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Search of human proteins with 17986270
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
(414 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] 840 0.0
gi|4503385 dopamine receptor D2 isoform long [Homo sapiens] 824 0.0
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 391 e-109
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 384 e-107
gi|32483397 dopamine receptor D4 [Homo sapiens] 243 2e-64
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] 229 3e-60
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 214 2e-55
gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens] 212 6e-55
gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens] 201 8e-52
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 201 1e-51
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 196 4e-50
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 192 4e-49
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 192 4e-49
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 191 1e-48
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 183 3e-46
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 178 9e-45
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 178 9e-45
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 178 9e-45
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 178 9e-45
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 177 1e-44
gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo s... 173 2e-43
gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap... 168 7e-42
gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens] 164 1e-40
gi|194018562 histamine receptor H3 [Homo sapiens] 150 2e-36
gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens] 150 3e-36
gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens] 150 3e-36
gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens] 150 3e-36
gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens] 150 3e-36
gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens] 150 3e-36
gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens] 150 3e-36
>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
Length = 414
Score = 840 bits (2169), Expect = 0.0
Identities = 414/414 (100%), Positives = 414/414 (100%)
Query: 1 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS 60
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
Sbjct: 1 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS 60
Query: 61 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA 120
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
Sbjct: 61 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA 120
Query: 121 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN 180
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
Sbjct: 121 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN 180
Query: 181 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL 240
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
Sbjct: 181 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL 240
Query: 241 KEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNG 300
KEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNG
Sbjct: 241 KEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNG 300
Query: 301 HAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPF 360
HAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPF
Sbjct: 301 HAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPF 360
Query: 361 FITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 414
FITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
Sbjct: 361 FITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 414
>gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]
Length = 443
Score = 824 bits (2129), Expect = 0.0
Identities = 414/443 (93%), Positives = 414/443 (93%), Gaps = 29/443 (6%)
Query: 1 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS 60
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
Sbjct: 1 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS 60
Query: 61 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA 120
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
Sbjct: 61 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA 120
Query: 121 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN 180
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
Sbjct: 121 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN 180
Query: 181 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL 240
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
Sbjct: 181 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL 240
Query: 241 K-----------------------------EAARRAQELEMEMLSSTSPPERTRYSPIPP 271
K EAARRAQELEMEMLSSTSPPERTRYSPIPP
Sbjct: 241 KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP 300
Query: 272 SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR 331
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
Sbjct: 301 SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR 360
Query: 332 RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA 391
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
Sbjct: 361 RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA 420
Query: 392 VNPIIYTTFNIEFRKAFLKILHC 414
VNPIIYTTFNIEFRKAFLKILHC
Sbjct: 421 VNPIIYTTFNIEFRKAFLKILHC 443
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 391 bits (1004), Expect = e-109
Identities = 221/399 (55%), Positives = 268/399 (67%), Gaps = 24/399 (6%)
Query: 23 NGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLL 82
N + RPH YYA LI IVFGN LVCMAV +E+ALQTTTNYL+VSLAVADLL
Sbjct: 19 NSTGASQARPHA-YYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLL 77
Query: 83 VATLVMPWVVYLEVV-GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPML 141
VATLVMPWVVYLEV G W FSRI CD+FVTLDVMMCTASILNLCAISIDRYTAV MP+
Sbjct: 78 VATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVH 137
Query: 142 Y--NTRYSSKRRVTVMISIVWVLSFTISCPLLFGLN-NADQNECIIANPAFVVYSSIVSF 198
Y T SS RRV +MI+ VWVL+F +SCPLLFG N D C I+NP FV+YSS+VSF
