Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 104487002
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|104487002 protein tyrosine phosphatase, receptor type, D
isoform 5 precursor [Homo sapiens]
(1502 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 3040 0.0
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 3020 0.0
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 2352 0.0
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 2338 0.0
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 1891 0.0
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 1888 0.0
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 1888 0.0
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 1519 0.0
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 1504 0.0
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 1445 0.0
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 1444 0.0
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 598 e-171
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 598 e-171
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 598 e-170
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor... 558 e-158
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo... 550 e-156
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 513 e-145
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 510 e-144
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 507 e-143
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 501 e-141
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 501 e-141
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 498 e-140
gi|110735404 protein tyrosine phosphatase, receptor type, U isof... 469 e-132
gi|110735406 protein tyrosine phosphatase, receptor type, U isof... 463 e-130
gi|110735402 protein tyrosine phosphatase, receptor type, U isof... 462 e-129
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 458 e-128
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 424 e-118
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 396 e-110
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 396 e-110
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 396 e-110
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 3040 bits (7881), Expect = 0.0
Identities = 1502/1502 (100%), Positives = 1502/1502 (100%)
Query: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
Query: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
Query: 181 GGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPT 240
GGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPT
Sbjct: 181 GGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPT 240
Query: 241 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCV 300
NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCV
Sbjct: 241 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCV 300
Query: 301 AMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNS 360
AMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNS
Sbjct: 301 AMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNS 360
Query: 361 EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 420
EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD
Sbjct: 361 EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 420
Query: 421 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 480
VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV
Sbjct: 421 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 480
Query: 481 PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDT 540
PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDT
Sbjct: 481 PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDT 540
Query: 541 IANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISAR 600
IANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISAR
Sbjct: 541 IANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISAR 600
Query: 601 TMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVN 660
TMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVN
Sbjct: 601 TMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVN 660
Query: 661 LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPAN 720
LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPAN
Sbjct: 661 LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPAN 720
Query: 721 ENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAA 780
ENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAA
Sbjct: 721 ENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAA 780
Query: 781 HFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMD 840
HFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMD
Sbjct: 781 HFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMD 840
Query: 841 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEI 900
LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEI
Sbjct: 841 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEI 900
Query: 901 PSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQF 960
PSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQF
Sbjct: 901 PSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQF 960
Query: 961 TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQG 1020
TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQG
Sbjct: 961 TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQG 1020
Query: 1021 SLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVEL 1080
SLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVEL
Sbjct: 1021 SLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVEL 1080
Query: 1081 ATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMV 1140
ATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMV
Sbjct: 1081 ATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMV 1140
Query: 1141 VHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1200
VHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL
Sbjct: 1141 VHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1200
Query: 1201 EAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNK 1260
EAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNK
Sbjct: 1201 EAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNK 1260
Query: 1261 FKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWR 1320
FKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWR
Sbjct: 1261 FKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWR 1320
Query: 1321 MLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT 1380
MLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT
Sbjct: 1321 MLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT 1380
Query: 1381 DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGR 1440
DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGR
Sbjct: 1381 DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGR 1440
Query: 1441 TGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHY 1500
TGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHY
Sbjct: 1441 TGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHY 1500
Query: 1501 AT 1502
AT
Sbjct: 1501 AT 1502
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 3020 bits (7830), Expect = 0.0
Identities = 1498/1505 (99%), Positives = 1498/1505 (99%), Gaps = 7/1505 (0%)
Query: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
Query: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
Query: 181 ---GGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 237
GGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI
Sbjct: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
Query: 238 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 297
PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
Query: 298 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 357
TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
Query: 358 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 417
KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
Query: 418 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 477
PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
Query: 478 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 537
NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
Query: 538 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 597
SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
Query: 598 SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKL 657
SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKL
Sbjct: 601 SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKL 660
Query: 658 IVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEV 717
IVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEV
Sbjct: 661 IVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEV 720
Query: 718 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPY 777
PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPY
Sbjct: 721 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPY 780
Query: 778 IAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVV 837
IAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVV
Sbjct: 781 IAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVV 840
Query: 838 SMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNN 897
SMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYK RKRAESDSRKSSIPNN
Sbjct: 841 SMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYK----RKRAESDSRKSSIPNN 896
Query: 898 KEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPG 957
KEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPG
Sbjct: 897 KEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPG 956
Query: 958 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIA 1017
QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIA
Sbjct: 957 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIA 1016
Query: 1018 TQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDT 1077
TQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDT
Sbjct: 1017 TQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDT 1076
Query: 1078 VELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAG 1137
VELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAG
Sbjct: 1077 VELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAG 1136
Query: 1138 PMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHD 1197
PMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHD
Sbjct: 1137 PMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHD 1196
Query: 1198 ALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLP 1257
ALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLP
Sbjct: 1197 ALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLP 1256
Query: 1258 CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1317
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED
Sbjct: 1257 CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1316
Query: 1318 FWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1377
FWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF
Sbjct: 1317 FWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1376
Query: 1378 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAG 1437
KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAG
Sbjct: 1377 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAG 1436
Query: 1438 VGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF 1497
VGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF
Sbjct: 1437 VGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF 1496
Query: 1498 DHYAT 1502
DHYAT
Sbjct: 1497 DHYAT 1501
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 2352 bits (6094), Expect = 0.0
Identities = 1142/1486 (76%), Positives = 1304/1486 (87%), Gaps = 12/1486 (0%)
Query: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
Query: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSEESDQ 199
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRSG ALQIE SEE+DQ
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSG------ALQIESSEETDQ 202
Query: 200 GKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGS 259
GKYECVATNSAG RYS+PANLYVRELREVRRV PRFSI P +HEIMPGG+VNITCVAVGS
Sbjct: 203 GKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGS 262
Query: 260 PMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKAL 319
PMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITVK+L
Sbjct: 263 PMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSL 322
Query: 320 PKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAG 379
PK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS+ G
Sbjct: 323 PKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGG 382
Query: 380 LSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPE 439
LSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+EP
Sbjct: 383 LSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV 442
Query: 440 EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGP 499
EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+GDGP
Sbjct: 443 EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 502
Query: 500 LSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRI 559
LS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 503 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGR 562
Query: 560 TIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTS 619
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+QS+ KNF VK +MKTS
Sbjct: 563 TFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTS 622
Query: 620 VLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAG 679
VLLSWE P+NYNS P+KI Y+ + +VDGR T+KLI +LKP Y+FVLTNRG+S G
Sbjct: 623 VLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLG 680
Query: 680 GLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRG- 738
GLQ VTA TA ++L KP+ K + DG I V LP+ + ++ Y+I++VPL+KSRG
Sbjct: 681 GLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGG 740
Query: 739 KFIKPWESPDEMELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKH 796
+F+ P SP++M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP F GD K
Sbjct: 741 QFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQ 800
Query: 797 YGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWV 856
YGGF N+ L+ G YV FVLAV++ +E +A SP+SDP + DPQPI D EEGLIWV
Sbjct: 801 YGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWV 859
Query: 857 VGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNF 916
+GPVLAVVFIICIVIAILLYK+KPD KR +S+ R + NN ++ HHP DPVE+RR+NF
Sbjct: 860 IGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINF 919
Query: 917 QTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRY 976
QTPGM SHPPIPI ++A+H ERLKAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRY
Sbjct: 920 QTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRY 979
Query: 977 ANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQ 1036
ANVIAYDHSRV+L IEGI GSDY+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQ
Sbjct: 980 ANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQ 1039
Query: 1037 RSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSS 1096
RSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSS
Sbjct: 1040 RSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSS 1099
Query: 1097 EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVI 1156
EKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVI
Sbjct: 1100 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1159
Query: 1157 DAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLY 1216
DAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LY
Sbjct: 1160 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1219
Query: 1217 AYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1276
AYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRV
Sbjct: 1220 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1279
Query: 1277 CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKL 1336
CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKL
Sbjct: 1280 CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKL 1339
Query: 1337 REMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1396
REMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT
Sbjct: 1340 REMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1399
Query: 1397 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1456
DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY
Sbjct: 1400 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1459
Query: 1457 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1502
EGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1460 EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1505
Score = 95.5 bits (236), Expect = 3e-19
Identities = 113/470 (24%), Positives = 188/470 (40%), Gaps = 87/470 (18%)
Query: 16 LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75
LR PRF+ P+ + GG + C A G P P + W Q E + +
Sbjct: 228 LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 279
Query: 76 DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135
D + L +D A Y CVA +++G I ++TV + P G P
Sbjct: 280 DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 330
Query: 136 VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSE 195
V E T T+ + SGNPDP ++++ IE
Sbjct: 331 VTENTATSITITWDSGNPDP-VSYY-----------------------------VIEYKS 360
Query: 196 ESDQGKYECVATNSAGTRYS-------APANLYVRELREVRRVPPRFSIPPTNHEIMPGG 248
+S G Y+ + + TRYS + ++V + + + PP S+ E P
Sbjct: 361 KSQDGPYQ-IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPAS 419
Query: 249 SV-NITCVAVGSPMPYVKWMLGAED----------LTPEDDMPIG----RNV-----LEL 288
+ N+ + + V+W E T E + P+G NV +
Sbjct: 420 APRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTV 479
Query: 289 NDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTWDSG 343
+ + YT +A +++G I VK PG P+ + A TSITL+W
Sbjct: 480 GSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPP 539
Query: 344 NPEP-VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPS 402
E + Y ++ + + E+ + D TT Y V L P ++Y FR+ A + G G
Sbjct: 540 RQESIIKYELLFREGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLG-AF 596
Query: 403 EPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY 452
PV+ Q + Q S +P++ + +M+ T++L+ W+ P+ N Y++ Y
Sbjct: 597 TPVVRQRTLQ--SISPKNFKVKMIMKTSVLLSWEFPDNYNSPTP-YKIQY 643
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 2338 bits (6060), Expect = 0.0
Identities = 1138/1486 (76%), Positives = 1300/1486 (87%), Gaps = 16/1486 (1%)
Query: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
Query: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSEESDQ 199
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRSG ALQIE SEE+DQ
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSG------ALQIESSEETDQ 202
Query: 200 GKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGS 259
GKYECVATNSAG RYS+PANLYVR VRRV PRFSI P +HEIMPGG+VNITCVAVGS
Sbjct: 203 GKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSILPMSHEIMPGGNVNITCVAVGS 258
Query: 260 PMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKAL 319
PMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITVK+L
Sbjct: 259 PMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSL 318
Query: 320 PKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAG 379
PK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS+ G
Sbjct: 319 PKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGG 378
Query: 380 LSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPE 439
LSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+EP
Sbjct: 379 LSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV 438
Query: 440 EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGP 499
EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+GDGP
Sbjct: 439 EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 498
Query: 500 LSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRI 559
LS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 499 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGR 558
Query: 560 TIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTS 619
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+QS+ KNF VK +MKTS
Sbjct: 559 TFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTS 618
Query: 620 VLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAG 679
VLLSWE P+NYNS P+KI Y+ + +VDGR T+KLI +LKP Y+FVLTNRG+S G
Sbjct: 619 VLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLG 676
Query: 680 GLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRG- 738
GLQ VTA TA ++L KP+ K + DG I V LP+ + ++ Y+I++VPL+KSRG
Sbjct: 677 GLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGG 736
Query: 739 KFIKPWESPDEMELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKH 796
+F+ P SP++M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP F GD K
Sbjct: 737 QFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQ 796
Query: 797 YGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWV 856
YGGF N+ L+ G YV FVLAV++ +E +A SP+SDP + DPQPI D EEGLIWV
Sbjct: 797 YGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWV 855
Query: 857 VGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNF 916
+GPVLAVVFIICIVIAILLYK+KPD KR +S+ R + NN ++ HHP DPVE+RR+NF
Sbjct: 856 IGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINF 915
Query: 917 QTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRY 976
QTPGM SHPPIPI ++A+H ERLKAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRY
Sbjct: 916 QTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRY 975
Query: 977 ANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQ 1036
ANVIAYDHSRV+L IEGI GSDY+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQ
Sbjct: 976 ANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQ 1035
Query: 1037 RSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSS 1096
RSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSS
Sbjct: 1036 RSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSS 1095
Query: 1097 EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVI 1156
EKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVI
Sbjct: 1096 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1155
Query: 1157 DAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLY 1216
DAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LY
Sbjct: 1156 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1215
Query: 1217 AYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1276
AYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRV
Sbjct: 1216 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1275
Query: 1277 CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKL 1336
CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKL
Sbjct: 1276 CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKL 1335
Query: 1337 REMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1396
REMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT
Sbjct: 1336 REMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1395
Query: 1397 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1456
DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY
Sbjct: 1396 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1455
Query: 1457 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1502
EGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1456 EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1501
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 1891 bits (4898), Expect = 0.0
Identities = 966/1203 (80%), Positives = 1021/1203 (84%), Gaps = 35/1203 (2%)
Query: 322 PPGTPVVTESTATSITLTWDSGNPEP---------VSYYIIQHKPKNSEELYKEIDGVAT 372
PP V +TS+ ++W S P V Y +++ + + K++
Sbjct: 714 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
Query: 373 TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTIL 432
++GL P + Y V A G G S+P L T+ P PR V T L
Sbjct: 774 QDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLV-INHTQMNTAL 831
Query: 433 VQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAF 492
+QW P + G +QGYR+ + + + D T ++ +Y ++ A
Sbjct: 832 IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT--DIHKGASYVFRLSAR 889
Query: 493 TSIGDGPLSSDIQVITQTGVP-----GQPLNFKAEPESETSILLSWTPP----RSDTIAN 543
+G G +++ + +P G P N +E + TS+ LSW PP R+ I
Sbjct: 890 NKVGFGE-----EMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITK 944
Query: 544 YELVYKDGEHG--EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISART 601
Y L+Y+D +++ + T+ L GLKP++ Y ++ A + +G G + + RT
Sbjct: 945 YTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1004
Query: 602 M--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIV 659
+ +FAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIV
Sbjct: 1005 LPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIV 1064
Query: 660 NLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA 719
NLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA
Sbjct: 1065 NLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA 1124
Query: 720 NENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIA 779
NENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIA
Sbjct: 1125 NENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIA 1184
Query: 780 AHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSM 839
AHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSM
Sbjct: 1185 AHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSM 1244
Query: 840 DLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKE 899
DLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYK RKRAESDSRKSSIPNNKE
Sbjct: 1245 DLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYK----RKRAESDSRKSSIPNNKE 1300
Query: 900 IPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQ 959
IPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQ
Sbjct: 1301 IPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQ 1360
Query: 960 FTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQ 1019
FTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQ
Sbjct: 1361 FTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQ 1420
Query: 1020 GSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVE 1079
GSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVE
Sbjct: 1421 GSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVE 1480
Query: 1080 LATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPM 1139
LATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPM
Sbjct: 1481 LATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPM 1540
Query: 1140 VVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1199
VVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL
Sbjct: 1541 VVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1600
Query: 1200 LEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCN 1259
LEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCN
Sbjct: 1601 LEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCN 1660
Query: 1260 KFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFW 1319
KFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFW
Sbjct: 1661 KFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFW 1720
Query: 1320 RMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV 1379
RMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV
Sbjct: 1721 RMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV 1780
Query: 1380 TDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVG 1439
TDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVG
Sbjct: 1781 TDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVG 1840
Query: 1440 RTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDH 1499
RTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDH
Sbjct: 1841 RTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDH 1900
Query: 1500 YAT 1502
YAT
Sbjct: 1901 YAT 1903
Score = 1216 bits (3145), Expect = 0.0
Identities = 610/633 (96%), Positives = 617/633 (97%), Gaps = 6/633 (0%)
Query: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
Query: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
Query: 181 ---GGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 237
GGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI
Sbjct: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
Query: 238 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 297
PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
Query: 298 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 357
TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
Query: 358 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 417
KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
Query: 418 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 477
PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
Query: 478 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 537
NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
Query: 538 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 597
SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
Query: 598 SARTMQSMFA---KNFHVKAVMKTSVLLSWEIP 627
SARTMQS + ++ + TS+L+SW+ P
Sbjct: 601 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPP 633
Score = 138 bits (347), Expect = 5e-32
Identities = 124/428 (28%), Positives = 195/428 (45%), Gaps = 37/428 (8%)
Query: 297 YTCVAMSTLGVIEAIAQITVKALPKPPGTPV----VTESTATSITLTWDSGNPEPVSYYI 352
+ A S G+ + A+I+ + + P P T ++TSI ++W E + I
Sbjct: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
Query: 353 IQHKPK-----NSEELYKEIDGVA--TTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 405
++ K ++ EI G+ TT+Y + L +++Y V A ++G GP S V
Sbjct: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702
Query: 406 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKE--PEEPNGQIQGYRVYYT-MDPTQHVNN 462
L +T+E PS PR V+ ++ST++ V W+ P + +GQI+GY+V+Y M+ +
Sbjct: 703 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 762
Query: 463 WMKHNV--ADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK 520
M +V AD+Q I L P+ +YS+ V A+T+ GDG S V T VPG+P
Sbjct: 763 PMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVI 822
Query: 521 AEPESETSILLSWTPPRSDT---IANYELVYKDGEHGEEQRITI---EPGTSYRLQGLKP 574
+ T+ L+ W PP DT + Y L K G E T+ E + +
Sbjct: 823 NHTQMNTA-LIQWHPP-VDTFGPLQGYRL--KFGRKDMEPLTTLEFSEKEDHFTATDIHK 878
Query: 575 NSLYYFRLAARSPQGLGAS-TAEIS-ARTMQSMFAKNFHVKAVMKTSVLLSWEIP---EN 629
+ Y FRL+AR+ G G EIS + + F +N H + TSV LSW+ P E
Sbjct: 879 GASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAER 938
Query: 630 YNSAMPFKILYDDGK-----MVEEVDGRATQKLIVNLKPEKSYSF-VLTNRGNSAGGLQH 683
+ +LY D M + + T + LKP+ +Y V + G
Sbjct: 939 NGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSP 998
Query: 684 RVTAKTAP 691
V +T P
Sbjct: 999 SVQFRTLP 1006
Score = 97.8 bits (242), Expect = 7e-20
Identities = 138/609 (22%), Positives = 235/609 (38%), Gaps = 91/609 (14%)
Query: 143 ATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSEES-DQGK 201
A+ +C A+G+P P+I W K V SN + + G + L+I+ D+
Sbjct: 41 ASFICQATGDPRPKIVWNKKGKKV--SNQRFEVIEFDDGSGSV---LRIQPLRTPRDEAI 95
Query: 202 YECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM 261
YECVA+N+ G S L V ++ R P + P + + + C A G+P
Sbjct: 96 YECVASNNVG-EISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPD 154
Query: 262 PYVKWMLGAEDLTPEDDM-----------------PI-GRNVLELNDVRQSANYTCVAMS 303
P + W +D P D PI G +E ++ Y CVA +
Sbjct: 155 PEITWF---KDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATN 211
Query: 304 TLGV-IEAIAQITVKALPK----------PPGTPVVTESTATSITLTWDSGNPEPVSYYI 352
+ G A A + V+ L + PP + + +IT G+P P ++
Sbjct: 212 SAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCV-AVGSPMPYVKWM 270
Query: 353 IQHK---PKNSEELYKEI----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 405
+ + P++ + + + D + Y+ +S E PP PV
Sbjct: 271 LGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPV 330
Query: 406 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNNWM 464
+T+++ +T+I + W EP V Y + + N+
Sbjct: 331 VTEST-----------------ATSITLTWDSGNPEP--------VSYYIIQHKPKNSEE 365
Query: 465 KHNVADSQITT---IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNFK 520
+ D TT + L P Y +V+A +IG GP S + T P P + +
Sbjct: 366 LYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQ 425
Query: 521 AEPESETSILLSWTPPRSDT--IANYELVYK--DGEHGEE-QRITIEPGTSYRLQGLKPN 575
A S T+IL+ W P I Y + Y +H + + + L P
Sbjct: 426 ARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQ 485
Query: 576 SLYYFRLAARSPQGLGASTAEISARTMQSMFAK--NFHVKAVMKTSVLLSWEIPENYNSA 633
Y ++ A + G G +++I T + + NF + +TS+LLSW P + ++
Sbjct: 486 KTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRS-DTI 544
Query: 634 MPFKILYDDGKMVEE---VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTA 690
++++Y DG+ EE T + LKP Y F L R G TA+ +
Sbjct: 545 ANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAS---TAEIS 601
Query: 691 PDVLRTKPA 699
+++KP+
Sbjct: 602 ARTMQSKPS 610
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 1888 bits (4890), Expect = 0.0
Identities = 967/1212 (79%), Positives = 1022/1212 (84%), Gaps = 44/1212 (3%)
Query: 322 PPGTPVVTESTATSITLTWDSGNPEP---------VSYYIIQHKPKNSEELYKEI----- 367
PP V +TS+ ++W S P V Y +++ + + K++
Sbjct: 714 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
Query: 368 ----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQA 423
D ++GL P + Y V A G G S+P L T+ P PR V
Sbjct: 774 QWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLV-I 831
Query: 424 RMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQK 483
T L+QW P + G +QGYR+ + + + D T ++
Sbjct: 832 NHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT--DIHKGA 889
Query: 484 TYSVKVLAFTSIGDGPLSSDIQVITQTGVP-----GQPLNFKAEPESETSILLSWTPP-- 536
+Y ++ A +G G +++ + +P G P N +E + TS+ LSW PP
Sbjct: 890 SYVFRLSARNKVGFGE-----EMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVL 944
Query: 537 --RSDTIANYELVYKDGEHG--EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGA 592
R+ I Y L+Y+D +++ + T+ L GLKP++ Y ++ A + +G G
Sbjct: 945 AERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 1004
Query: 593 STAEISARTM--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD 650
+ + RT+ +FAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD
Sbjct: 1005 YSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD 1064
Query: 651 GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI 710
GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI
Sbjct: 1065 GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI 1124
Query: 711 TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR 770
TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR
Sbjct: 1125 TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR 1184
Query: 771 EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS 830
EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS
Sbjct: 1185 EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS 1244
Query: 831 PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSR 890
PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYK RKRAESDSR
Sbjct: 1245 PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYK----RKRAESDSR 1300
Query: 891 KSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQE 950
KSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQE
Sbjct: 1301 KSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQE 1360
Query: 951 YESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYR 1010
YESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYR
Sbjct: 1361 YESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYR 1420
Query: 1011 KQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLV 1070
KQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLV
Sbjct: 1421 KQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLV 1480
Query: 1071 QVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT 1130
QVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT
Sbjct: 1481 QVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT 1540
Query: 1131 CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTED 1190
CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTED
Sbjct: 1541 CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTED 1600
Query: 1191 QYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSR 1250
QYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSR
Sbjct: 1601 QYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSR 1660
Query: 1251 FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP 1310
FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP
Sbjct: 1661 FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP 1720
Query: 1311 LAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMP 1370
LAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMP
Sbjct: 1721 LAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMP 1780
Query: 1371 QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1430
QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI
Sbjct: 1781 QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1840
Query: 1431 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1490
SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA
Sbjct: 1841 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1900
Query: 1491 LEYLGSFDHYAT 1502
LEYLGSFDHYAT
Sbjct: 1901 LEYLGSFDHYAT 1912
Score = 1216 bits (3145), Expect = 0.0
Identities = 610/633 (96%), Positives = 617/633 (97%), Gaps = 6/633 (0%)
Query: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
Query: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
Query: 181 ---GGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 237
GGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI
Sbjct: 181 ESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSI 240
Query: 238 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 297
PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY
Sbjct: 241 PPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANY 300
Query: 298 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 357
TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP
Sbjct: 301 TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKP 360
Query: 358 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 417
KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA
Sbjct: 361 KNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSA 420
Query: 418 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 477
PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG
Sbjct: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG 480
Query: 478 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 537
NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR
Sbjct: 481 NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR 540
Query: 538 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 597
SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI
Sbjct: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
Query: 598 SARTMQSMFA---KNFHVKAVMKTSVLLSWEIP 627
SARTMQS + ++ + TS+L+SW+ P
Sbjct: 601 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPP 633
Score = 130 bits (328), Expect = 7e-30
Identities = 126/437 (28%), Positives = 197/437 (45%), Gaps = 46/437 (10%)
Query: 297 YTCVAMSTLGVIEAIAQITVKALPKPPGTPV----VTESTATSITLTWDSGNPEPVSYYI 352
+ A S G+ + A+I+ + + P P T ++TSI ++W E + I
Sbjct: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
Query: 353 IQHKPK-----NSEELYKEIDGVA--TTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 405
++ K ++ EI G+ TT+Y + L +++Y V A ++G GP S V
Sbjct: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702
Query: 406 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKE--PEEPNGQIQGYRVYYT-MDPTQHVNN 462
L +T+E PS PR V+ ++ST++ V W+ P + +GQI+GY+V+Y M+ +
Sbjct: 703 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 762
Query: 463 WMKHNV--ADSQ----ITT-----IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTG 511
M +V AD+Q TT I L P+ +YS+ V A+T+ GDG S V T
Sbjct: 763 PMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA 822
Query: 512 VPGQPLNFKAEPESETSILLSWTPPRSDT---IANYELVYKDGEHGEEQRITI---EPGT 565
VPG+P + T+ L+ W PP DT + Y L K G E T+ E
Sbjct: 823 VPGKPRLVINHTQMNTA-LIQWHPP-VDTFGPLQGYRL--KFGRKDMEPLTTLEFSEKED 878
Query: 566 SYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEIS-ARTMQSMFAKNFHVKAVMKTSVLLS 623
+ + + Y FRL+AR+ G G EIS + + F +N H + TSV LS
Sbjct: 879 HFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLS 938
Query: 624 WEIP---ENYNSAMPFKILYDDGK-----MVEEVDGRATQKLIVNLKPEKSYSF-VLTNR 674
W+ P E + +LY D M + + T + LKP+ +Y V +
Sbjct: 939 WQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHT 998
Query: 675 GNSAGGLQHRVTAKTAP 691
G V +T P
Sbjct: 999 SKGPGPYSPSVQFRTLP 1015
Score = 97.8 bits (242), Expect = 7e-20
Identities = 138/609 (22%), Positives = 235/609 (38%), Gaps = 91/609 (14%)
Query: 143 ATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSEES-DQGK 201
A+ +C A+G+P P+I W K V SN + + G + L+I+ D+
Sbjct: 41 ASFICQATGDPRPKIVWNKKGKKV--SNQRFEVIEFDDGSGSV---LRIQPLRTPRDEAI 95
Query: 202 YECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM 261
YECVA+N+ G S L V ++ R P + P + + + C A G+P
Sbjct: 96 YECVASNNVG-EISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPD 154
Query: 262 PYVKWMLGAEDLTPEDDM-----------------PI-GRNVLELNDVRQSANYTCVAMS 303
P + W +D P D PI G +E ++ Y CVA +
Sbjct: 155 PEITWF---KDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATN 211
Query: 304 TLGV-IEAIAQITVKALPK----------PPGTPVVTESTATSITLTWDSGNPEPVSYYI 352
+ G A A + V+ L + PP + + +IT G+P P ++
Sbjct: 212 SAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCV-AVGSPMPYVKWM 270
Query: 353 IQHK---PKNSEELYKEI----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 405
+ + P++ + + + D + Y+ +S E PP PV
Sbjct: 271 LGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPV 330
Query: 406 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNNWM 464
+T+++ +T+I + W EP V Y + + N+
Sbjct: 331 VTEST-----------------ATSITLTWDSGNPEP--------VSYYIIQHKPKNSEE 365
Query: 465 KHNVADSQITT---IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNFK 520
+ D TT + L P Y +V+A +IG GP S + T P P + +
Sbjct: 366 LYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQ 425
Query: 521 AEPESETSILLSWTPPRSDT--IANYELVYK--DGEHGEE-QRITIEPGTSYRLQGLKPN 575
A S T+IL+ W P I Y + Y +H + + + L P
Sbjct: 426 ARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQ 485
Query: 576 SLYYFRLAARSPQGLGASTAEISARTMQSMFAK--NFHVKAVMKTSVLLSWEIPENYNSA 633
Y ++ A + G G +++I T + + NF + +TS+LLSW P + ++
Sbjct: 486 KTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRS-DTI 544
Query: 634 MPFKILYDDGKMVEE---VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTA 690
++++Y DG+ EE T + LKP Y F L R G TA+ +
Sbjct: 545 ANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAS---TAEIS 601
Query: 691 PDVLRTKPA 699
+++KP+
Sbjct: 602 ARTMQSKPS 610
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 1888 bits (4890), Expect = 0.0
Identities = 967/1212 (79%), Positives = 1022/1212 (84%), Gaps = 44/1212 (3%)
Query: 322 PPGTPVVTESTATSITLTWDSGNPEP---------VSYYIIQHKPKNSEELYKEI----- 367
PP V +TS+ ++W S P V Y +++ + + K++
Sbjct: 701 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 760
Query: 368 ----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQA 423
D ++GL P + Y V A G G S+P L T+ P PR V
Sbjct: 761 QWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLV-I 818
Query: 424 RMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQK 483
T L+QW P + G +QGYR+ + + + D T ++
Sbjct: 819 NHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT--DIHKGA 876
Query: 484 TYSVKVLAFTSIGDGPLSSDIQVITQTGVP-----GQPLNFKAEPESETSILLSWTPP-- 536
+Y ++ A +G G +++ + +P G P N +E + TS+ LSW PP
Sbjct: 877 SYVFRLSARNKVGFGE-----EMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVL 931
