Guide to the Human Genome
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Search of human proteins with 11125768

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11125768 eukaryotic translation initiation factor 2-alpha
kinase 1 isoform a [Homo sapiens]
         (630 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|11125768 eukaryotic translation initiation factor 2-alpha kin...  1254   0.0  
gi|197245437 eukaryotic translation initiation factor 2-alpha ki...  1248   0.0  
gi|65287717 eukaryotic translation initiation factor 2 alpha kin...   167   4e-41
gi|134304838 eukaryotic translation initiation factor 2-alpha ki...   134   2e-31
gi|208431829 eukaryotic translation initiation factor 2-alpha ki...   106   6e-23
gi|208431827 eukaryotic translation initiation factor 2-alpha ki...   103   4e-22
gi|4506103 eukaryotic translation initiation factor 2-alpha kina...   103   4e-22
gi|4826878 oxidative-stress responsive 1 [Homo sapiens]                81   3e-15
gi|4505373 NIMA-related kinase 2 [Homo sapiens]                        80   4e-15
gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog, yea...    79   1e-14
gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]            76   8e-14
gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]           76   8e-14
gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]           76   8e-14
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]       75   1e-13
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]        75   1e-13
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa...    75   1e-13
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa...    75   1e-13
gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinas...    74   3e-13
gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens]      73   7e-13
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom...    73   9e-13
gi|33188459 B-Raf [Homo sapiens]                                       72   2e-12
gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]       71   3e-12
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo...    71   3e-12
gi|50845418 WNK lysine deficient protein kinase 3 isoform 1 [Hom...    70   4e-12
gi|50845416 WNK lysine deficient protein kinase 3 isoform 2 [Hom...    70   4e-12
gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Hom...    70   4e-12
gi|156105707 SNF related kinase [Homo sapiens]                         69   1e-11
gi|156105705 SNF related kinase [Homo sapiens]                         69   1e-11
gi|21359873 polo-like kinase 1 [Homo sapiens]                          69   1e-11
gi|21361358 serine/threonine kinase 25 [Homo sapiens]                  69   2e-11

>gi|11125768 eukaryotic translation initiation factor 2-alpha kinase
           1 isoform a [Homo sapiens]
          Length = 630

 Score = 1254 bits (3246), Expect = 0.0
 Identities = 630/630 (100%), Positives = 630/630 (100%)

Query: 1   MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP 60
           MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP
Sbjct: 1   MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP 60

Query: 61  FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH 120
           FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH
Sbjct: 61  FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH 120

Query: 121 NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR 180
           NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR
Sbjct: 121 NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR 180

Query: 181 VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI 240
           VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI
Sbjct: 181 VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI 240

Query: 241 QPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ 300
           QPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ
Sbjct: 241 QPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ 300

Query: 301 NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE 360
           NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE
Sbjct: 301 NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE 360

Query: 361 SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT 420
           SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT
Sbjct: 361 SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT 420

Query: 421 KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN 480
           KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN
Sbjct: 421 KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN 480

Query: 481 GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL 540
           GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL
Sbjct: 481 GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL 540

Query: 541 RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ 600
           RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ
Sbjct: 541 RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ 600

Query: 601 EKEIAELKKQLNLLSQDKGVRDDGKDGGVG 630
           EKEIAELKKQLNLLSQDKGVRDDGKDGGVG
Sbjct: 601 EKEIAELKKQLNLLSQDKGVRDDGKDGGVG 630


>gi|197245437 eukaryotic translation initiation factor 2-alpha
           kinase 1 isoform b [Homo sapiens]
          Length = 629

 Score = 1248 bits (3230), Expect = 0.0
 Identities = 629/630 (99%), Positives = 629/630 (99%), Gaps = 1/630 (0%)

Query: 1   MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP 60
           MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP
Sbjct: 1   MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP 60

Query: 61  FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH 120
           FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH
Sbjct: 61  FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH 120

Query: 121 NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR 180
           NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR
Sbjct: 121 NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR 180

Query: 181 VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI 240
           VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI
Sbjct: 181 VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI 240

Query: 241 QPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ 300
           QPR DRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ
Sbjct: 241 QPR-DRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ 299

Query: 301 NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE 360
           NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE
Sbjct: 300 NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE 359

Query: 361 SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT 420
           SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT
Sbjct: 360 SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT 419

Query: 421 KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN 480
           KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN
Sbjct: 420 KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN 479

Query: 481 GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL 540
           GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL
Sbjct: 480 GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL 539

Query: 541 RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ 600
           RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ
Sbjct: 540 RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ 599

Query: 601 EKEIAELKKQLNLLSQDKGVRDDGKDGGVG 630
           EKEIAELKKQLNLLSQDKGVRDDGKDGGVG
Sbjct: 600 EKEIAELKKQLNLLSQDKGVRDDGKDGGVG 629


>gi|65287717 eukaryotic translation initiation factor 2 alpha kinase 4
            [Homo sapiens]
          Length = 1649

 Score =  167 bits (422), Expect = 4e-41
 Identities = 157/478 (32%), Positives = 230/478 (48%), Gaps = 51/478 (10%)

Query: 129  RSAKERVRQDPCEDISRIQKIRSREVALEAQT--SRYLNEFEELAILGKGGYGRVYKVRN 186
            +S ++   QD  E +    ++ S     E Q   SRY  EFEEL +LGKG +G V KV+N
Sbjct: 550  QSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGAFGAVIKVQN 609

Query: 187  KLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVIQPRADR 246
            KLDG  YA+K+I I  A++    ++  EV +L+ L H NIV Y+ AWIE       R +R
Sbjct: 610  KLDGCCYAVKRIPINPASRQF-RRIKGEVTLLSRLHHENIVRYYNAWIE-------RHER 661

Query: 247  -AAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQNNKSV 305
             A    P  +     ++DR   G    ++     + A   P       E  T  + + S 
Sbjct: 662  PAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSASA 721

Query: 306  KYTTNLVIRESGELESTLELQENGLAGLS--ASSIVEQQLPLRRNSHLEESFTSTEESSE 363
            ++        S + E   E +  G+   S   +S  E  +         +S    E+ +E
Sbjct: 722  RFPA--TGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNE 779

Query: 364  ENVNFLGQ----TEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVA 419
            +N     +    TEA ++  L+IQM+ CE S            R+ +D+    Y      
Sbjct: 780  KNGCHESEPSVTTEAVHY--LYIQMEYCEKSTL----------RDTIDQGL--YRDTVRL 825