Sbjct: 138 YQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSF 197
Query: 199 YVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSS 257
Y+PF VT+LVY +IY+VL+ RRRKR+ T+++S+ P + + LE++ S
Sbjct: 198 YLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYS 257
Query: 258 TSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTM 317
+L + + + L T PK++ E++ +
Sbjct: 258 ICQDTALGGPGFQERGGELKREEKTRNSLSPT--------------IAPKLS--LEVRKL 301
Query: 318 PNGKTRTSLKTMSRRKLS-QQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIP 375
NG+ TSLK + +EKKATQM+AIVLG FI+CWLPFF+TH+LN HC C++
Sbjct: 302 SNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVS 361
Query: 376 PVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 414
P LYSA TWLGYVNSA+NP+IYTTFNIEFRKAFLKIL C
Sbjct: 362 PELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 384 bits (987), Expect = e-107
Identities = 223/407 (54%), Positives = 261/407 (64%), Gaps = 73/407 (17%)
Query: 23 NGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLL 82
N + RPH YYA LI IVFGN LVCMAV +E+ALQTTTNYL+VSLAVADLL
Sbjct: 19 NSTGASQARPHA-YYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLL 77
Query: 83 VATLVMPWVVYLEVV-GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPML 141
VATLVMPWVVYLEV G W FSRI CD+FVTLDVMMCTASILNLCAISIDRYTAV MP+
Sbjct: 78 VATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVH 137
Query: 142 Y--NTRYSSKRRVTVMISIVWVLSFTISCPLLFGLN-NADQNECIIANPAFVVYSSIVSF 198
Y T SS RRV +MI+ VWVL+F +SCPLLFG N D C I+NP FV+YSS+VSF
Sbjct: 138 YQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSF 197
Query: 199 YVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSS 257
Y+PF VT+LVY +IY+VL+ RRRKR+ T+++S+
Sbjct: 198 YLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQC-------------------------- 231
Query: 258 TSPPERTRYSPIPPSHHQLTL-PDPSHHGL--------HSTPDSPAKPEKNGHAKDHPKI 308
+ + P Q TL PDP+H L + P E+ G K
Sbjct: 232 ---------NSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREE-- 280
Query: 309 AKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNI 368
KTR SL + +EKKATQM+AIVLG FI+CWLPFF+TH+LN
Sbjct: 281 ------------KTRNSLMPL--------REKKATQMVAIVLGAFIVCWLPFFLTHVLNT 320
Query: 369 HCD-CNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 414
HC C++ P LYSA TWLGYVNSA+NP+IYTTFNIEFRKAFLKIL C
Sbjct: 321 HCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
>gi|32483397 dopamine receptor D4 [Homo sapiens]
Length = 419
Score = 243 bits (621), Expect = 2e-64
Identities = 157/387 (40%), Positives = 213/387 (55%), Gaps = 31/387 (8%)
Query: 43 LLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVG-EWK 101
LLI ++ GN LVC++V+ E+ALQT TN IVSLA ADLL+A LV+P VY EV G W
Sbjct: 43 LLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWL 102
Query: 102 FSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWV 161
S CD + +DVM+CTASI NLCAIS+DR+ AVA+P+ YN R RR ++I W+
Sbjct: 103 LSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYN-RQGGSRRQLLLIGATWL 161
Query: 162 LSFTISCPLLFGLNNA---DQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRR 218
LS ++ P+L GLN+ D C + + +VVYSS+ SF++P + LL+Y + L+R
Sbjct: 162 LSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQR 221
Query: 219 ----RRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSP-----PERTRYSPI 269
RR +++ + R +P A R Q+ + +P P +P
Sbjct: 222 WEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPA 281
Query: 270 PPSHHQLTLPDPSHHGLHSTPDSPAKPEK---NGHAKDHPKIAKIFEIQTMPNGKTRTSL 326
PS Q DP G P +P P + A A QT P + R
Sbjct: 282 APSLPQ----DPC--GPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRA 335
Query: 327 KTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIPPVLYSAFTWL 385
K R E+KA ++L +V+G F++CW PFF+ HI C C++PP L SA TWL
Sbjct: 336 KITGR-------ERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWL 388
Query: 386 GYVNSAVNPIIYTTFNIEFRKAFLKIL 412
GYVNSA+NP+IYT FN EFR F K L
Sbjct: 389 GYVNSALNPVIYTVFNAEFRNVFRKAL 415
>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
Length = 465
Score = 229 bits (585), Expect = 3e-60
Identities = 142/412 (34%), Positives = 218/412 (52%), Gaps = 48/412 (11%)
Query: 40 LLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE 99
L LL+ + VFGNVLV +AV +AL+ N +VSLA AD+LVATLV+P+ + EV+G
Sbjct: 54 LAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY 113
Query: 100 WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIV 159
W F + C+I++ LDV+ CT+SI++LCAIS+DRY ++ + YN + + RR+ +I V
Sbjct: 114 WYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLK-RTPRRIKAIIITV 172
Query: 160 WVLSFTISCPLLFGLNNAD--------QNECIIANPAFVVYSSIV-SFYVPFIVTLLVYI 210
WV+S IS P L + + C I + + V SS + SF+ P ++ +LVY+
Sbjct: 173 WVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYV 232
Query: 211 KIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIP 270
+IY + +RR + ++R A + AP RR L E ++ P P+P
Sbjct: 233 RIYQIAKRRTRVPPSRRGPDA----VAAPPGGTERRPNGLGPE---RSAGPGGAEAEPLP 285
Query: 271 PSHH---------------QLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQ 315
+ L L + S P P +PE+ K + +++
Sbjct: 286 TQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGD 345
Query: 316 TMPN---------------GKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPF 360
++P G+ R SR + Q +EK+ T +LA+V+GVF++CW PF
Sbjct: 346 SLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPF 405
Query: 361 FITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 412
F T+ L C++P L+ F W GY NS++NP+IYT FN +FR+AF KIL
Sbjct: 406 FFTYTLTA-VGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL 456
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 214 bits (544), Expect = 2e-55
Identities = 125/392 (31%), Positives = 212/392 (54%), Gaps = 23/392 (5%)
Query: 37 YATLLTLLIAVIVF----GNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVV 92
Y + +LL+ ++F GN V A++ E++LQ NYLI SLAV DL+V+ LV+P
Sbjct: 35 YQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAA 94
Query: 93 YLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRV 152
+V+ +W ++ CD+F+ LDV+ CT+SIL+LCAI++DRY A+ P+ Y + + RR
Sbjct: 95 LYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNK-RTPRRA 153
