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Search of human proteins with 100913204
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|100913204 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
isoform 2 [Homo sapiens]
(856 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|100913204 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 iso... 1682 0.0
gi|100913202 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 iso... 1659 0.0
gi|212549538 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12 [Ho... 1621 0.0
gi|132566527 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 iso... 1492 0.0
gi|239755744 PREDICTED: similar to Putative ATP-dependent RNA he... 338 2e-92
gi|239755742 PREDICTED: similar to DEAD/H (Asp-Glu-Ala-Asp/His) ... 317 3e-86
gi|14042978 BRCA1 interacting protein C-terminal helicase 1 [Hom... 211 2e-54
gi|91984775 regulator of telomere elongation helicase 1 isoform ... 187 5e-47
gi|7706541 regulator of telomere elongation helicase 1 isoform 1... 187 5e-47
gi|15834617 excision repair cross-complementing rodent repair de... 113 9e-25
gi|195947407 excision repair cross-complementing rodent repair d... 67 5e-11
gi|239743668 PREDICTED: hypothetical protein XP_002342944 [Homo ... 59 1e-08
gi|239745348 PREDICTED: hypothetical protein XP_002343431 [Homo ... 59 3e-08
gi|239740967 PREDICTED: hypothetical protein XP_002342051 [Homo ... 59 3e-08
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 52 3e-06
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 52 3e-06
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 52 3e-06
gi|119120918 coiled-coil domain containing 64 [Homo sapiens] 51 5e-06
gi|148746195 trichohyalin [Homo sapiens] 50 7e-06
gi|22758136 MAP7 domain containing 2 [Homo sapiens] 50 9e-06
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 49 2e-05
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 49 2e-05
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 49 3e-05
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 49 3e-05
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 49 3e-05
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 49 3e-05
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 49 3e-05
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 49 3e-05
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 49 3e-05
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 49 3e-05
>gi|100913204 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
isoform 2 [Homo sapiens]
Length = 856
Score = 1682 bits (4356), Expect = 0.0
Identities = 856/856 (100%), Positives = 856/856 (100%)
Query: 1 MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS
Sbjct: 1 MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
Query: 61 WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK
Sbjct: 61 WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET
Sbjct: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
Query: 181 GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA 240
GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA
Sbjct: 181 GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA 240
Query: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE 300
QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE
Sbjct: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE 300
Query: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP
Sbjct: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
Query: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS 420
AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS
Sbjct: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS 420
Query: 421 QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND 480
QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND
Sbjct: 421 QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND 480
Query: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR
Sbjct: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
Query: 541 TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL
Sbjct: 541 TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
Query: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP
Sbjct: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
Query: 661 LVICSGISNQPLEFTFQKRELPQMIFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGAL 720
LVICSGISNQPLEFTFQKRELPQMIFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGAL
Sbjct: 661 LVICSGISNQPLEFTFQKRELPQMIFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGAL 720
Query: 721 LLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGK 780
LLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGK
Sbjct: 721 LLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGK 780
Query: 781 ALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGP 840
ALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGP
Sbjct: 781 ALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGP 840
Query: 841 AIAAVQKFHREKSASS 856
AIAAVQKFHREKSASS
Sbjct: 841 AIAAVQKFHREKSASS 856
>gi|100913202 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
isoform 1 [Homo sapiens]
Length = 906
Score = 1659 bits (4295), Expect = 0.0
Identities = 856/906 (94%), Positives = 856/906 (94%), Gaps = 50/906 (5%)
Query: 1 MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS
Sbjct: 1 MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
Query: 61 WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK
Sbjct: 61 WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET
Sbjct: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
Query: 181 GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA 240
GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA
Sbjct: 181 GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA 240
Query: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE 300
QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE
Sbjct: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE 300
Query: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP
Sbjct: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
Query: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS 420
AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS
Sbjct: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS 420
Query: 421 QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND 480
QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND
Sbjct: 421 QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND 480
Query: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR
Sbjct: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
Query: 541 TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL
Sbjct: 541 TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
Query: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP
Sbjct: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
Query: 661 LVICSGISNQPLEFTFQKRELPQM------------------------------------ 684
LVICSGISNQPLEFTFQKRELPQM
Sbjct: 661 LVICSGISNQPLEFTFQKRELPQMMDEVGRILCNLCGVVPGGVVCFFPSYEYLRQVHAHW 720
Query: 685 --------------IFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMS 730
IFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMS
Sbjct: 721 EKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMS 780
Query: 731 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKA 790
EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKA
Sbjct: 781 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKA 840
Query: 791 VNQSIGRAIRHQKDFASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 850
VNQSIGRAIRHQKDFASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR
Sbjct: 841 VNQSIGRAIRHQKDFASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 900
Query: 851 EKSASS 856
EKSASS
Sbjct: 901 EKSASS 906
>gi|212549538 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12 [Homo
sapiens]
Length = 906
Score = 1621 bits (4197), Expect = 0.0
Identities = 835/906 (92%), Positives = 847/906 (93%), Gaps = 50/906 (5%)
Query: 1 MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS
Sbjct: 1 MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
Query: 61 WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK
Sbjct: 61 WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
KEERDLV+RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET
Sbjct: 121 KEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
Query: 181 GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA 240
GPEAER EQLESGEEELVLAEYESDEEKKVAS VDEDEDDLEEEHITKIY+CSRTHSQLA
Sbjct: 181 GPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLA 240
Query: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE 300
QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDV+SLGSVQLIN+RCVDMQRSRHEKKKGAE
Sbjct: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKGAE 300
Query: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP
Sbjct: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
Query: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS 420
AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDT T MHSVEVSGSQLCQAHS
Sbjct: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTTTSMHSVEVSGSQLCQAHS 420
Query: 421 QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND 480
QLLQY+ERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTG ELKTIND
Sbjct: 421 QLLQYMERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGMELKTIND 480
Query: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR
Sbjct: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
Query: 541 TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
TTEALAAPADESQAS +PASPLMHI+GFLAALTTANQDGRVILSRQGSLSQSTLKFLLL
Sbjct: 541 TTEALAAPADESQASVPQPASPLMHIEGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
Query: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
NPAVHFAQVVKECRAVVIAGGTMQPVS+FRQQLLACAGVEAERVVEFSCGHVIPPDNILP
Sbjct: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSNFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
Query: 661 LVICSGISNQPLEFTFQKRELPQM------------------------------------ 684
LVICSG+SNQPLEFTFQKR+LPQM
Sbjct: 661 LVICSGVSNQPLEFTFQKRDLPQMMDEVGRILCNLCGVVSGGVVCFFPSYEYLRQVHAHW 720
Query: 685 --------------IFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMS 730
IFQEPKSAHQVEQVLLAYSRC+QACGQERG VTGALLLSVVGGKMS
Sbjct: 721 EKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCLQACGQERGPVTGALLLSVVGGKMS 780
Query: 731 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKA 790
EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQA PGKALVENLCMKA
Sbjct: 781 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAHPGKALVENLCMKA 840
Query: 791 VNQSIGRAIRHQKDFASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 850
VNQSIGRAIRHQKDFAS+VLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR
Sbjct: 841 VNQSIGRAIRHQKDFASIVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 900
Query: 851 EKSASS 856
EKSASS
Sbjct: 901 EKSASS 906
>gi|132566527 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
isoform 3 [Homo sapiens]
Length = 970
Score = 1492 bits (3863), Expect = 0.0
Identities = 772/829 (93%), Positives = 772/829 (93%), Gaps = 50/829 (6%)
Query: 1 MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS
Sbjct: 1 MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
Query: 61 WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK
Sbjct: 61 WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET
Sbjct: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
Query: 181 GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA 240
GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA
Sbjct: 181 GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA 240
Query: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE 300
QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE
Sbjct: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE 300
Query: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP
Sbjct: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
Query: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS 420
AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS
Sbjct: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS 420
Query: 421 QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND 480
QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND
Sbjct: 421 QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND 480
Query: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR
Sbjct: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
Query: 541 TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL
Sbjct: 541 TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
Query: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP
Sbjct: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
Query: 661 LVICSGISNQPLEFTFQKRELPQM------------------------------------ 684
LVICSGISNQPLEFTFQKRELPQM
Sbjct: 661 LVICSGISNQPLEFTFQKRELPQMMDEVGRILCNLCGVVPGGVVCFFPSYEYLRQVHAHW 720
Query: 685 --------------IFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMS 730
IFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMS
Sbjct: 721 EKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMS 780
Query: 731 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPG 779
EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTL PG G
Sbjct: 781 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLSPRPGTPREG 829
>gi|239755744 PREDICTED: similar to Putative ATP-dependent RNA
helicase DDX11-like protein [Homo sapiens]
Length = 223
Score = 338 bits (866), Expect = 2e-92
Identities = 170/172 (98%), Positives = 171/172 (99%)
Query: 685 IFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMSEGINFSDNLGRCVV 744
IFQEPKSAHQVEQVLLAYSRCIQACGQERGQVT ALLLSVVGGKMSEGINFSDNLGRCVV
Sbjct: 52 IFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTEALLLSVVGGKMSEGINFSDNLGRCVV 111
Query: 745 MVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKAVNQSIGRAIRHQKD 804
MVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKAVNQSIGRAIRHQKD
Sbjct: 112 MVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKAVNQSIGRAIRHQKD 171
Query: 805 FASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHREKSASS 856
FAS+VLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHREKSASS
Sbjct: 172 FASIVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHREKSASS 223
>gi|239755742 PREDICTED: similar to DEAD/H (Asp-Glu-Ala-Asp/His) box
polypeptide 11 (CHL1-like helicase homolog, S.
cerevisiae) [Homo sapiens]
Length = 282
Score = 317 bits (812), Expect = 3e-86
Identities = 162/173 (93%), Positives = 163/173 (94%)
Query: 45 PTGTGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT 104
P GKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT
Sbjct: 39 PAKKGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT 98
Query: 105 PRPAGEPAWVTQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEE 164
PRPAGEPAWVTQFVQKKEERDLV+RLK EQARRKQREERLQQLQHRVQLKYAAKRLRQEE
Sbjct: 99 PRPAGEPAWVTQFVQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEE 158
Query: 165 EERENLLRLSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDED 217
EE ENLLRLSREMLETGPEAE LEQLESGEEELVLAEYESDEEKKVAS D
Sbjct: 159 EETENLLRLSREMLETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGAPSD 211
>gi|14042978 BRCA1 interacting protein C-terminal helicase 1 [Homo
sapiens]
Length = 1249
Score = 211 bits (538), Expect = 2e-54
Identities = 218/937 (23%), Positives = 407/937 (43%), Gaps = 152/937 (16%)
Query: 8 VGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQ 67
+G + FP+ Y Q M + R L + + + ESPTG+GKSL+L+C AL+W +
Sbjct: 10 IGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSG 69
Query: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGA--------AGTPR-------PAGEPA 112
K +E + ++ + L +C GT R P E
Sbjct: 70 KPADEG----------VSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPSTPPSERN 119
Query: 113 WVTQFVQKKEERD-LVDRLKAEQARRKQREER--LQQLQHRVQLKYAAKRLRQEEEEREN 169
+ Q E+ L +L A++ R+E Q + R++ +++R+
Sbjct: 120 GTSSTCQDSPEKTTLAAKLSAKKQASIYRDENDDFQVEKKRIRPLETTQQIRKRHCFGTE 179
Query: 170 LLRLSREMLETGPEAER---LEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEH- 225
+ L ++ ++G + LE++ S + E + ++++H
Sbjct: 180 VHNLDAKV-DSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHT 238
Query: 226 ----ITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
I KIY+ +RTH Q+AQ E++++ + V + L SR + CV+ +V +G+
Sbjct: 239 GKSKIPKIYFGTRTHKQIAQITRELRRTAYS-GVPMTILSSRDHTCVHPEV--VGNFNR- 294
Query: 282 NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYN-----HEQMGLLRDEALAEVKD 336
N++C+++ ++ K +C FY+ +Q L + + + D
Sbjct: 295 NEKCMELLDGKNGK------------------SCYFYHGVHKISDQHTLQTFQGMCKAWD 336
Query: 337 MEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAH 396
+E+L++LGK+ +ACPYY +R I A ++ PY LL A R++ + L++QVVI+DEAH
Sbjct: 337 IEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAH 396
Query: 397 NLIDTITGMHSVEVSGSQLCQAHSQLLQYVERYGKRLKAKNLMYLKQI-LYLLEKFVAVL 455
N+ D S V+ QL A +L V ++ K+ L+ + L+ A
Sbjct: 397 NIEDCARESASYSVTEVQLRFARDELDSMV---NNNIRKKDHEPLRAVCCSLINWLEANA 453
Query: 456 GGNIKQNPNTQSLSQTGTE-LKTINDFLFQSQIDNINLFKVQRYCEKSMISRKLFGFTE- 513
++++ + +G E L T++ + I +K ++G E
Sbjct: 454 EYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEA 513
Query: 514 RYGAVFSSREQPKLAGFQQFLQSLQPRTTEALAAPADESQASTLRPASPLMHIQGFLAAL 573
R V S+ Q L G L L + + AD+ + + + + +
Sbjct: 514 REVPVISASTQIMLKGLFMVLDYLFRQNSRF----ADDYKIA-------IQQTYSWTNQI 562
Query: 574 TTANQDGRVILSRQGSLSQS-----TLKFLLLNPAVHFAQVVKECRAVVIAGGTMQPVSD 628
++++G ++L + S+ L F LNPAV F+ + + + +V+ GT+ P+
Sbjct: 563 DISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKS 622
Query: 629 FRQQLLACAGVEAERVVEFSCGHVIPPDNILPLVICSGISNQPLEFTFQKR--------- 679
F +L GV ++ H+I + I SG + L TFQ
Sbjct: 623 FSSEL----GVTF--TIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEV 676