Query: 420  TKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDIL-----QKNT 474
             ++F+E+++G+ YIH  G++HRDLKP NIFL   D  VKIGDFGLA TD L      K  
Sbjct: 826  WRLFREILDGLAYIHEKGMIHRDLKPVNIFLDS-DDHVKIGDFGLA-TDHLAFSADSKQD 883

Query: 475  DWTNRNGKRTPTH--TSRVGTCLYASPEQLEG---SEYDAKSDMYSLGVVLLEL-FQPFG 528
            D T    K  P+   T  VGT LY SPE ++G   S Y+ K D++SLG++  E+ + P  
Sbjct: 884  DQTGDLIKSDPSGHLTGMVGTALYVSPE-VQGSTKSAYNQKVDLFSLGIIFFEMSYHPMV 942

Query: 529  TEMERAEVLTGLR---TGQLPESLRK-RCPVQAKYIQHLTRRNSSQRPSAIQLLQSEL 582
            T  ER  VL  LR   + + PE         Q   I  L   + ++RP+A +LL+SEL
Sbjct: 943  TASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSEL 1000



 Score = 33.1 bits (74), Expect = 0.80
 Identities = 41/185 (22%), Positives = 78/185 (42%), Gaps = 39/185 (21%)

Query: 425 ELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLA--CTDILQKNTDWTNRNGK 482
           +L+ G+ Y+H+  +VH+ L   N+ +   +  VKI D+ ++    DI +++         
Sbjct: 408 QLLSGLDYLHSNSVVHKVLSASNVLVDA-EGTVKITDYSISKRLADICKEDV-------- 458

Query: 483 RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRT 542
                 +RV     A P +        K D++ LG++LL L Q             G   
Sbjct: 459 ---FEQTRVRFSDNALPYKT-----GKKGDVWRLGLLLLSLSQ-------------GQEC 497

Query: 543 GQLPESLRKRCPVQAK-YIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQE 601
           G+ P ++    P   + +++     +  +R S  QLL+         +N   +M ++EQ 
Sbjct: 498 GEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSF------INPQPKMPLVEQS 551

Query: 602 KEIAE 606
            E +E
Sbjct: 552 PEDSE 556


>gi|134304838 eukaryotic translation initiation factor 2-alpha kinase
            3 [Homo sapiens]
          Length = 1116

 Score =  134 bits (338), Expect = 2e-31
 Identities = 96/324 (29%), Positives = 151/324 (46%), Gaps = 32/324 (9%)

Query: 271  NDESSSSSIIFAEPTPEKEKR--------FGESDTENQNNKSVKYTTNLVIRESGELEST 322
            NDE  S  +  +E +P    R        F +S  +N ++K    T  L I      + T
Sbjct: 779  NDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLT 838

Query: 323  LELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHI 382
                 +  +   A+  +    P   +  L ++ T   + S   V             L+I
Sbjct: 839  AFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKV------------YLYI 886

Query: 383  QMQLCEL-SLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHR 441
            QMQLC   +L DW+      GR  ++E        +V   IF ++ E V ++H+ G++HR
Sbjct: 887  QMQLCRKENLKDWM-----NGRCTIEERE-----RSVCLHIFLQIAEAVEFLHSKGLMHR 936

Query: 442  DLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQ 501
            DLKP NIF    D  VK+GDFGL       +              HT +VGT LY SPEQ
Sbjct: 937  DLKPSNIFFT-MDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQ 995

Query: 502  LEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQ 561
            + G+ Y  K D++SLG++L EL  PF T+MER   LT +R  + P    ++ P +   +Q
Sbjct: 996  IHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQ 1055

Query: 562  HLTRRNSSQRPSAIQLLQSELFQN 585
             +   +  +RP AI ++++ +F++
Sbjct: 1056 DMLSPSPMERPEAINIIENAVFED 1079



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 37/75 (49%), Positives = 51/75 (68%), Gaps = 1/75 (1%)

Query: 161 SRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAG 220
           SRYL +FE +  LG+GG+G V++ +NK+D   YAIK+I +    +    KV+REVK LA 
Sbjct: 587 SRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPN-RELAREKVMREVKALAK 645

Query: 221 LQHPNIVGYHTAWIE 235
           L+HP IV Y  AW+E
Sbjct: 646 LEHPGIVRYFNAWLE 660


>gi|208431829 eukaryotic translation initiation factor 2-alpha
           kinase 2 isoform b [Homo sapiens]
          Length = 510

 Score =  106 bits (265), Expect = 6e-23
 Identities = 92/325 (28%), Positives = 148/325 (45%), Gaps = 40/325 (12%)

Query: 259 DQEEDREQCGVKNDESSSSSIIF--AEPTPEKEKRFGESDTENQNNKSVKYTTNLVIRES 316
           D   D  +    +D  +SSS++         K KR      +  + K  KYT +      
Sbjct: 207 DFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKYTVD------ 260

Query: 317 GELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQY 376
              +   E +   LA L   +IV          +  E+   + ESS+ +      +    
Sbjct: 261 ---KRKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSK 317

Query: 377 HLMLHIQMQLCEL-SLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHN 435
              L IQM+ C+  +L  WI    KR  E +D+         +A ++F+++ +GV YIH+
Sbjct: 318 TKCLFIQMEFCDKGTLEQWI---EKRRGEKLDKV--------LALELFEQITKGVDYIHS 366

Query: 436 MGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCL 495
             ++HRDLKP NIFL    +QVKIGDFGL  +            +GKRT +     GT  
Sbjct: 367 KKLIHRDLKPSNIFLVDT-KQVKIGDFGLVTS---------LKNDGKRTRSK----GTLR 412

Query: 496 YASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPV 555
           Y SPEQ+   +Y  + D+Y+LG++L EL     T  E ++  T LR G + +   K+   
Sbjct: 413 YMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKK--- 469

Query: 556 QAKYIQHLTRRNSSQRPSAIQLLQS 580
           +   +Q L  +    RP+  ++L++
Sbjct: 470 EKTLLQKLLSKKPEDRPNTSEILRT 494



 Score = 30.0 bits (66), Expect = 6.7
 Identities = 14/24 (58%), Positives = 15/24 (62%)

