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Search of human proteins with 110611218
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110611218 ribosome binding protein 1 [Homo sapiens]
(977 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110611218 ribosome binding protein 1 [Homo sapiens] 1853 0.0
gi|110611220 ribosome binding protein 1 [Homo sapiens] 1853 0.0
gi|118498356 kinectin 1 isoform a [Homo sapiens] 265 2e-70
gi|33620775 kinectin 1 isoform a [Homo sapiens] 265 2e-70
gi|118498362 kinectin 1 isoform b [Homo sapiens] 239 1e-62
gi|118498368 kinectin 1 isoform c [Homo sapiens] 234 3e-61
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 157 4e-38
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 143 9e-34
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 139 1e-32
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 139 2e-32
gi|156104908 myosin heavy chain 6 [Homo sapiens] 138 3e-32
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 135 2e-31
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 134 4e-31
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 134 4e-31
gi|38044112 restin isoform b [Homo sapiens] 133 7e-31
gi|4506751 restin isoform a [Homo sapiens] 132 1e-30
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 132 1e-30
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 132 1e-30
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 132 1e-30
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 132 1e-30
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 132 1e-30
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 132 1e-30
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 132 1e-30
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 132 1e-30
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 129 1e-29
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 129 1e-29
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 127 4e-29
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 127 4e-29
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 127 4e-29
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 127 4e-29
>gi|110611218 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 1853 bits (4799), Expect = 0.0
Identities = 977/977 (100%), Positives = 977/977 (100%)
Query: 1 MDIYDTQTLGVVVFGGFMVVSAIGIFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKK 60
MDIYDTQTLGVVVFGGFMVVSAIGIFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKK
Sbjct: 1 MDIYDTQTLGVVVFGGFMVVSAIGIFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKK 60
Query: 61 KKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAP 120
KKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAP
Sbjct: 61 KKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAP 120
Query: 121 VATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNT 180
VATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNT
Sbjct: 121 VATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNT 180
Query: 181 DVAQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEI 240
DVAQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEI
Sbjct: 181 DVAQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEI 240
Query: 241 LSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAE 300
LSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAE
Sbjct: 241 LSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAE 300
Query: 301 KAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNT 360
KAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNT
Sbjct: 301 KAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNT 360
Query: 361 QLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRK 420
QLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRK
Sbjct: 361 QLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRK 420
Query: 421 ALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQ 480
ALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQ
Sbjct: 421 ALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQ 480
Query: 481 QMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQ 540
QMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQ
Sbjct: 481 QMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQ 540
Query: 541 DVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALAT 600
DVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALAT
Sbjct: 541 DVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALAT 600
Query: 601 AEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKG 660
AEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKG
Sbjct: 601 AEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKG 660
Query: 661 PTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEE 720
PTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEE
Sbjct: 661 PTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEE 720
Query: 721 QVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAAS 780
QVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAAS
Sbjct: 721 QVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAAS 780
Query: 781 AECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGA 840
AECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGA
Sbjct: 781 AECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGA 840
Query: 841 PASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLR 900
PASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLR
Sbjct: 841 PASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLR 900
Query: 901 TAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQE 960
TAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQE
Sbjct: 901 TAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQE 960
Query: 961 QLEKAEDGSSSKEGTSV 977
QLEKAEDGSSSKEGTSV
Sbjct: 961 QLEKAEDGSSSKEGTSV 977
>gi|110611220 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 1853 bits (4799), Expect = 0.0
Identities = 977/977 (100%), Positives = 977/977 (100%)
Query: 1 MDIYDTQTLGVVVFGGFMVVSAIGIFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKK 60
MDIYDTQTLGVVVFGGFMVVSAIGIFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKK
Sbjct: 1 MDIYDTQTLGVVVFGGFMVVSAIGIFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKK 60
Query: 61 KKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAP 120
KKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAP
Sbjct: 61 KKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAP 120
Query: 121 VATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNT 180
VATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNT
Sbjct: 121 VATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNT 180
Query: 181 DVAQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEI 240
DVAQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEI
Sbjct: 181 DVAQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEI 240
Query: 241 LSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAE 300
LSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAE
Sbjct: 241 LSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAE 300
Query: 301 KAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNT 360
KAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNT
Sbjct: 301 KAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNT 360