Query: 680 -----------------------------------------ELPQMIFQEPKSAHQV--E 696
EL + + EP+ + +
Sbjct: 677 GALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFD 736
Query: 697 QVLLAYSRCIQACGQERGQVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSA 756
++L Y I + +G+ GALL++V GK+SEG++FSD+ R V+ +G+PFPN++
Sbjct: 737 ELLQVYYDAI----KYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDL 792
Query: 757 ELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRYA 816
+++ K Y D + G PG+ E +A+NQ++GR IRH+ D+ +++L+D R+
Sbjct: 793 QVELKRQYNDHH-SKLRGLL-PGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFR 850
Query: 817 RPP--VLAKLPAWIRARVEVKATFGPAIAAVQKFHRE 851
P ++ L W+R +++ +TF A+ ++ +F ++
Sbjct: 851 NNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKK 887
>gi|91984775 regulator of telomere elongation helicase 1 isoform 2
[Homo sapiens]
Length = 1300
Score = 187 bits (474), Expect = 5e-47
Identities = 178/695 (25%), Positives = 298/695 (42%), Gaps = 120/695 (17%)
Query: 226 ITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC 285
I KI Y SRTHSQL Q ++E++ + + V + LGSR+ LC++ +VK S L C
Sbjct: 106 IPKIIYASRTHSQLTQVINELRNTSYRPKVCV--LGSREQLCIHPEVKKQESNHLQIHLC 163
Query: 286 VDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGK 345
R++ +C FYN+ + L E + + D+E L+ G
Sbjct: 164 ---------------------RKKVASRSCHFYNNVEEKSLEQELASPILDIEDLVKSGS 202
Query: 346 EARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNL------- 398
+ R CPYY SR A ++ +PY LL A +R+A I L+ VVI DEAHN+
Sbjct: 203 KHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDLKGTVVIFDEAHNVEKMCEES 262
Query: 399 -------------IDTITGMHSVEVSGSQLCQAHSQLLQYVERYGKRLKAKNLMYLKQIL 445
+D I + + +Q + H + G ++ +++ LK IL
Sbjct: 263 ASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFSADSPSPGLNMELEDIAKLKMIL 322
Query: 446 YLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTINDFLFQSQIDNINLFKVQRYCEKSMIS 505
LE + ++ + +++ G+ ++F+ + F+ + C +
Sbjct: 323 LRLEGAIDA----VELPGDDSGVTKPGS-------YIFELFAEAQITFQTKG-CILDSLD 370
Query: 506 RKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPRTTEALAAPADESQASTLRPASPLMH 565
+ + R G ++ KLA Q + S+ P +P + L+ S +H
Sbjct: 371 QIIQHLAGRAGVFTNTAGLQKLADIIQIVFSVDPSE----GSPGSPAGLGALQ--SYKVH 424
Query: 566 IQGFLAALTTANQD---GRVILSRQGSLSQSTLKFLLLNPAVHFAQVVKE-CRAVVIAGG 621
I TA + ++G + L + +P ++V++ R++++ G
Sbjct: 425 IHPDAGHRRTAQRSDAWSTTAARKRGKV----LSYWCFSPGHSMHELVRQGVRSLILTSG 480
Query: 622 TMQPVSDF--RQQLLACAGVEAERVVE-------------------------FS------ 648
T+ PVS F Q+ +E +++ FS
Sbjct: 481 TLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSS 540
Query: 649 ----CGHV--IPPDNILPLVICSGISNQPLEF-----TFQKRELPQMIFQEPKSAHQVEQ 697
G++ + P +L + + LEF +K E + +F EP+S +
Sbjct: 541 LGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRSKGSFSE 600
Query: 698 VLLAYSRCIQACGQERGQVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAE 757
+ AY + A G TGA L+V GK SEG++FSD GR V++ G+P+P
Sbjct: 601 TISAYYARVAAPGS-----TGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPR 655
Query: 758 LQEKMAYLDQTLPR--APGQAPPGKALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRY 815
+ KM +LD+ + A GQ G+ +AVNQ+IGR IRH++D+ +V L D R+
Sbjct: 656 VVLKMQFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRF 715
Query: 816 ARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 850
A A+LP+W+R V V FG I V +F R
Sbjct: 716 AFADARAQLPSWVRPHVRVYDNFGHVIRDVAQFFR 750
Score = 57.4 bits (137), Expect = 6e-08
Identities = 35/94 (37%), Positives = 49/94 (52%), Gaps = 10/94 (10%)
Query: 15 FPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSW---LRDFEQKKRE 71
FPF PY Q+++M ++ L+ GI ESPTGTGK+L L+C L+W LRD +
Sbjct: 13 FPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWREHLRDGISAR-- 70
Query: 72 EEARLLETGTGPLHDEKDESLCLSSSCEGAAGTP 105
++ E G L D +L + AAG P
Sbjct: 71 ---KIAERAQGELF--PDRALSSWGNAAAAAGDP 99
>gi|7706541 regulator of telomere elongation helicase 1 isoform 1
[Homo sapiens]
Length = 1219
Score = 187 bits (474), Expect = 5e-47
Identities = 178/695 (25%), Positives = 298/695 (42%), Gaps = 120/695 (17%)
Query: 226 ITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC 285
I KI Y SRTHSQL Q ++E++ + + V + LGSR+ LC++ +VK S L C
Sbjct: 106 IPKIIYASRTHSQLTQVINELRNTSYRPKVCV--LGSREQLCIHPEVKKQESNHLQIHLC 163
Query: 286 VDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGK 345
R++ +C FYN+ + L E + + D+E L+ G
Sbjct: 164 ---------------------RKKVASRSCHFYNNVEEKSLEQELASPILDIEDLVKSGS 202
Query: 346 EARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNL------- 398
+ R CPYY SR A ++ +PY LL A +R+A I L+ VVI DEAHN+
Sbjct: 203 KHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDLKGTVVIFDEAHNVEKMCEES 262
Query: 399 -------------IDTITGMHSVEVSGSQLCQAHSQLLQYVERYGKRLKAKNLMYLKQIL 445
+D I + + +Q + H + G ++ +++ LK IL
Sbjct: 263 ASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFSADSPSPGLNMELEDIAKLKMIL 322
Query: 446 YLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTINDFLFQSQIDNINLFKVQRYCEKSMIS 505
LE + ++ + +++ G+ ++F+ + F+ + C +
Sbjct: 323 LRLEGAIDA----VELPGDDSGVTKPGS-------YIFELFAEAQITFQTKG-CILDSLD 370
Query: 506 RKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPRTTEALAAPADESQASTLRPASPLMH 565
+ + R G ++ KLA Q + S+ P +P + L+ S +H
Sbjct: 371 QIIQHLAGRAGVFTNTAGLQKLADIIQIVFSVDPSE----GSPGSPAGLGALQ--SYKVH 424
Query: 566 IQGFLAALTTANQD---GRVILSRQGSLSQSTLKFLLLNPAVHFAQVVKE-CRAVVIAGG 621
I TA + ++G + L + +P ++V++ R++++ G
Sbjct: 425 IHPDAGHRRTAQRSDAWSTTAARKRGKV----LSYWCFSPGHSMHELVRQGVRSLILTSG 480
Query: 622 TMQPVSDF--RQQLLACAGVEAERVVE-------------------------FS------ 648
T+ PVS F Q+ +E +++ FS
Sbjct: 481 TLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSS 540
Query: 649 ----CGHV--IPPDNILPLVICSGISNQPLEF-----TFQKRELPQMIFQEPKSAHQVEQ 697
G++ + P +L + + LEF +K E + +F EP+S +
Sbjct: 541 LGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRSKGSFSE 600
Query: 698 VLLAYSRCIQACGQERGQVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAE 757
+ AY + A G TGA L+V GK SEG++FSD GR V++ G+P+P
Sbjct: 601 TISAYYARVAAPGS-----TGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPR 655
Query: 758 LQEKMAYLDQTLPR--APGQAPPGKALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRY 815
+ KM +LD+ + A GQ G+ +AVNQ+IGR IRH++D+ +V L D R+
Sbjct: 656 VVLKMQFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRF 715
Query: 816 ARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 850
A A+LP+W+R V V FG I V +F R
Sbjct: 716 AFADARAQLPSWVRPHVRVYDNFGHVIRDVAQFFR 750
Score = 57.4 bits (137), Expect = 6e-08
Identities = 35/94 (37%), Positives = 49/94 (52%), Gaps = 10/94 (10%)
Query: 15 FPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSW---LRDFEQKKRE 71
FPF PY Q+++M ++ L+ GI ESPTGTGK+L L+C L+W LRD +
Sbjct: 13 FPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWREHLRDGISAR-- 70
Query: 72 EEARLLETGTGPLHDEKDESLCLSSSCEGAAGTP 105
++ E G L D +L + AAG P
Sbjct: 71 ---KIAERAQGELF--PDRALSSWGNAAAAAGDP 99
>gi|15834617 excision repair cross-complementing rodent repair
deficiency, complementation group 2 protein isoform 1
[Homo sapiens]
Length = 760
Score = 113 bits (282), Expect = 9e-25
Identities = 161/715 (22%), Positives = 284/715 (39%), Gaps = 139/715 (19%)
Query: 226 ITKIYYCSRTHSQLAQFVHEVKK------SPFGKDVRLV--SLGSRQNLCVNEDVKSLGS 277
+TK+ YCSRT ++ + + E++K G+ + + +L SR+NLC++ +V L
Sbjct: 67 VTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRF 126
Query: 278 VQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDM 337
+ ++ +C + S + + P C FY A + ++
Sbjct: 127 GKDVDGKCHSLTASYVRAQYQHDTSLPH---------CRFYEEFDAHGREVPLPAGIYNL 177
Query: 338 EQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRL-QDQVVIIDEAH 396
+ L ALG+ CPY+ +R +I A +VV Y LL L + VV+ DEAH
Sbjct: 178 DDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAH 237
Query: 397 NLIDTITGMHSVEVSGSQL--CQAHSQLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAV 454
N+ + SV ++ L CQ + L+ +++ R+K + L+ +++ +
Sbjct: 238 NIDNVCIDSMSVNLTRRTLDRCQGN---LETLQKTVLRIKETDEQRLR------DEYRRL 288
Query: 455 LGGNIKQNPNTQSLSQTGTELKTINDFLFQSQIDNINLFKVQRYCEKSMISRKLFGFTER 514
+ G + + ++ + + + D + Q + ++ + + + R L R
Sbjct: 289 VEGLREASAARETDAHLANPV--LPDEVLQEAVPG-SIRTAEHFL--GFLRRLLEYVKWR 343
Query: 515 YGAVFSSREQPKLAGFQQFLQSLQPRT----------TEALAAPADESQASTLRPASPLM 564
+E P FL L R E L + + + L SPL
Sbjct: 344 LRVQHVVQESPPA-----FLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLT 398
Query: 565 HIQGFLAALTTANQDGRVILS----RQGSLSQSTLKFLLLNPAVHFAQVVKECRAVVIAG 620
+ F ++T + +I+ R +++ L F ++ ++ V + ++V+I
Sbjct: 399 LLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITS 458
Query: 621 GTMQPVS------DFRQQLLACAGVEAERVVEFSCGHVIPPDNILPLVICSGISNQPLEF 674
GT+ P+ DF +A + RV + P++I G +
Sbjct: 459 GTLSPLDIYPKILDFHPVTMATFTMTLARVC------------LCPMIIGRGNDQVAISS 506
Query: 675 TFQKRE------------------LPQMI--------FQEPKSAHQVEQVLL-------- 700
F+ RE +P I + E A EQ +L
Sbjct: 507 KFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKL 566
Query: 701 -------------AYSRCIQACGQERGQVTGALLLSVVGGKMSEGINFSDNLGRCVVMVG 747
A + +AC RG A+LLSV GK+SEGI+F + GR V+M G
Sbjct: 567 LFIETQDGAETSVALEKYQEACENGRG----AILLSVARGKVSEGIDFVHHYGRAVIMFG 622
Query: 748 MPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKAVNQSIGRAIRHQKDFAS 807
+P+ +S L+ ++ YL R Q L + M+ Q +GRAIR + D+
Sbjct: 623 VPYVYTQSRILKARLEYL-----RDQFQIRENDFLTFD-AMRHAAQCVGRAIRGKTDYGL 676
Query: 808 VVLLDQRYARPPVLAKLPAWIR-----ARVEVKATFGPAIA------AVQKFHRE 851
+V D+R+AR KLP WI+ A + + G +A Q FHRE
Sbjct: 677 MVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHRE 731
Score = 41.6 bits (96), Expect = 0.003
Identities = 20/55 (36%), Positives = 35/55 (63%), Gaps = 1/55 (1%)
Query: 11 IHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDF 65
++FP+ + Y Q +M EL R L+A G+ E P+GTGK++SL+ +++ R +
Sbjct: 10 VYFPYDYI-YPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAY 63
>gi|195947407 excision repair cross-complementing rodent repair
deficiency, complementation group 2 protein isoform 2
[Homo sapiens]
Length = 405
Score = 67.4 bits (163), Expect = 5e-11
Identities = 55/210 (26%), Positives = 95/210 (45%), Gaps = 20/210 (9%)
Query: 226 ITKIYYCSRTHSQLAQFVHEVKK------SPFGKDVRLV--SLGSRQNLCVNEDVKSLGS 277
+TK+ YCSRT ++ + + E++K G+ + + +L SR+NLC++ +V L
Sbjct: 43 VTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRF 102
Query: 278 VQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDM 337
+ ++ +C + S + + P C FY A + ++
Sbjct: 103 GKDVDGKCHSLTASYVRAQYQHDTSLPH---------CRFYEEFDAHGREVPLPAGIYNL 153
Query: 338 EQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRL-QDQVVIIDEAH 396
+ L ALG+ CPY+ +R +I A +VV Y LL L + VV+ DEAH
Sbjct: 154 DDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAH 213
Query: 397 NLIDTITGMHSVEVSGSQL--CQAHSQLLQ 424
N+ + SV ++ L CQ + + LQ
Sbjct: 214 NIDNVCIDSMSVNLTRRTLDRCQGNLETLQ 243
Score = 34.7 bits (78), Expect = 0.39
Identities = 16/39 (41%), Positives = 26/39 (66%)
Query: 27 MAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDF 65
M EL R L+A G+ E P+GTGK++SL+ +++ R +
Sbjct: 1 MRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAY 39
>gi|239743668 PREDICTED: hypothetical protein XP_002342944 [Homo
sapiens]
Length = 133
Score = 59.3 bits (142), Expect = 1e-08
Identities = 33/54 (61%), Positives = 35/54 (64%), Gaps = 6/54 (11%)
Query: 729 MSEGINFSDNLG------RCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQA 776
MSE INFSDNLG RCVVM GMPFP+IRS ELQ+ A LD L P A
Sbjct: 1 MSESINFSDNLGQLLSPPRCVVMPGMPFPSIRSPELQKTTADLDHNLVSVPSVA 54
>gi|239745348 PREDICTED: hypothetical protein XP_002343431 [Homo
sapiens]
Length = 133
Score = 58.5 bits (140), Expect = 3e-08
Identities = 33/54 (61%), Positives = 35/54 (64%), Gaps = 6/54 (11%)
Query: 729 MSEGINFSDNLG------RCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQA 776
MSE INFS NLG RCVVM GMPFP+IRS ELQ+ A LD TL P A
Sbjct: 1 MSESINFSHNLGQLLSPPRCVVMPGMPFPSIRSPELQKTTADLDHTLVSVPSVA 54
>gi|239740967 PREDICTED: hypothetical protein XP_002342051 [Homo
sapiens]
Length = 133
Score = 58.5 bits (140), Expect = 3e-08
Identities = 33/54 (61%), Positives = 35/54 (64%), Gaps = 6/54 (11%)
Query: 729 MSEGINFSDNLG------RCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQA 776
MSE INFS NLG RCVVM GMPFP+IRS ELQ+ A LD TL P A
Sbjct: 1 MSESINFSHNLGQLLSPPRCVVMPGMPFPSIRSPELQKTTADLDHTLVSVPSVA 54
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 51.6 bits (122), Expect = 3e-06
Identities = 60/228 (26%), Positives = 103/228 (45%), Gaps = 40/228 (17%)
Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAK------RLRQEEEERENLLRLS 174
KE + L DRL ++ + EE+++ L ++++LKY A RLR+EE+ R+ L +L
Sbjct: 1024 KERKLLEDRLAEFSSQAAEEEEKVKSL-NKLRLKYEATIADMEDRLRKEEKGRQELEKLK 1082
Query: 175 R-----------EMLETGPEAERLE-QLESGEEELVLAEYESDEE-----------KKVA 211
R +M+E AE L QL EEEL A +++E ++
Sbjct: 1083 RRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQ 1142
Query: 212 SRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLC---- 267
+ + E ++DLE E + + ++ Q E++ + L S ++Q L
Sbjct: 1143 AALAEAQEDLESERVAR----TKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKRE 1198
Query: 268 --VNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQA 313
V E K+L I++ V R RH + G E+ ++ R+ K A
Sbjct: 1199 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGA 1246
Score = 37.0 bits (84), Expect = 0.078
Identities = 62/282 (21%), Positives = 104/282 (36%), Gaps = 70/282 (24%)
Query: 128 DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
D + +A+ Q+ + LQQ R ++ R+ Q EEER L R E EAE
Sbjct: 876 DEVLQARAQELQKVQELQQQSAR-EVGELQGRVAQLEEERARLAEQLRAEAELCAEAEET 934
Query: 188 E---QLESGEEELVLAEYES-------------DEEKKVASRVDEDEDDLEEEHITKIYY 231
E ELV++E E+ E+K++ + E E LE E
Sbjct: 935 RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE------ 988
Query: 232 CSRTHSQLAQFVHEVKKSPFGKDVRLVS-----LGSRQNLCVN-------------EDVK 273
+R QL + E K F +D+ L+ L + L + E VK
Sbjct: 989 GARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVK 1048
Query: 274 SLGSVQL-----------------------------INDRCVDMQRSRHEKKKGAEEEKP 304
SL ++L ++ ++Q E+++ AEE +
Sbjct: 1049 SLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1108
Query: 305 KRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKE 346
+ R+E++ E G R + L +++ + LA +E
Sbjct: 1109 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQE 1150
Score = 33.9 bits (76), Expect = 0.66
Identities = 78/334 (23%), Positives = 134/334 (40%), Gaps = 42/334 (12%)
Query: 62 LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGE----PAWVTQF 117
L D ++ +EE L G+ E + + E AA R E A ++++
Sbjct: 1342 LHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEW 1401
Query: 118 VQKKEERDLVDRLKAEQARRKQRE-----ERLQQLQHRV-QLKYAAKRLRQEEEERENLL 171
+++EE E RR RE +RL + V +L+ +RL+QE ++ L
Sbjct: 1402 RRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL 1461
Query: 172 RLSREMLETGPEAER-LEQLESGEEELVL--------AEYESDEEKKVA---SRVDEDED 219
R+++ T + +R +QL + E+ VL AE E E + A +R E+E
Sbjct: 1462 EQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQ 1521
Query: 220 DLEEE-------HITKIYYCSRTHSQLAQFVHEVKKS-----PFGKDVRLVSLGSRQNLC 267
+ EE ++ + + + VHE++++ D+R L
Sbjct: 1522 EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELT 1581
Query: 268 VNEDVKSLGSVQLINDRCVDMQRSRHEKK-KGAEEEKPKRRRQ-EKQAACPFYNHEQMGL 325
ED K L + V +++HE+ +G +E +RRRQ KQ ++
Sbjct: 1582 AAEDAK------LRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERK 1635
Query: 326 LRDEALAEVKDMEQLLALGKEARACPYYGSRLAI 359
R A+A K +E L K A G A+
Sbjct: 1636 QRTLAVAARKKLEGELEELKAQMASAGQGKEEAV 1669
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 51.6 bits (122), Expect = 3e-06
Identities = 60/228 (26%), Positives = 103/228 (45%), Gaps = 40/228 (17%)
Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAK------RLRQEEEERENLLRLS 174
KE + L DRL ++ + EE+++ L ++++LKY A RLR+EE+ R+ L +L
Sbjct: 1016 KERKLLEDRLAEFSSQAAEEEEKVKSL-NKLRLKYEATIADMEDRLRKEEKGRQELEKLK 1074
Query: 175 R-----------EMLETGPEAERLE-QLESGEEELVLAEYESDEE-----------KKVA 211
R +M+E AE L QL EEEL A +++E ++
Sbjct: 1075 RRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQ 1134
Query: 212 SRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLC---- 267
+ + E ++DLE E + + ++ Q E++ + L S ++Q L
Sbjct: 1135 AALAEAQEDLESERVAR----TKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKRE 1190
Query: 268 --VNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQA 313
V E K+L I++ V R RH + G E+ ++ R+ K A
Sbjct: 1191 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGA 1238
Score = 37.0 bits (84), Expect = 0.078
Identities = 62/282 (21%), Positives = 104/282 (36%), Gaps = 70/282 (24%)
Query: 128 DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
D + +A+ Q+ + LQQ R ++ R+ Q EEER L R E EAE
Sbjct: 868 DEVLQARAQELQKVQELQQQSAR-EVGELQGRVAQLEEERARLAEQLRAEAELCAEAEET 926
Query: 188 E---QLESGEEELVLAEYES-------------DEEKKVASRVDEDEDDLEEEHITKIYY 231
E ELV++E E+ E+K++ + E E LE E
Sbjct: 927 RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE------ 980
Query: 232 CSRTHSQLAQFVHEVKKSPFGKDVRLVS-----LGSRQNLCVN-------------EDVK 273
+R QL + E K F +D+ L+ L + L + E VK
Sbjct: 981 GARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVK 1040
Query: 274 SLGSVQL-----------------------------INDRCVDMQRSRHEKKKGAEEEKP 304
SL ++L ++ ++Q E+++ AEE +
Sbjct: 1041 SLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1100
Query: 305 KRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKE 346
+ R+E++ E G R + L +++ + LA +E
Sbjct: 1101 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQE 1142
Score = 33.9 bits (76), Expect = 0.66
Identities = 78/334 (23%), Positives = 134/334 (40%), Gaps = 42/334 (12%)
Query: 62 LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGE----PAWVTQF 117
L D ++ +EE L G+ E + + E AA R E A ++++
Sbjct: 1334 LHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEW 1393
