BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|11125768 eukaryotic translation initiation factor 2-alpha kinase 1 isoform a [Homo sapiens] (630 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|11125768 eukaryotic translation initiation factor 2-alpha kin... 1254 0.0 gi|197245437 eukaryotic translation initiation factor 2-alpha ki... 1248 0.0 gi|65287717 eukaryotic translation initiation factor 2 alpha kin... 167 4e-41 gi|134304838 eukaryotic translation initiation factor 2-alpha ki... 134 2e-31 gi|208431829 eukaryotic translation initiation factor 2-alpha ki... 106 6e-23 gi|208431827 eukaryotic translation initiation factor 2-alpha ki... 103 4e-22 gi|4506103 eukaryotic translation initiation factor 2-alpha kina... 103 4e-22 gi|4826878 oxidative-stress responsive 1 [Homo sapiens] 81 3e-15 gi|4505373 NIMA-related kinase 2 [Homo sapiens] 80 4e-15 gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog, yea... 79 1e-14 gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens] 76 8e-14 gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens] 76 8e-14 gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens] 76 8e-14 gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 75 1e-13 gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 75 1e-13 gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 75 1e-13 gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 75 1e-13 gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinas... 74 3e-13 gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens] 73 7e-13 gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom... 73 9e-13 gi|33188459 B-Raf [Homo sapiens] 72 2e-12 gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens] 71 3e-12 gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 71 3e-12 gi|50845418 WNK lysine deficient protein kinase 3 isoform 1 [Hom... 70 4e-12 gi|50845416 WNK lysine deficient protein kinase 3 isoform 2 [Hom... 70 4e-12 gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Hom... 70 4e-12 gi|156105707 SNF related kinase [Homo sapiens] 69 1e-11 gi|156105705 SNF related kinase [Homo sapiens] 69 1e-11 gi|21359873 polo-like kinase 1 [Homo sapiens] 69 1e-11 gi|21361358 serine/threonine kinase 25 [Homo sapiens] 69 2e-11 >gi|11125768 eukaryotic translation initiation factor 2-alpha kinase 1 isoform a [Homo sapiens] Length = 630 Score = 1254 bits (3246), Expect = 0.0 Identities = 630/630 (100%), Positives = 630/630 (100%) Query: 1 MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP 60 MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP Sbjct: 1 MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP 60 Query: 61 FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH 120 FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH Sbjct: 61 FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH 120 Query: 121 NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR 180 NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR Sbjct: 121 NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR 180 Query: 181 VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI 240 VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI Sbjct: 181 VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI 240 Query: 241 QPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ 300 QPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ Sbjct: 241 QPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ 300 Query: 301 NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE 360 NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE Sbjct: 301 NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE 360 Query: 361 SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT 420 SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT Sbjct: 361 SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT 420 Query: 421 KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN 480 KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN Sbjct: 421 KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN 480 Query: 481 GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL 540 GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL Sbjct: 481 GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL 540 Query: 541 RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ 600 RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ Sbjct: 541 RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ 600 Query: 601 EKEIAELKKQLNLLSQDKGVRDDGKDGGVG 630 EKEIAELKKQLNLLSQDKGVRDDGKDGGVG Sbjct: 601 EKEIAELKKQLNLLSQDKGVRDDGKDGGVG 630 >gi|197245437 eukaryotic translation initiation factor 2-alpha kinase 1 isoform b [Homo sapiens] Length = 629 Score = 1248 bits (3230), Expect = 0.0 Identities = 629/630 (99%), Positives = 629/630 (99%), Gaps = 1/630 (0%) Query: 1 MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP 60 MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP Sbjct: 1 MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP 60 Query: 61 FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH 120 FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH Sbjct: 61 FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH 120 Query: 121 NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR 180 NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR Sbjct: 121 NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR 180 Query: 181 VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI 240 VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI Sbjct: 181 VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI 240 Query: 241 QPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ 300 QPR DRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ Sbjct: 241 QPR-DRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ 299 Query: 301 NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE 360 NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE Sbjct: 300 NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE 359 Query: 361 SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT 420 SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT Sbjct: 360 SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT 419 Query: 421 KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN 480 KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN Sbjct: 420 KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN 479 Query: 481 GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL 540 GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL Sbjct: 480 GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL 539 Query: 541 RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ 600 RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ Sbjct: 540 RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ 599 Query: 601 EKEIAELKKQLNLLSQDKGVRDDGKDGGVG 630 EKEIAELKKQLNLLSQDKGVRDDGKDGGVG Sbjct: 600 EKEIAELKKQLNLLSQDKGVRDDGKDGGVG 629 >gi|65287717 eukaryotic translation initiation factor 2 alpha kinase 4 [Homo sapiens] Length = 1649 Score = 167 bits (422), Expect = 4e-41 Identities = 157/478 (32%), Positives = 230/478 (48%), Gaps = 51/478 (10%) Query: 129 RSAKERVRQDPCEDISRIQKIRSREVALEAQT--SRYLNEFEELAILGKGGYGRVYKVRN 186 +S ++ QD E + ++ S E Q SRY EFEEL +LGKG +G V KV+N Sbjct: 550 QSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGAFGAVIKVQN 609 Query: 187 KLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVIQPRADR 246 KLDG YA+K+I I A++ ++ EV +L+ L H NIV Y+ AWIE R +R Sbjct: 610 KLDGCCYAVKRIPINPASRQF-RRIKGEVTLLSRLHHENIVRYYNAWIE-------RHER 661 Query: 247 -AAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQNNKSV 305 A P + ++DR G ++ + A P E T + + S Sbjct: 662 PAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSASA 721 Query: 306 KYTTNLVIRESGELESTLELQENGLAGLS--ASSIVEQQLPLRRNSHLEESFTSTEESSE 363 ++ S + E E + G+ S +S E + +S E+ +E Sbjct: 722 RFPA--TGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNE 779 Query: 364 ENVNFLGQ----TEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVA 419 +N + TEA ++ L+IQM+ CE S R+ +D+ Y Sbjct: 780 KNGCHESEPSVTTEAVHY--LYIQMEYCEKSTL----------RDTIDQGL--YRDTVRL 825 Query: 420 TKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDIL-----QKNT 474 ++F+E+++G+ YIH G++HRDLKP NIFL D VKIGDFGLA TD L K Sbjct: 826 WRLFREILDGLAYIHEKGMIHRDLKPVNIFLDS-DDHVKIGDFGLA-TDHLAFSADSKQD 883 Query: 475 DWTNRNGKRTPTH--TSRVGTCLYASPEQLEG---SEYDAKSDMYSLGVVLLEL-FQPFG 528 D T K P+ T VGT LY SPE ++G S Y+ K D++SLG++ E+ + P Sbjct: 884 DQTGDLIKSDPSGHLTGMVGTALYVSPE-VQGSTKSAYNQKVDLFSLGIIFFEMSYHPMV 942 Query: 529 TEMERAEVLTGLR---TGQLPESLRK-RCPVQAKYIQHLTRRNSSQRPSAIQLLQSEL 582 T ER VL LR + + PE Q I L + ++RP+A +LL+SEL Sbjct: 943 TASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSEL 1000 Score = 33.1 bits (74), Expect = 0.80 Identities = 41/185 (22%), Positives = 78/185 (42%), Gaps = 39/185 (21%) Query: 425 ELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLA--CTDILQKNTDWTNRNGK 482 +L+ G+ Y+H+ +VH+ L N+ + + VKI D+ ++ DI +++ Sbjct: 408 QLLSGLDYLHSNSVVHKVLSASNVLVDA-EGTVKITDYSISKRLADICKEDV-------- 458 Query: 483 RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRT 542 +RV A P + K D++ LG++LL L Q G Sbjct: 459 ---FEQTRVRFSDNALPYKT-----GKKGDVWRLGLLLLSLSQ-------------GQEC 497 Query: 543 GQLPESLRKRCPVQAK-YIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQE 601 G+ P ++ P + +++ + +R S QLL+ +N +M ++EQ Sbjct: 498 GEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSF------INPQPKMPLVEQS 551 Query: 602 KEIAE 606 E +E Sbjct: 552 PEDSE 556 >gi|134304838 eukaryotic translation initiation factor 2-alpha kinase 3 [Homo sapiens] Length = 1116 Score = 134 bits (338), Expect = 2e-31 Identities = 96/324 (29%), Positives = 151/324 (46%), Gaps = 32/324 (9%) Query: 271 NDESSSSSIIFAEPTPEKEKR--------FGESDTENQNNKSVKYTTNLVIRESGELEST 322 NDE S + +E +P R F +S +N ++K T L I + T Sbjct: 779 NDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLT 838 Query: 323 LELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHI 382 + + A+ + P + L ++ T + S V L+I Sbjct: 839 AFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKV------------YLYI 886 Query: 383 QMQLCEL-SLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHR 441 QMQLC +L DW+ GR ++E +V IF ++ E V ++H+ G++HR Sbjct: 887 QMQLCRKENLKDWM-----NGRCTIEERE-----RSVCLHIFLQIAEAVEFLHSKGLMHR 936 Query: 442 DLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQ 501 DLKP NIF D VK+GDFGL + HT +VGT LY SPEQ Sbjct: 937 DLKPSNIFFT-MDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQ 995 Query: 502 LEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQ 561 + G+ Y K D++SLG++L EL PF T+MER LT +R + P ++ P + +Q Sbjct: 996 IHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQ 1055 Query: 562 HLTRRNSSQRPSAIQLLQSELFQN 585 + + +RP AI ++++ +F++ Sbjct: 1056 DMLSPSPMERPEAINIIENAVFED 1079 Score = 74.7 bits (182), Expect = 2e-13 