Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 100913204

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|100913204 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
isoform 2 [Homo sapiens]
         (856 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|100913204 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 iso...  1682   0.0  
gi|100913202 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 iso...  1659   0.0  
gi|212549538 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12 [Ho...  1621   0.0  
gi|132566527 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 iso...  1492   0.0  
gi|239755744 PREDICTED: similar to Putative ATP-dependent RNA he...   338   2e-92
gi|239755742 PREDICTED: similar to DEAD/H (Asp-Glu-Ala-Asp/His) ...   317   3e-86
gi|14042978 BRCA1 interacting protein C-terminal helicase 1 [Hom...   211   2e-54
gi|91984775 regulator of telomere elongation helicase 1 isoform ...   187   5e-47
gi|7706541 regulator of telomere elongation helicase 1 isoform 1...   187   5e-47
gi|15834617 excision repair cross-complementing rodent repair de...   113   9e-25
gi|195947407 excision repair cross-complementing rodent repair d...    67   5e-11
gi|239743668 PREDICTED: hypothetical protein XP_002342944 [Homo ...    59   1e-08
gi|239745348 PREDICTED: hypothetical protein XP_002343431 [Homo ...    59   3e-08
gi|239740967 PREDICTED: hypothetical protein XP_002342051 [Homo ...    59   3e-08
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           52   3e-06
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           52   3e-06
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           52   3e-06
gi|119120918 coiled-coil domain containing 64 [Homo sapiens]           51   5e-06
gi|148746195 trichohyalin [Homo sapiens]                               50   7e-06
gi|22758136 MAP7 domain containing 2 [Homo sapiens]                    50   9e-06
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    49   2e-05
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    49   2e-05
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        49   3e-05
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        49   3e-05
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         49   3e-05
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         49   3e-05
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         49   3e-05
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         49   3e-05
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         49   3e-05
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         49   3e-05

>gi|100913204 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
           isoform 2 [Homo sapiens]
          Length = 856

 Score = 1682 bits (4356), Expect = 0.0
 Identities = 856/856 (100%), Positives = 856/856 (100%)

Query: 1   MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
           MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS
Sbjct: 1   MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60

Query: 61  WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
           WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK
Sbjct: 61  WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120

Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
           KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET
Sbjct: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180

Query: 181 GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA 240
           GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA
Sbjct: 181 GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA 240

Query: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE 300
           QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE
Sbjct: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE 300

Query: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
           EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP
Sbjct: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360

Query: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS 420
           AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS
Sbjct: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS 420

Query: 421 QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND 480
           QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND
Sbjct: 421 QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND 480

Query: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
           FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR
Sbjct: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540

Query: 541 TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
           TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL
Sbjct: 541 TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600

Query: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
           NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP
Sbjct: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660

Query: 661 LVICSGISNQPLEFTFQKRELPQMIFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGAL 720
           LVICSGISNQPLEFTFQKRELPQMIFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGAL
Sbjct: 661 LVICSGISNQPLEFTFQKRELPQMIFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGAL 720

Query: 721 LLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGK 780
           LLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGK
Sbjct: 721 LLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGK 780

Query: 781 ALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGP 840
           ALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGP
Sbjct: 781 ALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGP 840

Query: 841 AIAAVQKFHREKSASS 856
           AIAAVQKFHREKSASS
Sbjct: 841 AIAAVQKFHREKSASS 856


>gi|100913202 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
           isoform 1 [Homo sapiens]
          Length = 906

 Score = 1659 bits (4295), Expect = 0.0
 Identities = 856/906 (94%), Positives = 856/906 (94%), Gaps = 50/906 (5%)

Query: 1   MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
           MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS
Sbjct: 1   MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60

Query: 61  WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
           WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK
Sbjct: 61  WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120

Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
           KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET
Sbjct: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180

Query: 181 GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA 240
           GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA
Sbjct: 181 GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA 240

Query: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE 300
           QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE
Sbjct: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE 300

Query: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
           EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP
Sbjct: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360

Query: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS 420
           AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS
Sbjct: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS 420

Query: 421 QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND 480
           QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND
Sbjct: 421 QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND 480

Query: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
           FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR
Sbjct: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540

Query: 541 TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
           TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL
Sbjct: 541 TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600

Query: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
           NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP
Sbjct: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660

Query: 661 LVICSGISNQPLEFTFQKRELPQM------------------------------------ 684
           LVICSGISNQPLEFTFQKRELPQM                                    
Sbjct: 661 LVICSGISNQPLEFTFQKRELPQMMDEVGRILCNLCGVVPGGVVCFFPSYEYLRQVHAHW 720

Query: 685 --------------IFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMS 730
                         IFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMS
Sbjct: 721 EKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMS 780

Query: 731 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKA 790
           EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKA
Sbjct: 781 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKA 840

Query: 791 VNQSIGRAIRHQKDFASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 850
           VNQSIGRAIRHQKDFASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR
Sbjct: 841 VNQSIGRAIRHQKDFASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 900

Query: 851 EKSASS 856
           EKSASS
Sbjct: 901 EKSASS 906


>gi|212549538 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12 [Homo
           sapiens]
          Length = 906

 Score = 1621 bits (4197), Expect = 0.0
 Identities = 835/906 (92%), Positives = 847/906 (93%), Gaps = 50/906 (5%)

Query: 1   MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
           MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS
Sbjct: 1   MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60

Query: 61  WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
           WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK
Sbjct: 61  WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120

Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
           KEERDLV+RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET
Sbjct: 121 KEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180

Query: 181 GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA 240
           GPEAER EQLESGEEELVLAEYESDEEKKVAS VDEDEDDLEEEHITKIY+CSRTHSQLA
Sbjct: 181 GPEAERPEQLESGEEELVLAEYESDEEKKVASGVDEDEDDLEEEHITKIYHCSRTHSQLA 240

Query: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE 300
           QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDV+SLGSVQLIN+RCVDMQRSRHEKKKGAE
Sbjct: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINNRCVDMQRSRHEKKKGAE 300

Query: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
           EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP
Sbjct: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360

Query: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS 420
           AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDT T MHSVEVSGSQLCQAHS
Sbjct: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTTTSMHSVEVSGSQLCQAHS 420

Query: 421 QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND 480
           QLLQY+ERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTG ELKTIND
Sbjct: 421 QLLQYMERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGMELKTIND 480

Query: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
           FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR
Sbjct: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540

Query: 541 TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
           TTEALAAPADESQAS  +PASPLMHI+GFLAALTTANQDGRVILSRQGSLSQSTLKFLLL
Sbjct: 541 TTEALAAPADESQASVPQPASPLMHIEGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600

Query: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
           NPAVHFAQVVKECRAVVIAGGTMQPVS+FRQQLLACAGVEAERVVEFSCGHVIPPDNILP
Sbjct: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSNFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660

Query: 661 LVICSGISNQPLEFTFQKRELPQM------------------------------------ 684
           LVICSG+SNQPLEFTFQKR+LPQM                                    
Sbjct: 661 LVICSGVSNQPLEFTFQKRDLPQMMDEVGRILCNLCGVVSGGVVCFFPSYEYLRQVHAHW 720

Query: 685 --------------IFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMS 730
                         IFQEPKSAHQVEQVLLAYSRC+QACGQERG VTGALLLSVVGGKMS
Sbjct: 721 EKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCLQACGQERGPVTGALLLSVVGGKMS 780

Query: 731 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKA 790
           EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQA PGKALVENLCMKA
Sbjct: 781 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAHPGKALVENLCMKA 840

Query: 791 VNQSIGRAIRHQKDFASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 850
           VNQSIGRAIRHQKDFAS+VLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR
Sbjct: 841 VNQSIGRAIRHQKDFASIVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 900

Query: 851 EKSASS 856
           EKSASS
Sbjct: 901 EKSASS 906


>gi|132566527 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
           isoform 3 [Homo sapiens]
          Length = 970

 Score = 1492 bits (3863), Expect = 0.0
 Identities = 772/829 (93%), Positives = 772/829 (93%), Gaps = 50/829 (6%)

Query: 1   MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60
           MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS
Sbjct: 1   MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS 60

Query: 61  WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120
           WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK
Sbjct: 61  WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK 120

Query: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
           KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET
Sbjct: 121 KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180

Query: 181 GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA 240
           GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA
Sbjct: 181 GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA 240

Query: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE 300
           QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE
Sbjct: 241 QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE 300

Query: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360
           EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP
Sbjct: 301 EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP 360

Query: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS 420
           AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS
Sbjct: 361 AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS 420

Query: 421 QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND 480
           QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND
Sbjct: 421 QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND 480

Query: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540
           FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR
Sbjct: 481 FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR 540

Query: 541 TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600
           TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL
Sbjct: 541 TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL 600

Query: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660
           NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP
Sbjct: 601 NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP 660

Query: 661 LVICSGISNQPLEFTFQKRELPQM------------------------------------ 684
           LVICSGISNQPLEFTFQKRELPQM                                    
Sbjct: 661 LVICSGISNQPLEFTFQKRELPQMMDEVGRILCNLCGVVPGGVVCFFPSYEYLRQVHAHW 720

Query: 685 --------------IFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMS 730
                         IFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMS
Sbjct: 721 EKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMS 780

Query: 731 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPG 779
           EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTL   PG    G
Sbjct: 781 EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLSPRPGTPREG 829


>gi|239755744 PREDICTED: similar to Putative ATP-dependent RNA
           helicase DDX11-like protein [Homo sapiens]
          Length = 223

 Score =  338 bits (866), Expect = 2e-92
 Identities = 170/172 (98%), Positives = 171/172 (99%)

Query: 685 IFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMSEGINFSDNLGRCVV 744
           IFQEPKSAHQVEQVLLAYSRCIQACGQERGQVT ALLLSVVGGKMSEGINFSDNLGRCVV
Sbjct: 52  IFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTEALLLSVVGGKMSEGINFSDNLGRCVV 111

Query: 745 MVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKAVNQSIGRAIRHQKD 804
           MVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKAVNQSIGRAIRHQKD
Sbjct: 112 MVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKAVNQSIGRAIRHQKD 171

Query: 805 FASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHREKSASS 856
           FAS+VLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHREKSASS
Sbjct: 172 FASIVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHREKSASS 223


>gi|239755742 PREDICTED: similar to DEAD/H (Asp-Glu-Ala-Asp/His) box
           polypeptide 11 (CHL1-like helicase homolog, S.
           cerevisiae) [Homo sapiens]
          Length = 282

 Score =  317 bits (812), Expect = 3e-86
 Identities = 162/173 (93%), Positives = 163/173 (94%)

Query: 45  PTGTGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT 104
           P   GKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT
Sbjct: 39  PAKKGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT 98

Query: 105 PRPAGEPAWVTQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEE 164
           PRPAGEPAWVTQFVQKKEERDLV+RLK EQARRKQREERLQQLQHRVQLKYAAKRLRQEE
Sbjct: 99  PRPAGEPAWVTQFVQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEE 158

Query: 165 EERENLLRLSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDED 217
           EE ENLLRLSREMLETGPEAE LEQLESGEEELVLAEYESDEEKKVAS    D
Sbjct: 159 EETENLLRLSREMLETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGAPSD 211


>gi|14042978 BRCA1 interacting protein C-terminal helicase 1 [Homo
           sapiens]
          Length = 1249

 Score =  211 bits (538), Expect = 2e-54
 Identities = 218/937 (23%), Positives = 407/937 (43%), Gaps = 152/937 (16%)

Query: 8   VGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQ 67
           +G +   FP+  Y  Q   M  + R L + +  + ESPTG+GKSL+L+C AL+W +    
Sbjct: 10  IGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSG 69

Query: 68  KKREEEARLLETGTGPLHDEKDESLCLSSSCEGA--------AGTPR-------PAGEPA 112
           K  +E           + ++ +  L    +C            GT R       P  E  
Sbjct: 70  KPADEG----------VSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPSTPPSERN 119

Query: 113 WVTQFVQKKEERD-LVDRLKAEQARRKQREER--LQQLQHRVQLKYAAKRLRQEEEEREN 169
             +   Q   E+  L  +L A++     R+E    Q  + R++     +++R+       
Sbjct: 120 GTSSTCQDSPEKTTLAAKLSAKKQASIYRDENDDFQVEKKRIRPLETTQQIRKRHCFGTE 179

Query: 170 LLRLSREMLETGPEAER---LEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEH- 225
           +  L  ++ ++G   +    LE++ S   +                   E  + ++++H 
Sbjct: 180 VHNLDAKV-DSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHT 238

Query: 226 ----ITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
               I KIY+ +RTH Q+AQ   E++++ +   V +  L SR + CV+ +V  +G+    
Sbjct: 239 GKSKIPKIYFGTRTHKQIAQITRELRRTAYS-GVPMTILSSRDHTCVHPEV--VGNFNR- 294

Query: 282 NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYN-----HEQMGLLRDEALAEVKD 336
           N++C+++   ++ K                  +C FY+      +Q  L   + + +  D
Sbjct: 295 NEKCMELLDGKNGK------------------SCYFYHGVHKISDQHTLQTFQGMCKAWD 336

Query: 337 MEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAH 396
           +E+L++LGK+ +ACPYY +R  I  A ++  PY  LL A  R++  + L++QVVI+DEAH
Sbjct: 337 IEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAH 396

Query: 397 NLIDTITGMHSVEVSGSQLCQAHSQLLQYVERYGKRLKAKNLMYLKQI-LYLLEKFVAVL 455
           N+ D      S  V+  QL  A  +L   V      ++ K+   L+ +   L+    A  
Sbjct: 397 NIEDCARESASYSVTEVQLRFARDELDSMV---NNNIRKKDHEPLRAVCCSLINWLEANA 453

Query: 456 GGNIKQNPNTQSLSQTGTE-LKTINDFLFQSQIDNINLFKVQRYCEKSMISRKLFGFTE- 513
              ++++  +     +G E L T++     +    I         +K      ++G  E 
Sbjct: 454 EYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEA 513

Query: 514 RYGAVFSSREQPKLAGFQQFLQSLQPRTTEALAAPADESQASTLRPASPLMHIQGFLAAL 573
           R   V S+  Q  L G    L  L  + +      AD+ + +       +     +   +
Sbjct: 514 REVPVISASTQIMLKGLFMVLDYLFRQNSRF----ADDYKIA-------IQQTYSWTNQI 562

Query: 574 TTANQDGRVILSRQGSLSQS-----TLKFLLLNPAVHFAQVVKECRAVVIAGGTMQPVSD 628
             ++++G ++L +    S+       L F  LNPAV F+ +  + + +V+  GT+ P+  
Sbjct: 563 DISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKS 622

Query: 629 FRQQLLACAGVEAERVVEFSCGHVIPPDNILPLVICSGISNQPLEFTFQKR--------- 679
           F  +L    GV     ++    H+I    +    I SG   + L  TFQ           
Sbjct: 623 FSSEL----GVTF--TIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEV 676

Query: 680 -----------------------------------------ELPQMIFQEPKSAHQV--E 696
                                                    EL + +  EP+   +   +
Sbjct: 677 GALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFD 736

Query: 697 QVLLAYSRCIQACGQERGQVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSA 756
           ++L  Y   I    + +G+  GALL++V  GK+SEG++FSD+  R V+ +G+PFPN++  
Sbjct: 737 ELLQVYYDAI----KYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDL 792

Query: 757 ELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRYA 816
           +++ K  Y D    +  G   PG+   E    +A+NQ++GR IRH+ D+ +++L+D R+ 
Sbjct: 793 QVELKRQYNDHH-SKLRGLL-PGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFR 850

Query: 817 RPP--VLAKLPAWIRARVEVKATFGPAIAAVQKFHRE 851
             P   ++ L  W+R +++  +TF  A+ ++ +F ++
Sbjct: 851 NNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKK 887


>gi|91984775 regulator of telomere elongation helicase 1 isoform 2
           [Homo sapiens]
          Length = 1300

 Score =  187 bits (474), Expect = 5e-47
 Identities = 178/695 (25%), Positives = 298/695 (42%), Gaps = 120/695 (17%)

Query: 226 ITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC 285
           I KI Y SRTHSQL Q ++E++ + +   V +  LGSR+ LC++ +VK   S  L    C
Sbjct: 106 IPKIIYASRTHSQLTQVINELRNTSYRPKVCV--LGSREQLCIHPEVKKQESNHLQIHLC 163

Query: 286 VDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGK 345
                                R++    +C FYN+ +   L  E  + + D+E L+  G 
Sbjct: 164 ---------------------RKKVASRSCHFYNNVEEKSLEQELASPILDIEDLVKSGS 202

Query: 346 EARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNL------- 398
           + R CPYY SR     A ++ +PY  LL A +R+A  I L+  VVI DEAHN+       
Sbjct: 203 KHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDLKGTVVIFDEAHNVEKMCEES 262

Query: 399 -------------IDTITGMHSVEVSGSQLCQAHSQLLQYVERYGKRLKAKNLMYLKQIL 445
                        +D I  +   +   +Q  + H +        G  ++ +++  LK IL
Sbjct: 263 ASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFSADSPSPGLNMELEDIAKLKMIL 322

Query: 446 YLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTINDFLFQSQIDNINLFKVQRYCEKSMIS 505
             LE  +      ++   +   +++ G+       ++F+   +    F+ +  C    + 
Sbjct: 323 LRLEGAIDA----VELPGDDSGVTKPGS-------YIFELFAEAQITFQTKG-CILDSLD 370

Query: 506 RKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPRTTEALAAPADESQASTLRPASPLMH 565
           + +     R G   ++    KLA   Q + S+ P       +P   +    L+  S  +H
Sbjct: 371 QIIQHLAGRAGVFTNTAGLQKLADIIQIVFSVDPSE----GSPGSPAGLGALQ--SYKVH 424

Query: 566 IQGFLAALTTANQD---GRVILSRQGSLSQSTLKFLLLNPAVHFAQVVKE-CRAVVIAGG 621
           I        TA +          ++G +    L +   +P     ++V++  R++++  G
Sbjct: 425 IHPDAGHRRTAQRSDAWSTTAARKRGKV----LSYWCFSPGHSMHELVRQGVRSLILTSG 480

Query: 622 TMQPVSDF--RQQLLACAGVEAERVVE-------------------------FS------ 648
           T+ PVS F    Q+     +E   +++                         FS      
Sbjct: 481 TLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSS 540

Query: 649 ----CGHV--IPPDNILPLVICSGISNQPLEF-----TFQKRELPQMIFQEPKSAHQVEQ 697
                G++  + P  +L       +  + LEF       +K E  + +F EP+S     +
Sbjct: 541 LGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRSKGSFSE 600

Query: 698 VLLAYSRCIQACGQERGQVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAE 757
            + AY   + A G      TGA  L+V  GK SEG++FSD  GR V++ G+P+P      
Sbjct: 601 TISAYYARVAAPGS-----TGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPR 655

Query: 758 LQEKMAYLDQTLPR--APGQAPPGKALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRY 815
           +  KM +LD+   +  A GQ   G+        +AVNQ+IGR IRH++D+ +V L D R+
Sbjct: 656 VVLKMQFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRF 715

