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Search of human proteins with 16933535
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide
43 isoform 3 [Homo sapiens]
(420 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ... 849 0.0
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 845 0.0
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 843 0.0
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 662 0.0
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 653 0.0
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 631 0.0
gi|195972900 thromboxane A synthase 1, platelet isoform TXS-II [... 239 3e-63
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H... 239 3e-63
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H... 239 3e-63
gi|30023836 cytochrome P450 4Z1 [Homo sapiens] 130 3e-30
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide... 127 2e-29
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide... 120 3e-27
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ... 119 7e-27
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide... 118 9e-27
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11... 117 1e-26
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11... 117 1e-26
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8... 117 2e-26
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide... 115 1e-25
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide... 111 1e-24
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ... 110 2e-24
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ... 109 4e-24
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ... 105 1e-22
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6... 102 5e-22
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1... 102 6e-22
gi|5729796 cytochrome P450, family 46 [Homo sapiens] 102 6e-22
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ... 102 8e-22
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide... 100 4e-21
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide... 99 7e-21
gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide ... 96 6e-20
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ... 95 1e-19
>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 3 [Homo sapiens]
Length = 420
Score = 849 bits (2194), Expect = 0.0
Identities = 420/420 (100%), Positives = 420/420 (100%)
Query: 1 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF
Sbjct: 1 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60
Query: 61 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120
DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF
Sbjct: 61 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120
Query: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180
AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT
Sbjct: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180
Query: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240
MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL
Sbjct: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240
Query: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300
FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI
Sbjct: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300
Query: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
Query: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERSH 420
NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERSH
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERSH 420
>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 2 [Homo sapiens]
Length = 503
Score = 845 bits (2182), Expect = 0.0
Identities = 418/418 (100%), Positives = 418/418 (100%)
Query: 1 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF
Sbjct: 1 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60
Query: 61 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120
DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF
Sbjct: 61 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120
Query: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180
AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT
Sbjct: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180
Query: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240
MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL
Sbjct: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240
Query: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300
FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI
Sbjct: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300
Query: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
Query: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 1 [Homo sapiens]
Length = 504
Score = 843 bits (2177), Expect = 0.0
Identities = 417/417 (100%), Positives = 417/417 (100%)
Query: 1 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF
Sbjct: 1 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60
Query: 61 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120
DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF
Sbjct: 61 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120
Query: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180
AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT
Sbjct: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180
Query: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240
MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL
Sbjct: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240
Query: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300
FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI
Sbjct: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300
Query: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
Query: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE 417
NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE 417
