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Search of human proteins with 102469034
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|102469034 janus kinase 1 [Homo sapiens]
(1154 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|102469034 janus kinase 1 [Homo sapiens] 2370 0.0
gi|187608615 tyrosine kinase 2 [Homo sapiens] 990 0.0
gi|4826776 Janus kinase 2 [Homo sapiens] 908 0.0
gi|47157315 Janus kinase 3 [Homo sapiens] 765 0.0
gi|4503787 fyn-related kinase [Homo sapiens] 184 5e-46
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 179 1e-44
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 179 1e-44
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 172 1e-42
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 172 1e-42
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 172 1e-42
gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sap... 172 2e-42
gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sap... 172 2e-42
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 171 3e-42
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 171 3e-42
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 171 3e-42
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 171 3e-42
gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2... 169 1e-41
gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1... 169 1e-41
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 169 1e-41
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 167 5e-41
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 167 5e-41
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 167 5e-41
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 167 5e-41
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 167 5e-41
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 167 5e-41
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 167 5e-41
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 167 5e-41
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 167 5e-41
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 166 9e-41
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 166 9e-41
>gi|102469034 janus kinase 1 [Homo sapiens]
Length = 1154
Score = 2370 bits (6143), Expect = 0.0
Identities = 1154/1154 (100%), Positives = 1154/1154 (100%)
Query: 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEEL 60
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEEL
Sbjct: 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEEL 60
Query: 61 CIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN 120
CIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN
Sbjct: 61 CIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN 120
Query: 121 DNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ 180
DNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
Sbjct: 121 DNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ 180
Query: 181 DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI 240
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
Sbjct: 181 DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI 240
Query: 241 NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN 300
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
Sbjct: 241 NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN 300
Query: 301 WFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIR 360
WFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIR
Sbjct: 301 WFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIR 360
Query: 361 EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH 420
EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH
Sbjct: 361 EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH 420
Query: 421 HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT 480
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
Sbjct: 421 HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT 480
Query: 481 CFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFML 540
CFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFML
Sbjct: 481 CFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFML 540
Query: 541 KRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSG 600
KRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSG
Sbjct: 541 KRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSG 600
Query: 601 TLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD 660
TLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD
Sbjct: 601 TLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD 660
Query: 661 VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL 720
VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL
Sbjct: 661 VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL 720
Query: 721 LLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG 780
LLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG
Sbjct: 721 LLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG 780
Query: 781 TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRA 840
TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRA
Sbjct: 781 TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRA 840
Query: 841 IMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN 900
IMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN
Sbjct: 841 IMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN 900
Query: 901 TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP 960
TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP
Sbjct: 901 TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP 960
Query: 961 SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG 1020
SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG
Sbjct: 961 SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG 1020
Query: 1021 DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDS 1080
DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDS
Sbjct: 1021 DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDS 1080
Query: 1081 DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRT 1140
DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRT
Sbjct: 1081 DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRT 1140
Query: 1141 SFQNLIEGFEALLK 1154
SFQNLIEGFEALLK
Sbjct: 1141 SFQNLIEGFEALLK 1154
>gi|187608615 tyrosine kinase 2 [Homo sapiens]
Length = 1187
Score = 990 bits (2560), Expect = 0.0
Identities = 530/1130 (46%), Positives = 725/1130 (64%), Gaps = 54/1130 (4%)
Query: 56 TAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTN 115
TAEE+CI A I+P C NLFAL+D ++W PN + + SL L++R+RFYF N
Sbjct: 52 TAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRN 111
Query: 116 WHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRD 175
WHG N E +V+R P + ++ LLD +S EYLF QG+++ V +A + +
Sbjct: 112 WHGMNPREPAVYRCGPPGTEASSDQTA--QGMQLLDPASFEYLFEQGKHEFVNDVASLWE 169
Query: 176 PKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLL 235
TE++ H +NE LGMA L + H A+ + L E+ K S+K IP + + IRQ + L
Sbjct: 170 LSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSAL 229
Query: 236 TRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISS 295
TR+R+ NVF+ FL++F +S + VKYLATLE L +G E L + +
Sbjct: 230 TRLRLRNVFRRFLRDFQ-----PGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLA 284
Query: 296 ENEMNWFHSNDGG------------NVLYYEVMVTGNLGIQWRHKPNVVSVEKEKN---- 339
+ E + D G +EV+VTG GIQW V+ E+ +
Sbjct: 285 QAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSG 344
Query: 340 -----KLKRKKLENKHKKDEEKNKIREE-WNNFSYFPEITHIVIKESVVSINKQDNKKME 393
L KK + + ++ RE W F F +ITH+V+KE VSI++QDNK +E
Sbjct: 345 RNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLE 404
Query: 394 LKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKL 453
L L S ALSFVSLVDGYFRLTAD+ HYLC +VAPP +V +I++G HGP+ + KL
Sbjct: 405 LSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKL 464
Query: 454 RQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQK-QFKNFQIEVQKGRYSLHGS 512
R E +G+Y++ WS + +++TV ++S+ G Q + + F IE Q G + L G
Sbjct: 465 RPE---DGLYLIHWSTSHPYRLILTVA--QRSQAPDGMQSLRLRKFPIEQQDGAFVLEGW 519
Query: 513 DRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQ 572
RSFPS+ +L + L+ +LR + F L+RCC P+P E SNL++ + A+ +SQ
Sbjct: 520 GRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIM-RGARASPRTLNLSQ 578
Query: 573 LSFDRILKKDLVQGEHLGRGTRTHIYSGTL------------MDYKDD--EGTSEEKKIK 618
LSF R+ +K++ Q HLG+GTRT++Y G L MD +D G ++++
Sbjct: 579 LSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELR 638
Query: 619 VILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLF 678
V+LKVLDPSH DI+LAF+E AS+M QVSH H+ +++GVCVR ENIMV E+VE GPLD++
Sbjct: 639 VVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVW 698
Query: 679 MHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLS 738
+ R+ + WK VA+QLASALSYLE+K+LVHGNVC +N+LLAR G+ PFIKLS
Sbjct: 699 LRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLS 758
Query: 739 DPGIPITVLSRQECIERIPWIAPECVEDSKN-LSVAADKWSFGTTLWEICYNGEIPLKDK 797
DPG+ + LSR+E +ERIPW+APEC+ N LS A DKW FG TL EIC++GE PL+ +
Sbjct: 759 DPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSR 818
Query: 798 TLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQN-PDIV 856
+ EKE FY+ + R PSC +LA L ++C+ Y+P QRP FR I+RD+ +L+ N D++
Sbjct: 819 SPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVL 878
Query: 857 SEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGG 916
+ + DPT F KR+LK+IRDLGEGHFGKV L YDP D TGE VAVK+LK + G
Sbjct: 879 TVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGP 938
Query: 917 NHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKIN 976
H + K+EI+ILR LYHE+I+KYKG C + G ++L+ME++P GSL++YLP++ I
Sbjct: 939 QHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS--IG 996
Query: 977 LKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYT 1036
L Q L +A QIC+GM YL ++ Y+HRDLAARNVL++++ VKIGDFGL KA+ EYY
Sbjct: 997 LAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYR 1056
Query: 1037 VKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTH 1096
V++D DSPVFWYAPECL + KFY ASDVWSFGVTL+ELLT+CDS SP FL++IG
Sbjct: 1057 VREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQ 1116
Query: 1097 GQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLI 1146
GQMTV RL L+ G+RLP P CP EVY LM+ CWE + S R +F+NLI
Sbjct: 1117 GQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLI 1166
Score = 66.2 bits (160), Expect = 2e-10
Identities = 66/289 (22%), Positives = 126/289 (43%), Gaps = 41/289 (14%)
Query: 877 RIRDLGEGHFGKVELCRYDP--EGDNTGEQ--VAVKSLKPESGGNHIADLKKEIEILRNL 932
R+ G+ GK++ DP G + G++ V +K L P +A + ++ +
Sbjct: 609 RVEGSGDPEEGKMD--DEDPLVPGRDRGQELRVVLKVLDPSHHDIALA-FYETASLMSQV 665
Query: 933 YHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMD 992
H ++ G+C N ++ E++ G L +L + + + + ++ A Q+ +
