Guide to the Human Genome
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Search of human proteins with 110611908

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|110611908 mitogen-activated protein kinase kinase kinase
kinase 1 isoform 1 [Homo sapiens]
         (821 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|110611908 mitogen-activated protein kinase kinase kinase kina...  1676   0.0  
gi|6005810 mitogen-activated protein kinase kinase kinase kinase...  1632   0.0  
gi|38570135 mitogen-activated protein kinase kinase kinase kinas...   739   0.0  
gi|14589909 mitogen-activated protein kinase kinase kinase kinas...   739   0.0  
gi|15451902 mitogen-activated protein kinase kinase kinase kinas...   720   0.0  
gi|22035600 mitogen-activated protein kinase kinase kinase kinas...   646   0.0  
gi|5454096 serine/threonine kinase 4 [Homo sapiens]                   250   4e-66
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa...   244   2e-64
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa...   244   2e-64
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa...   244   2e-64
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa...   244   2e-64
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa...   244   2e-64
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa...   244   2e-64
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa...   244   2e-64
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap...   244   2e-64
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo...   244   2e-64
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]      243   5e-64
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]       243   5e-64
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]     242   9e-64
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]     242   9e-64
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]     242   9e-64
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]      242   9e-64
gi|21361358 serine/threonine kinase 25 [Homo sapiens]                 242   9e-64
gi|103471999 serine/threonine kinase 3 [Homo sapiens]                 241   3e-63
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...   239   1e-62
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...   239   1e-62
gi|22035604 mitogen-activated protein kinase kinase kinase kinas...   239   1e-62
gi|126362971 serine/threonine kinase 10 [Homo sapiens]                236   6e-62
gi|145275208 myosin IIIA [Homo sapiens]                               218   2e-56
gi|41281453 serine/threonine kinase 2 [Homo sapiens]                  216   9e-56

>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
           1 isoform 1 [Homo sapiens]
          Length = 821

 Score = 1676 bits (4341), Expect = 0.0
 Identities = 821/821 (100%), Positives = 821/821 (100%)

Query: 1   MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ 60
           MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
Sbjct: 1   MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ 60

Query: 61  KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE 120
           KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
Sbjct: 61  KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE 120

Query: 121 VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA 180
           VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
Sbjct: 121 VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA 180

Query: 181 PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
           PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
Sbjct: 181 PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240

Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
           GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
Sbjct: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300

Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
           GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
Sbjct: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360

Query: 361 PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL 420
           PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
Sbjct: 361 PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL 420

Query: 421 SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK 480
           SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
Sbjct: 421 SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK 480

Query: 481 RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS 540
           RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
Sbjct: 481 RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS 540

Query: 541 RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK 600
           RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
Sbjct: 541 RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK 600

Query: 601 IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF 660
           IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
Sbjct: 601 IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF 660

Query: 661 ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM 720
           ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
Sbjct: 661 ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM 720

Query: 721 VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ 780
           VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
Sbjct: 721 VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ 780

Query: 781 LLQELRDPTLTFRLLGSPRPVVVETRPVDDPTAPSNLYIQE 821
           LLQELRDPTLTFRLLGSPRPVVVETRPVDDPTAPSNLYIQE
Sbjct: 781 LLQELRDPTLTFRLLGSPRPVVVETRPVDDPTAPSNLYIQE 821


>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
           isoform 2 [Homo sapiens]
          Length = 833

 Score = 1632 bits (4226), Expect = 0.0
 Identities = 799/799 (100%), Positives = 799/799 (100%)

Query: 1   MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ 60
           MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
Sbjct: 1   MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ 60

Query: 61  KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE 120
           KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
Sbjct: 61  KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE 120

Query: 121 VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA 180
           VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
Sbjct: 121 VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA 180

Query: 181 PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
           PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
Sbjct: 181 PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240

Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
           GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
Sbjct: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300

Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
           GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
Sbjct: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360

Query: 361 PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL 420
           PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
Sbjct: 361 PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL 420

Query: 421 SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK 480
           SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
Sbjct: 421 SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK 480

Query: 481 RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS 540
           RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
Sbjct: 481 RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS 540

Query: 541 RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK 600
           RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
Sbjct: 541 RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK 600

Query: 601 IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF 660
           IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
Sbjct: 601 IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF 660

Query: 661 ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM 720
           ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
Sbjct: 661 ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM 720

Query: 721 VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ 780
           VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
Sbjct: 721 VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ 780

Query: 781 LLQELRDPTLTFRLLGSPR 799
           LLQELRDPTLTFRLLGSPR
Sbjct: 781 LLQELRDPTLTFRLLGSPR 799


>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
           [Homo sapiens]
          Length = 846

 Score =  739 bits (1909), Expect = 0.0
 Identities = 397/846 (46%), Positives = 541/846 (63%), Gaps = 50/846 (5%)

Query: 7   DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 66
           DI  R+P+  Y+L+QR+G GTYG+V+KAR+  +G+L A+K++K+EP DD S +Q+EI ++
Sbjct: 10  DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMV 69

Query: 67  KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 126
           K C+H NIVAY GSYL  +KLWICME+CG GSLQDIY VTG LSELQI+YVCRE LQGLA
Sbjct: 70  KECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLA 129

Query: 127 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV 186
           YLH++ K+HRDIKGANIL+ D G+V+LADFG++A+I AT+A+R SFIGTPYWMAPEVAAV
Sbjct: 130 YLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAV 189

Query: 187 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAA 246
              GGYN+LCDIW++GITAIEL ELQPP+FD+HP+R LFLM+KS +QPP+LK+K KWS+ 
Sbjct: 190 EKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 249

Query: 247 FHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDE 306
           FHNF+K+ LTK+PKKRP+A ++L+H  V+QPGL+R L ++LLDK+ NP       + +D+
Sbjct: 250 FHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDD 309

Query: 307 EPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRS 366
           + E    I   IRST+R++      A+     + F KL   +  PP             S
Sbjct: 310 DFEPHAIIRHTIRSTNRNAR-----AERTASEINFDKL---QFEPPLRKETEARDEMGLS 361

Query: 367 SSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRS-PSDEGPGS--------MGDD 417
           S P   L  +   D  +    T     PPPLPPKP+  S P D  P            D 
Sbjct: 362 SDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDS 421

Query: 418 GQLSPGVLVRCASGPPPNSPRPGPPPSTS--------SPHLTAHSEPSLWNP------PS 463
              +P +L R       +SP  GP   TS        S  ++ ++E S   P        
Sbjct: 422 ESRAPQILRR------QSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDK 475

Query: 464 RELDKPPL--LPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEG 521
           R+  KP +  LPP  + +     A   K+F+GCPL+I+   +W HP TKDQ+++ G E+G
Sbjct: 476 RDFPKPAINGLPPTPKVLMG---ACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDG 532

Query: 522 IFILNRND-QEATLEMLFPSRTTWVYSINNVLMSLS-GKTPHLYSHSILGLLE--RKETR 577
           I+ LN N+  EAT+E LFP + TW+Y INN LMSLS GKT  LYSH+++ L E  +K   
Sbjct: 533 IYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGL 592

Query: 578 AGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWY 637
           A +   H  P R+L RK  ++TKI DTKGC  CC+     +G  +LCGAL++ +VLLQWY
Sbjct: 593 AAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWY 652

Query: 638 QPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVL-FHTVRFGAL 696
           +PM KF+L++   FPLP+PL+VF +L  P  E P VC+ +S G     V+ F T+   + 
Sbjct: 653 EPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSA 712

Query: 697 SCWLGEM--STEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLR-TPEIPMTEAV 753
           S W  E+   ++    + VTQ+E D V+V +D  VK+V  +G      +   E+     +
Sbjct: 713 SSWFTEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRI 772