Query: 361 QLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRK 420
QLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRK
Sbjct: 361 QLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRK 420
Query: 421 ALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQ 480
ALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQ
Sbjct: 421 ALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQ 480
Query: 481 QMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQ 540
QMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQ
Sbjct: 481 QMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQ 540
Query: 541 DVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALAT 600
DVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALAT
Sbjct: 541 DVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALAT 600
Query: 601 AEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKG 660
AEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKG
Sbjct: 601 AEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKG 660
Query: 661 PTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEE 720
PTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEE
Sbjct: 661 PTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEE 720
Query: 721 QVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAAS 780
QVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAAS
Sbjct: 721 QVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAAS 780
Query: 781 AECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGA 840
AECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGA
Sbjct: 781 AECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGA 840
Query: 841 PASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLR 900
PASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLR
Sbjct: 841 PASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLR 900
Query: 901 TAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQE 960
TAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQE
Sbjct: 901 TAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQE 960
Query: 961 QLEKAEDGSSSKEGTSV 977
QLEKAEDGSSSKEGTSV
Sbjct: 961 QLEKAEDGSSSKEGTSV 977
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 265 bits (676), Expect = 2e-70
Identities = 223/804 (27%), Positives = 382/804 (47%), Gaps = 126/804 (15%)
Query: 234 AQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLE-----------EKEKLLATEQED 282
A+ L ++++EK I+ T + D + + +L+ E +KL A E
Sbjct: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQ 661
Query: 283 AAVAKS-------------KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
AA A K+R L +++ E + + Q A + E+ +Q +
Sbjct: 662 AAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLV 721
Query: 330 QASYREHVKE-----VQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVE 384
+ V E +Q+ K++T++E LE G Q+A ++E + +R + T +V+
Sbjct: 722 SEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGL-IQVATKEEELNAIRTENSSLTKEVQ 780
Query: 385 ---SKQNAEL--AKLRQELSKVSKE------------------LVEKSEAVRQDEQQRKA 421
+KQN ++ A L +EL KV E + K + V+ +Q+ KA
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
Query: 422 LE----------AKAAAFEKQVLQLQASHRESEEALQKR---LDEVSRELCHT------- 461
L+ A+ + +V +LQ + EE + L+E ++L +T
Sbjct: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
Query: 462 QSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLT 521
Q + SL+A ++ + + A S+ + E ++ K EL L L+E ++ S T
Sbjct: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
Query: 522 ERIRSI--EALLEAGQARDAQDVQASQAEADQQQTRL----KELESQVSGLEKEAIELRE 575
+ ++ + E L Q + QA + L E E ++SGL E L++
Sbjct: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
Query: 576 AVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALL 635
AVE Q+ KNNDLREKNW+AMEALA+ E+ ++K++ + +E ++Q+ +E + E L
Sbjct: 1021 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVN---KTSKERQQQVEAVELEAKEVLK 1077
Query: 636 ALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAEC 695
L P++SV + +Y EWL ++K + +E L KL+EA+E + LQ EC
Sbjct: 1078 KLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG-SEEVKVLEHKLKEADEMHTLLQLEC 1136
Query: 696 DQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGEL 755
++Y+S+LAETEG+L+ LQ+SVE+EE W+ KV + + +++ + + E+ +E+L+ E
Sbjct: 1137 EKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSEN 1196
Query: 756 ESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQS 815
+ + +R HLE ELEK A E Y EV L+ LL E Q +LD + SEA +Q+
Sbjct: 1197 KDIENLRREREHLEMELEK----AEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQN 1252
Query: 816 DELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQR 875
+EL L++ QL+E T L EQ +R
Sbjct: 1253 EELNLLKAQLNE------------------------------------TLTKLRTEQNER 1276
Query: 876 QKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAAT 935
QK+ + +AQ S +Q ++ ++ AG E + S E EKE ++ L + T
Sbjct: 1277 QKVAGDLHKAQQSLELIQSKI--VKAAGDTTVIENSDVSPETESSEKE-TMSVSLNQTVT 1333
Query: 936 RLQELLKTTQEQLAREKDTVKKLQ 959
+LQ+LL+ +QL +EK+ + L+
Sbjct: 1334 QLQQLLQAVNQQLTKEKEHYQVLE 1357
Score = 238 bits (607), Expect = 2e-62
Identities = 262/1095 (23%), Positives = 481/1095 (43%), Gaps = 199/1095 (18%)
Query: 25 IFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKI- 83
IFL MKET Y+E LA Q++E K K +KKK EK K KK+E NG +
Sbjct: 21 IFLFFWLFMKETLYDEVLAKQKREQ-KLIPTKTDKKKAEK------KKNKKKEIQNGNLH 73
Query: 84 -PDHDPAPNVTVLLREPVRAPAVAVAPTPV------------------QPPIIV------ 118
D + P L + + VAP P+ Q P++
Sbjct: 74 ESDSESVPR-DFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKE 132
Query: 119 -------------APVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTS 165
PV P P E AS K +KK K + + V ++ V +
Sbjct: 133 SDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQ---DKKVETLMVPSK 189
Query: 166 KAAIL----ETAPKEGRNTDVAQS------------------------------PEAPKQ 191
+ L ET + G A S P K+
Sbjct: 190 RQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKR 249
Query: 192 EA---------PAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILS 242
E +KSG+KK + +K + ++ +M+F+E EA ++++L
Sbjct: 250 EVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK 309
Query: 243 EKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKA 302
EK+G+IQD K++ KG+ ++ QL+EK+KLLA +EDAA K + ++L +EM EK
Sbjct: 310 EKSGVIQDALKKSS-KGELTTLI-HQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE 367
Query: 303 KAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQL 362
++ ++K ++ E+E Q ++ SY+E QQ+Q K + ++EQ+E ++
Sbjct: 368 RSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE----TQQMQMKFQQVREQME----AEI 419
Query: 363 ARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
A L+QEN ILRDA++ T+Q+ESKQ+AEL KLRQ+ +++ EL EK+ ++Q+E Q+K
Sbjct: 420 AHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNA 479
Query: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDE------------VSRELCHTQSSHASLRA 470
E A + Q+ + + E + ++KR E V++E QS H+ L
Sbjct: 480 EQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKEN-EVQSLHSKLTD 538
Query: 471 DAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEAL 530
Q+ +Q++ +L ++S + V + L Q+Q+ +N L +I+ +
Sbjct: 539 TLVSKQQLEQRLMQL---MESEQKRVNKE----ESLQMQVQDILEQNEALKAQIQQFHSQ 591
Query: 531 LEAGQARD--AQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLR 588
+ A + A+++ AE D+Q +K+ E ++ E++ + +E + N L