Query: 537 --RSDTIANYELVYKDGEHG--EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGA 592
R+ I Y L+Y+D +++ + T+ L GLKP++ Y ++ A + +G G
Sbjct: 932 AERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 991
Query: 593 STAEISARTM--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD 650
+ + RT+ +FAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD
Sbjct: 992 YSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD 1051
Query: 651 GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI 710
GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI
Sbjct: 1052 GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMI 1111
Query: 711 TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR 770
TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR
Sbjct: 1112 TVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGR 1171
Query: 771 EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS 830
EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS
Sbjct: 1172 EVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATS 1231
Query: 831 PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSR 890
PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYK RKRAESDSR
Sbjct: 1232 PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYK----RKRAESDSR 1287
Query: 891 KSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQE 950
KSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQE
Sbjct: 1288 KSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQE 1347
Query: 951 YESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYR 1010
YESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYR
Sbjct: 1348 YESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYR 1407
Query: 1011 KQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLV 1070
KQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLV
Sbjct: 1408 KQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLV 1467
Query: 1071 QVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT 1130
QVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT
Sbjct: 1468 QVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT 1527
Query: 1131 CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTED 1190
CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTED
Sbjct: 1528 CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTED 1587
Query: 1191 QYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSR 1250
QYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSR
Sbjct: 1588 QYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSR 1647
Query: 1251 FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP 1310
FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP
Sbjct: 1648 FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP 1707
Query: 1311 LAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMP 1370
LAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMP
Sbjct: 1708 LAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMP 1767
Query: 1371 QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1430
QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI
Sbjct: 1768 QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1827
Query: 1431 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1490
SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA
Sbjct: 1828 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1887
Query: 1491 LEYLGSFDHYAT 1502
LEYLGSFDHYAT
Sbjct: 1888 LEYLGSFDHYAT 1899
Score = 1189 bits (3075), Expect = 0.0
Identities = 600/630 (95%), Positives = 607/630 (96%), Gaps = 13/630 (2%)
Query: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK
Sbjct: 1 MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
Query: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ
Sbjct: 61 GKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQ 120
Query: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS
Sbjct: 121 IPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS 180
Query: 181 GGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPT 240
G ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVR VRRVPPRFSIPPT
Sbjct: 181 G------ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVPPRFSIPPT 230
Query: 241 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCV 300
NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCV
Sbjct: 231 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCV 290
Query: 301 AMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNS 360
AMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNS
Sbjct: 291 AMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNS 350
Query: 361 EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 420
EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD
Sbjct: 351 EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 410
Query: 421 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 480
VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV
Sbjct: 411 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 470
Query: 481 PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDT 540
PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDT
Sbjct: 471 PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDT 530
Query: 541 IANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISAR 600
IANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISAR
Sbjct: 531 IANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISAR 590
Query: 601 TMQSMFA---KNFHVKAVMKTSVLLSWEIP 627
TMQS + ++ + TS+L+SW+ P
Sbjct: 591 TMQSKPSAPPQDISCTSPSSTSILVSWQPP 620
Score = 130 bits (328), Expect = 7e-30
Identities = 126/437 (28%), Positives = 197/437 (45%), Gaps = 46/437 (10%)
Query: 297 YTCVAMSTLGVIEAIAQITVKALPKPPGTPV----VTESTATSITLTWDSGNPEPVSYYI 352
+ A S G+ + A+I+ + + P P T ++TSI ++W E + I
Sbjct: 570 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 629
Query: 353 IQHKPK-----NSEELYKEIDGVA--TTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 405
++ K ++ EI G+ TT+Y + L +++Y V A ++G GP S V
Sbjct: 630 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 689
Query: 406 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKE--PEEPNGQIQGYRVYYT-MDPTQHVNN 462
L +T+E PS PR V+ ++ST++ V W+ P + +GQI+GY+V+Y M+ +
Sbjct: 690 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQ 749
Query: 463 WMKHNV--ADSQ----ITT-----IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTG 511
M +V AD+Q TT I L P+ +YS+ V A+T+ GDG S V T
Sbjct: 750 PMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA 809
Query: 512 VPGQPLNFKAEPESETSILLSWTPPRSDT---IANYELVYKDGEHGEEQRITI---EPGT 565
VPG+P + T+ L+ W PP DT + Y L K G E T+ E
Sbjct: 810 VPGKPRLVINHTQMNTA-LIQWHPP-VDTFGPLQGYRL--KFGRKDMEPLTTLEFSEKED 865
Query: 566 SYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEIS-ARTMQSMFAKNFHVKAVMKTSVLLS 623
+ + + Y FRL+AR+ G G EIS + + F +N H + TSV LS
Sbjct: 866 HFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLS 925
Query: 624 WEIP---ENYNSAMPFKILYDDGK-----MVEEVDGRATQKLIVNLKPEKSYSF-VLTNR 674
W+ P E + +LY D M + + T + LKP+ +Y V +
Sbjct: 926 WQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHT 985
Query: 675 GNSAGGLQHRVTAKTAP 691
G V +T P
Sbjct: 986 SKGPGPYSPSVQFRTLP 1002
Score = 102 bits (254), Expect = 3e-21
Identities = 135/596 (22%), Positives = 233/596 (39%), Gaps = 78/596 (13%)
Query: 143 ATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSEES-DQGK 201
A+ +C A+G+P P+I W K V SN + + G + L+I+ D+
Sbjct: 41 ASFICQATGDPRPKIVWNKKGKKV--SNQRFEVIEFDDGSGSV---LRIQPLRTPRDEAI 95
Query: 202 YECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM 261
YECVA+N+ G S L V ++ R P + P + + + C A G+P
Sbjct: 96 YECVASNNVG-EISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPD 154
Query: 262 PYVKWMLGAEDLTPED---------DMPIGRNVLELNDVRQSANYTCVAMSTLGV---IE 309
P + W +D P D + G +E ++ Y CVA ++ G
Sbjct: 155 PEITWF---KDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECVATNSAGTRYSAP 211
Query: 310 AIAQITVKALPK----PPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHK---PKNSEE 362
A + V+ +P PP + + +IT G+P P +++ + P++
Sbjct: 212 ANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCV-AVGSPMPYVKWMLGAEDLTPEDDMP 270
Query: 363 LYKEI----DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAP 418
+ + + D + Y+ +S E PP PV+T+++
Sbjct: 271 IGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTEST-------- 322
Query: 419 RDVQARMLSSTTILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT-- 475
+T+I + W EP V Y + + N+ + D TT
Sbjct: 323 ---------ATSITLTWDSGNPEP--------VSYYIIQHKPKNSEELYKEIDGVATTRY 365
Query: 476 -IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSW 533
+ L P Y +V+A +IG GP S + T P P + +A S T+IL+ W
Sbjct: 366 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 425
Query: 534 TPPRSDT--IANYELVYK--DGEHGEE-QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQ 588
P I Y + Y +H + + + L P Y ++ A +
Sbjct: 426 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 485
Query: 589 GLGASTAEISARTMQSMFAK--NFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMV 646
G G +++I T + + NF + +TS+LLSW P + ++ ++++Y DG+
Sbjct: 486 GDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRS-DTIANYELVYKDGEHG 544
Query: 647 EE---VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPA 699
EE T + LKP Y F L R G TA+ + +++KP+
Sbjct: 545 EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAS---TAEISARTMQSKPS 597
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 1519 bits (3932), Expect = 0.0
Identities = 797/1270 (62%), Positives = 950/1270 (74%), Gaps = 42/1270 (3%)
Query: 268 LGAEDLTPED--DMPIGRNVLELNDVRQSANY--TCVAMSTLGVIEAIAQITVKA---LP 320
LG+ED P++ +P + L + + Y T VA + +G + + V+ +P
Sbjct: 648 LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 707
Query: 321 KPPGTPVVTES-TATSITLTWDSGNPE---------PVSYYIIQHKPKNSEELYKEIDGV 370
P V E+ AT+I + W S P V Y ++ K++
Sbjct: 708 SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 767
Query: 371 ATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTT 430
+ L P + Y V A G G S+P + T VQ S
Sbjct: 768 DAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGS-- 825
Query: 431 ILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKV 489
+L +W+ P Q+ GYR+ + + + + ++ ++ + T G + TY ++
Sbjct: 826 LLARWEPPAGTAEDQVLGYRLQFGREDSTPLAT-LEFPPSEDRYTASG-VHKGATYVFRL 883
Query: 490 LAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESET-SILLSWTPP----RSDTIANY 544
A + G G ++++ I + G P +A + ++LL W PP R+ I Y
Sbjct: 884 AARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKY 943
Query: 545 ELVYKD-GEHGEEQRITI----EPGT--SYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 597
+ ++ G G + + EPG + LQGLKP++ Y ++ A + +G G + +
Sbjct: 944 TVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPV 1003
Query: 598 SARTM--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQ 655
RT + KNF VK +MKTSVLLSWE P+NYNS P+KI Y+ + +VDGR T+
Sbjct: 1004 RYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTK 1061
Query: 656 KLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLP 715
KLI +LKP Y+FVLTNRG+S GGLQ VTA TA ++L KP+ K + DG I V LP
Sbjct: 1062 KLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLP 1121
Query: 716 EVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR-KRRSIRYGREVE 773
+ + ++ Y+I++VPL+KSRG +F+ P SP++M+L+EL+++ISR +RRS+R+ R++E
Sbjct: 1122 DGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLE 1181
Query: 774 L-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPY 832
+ +PYIAA F VLP F GD K YGGF N+ L+ G YV FVLAV++ +E +A SP+
Sbjct: 1182 VPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FAASPF 1240
Query: 833 SDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKS 892
SDP + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK+KPD KR +S+ R
Sbjct: 1241 SDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTK 1300
Query: 893 SIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYE 952
+ NN ++ HHP DPVE+RR+NFQTPGM SHPPIPI ++A+H ERLKAND+LK SQEYE
Sbjct: 1301 CLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYE 1360
Query: 953 SIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQ 1012
SIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV+L IEGI GSDY+NANY+DGYR Q
Sbjct: 1361 SIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQ 1420
Query: 1013 NAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQV 1072
NAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QV
Sbjct: 1421 NAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQV 1480
Query: 1073 TLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCN 1132
TLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCN
Sbjct: 1481 TLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCN 1540
Query: 1133 PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1192
PPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY
Sbjct: 1541 PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQY 1600
Query: 1193 IFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFI 1252
FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFI
Sbjct: 1601 SFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFI 1660
Query: 1253 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1312
SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA
Sbjct: 1661 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1720
Query: 1313 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1372
ETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY
Sbjct: 1721 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1780
Query: 1373 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1432
ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV
Sbjct: 1781 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1840
Query: 1433 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE 1492
HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALE
Sbjct: 1841 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE 1900
Query: 1493 YLGSFDHYAT 1502
YLGSFDHYAT
Sbjct: 1901 YLGSFDHYAT 1910
Score = 884 bits (2285), Expect = 0.0
Identities = 455/738 (61%), Positives = 557/738 (75%), Gaps = 28/738 (3%)
Query: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
Query: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSEESDQ 199
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRSG ALQIE SEE+DQ
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSG------ALQIESSEETDQ 202
Query: 200 GKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGS 259
GKYECVATNSAG RYS+PANLYVR VRRV PRFSI P +HEIMPGG+VNITCVAVGS
Sbjct: 203 GKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSILPMSHEIMPGGNVNITCVAVGS 258
Query: 260 PMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKAL 319
PMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITVK+L
Sbjct: 259 PMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSL 318
Query: 320 PKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAG 379
PK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS+ G
Sbjct: 319 PKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGG 378
Query: 380 LSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPE 439
LSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+EP
Sbjct: 379 LSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV 438
Query: 440 EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGP 499
EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+GDGP
Sbjct: 439 EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 498
Query: 500 LSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRI 559
LS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 499 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGR 558
Query: 560 TIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFA---KNFHVKAVM 616
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+QS + ++ +V
Sbjct: 559 TFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVR 618
Query: 617 KTSVLLSWE--IPENYNSAM-----PFKILYDDGKMVEEVDG---RATQKLIVNLKPEKS 666
T++L+SW PE +N A+ ++ L + +EV+G TQ L+ L+
Sbjct: 619 STAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQ 678
Query: 667 YSFVLTNRGNSAGGLQHR-VTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA----NE 721
Y G + V +T DV P + L+ L PA +
Sbjct: 679 YRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHG 738
Query: 722 NIKGYYIIIVPLKKSRGK 739
I+GY + V ++ + +
Sbjct: 739 QIRGYQVHYVRMEGAEAR 756
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 1504 bits (3895), Expect = 0.0
Identities = 798/1295 (61%), Positives = 951/1295 (73%), Gaps = 67/1295 (5%)
Query: 268 LGAEDLTPED--DMPIGRNVLELNDVRQSANY--TCVAMSTLGVIEAIAQITVKA---LP 320
LG+ED P++ +P + L + + Y T VA + +G + + V+ +P
Sbjct: 661 LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 720
Query: 321 KPPGTPVVTES-TATSITLTWDSGNPE---------PVSYYIIQHKPKNSEELYKEI--- 367
P V E+ AT+I + W S P V Y ++ K++
Sbjct: 721 SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 780
Query: 368 ------DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 421
D A + L P + Y V A G G S+P + T V
Sbjct: 781 DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 840
Query: 422 QARMLSSTTILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 480
Q S +L +W+ P Q+ GYR+ + + + + ++ ++ + T G +
Sbjct: 841 QQTPEGS--LLARWEPPAGTAEDQVLGYRLQFGREDSTPLAT-LEFPPSEDRYTASG-VH 896
Query: 481 PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESET-SILLSWTPP--- 536
TY ++ A + G G ++++ I + G P +A + ++LL W PP
Sbjct: 897 KGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPA 956
Query: 537 -RSDTIANYELVYKD-GEHGEEQRITI----EPGT--SYRLQGLKPNSLYYFRLAARSPQ 588
R+ I Y + ++ G G + + EPG + LQGLKP++ Y ++ A + +
Sbjct: 957 ERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRR 1016
Query: 589 GLGASTAEISARTM--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMV 646
G G + + RT + KNF VK +MKTSVLLSWE P+NYNS P+KI Y+ +
Sbjct: 1017 GPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG--LT 1074
Query: 647 EEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL 706
+VDGR T+KLI +LKP Y+FVLTNRG+S GGLQ VTA TA ++L KP+ K +
Sbjct: 1075 LDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDA 1134
Query: 707 DGMITVQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR-KRR 764
DG I V LP+ + ++ Y+I++VPL+KSRG +F+ P SP++M+L+EL+++ISR +RR
Sbjct: 1135 DGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRR 1194
Query: 765 SIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAE 823
S+R+ R++E+ +PYIAA F VLP F GD K YGGF N+ L+ G YV FVLAV++ +E
Sbjct: 1195 SLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSE 1254
Query: 824 SKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRK 883
+A SP+SDP + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK+KPD K
Sbjct: 1255 PT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSK 1313
Query: 884 RAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTP----------------GMASHPPI 927
R +S+ R + NN ++ HHP DPVE+RR+NFQTP M SHPPI
Sbjct: 1314 RKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPI 1373
Query: 928 PILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV 987
PI ++A+H ERLKAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV
Sbjct: 1374 PIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV 1433
Query: 988 LLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKL 1047
+L IEGI GSDY+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+L
Sbjct: 1434 ILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRL 1493
Query: 1048 EERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFT 1107
EE+SR+KCDQYWP+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFT
Sbjct: 1494 EEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFT 1553
Query: 1108 AWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEK 1167
AWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EK
Sbjct: 1554 AWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEK 1613
Query: 1168 TVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIET 1227
TVD+YGHVTLMR+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E
Sbjct: 1614 TVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEP 1673
Query: 1228 GENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS 1287
GE+VTGMELEFKRLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS
Sbjct: 1674 GEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS 1733
Query: 1288 DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQY 1347
DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQY
Sbjct: 1734 DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQY 1793
Query: 1348 WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSG 1407
WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSG
Sbjct: 1794 WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSG 1853
Query: 1408 EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK 1467
EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK
Sbjct: 1854 EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK 1913
Query: 1468 MLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1502
MLRTQRPAMVQTED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1914 MLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1948
Score = 906 bits (2342), Expect = 0.0
Identities = 471/771 (61%), Positives = 578/771 (74%), Gaps = 31/771 (4%)
Query: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79
AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 29 AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
Query: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
+VLRIQPLRTPRDE +YECVA N+VGEI+V +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSG---GTPIRGALQIEQSEE 196
TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS TPIRGALQIE SEE
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEE 208
Query: 197 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 256