Query: 816 ARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 850
           A     A+LP+W+R  V V   FG  I  V +F R
Sbjct: 716 AFADARAQLPSWVRPHVRVYDNFGHVIRDVAQFFR 750



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 35/94 (37%), Positives = 49/94 (52%), Gaps = 10/94 (10%)

Query: 15  FPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSW---LRDFEQKKRE 71
           FPF PY  Q+++M ++   L+    GI ESPTGTGK+L L+C  L+W   LRD    +  
Sbjct: 13  FPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWREHLRDGISAR-- 70

Query: 72  EEARLLETGTGPLHDEKDESLCLSSSCEGAAGTP 105
              ++ E   G L    D +L    +   AAG P
Sbjct: 71  ---KIAERAQGELF--PDRALSSWGNAAAAAGDP 99


>gi|7706541 regulator of telomere elongation helicase 1 isoform 1
           [Homo sapiens]
          Length = 1219

 Score =  187 bits (474), Expect = 5e-47
 Identities = 178/695 (25%), Positives = 298/695 (42%), Gaps = 120/695 (17%)

Query: 226 ITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC 285
           I KI Y SRTHSQL Q ++E++ + +   V +  LGSR+ LC++ +VK   S  L    C
Sbjct: 106 IPKIIYASRTHSQLTQVINELRNTSYRPKVCV--LGSREQLCIHPEVKKQESNHLQIHLC 163

Query: 286 VDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGK 345
                                R++    +C FYN+ +   L  E  + + D+E L+  G 
Sbjct: 164 ---------------------RKKVASRSCHFYNNVEEKSLEQELASPILDIEDLVKSGS 202

Query: 346 EARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNL------- 398
           + R CPYY SR     A ++ +PY  LL A +R+A  I L+  VVI DEAHN+       
Sbjct: 203 KHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDLKGTVVIFDEAHNVEKMCEES 262

Query: 399 -------------IDTITGMHSVEVSGSQLCQAHSQLLQYVERYGKRLKAKNLMYLKQIL 445
                        +D I  +   +   +Q  + H +        G  ++ +++  LK IL
Sbjct: 263 ASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFSADSPSPGLNMELEDIAKLKMIL 322

Query: 446 YLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTINDFLFQSQIDNINLFKVQRYCEKSMIS 505
             LE  +      ++   +   +++ G+       ++F+   +    F+ +  C    + 
Sbjct: 323 LRLEGAIDA----VELPGDDSGVTKPGS-------YIFELFAEAQITFQTKG-CILDSLD 370

Query: 506 RKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPRTTEALAAPADESQASTLRPASPLMH 565
           + +     R G   ++    KLA   Q + S+ P       +P   +    L+  S  +H
Sbjct: 371 QIIQHLAGRAGVFTNTAGLQKLADIIQIVFSVDPSE----GSPGSPAGLGALQ--SYKVH 424

Query: 566 IQGFLAALTTANQD---GRVILSRQGSLSQSTLKFLLLNPAVHFAQVVKE-CRAVVIAGG 621
           I        TA +          ++G +    L +   +P     ++V++  R++++  G
Sbjct: 425 IHPDAGHRRTAQRSDAWSTTAARKRGKV----LSYWCFSPGHSMHELVRQGVRSLILTSG 480

Query: 622 TMQPVSDF--RQQLLACAGVEAERVVE-------------------------FS------ 648
           T+ PVS F    Q+     +E   +++                         FS      
Sbjct: 481 TLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSS 540

Query: 649 ----CGHV--IPPDNILPLVICSGISNQPLEF-----TFQKRELPQMIFQEPKSAHQVEQ 697
                G++  + P  +L       +  + LEF       +K E  + +F EP+S     +
Sbjct: 541 LGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRSKGSFSE 600

Query: 698 VLLAYSRCIQACGQERGQVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAE 757
            + AY   + A G      TGA  L+V  GK SEG++FSD  GR V++ G+P+P      
Sbjct: 601 TISAYYARVAAPGS-----TGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPR 655

Query: 758 LQEKMAYLDQTLPR--APGQAPPGKALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRY 815
           +  KM +LD+   +  A GQ   G+        +AVNQ+IGR IRH++D+ +V L D R+
Sbjct: 656 VVLKMQFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRF 715

Query: 816 ARPPVLAKLPAWIRARVEVKATFGPAIAAVQKFHR 850
           A     A+LP+W+R  V V   FG  I  V +F R
Sbjct: 716 AFADARAQLPSWVRPHVRVYDNFGHVIRDVAQFFR 750



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 35/94 (37%), Positives = 49/94 (52%), Gaps = 10/94 (10%)

Query: 15  FPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSW---LRDFEQKKRE 71
           FPF PY  Q+++M ++   L+    GI ESPTGTGK+L L+C  L+W   LRD    +  
Sbjct: 13  FPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWREHLRDGISAR-- 70

Query: 72  EEARLLETGTGPLHDEKDESLCLSSSCEGAAGTP 105
              ++ E   G L    D +L    +   AAG P
Sbjct: 71  ---KIAERAQGELF--PDRALSSWGNAAAAAGDP 99


>gi|15834617 excision repair cross-complementing rodent repair
           deficiency, complementation group 2 protein isoform 1
           [Homo sapiens]
          Length = 760

 Score =  113 bits (282), Expect = 9e-25
 Identities = 161/715 (22%), Positives = 284/715 (39%), Gaps = 139/715 (19%)

Query: 226 ITKIYYCSRTHSQLAQFVHEVKK------SPFGKDVRLV--SLGSRQNLCVNEDVKSLGS 277
           +TK+ YCSRT  ++ + + E++K         G+ +  +  +L SR+NLC++ +V  L  
Sbjct: 67  VTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRF 126

Query: 278 VQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDM 337
            + ++ +C  +  S    +   +   P          C FY             A + ++
Sbjct: 127 GKDVDGKCHSLTASYVRAQYQHDTSLPH---------CRFYEEFDAHGREVPLPAGIYNL 177

Query: 338 EQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRL-QDQVVIIDEAH 396
           + L ALG+    CPY+ +R +I  A +VV  Y  LL           L +  VV+ DEAH
Sbjct: 178 DDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAH 237

Query: 397 NLIDTITGMHSVEVSGSQL--CQAHSQLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAV 454
           N+ +      SV ++   L  CQ +   L+ +++   R+K  +   L+      +++  +
Sbjct: 238 NIDNVCIDSMSVNLTRRTLDRCQGN---LETLQKTVLRIKETDEQRLR------DEYRRL 288

Query: 455 LGGNIKQNPNTQSLSQTGTELKTINDFLFQSQIDNINLFKVQRYCEKSMISRKLFGFTER 514
           + G  + +   ++ +     +  + D + Q  +   ++   + +     + R L     R
Sbjct: 289 VEGLREASAARETDAHLANPV--LPDEVLQEAVPG-SIRTAEHFL--GFLRRLLEYVKWR 343

Query: 515 YGAVFSSREQPKLAGFQQFLQSLQPRT----------TEALAAPADESQASTLRPASPLM 564
                  +E P       FL  L  R            E L +     + + L   SPL 
Sbjct: 344 LRVQHVVQESPPA-----FLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLT 398

Query: 565 HIQGFLAALTTANQDGRVILS----RQGSLSQSTLKFLLLNPAVHFAQVVKECRAVVIAG 620
            +  F   ++T  +   +I+     R  +++   L F  ++ ++    V +  ++V+I  
Sbjct: 399 LLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITS 458

Query: 621 GTMQPVS------DFRQQLLACAGVEAERVVEFSCGHVIPPDNILPLVICSGISNQPLEF 674
           GT+ P+       DF    +A   +   RV             + P++I  G     +  
Sbjct: 459 GTLSPLDIYPKILDFHPVTMATFTMTLARVC------------LCPMIIGRGNDQVAISS 506

Query: 675 TFQKRE------------------LPQMI--------FQEPKSAHQVEQVLL-------- 700
            F+ RE                  +P  I        + E   A   EQ +L        
Sbjct: 507 KFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKL 566

Query: 701 -------------AYSRCIQACGQERGQVTGALLLSVVGGKMSEGINFSDNLGRCVVMVG 747
                        A  +  +AC   RG    A+LLSV  GK+SEGI+F  + GR V+M G
Sbjct: 567 LFIETQDGAETSVALEKYQEACENGRG----AILLSVARGKVSEGIDFVHHYGRAVIMFG 622

Query: 748 MPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKAVNQSIGRAIRHQKDFAS 807
           +P+   +S  L+ ++ YL     R   Q      L  +  M+   Q +GRAIR + D+  
Sbjct: 623 VPYVYTQSRILKARLEYL-----RDQFQIRENDFLTFD-AMRHAAQCVGRAIRGKTDYGL 676

Query: 808 VVLLDQRYARPPVLAKLPAWIR-----ARVEVKATFGPAIA------AVQKFHRE 851
           +V  D+R+AR     KLP WI+     A + +    G  +A        Q FHRE
Sbjct: 677 MVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHRE 731



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 20/55 (36%), Positives = 35/55 (63%), Gaps = 1/55 (1%)

Query: 11 IHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDF 65
          ++FP+ +  Y  Q  +M EL R L+A   G+ E P+GTGK++SL+   +++ R +
Sbjct: 10 VYFPYDYI-YPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAY 63


>gi|195947407 excision repair cross-complementing rodent repair
           deficiency, complementation group 2 protein isoform 2
           [Homo sapiens]
          Length = 405

 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 55/210 (26%), Positives = 95/210 (45%), Gaps = 20/210 (9%)

Query: 226 ITKIYYCSRTHSQLAQFVHEVKK------SPFGKDVRLV--SLGSRQNLCVNEDVKSLGS 277
           +TK+ YCSRT  ++ + + E++K         G+ +  +  +L SR+NLC++ +V  L  
Sbjct: 43  VTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRF 102

Query: 278 VQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDM 337
            + ++ +C  +  S    +   +   P          C FY             A + ++
Sbjct: 103 GKDVDGKCHSLTASYVRAQYQHDTSLPH---------CRFYEEFDAHGREVPLPAGIYNL 153

Query: 338 EQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRL-QDQVVIIDEAH 396
           + L ALG+    CPY+ +R +I  A +VV  Y  LL           L +  VV+ DEAH
Sbjct: 154 DDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAH 213

Query: 397 NLIDTITGMHSVEVSGSQL--CQAHSQLLQ 424
           N+ +      SV ++   L  CQ + + LQ
Sbjct: 214 NIDNVCIDSMSVNLTRRTLDRCQGNLETLQ 243



 Score = 34.7 bits (78), Expect = 0.39
 Identities = 16/39 (41%), Positives = 26/39 (66%)

Query: 27 MAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDF 65
          M EL R L+A   G+ E P+GTGK++SL+   +++ R +
Sbjct: 1  MRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAY 39


>gi|239743668 PREDICTED: hypothetical protein XP_002342944 [Homo
           sapiens]
          Length = 133

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 33/54 (61%), Positives = 35/54 (64%), Gaps = 6/54 (11%)

Query: 729 MSEGINFSDNLG------RCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQA 776
           MSE INFSDNLG      RCVVM GMPFP+IRS ELQ+  A LD  L   P  A
Sbjct: 1   MSESINFSDNLGQLLSPPRCVVMPGMPFPSIRSPELQKTTADLDHNLVSVPSVA 54


>gi|239745348 PREDICTED: hypothetical protein XP_002343431 [Homo
           sapiens]
          Length = 133

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 33/54 (61%), Positives = 35/54 (64%), Gaps = 6/54 (11%)

Query: 729 MSEGINFSDNLG------RCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQA 776
           MSE INFS NLG      RCVVM GMPFP+IRS ELQ+  A LD TL   P  A
Sbjct: 1   MSESINFSHNLGQLLSPPRCVVMPGMPFPSIRSPELQKTTADLDHTLVSVPSVA 54


>gi|239740967 PREDICTED: hypothetical protein XP_002342051 [Homo
           sapiens]
          Length = 133

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 33/54 (61%), Positives = 35/54 (64%), Gaps = 6/54 (11%)

Query: 729 MSEGINFSDNLG------RCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQA 776
           MSE INFS NLG      RCVVM GMPFP+IRS ELQ+  A LD TL   P  A
Sbjct: 1   MSESINFSHNLGQLLSPPRCVVMPGMPFPSIRSPELQKTTADLDHTLVSVPSVA 54


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 60/228 (26%), Positives = 103/228 (45%), Gaps = 40/228 (17%)

Query: 121  KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAK------RLRQEEEERENLLRLS 174
            KE + L DRL    ++  + EE+++ L ++++LKY A       RLR+EE+ R+ L +L 
Sbjct: 1024 KERKLLEDRLAEFSSQAAEEEEKVKSL-NKLRLKYEATIADMEDRLRKEEKGRQELEKLK 1082

Query: 175  R-----------EMLETGPEAERLE-QLESGEEELVLAEYESDEE-----------KKVA 211
            R           +M+E    AE L  QL   EEEL  A   +++E           ++  
Sbjct: 1083 RRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQ 1142

Query: 212  SRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLC---- 267
            + + E ++DLE E + +    ++   Q      E++      +  L S  ++Q L     
Sbjct: 1143 AALAEAQEDLESERVAR----TKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKRE 1198

Query: 268  --VNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQA 313
              V E  K+L     I++  V   R RH +  G   E+ ++ R+ K A
Sbjct: 1199 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGA 1246



 Score = 37.0 bits (84), Expect = 0.078
 Identities = 62/282 (21%), Positives = 104/282 (36%), Gaps = 70/282 (24%)

Query: 128  DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
            D +   +A+  Q+ + LQQ   R ++     R+ Q EEER  L    R   E   EAE  
Sbjct: 876  DEVLQARAQELQKVQELQQQSAR-EVGELQGRVAQLEEERARLAEQLRAEAELCAEAEET 934

Query: 188  E---QLESGEEELVLAEYES-------------DEEKKVASRVDEDEDDLEEEHITKIYY 231
                     E ELV++E E+              E+K++   + E E  LE E       
Sbjct: 935  RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE------ 988

Query: 232  CSRTHSQLAQFVHEVKKSPFGKDVRLVS-----LGSRQNLCVN-------------EDVK 273
             +R   QL +   E K   F +D+ L+      L   + L  +             E VK
Sbjct: 989  GARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVK 1048

Query: 274  SLGSVQL-----------------------------INDRCVDMQRSRHEKKKGAEEEKP 304
            SL  ++L                             ++    ++Q    E+++ AEE + 
Sbjct: 1049 SLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1108

Query: 305  KRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKE 346
            +  R+E++        E  G  R + L  +++ +  LA  +E
Sbjct: 1109 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQE 1150



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 78/334 (23%), Positives = 134/334 (40%), Gaps = 42/334 (12%)

Query: 62   LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGE----PAWVTQF 117
            L D ++  +EE    L  G+     E + +       E AA   R   E     A ++++
Sbjct: 1342 LHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEW 1401

Query: 118  VQKKEERDLVDRLKAEQARRKQRE-----ERLQQLQHRV-QLKYAAKRLRQEEEERENLL 171
             +++EE         E  RR  RE     +RL +    V +L+   +RL+QE ++    L
Sbjct: 1402 RRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL 1461

Query: 172  RLSREMLETGPEAER-LEQLESGEEELVL--------AEYESDEEKKVA---SRVDEDED 219
               R+++ T  + +R  +QL + E+  VL        AE E  E +  A   +R  E+E 
Sbjct: 1462 EQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQ 1521

Query: 220  DLEEE-------HITKIYYCSRTHSQLAQFVHEVKKS-----PFGKDVRLVSLGSRQNLC 267
            +  EE          ++     +   + + VHE++++         D+R         L 
Sbjct: 1522 EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELT 1581

Query: 268  VNEDVKSLGSVQLINDRCVDMQRSRHEKK-KGAEEEKPKRRRQ-EKQAACPFYNHEQMGL 325
              ED K      L  +  V   +++HE+  +G +E   +RRRQ  KQ        ++   
Sbjct: 1582 AAEDAK------LRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERK 1635

Query: 326  LRDEALAEVKDMEQLLALGKEARACPYYGSRLAI 359
             R  A+A  K +E  L   K   A    G   A+
Sbjct: 1636 QRTLAVAARKKLEGELEELKAQMASAGQGKEEAV 1669


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 60/228 (26%), Positives = 103/228 (45%), Gaps = 40/228 (17%)

Query: 121  KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAK------RLRQEEEERENLLRLS 174
            KE + L DRL    ++  + EE+++ L ++++LKY A       RLR+EE+ R+ L +L 
Sbjct: 1016 KERKLLEDRLAEFSSQAAEEEEKVKSL-NKLRLKYEATIADMEDRLRKEEKGRQELEKLK 1074

Query: 175  R-----------EMLETGPEAERLE-QLESGEEELVLAEYESDEE-----------KKVA 211
            R           +M+E    AE L  QL   EEEL  A   +++E           ++  
Sbjct: 1075 RRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQ 1134

Query: 212  SRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLC---- 267
            + + E ++DLE E + +    ++   Q      E++      +  L S  ++Q L     
Sbjct: 1135 AALAEAQEDLESERVAR----TKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKRE 1190

Query: 268  --VNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQA 313
              V E  K+L     I++  V   R RH +  G   E+ ++ R+ K A
Sbjct: 1191 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGA 1238



 Score = 37.0 bits (84), Expect = 0.078
 Identities = 62/282 (21%), Positives = 104/282 (36%), Gaps = 70/282 (24%)

Query: 128  DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
            D +   +A+  Q+ + LQQ   R ++     R+ Q EEER  L    R   E   EAE  
Sbjct: 868  DEVLQARAQELQKVQELQQQSAR-EVGELQGRVAQLEEERARLAEQLRAEAELCAEAEET 926

Query: 188  E---QLESGEEELVLAEYES-------------DEEKKVASRVDEDEDDLEEEHITKIYY 231
                     E ELV++E E+              E+K++   + E E  LE E       
Sbjct: 927  RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE------ 980

Query: 232  CSRTHSQLAQFVHEVKKSPFGKDVRLVS-----LGSRQNLCVN-------------EDVK 273
             +R   QL +   E K   F +D+ L+      L   + L  +             E VK
Sbjct: 981  GARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVK 1040

Query: 274  SLGSVQL-----------------------------INDRCVDMQRSRHEKKKGAEEEKP 304
            SL  ++L                             ++    ++Q    E+++ AEE + 
Sbjct: 1041 SLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1100

Query: 305  KRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKE 346
            +  R+E++        E  G  R + L  +++ +  LA  +E
Sbjct: 1101 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQE 1142



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 78/334 (23%), Positives = 134/334 (40%), Gaps = 42/334 (12%)

Query: 62   LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGE----PAWVTQF 117
            L D ++  +EE    L  G+     E + +       E AA   R   E     A ++++
Sbjct: 1334 LHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEW 1393

Query: 118  VQKKEERDLVDRLKAEQARRKQRE-----ERLQQLQHRV-QLKYAAKRLRQEEEERENLL 171
             +++EE         E  RR  RE     +RL +    V +L+   +RL+QE ++    L
Sbjct: 1394 RRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL 1453