Sbjct: 592 IAAQTSASVLAEELHKVIAEKDKQ---IKQTEDSLAS-ERDRLTSKEEELKDIQNMNFLL 647
Query: 589 EKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQN 648
+ + ++ALA + A +L + Q+ + ++ L+E Q + + E +L QN
Sbjct: 648 KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707
Query: 649 YTEWLQDLKEKGPTLLKHPPAP------AEPSSDLASKLREAEETQST----LQAECDQY 698
L+ +K TL+ P + + KL+ EE T + + ++
Sbjct: 708 KA--LKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEEL 765
Query: 699 RSILAETEGMLRDLQ-------------KSVEEEEQVWRAKVG---AAEEELQKSRVTVK 742
+I E + +++Q VEE ++V K G + EE L+ + V
Sbjct: 766 NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVA 825
Query: 743 HLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQS 802
+ E+ V+ LK E+++ ++E +++ E + ++ S +V L+ LL +
Sbjct: 826 NKEKTVQDLKQEIKA---LKEEIGNVQLEKAQQLSITS--------KVQELQNLLKGKEE 874
Query: 803 QLDAAKSEAQKQSDELALVRQQLSEM-------KSHVEDGDIAGAPASSPEAPPAEQDPV 855
Q++ K+ +++ +LA + L ++ K+HV++ +S + E + V
Sbjct: 875 QMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIV 934
Query: 856 --QLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSET--- 910
+ + +L+ EA+L++ ++ T ++ Q + ++E+L+ ++S
Sbjct: 935 LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPH 994
Query: 911 ------------------EEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLA-RE 951
E LK+ +E ++K +DL E L +T++ L +
Sbjct: 995 EELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKV 1054
Query: 952 KDTVKKLQEQLEKAE 966
T K+ Q+Q+E E
Sbjct: 1055 NKTSKERQQQVEAVE 1069
Score = 100 bits (250), Expect = 5e-21
Identities = 173/853 (20%), Positives = 348/853 (40%), Gaps = 169/853 (19%)
Query: 236 RLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNK 295
RL+ L+EK G +Q + LK QL+E E+ + E+
Sbjct: 457 RLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAER--------------RWEEVQS 502
Query: 296 EMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLE 355
+ A+ A + ++ + VA+E E+ ++ +++ + + QQL+ ++ L E +
Sbjct: 503 YIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLT----DTLVSKQQLEQRLMQLMESEQ 558
Query: 356 NGPNT------QLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKS 409
N Q+ + ++N L+ + Q SQ+ ++ +A + L +EL KV + EK
Sbjct: 559 KRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV--LAEELHKV---IAEKD 613
Query: 410 EAVRQDEQ---------------------------------QRKALEAKAAAFEKQVLQL 436
+ ++Q E Q A E AAA E + +Q
Sbjct: 614 KQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQ 673
Query: 437 QASHRES-----EEALQKRLDEVSRELCHTQSSHASLRADAEKAQ-------------EQ 478
++ EE LQ + E + +L+++ +K Q +
Sbjct: 674 SVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQM 733
Query: 479 QQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARD 538
++ + E KL++ E + + +++ +L R ENS LT+ ++ ++A + Q
Sbjct: 734 EKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK-QNDQVSF 792
Query: 539 AQDVQASQAEADQQQTRLKELES-------QVSGLEKEAIELREAVEQQKVKNNDLREKN 591
A V+ + ++ ++K +E +V+ EK +L++ ++ K + +++ +
Sbjct: 793 ASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE- 851
Query: 592 WKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTE 651
KA + T++ ++L +L + KEE + TM+A+L E N +
Sbjct: 852 -KAQQLSITSKV---QELQNLLKGKEE--------QMNTMKAVL----EEKEKDLANTGK 895
Query: 652 WLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQA---ECDQYRSILAETEGM 708
WLQDL+E+ +L H A+ + AS + EE + L+ E + ++L E E
Sbjct: 896 WLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESD 955
Query: 709 LRD---LQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLK----------GEL 755
L L + V++E +++++++ +++ + + EE+++ + EL
Sbjct: 956 LSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNEL 1015
Query: 756 ESSDQVREHTSHLEAEL-EKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQ 814
+S EH +L EK+ A A + + E Q Q++A + EA++
Sbjct: 1016 DSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEV 1075
Query: 815 SDELALVRQQLSEMKSHVEDGD------------IAGAPASSP----EAPPAEQDPVQLK 858
+L + S++ G+ +AG S E E D +
Sbjct: 1076 LKKLF----PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTL 1131
Query: 859 TQLEW---------TEAILE------DEQTQRQKLTAE-----FEEAQTSACRLQEELEK 898
QLE TE IL+ +++ + K+ + ++ Q+S ++ELE+
Sbjct: 1132 LQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELER 1191
Query: 899 LRTAGPLESSETEEASQLKERLEKEKKLTS-------DLGRAATRLQELLKTTQEQLARE 951
LR+ + E L+ LEK + S +L T LQ+ L + + R+
Sbjct: 1192 LRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQ 1251
Query: 952 KDTVKKLQEQLEK 964
+ + L+ QL +
Sbjct: 1252 NEELNLLKAQLNE 1264
Score = 41.2 bits (95), Expect = 0.005
Identities = 30/124 (24%), Positives = 60/124 (48%), Gaps = 5/124 (4%)
Query: 233 EAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRE 292
E + L ++L+E + D++ +A ++ + + +LK QL E L TEQ + L +
Sbjct: 1226 EVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHK 1285
Query: 293 LNK--EMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTL 350
+ E+ K AAG+ V + + ++ + M S + V ++QQL ++ +
Sbjct: 1286 AQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQL---LQAV 1342
Query: 351 QEQL 354
+QL
Sbjct: 1343 NQQL 1346
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 265 bits (676), Expect = 2e-70
Identities = 223/804 (27%), Positives = 382/804 (47%), Gaps = 126/804 (15%)
Query: 234 AQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLE-----------EKEKLLATEQED 282
A+ L ++++EK I+ T + D + + +L+ E +KL A E
Sbjct: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQ 661
Query: 283 AAVAKS-------------KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
AA A K+R L +++ E + + Q A + E+ +Q +
Sbjct: 662 AAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLV 721
Query: 330 QASYREHVKE-----VQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVE 384
+ V E +Q+ K++T++E LE G Q+A ++E + +R + T +V+
Sbjct: 722 SEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGL-IQVATKEEELNAIRTENSSLTKEVQ 780
Query: 385 ---SKQNAEL--AKLRQELSKVSKE------------------LVEKSEAVRQDEQQRKA 421
+KQN ++ A L +EL KV E + K + V+ +Q+ KA
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
Query: 422 LE----------AKAAAFEKQVLQLQASHRESEEALQKR---LDEVSRELCHT------- 461
L+ A+ + +V +LQ + EE + L+E ++L +T
Sbjct: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
Query: 462 QSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLT 521
Q + SL+A ++ + + A S+ + E ++ K EL L L+E ++ S T
Sbjct: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
Query: 522 ERIRSI--EALLEAGQARDAQDVQASQAEADQQQTRL----KELESQVSGLEKEAIELRE 575
+ ++ + E L Q + QA + L E E ++SGL E L++
Sbjct: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
Query: 576 AVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALL 635
AVE Q+ KNNDLREKNW+AMEALA+ E+ ++K++ + +E ++Q+ +E + E L
Sbjct: 1021 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVN---KTSKERQQQVEAVELEAKEVLK 1077
Query: 636 ALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAEC 695
L P++SV + +Y EWL ++K + +E L KL+EA+E + LQ EC
Sbjct: 1078 KLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG-SEEVKVLEHKLKEADEMHTLLQLEC 1136
Query: 696 DQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGEL 755
++Y+S+LAETEG+L+ LQ+SVE+EE W+ KV + + +++ + + E+ +E+L+ E
Sbjct: 1137 EKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSEN 1196
Query: 756 ESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQS 815
+ + +R HLE ELEK A E Y EV L+ LL E Q +LD + SEA +Q+