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 662 bits (1708), Expect = 0.0
Identities = 316/418 (75%), Positives = 365/418 (87%)
Query: 1 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60
M LIP+ AMETW+L+A SLVLLY+YGTHSH LFKKLGIPGPTPLPFLG IL Y +G F
Sbjct: 1 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF 60
Query: 61 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120
D EC++KYG++WG Y+GQQP+L I DPDMIKTVLVKECYSVFTN+ P GP+GF+KSA+S
Sbjct: 61 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 120
Query: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180
AEDEEWKR+R+LLSP FTS K KEMVPII+Q GD+LVR+LR+EAE K + LKD FGAY+
Sbjct: 121 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 180
Query: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240
MDVIT T FGVN+DSLNNPQDPF++N KKLL+ DFLDPF L I++FPFL P+ E LNI +
Sbjct: 181 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV 240
Query: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300
FP++VT+FL+ S++RMKESRL+D QKHRVDF Q MIDSQNSKET+SHKALSDLELVAQSI
Sbjct: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
Query: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
I IFA Y+TTS+ L FIMYELATHPDVQQKLQEEIDAVLPNKAP TYD ++QMEYLDMVV
Sbjct: 301 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 360
Query: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
NETLRLFP+ R+ RVCKKD+EING+FIPKG+ VM+P YALH DPKYWTEPEKF PER
Sbjct: 361 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 653 bits (1684), Expect = 0.0
Identities = 313/418 (74%), Positives = 357/418 (85%)
Query: 1 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60
MDLIPN A+ETW+L+A SLVLLY+YGT +H LFK+LGIPGPTPLP LG +L Y +GLW F
Sbjct: 1 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF 60
Query: 61 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120
D EC +KYG+MWG YEGQ P+L I DPD+I+TVLVKECYSVFTN+ LGP+GF+KSA+S
Sbjct: 61 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL 120
Query: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180
AEDEEWKRIR+LLSP FTS K KEM PII+Q GD+LVR+LR+EAE K + LKD FGAY+
Sbjct: 121 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS 180
Query: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240
MDVITGT FGVN+DSLNNPQDPF+++ KK LK FLDP L I LFPFLTPVFEALN+ L
Sbjct: 181 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL 240
Query: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300
FPKD +FL S+ RMK+SRL DKQKHR+DF Q MIDSQNSKET+SHKALSDLEL AQSI
Sbjct: 241 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI 300
Query: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
I IFA Y+TTS+ L F +YELATHPDVQQKLQ+EIDAVLPNKAP TYDA+VQMEYLDMVV
Sbjct: 301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV 360
Query: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
NETLRLFPV R+ R CKKD+EINGVFIPKG V++P YALHHDPKYWTEPE+F PER
Sbjct: 361 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPER 418
>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
[Homo sapiens]
Length = 503
Score = 631 bits (1628), Expect = 0.0
Identities = 298/418 (71%), Positives = 357/418 (85%)
Query: 1 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60
MDLIPN A+ETW+L+A SL+LLY+YGT +H LFKKLGIPGPTPLPFLG L + +G W F
Sbjct: 1 MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF 60
Query: 61 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120
D EC +KY ++WG+Y+ QQPML I DPDMIKTVLVKECYSVFTN+ P GP+GF+K+A+S
Sbjct: 61 DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI 120
Query: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180
AEDEEWKRIR+LLSP FTS K KEMVPII+Q GD+LVR+LR+EAE K + LK FGAY+
Sbjct: 121 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS 180
Query: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240
MDVIT T FGV++DSLNNPQDPF++N KKLL+ + LDPF+L I +FPFLTP+ EALNI +
Sbjct: 181 MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV 240
Query: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300
FP+ V FL S++++KE RLK+ QKHRVDF Q MIDSQNSK++++HKALSDLEL+AQSI
Sbjct: 241 FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI 300
Query: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
I IFA Y+TTS+ L FI+YELATHPDVQQK+Q+EID VLPNKAP TYD ++Q+EYLDMVV
Sbjct: 301 IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV 360
Query: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
NETLRLFPV R+ RVCKKD+EING+FIPKG+ VM+P Y LHHDPKYWTEPEKF PER
Sbjct: 361 NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPER 418
>gi|195972900 thromboxane A synthase 1, platelet isoform TXS-II
[Homo sapiens]
Length = 460
Score = 239 bits (610), Expect = 3e-63
Identities = 148/447 (33%), Positives = 229/447 (51%), Gaps = 37/447 (8%)
Query: 6 NFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECN 65
N M T L L LL Y T + +KLG+ P P PF+G + F+ +G W E
Sbjct: 13 NGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELR 72
Query: 66 EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLG-PMGFLKSALSFAEDE 124
+ YG + G Y G++ +VI +PDMIK VLV E +S FTN+M G + ++ F D+
Sbjct: 73 KLYGPLCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDK 131
Query: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
W+ +R L AF+ K EMVP+ISQ D+L+ L++ AE+ + +++ + YT DV+
Sbjct: 132 RWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVV 191
Query: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD 244
FG +DS P+DPF+K+ K+ + P L+L+ FP + + +
Sbjct: 192 ASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDE 251
Query: 245 VTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKE------------------ 283
+ F I + L+D+Q + R DF Q ++D+++S
Sbjct: 252 LNGFFNKLIRNV--IALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTG 309
Query: 284 -----TKSH------KALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332
++ H + L+ E+V Q+ I + A Y+ + TL F Y LAT+PD Q+KL
Sbjct: 310 CKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLL 369