Query: 118 VQKKEERDLVDRLKAEQARRKQRE-----ERLQQLQHRV-QLKYAAKRLRQEEEERENLL 171
+++EE E RR RE +RL + V +L+ +RL+QE ++ L
Sbjct: 1394 RRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL 1453
Query: 172 RLSREMLETGPEAER-LEQLESGEEELVL--------AEYESDEEKKVA---SRVDEDED 219
R+++ T + +R +QL + E+ VL AE E E + A +R E+E
Sbjct: 1454 EQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQ 1513
Query: 220 DLEEE-------HITKIYYCSRTHSQLAQFVHEVKKS-----PFGKDVRLVSLGSRQNLC 267
+ EE ++ + + + VHE++++ D+R L
Sbjct: 1514 EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELT 1573
Query: 268 VNEDVKSLGSVQLINDRCVDMQRSRHEKK-KGAEEEKPKRRRQ-EKQAACPFYNHEQMGL 325
ED K L + V +++HE+ +G +E +RRRQ KQ ++
Sbjct: 1574 AAEDAK------LRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERK 1627
Query: 326 LRDEALAEVKDMEQLLALGKEARACPYYGSRLAI 359
R A+A K +E L K A G A+
Sbjct: 1628 QRTLAVAARKKLEGELEELKAQMASAGQGKEEAV 1661
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 51.6 bits (122), Expect = 3e-06
Identities = 60/228 (26%), Positives = 103/228 (45%), Gaps = 40/228 (17%)
Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAK------RLRQEEEERENLLRLS 174
KE + L DRL ++ + EE+++ L ++++LKY A RLR+EE+ R+ L +L
Sbjct: 1057 KERKLLEDRLAEFSSQAAEEEEKVKSL-NKLRLKYEATIADMEDRLRKEEKGRQELEKLK 1115
Query: 175 R-----------EMLETGPEAERLE-QLESGEEELVLAEYESDEE-----------KKVA 211
R +M+E AE L QL EEEL A +++E ++
Sbjct: 1116 RRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQ 1175
Query: 212 SRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLC---- 267
+ + E ++DLE E + + ++ Q E++ + L S ++Q L
Sbjct: 1176 AALAEAQEDLESERVAR----TKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKRE 1231
Query: 268 --VNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQA 313
V E K+L I++ V R RH + G E+ ++ R+ K A
Sbjct: 1232 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGA 1279
Score = 37.0 bits (84), Expect = 0.078
Identities = 62/282 (21%), Positives = 104/282 (36%), Gaps = 70/282 (24%)
Query: 128 DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
D + +A+ Q+ + LQQ R ++ R+ Q EEER L R E EAE
Sbjct: 909 DEVLQARAQELQKVQELQQQSAR-EVGELQGRVAQLEEERARLAEQLRAEAELCAEAEET 967
Query: 188 E---QLESGEEELVLAEYES-------------DEEKKVASRVDEDEDDLEEEHITKIYY 231
E ELV++E E+ E+K++ + E E LE E
Sbjct: 968 RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE------ 1021
Query: 232 CSRTHSQLAQFVHEVKKSPFGKDVRLVS-----LGSRQNLCVN-------------EDVK 273
+R QL + E K F +D+ L+ L + L + E VK
Sbjct: 1022 GARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVK 1081
Query: 274 SLGSVQL-----------------------------INDRCVDMQRSRHEKKKGAEEEKP 304
SL ++L ++ ++Q E+++ AEE +
Sbjct: 1082 SLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1141
Query: 305 KRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKE 346
+ R+E++ E G R + L +++ + LA +E
Sbjct: 1142 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQE 1183
Score = 33.9 bits (76), Expect = 0.66
Identities = 78/334 (23%), Positives = 134/334 (40%), Gaps = 42/334 (12%)
Query: 62 LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGE----PAWVTQF 117
L D ++ +EE L G+ E + + E AA R E A ++++
Sbjct: 1375 LHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEW 1434
Query: 118 VQKKEERDLVDRLKAEQARRKQRE-----ERLQQLQHRV-QLKYAAKRLRQEEEERENLL 171
+++EE E RR RE +RL + V +L+ +RL+QE ++ L
Sbjct: 1435 RRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL 1494
Query: 172 RLSREMLETGPEAER-LEQLESGEEELVL--------AEYESDEEKKVA---SRVDEDED 219
R+++ T + +R +QL + E+ VL AE E E + A +R E+E
Sbjct: 1495 EQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQ 1554
Query: 220 DLEEE-------HITKIYYCSRTHSQLAQFVHEVKKS-----PFGKDVRLVSLGSRQNLC 267
+ EE ++ + + + VHE++++ D+R L
Sbjct: 1555 EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELT 1614
Query: 268 VNEDVKSLGSVQLINDRCVDMQRSRHEKK-KGAEEEKPKRRRQ-EKQAACPFYNHEQMGL 325
ED K L + V +++HE+ +G +E +RRRQ KQ ++
Sbjct: 1615 AAEDAK------LRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERK 1668
Query: 326 LRDEALAEVKDMEQLLALGKEARACPYYGSRLAI 359
R A+A K +E L K A G A+
Sbjct: 1669 QRTLAVAARKKLEGELEELKAQMASAGQGKEEAV 1702
>gi|119120918 coiled-coil domain containing 64 [Homo sapiens]
Length = 573
Score = 50.8 bits (120), Expect = 5e-06
Identities = 56/246 (22%), Positives = 101/246 (41%), Gaps = 23/246 (9%)
Query: 71 EEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVDRL 130
EEE LL G P + S EGA P P+ +P ++ QK+++ L RL
Sbjct: 57 EEELALLAAGERPSDPGEHPQAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDLVLAARL 116
Query: 131 KAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERLEQL 190
R Q R + H+ +L + L QE+ E +RE G +E +
Sbjct: 117 GKALLERNQDMSRQYEQMHK-ELTDKLEHLEQEKHELRRRFE-NREGEWEGRVSELESDV 174
Query: 191 ESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSP 250
+ ++EL + E + SR ++ + + + ++ S QL+ VH +++
Sbjct: 175 KQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDF 234
Query: 251 FGKD-------VRLVSLGS--------------RQNLCVNEDVKSLGSVQLINDRCVDMQ 289
K+ +RL SL + R + + E+ G+V+ + DR + ++
Sbjct: 235 REKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILE 294
Query: 290 RSRHEK 295
R H+K
Sbjct: 295 RQGHDK 300
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 50.4 bits (119), Expect = 7e-06
Identities = 50/199 (25%), Positives = 90/199 (45%), Gaps = 26/199 (13%)
Query: 116 QFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSR 175
Q +++++E L RLK E+ R ++EER +Q KR EEE R+ LL+ S
Sbjct: 588 QRLKREQEERLEQRLKREEVERLEQEERREQ---------RLKREEPEEERRQQLLK-SE 637
Query: 176 EMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDED--EDDLEEEHITKIYYCS 233
E E + R EQ E E+ L E E E+++ +E+ E +L EE +
Sbjct: 638 EQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR--E 695
Query: 234 RTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRH 293
R S++ ++ +++ + ++ S +Q Q + +R R
Sbjct: 696 RIKSRIPKWQWQLESEADARQSKVYSRPRKQ------------EGQRRRQEQEEKRRRRE 743
Query: 294 EKKKGAEEEKPKRRRQEKQ 312
+ + EEE+ R++QE++
Sbjct: 744 SELQWQEEERAHRQQQEEE 762
Score = 50.4 bits (119), Expect = 7e-06
Identities = 50/226 (22%), Positives = 101/226 (44%), Gaps = 12/226 (5%)
Query: 120 KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLE 179
+++ERD R + +Q RR++RE + Q + +++ + ++ R+EE+ R+ + E
Sbjct: 1685 RRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE 1744
Query: 180 TGPEAERLEQLESGEEELVLAEYESDEE--KKVASRVDEDEDDLEEEHITKIYYCSRTHS 237
+ EQL EE L E D + ++ R + +E L + + + R
Sbjct: 1745 RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKF---REEE 1801
Query: 238 QLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQ----LINDRCVDMQRSRH 293
QL Q E + P +D + + L + E + L + ++ ++SR
Sbjct: 1802 QLRQEREEQQLRPQQRDGKY--RWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859
Query: 294 EKKKGAEEEKPKRRRQ-EKQAACPFYNHEQMGLLRDEALAEVKDME 338
E+++ +EE+ KRR++ E++ +Q R + E+K E
Sbjct: 1860 EEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQE 1905
Score = 49.3 bits (116), Expect = 2e-05
Identities = 53/197 (26%), Positives = 90/197 (45%), Gaps = 21/197 (10%)
Query: 120 KKEERDLVDRL-KAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
K+E+ + D+L K E+ RR+QR +R Q+ + +LK ++EE RE RL RE
Sbjct: 568 KREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQ--RLKRE-- 623
Query: 179 ETGPEAERLEQLESGEEELVLAEYE---SDEEKKVASRVDEDEDDLEEEHITKIYYCSRT 235
PE ER +QL EE+ + + +E++ E+E++ E+ + + + R
Sbjct: 624 --EPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERR 681
Query: 236 HSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEK 295
+LA+ E + R+ S + + + + S R + QR R E
Sbjct: 682 EQELAEEEQEQARE------RIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE- 734
Query: 296 KKGAEEEKPKRRRQEKQ 312
+EEK +RR E Q
Sbjct: 735 ----QEEKRRRRESELQ 747
Score = 48.1 bits (113), Expect = 3e-05
Identities = 47/198 (23%), Positives = 92/198 (46%), Gaps = 7/198 (3%)
Query: 116 QFVQKKEERDLVDR-LKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLS 174
Q +++ +E + +R LK E+ R++++ER +Q R Q + +RL+++EEE RL
Sbjct: 474 QQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR 533
Query: 175 REMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR 234
E + ER EQL EEE L E E E++ + + + L+ E + R
Sbjct: 534 SEQQLRREQEERREQLLKREEEKRL-EQERREQRLKREQEERRDQLLKREEERRQQRLKR 592
Query: 235 THSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHE 294
Q + +K+ + RL R+ E+ + QL+ + +R +
Sbjct: 593 --EQEERLEQRLKRE---EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQL 647
Query: 295 KKKGAEEEKPKRRRQEKQ 312
+++ E + + +R+E++
Sbjct: 648 RREQQERREQRLKREEEE 665
Score = 47.8 bits (112), Expect = 4e-05
Identities = 45/208 (21%), Positives = 90/208 (43%), Gaps = 19/208 (9%)
Query: 118 VQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREM 177
V +KEE L + Q ++ EE+L++L+ + +R RQEEE+++ LR +
Sbjct: 252 VLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ-----ELRRERQEEEQQQQRLR-REQQ 305
Query: 178 LETGPEAERLEQLESGEEELVLAEYESD----------EEKKVASRVDEDEDDLEEEHIT 227
L E ER EQ E E+ E + + EE++ E E++ E+ +
Sbjct: 306 LRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLR 365
Query: 228 KIYYCSRTHSQLAQFVHEVKKSPFGKDVRL---VSLGSRQNLCVNEDVKSLGSVQLINDR 284
+ R QL + ++ ++ +L L Q L + ++ ++
Sbjct: 366 REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 425
Query: 285 CVDMQRSRHEKKKGAEEEKPKRRRQEKQ 312
+ + RHE+K E + + +R++++
Sbjct: 426 RREQEEERHEQKHEQERREQRLKREQEE 453
Score = 47.8 bits (112), Expect = 4e-05
Identities = 67/237 (28%), Positives = 103/237 (43%), Gaps = 32/237 (13%)
Query: 115 TQFVQKKEERDLVDRLKAEQAR-RKQREERLQQLQ---------HRVQLKYAAKRLRQEE 164
+Q ++ ++DL L +Q R R+Q R QQ R + K A +R R+ +
Sbjct: 1256 SQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQ 1315
Query: 165 EERENLLRLSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEE 224
EE++ LLR RE E +R + EEE +L E E++ R + D EEE
Sbjct: 1316 EEKQ-LLREEREEKRRRQETDR----KFREEEQLLQE----REEQPLRRQERDRKFREEE 1366
Query: 225 HITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDR 284
R Q +F+ E ++ + R L Q L E + L + R
Sbjct: 1367 --------LRHQEQGRKFLEEEQRLRRQERERKF-LKEEQQLRCQEREQQLRQDRDRKFR 1417
Query: 285 CVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLL 341
+ Q SR E+ + EE+ + RRQE++ F EQ LR E + ++ EQLL
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQERER--KFLEEEQQ--LRQERHRKFREEEQLL 1470
Score = 47.0 bits (110), Expect = 8e-05
Identities = 70/308 (22%), Positives = 123/308 (39%), Gaps = 61/308 (19%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
++ KREEE LE H+E+ L+ + A + P W Q + + R
Sbjct: 657 QRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQ 716
Query: 126 LV----DRLKAEQARRKQREERLQQLQHRVQL--KYAAKRLRQEEEERENL--------- 170
R + Q RR+++EE+ ++ + +Q + A R +QEEE+R +
Sbjct: 717 SKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEK 776
Query: 171 -------------LRLSREMLETGPEAERLEQLESGEEE----------------LVLAE 201
LR RE E ++ EQ EEE L E
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE 836
Query: 202 YESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLG 261
E + ++ A ++ E+ED L+E+ + R + + E +K R +L
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR------RRHTLY 890
Query: 262 SRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHE 321
++ L E ++ QL+ + ++QR EK++ E+E+ R ++ Q E
Sbjct: 891 AKPAL--QEQLRK--EQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQ-------QE 939
Query: 322 QMGLLRDE 329
+ LLR+E
Sbjct: 940 EEQLLREE 947
Score = 46.6 bits (109), Expect = 1e-04
Identities = 59/238 (24%), Positives = 100/238 (42%), Gaps = 16/238 (6%)
Query: 119 QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
Q++E R+ + + +Q RR+Q+EER +Q R Q + ++LR+E+EE +L RE
Sbjct: 310 QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ- 368
Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
E ER EQ E++L + E++ + E L E + R Q
Sbjct: 369 ----EEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 424
Query: 239 L----AQFVHEVKKSPFGKDVRL--VSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSR 292
L + HE K ++ RL R L E+ + + D + R
Sbjct: 425 LRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER 484
Query: 293 HEK--KKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEAR 348
E+ K EE + ++ R+E+Q + L R E E + ++Q L ++ R
Sbjct: 485 RERWLKLEEEERREQQERREQQLRREQEERREQRLKRQE---EEERLQQRLRSEQQLR 539
Score = 46.6 bits (109), Expect = 1e-04
Identities = 58/229 (25%), Positives = 108/229 (47%), Gaps = 37/229 (16%)
Query: 120 KKEERDLVDRLKAEQARRKQ---REERL--QQLQHRVQ--LKYAAKRLRQEEEERENLLR 172
++EER + +Q RR+Q RE+RL Q+ + R+Q L+ + R++EE RE LL+
Sbjct: 492 EEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK 551
Query: 173 LSRE-MLETGPEAERLE-QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIY 230
E LE +RL+ + E ++L+ E E +++ + + E L+ E + ++
Sbjct: 552 REEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLE 611
Query: 231 YCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQR 290
R +L + E ++ RQ L +E+ + QL ++ Q
Sbjct: 612 QEERREQRLKREEPEEER--------------RQQLLKSEEQEERRQQQLRREQ----QE 653
Query: 291 SRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQ 339
R ++ K EEE+ +R +++ HE+ R++ LAE ++ EQ
Sbjct: 654 RREQRLKREEEEERLEQRLKRE-------HEEE--RREQELAE-EEQEQ 692
Score = 46.6 bits (109), Expect = 1e-04
Identities = 65/290 (22%), Positives = 121/290 (41%), Gaps = 21/290 (7%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
++ KRE+E RL + L E+ E L E P E +++EER
Sbjct: 588 QRLKREQEERLEQR----LKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER- 642
Query: 126 LVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAE 185
+ +Q RR+Q+E R Q+L+ + + +RL++E EE L+ E E E
Sbjct: 643 -----RQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERI 697
Query: 186 RLE------QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQL 239
+ QLES E + ++ S K+ R +++++ +++ + +
Sbjct: 698 KSRIPKWQWQLES-EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHR 756
Query: 240 AQFVHEVKKS-PFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
Q E ++ + S RQ L ++ QL + QR + +
Sbjct: 757 QQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE--RQQREQRFLPEE 814
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEAR 348
E+E+ +R+R+E++ F E+ L R E ++++ E L +E R
Sbjct: 815 EEKEQRRRQRREREKELQFLEEEEQ-LQRRERAQQLQEEEDGLQEDQERR 863
Score = 46.2 bits (108), Expect = 1e-04
Identities = 52/238 (21%), Positives = 98/238 (41%), Gaps = 46/238 (19%)
Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEE----ERENLLR---- 172
++ERD RL+ ++ RR+++E + + + +++ + ++LRQE + E E LL+
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE 1633
Query: 173 -------LSREMLETGPEAERLEQLES---------GEEELVLAEYESD----------- 205
R+ LE P+ R E+ + EEE +L E E
Sbjct: 1634 QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKF 1693
Query: 206 -EEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQ 264
EE++ R + + L+EE + R + Q E ++ + R + +
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEE 1753
Query: 265 NLCVNEDVKSL----------GSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQ 312
L + + L QL +R RS+ +K EEE+ ++ R+E+Q
Sbjct: 1754 QLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811
Score = 44.7 bits (104), Expect = 4e-04
Identities = 67/273 (24%), Positives = 107/273 (39%), Gaps = 63/273 (23%)
Query: 121 KEERDLVDRLKAEQARRKQREERL----QQLQHRVQLKYAAKRLRQEEEERENLLRLSRE 176
++ERD R + +Q RR++RE + QQL+ K+ + +E E + L R R+
Sbjct: 1425 RQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERD 1484
Query: 177 --MLETGPEAERLE--------QLESGEEELVLAEYESD-------------------EE 207
LE + R E +L S E E E E +E
Sbjct: 1485 RKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQE 1544
Query: 208 KKVASRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVK-------------KSPFGKD 254
+ R D D EEE + + R QL++ + K + F +D
Sbjct: 1545 RGQQRRQDRDRKFREEEQLRQ----EREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600
Query: 255 -VRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQA 313
+L +Q L D K QL+ +R + Q R E+ + EE+P+ RRQE++
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQER-EEQQLHRQERDRKFLEEEPQLRRQEREQ 1659
Query: 314 ACPFYNHEQMGLLRDEALAEVKDMEQLLALGKE 346
LR + + ++ EQLL G+E
Sbjct: 1660 Q-----------LRHDRDRKFREEEQLLQEGEE 1681
Score = 44.7 bits (104), Expect = 4e-04
Identities = 57/218 (26%), Positives = 89/218 (40%), Gaps = 33/218 (15%)
Query: 63 RDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKE 122
++ E+K REEE ET L ++ L RP E + +++
Sbjct: 1719 QELERKFREEEQLRQETEQEQLRRQERYRKILEEE------QLRPEREEQQL-----RRQ 1767
Query: 123 ERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-------RENLLRLSR 175
ERD + + E+ R++REE+ + Q + ++LRQE EE R+ R
Sbjct: 1768 ERDR--KFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEE 1825
Query: 176 EMLETGPEAERLEQLES----GEEELVLAEYESDEEKKV-----ASRVDEDEDDLEEEHI 226
E L+ + +RL Q EE+ E EE+++ R E E L EEHI
Sbjct: 1826 EQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHI 1885
Query: 227 TKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQ 264
+ + H Q V E+K RL+ G+ Q
Sbjct: 1886 RRQQKEEQRHRQ----VGEIKSQEGKGHGRLLEPGTHQ 1919
Score = 44.3 bits (103), Expect = 5e-04
Identities = 51/231 (22%), Positives = 103/231 (44%), Gaps = 24/231 (10%)
Query: 116 QFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSR 175
Q +Q++EE L+ E+ +++R+E+ +Q + QL+ ++L +EE E+ R
Sbjct: 904 QLLQEEEEE-----LQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERER 958
Query: 176 EMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDL--EEEHITKIYYCS 233
+ + ++ EQL GEE E +++ + + ++E+ L EE +
Sbjct: 959 QYRKDKKLQQKEEQL-LGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE 1017
Query: 234 RTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIND-----RCVDM 288
R + + + E ++ ++ L R+ E+ QL+ + R ++
Sbjct: 1018 RQYRKKDELQQE-EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 289 QRS-------RHEKKKGAEEEKPKRRRQEKQAAC---PFYNHEQMGLLRDE 329
+R + E+++ EE KRRRQE++ C E+ LLR+E
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREE 1127
Score = 43.5 bits (101), Expect = 8e-04