Sbjct: 1197 KDIENLRREREHLEMELEK----AEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQN 1252
Query: 816 DELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQR 875
+EL L++ QL+E T L EQ +R
Sbjct: 1253 EELNLLKAQLNE------------------------------------TLTKLRTEQNER 1276
Query: 876 QKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAAT 935
QK+ + +AQ S +Q ++ ++ AG E + S E EKE ++ L + T
Sbjct: 1277 QKVAGDLHKAQQSLELIQSKI--VKAAGDTTVIENSDVSPETESSEKE-TMSVSLNQTVT 1333
Query: 936 RLQELLKTTQEQLAREKDTVKKLQ 959
+LQ+LL+ +QL +EK+ + L+
Sbjct: 1334 QLQQLLQAVNQQLTKEKEHYQVLE 1357
Score = 238 bits (607), Expect = 2e-62
Identities = 262/1095 (23%), Positives = 481/1095 (43%), Gaps = 199/1095 (18%)
Query: 25 IFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKI- 83
IFL MKET Y+E LA Q++E K K +KKK EK K KK+E NG +
Sbjct: 21 IFLFFWLFMKETLYDEVLAKQKREQ-KLIPTKTDKKKAEK------KKNKKKEIQNGNLH 73
Query: 84 -PDHDPAPNVTVLLREPVRAPAVAVAPTPV------------------QPPIIV------ 118
D + P L + + VAP P+ Q P++
Sbjct: 74 ESDSESVPR-DFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKE 132
Query: 119 -------------APVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTS 165
PV P P E AS K +KK K + + V ++ V +
Sbjct: 133 SDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQ---DKKVETLMVPSK 189
Query: 166 KAAIL----ETAPKEGRNTDVAQS------------------------------PEAPKQ 191
+ L ET + G A S P K+
Sbjct: 190 RQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKR 249
Query: 192 EA---------PAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILS 242
E +KSG+KK + +K + ++ +M+F+E EA ++++L
Sbjct: 250 EVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK 309
Query: 243 EKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKA 302
EK+G+IQD K++ KG+ ++ QL+EK+KLLA +EDAA K + ++L +EM EK
Sbjct: 310 EKSGVIQDALKKSS-KGELTTLI-HQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE 367
Query: 303 KAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQL 362
++ ++K ++ E+E Q ++ SY+E QQ+Q K + ++EQ+E ++
Sbjct: 368 RSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE----TQQMQMKFQQVREQME----AEI 419
Query: 363 ARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
A L+QEN ILRDA++ T+Q+ESKQ+AEL KLRQ+ +++ EL EK+ ++Q+E Q+K
Sbjct: 420 AHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNA 479
Query: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDE------------VSRELCHTQSSHASLRA 470
E A + Q+ + + E + ++KR E V++E QS H+ L
Sbjct: 480 EQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKEN-EVQSLHSKLTD 538
Query: 471 DAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEAL 530
Q+ +Q++ +L ++S + V + L Q+Q+ +N L +I+ +
Sbjct: 539 TLVSKQQLEQRLMQL---MESEQKRVNKE----ESLQMQVQDILEQNEALKAQIQQFHSQ 591
Query: 531 LEAGQARD--AQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLR 588
+ A + A+++ AE D+Q +K+ E ++ E++ + +E + N L
Sbjct: 592 IAAQTSASVLAEELHKVIAEKDKQ---IKQTEDSLAS-ERDRLTSKEEELKDIQNMNFLL 647
Query: 589 EKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQN 648
+ + ++ALA + A +L + Q+ + ++ L+E Q + + E +L QN
Sbjct: 648 KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707
Query: 649 YTEWLQDLKEKGPTLLKHPPAP------AEPSSDLASKLREAEETQST----LQAECDQY 698
L+ +K TL+ P + + KL+ EE T + + ++
Sbjct: 708 KA--LKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEEL 765
Query: 699 RSILAETEGMLRDLQ-------------KSVEEEEQVWRAKVG---AAEEELQKSRVTVK 742
+I E + +++Q VEE ++V K G + EE L+ + V
Sbjct: 766 NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVA 825
Query: 743 HLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQS 802
+ E+ V+ LK E+++ ++E +++ E + ++ S +V L+ LL +
Sbjct: 826 NKEKTVQDLKQEIKA---LKEEIGNVQLEKAQQLSITS--------KVQELQNLLKGKEE 874
Query: 803 QLDAAKSEAQKQSDELALVRQQLSEM-------KSHVEDGDIAGAPASSPEAPPAEQDPV 855
Q++ K+ +++ +LA + L ++ K+HV++ +S + E + V
Sbjct: 875 QMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIV 934
Query: 856 --QLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSET--- 910
+ + +L+ EA+L++ ++ T ++ Q + ++E+L+ ++S
Sbjct: 935 LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPH 994
Query: 911 ------------------EEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLA-RE 951
E LK+ +E ++K +DL E L +T++ L +
Sbjct: 995 EELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKV 1054
Query: 952 KDTVKKLQEQLEKAE 966
T K+ Q+Q+E E
Sbjct: 1055 NKTSKERQQQVEAVE 1069
Score = 100 bits (250), Expect = 5e-21
Identities = 173/853 (20%), Positives = 348/853 (40%), Gaps = 169/853 (19%)
Query: 236 RLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNK 295
RL+ L+EK G +Q + LK QL+E E+ + E+
Sbjct: 457 RLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAER--------------RWEEVQS 502
Query: 296 EMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLE 355
+ A+ A + ++ + VA+E E+ ++ +++ + + QQL+ ++ L E +
Sbjct: 503 YIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLT----DTLVSKQQLEQRLMQLMESEQ 558
Query: 356 NGPNT------QLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKS 409
N Q+ + ++N L+ + Q SQ+ ++ +A + L +EL KV + EK
Sbjct: 559 KRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV--LAEELHKV---IAEKD 613
Query: 410 EAVRQDEQ---------------------------------QRKALEAKAAAFEKQVLQL 436
+ ++Q E Q A E AAA E + +Q
Sbjct: 614 KQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQ 673
Query: 437 QASHRES-----EEALQKRLDEVSRELCHTQSSHASLRADAEKAQ-------------EQ 478
++ EE LQ + E + +L+++ +K Q +
Sbjct: 674 SVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQM 733
Query: 479 QQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARD 538
++ + E KL++ E + + +++ +L R ENS LT+ ++ ++A + Q
Sbjct: 734 EKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK-QNDQVSF 792
Query: 539 AQDVQASQAEADQQQTRLKELES-------QVSGLEKEAIELREAVEQQKVKNNDLREKN 591
A V+ + ++ ++K +E +V+ EK +L++ ++ K + +++ +
Sbjct: 793 ASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE- 851
Query: 592 WKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTE 651
KA + T++ ++L +L + KEE + TM+A+L E N +
Sbjct: 852 -KAQQLSITSKV---QELQNLLKGKEE--------QMNTMKAVL----EEKEKDLANTGK 895
Query: 652 WLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQA---ECDQYRSILAETEGM 708
WLQDL+E+ +L H A+ + AS + EE + L+ E + ++L E E
Sbjct: 896 WLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESD 955
Query: 709 LRD---LQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLK----------GEL 755
L L + V++E +++++++ +++ + + EE+++ + EL
Sbjct: 956 LSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNEL 1015
Query: 756 ESSDQVREHTSHLEAEL-EKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQ 814
+S EH +L EK+ A A + + E Q Q++A + EA++
Sbjct: 1016 DSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEV 1075
Query: 815 SDELALVRQQLSEMKSHVEDGD------------IAGAPASSP----EAPPAEQDPVQLK 858
+L + S++ G+ +AG S E E D +
Sbjct: 1076 LKKLF----PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTL 1131
Query: 859 TQLEW---------TEAILE------DEQTQRQKLTAE-----FEEAQTSACRLQEELEK 898
QLE TE IL+ +++ + K+ + ++ Q+S ++ELE+
Sbjct: 1132 LQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELER 1191
Query: 899 LRTAGPLESSETEEASQLKERLEKEKKLTS-------DLGRAATRLQELLKTTQEQLARE 951
LR+ + E L+ LEK + S +L T LQ+ L + + R+
Sbjct: 1192 LRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQ 1251
Query: 952 KDTVKKLQEQLEK 964
+ + L+ QL +