Query: 153 TVMISIVWVLSFTISCPLLFGL----NNADQNECIIA-NPAFVVYSSIVSFYVPFIVTLL 207
+IS+ W++ F IS P + G + +D + C I+ + + +YS+ +FY+P ++ L+
Sbjct: 154 AALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLV 213
Query: 208 VYIKIYIVLR-RRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRY 266
+Y +I+ R R RK V + A H +P + + ++ S R
Sbjct: 214 LYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKK--------SVNGESGSRNWRL 265
Query: 267 SPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDH-PKIAKIFEIQTMPNGKTRTS 325
+ L G + + G++K+H P ++ P R +
Sbjct: 266 GVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKN 325
Query: 326 LKTM-SRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD--CNIPPVLYSAF 382
+ ++RK++ +E+K + L I++G FI+CWLPFFI ++ C+ C++P +L +
Sbjct: 326 ERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAII 385
Query: 383 TWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 414
WLGY NS +NP+IY FN +F+ AF KI+ C
Sbjct: 386 NWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKC 417
>gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]
Length = 450
Score = 212 bits (539), Expect = 6e-55
Identities = 136/429 (31%), Positives = 224/429 (52%), Gaps = 57/429 (13%)
Query: 38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV 97
A +T LI +FGN LV +AV ++L+ N +VSLA AD+LVATL++P+ + E++
Sbjct: 16 AAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELL 75
Query: 98 GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIS 157
G W F R C++++ LDV+ CT+SI++LCAIS+DRY AV+ + YN++ + RR+ +I
Sbjct: 76 GYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSK-RTPRRIKCIIL 134
Query: 158 IVWVLSFTISCPLLF-----GLNNADQNECIIANPA-FVVYSSIVSFYVPFIVTLLVYIK 211
VW+++ IS P L G + +C + A +++ SSI SF+ P ++ +LVY++
Sbjct: 135 TVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLR 194
Query: 212 IYIVLRRRRKR-------------VNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSS- 257
IY++ +R +R + A + P + A+E+ S+
Sbjct: 195 IYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTG 254
Query: 258 ----TSPPERTRYSPIPPSHHQLTLPDPSH---HGL-HSTPDSPAKPEKNGHAKDH---- 305
PE T +PPS LP+ G+ ++P+ A+ E+ ++
Sbjct: 255 EKEEGETPEDTGTRALPPS--WAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEP 312
Query: 306 ------PKIAKIFEIQTMPNGKTRTSLKTMS--------------RRKLSQQKEKKATQM 345
P A +Q + +L+ RR+ +EK+ T +
Sbjct: 313 QAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFV 372
Query: 346 LAIVLGVFIICWLPFFITHILNIHC--DCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIE 403
LA+V+GVF++CW PFF ++ L C C +P L+ F W+GY NS++NP+IYT FN +
Sbjct: 373 LAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQD 432
Query: 404 FRKAFLKIL 412
FR+AF +IL
Sbjct: 433 FRRAFRRIL 441
>gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]
Length = 462
Score = 201 bits (512), Expect = 8e-52
Identities = 139/409 (33%), Positives = 216/409 (52%), Gaps = 45/409 (11%)
Query: 38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV 97
A ++ LI V GNVLV +AV +AL+ N +VSLA AD+LVATLVMP+ + E++
Sbjct: 55 AAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELM 114
Query: 98 GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIS 157
W F ++ C +++ LDV+ CT+SI++LCAIS+DRY +V + YN + + RRV I
Sbjct: 115 AYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLK-RTPRRVKATIV 173
Query: 158 IVWVLSFTISCPLLFGL----NNADQNECIIANPAFVVYSSIV-SFYVPFIVTLLVYIKI 212
VW++S IS P L L + A +C + + + + SS + SF+ P ++ LVY +I
Sbjct: 174 AVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARI 233
Query: 213 YIVLRRRRKRVNTKRSSRAFRAHLRAPLKE----AARRAQE--------LEMEMLSSTSP 260
Y V + R + ++ KR+ +P E AA A E ++E S++
Sbjct: 234 YRVAKLRTRTLSEKRA--PVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAA 291
Query: 261 PERTR---------------YSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDH 305
ER R + Q P + G + SP + A
Sbjct: 292 AERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRAS-- 349
Query: 306 PKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHI 365
++ E + R+S + RRK++Q +EK+ T +LA+V+GVF++CW PFF ++
Sbjct: 350 ---SRSVEFFLSRRRRARSS---VCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYS 403
Query: 366 LNIHC--DCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 412
L C C +P L+ F W+GY NS++NP+IYT FN +FR++F IL
Sbjct: 404 LYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHIL 452
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 201 bits (511), Expect = 1e-51
Identities = 127/380 (33%), Positives = 192/380 (50%), Gaps = 70/380 (18%)
Query: 40 LLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE 99
+L I + GN+LV ++V+ + L+T TNY IV+LA+ADLL++ V+P+ LEV+G
Sbjct: 51 VLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGY 110
Query: 100 WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIV 159
W RI CDI+ +DV+ CTASIL+LCAISIDRY V + Y T + ++ + ++S V
Sbjct: 111 WVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLS-V 169
Query: 160 WVLSFTISCPLLFGLNNA---DQNEC-IIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIV 215
WVLS IS L G D EC + P + ++SS+ SFY+P V L++Y ++YIV
Sbjct: 170 WVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIV 229
Query: 216 LRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQ 275
+R K +L A + + ++EL + +
Sbjct: 230 AKRTTK-------------NLEAGVMKEMSNSKELTLRI--------------------- 255
Query: 276 LTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLS 335
H + D+ + + GH K+F+
Sbjct: 256 --------HSKNFHEDTLSSTKAKGHNPRSSIAVKLFKF--------------------- 286
Query: 336 QQKEKKATQMLAIVLGVFIICWLPFFITHIL-NIHCDCNIPPVLYSAFTWLGYVNSAVNP 394
+EKKA + L IV+G+FI+CWLPFFI L ++ P ++ WLGY NS +NP
Sbjct: 287 -SREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNP 345
Query: 395 IIYTTFNIEFRKAFLKILHC 414
IIY + EF++AF++IL C
Sbjct: 346 IIYPCSSKEFKRAFVRILGC 365
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 196 bits (497), Expect = 4e-50
Identities = 126/381 (33%), Positives = 189/381 (49%), Gaps = 59/381 (15%)
Query: 40 LLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE 99
LL L+ N V V R + L T NYLI SLAV DLLV+ LVMP V G
Sbjct: 55 LLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGR 114
