: 869  QFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTP 928
            +FGR+D  PL TLEF   ED +TA+ +HKGA+YVFRL+AR++ G GEE  + +SIPE+ P
Sbjct: 859  KFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVP 918

Query: 929  RGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAG-ALGPARETELPAAA 987
             G PQ L + G  S  +V L W PPV AERNG I KYT+  R+    L P  +  +P   
Sbjct: 919  TGFPQNLHSEGTTST-SVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVP--- 974

Query: 988  EPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMK 1047
               A+  +TL GLKPDT YD++VRAHT +GPGP+SP V++RT   DQV  KNF VK +MK
Sbjct: 975  ---ADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMK 1031

Query: 1048 TSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSS 1105
            TSVLLSWE P+NYNS  P+KI Y+   +  +VDGR T+KLI +LKP   Y+FVLTNRG+S
Sbjct: 1032 TSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNS 1091

Query: 1106 LGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSR 1165
             GGLQ  VTA TA ++L  KP+   K + DG I V LP+  +   ++ Y+I++VPL+KSR
Sbjct: 1092 AGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSR 1151

Query: 1166 GGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQ 1225
             G+F+ P  SP++M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP  F  GD 
Sbjct: 1152 -GKFIKPWESPDEMELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDD 1208

Query: 1226 KQYGGFDNRGLEPGHRYVLFVLAVLQKSE-PTFAASPFSDPFQLDNPDPQPIVDGEEGLI 1284
            K YGGF N+ L+ G  YV FVLAV++ +E   +A SP+SDP    + DPQPI D EEGLI
Sbjct: 1209 KHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLI 1268

Query: 1285 WVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRI 1344
            WV+GPVLAVVFIICIVIAILLYK     KR +S+ R   + NN ++  HHP DPVE+RR+
Sbjct: 1269 WVVGPVLAVVFIICIVIAILLYKR----KRAESDSRKSSIPNNKEIPSHHPTDPVELRRL 1324

Query: 1345 NFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ 1404
            NFQTP                 M SHPPIPI ++A+H ERLKAND+LK SQEYESIDPGQ
Sbjct: 1325 NFQTP----------------GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ 1368

Query: 1405 QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIAT 1464
            QFTWEHSNLEVNKPKNRYANVIAYDHSRV+L  IEGI GSDY+NANY+DGYR QNAYIAT
Sbjct: 1369 QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIAT 1428

Query: 1465 QGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTI 1524
            QG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QVTLLDT+
Sbjct: 1429 QGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTV 1488

Query: 1525 ELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGP 1584
            ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP
Sbjct: 1489 ELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGP 1548

Query: 1585 IVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEA 1644
            +VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY FIH+A
Sbjct: 1549 MVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDA 1608

Query: 1645 LLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPC 1704
            LLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFISANLPC
Sbjct: 1609 LLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPC 1668

Query: 1705 NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF 1764
            NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF
Sbjct: 1669 NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF 1728

Query: 1765 WRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFK 1824
            WRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFK
Sbjct: 1729 WRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFK 1788

Query: 1825 VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV 1884
            VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV
Sbjct: 1789 VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV 1848

Query: 1885 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFD 1944
            GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALEYLGSFD
Sbjct: 1849 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFD 1908

Query: 1945 HYAT 1948
            HYAT
Sbjct: 1909 HYAT 1912



 Score =  183 bits (465), Expect = 1e-45
 Identities = 218/906 (24%), Positives = 355/906 (39%), Gaps = 133/906 (14%)

Query: 237  LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 288
            LR      PRF+  P+    + GG  +  C A G P P + W         Q  E +  +
Sbjct: 16   LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75

Query: 289  DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 339
            D       +  L   +D A Y CVA +++G I    ++TV    + P G P         
Sbjct: 76   DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135

Query: 340  VTENTATSITITWDSGNPDP-VSYY--------------------------------VIE 366
            V E T T+  +   SGNPDP ++++                                 IE
Sbjct: 136  VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIE 195

Query: 367  YKSKSQDGPYQ-IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQA 425
               +S  G Y+ +  +   TRYS       +   ++V  +  + + PP  S+     E  
Sbjct: 196  QSEESDQGKYECVATNSAGTRYS-------APANLYVRELREVRRVPPRFSIPPTNHEIM 248

Query: 426  PASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLL 485
            P  +  N+    + +    V+W    E            T E + P+G     NV     
Sbjct: 249  PGGSV-NITCVAVGSPMPYVKWMLGAED----------LTPEDDMPIG----RNV----- 288

Query: 486  TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSW 545
              +  + +   YT   +A +++G       I VK     PG P+   + A   TSITL+W
Sbjct: 289  LELNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTW 343

Query: 546  SPPRQESIIKYELLFREGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLG 603
                 E  + Y ++  +  +  E+ +  D   TT Y V  L P ++Y FR+ A +  G G
Sbjct: 344  DSGNPEP-VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRG 402

Query: 604  AFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGS 663
              +  V  +T +  PS+ P+DV+   + ST ILV W+   PE  NG + GY V Y    +
Sbjct: 403  PPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYY----T 456

Query: 664  EDPEPKEVNGIPPTTTQILLEA---LEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 720
             DP     N +        +     L     Y +  +A T +G GP SS + V T   VP
Sbjct: 457  MDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP 516

Query: 721  SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 780
               P   +AE  + T+I + W  P    +   I  Y++ Y   E  E             
Sbjct: 517  -GQPLNFKAEPESETSILLSWTPP----RSDTIANYELVYKDGEHGE------------- 558

Query: 781  DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 840
            + +   +    Y   +  L+P + Y   +AA + +G GA +      T  +    P   +
Sbjct: 559  EQRITIEPGTSYR--LQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDI 616

Query: 841  QQTPEG--SLLARWEPPAGTAEDQVL-GYRLQF---GREDSTPLATLEFPPSEDRYTASG 894
              T     S+L  W+PP    ++ ++  Y +++     ED  P   L  P    +Y    
Sbjct: 617  SCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQ 676

Query: 895  VHKGATYVFRLAARSRGGLGEEAAEVL-SIPEDTPRGHPQILEAAGNASAGTVLLRWLPP 953
            + K   Y   + A +  G G E+  VL    ED P G P+ +E     ++ +V + W  P
Sbjct: 677  LEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEA-VNSTSVKVSWRSP 735

Query: 954  VPAERNGAIVKYTVAVREAGALGPARETELPAAA--------EPGAENALTLQGLKPDTA 1005
            VP +++G I  Y V         P  +  L            +   E+ + + GL+P+T+
Sbjct: 736  VPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETS 795

Query: 1006 YDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFP-DNYNSPT 1064
            Y L V A+T +G G  S P    T       P+   +      + L+ W  P D +    
Sbjct: 796  YSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPR-LVINHTQMNTALIQWHPPVDTFGPLQ 854

Query: 1065 PYKIQY 1070
             Y++++
Sbjct: 855  GYRLKF 860


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
            precursor [Homo sapiens]
          Length = 1903

 Score = 2814 bits (7295), Expect = 0.0
 Identities = 1381/1924 (71%), Positives = 1602/1924 (83%), Gaps = 44/1924 (2%)

Query: 29   AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
            AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20   AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79

Query: 89   AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
            +VLRIQPLRTPRDE +YECVA N+VGEI+V  +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80   SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139

Query: 149  TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEE 208
            TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRSE+   TPIRGALQIE SEE
Sbjct: 140  TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199

Query: 209  TDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVA 268
            +DQGKYECVATNSAG RYS+PANLYVRELREVRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200  SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259

Query: 269  VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 328
            VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 260  VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319

Query: 329  KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 388
            K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ +  Y+  + + TTRYS
Sbjct: 320  KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379

Query: 389  IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 448
            + GLSP S+YE  V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 380  VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439

Query: 449  EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 508
            EP EPNG I+GYRVYYTM+P   V NW KHNV DS +TT+G+L+  +TY+V+VLAFTS+G
Sbjct: 440  EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499

Query: 509  DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 568
            DGPLS  IQV TQ GVPGQP+N +AE  SETSI LSW+PPR ++I  YEL++++G+HG E
Sbjct: 500  DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559

Query: 569  VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 628
               T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T  +  RT+QSKPSAPPQD+ C 
Sbjct: 560  QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619

Query: 629  SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 688
            S  ST+ILVSW+PPP E  NG +  YS++Y  +  ED +P E+ GIP  TT+ LLE LEK
Sbjct: 620  SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679

Query: 689  WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 748
            WT+YRIT  AHT+VGPGPES  V++RT+EDVPS PPRKVE EA+N+T+++V WRSP P +
Sbjct: 680  WTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK 739

Query: 749  QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSIT 808
            QHGQIRGYQVHYVRME  E +G P +KDVMLADAQ         +M+I+ LQPET+YS+T
Sbjct: 740  QHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ---------DMIISGLQPETSYSLT 790

Query: 809  VAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRL 868
            V AYT KGDGARSKPK+V T GAV G+P L +  T   + L +W PP  T    + GYRL
Sbjct: 791  VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTF-GPLQGYRL 849

Query: 869  QFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTP 928
            +FGR+D  PL TLEF   ED +TA+ +HKGA+YVFRL+AR++ G GEE  + +SIPE+ P
Sbjct: 850  KFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVP 909

Query: 929  RGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAG-ALGPARETELPAAA 987
             G PQ L + G  S  +V L W PPV AERNG I KYT+  R+    L P  +  +P   
Sbjct: 910  TGFPQNLHSEGTTST-SVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVP--- 965

Query: 988  EPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMK 1047
               A+  +TL GLKPDT YD++VRAHT +GPGP+SP V++RT   DQV  KNF VK +MK
Sbjct: 966  ---ADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMK 1022

Query: 1048 TSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSS 1105
            TSVLLSWE P+NYNS  P+KI Y+   +  +VDGR T+KLI +LKP   Y+FVLTNRG+S
Sbjct: 1023 TSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNS 1082

Query: 1106 LGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSR 1165
             GGLQ  VTA TA ++L  KP+   K + DG I V LP+  +   ++ Y+I++VPL+KSR
Sbjct: 1083 AGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSR 1142

Query: 1166 GGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQ 1225
             G+F+ P  SP++M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP  F  GD 
Sbjct: 1143 -GKFIKPWESPDEMELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDD 1199

Query: 1226 KQYGGFDNRGLEPGHRYVLFVLAVLQKSE-PTFAASPFSDPFQLDNPDPQPIVDGEEGLI 1284
            K YGGF N+ L+ G  YV FVLAV++ +E   +A SP+SDP    + DPQPI D EEGLI
Sbjct: 1200 KHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLI 1259

Query: 1285 WVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRI 1344
            WV+GPVLAVVFIICIVIAILLYK     KR +S+ R   + NN ++  HHP DPVE+RR+
Sbjct: 1260 WVVGPVLAVVFIICIVIAILLYKR----KRAESDSRKSSIPNNKEIPSHHPTDPVELRRL 1315

Query: 1345 NFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ 1404
            NFQTP                 M SHPPIPI ++A+H ERLKAND+LK SQEYESIDPGQ
Sbjct: 1316 NFQTP----------------GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ 1359

Query: 1405 QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIAT 1464
            QFTWEHSNLEVNKPKNRYANVIAYDHSRV+L  IEGI GSDY+NANY+DGYR QNAYIAT
Sbjct: 1360 QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIAT 1419

Query: 1465 QGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTI 1524
            QG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QVTLLDT+
Sbjct: 1420 QGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTV 1479

Query: 1525 ELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGP 1584
            ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP
Sbjct: 1480 ELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGP 1539

Query: 1585 IVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEA 1644
            +VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY FIH+A
Sbjct: 1540 MVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDA 1599

Query: 1645 LLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPC 1704
            LLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFISANLPC
Sbjct: 1600 LLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPC 1659

Query: 1705 NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF 1764
            NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF
Sbjct: 1660 NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF 1719

Query: 1765 WRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFK 1824
            WRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFK
Sbjct: 1720 WRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFK 1779

Query: 1825 VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV 1884
            VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV
Sbjct: 1780 VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV 1839

Query: 1885 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFD 1944
            GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALEYLGSFD
Sbjct: 1840 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFD 1899

Query: 1945 HYAT 1948
            HYAT
Sbjct: 1900 HYAT 1903



 Score =  186 bits (471), Expect = 3e-46
 Identities = 218/898 (24%), Positives = 355/898 (39%), Gaps = 126/898 (14%)

Query: 237  LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 288
            LR      PRF+  P+    + GG  +  C A G P P + W         Q  E +  +
Sbjct: 16   LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75

Query: 289  DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 339
            D       +  L   +D A Y CVA +++G I    ++TV    + P G P         
Sbjct: 76   DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135

Query: 340  VTENTATSITITWDSGNPDP-VSYY--------------------------------VIE 366
            V E T T+  +   SGNPDP ++++                                 IE
Sbjct: 136  VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIE 195

Query: 367  YKSKSQDGPYQ-IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQA 425
               +S  G Y+ +  +   TRYS       +   ++V  +  + + PP  S+     E  
Sbjct: 196  QSEESDQGKYECVATNSAGTRYS-------APANLYVRELREVRRVPPRFSIPPTNHEIM 248

Query: 426  PASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLL 485
            P  +  N+    + +    V+W    E            T E + P+G     NV     
Sbjct: 249  PGGSV-NITCVAVGSPMPYVKWMLGAED----------LTPEDDMPIG----RNV----- 288

Query: 486  TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSW 545
              +  + +   YT   +A +++G       I VK     PG P+   + A   TSITL+W
Sbjct: 289  LELNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTW 343

Query: 546  SPPRQESIIKYELLFREGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLG 603
                 E  + Y ++  +  +  E+ +  D   TT Y V  L P ++Y FR+ A +  G G
Sbjct: 344  DSGNPEP-VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRG 402

Query: 604  AFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGS 663
              +  V  +T +  PS+ P+DV+   + ST ILV W+   PE  NG + GY V Y    +
Sbjct: 403  PPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYY----T 456

Query: 664  EDPEPKEVNGIPPTTTQILLEA---LEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 720
             DP     N +        +     L     Y +  +A T +G GP SS + V T   VP
Sbjct: 457  MDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP 516

Query: 721  SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 780
               P   +AE  + T+I + W  P    +   I  Y++ Y   E  E             
Sbjct: 517  -GQPLNFKAEPESETSILLSWTPP----RSDTIANYELVYKDGEHGE------------- 558

Query: 781  DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 840
            + +   +    Y   +  L+P + Y   +AA + +G GA +      T  +    P   +
Sbjct: 559  EQRITIEPGTSYR--LQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDI 616

Query: 841  QQTPEG--SLLARWEPPAGTAEDQVL-GYRLQF---GREDSTPLATLEFPPSEDRYTASG 894
              T     S+L  W+PP    ++ ++  Y +++     ED  P   L  P    +Y    
Sbjct: 617  SCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQ 676

Query: 895  VHKGATYVFRLAARSRGGLGEEAAEVL-SIPEDTPRGHPQILEAAGNASAGTVLLRWLPP 953
            + K   Y   + A +  G G E+  VL    ED P G P+ +E     ++ +V + W  P
Sbjct: 677  LEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEA-VNSTSVKVSWRSP 735

Query: 954  VPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAH 1013
            VP +++G I  Y V         P  +  L       A++ + + GL+P+T+Y L V A+
Sbjct: 736  VPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQD-MIISGLQPETSYSLTVTAY 794

Query: 1014 TRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFP-DNYNSPTPYKIQY 1070
            T +G G  S P    T       P+   +      + L+ W  P D +     Y++++
Sbjct: 795  TTKGDGARSKPKLVSTTGAVPGKPR-LVINHTQMNTALIQWHPPVDTFGPLQGYRLKF 851


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score = 2806 bits (7274), Expect = 0.0
 Identities = 1378/1924 (71%), Positives = 1599/1924 (83%), Gaps = 48/1924 (2%)

Query: 29   AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
            AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20   AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79

Query: 89   AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
            +VLRIQPLRTPRDE +YECVA N+VGEI+V  +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80   SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139

Query: 149  TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEE 208
            TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS         GALQIE SEE
Sbjct: 140  TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS---------GALQIEQSEE 190

Query: 209  TDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVA 268
            +DQGKYECVATNSAG RYS+PANLYVR    VRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 191  SDQGKYECVATNSAGTRYSAPANLYVR----VRRVPPRFSIPPTNHEIMPGGSVNITCVA 246

Query: 269  VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 328
            VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 247  VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 306

Query: 329  KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 388
            K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ +  Y+  + + TTRYS
Sbjct: 307  KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 366

Query: 389  IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 448
            + GLSP S+YE  V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 367  VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 426

Query: 449  EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 508
            EP EPNG I+GYRVYYTM+P   V NW KHNV DS +TT+G+L+  +TY+V+VLAFTS+G
Sbjct: 427  EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 486

Query: 509  DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 568
            DGPLS  IQV TQ GVPGQP+N +AE  SETSI LSW+PPR ++I  YEL++++G+HG E
Sbjct: 487  DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 546

Query: 569  VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 628
               T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T  +  RT+QSKPSAPPQD+ C 
Sbjct: 547  QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 606

Query: 629  SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 688
            S  ST+ILVSW+PPP E  NG +  YS++Y  +  ED +P E+ GIP  TT+ LLE LEK
Sbjct: 607  SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 666

Query: 689  WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 748
            WT+YRIT  AHT+VGPGPES  V++RT+EDVPS PPRKVE EA+N+T+++V WRSP P +
Sbjct: 667  WTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK 726

Query: 749  QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSIT 808
            QHGQIRGYQVHYVRME  E +G P +KDVMLADAQWE DDT E++M+I+ LQPET+YS+T
Sbjct: 727  QHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLT 786

Query: 809  VAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRL 868
            V AYT KGDGARSKPK+V T GAV G+P L +  T   + L +W PP  T    + GYRL
Sbjct: 787  VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTF-GPLQGYRL 845

Query: 869  QFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTP 928
            +FGR+D  PL TLEF   ED +TA+ +HKGA+YVFRL+AR++ G GEE  + +SIPE+ P
Sbjct: 846  KFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVP 905

Query: 929  RGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGA-LGPARETELPAAA 987
             G PQ L + G  S  +V L W PPV AERNG I KYT+  R+    L P  +  +PA  
Sbjct: 906  TGFPQNLHSEGTTST-SVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPA-- 962

Query: 988  EPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMK 1047
                +  +TL GLKPDT YD++VRAHT +GPGP+SP V++RT   DQV  KNF VK +MK
Sbjct: 963  ----DTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMK 1018

Query: 1048 TSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSS 1105
            TSVLLSWE P+NYNS  P+KI Y+   +  +VDGR T+KLI +LKP   Y+FVLTNRG+S
Sbjct: 1019 TSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNS 1078

Query: 1106 LGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSR 1165
             GGLQ  VTA TA ++L  KP+   K + DG I V LP+  +   ++ Y+I++VPL+KSR
Sbjct: 1079 AGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSR 1138

Query: 1166 GGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQ 1225
            G +F+ P  SP++M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP  F  GD 
Sbjct: 1139 G-KFIKPWESPDEMELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDD 1195

Query: 1226 KQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLI 1284
            K YGGF N+ L+ G  YV FVLAV++ +E   +A SP+SDP    + DPQPI D EEGLI
Sbjct: 1196 KHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLI 1255

Query: 1285 WVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRI 1344
            WV+GPVLAVVFIICIVIAILLYK K    R +S+ R   + NN ++  HHP DPVE+RR+
Sbjct: 1256 WVVGPVLAVVFIICIVIAILLYKRK----RAESDSRKSSIPNNKEIPSHHPTDPVELRRL 1311

Query: 1345 NFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ 1404
            NFQTP                 M SHPPIPI ++A+H ERLKAND+LK SQEYESIDPGQ
Sbjct: 1312 NFQTP----------------GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ 1355

Query: 1405 QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIAT 1464
            QFTWEHSNLEVNKPKNRYANVIAYDHSRV+L  IEGI GSDY+NANY+DGYR QNAYIAT
Sbjct: 1356 QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIAT 1415

Query: 1465 QGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTI 1524
            QG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QVTLLDT+
Sbjct: 1416 QGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTV 1475

Query: 1525 ELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGP 1584
            ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP
Sbjct: 1476 ELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGP 1535

Query: 1585 IVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEA 1644
            +VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY FIH+A
Sbjct: 1536 MVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDA 1595

Query: 1645 LLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPC 1704
            LLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFISANLPC
Sbjct: 1596 LLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPC 1655

Query: 1705 NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF 1764
            NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF
Sbjct: 1656 NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF 1715

Query: 1765 WRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFK 1824
            WRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFK
Sbjct: 1716 WRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFK 1775

Query: 1825 VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV 1884
            VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV
Sbjct: 1776 VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV 1835

Query: 1885 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFD 1944
            GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALEYLGSFD
Sbjct: 1836 GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFD 1895

Query: 1945 HYAT 1948
            HYAT
Sbjct: 1896 HYAT 1899



 Score =  182 bits (463), Expect = 2e-45
 Identities = 215/886 (24%), Positives = 351/886 (39%), Gaps = 106/886 (11%)

Query: 237  LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 288
            LR      PRF+  P+    + GG  +  C A G P P + W         Q  E +  +
Sbjct: 16   LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75

Query: 289  DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 339
            D       +  L   +D A Y CVA +++G I    ++TV    + P G P         
Sbjct: 76   DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135

Query: 340  VTENTATSITITWDSGNPDPVSYYVIEYK-----------SKSQDGPYQIK--EDITTTR 386
            V E T T+  +   SGNPDP   +  ++             + + G  QI+  E+    +
Sbjct: 136  VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGK 195

Query: 387  YS-IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIV 445
            Y  +   S  + Y    +    + + PP  S+     E  P  +  N+    + +    V
Sbjct: 196  YECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSV-NITCVAVGSPMPYV 254

Query: 446  QWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFT 505
            +W    E            T E + P+G     NV       +  + +   YT   +A +
Sbjct: 255  KWMLGAED----------LTPEDDMPIG----RNV-----LELNDVRQSANYT--CVAMS 293

Query: 506  SVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDH 565
            ++G       I VK     PG P+   + A   TSITL+W     E  + Y ++  +  +
Sbjct: 294  TLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTWDSGNPEP-VSYYIIQHKPKN 349

Query: 566  GREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQ 623
              E+ +  D   TT Y V  L P ++Y FR+ A +  G G  +  V  +T +  PS+ P+
Sbjct: 350  SEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPR 409

Query: 624  DVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILL 683
            DV+   + ST ILV W+   PE  NG + GY V Y    + DP     N +        +
Sbjct: 410  DVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYY----TMDPTQHVNNWMKHNVADSQI 463

Query: 684  EA---LEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVL 740
                 L     Y +  +A T +G GP SS + V T   VP   P   +AE  + T+I + 
Sbjct: 464  TTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP-GQPLNFKAEPESETSILLS 522

Query: 741  WRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQ 800
            W  P    +   I  Y++ Y   E  E             + +   +    Y   +  L+
Sbjct: 523  WTPP----RSDTIANYELVYKDGEHGE-------------EQRITIEPGTSYR--LQGLK 563

Query: 801  PETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEG--SLLARWEPPAGT 858
            P + Y   +AA + +G GA +      T  +    P   +  T     S+L  W+PP   
Sbjct: 564  PNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVE 623

Query: 859  AEDQVL-GYRLQF---GREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLG 914
             ++ ++  Y +++     ED  P   L  P    +Y    + K   Y   + A +  G G
Sbjct: 624  KQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG 683

Query: 915  EEAAEVL-SIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAG 973
             E+  VL    ED P G P+ +E     ++ +V + W  PVP +++G I  Y V      
Sbjct: 684  PESLSVLIRTNEDVPSGPPRKVEVEA-VNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRME 742

Query: 974  ALGPARETELPAAA--------EPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPV 1025
               P  +  L            +   E+ + + GL+P+T+Y L V A+T +G G  S P 
Sbjct: 743  NGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPK 802