Sbjct: 666 SHTHLAFVHGVCVRGPEN--IMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALS 723
Query: 993 YLGSRQYVHRDLAARNVLVE-------SEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPV 1045
YL ++ VH ++ RN+L+ + +K+ D G+ + +++R +
Sbjct: 724 YLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALS-------REERVERI 776
Query: 1046 FWYAPECLM--QSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTR 1103
W APECL + A D W FG TL E+ C +P L+ P+ + R
Sbjct: 777 PWLAPECLPGGANSLSTAMDKWGFGATLLEI---CFDGEAP----LQSRSPSEKEHFYQR 829
Query: 1104 LVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL 1152
RLP P+CP ++ L +C ++P+ R SF+ ++ L
Sbjct: 830 Q-------HRLP-EPSCP-QLATLTSQCLTYEPTQRPSFRTILRDLTRL 869
>gi|4826776 Janus kinase 2 [Homo sapiens]
Length = 1132
Score = 908 bits (2347), Expect = 0.0
Identities = 502/1151 (43%), Positives = 704/1151 (61%), Gaps = 105/1151 (9%)
Query: 33 EPGVEVIFY----LSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLW 88
+P ++V Y S+ + L SGEY AEE+CI A++AC I+P+ HN+FAL E ++W
Sbjct: 36 DPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIW 95
Query: 89 YAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATP 148
Y PN +D+ + YR+RFYF W+ + N +RH + G E P
Sbjct: 96 YPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNR--AYRHGISR---GAE-------AP 143
Query: 149 LLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQL 208
LLD + YLFAQ ++D V I+ P T H+ + ECLGMAVL + A
Sbjct: 144 LLDDFVMSYLFAQWRHDFVH--GWIKVPVT----HETQEECLGMAVLDMMRIAKENDQTP 197
Query: 209 PELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKV 268
+ ISYK ++P+ + I+ ++LTR RI F+ F+++F+ + +LK+
Sbjct: 198 LAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQ-----CKATARNLKL 252
Query: 269 KYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHK 328
KYL LETL + E FE S G ++ +++TGN GIQW
Sbjct: 253 KYLINLETLQSAFYTEKFEVKEP-----------GSGPSGEEIFATIIITGNGGIQWSR- 300
Query: 329 PNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKES-------- 380
KHK+ E + ++ + FP I + IK++
Sbjct: 301 -------------------GKHKESETLTE--QDLQLYCDFPNIIDVSIKQANQEGSNES 339
Query: 381 -VVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNG 439
VV+I+KQD K +E++LSS EALSFVSL+DGY+RLTADAHHYLC +VAPP ++ NIQ+
Sbjct: 340 RVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSN 399
Query: 440 CHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQ 499
CHGPI ++AI+KL++ G++ G+YVLR S DF+ +T E+ ++ +K+
Sbjct: 400 CHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAV-ERENVIE-----YKHCL 453
Query: 500 IEVQKGR-YSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVAT 558
I + Y+L G+ ++F SL DL++ + + +R+DNI F +CC PKP++ SNLLV
Sbjct: 454 ITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFR 513
Query: 559 KKAQEWQPVYP-------MSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGT 611
P P M+Q+ F +I +DL+ E LG+GT T I+ G + D
Sbjct: 514 TNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGD---Y 570
Query: 612 SEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVE 671
+ + +V+LKVLD +HR+ S +FFEAASMM ++SHKH+V YGVCV ENI+V+EFV+
Sbjct: 571 GQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK 630
Query: 672 GGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSEC 731
G LD ++ + + + WK +VAKQLA A+ +LE+ L+HGNVC KN+LL RE D +
Sbjct: 631 FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREE-DRKT 689
Query: 732 G--PFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYN 789
G PFIKLSDPGI ITVL + ERIPW+ PEC+E+ KNL++A DKWSFGTTLWEIC
Sbjct: 690 GNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSG 749
Query: 790 GEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLE 849
G+ PL K +FYE R + P ELA+L+ CM+Y+P+ RP FRAI+RD+N L
Sbjct: 750 GDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLF 809
Query: 850 EQNPDIVSEKKPATEV--------------DPTHFEKRFLKRIRDLGEGHFGKVELCRYD 895
+ ++++E + DPT FE+R LK ++ LG+G+FG VE+CRYD
Sbjct: 810 TPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYD 869
Query: 896 PEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLI 955
P DNTGE VAVK L+ S H+ D ++EIEIL++L H+NIVKYKG+C G +KLI
Sbjct: 870 PLQDNTGEVVAVKKLQ-HSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLI 928
Query: 956 MEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEH 1015
ME+LP GSL++YL K+K +I+ + L+Y QICKGM+YLG+++Y+HRDLA RN+LVE+E+
Sbjct: 929 MEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENEN 988
Query: 1016 QVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELL 1075
+VKIGDFGLTK + DKEYY VK+ +SP+FWYAPE L +SKF +ASDVWSFGV L+EL
Sbjct: 989 RVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELF 1048
Query: 1076 TYCDSDSSPMALFLKMIG-PTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEF 1134
TY + SP A F++MIG GQM V L+ LK RLP P CPDE+Y +M +CW
Sbjct: 1049 TYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNN 1108
Query: 1135 QPSNRTSFQNL 1145
+ R SF++L
Sbjct: 1109 NVNQRPSFRDL 1119
Score = 96.3 bits (238), Expect = 2e-19
Identities = 78/298 (26%), Positives = 132/298 (44%), Gaps = 30/298 (10%)
Query: 867 PTHFEKRFLKRIRD--------LGEGHFGKVELCRYDPEGD--NTGEQVAVKSLKPESGG 916
PTH + +IR+ LG+G F K+ GD E + + ++
Sbjct: 529 PTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHR 588
Query: 917 NHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKIN 976
N+ + ++ L H+++V G+C G+ L+ EF+ GSL YL KNKN IN
Sbjct: 589 NYSESFFEAASMMSKLSHKHLVLNYGVCV--CGDENILVQEFVKFGSLDTYLKKNKNCIN 646
Query: 977 LKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYT 1036
+ +L+ A Q+ M +L +H ++ A+N+L+ E K G+ K +
Sbjct: 647 ILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITV 706
Query: 1037 V-KDDRDSPVFWYAPECLMQSK-FYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGP 1094
+ KD + W PEC+ K +A+D WSFG TL E+ C P++
Sbjct: 707 LPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEI---CSGGDKPLSA------- 756
Query: 1095 THGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL 1152
+ R + ++ +LP P E+ L+ C +++P R SF+ +I +L
Sbjct: 757 ----LDSQRKLQFYEDRHQLPAPKWA--ELANLINNCMDYEPDFRPSFRAIIRDLNSL 808
>gi|47157315 Janus kinase 3 [Homo sapiens]
Length = 1124
Score = 765 bits (1975), Expect = 0.0
Identities = 450/1131 (39%), Positives = 634/1131 (56%), Gaps = 113/1131 (9%)
Query: 48 LRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHY 107
L G++ AE+LC++AA+A I P+ H+LFAL E+ W+ P+ +V+D + L Y
Sbjct: 41 LSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLY 100
Query: 108 RMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLV 167
R+RFYF NW G K + G K A+ +LD LE+LFAQ + DLV
Sbjct: 101 RIRFYFPNWFGLE-----------KCHRFGLRKDL---ASAILDLPVLEHLFAQHRSDLV 146
Query: 168 KCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNK 227
P+ EQ ECL +AVL ++ A + + EL K +SYK +P +L
Sbjct: 147 SGRLPVGLSLKEQ------GECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRD 200
Query: 228 SIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFE 287
I+ + +TR RI + L+ + H L KY+ LE L AE F
Sbjct: 201 LIQGLSFVTRRRIRRTVRRALRR-----VAACQADRHSLMAKYIMDLERLDPAGAAETFH 255
Query: 288 TSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLE 347
+ +DG +L V G+ GI W
Sbjct: 256 VGL--------PGALGGHDGLGLL----RVAGDGGIAWTQGE------------------ 285
Query: 348 NKHKKDEEKNKIREEWNNFSYFPEITHIVIKES----------VVSINKQDNKKMELKLS 397
+E F FPEI I IK++ +V++ + DN+ +E +
Sbjct: 286 ------------QEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFP 333
Query: 398 SHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEG 457
EALSFV+LVDGYFRLT D+ H+ C +VAPP ++ + CHGPI ++AINKL+ G
Sbjct: 334 GLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGG 393
Query: 458 SEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQK-GRYSLHGSDRSF 516
S G YVLR S DFD+ L+TV C + +K I G + L G R
Sbjct: 394 SRPGSYVLRRSPQDFDSFLLTV-CVQNP-----LGPDYKGCLIRRSPTGTFLLVGLSRPH 447
Query: 517 PSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVA-------TKKAQEWQPVYP 569
SL +L++ L D ++ L CC P+P+E SNL+V T + Q Y
Sbjct: 448 SSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQ 507
Query: 570 MSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHR 629
+SQ++F +I L E+LG G+ T IY G + D E +K +V+LKV+D H+
Sbjct: 508 LSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEA----RKTEVLLKVMDAKHK 563
Query: 630 DISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTP 689
+ +F EAAS+M QVS++H+V L+GVC+ ++ MV+EFV G +D+++ ++ ++
Sbjct: 564 NCMESFLEAASLMSQVSYRHLVLLHGVCMAG-DSTMVQEFVHLGAIDMYLRKRGHLVPAS 622
Query: 690 WKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSR 749
WK +V KQLA AL+YLEDK L HGNV + +LLAREG D PFIKLSDPG+ VLS
Sbjct: 623 WKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGS-PPFIKLSDPGVSPAVLSL 681
Query: 750 QECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESR 809
+ +RIPW+APEC+ +++ LS+ ADKW FG T+WE+ +P+ +K +FYE R
Sbjct: 682 EMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDR 741
Query: 810 CRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEV---- 865
+ P ELA L+ +CM Y+P QRP FRA++RD+N L + +++S+ P
Sbjct: 742 QQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDG 801
Query: 866 -----------DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPES 914
DPT FE+R LK I LG+G+FG VELCRYDP GDNTG VAVK L+ S
Sbjct: 802 LWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HS 860
Query: 915 GGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNK 974
G + D ++EI+IL+ L+ + IVKY+G+ G ++L+ME+LPSG L+++L +++ +
Sbjct: 861 GPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR 920
Query: 975 INLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEY 1034
++ + L Y+ QICKGM+YLGSR+ VHRDLAARN+LVESE VKI DFGL K + DK+Y
Sbjct: 921 LDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDY 980
Query: 1035 YTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGP 1094
Y V++ SP+FWYAPE L + F SDVWSFGV L+EL TYCD SP A FL+M+G
Sbjct: 981 YVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGC 1040
Query: 1095 THGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNL 1145
+ RL+ L+EG+RLP PP CP EV++LM+ CW P +R SF L
Sbjct: 1041 ERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSAL 1091
Score = 69.7 bits (169), Expect = 2e-11
Identities = 62/283 (21%), Positives = 133/283 (46%), Gaps = 36/283 (12%)
Query: 880 DLGEGHFGKVEL-CRYDP-EGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENI 937
+LG G F K+ CR++ +G+ +V +K + + N + + ++ + + ++
Sbjct: 526 NLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHK-NCMESFLEAASLMSQVSYRHL 584
Query: 938 VKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSR 997
V G+C ++ EF+ G++ YL K + + +L+ Q+ ++YL +
Sbjct: 585 VLLHGVCMAGDST---MVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDK 641
Query: 998 QYVHRDLAARNVLVESEHQ------VKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPE 1051
H +++AR VL+ E +K+ D G++ A+ + + DR + W APE