Query: 754 EAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRPVVVETRPVDDPTA 813
           E+V  +   + AFWKHG+Q  +  SD++ QE+ D T  FRLLGS R VV+E+RP ++PTA
Sbjct: 773 ESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTA 832

Query: 814 PSNLYI 819
            SNLYI
Sbjct: 833 HSNLYI 838


>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
           [Homo sapiens]
          Length = 846

 Score =  739 bits (1909), Expect = 0.0
 Identities = 397/846 (46%), Positives = 541/846 (63%), Gaps = 50/846 (5%)

Query: 7   DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 66
           DI  R+P+  Y+L+QR+G GTYG+V+KAR+  +G+L A+K++K+EP DD S +Q+EI ++
Sbjct: 10  DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMV 69

Query: 67  KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 126
           K C+H NIVAY GSYL  +KLWICME+CG GSLQDIY VTG LSELQI+YVCRE LQGLA
Sbjct: 70  KECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLA 129

Query: 127 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV 186
           YLH++ K+HRDIKGANIL+ D G+V+LADFG++A+I AT+A+R SFIGTPYWMAPEVAAV
Sbjct: 130 YLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAV 189

Query: 187 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAA 246
              GGYN+LCDIW++GITAIEL ELQPP+FD+HP+R LFLM+KS +QPP+LK+K KWS+ 
Sbjct: 190 EKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 249

Query: 247 FHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDE 306
           FHNF+K+ LTK+PKKRP+A ++L+H  V+QPGL+R L ++LLDK+ NP       + +D+
Sbjct: 250 FHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDD 309

Query: 307 EPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRS 366
           + E    I   IRST+R++      A+     + F KL   +  PP             S
Sbjct: 310 DFEPHAIIRHTIRSTNRNAR-----AERTASEINFDKL---QFEPPLRKETEARDEMGLS 361

Query: 367 SSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRS-PSDEGPGS--------MGDD 417
           S P   L  +   D  +    T     PPPLPPKP+  S P D  P            D 
Sbjct: 362 SDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDS 421

Query: 418 GQLSPGVLVRCASGPPPNSPRPGPPPSTS--------SPHLTAHSEPSLWNP------PS 463
              +P +L R       +SP  GP   TS        S  ++ ++E S   P        
Sbjct: 422 ESRAPQILRR------QSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDK 475

Query: 464 RELDKPPL--LPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEG 521
           R+  KP +  LPP  + +     A   K+F+GCPL+I+   +W HP TKDQ+++ G E+G
Sbjct: 476 RDFPKPAINGLPPTPKVLMG---ACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDG 532

Query: 522 IFILNRND-QEATLEMLFPSRTTWVYSINNVLMSLS-GKTPHLYSHSILGLLE--RKETR 577
           I+ LN N+  EAT+E LFP + TW+Y INN LMSLS GKT  LYSH+++ L E  +K   
Sbjct: 533 IYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGL 592

Query: 578 AGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWY 637
           A +   H  P R+L RK  ++TKI DTKGC  CC+     +G  +LCGAL++ +VLLQWY
Sbjct: 593 AAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWY 652

Query: 638 QPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVL-FHTVRFGAL 696
           +PM KF+L++   FPLP+PL+VF +L  P  E P VC+ +S G     V+ F T+   + 
Sbjct: 653 EPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSA 712

Query: 697 SCWLGEM--STEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLR-TPEIPMTEAV 753
           S W  E+   ++    + VTQ+E D V+V +D  VK+V  +G      +   E+     +
Sbjct: 713 SSWFTEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRI 772

Query: 754 EAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRPVVVETRPVDDPTA 813
           E+V  +   + AFWKHG+Q  +  SD++ QE+ D T  FRLLGS R VV+E+RP ++PTA
Sbjct: 773 ESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTA 832

Query: 814 PSNLYI 819
            SNLYI
Sbjct: 833 HSNLYI 838


>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
           [Homo sapiens]
          Length = 894

 Score =  720 bits (1858), Expect = 0.0
 Identities = 399/890 (44%), Positives = 542/890 (60%), Gaps = 86/890 (9%)

Query: 7   DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 66
           D+  R+P++ ++L+QR+G GTYG+V+KAR+  +G+L A+K++K+EP +D + +Q+EI+++
Sbjct: 6   DLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMM 65

Query: 67  KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 126
           K C+H NIVAY GSYL   KLWICMEFCG GSLQDIY VTG LSELQI+YV RE LQGL 
Sbjct: 66  KDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLY 125

Query: 127 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV 186
           YLHS+ K+HRDIKGANIL+ D G V+LADFG+SAQI AT+A+R SFIGTPYWMAPEVAAV
Sbjct: 126 YLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAV 185

Query: 187 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAA 246
             KGGYN+LCD+W++GITAIELAELQPP+FD+HP+R LFLMTKS +QPP+LK+K KWS +
Sbjct: 186 ERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNS 245

Query: 247 FHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDE 306
           FH+F+K+ LTK+PKKRP+A K+L H  V+Q  L R L ++LLDK+ NP    +  D +D+
Sbjct: 246 FHHFVKMALTKNPKKRPTAEKLLQHPFVTQ-HLTRSLAIELLDKVNNPDHS-TYHDFDDD 303

Query: 307 EPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRP----PANTARLQPPR 362
           +PE   A+P RI ST R+       ++     ++F      ET P    P +   L    
Sbjct: 304 DPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSE 363

Query: 363 DL----RSS-------------------------------SPRKQLSESSDDDYDDVDI- 386
           ++    RS+                                 R  ++   DD+ DD +  
Sbjct: 364 EIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESK 423

Query: 387 -PTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRC-ASGPP--PNSPRPGPP 442
             T     PPPLPPKPK    S   P  M      + G + RC  SG P  P+   P PP
Sbjct: 424 HSTLKAKIPPPLPPKPK----SIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPP 479

Query: 443 PSTSSPH-------------------------LTAHSEPSLWNPPSRELDKPPL--LPPK 475
           P    PH                            H   +L     +++ KP    LPP 
Sbjct: 480 PPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPP- 538

Query: 476 KEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRND-QEATL 534
             K+    C    K+FNGCPL+IH  ++W +P T+DQ+L+ GAEEGI+ LN N+  E ++
Sbjct: 539 TPKVHMGAC--FSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSM 596

Query: 535 EMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPI---AHISPHRLL 591
           E LFP R TW+Y +NN L+S+SGK   LYSH++ GL +        P+   AH  P R+L
Sbjct: 597 EQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRIL 656

Query: 592 ARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLF 651
            RK  VS KI +TK C+ CCV     +G  +LCGAL+TS+VLL+W +PM KF+L++ + F
Sbjct: 657 PRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDF 716

Query: 652 PLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVL-FHTVRFGALSCWLGEMSTEHRGP 710
           P+P PL +F +L  P  E P VC+GVS GR    V+ F TV   + S W  E  T     
Sbjct: 717 PIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNV 776

Query: 711 VQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLR-TPEIPMTEAVEAVAMVGGQLQAFWKH 769
             VTQ+E D ++V +D  +K+V  +G      + + E+     +E++  +   + AFWKH
Sbjct: 777 THVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKH 836

Query: 770 GVQVWALGSDQLLQELRDPTLTFRLLGSPRPVVVETRPVDDPTAPSNLYI 819
           G+Q  +  S+++ QE+ D T  FRLLGS R VV+E+RP D+PTA SNLYI
Sbjct: 837 GMQGRSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYI 886


>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
           [Homo sapiens]
          Length = 820

 Score =  646 bits (1666), Expect = 0.0
 Identities = 362/845 (42%), Positives = 502/845 (59%), Gaps = 70/845 (8%)

Query: 7   DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 66
           D+  +DPRD ++LLQR+G GTYG+V+KARD V+ +L A+K+VK++P DD+S+LQ+EI IL
Sbjct: 6   DVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITIL 65