Identities = 37/75 (49%), Positives = 51/75 (68%), Gaps = 1/75 (1%) Query: 161 SRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAG 220 SRYL +FE + LG+GG+G V++ +NK+D YAIK+I + + KV+REVK LA Sbjct: 587 SRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPN-RELAREKVMREVKALAK 645 Query: 221 LQHPNIVGYHTAWIE 235 L+HP IV Y AW+E Sbjct: 646 LEHPGIVRYFNAWLE 660 >gi|208431829 eukaryotic translation initiation factor 2-alpha kinase 2 isoform b [Homo sapiens] Length = 510 Score = 106 bits (265), Expect = 6e-23 Identities = 92/325 (28%), Positives = 148/325 (45%), Gaps = 40/325 (12%) Query: 259 DQEEDREQCGVKNDESSSSSIIF--AEPTPEKEKRFGESDTENQNNKSVKYTTNLVIRES 316 D D + +D +SSS++ K KR + + K KYT + Sbjct: 207 DFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKYTVD------ 260 Query: 317 GELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQY 376 + E + LA L +IV + E+ + ESS+ + + Sbjct: 261 ---KRKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSK 317 Query: 377 HLMLHIQMQLCEL-SLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHN 435 L IQM+ C+ +L WI KR E +D+ +A ++F+++ +GV YIH+ Sbjct: 318 TKCLFIQMEFCDKGTLEQWI---EKRRGEKLDKV--------LALELFEQITKGVDYIHS 366 Query: 436 MGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCL 495 ++HRDLKP NIFL +QVKIGDFGL + +GKRT + GT Sbjct: 367 KKLIHRDLKPSNIFLVDT-KQVKIGDFGLVTS---------LKNDGKRTRSK----GTLR 412 Query: 496 YASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPV 555 Y SPEQ+ +Y + D+Y+LG++L EL T E ++ T LR G + + K+ Sbjct: 413 YMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKK--- 469 Query: 556 QAKYIQHLTRRNSSQRPSAIQLLQS 580 + +Q L + RP+ ++L++ Sbjct: 470 EKTLLQKLLSKKPEDRPNTSEILRT 494 Score = 30.0 bits (66), Expect = 6.7 Identities = 14/24 (58%), Positives = 15/24 (62%) Query: 210 KVLREVKVLAGLQHPNIVGYHTAW 233 K REVK LA L H NIV Y+ W Sbjct: 263 KAEREVKALAKLDHVNIVHYNGCW 286 >gi|208431827 eukaryotic translation initiation factor 2-alpha kinase 2 isoform a [Homo sapiens] Length = 551 Score = 103 bits (258), Expect = 4e-22 Identities = 75/230 (32%), Positives = 118/230 (51%), Gaps = 30/230 (13%) Query: 352 EESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCEL-SLWDWIVERNKRGREYVDESA 410 E S S E S + N + ++ L IQM+ C+ +L WI KR E +D+ Sbjct: 335 ETSDDSLESSDYDPENSKNSSRSKTKC-LFIQMEFCDKGTLEQWI---EKRRGEKLDKV- 389 Query: 411 CPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDIL 470 +A ++F+++ +GV YIH+ ++HRDLKP NIFL +QVKIGDFGL + Sbjct: 390 -------LALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDT-KQVKIGDFGLVTS--- 438 Query: 471 QKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTE 530 +GKRT + GT Y SPEQ+ +Y + D+Y+LG++L EL T Sbjct: 439 ------LKNDGKRTRSK----GTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTA 488 Query: 531 MERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQS 580 E ++ T LR G + + K+ + +Q L + RP+ ++L++ Sbjct: 489 FETSKFFTDLRDGIISDIFDKK---EKTLLQKLLSKKPEDRPNTSEILRT 535 Score = 60.5 bits (145), Expect = 5e-09 Identities = 28/72 (38%), Positives = 45/72 (62%), Gaps = 6/72 (8%) Query: 162 RYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGL 221 R+ +F+E+ ++G GG+G+V+K ++++DG+ Y IK++ K REVK LA L Sbjct: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNE------KAEREVKALAKL 315 Query: 222 QHPNIVGYHTAW 233 H NIV Y+ W Sbjct: 316 DHVNIVHYNGCW 327 >gi|4506103 eukaryotic translation initiation factor 2-alpha kinase 2 isoform a [Homo sapiens] Length = 551 Score = 103 bits (258), Expect = 4e-22 Identities = 75/230 (32%), Positives = 118/230 (51%), Gaps = 30/230 (13%) Query: 352 EESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCEL-SLWDWIVERNKRGREYVDESA 410 E S S E S + N + ++ L IQM+ C+ +L WI KR E +D+ Sbjct: 335 ETSDDSLESSDYDPENSKNSSRSKTKC-LFIQMEFCDKGTLEQWI---EKRRGEKLDKV- 389 Query: 411 CPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDIL 470 +A ++F+++ +GV YIH+ ++HRDLKP NIFL +QVKIGDFGL + Sbjct: 390 -------LALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDT-KQVKIGDFGLVTS--- 438 Query: 471 QKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTE 530 +GKRT + GT Y SPEQ+ +Y + D+Y+LG++L EL T Sbjct: 439 ------LKNDGKRTRSK----GTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTA 488 Query: 531 MERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQS 580 E ++ T LR G + + K+ + +Q L + RP+ ++L++ Sbjct: 489 FETSKFFTDLRDGIISDIFDKK---EKTLLQKLLSKKPEDRPNTSEILRT 535 Score = 60.5 bits (145), Expect = 5e-09 Identities = 28/72 (38%), Positives = 45/72 (62%), Gaps = 6/72 (8%) Query: 162 RYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGL 221 R+ +F+E+ ++G GG+G+V+K ++++DG+ Y IK++ K REVK LA L Sbjct: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNE------KAEREVKALAKL 315 Query: 222 QHPNIVGYHTAW 233 H NIV Y+ W Sbjct: 316 DHVNIVHYNGCW 327 >gi|4826878 oxidative-stress responsive 1 [Homo sapiens] Length = 527 Score = 81.3 bits (199), Expect = 3e-15 Identities = 75/246 (30%), Positives = 119/246 (48%), Gaps = 29/246 (11%) Query: 395 IVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPD 454 IV + + +DES +AT I +E++EG+ Y+H G +HRD+K NI L G D Sbjct: 107 IVAKGEHKSGVLDEST-------IAT-ILREVLEGLEYLHKNGQIHRDVKAGNILL-GED 157 Query: 455 QQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSE-YDAKSDM 513 V+I DFG++ L D T ++T VGT + +PE +E YD K+D+ Sbjct: 158 GSVQIADFGVSA--FLATGGDITRNKVRKT-----FVGTPCWMAPEVMEQVRGYDFKADI 210 Query: 514 YSLGVVLLEL---------FQPFGTEMERAE-VLTGLRTG-QLPESLRKRCPVQAKYIQH 562 +S G+ +EL + P M + L TG Q E L+K K I Sbjct: 