+DQGKYECVATNSAG RYS+PANLYVRELREVRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 209 TDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVA 268
Query: 257 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 316
VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 269 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 328
Query: 317 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 376
K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ + Y+ + + TTRYS
Sbjct: 329 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 388
Query: 377 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 436
+ GLSP S+YE V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 389 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 448
Query: 437 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 496
EP EPNG I+GYRVYYTM+P V NW KHNV DS +TT+G+L+ +TY+V+VLAFTS+G
Sbjct: 449 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 508
Query: 497 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 556
DGPLS IQV TQ GVPGQP+N +AE SETSI LSW+PPR ++I YEL++++G+HG E
Sbjct: 509 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 568
Query: 557 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFA---KNFHVK 613
T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T + RT+QS + ++
Sbjct: 569 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 628
Query: 614 AVMKTSVLLSWE--IPENYNSAM-----PFKILYDDGKMVEEVDG---RATQKLIVNLKP 663
+V T++L+SW PE +N A+ ++ L + +EV+G TQ L+ L+
Sbjct: 629 SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 688
Query: 664 EKSYSFVLTNRGNSAGGLQHR-VTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA--- 719
Y G + V +T DV P + L+ L PA
Sbjct: 689 WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 748
Query: 720 -NENIKGYYIIIVPLK--KSRG-KFIK-------PWESPDEMELDELLKEI 759
+ I+GY + V ++ ++RG IK WE+ D E + ++ +
Sbjct: 749 QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNL 799
Score = 137 bits (345), Expect = 8e-32
Identities = 181/776 (23%), Positives = 298/776 (38%), Gaps = 122/776 (15%)
Query: 16 LRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFD 75
LR PRF+ P+ + GG + C A G P P + W Q E + +
Sbjct: 237 LREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKW--------MQGAEDLTPE 288
Query: 76 DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135
D + L +D A Y CVA +++G I ++TV + P G P
Sbjct: 289 DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP-GTP--------M 339
Query: 136 VVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSE 195
V E T T+ + SGNPDP ++++ IE
Sbjct: 340 VTENTATSITITWDSGNPDP-VSYY-----------------------------VIEYKS 369
Query: 196 ESDQGKYECVATNSAGTRYS-------APANLYVRELREVRRVPPRFSIPPTNHEIMPGG 248
+S G Y+ + + TRYS + ++V + + + PP S+ E P
Sbjct: 370 KSQDGPYQ-IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPAS 428
Query: 249 SV-NITCVAVGSPMPYVKWMLGAED----------LTPEDDMPIG----RNV-----LEL 288
+ N+ + + V+W E T E + P+G NV +
Sbjct: 429 APRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTV 488
Query: 289 NDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTA---TSITLTWDSG 343
+ + YT +A +++G I VK PG P+ + A TSITL+W
Sbjct: 489 GSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPP 548
Query: 344 NPEP-VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPS 402
E + Y ++ + + E+ + D TT Y V L P ++Y FR+ A + G G +
Sbjct: 549 RQESIIKYELLFREGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFT 606
Query: 403 EPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYY----TMDP 456
V +T + PS+ P+DV+ + ST ILV W+ PE NG + GY V Y + DP
Sbjct: 607 PVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDP 666
Query: 457 TQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP-GQ 515
N + + L Y + +A T +G GP SS + V T VP
Sbjct: 667 EPKEVNGIPPTTTQILLEA---LEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAP 723
Query: 516 PLNFKAEPESETSILLSWTPP----RSDTIANYELVYKDGEHGE-------------EQR 558
P +AE + T+I + W P + I Y++ Y E E + +
Sbjct: 724 PRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQ 783
Query: 559 ITIEPGTSYR--LQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAK-NFHVKAV 615
+ Y + L+P + Y +AA + +G GA + T ++ + V+
Sbjct: 784 WETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQT 843
Query: 616 MKTSVLLSWEIPEN--YNSAMPFKILY--DDGKMVEEVDGRATQKLIVNLKPEKSYSFVL 671
+ S+L WE P + + +++ + +D + ++ ++ K ++V
Sbjct: 844 PEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVF 903
Query: 672 TNRGNSAGGLQHRV--TAKTAPDVLRTKPAFI---GKTNLDGMITVQLPEVPANEN 722
S GGL D R P + G + ++ LP VPA N
Sbjct: 904 RLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERN 959
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 1445 bits (3741), Expect = 0.0
Identities = 754/1202 (62%), Positives = 892/1202 (74%), Gaps = 35/1202 (2%)
Query: 322 PPGTPVVTESTATSITLTWDSGNPEP---------VSYYIIQHKPKNSEELYKEIDGVAT 372
PP V +T++ + W P V+Y +++ + +++
Sbjct: 711 PPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEA 770
Query: 373 TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTIL 432
+++GL+P + Y V A G G S+P + T+ P + ++ T L
Sbjct: 771 QETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMN--TAL 828
Query: 433 VQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAF 492
+QW P+E G++ GYR+ Y N D Q T+ L TY ++ A
Sbjct: 829 LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGK--DDQHFTVTGLHKGTTYIFRLAAK 886
Query: 493 TSIGDGPLSSDIQVITQTGVP-GQPLNFKAEPESETSILLSWTPP----RSDTIANYELV 547
G G + ++ T +P G P N + ++ L+W PP R+ I +Y +V
Sbjct: 887 NRAGLGE-EFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVV 945
Query: 548 YKDGEHGEE-QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTM--QS 604
++D +E Q IT + T + L GLKP++ Y ++ A + +G G + I +RTM +
Sbjct: 946 FRDINSQQELQNITTD--TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQ 1003
Query: 605 MFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPE 664
+FAKNF V A MKTSVLLSWE+P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P
Sbjct: 1004 VFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPN 1061
Query: 665 KSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIK 724
YSFVL NRG+SAGGLQH V+ +TAPD+L KP DG + +P V ++
Sbjct: 1062 TEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVR 1121
Query: 725 GYYIIIVPLKKSRGKFIKP-WESPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAH 781
+YI++VP+ + G + P W +P+E+ELDELL+ I + R R LKPY+AA
Sbjct: 1122 WFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQ 1181
Query: 782 FDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMD 840
DVLP FTLGD K+Y GF N+ L Y FVLA + E + K YA+SPYSD +V
Sbjct: 1182 LDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQV 1241
Query: 841 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEI 900
Q EE ++WV GPVLAV+ II IVIAILL+K K + D + + K+
Sbjct: 1242 TPAQQ--QEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGL---KDS 1296
Query: 901 PSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQF 960
H +DPVE+RRLN+QTPGM HPPIPI +LAD+IERLKAND LKFSQEYESIDPGQQF
Sbjct: 1297 LLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQF 1356
Query: 961 TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQG 1020
TWE+SNLEVNKPKNRYANVIAYDHSRV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG
Sbjct: 1357 TWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQG 1416
Query: 1021 SLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVEL 1080
LPET GDFWRM+WEQR+ATVVMMT+LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVEL
Sbjct: 1417 PLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVEL 1476
Query: 1081 ATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMV 1140
ATY VRTFAL+K+GSSEKRE+RQFQF AWPDHGVPE+PTP LAFLRRVK CNP DAGPMV
Sbjct: 1477 ATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMV 1536
Query: 1141 VHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1200
VHCSAGVGRTGCFIVIDAMLER+KHEKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALL
Sbjct: 1537 VHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALL 1596
Query: 1201 EAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNK 1260
EA TCG+TEVPARNLYA+IQKL Q+ GE+VT MELEFK LASSKAHTSRFISANLPCNK
Sbjct: 1597 EAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNK 1656
Query: 1261 FKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWR 1320
FKNRLVNIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWR
Sbjct: 1657 FKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWR 1716
Query: 1321 MLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT 1380
MLWEHNSTI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT
Sbjct: 1717 MLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT 1776
Query: 1381 DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGR 1440
DARDGQSRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGR
Sbjct: 1777 DARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGR 1836
Query: 1441 TGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHY 1500
TGVFITLSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTEDQYQ YRAALEYLGSFDHY
Sbjct: 1837 TGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHY 1896
Query: 1501 AT 1502
AT
Sbjct: 1897 AT 1898
Score = 805 bits (2080), Expect = 0.0
Identities = 404/623 (64%), Positives = 496/623 (79%), Gaps = 14/623 (2%)
Query: 9 LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68
L++L ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 18 LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77
Query: 69 FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128
FEVIEFDDG+GSVLRIQPLR RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 78 FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137
Query: 129 DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGA 188
DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRSG A
Sbjct: 138 DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSG------A 191
Query: 189 LQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGG 248
LQIE SEESDQGKYECVATNSAGTRYSAPANLYVR VRRV PRFSIPP++ E+MPGG
Sbjct: 192 LQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSIPPSSQEVMPGG 247
Query: 249 SVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVI 308
SVN+TCVAVG+PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+LG+I
Sbjct: 248 SVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMI 307
Query: 309 EAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEID 368
EA AQ+TVKALPKPP VVTE+TATS+TLTWDSGN EPV+YY IQ++ +E ++E+D
Sbjct: 308 EATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVD 367
Query: 369 GVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSS 428
GVATTRYS+ GLSP+S+Y FRV+AVN+IGRGPPSE V +T EQAPSS PR VQARMLS+
Sbjct: 368 GVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSA 427
Query: 429 TTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVK 488
+T+LVQW+ PEEPNG ++GYRVYYT D + N W KHN +TT+G+L+P TYS++
Sbjct: 428 STMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLR 487
Query: 489 VLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVY 548
VLAFT++GDGP S IQV TQ GVP QP +F+AE ES+T I LSW P + I YELVY
Sbjct: 488 VLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVY 547
Query: 549 KDGEHGEEQ-RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFA 607
E ++Q ++T +P +SY L+ LKP++LY F+LAARS G+G T I ART QS +
Sbjct: 548 WAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPS 607
Query: 608 ---KNFHVKAVMKTSVLLSWEIP 627
+ ++ T+V +SW P
Sbjct: 608 APPQKVMCVSMGSTTVRVSWVPP 630
Score = 147 bits (371), Expect = 8e-35
Identities = 121/425 (28%), Positives = 196/425 (46%), Gaps = 34/425 (8%)
Query: 297 YTCVAMSTLGV---IEAIAQITVKALPKPPGTPVVTEST-ATSITLTW-----DSGNPEP 347
+ A S +GV I T ++ P P V+ S +T++ ++W DS N
Sbjct: 580 FQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVI 639
Query: 348 VSYYIIQHKPKNSEELYKEIDGVAT--TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 405
Y + + +DG++ + + + GL +++Y V A ++G GP S PV
Sbjct: 640 TQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPV 699
Query: 406 LTQTSEQAPSSAPRDVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYYTM---DPTQHV 460
L +T E PS PR V+ L+ST + V WK P + +GQI+GY+V Y + +
Sbjct: 700 LVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGL 759
Query: 461 NNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK 520
+A++Q TTI L P+ TYSV V A+T+ GDG S V T VPG+P
Sbjct: 760 PIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMI 819
Query: 521 AEPESETSILLSWTPPRS--DTIANYELVYKDGEHGEEQRITI-EPGTSYRLQGLKPNSL 577
+ T+ LL W PP+ + Y L Y + I + + + GL +
Sbjct: 820 STTAMNTA-LLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTT 878
Query: 578 YYFRLAARSPQGLGASTAEISART---MQSMFAKNFHVKAVMKTSVLLSWEIP---ENYN 631
Y FRLAA++ GLG E RT + S F +N HV + ++ L+W+ P E
Sbjct: 879 YIFRLAAKNRAGLG-EEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNG 937
Query: 632 SAMPFKILYDDGKMVEEVDGRATQK--LIVNLKPEKSYSFVL---TNRGNSAGGLQHRVT 686
+ + +++ D +E+ T + LKP+ +Y + T++G +G L +
Sbjct: 938 RIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKG--SGPLSPSIQ 995
Query: 687 AKTAP 691
++T P
Sbjct: 996 SRTMP 1000
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 1444 bits (3737), Expect = 0.0
Identities = 746/1139 (65%), Positives = 872/1139 (76%), Gaps = 26/1139 (2%)
Query: 376 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 435
+++GL+P + Y V A G G S+P + T+ P + ++ T L+QW
Sbjct: 783 TISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMN--TALLQW 840
Query: 436 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 495
P+E G++ GYR+ Y N D Q T+ L TY ++ A
Sbjct: 841 HPPKELPGELLGYRLQYCRADEARPNTIDFGK--DDQHFTVTGLHKGTTYIFRLAAKNRA 898
Query: 496 GDGPLSSDIQVITQTGVP-GQPLNFKAEPESETSILLSWTPP----RSDTIANYELVYKD 550
G G + ++ T +P G P N + ++ L+W PP R+ I +Y +V++D
Sbjct: 899 GLGE-EFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD 957
Query: 551 GEHGEE-QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTM--QSMFA 607
+E Q IT + T + L GLKP++ Y ++ A + +G G + I +RTM + +FA
Sbjct: 958 INSQQELQNITTD--TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFA 1015
Query: 608 KNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSY 667
KNF V A MKTSVLLSWE+P++Y SA+PFKILY+ G+ VE VDG + +KLI +L+P Y
Sbjct: 1016 KNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYN-GQSVE-VDGHSMRKLIADLQPNTEY 1073
Query: 668 SFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYY 727
SFVL NRG+SAGGLQH V+ +TAPD+L KP DG + +P V ++ +Y
Sbjct: 1074 SFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFY 1133
Query: 728 IIIVPLKKSRGKFIKP-WESPDEMELDELLKEISRKRRSIRYGREV--ELKPYIAAHFDV 784
I++VP+ + G + P W +P+E+ELDELL+ I + R R LKPY+AA DV
Sbjct: 1134 IVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDV 1193
Query: 785 LPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVM-EHAESKMYATSPYSDPVVSMDLDP 843
LP FTLGD K+Y GF N+ L Y FVLA + E + K YA+SPYSD +V
Sbjct: 1194 LPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPA 1253
Query: 844 QPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEIPSH 903
Q EE ++WV GPVLAV+ II IVIAILL+K K + D + + K+
Sbjct: 1254 QQ--QEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGL---KDSLLA 1308
Query: 904 HPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWE 963
H +DPVE+RRLN+QTPGM HPPIPI +LAD+IERLKAND LKFSQEYESIDPGQQFTWE
Sbjct: 1309 HSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWE 1368
Query: 964 HSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP 1023
+SNLEVNKPKNRYANVIAYDHSRV+L++I+G+PGSDY+NANYIDGYRKQNAYIATQG LP
Sbjct: 1369 NSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLP 1428
Query: 1024 ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATY 1083
ET GDFWRM+WEQR+ATVVMMT+LEE+SRVKCDQYWP+RGTET GL+QVTLLDTVELATY
Sbjct: 1429 ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATY 1488
Query: 1084 CVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHC 1143
VRTFAL+K+GSSEKRE+RQFQF AWPDHGVPE+PTP LAFLRRVK CNP DAGPMVVHC
Sbjct: 1489 TVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHC 1548
Query: 1144 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1203
SAGVGRTGCFIVIDAMLER+KHEKTVDIYGHVT MR+QRNYMVQTEDQY+FIH+ALLEA
Sbjct: 1549 SAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA 1608
Query: 1204 TCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKN 1263
TCG+TEVPARNLYA+IQKL Q+ GE+VT MELEFK LASSKAHTSRFISANLPCNKFKN
Sbjct: 1609 TCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKN 1668
Query: 1264 RLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLW 1323
RLVNIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLW
Sbjct: 1669 RLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLW 1728
Query: 1324 EHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR 1383
EHNSTI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR
Sbjct: 1729 EHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR 1788
Query: 1384 DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGV 1443
DGQSRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGV
Sbjct: 1789 DGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGV 1848
Query: 1444 FITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1502
FITLSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTEDQYQ YRAALEYLGSFDHYAT
Sbjct: 1849 FITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1907
Score = 805 bits (2080), Expect = 0.0
Identities = 404/623 (64%), Positives = 496/623 (79%), Gaps = 14/623 (2%)
Query: 9 LLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQR 68
L++L ++ P F + P DQTG+SGGVASF+CQATG+P+P+I W KKGKKVS+QR
Sbjct: 18 LVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQR 77
Query: 69 FEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTI 128
FEVIEFDDG+GSVLRIQPLR RDEAIYEC A+N++GEI+ S +L+VL E+Q+P GFP+I
Sbjct: 78 FEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSI 137
Query: 129 DMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGA 188
DMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVD + +NGRIKQLRSG A
Sbjct: 138 DMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSG------A 191
Query: 189 LQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGG 248
LQIE SEESDQGKYECVATNSAGTRYSAPANLYVR VRRV PRFSIPP++ E+MPGG
Sbjct: 192 LQIESSEESDQGKYECVATNSAGTRYSAPANLYVR----VRRVAPRFSIPPSSQEVMPGG 247
Query: 249 SVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVI 308
SVN+TCVAVG+PMPYVKWM+GAE+LT ED+MP+GRNVLEL++V +SANYTCVA+S+LG+I
Sbjct: 248 SVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMI 307
Query: 309 EAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEID 368
EA AQ+TVKALPKPP VVTE+TATS+TLTWDSGN EPV+YY IQ++ +E ++E+D
Sbjct: 308 EATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVD 367
Query: 369 GVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSS 428
GVATTRYS+ GLSP+S+Y FRV+AVN+IGRGPPSE V +T EQAPSS PR VQARMLS+
Sbjct: 368 GVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSA 427
Query: 429 TTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVK 488
+T+LVQW+ PEEPNG ++GYRVYYT D + N W KHN +TT+G+L+P TYS++
Sbjct: 428 STMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLR 487
Query: 489 VLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVY 548
VLAFT++GDGP S IQV TQ GVP QP +F+AE ES+T I LSW P + I YELVY
Sbjct: 488 VLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVY 547
Query: 549 KDGEHGEEQ-RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFA 607
E ++Q ++T +P +SY L+ LKP++LY F+LAARS G+G T I ART QS +
Sbjct: 548 WAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPS 607
Query: 608 ---KNFHVKAVMKTSVLLSWEIP 627
+ ++ T+V +SW P
Sbjct: 608 APPQKVMCVSMGSTTVRVSWVPP 630
Score = 144 bits (364), Expect = 5e-34
Identities = 122/435 (28%), Positives = 193/435 (44%), Gaps = 45/435 (10%)
Query: 297 YTCVAMSTLGV---IEAIAQITVKALPKPPGTPVVTEST-ATSITLTW-----DSGNPEP 347
+ A S +GV I T ++ P P V+ S +T++ ++W DS N
Sbjct: 580 FQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVI 639
Query: 348 VSYYIIQHKPKNSEELYKEIDGVAT--TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 405
Y + + +DG++ + + + GL +++Y V A ++G GP S PV
Sbjct: 640 TQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPV 699
Query: 406 LTQTSEQAPSSAPRDVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYYT---------- 453
L +T E PS PR V+ L+ST + V WK P + +GQI+GY+V Y
Sbjct: 700 LVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGL 759
Query: 454 ---MDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQT 510
D W D + TTI L P+ TYSV V A+T+ GDG S V T
Sbjct: 760 PIIQDVMLAEAQWRPEESEDYE-TTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTG 818
Query: 511 GVPGQPLNFKAEPESETSILLSWTPPRS--DTIANYELVYKDGEHGEEQRITI-EPGTSY 567
VPG+P + T+ LL W PP+ + Y L Y + I + +
Sbjct: 819 AVPGRPTMMISTTAMNTA-LLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHF 877
Query: 568 RLQGLKPNSLYYFRLAARSPQGLGASTAEISART---MQSMFAKNFHVKAVMKTSVLLSW 624
+ GL + Y FRLAA++ GLG E RT + S F +N HV + ++ L+W
Sbjct: 878 TVTGLHKGTTYIFRLAAKNRAGLG-EEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAW 936
Query: 625 EIP---ENYNSAMPFKILYDDGKMVEEVDGRATQK--LIVNLKPEKSYSFVL---TNRGN 676
+ P E + + +++ D +E+ T + LKP+ +Y + T++G
Sbjct: 937 DPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKG- 995
Query: 677 SAGGLQHRVTAKTAP 691
+G L + ++T P
Sbjct: 996 -SGPLSPSIQSRTMP 1009
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 598 bits (1543), Expect = e-171
Identities = 307/678 (45%), Positives = 423/678 (62%), Gaps = 10/678 (1%)
Query: 829 TSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESD 888
T P+ + P+ +E I V L+ + +I +I +L K+A S
Sbjct: 118 TEPWEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSH 177
Query: 889 SRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFS 948
S + N + +P + L +PP+P+ +L + I R A+DN F
Sbjct: 178 SNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFR 233
Query: 949 QEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID 1007