Identities = 46/204 (22%), Positives = 94/204 (46%), Gaps = 11/204 (5%)
Query: 113 WVTQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLR 172
W Q+ +K E + + EQ R++RE+R +LQ R + + L+QEEE+ R
Sbjct: 1016 WERQYRKKDELQQ-----EEEQLLREEREKR--RLQERERQYREEEELQQEEEQLLGEER 1068
Query: 173 LSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDED-DLEEEHITKIYY 231
+R E + + E+L+ EE+L+ E E ++ + E+E+ EEE + +
Sbjct: 1069 ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128
Query: 232 CSRTHSQL-AQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCV--DM 288
R +L Q+ E + + + R+ + + +Q ++ + +
Sbjct: 1129 EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQ 1188
Query: 289 QRSRHEKKKGAEEEKPKRRRQEKQ 312
++ R E+++ EE+ +R++ KQ
Sbjct: 1189 EKRRQERERQYREEEELQRQKRKQ 1212
Score = 43.5 bits (101), Expect = 8e-04
Identities = 54/221 (24%), Positives = 97/221 (43%), Gaps = 26/221 (11%)
Query: 116 QFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSR 175
Q +Q++EE+ L + ++ RK REE L+ + + +RLR++E ER+ L +
Sbjct: 1343 QLLQEREEQPL----RRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398
Query: 176 EMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRT 235
+ ER +QL + + EE++ SR + D EEE + R
Sbjct: 1399 LRCQ-----EREQQLRQDRDR------KFREEEQQLSRQERDRKFREEEQQVRRQERERK 1447
Query: 236 HSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNE-DVKSLGSVQLINDRCVDMQ----- 289
+ Q + + + F ++ +L+ Q L E D K L Q + + D +
Sbjct: 1448 FLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQE 1507
Query: 290 -RSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDE 329
RS+ ++K EEE+ R+Q ++ + E+ L R E
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRK----FLQEEQQLRRQE 1544
Score = 43.1 bits (100), Expect = 0.001
Identities = 39/197 (19%), Positives = 89/197 (45%), Gaps = 6/197 (3%)
Query: 116 QFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSR 175
Q ++++++ +L+ EQ R+++EE + +H + + +RL++E+EER + L+
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR--EQRLKREQEERRDWLKREE 462
Query: 176 EMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRT 235
E E + R +QL+ +EE + EE++ + + E L E + +
Sbjct: 463 E-TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKR 521
Query: 236 HSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEK 295
+ + ++ + +R R+ L E+ K L + + + R +
Sbjct: 522 QEEEERLQQRLRSE---QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL 578
Query: 296 KKGAEEEKPKRRRQEKQ 312
K EE + +R ++E++
Sbjct: 579 LKREEERRQQRLKREQE 595
Score = 42.0 bits (97), Expect = 0.002
Identities = 49/194 (25%), Positives = 81/194 (41%), Gaps = 35/194 (18%)
Query: 119 QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
Q++ R+ R K E+ RR+Q+EER +Q + R Q+EE RE LR RE
Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERR----------EQQEERREQQLR--REQE 344
Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
E + R EQ E E+ + E E + ++ R E L E + R Q
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRR----EQQLRREQQLRREQQLRREQQ 400
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
L R L Q L + ++ QL ++ + +HE+++
Sbjct: 401 LR---------------REQQLRREQQLRREQQLRR--EQQLRREQEEERHEQKHEQER- 442
Query: 299 AEEEKPKRRRQEKQ 312
E++ KR ++E++
Sbjct: 443 -REQRLKREQEERR 455
Score = 42.0 bits (97), Expect = 0.002
Identities = 45/214 (21%), Positives = 97/214 (45%), Gaps = 28/214 (13%)
Query: 116 QFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSR 175
Q+ +++E + ++L E+ +++R+E +Q + +L+ ++L +EE+E+ R +
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQ 1198
Query: 176 EMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRT 235
E + ++ +Q E++ +++ + EK+ A R + K+Y R
Sbjct: 1199 YREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDN------------KVYCKGRE 1246
Query: 236 HSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEK 295
+ Q Q +D +L S+Q D++ L Q DR + +R +
Sbjct: 1247 NEQFRQL----------EDSQLRDRQSQQ------DLQHLLGEQQERDREQERRRWQQRD 1290
Query: 296 KKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDE 329
+ EEE+ +R Q++ + E+ LLR+E
Sbjct: 1291 RHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE 1324
Score = 41.6 bits (96), Expect = 0.003
Identities = 58/265 (21%), Positives = 109/265 (41%), Gaps = 47/265 (17%)
Query: 63 RDFEQKKREEEARLLETGTGPLHDEKDESLC----LSSSCEGAAGT-PRPAGEPAWVTQF 117
R+ EQ ++EEE L E E++ L E G P ++
Sbjct: 931 REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990
Query: 118 VQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREM 177
+++E + ++L E+ +++R+E +Q + + +L+ ++L +EE E+ L R+
Sbjct: 991 REEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY 1050
Query: 178 LETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHS 237
E E L+Q EEE +L E ++ R E++L++E
Sbjct: 1051 ----REEEELQQ----EEEQLLGEERETRRRQELERQYRKEEELQQE-----------EE 1091
Query: 238 QLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIND-----RCVDMQRSR 292
QL + E ++ R+ C E+ QL+ + R +++R
Sbjct: 1092 QLLREEPEKRRRQ-----------ERERQCREEEELQQEEEQLLREEREKRRRQELERQY 1140
Query: 293 HEKKKGAEEEK-------PKRRRQE 310
E+++ +EE+ KRRRQE
Sbjct: 1141 REEEEVQQEEEQLLREEPEKRRRQE 1165
Score = 41.2 bits (95), Expect = 0.004
Identities = 52/227 (22%), Positives = 102/227 (44%), Gaps = 17/227 (7%)
Query: 131 KAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERLEQL 190
+ +Q RR+Q+ R QQL+ QL+ ++LR+E+EE + + +E E + E+ E+
Sbjct: 397 REQQLRREQQLRREQQLRREQQLR-REQQLRREQEEERHEQKHEQERREQRLKREQEERR 455
Query: 191 ESGEEELVLAEYESDEEKKVASRVDEDED-----DLEEEHITKIYYCSRTHSQLAQFVHE 245
+ + E +E + K+ R E+E LEEE + R QL + E
Sbjct: 456 DWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEE--RREQQERREQQLRREQEE 513
Query: 246 VKKSPFGK---DVRLVS-LGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEE 301
++ + + RL L S Q L ++ + ++ ++ ++ +R K+ EE
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE 573
Query: 302 EKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEAR 348
+ + ++E++ EQ +E L + E++ L +E R
Sbjct: 574 RRDQLLKREEERRQQRLKREQ-----EERLEQRLKREEVERLEQEER 615
Score = 38.9 bits (89), Expect = 0.021
Identities = 64/322 (19%), Positives = 137/322 (42%), Gaps = 29/322 (9%)
Query: 25 DFMAELYRVLEAGKIGIFESPTGTGKSLSLIC-GALSWLRDFEQKKREEEARLLETGTGP 83
+F+ +++V +A + ++ TG + C G S L+D +++EE+ R E
Sbjct: 73 EFLLFIFKVAQACYYALGQA-TGLDEEKRARCDGKESLLQD---RRQEEDQRRFEPRDRQ 128
Query: 84 LHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVDRLKAEQARRKQREER 143
L +E + + R E ++ ++ E+RD R + +R++ +ER
Sbjct: 129 LEEEPGQR-----RRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQER 183
Query: 144 LQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEA-ERLEQLESGEEELVLAEY 202
++ QL+ +E + E L R RE+LE + E +Q ++ V E
Sbjct: 184 EERRAEEEQLQSCKGHETEEFPDEEQLRR--RELLELRRKGREEKQQQRRERQDRVFQEE 241
Query: 203 ESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLAQFV-HEVKKSPFGKDVRLVSLG 261
E E +K + + ++E+ L+EE + QL + E+++ ++ + L
Sbjct: 242 EEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLR 301
Query: 262 SRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKR----RRQEKQAACPF 317
Q L ++ + + Q R E+++ E+++ +R RR++++
Sbjct: 302 REQQLRRKQE-----------EERREQQEERREQQERREQQEERREQQLRREQEERREQQ 350
Query: 318 YNHEQMGLLRDEALAEVKDMEQ 339
EQ R++ L ++ E+
Sbjct: 351 LRREQEEERREQQLRREQEEER 372
Score = 38.5 bits (88), Expect = 0.027
Identities = 29/107 (27%), Positives = 53/107 (49%), Gaps = 2/107 (1%)
Query: 120 KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLE 179
+++ RD R + E+ R+++R + + QL+ + L++EEEE + R R E
Sbjct: 866 QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQE 925
Query: 180 TGPEAERLEQLESGEEELVLAEYES--DEEKKVASRVDEDEDDLEEE 224
+ EQL+ EE+L+ E E +E++ R D+ EE+
Sbjct: 926 QERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQ 972
Score = 38.1 bits (87), Expect = 0.035
Identities = 54/232 (23%), Positives = 103/232 (44%), Gaps = 34/232 (14%)
Query: 119 QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLR-QEEEER--ENLLRLSR 175
Q++++RD R + EQ R+++ E++L + + + + +++R QE+E + E+ +L R
Sbjct: 1548 QRRQDRDRKFR-EEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRR 1606
Query: 176 EMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRT 235
+ + ER + E+ L + E++ R + D LEEE R
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLL------QEREEQQLHRQERDRKFLEEEPQL------RR 1654
Query: 236 HSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEK 295
+ Q H+ + F ++ +L+ G Q L E + R + Q R E+
Sbjct: 1655 QEREQQLRHD-RDRKFREEEQLLQEGEEQQLRRQERDRKF--------REEEQQLRRQER 1705
Query: 296 KKGAEEEKPKRRRQEKQAACPFYNHEQM-------GLLRDEALAEVKDMEQL 340
++ +E+ + RRQE + F EQ+ L R E ++ + EQL
Sbjct: 1706 ERKFLQEEQQLRRQELER--KFREEEQLRQETEQEQLRRQERYRKILEEEQL 1755
>gi|22758136 MAP7 domain containing 2 [Homo sapiens]
Length = 732
Score = 50.1 bits (118), Expect = 9e-06
Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 41/187 (21%)
Query: 66 EQKKREEEARLLETGTGPL------------HDEKDESLCLSSSCEGAAGTPRP------ 107
E+ +E E L + GP H + + E +A +P
Sbjct: 337 EKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTD 396
Query: 108 AGEPAWVT------------QFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKY 155
AGE A + Q Q++ E++ DRL+ E+ +RK EERL+ L+ + K
Sbjct: 397 AGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLR-LEEEAR-KQ 454
Query: 156 AAKRLRQEEEERENLLRLSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVD 215
+R RQEEE+++ + E + G EA+R EEEL+L E + ++EK+ + ++
Sbjct: 455 EEERKRQEEEKKK---QEGEEKRKAGEEAKR-----KAEEELLLKE-KQEQEKQEKAMIE 505
Query: 216 EDEDDLE 222
+ ++ E
Sbjct: 506 KQKEAAE 512
Score = 33.5 bits (75), Expect = 0.86
Identities = 23/83 (27%), Positives = 39/83 (46%), Gaps = 6/83 (7%)
Query: 119 QKKEERDLVDRLKAEQARRKQREERL------QQLQHRVQLKYAAKRLRQEEEERENLLR 172
+KK++ R E+A+RK EE L Q+ Q + ++ + + E +R
Sbjct: 464 EKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMR 523
Query: 173 LSREMLETGPEAERLEQLESGEE 195
L RE + E ERLE+ + +E
Sbjct: 524 LEREQIMLQIEQERLERKKRIDE 546
Score = 33.1 bits (74), Expect = 1.1
Identities = 30/124 (24%), Positives = 53/124 (42%), Gaps = 11/124 (8%)
Query: 79 TGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVDRLKAEQARRK 138
TG+ P + SL + GA T +P P + F++ E + L + RR+
Sbjct: 10 TGSRPEGTARGTSLPGKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLA------KERRE 63
Query: 139 QREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLS-----REMLETGPEAERLEQLESG 193
+RE+ L + ++ K RL+ E++ E +L + E +R ++L
Sbjct: 64 EREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREE 123
Query: 194 EEEL 197
EE L
Sbjct: 124 EERL 127
Score = 31.6 bits (70), Expect = 3.3
Identities = 29/103 (28%), Positives = 52/103 (50%), Gaps = 13/103 (12%)
Query: 119 QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEEREN----LLRLS 174
+K+EE +R + E+ ++KQ E ++ + K + L +E++E+E ++
Sbjct: 452 RKQEE----ERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQ 507
Query: 175 REMLETGPEAERLEQLESGEEELVL-AEYESDEEKKVASRVDE 216
+E ET E EQ+ E+++L E E E KK R+DE
Sbjct: 508 KEAAET-KAREVAEQMRLEREQIMLQIEQERLERKK---RIDE 546
Score = 31.2 bits (69), Expect = 4.3
Identities = 24/77 (31%), Positives = 40/77 (51%), Gaps = 10/77 (12%)
Query: 116 QFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEER-ENLLRLS 174
Q ++K++ L + E+ RK E+R ++ Q R ++ K+ +EEEER E ++R S
Sbjct: 75 QILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRS 134
Query: 175 REMLETGPEAERLEQLE 191
ER +QLE
Sbjct: 135 ---------LERTQQLE 142
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 48.9 bits (115), Expect = 2e-05
Identities = 43/146 (29%), Positives = 73/146 (50%), Gaps = 9/146 (6%)
Query: 67 QKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDL 126
++K+EEEAR L + + + L E + A Q Q++ E++
Sbjct: 638 RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 697
Query: 127 VDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEE--ERENLLRLSREMLETGPE 183
++ + EQ RR+Q R E+ +QL + + + +RL+ E E ERE LRL +E L+
Sbjct: 698 REQERREQERREQERREQERQLAEQ-ERRREQERLQAERELQEREKALRLQKEQLQ---- 752
Query: 184 AERLEQLESGEEELVLAEYESDEEKK 209
LE+ + EE+ LAE + EE++
Sbjct: 753 -RELEEKKKKEEQQRLAERQLQEEQE 777
Score = 47.8 bits (112), Expect = 4e-05
Identities = 52/199 (26%), Positives = 90/199 (45%), Gaps = 32/199 (16%)
Query: 118 VQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLR---QEEEERENLLRLS 174
+ +K E+ +RL E+A++K +++++++ R + + A+RLR QEEEER +
Sbjct: 606 IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH----- 660
Query: 175 REMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR 234
+E+L+ E E+ E+L E LAE E ++ R E + E +
Sbjct: 661 QELLQKKKEEEQ-ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERR-----E 714
Query: 235 THSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHE 294
QLA+ ++ L + + L E L QL QR E
Sbjct: 715 QERQLAEQERRREQE---------RLQAERELQEREKALRLQKEQL--------QRELEE 757
Query: 295 KKKGAEEEK-PKRRRQEKQ 312
KKK E+++ +R+ QE+Q
Sbjct: 758 KKKKEEQQRLAERQLQEEQ 776
Score = 46.6 bits (109), Expect = 1e-04
Identities = 56/236 (23%), Positives = 107/236 (45%), Gaps = 38/236 (16%)
Query: 118 VQKKEERDLVDRLKAEQARRKQREE-RLQQLQHRVQLKYAAKRLRQEEEERENLLRLSRE 176
+++KEE + + R K E+ +R++ EE +L++ + ++ A +R+ Q +EE++ +
Sbjct: 545 LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFA 604
Query: 177 MLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDE-DDLEEEHITKIYYC--- 232
++ E+ E +EE LAE E ++K A +++E E +EE ++ +
Sbjct: 605 QID--------EKTEKAKEER-LAE-EKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 654
Query: 233 --SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQR 290
R H +L Q E ++ K L ++ E Q
Sbjct: 655 EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE------------------QE 696
Query: 291 SRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKE 346
R ++++ E + +RR QE+Q A EQ L +A E+++ E+ L L KE
Sbjct: 697 RREQERREQERREQERREQERQLAEQERRREQERL---QAERELQEREKALRLQKE 749
Score = 40.4 bits (93), Expect = 0.007
Identities = 40/165 (24%), Positives = 75/165 (45%), Gaps = 6/165 (3%)
Query: 63 RDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKE 122
+ EQK + + + + L +EK + + E + E + Q++E
Sbjct: 597 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 656
Query: 123 ERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLS--REMLET 180
ER + L Q ++++ +ERL++ +L ++ R+E+E RE R RE
Sbjct: 657 ERRHQELL---QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERR 713
Query: 181 GPEAERLEQLESGEEELVLAEYESDE-EKKVASRVDEDEDDLEEE 224
E + EQ E+E + AE E E EK + + ++ + +LEE+
Sbjct: 714 EQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK 758
Score = 40.4 bits (93), Expect = 0.007
Identities = 31/121 (25%), Positives = 60/121 (49%), Gaps = 9/121 (7%)
Query: 116 QFVQKKEERDLVDRLK--------AEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEER 167
+ +QKK+E + +RL+ AEQ +++RE+ ++ + R Q + +R QE +
Sbjct: 662 ELLQKKKEEEQ-ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 720
Query: 168 ENLLRLSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
E R +E L+ E + E+ ++E + E E ++K+ R+ E + E+E
Sbjct: 721 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 780
Query: 228 K 228
K
Sbjct: 781 K 781
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 48.9 bits (115), Expect = 2e-05
Identities = 43/146 (29%), Positives = 73/146 (50%), Gaps = 9/146 (6%)
Query: 67 QKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDL 126
++K+EEEAR L + + + L E + A Q Q++ E++
Sbjct: 634 RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 693
Query: 127 VDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEE--ERENLLRLSREMLETGPE 183
++ + EQ RR+Q R E+ +QL + + + +RL+ E E ERE LRL +E L+
Sbjct: 694 REQERREQERREQERREQERQLAEQ-ERRREQERLQAERELQEREKALRLQKEQLQ---- 748
Query: 184 AERLEQLESGEEELVLAEYESDEEKK 209
LE+ + EE+ LAE + EE++
Sbjct: 749 -RELEEKKKKEEQQRLAERQLQEEQE 773
Score = 47.8 bits (112), Expect = 4e-05
Identities = 52/199 (26%), Positives = 90/199 (45%), Gaps = 32/199 (16%)
Query: 118 VQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLR---QEEEERENLLRLS 174
+ +K E+ +RL E+A++K +++++++ R + + A+RLR QEEEER +
Sbjct: 602 IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH----- 656
Query: 175 REMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR 234
+E+L+ E E+ E+L E LAE E ++ R E + E +
Sbjct: 657 QELLQKKKEEEQ-ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERR-----E 710
Query: 235 THSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHE 294
QLA+ ++ L + + L E L QL QR E
Sbjct: 711 QERQLAEQERRREQE---------RLQAERELQEREKALRLQKEQL--------QRELEE 753
Query: 295 KKKGAEEEK-PKRRRQEKQ 312
KKK E+++ +R+ QE+Q
Sbjct: 754 KKKKEEQQRLAERQLQEEQ 772
Score = 46.6 bits (109), Expect = 1e-04
Identities = 62/239 (25%), Positives = 109/239 (45%), Gaps = 36/239 (15%)
Query: 120 KKEERDLVDRLK----AEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSR 175
K++ER ++ L+ AEQ RR++ EE ++ V+LK +RLR+ + RE + ++
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLK-REERLRKVLQARERVEQMKE 589
Query: 176 EMLETGPE--AERLEQLESGEEELVLAEYESDEEKKVASRVDEDE-DDLEEEHITKIYYC 232
E + + A+ E+ E +EE LAE E ++K A +++E E +EE ++ +
Sbjct: 590 EKKKQIEQKFAQIDEKTEKAKEER-LAE-EKAKKKAAAKKMEEVEARRKQEEEARRLRWL 647
Query: 233 -----SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVD 287
R H +L Q E ++ K L ++ E
Sbjct: 648 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE----------------- 690
Query: 288 MQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKE 346
Q R ++++ E + +RR QE+Q A EQ L +A E+++ E+ L L KE
Sbjct: 691 -QERREQERREQERREQERREQERQLAEQERRREQERL---QAERELQEREKALRLQKE 745
Score = 40.4 bits (93), Expect = 0.007
Identities = 40/165 (24%), Positives = 75/165 (45%), Gaps = 6/165 (3%)
Query: 63 RDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKE 122
+ EQK + + + + L +EK + + E + E + Q++E
Sbjct: 593 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 652
Query: 123 ERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLS--REMLET 180
ER + L Q ++++ +ERL++ +L ++ R+E+E RE R RE
Sbjct: 653 ERRHQELL---QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERR 709