Query: 1026 RYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFP-DNYNSPTPYKIQY 1070
               T       P+   +      + L+ W  P D +     Y++++
Sbjct: 803  LVSTTGAVPGKPR-LVINHTQMNTALIQWHPPVDTFGPLQGYRLKF 847


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score = 2555 bits (6621), Expect = 0.0
 Identities = 1302/1956 (66%), Positives = 1505/1956 (76%), Gaps = 57/1956 (2%)

Query: 1    MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
            MAP   PG   V     L+++ LV G   +  P FIK P+DQ G+SGGVASFVCQATG+P
Sbjct: 1    MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60

Query: 61   KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
            KPR+TW KKGKKV+SQRFE IEFD+ AG+VLRIQPLR  RDE +YEC A NS+GEI   A
Sbjct: 61   KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120

Query: 121  KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
            KL+VL E+QLP GFP+IDMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVDP+ S
Sbjct: 121  KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180

Query: 181  NGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREV 240
            NGRIKQLRS         GALQIESSEE+DQGKYECVATNSAG RYS+PANLYVR    V
Sbjct: 181  NGRIKQLRS---------GALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----V 227

Query: 241  RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL 300
            RRVAPRFSI P S E+MPGG+VN+TCVAVG+PMPYVKWM GAE+LT ED+MPVGRNVLEL
Sbjct: 228  RRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLEL 287

Query: 301  TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV 360
            ++V  SANYTCVA+SSLG+IEA AQ+TVK+LPK P   +VTE TATS+T+TWDSGN +PV
Sbjct: 288  SNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPV 347

Query: 361  SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR 420
            +YY I+Y++   +GP+Q  + + TTRYSIGGLSP SEY   V AVNSIG+GPPSE+V  R
Sbjct: 348  TYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRAR 407

Query: 421  TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 480
            TGEQAP+S PR VQARMLSA+TM+VQWE P EPNGL+RGYRVYYT +   P   W KHN 
Sbjct: 408  TGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNT 467

Query: 481  DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 540
            D  LLTTVGSLL   TY++RVLAFT+VGDGP S  IQVKTQQGVP QP + +AE  S+T 
Sbjct: 468  DAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTR 527

Query: 541  ITLSWSPPRQESIIKYELLFREG-DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSP 599
            I LSW  P QE II YEL++    D  ++   TFDPT+SY +EDLKP+T Y F+LAARS 
Sbjct: 528  IQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSD 587

Query: 600  QGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYR 659
             G+G FTP +  RT QS PSAPPQ V CVS+ ST + VSW PPP ++ NG +  YSV Y 
Sbjct: 588  MGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYE 647

Query: 660  PLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDV 719
             +  ED     V+GI    +   L  LEKWT+YR+   AHT+VGPGPESSPV+VRTDEDV
Sbjct: 648  AVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDV 707

Query: 720  PSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVML 779
            PS PPRKVE E LN+TA+ V W+ P P +QHGQIRGYQV YVR+E  E RG P I+DVML
Sbjct: 708  PSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVML 767

Query: 780  ADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLS 839
            A+AQW  +++ +YE  I+ L PET YS+TVAAYT KGDGARSKPK+V T GAV GRPT+ 
Sbjct: 768  AEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMM 827

Query: 840  VQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGA 899
            +  T   + L +W PP      ++LGYRLQ+ R D     T++F   +  +T +G+HKG 
Sbjct: 828  ISTTAMNTALLQWHPPK-ELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGT 886

Query: 900  TYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERN 959
            TY+FRLAA++R GLGEE  + +  PED P G PQ L   G  +  T  L W PPV AERN
Sbjct: 887  TYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTG-LTTSTTELAWDPPVLAERN 945

Query: 960  GAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPG 1019
            G I+ YTV  R+  +     + EL        +   TL GLKPDT YD++VRA T +G G
Sbjct: 946  GRIISYTVVFRDINS-----QQELQNIT---TDTRFTLTGLKPDTTYDIKVRAWTSKGSG 997

Query: 1020 PFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDG 1079
            P SP ++ RT   +QV  KNF+V   MKTSVLLSWE PD+Y S  P+KI YNG +++VDG
Sbjct: 998  PLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDG 1057

Query: 1080 RTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIM 1139
             + +KLI  L+P+T Y+FVL NRGSS GGLQ  V+  TA +LL  KP  A     DG   
Sbjct: 1058 HSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFD 1117

Query: 1140 VYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGS-PEDMDLEELIQDISRLQRRSLRH 1198
            + +P  Q P  V+ ++IV+VP+ +  GG  LTP  S PE+++L+EL++ I +      R 
Sbjct: 1118 LSMPHVQDPSLVRWFYIVVVPIDRV-GGSMLTPRWSTPEELELDELLEAIEQGGEEQRRR 1176

Query: 1199 SRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQK--SEPT 1256
             RQ E  +PY+AA+  VLP TF  GD+K Y GF NR L P   Y  FVLA L++   +  
Sbjct: 1177 RRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKR 1236

Query: 1257 FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK----PDS 1312
            +A+SP+SD   +     Q   + E  ++WV GPVLAV+ II IVIAILL+K K    P S
Sbjct: 1237 YASSPYSDEIVVQVTPAQQQEEPE--MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSS 1294

Query: 1313 KRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPP 1372
            K + S      LL        H  DPVEMRR+N+QTP                 M  HPP
Sbjct: 1295 KDEQSIGLKDSLLA-------HSSDPVEMRRLNYQTP----------------GMRDHPP 1331

Query: 1373 IPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSR 1432
            IPI D+A++ ERLKAND LK SQEYESIDPGQQFTWE+SNLEVNKPKNRYANVIAYDHSR
Sbjct: 1332 IPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSR 1391

Query: 1433 VILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1492
            VIL  I+G+ GSDYINANY+DGYR QNAYIATQGPLPET GDFWRMVWEQR+AT+VMMTR
Sbjct: 1392 VILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTR 1451

Query: 1493 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1552
            LEEKSR+KCDQYWP RGTET G IQVTLLDT+ELAT+ VRTF+LHK+GSSEKRE+RQFQF
Sbjct: 1452 LEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQF 1511

Query: 1553 TAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPE 1612
             AWPDHGVPEYPTP LAFLRRVK CNP DAGP+VVHCSAGVGRTGCFIVIDAMLER+K E
Sbjct: 1512 MAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHE 1571

Query: 1613 KTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVE 1672
            KTVD+YGHVT MRSQRNYMVQTEDQY FIHEALLEA  CG+TEVPAR+LYA+IQKL QV 
Sbjct: 1572 KTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVP 1631

Query: 1673 PGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG 1732
            PGE VT MELEFK LA+SKAHTSRFISANLPCNKFKNRLVNIMPYE TRVCLQPIRGVEG
Sbjct: 1632 PGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEG 1691

Query: 1733 SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQ 1792
            SDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWE+NSTI+VMLTKLREMGREKCHQ
Sbjct: 1692 SDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQ 1751

Query: 1793 YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKS 1852
            YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT+RQFQFTDWPEQGVPK+
Sbjct: 1752 YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKT 1811

Query: 1853 GEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTV 1912
            GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVFITLSIVLERMRYEGVVD+FQTV
Sbjct: 1812 GEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTV 1871

Query: 1913 KMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1948
            K LRTQRPAMVQTED+YQ CY+AALEYLGSFDHYAT
Sbjct: 1872 KTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1907


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score = 2538 bits (6578), Expect = 0.0
 Identities = 1300/1956 (66%), Positives = 1499/1956 (76%), Gaps = 66/1956 (3%)

Query: 1    MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
            MAP   PG   V     L+++ LV G   +  P FIK P+DQ G+SGGVASFVCQATG+P
Sbjct: 1    MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60

Query: 61   KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
            KPR+TW KKGKKV+SQRFE IEFD+ AG+VLRIQPLR  RDE +YEC A NS+GEI   A
Sbjct: 61   KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120

Query: 121  KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
            KL+VL E+QLP GFP+IDMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVDP+ S
Sbjct: 121  KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180

Query: 181  NGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREV 240
            NGRIKQLRS         GALQIESSEE+DQGKYECVATNSAG RYS+PANLYVR    V
Sbjct: 181  NGRIKQLRS---------GALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----V 227

Query: 241  RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL 300
            RRVAPRFSI P S E+MPGG+VN+TCVAVG+PMPYVKWM GAE+LT ED+MPVGRNVLEL
Sbjct: 228  RRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLEL 287

Query: 301  TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV 360
            ++V  SANYTCVA+SSLG+IEA AQ+TVK+LPK P   +VTE TATS+T+TWDSGN +PV
Sbjct: 288  SNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPV 347

Query: 361  SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR 420
            +YY I+Y++   +GP+Q  + + TTRYSIGGLSP SEY   V AVNSIG+GPPSE+V  R
Sbjct: 348  TYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRAR 407

Query: 421  TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 480
            TGEQAP+S PR VQARMLSA+TM+VQWE P EPNGL+RGYRVYYT +   P   W KHN 
Sbjct: 408  TGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNT 467

Query: 481  DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 540
            D  LLTTVGSLL   TY++RVLAFT+VGDGP S  IQVKTQQGVP QP + +AE  S+T 
Sbjct: 468  DAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTR 527

Query: 541  ITLSWSPPRQESIIKYELLFREG-DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSP 599
            I LSW  P QE II YEL++    D  ++   TFDPT+SY +EDLKP+T Y F+LAARS 
Sbjct: 528  IQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSD 587

Query: 600  QGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYR 659
             G+G FTP +  RT QS PSAPPQ V CVS+ ST + VSW PPP ++ NG +  YSV Y 
Sbjct: 588  MGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYE 647

Query: 660  PLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDV 719
             +  ED     V+GI    +   L  LEKWT+YR+   AHT+VGPGPESSPV+VRTDEDV
Sbjct: 648  AVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDV 707

Query: 720  PSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVML 779
            PS PPRKVE E LN+TA+ V W+ P P +QHGQIRGYQV YVR+E  E RG P I+DVML
Sbjct: 708  PSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVML 767

Query: 780  ADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLS 839
            A+AQ         E  I+ L PET YS+TVAAYT KGDGARSKPK+V T GAV GRPT+ 
Sbjct: 768  AEAQ---------ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMM 818

Query: 840  VQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGA 899
            +  T   + L +W PP      ++LGYRLQ+ R D     T++F   +  +T +G+HKG 
Sbjct: 819  ISTTAMNTALLQWHPPK-ELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGT 877

Query: 900  TYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERN 959
            TY+FRLAA++R GLGEE  + +  PED P G PQ L   G  +  T  L W PPV AERN
Sbjct: 878  TYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTG-LTTSTTELAWDPPVLAERN 936

Query: 960  GAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPG 1019
            G I+ YTV  R+  +     + EL        +   TL GLKPDT YD++VRA T +G G
Sbjct: 937  GRIISYTVVFRDINS-----QQELQNIT---TDTRFTLTGLKPDTTYDIKVRAWTSKGSG 988

Query: 1020 PFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDG 1079
            P SP ++ RT   +QV  KNF+V   MKTSVLLSWE PD+Y S  P+KI YNG +++VDG
Sbjct: 989  PLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDG 1048

Query: 1080 RTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIM 1139
             + +KLI  L+P+T Y+FVL NRGSS GGLQ  V+  TA +LL  KP  A     DG   
Sbjct: 1049 HSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFD 1108

Query: 1140 VYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGS-PEDMDLEELIQDISRLQRRSLRH 1198
            + +P  Q P  V+ ++IV+VP+ +  GG  LTP  S PE+++L+EL++ I +      R 
Sbjct: 1109 LSMPHVQDPSLVRWFYIVVVPIDRV-GGSMLTPRWSTPEELELDELLEAIEQGGEEQRRR 1167

Query: 1199 SRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQK--SEPT 1256
             RQ E  +PY+AA+  VLP TF  GD+K Y GF NR L P   Y  FVLA L++   +  
Sbjct: 1168 RRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKR 1227

Query: 1257 FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK----PDS 1312
            +A+SP+SD   +     Q   + E  ++WV GPVLAV+ II IVIAILL+K K    P S
Sbjct: 1228 YASSPYSDEIVVQVTPAQQQEEPE--MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSS 1285

Query: 1313 KRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPP 1372
            K + S      LL        H  DPVEMRR+N+QTP                 M  HPP
Sbjct: 1286 KDEQSIGLKDSLLA-------HSSDPVEMRRLNYQTP----------------GMRDHPP 1322

Query: 1373 IPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSR 1432
            IPI D+A++ ERLKAND LK SQEYESIDPGQQFTWE+SNLEVNKPKNRYANVIAYDHSR
Sbjct: 1323 IPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSR 1382

Query: 1433 VILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1492
            VIL  I+G+ GSDYINANY+DGYR QNAYIATQGPLPET GDFWRMVWEQR+AT+VMMTR
Sbjct: 1383 VILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTR 1442

Query: 1493 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1552
            LEEKSR+KCDQYWP RGTET G IQVTLLDT+ELAT+ VRTF+LHK+GSSEKRE+RQFQF
Sbjct: 1443 LEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQF 1502

Query: 1553 TAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPE 1612
             AWPDHGVPEYPTP LAFLRRVK CNP DAGP+VVHCSAGVGRTGCFIVIDAMLER+K E
Sbjct: 1503 MAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHE 1562

Query: 1613 KTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVE 1672
            KTVD+YGHVT MRSQRNYMVQTEDQY FIHEALLEA  CG+TEVPAR+LYA+IQKL QV 
Sbjct: 1563 KTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVP 1622

Query: 1673 PGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG 1732
            PGE VT MELEFK LA+SKAHTSRFISANLPCNKFKNRLVNIMPYE TRVCLQPIRGVEG
Sbjct: 1623 PGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEG 1682

Query: 1733 SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQ 1792
            SDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWE+NSTI+VMLTKLREMGREKCHQ
Sbjct: 1683 SDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQ 1742

Query: 1793 YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKS 1852
            YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT+RQFQFTDWPEQGVPK+
Sbjct: 1743 YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKT 1802

Query: 1853 GEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTV 1912
            GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVFITLSIVLERMRYEGVVD+FQTV
Sbjct: 1803 GEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTV 1862

Query: 1913 KMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1948
            K LRTQRPAMVQTED+YQ CY+AALEYLGSFDHYAT
Sbjct: 1863 KTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1898


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
            isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score = 1897 bits (4915), Expect = 0.0
 Identities = 985/1291 (76%), Positives = 1046/1291 (81%), Gaps = 61/1291 (4%)

Query: 662  GSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPS 721
            G+ED  P++   +P     + L  ++    Y  T VA + +G     + + V++   +P 
Sbjct: 272  GAEDLTPED--DMPVGRNVLELTDVKDSANY--TCVAMSSLGVIEAVAQITVKS---LPK 324

Query: 722  APPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLAD 781
            AP   +  E   AT+I + W S  P      +  Y + Y   +     GP +IK+     
Sbjct: 325  APGTPMVTEN-TATSITITWDSGNPD----PVSYYVIEY---KSKSQDGPYQIKE----- 371

Query: 782  AQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQ 841
                  D       I  L P + Y I V+A    G G  S+  V  T          +VQ
Sbjct: 372  ------DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQ 425

Query: 842  --QTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRY--TASGVHK 897
                   +++ +WE P       + GYR+ +  E   P+   +    +D    T   + +
Sbjct: 426  ARMLSATTMIVQWEEPV-EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 484

Query: 898  GATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAE 957
              TY  R+ A +  G G  +  +    +    G P  L A   +   ++ L W PP    
Sbjct: 485  DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET-SITLSWSPP---- 539

Query: 958  RNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRG 1017
            R  +I+KY +  RE          E+    +P    +  ++ LKP+T Y  ++ A + +G
Sbjct: 540  RQESIIKYELLFREGD-----HGREVGRTFDP--TTSYVVEDLKPNTEYAFRLAARSPQG 592

Query: 1018 PGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDV 1077
             G F+P VR RT     +SPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDV
Sbjct: 593  LGAFTPVVRQRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDV 650

Query: 1078 DGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF 1137
            DGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF
Sbjct: 651  DGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF 710

Query: 1138 IMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLR 1197
            IMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLR
Sbjct: 711  IMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLR 770

Query: 1198 HSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTF 1257
            HSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTF
Sbjct: 771  HSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTF 830

Query: 1258 AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS 1317
            AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS
Sbjct: 831  AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS 890

Query: 1318 EPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPIPIAD 1377
            EPRTKCLLNNADLAPHHPKDPVEMRRINFQTP                 MLSHPPIPIAD
Sbjct: 891  EPRTKCLLNNADLAPHHPKDPVEMRRINFQTP----------------GMLSHPPIPIAD 934

Query: 1378 MAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQP 1437
            MAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQP
Sbjct: 935  MAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQP 994

Query: 1438 IEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKS 1497
            IEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKS
Sbjct: 995  IEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKS 1054

Query: 1498 RIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPD 1557
            RIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPD
Sbjct: 1055 RIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPD 1114

Query: 1558 HGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDV 1617
            HGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDV
Sbjct: 1115 HGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDV 1174

Query: 1618 YGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHV 1677
            YGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHV
Sbjct: 1175 YGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHV 1234

Query: 1678 TGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYIN 1737
            TGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYIN
Sbjct: 1235 TGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYIN 1294

Query: 1738 ASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE 1797
            ASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE
Sbjct: 1295 ASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE 1354

Query: 1798 RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFI 1857
            RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFI
Sbjct: 1355 RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFI 1414

Query: 1858 DFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRT 1917
            DFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRT
Sbjct: 1415 DFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRT 1474

Query: 1918 QRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1948
            QRPAMVQTEDEYQFCYQAALEYLGSFDHYAT
Sbjct: 1475 QRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1505



 Score = 1227 bits (3174), Expect = 0.0
 Identities = 618/661 (93%), Positives = 628/661 (95%), Gaps = 15/661 (2%)

Query: 1   MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
           MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP
Sbjct: 1   MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60

Query: 61  KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
           KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA
Sbjct: 61  KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120

Query: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
           KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS
Sbjct: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180

Query: 181 NGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREV 240
           NGRIKQLRS         GALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREV
Sbjct: 181 NGRIKQLRS---------GALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREV 231

Query: 241 RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL 300
           RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL
Sbjct: 232 RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL 291

Query: 301 TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV 360
           TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV
Sbjct: 292 TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV 351

Query: 361 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR 420
           SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR
Sbjct: 352 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR 411

Query: 421 TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 480
           TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV
Sbjct: 412 TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 471

Query: 481 DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 540
           DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS
Sbjct: 472 DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 531

Query: 541 ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 600
           ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ
Sbjct: 532 ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 591

Query: 601 GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRP 660
           GLGAFTPVVRQRTLQ   S  P++ K   +  T++L+SW    P+ +N     Y ++Y  
Sbjct: 592 GLGAFTPVVRQRTLQ---SISPKNFKVKMIMKTSVLLSWE--FPDNYNSP-TPYKIQYNG 645

Query: 661 L 661
           L
Sbjct: 646 L 646



 Score =  123 bits (309), Expect = 2e-27
 Identities = 161/729 (22%), Positives = 292/729 (40%), Gaps = 97/729 (13%)

Query: 152 ATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGA-LQIESSEET- 209
           A+ +C A+G+P P +TW K            ++   R ET E     GA L+I+      
Sbjct: 50  ASFVCQATGDPKPRVTWNK---------KGKKVNSQRFETIEFDESAGAVLRIQPLRTPR 100

Query: 210 DQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAV 269
           D+  YECVA NS G   +  A L V    ++    P   + P    +       + C A 
Sbjct: 101 DENVYECVAQNSVG-EITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAAS 159

Query: 270 GSPMPYVKWMQGAEDLTPE------DDMPVGRNVLELTDVKDSANYTCVAMSSLGV-IEA 322
           G+P P + W +    + P         +  G   +E ++  D   Y CVA +S GV   +
Sbjct: 160 GNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSS 219

Query: 323 VAQITVKSL-------PKAPGTPMVTE-NTATSITITWDS-GNPDPVSYYVIEYKSKSQD 373
            A + V+ L       P+    PM  E     ++ IT  + G+P P     +++   ++D
Sbjct: 220 PANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPY----VKWMQGAED 275

Query: 374 GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 433
                ++D+   R  +              A++S+G     E+V   T +  P  AP   
Sbjct: 276 --LTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGV---IEAVAQITVKSLP-KAPGTP 329

Query: 434 QARMLSATTMIVQWE----EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT-- 487
                +AT++ + W+    +PV           YY +E +    +   + + + + TT  
Sbjct: 330 MVTENTATSITITWDSGNPDPVS----------YYVIEYKSKSQDGP-YQIKEDITTTRY 378

Query: 488 -VGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSW 545
            +G L  +  Y + V A  S+G GP S+ +  +T +  P   P N++A   S T++ + W
Sbjct: 379 SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQW 438

Query: 546 SPPRQES--IIKYELLFR-EGDH--GREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 600
             P + +  I  Y + +  E +H  G       D +    V  L  +  Y  R+ A +  
Sbjct: 439 EEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSV 498

Query: 601 GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRP 660
           G G  +  ++ +T Q  P  P  +++  +   T+I +SW PP  E+         ++Y  
Sbjct: 499 GDGPLSDPIQVKTQQGVPGQP-MNLRAEARSETSITLSWSPPRQES--------IIKYEL 549

Query: 661 LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 720
           L  E    +EV      TT  ++E L+  T+Y     A +  G G  +  V  RT   + 
Sbjct: 550 LFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT---LQ 606

Query: 721 SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 780
           S  P+  + + +  T++ + W  P     +     Y++ Y               + +  
Sbjct: 607 SISPKNFKVKMIMKTSVLLSWEFP---DNYNSPTPYKIQY---------------NGLTL 648

Query: 781 DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 840
           D    T      + +IT+L+P T Y+  +        G +           + G+P+++ 
Sbjct: 649 DVDGRTT-----KKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP 703

Query: 841 QQTPEGSLL 849
           +   +G ++
Sbjct: 704 KPDADGFIM 712


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
            isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score = 1897 bits (4915), Expect = 0.0
 Identities = 985/1291 (76%), Positives = 1046/1291 (81%), Gaps = 61/1291 (4%)

Query: 662  GSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPS 721
            G+ED  P++   +P     + L  ++    Y  T VA + +G     + + V++   +P 
Sbjct: 268  GAEDLTPED--DMPVGRNVLELTDVKDSANY--TCVAMSSLGVIEAVAQITVKS---LPK 320

Query: 722  APPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLAD 781
            AP   +  E   AT+I + W S  P      +  Y + Y   +     GP +IK+     
Sbjct: 321  APGTPMVTEN-TATSITITWDSGNPD----PVSYYVIEY---KSKSQDGPYQIKE----- 367

Query: 782  AQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQ 841
                  D       I  L P + Y I V+A    G G  S+  V  T          +VQ
Sbjct: 368  ------DITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQ 421

Query: 842  --QTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRY--TASGVHK 897
                   +++ +WE P       + GYR+ +  E   P+   +    +D    T   + +
Sbjct: 422  ARMLSATTMIVQWEEPV-EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480

Query: 898  GATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAE 957
              TY  R+ A +  G G  +  +    +    G P  L A   +   ++ L W PP    
Sbjct: 481  DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET-SITLSWSPP---- 535

Query: 958  RNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRG 1017
            R  +I+KY +  RE          E+    +P    +  ++ LKP+T Y  ++ A + +G
Sbjct: 536  RQESIIKYELLFREGD-----HGREVGRTFDP--TTSYVVEDLKPNTEYAFRLAARSPQG 588

Query: 1018 PGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDV 1077
             G F+P VR RT     +SPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDV
Sbjct: 589  LGAFTPVVRQRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDV 646

Query: 1078 DGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF 1137
            DGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF
Sbjct: 647  DGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGF 706

Query: 1138 IMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLR 1197
            IMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLR
Sbjct: 707  IMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLR 766

Query: 1198 HSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTF 1257
            HSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTF
Sbjct: 767  HSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTF 826

Query: 1258 AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS 1317
            AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS
Sbjct: 827  AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS 886