Sbjct: 1252 NEELNLLKAQLNE 1264
Score = 41.2 bits (95), Expect = 0.005
Identities = 30/124 (24%), Positives = 60/124 (48%), Gaps = 5/124 (4%)
Query: 233 EAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRE 292
E + L ++L+E + D++ +A ++ + + +LK QL E L TEQ + L +
Sbjct: 1226 EVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHK 1285
Query: 293 LNK--EMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTL 350
+ E+ K AAG+ V + + ++ + M S + V ++QQL ++ +
Sbjct: 1286 AQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQL---LQAV 1342
Query: 351 QEQL 354
+QL
Sbjct: 1343 NQQL 1346
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 239 bits (609), Expect = 1e-62
Identities = 260/1075 (24%), Positives = 478/1075 (44%), Gaps = 182/1075 (16%)
Query: 25 IFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKI- 83
IFL MKET Y+E LA Q++E K K +KKK EK K KK+E NG +
Sbjct: 21 IFLFFWLFMKETLYDEVLAKQKREQ-KLIPTKTDKKKAEK------KKNKKKEIQNGNLH 73
Query: 84 -PDHDPAPNVTVLLREPVRAPAVAVAPTPV------------------QPPIIV------ 118
D + P L + + VAP P+ Q P++
Sbjct: 74 ESDSESVPR-DFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKE 132
Query: 119 -------------APVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTS 165
PV P P E AS K +KK K + + V ++ V +
Sbjct: 133 SDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQ---DKKVETLMVPSK 189
Query: 166 KAAIL----ETAPKEGRNTDVAQS------------------------------PEAPKQ 191
+ L ET + G A S P K+
Sbjct: 190 RQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKR 249
Query: 192 EA---------PAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILS 242
E +KSG+KK + +K + ++ +M+F+E EA ++++L
Sbjct: 250 EVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK 309
Query: 243 EKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKA 302
EK+G+IQD K++ KG+ ++ QL+EK+KLLA +EDAA K + ++L +EM EK
Sbjct: 310 EKSGVIQDALKKSS-KGELTTLI-HQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE 367
Query: 303 KAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQL 362
++ ++K ++ E+E Q ++ SY+E QQ+Q K + ++EQ+E ++
Sbjct: 368 RSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE----TQQMQMKFQQVREQME----AEI 419
Query: 363 ARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
A L+QEN ILRDA++ T+Q+ESKQ+AEL KLRQ+ +++ EL EK+ ++Q+E Q+K
Sbjct: 420 AHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNA 479
Query: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDE------------VSRELCHTQSSHASLRA 470
E A + Q+ + + E + ++KR E V++E QS H+ L
Sbjct: 480 EQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE-NEVQSLHSKLTD 538
Query: 471 DAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEAL 530
Q+ +Q++ +L ++S + V + L Q+Q+ +N L +I+ +
Sbjct: 539 TLVSKQQLEQRLMQL---MESEQKRVNKE----ESLQMQVQDILEQNEALKAQIQQFHSQ 591
Query: 531 LEAGQARD--AQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLR 588
+ A + A+++ AE D+Q +K+ E ++ E++ + +E + N L
Sbjct: 592 IAAQTSASVLAEELHKVIAEKDKQ---IKQTEDSLAS-ERDRLTSKEEELKDIQNMNFLL 647
Query: 589 EKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQN 648
+ + ++ALA + A +L + Q+ + ++ L+E Q + + E +L QN
Sbjct: 648 KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707
Query: 649 YTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSI--LAETE 706
+ L+ +K TL+ +P+ D+ E+ + +Q + ++ +++ L ET
Sbjct: 708 --KALKSEVQKLQTLVSE-----QPNKDV------VEQMEKCIQEKDEKLKTVEELLET- 753
Query: 707 GMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVK---HLEEIVEKLKGELESSD-QVR 762
G+++ K EEE R + + +E+Q + +VE+LK + D +++
Sbjct: 754 GLIQVATK--EEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIK 811
Query: 763 EHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELAL-- 820
LEAEL K + +V L+ LL + Q++ K+ +++ +LA
Sbjct: 812 SVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG 871
Query: 821 -----VRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPV--QLKTQLEWTEAILEDEQT 873
++++ +K+HV++ +S + E + V + + +L+ EA+L++ ++
Sbjct: 872 KWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERES 931
Query: 874 QRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSE---------------------TEE 912
T ++ Q + ++E+L+ ++S E
Sbjct: 932 DLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNE 991
Query: 913 ASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLA-REKDTVKKLQEQLEKAE 966
LK+ +E ++K +DL E L +T++ L + T K+ Q+Q+E E
Sbjct: 992 LDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVE 1046
Score = 234 bits (598), Expect = 2e-61
Identities = 199/715 (27%), Positives = 349/715 (48%), Gaps = 75/715 (10%)
Query: 234 AQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLE-----------EKEKLLATEQED 282
A+ L ++++EK I+ T + D + + +L+ E +KL A E
Sbjct: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQ 661
Query: 283 AAVAKS-------------KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
AA A K+R L +++ E + + Q A + E+ +Q +
Sbjct: 662 AAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLV 721
Query: 330 QASYREHVKE-----VQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVE 384
+ V E +Q+ K++T++E LE G Q+A ++E + +R + T +V+
Sbjct: 722 SEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGL-IQVATKEEELNAIRTENSSLTKEVQ 780
Query: 385 ---SKQNAEL--AKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQV-LQLQA 438
+KQN ++ A L +EL KV + EK ++ E+ +A K A EK V L + +
Sbjct: 781 DLKAKQNDQVSFASLVEELKKV---IHEKDGKIKSVEELLEAELLKVANKEKTVQLSITS 837
Query: 439 SHRESEEALQKR----------LDEVSRELCHT-------QSSHASLRADAEKAQEQQQQ 481
+E + L+ + L+E ++L +T Q + SL+A ++ + +
Sbjct: 838 KVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLK 897
Query: 482 MAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSI--EALLEAGQARDA 539
A S+ + E ++ K EL L L+E ++ S T+ ++ + E L Q
Sbjct: 898 EASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQL 957
Query: 540 QDVQASQAEADQQQTRL----KELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAM 595
+ QA + L E E ++SGL E L++AVE Q+ KNNDLREKNW+AM
Sbjct: 958 KQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAM 1017
Query: 596 EALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQD 655
EALA+ E+ ++K++ + +E ++Q+ +E + E L L P++SV + +Y EWL
Sbjct: 1018 EALASTEKMLQDKVN---KTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHG 1074
Query: 656 LKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKS 715
++K + +E L KL+EA+E + LQ EC++Y+S+LAETEG+L+ LQ+S
Sbjct: 1075 FEKKAKECMAGTSG-SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRS 1133
Query: 716 VEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKH 775
VE+EE W+ KV + + +++ + + E+ +E+L+ E + + +R HLE ELEK
Sbjct: 1134 VEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEK- 1192
Query: 776 MAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHV--- 832
A E Y EV L+ L E+ ++L ++E QK + +L +Q L ++S +
Sbjct: 1193 ---AEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKA 1249
Query: 833 -EDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQ 886
D + SPE +E++ + + T+ + + Q Q+LT E E Q
Sbjct: 1250 AGDTTVIENSDVSPETESSEKETMSVSLNQTVTQ-LQQLLQAVNQQLTKEKEHYQ 1303
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 234 bits (597), Expect = 3e-61
Identities = 254/1071 (23%), Positives = 472/1071 (44%), Gaps = 180/1071 (16%)
Query: 25 IFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKI- 83
IFL MKET Y+E LA Q++E K K +KKK EK K KK+E NG +