Query: 100 WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIV 159
W ++ CD +++ D+ CTASIL+LC I++DRY A+ + Y+ + + K R VMI++V
Sbjct: 115 WTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPK-RAAVMIALV 173
Query: 160 WVLSFTISCPLLF---GLNNADQNECIIANP--AFVVYSSIVSFYVPFIVTLLVYIKIYI 214
WV S +IS P F + +EC++ + VYS++ +FY P ++ + +Y +IY+
Sbjct: 174 WVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYV 233
Query: 215 VLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIPPSHH 274
R R + R+ + L L + SP + + I
Sbjct: 234 EARSRILKQTPNRTGK------------------RLTRAQLITDSPGSTSSVTSI----- 270
Query: 275 QLTLPD-PSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRK 333
+PD PS G + ++ Q K R S + ++K
Sbjct: 271 NSRVPDVPSESG-----------------------SPVYVNQV----KVRVSDALLEKKK 303
Query: 334 LSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD--CNIPPVLYSAFTWLGYVNSA 391
L +E+KAT+ L I+LG FI+CWLPFFI ++ C C ++ FTWLGY+NS
Sbjct: 304 LMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSL 363
Query: 392 VNPIIYTTFNIEFRKAFLKIL 412
+NPIIYT N +F++AF K++
Sbjct: 364 INPIIYTMSNEDFKQAFHKLI 384
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 192 bits (489), Expect = 4e-49
Identities = 127/382 (33%), Positives = 185/382 (48%), Gaps = 59/382 (15%)
Query: 38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV 97
A +L+++ V N V + + L T NYLI SLA DLLV+ LVMP + +
Sbjct: 42 AVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTIT 101
Query: 98 GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIS 157
W F +I CDI+++ D+ CTASIL+LC I++DRY A+ + Y+ R ++ T MI+
Sbjct: 102 HTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAT-MIA 160
Query: 158 IVWVLSFTISCPLLFGLNNADQNE---CII--ANPAFVVYSSIVSFYVPFIVTLLVYIKI 212
IVW +S IS P LF Q E C++ + ++ +YS+ +FY+P ++ +++Y +I
Sbjct: 161 IVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRI 220
Query: 213 YIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIPPS 272
Y R R + R AHL +
Sbjct: 221 YRAARNRILNPPSLYGKRFTTAHLIT-------------------------------GSA 249
Query: 273 HHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRR 332
L + S H HS H+ P +I+ + R + R
Sbjct: 250 GSSLCSLNSSLHEGHS------------HSAGSPLFFNHVKIKLADSALERKRISAARER 297
Query: 333 KLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHC--DCNIPPVLYSAFTWLGYVNS 390
K AT++L I+LG FIICWLPFF+ ++ C C I P L+ FTWLGY+NS
Sbjct: 298 K--------ATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNS 349
Query: 391 AVNPIIYTTFNIEFRKAFLKIL 412
+NPIIYT FN EFR+AF KI+
Sbjct: 350 LINPIIYTVFNEEFRQAFQKIV 371
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 192 bits (489), Expect = 4e-49
Identities = 126/379 (33%), Positives = 195/379 (51%), Gaps = 67/379 (17%)
Query: 41 LTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEW 100
L I + V GN+LV ++V+ + LQT TNY IV+LAVADLL++ V+P+ +EV+G W
Sbjct: 103 LAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFW 162
Query: 101 KFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVW 160
F R CD++ +DV+ CTASIL+LC IS+DRY V + Y ++R+ +++++W
Sbjct: 163 AFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKY-PAIMTERKAAAILALLW 221
Query: 161 VLSFTISCPLLFGLNN---ADQNECIIANPA-FVVYSSIVSFYVPFIVTLLVYIKIYIVL 216
V++ +S L G D+ C I A + V+SS+ SFY+P V +++Y ++Y+V
Sbjct: 222 VVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVA 281
Query: 217 RRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQL 276
R +T RS L A +K +A E+ + +
Sbjct: 282 R------STTRS-------LEAGVKRERGKASEVVLRI----------------HCRGAA 312
Query: 277 TLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQ 336
T D + HG+ S AK H T ++S R L
Sbjct: 313 TGADGA-HGMRS-------------AKGH------------------TFRSSLSVRLLKF 340
Query: 337 QKEKKATQMLAIVLGVFIICWLP-FFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPI 395
+EKKA + LAIV+GVF++CW P FF+ + ++ ++ WLGY NS VNP+
Sbjct: 341 SREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPL 400
Query: 396 IYTTFNIEFRKAFLKILHC 414
IY + EF++AFL++L C
Sbjct: 401 IYPCSSREFKRAFLRLLRC 419
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 191 bits (485), Expect = 1e-48
Identities = 125/369 (33%), Positives = 189/369 (51%), Gaps = 51/369 (13%)
Query: 52 NVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFV 111
N LV A+ + L NYLI SLAV D LVA LVMP+ + V W ++ CDI++
Sbjct: 41 NSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWL 100
Query: 112 TLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLL 171
++D+ CT SIL+L AI++DRY A+ + Y R + + +MI+IVW++S IS P L
Sbjct: 101 SVDITCCTCSILHLSAIALDRYRAITDAVEY-ARKRTPKHAGIMITIVWIISVFISMPPL 159
Query: 172 FGLN--NADQNECIIANPAFV--VYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKR 227
F + + +ECII + V +YS+ +FY+P + L++Y KIY R K + KR
Sbjct: 160 FWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIY----RAAKTLYHKR 215
Query: 228 SSRAFRAHLRAPLKEAARRA-QELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGL 286
+A+R A +E+ ++L + S L+ P +
Sbjct: 216 --------------QASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKI 261
Query: 287 HSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQML 346
HST S K+ K+ R+K+S +E+KA L
Sbjct: 262 HSTVRSLRSEFKHE--------------------------KSWRRQKISGTRERKAATTL 295
Query: 347 AIVLGVFIICWLPFFITHILNIHCD-CNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFR 405
++LG F+ICWLPFF+ ++ CD C I + + WLGY+NS +NP+IYT FN +F+
Sbjct: 296 GLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFK 355
Query: 406 KAFLKILHC 414
KAF K++ C
Sbjct: 356 KAFQKLVRC 364
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 183 bits (464), Expect = 3e-46
Identities = 119/387 (30%), Positives = 189/387 (48%), Gaps = 69/387 (17%)
Query: 40 LLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE 99
L+ L++ +IV GNVLV +A+++ LQT TN I+SLA ADL++ LV+P+ + V G
Sbjct: 64 LMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGR 123
Query: 100 WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIV 159
W++ C+++ ++DV+ TASI LC I++DRY A+ P Y + + + R ++ V
Sbjct: 124 WEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLT-RARARGLVCTV 182
Query: 160 WVLSFTIS-CPLLFGLNNADQNEC-----------IIANPAFVVYSSIVSFYVPFIVTLL 207
W +S +S P+L A+ +E + N A+ + SS+VSFYVP +