211 WSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISL 270 Query: 563 LTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQEKEIAELKKQLNLLSQDKGVRD 622 +++ +RP+A +LL+ + FQ + N LQ K +++ I+E K++ + G Sbjct: 271 CLQKDPEKRPTAAELLRHKFFQKAKNKEF-LQEKTLQRAPTISERAKKVRRVPGSSGRLH 329 Query: 623 DGKDGG 628 +DGG Sbjct: 330 KTEDGG 335 Score = 33.9 bits (76), Expect = 0.47 Identities = 18/70 (25%), Positives = 39/70 (55%), Gaps = 1/70 (1%) Query: 165 NEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHP 224 +++E ++G G V + AIK+I ++ +T ++L+E++ ++ HP Sbjct: 15 DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKC-QTSMDELLKEIQAMSQCHHP 73 Query: 225 NIVGYHTAWI 234 NIV Y+T+++ Sbjct: 74 NIVSYYTSFV 83 >gi|4505373 NIMA-related kinase 2 [Homo sapiens] Length = 445 Score = 80.5 bits (197), Expect = 4e-15 Identities = 65/207 (31%), Positives = 98/207 (47%), Gaps = 22/207 (10%) Query: 380 LHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANV--ATKIFQELVEGVFYIHNMG 437 L+I M+ CE ++ + + R+Y+DE VM + A K +G Sbjct: 82 LYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDG-----GHT 136 Query: 438 IVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYA 497 ++HRDLKP N+FL G Q VK+GDFGLA IL +T + + VGT Y Sbjct: 137 VLHRDLKPANVFLDGK-QNVKLGDFGLA--RILNHDTSFAK----------TFVGTPYYM 183 Query: 498 SPEQLEGSEYDAKSDMYSLGVVLLEL--FQPFGTEMERAEVLTGLRTGQLPESLRKRCPV 555 SPEQ+ Y+ KSD++SLG +L EL P T + E+ +R G+ + Sbjct: 184 SPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDE 243 Query: 556 QAKYIQHLTRRNSSQRPSAIQLLQSEL 582 + I + RPS ++L++ L Sbjct: 244 LNEIITRMLNLKDYHRPSVEEILENPL 270 Score = 49.7 bits (117), Expect = 8e-06 Identities = 25/73 (34%), Positives = 40/73 (54%) Query: 166 EFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPN 225 ++E L +G G YGR K+R K DG+ K++ T+ ++ EV +L L+HPN Sbjct: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66 Query: 226 IVGYHTAWIEHVH 238 IV Y+ I+ + Sbjct: 67 IVRYYDRIIDRTN 79 >gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog, yeast) [Homo sapiens] Length = 545 Score = 79.3 bits (194), Expect = 1e-14 Identities = 70/251 (27%), Positives = 121/251 (48%), Gaps = 29/251 (11%) Query: 389 LSLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNI 448 L + +IV R + ++E+ + I +E++EG+ Y+H G +HRDLK NI Sbjct: 147 LDIIKYIVNRGEHKNGVLEEA--------IIATILKEVLEGLDYLHRNGQIHRDLKAGNI 198 Query: 449 FLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSE-Y 507 L G D V+I DFG++ L D T ++T VGT + +PE +E Y Sbjct: 199 LL-GEDGSVQIADFGVSA--FLATGGDVTRNKVRKT-----FVGTPCWMAPEVMEQVRGY 250 Query: 508 DAKSDMYSLGVVLLEL---------FQPFGTEMERAE-VLTGLRTG-QLPESLRKRCPVQ 556 D K+DM+S G+ +EL + P M + L TG + E ++K Sbjct: 251 DFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSF 310 Query: 557 AKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQEKEIAELKKQLNLLSQ 616 K + +++ S+RP+A +LL+ + FQ + N ++ K++ + +IA+ K++ + Sbjct: 311 RKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIE-KLLTRTPDIAQRAKKVRRVPG 369 Query: 617 DKGVRDDGKDG 627 G +DG Sbjct: 370 SSGHLHKTEDG 380 Score = 33.5 bits (75), Expect = 0.61 Identities = 18/68 (26%), Positives = 38/68 (55%), Gaps = 1/68 (1%) Query: 167 FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNI 226 +E ++G G V K + AIK+I ++ +T ++L+E++ ++ HPN+ Sbjct: 63 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKC-QTSMDELLKEIQAMSQCSHPNV 121 Query: 227 VGYHTAWI 234 V Y+T+++ Sbjct: 122 VTYYTSFV 129 >gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens] Length = 470 Score = 76.3 bits (186), Expect = 8e-14 Identities = 64/194 (32%), Positives = 99/194 (51%), Gaps = 24/194 (12%) Query: 423 FQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGK 482 F +L+ GV Y+H I+HRDLK +N+FL + +KIGDFG++ +L + D Sbjct: 139 FIQLLLGVDYMHERRILHRDLKSKNVFLK--NNLLKIGDFGVS--RLLMGSCDLA----- 189 Query: 483 RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLEL--FQPFGTEMERAEVLTGL 540 T+ GT Y SPE L+ YD KSD++SL +L E+ ++ + Sbjct: 190 -----TTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKI 244 Query: 541 RTGQLPESLRKRCPVQAKYI-QHLTRRNSSQRPSAIQLLQ----SELFQN--SGNVNLTL 593 G P SL +R P + I + + +N S RPSAI++L+ E QN +TL Sbjct: 245 VEGDTP-SLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTL 303 Query: 594 QMKIIEQEKEIAEL 607 + K ++ +KE A + Sbjct: 304 EDKNLDCQKEAAHI 317 Score = 34.3 bits (77), Expect = 0.36 Identities = 19/66 (28%), Positives = 34/66 (51%), Gaps = 3/66 (4%) Query: 173 LGKGGYGRVYKVRNKL---DGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGY 229 LG G +G VY V +K + +K+I + ++ E ++L+ L HP IV + Sbjct: 35 LGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKF 94 Query: 230 HTAWIE 235 H +++E Sbjct: 95 HASFVE 100 >gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens] Length = 599 Score = 76.3 bits (186), Expect = 8e-14 Identities = 64/194 (32%), Positives = 99/194 (51%), Gaps = 24/194 (12%) Query: 423 FQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGK 482 F +L+ GV Y+H I+HRDLK +N+FL + +KIGDFG++ +L + D Sbjct: 139 FIQLLLGVDYMHERRILHRDLKSKNVFLK--NNLLKIGDFGVS--RLLMGSCDLA----- 189 Query: 483 RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLEL--FQPFGTEMERAEVLTGL 540 T+ GT Y SPE L+ YD KSD++SL +L E+ ++ + Sbjct: 190 -----TTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKI 244 Query: 541 RTGQLPESLRKRCPVQAKYI-QHLTRRNSSQRPSAIQLLQ----SELFQN--SGNVNLTL 593 G P SL +R P + I + + +N S RPSAI++L+ E QN +TL Sbjct: 245 VEGDTP-SLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTL 303 Query: 594 QMKIIEQEKEIAEL 607 + K ++ +KE A + Sbjct: 304 EDKNLDCQKEAAHI 317 Score = 34.3 bits (77), Expect = 0.36 Identities = 19/66 (28%), Positives = 34/66 (51%), Gaps = 3/66 (4%) Query: 173 LGKGGYGRVYKVRNKL---DGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGY 229 LG G +G VY V +K + +K+I + ++ E ++L+ L HP IV + Sbjct: 35 LGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKF 94 Query: 230 HTAWIE 235 H +++E Sbjct: 95 HASFVE 100 >gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens] Length = 645 Score = 76.3 bits (186), Expect = 8e-14 Identities = 64/194 (32%), Positives = 99/194 (51%), Gaps = 24/194 (12%) Query: 423 FQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGK 482 F +L+ GV Y+H I+HRDLK +N+FL + +KIGDFG++ +L + D Sbjct: 139 FIQLLLGVDYMHERRILHRDLKSKNVFLK--NNLLKIGDFGVS--RLLMGSCDLA----- 189 Query: 483 RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLEL--FQPFGTEMERAEVLTGL 540 T+ GT Y SPE L+ YD KSD++SL +L E+ ++ + Sbjct: 190 -----TTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKI 244 Query: 541 RTGQLPESLRKRCPVQAKYI-QHLTRRNSSQRPSAIQLLQ----SELFQN--SGNVNLTL 593 G P SL +R P + I + + +N S RPSAI++L+ E QN +TL Sbjct: 245 VEGDTP-SLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTL 303 Query: 594 QMKIIEQEKEIAEL 607 + K ++ +KE A + Sbjct: 304 EDKNLDCQKEAAHI 317 Score = 34.3 bits (77), Expect = 0.36 Identities = 19/66 (28%), Positives = 34/66 (51%), Gaps = 3/66 (4%) Query: 173 LGKGGYGRVYKVRNKL---DGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGY 229 LG G +G VY V +K + +K+I + ++ E ++L+ L HP IV + Sbjct: 35 LGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKF 94 Query: 230 HTAWIE 235 H +++E Sbjct: 95 HASFVE 100 >gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] Length = 431 Score = 75.5 bits (184), Expect = 1e-13 Identities = 74/286 (25%), Positives = 133/286 (46%), Gaps = 32/286 (11%) Query: 351 LEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDE-S 409 LEE+ E+ +E + L Q ++ Y + + L + LW I+ G +D Sbjct: 57 LEEAEDEIEDIQQE-ITVLSQCDSPY-VTKYYGSYLKDTKLW--IIMEYLGGGSALDLLE 112 Query: 410 ACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFL--HGPDQQVKIGDFGLACT 467 P +AT I +E+++G+ Y+H+ +HRD+K N+ L HG +VK+ DFG+A Sbjct: 113 PGPLDETQIAT-ILREILKGLDYLHSEKKIHRDIKAANVLLSEHG---EVKLADFGVA-- 166 Query: 468 DILQKNTDWTNRNGKRTPTHTSR---VGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF 524 G+ T T R VGT + +PE ++ S YD+K+D++SLG+ +EL Sbjct: 167 -------------GQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELA 213 Query: 525 --QPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSEL 582 +P +E+ +VL + P ++++ + S RP+A +LL+ + Sbjct: 214 RGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 273 Query: 583 FQNSGNVNLTLQMKIIEQEKEIAELKKQLNLLSQDKGVRDDGKDGG 628 + L ++I++ K + + S+D DG+ G Sbjct: 274 ILRNAKKTSYL-TELIDRYKRWKAEQSHDDSSSEDSDAETDGQASG 318 Score = 30.8 bits (68), Expect = 3.9 Identities = 18/69 (26%), Positives = 37/69 (53%), Gaps = 1/69 (1%) Query: 167 FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNI 226 F +L +GKG +G V+K + + AIK I ++ A + + +E+ VL+ P + Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYV 82 Query: 227 VGYHTAWIE 235 Y+ ++++ Sbjct: 83 TKYYGSYLK 91 >gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] Length = 443 Score = 75.5 bits (184), Expect = 1e-13 Identities = 74/286 (25%), Positives = 133/286 (46%), Gaps = 32/286 (11%) Query: 351 LEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDE-S 409 LEE+ E+ +E + L Q ++ Y + + L + LW I+ G +D Sbjct: 69 LEEAEDEIEDIQQE-ITVLSQCDSPY-VTKYYGSYLKDTKLW--IIMEYLGGGSALDLLE 124 Query: 410 ACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFL--HGPDQQVKIGDFGLACT 467 P +AT I +E+++G+ Y+H+ +HRD+K N+ L HG +VK+ DFG+A Sbjct: 125 PGPLDETQIAT-ILREILKGLDYLHSEKKIHRDIKAANVLLSEHG---EVKLADFGVA-- 178 Query: 468 DILQKNTDWTNRNGKRTPTHTSR---VGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF 524 G+ T T R VGT + +PE ++ S YD+K+D++SLG+ +EL Sbjct: 179 -------------GQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELA 225 Query: 525 --QPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSEL 582 +P +E+ +VL + P ++++ + S RP+A +LL+ + Sbjct: 226 RGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 285 Query: 583 FQNSGNVNLTLQMKIIEQEKEIAELKKQLNLLSQDKGVRDDGKDGG 628 + L ++I++ K + + S+D DG+ G Sbjct: 286 ILRNAKKTSYL-TELIDRYKRWKAEQSHDDSSSEDSDAETDGQASG 330 Score = 30.8 bits (68), Expect = 3.9 Identities = 18/69 (26%), Positives = 37/69 (53%), Gaps = 1/69 (1%) Query: 167 FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNI 226 F +L +GKG +G V+K + + AIK I ++ A + + +E+ VL+ P + Sbjct: 36 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYV 94 Query: 227 VGYHTAWIE 235 Y+ ++++ Sbjct: 95 TKYYGSYLK 103 >gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sapiens] Length = 1328 Score = 75.5 bits (184), Expect = 1e-13 Identities = 52/173 (30%), Positives = 84/173 (48%), Gaps = 11/173 (6%) Query: 418 VATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWT 477 V K +++++GV Y+H +VHRD+K N+ L P +K+ DFG A + W Sbjct: 1162 VFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLM-PTGIIKLIDFGCA------RRLAWA 1214 Query: 478 NRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF--QPFGTEMER-- 533 NG + S GT + +PE + S Y KSD++S+G + E+ +P M+R Sbjct: 1215 GLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMA 1274 Query: 534 AEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNS 586 A G G +P A +++ R+ +RPSA+QLL+ + S Sbjct: 1275 AMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLERS 1327 Score = 39.3 bits (90), Expect = 0.011 Identities = 25/62 (40%), Positives = 32/62 (51%), Gaps = 5/62 (8%) Query: 172 ILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLR----EVKVLAGLQHPNIV 227 ILGKG YG VY GQ A+K++ + + K K R EV +L L+H NIV Sbjct: 1066 ILGKGAYGTVYCGLTS-QGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 1124 Query: 228 GY 229 Y Sbjct: 1125 AY 1126 >gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sapiens] Length = 510 Score = 75.5 bits (184), Expect = 1e-13 Identities = 52/173 (30%), Positives = 84/173 (48%), Gaps = 11/173 (6%) Query: 418 VATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWT 477 V K +++++GV Y+H +VHRD+K N+ L P +K+ DFG A + W Sbjct: 344 VFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLM-PTGIIKLIDFGCA------RRLAWA 396 Query: 478 NRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF--QPFGTEMER-- 533 NG + S GT + +PE + S Y KSD++S+G + E+ +P M+R Sbjct: 397 GLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMA 456 Query: 534 AEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNS 586 A G G +P A +++ R+ +RPSA+QLL+ + S Sbjct: 457 AMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLERS 509 Score = 39.3 bits (90), Expect = 0.011 Identities = 25/62 (40%), Positives = 32/62 (51%), Gaps = 5/62 (8%) Query: 172 ILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLR----EVKVLAGLQHPNIV 227 ILGKG YG VY GQ A+K++ + + K K R EV +L L+H NIV Sbjct: 248 ILGKGAYGTVYCGLTS-QGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 306 Query: 228 GY 229 Y Sbjct: 307 AY 308 >gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinase 1 [Homo sapiens] Length = 671 Score = 74.3 bits (181), Expect = 3e-13 Identities = 64/273 (23%), Positives = 122/273 (44%), Gaps = 12/273 (4%) Query: 310 NLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEESSEENVNFL 369 N++ +S + + EL G +S Q L + + + + E+ E + Sbjct: 8 NVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMM 67 Query: 370 GQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEG 429 + ++ ++ + + E + ++E ++G A +V +I E++EG Sbjct: 68 NRL--RHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEG 125 Query: 430 VFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQK-NTDWTNRNGKRTPTHT 488 + Y+H G++H+DLKP NI + D +KI D GLA + K N + N + T Sbjct: 126 MCYLHGKGVIHKDLKPENILVDN-DFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAK 184 Query: 489 SRVGTCLYASPEQLE--GSEYDAKSDMYSLGVVLLELF---QPFGTEMERAEVLTGLRTG 543 GT Y +PE L ++ KSD+YS VVL +F +P+ + +++ +++G Sbjct: 185 KNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSG 244 Query: 544 QLP--ESLRKRCPVQAKYIQHLT-RRNSSQRPS 573 P + + + CP + + L N RP+ Sbjct: 245 NRPDVDDITEYCPREIISLMKLCWEANPEARPT 277 >gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens] Length = 2382 Score = 73.2 bits (178), Expect = 7e-13 Identities = 54/176 (30%), Positives = 83/176 (47%), Gaps = 21/176 (11%) Query: 424 QELVEGVFYIHNMG--IVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 481 +++++G+ ++H I+HRDLK NIF+ GP VKIGD GLA Sbjct: 329 RQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL-------------- 374 Query: 482 KRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF---QPFGTEMERAEVLT 538 KR S +GT + +PE E +YD D+Y+ G+ +LE+ P+ A++ Sbjct: 375 KRASFAKSVIGTPEFMAPEMYE-EKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYR 433 Query: 539 GLRTGQLPESLRK-RCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTL 593 + +G P S K P + I+ R+N +R S LL FQ V + L Sbjct: 434 RVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVEL 489 Score = 37.7 bits (86), Expect = 0.032 Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 5/104 (4%) Query: 130 SAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLD 189 SAKE +++ + I+++ ++ V + + R+L E+ G+G + VYK + Sbjct: 189 SAKEP-QEERSQQQDDIEELETKAVGM-SNDGRFLKFDIEI---GRGSFKTVYKGLDTET 243 Query: 190 GQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAW 233 A ++ + TK+ + E ++L GLQHPNIV ++ +W Sbjct: 244 TVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSW 287 >gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo sapiens] Length = 648 Score = 72.8 bits (177), Expect = 9e-13 Identities = 55/176 (31%), Positives = 86/176 (48%), Gaps = 22/176 (12%) Query: 422 IFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 481 I ++ +G+ Y+H I+HRD+K NIFLH VKIGDFGLA + W+ Sbjct: 448 IARQTAQGMDYLHAKNIIHRDMKSNNIFLH-EGLTVKIGDFGLATV-----KSRWSGSQQ 501 Query: 482 KRTPTHTSRVGTCLYASPEQL---EGSEYDAKSDMYSLGVVLLELFQ---PFGTEMERAE 535 PT G+ L+ +PE + + + + +SD+YS G+VL EL P+ R + Sbjct: 502 VEQPT-----GSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQ 556 Query: 536 VLTGLRTGQLP---ESLRKRCP-VQAKYIQHLTRRNSSQRPSAIQLLQS-ELFQNS 586 ++ + G L K CP + + ++ +RP Q+L S EL Q+S Sbjct: 557 IIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHS 612 >gi|33188459 B-Raf [Homo sapiens] Length = 766 Score = 71.6 bits (174), Expect = 2e-12 Identities = 53/169 (31%), Positives = 82/169 (48%), Gaps = 21/169 (12%) Query: 422 IFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 481 I ++ +G+ Y+H I+HRDLK NIFLH D VKIGDFGLA + W+ + Sbjct: 556 IARQTAQGMDYLHAKSIIHRDLKSNNIFLH-EDLTVKIGDFGLATV-----KSRWSGSH- 608 Query: 482 KRTPTHTSRVGTCLYASPEQL---EGSEYDAKSDMYSLGVVLLELFQ---PFGTEMERAE 535 G+ L+ +PE + + + Y +SD+Y+ G+VL EL P+ R + Sbjct: 609 ----QFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ 664 Query: 536 