Query: 67  KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 126
           + CRH N+VAY GSYL   +LWICMEFCG GSLQ+IY  TG L E QI+YVCRE L+GL 
Sbjct: 66  RECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLH 125

Query: 127 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV 186
           +LHSQ KIHRDIKGAN+L+   G+V+LADFG+S ++ A++A+R SFIGTPYWMAPEVAAV
Sbjct: 126 HLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAV 185

Query: 187 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAA 246
             KGGYNELCD+W+LGITAIEL ELQPPLF +HP+R L LM+KS +QPP+L++K +W+  
Sbjct: 186 ERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQN 245

Query: 247 FHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKG-PSIGDIED 305
           FH+F+K+ LTK+PKKRP+A K+L H   +Q  L R L+  LLDK  +P  G PS  D E 
Sbjct: 246 FHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDPHLGTPSPEDCEL 304

Query: 306 EEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPP---- 361
           E  ++    P  I S  +        ++     ++F   R  ET P      L  P    
Sbjct: 305 ETYDM---FPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDP------LNEPWEEE 355

Query: 362 --------------RDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPP------PLPPKP 401
                         + ++ +   + L+  S  ++ ++D P     T        PLP  P
Sbjct: 356 WTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQELDSPDDTMGTIKRAPFLGPLPTDP 415

Query: 402 KFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNP 461
               P    PG++                 PPP+ P   P   T+   +    +P     
Sbjct: 416 PAEEPLSSPPGTL----------------PPPPSGPNSSPLLPTAWATMKQREDP----- 454

Query: 462 PSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEG 521
              E      LPP   K+    C    K+FNGCPLRIH+   W HP T+DQ L++GAEEG
Sbjct: 455 ---ERSSCHGLPP-TPKVHMGAC--FSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEG 508

Query: 522 IFILNRND-QEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGN 580
           I+ LN ++  E TLE L   R +W+Y +NNVL+SLSGK+ H+++H + GL E++  +   
Sbjct: 509 IYTLNLHELHEDTLEKLISHRCSWLYCVNNVLLSLSGKSTHIWAHDLPGLFEQRRLQQQV 568

Query: 581 PIA---HISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWY 637
           P++   +    R++ R+  +STKI DTKGC  C V     +G  FL  AL TS++LLQWY
Sbjct: 569 PLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQCRVVRNPYTGATFLLAALPTSLLLLQWY 628

Query: 638 QPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGV-SPGRPGKSVLFHT--VRFG 694
           +P+ KFLL++    PLP+P  +   L   G ELP VC+G   P  PG  VLFH   +  G
Sbjct: 629 EPLQKFLLLKNFSSPLPSPAGMLEPLVLDGKELPQVCVGAEGPEGPGCRVLFHVLPLEAG 688

Query: 695 ALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVE 754
                L           QV QV+ D ++V  +  V++V  +G P   L  PE+     +E
Sbjct: 689 LTPDILIPPEGIPGSAQQVIQVDRDTILVSFERCVRIVNMQGEPTATL-APELTFDFPIE 747

Query: 755 AVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRPVVVETRPVDDPTAP 814
            V  +   + AFW HG+Q  +L ++++ QE+ D T  FR+LG+ R +++E+ P D+P A 
Sbjct: 748 TVVCLQDSVLAFWSHGMQGRSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPEAH 807

Query: 815 SNLYI 819
           SNLYI
Sbjct: 808 SNLYI 812


>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
          Length = 487

 Score =  250 bits (638), Expect = 4e-66
 Identities = 136/309 (44%), Positives = 201/309 (65%), Gaps = 12/309 (3%)

Query: 4   VDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEI 63
           +D D   + P + +D+L++LG G+YG V+KA  K +G +VA+K V +E   D+  + KEI
Sbjct: 17  LDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE--SDLQEIIKEI 74

Query: 64  LILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG-SLSELQISYVCREVL 122
            I++ C   ++V Y+GSY     LWI ME+CGAGS+ DI ++   +L+E +I+ + +  L
Sbjct: 75  SIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTL 134

Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
           +GL YLH  +KIHRDIK  NIL+N  G  +LADFG++ Q+  T+A+R + IGTP+WMAPE
Sbjct: 135 KGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 194

Query: 183 VAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGK 242
           V     + GYN + DIWSLGITAIE+AE +PP  D+HP+R +F++  +   PP  ++   
Sbjct: 195 VIQ---EIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPEL 249

Query: 243 WSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV-SQPGLN--RGLILDLLD-KLKNPGKGP 298
           WS  F +F+K  L KSP++R +AT++L H  V S  G++  R LI + +D KLK      
Sbjct: 250 WSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQ 309

Query: 299 SIGDIEDEE 307
              D +DEE
Sbjct: 310 REVDQDDEE 318


>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
           sapiens]
          Length = 1268

 Score =  244 bits (624), Expect = 2e-64
 Identities = 141/375 (37%), Positives = 210/375 (56%), Gaps = 13/375 (3%)

Query: 11  RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
           RDP   ++L++ +G GTYG+V+K R   +G L A+K++ +  D++    Q+  ++ K   
Sbjct: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH 78

Query: 71  HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
           H NI  Y+G+++         +LW+ MEFCGAGS+ D+ + T   +L E  I+Y+CRE+L
Sbjct: 79  HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138

Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
           +GL++LH  K IHRDIKG N+L+ +  EV+L DFG+SAQ+  T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198

Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
           V A        Y+   D+WSLGITAIE+AE  PPL D+HP+R LFL+ ++    PRLK K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSK 256

Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
            KWS  F +FI+  L K+  +RP+  +++ H  +      R + + L D +    K    
Sbjct: 257 -KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315

Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
            D  + E            S   SS L +P     RR     +L   E        +L+ 
Sbjct: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375

Query: 361 PRDLRSSSPRKQLSE 375
            +       R+ L+E
Sbjct: 376 QQRENEEHKRQLLAE 390



 Score = 31.2 bits (69), Expect = 4.1
 Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 16/135 (11%)

Query: 513  HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
            +LL+G E G+ +L+R+ Q     ++   R   +  +   NVL+++SGK   L  + +  L
Sbjct: 967  NLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWL 1026

Query: 571  LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
              R        I H  P      K      + D +GC    V +       FL  AL+ +
Sbjct: 1027 RNR--------ILHNDPE---VEKKQGWITVGDLEGCIHYKVVKYERI--KFLVIALKNA 1073

Query: 631  VVLLQWY-QPMNKFL 644
            V +  W  +P +KF+
Sbjct: 1074 VEIYAWAPKPYHKFM 1088


>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
           sapiens]
          Length = 1276

 Score =  244 bits (624), Expect = 2e-64
 Identities = 141/375 (37%), Positives = 210/375 (56%), Gaps = 13/375 (3%)

Query: 11  RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
           RDP   ++L++ +G GTYG+V+K R   +G L A+K++ +  D++    Q+  ++ K   
Sbjct: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH 78

Query: 71  HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
           H NI  Y+G+++         +LW+ MEFCGAGS+ D+ + T   +L E  I+Y+CRE+L
Sbjct: 79  HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138

Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
           +GL++LH  K IHRDIKG N+L+ +  EV+L DFG+SAQ+  T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198

Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
           V A        Y+   D+WSLGITAIE+AE  PPL D+HP+R LFL+ ++    PRLK K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSK 256

Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
            KWS  F +FI+  L K+  +RP+  +++ H  +      R + + L D +    K    
Sbjct: 257 -KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315

Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
            D  + E            S   SS L +P     RR     +L   E        +L+ 
Sbjct: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375

Query: 361 PRDLRSSSPRKQLSE 375
            +       R+ L+E
Sbjct: 376 QQRENEEHKRQLLAE 390



 Score = 31.2 bits (69), Expect = 4.1
 Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 16/135 (11%)