Sbjct: 183 WAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAF 242
Query: 208 VYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYS 267
VY++++ +++ K++++ E L + P S
Sbjct: 243 VYLRVFREAQKQVKKIDS------------------------CERRFLGGPARPPSPSPS 278
Query: 268 PIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLK 327
P+P P P + P NG A GK R S
Sbjct: 279 PVPA-------PAPPPGPPRPAAAAATAPLANGRA-----------------GKRRPS-- 312
Query: 328 TMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGY 387
+L +E+KA + L I++GVF +CWLPFF+ +++ +P L+ F WLGY
Sbjct: 313 -----RLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGY 367
Query: 388 VNSAVNPIIYTTFNIEFRKAFLKILHC 414
NSA NPIIY + +FRKAF +L C
Sbjct: 368 ANSAFNPIIYCR-SPDFRKAFQGLLCC 393
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 178 bits (451), Expect = 9e-45
Identities = 119/374 (31%), Positives = 185/374 (49%), Gaps = 73/374 (19%)
Query: 44 LIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFS 103
LI V GN+LV ++V+ + L + T+Y IV+LAVADLL+ + V+P+ EV+G W F
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95
Query: 104 RIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLS 163
R+ C+I+ +DV+ CTASI+ LC ISIDRY V+ P+ Y T + +R + ++ VW LS
Sbjct: 96 RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALL-CVWALS 154
Query: 164 FTISCPLLFGLNN---ADQNEC-IIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRR 219
IS LFG D+ C I P +V++S++ SFY+P + L++Y ++Y+V
Sbjct: 155 LVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVV---- 210
Query: 220 RKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLP 279
KR SR ++ L+ ++ Q+TL
Sbjct: 211 -----AKRESRGLKSGLKTDKSDS------------------------------EQVTL- 234
Query: 280 DPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKE 339
+H ++PA G K F ++ + + + + KT
Sbjct: 235 -----RIH-RKNAPA----GGSGMASAKTKTHFSVRLLKFSREKKAAKT----------- 273
Query: 340 KKATQMLAIVLGVFIICWLPFF-ITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYT 398
L IV+G F++CWLPFF + I + D ++ WLGY+NS +NPIIY
Sbjct: 274 ------LGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYP 327
Query: 399 TFNIEFRKAFLKIL 412
+ EF+KAF +L
Sbjct: 328 CSSQEFKKAFQNVL 341
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 178 bits (451), Expect = 9e-45
Identities = 119/374 (31%), Positives = 185/374 (49%), Gaps = 73/374 (19%)
Query: 44 LIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFS 103
LI V GN+LV ++V+ + L + T+Y IV+LAVADLL+ + V+P+ EV+G W F
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95
Query: 104 RIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLS 163
R+ C+I+ +DV+ CTASI+ LC ISIDRY V+ P+ Y T + +R + ++ VW LS
Sbjct: 96 RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALL-CVWALS 154
Query: 164 FTISCPLLFGLNN---ADQNEC-IIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRR 219
IS LFG D+ C I P +V++S++ SFY+P + L++Y ++Y+V
Sbjct: 155 LVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVV---- 210
Query: 220 RKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLP 279
KR SR ++ L+ ++ Q+TL
Sbjct: 211 -----AKRESRGLKSGLKTDKSDS------------------------------EQVTL- 234
Query: 280 DPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKE 339
+H ++PA G K F ++ + + + + KT
Sbjct: 235 -----RIH-RKNAPA----GGSGMASAKTKTHFSVRLLKFSREKKAAKT----------- 273
Query: 340 KKATQMLAIVLGVFIICWLPFF-ITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYT 398
L IV+G F++CWLPFF + I + D ++ WLGY+NS +NPIIY
Sbjct: 274 ------LGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYP 327
Query: 399 TFNIEFRKAFLKIL 412
+ EF+KAF +L
Sbjct: 328 CSSQEFKKAFQNVL 341
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 178 bits (451), Expect = 9e-45
Identities = 119/374 (31%), Positives = 185/374 (49%), Gaps = 73/374 (19%)
Query: 44 LIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFS 103
LI V GN+LV ++V+ + L + T+Y IV+LAVADLL+ + V+P+ EV+G W F
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95
Query: 104 RIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLS 163
R+ C+I+ +DV+ CTASI+ LC ISIDRY V+ P+ Y T + +R + ++ VW LS
Sbjct: 96 RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALL-CVWALS 154
Query: 164 FTISCPLLFGLNN---ADQNEC-IIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRR 219
IS LFG D+ C I P +V++S++ SFY+P + L++Y ++Y+V
Sbjct: 155 LVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVV---- 210
Query: 220 RKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLP 279
KR SR ++ L+ ++ Q+TL
Sbjct: 211 -----AKRESRGLKSGLKTDKSDS------------------------------EQVTL- 234
Query: 280 DPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKE 339
+H ++PA G K F ++ + + + + KT
Sbjct: 235 -----RIH-RKNAPA----GGSGMASAKTKTHFSVRLLKFSREKKAAKT----------- 273
Query: 340 KKATQMLAIVLGVFIICWLPFF-ITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYT 398
L IV+G F++CWLPFF + I + D ++ WLGY+NS +NPIIY
Sbjct: 274 ------LGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYP 327
Query: 399 TFNIEFRKAFLKIL 412
+ EF+KAF +L
Sbjct: 328 CSSQEFKKAFQNVL 341
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 178 bits (451), Expect = 9e-45
Identities = 119/374 (31%), Positives = 185/374 (49%), Gaps = 73/374 (19%)
Query: 44 LIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFS 103
LI V GN+LV ++V+ + L + T+Y IV+LAVADLL+ + V+P+ EV+G W F
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95
Query: 104 RIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLS 163
R+ C+I+ +DV+ CTASI+ LC ISIDRY V+ P+ Y T + +R + ++ VW LS
Sbjct: 96 RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALL-CVWALS 154
Query: 164 FTISCPLLFGLNN---ADQNEC-IIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRR 219
IS LFG D+ C I P +V++S++ SFY+P + L++Y ++Y+V
Sbjct: 155 LVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVV---- 210
Query: 220 RKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLP 279
KR SR ++ L+ ++ Q+TL
Sbjct: 211 -----AKRESRGLKSGLKTDKSDS------------------------------EQVTL- 234
Query: 280 DPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKE 339
+H ++PA G K F ++ + + + + KT