Query: 210 KVLREVKVLAGLQHPNIVGYHTAW 233
           K  REVK LA L H NIV Y+  W
Sbjct: 263 KAEREVKALAKLDHVNIVHYNGCW 286


>gi|208431827 eukaryotic translation initiation factor 2-alpha
           kinase 2 isoform a [Homo sapiens]
          Length = 551

 Score =  103 bits (258), Expect = 4e-22
 Identities = 75/230 (32%), Positives = 118/230 (51%), Gaps = 30/230 (13%)

Query: 352 EESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCEL-SLWDWIVERNKRGREYVDESA 410
           E S  S E S  +  N    + ++    L IQM+ C+  +L  WI    KR  E +D+  
Sbjct: 335 ETSDDSLESSDYDPENSKNSSRSKTKC-LFIQMEFCDKGTLEQWI---EKRRGEKLDKV- 389

Query: 411 CPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDIL 470
                  +A ++F+++ +GV YIH+  ++HRDLKP NIFL    +QVKIGDFGL  +   
Sbjct: 390 -------LALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDT-KQVKIGDFGLVTS--- 438

Query: 471 QKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTE 530
                    +GKRT +     GT  Y SPEQ+   +Y  + D+Y+LG++L EL     T 
Sbjct: 439 ------LKNDGKRTRSK----GTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTA 488

Query: 531 MERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQS 580
            E ++  T LR G + +   K+   +   +Q L  +    RP+  ++L++
Sbjct: 489 FETSKFFTDLRDGIISDIFDKK---EKTLLQKLLSKKPEDRPNTSEILRT 535



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 28/72 (38%), Positives = 45/72 (62%), Gaps = 6/72 (8%)

Query: 162 RYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGL 221
           R+  +F+E+ ++G GG+G+V+K ++++DG+ Y IK++           K  REVK LA L
Sbjct: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNE------KAEREVKALAKL 315

Query: 222 QHPNIVGYHTAW 233
            H NIV Y+  W
Sbjct: 316 DHVNIVHYNGCW 327


>gi|4506103 eukaryotic translation initiation factor 2-alpha kinase
           2 isoform a [Homo sapiens]
          Length = 551

 Score =  103 bits (258), Expect = 4e-22
 Identities = 75/230 (32%), Positives = 118/230 (51%), Gaps = 30/230 (13%)

Query: 352 EESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCEL-SLWDWIVERNKRGREYVDESA 410
           E S  S E S  +  N    + ++    L IQM+ C+  +L  WI    KR  E +D+  
Sbjct: 335 ETSDDSLESSDYDPENSKNSSRSKTKC-LFIQMEFCDKGTLEQWI---EKRRGEKLDKV- 389

Query: 411 CPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDIL 470
                  +A ++F+++ +GV YIH+  ++HRDLKP NIFL    +QVKIGDFGL  +   
Sbjct: 390 -------LALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDT-KQVKIGDFGLVTS--- 438

Query: 471 QKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTE 530
                    +GKRT +     GT  Y SPEQ+   +Y  + D+Y+LG++L EL     T 
Sbjct: 439 ------LKNDGKRTRSK----GTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTA 488

Query: 531 MERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQS 580
            E ++  T LR G + +   K+   +   +Q L  +    RP+  ++L++
Sbjct: 489 FETSKFFTDLRDGIISDIFDKK---EKTLLQKLLSKKPEDRPNTSEILRT 535



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 28/72 (38%), Positives = 45/72 (62%), Gaps = 6/72 (8%)

Query: 162 RYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGL 221
           R+  +F+E+ ++G GG+G+V+K ++++DG+ Y IK++           K  REVK LA L
Sbjct: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNE------KAEREVKALAKL 315

Query: 222 QHPNIVGYHTAW 233
            H NIV Y+  W
Sbjct: 316 DHVNIVHYNGCW 327


>gi|4826878 oxidative-stress responsive 1 [Homo sapiens]
          Length = 527

 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 75/246 (30%), Positives = 119/246 (48%), Gaps = 29/246 (11%)

Query: 395 IVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPD 454
           IV + +     +DES        +AT I +E++EG+ Y+H  G +HRD+K  NI L G D
Sbjct: 107 IVAKGEHKSGVLDEST-------IAT-ILREVLEGLEYLHKNGQIHRDVKAGNILL-GED 157

Query: 455 QQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSE-YDAKSDM 513
             V+I DFG++    L    D T    ++T      VGT  + +PE +E    YD K+D+
Sbjct: 158 GSVQIADFGVSA--FLATGGDITRNKVRKT-----FVGTPCWMAPEVMEQVRGYDFKADI 210

Query: 514 YSLGVVLLEL---------FQPFGTEMERAE-VLTGLRTG-QLPESLRKRCPVQAKYIQH 562
           +S G+  +EL         + P    M   +     L TG Q  E L+K      K I  
Sbjct: 211 WSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISL 270

Query: 563 LTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQEKEIAELKKQLNLLSQDKGVRD 622
             +++  +RP+A +LL+ + FQ + N    LQ K +++   I+E  K++  +    G   
Sbjct: 271 CLQKDPEKRPTAAELLRHKFFQKAKNKEF-LQEKTLQRAPTISERAKKVRRVPGSSGRLH 329

Query: 623 DGKDGG 628
             +DGG
Sbjct: 330 KTEDGG 335



 Score = 33.9 bits (76), Expect = 0.47
 Identities = 18/70 (25%), Positives = 39/70 (55%), Gaps = 1/70 (1%)

Query: 165 NEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHP 224
           +++E   ++G G    V         +  AIK+I ++   +T   ++L+E++ ++   HP
Sbjct: 15  DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKC-QTSMDELLKEIQAMSQCHHP 73

Query: 225 NIVGYHTAWI 234
           NIV Y+T+++
Sbjct: 74  NIVSYYTSFV 83


>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
          Length = 445

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 65/207 (31%), Positives = 98/207 (47%), Gaps = 22/207 (10%)

Query: 380 LHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANV--ATKIFQELVEGVFYIHNMG 437
           L+I M+ CE      ++ +  + R+Y+DE     VM  +  A K      +G        
Sbjct: 82  LYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDG-----GHT 136