Query: 333 EEIDAVLPNKAPVTYDALVQ-MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKG 391
E+D + +L + + YLDMV+ ETLR++P R TR +D E+ G IP G
Sbjct: 370 REVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAG 429
Query: 392 LAVMVPIYALHHDPKYWTEPEKFCPER 418
+ + + ALHHDP++W PE F PER
Sbjct: 430 AVLEMAVGALHHDPEHWPSPETFNPER 456
>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 239 bits (610), Expect = 3e-63
Identities = 148/447 (33%), Positives = 229/447 (51%), Gaps = 37/447 (8%)
Query: 6 NFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECN 65
N M T L L LL Y T + +KLG+ P P PF+G + F+ +G W E
Sbjct: 13 NGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELR 72
Query: 66 EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLG-PMGFLKSALSFAEDE 124
+ YG + G Y G++ +VI +PDMIK VLV E +S FTN+M G + ++ F D+
Sbjct: 73 KLYGPLCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDK 131
Query: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
W+ +R L AF+ K EMVP+ISQ D+L+ L++ AE+ + +++ + YT DV+
Sbjct: 132 RWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVV 191
Query: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD 244
FG +DS P+DPF+K+ K+ + P L+L+ FP + + +
Sbjct: 192 ASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDE 251
Query: 245 VTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKE------------------ 283
+ F I + L+D+Q + R DF Q ++D+++S
Sbjct: 252 LNGFFNKLIRNV--IALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTG 309
Query: 284 -----TKSH------KALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332
++ H + L+ E+V Q+ I + A Y+ + TL F Y LAT+PD Q+KL
Sbjct: 310 CKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLL 369
Query: 333 EEIDAVLPNKAPVTYDALVQ-MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKG 391
E+D + +L + + YLDMV+ ETLR++P R TR +D E+ G IP G
Sbjct: 370 REVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAG 429
Query: 392 LAVMVPIYALHHDPKYWTEPEKFCPER 418
+ + + ALHHDP++W PE F PER
Sbjct: 430 AVLEMAVGALHHDPEHWPSPETFNPER 456
>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 239 bits (610), Expect = 3e-63
Identities = 148/447 (33%), Positives = 229/447 (51%), Gaps = 37/447 (8%)
Query: 6 NFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECN 65
N M T L L LL Y T + +KLG+ P P PF+G + F+ +G W E
Sbjct: 13 NGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELR 72
Query: 66 EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLG-PMGFLKSALSFAEDE 124
+ YG + G Y G++ +VI +PDMIK VLV E +S FTN+M G + ++ F D+
Sbjct: 73 KLYGPLCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDK 131
Query: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
W+ +R L AF+ K EMVP+ISQ D+L+ L++ AE+ + +++ + YT DV+
Sbjct: 132 RWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVV 191
Query: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD 244
FG +DS P+DPF+K+ K+ + P L+L+ FP + + +
Sbjct: 192 ASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDE 251
Query: 245 VTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKE------------------ 283
+ F I + L+D+Q + R DF Q ++D+++S
Sbjct: 252 LNGFFNKLIRNV--IALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTG 309
Query: 284 -----TKSH------KALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332
++ H + L+ E+V Q+ I + A Y+ + TL F Y LAT+PD Q+KL
Sbjct: 310 CKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLL 369
Query: 333 EEIDAVLPNKAPVTYDALVQ-MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKG 391
E+D + +L + + YLDMV+ ETLR++P R TR +D E+ G IP G
Sbjct: 370 REVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAG 429
Query: 392 LAVMVPIYALHHDPKYWTEPEKFCPER 418
+ + + ALHHDP++W PE F PER
Sbjct: 430 AVLEMAVGALHHDPEHWPSPETFNPER 456
>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
Length = 505
Score = 130 bits (326), Expect = 3e-30
Identities = 115/426 (26%), Positives = 202/426 (47%), Gaps = 35/426 (8%)
Query: 13 VLVATSLVLLYIYGTHSHK--LFKKLGI-PGPTPLPFLGTILFYLRGLWNFDRECNEKYG 69
+L+ SL+L + + + + + L + P P F G FY + + EKY
Sbjct: 18 ILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKLMEKYP 77
Query: 70 EMWGLYEGQQPMLV-IMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKR 128
L+ G M + DPD K +L ++ + L ++ L + +WK+
Sbjct: 78 CAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILE--SWVGRGLVTLDGSKWKK 135
Query: 129 IRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTL 188
R ++ P F K + ++S+ M++ + + + L T+D I
Sbjct: 136 HRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCA 195
Query: 189 FG----VNLDSLNNPQDPFLKNMKKLLKLDF--LDPFLL---LISLFPFLTPVFEALNIG 239
F + LDS D +LK + L K+ ++ FL L+ F +F N
Sbjct: 196 FSHQGSIQLDST---LDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFN-- 250
Query: 240 LFPKDVTHFLKNSIERMKESRLKDK------QKHRVDFFQQMIDSQNSKETKSHKALSDL 293
+++ F + I+ KES LKDK QK R DF ++ S ++++ K S+
Sbjct: 251 ---QELHQFTEKVIQDRKES-LKDKLKQDTTQKRRWDFLDILL----SAKSENTKDFSEA 302
Query: 294 ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQM 353
+L A+ +FA +DTTS+ + +I+Y LA +P+ QQ+ ++EI +L + + +T++ L QM
Sbjct: 303 DLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQM 362
Query: 354 EYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPE 412
Y M + E LRL+ V ++R+ K I +G +P G+ V + I+ALHH+P +W +P+
Sbjct: 363 PYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQ 422
Query: 413 KFCPER 418
F P R
Sbjct: 423 VFNPLR 428
>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
[Homo sapiens]
Length = 531
Score = 127 bits (318), Expect = 2e-29
Identities = 97/356 (27%), Positives = 178/356 (50%), Gaps = 26/356 (7%)
Query: 80 PMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMG-FLKSALSFAEDEEWKRIRTLLSPAFT 138
P+LV++ PD IK +L + + G + +L L ++ ++W R R LL+PAF
Sbjct: 105 PLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFH 164
Query: 139 SVKFKEMVPIISQCGDMLVRSLRQEAENSK-SINLKDFFGAYTMDVITGTLFGVNLDSLN 197
K + I +Q D++ R AE S S+++ + T+D + +F N +