Sbjct: 235 -----RIH-RKNAPA----GGSGMASAKTKTHFSVRLLKFSREKKAAKT----------- 273
Query: 340 KKATQMLAIVLGVFIICWLPFF-ITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYT 398
L IV+G F++CWLPFF + I + D ++ WLGY+NS +NPIIY
Sbjct: 274 ------LGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYP 327
Query: 399 TFNIEFRKAFLKIL 412
+ EF+KAF +L
Sbjct: 328 CSSQEFKKAFQNVL 341
>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
Length = 365
Score = 177 bits (450), Expect = 1e-44
Identities = 118/382 (30%), Positives = 188/382 (49%), Gaps = 60/382 (15%)
Query: 39 TLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVG 98
TL TLL N+ V MA+ K L NYLI SLAV DLLVA LVMP + V+
Sbjct: 34 TLTTLL-------NLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMD 86
Query: 99 EWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISI 158
WK C++++++D+ CT SIL+LC I++DRY A+ + Y R + +R +MI
Sbjct: 87 RWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEY-ARKRTAKRAALMILT 145
Query: 159 VWVLSFTISCPLLFGLN----NADQNECIIANP--AFVVYSSIVSFYVPFIVTLLVYIKI 212
VW +S IS P LF + + ++C I + + +YS++ +FY+P + L++Y +I
Sbjct: 146 VWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRI 205
Query: 213 YIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIPPS 272
Y K + KR S ++ + + + + +S S + T +
Sbjct: 206 Y----HAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPT--TEFEKF 259
Query: 273 HHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRR 332
H + +P P + L DHP R+
Sbjct: 260 HASIRIP-PFDNDL-----------------DHPG----------------------ERQ 279
Query: 333 KLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAV 392
++S +E+KA ++L ++LG FI+ WLPFFI ++ + + TWLGYVNS +
Sbjct: 280 QISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLI 339
Query: 393 NPIIYTTFNIEFRKAFLKILHC 414
NP++YT+FN +F+ AF K++ C
Sbjct: 340 NPLLYTSFNEDFKLAFKKLIRC 361
>gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo
sapiens]
Length = 481
Score = 173 bits (439), Expect = 2e-43
Identities = 120/397 (30%), Positives = 200/397 (50%), Gaps = 72/397 (18%)
Query: 36 YYATLLTLLIAV-IVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYL 94
++A LL L++ + + GN LV +AVS EK LQ TNY ++SLAVADLLV VMP + L
Sbjct: 55 HWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMP-IALL 113
Query: 95 EVVGE--WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRV 152
++ E W + C ++ LDV+ TASI++LCAIS+DRY A+ P+ N +Y+S+
Sbjct: 114 TIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQAN-QYNSRATA 172
Query: 153 TVMISIVWVLSFTISCPLLF-----GLNNADQNECIIANPA---FVVYSSIVSFYVPFIV 204
+ I++VW++S I+ P+ ++N + C++ F+++ S+ +F+ P +
Sbjct: 173 FIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAI 232
Query: 205 TLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERT 264
++ Y L+++ V K PP+R
Sbjct: 233 MIVTYFLTIHALQKKAYLVKNK---------------------------------PPQRL 259
Query: 265 RYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRT 324
+ + + P S+P+ A +G KD + +PN T
Sbjct: 260 TWLTVSTVFQRDETP-------CSSPEKVAM--LDGSRKD----------KALPNSGDET 300
Query: 325 SLK---TMSRRKLSQ-QKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD-CN--IPPV 377
++ T+ ++ + E++A+++L IV +F++ W PFFIT+I + CD CN +
Sbjct: 301 LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM 360
Query: 378 LYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 414
L F W+GYV+S VNP++YT FN FR AF + + C
Sbjct: 361 LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 397
>gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
sapiens]
Length = 458
Score = 168 bits (426), Expect = 7e-42
Identities = 121/403 (30%), Positives = 198/403 (49%), Gaps = 65/403 (16%)
Query: 22 FNGSDG---KADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAV 78
FN SDG K N+ A + ++I + + GN+LV MAVS EK L TNY ++SLA+
Sbjct: 38 FNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAI 97
Query: 79 ADLLVATLVMPWVVYLEVVGE--WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAV 136
AD+LV LVMP + L ++ + W R C ++++LDV+ TASI++LCAIS+DRY A+
Sbjct: 98 ADMLVGLLVMP-LSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAI 156
Query: 137 AMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPL-LFGLNNADQNECIIANPAFVVYSSI 195
P + ++R++S+ + + I+IVW +S +S P+ + GL + ++ + N V +
Sbjct: 157 RNP-IEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEK---VFVNNTTCVLNDP 212
Query: 196 VSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEML 255
+ V + + I ++ V +++ H P L ++ L
Sbjct: 213 NFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEP--------PGLSLDFL 264
Query: 256 SSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQ 315
+ ++ A P ++ +A+ K
Sbjct: 265 KCCKRNT-------------------------AEEENSANPNQDQNARRRKK-------- 291
Query: 316 TMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD--CN 373
K R TM + E+KA+++L IV VF+I W PFFIT+IL++ C+ CN
Sbjct: 292 -----KERRPRGTMQ----AINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCN 342
Query: 374 --IPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 414
+ L + F W+GYV S +NP++YT FN +R+AF L C
Sbjct: 343 QKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRC 385
>gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]
Length = 479
Score = 164 bits (416), Expect = 1e-40
Identities = 125/474 (26%), Positives = 199/474 (41%), Gaps = 89/474 (18%)
Query: 21 PFNGSDGKAD-----RPHYNYYATLLTLLIAVI--------VFGNVLVCMAVSREKALQT 67
P NGS G +N Y T+ + IA + V GN+LV +++ + LQT
Sbjct: 6 PVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQT 65
Query: 68 TTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCA 127
NY + SLA ADL++ M + G W + CD+++ LD ++ AS++NL
Sbjct: 66 VNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLI 125
Query: 128 ISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLF------GLNNADQNE 181
IS DRY V P+ Y R ++K +MI+ WVLSF + P + G N+
Sbjct: 126 ISFDRYFCVTKPLTYPARRTTK-MAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQ 184
Query: 182 CII---ANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRR---RKRVNTKRSSRAFRAH 235
C I +NPA ++I +FY+P ++ ++YI I + R R + K A
Sbjct: 185 CFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAF 244
Query: 236 LRAPLK----------EAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHG 285