Query: 1318 EPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPIPIAD 1377
            EPRTKCLLNNADLAPHHPKDPVEMRRINFQTP                 MLSHPPIPIAD
Sbjct: 887  EPRTKCLLNNADLAPHHPKDPVEMRRINFQTP----------------GMLSHPPIPIAD 930

Query: 1378 MAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQP 1437
            MAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQP
Sbjct: 931  MAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQP 990

Query: 1438 IEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKS 1497
            IEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKS
Sbjct: 991  IEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKS 1050

Query: 1498 RIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPD 1557
            RIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPD
Sbjct: 1051 RIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPD 1110

Query: 1558 HGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDV 1617
            HGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDV
Sbjct: 1111 HGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDV 1170

Query: 1618 YGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHV 1677
            YGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHV
Sbjct: 1171 YGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHV 1230

Query: 1678 TGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYIN 1737
            TGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYIN
Sbjct: 1231 TGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYIN 1290

Query: 1738 ASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE 1797
            ASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE
Sbjct: 1291 ASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE 1350

Query: 1798 RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFI 1857
            RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFI
Sbjct: 1351 RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFI 1410

Query: 1858 DFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRT 1917
            DFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRT
Sbjct: 1411 DFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRT 1470

Query: 1918 QRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1948
            QRPAMVQTEDEYQFCYQAALEYLGSFDHYAT
Sbjct: 1471 QRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1501



 Score = 1214 bits (3140), Expect = 0.0
 Identities = 614/661 (92%), Positives = 624/661 (94%), Gaps = 19/661 (2%)

Query: 1   MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
           MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP
Sbjct: 1   MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60

Query: 61  KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
           KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA
Sbjct: 61  KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120

Query: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
           KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS
Sbjct: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180

Query: 181 NGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREV 240
           NGRIKQLRS         GALQIESSEETDQGKYECVATNSAGVRYSSPANLYVR    V
Sbjct: 181 NGRIKQLRS---------GALQIESSEETDQGKYECVATNSAGVRYSSPANLYVR----V 227

Query: 241 RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL 300
           RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL
Sbjct: 228 RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL 287

Query: 301 TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV 360
           TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV
Sbjct: 288 TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV 347

Query: 361 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR 420
           SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR
Sbjct: 348 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR 407

Query: 421 TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 480
           TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV
Sbjct: 408 TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 467

Query: 481 DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 540
           DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS
Sbjct: 468 DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 527

Query: 541 ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 600
           ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ
Sbjct: 528 ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 587

Query: 601 GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRP 660
           GLGAFTPVVRQRTLQ   S  P++ K   +  T++L+SW    P+ +N     Y ++Y  
Sbjct: 588 GLGAFTPVVRQRTLQ---SISPKNFKVKMIMKTSVLLSWE--FPDNYNSP-TPYKIQYNG 641

Query: 661 L 661
           L
Sbjct: 642 L 642



 Score =  123 bits (308), Expect = 2e-27
 Identities = 161/725 (22%), Positives = 291/725 (40%), Gaps = 93/725 (12%)

Query: 152 ATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGA-LQIESSEET- 209
           A+ +C A+G+P P +TW K            ++   R ET E     GA L+I+      
Sbjct: 50  ASFVCQATGDPKPRVTWNK---------KGKKVNSQRFETIEFDESAGAVLRIQPLRTPR 100

Query: 210 DQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAV 269
           D+  YECVA NS G   +  A L V    ++    P   + P    +       + C A 
Sbjct: 101 DENVYECVAQNSVG-EITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAAS 159

Query: 270 GSPMPYVKWMQGAEDLTPE------DDMPVGRNVLELTDVKDSANYTCVAMSSLGV-IEA 322
           G+P P + W +    + P         +  G   +E ++  D   Y CVA +S GV   +
Sbjct: 160 GNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSS 219

Query: 323 VAQITVKSLPKAPG---TPMVTE-NTATSITITWDS-GNPDPVSYYVIEYKSKSQDGPYQ 377
            A + V+    AP     PM  E     ++ IT  + G+P P     +++   ++D    
Sbjct: 220 PANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPY----VKWMQGAED--LT 273

Query: 378 IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARM 437
            ++D+   R  +              A++S+G     E+V   T +  P  AP       
Sbjct: 274 PEDDMPVGRNVLELTDVKDSANYTCVAMSSLGV---IEAVAQITVKSLP-KAPGTPMVTE 329

Query: 438 LSATTMIVQWE----EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT---VGS 490
            +AT++ + W+    +PV           YY +E +    +   + + + + TT   +G 
Sbjct: 330 NTATSITITWDSGNPDPVS----------YYVIEYKSKSQDGP-YQIKEDITTTRYSIGG 378

Query: 491 LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPR 549
           L  +  Y + V A  S+G GP S+ +  +T +  P   P N++A   S T++ + W  P 
Sbjct: 379 LSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV 438

Query: 550 QES--IIKYELLFR-EGDH--GREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGA 604
           + +  I  Y + +  E +H  G       D +    V  L  +  Y  R+ A +  G G 
Sbjct: 439 EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 498

Query: 605 FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSE 664
            +  ++ +T Q  P  P  +++  +   T+I +SW PP  E+         ++Y  L  E
Sbjct: 499 LSDPIQVKTQQGVPGQP-MNLRAEARSETSITLSWSPPRQES--------IIKYELLFRE 549

Query: 665 DPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPP 724
               +EV      TT  ++E L+  T+Y     A +  G G  +  V  RT   + S  P
Sbjct: 550 GDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT---LQSISP 606

Query: 725 RKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQW 784
           +  + + +  T++ + W  P     +     Y++ Y               + +  D   
Sbjct: 607 KNFKVKMIMKTSVLLSWEFP---DNYNSPTPYKIQY---------------NGLTLDVDG 648

Query: 785 ETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTP 844
            T      + +IT+L+P T Y+  +        G +           + G+P+++ +   
Sbjct: 649 RTT-----KKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDA 703

Query: 845 EGSLL 849
           +G ++
Sbjct: 704 DGFIM 708


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
            precursor [Homo sapiens]
          Length = 1502

 Score = 1504 bits (3895), Expect = 0.0
 Identities = 798/1295 (61%), Positives = 951/1295 (73%), Gaps = 67/1295 (5%)

Query: 661  LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 720
            LG+ED  P++   +P     + L  + +   Y  T VA + +G     + + V+    +P
Sbjct: 268  LGAEDLTPED--DMPIGRNVLELNDVRQSANY--TCVAMSTLGVIEAIAQITVKA---LP 320

Query: 721  SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 780
              P   V  E+  AT+I + W S  P           V Y  ++          K++   
Sbjct: 321  KPPGTPVVTES-TATSITLTWDSGNPE---------PVSYYIIQHKPKNSEELYKEI--- 367

Query: 781  DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 840
                  D  A     +  L P + Y   V A    G G  S+P +  T           V
Sbjct: 368  ------DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 421

Query: 841  QQTPEGS--LLARWEPPAGTAEDQVLGYRLQFGREDSTPLAT-LEFPPSEDRYTASG-VH 896
            Q     S  +L +W+ P      Q+ GYR+ +  + +  +   ++   ++ + T  G + 
Sbjct: 422  QARMLSSTTILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 480

Query: 897  KGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPA 956
               TY  ++ A +  G G  ++++  I +    G P   +A   +   ++LL W PP   
Sbjct: 481  PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESET-SILLSWTPP--- 536

Query: 957  ERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRR 1016
             R+  I  Y +  ++ G  G  +   +    EPG   +  LQGLKP++ Y  ++ A + +
Sbjct: 537  -RSDTIANYELVYKD-GEHGEEQRITI----EPGT--SYRLQGLKPNSLYYFRLAARSPQ 588

Query: 1017 GPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG--LT 1074
            G G  +  +  RT     +  KNF VK +MKTSVLLSWE P+NYNS  P+KI Y+   + 
Sbjct: 589  GLGASTAEISARTM--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMV 646

Query: 1075 LDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDA 1134
             +VDGR T+KLI +LKP   Y+FVLTNRG+S GGLQ  VTA TA ++L  KP+   K + 
Sbjct: 647  EEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL 706

Query: 1135 DGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRR 1194
            DG I V LP+  +   ++ Y+I++VPL+KSRG +F+ P  SP++M+L+EL+++ISR +RR
Sbjct: 707  DGMITVQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR-KRR 764

Query: 1195 SLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSE 1254
            S+R+ R++E+ +PYIAA F VLP  F  GD K YGGF N+ L+ G  YV FVLAV++ +E
Sbjct: 765  SIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAE 823

Query: 1255 PT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSK 1313
               +A SP+SDP    + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK+KPD K
Sbjct: 824  SKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRK 883

Query: 1314 RKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPI 1373
            R +S+ R   + NN ++  HHP DPVE+RR+NFQTP                 M SHPPI
Sbjct: 884  RAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTP----------------GMASHPPI 927

Query: 1374 PIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV 1433
            PI ++A+H ERLKAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV
Sbjct: 928  PILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV 987

Query: 1434 ILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRL 1493
            +L  IEGI GSDY+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+L
Sbjct: 988  LLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKL 1047

Query: 1494 EEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFT 1553
            EE+SR+KCDQYWP+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFT
Sbjct: 1048 EERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFT 1107

Query: 1554 AWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEK 1613
            AWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EK
Sbjct: 1108 AWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEK 1167

Query: 1614 TVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEP 1673
            TVD+YGHVTLMR+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E 
Sbjct: 1168 TVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIET 1227

Query: 1674 GEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS 1733
            GE+VTGMELEFKRLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS
Sbjct: 1228 GENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS 1287

Query: 1734 DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQY 1793
            DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQY
Sbjct: 1288 DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQY 1347

Query: 1794 WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSG 1853
            WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSG
Sbjct: 1348 WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSG 1407

Query: 1854 EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK 1913
            EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK
Sbjct: 1408 EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK 1467

Query: 1914 MLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1948
            MLRTQRPAMVQTED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1468 MLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1502



 Score =  906 bits (2342), Expect = 0.0
 Identities = 471/771 (61%), Positives = 578/771 (74%), Gaps = 31/771 (4%)

Query: 29  AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
           AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20  AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79

Query: 89  AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
           +VLRIQPLRTPRDE +YECVA N+VGEI+V  +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80  SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139

Query: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEE 208
           TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS     TPIRGALQIE SEE
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSG---GTPIRGALQIEQSEE 196

Query: 209 TDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVA 268
           +DQGKYECVATNSAG RYS+PANLYVRELREVRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 197 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 256

Query: 269 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 328
           VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 257 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 316

Query: 329 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 388
           K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ +  Y+  + + TTRYS
Sbjct: 317 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 376

Query: 389 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 448
           + GLSP S+YE  V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 377 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 436

Query: 449 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 508
           EP EPNG I+GYRVYYTM+P   V NW KHNV DS +TT+G+L+  +TY+V+VLAFTS+G
Sbjct: 437 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 496

Query: 509 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 568
           DGPLS  IQV TQ GVPGQP+N +AE  SETSI LSW+PPR ++I  YEL++++G+HG E
Sbjct: 497 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 556

Query: 569 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 628
              T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T  +  RT+QS  +   ++    
Sbjct: 557 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFA---KNFHVK 613

Query: 629 SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 688
           +V  T++L+SW    PE +N A+      ++ L  +    +EV+G     TQ L+  L+ 
Sbjct: 614 AVMKTSVLLSWE--IPENYNSAM-----PFKILYDDGKMVEEVDG---RATQKLIVNLKP 663

Query: 689 WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 748
              Y            G +   V  +T  DV    P  +    L+      L   PA   
Sbjct: 664 EKSYSFVLTNRGNSAGGLQHR-VTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA--- 719

Query: 749 QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNL 799
            +  I+GY +  V ++  ++RG   IK        WE+ D  E + ++  +
Sbjct: 720 -NENIKGYYIIIVPLK--KSRG-KFIK-------PWESPDEMELDELLKEI 759



 Score =  137 bits (345), Expect = 1e-31
 Identities = 181/776 (23%), Positives = 298/776 (38%), Gaps = 122/776 (15%)

Query: 237 LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 288
           LR      PRF+  P+    + GG  +  C A G P P + W         Q  E +  +
Sbjct: 16  LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75

Query: 289 DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 339
           D       +  L   +D A Y CVA +++G I    ++TV    + P G P         
Sbjct: 76  DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135

Query: 340 VTENTATSITITWDSGNPDP-VSYY-----------------------------VIEYKS 369
           V E T T+  +   SGNPDP ++++                              IE   
Sbjct: 136 VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSE 195

Query: 370 KSQDGPYQ-IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPAS 428
           +S  G Y+ +  +   TRYS       +   ++V  +  + + PP  S+     E  P  
Sbjct: 196 ESDQGKYECVATNSAGTRYS-------APANLYVRELREVRRVPPRFSIPPTNHEIMPGG 248

Query: 429 APRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTV 488
           +  N+    + +    V+W    E            T E + P+G     NV       +
Sbjct: 249 SV-NITCVAVGSPMPYVKWMLGAED----------LTPEDDMPIG----RNV-----LEL 288

Query: 489 GSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPP 548
             + +   YT   +A +++G       I VK     PG P+   + A   TSITL+W   
Sbjct: 289 NDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTWDSG 343

Query: 549 RQESIIKYELLFREGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFT 606
             E  + Y ++  +  +  E+ +  D   TT Y V  L P ++Y FR+ A +  G G  +
Sbjct: 344 NPEP-VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPS 402

Query: 607 PVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDP 666
             V  +T +  PS+ P+DV+   + ST ILV W+   PE  NG + GY V Y    + DP
Sbjct: 403 EPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYY----TMDP 456

Query: 667 EPKEVNGIPPTTTQILLEA---LEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAP 723
                N +        +     L     Y +  +A T +G GP SS + V T   VP   
Sbjct: 457 TQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP-GQ 515

Query: 724 PRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQ 783
           P   +AE  + T+I + W  P    +   I  Y++ Y   E  E             + +
Sbjct: 516 PLNFKAEPESETSILLSWTPP----RSDTIANYELVYKDGEHGE-------------EQR 558

Query: 784 WETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQT 843
              +    Y   +  L+P + Y   +AA + +G GA +      T  ++  +    V+  
Sbjct: 559 ITIEPGTSYR--LQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAK-NFHVKAV 615

Query: 844 PEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVF 903
            + S+L  WE P     +  + +++ +  +D   +  ++   ++         K  ++V 
Sbjct: 616 MKTSVLLSWEIPEN--YNSAMPFKILY--DDGKMVEEVDGRATQKLIVNLKPEKSYSFVL 671

Query: 904 RLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERN 959
                S GGL            D  R  P  +   G  +   ++   LP VPA  N
Sbjct: 672 TNRGNSAGGLQHRV--TAKTAPDVLRTKPAFI---GKTNLDGMITVQLPEVPANEN 722


>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
            precursor [Homo sapiens]
          Length = 1501

 Score = 1492 bits (3862), Expect = 0.0
 Identities = 795/1295 (61%), Positives = 947/1295 (73%), Gaps = 71/1295 (5%)

Query: 661  LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 720
            LG+ED  P++   +P     + L  + +   Y  T VA + +G     + + V+    +P
Sbjct: 271  LGAEDLTPED--DMPIGRNVLELNDVRQSANY--TCVAMSTLGVIEAIAQITVKA---LP 323

Query: 721  SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 780
              P   V  E+  AT+I + W S  P           V Y  ++          K++   
Sbjct: 324  KPPGTPVVTES-TATSITLTWDSGNPE---------PVSYYIIQHKPKNSEELYKEI--- 370

Query: 781  DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 840
                  D  A     +  L P + Y   V A    G G  S+P +  T           V
Sbjct: 371  ------DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 424

Query: 841  QQTPEGS--LLARWEPPAGTAEDQVLGYRLQFGREDSTPLAT-LEFPPSEDRYTASG-VH 896
            Q     S  +L +W+ P      Q+ GYR+ +  + +  +   ++   ++ + T  G + 
Sbjct: 425  QARMLSSTTILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 483

Query: 897  KGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPA 956
               TY  ++ A +  G G  ++++  I +    G P   +A   +   ++LL W PP   
Sbjct: 484  PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESET-SILLSWTPP--- 539

Query: 957  ERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRR 1016
             R+  I  Y +  ++ G  G  +   +    EPG   +  LQGLKP++ Y  ++ A + +
Sbjct: 540  -RSDTIANYELVYKD-GEHGEEQRITI----EPGT--SYRLQGLKPNSLYYFRLAARSPQ 591

Query: 1017 GPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG--LT 1074
            G G  +  +  RT     +  KNF VK +MKTSVLLSWE P+NYNS  P+KI Y+   + 
Sbjct: 592  GLGASTAEISARTM--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMV 649

Query: 1075 LDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDA 1134
             +VDGR T+KLI +LKP   Y+FVLTNRG+S GGLQ  VTA TA ++L  KP+   K + 
Sbjct: 650  EEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL 709

Query: 1135 DGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRR 1194
            DG I V LP+  +   ++ Y+I++VPL+KSRG +F+ P  SP++M+L+EL+++ISR +RR
Sbjct: 710  DGMITVQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR-KRR 767

Query: 1195 SLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSE 1254
            S+R+ R++E+ +PYIAA F VLP  F  GD K YGGF N+ L+ G  YV FVLAV++ +E
Sbjct: 768  SIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAE 826

Query: 1255 PT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSK 1313
               +A SP+SDP    + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK K    
Sbjct: 827  SKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRK---- 882

Query: 1314 RKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPI 1373
            R +S+ R   + NN ++  HHP DPVE+RR+NFQTP                 M SHPPI
Sbjct: 883  RAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTP----------------GMASHPPI 926

Query: 1374 PIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV 1433
            PI ++A+H ERLKAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV
Sbjct: 927  PILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV 986

Query: 1434 ILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRL 1493
            +L  IEGI GSDY+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+L
Sbjct: 987  LLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKL 1046

Query: 1494 EEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFT 1553
            EE+SR+KCDQYWP+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFT
Sbjct: 1047 EERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFT 1106

Query: 1554 AWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEK 1613
            AWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EK
Sbjct: 1107 AWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEK 1166

Query: 1614 TVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEP 1673
            TVD+YGHVTLMR+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E 
Sbjct: 1167 TVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIET 1226

Query: 1674 GEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS 1733
            GE+VTGMELEFKRLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS
Sbjct: 1227 GENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS 1286

Query: 1734 DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQY 1793
            DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQY
Sbjct: 1287 DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQY 1346

Query: 1794 WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSG 1853
            WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSG
Sbjct: 1347 WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSG 1406

Query: 1854 EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK 1913
            EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK
Sbjct: 1407 EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK 1466

Query: 1914 MLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1948
            MLRTQRPAMVQTED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1467 MLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1501



 Score =  914 bits (2362), Expect = 0.0
 Identities = 472/771 (61%), Positives = 580/771 (75%), Gaps = 28/771 (3%)

Query: 29  AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
           AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20  AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79

Query: 89  AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
           +VLRIQPLRTPRDE +YECVA N+VGEI+V  +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80  SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139

Query: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEE 208
           TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRSE+   TPIRGALQIE SEE
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199

Query: 209 TDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVA 268
           +DQGKYECVATNSAG RYS+PANLYVRELREVRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259

Query: 269 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 328
           VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319

Query: 329 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 388
           K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ +  Y+  + + TTRYS
Sbjct: 320 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379

Query: 389 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 448
           + GLSP S+YE  V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 380 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439

Query: 449 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 508
           EP EPNG I+GYRVYYTM+P   V NW KHNV DS +TT+G+L+  +TY+V+VLAFTS+G
Sbjct: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499

Query: 509 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 568
           DGPLS  IQV TQ GVPGQP+N +AE  SETSI LSW+PPR ++I  YEL++++G+HG E
Sbjct: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559

Query: 569 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 628
              T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T  +  RT+QS  +   ++    
Sbjct: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFA---KNFHVK 616

Query: 629 SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 688
           +V  T++L+SW    PE +N A+      ++ L  +    +EV+G     TQ L+  L+ 
Sbjct: 617 AVMKTSVLLSWE--IPENYNSAM-----PFKILYDDGKMVEEVDG---RATQKLIVNLKP 666

Query: 689 WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 748
              Y            G +   V  +T  DV    P  +    L+      L   PA   
Sbjct: 667 EKSYSFVLTNRGNSAGGLQHR-VTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA--- 722

Query: 749 QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNL 799
            +  I+GY +  V ++  ++RG   IK        WE+ D  E + ++  +
Sbjct: 723 -NENIKGYYIIIVPLK--KSRG-KFIK-------PWESPDEMELDELLKEI 762



 Score =  136 bits (342), Expect = 2e-31
 Identities = 181/779 (23%), Positives = 298/779 (38%), Gaps = 125/779 (16%)

Query: 237 LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 288
           LR      PRF+  P+    + GG  +  C A G P P + W         Q  E +  +
Sbjct: 16  LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75

Query: 289 DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 339
           D       +  L   +D A Y CVA +++G I    ++TV    + P G P         
Sbjct: 76  DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135

Query: 340 VTENTATSITITWDSGNPDP-VSYY--------------------------------VIE 366
           V E T T+  +   SGNPDP ++++                                 IE
Sbjct: 136 VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIE 195

Query: 367 YKSKSQDGPYQ-IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQA 425
              +S  G Y+ +  +   TRYS       +   ++V  +  + + PP  S+     E  
Sbjct: 196 QSEESDQGKYECVATNSAGTRYS-------APANLYVRELREVRRVPPRFSIPPTNHEIM 248

Query: 426 PASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLL 485
           P  +  N+    + +    V+W    E            T E + P+G     NV     
Sbjct: 249 PGGSV-NITCVAVGSPMPYVKWMLGAED----------LTPEDDMPIG----RNV----- 288

Query: 486 TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSW 545
             +  + +   YT   +A +++G       I VK     PG P+   + A   TSITL+W
Sbjct: 289 LELNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTW 343

Query: 546 SPPRQESIIKYELLFREGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLG 603
                E  + Y ++  +  +  E+ +  D   TT Y V  L P ++Y FR+ A +  G G
Sbjct: 344 DSGNPEP-VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRG 402

Query: 604 AFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGS 663
             +  V  +T +  PS+ P+DV+   + ST ILV W+   PE  NG + GY V Y    +
Sbjct: 403 PPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYY----T 456

Query: 664 EDPEPKEVNGIPPTTTQILLEA---LEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 720
            DP     N +        +     L     Y +  +A T +G GP SS + V T   VP
Sbjct: 457 MDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP 516

Query: 721 SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 780
              P   +AE  + T+I + W  P    +   I  Y++ Y   E  E             
Sbjct: 517 -GQPLNFKAEPESETSILLSWTPP----RSDTIANYELVYKDGEHGE------------- 558

Query: 781 DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 840
           + +   +    Y   +  L+P + Y   +AA + +G GA +      T  ++  +    V
Sbjct: 559 EQRITIEPGTSYR--LQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAK-NFHV 615

Query: 841 QQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGAT 900
           +   + S+L  WE P     +  + +++ +  +D   +  ++   ++         K  +
Sbjct: 616 KAVMKTSVLLSWEIPEN--YNSAMPFKILY--DDGKMVEEVDGRATQKLIVNLKPEKSYS 671

Query: 901 YVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERN 959
           +V      S GGL            D  R  P  +   G  +   ++   LP VPA  N
Sbjct: 672 FVLTNRGNSAGGLQHRV--TAKTAPDVLRTKPAFI---GKTNLDGMITVQLPEVPANEN 725


>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
            precursor [Homo sapiens]
          Length = 802

 Score =  588 bits (1516), Expect = e-167
 Identities = 316/700 (45%), Positives = 430/700 (61%), Gaps = 42/700 (6%)

Query: 1256 TFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRK 1315
            TF  S  SD    D  D  PI+     ++  +  +L +VFII ++  +   K K      
Sbjct: 134  TFPPSGNSD--SKDRRDETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHS 187

Query: 1316 DSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRS-PL--REPGFHFESMLSHPP 1372
            +S                        R  N +T D   +S PL  R P  + +    +PP
Sbjct: 188  NS-----------------------FRLSNGRTEDVEPQSVPLLARSPSTNRK----YPP 220

Query: 1373 IPIADMAEHTERLKANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHS 1431
            +P+  + E   R  A+D+    +E+ ++     Q T E ++ E NK KNRY N++ YDHS
Sbjct: 221  LPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHS 280

Query: 1432 RVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMT 1491
            RV L P+EG+  SDYINA++++GY+ +N +IA QGP  ET  DFWRM+WEQ +ATIVM+T
Sbjct: 281  RVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVT 340

Query: 1492 RLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKRE----V 1547
             L+E+   KC QYWP++G  TYG I+V++ D   L  + VR F + + G    R+    +
Sbjct: 341  NLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLI 400

Query: 1548 RQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1607
             QF FT+WPD GVP  P   L FL++VK CNP  AG IVVHCSAGVGRTG F+VIDAML+
Sbjct: 401  TQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLD 460

Query: 1608 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQK 1667
             +  E+ VDVYG V+ +R+QR  MVQT+ QY FI++ALLE    G+TE+   SL  ++QK
Sbjct: 461  MMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQK 520

Query: 1668 LAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1727
            +    PG    G+E EFK+L + K    +  + NLP N  KNR++ I+PYE  RV +   
Sbjct: 521  IYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVK 580

Query: 1728 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGR 1787
            RG E +DY+NASFIDGYRQ+ +YIA+QGPL  T EDFWRM+WE  S  +VMLT+L E G+
Sbjct: 581  RGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQ 640

Query: 1788 EKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQ 1847
            EKC QYWP++    Y    V+   E     Y +R+  VT+ R+ +SR +RQF F  WPE 
Sbjct: 641  EKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEV 700

Query: 1848 GVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVD 1907
            G+P  G+G I  I  V K ++Q G + PI+VHCSAG GRTG F  LS VLER++ EG++D
Sbjct: 701  GIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILD 759

Query: 1908 IFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA 1947
            +FQTVK LR QRP MVQT ++Y+FCY+   EY+ +F  YA
Sbjct: 760  VFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYA 799


>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  587 bits (1512), Expect = e-167
 Identities = 290/583 (49%), Positives = 390/583 (66%), Gaps = 6/583 (1%)

Query: 1370 HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAY 1428
            +PP+P+  + E   R  A+D+    +E+ ++     Q T E ++ E NK KNRY N++ Y
Sbjct: 209  YPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPY 268

Query: 1429 DHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIV 1488
            DHSRV L P+EG+  SDYINA++++GY+ +N +IA QGP  ET  DFWRM+WEQ +ATIV
Sbjct: 269  DHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIV 328

Query: 1489 MMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKRE-- 1546
            M+T L+E+   KC QYWP++G  TYG I+V++ D   L  + VR F + + G    R+  
Sbjct: 329  MVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQ 388

Query: 1547 --VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDA 1604
              + QF FT+WPD GVP  P   L FL++VK CNP  AG IVVHCSAGVGRTG F+VIDA
Sbjct: 389  RLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDA 448

Query: 1605 MLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAY 1664
            ML+ +  E+ VDVYG V+ +R+QR  MVQT+ QY FI++ALLE    G+TE+   SL  +
Sbjct: 449  MLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETH 508

Query: 1665 IQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCL 1724
            +QK+    PG    G+E EFK+L + K    +  + NLP N  KNR++ I+PYE  RV +
Sbjct: 509  LQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVII 568

Query: 1725 QPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLRE 1784
               RG E +DY+NASFIDGYRQ+ +YIA+QGPL  T EDFWRM+WE  S  +VMLT+L E
Sbjct: 569  PVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEE 628

Query: 1785 MGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1844
             G+EKC QYWP++    Y    V+   E     Y +R+  VT+ R+ +SR +RQF F  W
Sbjct: 629  RGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGW 688

Query: 1845 PEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEG 1904
            PE G+P  G+G I  I  V K ++Q G + PI+VHCSAG GRTG F  LS VLER++ EG
Sbjct: 689  PEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEG 747

Query: 1905 VVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA 1947
            ++D+FQTVK LR QRP MVQT ++Y+FCY+   EY+ +F  YA
Sbjct: 748  ILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYA 790


>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  587 bits (1512), Expect = e-167
 Identities = 290/583 (49%), Positives = 390/583 (66%), Gaps = 6/583 (1%)

Query: 1370 HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAY 1428
            +PP+P+  + E   R  A+D+    +E+ ++     Q T E ++ E NK KNRY N++ Y
Sbjct: 209  YPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPY 268

Query: 1429 DHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIV 1488
            DHSRV L P+EG+  SDYINA++++GY+ +N +IA QGP  ET  DFWRM+WEQ +ATIV
Sbjct: 269  DHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIV 328

Query: 1489 MMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKRE-- 1546
            M+T L+E+   KC QYWP++G  TYG I+V++ D   L  + VR F + + G    R+  
Sbjct: 329  MVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQ 388

Query: 1547 --VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDA 1604
              + QF FT+WPD GVP  P   L FL++VK CNP  AG IVVHCSAGVGRTG F+VIDA
Sbjct: 389  RLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDA 448

Query: 1605 MLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAY 1664
            ML+ +  E+ VDVYG V+ +R+QR  MVQT+ QY FI++ALLE    G+TE+   SL  +
Sbjct: 449  MLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETH 508

Query: 1665 IQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCL 1724
            +QK+    PG    G+E EFK+L + K    +  + NLP N  KNR++ I+PYE  RV +
Sbjct: 509  LQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVII 568

Query: 1725 QPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLRE 1784
               RG E +DY+NASFIDGYRQ+ +YIA+QGPL  T EDFWRM+WE  S  +VMLT+L E
Sbjct: 569  PVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEE 628

Query: 1785 MGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1844
             G+EKC QYWP++    Y    V+   E     Y +R+  VT+ R+ +SR +RQF F  W
Sbjct: 629  RGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGW 688

Query: 1845 PEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEG 1904
            PE G+P  G+G I  I  V K ++Q G + PI+VHCSAG GRTG F  LS VLER++ EG
Sbjct: 689  PEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEG 747

Query: 1905 VVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA 1947
            ++D+FQTVK LR QRP MVQT ++Y+FCY+   EY+ +F  YA
Sbjct: 748  ILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYA 790


>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
            precursor [Homo sapiens]
          Length = 700

 Score =  549 bits (1415), Expect = e-156
 Identities = 301/689 (43%), Positives = 420/689 (60%), Gaps = 42/689 (6%)

Query: 1271 PDP---QPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN 1327
            PDP   QP+      L W++ P+L ++ ++ +      ++ +  +    S+ +       
Sbjct: 39   PDPGASQPL------LAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKM------ 86

Query: 1328 ADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAEHTERLKA 1387
                P+   +  E +R+   +     RSP   P  +F       PIP+  + E      A
Sbjct: 87   ----PNGILEEQEQQRVMLLS-----RSP-SGPKKYF-------PIPVEHLEEEIRIRSA 129

Query: 1388 NDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDY 1446
            +D  +  +E+ S+  G  Q T+E +N E N+ KNRY N++  DHSRVIL  ++GI  SDY
Sbjct: 130  DDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDY 189

Query: 1447 INANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWP 1506
            INA+Y+DGY+ +N +IA QGP  ET  DFWRMVWEQ+SATIVM+T L+E+   KC QYWP
Sbjct: 190  INASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWP 249

Query: 1507 NRGTETYGFIQVTLLDTIELATFCVRTFSLHK---NGSSEKREVRQFQFTAWPDHGVPEY 1563
            ++G  TYG I+V + D + L  + +R F +     +G    R V Q  FT+WPD GVP  
Sbjct: 250  DQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFT 309

Query: 1564 PTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTL 1623
            P   L FL++VKT NP  AGPIVVHCSAGVGRTG FIVIDAM+  +  E+ VDV+  V+ 
Sbjct: 310  PIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSR 369

Query: 1624 MRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELE 1683
            +R+QR  MVQT+ QY+FI++ALLE    G+TE+   SL  ++Q +          G+E E
Sbjct: 370  IRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEE 429

Query: 1684 FKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDG 1743
            F++L N +       + NLP N  K R++ I+PY+  RV L   RG E +DYINASFIDG
Sbjct: 430  FRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDG 489

Query: 1744 YRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQ 1803
            YRQ+  +IATQGPLA T EDFWRM+WE  S  +VMLT+++E  ++KC+QYWP E S  + 
Sbjct: 490  YRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHG 549

Query: 1804 YFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTVRQFQFTDWPEQGVPKSGEGFID 1858
               ++   +       +R+F VT       ++ Q R VRQF F  WPE G+P  G+G ID
Sbjct: 550  EITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMID 609

Query: 1859 FIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQ 1918
             I  V K ++Q G + PI+VHCSAG GRTG FI LS +LER++ EG++D+FQ VK LR Q
Sbjct: 610  LIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQ 668

Query: 1919 RPAMVQTEDEYQFCYQAALEYLGSFDHYA 1947
            RP MVQT ++Y+FCY+   +++  F  YA
Sbjct: 669  RPHMVQTLEQYEFCYKVVQDFIDIFSDYA 697


>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
            [Homo sapiens]
          Length = 642

 Score =  549 bits (1414), Expect = e-155
 Identities = 283/585 (48%), Positives = 381/585 (65%), Gaps = 10/585 (1%)

Query: 1372 PIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDH 1430
            PIP+  + E      A+D  +  +E+ S+  G  Q T+E +N E N+ KNRY N++  DH
Sbjct: 56   PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDH 115

Query: 1431 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1490
            SRVIL  ++GI  SDYINA+Y+DGY+ +N +IA QGP  ET  DFWRMVWEQ+SATIVM+
Sbjct: 116  SRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML 175

Query: 1491 TRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHK---NGSSEKREV 1547
            T L+E+   KC QYWP++G  TYG I+V + D + L  + +R F +     +G    R V
Sbjct: 176  TNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLV 235

Query: 1548 RQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1607
             Q  FT+WPD GVP  P   L FL++VKT NP  AGPIVVHCSAGVGRTG FIVIDAM+ 
Sbjct: 236  SQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMA 295

Query: 1608 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQK 1667
             +  E+ VDV+  V+ +R+QR  MVQT+ QY+FI++ALLE    G+TE+   SL  ++Q 
Sbjct: 296  MMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQT 355

Query: 1668 LAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1727
            +          G+E EF++L N +       + NLP N  K R++ I+PY+  RV L   
Sbjct: 356  MHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMK 415

Query: 1728 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGR 1787
            RG E +DYINASFIDGYRQ+  +IATQGPLA T EDFWRM+WE  S  +VMLT+++E  +
Sbjct: 416  RGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQ 475

Query: 1788 EKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTVRQFQFT 1842
            +KC+QYWP E S  +    ++   +       +R+F VT       ++ Q R VRQF F 
Sbjct: 476  DKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFH 535

Query: 1843 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1902
             WPE G+P  G+G ID I  V K ++Q G + PI+VHCSAG GRTG FI LS +LER++ 
Sbjct: 536  GWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNILERVKA 594

Query: 1903 EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA 1947
            EG++D+FQ VK LR QRP MVQT ++Y+FCY+   +++  F  YA
Sbjct: 595  EGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639


>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
            [Homo sapiens]
          Length = 1440

 Score =  516 bits (1330), Expect = e-146
 Identities = 352/994 (35%), Positives = 514/994 (51%), Gaps = 124/994 (12%)

Query: 1033 DQVSPKNFKVKMIMKTS----VLLSWEFPDNYNSP-TPYKIQYNGL-------------- 1073
            D+  P    VK +  TS    + L+W+ P + N   T Y+I Y+ +              
Sbjct: 486  DEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQ 545

Query: 1074 TLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPD 1133
            T+     +T  +  HL P T Y F +  R S++ G           N+     S    PD
Sbjct: 546  TVSNLWNSTHHVFMHLHPGTTYQFFI--RASTVKGFGPATAINVTTNI-----SAPTLPD 598

Query: 1134 ADGF----------IMVYLPDGQSP-VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLE 1182
             +G           I V L   Q+   P+ +Y IV+  L   R  +     G+ E   + 
Sbjct: 599  YEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKR---EAGAMECYQVP 655

Query: 1183 ELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPP-------TFHPGDQKQYGGFDNRG 1235
               Q+              +    PY  A  + LPP        F  GD + Y GF N  
Sbjct: 656  VTYQNA-------------MSGGAPYYFA--AELPPGNLPEPAPFTVGDNRTYQGFWNPP 700

Query: 1236 LEPGHRYVLFVLAVLQKSEPTFA--------ASPFSDPFQLDNPDPQPIVDGEEGLIWVI 1287
            L P   Y ++  A+    + T          A+   +P  +  PDP    D    +  + 
Sbjct: 701  LAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI--PDPAKQTDRVVKIAGIS 758

Query: 1288 GPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN---------ADLAPHHPKDP 1338
              +L  + ++ +VI +++ K+K   KRKD+   T+  + +         AD +  H +DP
Sbjct: 759  AGILVFILLLLVVI-LIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDP 817

Query: 1339 VE---MRRINFQ--------TPDS------------GLRSPLREPGFHFESMLSHPPIPI 1375
            +    M + NF         T +S            G  SP       +++   HP I +
Sbjct: 818  LSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP-------YQTGQLHPAIRV 870

Query: 1376 ADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVIL 1435
            AD+ +H   +K +DS    +EYES   GQ  +W+ +  + N+ KNRY N+IAYDHSRVIL
Sbjct: 871  ADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVIL 930

Query: 1436 QPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEE 1495
            QP+E    SDYINANY+DGY+  + YIATQGP+ ET  DFWRM+W+++SA IVM+T L E
Sbjct: 931  QPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVE 990

Query: 1496 KSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAW 1555
              R+KC +YWP+  TE YG  +VT ++   LA + VRTF+L + G +E REV+QF FT W
Sbjct: 991  VGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGW 1049

Query: 1556 PDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTV 1615
            PDHGVP + T  L+F+RRVK  NPP AGPIVVHCSAG GRTGC+IVID ML+  + E  V
Sbjct: 1050 PDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVV 1109

Query: 1616 DVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGE 1675
            D+Y  V  +RS+R  MVQTE+QY FIH+A+LEA  CG T +P     A    + +++   
Sbjct: 1110 DIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQT 1169

Query: 1676 HVTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS 1733
            + + ++ EF+ L     +        A LP N  KNR ++++P +     L  I G E S
Sbjct: 1170 NSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESS 1228

Query: 1734 DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQY 1793
            +YINA+ +D YRQ  A+I TQ PL  T +DFWR++++   T +VML ++     + C QY
Sbjct: 1229 NYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQY 1286

Query: 1794 WPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQSRTVRQFQFTDW-PEQGV 1849
            WP E   RY    V+ M+   + ++   I R   +T  ++G    V+QFQ+  W   + V
Sbjct: 1287 WPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY-LMVQQFQYLGWASHREV 1345

Query: 1850 PKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDI 1908
            P S   F+  I QV K +E+  + +G   +HC  G GR+G+F  + IV+E ++ + VVD+
Sbjct: 1346 PGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDV 1405

Query: 1909 FQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1942
            F  VK LR  +P MV+  ++Y+FCY  ALEYL S
Sbjct: 1406 FHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 100/450 (22%), Positives = 167/450 (37%), Gaps = 70/450 (15%)

Query: 255 EIMPGGNVNITCVAVGSPMPYVK-WMQGAEDLTPEDDMPVG--RNV----------LELT 301
           E+  G N    C+A G    + K W+Q        +D+PV   +N+          L+  
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRNG----EDIPVAQTKNINHRRFAASFRLQEV 260

Query: 302 DVKDSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---P 357
              D   Y CV  S  G  +   AQ+ V+  P+    P +     T + I  ++ +    
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320

Query: 358 DPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSE 415
            P+    +EY+  S  G +     +    Y +  L P++EYEI V  +     G G P  
Sbjct: 321 GPIILKEVEYRMTS--GSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378

Query: 416 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRV--YYTMEPEHPVG 473
            ++TRT    P   P+ ++   + A  + V WE          GY +   +T        
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430

Query: 474 NWQKHN--------VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP 525
            ++ HN        +D      V + L   T     +  T+      S+   ++T + VP
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP 490

Query: 526 GQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP------- 575
           G  P+        E  I L+W  P   +  I +YE+ +          R+FDP       
Sbjct: 491 GPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSS-------IRSFDPAVPVAGP 543

Query: 576 ---------TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVK 626
                    +T +V   L P T Y F + A + +G G  T  +   T  S P+ P  +  
Sbjct: 544 PQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPAT-AINVTTNISAPTLPDYEGV 602

Query: 627 CVSVRSTAILVSWRPPPPETHNGALVGYSV 656
             S+  TA  ++    P +     +  Y +
Sbjct: 603 DASLNETATTITVLLRPAQAKGAPISAYQI 632



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 62/277 (22%), Positives = 104/277 (37%), Gaps = 23/277 (8%)

Query: 578 SYVVEDLKPNTEYAFRLAARSPQ--GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAI 635
           +Y +  L P+TEY  R+    P   G G   P +  RT  ++P   P+ +K   +++  I
Sbjct: 347 TYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRI 406

Query: 636 LVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRIT 695
            V W               ++ Y      +    +   + P   Q ++  L  +T   + 
Sbjct: 407 AVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLK 466

Query: 696 TVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRG 755
            +     G   ES   +++TDEDVP   P K          I + W+ P     +G I  
Sbjct: 467 MILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLD--PNGIITQ 523

Query: 756 YQVHYVRMEGAE----ARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAA 811
           Y++ Y  +   +      GPP+    +     W +        V  +L P T Y   + A
Sbjct: 524 YEISYSSIRSFDPAVPVAGPPQTVSNL-----WNST-----HHVFMHLHPGTTYQFFIRA 573

Query: 812 YTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSL 848
            T+KG G    P   +     +  PTL   +  + SL
Sbjct: 574 STVKGFG----PATAINVTTNISAPTLPDYEGVDASL 606



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 67/334 (20%), Positives = 119/334 (35%), Gaps = 37/334 (11%)

Query: 712  VVRTDEDVPSAPPRKVEAEALNATAIRVLWRSP---APGRQHGQIRGYQVHYVRMEGAEA 768
            V +TD+D+     +      ++  A  ++   P   AP +  G    Y +  +       
Sbjct: 260  VTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIG 319

Query: 769  RGPPRIKDV---MLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKV 825
             GP  +K+V   M + +  ET         + +L P+T Y I V   T  G+G    P  
Sbjct: 320  DGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLL-TRPGEGGTGLPGP 378

Query: 826  VVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQ-------------FGR 872
             +        P     +TP+   +A  +      + + LGY +              F  
Sbjct: 379  PLITRTKCAEP----MRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRG 434

Query: 873  EDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHP 932
             + +    L+  P   ++  + +        ++   +  G  E    ++   ED P G  
Sbjct: 435  HNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP-GPV 493

Query: 933  QILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAE 992
             +    G +    + L W  P+  + NG I +Y ++     +  PA    +P A  P   
Sbjct: 494  PVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYSSIRSFDPA----VPVAGPPQTV 547

Query: 993  NAL------TLQGLKPDTAYDLQVRAHTRRGPGP 1020
            + L          L P T Y   +RA T +G GP
Sbjct: 548  SNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP 581



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 53/248 (21%), Positives = 96/248 (38%), Gaps = 20/248 (8%)

Query: 333 KAPGTPMVTENTATSITITWDSGNPDPVSYYVIE-------YKSKSQDGPYQIKEDITTT 385
           + P T  + E  A  I + W+S   +    +          ++  ++     +  D    
Sbjct: 391 RTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAP 450

Query: 386 RYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIV 445
           ++ +  L P +   + +   N  G+   SE  + +T E  P   P            + +
Sbjct: 451 QHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFL 509

Query: 446 QWEEPVEPNGLIRGYRVYY----TMEPEHPVGNWQK--HNVDDSLLTTVGSLLEDETYTV 499
            W+EP++PNG+I  Y + Y    + +P  PV    +   N+ +S       L    TY  
Sbjct: 510 NWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQF 569

Query: 500 RVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA---RSETSITLSWSPPRQES--II 554
            + A T  G GP +  I V T    P  P     +A    + T+IT+   P + +   I 
Sbjct: 570 FIRASTVKGFGP-ATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPIS 628

Query: 555 KYELLFRE 562
            Y+++  E
Sbjct: 629 AYQIVVEE 636



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 104/431 (24%), Positives = 159/431 (36%), Gaps = 68/431 (15%)

Query: 578 SYVVEDLKPNTEYAFRLAARSPQGLGAFT---PVVRQRTLQSKPSAPPQDVKCVSVRSTA 634
           S+ ++++    +  +R   +S +G G       +VR+     +P APPQ    + V  T 
Sbjct: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE---PPRPIAPPQ---LLGVGPTY 307

Query: 635 ILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQY-- 692
           +L+          +G ++   V YR       E   VN   PT     L  L+  T+Y  
Sbjct: 308 LLIQLNANSI-IGDGPIILKEVEYRMTSGSWTETHAVNA--PTYK---LWHLDPDTEYEI 361

Query: 693 RITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPG--RQH 750
           R+      E G G    P++ RT    P   P+ ++   + A  I V W S      R H
Sbjct: 362 RVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCH 421

Query: 751 GQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVA 810
                   HY R                 + A     D    + V+ +L P T  S+ + 
Sbjct: 422 TFNVTICYHYFRGHNE-------------SKADCLDMDPKAPQHVVNHLPPYTNVSLKMI 468

Query: 811 AYTMKGDGARSKPKVVVTKGAVLGR-PTLSVQQTP-EGSLLARW-EP--PAGTAEDQVLG 865
               +G    S+  ++ T   V G  P  S+Q T  E  +   W EP  P G      + 
Sbjct: 469 LTNPEG-RKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEIS 527

Query: 866 YRLQFGREDSTPLA----TLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVL 921
           Y      + + P+A    T+    +   +    +H G TY F + A +  G G   A   
Sbjct: 528 YSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA--- 584

Query: 922 SIPEDTPRGHPQILEAAG-------NASAGTVLLRWLPPVPAERNGA-IVKYTVAV---- 969
            I   T    P + +  G        A+  TVLLR     PA+  GA I  Y + V    
Sbjct: 585 -INVTTNISAPTLPDYEGVDASLNETATTITVLLR-----PAQAKGAPISAYQIVVEELH 638

Query: 970 -----REAGAL 975
                REAGA+
Sbjct: 639 PHRTKREAGAM 649



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 38/134 (28%), Positives = 57/134 (42%), Gaps = 21/134 (15%)

Query: 988  EPGAENALT--LQGLKPDTAYDLQVRAHTRRGPGPFS---PPVRYRTFLRDQV-SPKNFK 1041
            E  A NA T  L  L PDT Y+++V   TR G G      PP+  RT   + + +PK  K
Sbjct: 339  ETHAVNAPTYKLWHLDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLK 397

Query: 1042 VKMIMKTSVLLSWEFPD-------NYNSPTPYKI-----QYNGLTLDVDGRTTKKLITHL 1089
            +  I    + + WE           +N    Y       +     LD+D +  + ++ HL
Sbjct: 398  IAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHL 457

Query: 1090 KPHT--FYNFVLTN 1101
             P+T      +LTN
Sbjct: 458  PPYTNVSLKMILTN 471



 Score = 32.3 bits (72), Expect = 4.6
 Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%)

Query: 30  EEPPRFIKEPKDQIGVSGGVASFVCQATG-DPKPRVTW--NKKGKKVNSQRFETIEFDES 86
           ++ P F++    ++  +G  A+F C ATG D      W   + G+ +   + + I     
Sbjct: 193 DKSPHFLRLGDVEVN-AGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRF 251

Query: 87  AGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPN-IDMGPQLKV 145
           A A  R+Q + T  D+++Y CV Q+  G    +    ++RE   P   P  + +GP   +
Sbjct: 252 A-ASFRLQEV-TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLL 309

Query: 146 VE 147
           ++
Sbjct: 310 IQ 311


>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
            [Homo sapiens]
          Length = 1446