Query: 513  HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
            +LL+G E G+ +L+R+ Q     ++   R   +  +   NVL+++SGK   L  + +  L
Sbjct: 975  NLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWL 1034

Query: 571  LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
              R        I H  P      K      + D +GC    V +       FL  AL+ +
Sbjct: 1035 RNR--------ILHNDPE---VEKKQGWITVGDLEGCIHYKVVKYERI--KFLVIALKNA 1081

Query: 631  VVLLQWY-QPMNKFL 644
            V +  W  +P +KF+
Sbjct: 1082 VEIYAWAPKPYHKFM 1096


>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
           sapiens]
          Length = 1297

 Score =  244 bits (624), Expect = 2e-64
 Identities = 141/375 (37%), Positives = 210/375 (56%), Gaps = 13/375 (3%)

Query: 11  RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
           RDP   ++L++ +G GTYG+V+K R   +G L A+K++ +  D++    Q+  ++ K   
Sbjct: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH 78

Query: 71  HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
           H NI  Y+G+++         +LW+ MEFCGAGS+ D+ + T   +L E  I+Y+CRE+L
Sbjct: 79  HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138

Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
           +GL++LH  K IHRDIKG N+L+ +  EV+L DFG+SAQ+  T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198

Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
           V A        Y+   D+WSLGITAIE+AE  PPL D+HP+R LFL+ ++    PRLK K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSK 256

Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
            KWS  F +FI+  L K+  +RP+  +++ H  +      R + + L D +    K    
Sbjct: 257 -KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315

Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
            D  + E            S   SS L +P     RR     +L   E        +L+ 
Sbjct: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375

Query: 361 PRDLRSSSPRKQLSE 375
            +       R+ L+E
Sbjct: 376 QQRENEEHKRQLLAE 390



 Score = 31.2 bits (69), Expect = 4.1
 Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 16/135 (11%)

Query: 513  HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
            +LL+G E G+ +L+R+ Q     ++   R   +  +   NVL+++SGK   L  + +  L
Sbjct: 996  NLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWL 1055

Query: 571  LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
              R        I H  P      K      + D +GC    V +       FL  AL+ +
Sbjct: 1056 RNR--------ILHNDPE---VEKKQGWITVGDLEGCIHYKVVKYERI--KFLVIALKNA 1102

Query: 631  VVLLQWY-QPMNKFL 644
            V +  W  +P +KF+
Sbjct: 1103 VEIYAWAPKPYHKFM 1117


>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
           sapiens]
          Length = 1305

 Score =  244 bits (624), Expect = 2e-64
 Identities = 141/375 (37%), Positives = 210/375 (56%), Gaps = 13/375 (3%)

Query: 11  RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
           RDP   ++L++ +G GTYG+V+K R   +G L A+K++ +  D++    Q+  ++ K   
Sbjct: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH 78

Query: 71  HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
           H NI  Y+G+++         +LW+ MEFCGAGS+ D+ + T   +L E  I+Y+CRE+L
Sbjct: 79  HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138

Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
           +GL++LH  K IHRDIKG N+L+ +  EV+L DFG+SAQ+  T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198

Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
           V A        Y+   D+WSLGITAIE+AE  PPL D+HP+R LFL+ ++    PRLK K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSK 256

Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
            KWS  F +FI+  L K+  +RP+  +++ H  +      R + + L D +    K    
Sbjct: 257 -KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315

Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
            D  + E            S   SS L +P     RR     +L   E        +L+ 
Sbjct: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375

Query: 361 PRDLRSSSPRKQLSE 375
            +       R+ L+E
Sbjct: 376 QQRENEEHKRQLLAE 390



 Score = 31.2 bits (69), Expect = 4.1
 Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 16/135 (11%)

Query: 513  HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
            +LL+G E G+ +L+R+ Q     ++   R   +  +   NVL+++SGK   L  + +  L
Sbjct: 1004 NLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWL 1063

Query: 571  LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
              R        I H  P      K      + D +GC    V +       FL  AL+ +
Sbjct: 1064 RNR--------ILHNDPE---VEKKQGWITVGDLEGCIHYKVVKYERI--KFLVIALKNA 1110

Query: 631  VVLLQWY-QPMNKFL 644
            V +  W  +P +KF+
Sbjct: 1111 VEIYAWAPKPYHKFM 1125


>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
           sapiens]
          Length = 1323

 Score =  244 bits (624), Expect = 2e-64
 Identities = 141/375 (37%), Positives = 210/375 (56%), Gaps = 13/375 (3%)

Query: 11  RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
           RDP   ++L++ +G GTYG+V+K R   +G L A+K++ +  D++    Q+  ++ K   
Sbjct: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH 78

Query: 71  HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
           H NI  Y+G+++         +LW+ MEFCGAGS+ D+ + T   +L E  I+Y+CRE+L
Sbjct: 79  HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138

Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
           +GL++LH  K IHRDIKG N+L+ +  EV+L DFG+SAQ+  T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198

Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
           V A        Y+   D+WSLGITAIE+AE  PPL D+HP+R LFL+ ++    PRLK K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSK 256

Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
            KWS  F +FI+  L K+  +RP+  +++ H  +      R + + L D +    K    
Sbjct: 257 -KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315

Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
            D  + E            S   SS L +P     RR     +L   E        +L+ 
Sbjct: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375

Query: 361 PRDLRSSSPRKQLSE 375
            +       R+ L+E
Sbjct: 376 QQRENEEHKRQLLAE 390



 Score = 31.2 bits (69), Expect = 4.1
 Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 16/135 (11%)

Query: 513  HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
            +LL+G E G+ +L+R+ Q     ++   R   +  +   NVL+++SGK   L  + +  L
Sbjct: 1022 NLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWL 1081

Query: 571  LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
              R        I H  P      K      + D +GC    V +       FL  AL+ +
Sbjct: 1082 RNR--------ILHNDPE---VEKKQGWITVGDLEGCIHYKVVKYERI--KFLVIALKNA 1128

Query: 631  VVLLQWY-QPMNKFL 644
            V +  W  +P +KF+
Sbjct: 1129 VEIYAWAPKPYHKFM 1143


>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
           sapiens]
          Length = 1331

 Score =  244 bits (624), Expect = 2e-64
 Identities = 141/375 (37%), Positives = 210/375 (56%), Gaps = 13/375 (3%)

Query: 11  RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
           RDP   ++L++ +G GTYG+V+K R   +G L A+K++ +  D++    Q+  ++ K   
Sbjct: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH 78

Query: 71  HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
           H NI  Y+G+++         +LW+ MEFCGAGS+ D+ + T   +L E  I+Y+CRE+L
Sbjct: 79  HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138

Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
           +GL++LH  K IHRDIKG N+L+ +  EV+L DFG+SAQ+  T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198

Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
           V A        Y+   D+WSLGITAIE+AE  PPL D+HP+R LFL+ ++    PRLK K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSK 256

Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
            KWS  F +FI+  L K+  +RP+  +++ H  +      R + + L D +    K    
Sbjct: 257 -KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315

Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
            D  + E            S   SS L +P     RR     +L   E        +L+ 
Sbjct: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375

Query: 361 PRDLRSSSPRKQLSE 375
            +       R+ L+E
Sbjct: 376 QQRENEEHKRQLLAE 390



 Score = 31.2 bits (69), Expect = 4.1
 Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 16/135 (11%)

Query: 513  HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
            +LL+G E G+ +L+R+ Q     ++   R   +  +   NVL+++SGK   L  + +  L
Sbjct: 1030 NLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWL 1089

Query: 571  LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
              R        I H  P      K      + D +GC    V +       FL  AL+ +
Sbjct: 1090 RNR--------ILHNDPE---VEKKQGWITVGDLEGCIHYKVVKYERI--KFLVIALKNA 1136