Query: 181 GPEAERLEQLESGEEELVLAEYESDE-EKKVASRVDEDEDDLEEE 224
E + EQ E+E + AE E E EK + + ++ + +LEE+
Sbjct: 710 EQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK 754
Score = 40.4 bits (93), Expect = 0.007
Identities = 31/121 (25%), Positives = 60/121 (49%), Gaps = 9/121 (7%)
Query: 116 QFVQKKEERDLVDRLK--------AEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEER 167
+ +QKK+E + +RL+ AEQ +++RE+ ++ + R Q + +R QE +
Sbjct: 658 ELLQKKKEEEQ-ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 716
Query: 168 ENLLRLSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
E R +E L+ E + E+ ++E + E E ++K+ R+ E + E+E
Sbjct: 717 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 776
Query: 228 K 228
K
Sbjct: 777 K 777
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 48.5 bits (114), Expect = 3e-05
Identities = 72/284 (25%), Positives = 120/284 (42%), Gaps = 35/284 (12%)
Query: 71 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510
Query: 125 -----DLVDRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
+L R+KAE ++++ LQ L+ R+Q + A +RLRQ E ER ++++ E
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570
Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
+ EAE L+S + A + + E L+EEH+ + +
Sbjct: 1571 QRSAEAE----LQS-------------KRASFAEKTAQLERSLQEEHVA-VAQLREEAER 1612
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
AQ E +++ + L R L NE ++ + + + Q ++K+
Sbjct: 1613 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
AE E +R + E+QA EQ L + LAE ++L A
Sbjct: 1669 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1711
Score = 45.1 bits (105), Expect = 3e-04
Identities = 80/376 (21%), Positives = 154/376 (40%), Gaps = 40/376 (10%)
Query: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316
Query: 128 DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
++ E R K E LQQ + Q + A+RL++++E+ L + + EAER
Sbjct: 2317 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 188 EQLESGEE---------ELVLAEYESDEE----KKVASRVDEDEDDLEEEHITKIYYCSR 234
QLE E E+ A+ ++E+ +K A + E E K+
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 235 THSQLAQFVH------------EVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIN 282
Q Q H E +K ++ +L+ L S + V ++ + L Q +
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQ 2492
Query: 283 DRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDMEQL 340
+ + S ++++ E+EK K + Q++ A EQ R + E ++ ++L
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQRL 2548
Query: 341 LALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLI 399
+A +EAR + + +L L Q RL++Q+ +++E H
Sbjct: 2549 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR-- 2606
Query: 400 DTITGMHSVEVSGSQL 415
HS EV+ SQ+
Sbjct: 2607 --AALAHSEEVTASQV 2620
Score = 42.4 bits (98), Expect = 0.002
Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 32/278 (11%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1352 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1400
Query: 126 LVDRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
+V R +A Q +++ +E LQQL+ + + AK RLR EEE R L+
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 173 LSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYC 232
L + G L+ L + EE + ++ EE + R +DE + + ++
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--AEVELA 1518
Query: 233 SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSR 292
SR ++ + + +++RL + + + L +V+ VQ+ + +
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAE 1577
Query: 293 HEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEA 330
+ K+ + EK + + Q H + LR+EA
Sbjct: 1578 LQSKRASFAEKTAQLERSLQE-----EHVAVAQLREEA 1610
Score = 42.0 bits (97), Expect = 0.002
Identities = 89/382 (23%), Positives = 152/382 (39%), Gaps = 64/382 (16%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
E ++ E++ +LLE L E + E R E ++ ++E R
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 126 LVD----RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLSRE 176
+ RL+AE R ++ E +L+ L AKR RQ EE R R+ E
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837
Query: 177 MLETGPEAERLE--------QLESGEEELV-LAEYESDEEKKVASRVDEDEDDLEEEHIT 227
L EA RL+ + E+ E L LAE E+ + +++ + + + D+EE
Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE---- 1893
Query: 228 KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSL---------GSV 278
+LAQ + + S + LV RQ V E++ +L G
Sbjct: 1894 ----------RLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 279 QL------INDRCVDMQRSRHE-------KKKGAEEEKPKRRRQEKQAACPFYNHEQMGL 325
+L I D RS+ + +++ A EE+ +RR E++ E+
Sbjct: 1943 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2002
Query: 326 LRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATR-QAAGIR 384
R AL EV E+L A +EAR + + QL Q L A + A ++
Sbjct: 2003 QRKAALEEV---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059
Query: 385 LQDQVV--IIDEAHNLIDTITG 404
++Q + + + +++D + G
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRG 2081
Score = 40.4 bits (93), Expect = 0.007
Identities = 46/211 (21%), Positives = 85/211 (40%), Gaps = 19/211 (9%)
Query: 120 KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE--------RENLL 171
K EE+ + R AEQ KQR+ Q R+ + RLR E E+ E L
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737
Query: 172 RLSREMLETGPEAERLE----QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
RL RE + + LE ++ + E L+ ++ ++EE + S + + E
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797
Query: 228 KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC-- 285
++ + ++L E K+ + + + E + ++G +
Sbjct: 1798 EL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1854
Query: 286 --VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
+ + ++ AE+E +RRR E+QAA
Sbjct: 1855 ALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1885
Score = 37.4 bits (85), Expect = 0.060
Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 25/194 (12%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2517
Query: 123 ERDLVDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
+ + KA+Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2571
Query: 182 PEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR-THSQLA 240
E ++LEQ +EEL+ E + R+ E LEE+H + + T SQ+A
Sbjct: 2572 -ELQQLEQQRRQQEELLAEENQ---------RLREQLQLLEEQHRAALAHSEEVTASQVA 2621
Query: 241 QFVHEVKKSPFGKD 254
K P G+D
Sbjct: 2622 ----ATKTLPNGRD 2631
Score = 33.9 bits (76), Expect = 0.66
Identities = 62/292 (21%), Positives = 108/292 (36%), Gaps = 39/292 (13%)
Query: 62 LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSS------SCEGAAGTPRPAG-EPAWV 114
++D Q+KR+ E L +++ L + E A R A E A
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562
Query: 115 TQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKY-AAKRLRQEEEER-ENLLR 172
Q + +R L Q++R E+ QL+ +Q ++ A +LR+E E R +
Sbjct: 1563 VQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE 1619
Query: 173 LSREMLETGPEAERLE-----------QLESGEEELVLAEYESDEEKKVASRVDEDEDDL 221
R E E ER + Q E ++ LA+ E++++K+ A R
Sbjct: 1620 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679
Query: 222 EEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
EE+ + + + + Q + + L+ L + E + QL+
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-------ETEQGEQQRQLL 1732
Query: 282 NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAE 333
+ +QR E ++RQE +A E LL +A AE
Sbjct: 1733 EEELARLQR---------EAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775
Score = 33.9 bits (76), Expect = 0.66
Identities = 75/391 (19%), Positives = 141/391 (36%), Gaps = 48/391 (12%)
Query: 59 LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
L+ LR + E + L+E ++E L L +S E AA AG+
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1942
Query: 119 QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
L+ E R + E + + + +L+ A +R EEER R
Sbjct: 1943 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1992
Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
E E Q ++ EE+ + + +E +++ R +++ S Q
Sbjct: 1993 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE---------------SARQLQ 2037
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNL--CVNEDVKSLGSVQLINDRCVDMQRSRHEKK 296
LAQ + + K Q L + ++ L ++ + E +
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097
Query: 297 KGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSR 356
AE E + RRQ ++A + E+ R +A A + + + RA +
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 357 LAIPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTITGMHSVEVS 411
AA + ++ RQ A + L+ Q+ D NL+D + ++
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAE 2215
Query: 412 GSQLCQAHSQLLQYVERYGKRLKAKNLMYLK 442
++ + SQ+ + E + R++ + L LK
Sbjct: 2216 ATEAARQRSQVEE--ELFSVRVQMEELSKLK 2244
Score = 32.3 bits (72), Expect = 1.9
Identities = 24/97 (24%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
+EE L ++ +AE+ R E + Q ++ +A + + E E +E R+ E++
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 181 GPEA-ERLEQLESGEEELVLAEYESDEEKKVASRVDE 216
A + +Q S +EEL S+ E + +R E
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1441
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 48.5 bits (114), Expect = 3e-05
Identities = 72/284 (25%), Positives = 120/284 (42%), Gaps = 35/284 (12%)
Query: 71 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1455 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1514
Query: 125 -----DLVDRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
+L R+KAE ++++ LQ L+ R+Q + A +RLRQ E ER ++++ E
Sbjct: 1515 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1574
Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
+ EAE L+S + A + + E L+EEH+ + +
Sbjct: 1575 QRSAEAE----LQS-------------KRASFAEKTAQLERSLQEEHVA-VAQLREEAER 1616
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
AQ E +++ + L R L NE ++ + + + Q ++K+
Sbjct: 1617 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1672
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
AE E +R + E+QA EQ L + LAE ++L A
Sbjct: 1673 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1715
Score = 45.1 bits (105), Expect = 3e-04
Identities = 80/376 (21%), Positives = 154/376 (40%), Gaps = 40/376 (10%)
Query: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2261 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2320
Query: 128 DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
++ E R K E LQQ + Q + A+RL++++E+ L + + EAER
Sbjct: 2321 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377
Query: 188 EQLESGEE---------ELVLAEYESDEE----KKVASRVDEDEDDLEEEHITKIYYCSR 234
QLE E E+ A+ ++E+ +K A + E E K+
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2437
Query: 235 THSQLAQFVH------------EVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIN 282
Q Q H E +K ++ +L+ L S + V ++ + L Q +
Sbjct: 2438 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQ 2496
Query: 283 DRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDMEQL 340
+ + S ++++ E+EK K + Q++ A EQ R + E ++ ++L
Sbjct: 2497 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQRL 2552
Query: 341 LALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLI 399
+A +EAR + + +L L Q RL++Q+ +++E H
Sbjct: 2553 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR-- 2610
Query: 400 DTITGMHSVEVSGSQL 415
HS EV+ SQ+
Sbjct: 2611 --AALAHSEEVTASQV 2624
Score = 42.4 bits (98), Expect = 0.002
Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 32/278 (11%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1356 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1404
Query: 126 LVDRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
+V R +A Q +++ +E LQQL+ + + AK RLR EEE R L+
Sbjct: 1405 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1464
Query: 173 LSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYC 232
L + G L+ L + EE + ++ EE + R +DE + + ++
Sbjct: 1465 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--AEVELA 1522
Query: 233 SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSR 292
SR ++ + + +++RL + + + L +V+ VQ+ + +
Sbjct: 1523 SRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAE 1581
Query: 293 HEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEA 330
+ K+ + EK + + Q H + LR+EA
Sbjct: 1582 LQSKRASFAEKTAQLERSLQE-----EHVAVAQLREEA 1614
Score = 42.0 bits (97), Expect = 0.002
Identities = 89/382 (23%), Positives = 152/382 (39%), Gaps = 64/382 (16%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
E ++ E++ +LLE L E + E R E ++ ++E R
Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1784
Query: 126 LVD----RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLSRE 176
+ RL+AE R ++ E +L+ L AKR RQ EE R R+ E
Sbjct: 1785 TSEKSKQRLEAEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAE 1841
Query: 177 MLETGPEAERLE--------QLESGEEELV-LAEYESDEEKKVASRVDEDEDDLEEEHIT 227
L EA RL+ + E+ E L LAE E+ + +++ + + + D+EE
Sbjct: 1842 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE---- 1897
Query: 228 KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSL---------GSV 278
+LAQ + + S + LV RQ V E++ +L G
Sbjct: 1898 ----------RLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1946
Query: 279 QL------INDRCVDMQRSRHE-------KKKGAEEEKPKRRRQEKQAACPFYNHEQMGL 325
+L I D RS+ + +++ A EE+ +RR E++ E+
Sbjct: 1947 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2006
Query: 326 LRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATR-QAAGIR 384
R AL EV E+L A +EAR + + QL Q L A + A ++
Sbjct: 2007 QRKAALEEV---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2063
Query: 385 LQDQVV--IIDEAHNLIDTITG 404
++Q + + + +++D + G
Sbjct: 2064 QKEQELQQTLQQEQSVLDQLRG 2085
Score = 40.4 bits (93), Expect = 0.007
Identities = 46/211 (21%), Positives = 85/211 (40%), Gaps = 19/211 (9%)
Query: 120 KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE--------RENLL 171
K EE+ + R AEQ KQR+ Q R+ + RLR E E+ E L
Sbjct: 1682 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1741
Query: 172 RLSREMLETGPEAERLE----QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
RL RE + + LE ++ + E L+ ++ ++EE + S + + E
Sbjct: 1742 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1801
Query: 228 KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC-- 285
++ + ++L E K+ + + + E + ++G +
Sbjct: 1802 EL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1858
Query: 286 --VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
+ + ++ AE+E +RRR E+QAA
Sbjct: 1859 ALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1889
Score = 37.4 bits (85), Expect = 0.060
Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 25/194 (12%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2462 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2521
Query: 123 ERDLVDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
+ + KA+Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2522 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2575
Query: 182 PEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR-THSQLA 240
E ++LEQ +EEL+ E + R+ E LEE+H + + T SQ+A
Sbjct: 2576 -ELQQLEQQRRQQEELLAEENQ---------RLREQLQLLEEQHRAALAHSEEVTASQVA 2625
Query: 241 QFVHEVKKSPFGKD 254
K P G+D
Sbjct: 2626 ----ATKTLPNGRD 2635
Score = 33.9 bits (76), Expect = 0.66
Identities = 62/292 (21%), Positives = 108/292 (36%), Gaps = 39/292 (13%)
Query: 62 LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSS------SCEGAAGTPRPAG-EPAWV 114
++D Q+KR+ E L +++ L + E A R A E A
Sbjct: 1507 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1566
Query: 115 TQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKY-AAKRLRQEEEER-ENLLR 172
Q + +R L Q++R E+ QL+ +Q ++ A +LR+E E R +
Sbjct: 1567 VQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE 1623
Query: 173 LSREMLETGPEAERLE-----------QLESGEEELVLAEYESDEEKKVASRVDEDEDDL 221
R E E ER + Q E ++ LA+ E++++K+ A R
Sbjct: 1624 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1683
Query: 222 EEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
EE+ + + + + Q + + L+ L + E + QL+
Sbjct: 1684 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-------ETEQGEQQRQLL 1736
Query: 282 NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAE 333
+ +QR E ++RQE +A E LL +A AE
Sbjct: 1737 EEELARLQR---------EAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1779
Score = 33.9 bits (76), Expect = 0.66
Identities = 75/391 (19%), Positives = 141/391 (36%), Gaps = 48/391 (12%)
Query: 59 LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
L+ LR + E + L+E ++E L L +S E AA AG+
Sbjct: 1899 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1946
Query: 119 QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
L+ E R + E + + + +L+ A +R EEER R
Sbjct: 1947 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1996
Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
E E Q ++ EE+ + + +E +++ R +++ S Q
Sbjct: 1997 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE---------------SARQLQ 2041
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNL--CVNEDVKSLGSVQLINDRCVDMQRSRHEKK 296
LAQ + + K Q L + ++ L ++ + E +
Sbjct: 2042 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2101
Query: 297 KGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSR 356
AE E + RRQ ++A + E+ R +A A + + + RA +
Sbjct: 2102 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2161
Query: 357 LAIPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTITGMHSVEVS 411
AA + ++ RQ A + L+ Q+ D NL+D + ++
Sbjct: 2162 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAE 2219
Query: 412 GSQLCQAHSQLLQYVERYGKRLKAKNLMYLK 442
++ + SQ+ + E + R++ + L LK
Sbjct: 2220 ATEAARQRSQVEE--ELFSVRVQMEELSKLK 2248
Score = 32.3 bits (72), Expect = 1.9
Identities = 24/97 (24%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
+EE L ++ +AE+ R E + Q ++ +A + + E E +E R+ E++
Sbjct: 1349 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1408
Query: 181 GPEA-ERLEQLESGEEELVLAEYESDEEKKVASRVDE 216
A + +Q S +EEL S+ E + +R E