Sbjct: 642 GLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLS----LEMLTDR---IPWVAPE 694
Query: 1052 CLMQSK-FYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKE 1110
CL +++ + +D W FG T+ E+ S + + + + P + + ++
Sbjct: 695 CLREAQTLSLEADKWGFGATVWEVF-------SGVTMPISALDPA-------KKLQFYED 740
Query: 1111 GKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
++LP P E+ L+++C ++P R SF+ +I +L+
Sbjct: 741 RQQLPAPKWT--ELALLIQQCMAYEPVQRPSFRAVIRDLNSLI 781
Score = 55.5 bits (132), Expect = 3e-07
Identities = 53/207 (25%), Positives = 88/207 (42%), Gaps = 31/207 (14%)
Query: 665 MVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAR 724
+V E++ G L F+ R L + Q+ + YL + VH ++ +N+L+
Sbjct: 900 LVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVES 959
Query: 725 EGIDSECGPFIKLSDPGIP-ITVLSRQECIERIP------WIAPECVEDSKNLSVAADKW 777
E +K++D G+ + L + + R P W APE + D+ S +D W
Sbjct: 960 EA-------HVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNI-FSRQSDVW 1011
Query: 778 SFGTTLWEI---CYNGEIPLKD-KTLIEKERFYESRCR-----------PVTPSCK-ELA 821
SFG L+E+ C P + ++ ER + CR P P+C E+
Sbjct: 1012 SFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVH 1071
Query: 822 DLMTRCMNYDPNQRPFFRAIMRDINKL 848
+LM C P RP F A+ ++ L
Sbjct: 1072 ELMKLCWAPSPQDRPSFSALGPQLDML 1098
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 184 bits (466), Expect = 5e-46
Identities = 108/283 (38%), Positives = 161/283 (56%), Gaps = 25/283 (8%)
Query: 865 VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKK 924
VD ++ ++ ++ LG G FG+V ++ +NT VAVK+LKP G D +
Sbjct: 224 VDQWEIDRNSIQLLKRLGSGQFGEV----WEGLWNNT-TPVAVKTLKP--GSMDPNDFLR 276
Query: 925 EIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK-NKINLKQQLKY 983
E +I++NL H +++ +CT + + I +I E + GSL+EYL + +KI+L QQ+
Sbjct: 277 EAQIMKNLRHPKLIQLYAVCTLE--DPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDM 334
Query: 984 AVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKE-YYTVKDDRD 1042
A Q+ GM YL SR Y+HRDLAARNVLV + K+ DFGL + + D E Y + +
Sbjct: 335 AAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIK 394
Query: 1043 SPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT 1102
PV W APE + +KF I SDVWSFG+ L+E++TY KM + MT
Sbjct: 395 LPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYG-----------KM---PYSGMTGA 440
Query: 1103 RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNL 1145
+++ L + RLP P NCP + Y +M +CW +P R +F+ L
Sbjct: 441 QVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETL 483
Score = 88.2 bits (217), Expect = 4e-17
Identities = 61/230 (26%), Positives = 108/230 (46%), Gaps = 12/230 (5%)
Query: 619 VILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLF 678
V +K L P D + F A +M+ + H ++ LY VC + ++ E + G L +
Sbjct: 259 VAVKTLKPGSMDPN-DFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEY 317
Query: 679 MHRKS-DVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGI----DSECGP 733
+ + + + +A Q+AS ++YLE ++ +H ++ +N+L+ I D
Sbjct: 318 LQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLAR 377
Query: 734 FIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIP 793
K+ + I SR E + W APE + +K S+ +D WSFG L+EI G++P
Sbjct: 378 VFKVDNEDI---YESRHEIKLPVKWTAPEAIRSNK-FSIKSDVWSFGILLYEIITYGKMP 433
Query: 794 LKDKTLIEKERFYESRCRPVTPS-C-KELADLMTRCMNYDPNQRPFFRAI 841
T + + R PS C ++ ++M C N +P +RP F +
Sbjct: 434 YSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETL 483
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 179 bits (454), Expect = 1e-44
Identities = 103/280 (36%), Positives = 153/280 (54%), Gaps = 18/280 (6%)
Query: 875 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYH 934
LKR++ LG G FG V + PEG+ VA+K L +G + E I+ ++ H
Sbjct: 718 LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH 777
Query: 935 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYL 994
++V+ G+C I+L+ + +P G L EY+ ++K+ I + L + VQI KGM YL
Sbjct: 778 PHLVRLLGVCLSPT---IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYL 834
Query: 995 GSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLM 1054
R+ VHRDLAARNVLV+S + VKI DFGL + +E D++ Y D P+ W A EC+
Sbjct: 835 EERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNA-DGGKMPIKWMALECIH 893
Query: 1055 QSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRL 1114
KF SDVWS+GVT+ EL+T+ G + + + + L++G+RL
Sbjct: 894 YRKFTHQSDVWSYGVTIWELMTFG--------------GKPYDGIPTREIPDLLEKGERL 939
Query: 1115 PCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 1154
P PP C +VY +M KCW +R F+ L F + +
Sbjct: 940 PQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMAR 979
Score = 82.8 bits (203), Expect = 2e-15
Identities = 76/289 (26%), Positives = 139/289 (48%), Gaps = 39/289 (13%)
Query: 577 RILKK-DLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVL-DPSHRDISLA 634
RILK+ +L + + LG G +Y G + EG E KI V +K+L + + ++
Sbjct: 711 RILKETELKRVKVLGSGAFGTVYKGIWVP----EG--ETVKIPVAIKILNETTGPKANVE 764
Query: 635 FFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKV 694
F + A +M + H H+V L GVC+ ++ + G L+ ++H D + +
Sbjct: 765 FMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLE-YVHEHKDNIGSQLLLNW 823
Query: 695 AKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIE 754
Q+A + YLE++ LVH ++ +N+L+ +K++D G+ + ++
Sbjct: 824 CVQIAKGMMYLEERRLVHRDLAARNVLVKSPN-------HVKITDFGLARLLEGDEKEYN 876
Query: 755 R------IPWIAPECVEDSKNLSVAADKWSFGTTLWEIC------YNGEIPLKD-KTLIE 801
I W+A EC+ K + +D WS+G T+WE+ Y+G IP ++ L+E
Sbjct: 877 ADGGKMPIKWMALECIHYRK-FTHQSDVWSYGVTIWELMTFGGKPYDG-IPTREIPDLLE 934
Query: 802 K-ERFYESRCRPVTPSCK-ELADLMTRCMNYDPNQRPFFRAIMRDINKL 848
K ER P P C ++ +M +C D + RP F+ + + +++
Sbjct: 935 KGERL------PQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRM 977
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 179 bits (454), Expect = 1e-44
Identities = 103/280 (36%), Positives = 153/280 (54%), Gaps = 18/280 (6%)
Query: 875 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYH 934
LKR++ LG G FG V + PEG+ VA+K L +G + E I+ ++ H
Sbjct: 718 LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH 777
Query: 935 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYL 994
++V+ G+C I+L+ + +P G L EY+ ++K+ I + L + VQI KGM YL
Sbjct: 778 PHLVRLLGVCLSPT---IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYL 834
Query: 995 GSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLM 1054
R+ VHRDLAARNVLV+S + VKI DFGL + +E D++ Y D P+ W A EC+
Sbjct: 835 EERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNA-DGGKMPIKWMALECIH 893
Query: 1055 QSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRL 1114
KF SDVWS+GVT+ EL+T+ G + + + + L++G+RL
Sbjct: 894 YRKFTHQSDVWSYGVTIWELMTFG--------------GKPYDGIPTREIPDLLEKGERL 939
Query: 1115 PCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 1154
P PP C +VY +M KCW +R F+ L F + +
Sbjct: 940 PQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMAR 979
Score = 82.8 bits (203), Expect = 2e-15
Identities = 76/289 (26%), Positives = 139/289 (48%), Gaps = 39/289 (13%)
Query: 577 RILKK-DLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVL-DPSHRDISLA 634
RILK+ +L + + LG G +Y G + EG E KI V +K+L + + ++
Sbjct: 711 RILKETELKRVKVLGSGAFGTVYKGIWVP----EG--ETVKIPVAIKILNETTGPKANVE 764
Query: 635 FFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKV 694
F + A +M + H H+V L GVC+ ++ + G L+ ++H D + +
Sbjct: 765 FMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLE-YVHEHKDNIGSQLLLNW 823
Query: 695 AKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIE 754
Q+A + YLE++ LVH ++ +N+L+ +K++D G+ + ++
Sbjct: 824 CVQIAKGMMYLEERRLVHRDLAARNVLVKSPN-------HVKITDFGLARLLEGDEKEYN 876
Query: 755 R------IPWIAPECVEDSKNLSVAADKWSFGTTLWEIC------YNGEIPLKD-KTLIE 801
I W+A EC+ K + +D WS+G T+WE+ Y+G IP ++ L+E
Sbjct: 877 ADGGKMPIKWMALECIHYRK-FTHQSDVWSYGVTIWELMTFGGKPYDG-IPTREIPDLLE 934
Query: 802 K-ERFYESRCRPVTPSCK-ELADLMTRCMNYDPNQRPFFRAIMRDINKL 848
K ER P P C ++ +M +C D + RP F+ + + +++
Sbjct: 935 KGERL------PQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRM 977
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 172 bits (437), Expect = 1e-42
Identities = 103/294 (35%), Positives = 157/294 (53%), Gaps = 36/294 (12%)
Query: 879 RDLGEGHFGKV---ELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL-YH 934
+ LGEG FG+V E DP + VAVK LK + +ADL E+E+++ + H
Sbjct: 431 KPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRH 490
Query: 935 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLP---------------KNKNKINLKQ 979
+NI+ G+CT++G + +I+E G+L+E+L ++ ++
Sbjct: 491 KNIINLLGVCTQEGP--LYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPV 548
Query: 980 QLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKD 1039
+ A Q+ +GM YL SR+ +HRDLAARNVLV ++ +KI DFGL + + +YY
Sbjct: 549 LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVH-HIDYYKKTS 607
Query: 1040 DRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQM 1099
+ PV W APE L + SDVWSFG+ L E+ T + G + +
Sbjct: 608 NGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFT--------------LGGSPYPGI 653
Query: 1100 TVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
V L + L+EG R+ PP+CP E+Y LMR+CW PS R +F+ L+E + +L
Sbjct: 654 PVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 707
Score = 73.6 bits (179), Expect = 1e-12
Identities = 76/310 (24%), Positives = 133/310 (42%), Gaps = 45/310 (14%)
Query: 566 PVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLD 625
P+ P+ + DR LV G+ LG G + D + + V + +
Sbjct: 415 PLDPLWEFPRDR-----LVLGKPLGEGCFGQVVRAEAFGM-DPARPDQASTVAVKMLKDN 468
Query: 626 PSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRK--- 682
S +D++ E M HK+I+ L GVC ++ ++ E G L F+ +
Sbjct: 469 ASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPP 528
Query: 683 ------------SDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSE 730
L+ P A Q+A + YLE + +H ++ +N+L+ + +
Sbjct: 529 GPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNV--- 585
Query: 731 CGPFIKLSDPGIPITV----LSRQECIERIP--WIAPECVEDSKNLSVAADKWSFGTTLW 784
+K++D G+ V ++ R+P W+APE + D + + +D WSFG LW
Sbjct: 586 ----MKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFD-RVYTHQSDVWSFGILLW 640
Query: 785 EICYNG-----EIPLKDKTLIEKERFYESRCRPVTPSC-KELADLMTRCMNYDPNQRPFF 838
EI G IP+++ + +E R P C EL LM C + P+QRP F
Sbjct: 641 EIFTLGGSPYPGIPVEELFSLLREGHRMDR----PPHCPPELYGLMRECWHAAPSQRPTF 696
Query: 839 RAIMRDINKL 848
+ ++ ++K+
Sbjct: 697 KQLVEALDKV 706
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 172 bits (437), Expect = 1e-42
Identities = 103/294 (35%), Positives = 157/294 (53%), Gaps = 36/294 (12%)
Query: 879 RDLGEGHFGKV---ELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL-YH 934
+ LGEG FG+V E DP + VAVK LK + +ADL E+E+++ + H
Sbjct: 471 KPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRH 530
Query: 935 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLP---------------KNKNKINLKQ 979