Query: 631  VVLLQWY-QPMNKFL 644
            V +  W  +P +KF+
Sbjct: 1137 VEIYAWAPKPYHKFM 1151


>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
           sapiens]
          Length = 1352

 Score =  244 bits (624), Expect = 2e-64
 Identities = 141/375 (37%), Positives = 210/375 (56%), Gaps = 13/375 (3%)

Query: 11  RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
           RDP   ++L++ +G GTYG+V+K R   +G L A+K++ +  D++    Q+  ++ K   
Sbjct: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH 78

Query: 71  HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
           H NI  Y+G+++         +LW+ MEFCGAGS+ D+ + T   +L E  I+Y+CRE+L
Sbjct: 79  HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138

Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
           +GL++LH  K IHRDIKG N+L+ +  EV+L DFG+SAQ+  T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198

Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
           V A        Y+   D+WSLGITAIE+AE  PPL D+HP+R LFL+ ++    PRLK K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSK 256

Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
            KWS  F +FI+  L K+  +RP+  +++ H  +      R + + L D +    K    
Sbjct: 257 -KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315

Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
            D  + E            S   SS L +P     RR     +L   E        +L+ 
Sbjct: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375

Query: 361 PRDLRSSSPRKQLSE 375
            +       R+ L+E
Sbjct: 376 QQRENEEHKRQLLAE 390



 Score = 31.2 bits (69), Expect = 4.1
 Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 16/135 (11%)

Query: 513  HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
            +LL+G E G+ +L+R+ Q     ++   R   +  +   NVL+++SGK   L  + +  L
Sbjct: 1051 NLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWL 1110

Query: 571  LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
              R        I H  P      K      + D +GC    V +       FL  AL+ +
Sbjct: 1111 RNR--------ILHNDPE---VEKKQGWITVGDLEGCIHYKVVKYERI--KFLVIALKNA 1157

Query: 631  VVLLQWY-QPMNKFL 644
            V +  W  +P +KF+
Sbjct: 1158 VEIYAWAPKPYHKFM 1172


>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
           sapiens]
          Length = 1360

 Score =  244 bits (624), Expect = 2e-64
 Identities = 141/375 (37%), Positives = 210/375 (56%), Gaps = 13/375 (3%)

Query: 11  RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
           RDP   ++L++ +G GTYG+V+K R   +G L A+K++ +  D++    Q+  ++ K   
Sbjct: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH 78

Query: 71  HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
           H NI  Y+G+++         +LW+ MEFCGAGS+ D+ + T   +L E  I+Y+CRE+L
Sbjct: 79  HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138

Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
           +GL++LH  K IHRDIKG N+L+ +  EV+L DFG+SAQ+  T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198

Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
           V A        Y+   D+WSLGITAIE+AE  PPL D+HP+R LFL+ ++    PRLK K
Sbjct: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSK 256

Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
            KWS  F +FI+  L K+  +RP+  +++ H  +      R + + L D +    K    
Sbjct: 257 -KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315

Query: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
            D  + E            S   SS L +P     RR     +L   E        +L+ 
Sbjct: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375

Query: 361 PRDLRSSSPRKQLSE 375
            +       R+ L+E
Sbjct: 376 QQRENEEHKRQLLAE 390



 Score = 31.2 bits (69), Expect = 4.1
 Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 16/135 (11%)

Query: 513  HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
            +LL+G E G+ +L+R+ Q     ++   R   +  +   NVL+++SGK   L  + +  L
Sbjct: 1059 NLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWL 1118

Query: 571  LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
              R        I H  P      K      + D +GC    V +       FL  AL+ +
Sbjct: 1119 RNR--------ILHNDPE---VEKKQGWITVGDLEGCIHYKVVKYERI--KFLVIALKNA 1165

Query: 631  VVLLQWY-QPMNKFL 644
            V +  W  +P +KF+
Sbjct: 1166 VEIYAWAPKPYHKFM 1180


>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
           sapiens]
          Length = 416

 Score =  244 bits (624), Expect = 2e-64
 Identities = 129/312 (41%), Positives = 195/312 (62%), Gaps = 10/312 (3%)

Query: 12  DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP-DDDVSTLQKEILILKTCR 70
           DP + +  L+R+G G++GEVFK  D  +  +VA+K++ +E  +D++  +Q+EI +L  C 
Sbjct: 19  DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78

Query: 71  HANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 130
            + +  Y+GSYL   KLWI ME+ G GS  D+ +  G   E QI+ + +E+L+GL YLHS
Sbjct: 79  SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHS 137

Query: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190
           +KKIHRDIK AN+L+++ G+V+LADFG++ Q+  T  +R +F+GTP+WMAPEV     + 
Sbjct: 138 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQ---QS 194

Query: 191 GYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNF 250
            Y+   DIWSLGITAIELA+ +PP  D+HP+RVLFL+ K+   PP L   G ++ +F  F
Sbjct: 195 AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKN--NPPTL--VGDFTKSFKEF 250

Query: 251 IKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPEL 310
           I   L K P  RP+A ++L H+ + +       + +L+D+ K   K     D E +    
Sbjct: 251 IDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKR-WKAEGHSDDESDSEGS 309

Query: 311 PPAIPRRIRSTH 322
                 R  +TH
Sbjct: 310 DSESTSRENNTH 321


>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
          Length = 431

 Score =  243 bits (620), Expect = 5e-64
 Identities = 125/299 (41%), Positives = 191/299 (63%), Gaps = 9/299 (3%)

Query: 12  DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP-DDDVSTLQKEILILKTCR 70
           DP + +  L+++G G++GEVFK  D  +  +VA+K++ +E  +D++  +Q+EI +L  C 
Sbjct: 19  DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78

Query: 71  HANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 130
              +  Y+GSYL   KLWI ME+ G GS  D+ +  G L E QI+ + RE+L+GL YLHS
Sbjct: 79  SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE-PGPLDETQIATILREILKGLDYLHS 137

Query: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190
           +KKIHRDIK AN+L+++ GEV+LADFG++ Q+  T  +R +F+GTP+WMAPEV     + 
Sbjct: 138 EKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK---QS 194

Query: 191 GYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNF 250
            Y+   DIWSLGITAIELA  +PP  ++HP++VLFL+ K+   PP L  +G +S     F
Sbjct: 195 AYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKN--NPPTL--EGNYSKPLKEF 250

Query: 251 IKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPE 309
           ++  L K P  RP+A ++L H+ + +       + +L+D+ K      S  D   E+ +
Sbjct: 251 VEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSD 309


>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
          Length = 443

 Score =  243 bits (620), Expect = 5e-64
 Identities = 125/299 (41%), Positives = 191/299 (63%), Gaps = 9/299 (3%)

Query: 12  DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP-DDDVSTLQKEILILKTCR 70
           DP + +  L+++G G++GEVFK  D  +  +VA+K++ +E  +D++  +Q+EI +L  C 
Sbjct: 31  DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90

Query: 71  HANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 130
              +  Y+GSYL   KLWI ME+ G GS  D+ +  G L E QI+ + RE+L+GL YLHS
Sbjct: 91  SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE-PGPLDETQIATILREILKGLDYLHS 149

Query: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190
           +KKIHRDIK AN+L+++ GEV+LADFG++ Q+  T  +R +F+GTP+WMAPEV     + 
Sbjct: 150 EKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK---QS 206

Query: 191 GYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNF 250
            Y+   DIWSLGITAIELA  +PP  ++HP++VLFL+ K+   PP L  +G +S     F
Sbjct: 207 AYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKN--NPPTL--EGNYSKPLKEF 262

Query: 251 IKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPE 309
           ++  L K P  RP+A ++L H+ + +       + +L+D+ K      S  D   E+ +
Sbjct: 263 VEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSD 321