L++PL EAAR +EL L PP +PP + D S+
Sbjct: 245 LKSPLMKQSVKKPPPGEAAR--EELRNGKLEEAPPP------ALPPPPRPVADKDTSNES 296
Query: 286 LH--------------------STPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTS 325
+TP PA P + + +KI + + T+
Sbjct: 297 SSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTA 356
Query: 326 LK-------------------------TMSRRKLSQQKEKKATQMLAIVLGVFIICWLPF 360
++ + +++ +E+K T+ + +L FI+ W P+
Sbjct: 357 IEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPY 416
Query: 361 FITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 414
+ ++N C IP ++S WL YVNS +NP Y N F+K F +L C
Sbjct: 417 NVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLC 470
>gi|194018562 histamine receptor H3 [Homo sapiens]
Length = 445
Score = 150 bits (379), Expect = 2e-36
Identities = 104/409 (25%), Positives = 185/409 (45%), Gaps = 53/409 (12%)
Query: 38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV 97
A L+ LLI V GN LV +A + +L+T N+ +++LA++D LV +P V +
Sbjct: 38 AALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLT 97
Query: 98 GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIS 157
G W F R C +++ +D ++CT+S N+ IS DR+ +V + Y + RR +
Sbjct: 98 GRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKML 157
Query: 158 IVWVLSFTISCPLLF------GLNNADQNEC---IIANPAFVVYSSIVSFYVPFIVTLLV 208
+VWVL+F + P + G ++ + C N F++ +S + F+ PF+
Sbjct: 158 LVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFF 217
Query: 209 YIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPE------ 262
+ IY+ ++RR + LR + AR A E + SPP
Sbjct: 218 NLSIYLNIQRRTR--------------LRL---DGAREAAGPEPPPEAQPSPPPPPGCWG 260
Query: 263 --RTRYSPIPPSHH-------------QLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPK 307
+ + P H + TL G ++P S + G + P+
Sbjct: 261 CWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRG--TERPR 318
Query: 308 IAKIFEIQTMPNGKTRTSLKTMSR---RKLSQQKEKKATQMLAIVLGVFIICWLPFFITH 364
K + + +K +S+ ++ +++K + LA+++ +F +CW P+ +
Sbjct: 319 SLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLM 378
Query: 365 ILNIHCDCN-IPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 412
I+ C + +P Y WL + NSAVNP++Y + FR+AF K+L
Sbjct: 379 IIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
>gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 150 bits (378), Expect = 3e-36
Identities = 112/444 (25%), Positives = 186/444 (41%), Gaps = 67/444 (15%)
Query: 34 YNYYATLLTLLIA-----VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVM 88
Y + + +L+A V + GN+LV +++ + LQT NY + SLA ADL++ M
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 89 PWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSS 148
V+G W + CD+++ LD ++ AS++NL IS DRY V P+ Y + ++
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 149 KRRVTVMISIVWVLSFTISCP------LLFGLNNADQNECII---ANPAFVVYSSIVSFY 199
K +MI+ WVLSF + P + G+ + EC I +N A ++I +FY
Sbjct: 138 K-MAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 200 VPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTS 259
+P I+ ++Y + + R + R+ + +P R + M SS
Sbjct: 197 LPVIIMTVLY---WHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDD 253
Query: 260 PPERTRY----SPIPPSHHQLTLPDPSHHGLHSTP---------DSPAKPEKN------G 300
E + +P P + ST D ++N G
Sbjct: 254 GLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLG 313
Query: 301 HAKDHPKIAKIFEIQTM---------------------PNGKTRTSL---------KTMS 330
H+KD I T NG + ++ K +
Sbjct: 314 HSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPA 373
Query: 331 RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS 390
++K +EKK T+ + +L FII W P+ + ++N C IP +++ WL Y+NS
Sbjct: 374 KKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINS 433
Query: 391 AVNPIIYTTFNIEFRKAFLKILHC 414
+NP Y N F+K F +L C
Sbjct: 434 TINPACYALCNATFKKTFKHLLMC 457
>gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 150 bits (378), Expect = 3e-36
Identities = 112/444 (25%), Positives = 186/444 (41%), Gaps = 67/444 (15%)
Query: 34 YNYYATLLTLLIA-----VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVM 88
Y + + +L+A V + GN+LV +++ + LQT NY + SLA ADL++ M
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 89 PWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSS 148
V+G W + CD+++ LD ++ AS++NL IS DRY V P+ Y + ++
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 149 KRRVTVMISIVWVLSFTISCP------LLFGLNNADQNECII---ANPAFVVYSSIVSFY 199
K +MI+ WVLSF + P + G+ + EC I +N A ++I +FY
Sbjct: 138 K-MAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 200 VPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTS 259
+P I+ ++Y + + R + R+ + +P R + M SS
Sbjct: 197 LPVIIMTVLY---WHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDD 253
Query: 260 PPERTRY----SPIPPSHHQLTLPDPSHHGLHSTP---------DSPAKPEKN------G 300
E + +P P + ST D ++N G
Sbjct: 254 GLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLG 313
Query: 301 HAKDHPKIAKIFEIQTM---------------------PNGKTRTSL---------KTMS 330
H+KD I T NG + ++ K +
Sbjct: 314 HSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPA 373
Query: 331 RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS 390
++K +EKK T+ + +L FII W P+ + ++N C IP +++ WL Y+NS
Sbjct: 374 KKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINS 433
Query: 391 AVNPIIYTTFNIEFRKAFLKILHC 414
+NP Y N F+K F +L C
Sbjct: 434 TINPACYALCNATFKKTFKHLLMC 457
>gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 150 bits (378), Expect = 3e-36
Identities = 112/444 (25%), Positives = 186/444 (41%), Gaps = 67/444 (15%)
Query: 34 YNYYATLLTLLIA-----VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVM 88
Y + + +L+A V + GN+LV +++ + LQT NY + SLA ADL++ M
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 89 PWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSS 148
V+G W + CD+++ LD ++ AS++NL IS DRY V P+ Y + ++
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 149 KRRVTVMISIVWVLSFTISCP------LLFGLNNADQNECII---ANPAFVVYSSIVSFY 199
K +MI+ WVLSF + P + G+ + EC I +N A ++I +FY
Sbjct: 138 K-MAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 200 VPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTS 259