+NI+ G+CT++G + +I+E G+L+E+L ++ ++
Sbjct: 531 KNIINLLGVCTQEGP--LYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPV 588
Query: 980 QLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKD 1039
+ A Q+ +GM YL SR+ +HRDLAARNVLV ++ +KI DFGL + + +YY
Sbjct: 589 LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVH-HIDYYKKTS 647
Query: 1040 DRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQM 1099
+ PV W APE L + SDVWSFG+ L E+ T + G + +
Sbjct: 648 NGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFT--------------LGGSPYPGI 693
Query: 1100 TVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
V L + L+EG R+ PP+CP E+Y LMR+CW PS R +F+ L+E + +L
Sbjct: 694 PVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 747
Score = 73.6 bits (179), Expect = 1e-12
Identities = 76/310 (24%), Positives = 133/310 (42%), Gaps = 45/310 (14%)
Query: 566 PVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLD 625
P+ P+ + DR LV G+ LG G + D + + V + +
Sbjct: 455 PLDPLWEFPRDR-----LVLGKPLGEGCFGQVVRAEAFGM-DPARPDQASTVAVKMLKDN 508
Query: 626 PSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRK--- 682
S +D++ E M HK+I+ L GVC ++ ++ E G L F+ +
Sbjct: 509 ASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPP 568
Query: 683 ------------SDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSE 730
L+ P A Q+A + YLE + +H ++ +N+L+ + +
Sbjct: 569 GPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNV--- 625
Query: 731 CGPFIKLSDPGIPITV----LSRQECIERIP--WIAPECVEDSKNLSVAADKWSFGTTLW 784
+K++D G+ V ++ R+P W+APE + D + + +D WSFG LW
Sbjct: 626 ----MKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFD-RVYTHQSDVWSFGILLW 680
Query: 785 EICYNG-----EIPLKDKTLIEKERFYESRCRPVTPSC-KELADLMTRCMNYDPNQRPFF 838
EI G IP+++ + +E R P C EL LM C + P+QRP F
Sbjct: 681 EIFTLGGSPYPGIPVEELFSLLREGHRMDR----PPHCPPELYGLMRECWHAAPSQRPTF 736
Query: 839 RAIMRDINKL 848
+ ++ ++K+
Sbjct: 737 KQLVEALDKV 746
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 172 bits (437), Expect = 1e-42
Identities = 103/294 (35%), Positives = 157/294 (53%), Gaps = 36/294 (12%)
Query: 879 RDLGEGHFGKV---ELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL-YH 934
+ LGEG FG+V E DP + VAVK LK + +ADL E+E+++ + H
Sbjct: 471 KPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRH 530
Query: 935 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLP---------------KNKNKINLKQ 979
+NI+ G+CT++G + +I+E G+L+E+L ++ ++
Sbjct: 531 KNIINLLGVCTQEGP--LYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPV 588
Query: 980 QLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKD 1039
+ A Q+ +GM YL SR+ +HRDLAARNVLV ++ +KI DFGL + + +YY
Sbjct: 589 LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVH-HIDYYKKTS 647
Query: 1040 DRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQM 1099
+ PV W APE L + SDVWSFG+ L E+ T + G + +
Sbjct: 648 NGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFT--------------LGGSPYPGI 693
Query: 1100 TVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
V L + L+EG R+ PP+CP E+Y LMR+CW PS R +F+ L+E + +L
Sbjct: 694 PVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 747
Score = 73.6 bits (179), Expect = 1e-12
Identities = 76/310 (24%), Positives = 133/310 (42%), Gaps = 45/310 (14%)
Query: 566 PVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLD 625
P+ P+ + DR LV G+ LG G + D + + V + +
Sbjct: 455 PLDPLWEFPRDR-----LVLGKPLGEGCFGQVVRAEAFGM-DPARPDQASTVAVKMLKDN 508
Query: 626 PSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRK--- 682
S +D++ E M HK+I+ L GVC ++ ++ E G L F+ +
Sbjct: 509 ASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPP 568
Query: 683 ------------SDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSE 730
L+ P A Q+A + YLE + +H ++ +N+L+ + +
Sbjct: 569 GPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNV--- 625
Query: 731 CGPFIKLSDPGIPITV----LSRQECIERIP--WIAPECVEDSKNLSVAADKWSFGTTLW 784
+K++D G+ V ++ R+P W+APE + D + + +D WSFG LW
Sbjct: 626 ----MKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFD-RVYTHQSDVWSFGILLW 680
Query: 785 EICYNG-----EIPLKDKTLIEKERFYESRCRPVTPSC-KELADLMTRCMNYDPNQRPFF 838
EI G IP+++ + +E R P C EL LM C + P+QRP F
Sbjct: 681 EIFTLGGSPYPGIPVEELFSLLREGHRMDR----PPHCPPELYGLMRECWHAAPSQRPTF 736
Query: 839 RAIMRDINKL 848
+ ++ ++K+
Sbjct: 737 KQLVEALDKV 746
>gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sapiens]
Length = 1038
Score = 172 bits (435), Expect = 2e-42
Identities = 100/270 (37%), Positives = 149/270 (55%), Gaps = 19/270 (7%)
Query: 875 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPE--SGGNHIADLKKEIEILRNL 932
L+ + LG+G FG V +D T VAVK LKP+ S + D +E+ + +L
Sbjct: 126 LRLLEKLGDGSFGVVRRGEWDAPSGKT-VSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 184
Query: 933 YHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMD 992
H N+++ G+ +K++ E P GSL + L K++ L +YAVQ+ +GM
Sbjct: 185 DHRNLIRLYGVVLTPP---MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMG 241
Query: 993 YLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC 1052
YL S++++HRDLAARN+L+ + VKIGDFGL +A+ + ++Y +++ R P W APE
Sbjct: 242 YLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPES 301
Query: 1053 LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGK 1112
L F ASD W FGVTL E+ TY IG Q+ L KEG+
Sbjct: 302 LKTRTFSHASDTWMFGVTLWEMFTYGQE---------PWIGLNGSQI----LHKIDKEGE 348
Query: 1113 RLPCPPNCPDEVYQLMRKCWEFQPSNRTSF 1142
RLP P +CP ++Y +M +CW +P +R +F
Sbjct: 349 RLPRPEDCPQDIYNVMVQCWAHKPEDRPTF 378
Score = 80.5 bits (197), Expect = 9e-15
Identities = 80/306 (26%), Positives = 134/306 (43%), Gaps = 34/306 (11%)
Query: 580 KKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDP---SHRDISLAFF 636
+KDL E LG G+ + G + K + V +K L P S + F
Sbjct: 123 EKDLRLLEKLGDGSFGVVRRG-------EWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFI 175
Query: 637 EAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLD-LFMHRKSDVLTTPWKFKVA 695
+ M + H++++ LYGV + ++ E G LD L H+ +L T ++ V
Sbjct: 176 REVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAV- 234
Query: 696 KQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECI-- 753
Q+A + YLE K +H ++ +NLLLA + +K+ D G+ + +
Sbjct: 235 -QVAEGMGYLESKRFIHRDLAARNLLLATRDL-------VKIGDFGLMRALPQNDDHYVM 286
Query: 754 ---ERIP--WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIP---LKDKTLIEKERF 805
++P W APE ++ ++ S A+D W FG TLWE+ G+ P L ++ K
Sbjct: 287 QEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK 345
Query: 806 YESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEV 865
R +++ ++M +C + P RP F A +RD L E P + + E
Sbjct: 346 EGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVA-LRDF--LLEAQPTDMRALQDFEEP 402
Query: 866 DPTHFE 871
D H +
Sbjct: 403 DKLHIQ 408
>gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sapiens]
Length = 1086
Score = 172 bits (435), Expect = 2e-42
Identities = 100/270 (37%), Positives = 149/270 (55%), Gaps = 19/270 (7%)
Query: 875 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPE--SGGNHIADLKKEIEILRNL 932
L+ + LG+G FG V +D T VAVK LKP+ S + D +E+ + +L
Sbjct: 189 LRLLEKLGDGSFGVVRRGEWDAPSGKT-VSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 247
Query: 933 YHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMD 992
H N+++ G+ +K++ E P GSL + L K++ L +YAVQ+ +GM
Sbjct: 248 DHRNLIRLYGVVLTPP---MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMG 304
Query: 993 YLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC 1052
YL S++++HRDLAARN+L+ + VKIGDFGL +A+ + ++Y +++ R P W APE
Sbjct: 305 YLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPES 364
Query: 1053 LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGK 1112
L F ASD W FGVTL E+ TY IG Q+ L KEG+
Sbjct: 365 LKTRTFSHASDTWMFGVTLWEMFTYGQE---------PWIGLNGSQI----LHKIDKEGE 411
Query: 1113 RLPCPPNCPDEVYQLMRKCWEFQPSNRTSF 1142
RLP P +CP ++Y +M +CW +P +R +F
Sbjct: 412 RLPRPEDCPQDIYNVMVQCWAHKPEDRPTF 441
Score = 80.5 bits (197), Expect = 9e-15
Identities = 80/306 (26%), Positives = 134/306 (43%), Gaps = 34/306 (11%)
Query: 580 KKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDP---SHRDISLAFF 636
+KDL E LG G+ + G + K + V +K L P S + F
Sbjct: 186 EKDLRLLEKLGDGSFGVVRRG-------EWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFI 238
Query: 637 EAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLD-LFMHRKSDVLTTPWKFKVA 695
+ M + H++++ LYGV + ++ E G LD L H+ +L T ++ V
Sbjct: 239 REVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAV- 297
Query: 696 KQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECI-- 753
Q+A + YLE K +H ++ +NLLLA + +K+ D G+ + +
Sbjct: 298 -QVAEGMGYLESKRFIHRDLAARNLLLATRDL-------VKIGDFGLMRALPQNDDHYVM 349
Query: 754 ---ERIP--WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIP---LKDKTLIEKERF 805
++P W APE ++ ++ S A+D W FG TLWE+ G+ P L ++ K
Sbjct: 350 QEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK 408
Query: 806 YESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEV 865
R +++ ++M +C + P RP F A +RD L E P + + E
Sbjct: 409 EGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVA-LRDF--LLEAQPTDMRALQDFEEP 465
Query: 866 DPTHFE 871
D H +
Sbjct: 466 DKLHIQ 471
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 171 bits (434), Expect = 3e-42
Identities = 104/294 (35%), Positives = 158/294 (53%), Gaps = 36/294 (12%)
Query: 879 RDLGEGHFGKVELCR---YDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL-YH 934
+ LGEG FG+V L D + N +VAVK LK ++ ++DL E+E+++ + H
Sbjct: 391 KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH 450
Query: 935 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK---------------NKINLKQ 979
+NI+ G CT+DG + +I+E+ G+L+EYL + +++ K
Sbjct: 451 KNIINLLGACTQDGP--LYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 508
Query: 980 QLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKD 1039
+ A Q+ +GM+YL S++ +HRDLAARNVLV ++ +KI DFGL + I +YY
Sbjct: 509 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH-HIDYYKKTT 567
Query: 1040 DRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQM 1099
+ PV W APE L + SDVWSFGV L E+ T + G + +
Sbjct: 568 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT--------------LGGSPYPGV 613
Query: 1100 TVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
V L LKEG R+ P NC +E+Y +MR CW PS R +F+ L+E + ++
Sbjct: 614 PVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 667
Score = 84.7 bits (208), Expect = 5e-16
Identities = 81/335 (24%), Positives = 144/335 (42%), Gaps = 43/335 (12%)
Query: 566 PVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVL- 624
P P +L DR LV G+ LG G + + D+ + KV +K+L
Sbjct: 375 PEDPRWELPRDR-----LVLGKPLGEGCFGQVVLAEAIGLDKDK---PNRVTKVAVKMLK 426
Query: 625 -DPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFM---- 679