Query: 172  RLSREMLETGPEAER-LEQLESGEEELVL--------AEYESDEEKKVA---SRVDEDED 219
               R+++ T  + +R  +QL + E+  VL        AE E  E +  A   +R  E+E 
Sbjct: 1454 EQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQ 1513

Query: 220  DLEEE-------HITKIYYCSRTHSQLAQFVHEVKKS-----PFGKDVRLVSLGSRQNLC 267
            +  EE          ++     +   + + VHE++++         D+R         L 
Sbjct: 1514 EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELT 1573

Query: 268  VNEDVKSLGSVQLINDRCVDMQRSRHEKK-KGAEEEKPKRRRQ-EKQAACPFYNHEQMGL 325
              ED K      L  +  V   +++HE+  +G +E   +RRRQ  KQ        ++   
Sbjct: 1574 AAEDAK------LRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERK 1627

Query: 326  LRDEALAEVKDMEQLLALGKEARACPYYGSRLAI 359
             R  A+A  K +E  L   K   A    G   A+
Sbjct: 1628 QRTLAVAARKKLEGELEELKAQMASAGQGKEEAV 1661


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 60/228 (26%), Positives = 103/228 (45%), Gaps = 40/228 (17%)

Query: 121  KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAK------RLRQEEEERENLLRLS 174
            KE + L DRL    ++  + EE+++ L ++++LKY A       RLR+EE+ R+ L +L 
Sbjct: 1057 KERKLLEDRLAEFSSQAAEEEEKVKSL-NKLRLKYEATIADMEDRLRKEEKGRQELEKLK 1115

Query: 175  R-----------EMLETGPEAERLE-QLESGEEELVLAEYESDEE-----------KKVA 211
            R           +M+E    AE L  QL   EEEL  A   +++E           ++  
Sbjct: 1116 RRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQ 1175

Query: 212  SRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLC---- 267
            + + E ++DLE E + +    ++   Q      E++      +  L S  ++Q L     
Sbjct: 1176 AALAEAQEDLESERVAR----TKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKRE 1231

Query: 268  --VNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQA 313
              V E  K+L     I++  V   R RH +  G   E+ ++ R+ K A
Sbjct: 1232 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGA 1279



 Score = 37.0 bits (84), Expect = 0.078
 Identities = 62/282 (21%), Positives = 104/282 (36%), Gaps = 70/282 (24%)

Query: 128  DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
            D +   +A+  Q+ + LQQ   R ++     R+ Q EEER  L    R   E   EAE  
Sbjct: 909  DEVLQARAQELQKVQELQQQSAR-EVGELQGRVAQLEEERARLAEQLRAEAELCAEAEET 967

Query: 188  E---QLESGEEELVLAEYES-------------DEEKKVASRVDEDEDDLEEEHITKIYY 231
                     E ELV++E E+              E+K++   + E E  LE E       
Sbjct: 968  RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE------ 1021

Query: 232  CSRTHSQLAQFVHEVKKSPFGKDVRLVS-----LGSRQNLCVN-------------EDVK 273
             +R   QL +   E K   F +D+ L+      L   + L  +             E VK
Sbjct: 1022 GARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVK 1081

Query: 274  SLGSVQL-----------------------------INDRCVDMQRSRHEKKKGAEEEKP 304
            SL  ++L                             ++    ++Q    E+++ AEE + 
Sbjct: 1082 SLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA 1141

Query: 305  KRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKE 346
            +  R+E++        E  G  R + L  +++ +  LA  +E
Sbjct: 1142 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQE 1183



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 78/334 (23%), Positives = 134/334 (40%), Gaps = 42/334 (12%)

Query: 62   LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGE----PAWVTQF 117
            L D ++  +EE    L  G+     E + +       E AA   R   E     A ++++
Sbjct: 1375 LHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEW 1434

Query: 118  VQKKEERDLVDRLKAEQARRKQRE-----ERLQQLQHRV-QLKYAAKRLRQEEEERENLL 171
             +++EE         E  RR  RE     +RL +    V +L+   +RL+QE ++    L
Sbjct: 1435 RRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL 1494

Query: 172  RLSREMLETGPEAER-LEQLESGEEELVL--------AEYESDEEKKVA---SRVDEDED 219
               R+++ T  + +R  +QL + E+  VL        AE E  E +  A   +R  E+E 
Sbjct: 1495 EQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQ 1554

Query: 220  DLEEE-------HITKIYYCSRTHSQLAQFVHEVKKS-----PFGKDVRLVSLGSRQNLC 267
            +  EE          ++     +   + + VHE++++         D+R         L 
Sbjct: 1555 EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELT 1614

Query: 268  VNEDVKSLGSVQLINDRCVDMQRSRHEKK-KGAEEEKPKRRRQ-EKQAACPFYNHEQMGL 325
              ED K      L  +  V   +++HE+  +G +E   +RRRQ  KQ        ++   
Sbjct: 1615 AAEDAK------LRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERK 1668

Query: 326  LRDEALAEVKDMEQLLALGKEARACPYYGSRLAI 359
             R  A+A  K +E  L   K   A    G   A+
Sbjct: 1669 QRTLAVAARKKLEGELEELKAQMASAGQGKEEAV 1702


>gi|119120918 coiled-coil domain containing 64 [Homo sapiens]
          Length = 573

 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 56/246 (22%), Positives = 101/246 (41%), Gaps = 23/246 (9%)

Query: 71  EEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVDRL 130
           EEE  LL  G  P    +       S  EGA   P P+ +P  ++   QK+++  L  RL
Sbjct: 57  EEELALLAAGERPSDPGEHPQAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDLVLAARL 116

Query: 131 KAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERLEQL 190
                 R Q   R  +  H+ +L    + L QE+ E       +RE    G  +E    +
Sbjct: 117 GKALLERNQDMSRQYEQMHK-ELTDKLEHLEQEKHELRRRFE-NREGEWEGRVSELESDV 174

Query: 191 ESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSP 250
           +  ++EL   +    E  +  SR  ++  +  +  + ++   S    QL+  VH +++  
Sbjct: 175 KQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDF 234

Query: 251 FGKD-------VRLVSLGS--------------RQNLCVNEDVKSLGSVQLINDRCVDMQ 289
             K+       +RL SL +              R +  + E+    G+V+ + DR + ++
Sbjct: 235 REKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILE 294

Query: 290 RSRHEK 295
           R  H+K
Sbjct: 295 RQGHDK 300


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 50/199 (25%), Positives = 90/199 (45%), Gaps = 26/199 (13%)

Query: 116 QFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSR 175
           Q +++++E  L  RLK E+  R ++EER +Q           KR   EEE R+ LL+ S 
Sbjct: 588 QRLKREQEERLEQRLKREEVERLEQEERREQ---------RLKREEPEEERRQQLLK-SE 637

Query: 176 EMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDED--EDDLEEEHITKIYYCS 233
           E  E   +  R EQ E  E+ L   E E   E+++    +E+  E +L EE   +     
Sbjct: 638 EQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR--E 695

Query: 234 RTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRH 293
           R  S++ ++  +++     +  ++ S   +Q              Q       + +R R 
Sbjct: 696 RIKSRIPKWQWQLESEADARQSKVYSRPRKQ------------EGQRRRQEQEEKRRRRE 743

Query: 294 EKKKGAEEEKPKRRRQEKQ 312
            + +  EEE+  R++QE++
Sbjct: 744 SELQWQEEERAHRQQQEEE 762



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 50/226 (22%), Positives = 101/226 (44%), Gaps = 12/226 (5%)

Query: 120  KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLE 179
            +++ERD   R + +Q RR++RE +  Q + +++ +   ++ R+EE+ R+   +      E
Sbjct: 1685 RRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE 1744

Query: 180  TGPEAERLEQLESGEEELVLAEYESDEE--KKVASRVDEDEDDLEEEHITKIYYCSRTHS 237
               +    EQL    EE  L   E D +  ++   R + +E  L  +   + +   R   
Sbjct: 1745 RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKF---REEE 1801

Query: 238  QLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQ----LINDRCVDMQRSRH 293
            QL Q   E +  P  +D +       + L + E  + L   +       ++    ++SR 
Sbjct: 1802 QLRQEREEQQLRPQQRDGKY--RWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859

Query: 294  EKKKGAEEEKPKRRRQ-EKQAACPFYNHEQMGLLRDEALAEVKDME 338
            E+++  +EE+ KRR++ E++        +Q    R   + E+K  E
Sbjct: 1860 EEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQE 1905



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 53/197 (26%), Positives = 90/197 (45%), Gaps = 21/197 (10%)

Query: 120 KKEERDLVDRL-KAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
           K+E+ +  D+L K E+ RR+QR +R Q+ +   +LK       ++EE RE   RL RE  
Sbjct: 568 KREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQ--RLKRE-- 623

Query: 179 ETGPEAERLEQLESGEEELVLAEYE---SDEEKKVASRVDEDEDDLEEEHITKIYYCSRT 235
              PE ER +QL   EE+    + +     +E++      E+E++  E+ + + +   R 
Sbjct: 624 --EPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERR 681

Query: 236 HSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEK 295
             +LA+   E  +       R+ S   +    +  +  +  S      R  + QR R E 
Sbjct: 682 EQELAEEEQEQARE------RIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE- 734

Query: 296 KKGAEEEKPKRRRQEKQ 312
               +EEK +RR  E Q
Sbjct: 735 ----QEEKRRRRESELQ 747



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 47/198 (23%), Positives = 92/198 (46%), Gaps = 7/198 (3%)

Query: 116 QFVQKKEERDLVDR-LKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLS 174
           Q +++ +E +  +R LK E+  R++++ER +Q   R Q +   +RL+++EEE     RL 
Sbjct: 474 QQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR 533

Query: 175 REMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR 234
            E      + ER EQL   EEE  L E E  E++    + +  +  L+ E   +     R
Sbjct: 534 SEQQLRREQEERREQLLKREEEKRL-EQERREQRLKREQEERRDQLLKREEERRQQRLKR 592

Query: 235 THSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHE 294
              Q  +    +K+    +  RL     R+     E+ +     QL+     + +R +  
Sbjct: 593 --EQEERLEQRLKRE---EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQL 647

Query: 295 KKKGAEEEKPKRRRQEKQ 312
           +++  E  + + +R+E++
Sbjct: 648 RREQQERREQRLKREEEE 665



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 45/208 (21%), Positives = 90/208 (43%), Gaps = 19/208 (9%)

Query: 118 VQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREM 177
           V +KEE  L +     Q   ++ EE+L++L+ +       +R RQEEE+++  LR   + 
Sbjct: 252 VLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ-----ELRRERQEEEQQQQRLR-REQQ 305

Query: 178 LETGPEAERLEQLESGEEELVLAEYESD----------EEKKVASRVDEDEDDLEEEHIT 227
           L    E ER EQ E   E+    E + +          EE++      E E++  E+ + 
Sbjct: 306 LRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLR 365

Query: 228 KIYYCSRTHSQLAQFVHEVKKSPFGKDVRL---VSLGSRQNLCVNEDVKSLGSVQLINDR 284
           +     R   QL +     ++    ++ +L     L   Q L   + ++    ++     
Sbjct: 366 REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 425

Query: 285 CVDMQRSRHEKKKGAEEEKPKRRRQEKQ 312
             + +  RHE+K   E  + + +R++++
Sbjct: 426 RREQEEERHEQKHEQERREQRLKREQEE 453



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 67/237 (28%), Positives = 103/237 (43%), Gaps = 32/237 (13%)

Query: 115  TQFVQKKEERDLVDRLKAEQAR-RKQREERLQQLQ---------HRVQLKYAAKRLRQEE 164
            +Q   ++ ++DL   L  +Q R R+Q   R QQ            R + K A +R R+ +
Sbjct: 1256 SQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQ 1315

Query: 165  EERENLLRLSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEE 224
            EE++ LLR  RE      E +R    +  EEE +L E     E++   R + D    EEE
Sbjct: 1316 EEKQ-LLREEREEKRRRQETDR----KFREEEQLLQE----REEQPLRRQERDRKFREEE 1366

Query: 225  HITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDR 284
                     R   Q  +F+ E ++    +  R   L   Q L   E  + L   +    R
Sbjct: 1367 --------LRHQEQGRKFLEEEQRLRRQERERKF-LKEEQQLRCQEREQQLRQDRDRKFR 1417

Query: 285  CVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLL 341
              + Q SR E+ +   EE+ + RRQE++    F   EQ   LR E   + ++ EQLL
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQERER--KFLEEEQQ--LRQERHRKFREEEQLL 1470



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 70/308 (22%), Positives = 123/308 (39%), Gaps = 61/308 (19%)

Query: 66  EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
           ++ KREEE   LE      H+E+     L+   +  A     +  P W  Q   + + R 
Sbjct: 657 QRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQ 716

Query: 126 LV----DRLKAEQARRKQREERLQQLQHRVQL--KYAAKRLRQEEEERENL--------- 170
                  R +  Q RR+++EE+ ++ +  +Q   +  A R +QEEE+R +          
Sbjct: 717 SKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEK 776

Query: 171 -------------LRLSREMLETGPEAERLEQLESGEEE----------------LVLAE 201
                        LR  RE      E ++ EQ    EEE                  L E
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE 836

Query: 202 YESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLG 261
            E  + ++ A ++ E+ED L+E+   +     R   +    + E +K       R  +L 
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR------RRHTLY 890

Query: 262 SRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHE 321
           ++  L   E ++     QL+ +   ++QR   EK++  E+E+  R  ++ Q        E
Sbjct: 891 AKPAL--QEQLRK--EQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQ-------QE 939

Query: 322 QMGLLRDE 329
           +  LLR+E
Sbjct: 940 EEQLLREE 947



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 59/238 (24%), Positives = 100/238 (42%), Gaps = 16/238 (6%)

Query: 119 QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
           Q++E R+  +  + +Q RR+Q+EER +Q   R Q +   ++LR+E+EE     +L RE  
Sbjct: 310 QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ- 368

Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
               E ER EQ    E++L   +    E++    +    E  L  E   +     R   Q
Sbjct: 369 ----EEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 424

Query: 239 L----AQFVHEVKKSPFGKDVRL--VSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSR 292
           L     +  HE K     ++ RL       R  L   E+ +     +       D +  R
Sbjct: 425 LRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER 484

Query: 293 HEK--KKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEAR 348
            E+  K   EE + ++ R+E+Q         +  L R E   E + ++Q L   ++ R
Sbjct: 485 RERWLKLEEEERREQQERREQQLRREQEERREQRLKRQE---EEERLQQRLRSEQQLR 539



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 58/229 (25%), Positives = 108/229 (47%), Gaps = 37/229 (16%)

Query: 120 KKEERDLVDRLKAEQARRKQ---REERL--QQLQHRVQ--LKYAAKRLRQEEEERENLLR 172
           ++EER      + +Q RR+Q   RE+RL  Q+ + R+Q  L+   +  R++EE RE LL+
Sbjct: 492 EEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK 551

Query: 173 LSRE-MLETGPEAERLE-QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIY 230
              E  LE     +RL+ + E   ++L+  E E  +++    + +  E  L+ E + ++ 
Sbjct: 552 REEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLE 611

Query: 231 YCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQR 290
              R   +L +   E ++              RQ L  +E+ +     QL  ++    Q 
Sbjct: 612 QEERREQRLKREEPEEER--------------RQQLLKSEEQEERRQQQLRREQ----QE 653

Query: 291 SRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQ 339
            R ++ K  EEE+   +R +++       HE+    R++ LAE ++ EQ
Sbjct: 654 RREQRLKREEEEERLEQRLKRE-------HEEE--RREQELAE-EEQEQ 692



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 65/290 (22%), Positives = 121/290 (41%), Gaps = 21/290 (7%)

Query: 66  EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
           ++ KRE+E RL +     L  E+ E L      E       P  E        +++EER 
Sbjct: 588 QRLKREQEERLEQR----LKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER- 642

Query: 126 LVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAE 185
                + +Q RR+Q+E R Q+L+   + +   +RL++E EE      L+ E  E   E  
Sbjct: 643 -----RQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERI 697

Query: 186 RLE------QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQL 239
           +        QLES E +   ++  S   K+   R  +++++      +++ +     +  
Sbjct: 698 KSRIPKWQWQLES-EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHR 756

Query: 240 AQFVHEVKKS-PFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
            Q   E ++   +       S   RQ L     ++     QL  +     QR +    + 
Sbjct: 757 QQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE--RQQREQRFLPEE 814

Query: 299 AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEAR 348
            E+E+ +R+R+E++    F   E+  L R E   ++++ E  L   +E R
Sbjct: 815 EEKEQRRRQRREREKELQFLEEEEQ-LQRRERAQQLQEEEDGLQEDQERR 863



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 52/238 (21%), Positives = 98/238 (41%), Gaps = 46/238 (19%)

Query: 121  KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEE----ERENLLR---- 172
            ++ERD   RL+ ++ RR+++E +  + + +++ +   ++LRQE +    E E LL+    
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE 1633

Query: 173  -------LSREMLETGPEAERLEQLES---------GEEELVLAEYESD----------- 205
                     R+ LE  P+  R E+ +           EEE +L E E             
Sbjct: 1634 QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKF 1693

Query: 206  -EEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQ 264
             EE++   R + +   L+EE   +     R   +  Q   E ++    +  R   +   +
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEE 1753

Query: 265  NLCVNEDVKSL----------GSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQ 312
             L    + + L             QL  +R     RS+   +K  EEE+ ++ R+E+Q
Sbjct: 1754 QLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 67/273 (24%), Positives = 107/273 (39%), Gaps = 63/273 (23%)

Query: 121  KEERDLVDRLKAEQARRKQREERL----QQLQHRVQLKYAAKRLRQEEEERENLLRLSRE 176
            ++ERD   R + +Q RR++RE +     QQL+     K+  +    +E E + L R  R+
Sbjct: 1425 RQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERD 1484

Query: 177  --MLETGPEAERLE--------QLESGEEELVLAEYESD-------------------EE 207
               LE   +  R E        +L S E E    E E                     +E
Sbjct: 1485 RKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQE 1544

Query: 208  KKVASRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVK-------------KSPFGKD 254
            +    R D D    EEE + +     R   QL++   + K             +  F +D
Sbjct: 1545 RGQQRRQDRDRKFREEEQLRQ----EREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600

Query: 255  -VRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQA 313
              +L     +Q L    D K     QL+ +R  + Q  R E+ +   EE+P+ RRQE++ 
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQER-EEQQLHRQERDRKFLEEEPQLRRQEREQ 1659

Query: 314  ACPFYNHEQMGLLRDEALAEVKDMEQLLALGKE 346
                        LR +   + ++ EQLL  G+E
Sbjct: 1660 Q-----------LRHDRDRKFREEEQLLQEGEE 1681



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 57/218 (26%), Positives = 89/218 (40%), Gaps = 33/218 (15%)