Sbjct: 165 FDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYN----S 220
Query: 198 NPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD----VTHFLKNSI 253
N Q+ + +++L L L +L ++ G + V HF I
Sbjct: 221 NCQEKMSDYISAIIELSALS-VRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVI 279
Query: 254 ERMK--------ESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFA 305
+ + E+ LK KQ +DF ++ +++ + K LSD ++ A++ +F
Sbjct: 280 QERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARD----EDGKELSDEDIRAEADTFMFE 335
Query: 306 AYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNK--APVTYDALVQMEYLDMVVNET 363
+DTTS+ + ++++ LA +P+ Q+K +EEI V+ + + +D L Q+ + M + E+
Sbjct: 336 GHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKES 395
Query: 364 LRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
LR +P V+ V+R C +DI++ +G IPKG+ +V IY HH+P W + + + P R
Sbjct: 396 LRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYR 451
>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
[Homo sapiens]
Length = 525
Score = 120 bits (300), Expect = 3e-27
Identities = 94/382 (24%), Positives = 179/382 (46%), Gaps = 43/382 (11%)
Query: 63 ECNEKYGEM--WGLYEGQQPMLVIMDPDMIKTVLVK----ECYSVFTNQMPLGPMGFLKS 116
E E+Y M L+ G PM+ + + + ++ +L + S++ P +G L S
Sbjct: 79 EYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTS 138
Query: 117 ALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFF 176
+W+ R +L+P F ++ + I+++ ++LV+ L + N ++ N +
Sbjct: 139 T-----GNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHI-NQEAFNCFFYI 192
Query: 177 GAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLD---PFLLLISLFPFLTPVF 233
+D+I T G N+ + +N +++ + ++ ++ F P+L L + +
Sbjct: 193 TLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGW 252
Query: 234 EALNIGLFPKDVTHFLKNSI--ERMKESRL--------------KDKQKHRVDFFQQMID 277
E + H NS+ ER E K+K++ +D + D
Sbjct: 253 EHKK----SLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTD 308
Query: 278 SQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDA 337
+ ++ LS ++ + +F +DTT+ + + +Y L ++P+VQ+K+ E+D
Sbjct: 309 DEGNR-------LSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDD 361
Query: 338 VL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMV 396
V + P T + L ++ YL+ V+ ETLRLFP V R +D E+ G + KG ++
Sbjct: 362 VFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVI 421
Query: 397 PIYALHHDPKYWTEPEKFCPER 418
YALH DP+Y+ PE+F PER
Sbjct: 422 IPYALHRDPRYFPNPEEFQPER 443
>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
[Homo sapiens]
Length = 509
Score = 119 bits (297), Expect = 7e-27
Identities = 98/391 (25%), Positives = 181/391 (46%), Gaps = 18/391 (4%)
Query: 39 PGPTPLPFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQ-QPMLVIMDPDMIKTVLVKE 97
P P FLG F E EKY + + G Q I DPD KT+L +
Sbjct: 47 PAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRT 106
Query: 98 CYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLV 157
Q P+ L L+ + +W + R LL+P F K + +++ M++
Sbjct: 107 DPKSQYLQKFSPPL--LGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMML 164
Query: 158 RSLRQEAENSK-SINLKDFFGAYTMDVITGTLFGVNLD-SLNNPQDPFLKNMKKLLKLDF 215
+ S+ + + + ++D+I F + N+ DP+ K + +L K+ F
Sbjct: 165 DKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIF 224
Query: 216 LDPFLLLI--SLFPFLTPV---FEALN--IGLFPKDVTHFLKNSIERMKESRLKDKQKHR 268
+ LL + L+P F+ L+ + + + K S++ + K+K
Sbjct: 225 HRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRK-- 282
Query: 269 VDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQ 328
+Q +D S + +S + SD+++ ++ + A +DT + ++ +I+Y LA +P+ Q
Sbjct: 283 ---YQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQ 339
Query: 329 QKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVF 387
++ +EE+ +L + + +T+D L +M Y M + ET RL P V ++R K + +G
Sbjct: 340 ERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCT 399
Query: 388 IPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
+P G+ V++ I+ LHH+P W P+ F P R
Sbjct: 400 LPAGITVVLSIWGLHHNPAVWKNPKVFDPLR 430
>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
[Homo sapiens]
Length = 520
Score = 118 bits (296), Expect = 9e-27
Identities = 94/371 (25%), Positives = 175/371 (47%), Gaps = 30/371 (8%)
Query: 68 YGEMWGLYEGQQPMLV-IMDPDMIKTVLVKECYSVFTNQMPLGPMG-FLKSALSFAEDEE 125
+G+M + G +V I P IK VL V +++ + +L L + E+
Sbjct: 84 FGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEK 143
Query: 126 WKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEA-ENSKSINLKDFFGAYTMDVI 184
W R R +L+PAF K + I ++ +++ + A E S +++ + T+D +
Sbjct: 144 WSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSL 203
Query: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFL-----DPFLLLISLFPFLTPVFEALNIG 239
+F + P + + +L+L L LL I +LTP +
Sbjct: 204 QKCVFSFDSHCQEKPSE----YIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRF--- 256
Query: 240 LFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQ---------MIDSQNSKETKSHKAL 290
+ + + + + + R + VD F Q ID + + K L
Sbjct: 257 ---RRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKL 313
Query: 291 SDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP--VTYD 348
SD ++ A++ +F +DTT++ L +++Y LA HP+ Q++ ++E+ +L ++ P + +D
Sbjct: 314 SDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWD 373
Query: 349 ALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKY 407
L Q+ +L M + E+LRL P V V+R C +DI + +G IPKG+ ++ ++ HH+P
Sbjct: 374 DLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAV 433
Query: 408 WTEPEKFCPER 418
W +PE + P R
Sbjct: 434 WPDPEVYDPFR 444
>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 117 bits (294), Expect = 1e-26
Identities = 95/366 (25%), Positives = 174/366 (47%), Gaps = 45/366 (12%)
Query: 80 PMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLK----SALSFAEDEEWKRIRTLLSP 135
P+L++ PD+I+ + +V M GFLK L + ++W R R +L+P
Sbjct: 97 PLLILCHPDIIRPITSASA-AVAPKDMIF--YGFLKPWLGDGLLLSGGDKWSRHRRMLTP 153