D + +D+S E M HK+I+ L G C +D ++ E+ G L ++
Sbjct: 427 SDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR 486
Query: 680 -----------HRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGID 728
H + L++ A Q+A + YL K +H ++ +N+L+ + +
Sbjct: 487 PPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV- 545
Query: 729 SECGPFIKLSDPGIPITV----LSRQECIERIP--WIAPECVEDSKNLSVAADKWSFGTT 782
+K++D G+ + ++ R+P W+APE + D + + +D WSFG
Sbjct: 546 ------MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVL 598
Query: 783 LWEICYNGEIPLKDKTLIEKERFYESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRA 840
LWEI G P + E + + R PS EL +M C + P+QRP F+
Sbjct: 599 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 658
Query: 841 IMRDINKLE--EQNPDIVSEKKPATEVDPTHFEKR 873
++ D++++ N + + P + P+ + R
Sbjct: 659 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTR 693
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 171 bits (434), Expect = 3e-42
Identities = 104/294 (35%), Positives = 158/294 (53%), Gaps = 36/294 (12%)
Query: 879 RDLGEGHFGKVELCR---YDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL-YH 934
+ LGEG FG+V L D + N +VAVK LK ++ ++DL E+E+++ + H
Sbjct: 393 KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH 452
Query: 935 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK---------------NKINLKQ 979
+NI+ G CT+DG + +I+E+ G+L+EYL + +++ K
Sbjct: 453 KNIINLLGACTQDGP--LYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 510
Query: 980 QLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKD 1039
+ A Q+ +GM+YL S++ +HRDLAARNVLV ++ +KI DFGL + I +YY
Sbjct: 511 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH-HIDYYKKTT 569
Query: 1040 DRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQM 1099
+ PV W APE L + SDVWSFGV L E+ T + G + +
Sbjct: 570 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT--------------LGGSPYPGV 615
Query: 1100 TVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
V L LKEG R+ P NC +E+Y +MR CW PS R +F+ L+E + ++
Sbjct: 616 PVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 669
Score = 84.7 bits (208), Expect = 5e-16
Identities = 81/335 (24%), Positives = 144/335 (42%), Gaps = 43/335 (12%)
Query: 566 PVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVL- 624
P P +L DR LV G+ LG G + + D+ + KV +K+L
Sbjct: 377 PEDPRWELPRDR-----LVLGKPLGEGCFGQVVLAEAIGLDKDK---PNRVTKVAVKMLK 428
Query: 625 -DPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFM---- 679
D + +D+S E M HK+I+ L G C +D ++ E+ G L ++
Sbjct: 429 SDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR 488
Query: 680 -----------HRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGID 728
H + L++ A Q+A + YL K +H ++ +N+L+ + +
Sbjct: 489 PPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV- 547
Query: 729 SECGPFIKLSDPGIPITV----LSRQECIERIP--WIAPECVEDSKNLSVAADKWSFGTT 782
+K++D G+ + ++ R+P W+APE + D + + +D WSFG
Sbjct: 548 ------MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVL 600
Query: 783 LWEICYNGEIPLKDKTLIEKERFYESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRA 840
LWEI G P + E + + R PS EL +M C + P+QRP F+
Sbjct: 601 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 660
Query: 841 IMRDINKLE--EQNPDIVSEKKPATEVDPTHFEKR 873
++ D++++ N + + P + P+ + R
Sbjct: 661 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTR 695
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 171 bits (434), Expect = 3e-42
Identities = 104/294 (35%), Positives = 158/294 (53%), Gaps = 36/294 (12%)
Query: 879 RDLGEGHFGKVELCR---YDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL-YH 934
+ LGEG FG+V L D + N +VAVK LK ++ ++DL E+E+++ + H
Sbjct: 480 KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH 539
Query: 935 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK---------------NKINLKQ 979
+NI+ G CT+DG + +I+E+ G+L+EYL + +++ K
Sbjct: 540 KNIINLLGACTQDGP--LYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 597
Query: 980 QLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKD 1039
+ A Q+ +GM+YL S++ +HRDLAARNVLV ++ +KI DFGL + I +YY
Sbjct: 598 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH-HIDYYKKTT 656
Query: 1040 DRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQM 1099
+ PV W APE L + SDVWSFGV L E+ T + G + +
Sbjct: 657 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT--------------LGGSPYPGV 702
Query: 1100 TVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
V L LKEG R+ P NC +E+Y +MR CW PS R +F+ L+E + ++
Sbjct: 703 PVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 756
Score = 84.7 bits (208), Expect = 5e-16
Identities = 81/335 (24%), Positives = 144/335 (42%), Gaps = 43/335 (12%)
Query: 566 PVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVL- 624
P P +L DR LV G+ LG G + + D+ + KV +K+L
Sbjct: 464 PEDPRWELPRDR-----LVLGKPLGEGCFGQVVLAEAIGLDKDK---PNRVTKVAVKMLK 515
Query: 625 -DPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFM---- 679
D + +D+S E M HK+I+ L G C +D ++ E+ G L ++
Sbjct: 516 SDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR 575
Query: 680 -----------HRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGID 728
H + L++ A Q+A + YL K +H ++ +N+L+ + +
Sbjct: 576 PPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV- 634
Query: 729 SECGPFIKLSDPGIPITV----LSRQECIERIP--WIAPECVEDSKNLSVAADKWSFGTT 782
+K++D G+ + ++ R+P W+APE + D + + +D WSFG
Sbjct: 635 ------MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVL 687
Query: 783 LWEICYNGEIPLKDKTLIEKERFYESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRA 840
LWEI G P + E + + R PS EL +M C + P+QRP F+
Sbjct: 688 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 747
Query: 841 IMRDINKLE--EQNPDIVSEKKPATEVDPTHFEKR 873
++ D++++ N + + P + P+ + R
Sbjct: 748 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTR 782
>gi|105990522 fibroblast growth factor receptor 1 isoform 1 precursor
[Homo sapiens]
Length = 822
Score = 171 bits (434), Expect = 3e-42
Identities = 104/294 (35%), Positives = 158/294 (53%), Gaps = 36/294 (12%)
Query: 879 RDLGEGHFGKVELCR---YDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL-YH 934
+ LGEG FG+V L D + N +VAVK LK ++ ++DL E+E+++ + H
Sbjct: 482 KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH 541
Query: 935 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK---------------NKINLKQ 979
+NI+ G CT+DG + +I+E+ G+L+EYL + +++ K
Sbjct: 542 KNIINLLGACTQDGP--LYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 599
Query: 980 QLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKD 1039
+ A Q+ +GM+YL S++ +HRDLAARNVLV ++ +KI DFGL + I +YY
Sbjct: 600 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH-HIDYYKKTT 658
Query: 1040 DRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQM 1099
+ PV W APE L + SDVWSFGV L E+ T + G + +
Sbjct: 659 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT--------------LGGSPYPGV 704
Query: 1100 TVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
V L LKEG R+ P NC +E+Y +MR CW PS R +F+ L+E + ++
Sbjct: 705 PVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 758
Score = 84.7 bits (208), Expect = 5e-16
Identities = 81/335 (24%), Positives = 144/335 (42%), Gaps = 43/335 (12%)
Query: 566 PVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVL- 624
P P +L DR LV G+ LG G + + D+ + KV +K+L
Sbjct: 466 PEDPRWELPRDR-----LVLGKPLGEGCFGQVVLAEAIGLDKDK---PNRVTKVAVKMLK 517
Query: 625 -DPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFM---- 679
D + +D+S E M HK+I+ L G C +D ++ E+ G L ++
Sbjct: 518 SDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR 577
Query: 680 -----------HRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGID 728
H + L++ A Q+A + YL K +H ++ +N+L+ + +
Sbjct: 578 PPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV- 636
Query: 729 SECGPFIKLSDPGIPITV----LSRQECIERIP--WIAPECVEDSKNLSVAADKWSFGTT 782
+K++D G+ + ++ R+P W+APE + D + + +D WSFG
Sbjct: 637 ------MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVL 689
Query: 783 LWEICYNGEIPLKDKTLIEKERFYESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRA 840
LWEI G P + E + + R PS EL +M C + P+QRP F+
Sbjct: 690 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 749
Query: 841 IMRDINKLE--EQNPDIVSEKKPATEVDPTHFEKR 873
++ D++++ N + + P + P+ + R
Sbjct: 750 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTR 784
>gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2
[Homo sapiens]
Length = 312
Score = 169 bits (429), Expect = 1e-41
Identities = 101/290 (34%), Positives = 151/290 (52%), Gaps = 25/290 (8%)
Query: 859 KKPATEVDPTHFEKRFLKRIR------DLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKP 912
+ P ++ + +K FLKR +LG G+FG V Y VA+K LK
Sbjct: 9 ESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQI--DVAIKVLKQ 66
Query: 913 ESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK 972
+ ++ +E +I+ L + IV+ G+C + + L+ME G L ++L +
Sbjct: 67 GTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA---LMLVMEMAGGGPLHKFLVGKR 123
Query: 973 NKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDK 1032
+I + + Q+ GM YL + +VHRDLAARNVL+ + H KI DFGL+KA+ D
Sbjct: 124 EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADD 183
Query: 1033 EYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMI 1092
YYT + P+ WYAPEC+ KF SDVWS+GVT+ E L+Y + KM
Sbjct: 184 SYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKP------YKKMK 237
Query: 1093 GPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSF 1142
GP ++ +++GKR+ CPP CP E+Y LM CW ++ +R F
Sbjct: 238 GP--------EVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 279
Score = 88.2 bits (217), Expect = 4e-17
Identities = 69/240 (28%), Positives = 111/240 (46%), Gaps = 23/240 (9%)
Query: 614 EKKIKVILKVLDP-SHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEG 672
+K+I V +KVL + + + A +M Q+ + +IV L GVC + ++V E G
Sbjct: 54 KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEAL-MLVMEMAGG 112
Query: 673 GPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECG 732
GPL F+ K + + ++ Q++ + YLE+K+ VH ++ +N+LL
Sbjct: 113 GPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNR------- 165
Query: 733 PFIKLSDPGIPITV-------LSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWE 785
+ K+SD G+ + +R + W APEC+ + + S +D WS+G T+WE
Sbjct: 166 HYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKFSSRSDVWSYGVTMWE 224
Query: 786 ICYNGEIPLKDKTLIEKERFYES----RCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI 841
G+ P K E F E C P P EL LM+ C Y RP F +
Sbjct: 225 ALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP--PELYALMSDCWIYKWEDRPDFLTV 282
>gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1
[Homo sapiens]
Length = 619
Score = 169 bits (429), Expect = 1e-41
Identities = 101/290 (34%), Positives = 151/290 (52%), Gaps = 25/290 (8%)