VLTGLRTGQLPESL---RKRCPVQAKYIQ-HLTRRNSSQRPSAIQLLQS 580 ++ + G L L R CP K + ++ +RP Q+L S Sbjct: 665 IIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILAS 713 >gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens] Length = 1243 Score = 71.2 bits (173), Expect = 3e-12 Identities = 57/204 (27%), Positives = 96/204 (47%), Gaps = 24/204 (11%) Query: 424 QELVEGVFYIHNM--GIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 481 ++++ G+ ++H+ I+HRDLK N+F+ GP VKIGD GLA Sbjct: 282 RQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATL-------------- 327 Query: 482 KRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF---QPFGTEMERAEVLT 538 KR S +GT + +PE E +YD D+Y+ G+ +LE+ P+ A++ Sbjct: 328 KRASFAKSVIGTPEFMAPEMYE-EKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYR 386 Query: 539 GLRTGQLPESLRK-RCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKI 597 + +G+ P S K + P + I+ R + ++R + LL F+ V++ L Sbjct: 387 KVTSGRKPNSFHKVKIPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREERGVHVELAE-- 444 Query: 598 IEQEKEIAELKKQLNLLSQDKGVR 621 E + E LK L + +G R Sbjct: 445 -EDDGEKPGLKLWLRMEDARRGGR 467 Score = 34.7 bits (78), Expect = 0.27 Identities = 17/61 (27%), Positives = 33/61 (54%) Query: 173 LGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTA 232 +G+G + VY+ + A ++ + ++ + EV++L GLQHPNIV ++ + Sbjct: 180 IGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDS 239 Query: 233 W 233 W Sbjct: 240 W 240 >gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo sapiens] Length = 416 Score = 71.2 bits (173), Expect = 3e-12 Identities = 67/245 (27%), Positives = 117/245 (47%), Gaps = 27/245 (11%) Query: 341 QQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNK 400 QQ+ + LEE+ E+ +E + L Q ++ Y + + L LW I+ Sbjct: 47 QQVVAIKIIDLEEAEDEIEDIQQE-ITVLSQCDSSY-VTKYYGSYLKGSKLW--IIMEYL 102 Query: 401 RGREYVDE-SACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKI 459 G +D A P+ +AT + +E+++G+ Y+H+ +HRD+K N+ L VK+ Sbjct: 103 GGGSALDLLRAGPFDEFQIATML-KEILKGLDYLHSEKKIHRDIKAANVLL-SEQGDVKL 160 Query: 460 GDFGLACTDILQKNTDWTNRNGKRTPTHTSR---VGTCLYASPEQLEGSEYDAKSDMYSL 516 DFG+A G+ T T R VGT + +PE ++ S YD+K+D++SL Sbjct: 161 ADFGVA---------------GQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSL 205 Query: 517 GVVLLELF--QPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSA 574 G+ +EL +P ++M VL + P + ++I ++ S RP+A Sbjct: 206 GITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTA 265 Query: 575 IQLLQ 579 +LL+ Sbjct: 266 KELLK 270 >gi|50845418 WNK lysine deficient protein kinase 3 isoform 1 [Homo sapiens] Length = 1800 Score = 70.5 bits (171), Expect = 4e-12 Identities = 53/176 (30%), Positives = 82/176 (46%), Gaps = 21/176 (11%) Query: 424 QELVEGVFYIHNMG--IVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 481 +++++G+ ++H I+HRDLK NIF+ GP VKIGD GLA Sbjct: 255 RQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL-------------- 300 Query: 482 KRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF---QPFGTEMERAEVLT 538 RT S +GT + +PE E YD D+Y+ G+ +LE+ P+ A++ Sbjct: 301 MRTSFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYR 359 Query: 539 GLRTGQLPESLRKRCPVQAK-YIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTL 593 + +G P S K + K I+ R+N S+R S LL F + + L Sbjct: 360 KVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVEL 415 Score = 37.7 bits (86), Expect = 0.032 Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 1/88 (1%) Query: 147 QKIRSREVALEAQTSRYLNEFEELAI-LGKGGYGRVYKVRNKLDGQYYAIKKILIKGATK 205 +K E ++A + F + I LG+G + VYK + A ++ + TK Sbjct: 126 EKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTK 185 Query: 206 TVCMKVLREVKVLAGLQHPNIVGYHTAW 233 + E ++L GLQHPNIV ++ +W Sbjct: 186 AEQQRFKEEAEMLKGLQHPNIVRFYDSW 213 >gi|50845416 WNK lysine deficient protein kinase 3 isoform 2 [Homo sapiens] Length = 1743 Score = 70.5 bits (171), Expect = 4e-12 Identities = 53/176 (30%), Positives = 82/176 (46%), Gaps = 21/176 (11%) Query: 424 QELVEGVFYIHNMG--IVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 481 +++++G+ ++H I+HRDLK NIF+ GP VKIGD GLA Sbjct: 255 RQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL-------------- 300 Query: 482 KRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF---QPFGTEMERAEVLT 538 RT S +GT + +PE E YD D+Y+ G+ +LE+ P+ A++ Sbjct: 301 MRTSFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYR 359 Query: 539 GLRTGQLPESLRKRCPVQAK-YIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTL 593 + +G P S K + K I+ R+N S+R S LL F + + L Sbjct: 360 KVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVEL 415 Score = 37.7 bits (86), Expect = 0.032 Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 1/88 (1%) Query: 147 QKIRSREVALEAQTSRYLNEFEELAI-LGKGGYGRVYKVRNKLDGQYYAIKKILIKGATK 205 +K E ++A + F + I LG+G + VYK + A ++ + TK Sbjct: 126 EKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTK 185 Query: 206 TVCMKVLREVKVLAGLQHPNIVGYHTAW 233 + E ++L GLQHPNIV ++ +W Sbjct: 186 AEQQRFKEEAEMLKGLQHPNIVRFYDSW 213 >gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Homo sapiens] Length = 339 Score = 70.5 bits (171), Expect = 4e-12 Identities = 55/192 (28%), Positives = 95/192 (49%), Gaps = 23/192 (11%) Query: 394 WIVERNKRGREYVDE-SACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHG 452 WI+ G +D A P+ +AT + +E+++G+ Y+H+ +HRD+K N+ L Sbjct: 19 WIIMEYLGGGSALDLLRAGPFDEFQIATML-KEILKGLDYLHSEKKIHRDIKAANVLL-S 76 Query: 453 PDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSR---VGTCLYASPEQLEGSEYDA 