Query: 136 AFTSVKFKEMVPIISQCGDMLV-RSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLD 194
AF K + I ++ +++ + R +E S +++ + T+D + +F +
Sbjct: 154 AFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESN 213
Query: 195 SLNNPQDPFL-----------KNMKKLLKLDFL-------DPFLLLISLF-PFLTPVFEA 235
P + +N + LL DFL F L F V +
Sbjct: 214 CQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQE 273
Query: 236 LNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLEL 295
L + + FLKN K K K +DF ++ S++ + K LSD ++
Sbjct: 274 RRCTLPTQGIDDFLKN----------KAKSK-TLDFIDVLLLSKD----EDGKELSDEDI 318
Query: 296 VAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP--VTYDALVQM 353
A++ +F +DTT++ L +++Y LA HP+ Q++ ++E+ +L ++ P + +D L Q+
Sbjct: 319 RAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQL 378
Query: 354 EYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPE 412
+L M + E+LRL P V ++R C +D + +G IPKG+ ++ I +H++P W +PE
Sbjct: 379 PFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPE 438
Query: 413 KFCPER 418
+ P R
Sbjct: 439 VYDPFR 444
>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 117 bits (294), Expect = 1e-26
Identities = 95/366 (25%), Positives = 174/366 (47%), Gaps = 45/366 (12%)
Query: 80 PMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLK----SALSFAEDEEWKRIRTLLSP 135
P+L++ PD+I+ + +V M GFLK L + ++W R R +L+P
Sbjct: 97 PLLILCHPDIIRPITSASA-AVAPKDMIF--YGFLKPWLGDGLLLSGGDKWSRHRRMLTP 153
Query: 136 AFTSVKFKEMVPIISQCGDMLV-RSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLD 194
AF K + I ++ +++ + R +E S +++ + T+D + +F +
Sbjct: 154 AFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESN 213
Query: 195 SLNNPQDPFL-----------KNMKKLLKLDFL-------DPFLLLISLF-PFLTPVFEA 235
P + +N + LL DFL F L F V +
Sbjct: 214 CQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQE 273
Query: 236 LNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLEL 295
L + + FLKN K K K +DF ++ S++ + K LSD ++
Sbjct: 274 RRCTLPTQGIDDFLKN----------KAKSK-TLDFIDVLLLSKD----EDGKELSDEDI 318
Query: 296 VAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP--VTYDALVQM 353
A++ +F +DTT++ L +++Y LA HP+ Q++ ++E+ +L ++ P + +D L Q+
Sbjct: 319 RAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQL 378
Query: 354 EYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPE 412
+L M + E+LRL P V ++R C +D + +G IPKG+ ++ I +H++P W +PE
Sbjct: 379 PFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPE 438
Query: 413 KFCPER 418
+ P R
Sbjct: 439 VYDPFR 444
>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
[Homo sapiens]
Length = 520
Score = 117 bits (293), Expect = 2e-26
Identities = 87/358 (24%), Positives = 168/358 (46%), Gaps = 29/358 (8%)
Query: 80 PMLVIMDPDMIKTVL-----VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLS 134
P++ + PD++++V+ + + VF + +L L + ++W+ R LL+
Sbjct: 97 PIINLCHPDIVRSVINTSDAITDKDIVFYKTLK----PWLGDGLLLSVGDKWRHHRRLLT 152
Query: 135 PAFTSVKFKEMVPIISQCGDML-VRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNL 193
PAF K + I S+ +++ + R E S +++ + T+D + +F +
Sbjct: 153 PAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFSFDS 212
Query: 194 DSLNNPQDPFLKNMK-KLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNS 252
+ P + M+ L + + F FLTP + + +
Sbjct: 213 NCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFH------RACRLVHDF 266
Query: 253 IERMKESRLKDKQKHRVDFFQQ---------MIDSQNSKETKSHKALSDLELVAQSIIII 303
+ + + R + VD F Q ID E K+ K LSD ++ A++ +
Sbjct: 267 TDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFM 326
Query: 304 FAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP--VTYDALVQMEYLDMVVN 361
F +DTT++ L +++Y LA HP+ Q++ ++E+ +L ++ P + +D L Q+ +L M +
Sbjct: 327 FGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLK 386
Query: 362 ETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
E+LRL P + R C +D+ + + IPKG + I+A+HH+P W +PE + P R
Sbjct: 387 ESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFR 444
>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
[Homo sapiens]
Length = 524
Score = 115 bits (287), Expect = 1e-25
Identities = 84/355 (23%), Positives = 172/355 (48%), Gaps = 23/355 (6%)
Query: 80 PMLVIMDPDMIKTVL-VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFT 138
P +V+ PD I+++ + N +L + + ++W R R +L+PAF
Sbjct: 97 PFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFH 156
Query: 139 SVKFKEMVPIISQCGDMLVRSLRQEA-ENSKSINLKDFFGAYTMDVITGTLFGVNLDSLN 197
K + I ++ ++++ + A E S +++ + T+D + +F +
Sbjct: 157 FNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQE 216
Query: 198 NPQDPFLKNMKKLLKLDFLDPFLLL-ISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERM 256
P + ++ ++ +L + +L+ + + H +++ R
Sbjct: 217 RPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRAC---RLVHDFTDAVIRE 273
Query: 257 KESRL---------KDKQKHR-VDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAA 306
+ L KDK K + +DF ++ S++ + KALSD ++ A++ +F
Sbjct: 274 RRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKD----EDGKALSDEDIRAEADTFMFGG 329
Query: 307 YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP--VTYDALVQMEYLDMVVNETL 364
+DTT++ L +++Y LA HP+ Q++ ++E+ +L ++ P + +D L Q+ +L M V E+L
Sbjct: 330 HDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESL 389
Query: 365 RLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
RL P ++R C +DI + +G IPKG+ ++ I +HH+P W +PE + P R
Sbjct: 390 RLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFR 444
>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
[Homo sapiens]
Length = 519
Score = 111 bits (278), Expect = 1e-24
Identities = 86/357 (24%), Positives = 167/357 (46%), Gaps = 28/357 (7%)
Query: 77 GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPA 136
G + + + DPD +K +L + + L P ++ L + W + R +L+PA
Sbjct: 92 GGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAP--WIGYGLLLLNGQTWFQHRRMLTPA 149
Query: 137 FTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG----VN 192
F K V +++ +++ + + + T+D I F +