>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
          Length = 1312

 Score =  242 bits (618), Expect = 9e-64
 Identities = 146/375 (38%), Positives = 213/375 (56%), Gaps = 27/375 (7%)

Query: 11  RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
           RDP   ++L++ +G GTYG+V+K R   +G L A+K++ +  D++    Q+  ++ K   
Sbjct: 19  RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSH 78

Query: 71  HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
           H NI  Y+G+++         +LW+ MEFCGAGS+ D+ + T   +L E  I+Y+CRE+L
Sbjct: 79  HRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREIL 138

Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
           +GLA+LH+ K IHRDIKG N+L+ +  EV+L DFG+SAQ+  T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198

Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
           V A        Y+   DIWSLGITAIE+AE  PPL D+HP+R LFL+ ++   PPRLK K
Sbjct: 199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLKSK 256

Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
            KWS  F +FI   L K+   RP   ++L    +      R + + L D +    K    
Sbjct: 257 -KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRG- 314

Query: 301 GDIEDEEPELPPAIPRRIRSTH-----RSSSLGIPDADCCRRHMEFRKLRGMETRPPANT 355
              E EE E   +       +H      SS + +P     RR  EF +L   +    +N+
Sbjct: 315 ---EKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRR--EFLRL---QQENKSNS 366

Query: 356 ARLQPPRDLRSSSPR 370
             L+  + L+    R
Sbjct: 367 EALKQQQQLQQQQQR 381



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 16/135 (11%)

Query: 513  HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
            +LL+G E G+ +L+R+ Q     ++   R   +  +   N+L+++SGK   L  + +  L
Sbjct: 1011 NLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWL 1070

Query: 571  LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
                     N I H  P      K    T + D +GC    V +       FL  AL++S
Sbjct: 1071 --------RNKILHNDPE---VEKKQGWTTVGDMEGCGHYRVVKYERI--KFLVIALKSS 1117

Query: 631  VVLLQWY-QPMNKFL 644
            V +  W  +P +KF+
Sbjct: 1118 VEVYAWAPKPYHKFM 1132


>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
          Length = 1303

 Score =  242 bits (618), Expect = 9e-64
 Identities = 146/375 (38%), Positives = 213/375 (56%), Gaps = 27/375 (7%)

Query: 11  RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
           RDP   ++L++ +G GTYG+V+K R   +G L A+K++ +  D++    Q+  ++ K   
Sbjct: 19  RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSH 78

Query: 71  HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
           H NI  Y+G+++         +LW+ MEFCGAGS+ D+ + T   +L E  I+Y+CRE+L
Sbjct: 79  HRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREIL 138

Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
           +GLA+LH+ K IHRDIKG N+L+ +  EV+L DFG+SAQ+  T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198

Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
           V A        Y+   DIWSLGITAIE+AE  PPL D+HP+R LFL+ ++   PPRLK K
Sbjct: 199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLKSK 256

Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
            KWS  F +FI   L K+   RP   ++L    +      R + + L D +    K    
Sbjct: 257 -KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRG- 314

Query: 301 GDIEDEEPELPPAIPRRIRSTH-----RSSSLGIPDADCCRRHMEFRKLRGMETRPPANT 355
              E EE E   +       +H      SS + +P     RR  EF +L   +    +N+
Sbjct: 315 ---EKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRR--EFLRL---QQENKSNS 366

Query: 356 ARLQPPRDLRSSSPR 370
             L+  + L+    R
Sbjct: 367 EALKQQQQLQQQQQR 381



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 16/135 (11%)

Query: 513  HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
            +LL+G E G+ +L+R+ Q     ++   R   +  +   N+L+++SGK   L  + +  L
Sbjct: 1002 NLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWL 1061

Query: 571  LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
                     N I H  P      K    T + D +GC    V +       FL  AL++S
Sbjct: 1062 --------RNKILHNDPE---VEKKQGWTTVGDMEGCGHYRVVKYERI--KFLVIALKSS 1108

Query: 631  VVLLQWY-QPMNKFL 644
            V +  W  +P +KF+
Sbjct: 1109 VEVYAWAPKPYHKFM 1123


>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
          Length = 1332

 Score =  242 bits (618), Expect = 9e-64
 Identities = 146/375 (38%), Positives = 213/375 (56%), Gaps = 27/375 (7%)

Query: 11  RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
           RDP   ++L++ +G GTYG+V+K R   +G L A+K++ +  D++    Q+  ++ K   
Sbjct: 19  RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSH 78

Query: 71  HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
           H NI  Y+G+++         +LW+ MEFCGAGS+ D+ + T   +L E  I+Y+CRE+L
Sbjct: 79  HRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREIL 138

Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
           +GLA+LH+ K IHRDIKG N+L+ +  EV+L DFG+SAQ+  T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198

Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
           V A        Y+   DIWSLGITAIE+AE  PPL D+HP+R LFL+ ++   PPRLK K
Sbjct: 199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLKSK 256

Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
            KWS  F +FI   L K+   RP   ++L    +      R + + L D +    K    
Sbjct: 257 -KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRG- 314

Query: 301 GDIEDEEPELPPAIPRRIRSTH-----RSSSLGIPDADCCRRHMEFRKLRGMETRPPANT 355
              E EE E   +       +H      SS + +P     RR  EF +L   +    +N+
Sbjct: 315 ---EKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRR--EFLRL---QQENKSNS 366

Query: 356 ARLQPPRDLRSSSPR 370
             L+  + L+    R
Sbjct: 367 EALKQQQQLQQQQQR 381



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 16/135 (11%)

Query: 513  HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
            +LL+G E G+ +L+R+ Q     ++   R   +  +   N+L+++SGK   L  + +  L
Sbjct: 1031 NLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWL 1090

Query: 571  LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
                     N I H  P      K    T + D +GC    V +       FL  AL++S
Sbjct: 1091 --------RNKILHNDPE---VEKKQGWTTVGDMEGCGHYRVVKYERI--KFLVIALKSS 1137

Query: 631  VVLLQWY-QPMNKFL 644
            V +  W  +P +KF+
Sbjct: 1138 VEVYAWAPKPYHKFM 1152


>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
          Length = 1295

 Score =  242 bits (618), Expect = 9e-64
 Identities = 146/375 (38%), Positives = 213/375 (56%), Gaps = 27/375 (7%)

Query: 11  RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
           RDP   ++L++ +G GTYG+V+K R   +G L A+K++ +  D++    Q+  ++ K   
Sbjct: 19  RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSH 78

Query: 71  HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
           H NI  Y+G+++         +LW+ MEFCGAGS+ D+ + T   +L E  I+Y+CRE+L
Sbjct: 79  HRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREIL 138

Query: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
           +GLA+LH+ K IHRDIKG N+L+ +  EV+L DFG+SAQ+  T+ RR +FIGTPYWMAPE
Sbjct: 139 RGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198

Query: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
           V A        Y+   DIWSLGITAIE+AE  PPL D+HP+R LFL+ ++   PPRLK K
Sbjct: 199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLKSK 256

Query: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
            KWS  F +FI   L K+   RP   ++L    +      R + + L D +    K    
Sbjct: 257 -KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRG- 314

Query: 301 GDIEDEEPELPPAIPRRIRSTH-----RSSSLGIPDADCCRRHMEFRKLRGMETRPPANT 355
              E EE E   +       +H      SS + +P     RR  EF +L   +    +N+
Sbjct: 315 ---EKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRR--EFLRL---QQENKSNS 366

Query: 356 ARLQPPRDLRSSSPR 370
             L+  + L+    R
Sbjct: 367 EALKQQQQLQQQQQR 381



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 16/135 (11%)

Query: 513  HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
            +LL+G E G+ +L+R+ Q     ++   R   +  +   N+L+++SGK   L  + +  L
Sbjct: 994  NLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWL 1053