+P I+ ++Y + + R + R+ + +P R + M SS
Sbjct: 197 LPVIIMTVLY---WHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDD 253
Query: 260 PPERTRY----SPIPPSHHQLTLPDPSHHGLHSTP---------DSPAKPEKN------G 300
E + +P P + ST D ++N G
Sbjct: 254 GLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLG 313
Query: 301 HAKDHPKIAKIFEIQTM---------------------PNGKTRTSL---------KTMS 330
H+KD I T NG + ++ K +
Sbjct: 314 HSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPA 373
Query: 331 RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS 390
++K +EKK T+ + +L FII W P+ + ++N C IP +++ WL Y+NS
Sbjct: 374 KKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINS 433
Query: 391 AVNPIIYTTFNIEFRKAFLKILHC 414
+NP Y N F+K F +L C
Sbjct: 434 TINPACYALCNATFKKTFKHLLMC 457
>gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 150 bits (378), Expect = 3e-36
Identities = 112/444 (25%), Positives = 186/444 (41%), Gaps = 67/444 (15%)
Query: 34 YNYYATLLTLLIA-----VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVM 88
Y + + +L+A V + GN+LV +++ + LQT NY + SLA ADL++ M
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 89 PWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSS 148
V+G W + CD+++ LD ++ AS++NL IS DRY V P+ Y + ++
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 149 KRRVTVMISIVWVLSFTISCP------LLFGLNNADQNECII---ANPAFVVYSSIVSFY 199
K +MI+ WVLSF + P + G+ + EC I +N A ++I +FY
Sbjct: 138 K-MAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 200 VPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTS 259
+P I+ ++Y + + R + R+ + +P R + M SS
Sbjct: 197 LPVIIMTVLY---WHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDD 253
Query: 260 PPERTRY----SPIPPSHHQLTLPDPSHHGLHSTP---------DSPAKPEKN------G 300
E + +P P + ST D ++N G
Sbjct: 254 GLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLG 313
Query: 301 HAKDHPKIAKIFEIQTM---------------------PNGKTRTSL---------KTMS 330
H+KD I T NG + ++ K +
Sbjct: 314 HSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPA 373
Query: 331 RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS 390
++K +EKK T+ + +L FII W P+ + ++N C IP +++ WL Y+NS
Sbjct: 374 KKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINS 433
Query: 391 AVNPIIYTTFNIEFRKAFLKILHC 414
+NP Y N F+K F +L C
Sbjct: 434 TINPACYALCNATFKKTFKHLLMC 457
>gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 150 bits (378), Expect = 3e-36
Identities = 112/444 (25%), Positives = 186/444 (41%), Gaps = 67/444 (15%)
Query: 34 YNYYATLLTLLIA-----VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVM 88
Y + + +L+A V + GN+LV +++ + LQT NY + SLA ADL++ M
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 89 PWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSS 148
V+G W + CD+++ LD ++ AS++NL IS DRY V P+ Y + ++
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 149 KRRVTVMISIVWVLSFTISCP------LLFGLNNADQNECII---ANPAFVVYSSIVSFY 199
K +MI+ WVLSF + P + G+ + EC I +N A ++I +FY
Sbjct: 138 K-MAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 200 VPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTS 259
+P I+ ++Y + + R + R+ + +P R + M SS
Sbjct: 197 LPVIIMTVLY---WHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDD 253
Query: 260 PPERTRY----SPIPPSHHQLTLPDPSHHGLHSTP---------DSPAKPEKN------G 300
E + +P P + ST D ++N G
Sbjct: 254 GLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLG 313
Query: 301 HAKDHPKIAKIFEIQTM---------------------PNGKTRTSL---------KTMS 330
H+KD I T NG + ++ K +
Sbjct: 314 HSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPA 373
Query: 331 RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS 390
++K +EKK T+ + +L FII W P+ + ++N C IP +++ WL Y+NS
Sbjct: 374 KKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINS 433
Query: 391 AVNPIIYTTFNIEFRKAFLKILHC 414
+NP Y N F+K F +L C
Sbjct: 434 TINPACYALCNATFKKTFKHLLMC 457
>gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 150 bits (378), Expect = 3e-36
Identities = 112/444 (25%), Positives = 186/444 (41%), Gaps = 67/444 (15%)
Query: 34 YNYYATLLTLLIA-----VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVM 88
Y + + +L+A V + GN+LV +++ + LQT NY + SLA ADL++ M
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 89 PWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSS 148
V+G W + CD+++ LD ++ AS++NL IS DRY V P+ Y + ++
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 149 KRRVTVMISIVWVLSFTISCP------LLFGLNNADQNECII---ANPAFVVYSSIVSFY 199
K +MI+ WVLSF + P + G+ + EC I +N A ++I +FY
Sbjct: 138 K-MAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 200 VPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTS 259
+P I+ ++Y + + R + R+ + +P R + M SS
Sbjct: 197 LPVIIMTVLY---WHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDD 253
Query: 260 PPERTRY----SPIPPSHHQLTLPDPSHHGLHSTP---------DSPAKPEKN------G 300
E + +P P + ST D ++N G
Sbjct: 254 GLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLG 313
Query: 301 HAKDHPKIAKIFEIQTM---------------------PNGKTRTSL---------KTMS 330
H+KD I T NG + ++ K +
Sbjct: 314 HSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPA 373
Query: 331 RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS 390
++K +EKK T+ + +L FII W P+ + ++N C IP +++ WL Y+NS
Sbjct: 374 KKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINS 433
Query: 391 AVNPIIYTTFNIEFRKAFLKILHC 414
+NP Y N F+K F +L C
Sbjct: 434 TINPACYALCNATFKKTFKHLLMC 457
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.137 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,180,868
Number of Sequences: 37866
Number of extensions: 665491
Number of successful extensions: 5069
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 414
Number of HSP's successfully gapped in prelim test: 282
Number of HSP's that attempted gapping in prelim test: 3495
Number of HSP's gapped (non-prelim): 1292
length of query: 414
length of database: 18,247,518
effective HSP length: 105
effective length of query: 309
effective length of database: 14,271,588
effective search space: 4409920692
effective search space used: 4409920692
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.