Sbjct: 1409 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1445
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 48.5 bits (114), Expect = 3e-05
Identities = 72/284 (25%), Positives = 120/284 (42%), Gaps = 35/284 (12%)
Query: 71 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510
Query: 125 -----DLVDRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
+L R+KAE ++++ LQ L+ R+Q + A +RLRQ E ER ++++ E
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570
Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
+ EAE L+S + A + + E L+EEH+ + +
Sbjct: 1571 QRSAEAE----LQS-------------KRASFAEKTAQLERSLQEEHVA-VAQLREEAER 1612
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
AQ E +++ + L R L NE ++ + + + Q ++K+
Sbjct: 1613 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
AE E +R + E+QA EQ L + LAE ++L A
Sbjct: 1669 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1711
Score = 45.1 bits (105), Expect = 3e-04
Identities = 80/376 (21%), Positives = 154/376 (40%), Gaps = 40/376 (10%)
Query: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316
Query: 128 DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
++ E R K E LQQ + Q + A+RL++++E+ L + + EAER
Sbjct: 2317 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 188 EQLESGEE---------ELVLAEYESDEE----KKVASRVDEDEDDLEEEHITKIYYCSR 234
QLE E E+ A+ ++E+ +K A + E E K+
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 235 THSQLAQFVH------------EVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIN 282
Q Q H E +K ++ +L+ L S + V ++ + L Q +
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQ 2492
Query: 283 DRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDMEQL 340
+ + S ++++ E+EK K + Q++ A EQ R + E ++ ++L
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQRL 2548
Query: 341 LALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLI 399
+A +EAR + + +L L Q RL++Q+ +++E H
Sbjct: 2549 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR-- 2606
Query: 400 DTITGMHSVEVSGSQL 415
HS EV+ SQ+
Sbjct: 2607 --AALAHSEEVTASQV 2620
Score = 42.4 bits (98), Expect = 0.002
Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 32/278 (11%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1352 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1400
Query: 126 LVDRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
+V R +A Q +++ +E LQQL+ + + AK RLR EEE R L+
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 173 LSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYC 232
L + G L+ L + EE + ++ EE + R +DE + + ++
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--AEVELA 1518
Query: 233 SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSR 292
SR ++ + + +++RL + + + L +V+ VQ+ + +
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAE 1577
Query: 293 HEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEA 330
+ K+ + EK + + Q H + LR+EA
Sbjct: 1578 LQSKRASFAEKTAQLERSLQE-----EHVAVAQLREEA 1610
Score = 42.0 bits (97), Expect = 0.002
Identities = 89/382 (23%), Positives = 152/382 (39%), Gaps = 64/382 (16%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
E ++ E++ +LLE L E + E R E ++ ++E R
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 126 LVD----RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLSRE 176
+ RL+AE R ++ E +L+ L AKR RQ EE R R+ E
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837
Query: 177 MLETGPEAERLE--------QLESGEEELV-LAEYESDEEKKVASRVDEDEDDLEEEHIT 227
L EA RL+ + E+ E L LAE E+ + +++ + + + D+EE
Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE---- 1893
Query: 228 KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSL---------GSV 278
+LAQ + + S + LV RQ V E++ +L G
Sbjct: 1894 ----------RLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 279 QL------INDRCVDMQRSRHE-------KKKGAEEEKPKRRRQEKQAACPFYNHEQMGL 325
+L I D RS+ + +++ A EE+ +RR E++ E+
Sbjct: 1943 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2002
Query: 326 LRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATR-QAAGIR 384
R AL EV E+L A +EAR + + QL Q L A + A ++
Sbjct: 2003 QRKAALEEV---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059
Query: 385 LQDQVV--IIDEAHNLIDTITG 404
++Q + + + +++D + G
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRG 2081
Score = 40.4 bits (93), Expect = 0.007
Identities = 46/211 (21%), Positives = 85/211 (40%), Gaps = 19/211 (9%)
Query: 120 KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE--------RENLL 171
K EE+ + R AEQ KQR+ Q R+ + RLR E E+ E L
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737
Query: 172 RLSREMLETGPEAERLE----QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
RL RE + + LE ++ + E L+ ++ ++EE + S + + E
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797
Query: 228 KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC-- 285
++ + ++L E K+ + + + E + ++G +
Sbjct: 1798 EL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1854
Query: 286 --VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
+ + ++ AE+E +RRR E+QAA
Sbjct: 1855 ALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1885
Score = 37.4 bits (85), Expect = 0.060
Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 25/194 (12%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2517
Query: 123 ERDLVDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
+ + KA+Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2571
Query: 182 PEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR-THSQLA 240
E ++LEQ +EEL+ E + R+ E LEE+H + + T SQ+A
Sbjct: 2572 -ELQQLEQQRRQQEELLAEENQ---------RLREQLQLLEEQHRAALAHSEEVTASQVA 2621
Query: 241 QFVHEVKKSPFGKD 254
K P G+D
Sbjct: 2622 ----ATKTLPNGRD 2631
Score = 33.9 bits (76), Expect = 0.66
Identities = 62/292 (21%), Positives = 108/292 (36%), Gaps = 39/292 (13%)
Query: 62 LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSS------SCEGAAGTPRPAG-EPAWV 114
++D Q+KR+ E L +++ L + E A R A E A
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562
Query: 115 TQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKY-AAKRLRQEEEER-ENLLR 172
Q + +R L Q++R E+ QL+ +Q ++ A +LR+E E R +
Sbjct: 1563 VQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE 1619
Query: 173 LSREMLETGPEAERLE-----------QLESGEEELVLAEYESDEEKKVASRVDEDEDDL 221
R E E ER + Q E ++ LA+ E++++K+ A R
Sbjct: 1620 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679
Query: 222 EEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
EE+ + + + + Q + + L+ L + E + QL+
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-------ETEQGEQQRQLL 1732
Query: 282 NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAE 333
+ +QR E ++RQE +A E LL +A AE
Sbjct: 1733 EEELARLQR---------EAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775
Score = 33.9 bits (76), Expect = 0.66
Identities = 75/391 (19%), Positives = 141/391 (36%), Gaps = 48/391 (12%)
Query: 59 LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
L+ LR + E + L+E ++E L L +S E AA AG+
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1942
Query: 119 QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
L+ E R + E + + + +L+ A +R EEER R
Sbjct: 1943 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1992
Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
E E Q ++ EE+ + + +E +++ R +++ S Q
Sbjct: 1993 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE---------------SARQLQ 2037
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNL--CVNEDVKSLGSVQLINDRCVDMQRSRHEKK 296
LAQ + + K Q L + ++ L ++ + E +
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097
Query: 297 KGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSR 356
AE E + RRQ ++A + E+ R +A A + + + RA +
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 357 LAIPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTITGMHSVEVS 411
AA + ++ RQ A + L+ Q+ D NL+D + ++
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAE 2215
Query: 412 GSQLCQAHSQLLQYVERYGKRLKAKNLMYLK 442
++ + SQ+ + E + R++ + L LK
Sbjct: 2216 ATEAARQRSQVEE--ELFSVRVQMEELSKLK 2244
Score = 32.3 bits (72), Expect = 1.9
Identities = 24/97 (24%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
+EE L ++ +AE+ R E + Q ++ +A + + E E +E R+ E++
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 181 GPEA-ERLEQLESGEEELVLAEYESDEEKKVASRVDE 216
A + +Q S +EEL S+ E + +R E
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1441
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 48.5 bits (114), Expect = 3e-05
Identities = 72/284 (25%), Positives = 120/284 (42%), Gaps = 35/284 (12%)
Query: 71 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1419 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1478
Query: 125 -----DLVDRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
+L R+KAE ++++ LQ L+ R+Q + A +RLRQ E ER ++++ E
Sbjct: 1479 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1538
Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
+ EAE L+S + A + + E L+EEH+ + +
Sbjct: 1539 QRSAEAE----LQS-------------KRASFAEKTAQLERSLQEEHVA-VAQLREEAER 1580
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
AQ E +++ + L R L NE ++ + + + Q ++K+
Sbjct: 1581 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1636
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
AE E +R + E+QA EQ L + LAE ++L A
Sbjct: 1637 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1679
Score = 45.1 bits (105), Expect = 3e-04
Identities = 80/376 (21%), Positives = 154/376 (40%), Gaps = 40/376 (10%)
Query: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2225 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2284
Query: 128 DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
++ E R K E LQQ + Q + A+RL++++E+ L + + EAER
Sbjct: 2285 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341
Query: 188 EQLESGEE---------ELVLAEYESDEE----KKVASRVDEDEDDLEEEHITKIYYCSR 234
QLE E E+ A+ ++E+ +K A + E E K+
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2401
Query: 235 THSQLAQFVH------------EVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIN 282
Q Q H E +K ++ +L+ L S + V ++ + L Q +
Sbjct: 2402 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQ 2460
Query: 283 DRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDMEQL 340
+ + S ++++ E+EK K + Q++ A EQ R + E ++ ++L
Sbjct: 2461 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQRL 2516
Query: 341 LALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLI 399
+A +EAR + + +L L Q RL++Q+ +++E H
Sbjct: 2517 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR-- 2574
Query: 400 DTITGMHSVEVSGSQL 415
HS EV+ SQ+
Sbjct: 2575 --AALAHSEEVTASQV 2588
Score = 42.4 bits (98), Expect = 0.002
Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 32/278 (11%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1320 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1368
Query: 126 LVDRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
+V R +A Q +++ +E LQQL+ + + AK RLR EEE R L+
Sbjct: 1369 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1428
Query: 173 LSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYC 232
L + G L+ L + EE + ++ EE + R +DE + + ++
Sbjct: 1429 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--AEVELA 1486
Query: 233 SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSR 292
SR ++ + + +++RL + + + L +V+ VQ+ + +
Sbjct: 1487 SRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAE 1545
Query: 293 HEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEA 330
+ K+ + EK + + Q H + LR+EA
Sbjct: 1546 LQSKRASFAEKTAQLERSLQE-----EHVAVAQLREEA 1578
Score = 42.0 bits (97), Expect = 0.002
Identities = 89/382 (23%), Positives = 152/382 (39%), Gaps = 64/382 (16%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
E ++ E++ +LLE L E + E R E ++ ++E R
Sbjct: 1689 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1748
Query: 126 LVD----RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLSRE 176
+ RL+AE R ++ E +L+ L AKR RQ EE R R+ E
Sbjct: 1749 TSEKSKQRLEAEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAE 1805
Query: 177 MLETGPEAERLE--------QLESGEEELV-LAEYESDEEKKVASRVDEDEDDLEEEHIT 227
L EA RL+ + E+ E L LAE E+ + +++ + + + D+EE
Sbjct: 1806 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE---- 1861
Query: 228 KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSL---------GSV 278
+LAQ + + S + LV RQ V E++ +L G
Sbjct: 1862 ----------RLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1910
Query: 279 QL------INDRCVDMQRSRHE-------KKKGAEEEKPKRRRQEKQAACPFYNHEQMGL 325
+L I D RS+ + +++ A EE+ +RR E++ E+
Sbjct: 1911 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1970
Query: 326 LRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATR-QAAGIR 384
R AL EV E+L A +EAR + + QL Q L A + A ++
Sbjct: 1971 QRKAALEEV---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2027
Query: 385 LQDQVV--IIDEAHNLIDTITG 404
++Q + + + +++D + G
Sbjct: 2028 QKEQELQQTLQQEQSVLDQLRG 2049
Score = 40.4 bits (93), Expect = 0.007
Identities = 46/211 (21%), Positives = 85/211 (40%), Gaps = 19/211 (9%)
Query: 120 KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE--------RENLL 171
K EE+ + R AEQ KQR+ Q R+ + RLR E E+ E L
Sbjct: 1646 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1705
Query: 172 RLSREMLETGPEAERLE----QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
RL RE + + LE ++ + E L+ ++ ++EE + S + + E
Sbjct: 1706 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1765
Query: 228 KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC-- 285
++ + ++L E K+ + + + E + ++G +
Sbjct: 1766 EL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1822
Query: 286 --VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
+ + ++ AE+E +RRR E+QAA
Sbjct: 1823 ALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1853
Score = 37.4 bits (85), Expect = 0.060
Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 25/194 (12%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2426 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2485
Query: 123 ERDLVDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
+ + KA+Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2486 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2539
Query: 182 PEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR-THSQLA 240
E ++LEQ +EEL+ E + R+ E LEE+H + + T SQ+A
Sbjct: 2540 -ELQQLEQQRRQQEELLAEENQ---------RLREQLQLLEEQHRAALAHSEEVTASQVA 2589
Query: 241 QFVHEVKKSPFGKD 254
K P G+D
Sbjct: 2590 ----ATKTLPNGRD 2599
Score = 33.9 bits (76), Expect = 0.66
Identities = 62/292 (21%), Positives = 108/292 (36%), Gaps = 39/292 (13%)
Query: 62 LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSS------SCEGAAGTPRPAG-EPAWV 114
++D Q+KR+ E L +++ L + E A R A E A
Sbjct: 1471 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1530
Query: 115 TQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKY-AAKRLRQEEEER-ENLLR 172
Q + +R L Q++R E+ QL+ +Q ++ A +LR+E E R +
Sbjct: 1531 VQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE 1587
Query: 173 LSREMLETGPEAERLE-----------QLESGEEELVLAEYESDEEKKVASRVDEDEDDL 221
R E E ER + Q E ++ LA+ E++++K+ A R
Sbjct: 1588 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1647
Query: 222 EEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
EE+ + + + + Q + + L+ L + E + QL+
Sbjct: 1648 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-------ETEQGEQQRQLL 1700
Query: 282 NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAE 333
+ +QR E ++RQE +A E LL +A AE
Sbjct: 1701 EEELARLQR---------EAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1743
Score = 33.9 bits (76), Expect = 0.66
Identities = 75/391 (19%), Positives = 141/391 (36%), Gaps = 48/391 (12%)
Query: 59 LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
L+ LR + E + L+E ++E L L +S E AA AG+
Sbjct: 1863 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1910
Query: 119 QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
L+ E R + E + + + +L+ A +R EEER R
Sbjct: 1911 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1960
Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
E E Q ++ EE+ + + +E +++ R +++ S Q
Sbjct: 1961 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE---------------SARQLQ 2005
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNL--CVNEDVKSLGSVQLINDRCVDMQRSRHEKK 296
LAQ + + K Q L + ++ L ++ + E +
Sbjct: 2006 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2065
Query: 297 KGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSR 356
AE E + RRQ ++A + E+ R +A A + + + RA +
Sbjct: 2066 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2125
Query: 357 LAIPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTITGMHSVEVS 411
AA + ++ RQ A + L+ Q+ D NL+D + ++
Sbjct: 2126 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAE 2183
Query: 412 GSQLCQAHSQLLQYVERYGKRLKAKNLMYLK 442
++ + SQ+ + E + R++ + L LK
Sbjct: 2184 ATEAARQRSQVEE--ELFSVRVQMEELSKLK 2212
Score = 32.3 bits (72), Expect = 1.9
Identities = 24/97 (24%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
+EE L ++ +AE+ R E + Q ++ +A + + E E +E R+ E++
Sbjct: 1313 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1372
Query: 181 GPEA-ERLEQLESGEEELVLAEYESDEEKKVASRVDE 216
A + +Q S +EEL S+ E + +R E
Sbjct: 1373 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1409
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 48.5 bits (114), Expect = 3e-05
Identities = 72/284 (25%), Positives = 120/284 (42%), Gaps = 35/284 (12%)
Query: 71 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1588 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1647
Query: 125 -----DLVDRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
+L R+KAE ++++ LQ L+ R+Q + A +RLRQ E ER ++++ E
Sbjct: 1648 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1707
Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
+ EAE L+S + A + + E L+EEH+ + +