Query: 63   RDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKE 122
            ++ E+K REEE    ET    L  ++     L           RP  E   +     +++
Sbjct: 1719 QELERKFREEEQLRQETEQEQLRRQERYRKILEEE------QLRPEREEQQL-----RRQ 1767

Query: 123  ERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-------RENLLRLSR 175
            ERD   + + E+  R++REE+  + Q   +     ++LRQE EE       R+   R   
Sbjct: 1768 ERDR--KFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEE 1825

Query: 176  EMLETGPEAERLEQLES----GEEELVLAEYESDEEKKV-----ASRVDEDEDDLEEEHI 226
            E L+   + +RL Q        EE+    E    EE+++       R  E E  L EEHI
Sbjct: 1826 EQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHI 1885

Query: 227  TKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQ 264
             +     + H Q    V E+K        RL+  G+ Q
Sbjct: 1886 RRQQKEEQRHRQ----VGEIKSQEGKGHGRLLEPGTHQ 1919



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 51/231 (22%), Positives = 103/231 (44%), Gaps = 24/231 (10%)

Query: 116  QFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSR 175
            Q +Q++EE      L+ E+  +++R+E+ +Q +   QL+   ++L +EE E+       R
Sbjct: 904  QLLQEEEEE-----LQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERER 958

Query: 176  EMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDL--EEEHITKIYYCS 233
            +  +     ++ EQL  GEE       E +++ +    + ++E+ L  EE    +     
Sbjct: 959  QYRKDKKLQQKEEQL-LGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE 1017

Query: 234  RTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIND-----RCVDM 288
            R + +  +   E ++    ++     L  R+     E+       QL+ +     R  ++
Sbjct: 1018 RQYRKKDELQQE-EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076

Query: 289  QRS-------RHEKKKGAEEEKPKRRRQEKQAAC---PFYNHEQMGLLRDE 329
            +R        + E+++   EE  KRRRQE++  C        E+  LLR+E
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREE 1127



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 46/204 (22%), Positives = 94/204 (46%), Gaps = 11/204 (5%)

Query: 113  WVTQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLR 172
            W  Q+ +K E +      + EQ  R++RE+R  +LQ R +     + L+QEEE+     R
Sbjct: 1016 WERQYRKKDELQQ-----EEEQLLREEREKR--RLQERERQYREEEELQQEEEQLLGEER 1068

Query: 173  LSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDED-DLEEEHITKIYY 231
             +R   E   +  + E+L+  EE+L+  E E    ++   +  E+E+   EEE + +   
Sbjct: 1069 ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128

Query: 232  CSRTHSQL-AQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCV--DM 288
              R   +L  Q+  E +     + +       R+   +    +    +Q   ++ +  + 
Sbjct: 1129 EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQ 1188

Query: 289  QRSRHEKKKGAEEEKPKRRRQEKQ 312
            ++ R E+++   EE+  +R++ KQ
Sbjct: 1189 EKRRQERERQYREEEELQRQKRKQ 1212



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 54/221 (24%), Positives = 97/221 (43%), Gaps = 26/221 (11%)

Query: 116  QFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSR 175
            Q +Q++EE+ L    + ++  RK REE L+  +   +     +RLR++E ER+ L    +
Sbjct: 1343 QLLQEREEQPL----RRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398

Query: 176  EMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRT 235
               +     ER +QL    +       +  EE++  SR + D    EEE   +     R 
Sbjct: 1399 LRCQ-----EREQQLRQDRDR------KFREEEQQLSRQERDRKFREEEQQVRRQERERK 1447

Query: 236  HSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNE-DVKSLGSVQLINDRCVDMQ----- 289
              +  Q + + +   F ++ +L+     Q L   E D K L   Q +  +  D +     
Sbjct: 1448 FLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQE 1507

Query: 290  -RSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDE 329
             RS+  ++K  EEE+   R+Q ++     +  E+  L R E
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRK----FLQEEQQLRRQE 1544



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 39/197 (19%), Positives = 89/197 (45%), Gaps = 6/197 (3%)

Query: 116 QFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSR 175
           Q ++++++     +L+ EQ  R+++EE   + +H  + +   +RL++E+EER + L+   
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR--EQRLKREQEERRDWLKREE 462

Query: 176 EMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRT 235
           E  E   +  R +QL+  +EE     +   EE++   + +  E  L  E   +     + 
Sbjct: 463 E-TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKR 521

Query: 236 HSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEK 295
             +  +    ++     + +R      R+ L   E+ K L   +       + +  R + 
Sbjct: 522 QEEEERLQQRLRSE---QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL 578

Query: 296 KKGAEEEKPKRRRQEKQ 312
            K  EE + +R ++E++
Sbjct: 579 LKREEERRQQRLKREQE 595



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 49/194 (25%), Positives = 81/194 (41%), Gaps = 35/194 (18%)

Query: 119 QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
           Q++  R+   R K E+ RR+Q+EER +Q + R           Q+EE RE  LR  RE  
Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERR----------EQQEERREQQLR--REQE 344

Query: 179 ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
           E   +  R EQ E   E+ +  E E +  ++   R    E  L  E   +     R   Q
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRR----EQQLRREQQLRREQQLRREQQ 400

Query: 239 LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
           L                R   L   Q L   + ++     QL  ++  +    +HE+++ 
Sbjct: 401 LR---------------REQQLRREQQLRREQQLRR--EQQLRREQEEERHEQKHEQER- 442

Query: 299 AEEEKPKRRRQEKQ 312
             E++ KR ++E++
Sbjct: 443 -REQRLKREQEERR 455



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 45/214 (21%), Positives = 97/214 (45%), Gaps = 28/214 (13%)

Query: 116  QFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSR 175
            Q+ +++E +   ++L  E+  +++R+E  +Q +   +L+   ++L +EE+E+    R  +
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQ 1198

Query: 176  EMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRT 235
               E   + ++ +Q    E++    +++ + EK+ A R +            K+Y   R 
Sbjct: 1199 YREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDN------------KVYCKGRE 1246

Query: 236  HSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEK 295
            + Q  Q           +D +L    S+Q      D++ L   Q   DR  + +R +   
Sbjct: 1247 NEQFRQL----------EDSQLRDRQSQQ------DLQHLLGEQQERDREQERRRWQQRD 1290

Query: 296  KKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDE 329
            +   EEE+ +R  Q++       + E+  LLR+E
Sbjct: 1291 RHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE 1324



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 58/265 (21%), Positives = 109/265 (41%), Gaps = 47/265 (17%)

Query: 63   RDFEQKKREEEARLLETGTGPLHDEKDESLC----LSSSCEGAAGT-PRPAGEPAWVTQF 117
            R+ EQ ++EEE  L E        E++        L    E   G  P          ++
Sbjct: 931  REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990

Query: 118  VQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREM 177
             +++E +   ++L  E+  +++R+E  +Q + + +L+   ++L +EE E+  L    R+ 
Sbjct: 991  REEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY 1050

Query: 178  LETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHS 237
                 E E L+Q    EEE +L E      ++   R    E++L++E             
Sbjct: 1051 ----REEEELQQ----EEEQLLGEERETRRRQELERQYRKEEELQQE-----------EE 1091

Query: 238  QLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIND-----RCVDMQRSR 292
            QL +   E ++              R+  C  E+       QL+ +     R  +++R  
Sbjct: 1092 QLLREEPEKRRRQ-----------ERERQCREEEELQQEEEQLLREEREKRRRQELERQY 1140

Query: 293  HEKKKGAEEEK-------PKRRRQE 310
             E+++  +EE+        KRRRQE
Sbjct: 1141 REEEEVQQEEEQLLREEPEKRRRQE 1165



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 52/227 (22%), Positives = 102/227 (44%), Gaps = 17/227 (7%)

Query: 131 KAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERLEQL 190
           + +Q RR+Q+  R QQL+   QL+   ++LR+E+EE  +  +  +E  E   + E+ E+ 
Sbjct: 397 REQQLRREQQLRREQQLRREQQLR-REQQLRREQEEERHEQKHEQERREQRLKREQEERR 455

Query: 191 ESGEEELVLAEYESDEEKKVASRVDEDED-----DLEEEHITKIYYCSRTHSQLAQFVHE 245
           +  + E     +E +  K+   R  E+E       LEEE   +     R   QL +   E
Sbjct: 456 DWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEE--RREQQERREQQLRREQEE 513

Query: 246 VKKSPFGK---DVRLVS-LGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEE 301
            ++    +   + RL   L S Q L   ++ +    ++   ++ ++ +R     K+  EE
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE 573

Query: 302 EKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEAR 348
            + +  ++E++        EQ     +E L +    E++  L +E R
Sbjct: 574 RRDQLLKREEERRQQRLKREQ-----EERLEQRLKREEVERLEQEER 615



 Score = 38.9 bits (89), Expect = 0.021
 Identities = 64/322 (19%), Positives = 137/322 (42%), Gaps = 29/322 (9%)

Query: 25  DFMAELYRVLEAGKIGIFESPTGTGKSLSLIC-GALSWLRDFEQKKREEEARLLETGTGP 83
           +F+  +++V +A    + ++ TG  +     C G  S L+D   +++EE+ R  E     
Sbjct: 73  EFLLFIFKVAQACYYALGQA-TGLDEEKRARCDGKESLLQD---RRQEEDQRRFEPRDRQ 128

Query: 84  LHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVDRLKAEQARRKQREER 143
           L +E  +        +      R   E    ++  ++ E+RD   R +    +R++ +ER
Sbjct: 129 LEEEPGQR-----RRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQER 183

Query: 144 LQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEA-ERLEQLESGEEELVLAEY 202
            ++     QL+       +E  + E L R  RE+LE   +  E  +Q     ++ V  E 
Sbjct: 184 EERRAEEEQLQSCKGHETEEFPDEEQLRR--RELLELRRKGREEKQQQRRERQDRVFQEE 241

Query: 203 ESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLAQFV-HEVKKSPFGKDVRLVSLG 261
           E  E +K  + + ++E+ L+EE   +         QL +    E+++    ++ +   L 
Sbjct: 242 EEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLR 301

Query: 262 SRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKR----RRQEKQAACPF 317
             Q L   ++           +   + Q  R E+++  E+++ +R    RR++++     
Sbjct: 302 REQQLRRKQE-----------EERREQQEERREQQERREQQEERREQQLRREQEERREQQ 350

Query: 318 YNHEQMGLLRDEALAEVKDMEQ 339
              EQ    R++ L   ++ E+
Sbjct: 351 LRREQEEERREQQLRREQEEER 372



 Score = 38.5 bits (88), Expect = 0.027
 Identities = 29/107 (27%), Positives = 53/107 (49%), Gaps = 2/107 (1%)

Query: 120 KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLE 179
           +++ RD   R + E+ R+++R     +   + QL+   + L++EEEE +   R  R   E
Sbjct: 866 QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQE 925

Query: 180 TGPEAERLEQLESGEEELVLAEYES--DEEKKVASRVDEDEDDLEEE 224
              +    EQL+  EE+L+  E E    +E++   R D+     EE+
Sbjct: 926 QERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQ 972



 Score = 38.1 bits (87), Expect = 0.035
 Identities = 54/232 (23%), Positives = 103/232 (44%), Gaps = 34/232 (14%)

Query: 119  QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLR-QEEEER--ENLLRLSR 175
            Q++++RD   R + EQ R+++ E++L + +   + +   +++R QE+E +  E+  +L R
Sbjct: 1548 QRRQDRDRKFR-EEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRR 1606

Query: 176  EMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRT 235
            +  +     ER  +    E+ L       + E++   R + D   LEEE         R 
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLL------QEREEQQLHRQERDRKFLEEEPQL------RR 1654

Query: 236  HSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEK 295
              +  Q  H+ +   F ++ +L+  G  Q L   E  +          R  + Q  R E+
Sbjct: 1655 QEREQQLRHD-RDRKFREEEQLLQEGEEQQLRRQERDRKF--------REEEQQLRRQER 1705

Query: 296  KKGAEEEKPKRRRQEKQAACPFYNHEQM-------GLLRDEALAEVKDMEQL 340
            ++   +E+ + RRQE +    F   EQ+        L R E   ++ + EQL
Sbjct: 1706 ERKFLQEEQQLRRQELER--KFREEEQLRQETEQEQLRRQERYRKILEEEQL 1755


>gi|22758136 MAP7 domain containing 2 [Homo sapiens]
          Length = 732

 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 41/187 (21%)

Query: 66  EQKKREEEARLLETGTGPL------------HDEKDESLCLSSSCEGAAGTPRP------ 107
           E+  +E E  L +   GP             H  +  +       E +A   +P      
Sbjct: 337 EKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTD 396

Query: 108 AGEPAWVT------------QFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKY 155
           AGE A +             Q  Q++ E++  DRL+ E+ +RK  EERL+ L+   + K 
Sbjct: 397 AGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLR-LEEEAR-KQ 454

Query: 156 AAKRLRQEEEERENLLRLSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVD 215
             +R RQEEE+++   +   E  + G EA+R       EEEL+L E + ++EK+  + ++
Sbjct: 455 EEERKRQEEEKKK---QEGEEKRKAGEEAKR-----KAEEELLLKE-KQEQEKQEKAMIE 505

Query: 216 EDEDDLE 222
           + ++  E
Sbjct: 506 KQKEAAE 512



 Score = 33.5 bits (75), Expect = 0.86
 Identities = 23/83 (27%), Positives = 39/83 (46%), Gaps = 6/83 (7%)

Query: 119 QKKEERDLVDRLKAEQARRKQREERL------QQLQHRVQLKYAAKRLRQEEEERENLLR 172
           +KK++     R   E+A+RK  EE L      Q+ Q +  ++   +    +  E    +R
Sbjct: 464 EKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMR 523

Query: 173 LSREMLETGPEAERLEQLESGEE 195
           L RE +    E ERLE+ +  +E
Sbjct: 524 LEREQIMLQIEQERLERKKRIDE 546



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 30/124 (24%), Positives = 53/124 (42%), Gaps = 11/124 (8%)

Query: 79  TGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVDRLKAEQARRK 138
           TG+ P    +  SL    +  GA  T +P   P  +  F++  E + L       + RR+
Sbjct: 10  TGSRPEGTARGTSLPGKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLA------KERRE 63

Query: 139 QREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLS-----REMLETGPEAERLEQLESG 193
           +RE+ L   + ++  K    RL+ E++  E   +L       +      E +R ++L   
Sbjct: 64  EREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREE 123

Query: 194 EEEL 197
           EE L
Sbjct: 124 EERL 127



 Score = 31.6 bits (70), Expect = 3.3
 Identities = 29/103 (28%), Positives = 52/103 (50%), Gaps = 13/103 (12%)

Query: 119 QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEEREN----LLRLS 174
           +K+EE    +R + E+ ++KQ  E  ++     + K   + L +E++E+E     ++   
Sbjct: 452 RKQEE----ERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQ 507

Query: 175 REMLETGPEAERLEQLESGEEELVL-AEYESDEEKKVASRVDE 216
           +E  ET    E  EQ+    E+++L  E E  E KK   R+DE
Sbjct: 508 KEAAET-KAREVAEQMRLEREQIMLQIEQERLERKK---RIDE 546



 Score = 31.2 bits (69), Expect = 4.3
 Identities = 24/77 (31%), Positives = 40/77 (51%), Gaps = 10/77 (12%)

Query: 116 QFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEER-ENLLRLS 174
           Q ++K++   L    + E+  RK  E+R ++ Q R  ++   K+  +EEEER E ++R S
Sbjct: 75  QILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRS 134

Query: 175 REMLETGPEAERLEQLE 191
                     ER +QLE
Sbjct: 135 ---------LERTQQLE 142


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 43/146 (29%), Positives = 73/146 (50%), Gaps = 9/146 (6%)

Query: 67  QKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDL 126
           ++K+EEEAR L        + + + L      E      + A       Q  Q++ E++ 
Sbjct: 638 RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 697

Query: 127 VDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEE--ERENLLRLSREMLETGPE 183
            ++ + EQ RR+Q R E+ +QL  + + +   +RL+ E E  ERE  LRL +E L+    
Sbjct: 698 REQERREQERREQERREQERQLAEQ-ERRREQERLQAERELQEREKALRLQKEQLQ---- 752

Query: 184 AERLEQLESGEEELVLAEYESDEEKK 209
              LE+ +  EE+  LAE +  EE++
Sbjct: 753 -RELEEKKKKEEQQRLAERQLQEEQE 777



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 52/199 (26%), Positives = 90/199 (45%), Gaps = 32/199 (16%)

Query: 118 VQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLR---QEEEERENLLRLS 174
           + +K E+   +RL  E+A++K   +++++++ R + +  A+RLR   QEEEER +     
Sbjct: 606 IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH----- 660

Query: 175 REMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR 234
           +E+L+   E E+ E+L    E   LAE    E ++   R  E  +    E   +      
Sbjct: 661 QELLQKKKEEEQ-ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERR-----E 714

Query: 235 THSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHE 294
              QLA+     ++           L + + L   E    L   QL        QR   E
Sbjct: 715 QERQLAEQERRREQE---------RLQAERELQEREKALRLQKEQL--------QRELEE 757

Query: 295 KKKGAEEEK-PKRRRQEKQ 312
           KKK  E+++  +R+ QE+Q
Sbjct: 758 KKKKEEQQRLAERQLQEEQ 776



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 56/236 (23%), Positives = 107/236 (45%), Gaps = 38/236 (16%)

Query: 118 VQKKEERDLVDRLKAEQARRKQREE-RLQQLQHRVQLKYAAKRLRQEEEERENLLRLSRE 176
           +++KEE + + R K E+ +R++ EE +L++ +   ++  A +R+ Q +EE++  +     
Sbjct: 545 LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFA 604

Query: 177 MLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDE-DDLEEEHITKIYYC--- 232
            ++        E+ E  +EE  LAE E  ++K  A +++E E    +EE   ++ +    
Sbjct: 605 QID--------EKTEKAKEER-LAE-EKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 654

Query: 233 --SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQR 290
              R H +L Q   E ++    K      L  ++     E                  Q 
Sbjct: 655 EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE------------------QE 696

Query: 291 SRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKE 346
            R ++++  E  + +RR QE+Q A      EQ  L   +A  E+++ E+ L L KE
Sbjct: 697 RREQERREQERREQERREQERQLAEQERRREQERL---QAERELQEREKALRLQKE 749



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 40/165 (24%), Positives = 75/165 (45%), Gaps = 6/165 (3%)

Query: 63  RDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKE 122
           +  EQK  + + +  +     L +EK +    +   E      +   E   +    Q++E
Sbjct: 597 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 656

Query: 123 ERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLS--REMLET 180
           ER   + L   Q ++++ +ERL++     +L    ++ R+E+E RE   R    RE    
Sbjct: 657 ERRHQELL---QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERR 713

Query: 181 GPEAERLEQLESGEEELVLAEYESDE-EKKVASRVDEDEDDLEEE 224
             E +  EQ    E+E + AE E  E EK +  + ++ + +LEE+
Sbjct: 714 EQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK 758



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 31/121 (25%), Positives = 60/121 (49%), Gaps = 9/121 (7%)