 Score =  510 bits (1313), Expect = e-144
 Identities = 352/1000 (35%), Positives = 514/1000 (51%), Gaps = 130/1000 (13%)

Query: 1033 DQVSPKNFKVKMIMKTS----VLLSWEFPDNYNSP-TPYKIQYNGL-------------- 1073
            D+  P    VK +  TS    + L+W+ P + N   T Y+I Y+ +              
Sbjct: 486  DEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQ 545

Query: 1074 TLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPD 1133
            T+     +T  +  HL P T Y F +  R S++ G           N+     S    PD
Sbjct: 546  TVSNLWNSTHHVFMHLHPGTTYQFFI--RASTVKGFGPATAINVTTNI-----SAPTLPD 598

Query: 1134 ADGF----------IMVYLPDGQSP-VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLE 1182
             +G           I V L   Q+   P+ +Y IV+  L   R  +     G+ E   + 
Sbjct: 599  YEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKR---EAGAMECYQVP 655

Query: 1183 ELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPP-------TFHPGDQKQYGGFDNRG 1235
               Q+              +    PY  A  + LPP        F  GD + Y GF N  
Sbjct: 656  VTYQNA-------------MSGGAPYYFA--AELPPGNLPEPAPFTVGDNRTYQGFWNPP 700

Query: 1236 LEPGHRYVLFVLAVLQKSEPTFA--------ASPFSDPFQLDNPDPQPIVDGEEGLIWVI 1287
            L P   Y ++  A+    + T          A+   +P  +  PDP    D    +  + 
Sbjct: 701  LAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI--PDPAKQTDRVVKIAGIS 758

Query: 1288 GPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN---------ADLAPHHPKDP 1338
              +L  + ++ +VI +++ K+K   KRKD+   T+  + +         AD +  H +DP
Sbjct: 759  AGILVFILLLLVVI-LIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDP 817

Query: 1339 VE---MRRINFQ--------TPDS------------GLRSPLREPGFHFESMLSHPPIPI 1375
            +    M + NF         T +S            G  SP       +++   HP I +
Sbjct: 818  LSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESP-------YQTGQLHPAIRV 870

Query: 1376 ADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVIL 1435
            AD+ +H   +K +DS    +EYES   GQ  +W+ +  + N+ KNRY N+IAYDHSRVIL
Sbjct: 871  ADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVIL 930

Query: 1436 QPIEGIMGSDYINANYVD------GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVM 1489
            QP+E    SDYINANY+D      GY+  + YIATQGP+ ET  DFWRM+W+++SA IVM
Sbjct: 931  QPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVM 990

Query: 1490 MTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1549
            +T L E  R+KC +YWP+  TE YG  +VT ++   LA + VRTF+L + G +E REV+Q
Sbjct: 991  VTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQ 1049

Query: 1550 FQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI 1609
            F FT WPDHGVP + T  L+F+RRVK  NPP AGPIVVHCSAG GRTGC+IVID ML+  
Sbjct: 1050 FHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMA 1109

Query: 1610 KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA 1669
            + E  VD+Y  V  +RS+R  MVQTE+QY FIH+A+LEA  CG T +P     A    + 
Sbjct: 1110 EREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMI 1169

Query: 1670 QVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1727
            +++   + + ++ EF+ L     +        A LP N  KNR ++++P +     L  I
Sbjct: 1170 RIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITI 1229

Query: 1728 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGR 1787
             G E S+YINA+ +D YRQ  A+I TQ PL  T +DFWR++++   T +VML ++     
Sbjct: 1230 DG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--S 1286

Query: 1788 EKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1844
            + C QYWP E   RY    V+ M+   + ++   I R   +T  ++G    V+QFQ+  W
Sbjct: 1287 QGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY-LMVQQFQYLGW 1345

Query: 1845 -PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVFITLSIVLERMRY 1902
               + VP S   F+  I QV K +E+  + +G   +HC  G GR+G+F  + IV+E ++ 
Sbjct: 1346 ASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKR 1405

Query: 1903 EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1942
            + VVD+F  VK LR  +P MV+  ++Y+FCY  ALEYL S
Sbjct: 1406 QNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 100/450 (22%), Positives = 167/450 (37%), Gaps = 70/450 (15%)

Query: 255 EIMPGGNVNITCVAVGSPMPYVK-WMQGAEDLTPEDDMPVG--RNV----------LELT 301
           E+  G N    C+A G    + K W+Q        +D+PV   +N+          L+  
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRNG----EDIPVAQTKNINHRRFAASFRLQEV 260

Query: 302 DVKDSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---P 357
              D   Y CV  S  G  +   AQ+ V+  P+    P +     T + I  ++ +    
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320

Query: 358 DPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSE 415
            P+    +EY+  S  G +     +    Y +  L P++EYEI V  +     G G P  
Sbjct: 321 GPIILKEVEYRMTS--GSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378

Query: 416 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRV--YYTMEPEHPVG 473
            ++TRT    P   P+ ++   + A  + V WE          GY +   +T        
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430

Query: 474 NWQKHN--------VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP 525
            ++ HN        +D      V + L   T     +  T+      S+   ++T + VP
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP 490

Query: 526 GQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP------- 575
           G  P+        E  I L+W  P   +  I +YE+ +          R+FDP       
Sbjct: 491 GPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSS-------IRSFDPAVPVAGP 543

Query: 576 ---------TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVK 626
                    +T +V   L P T Y F + A + +G G  T  +   T  S P+ P  +  
Sbjct: 544 PQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPAT-AINVTTNISAPTLPDYEGV 602

Query: 627 CVSVRSTAILVSWRPPPPETHNGALVGYSV 656
             S+  TA  ++    P +     +  Y +
Sbjct: 603 DASLNETATTITVLLRPAQAKGAPISAYQI 632



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 62/277 (22%), Positives = 104/277 (37%), Gaps = 23/277 (8%)

Query: 578 SYVVEDLKPNTEYAFRLAARSPQ--GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAI 635
           +Y +  L P+TEY  R+    P   G G   P +  RT  ++P   P+ +K   +++  I
Sbjct: 347 TYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRI 406

Query: 636 LVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRIT 695
            V W               ++ Y      +    +   + P   Q ++  L  +T   + 
Sbjct: 407 AVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLK 466

Query: 696 TVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRG 755
            +     G   ES   +++TDEDVP   P K          I + W+ P     +G I  
Sbjct: 467 MILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLD--PNGIITQ 523

Query: 756 YQVHYVRMEGAE----ARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAA 811
           Y++ Y  +   +      GPP+    +     W +        V  +L P T Y   + A
Sbjct: 524 YEISYSSIRSFDPAVPVAGPPQTVSNL-----WNST-----HHVFMHLHPGTTYQFFIRA 573

Query: 812 YTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSL 848
            T+KG G    P   +     +  PTL   +  + SL
Sbjct: 574 STVKGFG----PATAINVTTNISAPTLPDYEGVDASL 606



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 67/334 (20%), Positives = 119/334 (35%), Gaps = 37/334 (11%)

Query: 712  VVRTDEDVPSAPPRKVEAEALNATAIRVLWRSP---APGRQHGQIRGYQVHYVRMEGAEA 768
            V +TD+D+     +      ++  A  ++   P   AP +  G    Y +  +       
Sbjct: 260  VTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIG 319

Query: 769  RGPPRIKDV---MLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKV 825
             GP  +K+V   M + +  ET         + +L P+T Y I V   T  G+G    P  
Sbjct: 320  DGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLL-TRPGEGGTGLPGP 378

Query: 826  VVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQ-------------FGR 872
             +        P     +TP+   +A  +      + + LGY +              F  
Sbjct: 379  PLITRTKCAEP----MRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRG 434

Query: 873  EDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHP 932
             + +    L+  P   ++  + +        ++   +  G  E    ++   ED P G  
Sbjct: 435  HNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP-GPV 493

Query: 933  QILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAE 992
             +    G +    + L W  P+  + NG I +Y ++     +  PA    +P A  P   
Sbjct: 494  PVKSLQGTSFENKIFLNWKEPL--DPNGIITQYEISYSSIRSFDPA----VPVAGPPQTV 547

Query: 993  NAL------TLQGLKPDTAYDLQVRAHTRRGPGP 1020
            + L          L P T Y   +RA T +G GP
Sbjct: 548  SNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGP 581



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 53/248 (21%), Positives = 96/248 (38%), Gaps = 20/248 (8%)

Query: 333 KAPGTPMVTENTATSITITWDSGNPDPVSYYVIE-------YKSKSQDGPYQIKEDITTT 385
           + P T  + E  A  I + W+S   +    +          ++  ++     +  D    
Sbjct: 391 RTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAP 450

Query: 386 RYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIV 445
           ++ +  L P +   + +   N  G+   SE  + +T E  P   P            + +
Sbjct: 451 QHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFL 509

Query: 446 QWEEPVEPNGLIRGYRVYY----TMEPEHPVGNWQK--HNVDDSLLTTVGSLLEDETYTV 499
            W+EP++PNG+I  Y + Y    + +P  PV    +   N+ +S       L    TY  
Sbjct: 510 NWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQF 569

Query: 500 RVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA---RSETSITLSWSPPRQES--II 554
            + A T  G GP +  I V T    P  P     +A    + T+IT+   P + +   I 
Sbjct: 570 FIRASTVKGFGP-ATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPIS 628

Query: 555 KYELLFRE 562
            Y+++  E
Sbjct: 629 AYQIVVEE 636



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 104/431 (24%), Positives = 159/431 (36%), Gaps = 68/431 (15%)

Query: 578 SYVVEDLKPNTEYAFRLAARSPQGLGAFT---PVVRQRTLQSKPSAPPQDVKCVSVRSTA 634
           S+ ++++    +  +R   +S +G G       +VR+     +P APPQ    + V  T 
Sbjct: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE---PPRPIAPPQ---LLGVGPTY 307

Query: 635 ILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQY-- 692
           +L+          +G ++   V YR       E   VN   PT     L  L+  T+Y  
Sbjct: 308 LLIQLNANSI-IGDGPIILKEVEYRMTSGSWTETHAVNA--PTYK---LWHLDPDTEYEI 361

Query: 693 RITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPG--RQH 750
           R+      E G G    P++ RT    P   P+ ++   + A  I V W S      R H
Sbjct: 362 RVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCH 421

Query: 751 GQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVA 810
                   HY R                 + A     D    + V+ +L P T  S+ + 
Sbjct: 422 TFNVTICYHYFRGHNE-------------SKADCLDMDPKAPQHVVNHLPPYTNVSLKMI 468

Query: 811 AYTMKGDGARSKPKVVVTKGAVLGR-PTLSVQQTP-EGSLLARW-EP--PAGTAEDQVLG 865
               +G    S+  ++ T   V G  P  S+Q T  E  +   W EP  P G      + 
Sbjct: 469 LTNPEG-RKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEIS 527

Query: 866 YRLQFGREDSTPLA----TLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVL 921
           Y      + + P+A    T+    +   +    +H G TY F + A +  G G   A   
Sbjct: 528 YSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA--- 584

Query: 922 SIPEDTPRGHPQILEAAG-------NASAGTVLLRWLPPVPAERNGA-IVKYTVAV---- 969
            I   T    P + +  G        A+  TVLLR     PA+  GA I  Y + V    
Sbjct: 585 -INVTTNISAPTLPDYEGVDASLNETATTITVLLR-----PAQAKGAPISAYQIVVEELH 638

Query: 970 -----REAGAL 975
                REAGA+
Sbjct: 639 PHRTKREAGAM 649



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 38/134 (28%), Positives = 57/134 (42%), Gaps = 21/134 (15%)

Query: 988  EPGAENALT--LQGLKPDTAYDLQVRAHTRRGPGPFS---PPVRYRTFLRDQV-SPKNFK 1041
            E  A NA T  L  L PDT Y+++V   TR G G      PP+  RT   + + +PK  K
Sbjct: 339  ETHAVNAPTYKLWHLDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLK 397

Query: 1042 VKMIMKTSVLLSWEFPD-------NYNSPTPYKI-----QYNGLTLDVDGRTTKKLITHL 1089
            +  I    + + WE           +N    Y       +     LD+D +  + ++ HL
Sbjct: 398  IAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHL 457

Query: 1090 KPHT--FYNFVLTN 1101
             P+T      +LTN
Sbjct: 458  PPYTNVSLKMILTN 471



 Score = 32.3 bits (72), Expect = 4.6
 Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%)

Query: 30  EEPPRFIKEPKDQIGVSGGVASFVCQATG-DPKPRVTW--NKKGKKVNSQRFETIEFDES 86
           ++ P F++    ++  +G  A+F C ATG D      W   + G+ +   + + I     
Sbjct: 193 DKSPHFLRLGDVEVN-AGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRF 251

Query: 87  AGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPN-IDMGPQLKV 145
           A A  R+Q + T  D+++Y CV Q+  G    +    ++RE   P   P  + +GP   +
Sbjct: 252 A-ASFRLQEV-TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLL 309

Query: 146 VE 147
           ++
Sbjct: 310 IQ 311


>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
            precursor [Homo sapiens]
          Length = 1452

 Score =  505 bits (1301), Expect = e-142
 Identities = 351/981 (35%), Positives = 492/981 (50%), Gaps = 116/981 (11%)

Query: 1050 VLLSWEFP-DNYNSPTPYKIQYNGLTL---DVD-----------GRTTKKLITHLKPHTF 1094
            + L W  P   Y   T Y+I Y  ++    ++D           G  T  L   L P T 
Sbjct: 499  IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTT 558

Query: 1095 YNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQSP 1148
            Y+F +  R S+  G     T    F      PS+       P    D  + V L    S 
Sbjct: 559  YSFTI--RASTAKGFGPPAT--NQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614

Query: 1149 -VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRP 1207
              PV  Y IV+   R  R         + +  ++ +        Q  SL +S+       
Sbjct: 615  GAPVSVYQIVVEEERPRR---------TKKTTEILKCYPVPIHFQNASLLNSQY------ 659

Query: 1208 YIAARFSV----LPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT------F 1257
            Y AA F          F  GD K Y G+ N  L P   Y ++  A  + +  T       
Sbjct: 660  YFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQV 719

Query: 1258 AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS 1317
            A    + P  +  P+P+   D    +  VI  +L  V II + + +++ K K   KRK++
Sbjct: 720  ATKGAATPKPV--PEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKET 776

Query: 1318 --------------------EPRTKC-----LLNNADLAPHHPKDP----VEMRRINFQT 1348
                                E  T C      ++  +L       P    ++   ++   
Sbjct: 777  MSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSV 836

Query: 1349 PDSGLRSPL------------------REPG-FHFESMLSHPPIPIADMAEHTERLKAND 1389
            P+S                        REP    +++   HP I +AD+ +H  ++K  +
Sbjct: 837  PNSYYPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAE 896

Query: 1390 SLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINA 1449
                 +EYES   GQ   W+ +  + N+ KNRY N+IAYDHSRV LQ IEG   SDYIN 
Sbjct: 897  GYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYING 956

Query: 1450 NYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG 1509
            NY+DGY   N YIATQGP+ ET  DFWRMVW + +A+I+M+T L E  R+KC +YWP+  
Sbjct: 957  NYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD-D 1015

Query: 1510 TETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLA 1569
            TE Y  I+VTL++T  LA + +RTF++ K G  E RE+RQF FT WPDHGVP + T  L 
Sbjct: 1016 TEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLG 1075

Query: 1570 FLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRN 1629
            F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+  + E  VD+Y  V  +RS+R 
Sbjct: 1076 FVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRV 1135

Query: 1630 YMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLAN 1689
             MVQTE+QY FIH+A+LEA  CG+T VPA  + +    + +++P  + + ++ EF+ L N
Sbjct: 1136 NMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTL-N 1194

Query: 1690 SKAHTSRFIS---ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQ 1746
                T R      A LP N  KNR ++I+P +     L  I G E S+YINA+ +D Y+Q
Sbjct: 1195 MVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQ 1253

Query: 1747 QKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP---AERSARYQ 1803
              A+I TQ PL  T +DFWR++ + + T VVML  +     + C QYWP     R    Q
Sbjct: 1254 PSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQ 1311

Query: 1804 YFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQ 1862
               V    E ++   I R +     +DG  R V+QFQF  WP  +  P S   F+  I Q
Sbjct: 1312 VEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQ 1370

Query: 1863 VHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPA 1921
            V K +E++ G +G   VHC  G GR+G F  +SIV E +R++  VD+F  VK LR  +P 
Sbjct: 1371 VDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPN 1430

Query: 1922 MVQTEDEYQFCYQAALEYLGS 1942
            MV   D+Y+FCY+ ALEYL S
Sbjct: 1431 MVDLLDQYKFCYEVALEYLNS 1451



 Score =  133 bits (334), Expect = 2e-30
 Identities = 83/243 (34%), Positives = 120/243 (49%), Gaps = 9/243 (3%)

Query: 1416 NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDF 1475
            N  KNR  +++  D     L  I+G   S+YINA  +D Y+  +A+I TQ PLP T  DF
Sbjct: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271

Query: 1476 WRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFS 1535
            WR+V +    ++VM+  ++      C QYWP  G   +G IQV  +          R F 
Sbjct: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329

Query: 1536 LHKNGSSEK--REVRQFQFTAWPDH-GVPEYPTPFLAFLRRVKTCNPP---DAGPIVVHC 1589
            ++     +   R V+QFQF  WP +   P     FL  +R+V           G  VVHC
Sbjct: 1330 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1389

Query: 1590 SAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1649
              G GR+G F  I  + E ++ ++TVDV+  V  +R+ +  MV   DQY F +E  LE +
Sbjct: 1390 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1449

Query: 1650 GCG 1652
              G
Sbjct: 1450 NSG 1452



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 100/408 (24%), Positives = 172/408 (42%), Gaps = 44/408 (10%)

Query: 255 EIMPGGNVNITCVAVGSPMPYVK-WMQGAE---------DLTPEDDMPVGRNVLELTDVK 304
           E+  G      C A+G  +   + W+QG +          +T         NV+  T  +
Sbjct: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK-R 253

Query: 305 DSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPD---PV 360
           D+  Y C+  +  GV I   A++ VK  P     P +    AT + I  ++ + +   P+
Sbjct: 254 DAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPI 313

Query: 361 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVV 418
               +EY + S  G +  ++ + +T Y IG L P++EYEI V  +     G G P  ++ 
Sbjct: 314 VAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALR 371

Query: 419 TRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKH 478
           TRT    P   PR ++   + +  + ++W EP   N + R +    T+   + VG  ++ 
Sbjct: 372 TRTKCADPMRGPRKLEVVEVKSRQITIRW-EPFGYN-VTRCHSYNLTVHYCYQVGGQEQV 429

Query: 479 NVDDSLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMN 530
             + S  T       T+ +L      +V+++     G    S  + V+T + +PG  P  
Sbjct: 430 REEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTE 488

Query: 531 LRAEARSETSITLSWSPPRQE--SIIKYELLFR-------EGDHGREVGRT--FDPTTSY 579
               +  E  I L W  P Q    I  YE+ ++       E D   + GR       T +
Sbjct: 489 SIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHF 548

Query: 580 VVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ-SKPSAPPQDVK 626
           +   L P T Y+F + A + +G G   P   Q T + S PS P  +++
Sbjct: 549 LFFGLYPGTTYSFTIRASTAKGFG--PPATNQFTTKISAPSMPAYELE 594



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 63/248 (25%), Positives = 105/248 (42%), Gaps = 15/248 (6%)

Query: 576 TTSYVVEDLKPNTEYAFRLAARSPQ--GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRST 633
           +TSY +  L P+TEY   +    P   G G+  P +R RT  + P   P+ ++ V V+S 
Sbjct: 335 STSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSR 394

Query: 634 AILVSWRPPPPETHNGALVGYSVRY-RPLGSEDPEPKEVN-GIPPTTTQILLEALEKWTQ 691
            I + W P             +V Y   +G ++   +EV+     +  Q  +  L  +T 
Sbjct: 395 QITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTN 454

Query: 692 YRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHG 751
             +  +     G   ES  ++V+TDED+P A P +    +     I + WR P   + +G
Sbjct: 455 VSVKLILMNPEG-RKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYG 511

Query: 752 QIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTA-EYEMVITNLQPETAYSITVA 810
            I  Y++ Y  +   +        ++ L++          E   +   L P T YS T+ 
Sbjct: 512 VITLYEITYKAVSSFD-------PEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIR 564

Query: 811 AYTMKGDG 818
           A T KG G
Sbjct: 565 ASTAKGFG 572



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 78/326 (23%), Positives = 125/326 (38%), Gaps = 35/326 (10%)

Query: 675 PPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSP---VVVRTDEDVPSAPPRKVEAEA 731
           P  +T   +  L+  T+Y I+ +  T  G G   SP   +  RT    P   PRK+E   
Sbjct: 332 PVDSTSYKIGHLDPDTEYEISVLL-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVE 390

Query: 732 LNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAE 791
           + +  I + W                VHY    G    G  ++++    +  W+T+++  
Sbjct: 391 VKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVG----GQEQVRE----EVSWDTENSHP 442

Query: 792 YEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTK-----GAVLGRPTLSVQ-QTPE 845
            +  ITNL P T  +++V    M  +G +   +++V       GAV   PT S+Q  T E
Sbjct: 443 -QHTITNLSPYT--NVSVKLILMNPEGRKESQELIVQTDEDLPGAV---PTESIQGSTFE 496

Query: 846 GSLLARWEPPA---GTAEDQVLGYRLQFGREDSTPLATLEFPPS----EDRYTASGVHKG 898
             +  +W  P    G      + Y+     +    L+      S    E  +   G++ G
Sbjct: 497 EKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPG 556

Query: 899 ATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAER 958
            TY F + A +  G G  A    +     P      LE   N +  TV +      PA  
Sbjct: 557 TTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVML---KPAHS 613

Query: 959 NGAIVK-YTVAVREAGALGPARETEL 983
            GA V  Y + V E       + TE+
Sbjct: 614 RGAPVSVYQIVVEEERPRRTKKTTEI 639



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 79/341 (23%), Positives = 121/341 (35%), Gaps = 51/341 (14%)

Query: 700  TEVGPGPESSPVVVRTDEDVPSAPPRKVEAEA------LNATAIRVLWRSPAPGRQHGQI 753
            TE G G  +   +V  +  VP APP+     A      LNA +I             G I
Sbjct: 264  TEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSIN----------GDGPI 313

Query: 754  RGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYT 813
               +V Y    G+     P               D+  Y+  I +L P+T Y I+V   T
Sbjct: 314  VAREVEYCTASGSWNDRQPV--------------DSTSYK--IGHLDPDTEYEISVLL-T 356

Query: 814  MKGDGARSKPKVVV---TKGA--VLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRL 868
              G+G    P   +   TK A  + G   L V +     +  RWEP  G    +   Y L
Sbjct: 357  RPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEP-FGYNVTRCHSYNL 415

Query: 869  QF-------GREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVL 921
                     G+E      + +   S  ++T + +        +L   +  G  E    ++
Sbjct: 416  TVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIV 475

Query: 922  SIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARE- 980
               ED P   P      G+     + L+W  P   +  G I  Y +  +   +  P  + 
Sbjct: 476  QTDEDLPGAVPTE-SIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEIDL 532

Query: 981  -TELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGP 1020
              +    ++ G E      GL P T Y   +RA T +G GP
Sbjct: 533  SNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGP 573


>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
            precursor [Homo sapiens]
          Length = 1465

 Score =  497 bits (1280), Expect = e-140
 Identities = 272/594 (45%), Positives = 368/594 (61%), Gaps = 15/594 (2%)

Query: 1358 REPG-FHFESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVN 1416
            REP    +++   HP I +AD+ +H  ++K  +     +EYES   GQ   W+ +  + N
Sbjct: 877  REPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDEN 936

Query: 1417 KPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFW 1476
            + KNRY N+IAYDHSRV LQ IEG   SDYIN NY+DGY   N YIATQGP+ ET  DFW
Sbjct: 937  RMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFW 996

Query: 1477 RMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSL 1536
            RMVW + +A+I+M+T L E  R+KC +YWP+  TE Y  I+VTL++T  LA + +RTF++
Sbjct: 997  RMVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAV 1055