+E+ ++ Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA++I+
Sbjct: 234 EEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFIN 293
Query: 1008 GYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH 1067
GY+++N +IA QG ET DFWRMIWEQ +AT+VM+T L+ER KC QYWP +G T+
Sbjct: 294 GYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTY 353
Query: 1068 GLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFLA 1123
G ++V++ D L Y VR F + + G R+ + QF FT+WPD GVP P L
Sbjct: 354 GNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLK 413
Query: 1124 FLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRN 1183
FL++VK CNP AG +VVHCSAGVGRTG F+VIDAML+ + E+ VD+YG V+ +RAQR
Sbjct: 414 FLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRC 473
Query: 1184 YMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS 1243
MVQT+ QY+FI+ ALLE G+TE+ +L ++QK+ G + G+E EFK+L S
Sbjct: 474 QMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTS 533
Query: 1244 SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKA 1303
K + + NLP N KNR++ I+PYE RV + RG E +DY+NASFIDGYRQ+ +
Sbjct: 534 IKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDS 593
Query: 1304 YIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDP 1363
YIA+QGPL T EDFWRM+WE S +VMLT+L E G+EKC QYWP++ Y V+
Sbjct: 594 YIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVEL 653
Query: 1364 MAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQ 1423
E Y +R+ VT+ R+ +SR +RQF F WPE G+P G+G I I V K ++Q
Sbjct: 654 KKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQ 713
Query: 1424 FGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQY 1483
G + PI+VHCSAG GRTG F LS VLER++ EG++D+FQTVK LR QRP MVQT +QY
Sbjct: 714 SG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQY 772
Query: 1484 QFSYRAALEYLGSFDHYA 1501
+F Y+ EY+ +F YA
Sbjct: 773 EFCYKVVQEYIDAFSDYA 790
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 598 bits (1543), Expect = e-171
Identities = 307/678 (45%), Positives = 423/678 (62%), Gaps = 10/678 (1%)
Query: 829 TSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESD 888
T P+ + P+ +E I V L+ + +I +I +L K+A S
Sbjct: 118 TEPWEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSH 177
Query: 889 SRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFS 948
S + N + +P + L +PP+P+ +L + I R A+DN F
Sbjct: 178 SNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFR 233
Query: 949 QEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID 1007
+E+ ++ Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA++I+
Sbjct: 234 EEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFIN 293
Query: 1008 GYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH 1067
GY+++N +IA QG ET DFWRMIWEQ +AT+VM+T L+ER KC QYWP +G T+
Sbjct: 294 GYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTY 353
Query: 1068 GLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFLA 1123
G ++V++ D L Y VR F + + G R+ + QF FT+WPD GVP P L
Sbjct: 354 GNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLK 413
Query: 1124 FLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRN 1183
FL++VK CNP AG +VVHCSAGVGRTG F+VIDAML+ + E+ VD+YG V+ +RAQR
Sbjct: 414 FLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRC 473
Query: 1184 YMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS 1243
MVQT+ QY+FI+ ALLE G+TE+ +L ++QK+ G + G+E EFK+L S
Sbjct: 474 QMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTS 533
Query: 1244 SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKA 1303
K + + NLP N KNR++ I+PYE RV + RG E +DY+NASFIDGYRQ+ +
Sbjct: 534 IKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDS 593
Query: 1304 YIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDP 1363
YIA+QGPL T EDFWRM+WE S +VMLT+L E G+EKC QYWP++ Y V+
Sbjct: 594 YIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVEL 653
Query: 1364 MAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQ 1423
E Y +R+ VT+ R+ +SR +RQF F WPE G+P G+G I I V K ++Q
Sbjct: 654 KKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQ 713
Query: 1424 FGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQY 1483
G + PI+VHCSAG GRTG F LS VLER++ EG++D+FQTVK LR QRP MVQT +QY
Sbjct: 714 SG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQY 772
Query: 1484 QFSYRAALEYLGSFDHYA 1501
+F Y+ EY+ +F YA
Sbjct: 773 EFCYKVVQEYIDAFSDYA 790
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 598 bits (1541), Expect = e-170
Identities = 315/685 (45%), Positives = 434/685 (63%), Gaps = 17/685 (2%)
Query: 824 SKMYATSPYSDPVVSMDLDPQPITDEEE--GLIWVVGPVLAVVFIICIVIAILLYKSKPD 881
S AT+P + P S + D + DE ++ + +L +VFII IV+ +L +K
Sbjct: 125 SSTAATTPETFPP-SGNSDSKDRRDETPIIAVMVALSSLLVIVFII-IVLYMLRFKKY-- 180
Query: 882 RKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKA 941
K+A S S + N + +P + L +PP+P+ +L + I R A
Sbjct: 181 -KQAGSHSNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMA 235
Query: 942 NDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDY 1000
+DN F +E+ ++ Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY
Sbjct: 236 DDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDY 295
Query: 1001 VNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP 1060
+NA++I+GY+++N +IA QG ET DFWRMIWEQ +AT+VM+T L+ER KC QYWP
Sbjct: 296 INASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWP 355
Query: 1061 SRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPE 1116
+G T+G ++V++ D L Y VR F + + G R+ + QF FT+WPD GVP
Sbjct: 356 DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPF 415
Query: 1117 HPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVT 1176
P L FL++VK CNP AG +VVHCSAGVGRTG F+VIDAML+ + E+ VD+YG V+
Sbjct: 416 TPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVS 475
Query: 1177 LMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMEL 1236
+RAQR MVQT+ QY+FI+ ALLE G+TE+ +L ++QK+ G + G+E
Sbjct: 476 RIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEE 535
Query: 1237 EFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFID 1296
EFK+L S K + + NLP N KNR++ I+PYE RV + RG E +DY+NASFID
Sbjct: 536 EFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFID 595
Query: 1297 GYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARY 1356
GYRQ+ +YIA+QGPL T EDFWRM+WE S +VMLT+L E G+EKC QYWP++ Y
Sbjct: 596 GYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSY 655
Query: 1357 QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQ 1416
V+ E Y +R+ VT+ R+ +SR +RQF F WPE G+P G+G I I
Sbjct: 656 GDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAA 715
Query: 1417 VHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAM 1476
V K ++Q G + PI+VHCSAG GRTG F LS VLER++ EG++D+FQTVK LR QRP M
Sbjct: 716 VQKQQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHM 774
Query: 1477 VQTEDQYQFSYRAALEYLGSFDHYA 1501
VQT +QY+F Y+ EY+ +F YA
Sbjct: 775 VQTLEQYEFCYKVVQEYIDAFSDYA 799
>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
precursor [Homo sapiens]
Length = 700
Score = 558 bits (1438), Expect = e-158
Identities = 298/658 (45%), Positives = 414/658 (62%), Gaps = 17/658 (2%)
Query: 853 LIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEIPSHHPTDPVELR 912
L W++ P+L ++ ++ ++A ++ + RK S S K +PN I V L
Sbjct: 48 LAWLLLPLLLLLLVL--LLAAYFFRFRKQRKAVVSTSDKK-MPNG--ILEEQEQQRVML- 101
Query: 913 RLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNK 971
L+ G + PIP+ L + I A+D +F +E+ S+ G Q T+E +N E N+
Sbjct: 102 -LSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENR 160
Query: 972 PKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWR 1031
KNRY N++ DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG ET DFWR
Sbjct: 161 EKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWR 220
Query: 1032 MIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALY 1091
M+WEQ+SAT+VM+T L+ER KC QYWP +G T+G ++V + D V L Y +R F +
Sbjct: 221 MVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQ 280
Query: 1092 K---NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVG 1148
+G R V Q FT+WPD GVP P L FL++VKT NP AGP+VVHCSAGVG
Sbjct: 281 PQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVG 340
Query: 1149 RTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNT 1208
RTG FIVIDAM+ + E+ VD++ V+ +R QR MVQT+ QY FI+ ALLE G+T
Sbjct: 341 RTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDT 400
Query: 1209 EVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNI 1268
E+ +L ++Q + T + G+E EF++L + + + NLP N K R++ I
Sbjct: 401 ELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQI 460
Query: 1269 MPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNST 1328
+PY+ RV L RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S
Sbjct: 461 IPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSH 520
Query: 1329 IVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DAR 1383
+VMLT+++E ++KC+QYWP E S + ++ + +R+F VT +
Sbjct: 521 TIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQ 580
Query: 1384 DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGV 1443
+ Q R VRQF F WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG
Sbjct: 581 EEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGT 639
Query: 1444 FITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1501
FI LS +LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+ +++ F YA
Sbjct: 640 FIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 697
>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
[Homo sapiens]
Length = 642
Score = 550 bits (1416), Expect = e-156
Identities = 282/591 (47%), Positives = 384/591 (64%), Gaps = 10/591 (1%)
Query: 920 GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYAN 978
G + PIP+ L + I A+D +F +E+ S+ G Q T+E +N E N+ KNRY N
Sbjct: 50 GPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPN 109
Query: 979 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1038
++ DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG ET DFWRM+WEQ+S
Sbjct: 110 ILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKS 169
Query: 1039 ATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK---NGS 1095
AT+VM+T L+ER KC QYWP +G T+G ++V + D V L Y +R F + +G
Sbjct: 170 ATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGC 229
Query: 1096 SEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIV 1155
R V Q FT+WPD GVP P L FL++VKT NP AGP+VVHCSAGVGRTG FIV
Sbjct: 230 KAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIV 289
Query: 1156 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNL 1215
IDAM+ + E+ VD++ V+ +R QR MVQT+ QY FI+ ALLE G+TE+ +L
Sbjct: 290 IDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSL 349
Query: 1216 YAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTR 1275
++Q + T + G+E EF++L + + + NLP N K R++ I+PY+ R
Sbjct: 350 EKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNR 409
Query: 1276 VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK 1335
V L RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +VMLT+
Sbjct: 410 VILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTE 469
Query: 1336 LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTV 1390
++E ++KC+QYWP E S + ++ + +R+F VT ++ Q R V
Sbjct: 470 VQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVV 529
Query: 1391 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1450
RQF F WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI LS +
Sbjct: 530 RQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNI 588
Query: 1451 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1501
LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+ +++ F YA
Sbjct: 589 LERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 513 bits (1322), Expect = e-145
Identities = 375/1161 (32%), Positives = 545/1161 (46%), Gaps = 161/1161 (13%)
Query: 462 NWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSD---IQVITQTGVPGQ-PL 517
+W DS IG+L P Y + VL T G+G S ++ T+ P + P
Sbjct: 326 SWNDRQPVDSTSYKIGHLDPDTEYEISVL-LTRPGEGGTGSPGPALRTRTKCADPMRGPR 384
Query: 518 NFKAEPESETSILLSWTP-------PRSDTIANYELVYKDGEHGEEQRITIEPGTSY--- 567
+ I + W P S + + G+ + ++ + S+
Sbjct: 385 KLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQH 444
Query: 568 RLQGLKPNSLYYFRLAARSPQGLGASTAEI--------SARTMQSMFAKNFHVKAVMKTS 619
+ L P + +L +P+G S I A +S+ F K
Sbjct: 445 TITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEK------ 498
Query: 620 VLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEKS 666
+ L W P + Y ++I Y + E+D G T L L P +
Sbjct: 499 IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTT 558
Query: 667 YSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVPA 719
YSF + T +G T +AP + PA+ +T L D +TV L P
Sbjct: 559 YSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHSR 614
Query: 720 NENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVELK 775
+ Y I++ + R K +K + P + LL +
Sbjct: 615 GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS----------------Q 658
Query: 776 PYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATS 830
Y AA F + FT+GD+K Y G+ N L + Y ++F A + E+K+
Sbjct: 659 YYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQ 718
Query: 831 PYSDPVVSMDLDPQPI--TDEEEGLIWVVGPVLAVVFIICIVIAILLYK----------- 877
+ + P+P TD + V+ +L V II + + +++ K
Sbjct: 719 VATKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKETM 777
Query: 878 ------------------------------------------SKPDRKRAESDSRKSSIP 895
S P ++++ +S+P
Sbjct: 778 SSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVP 837
Query: 896 NN-------------KEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKAN 942
N+ + H E + +QT + HP I + +L HI ++K
Sbjct: 838 NSYYPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQL--HPAIRVADLLQHITQMKCA 895
Query: 943 DNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVN 1002
+ F +EYES GQ W+ + + N+ KNRY N+IAYDHSRV L IEG SDY+N
Sbjct: 896 EGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYIN 955
Query: 1003 ANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSR 1062
NYIDGY + N YIATQG + ET DFWRM+W + +A+++M+T L E RVKC +YWP
Sbjct: 956 GNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD- 1014
Query: 1063 GTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFL 1122
TE + ++VTL++T LA Y +RTFA+ K G E RE+RQF FT WPDHGVP H T L
Sbjct: 1015 DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLL 1074
Query: 1123 AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQR 1182
F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+ + E VDIY V +R++R
Sbjct: 1075 GFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRR 1134
Query: 1183 NYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRL- 1241
MVQTE+QY+FIHDA+LEA CG+T VPA + + + +++ N + ++ EF+ L
Sbjct: 1135 VNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLN 1194
Query: 1242 -ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQ 1300
+ A LP N KNR ++I+P + L I G E S+YINA+ +D Y+Q
Sbjct: 1195 MVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQ 1253
Query: 1301 QKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP---AERSARYQ 1357
A+I TQ PL T +DFWR++ +++ T VVML + + C QYWP R Q
Sbjct: 1254 PSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQ 1311
Query: 1358 YFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQ 1416
V E ++ I R + +DG R V+QFQF WP + P S F+ I Q
Sbjct: 1312 VEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQ 1370
Query: 1417 VHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPA 1475
V K +E++ G +G VHC G GR+G F +SIV E +R++ VD+F VK LR +P
Sbjct: 1371 VDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPN 1430
Query: 1476 MVQTEDQYQFSYRAALEYLGS 1496
MV DQY+F Y ALEYL S
Sbjct: 1431 MVDLLDQYKFCYEVALEYLNS 1451
Score = 137 bits (344), Expect = 1e-31
Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 970 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1029
N KNR +++ D L I+G S+Y+NA +D Y++ +A+I TQ LP T DF
Sbjct: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271
Query: 1030 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1089
WR++ + +VVM+ ++ C QYWP G HG +QV + R F
Sbjct: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329
Query: 1090 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1143
+Y + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1330 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1389
Query: 1144 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1203
G GR+G F I + E ++H++TVD++ V +R + MV DQY F ++ LE +
Sbjct: 1390 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1449
Query: 1204 TCG 1206
G
Sbjct: 1450 NSG 1452
Score = 66.6 bits (161), Expect = 2e-10
Identities = 93/436 (21%), Positives = 165/436 (37%), Gaps = 61/436 (13%)
Query: 188 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEI-MP 246
+ + + + D GKY C+ G S A L V+E P S+ T I +
Sbjct: 244 SFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLN 303
Query: 247 GGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL- 305
S+N V + Y + D P+ ++ + Y + T
Sbjct: 304 ANSINGDGPIVAREVEYC-----TASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRP 358
Query: 306 ------GVIEAIAQITVKALP-KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPK 358
A+ T A P + P V E + IT+ W EP Y + +
Sbjct: 359 GEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRW-----EPFGYNVTRCHSY 413
Query: 359 N-----------SEELYKEIDGVATT---RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEP 404
N E++ +E+ ++++ LSPY++ +++ +N GR S+
Sbjct: 414 NLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-KESQE 472
Query: 405 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHV 460
++ QT E P + P + I +QW+EP + G I Y + Y + DP +
Sbjct: 473 LIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDL 532
Query: 461 NNWMKHNVADSQITTIGN--------LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 512
+N +++ +GN L P TYS + A T+ G GP +++ Q T+
Sbjct: 533 SN------QSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTTKISA 585
Query: 513 PGQPLNFKAEPESET----SILLSWTPPRSDTIANYELVYKDGEHGEEQRIT----IEPG 564
P P P ++T +++L R ++ Y++V ++ ++ T P
Sbjct: 586 PSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPV 645
Query: 565 TSYRLQGLKPNSLYYF 580
+ NS YYF
Sbjct: 646 PIHFQNASLLNSQYYF 661
Score = 63.9 bits (154), Expect = 1e-09
Identities = 95/401 (23%), Positives = 155/401 (38%), Gaps = 44/401 (10%)
Query: 241 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 291
N E+ G C A+G + + L D+ P ++ + R + N V
Sbjct: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
Query: 292 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 347
R + Y C+ + GV I A++ VK P P P + AT I L +S N + P
Sbjct: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
Query: 348 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 405
+ +++ + + + V +T Y + L P ++YE V+ G G P +
Sbjct: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370
Query: 406 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 461
T+T P PR ++ + S I ++W+ + Y + Y + + V
Sbjct: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430
Query: 462 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 519
+ + +S TI NL P SVK++ G S ++ V T +PG P
Sbjct: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489
Query: 520 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 566
E I L W P I YE+ YK + G ++ E T
Sbjct: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547
Query: 567 YRLQGLKPNSLYYFRLAARSPQGLGAS-----TAEISARTM 602
+ GL P + Y F + A + +G G T +ISA +M
Sbjct: 548 FLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSM 588
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 510 bits (1313), Expect = e-144
Identities = 379/1234 (30%), Positives = 581/1234 (47%), Gaps = 157/1234 (12%)
Query: 376 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 435
SVA + S ++R V ++ G G + L P + P L + W
Sbjct: 253 SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306
Query: 436 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 493
+P + G + ++ W + ++ DS + +L P Y ++VL
Sbjct: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366
Query: 494 SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 544
G GP + T+ P P N + + L W P + Y
Sbjct: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426
Query: 545 ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI------- 597
+ V+ ++ E+ I+ + Y L+GL+P RL +P+G S +
Sbjct: 427 QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDV 484
Query: 598 -SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA-- 653
A ++S+ F K + + W+ P N + ++I Y K V +D A
Sbjct: 485 PGAVPLESIQGGPFEEK------IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADL 535
Query: 654 -------------TQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPA 699
T L V L P +YSF + + ++A G VT + A + + P
Sbjct: 536 SSQRGKVFKLRNETHHLFVGLYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPE 593
Query: 700 FIGKTNL---DGMITVQLPEVPANENIKGYYIIIVP---LKKSRGK------FIKPWESP 747
+ T L D ITV L + Y ++V L+KSR F P
Sbjct: 594 YDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
Query: 748 DEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQS 807
+ LD L + ELKP A+ V FT+GD+K Y G+ N L
Sbjct: 654 NASSLDSL------------HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSP 697
Query: 808 GQEY-VFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFI 866
+ Y ++F + E+K+ + + + + + + + + G + ++
Sbjct: 698 LKSYSIYFQALSKANGETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMF 757
Query: 867 ICIVIAILL------------YKSKPDRKRAESDS----------------RKSSIPNNK 898
I I++ ++L Y K +K+ E+ S K S N
Sbjct: 758 IIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRND 817
Query: 899 E--------------------------IPSH--HPTDPVELRRLNFQTPGMASHPPIPIL 930
E I +H DPVE+ P P I +
Sbjct: 818 EGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIRVA 872
Query: 931 ELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLS 990
+L HI ++K F +EYE++ GQ +W+ + + N+ KNRY N+I+YDHSRV L