Query: 116 QFVQKKEERDLVDRLK--------AEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEER 167
           + +QKK+E +  +RL+        AEQ  +++RE+  ++ + R Q +   +R  QE +  
Sbjct: 662 ELLQKKKEEEQ-ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 720

Query: 168 ENLLRLSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
           E   R  +E L+   E +  E+    ++E +  E E  ++K+   R+ E +   E+E   
Sbjct: 721 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 780

Query: 228 K 228
           K
Sbjct: 781 K 781


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 43/146 (29%), Positives = 73/146 (50%), Gaps = 9/146 (6%)

Query: 67  QKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDL 126
           ++K+EEEAR L        + + + L      E      + A       Q  Q++ E++ 
Sbjct: 634 RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 693

Query: 127 VDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEE--ERENLLRLSREMLETGPE 183
            ++ + EQ RR+Q R E+ +QL  + + +   +RL+ E E  ERE  LRL +E L+    
Sbjct: 694 REQERREQERREQERREQERQLAEQ-ERRREQERLQAERELQEREKALRLQKEQLQ---- 748

Query: 184 AERLEQLESGEEELVLAEYESDEEKK 209
              LE+ +  EE+  LAE +  EE++
Sbjct: 749 -RELEEKKKKEEQQRLAERQLQEEQE 773



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 52/199 (26%), Positives = 90/199 (45%), Gaps = 32/199 (16%)

Query: 118 VQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLR---QEEEERENLLRLS 174
           + +K E+   +RL  E+A++K   +++++++ R + +  A+RLR   QEEEER +     
Sbjct: 602 IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH----- 656

Query: 175 REMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR 234
           +E+L+   E E+ E+L    E   LAE    E ++   R  E  +    E   +      
Sbjct: 657 QELLQKKKEEEQ-ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERR-----E 710

Query: 235 THSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHE 294
              QLA+     ++           L + + L   E    L   QL        QR   E
Sbjct: 711 QERQLAEQERRREQE---------RLQAERELQEREKALRLQKEQL--------QRELEE 753

Query: 295 KKKGAEEEK-PKRRRQEKQ 312
           KKK  E+++  +R+ QE+Q
Sbjct: 754 KKKKEEQQRLAERQLQEEQ 772



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 62/239 (25%), Positives = 109/239 (45%), Gaps = 36/239 (15%)

Query: 120 KKEERDLVDRLK----AEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSR 175
           K++ER  ++ L+    AEQ RR++ EE  ++    V+LK   +RLR+  + RE + ++  
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLK-REERLRKVLQARERVEQMKE 589

Query: 176 EMLETGPE--AERLEQLESGEEELVLAEYESDEEKKVASRVDEDE-DDLEEEHITKIYYC 232
           E  +   +  A+  E+ E  +EE  LAE E  ++K  A +++E E    +EE   ++ + 
Sbjct: 590 EKKKQIEQKFAQIDEKTEKAKEER-LAE-EKAKKKAAAKKMEEVEARRKQEEEARRLRWL 647

Query: 233 -----SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVD 287
                 R H +L Q   E ++    K      L  ++     E                 
Sbjct: 648 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE----------------- 690

Query: 288 MQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKE 346
            Q  R ++++  E  + +RR QE+Q A      EQ  L   +A  E+++ E+ L L KE
Sbjct: 691 -QERREQERREQERREQERREQERQLAEQERRREQERL---QAERELQEREKALRLQKE 745



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 40/165 (24%), Positives = 75/165 (45%), Gaps = 6/165 (3%)

Query: 63  RDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKE 122
           +  EQK  + + +  +     L +EK +    +   E      +   E   +    Q++E
Sbjct: 593 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 652

Query: 123 ERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLS--REMLET 180
           ER   + L   Q ++++ +ERL++     +L    ++ R+E+E RE   R    RE    
Sbjct: 653 ERRHQELL---QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERR 709

Query: 181 GPEAERLEQLESGEEELVLAEYESDE-EKKVASRVDEDEDDLEEE 224
             E +  EQ    E+E + AE E  E EK +  + ++ + +LEE+
Sbjct: 710 EQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK 754



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 31/121 (25%), Positives = 60/121 (49%), Gaps = 9/121 (7%)

Query: 116 QFVQKKEERDLVDRLK--------AEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEER 167
           + +QKK+E +  +RL+        AEQ  +++RE+  ++ + R Q +   +R  QE +  
Sbjct: 658 ELLQKKKEEEQ-ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 716

Query: 168 ENLLRLSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
           E   R  +E L+   E +  E+    ++E +  E E  ++K+   R+ E +   E+E   
Sbjct: 717 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 776

Query: 228 K 228
           K
Sbjct: 777 K 777


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 72/284 (25%), Positives = 120/284 (42%), Gaps = 35/284 (12%)

Query: 71   EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
            EEE R+    LE         + E   L +  E A    R A E A  + + VQ + +R 
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510

Query: 125  -----DLVDRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
                 +L  R+KAE    ++++  LQ L+  R+Q + A +RLRQ E ER   ++++ E  
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570

Query: 179  ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
            +   EAE    L+S             +    A +  + E  L+EEH+  +        +
Sbjct: 1571 QRSAEAE----LQS-------------KRASFAEKTAQLERSLQEEHVA-VAQLREEAER 1612

Query: 239  LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
             AQ   E +++    +  L     R  L  NE ++     + +  +    Q    ++K+ 
Sbjct: 1613 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668

Query: 299  AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
            AE E  +R + E+QA       EQ  L +   LAE    ++L A
Sbjct: 1669 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1711



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 80/376 (21%), Positives = 154/376 (40%), Gaps = 40/376 (10%)

Query: 68   KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
            + ++   R L+     +    +E+  LS + + AA   + A E     + + +K  ++ +
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316

Query: 128  DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
              ++ E  R K   E LQQ +   Q +  A+RL++++E+    L    +  +   EAER 
Sbjct: 2317 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373

Query: 188  EQLESGEE---------ELVLAEYESDEE----KKVASRVDEDEDDLEEEHITKIYYCSR 234
             QLE   E         E+  A+  ++E+    +K A  + E     E     K+     
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433

Query: 235  THSQLAQFVH------------EVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIN 282
               Q  Q  H            E +K    ++ +L+ L S +   V ++ + L   Q + 
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQ 2492

Query: 283  DRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDMEQL 340
               +  + S  ++++  E+EK K  +  Q++ A       EQ    R +   E ++ ++L
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQRL 2548

Query: 341  LALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLI 399
            +A  +EAR   +     +     +L  L  Q             RL++Q+ +++E H   
Sbjct: 2549 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR-- 2606

Query: 400  DTITGMHSVEVSGSQL 415
                  HS EV+ SQ+
Sbjct: 2607 --AALAHSEEVTASQV 2620



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 32/278 (11%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
            EQ++ EE  RL E        EK   L   +  +  A   R A E       +Q++ + +
Sbjct: 1352 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1400

Query: 126  LVDRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
            +V R +A    Q +++  +E LQQL+   + +  AK          RLR EEE R   L+
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460

Query: 173  LSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYC 232
            L     + G     L+ L +  EE    + ++ EE +   R  +DE   + +   ++   
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--AEVELA 1518

Query: 233  SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSR 292
            SR  ++      + +     +++RL +  + + L    +V+    VQ+  +       + 
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAE 1577

Query: 293  HEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEA 330
             + K+ +  EK  +  +  Q       H  +  LR+EA
Sbjct: 1578 LQSKRASFAEKTAQLERSLQE-----EHVAVAQLREEA 1610



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 89/382 (23%), Positives = 152/382 (39%), Gaps = 64/382 (16%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
            E ++ E++ +LLE     L  E   +       E      R   E    ++   ++E R 
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780

Query: 126  LVD----RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLSRE 176
              +    RL+AE  R ++  E   +L+    L   AKR RQ  EE     R    R+  E
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837

Query: 177  MLETGPEAERLE--------QLESGEEELV-LAEYESDEEKKVASRVDEDEDDLEEEHIT 227
             L    EA RL+        + E+  E L  LAE E+ + +++  +  + + D+EE    
Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE---- 1893

Query: 228  KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSL---------GSV 278
                      +LAQ + +   S   +   LV    RQ   V E++ +L         G  
Sbjct: 1894 ----------RLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942

Query: 279  QL------INDRCVDMQRSRHE-------KKKGAEEEKPKRRRQEKQAACPFYNHEQMGL 325
            +L      I     D  RS+ +       +++ A EE+ +RR  E++        E+   
Sbjct: 1943 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2002

Query: 326  LRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATR-QAAGIR 384
             R  AL EV   E+L A  +EAR       + +    QL     Q  L A  +  A  ++
Sbjct: 2003 QRKAALEEV---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059

Query: 385  LQDQVV--IIDEAHNLIDTITG 404
             ++Q +   + +  +++D + G
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRG 2081



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 46/211 (21%), Positives = 85/211 (40%), Gaps = 19/211 (9%)

Query: 120  KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE--------RENLL 171
            K EE+ +  R  AEQ   KQR+      Q R+  +    RLR E E+         E L 
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737

Query: 172  RLSREMLETGPEAERLE----QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
            RL RE      + + LE    ++ +  E L+ ++  ++EE +  S   +   + E     
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797

Query: 228  KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC-- 285
            ++   +   ++L     E K+     +       +     + E + ++G    +      
Sbjct: 1798 EL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1854

Query: 286  --VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
               + +      ++ AE+E  +RRR E+QAA
Sbjct: 1855 ALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1885



 Score = 37.4 bits (85), Expect = 0.060
 Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 25/194 (12%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
            E++K ++EA+LL+  +  +   + E L   +     +             ++ Q   K E
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2517

Query: 123  ERDLVDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
            +    +  KA+Q R +Q R+++ Q  Q R +L  + +  R+ + E E  +R  +E     
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2571

Query: 182  PEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR-THSQLA 240
             E ++LEQ    +EEL+  E +         R+ E    LEE+H   + +    T SQ+A
Sbjct: 2572 -ELQQLEQQRRQQEELLAEENQ---------RLREQLQLLEEQHRAALAHSEEVTASQVA 2621

Query: 241  QFVHEVKKSPFGKD 254
                  K  P G+D
Sbjct: 2622 ----ATKTLPNGRD 2631



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 62/292 (21%), Positives = 108/292 (36%), Gaps = 39/292 (13%)

Query: 62   LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSS------SCEGAAGTPRPAG-EPAWV 114
            ++D  Q+KR+ E  L           +++   L +        E A    R A  E A  
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562

Query: 115  TQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKY-AAKRLRQEEEER-ENLLR 172
             Q   +  +R     L   Q++R    E+  QL+  +Q ++ A  +LR+E E R +    
Sbjct: 1563 VQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE 1619

Query: 173  LSREMLETGPEAERLE-----------QLESGEEELVLAEYESDEEKKVASRVDEDEDDL 221
              R   E   E ER +           Q E   ++  LA+ E++++K+ A R        
Sbjct: 1620 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679

Query: 222  EEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
            EE+ + +     +   +  Q      +     +  L+ L +       E  +     QL+
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-------ETEQGEQQRQLL 1732

Query: 282  NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAE 333
             +    +QR         E     ++RQE +A       E   LL  +A AE
Sbjct: 1733 EEELARLQR---------EAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 75/391 (19%), Positives = 141/391 (36%), Gaps = 48/391 (12%)

Query: 59   LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
            L+ LR     + E +  L+E         ++E L L +S E AA     AG+        
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1942

Query: 119  QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
                       L+ E  R +   E   + + + +L+ A +R    EEER       R   
Sbjct: 1943 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1992

Query: 179  ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
                E E   Q ++  EE+   + + +E +++  R +++               S    Q
Sbjct: 1993 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE---------------SARQLQ 2037

Query: 239  LAQFVHEVKKSPFGKDVRLVSLGSRQNL--CVNEDVKSLGSVQLINDRCVDMQRSRHEKK 296
            LAQ   + +     K          Q L   + ++   L  ++   +          E +
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097

Query: 297  KGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSR 356
              AE E  + RRQ ++A     + E+    R +A A  + + +        RA     + 
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157

Query: 357  LAIPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTITGMHSVEVS 411
                AA   +  ++       RQ A +      L+ Q+   D   NL+D    +  ++  
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAE 2215

Query: 412  GSQLCQAHSQLLQYVERYGKRLKAKNLMYLK 442
             ++  +  SQ+ +  E +  R++ + L  LK
Sbjct: 2216 ATEAARQRSQVEE--ELFSVRVQMEELSKLK 2244



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 24/97 (24%), Positives = 45/97 (46%), Gaps = 1/97 (1%)

Query: 121  KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
            +EE  L ++ +AE+  R    E   + Q ++   +A  + + E E +E   R+  E++  
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404

Query: 181  GPEA-ERLEQLESGEEELVLAEYESDEEKKVASRVDE 216
               A +  +Q  S +EEL      S+ E +  +R  E
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1441


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 72/284 (25%), Positives = 120/284 (42%), Gaps = 35/284 (12%)

Query: 71   EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
            EEE R+    LE         + E   L +  E A    R A E A  + + VQ + +R 
Sbjct: 1455 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1514

Query: 125  -----DLVDRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
                 +L  R+KAE    ++++  LQ L+  R+Q + A +RLRQ E ER   ++++ E  
Sbjct: 1515 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1574

Query: 179  ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
            +   EAE    L+S             +    A +  + E  L+EEH+  +        +
Sbjct: 1575 QRSAEAE----LQS-------------KRASFAEKTAQLERSLQEEHVA-VAQLREEAER 1616

Query: 239  LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
             AQ   E +++    +  L     R  L  NE ++     + +  +    Q    ++K+ 
Sbjct: 1617 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1672

Query: 299  AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
            AE E  +R + E+QA       EQ  L +   LAE    ++L A
Sbjct: 1673 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1715



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 80/376 (21%), Positives = 154/376 (40%), Gaps = 40/376 (10%)

Query: 68   KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
            + ++   R L+     +    +E+  LS + + AA   + A E     + + +K  ++ +
Sbjct: 2261 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2320

Query: 128  DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
              ++ E  R K   E LQQ +   Q +  A+RL++++E+    L    +  +   EAER 
Sbjct: 2321 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377

Query: 188  EQLESGEE---------ELVLAEYESDEE----KKVASRVDEDEDDLEEEHITKIYYCSR 234
             QLE   E         E+  A+  ++E+    +K A  + E     E     K+     
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2437

Query: 235  THSQLAQFVH------------EVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIN 282
               Q  Q  H            E +K    ++ +L+ L S +   V ++ + L   Q + 
Sbjct: 2438 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQ 2496

Query: 283  DRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDMEQL 340
               +  + S  ++++  E+EK K  +  Q++ A       EQ    R +   E ++ ++L
Sbjct: 2497 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQRL 2552

Query: 341  LALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLI 399
            +A  +EAR   +     +     +L  L  Q             RL++Q+ +++E H   
Sbjct: 2553 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR-- 2610

Query: 400  DTITGMHSVEVSGSQL 415
                  HS EV+ SQ+
Sbjct: 2611 --AALAHSEEVTASQV 2624



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 32/278 (11%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
            EQ++ EE  RL E        EK   L   +  +  A   R A E       +Q++ + +
Sbjct: 1356 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1404

Query: 126  LVDRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
            +V R +A    Q +++  +E LQQL+   + +  AK          RLR EEE R   L+
Sbjct: 1405 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1464

Query: 173  LSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYC 232
            L     + G     L+ L +  EE    + ++ EE +   R  +DE   + +   ++   
Sbjct: 1465 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--AEVELA 1522

Query: 233  SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSR 292
            SR  ++      + +     +++RL +  + + L    +V+    VQ+  +       + 
Sbjct: 1523 SRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAE 1581

Query: 293  HEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEA 330
             + K+ +  EK  +  +  Q       H  +  LR+EA
Sbjct: 1582 LQSKRASFAEKTAQLERSLQE-----EHVAVAQLREEA 1614



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 89/382 (23%), Positives = 152/382 (39%), Gaps = 64/382 (16%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
            E ++ E++ +LLE     L  E   +       E      R   E    ++   ++E R 
Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1784

Query: 126  LVD----RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLSRE 176
              +    RL+AE  R ++  E   +L+    L   AKR RQ  EE     R    R+  E
Sbjct: 1785 TSEKSKQRLEAEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAE 1841

Query: 177  MLETGPEAERLE--------QLESGEEELV-LAEYESDEEKKVASRVDEDEDDLEEEHIT 227
             L    EA RL+        + E+  E L  LAE E+ + +++  +  + + D+EE    
Sbjct: 1842 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE---- 1897

Query: 228  KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSL---------GSV 278
                      +LAQ + +   S   +   LV    RQ   V E++ +L         G  
Sbjct: 1898 ----------RLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1946

Query: 279  QL------INDRCVDMQRSRHE-------KKKGAEEEKPKRRRQEKQAACPFYNHEQMGL 325
            +L      I     D  RS+ +       +++ A EE+ +RR  E++        E+   
Sbjct: 1947 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2006

Query: 326  LRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATR-QAAGIR 384
             R  AL EV   E+L A  +EAR       + +    QL     Q  L A  +  A  ++
Sbjct: 2007 QRKAALEEV---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2063

Query: 385  LQDQVV--IIDEAHNLIDTITG 404
             ++Q +   + +  +++D + G
Sbjct: 2064 QKEQELQQTLQQEQSVLDQLRG 2085



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 46/211 (21%), Positives = 85/211 (40%), Gaps = 19/211 (9%)

Query: 120  KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE--------RENLL 171
            K EE+ +  R  AEQ   KQR+      Q R+  +    RLR E E+         E L 
Sbjct: 1682 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1741

Query: 172  RLSREMLETGPEAERLE----QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
            RL RE      + + LE    ++ +  E L+ ++  ++EE +  S   +   + E     
Sbjct: 1742 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1801

Query: 228  KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC-- 285
            ++   +   ++L     E K+     +       +     + E + ++G    +      
Sbjct: 1802 EL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1858

Query: 286  --VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
               + +      ++ AE+E  +RRR E+QAA
Sbjct: 1859 ALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1889



 Score = 37.4 bits (85), Expect = 0.060
 Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 25/194 (12%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
            E++K ++EA+LL+  +  +   + E L   +     +             ++ Q   K E
Sbjct: 2462 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2521

Query: 123  ERDLVDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
            +    +  KA+Q R +Q R+++ Q  Q R +L  + +  R+ + E E  +R  +E     
Sbjct: 2522 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2575

Query: 182  PEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR-THSQLA 240
             E ++LEQ    +EEL+  E +         R+ E    LEE+H   + +    T SQ+A
Sbjct: 2576 -ELQQLEQQRRQQEELLAEENQ---------RLREQLQLLEEQHRAALAHSEEVTASQVA 2625

Query: 241  QFVHEVKKSPFGKD 254
                  K  P G+D
Sbjct: 2626 ----ATKTLPNGRD 2635



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 62/292 (21%), Positives = 108/292 (36%), Gaps = 39/292 (13%)