Sbjct: 150 FHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQ 209
Query: 193 LDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPK---DVTHFL 249
+D + + ++ L+ F + + F ++ + G + + H
Sbjct: 210 VDRNSQSYIQAISDLNNLV-------FSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQH 262
Query: 250 KNSIERMKESRL-------KDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIII 302
+ + ++++++L K K+K +DF ++ ++ ++ LSD +L A+
Sbjct: 263 TDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDLRAEVDTF 318
Query: 303 IFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNE 362
+F +DTT++ + +I+Y LATHP Q++ +EEI ++L + A +T++ L QM Y M + E
Sbjct: 319 MFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKE 378
Query: 363 TLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
LRL+P V + R + +G +PKG+ V++ IY LHH+PK W PE F P R
Sbjct: 379 ALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFR 435
>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
[Homo sapiens]
Length = 519
Score = 110 bits (276), Expect = 2e-24
Identities = 85/357 (23%), Positives = 166/357 (46%), Gaps = 28/357 (7%)
Query: 77 GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPA 136
G + + + DPD +K +L + + L P + L + W + R +L+PA
Sbjct: 92 GGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPR--IGYGLLLLNGQTWFQHRRMLTPA 149
Query: 137 FTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG----VN 192
F + K V +++ +++ + + + T+D I + F +
Sbjct: 150 FHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQ 209
Query: 193 LDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPK---DVTHFL 249
+D + + ++ L+ F + + F ++ + G + + H
Sbjct: 210 VDRNSQSYIQAISDLNSLV-------FCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQH 262
Query: 250 KNSIERMKESRL-------KDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIII 302
+ + ++++++L K K+K +DF ++ ++ ++ LSD +L A+
Sbjct: 263 TDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDLRAEVDTF 318
Query: 303 IFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNE 362
+F +DTT++ + +I+Y LATHP Q++ +EEI +L + A +T++ L QM Y M + E
Sbjct: 319 MFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKE 378
Query: 363 TLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
LRL+P V + R + +G +PKG+ V++ IY LHH+PK W E F P R
Sbjct: 379 ALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSR 435
>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
[Homo sapiens]
Length = 520
Score = 109 bits (273), Expect = 4e-24
Identities = 85/358 (23%), Positives = 169/358 (47%), Gaps = 29/358 (8%)
Query: 80 PMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMG-FLKSALSFAEDEEWKRIRTLLSPAFT 138
P+L + PD+I++V+ ++ + +L L + ++W R R +L+PAF
Sbjct: 97 PLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFH 156
Query: 139 SVKFKEMVPIISQCGDMLVRSLRQEA-ENSKSINLKDFFGAYTMDVITGTLFGVNLDSLN 197
K + I ++ +++ + A E S +++ + T+D + +F +
Sbjct: 157 FNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQE 216
Query: 198 NPQDPFLKNMKKLLKLDFL-----DPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNS 252
P + + +L+L L LL I +LTP + + + +
Sbjct: 217 KPSE----YIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRF------RRACRLVHDF 266
Query: 253 IERMKESRLKDKQKHRVDFFQQ---------MIDSQNSKETKSHKALSDLELVAQSIIII 303
+ + + R + VD F Q ID + + K LSD ++ A++ +
Sbjct: 267 TDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFM 326
Query: 304 FAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP--VTYDALVQMEYLDMVVN 361
F +DTT++ L +++Y LA HP+ Q++ ++E+ +L ++ P + +D L + +L M +
Sbjct: 327 FEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMK 386
Query: 362 ETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
E+LRL P V ++R +DI + +G IPKG+ ++ ++ HH+P W +PE + P R
Sbjct: 387 ESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFR 444
>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
[Homo sapiens]
Length = 502
Score = 105 bits (261), Expect = 1e-22
Identities = 97/393 (24%), Positives = 177/393 (45%), Gaps = 27/393 (6%)
Query: 39 PGPTPLPFLGTILFYLRGLWNFDRECN---EKYGEMWGLYEGQQPMLVIMDPDMIKTVLV 95
PGP LPFLG F+L E +KYG ++ L G ++I +IK L+
Sbjct: 45 PGPWRLPFLGN--FFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALI 102
Query: 96 KECYSVFTNQMPLGPMG---FLKSALSFAEDEEWKRIRTLLSPAFTSVKF--KEMVPIIS 150
+ F N+ P+ PM F K+ L + + WK R A + K + I
Sbjct: 103 HMDQN-FGNR-PVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQ 160
Query: 151 QCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKL 210
+ L ++++E N + + ++I FG + QD + + + KL
Sbjct: 161 EEAQHLTEAIKEE--NGQPFDPHFKINNAVSNIICSITFGERFEY----QDSWFQQLLKL 214
Query: 211 L-KLDFLDPFLL--LISLFPFLTPVFEALNIGLFP--KDVTHFLKNSIERMKESRLKDKQ 265
L ++ +L+ L ++FP++ + LF K + F+ + I++ ++ +
Sbjct: 215 LDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAET 274
Query: 266 KHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHP 325
+ +D + + + T S + L+ ++ + FA +TTSTTL + + +A +P
Sbjct: 275 RDFIDAYLKEMSKHTGNPTSS---FHEENLICSTLDLFFAGTETTSTTLRWALLYMALYP 331
Query: 326 DVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVS-RVTRVCKKDIEIN 384
++Q+K+Q EID V+ + A M Y + V++E R+ ++ V R D +
Sbjct: 332 EIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLA 391
Query: 385 GVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE 417
G +PKG ++ + ALH DP W P+ F P+
Sbjct: 392 GYHLPKGTMILTNLTALHRDPTEWATPDTFNPD 424
>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
[Homo sapiens]
Length = 491
Score = 102 bits (255), Expect = 5e-22
Identities = 97/399 (24%), Positives = 180/399 (45%), Gaps = 39/399 (9%)
Query: 39 PGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKE 97
PGP PLP LG +L RGL EKYG+++ ++ G +P++++ + I+ LV +
Sbjct: 32 PGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDK 91
Query: 98 CYSVFTNQMPLGPMG--FLKSALSFAEDEEWKRIR-----TLLSPAFTSVKFKEMVPIIS 150
F+ + + + F + FA WK +R T+ +E + +
Sbjct: 92 A-EAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEA 150
Query: 151 QCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKL 210