Sbjct: 873 DLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLL 932
Query: 991 AIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEER 1050
++G P SDY+NANYIDGY + YIATQG + ET DFWRMIW++ SA++VM+T L E
Sbjct: 933 VLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEV 992
Query: 1051 SRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWP 1110
RVKC +YWP TE +G ++VTL++T LA Y +RTF + K G E RE+R F FT+WP
Sbjct: 993 GRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWP 1051
Query: 1111 DHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVD 1170
DHGVP + T L F+R+VK NPP+AGP+VVHCSAG GRTGCFI ID ML+ ++E VD
Sbjct: 1052 DHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVD 1111
Query: 1171 IYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA---RNLYAYIQKLTQIET 1227
I+ V +RAQR +VQTE+QY+F+HDA+LEA CGNT +P R+LY I +L +T
Sbjct: 1112 IFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDP-QT 1170
Query: 1228 GENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS 1287
+ E + + + + LP N KNR ++++P + L + G E S
Sbjct: 1171 NSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESS 1229
Query: 1288 DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQY 1347
+YINA+ +D ++Q A++ TQ PL T DFWR+++++N + VVML ++ + C QY
Sbjct: 1230 NYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQY 1287
Query: 1348 WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVP 1404
WP + S Y V+ ++ I R F++ + Q R V+ Q+ WP + P
Sbjct: 1288 WPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTP 1347
Query: 1405 KSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF 1463
S + + ++ K +EQ+ G++G VHC G GR+G F + V E ++ + ++D+F
Sbjct: 1348 PSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVF 1407
Query: 1464 QTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF 1497
VK LR + MV+T +QY+F Y ALEYL SF
Sbjct: 1408 HIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1441
Score = 68.9 bits (167), Expect = 3e-11
Identities = 82/325 (25%), Positives = 133/325 (40%), Gaps = 34/325 (10%)
Query: 292 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 348
R + Y CV S G + A++ VK P P P E A T W N +
Sbjct: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316
Query: 349 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 404
+ + + + + + E V + Y + L P +YE RV+ G GPP P
Sbjct: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376
Query: 405 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 463
+ T+T P P++V+ + + + +QW EP G + Y Q+V N
Sbjct: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432
Query: 464 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 517
++ + S T+ L P T +++L S +G + S+ V+ T+ VPG PL
Sbjct: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490
Query: 518 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 570
E I + W PP + I YE+ YK G ++ + G ++L+
Sbjct: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550
Query: 571 ----GLKPNSLYYFRLAARSPQGLG 591
GL P + Y F + A + +G G
Sbjct: 551 HLFVGLYPGTTYSFTIKASTAKGFG 575
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 507 bits (1306), Expect = e-143
Identities = 303/770 (39%), Positives = 430/770 (55%), Gaps = 71/770 (9%)
Query: 786 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 840
P FT+GD++ Y GF N L + Y ++F E+K AT + +
Sbjct: 682 PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741
Query: 841 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEI 900
DP TD + + +L VFI+ +++ IL+ K K+ RK ++ N ++
Sbjct: 742 PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKLAKK-----RKDAMGNTRQE 794
Query: 901 PSH---------------HPTDPVEL----------RRLNFQTPGMAS------------ 923
+H H DP+ + R N +S
Sbjct: 795 MTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEG 854
Query: 924 ----------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPK 973
HP I + +L HI +K +D+ F +EYES GQ +W+ + + N+ K
Sbjct: 855 TESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAK 914
Query: 974 NRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMI 1033
NRY N+IAYDHSRV+L +E P SDY+NANYIDGY++ + YIATQG + ET DFWRMI
Sbjct: 915 NRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMI 974
Query: 1034 WEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKN 1093
W+++SA +VM+T L E RVKC +YWP TE +G +VT ++ LA Y VRTF L +
Sbjct: 975 WQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERR 1033
Query: 1094 GSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCF 1153
G +E REV+QF FT WPDHGVP H T L+F+RRVK NPP AGP+VVHCSAG GRTGC+
Sbjct: 1034 GYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCY 1093
Query: 1154 IVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPAR 1213
IVID ML+ + E VDIY V +R++R MVQTE+QYIFIHDA+LEA CG T +P
Sbjct: 1094 IVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVC 1153
Query: 1214 NLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLVNIMPY 1271
A + +I++ N + ++ EF+ L S + A LP N KNR ++++P
Sbjct: 1154 EFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPP 1213
Query: 1272 ESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVV 1331
+ L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR+++++ T +V
Sbjct: 1214 DRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIV 1272
Query: 1332 MLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQSR 1388
ML ++ + C QYWP E RY V+ M+ + ++ I R +T ++G
Sbjct: 1273 MLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY-L 1329
Query: 1389 TVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVFIT 1446
V+QFQ+ W + VP S F+ I QV K +E+ + +G +HC G GR+G+F
Sbjct: 1330 MVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCA 1389
Query: 1447 LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1496
+ IV+E ++ + VVD+F VK LR +P MV+ +QY+F Y ALEYL S
Sbjct: 1390 IGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
Score = 62.0 bits (149), Expect = 4e-09
Identities = 87/407 (21%), Positives = 158/407 (38%), Gaps = 62/407 (15%)
Query: 243 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 296
E+ G + C+A G + K L + +D+P+ + +N R +A+
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260
Query: 297 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 345
Y CV S G + AQ+ V+ P+P P + T + + ++ +
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Query: 346 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 403
P+ ++++ + + E V Y + L P ++YE RV+ G G P
Sbjct: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
Query: 404 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 461
P++T+T P P+ ++ + + I V W+ GY + +T + T +
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
Query: 462 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 512
+ HN + + + +L P S+K++ T+ S + + T V
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489
Query: 513 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 560
PG P+ E I L+W P + I YE+ Y G Q ++
Sbjct: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
Query: 561 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTA-----EISARTM 602
+ T + L P + Y F + A + +G G +TA ISA T+
Sbjct: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTL 596
Score = 58.9 bits (141), Expect = 4e-08
Identities = 92/400 (23%), Positives = 151/400 (37%), Gaps = 54/400 (13%)
Query: 188 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPG 247
+ ++++ ++DQ Y CV + G+ S A L VRE PPR PP + P
Sbjct: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE-------PPRPIAPPQLLGVGPT 306
Query: 248 G---SVNITCVAVGSP--MPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAM 302
+N + P + V++ + + T + + +L + Y +
Sbjct: 307 YLLIQLNANSIIGDGPIILKEVEYRMTSGSWT--ETHAVNAPTYKLWHLDPDTEYEIRVL 364
Query: 303 ST--------LGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS----------GN 344
T L I + + P T + E A I + W+S N
Sbjct: 365 LTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFN 424
Query: 345 PEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEP 404
+Y H ++ L ++D A ++ V L PY++ +++ N GR SE
Sbjct: 425 VTICYHYFRGHNESKADCL--DMDPKAP-QHVVNHLPPYTNVSLKMILTNPEGR-KESEE 480
Query: 405 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHV 460
+ QT E P P I + WKEP +PNG I Y + Y + DP V
Sbjct: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV 540
Query: 461 NN--WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP-- 516
N+ +S +L P TY + A T G GP ++ I V T P P
Sbjct: 541 AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDY 599
Query: 517 ------LNFKAEPESETSILLSWTPPRSDTIANYELVYKD 550
LN E + ++LL + I+ Y++V ++
Sbjct: 600 EGVDASLN---ETATTITVLLRPAQAKGAPISAYQIVVEE 636
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 501 bits (1291), Expect = e-141
Identities = 383/1256 (30%), Positives = 584/1256 (46%), Gaps = 182/1256 (14%)
Query: 376 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 435
SVA + S ++R V ++ G G + L P + P L + W
Sbjct: 253 SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306
Query: 436 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 493
+P + G + ++ W + ++ DS + +L P Y ++VL
Sbjct: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366
Query: 494 SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 544
G GP + T+ P P N + + L W P + Y
Sbjct: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426
Query: 545 ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI------- 597
+ V+ ++ E+ I+ + Y L+GL+P RL +P+G S +
Sbjct: 427 QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDV 484
Query: 598 -SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA-- 653
A ++S+ F K + + W+ P N + ++I Y K V +D A
Sbjct: 485 PGAVPLESIQGGPFEEK------IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADL 535
Query: 654 -------------TQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPA 699
T L V L P +YSF + + ++A G VT + A + + P
Sbjct: 536 SSQRGKVFKLRNETHHLFVGLYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPE 593
Query: 700 FIGKTNL---DGMITVQLPEVPANENIKGYYIIIVP---LKKSRGK------FIKPWESP 747
+ T L D ITV L + Y ++V L+KSR F P
Sbjct: 594 YDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
Query: 748 DEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQS 807
+ LD L + ELKP A+ V FT+GD+K Y G+ N L
Sbjct: 654 NASSLDSL------------HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSP 697
Query: 808 GQEY-VFFVLAVMEHAES-----KMYATSPYSDPVV-----------------SMDLDPQ 844
+ Y ++F + E+ ++ +P V S ++P+
Sbjct: 698 LKSYSIYFQALSKANGETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPE 757
Query: 845 PITDEEEGLIWVVGPVLAVVFIICIVIAILL------------YKSKPDRKRAESDS--- 889
D + + G + ++ I I++ ++L Y K +K+ E+ S
Sbjct: 758 KQVDNT---VKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQ 814
Query: 890 -------------RKSSIPNNKE--------------------------IPSH--HPTDP 908
K S N E I +H DP
Sbjct: 815 REMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDP 874
Query: 909 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLE 968
VE+ P P I + +L HI ++K F +EYE++ GQ +W+ + +
Sbjct: 875 VEM-----SYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKED 929
Query: 969 VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGD 1028
N+ KNRY N+I+YDHSRV L ++G P SDY+NANYIDGY + YIATQG + ET D
Sbjct: 930 ENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKD 989
Query: 1029 FWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTF 1088
FWRMIW++ SA++VM+T L E RVKC +YWP TE +G ++VTL++T LA Y +RTF
Sbjct: 990 FWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTF 1048
Query: 1089 ALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVG 1148
+ K G E RE+R F FT+WPDHGVP + T L F+R+VK NPP+AGP+VVHCSAG G
Sbjct: 1049 TVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAG 1108
Query: 1149 RTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNT 1208
RTGCFI ID ML+ ++E VDI+ V +RAQR +VQTE+QY+F+HDA+LEA CGNT
Sbjct: 1109 RTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNT 1168
Query: 1209 EVPA---RNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRL 1265
+P R+LY I +L +T + E + + + + LP N KNR
Sbjct: 1169 AIPVCEFRSLYYNISRLDP-QTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRS 1227
Query: 1266 VNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEH 1325
++++P + L + G E S+YINA+ +D ++Q A++ TQ PL T DFWR+++++
Sbjct: 1228 MDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDY 1286
Query: 1326 NSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDG 1385
N + VVML ++ + C QYWP + S Y V+ ++ I R F++ +
Sbjct: 1287 NCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARP 1344
Query: 1386 QS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRT 1441
Q R V+ Q+ WP + P S + + ++ K +EQ+ G++G VHC G GR+
Sbjct: 1345 QDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRS 1404
Query: 1442 GVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF 1497
G F + V E ++ + ++D+F VK LR + MV+T +QY+F Y ALEYL SF
Sbjct: 1405 GTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1460
Score = 68.9 bits (167), Expect = 3e-11
Identities = 82/325 (25%), Positives = 133/325 (40%), Gaps = 34/325 (10%)
Query: 292 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 348
R + Y CV S G + A++ VK P P P E A T W N +
Sbjct: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316
Query: 349 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 404
+ + + + + + E V + Y + L P +YE RV+ G GPP P
Sbjct: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376
Query: 405 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 463
+ T+T P P++V+ + + + +QW EP G + Y Q+V N
Sbjct: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432
Query: 464 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 517
++ + S T+ L P T +++L S +G + S+ V+ T+ VPG PL
Sbjct: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490
Query: 518 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 570
E I + W PP + I YE+ YK G ++ + G ++L+
Sbjct: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550
Query: 571 ----GLKPNSLYYFRLAARSPQGLG 591
GL P + Y F + A + +G G
Sbjct: 551 HLFVGLYPGTTYSFTIKASTAKGFG 575
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 501 bits (1289), Expect = e-141
Identities = 303/776 (39%), Positives = 430/776 (55%), Gaps = 77/776 (9%)
Query: 786 PTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMY----ATSPYSDPVVSMD 840
P FT+GD++ Y GF N L + Y ++F E+K AT + +
Sbjct: 682 PAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI 741
Query: 841 LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEI 900
DP TD + + +L VFI+ +++ IL+ K K+ RK ++ N ++
Sbjct: 742 PDPAKQTDRVVKIAGISAGIL--VFILLLLVVILIVKKSKLAKK-----RKDAMGNTRQE 794
Query: 901 PSH---------------HPTDPVEL----------RRLNFQTPGMAS------------ 923
+H H DP+ + R N +S
Sbjct: 795 MTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEG 854
Query: 924 ----------HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPK 973
HP I + +L HI +K +D+ F +EYES GQ +W+ + + N+ K
Sbjct: 855 TESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAK 914
Query: 974 NRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSLPETFG 1027
NRY N+IAYDHSRV+L +E P SDY+NANYID GY++ + YIATQG + ET
Sbjct: 915 NRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVY 974
Query: 1028 DFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRT 1087
DFWRMIW+++SA +VM+T L E RVKC +YWP TE +G +VT ++ LA Y VRT
Sbjct: 975 DFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRT 1033
Query: 1088 FALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGV 1147
F L + G +E REV+QF FT WPDHGVP H T L+F+RRVK NPP AGP+VVHCSAG
Sbjct: 1034 FTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGA 1093
Query: 1148 GRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGN 1207
GRTGC+IVID ML+ + E VDIY V +R++R MVQTE+QYIFIHDA+LEA CG
Sbjct: 1094 GRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGE 1153
Query: 1208 TEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRL 1265
T +P A + +I++ N + ++ EF+ L S + A LP N KNR
Sbjct: 1154 TAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRF 1213
Query: 1266 VNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEH 1325
++++P + L I G E S+YINA+ +D YRQ A+I TQ PL T +DFWR+++++
Sbjct: 1214 MDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDY 1272
Query: 1326 NSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA---EYNMPQYILREFKVTDA 1382
T +VML ++ + C QYWP E RY V+ M+ + ++ I R +T
Sbjct: 1273 GCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRP 1330
Query: 1383 RDGQSRTVRQFQFTDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGR 1440
++G V+QFQ+ W + VP S F+ I QV K +E+ + +G +HC G GR
Sbjct: 1331 QEGY-LMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGR 1389
Query: 1441 TGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1496
+G+F + IV+E ++ + VVD+F VK LR +P MV+ +QY+F Y ALEYL S
Sbjct: 1390 SGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445
Score = 62.0 bits (149), Expect = 4e-09
Identities = 87/407 (21%), Positives = 158/407 (38%), Gaps = 62/407 (15%)
Query: 243 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN------ 296
E+ G + C+A G + K L + +D+P+ + +N R +A+
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRN---GEDIPVAQTK-NINHRRFAASFRLQEV 260
Query: 297 -------YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---P 345
Y CV S G + AQ+ V+ P+P P + T + + ++ +
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320
Query: 346 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSE 403
P+ ++++ + + E V Y + L P ++YE RV+ G G P
Sbjct: 321 GPIILKEVEYRMTSGS--WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378
Query: 404 PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV--YYTMDPTQHVN 461
P++T+T P P+ ++ + + I V W+ GY + +T + T +
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430
Query: 462 NWMKHNVADSQIT---------TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 512
+ HN + + + +L P S+K++ T+ S + + T V
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMI-LTNPEGRKESEETIIQTDEDV 489
Query: 513 PGQ-PLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEH--------GEEQRIT- 560
PG P+ E I L+W P + I YE+ Y G Q ++
Sbjct: 490 PGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSN 549
Query: 561 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTA-----EISARTM 602
+ T + L P + Y F + A + +G G +TA ISA T+
Sbjct: 550 LWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTL 596
Score = 58.9 bits (141), Expect = 4e-08
Identities = 92/400 (23%), Positives = 151/400 (37%), Gaps = 54/400 (13%)
Query: 188 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPG 247
+ ++++ ++DQ Y CV + G+ S A L VRE PPR PP + P
Sbjct: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE-------PPRPIAPPQLLGVGPT 306
Query: 248 G---SVNITCVAVGSP--MPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAM 302
+N + P + V++ + + T + + +L + Y +
Sbjct: 307 YLLIQLNANSIIGDGPIILKEVEYRMTSGSWT--ETHAVNAPTYKLWHLDPDTEYEIRVL 364
Query: 303 ST--------LGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS----------GN 344
T L I + + P T + E A I + W+S N
Sbjct: 365 LTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFN 424
Query: 345 PEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEP 404
+Y H ++ L ++D A ++ V L PY++ +++ N GR SE
Sbjct: 425 VTICYHYFRGHNESKADCL--DMDPKAP-QHVVNHLPPYTNVSLKMILTNPEGR-KESEE 480
Query: 405 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHV 460
+ QT E P P I + WKEP +PNG I Y + Y + DP V
Sbjct: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV 540
Query: 461 NN--WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP-- 516
N+ +S +L P TY + A T G GP ++ I V T P P
Sbjct: 541 AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTTNISAPTLPDY 599
Query: 517 ------LNFKAEPESETSILLSWTPPRSDTIANYELVYKD 550
LN E + ++LL + I+ Y++V ++
Sbjct: 600 EGVDASLN---ETATTITVLLRPAQAKGAPISAYQIVVEE 636
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 498 bits (1282), Expect = e-140
Identities = 266/580 (45%), Positives = 357/580 (61%), Gaps = 12/580 (2%)
Query: 924 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 983
HP I + +L HI ++K + F +EYES GQ W+ + + N+ KNRY N+IAYD
Sbjct: 890 HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYD 949
Query: 984 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1043
HSRV L IEG SDY+N NYIDGY + N YIATQG + ET DFWRM+W + +A+++M
Sbjct: 950 HSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 1009
Query: 1044 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1103
+T L E RVKC +YWP TE + ++VTL++T LA Y +RTFA+ K G E RE+RQ
Sbjct: 1010 VTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQ 1068
Query: 1104 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1163
F FT WPDHGVP H T L F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+
Sbjct: 1069 FHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMA 1128
Query: 1164 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1223
+ E VDIY V +R++R MVQTE+QY+FIHDA+LEA CG+T VPA + + +
Sbjct: 1129 EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMN 1188
Query: 1224 QIETGENVTGMELEFKRL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1281
+++ N + ++ EF+ L + A LP N KNR ++I+P + L I
Sbjct: 1189 KLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI 1248
Query: 1282 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1341
G E S+YINA+ +D Y+Q A+I TQ PL T +DFWR++ +++ T VVML +
Sbjct: 1249 DG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--A 1305
Query: 1342 EKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1398
+ C QYWP R Q V E ++ I R + +DG R V+QFQF W
Sbjct: 1306 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGW 1364
Query: 1399 P-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1456
P + P S F+ I QV K +E++ G +G VHC G GR+G F +SIV E +R+
Sbjct: 1365 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1424
Query: 1457 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1496
+ VD+F VK LR +P MV DQY+F Y ALEYL S
Sbjct: 1425 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464