Query: 438 IVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYA 497
           ++HRDLKP N+FL G  Q VK+GDFGLA   IL  +T +            + VGT  Y 
Sbjct: 137 VLHRDLKPANVFLDGK-QNVKLGDFGLA--RILNHDTSFAK----------TFVGTPYYM 183

Query: 498 SPEQLEGSEYDAKSDMYSLGVVLLEL--FQPFGTEMERAEVLTGLRTGQLPESLRKRCPV 555
           SPEQ+    Y+ KSD++SLG +L EL    P  T   + E+   +R G+      +    
Sbjct: 184 SPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDE 243

Query: 556 QAKYIQHLTRRNSSQRPSAIQLLQSEL 582
             + I  +       RPS  ++L++ L
Sbjct: 244 LNEIITRMLNLKDYHRPSVEEILENPL 270



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 25/73 (34%), Positives = 40/73 (54%)

Query: 166 EFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPN 225
           ++E L  +G G YGR  K+R K DG+    K++     T+     ++ EV +L  L+HPN
Sbjct: 7   DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66

Query: 226 IVGYHTAWIEHVH 238
           IV Y+   I+  +
Sbjct: 67  IVRYYDRIIDRTN 79


>gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
           [Homo sapiens]
          Length = 545

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 70/251 (27%), Positives = 121/251 (48%), Gaps = 29/251 (11%)

Query: 389 LSLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNI 448
           L +  +IV R +     ++E+        +   I +E++EG+ Y+H  G +HRDLK  NI
Sbjct: 147 LDIIKYIVNRGEHKNGVLEEA--------IIATILKEVLEGLDYLHRNGQIHRDLKAGNI 198

Query: 449 FLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSE-Y 507
            L G D  V+I DFG++    L    D T    ++T      VGT  + +PE +E    Y
Sbjct: 199 LL-GEDGSVQIADFGVSA--FLATGGDVTRNKVRKT-----FVGTPCWMAPEVMEQVRGY 250

Query: 508 DAKSDMYSLGVVLLEL---------FQPFGTEMERAE-VLTGLRTG-QLPESLRKRCPVQ 556
           D K+DM+S G+  +EL         + P    M   +     L TG +  E ++K     
Sbjct: 251 DFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSF 310

Query: 557 AKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQEKEIAELKKQLNLLSQ 616
            K +    +++ S+RP+A +LL+ + FQ + N    ++ K++ +  +IA+  K++  +  
Sbjct: 311 RKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIE-KLLTRTPDIAQRAKKVRRVPG 369

Query: 617 DKGVRDDGKDG 627
             G     +DG
Sbjct: 370 SSGHLHKTEDG 380



 Score = 33.5 bits (75), Expect = 0.61
 Identities = 18/68 (26%), Positives = 38/68 (55%), Gaps = 1/68 (1%)

Query: 167 FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNI 226
           +E   ++G G    V     K   +  AIK+I ++   +T   ++L+E++ ++   HPN+
Sbjct: 63  YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKC-QTSMDELLKEIQAMSQCSHPNV 121

Query: 227 VGYHTAWI 234
           V Y+T+++
Sbjct: 122 VTYYTSFV 129


>gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
          Length = 470

 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 64/194 (32%), Positives = 99/194 (51%), Gaps = 24/194 (12%)

Query: 423 FQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGK 482
           F +L+ GV Y+H   I+HRDLK +N+FL   +  +KIGDFG++   +L  + D       
Sbjct: 139 FIQLLLGVDYMHERRILHRDLKSKNVFLK--NNLLKIGDFGVS--RLLMGSCDLA----- 189

Query: 483 RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLEL--FQPFGTEMERAEVLTGL 540
                T+  GT  Y SPE L+   YD KSD++SL  +L E+              ++  +
Sbjct: 190 -----TTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKI 244

Query: 541 RTGQLPESLRKRCPVQAKYI-QHLTRRNSSQRPSAIQLLQ----SELFQN--SGNVNLTL 593
             G  P SL +R P +   I + +  +N S RPSAI++L+     E  QN       +TL
Sbjct: 245 VEGDTP-SLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTL 303

Query: 594 QMKIIEQEKEIAEL 607
           + K ++ +KE A +
Sbjct: 304 EDKNLDCQKEAAHI 317



 Score = 34.3 bits (77), Expect = 0.36
 Identities = 19/66 (28%), Positives = 34/66 (51%), Gaps = 3/66 (4%)

Query: 173 LGKGGYGRVYKVRNKL---DGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGY 229
           LG G +G VY V +K      +   +K+I +        ++   E ++L+ L HP IV +
Sbjct: 35  LGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKF 94

Query: 230 HTAWIE 235
           H +++E
Sbjct: 95  HASFVE 100


>gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]
          Length = 599

 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 64/194 (32%), Positives = 99/194 (51%), Gaps = 24/194 (12%)

Query: 423 FQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGK 482
           F +L+ GV Y+H   I+HRDLK +N+FL   +  +KIGDFG++   +L  + D       
Sbjct: 139 FIQLLLGVDYMHERRILHRDLKSKNVFLK--NNLLKIGDFGVS--RLLMGSCDLA----- 189

Query: 483 RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLEL--FQPFGTEMERAEVLTGL 540
                T+  GT  Y SPE L+   YD KSD++SL  +L E+              ++  +
Sbjct: 190 -----TTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKI 244

Query: 541 RTGQLPESLRKRCPVQAKYI-QHLTRRNSSQRPSAIQLLQ----SELFQN--SGNVNLTL 593
             G  P SL +R P +   I + +  +N S RPSAI++L+     E  QN       +TL
Sbjct: 245 VEGDTP-SLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTL 303

Query: 594 QMKIIEQEKEIAEL 607
           + K ++ +KE A +
Sbjct: 304 EDKNLDCQKEAAHI 317



 Score = 34.3 bits (77), Expect = 0.36
 Identities = 19/66 (28%), Positives = 34/66 (51%), Gaps = 3/66 (4%)

Query: 173 LGKGGYGRVYKVRNKL---DGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGY 229
           LG G +G VY V +K      +   +K+I +        ++   E ++L+ L HP IV +
Sbjct: 35  LGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKF 94

Query: 230 HTAWIE 235
           H +++E
Sbjct: 95  HASFVE 100


>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
          Length = 645

 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 64/194 (32%), Positives = 99/194 (51%), Gaps = 24/194 (12%)