QC L+ LR+ ++ F + T ++I +FG + QD + K+
Sbjct: 151 QC---LIEELRKS--KGALMDPTFLFQSITANIICSIVFGKRF----HYQD---QEFLKM 198
Query: 211 LKLDFLDPFLLLISLFPFLTPVFEALNIGLFP----------KDVTHFLKNSIERMKESR 260
L L F F L+ S+F L +F + FP +++ ++ +S+E+ +E+
Sbjct: 199 LNL-FYQTFSLISSVFGQLFELFSGF-LKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL 256
Query: 261 LKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYE 320
K +D + ++ + S +H S L ++ + FA +TTSTTL +
Sbjct: 257 DPSAPKDLIDTYLLHMEKEKSN---AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLL 313
Query: 321 LATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSR-VTRVCK 378
+ +P V +++ EI+ V+ P++ P +D +M Y + V+ E R ++ V +
Sbjct: 314 MLKYPHVAERVYREIEQVIGPHRPPELHDR-AKMPYTEAVIYEIQRFSDLLPMGVPHIVT 372
Query: 379 KDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE 417
+ G IPK V + + HDP Y+ +P+ F P+
Sbjct: 373 QHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPD 411
>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
[Homo sapiens]
Length = 490
Score = 102 bits (254), Expect = 6e-22
Identities = 106/416 (25%), Positives = 188/416 (45%), Gaps = 26/416 (6%)
Query: 13 VLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEM 71
VL + L+LL I+ S + KL PGPTPLP +G IL ++ + ++ YG +
Sbjct: 8 VLCLSCLLLLSIWRQSSGR--GKLP-PGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64
Query: 72 WGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQ--MPLGPMGFLKSALSFAEDEEWKRI 129
+ LY G + M+V+ +++K L+ + F+ + PL + F+ + WK I
Sbjct: 65 FTLYFGLERMVVLHGYEVVKEALI-DLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEI 123
Query: 130 R-----TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
R TL + ++ V ++C LV LR+ + + G +VI
Sbjct: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARC---LVEELRKT--KASPCDPTFILGCAPCNVI 178
Query: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFL--DPFLLLISLFPFLTPVFEALNIGLFP 242
+F D + FL M+KL + + P++ + + FP + F + L
Sbjct: 179 CSIIFQKRFDYKDQQ---FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLL- 234
Query: 243 KDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIII 302
K++ + +E++KE + + DF + ++ + LV + +
Sbjct: 235 KNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADL 294
Query: 303 IFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVN 361
+ A +TTSTTL + + L HP+V K+QEEI+ V+ N++P D M Y D VV+
Sbjct: 295 LGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDR-GHMPYTDAVVH 353
Query: 362 ETLRLFPVV-SRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCP 416
E R ++ + + D++ IPKG ++ + ++ HD K + PE F P
Sbjct: 354 EVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDP 409
>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
Length = 500
Score = 102 bits (254), Expect = 6e-22
Identities = 92/422 (21%), Positives = 184/422 (43%), Gaps = 34/422 (8%)
Query: 13 VLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDR---------- 62
VL+A L +++ S + IPGP FL L +L W D
Sbjct: 12 VLLAFGLCCTFVHRARS----RYEHIPGPPRPSFL---LGHLPCFWKKDEVGGRVLQDVF 64
Query: 63 -ECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTN-----QMPLGPMGFLKS 116
+ +KYG + + + +++ P+ +K L+ Y+ + Q G F +
Sbjct: 65 LDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQG 124
Query: 117 ALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFF 176
+S E W + R ++ AF+ ++ ++ + LV L +A+ ++++D
Sbjct: 125 LVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDML 184
Query: 177 GAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEAL 236
MD++ FG+ L Q P + +K +L+ L L + E
Sbjct: 185 TYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVR 244
Query: 237 NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELV 296
F + V ++ ++R +E+ LK ++ D Q++ ++ A D L+
Sbjct: 245 ESIRFLRQVG---RDWVQRRREA-LKRGEEVPADILTQILKAEEG-------AQDDEGLL 293
Query: 297 AQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYL 356
+ A ++T++ L F + EL+ P++ +LQ E+D V+ +K + ++ L +++YL
Sbjct: 294 DNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYL 353
Query: 357 DMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCP 416
V+ E+LRL+P R+ +++ I+GV +P ++ Y + Y+ +P F P
Sbjct: 354 SQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNP 413
Query: 417 ER 418
+R
Sbjct: 414 DR 415
>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
[Homo sapiens]
Length = 490
Score = 102 bits (253), Expect = 8e-22
Identities = 104/415 (25%), Positives = 191/415 (46%), Gaps = 24/415 (5%)
Query: 13 VLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEM 71
VL + L+LL ++ S + KL PGPTPLP +G IL ++ + ++ YG +
Sbjct: 8 VLCLSCLLLLSLWRQSSGR--GKLP-PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPV 64
Query: 72 WGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQ--MPLGPMGFLKSALSFAEDEEWKRI 129
+ LY G +P++V+ + +K L+ + F+ + PL + F+ ++WK I
Sbjct: 65 FTLYFGLKPIVVLHGYEAVKEALI-DLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEI 123
Query: 130 R-----TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
R TL + ++ V ++C LV LR+ + + G +VI
Sbjct: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARC---LVEELRKT--KASPCDPTFILGCAPCNVI 178
Query: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD 244
+F D + ++ + + +K+ P++ + + F + F + L K+
Sbjct: 179 CSIIFHKRFDYKDQQFLNLMEKLNENIKI-LSSPWIQICNNFSPIIDYFPGTHNKLL-KN 236
Query: 245 VTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIF 304
V +E++KE + + DF + + KE + + +E + + + +F
Sbjct: 237 VAFMKSYILEKVKEHQESMDMNNPQDFIDCFL-MKMEKEKHNQPSEFTIESLENTAVDLF 295
Query: 305 AA-YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVNE 362
A +TTSTTL + + L HP+V K+QEEI+ V+ N++P D M Y D VV+E
Sbjct: 296 GAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDR-SHMPYTDAVVHE 354
Query: 363 TLRLFPVV-SRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCP 416
R ++ + + DI+ IPKG +++ + ++ HD K + PE F P
Sbjct: 355 VQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDP 409
>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