Query: 859 KKPATEVDPTHFEKRFLKRIR------DLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKP 912
+ P ++ + +K FLKR +LG G+FG V Y VA+K LK
Sbjct: 316 ESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQI--DVAIKVLKQ 373
Query: 913 ESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK 972
+ ++ +E +I+ L + IV+ G+C + + L+ME G L ++L +
Sbjct: 374 GTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA---LMLVMEMAGGGPLHKFLVGKR 430
Query: 973 NKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDK 1032
+I + + Q+ GM YL + +VHRDLAARNVL+ + H KI DFGL+KA+ D
Sbjct: 431 EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADD 490
Query: 1033 EYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMI 1092
YYT + P+ WYAPEC+ KF SDVWS+GVT+ E L+Y + KM
Sbjct: 491 SYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKP------YKKMK 544
Query: 1093 GPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSF 1142
GP ++ +++GKR+ CPP CP E+Y LM CW ++ +R F
Sbjct: 545 GP--------EVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586
Score = 88.2 bits (217), Expect = 4e-17
Identities = 69/240 (28%), Positives = 111/240 (46%), Gaps = 23/240 (9%)
Query: 614 EKKIKVILKVLDP-SHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEG 672
+K+I V +KVL + + + A +M Q+ + +IV L GVC + ++V E G
Sbjct: 361 KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEAL-MLVMEMAGG 419
Query: 673 GPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECG 732
GPL F+ K + + ++ Q++ + YLE+K+ VH ++ +N+LL
Sbjct: 420 GPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNR------- 472
Query: 733 PFIKLSDPGIPITV-------LSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWE 785
+ K+SD G+ + +R + W APEC+ + + S +D WS+G T+WE
Sbjct: 473 HYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKFSSRSDVWSYGVTMWE 531
Query: 786 ICYNGEIPLKDKTLIEKERFYES----RCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI 841
G+ P K E F E C P P EL LM+ C Y RP F +
Sbjct: 532 ALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP--PELYALMSDCWIYKWEDRPDFLTV 589
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform b
precursor [Homo sapiens]
Length = 825
Score = 169 bits (428), Expect = 1e-41
Identities = 111/311 (35%), Positives = 162/311 (52%), Gaps = 36/311 (11%)
Query: 860 KPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCR-YDPEGDNTGEQVAVKSLKPESGGNH 918
KP T V H ++R + R+LGEG FGKV L Y+ VAVK+LK +
Sbjct: 525 KPDTYVQ--HIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAAR 582
Query: 919 IADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKN------- 971
D ++E E+L NL HE+IVK+ G+C + G+ + ++ E++ G L ++L +
Sbjct: 583 -KDFQREAELLTNLQHEHIVKFYGVCGD--GDPLIMVFEYMKHGDLNKFLRAHGPDAMIL 639
Query: 972 --------KNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFG 1023
K ++ L Q L A QI GM YL S+ +VHRDLA RN LV + VKIGDFG
Sbjct: 640 VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFG 699
Query: 1024 LTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSS 1083
+++ + + +YY V P+ W PE +M KF SDVWSFGV L E+ TY
Sbjct: 700 MSRDVYS-TDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTY---GKQ 755
Query: 1084 PMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQ 1143
P Q++ T ++ + +G+ L P CP EVY +M CW+ +P R + +
Sbjct: 756 PWF-----------QLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIK 804
Query: 1144 NLIEGFEALLK 1154
+ + AL K
Sbjct: 805 EIYKILHALGK 815
Score = 79.7 bits (195), Expect = 1e-14
Identities = 78/301 (25%), Positives = 125/301 (41%), Gaps = 40/301 (13%)
Query: 578 ILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFE 637
I ++D+V LG G ++ + + + K+ V +K L F
Sbjct: 533 IKRRDIVLKRELGEGAFGKVFLAECYNL-----SPTKDKMLVAVKALKDPTLAARKDFQR 587
Query: 638 AASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFM---------------HRK 682
A ++ + H+HIV YGVC IMV E+++ G L+ F+ +
Sbjct: 588 EAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQA 647
Query: 683 SDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGI 742
L +A Q+AS + YL + VH ++ T+N L+ +K+ D G+
Sbjct: 648 KGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVG-------ANLLVKIGDFGM 700
Query: 743 PITVLSRQ------ECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIP--- 793
V S + I W+ PE + K + +D WSFG LWEI G+ P
Sbjct: 701 SRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK-FTTESDVWSFGVILWEIFTYGKQPWFQ 759
Query: 794 LKDKTLIEKERFYESRCRP-VTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQN 852
L + +IE RP V P KE+ D+M C +P QR + I + ++ L +
Sbjct: 760 LSNTEVIECITQGRVLERPRVCP--KEVYDVMLGCWQREPQQRLNIKEIYKILHALGKAT 817
Query: 853 P 853
P
Sbjct: 818 P 818
>gi|222144244 fibroblast growth factor receptor 2 isoform 9 precursor
[Homo sapiens]
Length = 680
Score = 167 bits (423), Expect = 5e-41
Identities = 102/294 (34%), Positives = 154/294 (52%), Gaps = 36/294 (12%)
Query: 879 RDLGEGHFGKV---ELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL-YH 934
+ LGEG FG+V E D + VAVK LK ++ ++DL E+E+++ + H
Sbjct: 397 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 456
Query: 935 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK---------------NKINLKQ 979
+NI+ G CT+DG + +I+E+ G+L+EYL + ++ K
Sbjct: 457 KNIINLLGACTQDGP--LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 514
Query: 980 QLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKD 1039
+ Q+ +GM+YL S++ +HRDLAARNVLV + +KI DFGL + I + +YY
Sbjct: 515 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI-NNIDYYKKTT 573
Query: 1040 DRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQM 1099
+ PV W APE L + SDVWSFGV + E+ T + G + +
Sbjct: 574 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT--------------LGGSPYPGI 619
Query: 1100 TVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
V L LKEG R+ P NC +E+Y +MR CW PS R +F+ L+E + +L
Sbjct: 620 PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 673
Score = 75.1 bits (183), Expect = 4e-13
Identities = 68/291 (23%), Positives = 129/291 (44%), Gaps = 36/291 (12%)
Query: 583 LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVL--DPSHRDISLAFFEAAS 640
L G+ LG G + + D+ ++ + V +K+L D + +D+S E
Sbjct: 393 LTLGKPLGEGCFGQVVMAEAVGIDKDK---PKEAVTVAVKMLKDDATEKDLSDLVSEMEM 449
Query: 641 MMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKS--------DVLTTPWKF 692
M HK+I+ L G C +D ++ E+ G L ++ + D+ P +
Sbjct: 450 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 509
Query: 693 KVAK-------QLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPIT 745
K QLA + YL + +H ++ +N+L+ + +K++D G+
Sbjct: 510 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV-------MKIADFGLARD 562
Query: 746 VLS----RQECIERIP--WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTL 799
+ + ++ R+P W+APE + D + + +D WSFG +WEI G P +
Sbjct: 563 INNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 621
Query: 800 IEKERFYESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRAIMRDINKL 848
E + + R P+ EL +M C + P+QRP F+ ++ D++++
Sbjct: 622 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 672
>gi|222144231 fibroblast growth factor receptor 2 isoform 3 precursor
[Homo sapiens]
Length = 769
Score = 167 bits (423), Expect = 5e-41
Identities = 102/294 (34%), Positives = 154/294 (52%), Gaps = 36/294 (12%)
Query: 879 RDLGEGHFGKV---ELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL-YH 934
+ LGEG FG+V E D + VAVK LK ++ ++DL E+E+++ + H
Sbjct: 486 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 545
Query: 935 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK---------------NKINLKQ 979
+NI+ G CT+DG + +I+E+ G+L+EYL + ++ K
Sbjct: 546 KNIINLLGACTQDGP--LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 603
Query: 980 QLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKD 1039
+ Q+ +GM+YL S++ +HRDLAARNVLV + +KI DFGL + I + +YY
Sbjct: 604 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI-NNIDYYKKTT 662
Query: 1040 DRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQM 1099
+ PV W APE L + SDVWSFGV + E+ T + G + +
Sbjct: 663 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT--------------LGGSPYPGI 708
Query: 1100 TVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
V L LKEG R+ P NC +E+Y +MR CW PS R +F+ L+E + +L
Sbjct: 709 PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762
Score = 75.1 bits (183), Expect = 4e-13
Identities = 68/291 (23%), Positives = 129/291 (44%), Gaps = 36/291 (12%)
Query: 583 LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVL--DPSHRDISLAFFEAAS 640
L G+ LG G + + D+ ++ + V +K+L D + +D+S E
Sbjct: 482 LTLGKPLGEGCFGQVVMAEAVGIDKDK---PKEAVTVAVKMLKDDATEKDLSDLVSEMEM 538
Query: 641 MMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKS--------DVLTTPWKF 692
M HK+I+ L G C +D ++ E+ G L ++ + D+ P +
Sbjct: 539 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 598
Query: 693 KVAK-------QLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPIT 745
K QLA + YL + +H ++ +N+L+ + +K++D G+
Sbjct: 599 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV-------MKIADFGLARD 651
Query: 746 VLS----RQECIERIP--WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTL 799
+ + ++ R+P W+APE + D + + +D WSFG +WEI G P +
Sbjct: 652 INNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 710
Query: 800 IEKERFYESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRAIMRDINKL 848
E + + R P+ EL +M C + P+QRP F+ ++ D++++
Sbjct: 711 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 761
>gi|222144241 fibroblast growth factor receptor 2 isoform 8 precursor
[Homo sapiens]
Length = 704
Score = 167 bits (423), Expect = 5e-41
Identities = 102/294 (34%), Positives = 154/294 (52%), Gaps = 36/294 (12%)
Query: 879 RDLGEGHFGKV---ELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL-YH 934
+ LGEG FG+V E D + VAVK LK ++ ++DL E+E+++ + H
Sbjct: 368 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 427
Query: 935 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK---------------NKINLKQ 979
+NI+ G CT+DG + +I+E+ G+L+EYL + ++ K
Sbjct: 428 KNIINLLGACTQDGP--LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 485
Query: 980 QLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKD 1039
+ Q+ +GM+YL S++ +HRDLAARNVLV + +KI DFGL + I + +YY
Sbjct: 486 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI-NNIDYYKKTT 544
Query: 1040 DRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQM 1099
+ PV W APE L + SDVWSFGV + E+ T + G + +
Sbjct: 545 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT--------------LGGSPYPGI 590
Query: 1100 TVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
V L LKEG R+ P NC +E+Y +MR CW PS R +F+ L+E + +L
Sbjct: 591 PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 644
Score = 77.0 bits (188), Expect = 9e-14
Identities = 72/318 (22%), Positives = 140/318 (44%), Gaps = 38/318 (11%)