Query: 1537 HKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRT 1596
             K G  E RE+RQF FT WPDHGVP + T  L F+R+VK+ +PP AGP+VVHCSAG GRT
Sbjct: 1056 EKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRT 1115

Query: 1597 GCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1656
            GCFIVID ML+  + E  VD+Y  V  +RS+R  MVQTE+QY FIH+A+LEA  CG+T V
Sbjct: 1116 GCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSV 1175

Query: 1657 PARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFIS---ANLPCNKFKNRLVN 1713
            PA  + +    + +++P  + + ++ EF+ L N    T R      A LP N  KNR ++
Sbjct: 1176 PASQVRSLYYDMNKLDPQTNSSQIKEEFRTL-NMVTPTLRVEDCSIALLPRNHEKNRCMD 1234

Query: 1714 IMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNS 1773
            I+P +     L  I G E S+YINA+ +D Y+Q  A+I TQ PL  T +DFWR++ + + 
Sbjct: 1235 ILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHC 1293

Query: 1774 TIVVMLTKLREMGREKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARD 1830
            T VVML  +     + C QYWP     R    Q   V    E ++   I R +     +D
Sbjct: 1294 TSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQD 1351

Query: 1831 GQSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTG 1888
            G  R V+QFQF  WP  +  P S   F+  I QV K +E++ G +G   VHC  G GR+G
Sbjct: 1352 GY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSG 1410

Query: 1889 VFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1942
             F  +SIV E +R++  VD+F  VK LR  +P MV   D+Y+FCY+ ALEYL S
Sbjct: 1411 TFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464



 Score =  133 bits (334), Expect = 2e-30
 Identities = 83/243 (34%), Positives = 120/243 (49%), Gaps = 9/243 (3%)

Query: 1416 NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDF 1475
            N  KNR  +++  D     L  I+G   S+YINA  +D Y+  +A+I TQ PLP T  DF
Sbjct: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284

Query: 1476 WRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFS 1535
            WR+V +    ++VM+  ++      C QYWP  G   +G IQV  +          R F 
Sbjct: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342

Query: 1536 LHKNGSSEK--REVRQFQFTAWPDH-GVPEYPTPFLAFLRRVKTCNPP---DAGPIVVHC 1589
            ++     +   R V+QFQF  WP +   P     FL  +R+V           G  VVHC
Sbjct: 1343 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1402

Query: 1590 SAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1649
              G GR+G F  I  + E ++ ++TVDV+  V  +R+ +  MV   DQY F +E  LE +
Sbjct: 1403 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1462

Query: 1650 GCG 1652
              G
Sbjct: 1463 NSG 1465



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 100/408 (24%), Positives = 172/408 (42%), Gaps = 44/408 (10%)

Query: 255 EIMPGGNVNITCVAVGSPMPYVK-WMQGAE---------DLTPEDDMPVGRNVLELTDVK 304
           E+  G      C A+G  +   + W+QG +          +T         NV+  T  +
Sbjct: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK-R 253

Query: 305 DSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPD---PV 360
           D+  Y C+  +  GV I   A++ VK  P     P +    AT + I  ++ + +   P+
Sbjct: 254 DAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPI 313

Query: 361 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVV 418
               +EY + S  G +  ++ + +T Y IG L P++EYEI V  +     G G P  ++ 
Sbjct: 314 VAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALR 371

Query: 419 TRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKH 478
           TRT    P   PR ++   + +  + ++W EP   N + R +    T+   + VG  ++ 
Sbjct: 372 TRTKCADPMRGPRKLEVVEVKSRQITIRW-EPFGYN-VTRCHSYNLTVHYCYQVGGQEQV 429

Query: 479 NVDDSLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMN 530
             + S  T       T+ +L      +V+++     G    S  + V+T + +PG  P  
Sbjct: 430 REEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTE 488

Query: 531 LRAEARSETSITLSWSPPRQE--SIIKYELLFR-------EGDHGREVGRT--FDPTTSY 579
               +  E  I L W  P Q    I  YE+ ++       E D   + GR       T +
Sbjct: 489 SIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHF 548

Query: 580 VVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ-SKPSAPPQDVK 626
           +   L P T Y+F + A + +G G   P   Q T + S PS P  +++
Sbjct: 549 LFFGLYPGTTYSFTIRASTAKGFG--PPATNQFTTKISAPSMPAYELE 594



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 63/248 (25%), Positives = 105/248 (42%), Gaps = 15/248 (6%)

Query: 576 TTSYVVEDLKPNTEYAFRLAARSPQ--GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRST 633
           +TSY +  L P+TEY   +    P   G G+  P +R RT  + P   P+ ++ V V+S 
Sbjct: 335 STSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSR 394

Query: 634 AILVSWRPPPPETHNGALVGYSVRY-RPLGSEDPEPKEVN-GIPPTTTQILLEALEKWTQ 691
            I + W P             +V Y   +G ++   +EV+     +  Q  +  L  +T 
Sbjct: 395 QITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTN 454

Query: 692 YRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHG 751
             +  +     G   ES  ++V+TDED+P A P +    +     I + WR P   + +G
Sbjct: 455 VSVKLILMNPEG-RKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYG 511

Query: 752 QIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTA-EYEMVITNLQPETAYSITVA 810
            I  Y++ Y  +   +        ++ L++          E   +   L P T YS T+ 
Sbjct: 512 VITLYEITYKAVSSFD-------PEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIR 564

Query: 811 AYTMKGDG 818
           A T KG G
Sbjct: 565 ASTAKGFG 572



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 78/326 (23%), Positives = 125/326 (38%), Gaps = 35/326 (10%)

Query: 675 PPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSP---VVVRTDEDVPSAPPRKVEAEA 731
           P  +T   +  L+  T+Y I+ +  T  G G   SP   +  RT    P   PRK+E   
Sbjct: 332 PVDSTSYKIGHLDPDTEYEISVLL-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVE 390

Query: 732 LNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAE 791
           + +  I + W                VHY    G    G  ++++    +  W+T+++  
Sbjct: 391 VKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVG----GQEQVRE----EVSWDTENSHP 442

Query: 792 YEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTK-----GAVLGRPTLSVQ-QTPE 845
            +  ITNL P T  +++V    M  +G +   +++V       GAV   PT S+Q  T E
Sbjct: 443 -QHTITNLSPYT--NVSVKLILMNPEGRKESQELIVQTDEDLPGAV---PTESIQGSTFE 496

Query: 846 GSLLARWEPPA---GTAEDQVLGYRLQFGREDSTPLATLEFPPS----EDRYTASGVHKG 898
             +  +W  P    G      + Y+     +    L+      S    E  +   G++ G
Sbjct: 497 EKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPG 556

Query: 899 ATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAER 958
            TY F + A +  G G  A    +     P      LE   N +  TV +      PA  
Sbjct: 557 TTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVML---KPAHS 613

Query: 959 NGAIVK-YTVAVREAGALGPARETEL 983
            GA V  Y + V E       + TE+
Sbjct: 614 RGAPVSVYQIVVEEERPRRTKKTTEI 639



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 79/341 (23%), Positives = 121/341 (35%), Gaps = 51/341 (14%)

Query: 700  TEVGPGPESSPVVVRTDEDVPSAPPRKVEAEA------LNATAIRVLWRSPAPGRQHGQI 753
            TE G G  +   +V  +  VP APP+     A      LNA +I             G I
Sbjct: 264  TEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSIN----------GDGPI 313

Query: 754  RGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYT 813
               +V Y    G+     P               D+  Y+  I +L P+T Y I+V   T
Sbjct: 314  VAREVEYCTASGSWNDRQPV--------------DSTSYK--IGHLDPDTEYEISVLL-T 356

Query: 814  MKGDGARSKPKVVV---TKGA--VLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRL 868
              G+G    P   +   TK A  + G   L V +     +  RWEP  G    +   Y L
Sbjct: 357  RPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEP-FGYNVTRCHSYNL 415

Query: 869  QF-------GREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVL 921
                     G+E      + +   S  ++T + +        +L   +  G  E    ++
Sbjct: 416  TVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIV 475

Query: 922  SIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARE- 980
               ED P   P      G+     + L+W  P   +  G I  Y +  +   +  P  + 
Sbjct: 476  QTDEDLPGAVPTE-SIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEIDL 532

Query: 981  -TELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGP 1020
              +    ++ G E      GL P T Y   +RA T +G GP
Sbjct: 533  SNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGP 573



 Score = 38.5 bits (88), Expect = 0.065
 Identities = 73/305 (23%), Positives = 111/305 (36%), Gaps = 54/305 (17%)

Query: 1050 VLLSWEFP-DNYNSPTPYKIQYNGLTL---DVD-----------GRTTKKLITHLKPHTF 1094
            + L W  P   Y   T Y+I Y  ++    ++D           G  T  L   L P T 
Sbjct: 499  IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTT 558

Query: 1095 YNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQSP 1148
            Y+F +  R S+  G     T    F      PS+       P    D  + V L    S 
Sbjct: 559  YSFTI--RASTAKGFGPPAT--NQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614

Query: 1149 -VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRP 1207
              PV  Y IV+   R  R         + +  ++ +        Q  SL +S+       
Sbjct: 615  GAPVSVYQIVVEEERPRR---------TKKTTEILKCYPVPIHFQNASLLNSQY------ 659

Query: 1208 YIAARFSV----LPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT------F 1257
            Y AA F          F  GD K Y G+ N  L P   Y ++  A  + +  T       
Sbjct: 660  YFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQV 719

Query: 1258 AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS 1317
            A    + P  +  P+P+   D    +  VI  +L  V II + + +++ K K   KRK++
Sbjct: 720  ATKGAATPKPV--PEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKET 776

Query: 1318 EPRTK 1322
               T+
Sbjct: 777  MSSTR 781


>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
            precursor [Homo sapiens]
          Length = 1441

 Score =  476 bits (1225), Expect = e-134
 Identities = 319/966 (33%), Positives = 494/966 (51%), Gaps = 98/966 (10%)

Query: 1050 VLLSWEFPDNYNSP-TPYKIQYNGL-TLDVDG-------------RTTKKLITHLKPHTF 1094
            + + W+ P+  N   T Y+I Y  + +LD                  T  L   L P T 
Sbjct: 502  IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561

Query: 1095 YNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQS- 1147
            Y+F +  + S+  G    VT   A  +    PS+       P  + D  I V L   QS 
Sbjct: 562  YSFTI--KASTAKGFGPPVTTRIATKI--SAPSMPEYDTDTPLNETDTTITVMLKPAQSR 617

Query: 1148 --PVPVQSYFIVMVPLRKSRGGQ-----FLTPLGSPEDMDLEELIQDISRLQRRSLRHSR 1200
              PV V    +    L+KSR        F  P+       L+ L    + L+  +L    
Sbjct: 618  GAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANL---- 673

Query: 1201 QLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFA-- 1258
               V +P+              GD K Y G+ N  L P   Y ++  A+ + +  T    
Sbjct: 674  --PVTQPFTV------------GDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINC 719

Query: 1259 ---ASPFSDPFQLDNPDPQPIVDGEEGLIWVI-GPVLAVVFIICIVIAILLYKN------ 1308
               A+  +     +  +P+  VD    +  VI G ++ ++ ++ +++ I   +N      
Sbjct: 720  VRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSY 779

Query: 1309 --KPDSKRKDSEP---RTKCLLNNAD-----LAPHHPKDPVEMRRINFQTPDSGLRSPLR 1358
              K   K+K+++    R    + +AD     L+     +       +      G R  L 
Sbjct: 780  YLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELS 839

Query: 1359 EPGFHFESM---------LSHP------PIPIADMAEHTERLKANDSLKLSQEYESIDPG 1403
            +P    ++          +S+P       I +AD+ +H  ++K        +EYE++  G
Sbjct: 840  QPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEG 899

Query: 1404 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIA 1463
            Q  +W+ +  + N+ KNRY N+I+YDHSRV L  ++G   SDYINANY+DGY     YIA
Sbjct: 900  QTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIA 959

Query: 1464 TQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDT 1523
            TQGP+ ET  DFWRM+W++ SA+IVM+T L E  R+KC +YWP+  TE YG I+VTL++T
Sbjct: 960  TQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIET 1018

Query: 1524 IELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG 1583
              LA + +RTF++ K G  E RE+R F FT+WPDHGVP Y T  L F+R+VK  NPP+AG
Sbjct: 1019 EPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAG 1078

Query: 1584 PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHE 1643
            PIVVHCSAG GRTGCFI ID ML+  + E  VD++  V  +R+QR  +VQTE+QY F+H+
Sbjct: 1079 PIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHD 1138

Query: 1644 ALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFISAN 1701
            A+LEA  CGNT +P     +    +++++P  + + ++ EF+ L     +          
Sbjct: 1139 AILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGL 1198

Query: 1702 LPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETT 1761
            LP N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++ TQ PL  T 
Sbjct: 1199 LPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTV 1257

Query: 1762 EDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1821
             DFWR++++ N + VVML ++     + C QYWP + S  Y    V+ ++       I R
Sbjct: 1258 ADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHR 1315

Query: 1822 EFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF-GQDGPIS 1877
             F++ +    Q   R V+  Q+  WP  +  P S    +  + ++ K +EQ+ G++G   
Sbjct: 1316 IFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTV 1375

Query: 1878 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL 1937
            VHC  G GR+G F  +  V E ++ + ++D+F  VK LR  +  MV+T ++Y+F Y+ AL
Sbjct: 1376 VHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVAL 1435

Query: 1938 EYLGSF 1943
            EYL SF
Sbjct: 1436 EYLSSF 1441



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 117/445 (26%), Positives = 185/445 (41%), Gaps = 50/445 (11%)

Query: 234 VRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK-WMQ---GAEDLTPED 289
           VR L    R AP F  L  + E+  G N    C+A G    + K W+Q   G +      
Sbjct: 182 VRVLAHPCRKAPHFLRL-QNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT 240

Query: 290 DMPVGRNVLELTDVKDSAN-----YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTEN 343
            +   R       V D+A      Y CV  S  G  +   A++ VK  P     P   E 
Sbjct: 241 RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---EL 297

Query: 344 TATSITITWDSGNPD------PVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSE 397
            A   T  W   N +      P+    +EY++ +  G +     + +  Y +  L P+ E
Sbjct: 298 LAVGATYLWIKPNANSIIGDGPIILKEVEYRTTT--GTWAETHIVDSPNYKLWHLDPDVE 355

Query: 398 YEIWV--SAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNG 455
           YEI V  +     G GPP   + TRT    P   P+NV+   + A  + +QW    EP G
Sbjct: 356 YEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFG 411

Query: 456 --LIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLED--ETYTVRVLAFTSVGDGP 511
             + R +    T++ ++ V N Q++  ++ + T+    L       T+R+    S  +G 
Sbjct: 412 YAVTRCHSYNLTVQYQY-VFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGR 470

Query: 512 L-SDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFR------ 561
           + S+ + V+T++ VPG  P+        E  I + W PP + +  I  YE+ ++      
Sbjct: 471 MESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLD 530

Query: 562 -EGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV-VRQRTLQSK 617
              D   + G+ F     T ++   L P T Y+F + A + +G G   PV  R  T  S 
Sbjct: 531 PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFG--PPVTTRIATKISA 588

Query: 618 PSAPPQDVKC-VSVRSTAILVSWRP 641
           PS P  D    ++   T I V  +P
Sbjct: 589 PSMPEYDTDTPLNETDTTITVMLKP 613



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 83/351 (23%), Positives = 124/351 (35%), Gaps = 26/351 (7%)

Query: 416 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNW 475
           S V+   E      P  +    L A      W +P   + +  G  +   +E     G W
Sbjct: 275 SGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTW 334

Query: 476 QKHNVDDSLLTTVGSLLEDETYTVRVLAFT--SVGDGPLSDPIQVKTQQGVPGQ-PMNLR 532
            + ++ DS    +  L  D  Y +RVL       G GP   P+  +T+   P   P N+ 
Sbjct: 335 AETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVE 394

Query: 533 AEARSETSITLSWSP--------PRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDL 584
                   +TL W P              ++Y+ +F +  +  E       ++ Y +  L
Sbjct: 395 IVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQY--EAEEVIQTSSHYTLRGL 452

Query: 585 KPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPP 644
           +P      RL   +P+G      +V Q T +  P A P +          I + W+PP  
Sbjct: 453 RPFMTIRLRLLLSNPEGRMESEELVVQ-TEEDVPGAVPLESIQGGPFEEKIYIQWKPPN- 510

Query: 645 ETHNGALVGYSVRYRPLGSEDPEPKEVNGIPP-----TTTQILLEALEKWTQYRITTVAH 699
           ET NG +  Y + Y+ +GS DP     +           T  L   L   T Y  T  A 
Sbjct: 511 ET-NGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKAS 569

Query: 700 TEVGPGPESSPVVVR--TDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 748
           T  G GP   PV  R  T    PS P    +           +   PA  R
Sbjct: 570 TAKGFGP---PVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSR 617



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 87/364 (23%), Positives = 129/364 (35%), Gaps = 46/364 (12%)

Query: 678  TTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAI 737
            T  +   A    ++YR   V  ++ G G  +   ++  +   P APP   E  A+ AT  
Sbjct: 251  TVSVADTAQRSVSKYRC--VIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGAT-- 303

Query: 738  RVLWRSPAPGR--QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQ----WETDDTAE 791
              LW  P        G I   +V Y    G  A       +  + D+     W  D   E
Sbjct: 304  -YLWIKPNANSIIGDGPIILKEVEYRTTTGTWA-------ETHIVDSPNYKLWHLDPDVE 355

Query: 792  YEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGA--VLGRPTLSVQQTPEGSLL 849
            YE+ +   +P              G G    P    TK A  V G   + +       L 
Sbjct: 356  YEIRVLLTRPGEG-----------GTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLT 404

Query: 850  ARWEPPAGTAEDQVLGYRLQFGRE---DSTPLATLEFPPSEDRYTASGVHKGATYVFRLA 906
             +WEP  G A  +   Y L    +   +       E   +   YT  G+    T   RL 
Sbjct: 405  LQWEP-FGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL 463

Query: 907  ARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYT 966
              +  G  E    V+   ED P   P +    G      + ++W PP   E NG I  Y 
Sbjct: 464  LSNPEGRMESEELVVQTEEDVPGAVP-LESIQGGPFEEKIYIQWKPP--NETNGVITLYE 520

Query: 967  VAVREAGALGPARE--TELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPP 1024
            +  +  G+L P+ +  ++     +   E      GL P T Y   ++A T +G   F PP
Sbjct: 521  INYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKG---FGPP 577

Query: 1025 VRYR 1028
            V  R
Sbjct: 578  VTTR 581


>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
            precursor [Homo sapiens]
          Length = 1460

 Score =  468 bits (1204), Expect = e-131
 Identities = 242/579 (41%), Positives = 358/579 (61%), Gaps = 10/579 (1%)

Query: 1371 PPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDH 1430
            P I +AD+ +H  ++K        +EYE++  GQ  +W+ +  + N+ KNRY N+I+YDH
Sbjct: 886  PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDH 945

Query: 1431 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1490
            SRV L  ++G   SDYINANY+DGY     YIATQGP+ ET  DFWRM+W++ SA+IVM+
Sbjct: 946  SRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMV 1005

Query: 1491 TRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQF 1550
            T L E  R+KC +YWP+  TE YG I+VTL++T  LA + +RTF++ K G  E RE+R F
Sbjct: 1006 TNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLF 1064

Query: 1551 QFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIK 1610
             FT+WPDHGVP Y T  L F+R+VK  NPP+AGPIVVHCSAG GRTGCFI ID ML+  +
Sbjct: 1065 HFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAE 1124

Query: 1611 PEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQ 1670
             E  VD++  V  +R+QR  +VQTE+QY F+H+A+LEA  CGNT +P     +    +++
Sbjct: 1125 NEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISR 1184

Query: 1671 VEPGEHVTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIR 1728
            ++P  + + ++ EF+ L     +          LP N  KNR ++++P +     L  + 
Sbjct: 1185 LDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVD 1244

Query: 1729 GVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGRE 1788
            G E S+YINA+ +D ++Q  A++ TQ PL  T  DFWR++++ N + VVML ++     +
Sbjct: 1245 G-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQ 1301

Query: 1789 KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE 1846
             C QYWP + S  Y    V+ ++       I R F++ +    Q   R V+  Q+  WP 
Sbjct: 1302 FCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPA 1361

Query: 1847 -QGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEG 1904
             +  P S    +  + ++ K +EQ+ G++G   VHC  G GR+G F  +  V E ++ + 
Sbjct: 1362 YRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQN 1421

Query: 1905 VVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSF 1943
            ++D+F  VK LR  +  MV+T ++Y+F Y+ ALEYL SF
Sbjct: 1422 IIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1460



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 117/445 (26%), Positives = 185/445 (41%), Gaps = 50/445 (11%)

Query: 234 VRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK-WMQ---GAEDLTPED 289
           VR L    R AP F  L  + E+  G N    C+A G    + K W+Q   G +      
Sbjct: 182 VRVLAHPCRKAPHFLRL-QNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT 240

Query: 290 DMPVGRNVLELTDVKDSAN-----YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTEN 343
            +   R       V D+A      Y CV  S  G  +   A++ VK  P     P   E 
Sbjct: 241 RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---EL 297

Query: 344 TATSITITWDSGNPD------PVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSE 397
            A   T  W   N +      P+    +EY++ +  G +     + +  Y +  L P+ E
Sbjct: 298 LAVGATYLWIKPNANSIIGDGPIILKEVEYRTTT--GTWAETHIVDSPNYKLWHLDPDVE 355

Query: 398 YEIWV--SAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNG 455
           YEI V  +     G GPP   + TRT    P   P+NV+   + A  + +QW    EP G
Sbjct: 356 YEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFG 411

Query: 456 --LIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLED--ETYTVRVLAFTSVGDGP 511
             + R +    T++ ++ V N Q++  ++ + T+    L       T+R+    S  +G 
Sbjct: 412 YAVTRCHSYNLTVQYQY-VFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGR 470

Query: 512 L-SDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFR------ 561
           + S+ + V+T++ VPG  P+        E  I + W PP + +  I  YE+ ++      
Sbjct: 471 MESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLD 530

Query: 562 -EGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV-VRQRTLQSK 617
              D   + G+ F     T ++   L P T Y+F + A + +G G   PV  R  T  S 
Sbjct: 531 PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFG--PPVTTRIATKISA 588

Query: 618 PSAPPQDVKC-VSVRSTAILVSWRP 641
           PS P  D    ++   T I V  +P
Sbjct: 589 PSMPEYDTDTPLNETDTTITVMLKP 613



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 83/351 (23%), Positives = 124/351 (35%), Gaps = 26/351 (7%)

Query: 416 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNW 475
           S V+   E      P  +    L A      W +P   + +  G  +   +E     G W
Sbjct: 275 SGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTW 334

Query: 476 QKHNVDDSLLTTVGSLLEDETYTVRVLAFT--SVGDGPLSDPIQVKTQQGVPGQ-PMNLR 532
            + ++ DS    +  L  D  Y +RVL       G GP   P+  +T+   P   P N+ 
Sbjct: 335 AETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVE 394

Query: 533 AEARSETSITLSWSP--------PRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDL 584
                   +TL W P              ++Y+ +F +  +  E       ++ Y +  L
Sbjct: 395 IVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQY--EAEEVIQTSSHYTLRGL 452

Query: 585 KPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPP 644
           +P      RL   +P+G      +V Q T +  P A P +          I + W+PP  
Sbjct: 453 RPFMTIRLRLLLSNPEGRMESEELVVQ-TEEDVPGAVPLESIQGGPFEEKIYIQWKPPN- 510

Query: 645 ETHNGALVGYSVRYRPLGSEDPEPKEVNGIPP-----TTTQILLEALEKWTQYRITTVAH 699
           ET NG +  Y + Y+ +GS DP     +           T  L   L   T Y  T  A 
Sbjct: 511 ET-NGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKAS 569