Query: 62   LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSS------SCEGAAGTPRPAG-EPAWV 114
            ++D  Q+KR+ E  L           +++   L +        E A    R A  E A  
Sbjct: 1507 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1566

Query: 115  TQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKY-AAKRLRQEEEER-ENLLR 172
             Q   +  +R     L   Q++R    E+  QL+  +Q ++ A  +LR+E E R +    
Sbjct: 1567 VQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE 1623

Query: 173  LSREMLETGPEAERLE-----------QLESGEEELVLAEYESDEEKKVASRVDEDEDDL 221
              R   E   E ER +           Q E   ++  LA+ E++++K+ A R        
Sbjct: 1624 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1683

Query: 222  EEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
            EE+ + +     +   +  Q      +     +  L+ L +       E  +     QL+
Sbjct: 1684 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-------ETEQGEQQRQLL 1736

Query: 282  NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAE 333
             +    +QR         E     ++RQE +A       E   LL  +A AE
Sbjct: 1737 EEELARLQR---------EAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1779



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 75/391 (19%), Positives = 141/391 (36%), Gaps = 48/391 (12%)

Query: 59   LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
            L+ LR     + E +  L+E         ++E L L +S E AA     AG+        
Sbjct: 1899 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1946

Query: 119  QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
                       L+ E  R +   E   + + + +L+ A +R    EEER       R   
Sbjct: 1947 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1996

Query: 179  ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
                E E   Q ++  EE+   + + +E +++  R +++               S    Q
Sbjct: 1997 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE---------------SARQLQ 2041

Query: 239  LAQFVHEVKKSPFGKDVRLVSLGSRQNL--CVNEDVKSLGSVQLINDRCVDMQRSRHEKK 296
            LAQ   + +     K          Q L   + ++   L  ++   +          E +
Sbjct: 2042 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2101

Query: 297  KGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSR 356
              AE E  + RRQ ++A     + E+    R +A A  + + +        RA     + 
Sbjct: 2102 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2161

Query: 357  LAIPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTITGMHSVEVS 411
                AA   +  ++       RQ A +      L+ Q+   D   NL+D    +  ++  
Sbjct: 2162 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAE 2219

Query: 412  GSQLCQAHSQLLQYVERYGKRLKAKNLMYLK 442
             ++  +  SQ+ +  E +  R++ + L  LK
Sbjct: 2220 ATEAARQRSQVEE--ELFSVRVQMEELSKLK 2248



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 24/97 (24%), Positives = 45/97 (46%), Gaps = 1/97 (1%)

Query: 121  KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
            +EE  L ++ +AE+  R    E   + Q ++   +A  + + E E +E   R+  E++  
Sbjct: 1349 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1408

Query: 181  GPEA-ERLEQLESGEEELVLAEYESDEEKKVASRVDE 216
               A +  +Q  S +EEL      S+ E +  +R  E
Sbjct: 1409 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1445


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 72/284 (25%), Positives = 120/284 (42%), Gaps = 35/284 (12%)

Query: 71   EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
            EEE R+    LE         + E   L +  E A    R A E A  + + VQ + +R 
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510

Query: 125  -----DLVDRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
                 +L  R+KAE    ++++  LQ L+  R+Q + A +RLRQ E ER   ++++ E  
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570

Query: 179  ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
            +   EAE    L+S             +    A +  + E  L+EEH+  +        +
Sbjct: 1571 QRSAEAE----LQS-------------KRASFAEKTAQLERSLQEEHVA-VAQLREEAER 1612

Query: 239  LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
             AQ   E +++    +  L     R  L  NE ++     + +  +    Q    ++K+ 
Sbjct: 1613 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668

Query: 299  AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
            AE E  +R + E+QA       EQ  L +   LAE    ++L A
Sbjct: 1669 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1711



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 80/376 (21%), Positives = 154/376 (40%), Gaps = 40/376 (10%)

Query: 68   KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
            + ++   R L+     +    +E+  LS + + AA   + A E     + + +K  ++ +
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316

Query: 128  DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
              ++ E  R K   E LQQ +   Q +  A+RL++++E+    L    +  +   EAER 
Sbjct: 2317 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373

Query: 188  EQLESGEE---------ELVLAEYESDEE----KKVASRVDEDEDDLEEEHITKIYYCSR 234
             QLE   E         E+  A+  ++E+    +K A  + E     E     K+     
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433

Query: 235  THSQLAQFVH------------EVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIN 282
               Q  Q  H            E +K    ++ +L+ L S +   V ++ + L   Q + 
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQ 2492

Query: 283  DRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDMEQL 340
               +  + S  ++++  E+EK K  +  Q++ A       EQ    R +   E ++ ++L
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQRL 2548

Query: 341  LALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLI 399
            +A  +EAR   +     +     +L  L  Q             RL++Q+ +++E H   
Sbjct: 2549 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR-- 2606

Query: 400  DTITGMHSVEVSGSQL 415
                  HS EV+ SQ+
Sbjct: 2607 --AALAHSEEVTASQV 2620



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 32/278 (11%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
            EQ++ EE  RL E        EK   L   +  +  A   R A E       +Q++ + +
Sbjct: 1352 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1400

Query: 126  LVDRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
            +V R +A    Q +++  +E LQQL+   + +  AK          RLR EEE R   L+
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460

Query: 173  LSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYC 232
            L     + G     L+ L +  EE    + ++ EE +   R  +DE   + +   ++   
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--AEVELA 1518

Query: 233  SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSR 292
            SR  ++      + +     +++RL +  + + L    +V+    VQ+  +       + 
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAE 1577

Query: 293  HEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEA 330
             + K+ +  EK  +  +  Q       H  +  LR+EA
Sbjct: 1578 LQSKRASFAEKTAQLERSLQE-----EHVAVAQLREEA 1610



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 89/382 (23%), Positives = 152/382 (39%), Gaps = 64/382 (16%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
            E ++ E++ +LLE     L  E   +       E      R   E    ++   ++E R 
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780

Query: 126  LVD----RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLSRE 176
              +    RL+AE  R ++  E   +L+    L   AKR RQ  EE     R    R+  E
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837

Query: 177  MLETGPEAERLE--------QLESGEEELV-LAEYESDEEKKVASRVDEDEDDLEEEHIT 227
             L    EA RL+        + E+  E L  LAE E+ + +++  +  + + D+EE    
Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE---- 1893

Query: 228  KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSL---------GSV 278
                      +LAQ + +   S   +   LV    RQ   V E++ +L         G  
Sbjct: 1894 ----------RLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942

Query: 279  QL------INDRCVDMQRSRHE-------KKKGAEEEKPKRRRQEKQAACPFYNHEQMGL 325
            +L      I     D  RS+ +       +++ A EE+ +RR  E++        E+   
Sbjct: 1943 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2002

Query: 326  LRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATR-QAAGIR 384
             R  AL EV   E+L A  +EAR       + +    QL     Q  L A  +  A  ++
Sbjct: 2003 QRKAALEEV---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059

Query: 385  LQDQVV--IIDEAHNLIDTITG 404
             ++Q +   + +  +++D + G
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRG 2081



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 46/211 (21%), Positives = 85/211 (40%), Gaps = 19/211 (9%)

Query: 120  KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE--------RENLL 171
            K EE+ +  R  AEQ   KQR+      Q R+  +    RLR E E+         E L 
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737

Query: 172  RLSREMLETGPEAERLE----QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
            RL RE      + + LE    ++ +  E L+ ++  ++EE +  S   +   + E     
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797

Query: 228  KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC-- 285
            ++   +   ++L     E K+     +       +     + E + ++G    +      
Sbjct: 1798 EL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1854

Query: 286  --VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
               + +      ++ AE+E  +RRR E+QAA
Sbjct: 1855 ALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1885



 Score = 37.4 bits (85), Expect = 0.060
 Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 25/194 (12%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
            E++K ++EA+LL+  +  +   + E L   +     +             ++ Q   K E
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2517

Query: 123  ERDLVDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
            +    +  KA+Q R +Q R+++ Q  Q R +L  + +  R+ + E E  +R  +E     
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2571

Query: 182  PEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR-THSQLA 240
             E ++LEQ    +EEL+  E +         R+ E    LEE+H   + +    T SQ+A
Sbjct: 2572 -ELQQLEQQRRQQEELLAEENQ---------RLREQLQLLEEQHRAALAHSEEVTASQVA 2621

Query: 241  QFVHEVKKSPFGKD 254
                  K  P G+D
Sbjct: 2622 ----ATKTLPNGRD 2631



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 62/292 (21%), Positives = 108/292 (36%), Gaps = 39/292 (13%)

Query: 62   LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSS------SCEGAAGTPRPAG-EPAWV 114
            ++D  Q+KR+ E  L           +++   L +        E A    R A  E A  
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562

Query: 115  TQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKY-AAKRLRQEEEER-ENLLR 172
             Q   +  +R     L   Q++R    E+  QL+  +Q ++ A  +LR+E E R +    
Sbjct: 1563 VQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE 1619

Query: 173  LSREMLETGPEAERLE-----------QLESGEEELVLAEYESDEEKKVASRVDEDEDDL 221
              R   E   E ER +           Q E   ++  LA+ E++++K+ A R        
Sbjct: 1620 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679

Query: 222  EEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
            EE+ + +     +   +  Q      +     +  L+ L +       E  +     QL+
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-------ETEQGEQQRQLL 1732

Query: 282  NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAE 333
             +    +QR         E     ++RQE +A       E   LL  +A AE
Sbjct: 1733 EEELARLQR---------EAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 75/391 (19%), Positives = 141/391 (36%), Gaps = 48/391 (12%)

Query: 59   LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
            L+ LR     + E +  L+E         ++E L L +S E AA     AG+        
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1942

Query: 119  QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
                       L+ E  R +   E   + + + +L+ A +R    EEER       R   
Sbjct: 1943 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1992

Query: 179  ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
                E E   Q ++  EE+   + + +E +++  R +++               S    Q
Sbjct: 1993 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE---------------SARQLQ 2037

Query: 239  LAQFVHEVKKSPFGKDVRLVSLGSRQNL--CVNEDVKSLGSVQLINDRCVDMQRSRHEKK 296
            LAQ   + +     K          Q L   + ++   L  ++   +          E +
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097

Query: 297  KGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSR 356
              AE E  + RRQ ++A     + E+    R +A A  + + +        RA     + 
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157

Query: 357  LAIPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTITGMHSVEVS 411
                AA   +  ++       RQ A +      L+ Q+   D   NL+D    +  ++  
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAE 2215

Query: 412  GSQLCQAHSQLLQYVERYGKRLKAKNLMYLK 442
             ++  +  SQ+ +  E +  R++ + L  LK
Sbjct: 2216 ATEAARQRSQVEE--ELFSVRVQMEELSKLK 2244



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 24/97 (24%), Positives = 45/97 (46%), Gaps = 1/97 (1%)

Query: 121  KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
            +EE  L ++ +AE+  R    E   + Q ++   +A  + + E E +E   R+  E++  
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404

Query: 181  GPEA-ERLEQLESGEEELVLAEYESDEEKKVASRVDE 216
               A +  +Q  S +EEL      S+ E +  +R  E
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1441


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 72/284 (25%), Positives = 120/284 (42%), Gaps = 35/284 (12%)

Query: 71   EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
            EEE R+    LE         + E   L +  E A    R A E A  + + VQ + +R 
Sbjct: 1419 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1478

Query: 125  -----DLVDRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
                 +L  R+KAE    ++++  LQ L+  R+Q + A +RLRQ E ER   ++++ E  
Sbjct: 1479 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1538

Query: 179  ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
            +   EAE    L+S             +    A +  + E  L+EEH+  +        +
Sbjct: 1539 QRSAEAE----LQS-------------KRASFAEKTAQLERSLQEEHVA-VAQLREEAER 1580

Query: 239  LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
             AQ   E +++    +  L     R  L  NE ++     + +  +    Q    ++K+ 
Sbjct: 1581 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1636

Query: 299  AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
            AE E  +R + E+QA       EQ  L +   LAE    ++L A
Sbjct: 1637 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1679



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 80/376 (21%), Positives = 154/376 (40%), Gaps = 40/376 (10%)

Query: 68   KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
            + ++   R L+     +    +E+  LS + + AA   + A E     + + +K  ++ +
Sbjct: 2225 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2284

Query: 128  DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
              ++ E  R K   E LQQ +   Q +  A+RL++++E+    L    +  +   EAER 
Sbjct: 2285 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341

Query: 188  EQLESGEE---------ELVLAEYESDEE----KKVASRVDEDEDDLEEEHITKIYYCSR 234
             QLE   E         E+  A+  ++E+    +K A  + E     E     K+     
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2401

Query: 235  THSQLAQFVH------------EVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIN 282
               Q  Q  H            E +K    ++ +L+ L S +   V ++ + L   Q + 
Sbjct: 2402 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQ 2460

Query: 283  DRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDMEQL 340
               +  + S  ++++  E+EK K  +  Q++ A       EQ    R +   E ++ ++L
Sbjct: 2461 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQRL 2516

Query: 341  LALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLI 399
            +A  +EAR   +     +     +L  L  Q             RL++Q+ +++E H   
Sbjct: 2517 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR-- 2574

Query: 400  DTITGMHSVEVSGSQL 415
                  HS EV+ SQ+
Sbjct: 2575 --AALAHSEEVTASQV 2588



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 32/278 (11%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
            EQ++ EE  RL E        EK   L   +  +  A   R A E       +Q++ + +
Sbjct: 1320 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1368

Query: 126  LVDRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
            +V R +A    Q +++  +E LQQL+   + +  AK          RLR EEE R   L+
Sbjct: 1369 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1428

Query: 173  LSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYC 232
            L     + G     L+ L +  EE    + ++ EE +   R  +DE   + +   ++   
Sbjct: 1429 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--AEVELA 1486

Query: 233  SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSR 292
            SR  ++      + +     +++RL +  + + L    +V+    VQ+  +       + 
Sbjct: 1487 SRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAE 1545

Query: 293  HEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEA 330
             + K+ +  EK  +  +  Q       H  +  LR+EA
Sbjct: 1546 LQSKRASFAEKTAQLERSLQE-----EHVAVAQLREEA 1578



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 89/382 (23%), Positives = 152/382 (39%), Gaps = 64/382 (16%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
            E ++ E++ +LLE     L  E   +       E      R   E    ++   ++E R 
Sbjct: 1689 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1748

Query: 126  LVD----RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLSRE 176
              +    RL+AE  R ++  E   +L+    L   AKR RQ  EE     R    R+  E
Sbjct: 1749 TSEKSKQRLEAEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAE 1805

Query: 177  MLETGPEAERLE--------QLESGEEELV-LAEYESDEEKKVASRVDEDEDDLEEEHIT 227
             L    EA RL+        + E+  E L  LAE E+ + +++  +  + + D+EE    
Sbjct: 1806 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE---- 1861

Query: 228  KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSL---------GSV 278
                      +LAQ + +   S   +   LV    RQ   V E++ +L         G  
Sbjct: 1862 ----------RLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1910

Query: 279  QL------INDRCVDMQRSRHE-------KKKGAEEEKPKRRRQEKQAACPFYNHEQMGL 325
            +L      I     D  RS+ +       +++ A EE+ +RR  E++        E+   
Sbjct: 1911 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1970

Query: 326  LRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATR-QAAGIR 384
             R  AL EV   E+L A  +EAR       + +    QL     Q  L A  +  A  ++
Sbjct: 1971 QRKAALEEV---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2027

Query: 385  LQDQVV--IIDEAHNLIDTITG 404
             ++Q +   + +  +++D + G
Sbjct: 2028 QKEQELQQTLQQEQSVLDQLRG 2049



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 46/211 (21%), Positives = 85/211 (40%), Gaps = 19/211 (9%)

Query: 120  KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE--------RENLL 171
            K EE+ +  R  AEQ   KQR+      Q R+  +    RLR E E+         E L 
Sbjct: 1646 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1705

Query: 172  RLSREMLETGPEAERLE----QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
            RL RE      + + LE    ++ +  E L+ ++  ++EE +  S   +   + E     
Sbjct: 1706 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1765

Query: 228  KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC-- 285
            ++   +   ++L     E K+     +       +     + E + ++G    +      
Sbjct: 1766 EL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1822

Query: 286  --VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
               + +      ++ AE+E  +RRR E+QAA
Sbjct: 1823 ALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1853



 Score = 37.4 bits (85), Expect = 0.060
 Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 25/194 (12%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
            E++K ++EA+LL+  +  +   + E L   +     +             ++ Q   K E
Sbjct: 2426 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2485

Query: 123  ERDLVDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
            +    +  KA+Q R +Q R+++ Q  Q R +L  + +  R+ + E E  +R  +E     
Sbjct: 2486 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2539

Query: 182  PEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR-THSQLA 240
             E ++LEQ    +EEL+  E +         R+ E    LEE+H   + +    T SQ+A
Sbjct: 2540 -ELQQLEQQRRQQEELLAEENQ---------RLREQLQLLEEQHRAALAHSEEVTASQVA 2589

Query: 241  QFVHEVKKSPFGKD 254
                  K  P G+D
Sbjct: 2590 ----ATKTLPNGRD 2599



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 62/292 (21%), Positives = 108/292 (36%), Gaps = 39/292 (13%)

Query: 62   LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSS------SCEGAAGTPRPAG-EPAWV 114
            ++D  Q+KR+ E  L           +++   L +        E A    R A  E A  
Sbjct: 1471 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1530

Query: 115  TQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKY-AAKRLRQEEEER-ENLLR 172
             Q   +  +R     L   Q++R    E+  QL+  +Q ++ A  +LR+E E R +    
Sbjct: 1531 VQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE 1587

Query: 173  LSREMLETGPEAERLE-----------QLESGEEELVLAEYESDEEKKVASRVDEDEDDL 221
              R   E   E ER +           Q E   ++  LA+ E++++K+ A R        
Sbjct: 1588 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1647

Query: 222  EEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
            EE+ + +     +   +  Q      +     +  L+ L +       E  +     QL+
Sbjct: 1648 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-------ETEQGEQQRQLL 1700

Query: 282  NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAE 333
             +    +QR         E     ++RQE +A       E   LL  +A AE
Sbjct: 1701 EEELARLQR---------EAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1743



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 75/391 (19%), Positives = 141/391 (36%), Gaps = 48/391 (12%)

Query: 59   LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
            L+ LR     + E +  L+E         ++E L L +S E AA     AG+        
Sbjct: 1863 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1910

Query: 119  QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
                       L+ E  R +   E   + + + +L+ A +R    EEER       R   
Sbjct: 1911 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1960

Query: 179  ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
                E E   Q ++  EE+   + + +E +++  R +++               S    Q
Sbjct: 1961 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE---------------SARQLQ 2005

Query: 239  LAQFVHEVKKSPFGKDVRLVSLGSRQNL--CVNEDVKSLGSVQLINDRCVDMQRSRHEKK 296
            LAQ   + +     K          Q L   + ++   L  ++   +          E +
Sbjct: 2006 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2065

Query: 297  KGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSR 356
              AE E  + RRQ ++A     + E+    R +A A  + + +        RA     + 
Sbjct: 2066 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2125