Sbjct: 21 IFLFFWLFMKETLYDEVLAKQKREQ-KLIPTKTDKKKAEK------KKNKKKEIQNGNLH 73
Query: 84 -PDHDPAPNVTVLLREPVRAPAVAVAPTPV------------------QPPIIV------ 118
D + P L + + VAP P+ Q P++
Sbjct: 74 ESDSESVPR-DFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKE 132
Query: 119 -------------APVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTS 165
PV P P E AS K +KK K + + V ++ V +
Sbjct: 133 SDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQ---DKKVETLMVPSK 189
Query: 166 KAAIL----ETAPKEGRNTDVAQS------------------------------PEAPKQ 191
+ L ET + G A S P K+
Sbjct: 190 RQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKR 249
Query: 192 EA---------PAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILS 242
E +KSG+KK + +K + ++ +M+F+E EA ++++L
Sbjct: 250 EVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK 309
Query: 243 EKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKA 302
EK+G+IQD K++ KG+ ++ QL+EK+KLLA +EDAA K + ++L +EM EK
Sbjct: 310 EKSGVIQDALKKSS-KGELTTLI-HQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE 367
Query: 303 KAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQL 362
++ ++K ++ E+E Q ++ SY+E QQ+Q K + ++EQ+E ++
Sbjct: 368 RSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE----TQQMQMKFQQVREQME----AEI 419
Query: 363 ARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
A L+QEN ILRDA++ T+Q+ESKQ+AEL KLRQ+ +++ EL EK+ ++Q+E Q+K
Sbjct: 420 AHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNA 479
Query: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDE------------VSRELCHTQSSHASLRA 470
E A + Q+ + + E + ++KR E V++E QS H+ L
Sbjct: 480 EQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE-NEVQSLHSKLTD 538
Query: 471 DAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEAL 530
Q+ +Q++ +L ++S + V + L Q+Q+ +N L +I+ +
Sbjct: 539 TLVSKQQLEQRLMQL---MESEQKRVNKE----ESLQMQVQDILEQNEALKAQIQQFHSQ 591
Query: 531 LEAGQARD--AQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLR 588
+ A + A+++ AE D+Q +K+ E ++ E++ + +E + N L
Sbjct: 592 IAAQTSASVLAEELHKVIAEKDKQ---IKQTEDSLAS-ERDRLTSKEEELKDIQNMNFLL 647
Query: 589 EKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQN 648
+ + ++ALA + A +L + Q+ + ++ L+E Q + + E +L QN
Sbjct: 648 KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707
Query: 649 YTEWLQDLKEKGPTLLKHPP------APAEPSSDLASKLREAEETQST----LQAECDQY 698
+ L+ +K TL+ P + + KL+ EE T + + ++
Sbjct: 708 --KALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEEL 765
Query: 699 RSILAETEGMLRDLQ-------------KSVEEEEQVWRAKVG---AAEEELQKSRVTVK 742
+I E + +++Q VEE ++V K G + EE L+ + V
Sbjct: 766 NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVA 825
Query: 743 HLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQS 802
+ E+ V+ LK E+++ ++E +++ E + ++ S +V L+ LL +
Sbjct: 826 NKEKTVQDLKQEIKA---LKEEIGNVQLEKAQQLSITS--------KVQELQNLLKGKEE 874
Query: 803 QLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLE 862
Q++ K+ +++ +LA + L +++ E A E +Q E
Sbjct: 875 QMNTMKAVLEEKEKDLANTGKWLQDLQEENE-----SLKAHVQEVAQHNLKEASSASQFE 929
Query: 863 WTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERL-- 920
E +L++++ + ++L A +E ++ + L+ ++ L S+ E+ Q +
Sbjct: 930 ELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQAS 989
Query: 921 -----EKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAE 966
E+ K+ S+ + + L L + ++ + ++ + Q+Q+E E
Sbjct: 990 SFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVE 1040
Score = 189 bits (479), Expect = 1e-47
Identities = 180/717 (25%), Positives = 331/717 (46%), Gaps = 85/717 (11%)
Query: 234 AQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLE-----------EKEKLLATEQED 282
A+ L ++++EK I+ T + D + + +L+ E +KL A E
Sbjct: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQ 661
Query: 283 AAVAKS-------------KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
AA A K+R L +++ E + + Q A + E+ +Q +
Sbjct: 662 AAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLV 721
Query: 330 QASYREHVKE-----VQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVE 384
+ V E +Q+ K++T++E LE G Q+A ++E + +R + T +V+
Sbjct: 722 SEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGL-IQVATKEEELNAIRTENSSLTKEVQ 780
Query: 385 ---SKQNAEL--AKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQAS 439
+KQN ++ A L +EL KV + EK ++ E+ +A K A EK V
Sbjct: 781 DLKAKQNDQVSFASLVEELKKV---IHEKDGKIKSVEELLEAELLKVANKEKTV------ 831
Query: 440 HRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSK 499
+ L++ + + E+ + Q A + K QE Q + ++ + +A + K
Sbjct: 832 -----QDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEK 886
Query: 500 CEELSGLHGQLQEARAENSQLTERIRSIEA--LLEAGQARDAQDVQASQAEADQQQTRL- 556
++L+ LQ+ + EN L ++ + L EA A ++++ E + + RL
Sbjct: 887 EKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLE 946
Query: 557 ---KELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACK------- 606
KE ES +S + ++++ + K + L+++N++ + E+ K
Sbjct: 947 AMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREK 1006
Query: 607 ------EKLHSLTQAKE-------ESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWL 653
+L SL A E E ++Q+ +E + E L L P++SV + +Y EWL
Sbjct: 1007 EISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWL 1066
Query: 654 QDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQ 713
++K + +E L KL+EA+E + LQ EC++Y+S+LAETEG+L+ LQ
Sbjct: 1067 HGFEKKAKECMAGTSG-SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ 1125
Query: 714 KSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELE 773
+SVE+EE W+ KV + + +++ + + E+ +E+L+ E + + +R HLE ELE
Sbjct: 1126 RSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELE 1185
Query: 774 KHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHV- 832
K A E Y EV L+ L E+ ++L ++E QK + +L +Q L ++S +
Sbjct: 1186 K----AEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIV 1241
Query: 833 ---EDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQ 886
D + SPE +E++ + + T+ + + Q Q+LT E E Q
Sbjct: 1242 KAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQ-LQQLLQAVNQQLTKEKEHYQ 1297
Score = 105 bits (262), Expect = 2e-22
Identities = 173/835 (20%), Positives = 346/835 (41%), Gaps = 165/835 (19%)
Query: 236 RLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNK 295
RL+ L+EK G +Q + LK QL+E E+ + E+
Sbjct: 457 RLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAER--------------RWEEVQS 502
Query: 296 EMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLE 355
+ A+ A + ++ + VA+E E+ ++ +++ + + QQL+ ++ L E +
Sbjct: 503 YIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLT----DTLVSKQQLEQRLMQLMESEQ 558
Query: 356 NGPNT------QLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKS 409
N Q+ + ++N L+ + Q SQ+ ++ +A + L +EL KV + EK
Sbjct: 559 KRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV--LAEELHKV---IAEKD 613
Query: 410 EAVRQDEQ---------------------------------QRKALEAKAAAFEKQVLQL 436
+ ++Q E Q A E AAA E + +Q
Sbjct: 614 KQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQ 673
Query: 437 QASHRES-----EEALQKRLDEVSRELCHTQSSHASLRADAEKAQ-------------EQ 478
++ EE LQ + E + +L+++ +K Q +
Sbjct: 674 SVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQM 733
Query: 479 QQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARD 538
++ + E KL++ E + + +++ +L R ENS LT+ ++ ++A + Q