Query: 700 TEVGPGPESSPVVVR--TDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 748
           T  G GP   PV  R  T    PS P    +           +   PA  R
Sbjct: 570 TAKGFGP---PVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSR 617



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 87/364 (23%), Positives = 129/364 (35%), Gaps = 46/364 (12%)

Query: 678  TTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAI 737
            T  +   A    ++YR   V  ++ G G  +   ++  +   P APP   E  A+ AT  
Sbjct: 251  TVSVADTAQRSVSKYRC--VIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGAT-- 303

Query: 738  RVLWRSPAPGR--QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQ----WETDDTAE 791
              LW  P        G I   +V Y    G  A       +  + D+     W  D   E
Sbjct: 304  -YLWIKPNANSIIGDGPIILKEVEYRTTTGTWA-------ETHIVDSPNYKLWHLDPDVE 355

Query: 792  YEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGA--VLGRPTLSVQQTPEGSLL 849
            YE+ +   +P              G G    P    TK A  V G   + +       L 
Sbjct: 356  YEIRVLLTRPGEG-----------GTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLT 404

Query: 850  ARWEPPAGTAEDQVLGYRLQFGRE---DSTPLATLEFPPSEDRYTASGVHKGATYVFRLA 906
             +WEP  G A  +   Y L    +   +       E   +   YT  G+    T   RL 
Sbjct: 405  LQWEP-FGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL 463

Query: 907  ARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYT 966
              +  G  E    V+   ED P   P +    G      + ++W PP   E NG I  Y 
Sbjct: 464  LSNPEGRMESEELVVQTEEDVPGAVP-LESIQGGPFEEKIYIQWKPP--NETNGVITLYE 520

Query: 967  VAVREAGALGPARE--TELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPP 1024
            +  +  G+L P+ +  ++     +   E      GL P T Y   ++A T +G   F PP
Sbjct: 521  INYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKG---FGPP 577

Query: 1025 VRYR 1028
            V  R
Sbjct: 578  VTTR 581


>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
            precursor [Homo sapiens]
          Length = 1436

 Score =  460 bits (1184), Expect = e-129
 Identities = 323/982 (32%), Positives = 482/982 (49%), Gaps = 99/982 (10%)

Query: 1029 TFLRDQVSPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNGL-----TLDVD 1078
            TF  D+  P     + +    ++  + L WE P   N   T Y+I Y  +      ++V 
Sbjct: 478  TFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVP 537

Query: 1079 G--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTAWTAFNLLNGKP 1126
            G  RT  KL        ++L P T Y F +   T +G     L +  T  +A +  +   
Sbjct: 538  GPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYAD 596

Query: 1127 SVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQFLTPLGSPEDMD 1180
              +P  +++  I V L   Q    P+  Y +++       LR+  GGQ   P+    +  
Sbjct: 597  MPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAA 656

Query: 1181 LEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQYGGFDNRGLEP 1238
            L            R L H    E+         S LP    F  GD + Y GF N  LEP
Sbjct: 657  LA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQTYRGFWNPPLEP 698

Query: 1239 GHRYVLFVLAVLQ-KSEPTFAASPFSDPFQL-DNPDPQPIVDGEEGLIWVIGPV---LAV 1293
               Y+++  A    K E        +      ++  P  +    E +  ++G     LAV
Sbjct: 699  RKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAV 758

Query: 1294 VFIICIVIAILLYKNKPDSKRKDS----EPRTKCLLNNADLAPHHPKDPVEMRRINFQTP 1349
            + ++   I +++ K KP +  K +    + +T  +++  D +        E  R+     
Sbjct: 759  LILLLGAIIVIIRKGKPVNMTKATVNYRQEKTH-MMSAVDRSFTDQSTLQEDERLGLSFM 817

Query: 1350 DS-----------------------GLRSPLREPGFHFESMLSHPPIPIADMAEHTERLK 1386
            D+                         R P    G  + +   HP + +AD+ +H  ++K
Sbjct: 818  DTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMK 877

Query: 1387 ANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDY 1446
              +     QEYES   G    W+ +  +     +R   + AYD  RV L P+ G   +DY
Sbjct: 878  TAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADY 933

Query: 1447 INANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWP 1506
            INANY+DGY   N +IATQGP PE   DFWRMVW++  ++IVM+T+L E  R+KC +YWP
Sbjct: 934  INANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP 993

Query: 1507 NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTP 1566
               ++TYG I++ L+ T  LA + VRTF+L + G S + EVRQF FTAWP+HGVP + T 
Sbjct: 994  E-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATG 1052

Query: 1567 FLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRS 1626
             LAF+RRVK   PPDAGPIV+HCSAG GRTGC+IV+D ML+  + E  VD+Y  V  + S
Sbjct: 1053 LLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCS 1112

Query: 1627 QRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKR 1686
            +R  M+QTE+QY FIH+A+LEA  CG T +P     A  +++ +++P  + + +  EF+ 
Sbjct: 1113 RRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQT 1172

Query: 1687 L--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFID 1742
            L              A LP N+ KNR ++++P +    CL  +   +G  ++YINA+  D
Sbjct: 1173 LNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTD 1229

Query: 1743 GYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGRE-KCHQYWPAERSAR 1801
             Y +  A+I T  PL  TT DFWR++++   T +VML +L +      C QYWP     +
Sbjct: 1230 SYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQ 1289

Query: 1802 YQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFID 1858
            Y    V+ M+       + R F+V +    Q     VR FQF  W   +  P S + F+ 
Sbjct: 1290 YGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLH 1349

Query: 1859 FIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQ 1918
             + +V K + + G DG   VHC  G GR+G F   + VLE +R   +VD+F   K LR  
Sbjct: 1350 LLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNY 1408

Query: 1919 RPAMVQTEDEYQFCYQAALEYL 1940
            +P MV+T D+Y FCY  ALEYL
Sbjct: 1409 KPNMVETMDQYHFCYDVALEYL 1430



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)

Query: 309 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 364
           Y CV+ +  G  +   A++ VK  P     P +     T + I  ++ +     P+    
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321

Query: 365 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 422
           IEY+     GP+     ++   Y +  L P++EYEI V  +     G G P   +++RT 
Sbjct: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379

Query: 423 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 482
              P  AP+ +    + A  + +QW EP+  N + R +    ++   + +G+     + +
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437

Query: 483 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 535
            + T       T+ +LL      VR L  T+         +  +T + VP     + AE+
Sbjct: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493

Query: 536 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 580
            +    E  I L W  P++ +  I +YE+ ++  +          P          T +V
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553

Query: 581 VEDLKPNTEYAFRLAARSPQGLG 603
             +L P T Y F + AR+ +G G
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFG 576



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 62/265 (23%), Positives = 100/265 (37%), Gaps = 27/265 (10%)

Query: 578 SYVVEDLKPNTEYAFRLAARSPQ--GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAI 635
           +Y +  L P+TEY   +    P   G G   P +  RT  ++P   P+ +    +++  +
Sbjct: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400

Query: 636 LVSWRPPPPETHNGALVGYSVRYR-PLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRI 694
            + W P             S+ Y   LGS   +   +     T   +    ++    YR 
Sbjct: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQT--IRECVKTEQGVSRYTIKNLLPYRN 458

Query: 695 TTVAHTEVGPG--PESSPVVVRTDEDVPSAPPRKVEAEALNATAIR--VLWRSPAPGRQH 750
             V      P    E   V  +TDEDVPS     + AE+L  T +   +  +   P   +
Sbjct: 459 VHVRLVLTNPEGRKEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEPQEPN 514

Query: 751 GQIRGYQVHYVRMEGAEAR----GPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYS 806
           G I  Y++ Y  +E ++      GP R    +            E   V +NL P T Y 
Sbjct: 515 GLITQYEISYQSIESSDPAVNVPGPRRTISKL----------RNETYHVFSNLHPGTTYL 564

Query: 807 ITVAAYTMKGDGARSKPKVVVTKGA 831
            +V A T KG G  +  ++     A
Sbjct: 565 FSVRARTGKGFGQAALTEITTNISA 589



 Score = 39.7 bits (91), Expect = 0.029
 Identities = 55/244 (22%), Positives = 80/244 (32%), Gaps = 35/244 (14%)

Query: 798  NLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAG 857
            +L P+T Y I+V   T  GDG   +P   +        P     + P+G   A  +    
Sbjct: 346  HLDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEP----MRAPKGLAFAEIQARQL 400

Query: 858  TAEDQVLGYRLQF---------------GREDSTPLATLEFPPSEDRYTASGVHKGATYV 902
            T + + LGY +                    + T    ++      RYT   +       
Sbjct: 401  TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460

Query: 903  FRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGT-----VLLRWLPPVPAE 957
             RL   +  G  E         ED P G       A  +   T     + L+W    P E
Sbjct: 461  VRLVLTNPEGRKEGKEVTFQTDEDVPSG------IAAESLTFTPLEDMIFLKW--EEPQE 512

Query: 958  RNGAIVKYTVAVREAGALGPARETELPAAAEPGAENAL--TLQGLKPDTAYDLQVRAHTR 1015
             NG I +Y ++ +   +  PA     P        N        L P T Y   VRA T 
Sbjct: 513  PNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTG 572

Query: 1016 RGPG 1019
            +G G
Sbjct: 573  KGFG 576



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 85/412 (20%), Positives = 152/412 (36%), Gaps = 56/412 (13%)

Query: 592 FRLAARSPQGLGA--FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNG 649
           +R  +++P+G G   F  ++ +      P APPQ ++      T +++       + +  
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEP--PTPIAPPQLLRA---GPTYLII-------QLNTN 309

Query: 650 ALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKW-----TQYRITTVAHT--EV 702
           +++G      P+  ++ E +   G       + L+  + W     T+Y I+ +     + 
Sbjct: 310 SIIGDG----PIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDG 365

Query: 703 GPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVR 762
           G G    P++ RT    P   P+ +    + A  + + W     G    +   Y V    
Sbjct: 366 GTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPL--GYNVTRCHTYTVSLCY 423

Query: 763 MEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSK 822
                +     I++ +  +        + Y   I NL P     + +     +G     +
Sbjct: 424 HYTLGSSHNQTIRECVKTE-----QGVSRY--TIKNLLPYRNVHVRLVLTNPEGRKEGKE 476

Query: 823 PKVVVTKGAVLGRPTLSVQQTP-EGSLLARWEPPAGTAEDQVLGYRLQFGREDST----- 876
                 +    G    S+  TP E  +  +WE P       +  Y + +   +S+     
Sbjct: 477 VTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQ-EPNGLITQYEISYQSIESSDPAVN 535

Query: 877 ---PLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGE----EAAEVLSIPEDTPR 929
              P  T+    +E  +  S +H G TY+F + AR+  G G+    E    +S P     
Sbjct: 536 VPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYA 595

Query: 930 GHPQILEAAGNASAGTVLLRWLPPVPAERNGA-IVKYTVAVREAGALGPARE 980
             P  L  + N    TVLLR     PA+  GA I  Y V V E  A    RE
Sbjct: 596 DMPSPLGESENTI--TVLLR-----PAQGRGAPISVYQVIVEEERARRLRRE 640


>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
            [Homo sapiens]
          Length = 1445

 Score =  455 bits (1171), Expect = e-127
 Identities = 251/592 (42%), Positives = 342/592 (57%), Gaps = 28/592 (4%)

Query: 1373 IPIADMAEHTERLKANDSLKLSQEYESID---PGQQFTWEHSNLEVNKPKNRYANVIAYD 1429
            IP+    +H   L +N+    S+++E +         T EHSN   NK KNRY N++AYD
Sbjct: 828  IPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYD 887

Query: 1430 HSRVILQPIEG--IMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATI 1487
            HSRV L+P+ G     SDYINANYVDGY    AYIATQGPL  TF DFWRM+WEQ +  I
Sbjct: 888  HSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGII 947

Query: 1488 VMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKN-------- 1539
            VM+T L EK R KCDQYWP   +E YG I VTL  T   A + VR FS+           
Sbjct: 948  VMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKG 1007

Query: 1540 ---GSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRT 1596
               G   +R V Q+ +T WPD GVPEY  P L F+RR      P+ GP++VHCSAGVGRT
Sbjct: 1008 NPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRT 1067

Query: 1597 GCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1656
            G +IVID+ML++IK + TV+V G +  +R+QRNY+VQTE+QY FIH+ALLEA+    TEV
Sbjct: 1068 GTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEV 1127

Query: 1657 PARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMP 1716
             +  L++Y+  +     G   T +E +FK +    A      SA   CNK KNR  +++P
Sbjct: 1128 SSNQLHSYVNSILIPGVGGK-TRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVP 1186

Query: 1717 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIV 1776
             E  RV L P+ G++G+DYINAS+I GY +   +I TQ PL  TT+DFWRM+W++N+ I+
Sbjct: 1187 SERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQII 1246

Query: 1777 VMLTKLREMGREKCHQYWPA-ERSARYQYFVV-----DPMAEYNMPQYILREFKVTDARD 1830
            VML   + +  ++   YWP+ E S   + F V     D +   N  Q I+ +F +   +D
Sbjct: 1247 VMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQD 1305

Query: 1831 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVF 1890
                 VR FQ   WP    P S     + I  +   +E   +DGP  VH   G    G+ 
Sbjct: 1306 DYVLEVRHFQCPKWPNPDAPISST--FELINVI--KEEALTRDGPTIVHDEYGAVSAGML 1361

Query: 1891 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1942
              L+ + +++  E  VD+FQ  KM+   RP +    ++YQF Y+A L  + +
Sbjct: 1362 CALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST 1413



 Score = 34.7 bits (78), Expect = 0.94
 Identities = 18/92 (19%), Positives = 41/92 (44%), Gaps = 7/92 (7%)

Query: 512 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS-------PPRQESIIKYELLFREGD 564
           L +P+  +  +     P++++ +  ++T++ +SWS       PP    +I Y     E +
Sbjct: 334 LENPLGTEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDE 393

Query: 565 HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA 596
             +   +  D      +  + P++ Y FR+ A
Sbjct: 394 KEKTFTKDSDKDLKATISHVSPDSLYLFRVQA 425



 Score = 32.0 bits (71), Expect = 6.1
 Identities = 21/93 (22%), Positives = 40/93 (43%), Gaps = 12/93 (12%)

Query: 719 VPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVM 778
           V S+PP  ++ + LN TA++V W  P     H  I  Y + Y   +  + +         
Sbjct: 345 VCSSPPIHMKVQPLNQTALQVSWSQPET-IYHPPIMNYMISYSWTKNEDEK--------- 394

Query: 779 LADAQWETDDTAEYEMVITNLQPETAYSITVAA 811
             +  +  D   + +  I+++ P++ Y   V A
Sbjct: 395 --EKTFTKDSDKDLKATISHVSPDSLYLFRVQA 425


>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
            precursor [Homo sapiens]
          Length = 1442

 Score =  454 bits (1167), Expect = e-127
 Identities = 323/988 (32%), Positives = 482/988 (48%), Gaps = 105/988 (10%)

Query: 1029 TFLRDQVSPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNGL-----TLDVD 1078
            TF  D+  P     + +    ++  + L WE P   N   T Y+I Y  +      ++V 
Sbjct: 478  TFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVP 537

Query: 1079 G--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTAWTAFNLLNGKP 1126
            G  RT  KL        ++L P T Y F +   T +G     L +  T  +A +  +   
Sbjct: 538  GPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYAD 596

Query: 1127 SVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQFLTPLGSPEDMD 1180
              +P  +++  I V L   Q    P+  Y +++       LR+  GGQ   P+    +  
Sbjct: 597  MPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAA 656

Query: 1181 LEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQYGGFDNRGLEP 1238
            L            R L H    E+         S LP    F  GD + Y GF N  LEP
Sbjct: 657  LA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQTYRGFWNPPLEP 698

Query: 1239 GHRYVLFVLAVLQ-KSEPTFAASPFSDPFQL-DNPDPQPIVDGEEGLIWVIGPV---LAV 1293
               Y+++  A    K E        +      ++  P  +    E +  ++G     LAV
Sbjct: 699  RKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAV 758

Query: 1294 VFIICIVIAILLYKNKPDSKRKDS----EPRTKCLLNNADLAPHHPKDPVEMRRINFQTP 1349
            + ++   I +++ K KP +  K +    + +T  +++  D +        E  R+     
Sbjct: 759  LILLLGAIIVIIRKGKPVNMTKATVNYRQEKTH-MMSAVDRSFTDQSTLQEDERLGLSFM 817

Query: 1350 DS-----------------------GLRSPLREPGFHFESMLSHPPIPIADMAEHTERLK 1386
            D+                         R P    G  + +   HP + +AD+ +H  ++K
Sbjct: 818  DTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMK 877

Query: 1387 ANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDY 1446
              +     QEYES   G    W+ +  +     +R   + AYD  RV L P+ G   +DY
Sbjct: 878  TAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADY 933

Query: 1447 INANYVD------GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIK 1500
            INANY+D      GY   N +IATQGP PE   DFWRMVW++  ++IVM+T+L E  R+K
Sbjct: 934  INANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVK 993

Query: 1501 CDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV 1560
            C +YWP   ++TYG I++ L+ T  LA + VRTF+L + G S + EVRQF FTAWP+HGV
Sbjct: 994  CSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGV 1052

Query: 1561 PEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGH 1620
            P + T  LAF+RRVK   PPDAGPIV+HCSAG GRTGC+IV+D ML+  + E  VD+Y  
Sbjct: 1053 PYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNC 1112

Query: 1621 VTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGM 1680
            V  + S+R  M+QTE+QY FIH+A+LEA  CG T +P     A  +++ +++P  + + +
Sbjct: 1113 VKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQL 1172

Query: 1681 ELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDYI 1736
              EF+ L              A LP N+ KNR ++++P +    CL  +   +G  ++YI
Sbjct: 1173 REEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYI 1229

Query: 1737 NASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGRE-KCHQYWP 1795
            NA+  D Y +  A+I T  PL  TT DFWR++++   T +VML +L +      C QYWP
Sbjct: 1230 NAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWP 1289

Query: 1796 AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKS 1852
                 +Y    V+ M+       + R F+V +    Q     VR FQF  W   +  P S
Sbjct: 1290 EPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDS 1349

Query: 1853 GEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTV 1912
             + F+  + +V K + + G DG   VHC  G GR+G F   + VLE +R   +VD+F   
Sbjct: 1350 KKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAA 1408

Query: 1913 KMLRTQRPAMVQTEDEYQFCYQAALEYL 1940
            K LR  +P MV+T D+Y FCY  ALEYL
Sbjct: 1409 KTLRNYKPNMVETMDQYHFCYDVALEYL 1436



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)

Query: 309 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 364
           Y CV+ +  G  +   A++ VK  P     P +     T + I  ++ +     P+    
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321

Query: 365 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 422
           IEY+     GP+     ++   Y +  L P++EYEI V  +     G G P   +++RT 
Sbjct: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379

Query: 423 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 482
              P  AP+ +    + A  + +QW EP+  N + R +    ++   + +G+     + +
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437

Query: 483 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 535
            + T       T+ +LL      VR L  T+         +  +T + VP     + AE+
Sbjct: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493

Query: 536 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 580
            +    E  I L W  P++ +  I +YE+ ++  +          P          T +V
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553

Query: 581 VEDLKPNTEYAFRLAARSPQGLG 603
             +L P T Y F + AR+ +G G
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFG 576



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 62/265 (23%), Positives = 100/265 (37%), Gaps = 27/265 (10%)

Query: 578 SYVVEDLKPNTEYAFRLAARSPQ--GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAI 635
           +Y +  L P+TEY   +    P   G G   P +  RT  ++P   P+ +    +++  +
Sbjct: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400

Query: 636 LVSWRPPPPETHNGALVGYSVRYR-PLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRI 694
            + W P             S+ Y   LGS   +   +     T   +    ++    YR 
Sbjct: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQT--IRECVKTEQGVSRYTIKNLLPYRN 458

Query: 695 TTVAHTEVGPG--PESSPVVVRTDEDVPSAPPRKVEAEALNATAIR--VLWRSPAPGRQH 750
             V      P    E   V  +TDEDVPS     + AE+L  T +   +  +   P   +
Sbjct: 459 VHVRLVLTNPEGRKEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEPQEPN 514

Query: 751 GQIRGYQVHYVRMEGAEAR----GPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYS 806
           G I  Y++ Y  +E ++      GP R    +            E   V +NL P T Y 
Sbjct: 515 GLITQYEISYQSIESSDPAVNVPGPRRTISKL----------RNETYHVFSNLHPGTTYL 564

Query: 807 ITVAAYTMKGDGARSKPKVVVTKGA 831
            +V A T KG G  +  ++     A
Sbjct: 565 FSVRARTGKGFGQAALTEITTNISA 589



 Score = 39.7 bits (91), Expect = 0.029
 Identities = 55/244 (22%), Positives = 80/244 (32%), Gaps = 35/244 (14%)

Query: 798  NLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAG 857
            +L P+T Y I+V   T  GDG   +P   +        P     + P+G   A  +    
Sbjct: 346  HLDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEP----MRAPKGLAFAEIQARQL 400

Query: 858  TAEDQVLGYRLQF---------------GREDSTPLATLEFPPSEDRYTASGVHKGATYV 902
            T + + LGY +                    + T    ++      RYT   +       
Sbjct: 401  TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460

Query: 903  FRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGT-----VLLRWLPPVPAE 957
             RL   +  G  E         ED P G       A  +   T     + L+W    P E
Sbjct: 461  VRLVLTNPEGRKEGKEVTFQTDEDVPSG------IAAESLTFTPLEDMIFLKW--EEPQE 512

Query: 958  RNGAIVKYTVAVREAGALGPARETELPAAAEPGAENAL--TLQGLKPDTAYDLQVRAHTR 1015
             NG I +Y ++ +   +  PA     P        N        L P T Y   VRA T 
Sbjct: 513  PNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTG 572

Query: 1016 RGPG 1019
            +G G
Sbjct: 573  KGFG 576



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 85/412 (20%), Positives = 152/412 (36%), Gaps = 56/412 (13%)

Query: 592 FRLAARSPQGLGA--FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNG 649
           +R  +++P+G G   F  ++ +      P APPQ ++      T +++       + +  
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEP--PTPIAPPQLLRA---GPTYLII-------QLNTN 309

Query: 650 ALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKW-----TQYRITTVAHT--EV 702
           +++G      P+  ++ E +   G       + L+  + W     T+Y I+ +     + 
Sbjct: 310 SIIGDG----PIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDG 365

Query: 703 GPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVR 762
           G G    P++ RT    P   P+ +    + A  + + W     G    +   Y V    
Sbjct: 366 GTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPL--GYNVTRCHTYTVSLCY 423

Query: 763 MEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSK 822
                +     I++ +  +        + Y   I NL P     + +     +G     +
Sbjct: 424 HYTLGSSHNQTIRECVKTE-----QGVSRY--TIKNLLPYRNVHVRLVLTNPEGRKEGKE 476

Query: 823 PKVVVTKGAVLGRPTLSVQQTP-EGSLLARWEPPAGTAEDQVLGYRLQFGREDST----- 876
                 +    G    S+  TP E  +  +WE P       +  Y + +   +S+     
Sbjct: 477 VTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQ-EPNGLITQYEISYQSIESSDPAVN 535

Query: 877 ---PLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGE----EAAEVLSIPEDTPR 929
              P  T+    +E  +  S +H G TY+F + AR+  G G+    E    +S P     
Sbjct: 536 VPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYA 595

Query: 930 GHPQILEAAGNASAGTVLLRWLPPVPAERNGA-IVKYTVAVREAGALGPARE 980
             P  L  + N    TVLLR     PA+  GA I  Y V V E  A    RE
Sbjct: 596 DMPSPLGESENTI--TVLLR-----PAQGRGAPISVYQVIVEEERARRLRRE 640


>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
            precursor [Homo sapiens]
          Length = 1446

 Score =  453 bits (1166), Expect = e-127
 Identities = 327/992 (32%), Positives = 479/992 (48%), Gaps = 109/992 (10%)