Query: 571  LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
                     N I H  P      K    T + D +GC    V +       FL  AL++S
Sbjct: 1054 --------RNKILHNDPE---VEKKQGWTTVGDMEGCGHYRVVKYERI--KFLVIALKSS 1100

Query: 631  VVLLQWY-QPMNKFL 644
            V +  W  +P +KF+
Sbjct: 1101 VEVYAWAPKPYHKFM 1115


>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
          Length = 426

 Score =  242 bits (618), Expect = 9e-64
 Identities = 123/282 (43%), Positives = 188/282 (66%), Gaps = 9/282 (3%)

Query: 12  DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP-DDDVSTLQKEILILKTCR 70
           DP + +  L R+G G++GEV+K  D  + ++VA+K++ +E  +D++  +Q+EI +L  C 
Sbjct: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74

Query: 71  HANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 130
              I  Y GSYL   KLWI ME+ G GS  D+ +  G L E  I+ + RE+L+GL YLHS
Sbjct: 75  SPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK-PGPLEETYIATILREILKGLDYLHS 133

Query: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190
           ++KIHRDIK AN+L+++ G+V+LADFG++ Q+  T  +R +F+GTP+WMAPEV     + 
Sbjct: 134 ERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK---QS 190

Query: 191 GYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNF 250
            Y+   DIWSLGITAIELA+ +PP  D+HP+RVLFL+ K+   PP L  +G+ S  F  F
Sbjct: 191 AYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKN--SPPTL--EGQHSKPFKEF 246

Query: 251 IKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLK 292
           ++  L K P+ RP+A ++L H+ +++       + +L+D+ K
Sbjct: 247 VEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYK 288


>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
          Length = 491

 Score =  241 bits (614), Expect = 3e-63
 Identities = 128/305 (41%), Positives = 194/305 (63%), Gaps = 12/305 (3%)

Query: 7   DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 66
           D   + P + +D+L++LG G+YG VFKA  K SG +VA+K V +E   D+  + KEI I+
Sbjct: 17  DSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE--SDLQEIIKEISIM 74

Query: 67  KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG-SLSELQISYVCREVLQGL 125
           + C    +V Y+GSY     LWI ME+CGAGS+ DI ++   +L E +I+ + +  L+GL
Sbjct: 75  QQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGL 134

Query: 126 AYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAA 185
            YLH  +KIHRDIK  NIL+N  G  +LADFG++ Q+  T+A+R + IGTP+WMAPEV  
Sbjct: 135 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 194

Query: 186 VALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSA 245
              + GYN + DIWSLGIT+IE+AE +PP  D+HP+R +F++  +   PP  ++   WS 
Sbjct: 195 ---EIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPELWSD 249

Query: 246 AFHNFIKVTLTKSPKKRPSATKMLSHQLVSQP---GLNRGLILDLLDKLKNPGKGPSIGD 302
            F +F+K  L K+P++R +AT++L H  +       + R LI + ++ +K         +
Sbjct: 250 DFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAME-IKAKRHEEQQRE 308

Query: 303 IEDEE 307
           +E+EE
Sbjct: 309 LEEEE 313


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 3 [Homo sapiens]
          Length = 1212

 Score =  239 bits (609), Expect = 1e-62
 Identities = 145/389 (37%), Positives = 215/389 (55%), Gaps = 28/389 (7%)

Query: 3   VVDPDIFN-RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQK 61
           +VD D+ + RDP   ++L++ +G GTYG+V+K R   +G L A+K++ +  D++     +
Sbjct: 10  LVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLE 69

Query: 62  EILILKTCRHANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQ 113
             ++ K   H NI  Y+G+++         +LW+ MEFCGAGS+ D+ + T   +L E  
Sbjct: 70  INMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDW 129

Query: 114 ISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFI 173
           I+Y+ RE+L+GLA+LH    IHRDIKG N+L+ +  EV+L DFG+SAQ+  T+ RR +FI
Sbjct: 130 IAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189

Query: 174 GTPYWMAPEVAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSG 231
           GTPYWMAPEV A        Y+   D+WS GITAIE+AE  PPL D+HP+R LFL+ ++ 
Sbjct: 190 GTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN- 248

Query: 232 YQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKL 291
             PPRLK K KWS  F +FI+  L K+  +RPS  ++L H  +      R + + L D +
Sbjct: 249 -PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHI 306

Query: 292 KNPGKGPSIGD--------IEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRK 343
               K     D         E+EE E+P       +    SS + +P     RR     +
Sbjct: 307 DRTRKKRGEKDETEYEYSGSEEEEEEVPE------QEGEPSSIVNVPGESTLRRDFLRLQ 360

Query: 344 LRGMETRPPANTARLQPPRDLRSSSPRKQ 372
               E        +L   + LR     K+
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKR 389



 Score = 34.7 bits (78), Expect = 0.37
 Identities = 37/135 (27%), Positives = 61/135 (45%), Gaps = 16/135 (11%)

Query: 513  HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
            +LL+G E G+ +L+R+ Q     ++   R   +  +   NVL+++SGK   L  + +  L
Sbjct: 911  NLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWL 970

Query: 571  LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
                     N I H  P      K    T + D +GC    V +       FL  AL++S
Sbjct: 971  --------RNKILHNDPE---VEKKQGWTTVGDLEGCVHYKVVKYERI--KFLVIALKSS 1017

Query: 631  VVLLQWY-QPMNKFL 644
            V +  W  +P +KF+
Sbjct: 1018 VEVYAWAPKPYHKFM 1032


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score =  239 bits (609), Expect = 1e-62
 Identities = 145/389 (37%), Positives = 215/389 (55%), Gaps = 28/389 (7%)

Query: 3   VVDPDIFN-RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQK 61
           +VD D+ + RDP   ++L++ +G GTYG+V+K R   +G L A+K++ +  D++     +
Sbjct: 10  LVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLE 69

Query: 62  EILILKTCRHANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQ 113
             ++ K   H NI  Y+G+++         +LW+ MEFCGAGS+ D+ + T   +L E  
Sbjct: 70  INMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDW 129

Query: 114 ISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFI 173
           I+Y+ RE+L+GLA+LH    IHRDIKG N+L+ +  EV+L DFG+SAQ+  T+ RR +FI
Sbjct: 130 IAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189

Query: 174 GTPYWMAPEVAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSG 231
           GTPYWMAPEV A        Y+   D+WS GITAIE+AE  PPL D+HP+R LFL+ ++ 
Sbjct: 190 GTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN- 248

Query: 232 YQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKL 291
             PPRLK K KWS  F +FI+  L K+  +RPS  ++L H  +      R + + L D +
Sbjct: 249 -PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHI 306

Query: 292 KNPGKGPSIGD--------IEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRK 343
               K     D         E+EE E+P       +    SS + +P     RR     +
Sbjct: 307 DRTRKKRGEKDETEYEYSGSEEEEEEVPE------QEGEPSSIVNVPGESTLRRDFLRLQ 360

Query: 344 LRGMETRPPANTARLQPPRDLRSSSPRKQ 372
               E        +L   + LR     K+
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKR 389



 Score = 34.7 bits (78), Expect = 0.37
 Identities = 37/135 (27%), Positives = 61/135 (45%), Gaps = 16/135 (11%)

Query: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
           +LL+G E G+ +L+R+ Q     ++   R   +  +   NVL+++SGK   L  + +  L
Sbjct: 857 NLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWL 916

Query: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
                    N I H  P      K    T + D +GC    V +       FL  AL++S
Sbjct: 917 --------RNKILHNDPE---VEKKQGWTTVGDLEGCVHYKVVKYERI--KFLVIALKSS 963