Score = 137 bits (344), Expect = 1e-31
Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 970 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1029
N KNR +++ D L I+G S+Y+NA +D Y++ +A+I TQ LP T DF
Sbjct: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284
Query: 1030 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1089
WR++ + +VVM+ ++ C QYWP G HG +QV + R F
Sbjct: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342
Query: 1090 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1143
+Y + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1343 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1402
Query: 1144 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1203
G GR+G F I + E ++H++TVD++ V +R + MV DQY F ++ LE +
Sbjct: 1403 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1462
Query: 1204 TCG 1206
G
Sbjct: 1463 NSG 1465
Score = 66.6 bits (161), Expect = 2e-10
Identities = 93/436 (21%), Positives = 165/436 (37%), Gaps = 61/436 (13%)
Query: 188 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEI-MP 246
+ + + + D GKY C+ G S A L V+E P S+ T I +
Sbjct: 244 SFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLN 303
Query: 247 GGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTL- 305
S+N V + Y + D P+ ++ + Y + T
Sbjct: 304 ANSINGDGPIVAREVEYC-----TASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRP 358
Query: 306 ------GVIEAIAQITVKALP-KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPK 358
A+ T A P + P V E + IT+ W EP Y + +
Sbjct: 359 GEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRW-----EPFGYNVTRCHSY 413
Query: 359 N-----------SEELYKEIDGVATT---RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEP 404
N E++ +E+ ++++ LSPY++ +++ +N GR S+
Sbjct: 414 NLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-KESQE 472
Query: 405 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHV 460
++ QT E P + P + I +QW+EP + G I Y + Y + DP +
Sbjct: 473 LIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDL 532
Query: 461 NNWMKHNVADSQITTIGN--------LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 512
+N +++ +GN L P TYS + A T+ G GP +++ Q T+
Sbjct: 533 SN------QSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTTKISA 585
Query: 513 PGQPLNFKAEPESET----SILLSWTPPRSDTIANYELVYKDGEHGEEQRIT----IEPG 564
P P P ++T +++L R ++ Y++V ++ ++ T P
Sbjct: 586 PSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPV 645
Query: 565 TSYRLQGLKPNSLYYF 580
+ NS YYF
Sbjct: 646 PIHFQNASLLNSQYYF 661
Score = 63.9 bits (154), Expect = 1e-09
Identities = 95/401 (23%), Positives = 155/401 (38%), Gaps = 44/401 (10%)
Query: 241 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 291
N E+ G C A+G + + L D+ P ++ + R + N V
Sbjct: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
Query: 292 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 347
R + Y C+ + GV I A++ VK P P P + AT I L +S N + P
Sbjct: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
Query: 348 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 405
+ +++ + + + V +T Y + L P ++YE V+ G G P +
Sbjct: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370
Query: 406 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 461
T+T P PR ++ + S I ++W+ + Y + Y + + V
Sbjct: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430
Query: 462 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 519
+ + +S TI NL P SVK++ G S ++ V T +PG P
Sbjct: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489
Query: 520 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 566
E I L W P I YE+ YK + G ++ E T
Sbjct: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547
Query: 567 YRLQGLKPNSLYYFRLAARSPQGLGAS-----TAEISARTM 602
+ GL P + Y F + A + +G G T +ISA +M
Sbjct: 548 FLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSM 588
Score = 51.2 bits (121), Expect = 7e-06
Identities = 105/481 (21%), Positives = 175/481 (36%), Gaps = 81/481 (16%)
Query: 462 NWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSD---IQVITQTGVPGQ-PL 517
+W DS IG+L P Y + VL T G+G S ++ T+ P + P
Sbjct: 326 SWNDRQPVDSTSYKIGHLDPDTEYEISVL-LTRPGEGGTGSPGPALRTRTKCADPMRGPR 384
Query: 518 NFKAEPESETSILLSWTP-------PRSDTIANYELVYKDGEHGEEQRITIEPGTSY--- 567
+ I + W P S + + G+ + ++ + S+
Sbjct: 385 KLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQH 444
Query: 568 RLQGLKPNSLYYFRLAARSPQGLGASTAEI--------SARTMQSMFAKNFHVKAVMKTS 619
+ L P + +L +P+G S I A +S+ F K
Sbjct: 445 TITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEK------ 498
Query: 620 VLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEKS 666
+ L W P + Y ++I Y + E+D G T L L P +
Sbjct: 499 IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTT 558
Query: 667 YSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVPA 719
YSF + T +G T +AP + PA+ +T L D +TV L P
Sbjct: 559 YSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHSR 614
Query: 720 NENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVELK 775
+ Y I++ + R K +K + P + LL +
Sbjct: 615 GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS----------------Q 658
Query: 776 PYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATS 830
Y AA F + FT+GD+K Y G+ N L + Y ++F A + E+K+
Sbjct: 659 YYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQ 718
Query: 831 PYSDPVVSMDLDPQP--ITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESD 888
+ + P+P TD + V+ +L V II + + +++ K K +KR E+
Sbjct: 719 VATKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKETM 777
Query: 889 S 889
S
Sbjct: 778 S 778
>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
precursor [Homo sapiens]
Length = 1436
Score = 469 bits (1208), Expect = e-132
Identities = 358/1134 (31%), Positives = 525/1134 (46%), Gaps = 136/1134 (11%)
Query: 463 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 520
W + + Q + +L P Y + VL T GDG TG PG PL +
Sbjct: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
Query: 521 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 558
AEP + L W P R T L Y H + R
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
Query: 559 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGL--GASTAEISARTMQSMFAKNFHVKAV 615
+ E G S Y ++ L P + RL +P+G G + + S A
Sbjct: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
Query: 616 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 662
++ + L WE P+ N + ++I Y + V G T + NL
Sbjct: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
Query: 663 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 717
P +Y F + T +G L T +AP P+ +G++ + ITV L P
Sbjct: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
Query: 718 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 776
I Y +I+ ++ R + ++ + L E + R + Y G E+
Sbjct: 617 GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
Query: 777 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 835
A FT+GD++ Y GF N L+ + Y ++F A E+++
Sbjct: 674 LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
Query: 836 VVSMDLDPQPITD--EEEGLIW-VVGPVLAVVFIICIVIAILLYKSKP------------ 880
P ++ EE GLI + LAV+ ++ I +++ K KP
Sbjct: 728 ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQ 787
Query: 881 ---------DRKRAES-----------------------DSRKSSIPNNKEIPSHHPTDP 908
DR + D R + + P P
Sbjct: 788 EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRP 847
Query: 909 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLE 968
+ + T + HP + + +L HI ++K + F QEYES G W+ + +
Sbjct: 848 CGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKK 901
Query: 969 VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGD 1028
+R + AYD RV L + G P +DY+NANYIDGY + N +IATQG PE D
Sbjct: 902 DKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYD 961
Query: 1029 FWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTF 1088
FWRM+W++ +++VM+TKL E RVKC +YWP ++T+G +++ L+ T LA Y VRTF
Sbjct: 962 FWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTF 1020
Query: 1089 ALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVG 1148
AL + G S + EVRQF FTAWP+HGVP H T LAF+RRVK PPDAGP+V+HCSAG G
Sbjct: 1021 ALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTG 1080
Query: 1149 RTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNT 1208
RTGC+IV+D ML+ + E VDIY V + ++R M+QTE+QYIFIHDA+LEA CG T
Sbjct: 1081 RTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGET 1140
Query: 1209 EVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNKFKNRLV 1266
+P A +++ +I+ N + + EF+ L S A LP N+ KNR +
Sbjct: 1141 TIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSM 1200
Query: 1267 NIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE 1324
+++P + CL + +G ++YINA+ D Y + A+I T PL TT DFWR++++
Sbjct: 1201 DVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYD 1257
Query: 1325 HNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR 1383
+ T +VML +L + C QYWP +Y V+ M+ + R F+V +
Sbjct: 1258 YGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNIS 1317
Query: 1384 DGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGR 1440
Q VR FQF W + P S + F+ + +V K + + G DG VHC G GR
Sbjct: 1318 RLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGR 1376
Query: 1441 TGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1494
+G F + VLE +R +VD+F K LR +P MV+T DQY F Y ALEYL
Sbjct: 1377 SGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1430
Score = 62.8 bits (151), Expect = 2e-09
Identities = 76/342 (22%), Positives = 136/342 (39%), Gaps = 43/342 (12%)
Query: 297 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 352
Y CV+ + G + A++ VK P P P + + T + + ++ + P+
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Query: 353 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 410
I+++ + E+ V+ Y + L P ++YE V+ + G G P P++++T
Sbjct: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
Query: 411 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 470
P AP+ + + + + +QW EP G YT+ H HN
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
Query: 471 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 516
+ TI NL+P + V+++ G + +D V +G+ +
Sbjct: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
Query: 517 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 565
L F E I L W P+ + I YE+ Y+ E G + I+ + T
Sbjct: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
Query: 566 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSMF 606
+ L P + Y F + AR+ +G G A+ EI+ F
Sbjct: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF 592
Score = 62.4 bits (150), Expect = 3e-09
Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)
Query: 362 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 421
E K GV+ RY++ L PY + R+V N GR E V QT E PS +
Sbjct: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
Query: 422 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 475
I ++W+EP+EPNG I Y + Y + DP +V + + +
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
Query: 476 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 528
NL P TY V A T G G ++ ++ T P PL E E+ +
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
Query: 529 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 564
+LL R I+ Y+++ E +R+ EPG
Sbjct: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
precursor [Homo sapiens]
Length = 1442
Score = 463 bits (1191), Expect = e-130
Identities = 358/1140 (31%), Positives = 525/1140 (46%), Gaps = 142/1140 (12%)
Query: 463 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 520
W + + Q + +L P Y + VL T GDG TG PG PL +
Sbjct: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
Query: 521 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 558
AEP + L W P R T L Y H + R
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
Query: 559 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGL--GASTAEISARTMQSMFAKNFHVKAV 615
+ E G S Y ++ L P + RL +P+G G + + S A
Sbjct: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
Query: 616 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 662
++ + L WE P+ N + ++I Y + V G T + NL
Sbjct: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
Query: 663 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 717
P +Y F + T +G L T +AP P+ +G++ + ITV L P
Sbjct: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
Query: 718 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 776
I Y +I+ ++ R + ++ + L E + R + Y G E+
Sbjct: 617 GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
Query: 777 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 835
A FT+GD++ Y GF N L+ + Y ++F A E+++
Sbjct: 674 LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
Query: 836 VVSMDLDPQPITD--EEEGLIW-VVGPVLAVVFIICIVIAILLYKSKP------------ 880
P ++ EE GLI + LAV+ ++ I +++ K KP
Sbjct: 728 ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQ 787
Query: 881 ---------DRKRAES-----------------------DSRKSSIPNNKEIPSHHPTDP 908
DR + D R + + P P
Sbjct: 788 EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRP 847
Query: 909 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLE 968
+ + T + HP + + +L HI ++K + F QEYES G W+ + +
Sbjct: 848 CGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKK 901
Query: 969 VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSL 1022
+R + AYD RV L + G P +DY+NANYID GY + N +IATQG
Sbjct: 902 DKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPK 961
Query: 1023 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1082
PE DFWRM+W++ +++VM+TKL E RVKC +YWP ++T+G +++ L+ T LA
Sbjct: 962 PEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAE 1020
Query: 1083 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVH 1142
Y VRTFAL + G S + EVRQF FTAWP+HGVP H T LAF+RRVK PPDAGP+V+H
Sbjct: 1021 YVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIH 1080
Query: 1143 CSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEA 1202
CSAG GRTGC+IV+D ML+ + E VDIY V + ++R M+QTE+QYIFIHDA+LEA
Sbjct: 1081 CSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA 1140
Query: 1203 VTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNK 1260
CG T +P A +++ +I+ N + + EF+ L S A LP N+
Sbjct: 1141 CLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR 1200
Query: 1261 FKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDF 1318
KNR ++++P + CL + +G ++YINA+ D Y + A+I T PL TT DF
Sbjct: 1201 DKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDF 1257
Query: 1319 WRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1377
WR+++++ T +VML +L + C QYWP +Y V+ M+ + R F
Sbjct: 1258 WRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVF 1317
Query: 1378 KVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC 1434
+V + Q VR FQF W + P S + F+ + +V K + + G DG VHC
Sbjct: 1318 RVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHC 1376
Query: 1435 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1494
G GR+G F + VLE +R +VD+F K LR +P MV+T DQY F Y ALEYL
Sbjct: 1377 LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1436
Score = 62.8 bits (151), Expect = 2e-09
Identities = 76/342 (22%), Positives = 136/342 (39%), Gaps = 43/342 (12%)
Query: 297 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 352
Y CV+ + G + A++ VK P P P + + T + + ++ + P+
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Query: 353 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 410
I+++ + E+ V+ Y + L P ++YE V+ + G G P P++++T
Sbjct: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
Query: 411 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 470
P AP+ + + + + +QW EP G YT+ H HN
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
Query: 471 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 516
+ TI NL+P + V+++ G + +D V +G+ +
Sbjct: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
Query: 517 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 565
L F E I L W P+ + I YE+ Y+ E G + I+ + T
Sbjct: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
Query: 566 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSMF 606
+ L P + Y F + AR+ +G G A+ EI+ F
Sbjct: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF 592
Score = 62.4 bits (150), Expect = 3e-09
Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)
Query: 362 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 421
E K GV+ RY++ L PY + R+V N GR E V QT E PS +
Sbjct: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
Query: 422 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 475
I ++W+EP+EPNG I Y + Y + DP +V + + +
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
Query: 476 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 528
NL P TY V A T G G ++ ++ T P PL E E+ +
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
Query: 529 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 564
+LL R I+ Y+++ E +R+ EPG
Sbjct: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
precursor [Homo sapiens]
Length = 1446
Score = 462 bits (1188), Expect = e-129
Identities = 357/1144 (31%), Positives = 525/1144 (45%), Gaps = 146/1144 (12%)
Query: 463 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 520
W + + Q + +L P Y + VL T GDG TG PG PL +
Sbjct: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
Query: 521 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 558
AEP + L W P R T L Y H + R
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
Query: 559 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGL--GASTAEISARTMQSMFAKNFHVKAV 615
+ E G S Y ++ L P + RL +P+G G + + S A
Sbjct: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
Query: 616 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 662
++ + L WE P+ N + ++I Y + V G T + NL
Sbjct: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
Query: 663 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 717
P +Y F + T +G L T +AP P+ +G++ + ITV L P
Sbjct: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
Query: 718 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 776
I Y +I+ ++ R + ++ + L E + R + Y G E+
Sbjct: 617 GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
Query: 777 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 835
A FT+GD++ Y GF N L+ + Y ++F A E+++
Sbjct: 674 LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
Query: 836 VVSMDLDPQPITD--EEEGLIWVV--GPVLAVVFIICIVIAILL---------YKSKP-- 880
P ++ EE GLI + G + ++ ++ +I I+ Y KP
Sbjct: 728 ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYSYYPKPVN 787
Query: 881 -------------------DRKRAES-----------------------DSRKSSIPNNK 898
DR + D R +
Sbjct: 788 MTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEAS 847
Query: 899 EIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ 958
+ P P + + T + HP + + +L HI ++K + F QEYES G
Sbjct: 848 SLLGGSPRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG- 904
Query: 959 QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIAT 1018
W+ + + +R + AYD RV L + G P +DY+NANYIDGY + N +IAT
Sbjct: 905 ---WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIAT 961
Query: 1019 QGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTV 1078
QG PE DFWRM+W++ +++VM+TKL E RVKC +YWP ++T+G +++ L+ T
Sbjct: 962 QGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTE 1020
Query: 1079 ELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGP 1138
LA Y VRTFAL + G S + EVRQF FTAWP+HGVP H T LAF+RRVK PPDAGP
Sbjct: 1021 TLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGP 1080
Query: 1139 MVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDA 1198
+V+HCSAG GRTGC+IV+D ML+ + E VDIY V + ++R M+QTE+QYIFIHDA
Sbjct: 1081 IVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA 1140
Query: 1199 LLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANL 1256
+LEA CG T +P A +++ +I+ N + + EF+ L S A L
Sbjct: 1141 ILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALL 1200
Query: 1257 PCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAET 1314
P N+ KNR ++++P + CL + +G ++YINA+ D Y + A+I T PL T
Sbjct: 1201 PRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQST 1257
Query: 1315 TEDFWRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYI 1373
T DFWR+++++ T +VML +L + C QYWP +Y V+ M+ +
Sbjct: 1258 TPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLV 1317
Query: 1374 LREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1430
R F+V + Q VR FQF W + P S + F+ + +V K + + G DG
Sbjct: 1318 ARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRT 1376
Query: 1431 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1490
VHC G GR+G F + VLE +R +VD+F K LR +P MV+T DQY F Y A
Sbjct: 1377 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1436
Query: 1491 LEYL 1494
LEYL
Sbjct: 1437 LEYL 1440
Score = 62.8 bits (151), Expect = 2e-09
Identities = 76/342 (22%), Positives = 136/342 (39%), Gaps = 43/342 (12%)
Query: 297 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 352
Y CV+ + G + A++ VK P P P + + T + + ++ + P+
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Query: 353 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 410
I+++ + E+ V+ Y + L P ++YE V+ + G G P P++++T
Sbjct: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
Query: 411 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 470
P AP+ + + + + +QW EP G YT+ H HN
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
Query: 471 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 516
+ TI NL+P + V+++ G + +D V +G+ +
Sbjct: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
Query: 517 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 565
L F E I L W P+ + I YE+ Y+ E G + I+ + T
Sbjct: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
Query: 566 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSMF 606
+ L P + Y F + AR+ +G G A+ EI+ F
Sbjct: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF 592
Score = 62.4 bits (150), Expect = 3e-09
Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)