Query: 1029 TFLRDQVSPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNGL-----TLDVD 1078
            TF  D+  P     + +    ++  + L WE P   N   T Y+I Y  +      ++V 
Sbjct: 478  TFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVP 537

Query: 1079 G--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTAWTAFNLLNGKP 1126
            G  RT  KL        ++L P T Y F +   T +G     L +  T  +A +  +   
Sbjct: 538  GPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYAD 596

Query: 1127 SVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQFLTPLGSPEDMD 1180
              +P  +++  I V L   Q    P+  Y +++       LR+  GGQ   P+    +  
Sbjct: 597  MPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAA 656

Query: 1181 LEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQYGGFDNRGLEP 1238
            L            R L H    E+         S LP    F  GD + Y GF N  LEP
Sbjct: 657  LA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQTYRGFWNPPLEP 698

Query: 1239 GHRYVL-FVLAVLQKSEPTFAASPFSDPFQL-DNPDPQPIVDGEEGLIWVIGPV---LAV 1293
               Y++ F  A   K E        +      ++  P  +    E +  ++G     LAV
Sbjct: 699  RKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAV 758

Query: 1294 VFIICIVIAILLYKNKPDSKRKDSEPR----TKCLLNNADLAPH---------------- 1333
            + ++   I +++ K + D       P+    TK  +N      H                
Sbjct: 759  LILLLGAIIVIIRKGR-DHYAYSYYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQ 817

Query: 1334 ------------HPKDPVEMRRINFQTPDSGL-----RSPLREPGFHFESMLSHPPIPIA 1376
                        H       +R    T  S L     R P    G  + +   HP + +A
Sbjct: 818  EDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVA 877

Query: 1377 DMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQ 1436
            D+ +H  ++K  +     QEYES   G    W+ +  +     +R   + AYD  RV L 
Sbjct: 878  DLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLH 933

Query: 1437 PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEK 1496
            P+ G   +DYINANY+DGY   N +IATQGP PE   DFWRMVW++  ++IVM+T+L E 
Sbjct: 934  PMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEV 993

Query: 1497 SRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWP 1556
             R+KC +YWP   ++TYG I++ L+ T  LA + VRTF+L + G S + EVRQF FTAWP
Sbjct: 994  GRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWP 1052

Query: 1557 DHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVD 1616
            +HGVP + T  LAF+RRVK   PPDAGPIV+HCSAG GRTGC+IV+D ML+  + E  VD
Sbjct: 1053 EHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVD 1112

Query: 1617 VYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEH 1676
            +Y  V  + S+R  M+QTE+QY FIH+A+LEA  CG T +P     A  +++ +++P  +
Sbjct: 1113 IYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSN 1172

Query: 1677 VTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG-- 1732
             + +  EF+ L              A LP N+ KNR ++++P +    CL  +   +G  
Sbjct: 1173 SSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDS 1229

Query: 1733 SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGRE-KCH 1791
            ++YINA+  D Y +  A+I T  PL  TT DFWR++++   T +VML +L +      C 
Sbjct: 1230 NNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCL 1289

Query: 1792 QYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QG 1848
            QYWP     +Y    V+ M+       + R F+V +    Q     VR FQF  W   + 
Sbjct: 1290 QYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRD 1349

Query: 1849 VPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDI 1908
             P S + F+  + +V K + + G DG   VHC  G GR+G F   + VLE +R   +VD+
Sbjct: 1350 TPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDV 1408

Query: 1909 FQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1940
            F   K LR  +P MV+T D+Y FCY  ALEYL
Sbjct: 1409 FFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1440



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)

Query: 309 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 364
           Y CV+ +  G  +   A++ VK  P     P +     T + I  ++ +     P+    
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321

Query: 365 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 422
           IEY+     GP+     ++   Y +  L P++EYEI V  +     G G P   +++RT 
Sbjct: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379

Query: 423 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 482
              P  AP+ +    + A  + +QW EP+  N + R +    ++   + +G+     + +
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437

Query: 483 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 535
            + T       T+ +LL      VR L  T+         +  +T + VP     + AE+
Sbjct: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493

Query: 536 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 580
            +    E  I L W  P++ +  I +YE+ ++  +          P          T +V
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553

Query: 581 VEDLKPNTEYAFRLAARSPQGLG 603
             +L P T Y F + AR+ +G G
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFG 576



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 62/265 (23%), Positives = 100/265 (37%), Gaps = 27/265 (10%)

Query: 578 SYVVEDLKPNTEYAFRLAARSPQ--GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAI 635
           +Y +  L P+TEY   +    P   G G   P +  RT  ++P   P+ +    +++  +
Sbjct: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400

Query: 636 LVSWRPPPPETHNGALVGYSVRYR-PLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRI 694
            + W P             S+ Y   LGS   +   +     T   +    ++    YR 
Sbjct: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQT--IRECVKTEQGVSRYTIKNLLPYRN 458

Query: 695 TTVAHTEVGPG--PESSPVVVRTDEDVPSAPPRKVEAEALNATAIR--VLWRSPAPGRQH 750
             V      P    E   V  +TDEDVPS     + AE+L  T +   +  +   P   +
Sbjct: 459 VHVRLVLTNPEGRKEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEPQEPN 514

Query: 751 GQIRGYQVHYVRMEGAEAR----GPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYS 806
           G I  Y++ Y  +E ++      GP R    +            E   V +NL P T Y 
Sbjct: 515 GLITQYEISYQSIESSDPAVNVPGPRRTISKL----------RNETYHVFSNLHPGTTYL 564

Query: 807 ITVAAYTMKGDGARSKPKVVVTKGA 831
            +V A T KG G  +  ++     A
Sbjct: 565 FSVRARTGKGFGQAALTEITTNISA 589



 Score = 39.7 bits (91), Expect = 0.029
 Identities = 55/244 (22%), Positives = 80/244 (32%), Gaps = 35/244 (14%)

Query: 798  NLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAG 857
            +L P+T Y I+V   T  GDG   +P   +        P     + P+G   A  +    
Sbjct: 346  HLDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEP----MRAPKGLAFAEIQARQL 400

Query: 858  TAEDQVLGYRLQF---------------GREDSTPLATLEFPPSEDRYTASGVHKGATYV 902
            T + + LGY +                    + T    ++      RYT   +       
Sbjct: 401  TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460

Query: 903  FRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGT-----VLLRWLPPVPAE 957
             RL   +  G  E         ED P G       A  +   T     + L+W    P E
Sbjct: 461  VRLVLTNPEGRKEGKEVTFQTDEDVPSG------IAAESLTFTPLEDMIFLKW--EEPQE 512

Query: 958  RNGAIVKYTVAVREAGALGPARETELPAAAEPGAENAL--TLQGLKPDTAYDLQVRAHTR 1015
             NG I +Y ++ +   +  PA     P        N        L P T Y   VRA T 
Sbjct: 513  PNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTG 572

Query: 1016 RGPG 1019
            +G G
Sbjct: 573  KGFG 576



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 85/412 (20%), Positives = 152/412 (36%), Gaps = 56/412 (13%)

Query: 592 FRLAARSPQGLGA--FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNG 649
           +R  +++P+G G   F  ++ +      P APPQ ++      T +++       + +  
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEP--PTPIAPPQLLRA---GPTYLII-------QLNTN 309

Query: 650 ALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKW-----TQYRITTVAHT--EV 702
           +++G      P+  ++ E +   G       + L+  + W     T+Y I+ +     + 
Sbjct: 310 SIIGDG----PIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDG 365

Query: 703 GPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVR 762
           G G    P++ RT    P   P+ +    + A  + + W     G    +   Y V    
Sbjct: 366 GTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPL--GYNVTRCHTYTVSLCY 423

Query: 763 MEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSK 822
                +     I++ +  +        + Y   I NL P     + +     +G     +
Sbjct: 424 HYTLGSSHNQTIRECVKTE-----QGVSRY--TIKNLLPYRNVHVRLVLTNPEGRKEGKE 476

Query: 823 PKVVVTKGAVLGRPTLSVQQTP-EGSLLARWEPPAGTAEDQVLGYRLQFGREDST----- 876
                 +    G    S+  TP E  +  +WE P       +  Y + +   +S+     
Sbjct: 477 VTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQ-EPNGLITQYEISYQSIESSDPAVN 535

Query: 877 ---PLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGE----EAAEVLSIPEDTPR 929
              P  T+    +E  +  S +H G TY+F + AR+  G G+    E    +S P     
Sbjct: 536 VPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYA 595

Query: 930 GHPQILEAAGNASAGTVLLRWLPPVPAERNGA-IVKYTVAVREAGALGPARE 980
             P  L  + N    TVLLR     PA+  GA I  Y V V E  A    RE
Sbjct: 596 DMPSPLGESENTI--TVLLR-----PAQGRGAPISVYQVIVEEERARRLRRE 640


>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
            precursor [Homo sapiens]
          Length = 2315

 Score =  412 bits (1058), Expect = e-114
 Identities = 241/592 (40%), Positives = 336/592 (56%), Gaps = 24/592 (4%)

Query: 1368 LSHPPIPIADMAEHTERLKANDSLK-LSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVI 1426
            + H P  +AD+   +   +  ++LK   QE +S       T + SN   NK KNRY N++
Sbjct: 1701 IKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIV 1760

Query: 1427 AYDHSRVILQPIEGIMG--SDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRS 1484
            AYDHSRV L  +    G  +DYINANYVDGY    AYIA QGPL  T  DFWRM+WE   
Sbjct: 1761 AYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNV 1820

Query: 1485 ATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLH----KNG 1540
              IVM+T L EK R KCDQYWP  G+E YG   VT      LA + VR F+L     K G
Sbjct: 1821 EVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKG 1880

Query: 1541 SSEKRE----VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRT 1596
            S + R     V Q+ +T WPD GVPEY  P L F+R+         GP+VVHCSAGVGRT
Sbjct: 1881 SQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRT 1940

Query: 1597 GCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1656
            G +IV+D+ML++I+ E TV+++G +  +RSQRNY+VQTE+QY FIH+ L+EA+    TEV
Sbjct: 1941 GTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV 2000

Query: 1657 PARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMP 1716
                ++AY+  L    P    T +E +F+ L+ S    S + +A   CN+ KNR  +I+P
Sbjct: 2001 LDSHIHAYVNALLIPGPAGK-TKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIP 2059

Query: 1717 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIV 1776
             E +RV +  + G EG+DYINAS+I GY Q   +I TQ PL  T +DFWRM+W++N+ +V
Sbjct: 2060 VERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV 2118

Query: 1777 VMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE-----YNMPQYILREFKVTDARD 1830
            VM+   + M  ++   YWP  +     + F V  MAE      N  + I+++F +   +D
Sbjct: 2119 VMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQD 2177

Query: 1831 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVF 1890
                 VR FQ   WP    P S     + I  +   +E   +DGP+ VH   G    G F
Sbjct: 2178 DYVLEVRHFQCPKWPNPDSPISKT--FELISVI--KEEAANRDGPMIVHDEHGGVTAGTF 2233

Query: 1891 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1942
              L+ ++ ++  E  VD++Q  KM+   RP +    ++YQF Y+  L  + +
Sbjct: 2234 CALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST 2285



 Score =  117 bits (292), Expect = 1e-25
 Identities = 79/278 (28%), Positives = 133/278 (47%), Gaps = 12/278 (4%)

Query: 1392 KLSQEYESIDPG--QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINA 1449
            KL ++++ +     QQ  +  +  + N+ KNR +++I  + SRV +  + G  G+DYINA
Sbjct: 2022 KLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINA 2080

Query: 1450 NYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG 1509
            +Y+ GY   N +I TQ PL  T  DFWRM+W+  +  +VM+   +  +  +   YWPN+ 
Sbjct: 2081 SYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKD 2139

Query: 1510 TE-TYGFIQVTLLDTIELAT-----FCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEY 1563
                    +VTL+              ++ F L         EVR FQ   WP+   P  
Sbjct: 2140 EPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPIS 2199

Query: 1564 PTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTL 1623
             T  L  + + +  N    GP++VH   G    G F  +  ++ +++ E +VDVY    +
Sbjct: 2200 KTFELISVIKEEAANRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKM 2257

Query: 1624 MRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSL 1661
            +   R  +    +QY F+++ +L  V     E P+ SL
Sbjct: 2258 INLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSL 2295



 Score = 33.1 bits (74), Expect = 2.7
 Identities = 22/84 (26%), Positives = 41/84 (48%), Gaps = 9/84 (10%)

Query: 527 QPMNLRAEARSETSITLSWSPPR---QESIIKYELLFREGDHGREVGRTFDPTTSY---- 579
           +P N++A+  + TS+ ++W  PR      I K+ +L+++ D   +    F  T  Y    
Sbjct: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEF-LTDGYQDLG 372

Query: 580 -VVEDLKPNTEYAFRLAARSPQGL 602
            ++ +L PN  Y  ++ A    GL
Sbjct: 373 AILNNLLPNMSYVLQIVAICTNGL 396


>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
            precursor [Homo sapiens]
          Length = 1256

 Score =  397 bits (1020), Expect = e-110
 Identities = 235/600 (39%), Positives = 334/600 (55%), Gaps = 33/600 (5%)

Query: 1365 ESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYA 1423
            + +++  PI    + E  +R  A++      E++SI     +F  + +    N+ KNRY 
Sbjct: 575  KQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYV 634

Query: 1424 NVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQR 1483
            +++ YD++RV L  I G  GS+YINA+Y+DG++    YIA QGP  ET  DFWRM+WEQ+
Sbjct: 635  DILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQK 694

Query: 1484 SATIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNG 1540
            +  IVM+TR EE +R KC +YWP+   GT  +G + V +        + ++  ++ +K  
Sbjct: 695  ATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKE 754

Query: 1541 SSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFI 1600
             +  REV   QFT+WPDHGVPE P   L   RRV   +   +GPIVVHCSAGVGRTG +I
Sbjct: 755  KATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYI 814

Query: 1601 VIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARS 1660
             IDAMLE ++ E  VDVYG+V  +R QR  MVQ E QY  IH+AL+E    G TEV    
Sbjct: 815  GIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSE 874

Query: 1661 LYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYEST 1720
            L+ Y+  + + +P    + +E EF+RL + ++  ++ I  N   NK KNR  N++PY+  
Sbjct: 875  LHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYN 933

Query: 1721 RVCLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETT 1761
            RV L+                        E S YINASFI  Y + +  IA QGPL ET 
Sbjct: 934  RVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETI 993

Query: 1762 EDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1821
             DFW+M+++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR
Sbjct: 994  GDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLR 1052

Query: 1822 EFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG------ 1874
             F++  ++   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G      
Sbjct: 1053 VFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKS 1112

Query: 1875 -PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1933
             P+ +HC  G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T ++YQF Y
Sbjct: 1113 TPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172



 Score =  198 bits (503), Expect = 5e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 1700 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1759
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681

Query: 1760 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1817
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 682  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741

Query: 1818 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1876
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 742  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799

Query: 1877 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1936
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E +Y   +QA 
Sbjct: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859

Query: 1937 LEY 1939
            +EY
Sbjct: 860  VEY 862



 Score =  155 bits (392), Expect = 4e-37
 Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)

Query: 1393 LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 1436
            L  E++ +   + +  +H  N E NK KNR +NVI YD++RV L+               
Sbjct: 894  LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 953

Query: 1437 ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1492
                  +    S YINA+++  Y      IA QGPL ET GDFW+M+++++   IVM+T 
Sbjct: 954  SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 1013

Query: 1493 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1552
            L+   +  C QYW   G +TYG I+V L DT + +T+ +R F L  +   + R V Q+Q+
Sbjct: 1014 LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 1072

Query: 1553 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1602
            T W    +P  P   ++ ++ VK   P            + P+++HC  G  +TG F  +
Sbjct: 1073 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1132

Query: 1603 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1656
              +LE  + E+ VD++  V  +R  R  MV T +QY F+++ +       N +V
Sbjct: 1133 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1186



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 33/133 (24%), Positives = 58/133 (43%), Gaps = 17/133 (12%)

Query: 518 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 577
           +KT  G PG+P  +   + +     ++W+PP Q S   + L + + +  ++         
Sbjct: 335 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 392

Query: 578 SYVVEDLKPNTEY-----AFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRS 632
            Y +++LKP T+Y     A+ +A     G  A      +       SAPP  V  ++V  
Sbjct: 393 KYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-------SAPPSQVWNMTVSM 445

Query: 633 T---AILVSWRPP 642
           T   ++ V  RPP
Sbjct: 446 TSDNSMHVKCRPP 458


>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
            precursor [Homo sapiens]
          Length = 1304

 Score =  397 bits (1020), Expect = e-110
 Identities = 235/600 (39%), Positives = 334/600 (55%), Gaps = 33/600 (5%)

Query: 1365 ESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYA 1423
            + +++  PI    + E  +R  A++      E++SI     +F  + +    N+ KNRY 
Sbjct: 623  KQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYV 682

Query: 1424 NVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQR 1483
            +++ YD++RV L  I G  GS+YINA+Y+DG++    YIA QGP  ET  DFWRM+WEQ+
Sbjct: 683  DILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQK 742

Query: 1484 SATIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNG 1540
            +  IVM+TR EE +R KC +YWP+   GT  +G + V +        + ++  ++ +K  
Sbjct: 743  ATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKE 802

Query: 1541 SSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFI 1600
             +  REV   QFT+WPDHGVPE P   L   RRV   +   +GPIVVHCSAGVGRTG +I
Sbjct: 803  KATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYI 862

Query: 1601 VIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARS 1660
             IDAMLE ++ E  VDVYG+V  +R QR  MVQ E QY  IH+AL+E    G TEV    
Sbjct: 863  GIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSE 922

Query: 1661 LYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYEST 1720
            L+ Y+  + + +P    + +E EF+RL + ++  ++ I  N   NK KNR  N++PY+  
Sbjct: 923  LHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYN 981

Query: 1721 RVCLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETT 1761
            RV L+                        E S YINASFI  Y + +  IA QGPL ET 
Sbjct: 982  RVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETI 1041

Query: 1762 EDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1821
             DFW+M+++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR
Sbjct: 1042 GDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLR 1100

Query: 1822 EFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG------ 1874
             F++  ++   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G      
Sbjct: 1101 VFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKS 1160

Query: 1875 -PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1933
             P+ +HC  G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T ++YQF Y
Sbjct: 1161 TPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1220



 Score =  198 bits (503), Expect = 5e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 1700 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1759
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 670  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 729

Query: 1760 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1817
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 730  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 789

Query: 1818 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1876
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 790  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 847

Query: 1877 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1936
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E +Y   +QA 
Sbjct: 848  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907

Query: 1937 LEY 1939
            +EY
Sbjct: 908  VEY 910



 Score =  155 bits (392), Expect = 4e-37
 Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)

Query: 1393 LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 1436
            L  E++ +   + +  +H  N E NK KNR +NVI YD++RV L+               
Sbjct: 942  LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 1001

Query: 1437 ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1492
                  +    S YINA+++  Y      IA QGPL ET GDFW+M+++++   IVM+T 
Sbjct: 1002 SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 1061

Query: 1493 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1552
            L+   +  C QYW   G +TYG I+V L DT + +T+ +R F L  +   + R V Q+Q+
Sbjct: 1062 LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 1120

Query: 1553 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1602
            T W    +P  P   ++ ++ VK   P            + P+++HC  G  +TG F  +
Sbjct: 1121 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1180

Query: 1603 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1656
              +LE  + E+ VD++  V  +R  R  MV T +QY F+++ +       N +V
Sbjct: 1181 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1234



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 33/133 (24%), Positives = 58/133 (43%), Gaps = 17/133 (12%)

Query: 518 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 577
           +KT  G PG+P  +   + +     ++W+PP Q S   + L + + +  ++         
Sbjct: 383 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 440

Query: 578 SYVVEDLKPNTEY-----AFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRS 632
            Y +++LKP T+Y     A+ +A     G  A      +       SAPP  V  ++V  
Sbjct: 441 KYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-------SAPPSQVWNMTVSM 493

Query: 633 T---AILVSWRPP 642
           T   ++ V  RPP
Sbjct: 494 TSDNSMHVKCRPP 506


>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
            precursor [Homo sapiens]
          Length = 1143

 Score =  397 bits (1020), Expect = e-110
 Identities = 235/600 (39%), Positives = 334/600 (55%), Gaps = 33/600 (5%)

Query: 1365 ESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYA 1423
            + +++  PI    + E  +R  A++      E++SI     +F  + +    N+ KNRY 
Sbjct: 462  KQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYV 521

Query: 1424 NVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQR 1483
            +++ YD++RV L  I G  GS+YINA+Y+DG++    YIA QGP  ET  DFWRM+WEQ+
Sbjct: 522  DILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQK 581

Query: 1484 SATIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNG 1540
            +  IVM+TR EE +R KC +YWP+   GT  +G + V +        + ++  ++ +K  
Sbjct: 582  ATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKE 641

Query: 1541 SSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFI 1600
             +  REV   QFT+WPDHGVPE P   L   RRV   +   +GPIVVHCSAGVGRTG +I
Sbjct: 642  KATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYI 701

Query: 1601 VIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARS 1660
             IDAMLE ++ E  VDVYG+V  +R QR  MVQ E QY  IH+AL+E    G TEV    
Sbjct: 702  GIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSE 761

Query: 1661 LYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYEST 1720
            L+ Y+  + + +P    + +E EF+RL + ++  ++ I  N   NK KNR  N++PY+  
Sbjct: 762  LHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYN 820

Query: 1721 RVCLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETT 1761
            RV L+                        E S YINASFI  Y + +  IA QGPL ET 
Sbjct: 821  RVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETI 880

Query: 1762 EDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1821
             DFW+M+++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR
Sbjct: 881  GDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLR 939

Query: 1822 EFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG------ 1874
             F++  ++   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G      
Sbjct: 940  VFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKS 999

Query: 1875 -PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1933
             P+ +HC  G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T ++YQF Y
Sbjct: 1000 TPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059



 Score =  198 bits (503), Expect = 5e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 1700 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1759
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 509  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568

Query: 1760 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1817
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 569  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628

Query: 1818 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1876
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 629  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686

Query: 1877 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1936
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E +Y   +QA 
Sbjct: 687  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746

Query: 1937 LEY 1939
            +EY
Sbjct: 747  VEY 749



 Score =  155 bits (392), Expect = 4e-37
 Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)

Query: 1393 LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 1436
            L  E++ +   + +  +H  N E NK KNR +NVI YD++RV L+               
Sbjct: 781  LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 840

Query: 1437 ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1492
                  +    S YINA+++  Y      IA QGPL ET GDFW+M+++++   IVM+T 
Sbjct: 841  SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 900

Query: 1493 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1552
            L+   +  C QYW   G +TYG I+V L DT + +T+ +R F L  +   + R V Q+Q+
Sbjct: 901  LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 959

Query: 1553 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1602
            T W    +P  P   ++ ++ VK   P            + P+++HC  G  +TG F  +
Sbjct: 960  TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1019

Query: 1603 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1656
              +LE  + E+ VD++  V  +R  R  MV T +QY F+++ +       N +V
Sbjct: 1020 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1073



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 33/133 (24%), Positives = 58/133 (43%), Gaps = 17/133 (12%)

Query: 518 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 577
           +KT  G PG+P  +   + +     ++W+PP Q S   + L + + +  ++         
Sbjct: 222 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 279

Query: 578 SYVVEDLKPNTEY-----AFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRS 632
            Y +++LKP T+Y     A+ +A     G  A      +       SAPP  V  ++V  
Sbjct: 280 KYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-------SAPPSQVWNMTVSM 332

Query: 633 T---AILVSWRPP 642
           T   ++ V  RPP
Sbjct: 333 TSDNSMHVKCRPP 345


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,041,121
Number of Sequences: 37866
Number of extensions: 4295867
Number of successful extensions: 22230
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 322
Number of HSP's successfully gapped in prelim test: 219
Number of HSP's that attempted gapping in prelim test: 10063
Number of HSP's gapped (non-prelim): 4141
length of query: 1948
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1831
effective length of database: 13,817,196
effective search space: 25299285876
effective search space used: 25299285876
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.