Query: 423 FQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGK 482
           F +L+ GV Y+H   I+HRDLK +N+FL   +  +KIGDFG++   +L  + D       
Sbjct: 139 FIQLLLGVDYMHERRILHRDLKSKNVFLK--NNLLKIGDFGVS--RLLMGSCDLA----- 189

Query: 483 RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLEL--FQPFGTEMERAEVLTGL 540
                T+  GT  Y SPE L+   YD KSD++SL  +L E+              ++  +
Sbjct: 190 -----TTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKI 244

Query: 541 RTGQLPESLRKRCPVQAKYI-QHLTRRNSSQRPSAIQLLQ----SELFQN--SGNVNLTL 593
             G  P SL +R P +   I + +  +N S RPSAI++L+     E  QN       +TL
Sbjct: 245 VEGDTP-SLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTL 303

Query: 594 QMKIIEQEKEIAEL 607
           + K ++ +KE A +
Sbjct: 304 EDKNLDCQKEAAHI 317



 Score = 34.3 bits (77), Expect = 0.36
 Identities = 19/66 (28%), Positives = 34/66 (51%), Gaps = 3/66 (4%)

Query: 173 LGKGGYGRVYKVRNKL---DGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGY 229
           LG G +G VY V +K      +   +K+I +        ++   E ++L+ L HP IV +
Sbjct: 35  LGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKF 94

Query: 230 HTAWIE 235
           H +++E
Sbjct: 95  HASFVE 100


>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
          Length = 431

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 74/286 (25%), Positives = 133/286 (46%), Gaps = 32/286 (11%)

Query: 351 LEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDE-S 409
           LEE+    E+  +E +  L Q ++ Y +  +    L +  LW  I+     G   +D   
Sbjct: 57  LEEAEDEIEDIQQE-ITVLSQCDSPY-VTKYYGSYLKDTKLW--IIMEYLGGGSALDLLE 112

Query: 410 ACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFL--HGPDQQVKIGDFGLACT 467
             P     +AT I +E+++G+ Y+H+   +HRD+K  N+ L  HG   +VK+ DFG+A  
Sbjct: 113 PGPLDETQIAT-ILREILKGLDYLHSEKKIHRDIKAANVLLSEHG---EVKLADFGVA-- 166

Query: 468 DILQKNTDWTNRNGKRTPTHTSR---VGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF 524
                        G+ T T   R   VGT  + +PE ++ S YD+K+D++SLG+  +EL 
Sbjct: 167 -------------GQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELA 213

Query: 525 --QPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSEL 582
             +P  +E+   +VL  +     P           ++++    +  S RP+A +LL+ + 
Sbjct: 214 RGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 273

Query: 583 FQNSGNVNLTLQMKIIEQEKEIAELKKQLNLLSQDKGVRDDGKDGG 628
              +      L  ++I++ K     +   +  S+D     DG+  G
Sbjct: 274 ILRNAKKTSYL-TELIDRYKRWKAEQSHDDSSSEDSDAETDGQASG 318



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 18/69 (26%), Positives = 37/69 (53%), Gaps = 1/69 (1%)

Query: 167 FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNI 226
           F +L  +GKG +G V+K  +    +  AIK I ++ A   +   + +E+ VL+    P +
Sbjct: 24  FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYV 82

Query: 227 VGYHTAWIE 235
             Y+ ++++
Sbjct: 83  TKYYGSYLK 91


>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
          Length = 443

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 74/286 (25%), Positives = 133/286 (46%), Gaps = 32/286 (11%)

Query: 351 LEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDE-S 409
           LEE+    E+  +E +  L Q ++ Y +  +    L +  LW  I+     G   +D   
Sbjct: 69  LEEAEDEIEDIQQE-ITVLSQCDSPY-VTKYYGSYLKDTKLW--IIMEYLGGGSALDLLE 124

Query: 410 ACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFL--HGPDQQVKIGDFGLACT 467
             P     +AT I +E+++G+ Y+H+   +HRD+K  N+ L  HG   +VK+ DFG+A  
Sbjct: 125 PGPLDETQIAT-ILREILKGLDYLHSEKKIHRDIKAANVLLSEHG---EVKLADFGVA-- 178

Query: 468 DILQKNTDWTNRNGKRTPTHTSR---VGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF 524
                        G+ T T   R   VGT  + +PE ++ S YD+K+D++SLG+  +EL 
Sbjct: 179 -------------GQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELA 225

Query: 525 --QPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSEL 582
             +P  +E+   +VL  +     P           ++++    +  S RP+A +LL+ + 
Sbjct: 226 RGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 285

Query: 583 FQNSGNVNLTLQMKIIEQEKEIAELKKQLNLLSQDKGVRDDGKDGG 628
              +      L  ++I++ K     +   +  S+D     DG+  G
Sbjct: 286 ILRNAKKTSYL-TELIDRYKRWKAEQSHDDSSSEDSDAETDGQASG 330



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 18/69 (26%), Positives = 37/69 (53%), Gaps = 1/69 (1%)

Query: 167 FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNI 226
           F +L  +GKG +G V+K  +    +  AIK I ++ A   +   + +E+ VL+    P +
Sbjct: 36  FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYV 94

Query: 227 VGYHTAWIE 235
             Y+ ++++
Sbjct: 95  TKYYGSYLK 103


>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
            sapiens]
          Length = 1328

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 52/173 (30%), Positives = 84/173 (48%), Gaps = 11/173 (6%)

Query: 418  VATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWT 477
            V  K  +++++GV Y+H   +VHRD+K  N+ L  P   +K+ DFG A      +   W 
Sbjct: 1162 VFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLM-PTGIIKLIDFGCA------RRLAWA 1214

Query: 478  NRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF--QPFGTEMER-- 533
              NG  +    S  GT  + +PE +  S Y  KSD++S+G  + E+   +P    M+R  
Sbjct: 1215 GLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMA 1274

Query: 534  AEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNS 586
            A    G   G +P          A +++    R+  +RPSA+QLL+    + S
Sbjct: 1275 AMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLERS 1327



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 25/62 (40%), Positives = 32/62 (51%), Gaps = 5/62 (8%)

Query: 172  ILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLR----EVKVLAGLQHPNIV 227
            ILGKG YG VY       GQ  A+K++ +  + K    K  R    EV +L  L+H NIV
Sbjct: 1066 ILGKGAYGTVYCGLTS-QGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 1124