Query: 357  LAIPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTITGMHSVEVS 411
                AA   +  ++       RQ A +      L+ Q+   D   NL+D    +  ++  
Sbjct: 2126 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAE 2183

Query: 412  GSQLCQAHSQLLQYVERYGKRLKAKNLMYLK 442
             ++  +  SQ+ +  E +  R++ + L  LK
Sbjct: 2184 ATEAARQRSQVEE--ELFSVRVQMEELSKLK 2212



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 24/97 (24%), Positives = 45/97 (46%), Gaps = 1/97 (1%)

Query: 121  KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
            +EE  L ++ +AE+  R    E   + Q ++   +A  + + E E +E   R+  E++  
Sbjct: 1313 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1372

Query: 181  GPEA-ERLEQLESGEEELVLAEYESDEEKKVASRVDE 216
               A +  +Q  S +EEL      S+ E +  +R  E
Sbjct: 1373 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1409


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 72/284 (25%), Positives = 120/284 (42%), Gaps = 35/284 (12%)

Query: 71   EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
            EEE R+    LE         + E   L +  E A    R A E A  + + VQ + +R 
Sbjct: 1588 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1647

Query: 125  -----DLVDRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
                 +L  R+KAE    ++++  LQ L+  R+Q + A +RLRQ E ER   ++++ E  
Sbjct: 1648 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1707

Query: 179  ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
            +   EAE    L+S             +    A +  + E  L+EEH+  +        +
Sbjct: 1708 QRSAEAE----LQS-------------KRASFAEKTAQLERSLQEEHVA-VAQLREEAER 1749

Query: 239  LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
             AQ   E +++    +  L     R  L  NE ++     + +  +    Q    ++K+ 
Sbjct: 1750 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1805

Query: 299  AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
            AE E  +R + E+QA       EQ  L +   LAE    ++L A
Sbjct: 1806 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1848



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 80/376 (21%), Positives = 154/376 (40%), Gaps = 40/376 (10%)

Query: 68   KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
            + ++   R L+     +    +E+  LS + + AA   + A E     + + +K  ++ +
Sbjct: 2394 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2453

Query: 128  DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
              ++ E  R K   E LQQ +   Q +  A+RL++++E+    L    +  +   EAER 
Sbjct: 2454 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510

Query: 188  EQLESGEE---------ELVLAEYESDEE----KKVASRVDEDEDDLEEEHITKIYYCSR 234
             QLE   E         E+  A+  ++E+    +K A  + E     E     K+     
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2570

Query: 235  THSQLAQFVH------------EVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIN 282
               Q  Q  H            E +K    ++ +L+ L S +   V ++ + L   Q + 
Sbjct: 2571 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQ 2629

Query: 283  DRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDMEQL 340
               +  + S  ++++  E+EK K  +  Q++ A       EQ    R +   E ++ ++L
Sbjct: 2630 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQRL 2685

Query: 341  LALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLI 399
            +A  +EAR   +     +     +L  L  Q             RL++Q+ +++E H   
Sbjct: 2686 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR-- 2743

Query: 400  DTITGMHSVEVSGSQL 415
                  HS EV+ SQ+
Sbjct: 2744 --AALAHSEEVTASQV 2757



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 32/278 (11%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
            EQ++ EE  RL E        EK   L   +  +  A   R A E       +Q++ + +
Sbjct: 1489 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1537

Query: 126  LVDRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
            +V R +A    Q +++  +E LQQL+   + +  AK          RLR EEE R   L+
Sbjct: 1538 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1597

Query: 173  LSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYC 232
            L     + G     L+ L +  EE    + ++ EE +   R  +DE   + +   ++   
Sbjct: 1598 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--AEVELA 1655

Query: 233  SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSR 292
            SR  ++      + +     +++RL +  + + L    +V+    VQ+  +       + 
Sbjct: 1656 SRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAE 1714

Query: 293  HEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEA 330
             + K+ +  EK  +  +  Q       H  +  LR+EA
Sbjct: 1715 LQSKRASFAEKTAQLERSLQE-----EHVAVAQLREEA 1747



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 89/382 (23%), Positives = 152/382 (39%), Gaps = 64/382 (16%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
            E ++ E++ +LLE     L  E   +       E      R   E    ++   ++E R 
Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1917

Query: 126  LVD----RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLSRE 176
              +    RL+AE  R ++  E   +L+    L   AKR RQ  EE     R    R+  E
Sbjct: 1918 TSEKSKQRLEAEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAE 1974

Query: 177  MLETGPEAERLE--------QLESGEEELV-LAEYESDEEKKVASRVDEDEDDLEEEHIT 227
             L    EA RL+        + E+  E L  LAE E+ + +++  +  + + D+EE    
Sbjct: 1975 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE---- 2030

Query: 228  KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSL---------GSV 278
                      +LAQ + +   S   +   LV    RQ   V E++ +L         G  
Sbjct: 2031 ----------RLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 2079

Query: 279  QL------INDRCVDMQRSRHE-------KKKGAEEEKPKRRRQEKQAACPFYNHEQMGL 325
            +L      I     D  RS+ +       +++ A EE+ +RR  E++        E+   
Sbjct: 2080 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2139

Query: 326  LRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATR-QAAGIR 384
             R  AL EV   E+L A  +EAR       + +    QL     Q  L A  +  A  ++
Sbjct: 2140 QRKAALEEV---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2196

Query: 385  LQDQVV--IIDEAHNLIDTITG 404
             ++Q +   + +  +++D + G
Sbjct: 2197 QKEQELQQTLQQEQSVLDQLRG 2218



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 46/211 (21%), Positives = 85/211 (40%), Gaps = 19/211 (9%)

Query: 120  KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE--------RENLL 171
            K EE+ +  R  AEQ   KQR+      Q R+  +    RLR E E+         E L 
Sbjct: 1815 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1874

Query: 172  RLSREMLETGPEAERLE----QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
            RL RE      + + LE    ++ +  E L+ ++  ++EE +  S   +   + E     
Sbjct: 1875 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1934

Query: 228  KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC-- 285
            ++   +   ++L     E K+     +       +     + E + ++G    +      
Sbjct: 1935 EL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1991

Query: 286  --VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
               + +      ++ AE+E  +RRR E+QAA
Sbjct: 1992 ALKEKEAENERLRRLAEDEAFQRRRLEEQAA 2022



 Score = 37.4 bits (85), Expect = 0.060
 Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 25/194 (12%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
            E++K ++EA+LL+  +  +   + E L   +     +             ++ Q   K E
Sbjct: 2595 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2654

Query: 123  ERDLVDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
            +    +  KA+Q R +Q R+++ Q  Q R +L  + +  R+ + E E  +R  +E     
Sbjct: 2655 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2708

Query: 182  PEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR-THSQLA 240
             E ++LEQ    +EEL+  E +         R+ E    LEE+H   + +    T SQ+A
Sbjct: 2709 -ELQQLEQQRRQQEELLAEENQ---------RLREQLQLLEEQHRAALAHSEEVTASQVA 2758

Query: 241  QFVHEVKKSPFGKD 254
                  K  P G+D
Sbjct: 2759 ----ATKTLPNGRD 2768



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 62/292 (21%), Positives = 108/292 (36%), Gaps = 39/292 (13%)

Query: 62   LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSS------SCEGAAGTPRPAG-EPAWV 114
            ++D  Q+KR+ E  L           +++   L +        E A    R A  E A  
Sbjct: 1640 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1699

Query: 115  TQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKY-AAKRLRQEEEER-ENLLR 172
             Q   +  +R     L   Q++R    E+  QL+  +Q ++ A  +LR+E E R +    
Sbjct: 1700 VQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE 1756

Query: 173  LSREMLETGPEAERLE-----------QLESGEEELVLAEYESDEEKKVASRVDEDEDDL 221
              R   E   E ER +           Q E   ++  LA+ E++++K+ A R        
Sbjct: 1757 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1816

Query: 222  EEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
            EE+ + +     +   +  Q      +     +  L+ L +       E  +     QL+
Sbjct: 1817 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-------ETEQGEQQRQLL 1869

Query: 282  NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAE 333
             +    +QR         E     ++RQE +A       E   LL  +A AE
Sbjct: 1870 EEELARLQR---------EAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1912



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 75/391 (19%), Positives = 141/391 (36%), Gaps = 48/391 (12%)

Query: 59   LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
            L+ LR     + E +  L+E         ++E L L +S E AA     AG+        
Sbjct: 2032 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 2079

Query: 119  QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
                       L+ E  R +   E   + + + +L+ A +R    EEER       R   
Sbjct: 2080 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 2129

Query: 179  ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
                E E   Q ++  EE+   + + +E +++  R +++               S    Q
Sbjct: 2130 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE---------------SARQLQ 2174

Query: 239  LAQFVHEVKKSPFGKDVRLVSLGSRQNL--CVNEDVKSLGSVQLINDRCVDMQRSRHEKK 296
            LAQ   + +     K          Q L   + ++   L  ++   +          E +
Sbjct: 2175 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2234

Query: 297  KGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSR 356
              AE E  + RRQ ++A     + E+    R +A A  + + +        RA     + 
Sbjct: 2235 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2294

Query: 357  LAIPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTITGMHSVEVS 411
                AA   +  ++       RQ A +      L+ Q+   D   NL+D    +  ++  
Sbjct: 2295 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAE 2352

Query: 412  GSQLCQAHSQLLQYVERYGKRLKAKNLMYLK 442
             ++  +  SQ+ +  E +  R++ + L  LK
Sbjct: 2353 ATEAARQRSQVEE--ELFSVRVQMEELSKLK 2381



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 24/97 (24%), Positives = 45/97 (46%), Gaps = 1/97 (1%)

Query: 121  KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
            +EE  L ++ +AE+  R    E   + Q ++   +A  + + E E +E   R+  E++  
Sbjct: 1482 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1541

Query: 181  GPEA-ERLEQLESGEEELVLAEYESDEEKKVASRVDE 216
               A +  +Q  S +EEL      S+ E +  +R  E
Sbjct: 1542 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1578


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 72/284 (25%), Positives = 120/284 (42%), Gaps = 35/284 (12%)

Query: 71   EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
            EEE R+    LE         + E   L +  E A    R A E A  + + VQ + +R 
Sbjct: 1429 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1488

Query: 125  -----DLVDRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
                 +L  R+KAE    ++++  LQ L+  R+Q + A +RLRQ E ER   ++++ E  
Sbjct: 1489 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1548

Query: 179  ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
            +   EAE    L+S             +    A +  + E  L+EEH+  +        +
Sbjct: 1549 QRSAEAE----LQS-------------KRASFAEKTAQLERSLQEEHVA-VAQLREEAER 1590

Query: 239  LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
             AQ   E +++    +  L     R  L  NE ++     + +  +    Q    ++K+ 
Sbjct: 1591 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1646

Query: 299  AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
            AE E  +R + E+QA       EQ  L +   LAE    ++L A
Sbjct: 1647 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1689



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 80/376 (21%), Positives = 154/376 (40%), Gaps = 40/376 (10%)

Query: 68   KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
            + ++   R L+     +    +E+  LS + + AA   + A E     + + +K  ++ +
Sbjct: 2235 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2294

Query: 128  DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
              ++ E  R K   E LQQ +   Q +  A+RL++++E+    L    +  +   EAER 
Sbjct: 2295 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351

Query: 188  EQLESGEE---------ELVLAEYESDEE----KKVASRVDEDEDDLEEEHITKIYYCSR 234
             QLE   E         E+  A+  ++E+    +K A  + E     E     K+     
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2411

Query: 235  THSQLAQFVH------------EVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIN 282
               Q  Q  H            E +K    ++ +L+ L S +   V ++ + L   Q + 
Sbjct: 2412 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQ 2470

Query: 283  DRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDMEQL 340
               +  + S  ++++  E+EK K  +  Q++ A       EQ    R +   E ++ ++L
Sbjct: 2471 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQRL 2526

Query: 341  LALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLI 399
            +A  +EAR   +     +     +L  L  Q             RL++Q+ +++E H   
Sbjct: 2527 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR-- 2584

Query: 400  DTITGMHSVEVSGSQL 415
                  HS EV+ SQ+
Sbjct: 2585 --AALAHSEEVTASQV 2598



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 32/278 (11%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
            EQ++ EE  RL E        EK   L   +  +  A   R A E       +Q++ + +
Sbjct: 1330 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1378

Query: 126  LVDRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
            +V R +A    Q +++  +E LQQL+   + +  AK          RLR EEE R   L+
Sbjct: 1379 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1438

Query: 173  LSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYC 232
            L     + G     L+ L +  EE    + ++ EE +   R  +DE   + +   ++   
Sbjct: 1439 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--AEVELA 1496

Query: 233  SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSR 292
            SR  ++      + +     +++RL +  + + L    +V+    VQ+  +       + 
Sbjct: 1497 SRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAE 1555

Query: 293  HEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEA 330
             + K+ +  EK  +  +  Q       H  +  LR+EA
Sbjct: 1556 LQSKRASFAEKTAQLERSLQE-----EHVAVAQLREEA 1588



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 89/382 (23%), Positives = 152/382 (39%), Gaps = 64/382 (16%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
            E ++ E++ +LLE     L  E   +       E      R   E    ++   ++E R 
Sbjct: 1699 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1758

Query: 126  LVD----RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLSRE 176
              +    RL+AE  R ++  E   +L+    L   AKR RQ  EE     R    R+  E
Sbjct: 1759 TSEKSKQRLEAEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAE 1815

Query: 177  MLETGPEAERLE--------QLESGEEELV-LAEYESDEEKKVASRVDEDEDDLEEEHIT 227
             L    EA RL+        + E+  E L  LAE E+ + +++  +  + + D+EE    
Sbjct: 1816 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE---- 1871

Query: 228  KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSL---------GSV 278
                      +LAQ + +   S   +   LV    RQ   V E++ +L         G  
Sbjct: 1872 ----------RLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920

Query: 279  QL------INDRCVDMQRSRHE-------KKKGAEEEKPKRRRQEKQAACPFYNHEQMGL 325
            +L      I     D  RS+ +       +++ A EE+ +RR  E++        E+   
Sbjct: 1921 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1980

Query: 326  LRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATR-QAAGIR 384
             R  AL EV   E+L A  +EAR       + +    QL     Q  L A  +  A  ++
Sbjct: 1981 QRKAALEEV---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2037

Query: 385  LQDQVV--IIDEAHNLIDTITG 404
             ++Q +   + +  +++D + G
Sbjct: 2038 QKEQELQQTLQQEQSVLDQLRG 2059



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 46/211 (21%), Positives = 85/211 (40%), Gaps = 19/211 (9%)

Query: 120  KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE--------RENLL 171
            K EE+ +  R  AEQ   KQR+      Q R+  +    RLR E E+         E L 
Sbjct: 1656 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1715

Query: 172  RLSREMLETGPEAERLE----QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
            RL RE      + + LE    ++ +  E L+ ++  ++EE +  S   +   + E     
Sbjct: 1716 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1775

Query: 228  KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC-- 285
            ++   +   ++L     E K+     +       +     + E + ++G    +      
Sbjct: 1776 EL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1832

Query: 286  --VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
               + +      ++ AE+E  +RRR E+QAA
Sbjct: 1833 ALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1863



 Score = 37.4 bits (85), Expect = 0.060
 Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 25/194 (12%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
            E++K ++EA+LL+  +  +   + E L   +     +             ++ Q   K E
Sbjct: 2436 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2495

Query: 123  ERDLVDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
            +    +  KA+Q R +Q R+++ Q  Q R +L  + +  R+ + E E  +R  +E     
Sbjct: 2496 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2549

Query: 182  PEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR-THSQLA 240
             E ++LEQ    +EEL+  E +         R+ E    LEE+H   + +    T SQ+A
Sbjct: 2550 -ELQQLEQQRRQQEELLAEENQ---------RLREQLQLLEEQHRAALAHSEEVTASQVA 2599

Query: 241  QFVHEVKKSPFGKD 254
                  K  P G+D
Sbjct: 2600 ----ATKTLPNGRD 2609



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 62/292 (21%), Positives = 108/292 (36%), Gaps = 39/292 (13%)

Query: 62   LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSS------SCEGAAGTPRPAG-EPAWV 114
            ++D  Q+KR+ E  L           +++   L +        E A    R A  E A  
Sbjct: 1481 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1540

Query: 115  TQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKY-AAKRLRQEEEER-ENLLR 172
             Q   +  +R     L   Q++R    E+  QL+  +Q ++ A  +LR+E E R +    
Sbjct: 1541 VQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE 1597

Query: 173  LSREMLETGPEAERLE-----------QLESGEEELVLAEYESDEEKKVASRVDEDEDDL 221
              R   E   E ER +           Q E   ++  LA+ E++++K+ A R        
Sbjct: 1598 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1657

Query: 222  EEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
            EE+ + +     +   +  Q      +     +  L+ L +       E  +     QL+
Sbjct: 1658 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-------ETEQGEQQRQLL 1710

Query: 282  NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAE 333
             +    +QR         E     ++RQE +A       E   LL  +A AE
Sbjct: 1711 EEELARLQR---------EAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1753



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 75/391 (19%), Positives = 141/391 (36%), Gaps = 48/391 (12%)

Query: 59   LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
            L+ LR     + E +  L+E         ++E L L +S E AA     AG+        
Sbjct: 1873 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1920

Query: 119  QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
                       L+ E  R +   E   + + + +L+ A +R    EEER       R   
Sbjct: 1921 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1970

Query: 179  ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
                E E   Q ++  EE+   + + +E +++  R +++               S    Q
Sbjct: 1971 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE---------------SARQLQ 2015

Query: 239  LAQFVHEVKKSPFGKDVRLVSLGSRQNL--CVNEDVKSLGSVQLINDRCVDMQRSRHEKK 296
            LAQ   + +     K          Q L   + ++   L  ++   +          E +
Sbjct: 2016 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2075

Query: 297  KGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSR 356
              AE E  + RRQ ++A     + E+    R +A A  + + +        RA     + 
Sbjct: 2076 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2135

Query: 357  LAIPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTITGMHSVEVS 411
                AA   +  ++       RQ A +      L+ Q+   D   NL+D    +  ++  
Sbjct: 2136 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAE 2193

Query: 412  GSQLCQAHSQLLQYVERYGKRLKAKNLMYLK 442
             ++  +  SQ+ +  E +  R++ + L  LK
Sbjct: 2194 ATEAARQRSQVEE--ELFSVRVQMEELSKLK 2222



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 24/97 (24%), Positives = 45/97 (46%), Gaps = 1/97 (1%)

Query: 121  KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
            +EE  L ++ +AE+  R    E   + Q ++   +A  + + E E +E   R+  E++  
Sbjct: 1323 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1382

Query: 181  GPEA-ERLEQLESGEEELVLAEYESDEEKKVASRVDE 216
               A +  +Q  S +EEL      S+ E +  +R  E
Sbjct: 1383 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1419


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 72/284 (25%), Positives = 120/284 (42%), Gaps = 35/284 (12%)

Query: 71   EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
            EEE R+    LE         + E   L +  E A    R A E A  + + VQ + +R 
Sbjct: 1437 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1496