Query: 362 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 421
E K GV+ RY++ L PY + R+V N GR E V QT E PS +
Sbjct: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
Query: 422 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 475
I ++W+EP+EPNG I Y + Y + DP +V + + +
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
Query: 476 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 528
NL P TY V A T G G ++ ++ T P PL E E+ +
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
Query: 529 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 564
+LL R I+ Y+++ E +R+ EPG
Sbjct: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 458 bits (1179), Expect = e-128
Identities = 249/592 (42%), Positives = 343/592 (57%), Gaps = 28/592 (4%)
Query: 927 IPILELADHIERLKANDNLKFSQEYESID---PGQQFTWEHSNLEVNKPKNRYANVIAYD 983
IP+ + HI L +N+ FS+++E + T EHSN NK KNRY N++AYD
Sbjct: 828 IPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYD 887
Query: 984 HSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATV 1041
HSRV L + G SDY+NANY+DGY K AYIATQG L TF DFWRMIWEQ + +
Sbjct: 888 HSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGII 947
Query: 1042 VMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKN-------- 1093
VM+T L E+ R KCDQYWP+ +E +G + VTL T A Y VR F++
Sbjct: 948 VMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKG 1007
Query: 1094 ---GSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRT 1150
G +R V Q+ +T WPD GVPE+ P L F+RR P+ GP++VHCSAGVGRT
Sbjct: 1008 NPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRT 1067
Query: 1151 GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV 1210
G +IVID+ML++IK + TV++ G + +R QRNY+VQTE+QYIFIHDALLEA+ TEV
Sbjct: 1068 GTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEV 1127
Query: 1211 PARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMP 1270
+ L++Y+ + G T +E +FK + A SA CNK KNR +++P
Sbjct: 1128 SSNQLHSYVNSILIPGVG-GKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVP 1186
Query: 1271 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV 1330
E RV L P+ G++G+DYINAS+I GY + +I TQ PL TT+DFWRM+W+HN+ I+
Sbjct: 1187 SERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQII 1246
Query: 1331 VMLTKLREMGREKCHQYWPA-ERSARYQYFVV-----DPMAEYNMPQYILREFKVTDARD 1384
VML + + ++ YWP+ E S + F V D + N Q I+ +F + +D
Sbjct: 1247 VMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQD 1305
Query: 1385 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVF 1444
VR FQ WP P S + I + +E +DGP VH G G+
Sbjct: 1306 DYVLEVRHFQCPKWPNPDAPISST--FELINVI--KEEALTRDGPTIVHDEYGAVSAGML 1361
Query: 1445 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1496
L+ + +++ E VD+FQ KM+ RP + +QYQF Y+A L + +
Sbjct: 1362 CALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST 1413
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 424 bits (1089), Expect = e-118
Identities = 245/615 (39%), Positives = 345/615 (56%), Gaps = 43/615 (6%)
Query: 918 TPGMASHPPIPILELAD------------HIERLKANDNL--------KFSQEYESIDPG 957
+P + S PP PI ++D H+ L A+ +F QE +S
Sbjct: 1678 SPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVD 1737
Query: 958 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAY 1015
T + SN NK KNRY N++AYDHSRV L+ + G +DY+NANY+DGY + AY
Sbjct: 1738 LGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAY 1797
Query: 1016 IATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLL 1075
IA QG L T DFWRMIWE +VM+T L E+ R KCDQYWP+ G+E +G VT
Sbjct: 1798 IAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQK 1857
Query: 1076 DTVELATYCVRTFAL----YKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFLAFLRR 1127
LA Y VR F L K GS + R V Q+ +T WPD GVPE+ P L F+R+
Sbjct: 1858 SVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRK 1917
Query: 1128 VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ 1187
GP+VVHCSAGVGRTG +IV+D+ML++I+HE TV+I+G + +R+QRNY+VQ
Sbjct: 1918 AAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQ 1977
Query: 1188 TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAH 1247
TE+QY+FIHD L+EA+ TEV +++AY+ L I T +E +F+ L+ S
Sbjct: 1978 TEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALL-IPGPAGKTKLEKQFQLLSQSNIQ 2036
Query: 1248 TSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIAT 1307
S + +A CN+ KNR +I+P E +RV + + G EG+DYINAS+I GY Q +I T
Sbjct: 2037 QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIIT 2095
Query: 1308 QGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE 1366
Q PL T +DFWRM+W+HN+ +VVM+ + M ++ YWP + + F V MAE
Sbjct: 2096 QHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAE 2154
Query: 1367 -----YNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTK 1421
N + I+++F + +D VR FQ WP P S + I + +
Sbjct: 2155 EHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVI--KE 2210
Query: 1422 EQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED 1481
E +DGP+ VH G G F L+ ++ ++ E VD++Q KM+ RP + +
Sbjct: 2211 EAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIE 2270
Query: 1482 QYQFSYRAALEYLGS 1496
QYQF Y+ L + +
Sbjct: 2271 QYQFLYKVILSLVST 2285
Score = 115 bits (288), Expect = 3e-25
Identities = 77/264 (29%), Positives = 129/264 (48%), Gaps = 10/264 (3%)
Query: 958 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIA 1017
QQ + + + N+ KNR +++I + SRV +S++ G G+DY+NA+YI GY + N +I
Sbjct: 2036 QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFII 2094
Query: 1018 TQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH-GLVQVTLLD 1076
TQ L T DFWRMIW+ + VVM+ + + + YWP++ + +VTL+
Sbjct: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKDEPINCESFKVTLMA 2153
Query: 1077 TVELAT-----YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC 1131
++ F L EVR FQ WP+ P T L + + +
Sbjct: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAA 2213
Query: 1132 NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQ 1191
N GPM+VH G G F + ++ +++ E +VD+Y ++ R + +Q
Sbjct: 2214 NRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQ 2271
Query: 1192 YIFIHDALLEAVTCGNTEVPARNL 1215
Y F++ +L V+ E P+ +L
Sbjct: 2272 YQFLYKVILSLVSTRQEENPSTSL 2295
Score = 35.0 bits (79), Expect = 0.55
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 7/83 (8%)
Query: 515 QPLNFKAEPESETSILLSWTPPR---SDTIANYELVYK--DGEHGEEQRITIE--PGTSY 567
+P N +A+PE+ TS+L++W PR I + ++Y+ DGE + +
Sbjct: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGA 373
Query: 568 RLQGLKPNSLYYFRLAARSPQGL 590
L L PN Y ++ A GL
Sbjct: 374 ILNNLLPNMSYVLQIVAICTNGL 396
Score = 31.6 bits (70), Expect = 6.0
Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 8/91 (8%)
Query: 411 EQAPSSAPRDVQARMLSSTTILVQWKEPEEP-NGQIQGYRVYYTM----DPTQHVNNWMK 465
E SS P +VQA + T++LV W+ P + I+ + V Y D T+H ++
Sbjct: 308 EAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKH--EFLT 365
Query: 466 HNVADSQITTIGNLVPQKTYSVKVLAFTSIG 496
D + NL+P +Y ++++A + G
Sbjct: 366 DGYQDLG-AILNNLLPNMSYVLQIVAICTNG 395
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
precursor [Homo sapiens]
Length = 1256
Score = 396 bits (1018), Expect = e-110
Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)
Query: 926 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 984
PI L + +R A++ F E++SI +F + + N+ KNRY +++ YD+
Sbjct: 582 PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 641
Query: 985 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1044
+RV LS I G GS+Y+NA+YIDG+++ YIA QG ET DFWRMIWEQ++ +VM+
Sbjct: 642 NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 701
Query: 1045 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1101
T+ EE +R KC +YWPS GT G V V + Y ++ + K + REV
Sbjct: 702 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 761
Query: 1102 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1161
QFT+WPDHGVPE P L RRV + +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 762 THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 821
Query: 1162 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1221
++ E VD+YG+V +R QR MVQ E QYI IH AL+E G TEV L+ Y+
Sbjct: 822 GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 881
Query: 1222 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1279
+ + + + +E EF+RL S ++ ++ I N NK KNR N++PY+ RV L+
Sbjct: 882 MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 940
Query: 1280 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1322
E S YINASFI Y + + IA QGPL ET DFW+M+
Sbjct: 941 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1000
Query: 1323 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1382
++ ++VMLT+L+ +E C QYW E Y VD Y LR F++ +
Sbjct: 1001 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1059
Query: 1383 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1434
+ SRTV Q+Q+T+W + +P + I I V K ++ +G P+ +HC
Sbjct: 1060 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1119
Query: 1435 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1487
G +TG+F L +LE E VVDIFQ VK LR RP MV T +QYQF Y
Sbjct: 1120 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172
Score = 197 bits (501), Expect = 6e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 1254 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1313
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 622 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681
Query: 1314 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1371
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 682 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741
Query: 1372 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1430
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 742 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799
Query: 1431 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1490
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E QY ++A
Sbjct: 800 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
Query: 1491 LEY 1493
+EY
Sbjct: 860 VEY 862
Score = 156 bits (395), Expect = 1e-37
Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)
Query: 927 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 981
+ + EL ++ +K D E++ + + + +H N E NK KNR +NVI
Sbjct: 870 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 929
Query: 982 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1022
YD++RV L S + SD Y+NA++I Y K IA QG L
Sbjct: 930 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 989
Query: 1023 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1082
ET GDFW+MI++++ +VM+T+L+ + C QYW G +T+G ++V L DT + +T
Sbjct: 990 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 1048
Query: 1083 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1135
Y +R F L + + R V Q+Q+T W +P P ++ ++ VK P
Sbjct: 1049 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 1108
Query: 1136 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1192
+ P+++HC G +TG F + +LE + E+ VDI+ V +R R MV T +QY
Sbjct: 1109 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1168
Query: 1193 IFIHDALLEAVTCGNTEVPARN 1214
F++D + N +V N
Sbjct: 1169 QFLYDVIASTYPAQNGQVKKNN 1190
Score = 34.3 bits (77), Expect = 0.93
Identities = 39/161 (24%), Positives = 69/161 (42%), Gaps = 19/161 (11%)
Query: 427 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 484
+ TTI ++WK E +T D TQ++ + + + D++ + NL P+
Sbjct: 267 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 314
Query: 485 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 544
Y + +S I + T G PG+P E+ +++W PP+ + N+
Sbjct: 315 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 372
Query: 545 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAA 584
L Y + E+ + ++ Y LQ LKP + Y L A
Sbjct: 373 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHA 411
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
precursor [Homo sapiens]
Length = 1304
Score = 396 bits (1018), Expect = e-110
Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)
Query: 926 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 984
PI L + +R A++ F E++SI +F + + N+ KNRY +++ YD+
Sbjct: 630 PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 689
Query: 985 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1044
+RV LS I G GS+Y+NA+YIDG+++ YIA QG ET DFWRMIWEQ++ +VM+
Sbjct: 690 NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 749
Query: 1045 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1101
T+ EE +R KC +YWPS GT G V V + Y ++ + K + REV
Sbjct: 750 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 809
Query: 1102 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1161
QFT+WPDHGVPE P L RRV + +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 810 THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 869
Query: 1162 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1221
++ E VD+YG+V +R QR MVQ E QYI IH AL+E G TEV L+ Y+
Sbjct: 870 GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 929
Query: 1222 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1279
+ + + + +E EF+RL S ++ ++ I N NK KNR N++PY+ RV L+
Sbjct: 930 MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 988
Query: 1280 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1322
E S YINASFI Y + + IA QGPL ET DFW+M+
Sbjct: 989 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1048
Query: 1323 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1382
++ ++VMLT+L+ +E C QYW E Y VD Y LR F++ +
Sbjct: 1049 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1107
Query: 1383 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1434
+ SRTV Q+Q+T+W + +P + I I V K ++ +G P+ +HC
Sbjct: 1108 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1167
Query: 1435 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1487
G +TG+F L +LE E VVDIFQ VK LR RP MV T +QYQF Y
Sbjct: 1168 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1220
Score = 197 bits (501), Expect = 6e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 1254 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1313
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 670 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 729
Query: 1314 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1371
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 730 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 789
Query: 1372 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1430
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 790 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 847
Query: 1431 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1490
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E QY ++A
Sbjct: 848 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907
Query: 1491 LEY 1493
+EY
Sbjct: 908 VEY 910
Score = 156 bits (395), Expect = 1e-37
Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)
Query: 927 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 981
+ + EL ++ +K D E++ + + + +H N E NK KNR +NVI
Sbjct: 918 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 977
Query: 982 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1022
YD++RV L S + SD Y+NA++I Y K IA QG L
Sbjct: 978 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 1037
Query: 1023 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1082
ET GDFW+MI++++ +VM+T+L+ + C QYW G +T+G ++V L DT + +T
Sbjct: 1038 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 1096
Query: 1083 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1135
Y +R F L + + R V Q+Q+T W +P P ++ ++ VK P
Sbjct: 1097 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 1156
Query: 1136 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1192
+ P+++HC G +TG F + +LE + E+ VDI+ V +R R MV T +QY
Sbjct: 1157 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1216
Query: 1193 IFIHDALLEAVTCGNTEVPARN 1214
F++D + N +V N
Sbjct: 1217 QFLYDVIASTYPAQNGQVKKNN 1238
Score = 34.3 bits (77), Expect = 0.93
Identities = 39/161 (24%), Positives = 69/161 (42%), Gaps = 19/161 (11%)
Query: 427 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 484
+ TTI ++WK E +T D TQ++ + + + D++ + NL P+
Sbjct: 315 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 362
Query: 485 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 544
Y + +S I + T G PG+P E+ +++W PP+ + N+
Sbjct: 363 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 420
Query: 545 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAA 584
L Y + E+ + ++ Y LQ LKP + Y L A
Sbjct: 421 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHA 459
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
precursor [Homo sapiens]
Length = 1143
Score = 396 bits (1018), Expect = e-110
Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)
Query: 926 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 984
PI L + +R A++ F E++SI +F + + N+ KNRY +++ YD+
Sbjct: 469 PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 528
Query: 985 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1044
+RV LS I G GS+Y+NA+YIDG+++ YIA QG ET DFWRMIWEQ++ +VM+
Sbjct: 529 NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 588
Query: 1045 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1101
T+ EE +R KC +YWPS GT G V V + Y ++ + K + REV
Sbjct: 589 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 648
Query: 1102 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1161
QFT+WPDHGVPE P L RRV + +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 649 THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 708
Query: 1162 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1221
++ E VD+YG+V +R QR MVQ E QYI IH AL+E G TEV L+ Y+
Sbjct: 709 GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 768
Query: 1222 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1279
+ + + + +E EF+RL S ++ ++ I N NK KNR N++PY+ RV L+
Sbjct: 769 MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 827
Query: 1280 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1322
E S YINASFI Y + + IA QGPL ET DFW+M+
Sbjct: 828 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 887
Query: 1323 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1382
++ ++VMLT+L+ +E C QYW E Y VD Y LR F++ +
Sbjct: 888 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 946
Query: 1383 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1434
+ SRTV Q+Q+T+W + +P + I I V K ++ +G P+ +HC
Sbjct: 947 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1006
Query: 1435 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1487
G +TG+F L +LE E VVDIFQ VK LR RP MV T +QYQF Y
Sbjct: 1007 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059
Score = 197 bits (501), Expect = 6e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 1254 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1313
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568
Query: 1314 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1371
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 569 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628
Query: 1372 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1430
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 629 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686
Query: 1431 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1490
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E QY ++A
Sbjct: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
Query: 1491 LEY 1493
+EY
Sbjct: 747 VEY 749
Score = 156 bits (395), Expect = 1e-37
Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)
Query: 927 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 981
+ + EL ++ +K D E++ + + + +H N E NK KNR +NVI
Sbjct: 757 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 816
Query: 982 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1022
YD++RV L S + SD Y+NA++I Y K IA QG L
Sbjct: 817 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 876
Query: 1023 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1082
ET GDFW+MI++++ +VM+T+L+ + C QYW G +T+G ++V L DT + +T
Sbjct: 877 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 935
Query: 1083 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1135
Y +R F L + + R V Q+Q+T W +P P ++ ++ VK P
Sbjct: 936 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 995
Query: 1136 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1192
+ P+++HC G +TG F + +LE + E+ VDI+ V +R R MV T +QY
Sbjct: 996 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1055
Query: 1193 IFIHDALLEAVTCGNTEVPARN 1214
F++D + N +V N
Sbjct: 1056 QFLYDVIASTYPAQNGQVKKNN 1077
Score = 34.3 bits (77), Expect = 0.93
Identities = 39/161 (24%), Positives = 69/161 (42%), Gaps = 19/161 (11%)
Query: 427 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 484
+ TTI ++WK E +T D TQ++ + + + D++ + NL P+
Sbjct: 154 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 201
Query: 485 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 544
Y + +S I + T G PG+P E+ +++W PP+ + N+
Sbjct: 202 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 259
Query: 545 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAA 584
L Y + E+ + ++ Y LQ LKP + Y L A
Sbjct: 260 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHA 298
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,853,770
Number of Sequences: 37866
Number of extensions: 2844887
Number of successful extensions: 15931
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 299
Number of HSP's successfully gapped in prelim test: 220
Number of HSP's that attempted gapping in prelim test: 6758
Number of HSP's gapped (non-prelim): 3437
length of query: 1502
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1387
effective length of database: 13,892,928
effective search space: 19269491136
effective search space used: 19269491136
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.