Query: 228  GY 229
             Y
Sbjct: 1125 AY 1126


>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
           sapiens]
          Length = 510

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 52/173 (30%), Positives = 84/173 (48%), Gaps = 11/173 (6%)

Query: 418 VATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWT 477
           V  K  +++++GV Y+H   +VHRD+K  N+ L  P   +K+ DFG A      +   W 
Sbjct: 344 VFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLM-PTGIIKLIDFGCA------RRLAWA 396

Query: 478 NRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF--QPFGTEMER-- 533
             NG  +    S  GT  + +PE +  S Y  KSD++S+G  + E+   +P    M+R  
Sbjct: 397 GLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMA 456

Query: 534 AEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNS 586
           A    G   G +P          A +++    R+  +RPSA+QLL+    + S
Sbjct: 457 AMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLERS 509



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 25/62 (40%), Positives = 32/62 (51%), Gaps = 5/62 (8%)

Query: 172 ILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLR----EVKVLAGLQHPNIV 227
           ILGKG YG VY       GQ  A+K++ +  + K    K  R    EV +L  L+H NIV
Sbjct: 248 ILGKGAYGTVYCGLTS-QGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 306

Query: 228 GY 229
            Y
Sbjct: 307 AY 308


>gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinase 1
           [Homo sapiens]
          Length = 671

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 64/273 (23%), Positives = 122/273 (44%), Gaps = 12/273 (4%)

Query: 310 NLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEESSEENVNFL 369
           N++  +S +   + EL   G   +S      Q L + +  +   +     E+  E    +
Sbjct: 8   NVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMM 67

Query: 370 GQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEG 429
            +   ++  ++ +   + E   +  ++E  ++G       A      +V  +I  E++EG
Sbjct: 68  NRL--RHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEG 125

Query: 430 VFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQK-NTDWTNRNGKRTPTHT 488
           + Y+H  G++H+DLKP NI +   D  +KI D GLA   +  K N +  N   +   T  
Sbjct: 126 MCYLHGKGVIHKDLKPENILVDN-DFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAK 184

Query: 489 SRVGTCLYASPEQLE--GSEYDAKSDMYSLGVVLLELF---QPFGTEMERAEVLTGLRTG 543
              GT  Y +PE L    ++   KSD+YS  VVL  +F   +P+   +   +++  +++G
Sbjct: 185 KNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSG 244

Query: 544 QLP--ESLRKRCPVQAKYIQHLT-RRNSSQRPS 573
             P  + + + CP +   +  L    N   RP+
Sbjct: 245 NRPDVDDITEYCPREIISLMKLCWEANPEARPT 277


>gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens]
          Length = 2382

 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 54/176 (30%), Positives = 83/176 (47%), Gaps = 21/176 (11%)

Query: 424 QELVEGVFYIHNMG--IVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 481
           +++++G+ ++H     I+HRDLK  NIF+ GP   VKIGD GLA                
Sbjct: 329 RQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL-------------- 374

Query: 482 KRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF---QPFGTEMERAEVLT 538
           KR     S +GT  + +PE  E  +YD   D+Y+ G+ +LE+     P+      A++  
Sbjct: 375 KRASFAKSVIGTPEFMAPEMYE-EKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYR 433

Query: 539 GLRTGQLPESLRK-RCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTL 593
            + +G  P S  K   P   + I+   R+N  +R S   LL    FQ    V + L
Sbjct: 434 RVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVEL 489



 Score = 37.7 bits (86), Expect = 0.032
 Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 5/104 (4%)

Query: 130 SAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLD 189
           SAKE  +++  +    I+++ ++ V + +   R+L    E+   G+G +  VYK  +   
Sbjct: 189 SAKEP-QEERSQQQDDIEELETKAVGM-SNDGRFLKFDIEI---GRGSFKTVYKGLDTET 243

Query: 190 GQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAW 233
               A  ++  +  TK+   +   E ++L GLQHPNIV ++ +W
Sbjct: 244 TVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSW 287


>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
           sapiens]
          Length = 648

 Score = 72.8 bits (177), Expect = 9e-13
 Identities = 55/176 (31%), Positives = 86/176 (48%), Gaps = 22/176 (12%)

Query: 422 IFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 481
           I ++  +G+ Y+H   I+HRD+K  NIFLH     VKIGDFGLA        + W+    
Sbjct: 448 IARQTAQGMDYLHAKNIIHRDMKSNNIFLH-EGLTVKIGDFGLATV-----KSRWSGSQQ 501

Query: 482 KRTPTHTSRVGTCLYASPEQL---EGSEYDAKSDMYSLGVVLLELFQ---PFGTEMERAE 535
              PT     G+ L+ +PE +   + + +  +SD+YS G+VL EL     P+     R +
Sbjct: 502 VEQPT-----GSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQ 556

Query: 536 VLTGLRTGQLP---ESLRKRCP-VQAKYIQHLTRRNSSQRPSAIQLLQS-ELFQNS 586
           ++  +  G        L K CP    + +    ++   +RP   Q+L S EL Q+S
Sbjct: 557 IIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHS 612


>gi|33188459 B-Raf [Homo sapiens]
          Length = 766

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 53/169 (31%), Positives = 82/169 (48%), Gaps = 21/169 (12%)

Query: 422 IFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 481
           I ++  +G+ Y+H   I+HRDLK  NIFLH  D  VKIGDFGLA        + W+  + 
Sbjct: 556 IARQTAQGMDYLHAKSIIHRDLKSNNIFLH-EDLTVKIGDFGLATV-----KSRWSGSH- 608

Query: 482 KRTPTHTSRVGTCLYASPEQL---EGSEYDAKSDMYSLGVVLLELFQ---PFGTEMERAE 535
                     G+ L+ +PE +   + + Y  +SD+Y+ G+VL EL     P+     R +
Sbjct: 609 ----QFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ 664

Query: 536 VLTGLRTGQLPESL---RKRCPVQAKYIQ-HLTRRNSSQRPSAIQLLQS 580
           ++  +  G L   L   R  CP   K +     ++   +RP   Q+L S
Sbjct: 665 IIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILAS 713


>gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]
          Length = 1243

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 57/204 (27%), Positives = 96/204 (47%), Gaps = 24/204 (11%)