509 VK+ DFG+A G+ T T R VGT + +PE ++ S YD+ Sbjct: 77 EQGDVKLADFGVA---------------GQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDS 121 Query: 510 KSDMYSLGVVLLELF--QPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRN 567 K+D++SLG+ +EL +P ++M VL + P + ++I ++ Sbjct: 122 KADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKD 181 Query: 568 SSQRPSAIQLLQ 579 S RP+A +LL+ Sbjct: 182 PSFRPTAKELLK 193 >gi|156105707 SNF related kinase [Homo sapiens] Length = 765 Score = 69.3 bits (168), Expect = 1e-11 Identities = 52/162 (32%), Positives = 81/162 (50%), Gaps = 21/162 (12%) Query: 417 NVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDW 476 ++A K F ++V + Y H + +VHRDLKP N+ VK+ DFG + Sbjct: 114 DLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSN---------- 163 Query: 477 TNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKS-DMYSLGVVLLELF--QPFGTEMER 533 + GK+ T+ G+ Y++PE L G EYDA + D++SLGV+L L QP E Sbjct: 164 KFQPGKKL---TTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEAND 220 Query: 534 AEVLTGLRTGQ--LPESLRKRCPVQAKYIQHLTRRNSSQRPS 573 +E LT + + +P + K C I + +R+ +R S Sbjct: 221 SETLTMIMDCKYTVPSHVSKEC---KDLITRMLQRDPKRRAS 259 >gi|156105705 SNF related kinase [Homo sapiens] Length = 765 Score = 69.3 bits (168), Expect = 1e-11 Identities = 52/162 (32%), Positives = 81/162 (50%), Gaps = 21/162 (12%) Query: 417 NVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDW 476 ++A K F ++V + Y H + +VHRDLKP N+ VK+ DFG + Sbjct: 114 DLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSN---------- 163 Query: 477 TNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKS-DMYSLGVVLLELF--QPFGTEMER 533 + GK+ T+ G+ Y++PE L G EYDA + D++SLGV+L L QP E Sbjct: 164 KFQPGKKL---TTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEAND 220 Query: 534 AEVLTGLRTGQ--LPESLRKRCPVQAKYIQHLTRRNSSQRPS 573 +E LT + + +P + K C I + +R+ +R S Sbjct: 221 SETLTMIMDCKYTVPSHVSKEC---KDLITRMLQRDPKRRAS 259 >gi|21359873 polo-like kinase 1 [Homo sapiens] Length = 603 Score = 68.9 bits (167), Expect = 1e-11 Identities = 59/193 (30%), Positives = 93/193 (48%), Gaps = 29/193 (15%) Query: 395 IVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPD 454 ++E +KR + + A Y+ +++V G Y+H ++HRDLK N+FL+ D Sbjct: 138 LLELHKRRKALTEPEARYYL---------RQIVLGCQYLHRNRVIHRDLKLGNLFLN-ED 187 Query: 455 QQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMY 514 +VKIGDFGLA +G+R T GT Y +PE L + + D++ Sbjct: 188 LEVKIGDFGLATK---------VEYDGERKKT---LCGTPNYIAPEVLSKKGHSFEVDVW 235 Query: 515 SLGVVLLELF---QPFGTEMERAEVLTGLRTGQLPESLRKRC-PVQAKYIQHLTRRNSSQ 570 S+G ++ L PF T + T LR + S+ K PV A IQ + + + + Sbjct: 236 SIGCIMYTLLVGKPPFETSCLKE---TYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTA 292 Query: 571 RPSAIQLLQSELF 583 RP+ +LL E F Sbjct: 293 RPTINELLNDEFF 305 Score = 29.6 bits (65), Expect = 8.8 Identities = 16/62 (25%), Positives = 33/62 (53%), Gaps = 7/62 (11%) Query: 173 LGKGGYGRVYKVRNKLDGQYYA----IKKILIKGATKTVCMKVLREVKVLAGLQHPNIVG 228 LGKGG+ + +++ + + +A K +L+K + K+ E+ + L H ++VG Sbjct: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQRE---KMSMEISIHRSLAHQHVVG 115 Query: 229 YH 230 +H Sbjct: 116 FH 117 >gi|21361358 serine/threonine kinase 25 [Homo sapiens] Length = 426 Score = 68.6 bits (166), Expect = 2e-11 Identities = 67/285 (23%), Positives = 125/285 (43%), Gaps = 26/285 (9%) Query: 351 LEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESA 410 LEE+ E+ +E + L Q ++ Y + + L LW I+ G +D Sbjct: 53 LEEAEDEIEDIQQE-ITVLSQCDSPY-ITRYFGSYLKSTKLW--IIMEYLGGGSALDLLK 108 Query: 411 CPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDIL 470 + I +E+++G+ Y+H+ +HRD+K N+ L VK+ DFG+A Sbjct: 109 PGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLL-SEQGDVKLADFGVA----- 162 Query: 471 QKNTDWTNRNGKRTPTHTSR---VGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF--Q 525 G+ T T R VGT + +PE ++ S YD K+D++SLG+ +EL + Sbjct: 163 ----------GQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGE 212 Query: 526 PFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQN 585 P +++ VL + P + ++++ ++ RP+A +LL+ + F Sbjct: 213 PPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHK-FIT 271 Query: 586 SGNVNLTLQMKIIEQEKEIAELKKQLNLLSQDKGVRDDGKDGGVG 630 + ++I++ K S+D + + +DG G Sbjct: 272 RYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSDIDGEAEDGEQG 316 Score = 31.2 bits (69), Expect = 3.0 Identities = 20/69 (28%), Positives = 36/69 (52%), Gaps = 1/69 (1%) Query: 167 FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNI 226 F +L +GKG +G VYK + + AIK I ++ A + + +E+ VL+ P I Sbjct: 20 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYI 78 Query: 227 VGYHTAWIE 235 Y ++++ Sbjct: 79 TRYFGSYLK 87 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.315 0.133 0.378 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 24,337,978 Number of Sequences: 37866 Number of extensions: 1126388 Number of successful extensions: 6185 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 541 Number of HSP's successfully gapped in prelim test: 268 Number of HSP's that attempted gapping in prelim test: 4058 Number of HSP's gapped (non-prelim): 1630 length of query: 630 length of database: 18,247,518 effective HSP length: 108 effective length of query: 522 effective length of database: 14,157,990 effective search space: 7390470780 effective search space used: 7390470780 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.