Query: 125  -----DLVDRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
                 +L  R+KAE    ++++  LQ L+  R+Q + A +RLRQ E ER   ++++ E  
Sbjct: 1497 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1556

Query: 179  ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
            +   EAE    L+S             +    A +  + E  L+EEH+  +        +
Sbjct: 1557 QRSAEAE----LQS-------------KRASFAEKTAQLERSLQEEHVA-VAQLREEAER 1598

Query: 239  LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
             AQ   E +++    +  L     R  L  NE ++     + +  +    Q    ++K+ 
Sbjct: 1599 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1654

Query: 299  AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
            AE E  +R + E+QA       EQ  L +   LAE    ++L A
Sbjct: 1655 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1697



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 80/376 (21%), Positives = 154/376 (40%), Gaps = 40/376 (10%)

Query: 68   KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
            + ++   R L+     +    +E+  LS + + AA   + A E     + + +K  ++ +
Sbjct: 2243 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2302

Query: 128  DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
              ++ E  R K   E LQQ +   Q +  A+RL++++E+    L    +  +   EAER 
Sbjct: 2303 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2359

Query: 188  EQLESGEE---------ELVLAEYESDEE----KKVASRVDEDEDDLEEEHITKIYYCSR 234
             QLE   E         E+  A+  ++E+    +K A  + E     E     K+     
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2419

Query: 235  THSQLAQFVH------------EVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIN 282
               Q  Q  H            E +K    ++ +L+ L S +   V ++ + L   Q + 
Sbjct: 2420 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQ 2478

Query: 283  DRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDMEQL 340
               +  + S  ++++  E+EK K  +  Q++ A       EQ    R +   E ++ ++L
Sbjct: 2479 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQRL 2534

Query: 341  LALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLI 399
            +A  +EAR   +     +     +L  L  Q             RL++Q+ +++E H   
Sbjct: 2535 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR-- 2592

Query: 400  DTITGMHSVEVSGSQL 415
                  HS EV+ SQ+
Sbjct: 2593 --AALAHSEEVTASQV 2606



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 32/278 (11%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
            EQ++ EE  RL E        EK   L   +  +  A   R A E       +Q++ + +
Sbjct: 1338 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1386

Query: 126  LVDRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
            +V R +A    Q +++  +E LQQL+   + +  AK          RLR EEE R   L+
Sbjct: 1387 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1446

Query: 173  LSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYC 232
            L     + G     L+ L +  EE    + ++ EE +   R  +DE   + +   ++   
Sbjct: 1447 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--AEVELA 1504

Query: 233  SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSR 292
            SR  ++      + +     +++RL +  + + L    +V+    VQ+  +       + 
Sbjct: 1505 SRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAE 1563

Query: 293  HEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEA 330
             + K+ +  EK  +  +  Q       H  +  LR+EA
Sbjct: 1564 LQSKRASFAEKTAQLERSLQE-----EHVAVAQLREEA 1596



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 89/382 (23%), Positives = 152/382 (39%), Gaps = 64/382 (16%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
            E ++ E++ +LLE     L  E   +       E      R   E    ++   ++E R 
Sbjct: 1707 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1766

Query: 126  LVD----RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLSRE 176
              +    RL+AE  R ++  E   +L+    L   AKR RQ  EE     R    R+  E
Sbjct: 1767 TSEKSKQRLEAEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAE 1823

Query: 177  MLETGPEAERLE--------QLESGEEELV-LAEYESDEEKKVASRVDEDEDDLEEEHIT 227
             L    EA RL+        + E+  E L  LAE E+ + +++  +  + + D+EE    
Sbjct: 1824 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE---- 1879

Query: 228  KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSL---------GSV 278
                      +LAQ + +   S   +   LV    RQ   V E++ +L         G  
Sbjct: 1880 ----------RLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1928

Query: 279  QL------INDRCVDMQRSRHE-------KKKGAEEEKPKRRRQEKQAACPFYNHEQMGL 325
            +L      I     D  RS+ +       +++ A EE+ +RR  E++        E+   
Sbjct: 1929 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1988

Query: 326  LRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATR-QAAGIR 384
             R  AL EV   E+L A  +EAR       + +    QL     Q  L A  +  A  ++
Sbjct: 1989 QRKAALEEV---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2045

Query: 385  LQDQVV--IIDEAHNLIDTITG 404
             ++Q +   + +  +++D + G
Sbjct: 2046 QKEQELQQTLQQEQSVLDQLRG 2067



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 46/211 (21%), Positives = 85/211 (40%), Gaps = 19/211 (9%)

Query: 120  KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE--------RENLL 171
            K EE+ +  R  AEQ   KQR+      Q R+  +    RLR E E+         E L 
Sbjct: 1664 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1723

Query: 172  RLSREMLETGPEAERLE----QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
            RL RE      + + LE    ++ +  E L+ ++  ++EE +  S   +   + E     
Sbjct: 1724 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1783

Query: 228  KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC-- 285
            ++   +   ++L     E K+     +       +     + E + ++G    +      
Sbjct: 1784 EL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1840

Query: 286  --VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
               + +      ++ AE+E  +RRR E+QAA
Sbjct: 1841 ALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1871



 Score = 37.4 bits (85), Expect = 0.060
 Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 25/194 (12%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
            E++K ++EA+LL+  +  +   + E L   +     +             ++ Q   K E
Sbjct: 2444 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2503

Query: 123  ERDLVDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
            +    +  KA+Q R +Q R+++ Q  Q R +L  + +  R+ + E E  +R  +E     
Sbjct: 2504 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2557

Query: 182  PEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR-THSQLA 240
             E ++LEQ    +EEL+  E +         R+ E    LEE+H   + +    T SQ+A
Sbjct: 2558 -ELQQLEQQRRQQEELLAEENQ---------RLREQLQLLEEQHRAALAHSEEVTASQVA 2607

Query: 241  QFVHEVKKSPFGKD 254
                  K  P G+D
Sbjct: 2608 ----ATKTLPNGRD 2617



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 62/292 (21%), Positives = 108/292 (36%), Gaps = 39/292 (13%)

Query: 62   LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSS------SCEGAAGTPRPAG-EPAWV 114
            ++D  Q+KR+ E  L           +++   L +        E A    R A  E A  
Sbjct: 1489 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1548

Query: 115  TQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKY-AAKRLRQEEEER-ENLLR 172
             Q   +  +R     L   Q++R    E+  QL+  +Q ++ A  +LR+E E R +    
Sbjct: 1549 VQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE 1605

Query: 173  LSREMLETGPEAERLE-----------QLESGEEELVLAEYESDEEKKVASRVDEDEDDL 221
              R   E   E ER +           Q E   ++  LA+ E++++K+ A R        
Sbjct: 1606 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1665

Query: 222  EEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
            EE+ + +     +   +  Q      +     +  L+ L +       E  +     QL+
Sbjct: 1666 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-------ETEQGEQQRQLL 1718

Query: 282  NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAE 333
             +    +QR         E     ++RQE +A       E   LL  +A AE
Sbjct: 1719 EEELARLQR---------EAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1761



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 75/391 (19%), Positives = 141/391 (36%), Gaps = 48/391 (12%)

Query: 59   LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
            L+ LR     + E +  L+E         ++E L L +S E AA     AG+        
Sbjct: 1881 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1928

Query: 119  QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
                       L+ E  R +   E   + + + +L+ A +R    EEER       R   
Sbjct: 1929 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1978

Query: 179  ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
                E E   Q ++  EE+   + + +E +++  R +++               S    Q
Sbjct: 1979 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE---------------SARQLQ 2023

Query: 239  LAQFVHEVKKSPFGKDVRLVSLGSRQNL--CVNEDVKSLGSVQLINDRCVDMQRSRHEKK 296
            LAQ   + +     K          Q L   + ++   L  ++   +          E +
Sbjct: 2024 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2083

Query: 297  KGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSR 356
              AE E  + RRQ ++A     + E+    R +A A  + + +        RA     + 
Sbjct: 2084 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2143

Query: 357  LAIPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTITGMHSVEVS 411
                AA   +  ++       RQ A +      L+ Q+   D   NL+D    +  ++  
Sbjct: 2144 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAE 2201

Query: 412  GSQLCQAHSQLLQYVERYGKRLKAKNLMYLK 442
             ++  +  SQ+ +  E +  R++ + L  LK
Sbjct: 2202 ATEAARQRSQVEE--ELFSVRVQMEELSKLK 2230



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 24/97 (24%), Positives = 45/97 (46%), Gaps = 1/97 (1%)

Query: 121  KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
            +EE  L ++ +AE+  R    E   + Q ++   +A  + + E E +E   R+  E++  
Sbjct: 1331 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1390

Query: 181  GPEA-ERLEQLESGEEELVLAEYESDEEKKVASRVDE 216
               A +  +Q  S +EEL      S+ E +  +R  E
Sbjct: 1391 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1427


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 72/284 (25%), Positives = 120/284 (42%), Gaps = 35/284 (12%)

Query: 71   EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 124
            EEE R+    LE         + E   L +  E A    R A E A  + + VQ + +R 
Sbjct: 1478 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1537

Query: 125  -----DLVDRLKAEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEERENLLRLSREML 178
                 +L  R+KAE    ++++  LQ L+  R+Q + A +RLRQ E ER   ++++ E  
Sbjct: 1538 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1597

Query: 179  ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
            +   EAE    L+S             +    A +  + E  L+EEH+  +        +
Sbjct: 1598 QRSAEAE----LQS-------------KRASFAEKTAQLERSLQEEHVA-VAQLREEAER 1639

Query: 239  LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKG 298
             AQ   E +++    +  L     R  L  NE ++     + +  +    Q    ++K+ 
Sbjct: 1640 RAQQQAEAERAREEAEREL----ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1695

Query: 299  AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLA 342
            AE E  +R + E+QA       EQ  L +   LAE    ++L A
Sbjct: 1696 AEREARRRGKAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAA 1738



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 80/376 (21%), Positives = 154/376 (40%), Gaps = 40/376 (10%)

Query: 68   KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 127
            + ++   R L+     +    +E+  LS + + AA   + A E     + + +K  ++ +
Sbjct: 2284 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2343

Query: 128  DRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERL 187
              ++ E  R K   E LQQ +   Q +  A+RL++++E+    L    +  +   EAER 
Sbjct: 2344 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400

Query: 188  EQLESGEE---------ELVLAEYESDEE----KKVASRVDEDEDDLEEEHITKIYYCSR 234
             QLE   E         E+  A+  ++E+    +K A  + E     E     K+     
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2460

Query: 235  THSQLAQFVH------------EVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIN 282
               Q  Q  H            E +K    ++ +L+ L S +   V ++ + L   Q + 
Sbjct: 2461 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQ 2519

Query: 283  DRCVDMQRSRHEKKKGAEEEKPKRRR--QEKQAACPFYNHEQMGLLRDEALAEVKDMEQL 340
               +  + S  ++++  E+EK K  +  Q++ A       EQ    R +   E ++ ++L
Sbjct: 2520 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQME-QERQRL 2575

Query: 341  LALGKEARACPYYGSR-LAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLI 399
            +A  +EAR   +     +     +L  L  Q             RL++Q+ +++E H   
Sbjct: 2576 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR-- 2633

Query: 400  DTITGMHSVEVSGSQL 415
                  HS EV+ SQ+
Sbjct: 2634 --AALAHSEEVTASQV 2647



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 62/278 (22%), Positives = 115/278 (41%), Gaps = 32/278 (11%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
            EQ++ EE  RL E        EK   L   +  +  A   R A E       +Q++ + +
Sbjct: 1379 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1427

Query: 126  LVDRLKAE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEERENLLR 172
            +V R +A    Q +++  +E LQQL+   + +  AK          RLR EEE R   L+
Sbjct: 1428 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1487

Query: 173  LSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYC 232
            L     + G     L+ L +  EE    + ++ EE +   R  +DE   + +   ++   
Sbjct: 1488 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--AEVELA 1545

Query: 233  SRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSR 292
            SR  ++      + +     +++RL +  + + L    +V+    VQ+  +       + 
Sbjct: 1546 SRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAE 1604

Query: 293  HEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEA 330
             + K+ +  EK  +  +  Q       H  +  LR+EA
Sbjct: 1605 LQSKRASFAEKTAQLERSLQE-----EHVAVAQLREEA 1637



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 89/382 (23%), Positives = 152/382 (39%), Gaps = 64/382 (16%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 125
            E ++ E++ +LLE     L  E   +       E      R   E    ++   ++E R 
Sbjct: 1748 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1807

Query: 126  LVD----RLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----RENLLRLSRE 176
              +    RL+AE  R ++  E   +L+    L   AKR RQ  EE     R    R+  E
Sbjct: 1808 TSEKSKQRLEAEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAE 1864

Query: 177  MLETGPEAERLE--------QLESGEEELV-LAEYESDEEKKVASRVDEDEDDLEEEHIT 227
             L    EA RL+        + E+  E L  LAE E+ + +++  +  + + D+EE    
Sbjct: 1865 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE---- 1920

Query: 228  KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSL---------GSV 278
                      +LAQ + +   S   +   LV    RQ   V E++ +L         G  
Sbjct: 1921 ----------RLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1969

Query: 279  QL------INDRCVDMQRSRHE-------KKKGAEEEKPKRRRQEKQAACPFYNHEQMGL 325
            +L      I     D  RS+ +       +++ A EE+ +RR  E++        E+   
Sbjct: 1970 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2029

Query: 326  LRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATR-QAAGIR 384
             R  AL EV   E+L A  +EAR       + +    QL     Q  L A  +  A  ++
Sbjct: 2030 QRKAALEEV---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2086

Query: 385  LQDQVV--IIDEAHNLIDTITG 404
             ++Q +   + +  +++D + G
Sbjct: 2087 QKEQELQQTLQQEQSVLDQLRG 2108



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 46/211 (21%), Positives = 85/211 (40%), Gaps = 19/211 (9%)

Query: 120  KKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE--------RENLL 171
            K EE+ +  R  AEQ   KQR+      Q R+  +    RLR E E+         E L 
Sbjct: 1705 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1764

Query: 172  RLSREMLETGPEAERLE----QLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHIT 227
            RL RE      + + LE    ++ +  E L+ ++  ++EE +  S   +   + E     
Sbjct: 1765 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1824

Query: 228  KIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRC-- 285
            ++   +   ++L     E K+     +       +     + E + ++G    +      
Sbjct: 1825 EL---AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1881

Query: 286  --VDMQRSRHEKKKGAEEEKPKRRRQEKQAA 314
               + +      ++ AE+E  +RRR E+QAA
Sbjct: 1882 ALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1912



 Score = 37.4 bits (85), Expect = 0.060
 Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 25/194 (12%)

Query: 66   EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 122
            E++K ++EA+LL+  +  +   + E L   +     +             ++ Q   K E
Sbjct: 2485 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2544

Query: 123  ERDLVDRLKAEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETG 181
            +    +  KA+Q R +Q R+++ Q  Q R +L  + +  R+ + E E  +R  +E     
Sbjct: 2545 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2598

Query: 182  PEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSR-THSQLA 240
             E ++LEQ    +EEL+  E +         R+ E    LEE+H   + +    T SQ+A
Sbjct: 2599 -ELQQLEQQRRQQEELLAEENQ---------RLREQLQLLEEQHRAALAHSEEVTASQVA 2648

Query: 241  QFVHEVKKSPFGKD 254
                  K  P G+D
Sbjct: 2649 ----ATKTLPNGRD 2658



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 62/292 (21%), Positives = 108/292 (36%), Gaps = 39/292 (13%)

Query: 62   LRDFEQKKREEEARLLETGTGPLHDEKDESLCLSS------SCEGAAGTPRPAG-EPAWV 114
            ++D  Q+KR+ E  L           +++   L +        E A    R A  E A  
Sbjct: 1530 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1589

Query: 115  TQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKY-AAKRLRQEEEER-ENLLR 172
             Q   +  +R     L   Q++R    E+  QL+  +Q ++ A  +LR+E E R +    
Sbjct: 1590 VQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE 1646

Query: 173  LSREMLETGPEAERLE-----------QLESGEEELVLAEYESDEEKKVASRVDEDEDDL 221
              R   E   E ER +           Q E   ++  LA+ E++++K+ A R        
Sbjct: 1647 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1706

Query: 222  EEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
            EE+ + +     +   +  Q      +     +  L+ L +       E  +     QL+
Sbjct: 1707 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA-------ETEQGEQQRQLL 1759

Query: 282  NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAE 333
             +    +QR         E     ++RQE +A       E   LL  +A AE
Sbjct: 1760 EEELARLQR---------EAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1802



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 75/391 (19%), Positives = 141/391 (36%), Gaps = 48/391 (12%)

Query: 59   LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 118
            L+ LR     + E +  L+E         ++E L L +S E AA     AG+        
Sbjct: 1922 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA-----AGKA------- 1969

Query: 119  QKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREML 178
                       L+ E  R +   E   + + + +L+ A +R    EEER       R   
Sbjct: 1970 ----------ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 2019

Query: 179  ETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQ 238
                E E   Q ++  EE+   + + +E +++  R +++               S    Q
Sbjct: 2020 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE---------------SARQLQ 2064

Query: 239  LAQFVHEVKKSPFGKDVRLVSLGSRQNL--CVNEDVKSLGSVQLINDRCVDMQRSRHEKK 296
            LAQ   + +     K          Q L   + ++   L  ++   +          E +
Sbjct: 2065 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2124

Query: 297  KGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSR 356
              AE E  + RRQ ++A     + E+    R +A A  + + +        RA     + 
Sbjct: 2125 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2184

Query: 357  LAIPAAQLVVLPYQMLLHAATRQAAGIR-----LQDQVVIIDEAHNLIDTITGMHSVEVS 411
                AA   +  ++       RQ A +      L+ Q+   D   NL+D    +  ++  
Sbjct: 2185 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAE 2242

Query: 412  GSQLCQAHSQLLQYVERYGKRLKAKNLMYLK 442
             ++  +  SQ+ +  E +  R++ + L  LK
Sbjct: 2243 ATEAARQRSQVEE--ELFSVRVQMEELSKLK 2271



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 24/97 (24%), Positives = 45/97 (46%), Gaps = 1/97 (1%)

Query: 121  KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET 180
            +EE  L ++ +AE+  R    E   + Q ++   +A  + + E E +E   R+  E++  
Sbjct: 1372 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1431

Query: 181  GPEA-ERLEQLESGEEELVLAEYESDEEKKVASRVDE 216
               A +  +Q  S +EEL      S+ E +  +R  E
Sbjct: 1432 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1468


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,168,791
Number of Sequences: 37866
Number of extensions: 1502077
Number of successful extensions: 14098
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 182
Number of HSP's successfully gapped in prelim test: 609
Number of HSP's that attempted gapping in prelim test: 8400
Number of HSP's gapped (non-prelim): 3394
length of query: 856
length of database: 18,247,518
effective HSP length: 111
effective length of query: 745
effective length of database: 14,044,392
effective search space: 10463072040
effective search space used: 10463072040
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press