isoform a [Homo sapiens]
Length = 512
Score = 99.8 bits (247), Expect = 4e-21
Identities = 84/356 (23%), Positives = 161/356 (45%), Gaps = 44/356 (12%)
Query: 82 LVIMDPDMIKTVLVK------ECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSP 135
L I +PD K V + + Y F + G L E +W + R LL+P
Sbjct: 92 LNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRG--------LLVLEGPKWLQHRKLLTP 143
Query: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDS 195
F K V + ++ +++ ++A KS ++ G ++ + FG
Sbjct: 144 GFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTG 203
Query: 196 LNNPQDPF---------LKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVT 246
L + +D L ++L+ + + F+ +LTP L V
Sbjct: 204 LGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIY------WLTPHGRRF---LRACQVA 254
Query: 247 HFLKNSIERMKESRLKDKQ-------KHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS 299
H + + R +++ L+D++ + +DF ++ +++ + K LSD +L A+
Sbjct: 255 HDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK----LSDADLRAEV 310
Query: 300 IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMV 359
+F +DTT++ + + +Y +A +P+ Q + +EE+ +L ++ +D L +M YL M
Sbjct: 311 DTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMC 370
Query: 360 VNETLRLFPVVSRVTRVCKKDIE-INGVFIPKGLAVMVPIYALHHDPKYWTEPEKF 414
+ E+ RL+P V +V R K + ++G +P G + + IYALH + W +PE F
Sbjct: 371 IKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVF 426
>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
isoform b [Homo sapiens]
Length = 511
Score = 99.0 bits (245), Expect = 7e-21
Identities = 83/355 (23%), Positives = 160/355 (45%), Gaps = 43/355 (12%)
Query: 82 LVIMDPDMIKTVLVK------ECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSP 135
L I +PD K V + + Y F + G L E +W + R LL+P
Sbjct: 92 LNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRG--------LLVLEGPKWLQHRKLLTP 143
Query: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDS 195
F K V + ++ +++ ++A KS ++ G ++ + FG
Sbjct: 144 GFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTG 203
Query: 196 LNNPQDPF--------LKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTH 247
L + + L ++L+ + + F+ +LTP L V H
Sbjct: 204 LGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIY------WLTPHGRRF---LRACQVAH 254
Query: 248 FLKNSIERMKESRLKDKQ-------KHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300
+ + R +++ L+D++ + +DF ++ +++ + K LSD +L A+
Sbjct: 255 DHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK----LSDADLRAEVD 310
Query: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
+F +DTT++ + + +Y +A +P+ Q + +EE+ +L ++ +D L +M YL M +
Sbjct: 311 TFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCI 370
Query: 361 NETLRLFPVVSRVTRVCKKDIE-INGVFIPKGLAVMVPIYALHHDPKYWTEPEKF 414
E+ RL+P V +V R K + ++G +P G + + IYALH + W +PE F
Sbjct: 371 KESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVF 425
>gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide 1
precursor [Homo sapiens]
Length = 531
Score = 95.9 bits (237), Expect = 6e-20
Identities = 91/367 (24%), Positives = 153/367 (41%), Gaps = 24/367 (6%)
Query: 67 KYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFA----E 122
KYG MW Y G Q + + +++ V+ +E N M L + L++ E
Sbjct: 91 KYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTE 150
Query: 123 DEEWKRIRT-----LLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFG 177
W ++R LL PA ++ +I L + + A ++ ++ F
Sbjct: 151 GHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFY 210
Query: 178 AYTMDVITGTLFGVNLDSLNN--PQDP--FLKNMKKLLKLDFLDPFLLLIS--LFPFLTP 231
+ ++ I LF + L P+D F++++ + + FL + + PF
Sbjct: 211 YFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKR 270
Query: 232 VFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALS 291
+ N + F K I+ E Q D Q S + LS
Sbjct: 271 YLDGWNA------IFSFGKKLIDEKLEDMEAQLQAAGPDGIQV---SGYLHFLLASGQLS 321
Query: 292 DLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALV 351
E + ++ A DTTS TL + +Y L+ P++Q+ L EE+ V+P +
Sbjct: 322 PREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFA 381
Query: 352 QMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEP 411
M L V+ ETLRL+PVV +R+ +K+IE++G PK + Y + DP ++EP
Sbjct: 382 HMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEP 441
Query: 412 EKFCPER 418
E F P R
Sbjct: 442 ESFQPHR 448
>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
[Homo sapiens]
Length = 544
Score = 94.7 bits (234), Expect = 1e-19
Identities = 66/241 (27%), Positives = 122/241 (50%), Gaps = 8/241 (3%)
Query: 182 DVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFL--TPVFEALNIG 239
++I FG D N+ L M + L++ L+ +LL+++ P+L P +
Sbjct: 230 NIICSLCFGQRFDYTNSEFKKMLGFMSRGLEI-CLNSQVLLVNICPWLYYLPFGPFKELR 288
Query: 240 LFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS 299
KD+T FLK I+ +ES ++ + +D + ++ + ++ S+ + + L
Sbjct: 289 QIEKDITSFLKKIIKDHQESLDRENPQDFIDMY--LLHMEEERKNNSNSSFDEEYLFYII 346
Query: 300 IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDM 358
+ A DTT+ +L + + ++ +PDVQ+K+ EEI+ V+ N+AP D QM Y +
Sbjct: 347 GDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDK-AQMPYTEA 405
Query: 359 VVNETLRLFPVVS-RVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE 417
+ E RL VV + + ++ + G IPKG ++ ++++H DP W +PE F P
Sbjct: 406 TIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPN 465
Query: 418 R 418
R
Sbjct: 466 R 466
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,176,866
Number of Sequences: 37866
Number of extensions: 638232
Number of successful extensions: 1767
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 1570
Number of HSP's gapped (non-prelim): 106
length of query: 420
length of database: 18,247,518
effective HSP length: 105
effective length of query: 315
effective length of database: 14,271,588
effective search space: 4495550220
effective search space used: 4495550220
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.