Sbjct: 734 EKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK-QNDQVSF 792
Query: 539 AQDVQASQAEADQQQTRLKELES-------QVSGLEKEAIELREAVEQQKVKNNDLREKN 591
A V+ + ++ ++K +E +V+ EK +L++ ++ K + +++ +
Sbjct: 793 ASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE- 851
Query: 592 WKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTE 651
KA + T++ ++L +L + KEE + TM+A+L E N +
Sbjct: 852 -KAQQLSITSKV---QELQNLLKGKEE--------QMNTMKAVL----EEKEKDLANTGK 895
Query: 652 WLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRD 711
WLQDL+E+ +L H A+ + AS + EE + +L E E L+
Sbjct: 896 WLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEI-----------VLKEKENELKR 944
Query: 712 LQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAE 771
L+ ++E E +K ++ ++++ +E++ ++ + SS E + +E
Sbjct: 945 LEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ-NYQQASSFPPHEELLKVISE 1003
Query: 772 LEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSH 831
EK ++ E + V R+ E Q Q++A + EA++ +L + S+
Sbjct: 1004 REKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLF----PKVSVPSN 1059
Query: 832 VEDGD------------IAGAPASSP----EAPPAEQDPVQLKTQLEW---------TEA 866
+ G+ +AG S E E D + QLE TE
Sbjct: 1060 LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEG 1119
Query: 867 ILE------DEQTQRQKLTAE-----FEEAQTSACRLQEELEKLRTAGPLESSETEEASQ 915
IL+ +++ + K+ + ++ Q+S ++ELE+LR+ E+ + E +
Sbjct: 1120 ILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRS----ENKDIENLRR 1175
Query: 916 LKERLEKE-KKLTSDLGRAATRLQEL---LKTTQEQLAREKDTVKKLQEQLEKAE 966
+E LE E +K + T ++EL L T +L E++ +K+ L KA+
Sbjct: 1176 EREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQ 1230
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 157 bits (398), Expect = 4e-38
Identities = 170/788 (21%), Positives = 347/788 (44%), Gaps = 50/788 (6%)
Query: 231 EGEAQRLIEILSEKAGIIQDTWHKATQKG--DPVAILKRQLEEKEKLLATEQEDAAVAKS 288
E + RL E L+++A +IQD + Q+ + VA+LK++L + + L+ +
Sbjct: 190 EQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESE 249
Query: 289 KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIR 348
KL++ K++ ++ A + A ++++ +L QE+ +Q + V +L K +
Sbjct: 250 KLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQ----KLKSSVNELTQKNQ 305
Query: 349 TLQEQL--ENGPNTQLARLQQENSILRDALNQATSQVE---SKQNAELAKLRQELSKVSK 403
TL E L + T+L E S+ + + Q + + + L+ L ++
Sbjct: 306 TLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHV 365
Query: 404 ELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEE---ALQKRLDEVSRELCH 460
EL EK EA ++ +++ +E K + + QLQ E E+ LQ ++++ +L
Sbjct: 366 ELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLE 425
Query: 461 TQ----SSHASLRAD----AEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQE 512
T+ +H L+ +EK +++QQ+A+L KL E +++ K + L QL +
Sbjct: 426 TERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDK 485
Query: 513 ARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKEL----ESQVSGLEK 568
+ ++ + +S A L Q D + V + DQ+ L+ L + +S LEK
Sbjct: 486 TKQQHQEQQALQQSTTAKLREAQ-NDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEK 544
Query: 569 EAIELR---EAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCL 625
E +L +A E + N L+EKN E + + K + S QA+E Q+
Sbjct: 545 EREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQE 604
Query: 626 IEAQTMEA---LLALLPELSVL------AQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSD 676
+A A +L+L ++ L +++ ++ +K K LL A +D
Sbjct: 605 QKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRAD 664
Query: 677 LASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQK---SVEEEEQVWRAKVGAAEEE 733
L + L A+ Q E ++ + L + L+D Q+ +E + ++ K + E++
Sbjct: 665 LQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724
Query: 734 LQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGL 793
++ +K LE ++K E + Q + L +LE S + + + V+
Sbjct: 725 TEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSST 784
Query: 794 RQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKS-----HVEDGDIAGAPASSPEAP 848
R L + L++ K + KQ +E +++Q + H E + + +
Sbjct: 785 RLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKV 844
Query: 849 PAEQDPV--QLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLE 906
E++ + +L T + + + + + + E ++ + + L++ ++L+ ++
Sbjct: 845 KMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQ 904
Query: 907 SSET-EEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKA 965
T +E +LK+ LEKEK+ + L +QE L Q L + + ++LQ + +
Sbjct: 905 MENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINEL 964
Query: 966 EDGSSSKE 973
+ S K+
Sbjct: 965 KQSSEQKK 972
Score = 111 bits (278), Expect = 3e-24
Identities = 167/774 (21%), Positives = 339/774 (43%), Gaps = 88/774 (11%)
Query: 249 QDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGE 308
Q HK Q+ L Q++E++ L Q+ ++ + ELN ++ K K + +
Sbjct: 587 QSESHKQAQEN-----LHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLD 641
Query: 309 AKVKKQ---LVAREQEITAVQARMQA---SYREHVKEVQQLQGKIRTLQEQLENGPNTQL 362
++K + L++ E TA +A +Q + + +++ QQ KI T +Q+ +
Sbjct: 642 IQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQ 701
Query: 363 ARLQQENSILRD------ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDE 416
Q S L++ +L Q T ++E ++ KL + +V + + ++Q
Sbjct: 702 EHCSQLESHLKEYKEKYLSLEQKTEELEG----QIKKLEADSLEVKASKEQALQDLQQQR 757
Query: 417 QQRKALEAKAAAFEKQV---LQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAE 473
Q LE +A KQ+ ++ +S R + + L+ + ++L + L+ D E
Sbjct: 758 QLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFE 817
Query: 474 K-AQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLE 532
+QE + Q EL++++Q++ E++ E L +L + + S++++ +++ ++ E
Sbjct: 818 TLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFE 877
Query: 533 AGQARDAQ---DVQASQAEADQQ-----QTRLKELESQVSGLEKEAIELREAVEQQKVKN 584
+ D++ + E Q + LKE + LEKE +EA Q K++
Sbjct: 878 KENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE----KEASHQLKLEL 933
Query: 585 NDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLP--ELS 642
N ++E+ +A L E+ ++ ++ + K+ SE++ IEA E +A+L EL
Sbjct: 934 NSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELE 993
Query: 643 VLAQQNYTEWLQDL---KEKGPTLLKHPPAPAEPSSDLASK--------------LREAE 685
QQ T+ Q+L KEK L + E L S L+ E
Sbjct: 994 NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVE 1053
Query: 686 ETQSTLQAECDQYRSILAETEGMLRDL--------QKSVEEEEQVW-RAKVGAAEEELQK 736
E S Q + R+ + ++++L Q S ++E+Q+ R K A +++QK
Sbjct: 1054 EKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCK---ALQDIQK 1110
Query: 737 SRVTVKHLEEIVEKLK-GELESSDQVRE-HTSHLEAELEKHMAAASAECQNYAKEVAGLR 794
+ ++K E + EK K E+E +E + L EL+ H + E N L
Sbjct: 1111 EK-SLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLI 1169
Query: 795 QLLLESQSQLDAAKSEAQKQSDELALVRQQLSE-----MKSHVEDGDIAGAPASSPEAPP 849
Q LE Q + D+ K+ +++ +++ Q+ + K +E + E
Sbjct: 1170 QQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGM 1229
Query: 850 AEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLR-TAGPLESS 908
+ + + K ++ T A+ E+ T ++ E++ +Q L+++ + LR LE++
Sbjct: 1230 KKHEENEAKLTMQIT-ALNENLGTVKK----EWQSSQRRVSELEKQTDDLRGEIAVLEAT 1284
Query: 909 ETEEASQLKERLEKEKKLTSDLGRAATRLQELLK------TTQEQLAREKDTVK 956
+ + LE+ K ++ + T++ EL + ++L RE +++
Sbjct: 1285 VQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
Score = 97.8 bits (242), Expect = 4e-20