Query: 631 VVLLQWY-QPMNKFL 644
           V +  W  +P +KF+
Sbjct: 964 VEVYAWAPKPYHKFM 978


>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 2 [Homo sapiens]
          Length = 1320

 Score =  239 bits (609), Expect = 1e-62
 Identities = 145/389 (37%), Positives = 215/389 (55%), Gaps = 28/389 (7%)

Query: 3   VVDPDIFN-RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQK 61
           +VD D+ + RDP   ++L++ +G GTYG+V+K R   +G L A+K++ +  D++     +
Sbjct: 10  LVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLE 69

Query: 62  EILILKTCRHANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQ 113
             ++ K   H NI  Y+G+++         +LW+ MEFCGAGS+ D+ + T   +L E  
Sbjct: 70  INMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDW 129

Query: 114 ISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFI 173
           I+Y+ RE+L+GLA+LH    IHRDIKG N+L+ +  EV+L DFG+SAQ+  T+ RR +FI
Sbjct: 130 IAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189

Query: 174 GTPYWMAPEVAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSG 231
           GTPYWMAPEV A        Y+   D+WS GITAIE+AE  PPL D+HP+R LFL+ ++ 
Sbjct: 190 GTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN- 248

Query: 232 YQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKL 291
             PPRLK K KWS  F +FI+  L K+  +RPS  ++L H  +      R + + L D +
Sbjct: 249 -PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHI 306

Query: 292 KNPGKGPSIGD--------IEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRK 343
               K     D         E+EE E+P       +    SS + +P     RR     +
Sbjct: 307 DRTRKKRGEKDETEYEYSGSEEEEEEVPE------QEGEPSSIVNVPGESTLRRDFLRLQ 360

Query: 344 LRGMETRPPANTARLQPPRDLRSSSPRKQ 372
               E        +L   + LR     K+
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKR 389



 Score = 34.7 bits (78), Expect = 0.37
 Identities = 37/135 (27%), Positives = 61/135 (45%), Gaps = 16/135 (11%)

Query: 513  HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
            +LL+G E G+ +L+R+ Q     ++   R   +  +   NVL+++SGK   L  + +  L
Sbjct: 1019 NLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWL 1078

Query: 571  LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
                     N I H  P      K    T + D +GC    V +       FL  AL++S
Sbjct: 1079 --------RNKILHNDPE---VEKKQGWTTVGDLEGCVHYKVVKYERI--KFLVIALKSS 1125

Query: 631  VVLLQWY-QPMNKFL 644
            V +  W  +P +KF+
Sbjct: 1126 VEVYAWAPKPYHKFM 1140


>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
          Length = 968

 Score =  236 bits (602), Expect = 6e-62
 Identities = 142/370 (38%), Positives = 212/370 (57%), Gaps = 19/370 (5%)

Query: 12  DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRH 71
           DP + ++++  LG G +G+V+KA++K +G L A K+++ + ++++     EI IL TC H
Sbjct: 31  DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90

Query: 72  ANIVAYHGSYLWLQKLWICMEFCGAGSLQDIY-QVTGSLSELQISYVCREVLQGLAYLHS 130
             IV   G+Y    KLWI +EFC  G++  I  ++   L+E QI  VCR++L+ L +LHS
Sbjct: 91  PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHS 150

Query: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190
           ++ IHRD+K  N+L+   G++RLADFG+SA+   TL +R SFIGTPYWMAPEV       
Sbjct: 151 KRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMK 210

Query: 191 G--YNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFH 248
              Y+   DIWSLGIT IE+A+++PP  +++P+RVL  + KS   PP L    KWS  F 
Sbjct: 211 DTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKS--DPPTLLTPSKWSVEFR 268

Query: 249 NFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIED--- 305
           +F+K+ L K+P+ RPSA ++L H  VS    N+      L +L    K   + +IED   
Sbjct: 269 DFLKIALDKNPETRPSAAQLLEHPFVSSITSNKA-----LRELVAEAKAEVMEEIEDGRD 323

Query: 306 --EEPELPPAIPRRIRSTHRSSSLGIP--DADCCRRHMEFRKLRGMETRPPANTARLQP- 360
             EE +   A       T  SS +  P  +AD          L   +++   N    QP 
Sbjct: 324 EGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPS 383

Query: 361 -PRDLRSSSP 369
             R L+++SP
Sbjct: 384 GDRSLQTTSP 393


>gi|145275208 myosin IIIA [Homo sapiens]
          Length = 1616

 Score =  218 bits (554), Expect = 2e-56
 Identities = 120/280 (42%), Positives = 175/280 (62%), Gaps = 21/280 (7%)

Query: 12  DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVST-LQKEILILKTCR 70
           DP D +++ + +G GTYG+VFK  +K +G   A+K+  ++P  D+   ++ E  ILK   
Sbjct: 16  DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKI--LDPIHDIDEEIEAEYNILKALS 73

Query: 71  -HANIVAYHGSYLWLQK-----LWICMEFCGAGSLQDIYQVTGSL------SELQISYVC 118
            H N+V ++G Y    K     LW+ +E C  GS+ D+  V G L      SE  I+Y+ 
Sbjct: 74  DHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDL--VKGFLKRGERMSEPLIAYIL 131

Query: 119 REVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYW 178
            E L GL +LH+ K IHRD+KG NIL+   G V+L DFG+SAQ+ +T  RR + +GTP+W
Sbjct: 132 HEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFW 191

Query: 179 MAPEVAAV--ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPR 236
           MAPEV A    L   Y+  CD WSLGITAIEL +  PPL D+HP+R LF + ++   PP+
Sbjct: 192 MAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRN--PPPK 249

Query: 237 LKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQ 276
           L++   WSA F++FI   LTK  +KRP+ +++L H+ ++Q
Sbjct: 250 LRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQ 289


>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
          Length = 1235

 Score =  216 bits (549), Expect = 9e-56
 Identities = 119/318 (37%), Positives = 190/318 (59%), Gaps = 8/318 (2%)

Query: 12  DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRH 71
           +P D ++++  LG G +G+V+KA++K +  L A K++  + ++++     EI IL +C H
Sbjct: 29  NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88

Query: 72  ANIVAYHGSYLWLQKLWICMEFCGAGSLQDIY-QVTGSLSELQISYVCREVLQGLAYLHS 130
            NIV    ++ +   LWI +EFC  G++  +  ++   L+E QI  VC++ L  L YLH 
Sbjct: 89  PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD 148

Query: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEV--AAVAL 188
            K IHRD+K  NIL    G+++LADFG+SA+   T+ RR SFIGTPYWMAPEV     + 
Sbjct: 149 NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSK 208

Query: 189 KGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFH 248
              Y+   D+WSLGIT IE+AE++PP  +++P+RVL  + KS  +PP L +  +WS+ F 
Sbjct: 209 DRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKS--EPPTLAQPSRWSSNFK 266

Query: 249 NFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEP 308
           +F+K  L K+   R + +++L H  V+    N+ +   + +      +    G  EDEE 
Sbjct: 267 DFLKKCLEKNVDARWTTSQLLQHPFVTVDS-NKPIRELIAEAKAEVTEEVEDGKEEDEEE 325

Query: 309 ELPPAIPRRIRSTHRSSS 326
           E   ++P  I ++ R+SS
Sbjct: 326 ETENSLP--IPASKRASS 341


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.137    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,046,802
Number of Sequences: 37866
Number of extensions: 2292921
Number of successful extensions: 19828
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 788
Number of HSP's successfully gapped in prelim test: 862
Number of HSP's that attempted gapping in prelim test: 12061
Number of HSP's gapped (non-prelim): 5334
length of query: 821
length of database: 18,247,518
effective HSP length: 111
effective length of query: 710
effective length of database: 14,044,392
effective search space: 9971518320
effective search space used: 9971518320
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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