Query: 424 QELVEGVFYIHNM--GIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 481
           ++++ G+ ++H+    I+HRDLK  N+F+ GP   VKIGD GLA                
Sbjct: 282 RQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATL-------------- 327

Query: 482 KRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF---QPFGTEMERAEVLT 538
           KR     S +GT  + +PE  E  +YD   D+Y+ G+ +LE+     P+      A++  
Sbjct: 328 KRASFAKSVIGTPEFMAPEMYE-EKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYR 386

Query: 539 GLRTGQLPESLRK-RCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKI 597
            + +G+ P S  K + P   + I+   R + ++R +   LL    F+    V++ L    
Sbjct: 387 KVTSGRKPNSFHKVKIPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREERGVHVELAE-- 444

Query: 598 IEQEKEIAELKKQLNLLSQDKGVR 621
            E + E   LK  L +    +G R
Sbjct: 445 -EDDGEKPGLKLWLRMEDARRGGR 467



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 17/61 (27%), Positives = 33/61 (54%)

Query: 173 LGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTA 232
           +G+G +  VY+  +       A  ++  +  ++    +   EV++L GLQHPNIV ++ +
Sbjct: 180 IGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDS 239

Query: 233 W 233
           W
Sbjct: 240 W 240


>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
           sapiens]
          Length = 416

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 67/245 (27%), Positives = 117/245 (47%), Gaps = 27/245 (11%)

Query: 341 QQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNK 400
           QQ+   +   LEE+    E+  +E +  L Q ++ Y +  +    L    LW  I+    
Sbjct: 47  QQVVAIKIIDLEEAEDEIEDIQQE-ITVLSQCDSSY-VTKYYGSYLKGSKLW--IIMEYL 102

Query: 401 RGREYVDE-SACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKI 459
            G   +D   A P+    +AT + +E+++G+ Y+H+   +HRD+K  N+ L      VK+
Sbjct: 103 GGGSALDLLRAGPFDEFQIATML-KEILKGLDYLHSEKKIHRDIKAANVLL-SEQGDVKL 160

Query: 460 GDFGLACTDILQKNTDWTNRNGKRTPTHTSR---VGTCLYASPEQLEGSEYDAKSDMYSL 516
            DFG+A               G+ T T   R   VGT  + +PE ++ S YD+K+D++SL
Sbjct: 161 ADFGVA---------------GQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSL 205

Query: 517 GVVLLELF--QPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSA 574
           G+  +EL   +P  ++M    VL  +     P  +        ++I     ++ S RP+A
Sbjct: 206 GITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTA 265

Query: 575 IQLLQ 579
            +LL+
Sbjct: 266 KELLK 270


>gi|50845418 WNK lysine deficient protein kinase 3 isoform 1 [Homo
           sapiens]
          Length = 1800

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 53/176 (30%), Positives = 82/176 (46%), Gaps = 21/176 (11%)

Query: 424 QELVEGVFYIHNMG--IVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 481
           +++++G+ ++H     I+HRDLK  NIF+ GP   VKIGD GLA                
Sbjct: 255 RQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL-------------- 300

Query: 482 KRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF---QPFGTEMERAEVLT 538
            RT    S +GT  + +PE  E   YD   D+Y+ G+ +LE+     P+      A++  
Sbjct: 301 MRTSFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYR 359

Query: 539 GLRTGQLPESLRKRCPVQAK-YIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTL 593
            + +G  P S  K    + K  I+   R+N S+R S   LL    F     + + L
Sbjct: 360 KVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVEL 415



 Score = 37.7 bits (86), Expect = 0.032
 Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 1/88 (1%)

Query: 147 QKIRSREVALEAQTSRYLNEFEELAI-LGKGGYGRVYKVRNKLDGQYYAIKKILIKGATK 205
           +K    E  ++A  +     F +  I LG+G +  VYK  +       A  ++  +  TK
Sbjct: 126 EKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTK 185

Query: 206 TVCMKVLREVKVLAGLQHPNIVGYHTAW 233
               +   E ++L GLQHPNIV ++ +W
Sbjct: 186 AEQQRFKEEAEMLKGLQHPNIVRFYDSW 213


>gi|50845416 WNK lysine deficient protein kinase 3 isoform 2 [Homo
           sapiens]
          Length = 1743

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 53/176 (30%), Positives = 82/176 (46%), Gaps = 21/176 (11%)

Query: 424 QELVEGVFYIHNMG--IVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNG 481
           +++++G+ ++H     I+HRDLK  NIF+ GP   VKIGD GLA                
Sbjct: 255 RQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL-------------- 300

Query: 482 KRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF---QPFGTEMERAEVLT 538
            RT    S +GT  + +PE  E   YD   D+Y+ G+ +LE+     P+      A++  
Sbjct: 301 MRTSFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYR 359

Query: 539 GLRTGQLPESLRKRCPVQAK-YIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTL 593
            + +G  P S  K    + K  I+   R+N S+R S   LL    F     + + L
Sbjct: 360 KVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVEL 415



 Score = 37.7 bits (86), Expect = 0.032
 Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 1/88 (1%)

Query: 147 QKIRSREVALEAQTSRYLNEFEELAI-LGKGGYGRVYKVRNKLDGQYYAIKKILIKGATK 205
           +K    E  ++A  +     F +  I LG+G +  VYK  +       A  ++  +  TK
Sbjct: 126 EKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTK 185

Query: 206 TVCMKVLREVKVLAGLQHPNIVGYHTAW 233
               +   E ++L GLQHPNIV ++ +W
Sbjct: 186 AEQQRFKEEAEMLKGLQHPNIVRFYDSW 213


>gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Homo
           sapiens]
          Length = 339

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 55/192 (28%), Positives = 95/192 (49%), Gaps = 23/192 (11%)

Query: 394 WIVERNKRGREYVDE-SACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHG 452
           WI+     G   +D   A P+    +AT + +E+++G+ Y+H+   +HRD+K  N+ L  
Sbjct: 19  WIIMEYLGGGSALDLLRAGPFDEFQIATML-KEILKGLDYLHSEKKIHRDIKAANVLL-S 76

Query: 453 PDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSR---VGTCLYASPEQLEGSEYDA 509
               VK+ DFG+A               G+ T T   R   VGT  + +PE ++ S YD+
Sbjct: 77  EQGDVKLADFGVA---------------GQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDS 121