Sbjct: 1708 QRSAEAE----LQS-------------KRASFAEKTAQLERSLQEEHVA-VAQLREEAER 1749
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
AQ E +++ + L R L NE ++ + + + Q ++K+
Sbjct: 1750 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1805
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
AE E +R + E+QA EQ L + LAE ++L A
Sbjct: 1806 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1848
Score = 45.1 bits (105), Expect = 3e-04
Identities = 80/376 (21%), Positives = 154/376 (40%), Gaps = 40/376 (10%)
Query: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2394 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2453
Query: 128 DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
++ E R K E LQQ + Q + A+RL++++E+ L + + EAER
Sbjct: 2454 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510
Query: 188 EQLESGEE---------ELVLAEYESDEE----KKVASRVDEDEDDLEEEHITKIYYCSR 234
QLE E E+ A+ ++E+ +K A + E E K+
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2570
Query: 235 THSQLAQFVH------------EVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIN 282
Q Q H E +K ++ +L+ L S + V ++ + L Q +
Sbjct: 2571 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQ 2629
Query: 283 DRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDMEQL 340
+ + S ++++ E+EK K + Q++ A EQ R + E ++ ++L
Sbjct: 2630 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQRL 2685
Query: 341 LALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLI 399
+A +EAR + + +L L Q RL++Q+ +++E H
Sbjct: 2686 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR-- 2743
Query: 400 DTITGMHSVEVSGSQL 415
HS EV+ SQ+
Sbjct: 2744 --AALAHSEEVTASQV 2757
Score = 42.4 bits (98), Expect = 0.002
Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 32/278 (11%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1489 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1537
Query: 126 LVDRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
+V R +A Q +++ +E LQQL+ + + AK RLR EEE R L+
Sbjct: 1538 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1597
Query: 173 LSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYC 232
L + G L+ L + EE + ++ EE + R +DE + + ++
Sbjct: 1598 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--AEVELA 1655
Query: 233 SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSR 292
SR ++ + + +++RL + + + L +V+ VQ+ + +
Sbjct: 1656 SRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAE 1714
Query: 293 HEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEA 330
+ K+ + EK + + Q H + LR+EA
Sbjct: 1715 LQSKRASFAEKTAQLERSLQE-----EHVAVAQLREEA 1747
Score = 42.0 bits (97), Expect = 0.002
Identities = 89/382 (23%), Positives = 152/382 (39%), Gaps = 64/382 (16%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
E ++ E++ +LLE L E + E R E ++ ++E R
Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1917
Query: 126 LVD----RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLSRE 176
+ RL+AE R ++ E +L+ L AKR RQ EE R R+ E
Sbjct: 1918 TSEKSKQRLEAEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAE 1974
Query: 177 MLETGPEAERLE--------QLESGEEELV-LAEYESDEEKKVASRVDEDEDDLEEEHIT 227
L EA RL+ + E+ E L LAE E+ + +++ + + + D+EE
Sbjct: 1975 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE---- 2030
Query: 228 KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSL---------GSV 278
+LAQ + + S + LV RQ V E++ +L G
Sbjct: 2031 ----------RLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 2079
Query: 279 QL------INDRCVDMQRSRHE-------KKKGAEEEKPKRRRQEKQAACPFYNHEQMGL 325
+L I D RS+ + +++ A EE+ +RR E++ E+
Sbjct: 2080 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2139
Query: 326 LRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATR-QAAGIR 384
R AL EV E+L A +EAR + + QL Q L A + A ++
Sbjct: 2140 QRKAALEEV---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2196
Query: 385 LQDQVV--IIDEAHNLIDTITG 404
++Q + + + +++D + G
Sbjct: 2197 QKEQELQQTLQQEQSVLDQLRG 2218
Score = 40.4 bits (93), Expect = 0.007
Identities = 46/211 (21%), Positives = 85/211 (40%), Gaps = 19/211 (9%)
Query: 120 KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE--------RENLL 171
K EE+ + R AEQ KQR+ Q R+ + RLR E E+ E L
Sbjct: 1815 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1874
Query: 172 RLSREMLETGPEAERLE----QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
RL RE + + LE ++ + E L+ ++ ++EE + S + + E
Sbjct: 1875 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1934
Query: 228 KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC-- 285
++ + ++L E K+ + + + E + ++G +
Sbjct: 1935 EL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1991
Query: 286 --VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
+ + ++ AE+E +RRR E+QAA
Sbjct: 1992 ALKEKEAENERLRRLAEDEAFQRRRLEEQAA 2022
Score = 37.4 bits (85), Expect = 0.060
Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 25/194 (12%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2595 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2654
Query: 123 ERDLVDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
+ + KA+Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2655 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2708
Query: 182 PEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR-THSQLA 240
E ++LEQ +EEL+ E + R+ E LEE+H + + T SQ+A
Sbjct: 2709 -ELQQLEQQRRQQEELLAEENQ---------RLREQLQLLEEQHRAALAHSEEVTASQVA 2758
Query: 241 QFVHEVKKSPFGKD 254
K P G+D
Sbjct: 2759 ----ATKTLPNGRD 2768
Score = 33.9 bits (76), Expect = 0.66
Identities = 62/292 (21%), Positives = 108/292 (36%), Gaps = 39/292 (13%)
Query: 62 LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSS------SCEGAAGTPRPAG-EPAWV 114
++D Q+KR+ E L +++ L + E A R A E A
Sbjct: 1640 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1699
Query: 115 TQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKY-AAKRLRQEEEER-ENLLR 172
Q + +R L Q++R E+ QL+ +Q ++ A +LR+E E R +
Sbjct: 1700 VQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE 1756
Query: 173 LSREMLETGPEAERLE-----------QLESGEEELVLAEYESDEEKKVASRVDEDEDDL 221
R E E ER + Q E ++ LA+ E++++K+ A R
Sbjct: 1757 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1816
Query: 222 EEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
EE+ + + + + Q + + L+ L + E + QL+
Sbjct: 1817 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-------ETEQGEQQRQLL 1869
Query: 282 NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAE 333
+ +QR E ++RQE +A E LL +A AE
Sbjct: 1870 EEELARLQR---------EAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1912
Score = 33.9 bits (76), Expect = 0.66
Identities = 75/391 (19%), Positives = 141/391 (36%), Gaps = 48/391 (12%)
Query: 59 LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
L+ LR + E + L+E ++E L L +S E AA AG+
Sbjct: 2032 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 2079
Query: 119 QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
L+ E R + E + + + +L+ A +R EEER R
Sbjct: 2080 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 2129
Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
E E Q ++ EE+ + + +E +++ R +++ S Q
Sbjct: 2130 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE---------------SARQLQ 2174
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNL--CVNEDVKSLGSVQLINDRCVDMQRSRHEKK 296
LAQ + + K Q L + ++ L ++ + E +
Sbjct: 2175 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2234
Query: 297 KGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSR 356
AE E + RRQ ++A + E+ R +A A + + + RA +
Sbjct: 2235 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2294
Query: 357 LAIPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTITGMHSVEVS 411
AA + ++ RQ A + L+ Q+ D NL+D + ++
Sbjct: 2295 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAE 2352
Query: 412 GSQLCQAHSQLLQYVERYGKRLKAKNLMYLK 442
++ + SQ+ + E + R++ + L LK
Sbjct: 2353 ATEAARQRSQVEE--ELFSVRVQMEELSKLK 2381
Score = 32.3 bits (72), Expect = 1.9
Identities = 24/97 (24%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
+EE L ++ +AE+ R E + Q ++ +A + + E E +E R+ E++
Sbjct: 1482 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1541
Query: 181 GPEA-ERLEQLESGEEELVLAEYESDEEKKVASRVDE 216
A + +Q S +EEL S+ E + +R E
Sbjct: 1542 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1578
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 48.5 bits (114), Expect = 3e-05
Identities = 72/284 (25%), Positives = 120/284 (42%), Gaps = 35/284 (12%)
Query: 71 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1429 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1488
Query: 125 -----DLVDRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
+L R+KAE ++++ LQ L+ R+Q + A +RLRQ E ER ++++ E
Sbjct: 1489 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1548
Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
+ EAE L+S + A + + E L+EEH+ + +
Sbjct: 1549 QRSAEAE----LQS-------------KRASFAEKTAQLERSLQEEHVA-VAQLREEAER 1590
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
AQ E +++ + L R L NE ++ + + + Q ++K+
Sbjct: 1591 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1646
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
AE E +R + E+QA EQ L + LAE ++L A
Sbjct: 1647 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1689
Score = 45.1 bits (105), Expect = 3e-04
Identities = 80/376 (21%), Positives = 154/376 (40%), Gaps = 40/376 (10%)
Query: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2235 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2294
Query: 128 DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
++ E R K E LQQ + Q + A+RL++++E+ L + + EAER
Sbjct: 2295 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351
Query: 188 EQLESGEE---------ELVLAEYESDEE----KKVASRVDEDEDDLEEEHITKIYYCSR 234
QLE E E+ A+ ++E+ +K A + E E K+
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2411
Query: 235 THSQLAQFVH------------EVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIN 282
Q Q H E +K ++ +L+ L S + V ++ + L Q +
Sbjct: 2412 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQ 2470
Query: 283 DRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDMEQL 340
+ + S ++++ E+EK K + Q++ A EQ R + E ++ ++L
Sbjct: 2471 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQRL 2526
Query: 341 LALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLI 399
+A +EAR + + +L L Q RL++Q+ +++E H
Sbjct: 2527 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR-- 2584
Query: 400 DTITGMHSVEVSGSQL 415
HS EV+ SQ+
Sbjct: 2585 --AALAHSEEVTASQV 2598
Score = 42.4 bits (98), Expect = 0.002
Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 32/278 (11%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1330 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1378
Query: 126 LVDRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
+V R +A Q +++ +E LQQL+ + + AK RLR EEE R L+
Sbjct: 1379 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1438
Query: 173 LSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYC 232
L + G L+ L + EE + ++ EE + R +DE + + ++
Sbjct: 1439 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--AEVELA 1496
Query: 233 SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSR 292
SR ++ + + +++RL + + + L +V+ VQ+ + +
Sbjct: 1497 SRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAE 1555
Query: 293 HEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEA 330
+ K+ + EK + + Q H + LR+EA
Sbjct: 1556 LQSKRASFAEKTAQLERSLQE-----EHVAVAQLREEA 1588
Score = 42.0 bits (97), Expect = 0.002
Identities = 89/382 (23%), Positives = 152/382 (39%), Gaps = 64/382 (16%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
E ++ E++ +LLE L E + E R E ++ ++E R
Sbjct: 1699 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1758
Query: 126 LVD----RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLSRE 176
+ RL+AE R ++ E +L+ L AKR RQ EE R R+ E
Sbjct: 1759 TSEKSKQRLEAEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAE 1815
Query: 177 MLETGPEAERLE--------QLESGEEELV-LAEYESDEEKKVASRVDEDEDDLEEEHIT 227
L EA RL+ + E+ E L LAE E+ + +++ + + + D+EE
Sbjct: 1816 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE---- 1871
Query: 228 KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSL---------GSV 278
+LAQ + + S + LV RQ V E++ +L G
Sbjct: 1872 ----------RLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920
Query: 279 QL------INDRCVDMQRSRHE-------KKKGAEEEKPKRRRQEKQAACPFYNHEQMGL 325
+L I D RS+ + +++ A EE+ +RR E++ E+
Sbjct: 1921 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1980
Query: 326 LRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATR-QAAGIR 384
R AL EV E+L A +EAR + + QL Q L A + A ++
Sbjct: 1981 QRKAALEEV---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2037
Query: 385 LQDQVV--IIDEAHNLIDTITG 404
++Q + + + +++D + G
Sbjct: 2038 QKEQELQQTLQQEQSVLDQLRG 2059
Score = 40.4 bits (93), Expect = 0.007
Identities = 46/211 (21%), Positives = 85/211 (40%), Gaps = 19/211 (9%)
Query: 120 KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE--------RENLL 171
K EE+ + R AEQ KQR+ Q R+ + RLR E E+ E L
Sbjct: 1656 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1715
Query: 172 RLSREMLETGPEAERLE----QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
RL RE + + LE ++ + E L+ ++ ++EE + S + + E
Sbjct: 1716 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1775
Query: 228 KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC-- 285
++ + ++L E K+ + + + E + ++G +
Sbjct: 1776 EL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1832
Query: 286 --VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
+ + ++ AE+E +RRR E+QAA
Sbjct: 1833 ALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1863
Score = 37.4 bits (85), Expect = 0.060
Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 25/194 (12%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2436 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2495
Query: 123 ERDLVDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
+ + KA+Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2496 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2549
Query: 182 PEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR-THSQLA 240
E ++LEQ +EEL+ E + R+ E LEE+H + + T SQ+A
Sbjct: 2550 -ELQQLEQQRRQQEELLAEENQ---------RLREQLQLLEEQHRAALAHSEEVTASQVA 2599
Query: 241 QFVHEVKKSPFGKD 254
K P G+D
Sbjct: 2600 ----ATKTLPNGRD 2609
Score = 33.9 bits (76), Expect = 0.66
Identities = 62/292 (21%), Positives = 108/292 (36%), Gaps = 39/292 (13%)
Query: 62 LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSS------SCEGAAGTPRPAG-EPAWV 114
++D Q+KR+ E L +++ L + E A R A E A
Sbjct: 1481 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1540
Query: 115 TQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKY-AAKRLRQEEEER-ENLLR 172
Q + +R L Q++R E+ QL+ +Q ++ A +LR+E E R +
Sbjct: 1541 VQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE 1597
Query: 173 LSREMLETGPEAERLE-----------QLESGEEELVLAEYESDEEKKVASRVDEDEDDL 221
R E E ER + Q E ++ LA+ E++++K+ A R
Sbjct: 1598 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1657
Query: 222 EEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
EE+ + + + + Q + + L+ L + E + QL+
Sbjct: 1658 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-------ETEQGEQQRQLL 1710
Query: 282 NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAE 333
+ +QR E ++RQE +A E LL +A AE
Sbjct: 1711 EEELARLQR---------EAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1753
Score = 33.9 bits (76), Expect = 0.66
Identities = 75/391 (19%), Positives = 141/391 (36%), Gaps = 48/391 (12%)
Query: 59 LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
L+ LR + E + L+E ++E L L +S E AA AG+
Sbjct: 1873 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1920
Query: 119 QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
L+ E R + E + + + +L+ A +R EEER R
Sbjct: 1921 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1970
Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
E E Q ++ EE+ + + +E +++ R +++ S Q
Sbjct: 1971 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE---------------SARQLQ 2015
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNL--CVNEDVKSLGSVQLINDRCVDMQRSRHEKK 296
LAQ + + K Q L + ++ L ++ + E +
Sbjct: 2016 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2075
Query: 297 KGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSR 356
AE E + RRQ ++A + E+ R +A A + + + RA +
Sbjct: 2076 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2135
Query: 357 LAIPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTITGMHSVEVS 411
AA + ++ RQ A + L+ Q+ D NL+D + ++
Sbjct: 2136 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAE 2193
Query: 412 GSQLCQAHSQLLQYVERYGKRLKAKNLMYLK 442
++ + SQ+ + E + R++ + L LK
Sbjct: 2194 ATEAARQRSQVEE--ELFSVRVQMEELSKLK 2222
Score = 32.3 bits (72), Expect = 1.9
Identities = 24/97 (24%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
+EE L ++ +AE+ R E + Q ++ +A + + E E +E R+ E++
Sbjct: 1323 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1382
Query: 181 GPEA-ERLEQLESGEEELVLAEYESDEEKKVASRVDE 216
A + +Q S +EEL S+ E + +R E
Sbjct: 1383 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1419
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 48.5 bits (114), Expect = 3e-05
Identities = 72/284 (25%), Positives = 120/284 (42%), Gaps = 35/284 (12%)
Query: 71 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1437 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1496
Query: 125 -----DLVDRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
+L R+KAE ++++ LQ L+ R+Q + A +RLRQ E ER ++++ E
Sbjct: 1497 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1556
Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
+ EAE L+S + A + + E L+EEH+ + +
Sbjct: 1557 QRSAEAE----LQS-------------KRASFAEKTAQLERSLQEEHVA-VAQLREEAER 1598