Query: 583 LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVL--DPSHRDISLAFFEAAS 640
L G+ LG G + + D+ ++ + V +K+L D + +D+S E
Sbjct: 364 LTLGKPLGEGCFGQVVMAEAVGIDKDK---PKEAVTVAVKMLKDDATEKDLSDLVSEMEM 420
Query: 641 MMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKS--------DVLTTPWKF 692
M HK+I+ L G C +D ++ E+ G L ++ + D+ P +
Sbjct: 421 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 480
Query: 693 KVAK-------QLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPIT 745
K QLA + YL + +H ++ +N+L+ + +K++D G+
Sbjct: 481 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV-------MKIADFGLARD 533
Query: 746 VLS----RQECIERIP--WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTL 799
+ + ++ R+P W+APE + D + + +D WSFG +WEI G P +
Sbjct: 534 INNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 592
Query: 800 IEKERFYESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRAIMRDINKL--EEQNPDI 855
E + + R P+ EL +M C + P+QRP F+ ++ D++++ N +
Sbjct: 593 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 652
Query: 856 VSEKKPATEVDPTHFEKR 873
+ +P + P++ + R
Sbjct: 653 LDLSQPLEQYSPSYPDTR 670
>gi|222144239 fibroblast growth factor receptor 2 isoform 7 precursor
[Homo sapiens]
Length = 705
Score = 167 bits (423), Expect = 5e-41
Identities = 102/294 (34%), Positives = 154/294 (52%), Gaps = 36/294 (12%)
Query: 879 RDLGEGHFGKV---ELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL-YH 934
+ LGEG FG+V E D + VAVK LK ++ ++DL E+E+++ + H
Sbjct: 369 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 428
Query: 935 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK---------------NKINLKQ 979
+NI+ G CT+DG + +I+E+ G+L+EYL + ++ K
Sbjct: 429 KNIINLLGACTQDGP--LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 486
Query: 980 QLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKD 1039
+ Q+ +GM+YL S++ +HRDLAARNVLV + +KI DFGL + I + +YY
Sbjct: 487 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI-NNIDYYKKTT 545
Query: 1040 DRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQM 1099
+ PV W APE L + SDVWSFGV + E+ T + G + +
Sbjct: 546 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT--------------LGGSPYPGI 591
Query: 1100 TVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
V L LKEG R+ P NC +E+Y +MR CW PS R +F+ L+E + +L
Sbjct: 592 PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 645
Score = 77.0 bits (188), Expect = 9e-14
Identities = 72/318 (22%), Positives = 140/318 (44%), Gaps = 38/318 (11%)
Query: 583 LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVL--DPSHRDISLAFFEAAS 640
L G+ LG G + + D+ ++ + V +K+L D + +D+S E
Sbjct: 365 LTLGKPLGEGCFGQVVMAEAVGIDKDK---PKEAVTVAVKMLKDDATEKDLSDLVSEMEM 421
Query: 641 MMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKS--------DVLTTPWKF 692
M HK+I+ L G C +D ++ E+ G L ++ + D+ P +
Sbjct: 422 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 481
Query: 693 KVAK-------QLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPIT 745
K QLA + YL + +H ++ +N+L+ + +K++D G+
Sbjct: 482 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV-------MKIADFGLARD 534
Query: 746 VLS----RQECIERIP--WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTL 799
+ + ++ R+P W+APE + D + + +D WSFG +WEI G P +
Sbjct: 535 INNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 593
Query: 800 IEKERFYESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRAIMRDINKL--EEQNPDI 855
E + + R P+ EL +M C + P+QRP F+ ++ D++++ N +
Sbjct: 594 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 653
Query: 856 VSEKKPATEVDPTHFEKR 873
+ +P + P++ + R
Sbjct: 654 LDLSQPLEQYSPSYPDTR 671
>gi|222144237 fibroblast growth factor receptor 2 isoform 6 precursor
[Homo sapiens]
Length = 706
Score = 167 bits (423), Expect = 5e-41
Identities = 102/294 (34%), Positives = 154/294 (52%), Gaps = 36/294 (12%)
Query: 879 RDLGEGHFGKV---ELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL-YH 934
+ LGEG FG+V E D + VAVK LK ++ ++DL E+E+++ + H
Sbjct: 370 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 429
Query: 935 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK---------------NKINLKQ 979
+NI+ G CT+DG + +I+E+ G+L+EYL + ++ K
Sbjct: 430 KNIINLLGACTQDGP--LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 487
Query: 980 QLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKD 1039
+ Q+ +GM+YL S++ +HRDLAARNVLV + +KI DFGL + I + +YY
Sbjct: 488 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI-NNIDYYKKTT 546
Query: 1040 DRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQM 1099
+ PV W APE L + SDVWSFGV + E+ T + G + +
Sbjct: 547 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT--------------LGGSPYPGI 592
Query: 1100 TVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
V L LKEG R+ P NC +E+Y +MR CW PS R +F+ L+E + +L
Sbjct: 593 PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 646
Score = 77.0 bits (188), Expect = 9e-14
Identities = 72/318 (22%), Positives = 140/318 (44%), Gaps = 38/318 (11%)
Query: 583 LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVL--DPSHRDISLAFFEAAS 640
L G+ LG G + + D+ ++ + V +K+L D + +D+S E
Sbjct: 366 LTLGKPLGEGCFGQVVMAEAVGIDKDK---PKEAVTVAVKMLKDDATEKDLSDLVSEMEM 422
Query: 641 MMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKS--------DVLTTPWKF 692
M HK+I+ L G C +D ++ E+ G L ++ + D+ P +
Sbjct: 423 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 482
Query: 693 KVAK-------QLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPIT 745
K QLA + YL + +H ++ +N+L+ + +K++D G+
Sbjct: 483 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV-------MKIADFGLARD 535
Query: 746 VLS----RQECIERIP--WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTL 799
+ + ++ R+P W+APE + D + + +D WSFG +WEI G P +
Sbjct: 536 INNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 594
Query: 800 IEKERFYESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRAIMRDINKL--EEQNPDI 855
E + + R P+ EL +M C + P+QRP F+ ++ D++++ N +
Sbjct: 595 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 654
Query: 856 VSEKKPATEVDPTHFEKR 873
+ +P + P++ + R
Sbjct: 655 LDLSQPLEQYSPSYPDTR 672
>gi|222144235 fibroblast growth factor receptor 2 isoform 5 precursor
[Homo sapiens]
Length = 707
Score = 167 bits (423), Expect = 5e-41
Identities = 102/294 (34%), Positives = 154/294 (52%), Gaps = 36/294 (12%)
Query: 879 RDLGEGHFGKV---ELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL-YH 934
+ LGEG FG+V E D + VAVK LK ++ ++DL E+E+++ + H
Sbjct: 396 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 455
Query: 935 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK---------------NKINLKQ 979
+NI+ G CT+DG + +I+E+ G+L+EYL + ++ K
Sbjct: 456 KNIINLLGACTQDGP--LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 513
Query: 980 QLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKD 1039
+ Q+ +GM+YL S++ +HRDLAARNVLV + +KI DFGL + I + +YY
Sbjct: 514 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI-NNIDYYKKTT 572
Query: 1040 DRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQM 1099
+ PV W APE L + SDVWSFGV + E+ T + G + +
Sbjct: 573 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT--------------LGGSPYPGI 618
Query: 1100 TVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
V L LKEG R+ P NC +E+Y +MR CW PS R +F+ L+E + +L
Sbjct: 619 PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 672
Score = 75.5 bits (184), Expect = 3e-13
Identities = 73/309 (23%), Positives = 136/309 (44%), Gaps = 37/309 (11%)
Query: 583 LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVL--DPSHRDISLAFFEAAS 640
L G+ LG G + + D+ ++ + V +K+L D + +D+S E
Sbjct: 392 LTLGKPLGEGCFGQVVMAEAVGIDKDK---PKEAVTVAVKMLKDDATEKDLSDLVSEMEM 448
Query: 641 MMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKS--------DVLTTPWKF 692
M HK+I+ L G C +D ++ E+ G L ++ + D+ P +
Sbjct: 449 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 508
Query: 693 KVAK-------QLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPIT 745
K QLA + YL + +H ++ +N+L+ + +K++D G+
Sbjct: 509 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV-------MKIADFGLARD 561
Query: 746 VLS----RQECIERIP--WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTL 799
+ + ++ R+P W+APE + D + + +D WSFG +WEI G P +
Sbjct: 562 INNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 620
Query: 800 IEKERFYESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVS 857
E + + R P+ EL +M C + P+QRP F+ ++ D++++ +
Sbjct: 621 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTN-EE 679
Query: 858 EKKPATEVD 866
EKK + VD
Sbjct: 680 EKKVSGAVD 688
>gi|222144233 fibroblast growth factor receptor 2 isoform 4 precursor
[Homo sapiens]
Length = 709
Score = 167 bits (423), Expect = 5e-41
Identities = 102/294 (34%), Positives = 154/294 (52%), Gaps = 36/294 (12%)
Query: 879 RDLGEGHFGKV---ELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL-YH 934
+ LGEG FG+V E D + VAVK LK ++ ++DL E+E+++ + H
Sbjct: 373 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 432
Query: 935 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK---------------NKINLKQ 979
+NI+ G CT+DG + +I+E+ G+L+EYL + ++ K
Sbjct: 433 KNIINLLGACTQDGP--LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 490
Query: 980 QLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKD 1039
+ Q+ +GM+YL S++ +HRDLAARNVLV + +KI DFGL + I + +YY
Sbjct: 491 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI-NNIDYYKKTT 549
Query: 1040 DRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQM 1099
+ PV W APE L + SDVWSFGV + E+ T + G + +
Sbjct: 550 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT--------------LGGSPYPGI 595
Query: 1100 TVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
V L LKEG R+ P NC +E+Y +MR CW PS R +F+ L+E + +L
Sbjct: 596 PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 649
Score = 77.0 bits (188), Expect = 9e-14
Identities = 72/318 (22%), Positives = 140/318 (44%), Gaps = 38/318 (11%)
Query: 583 LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVL--DPSHRDISLAFFEAAS 640
L G+ LG G + + D+ ++ + V +K+L D + +D+S E
Sbjct: 369 LTLGKPLGEGCFGQVVMAEAVGIDKDK---PKEAVTVAVKMLKDDATEKDLSDLVSEMEM 425
Query: 641 MMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKS--------DVLTTPWKF 692
M HK+I+ L G C +D ++ E+ G L ++ + D+ P +
Sbjct: 426 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 485
Query: 693 KVAK-------QLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPIT 745
K QLA + YL + +H ++ +N+L+ + +K++D G+
Sbjct: 486 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV-------MKIADFGLARD 538
Query: 746 VLS----RQECIERIP--WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTL 799
+ + ++ R+P W+APE + D + + +D WSFG +WEI G P +
Sbjct: 539 INNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 597