Query: 510 KSDMYSLGVVLLELF--QPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRN 567
           K+D++SLG+  +EL   +P  ++M    VL  +     P  +        ++I     ++
Sbjct: 122 KADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKD 181

Query: 568 SSQRPSAIQLLQ 579
            S RP+A +LL+
Sbjct: 182 PSFRPTAKELLK 193


>gi|156105707 SNF related kinase [Homo sapiens]
          Length = 765

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 52/162 (32%), Positives = 81/162 (50%), Gaps = 21/162 (12%)

Query: 417 NVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDW 476
           ++A K F ++V  + Y H + +VHRDLKP N+        VK+ DFG +           
Sbjct: 114 DLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSN---------- 163

Query: 477 TNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKS-DMYSLGVVLLELF--QPFGTEMER 533
             + GK+    T+  G+  Y++PE L G EYDA + D++SLGV+L  L   QP   E   
Sbjct: 164 KFQPGKKL---TTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEAND 220

Query: 534 AEVLTGLRTGQ--LPESLRKRCPVQAKYIQHLTRRNSSQRPS 573
           +E LT +   +  +P  + K C      I  + +R+  +R S
Sbjct: 221 SETLTMIMDCKYTVPSHVSKEC---KDLITRMLQRDPKRRAS 259


>gi|156105705 SNF related kinase [Homo sapiens]
          Length = 765

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 52/162 (32%), Positives = 81/162 (50%), Gaps = 21/162 (12%)

Query: 417 NVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDW 476
           ++A K F ++V  + Y H + +VHRDLKP N+        VK+ DFG +           
Sbjct: 114 DLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSN---------- 163

Query: 477 TNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKS-DMYSLGVVLLELF--QPFGTEMER 533
             + GK+    T+  G+  Y++PE L G EYDA + D++SLGV+L  L   QP   E   
Sbjct: 164 KFQPGKKL---TTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEAND 220

Query: 534 AEVLTGLRTGQ--LPESLRKRCPVQAKYIQHLTRRNSSQRPS 573
           +E LT +   +  +P  + K C      I  + +R+  +R S
Sbjct: 221 SETLTMIMDCKYTVPSHVSKEC---KDLITRMLQRDPKRRAS 259


>gi|21359873 polo-like kinase 1 [Homo sapiens]
          Length = 603

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 59/193 (30%), Positives = 93/193 (48%), Gaps = 29/193 (15%)

Query: 395 IVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPD 454
           ++E +KR +   +  A  Y+         +++V G  Y+H   ++HRDLK  N+FL+  D
Sbjct: 138 LLELHKRRKALTEPEARYYL---------RQIVLGCQYLHRNRVIHRDLKLGNLFLN-ED 187

Query: 455 QQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMY 514
            +VKIGDFGLA              +G+R  T     GT  Y +PE L    +  + D++
Sbjct: 188 LEVKIGDFGLATK---------VEYDGERKKT---LCGTPNYIAPEVLSKKGHSFEVDVW 235

Query: 515 SLGVVLLELF---QPFGTEMERAEVLTGLRTGQLPESLRKRC-PVQAKYIQHLTRRNSSQ 570
           S+G ++  L     PF T   +    T LR  +   S+ K   PV A  IQ + + + + 
Sbjct: 236 SIGCIMYTLLVGKPPFETSCLKE---TYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTA 292

Query: 571 RPSAIQLLQSELF 583
           RP+  +LL  E F
Sbjct: 293 RPTINELLNDEFF 305



 Score = 29.6 bits (65), Expect = 8.8
 Identities = 16/62 (25%), Positives = 33/62 (53%), Gaps = 7/62 (11%)

Query: 173 LGKGGYGRVYKVRNKLDGQYYA----IKKILIKGATKTVCMKVLREVKVLAGLQHPNIVG 228
           LGKGG+ + +++ +    + +A     K +L+K   +    K+  E+ +   L H ++VG
Sbjct: 59  LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQRE---KMSMEISIHRSLAHQHVVG 115

Query: 229 YH 230
           +H
Sbjct: 116 FH 117


>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
          Length = 426

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 67/285 (23%), Positives = 125/285 (43%), Gaps = 26/285 (9%)

Query: 351 LEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESA 410
           LEE+    E+  +E +  L Q ++ Y +  +    L    LW  I+     G   +D   
Sbjct: 53  LEEAEDEIEDIQQE-ITVLSQCDSPY-ITRYFGSYLKSTKLW--IIMEYLGGGSALDLLK 108

Query: 411 CPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDIL 470
              +       I +E+++G+ Y+H+   +HRD+K  N+ L      VK+ DFG+A     
Sbjct: 109 PGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLL-SEQGDVKLADFGVA----- 162

Query: 471 QKNTDWTNRNGKRTPTHTSR---VGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELF--Q 525
                     G+ T T   R   VGT  + +PE ++ S YD K+D++SLG+  +EL   +
Sbjct: 163 ----------GQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGE 212

Query: 526 PFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQN 585
           P  +++    VL  +     P    +      ++++    ++   RP+A +LL+ + F  
Sbjct: 213 PPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHK-FIT 271

Query: 586 SGNVNLTLQMKIIEQEKEIAELKKQLNLLSQDKGVRDDGKDGGVG 630
                 +   ++I++ K            S+D  +  + +DG  G
Sbjct: 272 RYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSDIDGEAEDGEQG 316



 Score = 31.2 bits (69), Expect = 3.0
 Identities = 20/69 (28%), Positives = 36/69 (52%), Gaps = 1/69 (1%)

Query: 167 FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNI 226
           F +L  +GKG +G VYK  +    +  AIK I ++ A   +   + +E+ VL+    P I
Sbjct: 20  FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYI 78

Query: 227 VGYHTAWIE 235
             Y  ++++
Sbjct: 79  TRYFGSYLK 87


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,337,978
Number of Sequences: 37866
Number of extensions: 1126388
Number of successful extensions: 6185
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 541
Number of HSP's successfully gapped in prelim test: 268
Number of HSP's that attempted gapping in prelim test: 4058
Number of HSP's gapped (non-prelim): 1630
length of query: 630
length of database: 18,247,518
effective HSP length: 108
effective length of query: 522
effective length of database: 14,157,990
effective search space: 7390470780
effective search space used: 7390470780
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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