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
AQ E +++ + L R L NE ++ + + + Q ++K+
Sbjct: 1599 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1654
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
AE E +R + E+QA EQ L + LAE ++L A
Sbjct: 1655 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1697
Score = 45.1 bits (105), Expect = 3e-04
Identities = 80/376 (21%), Positives = 154/376 (40%), Gaps = 40/376 (10%)
Query: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2243 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2302
Query: 128 DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
++ E R K E LQQ + Q + A+RL++++E+ L + + EAER
Sbjct: 2303 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2359
Query: 188 EQLESGEE---------ELVLAEYESDEE----KKVASRVDEDEDDLEEEHITKIYYCSR 234
QLE E E+ A+ ++E+ +K A + E E K+
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2419
Query: 235 THSQLAQFVH------------EVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIN 282
Q Q H E +K ++ +L+ L S + V ++ + L Q +
Sbjct: 2420 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQ 2478
Query: 283 DRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDMEQL 340
+ + S ++++ E+EK K + Q++ A EQ R + E ++ ++L
Sbjct: 2479 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQRL 2534
Query: 341 LALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLI 399
+A +EAR + + +L L Q RL++Q+ +++E H
Sbjct: 2535 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR-- 2592
Query: 400 DTITGMHSVEVSGSQL 415
HS EV+ SQ+
Sbjct: 2593 --AALAHSEEVTASQV 2606
Score = 42.4 bits (98), Expect = 0.002
Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 32/278 (11%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1338 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1386
Query: 126 LVDRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
+V R +A Q +++ +E LQQL+ + + AK RLR EEE R L+
Sbjct: 1387 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1446
Query: 173 LSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYC 232
L + G L+ L + EE + ++ EE + R +DE + + ++
Sbjct: 1447 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--AEVELA 1504
Query: 233 SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSR 292
SR ++ + + +++RL + + + L +V+ VQ+ + +
Sbjct: 1505 SRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAE 1563
Query: 293 HEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEA 330
+ K+ + EK + + Q H + LR+EA
Sbjct: 1564 LQSKRASFAEKTAQLERSLQE-----EHVAVAQLREEA 1596
Score = 42.0 bits (97), Expect = 0.002
Identities = 89/382 (23%), Positives = 152/382 (39%), Gaps = 64/382 (16%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
E ++ E++ +LLE L E + E R E ++ ++E R
Sbjct: 1707 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1766
Query: 126 LVD----RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLSRE 176
+ RL+AE R ++ E +L+ L AKR RQ EE R R+ E
Sbjct: 1767 TSEKSKQRLEAEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAE 1823
Query: 177 MLETGPEAERLE--------QLESGEEELV-LAEYESDEEKKVASRVDEDEDDLEEEHIT 227
L EA RL+ + E+ E L LAE E+ + +++ + + + D+EE
Sbjct: 1824 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE---- 1879
Query: 228 KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSL---------GSV 278
+LAQ + + S + LV RQ V E++ +L G
Sbjct: 1880 ----------RLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1928
Query: 279 QL------INDRCVDMQRSRHE-------KKKGAEEEKPKRRRQEKQAACPFYNHEQMGL 325
+L I D RS+ + +++ A EE+ +RR E++ E+
Sbjct: 1929 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1988
Query: 326 LRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATR-QAAGIR 384
R AL EV E+L A +EAR + + QL Q L A + A ++
Sbjct: 1989 QRKAALEEV---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2045
Query: 385 LQDQVV--IIDEAHNLIDTITG 404
++Q + + + +++D + G
Sbjct: 2046 QKEQELQQTLQQEQSVLDQLRG 2067
Score = 40.4 bits (93), Expect = 0.007
Identities = 46/211 (21%), Positives = 85/211 (40%), Gaps = 19/211 (9%)
Query: 120 KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE--------RENLL 171
K EE+ + R AEQ KQR+ Q R+ + RLR E E+ E L
Sbjct: 1664 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1723
Query: 172 RLSREMLETGPEAERLE----QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
RL RE + + LE ++ + E L+ ++ ++EE + S + + E
Sbjct: 1724 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1783
Query: 228 KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC-- 285
++ + ++L E K+ + + + E + ++G +
Sbjct: 1784 EL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1840
Query: 286 --VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
+ + ++ AE+E +RRR E+QAA
Sbjct: 1841 ALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1871
Score = 37.4 bits (85), Expect = 0.060
Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 25/194 (12%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2444 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2503
Query: 123 ERDLVDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
+ + KA+Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2504 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2557
Query: 182 PEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR-THSQLA 240
E ++LEQ +EEL+ E + R+ E LEE+H + + T SQ+A
Sbjct: 2558 -ELQQLEQQRRQQEELLAEENQ---------RLREQLQLLEEQHRAALAHSEEVTASQVA 2607
Query: 241 QFVHEVKKSPFGKD 254
K P G+D
Sbjct: 2608 ----ATKTLPNGRD 2617
Score = 33.9 bits (76), Expect = 0.66
Identities = 62/292 (21%), Positives = 108/292 (36%), Gaps = 39/292 (13%)
Query: 62 LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSS------SCEGAAGTPRPAG-EPAWV 114
++D Q+KR+ E L +++ L + E A R A E A
Sbjct: 1489 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1548
Query: 115 TQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKY-AAKRLRQEEEER-ENLLR 172
Q + +R L Q++R E+ QL+ +Q ++ A +LR+E E R +
Sbjct: 1549 VQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE 1605
Query: 173 LSREMLETGPEAERLE-----------QLESGEEELVLAEYESDEEKKVASRVDEDEDDL 221
R E E ER + Q E ++ LA+ E++++K+ A R
Sbjct: 1606 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1665
Query: 222 EEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
EE+ + + + + Q + + L+ L + E + QL+
Sbjct: 1666 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-------ETEQGEQQRQLL 1718
Query: 282 NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAE 333
+ +QR E ++RQE +A E LL +A AE
Sbjct: 1719 EEELARLQR---------EAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1761
Score = 33.9 bits (76), Expect = 0.66
Identities = 75/391 (19%), Positives = 141/391 (36%), Gaps = 48/391 (12%)
Query: 59 LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
L+ LR + E + L+E ++E L L +S E AA AG+
Sbjct: 1881 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1928
Query: 119 QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
L+ E R + E + + + +L+ A +R EEER R
Sbjct: 1929 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1978
Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
E E Q ++ EE+ + + +E +++ R +++ S Q
Sbjct: 1979 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE---------------SARQLQ 2023
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNL--CVNEDVKSLGSVQLINDRCVDMQRSRHEKK 296
LAQ + + K Q L + ++ L ++ + E +
Sbjct: 2024 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2083
Query: 297 KGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSR 356
AE E + RRQ ++A + E+ R +A A + + + RA +
Sbjct: 2084 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2143
Query: 357 LAIPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTITGMHSVEVS 411
AA + ++ RQ A + L+ Q+ D NL+D + ++
Sbjct: 2144 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAE 2201
Query: 412 GSQLCQAHSQLLQYVERYGKRLKAKNLMYLK 442
++ + SQ+ + E + R++ + L LK
Sbjct: 2202 ATEAARQRSQVEE--ELFSVRVQMEELSKLK 2230
Score = 32.3 bits (72), Expect = 1.9
Identities = 24/97 (24%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
+EE L ++ +AE+ R E + Q ++ +A + + E E +E R+ E++
Sbjct: 1331 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1390
Query: 181 GPEA-ERLEQLESGEEELVLAEYESDEEKKVASRVDE 216
A + +Q S +EEL S+ E + +R E
Sbjct: 1391 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1427
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 48.5 bits (114), Expect = 3e-05
Identities = 72/284 (25%), Positives = 120/284 (42%), Gaps = 35/284 (12%)
Query: 71 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1478 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1537
Query: 125 -----DLVDRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
+L R+KAE ++++ LQ L+ R+Q + A +RLRQ E ER ++++ E
Sbjct: 1538 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1597
Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
+ EAE L+S + A + + E L+EEH+ + +
Sbjct: 1598 QRSAEAE----LQS-------------KRASFAEKTAQLERSLQEEHVA-VAQLREEAER 1639
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
AQ E +++ + L R L NE ++ + + + Q ++K+
Sbjct: 1640 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1695
Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
AE E +R + E+QA EQ L + LAE ++L A
Sbjct: 1696 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1738
Score = 45.1 bits (105), Expect = 3e-04
Identities = 80/376 (21%), Positives = 154/376 (40%), Gaps = 40/376 (10%)
Query: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2284 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2343
Query: 128 DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
++ E R K E LQQ + Q + A+RL++++E+ L + + EAER
Sbjct: 2344 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400
Query: 188 EQLESGEE---------ELVLAEYESDEE----KKVASRVDEDEDDLEEEHITKIYYCSR 234
QLE E E+ A+ ++E+ +K A + E E K+
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2460
Query: 235 THSQLAQFVH------------EVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIN 282
Q Q H E +K ++ +L+ L S + V ++ + L Q +
Sbjct: 2461 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQ 2519
Query: 283 DRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDMEQL 340
+ + S ++++ E+EK K + Q++ A EQ R + E ++ ++L
Sbjct: 2520 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQRL 2575
Query: 341 LALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLI 399
+A +EAR + + +L L Q RL++Q+ +++E H
Sbjct: 2576 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR-- 2633
Query: 400 DTITGMHSVEVSGSQL 415
HS EV+ SQ+
Sbjct: 2634 --AALAHSEEVTASQV 2647
Score = 42.4 bits (98), Expect = 0.002
Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 32/278 (11%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1379 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1427
Query: 126 LVDRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
+V R +A Q +++ +E LQQL+ + + AK RLR EEE R L+
Sbjct: 1428 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1487
Query: 173 LSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYC 232
L + G L+ L + EE + ++ EE + R +DE + + ++
Sbjct: 1488 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--AEVELA 1545
Query: 233 SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSR 292
SR ++ + + +++RL + + + L +V+ VQ+ + +
Sbjct: 1546 SRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAE 1604
Query: 293 HEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEA 330
+ K+ + EK + + Q H + LR+EA
Sbjct: 1605 LQSKRASFAEKTAQLERSLQE-----EHVAVAQLREEA 1637
Score = 42.0 bits (97), Expect = 0.002
Identities = 89/382 (23%), Positives = 152/382 (39%), Gaps = 64/382 (16%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
E ++ E++ +LLE L E + E R E ++ ++E R
Sbjct: 1748 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1807
Query: 126 LVD----RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLSRE 176
+ RL+AE R ++ E +L+ L AKR RQ EE R R+ E
Sbjct: 1808 TSEKSKQRLEAEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAE 1864
Query: 177 MLETGPEAERLE--------QLESGEEELV-LAEYESDEEKKVASRVDEDEDDLEEEHIT 227
L EA RL+ + E+ E L LAE E+ + +++ + + + D+EE
Sbjct: 1865 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE---- 1920
Query: 228 KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSL---------GSV 278
+LAQ + + S + LV RQ V E++ +L G
Sbjct: 1921 ----------RLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1969
Query: 279 QL------INDRCVDMQRSRHE-------KKKGAEEEKPKRRRQEKQAACPFYNHEQMGL 325
+L I D RS+ + +++ A EE+ +RR E++ E+
Sbjct: 1970 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2029
Query: 326 LRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATR-QAAGIR 384
R AL EV E+L A +EAR + + QL Q L A + A ++
Sbjct: 2030 QRKAALEEV---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2086
Query: 385 LQDQVV--IIDEAHNLIDTITG 404
++Q + + + +++D + G
Sbjct: 2087 QKEQELQQTLQQEQSVLDQLRG 2108
Score = 40.4 bits (93), Expect = 0.007
Identities = 46/211 (21%), Positives = 85/211 (40%), Gaps = 19/211 (9%)
Query: 120 KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE--------RENLL 171
K EE+ + R AEQ KQR+ Q R+ + RLR E E+ E L
Sbjct: 1705 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1764
Query: 172 RLSREMLETGPEAERLE----QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
RL RE + + LE ++ + E L+ ++ ++EE + S + + E
Sbjct: 1765 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1824
Query: 228 KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC-- 285
++ + ++L E K+ + + + E + ++G +
Sbjct: 1825 EL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1881
Query: 286 --VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
+ + ++ AE+E +RRR E+QAA
Sbjct: 1882 ALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1912
Score = 37.4 bits (85), Expect = 0.060
Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 25/194 (12%)
Query: 66 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2485 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2544
Query: 123 ERDLVDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
+ + KA+Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2545 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2598
Query: 182 PEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR-THSQLA 240
E ++LEQ +EEL+ E + R+ E LEE+H + + T SQ+A
Sbjct: 2599 -ELQQLEQQRRQQEELLAEENQ---------RLREQLQLLEEQHRAALAHSEEVTASQVA 2648
Query: 241 QFVHEVKKSPFGKD 254
K P G+D
Sbjct: 2649 ----ATKTLPNGRD 2658
Score = 33.9 bits (76), Expect = 0.66
Identities = 62/292 (21%), Positives = 108/292 (36%), Gaps = 39/292 (13%)
Query: 62 LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSS------SCEGAAGTPRPAG-EPAWV 114
++D Q+KR+ E L +++ L + E A R A E A
Sbjct: 1530 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1589
Query: 115 TQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKY-AAKRLRQEEEER-ENLLR 172
Q + +R L Q++R E+ QL+ +Q ++ A +LR+E E R +
Sbjct: 1590 VQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE 1646
Query: 173 LSREMLETGPEAERLE-----------QLESGEEELVLAEYESDEEKKVASRVDEDEDDL 221
R E E ER + Q E ++ LA+ E++++K+ A R
Sbjct: 1647 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1706
Query: 222 EEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
EE+ + + + + Q + + L+ L + E + QL+
Sbjct: 1707 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-------ETEQGEQQRQLL 1759
Query: 282 NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAE 333
+ +QR E ++RQE +A E LL +A AE
Sbjct: 1760 EEELARLQR---------EAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1802
Score = 33.9 bits (76), Expect = 0.66
Identities = 75/391 (19%), Positives = 141/391 (36%), Gaps = 48/391 (12%)
Query: 59 LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
L+ LR + E + L+E ++E L L +S E AA AG+
Sbjct: 1922 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1969
Query: 119 QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
L+ E R + E + + + +L+ A +R EEER R
Sbjct: 1970 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 2019
Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
E E Q ++ EE+ + + +E +++ R +++ S Q
Sbjct: 2020 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE---------------SARQLQ 2064
Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNL--CVNEDVKSLGSVQLINDRCVDMQRSRHEKK 296
LAQ + + K Q L + ++ L ++ + E +
Sbjct: 2065 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2124
Query: 297 KGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSR 356
AE E + RRQ ++A + E+ R +A A + + + RA +
Sbjct: 2125 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2184
Query: 357 LAIPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTITGMHSVEVS 411
AA + ++ RQ A + L+ Q+ D NL+D + ++
Sbjct: 2185 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAE 2242
Query: 412 GSQLCQAHSQLLQYVERYGKRLKAKNLMYLK 442
++ + SQ+ + E + R++ + L LK
Sbjct: 2243 ATEAARQRSQVEE--ELFSVRVQMEELSKLK 2271
Score = 32.3 bits (72), Expect = 1.9
Identities = 24/97 (24%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
+EE L ++ +AE+ R E + Q ++ +A + + E E +E R+ E++
Sbjct: 1372 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1431
Query: 181 GPEA-ERLEQLESGEEELVLAEYESDEEKKVASRVDE 216
A + +Q S +EEL S+ E + +R E
Sbjct: 1432 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1468
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,168,791
Number of Sequences: 37866
Number of extensions: 1502077
Number of successful extensions: 14098
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 182
Number of HSP's successfully gapped in prelim test: 609
Number of HSP's that attempted gapping in prelim test: 8400
Number of HSP's gapped (non-prelim): 3394
length of query: 856
length of database: 18,247,518
effective HSP length: 111
effective length of query: 745
effective length of database: 14,044,392
effective search space: 10463072040
effective search space used: 10463072040
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.