Query: 800 IEKERFYESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRAIMRDINKL--EEQNPDI 855
E + + R P+ EL +M C + P+QRP F+ ++ D++++ N +
Sbjct: 598 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 657
Query: 856 VSEKKPATEVDPTHFEKR 873
+ +P + P++ + R
Sbjct: 658 LDLSQPLEQYSPSYPDTR 675
>gi|221316639 fibroblast growth factor receptor 2 isoform 1 precursor
[Homo sapiens]
Length = 821
Score = 167 bits (423), Expect = 5e-41
Identities = 102/294 (34%), Positives = 154/294 (52%), Gaps = 36/294 (12%)
Query: 879 RDLGEGHFGKV---ELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL-YH 934
+ LGEG FG+V E D + VAVK LK ++ ++DL E+E+++ + H
Sbjct: 485 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 544
Query: 935 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK---------------NKINLKQ 979
+NI+ G CT+DG + +I+E+ G+L+EYL + ++ K
Sbjct: 545 KNIINLLGACTQDGP--LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 602
Query: 980 QLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKD 1039
+ Q+ +GM+YL S++ +HRDLAARNVLV + +KI DFGL + I + +YY
Sbjct: 603 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI-NNIDYYKKTT 661
Query: 1040 DRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQM 1099
+ PV W APE L + SDVWSFGV + E+ T + G + +
Sbjct: 662 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT--------------LGGSPYPGI 707
Query: 1100 TVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
V L LKEG R+ P NC +E+Y +MR CW PS R +F+ L+E + +L
Sbjct: 708 PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 761
Score = 77.0 bits (188), Expect = 9e-14
Identities = 72/318 (22%), Positives = 140/318 (44%), Gaps = 38/318 (11%)
Query: 583 LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVL--DPSHRDISLAFFEAAS 640
L G+ LG G + + D+ ++ + V +K+L D + +D+S E
Sbjct: 481 LTLGKPLGEGCFGQVVMAEAVGIDKDK---PKEAVTVAVKMLKDDATEKDLSDLVSEMEM 537
Query: 641 MMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKS--------DVLTTPWKF 692
M HK+I+ L G C +D ++ E+ G L ++ + D+ P +
Sbjct: 538 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 597
Query: 693 KVAK-------QLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPIT 745
K QLA + YL + +H ++ +N+L+ + +K++D G+
Sbjct: 598 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV-------MKIADFGLARD 650
Query: 746 VLS----RQECIERIP--WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTL 799
+ + ++ R+P W+APE + D + + +D WSFG +WEI G P +
Sbjct: 651 INNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 709
Query: 800 IEKERFYESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRAIMRDINKL--EEQNPDI 855
E + + R P+ EL +M C + P+QRP F+ ++ D++++ N +
Sbjct: 710 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 769
Query: 856 VSEKKPATEVDPTHFEKR 873
+ +P + P++ + R
Sbjct: 770 LDLSQPLEQYSPSYPDTR 787
>gi|221316638 fibroblast growth factor receptor 2 isoform 2 precursor
[Homo sapiens]
Length = 822
Score = 167 bits (423), Expect = 5e-41
Identities = 102/294 (34%), Positives = 154/294 (52%), Gaps = 36/294 (12%)
Query: 879 RDLGEGHFGKV---ELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL-YH 934
+ LGEG FG+V E D + VAVK LK ++ ++DL E+E+++ + H
Sbjct: 486 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 545
Query: 935 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK---------------NKINLKQ 979
+NI+ G CT+DG + +I+E+ G+L+EYL + ++ K
Sbjct: 546 KNIINLLGACTQDGP--LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 603
Query: 980 QLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKD 1039
+ Q+ +GM+YL S++ +HRDLAARNVLV + +KI DFGL + I + +YY
Sbjct: 604 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI-NNIDYYKKTT 662
Query: 1040 DRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQM 1099
+ PV W APE L + SDVWSFGV + E+ T + G + +
Sbjct: 663 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT--------------LGGSPYPGI 708
Query: 1100 TVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 1153
V L LKEG R+ P NC +E+Y +MR CW PS R +F+ L+E + +L
Sbjct: 709 PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762
Score = 77.0 bits (188), Expect = 9e-14
Identities = 72/318 (22%), Positives = 140/318 (44%), Gaps = 38/318 (11%)
Query: 583 LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVL--DPSHRDISLAFFEAAS 640
L G+ LG G + + D+ ++ + V +K+L D + +D+S E
Sbjct: 482 LTLGKPLGEGCFGQVVMAEAVGIDKDK---PKEAVTVAVKMLKDDATEKDLSDLVSEMEM 538
Query: 641 MMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKS--------DVLTTPWKF 692
M HK+I+ L G C +D ++ E+ G L ++ + D+ P +
Sbjct: 539 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 598
Query: 693 KVAK-------QLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPIT 745
K QLA + YL + +H ++ +N+L+ + +K++D G+
Sbjct: 599 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV-------MKIADFGLARD 651
Query: 746 VLS----RQECIERIP--WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTL 799
+ + ++ R+P W+APE + D + + +D WSFG +WEI G P +
Sbjct: 652 INNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 710
Query: 800 IEKERFYESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRAIMRDINKL--EEQNPDI 855
E + + R P+ EL +M C + P+QRP F+ ++ D++++ N +
Sbjct: 711 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 770
Query: 856 VSEKKPATEVDPTHFEKR 873
+ +P + P++ + R
Sbjct: 771 LDLSQPLEQYSPSYPDTR 788
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform c
precursor [Homo sapiens]
Length = 822
Score = 166 bits (421), Expect = 9e-41
Identities = 114/313 (36%), Positives = 163/313 (52%), Gaps = 41/313 (13%)
Query: 857 SEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCR-YD--PEGDNTGEQVAVKSLKPE 913
S+ KP T V H ++ + R+LGEG FGKV L Y+ PE D VAVK+LK +
Sbjct: 522 SQLKPDTFVQ--HIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKI--LVAVKTLK-D 576
Query: 914 SGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKN-- 971
+ N D +E E+L NL HE+IVK+ G+C E G+ + ++ E++ G L ++L +
Sbjct: 577 ASDNARKDFHREAELLTNLQHEHIVKFYGVCVE--GDPLIMVFEYMKHGDLNKFLRAHGP 634
Query: 972 ----------KNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD 1021
++ Q L A QI GM YL S+ +VHRDLA RN LV VKIGD
Sbjct: 635 DAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGD 694
Query: 1022 FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSD 1081
FG+++ + + +YY V P+ W PE +M KF SDVWS GV L E+ TY
Sbjct: 695 FGMSRDVYS-TDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY---G 750
Query: 1082 SSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTS 1141
P Q++ ++ + +G+ L P CP EVY+LM CW+ +P R +
Sbjct: 751 KQPWY-----------QLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKN 799
Query: 1142 FQNLIEGFEALLK 1154
I+G LL+
Sbjct: 800 ----IKGIHTLLQ 808
Score = 85.5 bits (210), Expect = 3e-16
Identities = 73/262 (27%), Positives = 117/262 (44%), Gaps = 30/262 (11%)
Query: 613 EEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEG 672
E+ KI V +K L + + F A ++ + H+HIV YGVCV IMV E+++
Sbjct: 563 EQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKH 622
Query: 673 GPLDLFM--HRKSDV----------LTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL 720
G L+ F+ H V LT +A+Q+A+ + YL + VH ++ T+N
Sbjct: 623 GDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNC 682
Query: 721 LLAREGIDSECGPFIKLSDPGIPITVLSRQ------ECIERIPWIAPECVEDSKNLSVAA 774
L+ + +K+ D G+ V S + I W+ PE + K + +
Sbjct: 683 LVGENLL-------VKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK-FTTES 734
Query: 775 DKWSFGTTLWEICYNGEIP---LKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYD 831
D WS G LWEI G+ P L + +IE RP T +E+ +LM C +
Sbjct: 735 DVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRT-CPQEVYELMLGCWQRE 793
Query: 832 PNQRPFFRAIMRDINKLEEQNP 853
P+ R + I + L + +P
Sbjct: 794 PHMRKNIKGIHTLLQNLAKASP 815
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform a
precursor [Homo sapiens]
Length = 838
Score = 166 bits (421), Expect = 9e-41
Identities = 114/313 (36%), Positives = 163/313 (52%), Gaps = 41/313 (13%)
Query: 857 SEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCR-YD--PEGDNTGEQVAVKSLKPE 913
S+ KP T V H ++ + R+LGEG FGKV L Y+ PE D VAVK+LK +
Sbjct: 538 SQLKPDTFVQ--HIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKI--LVAVKTLK-D 592
Query: 914 SGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKN-- 971
+ N D +E E+L NL HE+IVK+ G+C E G+ + ++ E++ G L ++L +
Sbjct: 593 ASDNARKDFHREAELLTNLQHEHIVKFYGVCVE--GDPLIMVFEYMKHGDLNKFLRAHGP 650
Query: 972 ----------KNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD 1021
++ Q L A QI GM YL S+ +VHRDLA RN LV VKIGD
Sbjct: 651 DAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGD 710
Query: 1022 FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSD 1081
FG+++ + + +YY V P+ W PE +M KF SDVWS GV L E+ TY
Sbjct: 711 FGMSRDVYS-TDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY---G 766
Query: 1082 SSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTS 1141
P Q++ ++ + +G+ L P CP EVY+LM CW+ +P R +
Sbjct: 767 KQPWY-----------QLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKN 815
Query: 1142 FQNLIEGFEALLK 1154
I+G LL+
Sbjct: 816 ----IKGIHTLLQ 824
Score = 85.5 bits (210), Expect = 3e-16
Identities = 73/262 (27%), Positives = 117/262 (44%), Gaps = 30/262 (11%)
Query: 613 EEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEG 672
E+ KI V +K L + + F A ++ + H+HIV YGVCV IMV E+++
Sbjct: 579 EQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKH 638
Query: 673 GPLDLFM--HRKSDV----------LTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL 720
G L+ F+ H V LT +A+Q+A+ + YL + VH ++ T+N
Sbjct: 639 GDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNC 698
Query: 721 LLAREGIDSECGPFIKLSDPGIPITVLSRQ------ECIERIPWIAPECVEDSKNLSVAA 774
L+ + +K+ D G+ V S + I W+ PE + K + +
Sbjct: 699 LVGENLL-------VKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK-FTTES 750
Query: 775 DKWSFGTTLWEICYNGEIP---LKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYD 831
D WS G LWEI G+ P L + +IE RP T +E+ +LM C +
Sbjct: 751 DVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRT-CPQEVYELMLGCWQRE 809
Query: 832 PNQRPFFRAIMRDINKLEEQNP 853
P+ R + I + L + +P
Sbjct: 810 PHMRKNIKGIHTLLQNLAKASP 831
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,209,130
Number of Sequences: 37866
Number of extensions: 2092180
Number of successful extensions: 10081
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 576
Number of HSP's successfully gapped in prelim test: 245
Number of HSP's that attempted gapping in prelim test: 6698
Number of HSP's gapped (non-prelim): 1764
length of query: 1154
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1041
effective length of database: 13,968,660
effective search space: 14541375060
effective search space used: 14541375060
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.