Identities = 160/745 (21%), Positives = 303/745 (40%), Gaps = 142/745 (19%)
Query: 338 KEVQQLQGKIRT-------LQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAE 390
+EVQ LQ ++ L+++LE Q + + + + +AE
Sbjct: 90 QEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLV-------------TDSSAE 136
Query: 391 LAKLRQELS---------KVSKELVEKSEA----------VRQDEQQ--RKALEAKAAAF 429
L L Q+L K K+L E+ A + DE++ R+A E K
Sbjct: 137 LQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRL 196
Query: 430 ------EKQVLQ------LQASHRESEEALQKRLDEVSREL----CHTQSSHASLRADAE 473
E V+Q LQ E L+K L +V + + L+ + +
Sbjct: 197 TEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECK 256
Query: 474 KAQEQ----QQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIE- 528
K Q Q + +++L S+L EV +EL L + E +N LTE + E
Sbjct: 257 KLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQ 316
Query: 529 --ALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNND 586
LE ++ + QA Q+ ++L+S++S E + + ++
Sbjct: 317 DYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK 376
Query: 587 LREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLP------- 639
L+E+ + + T Q K + L Q +EE E+ ++++ + LL
Sbjct: 377 LKEE----LSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGE 432
Query: 640 ---------ELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKL----REAEE 686
+LS + + + DL+ K L + S++L +L ++ +E
Sbjct: 433 AHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQE 492
Query: 687 TQSTLQAECDQYRSILAETEGMLRD--------------LQKS------VEEEEQVWRAK 726
Q+ Q+ + R + E +LR LQKS +E+E + AK
Sbjct: 493 QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAK 552
Query: 727 VGAAEEEL-------QKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAA 779
+ A E E +K+ + + ++ EKLK + ES Q +E+ E + H+ AA
Sbjct: 553 IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAA 612
Query: 780 SAECQNYAKEVAGLRQLLLESQ---SQLD-AAKSEAQKQSDELALVRQQLSEMKSHVEDG 835
+ V L L ES+ SQLD K++ + A Q +++++H++
Sbjct: 613 QDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTA 672
Query: 836 DIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEE 895
A +Q+ ++ TQL+ A L+D+Q +L + +E + L+++
Sbjct: 673 QNA--------LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724
Query: 896 LEKLR------TAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRL-------QELLK 942
E+L A LE ++E Q + L+++++L +DL AT L +E++
Sbjct: 725 TEELEGQIKKLEADSLEVKASKE--QALQDLQQQRQLNTDLELRATELSKQLEMEKEIVS 782
Query: 943 TTQEQLAREKDTVKKLQEQLEKAED 967
+T+ L ++ + ++ ++++L K E+
Sbjct: 783 STRLDLQKKSEALESIKQKLTKQEE 807
Score = 92.8 bits (229), Expect = 1e-18
Identities = 129/562 (22%), Positives = 243/562 (43%), Gaps = 78/562 (13%)
Query: 444 EEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAE----VRSK 499
E L + D+V+ Q ASL+ + ++E ++++ E + LQ EA+ V
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKEL-EKYQGLQQQEAKPDGLVTDS 133
Query: 500 CEELSGLHGQLQEARAEN--------------SQLTERIRSIEALL-EAGQARDA--QDV 542
EL L QL+EA+ EN +QL I I++ E R+A Q V
Sbjct: 134 SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV 193
Query: 543 QASQAEADQQQTRLKELESQV---SGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALA 599
E +++ T +++L++++ G+E A+ +E V+ Q + +N E+ ++ +
Sbjct: 194 TRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEK--- 250
Query: 600 TAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEK 659
+ CK KL S + E + QL A+ + + + EL L + +L +K
Sbjct: 251 -LKDECK-KLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSS-----VNELTQK 303
Query: 660 GPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEE 719
TL ++ + + L K E ++ +QA Q +DL +
Sbjct: 304 NQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQ------------KDL------D 345
Query: 720 EQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAA 779
Q ++++ A+E L + V + E +KLK EL + +H +L++
Sbjct: 346 CQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEK 405
Query: 780 SAECQNYAKEVAGLRQLLLESQSQLDAA----KSEAQKQSDELALVRQQLSEMK---SHV 832
E+ L LLE++ QL A K + Q S++L QQ+++++ S +
Sbjct: 406 EQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRL 465
Query: 833 EDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRL 892
E+ + + +L+ QL+ T+ +++Q +Q TA+ EAQ ++
Sbjct: 466 EE-----------QLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQV 514
Query: 893 QEEL----EKLRTAGPLESSETEEASQL-KERLEKEKKLTSDLGRAA--TRLQELLKTTQ 945
++ +K++ L E S L KER + K+ + G A +LQE T Q
Sbjct: 515 LRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ 574
Query: 946 EQLAREKDTVKKLQEQLEKAED 967
EQ+ + + +K E ++A++
Sbjct: 575 EQVTQLTEKLKNQSESHKQAQE 596
Score = 73.2 bits (178), Expect = 1e-12
Identities = 109/590 (18%), Positives = 243/590 (41%), Gaps = 62/590 (10%)
Query: 47 KEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREP----VRA 102
KE+ + ++KK + K+ TK++EEK K D + T + E ++
Sbjct: 778 KEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILK-QDFETLSQETKIQHEELNNRIQT 836
Query: 103 PAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQV 162
+ ++ ++ ++TV + S K + EK+ K + A+
Sbjct: 837 TVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILD------- 889
Query: 163 LTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLVS 222
LE KE ++ Q K++ KK +K+ L + L+
Sbjct: 890 -------LEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQ 942
Query: 223 TVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQ----KGD-PVAIL-KRQLEEK-EKL 275
++ NE E Q+L ++E + Q + K Q +G+ +A+L K +LE K ++
Sbjct: 943 AQNTLKQNEKEEQQLQGNINE---LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQ 999
Query: 276 LATEQEDAAVAKSKLREL--NKEMAAEKAKAAAGEAKVKK-QLVAREQEITAVQARMQAS 332
L ++ A K K+ L N E + E K + ++ +L+A Q++ +V+ ++ +
Sbjct: 1000 LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLA 1059
Query: 333 YREHVKEVQQLQGKIRTLQE------QLENGPNTQLARLQQENSILRDALNQAT------ 380
+ + Q+ + + +QE LE + +LQ+ L+D + +
Sbjct: 1060 QEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKEL 1119
Query: 381 ----------SQVESKQNAELAKLRQELSKVS----KELVEKSEAVRQDEQQRKALEAKA 426
+++ +Q E+ KL +EL KE+ +A + QQ+ L+ KA
Sbjct: 1120 VNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA 1179
Query: 427 AAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSS-HASLRADAEKAQEQQQQMAEL 485
+ + V Q + + + ++ ++K +E+ +E ++ H+ ++ ++ ++ A+L
Sbjct: 1180 DSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKL 1239
Query: 486 HSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQA- 544
++ + + + +E ++ E + L I +EA ++ Q ++
Sbjct: 1240 TMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERC 1299
Query: 545 --SQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNW 592
+ E ++ QT++ EL+ ++ EL + ++K+ + W
Sbjct: 1300 LKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKW 1349
Score = 41.2 bits (95), Expect = 0.005
Identities = 52/267 (19%), Positives = 105/267 (39%), Gaps = 35/267 (13%)
Query: 744 LEEIVEKLKGELES--SDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQ 801
L I+++ G + S SD T ++ ++ C K + +L +
Sbjct: 2 LRRILQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYE 61
Query: 802 SQLDAAKSEAQKQSDELALVRQQLSEMKSHVED--GDIAGAPASSPEAPPAEQDPVQLKT 859
+ DA LAL R ++ ++ V+D + S E + L+
Sbjct: 62 AVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQ 121
Query: 860 QLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQE--ELEKLRTA------GPLESSETE 911
Q + ++ D + Q L + EEAQT +++ +L + + A ++S E
Sbjct: 122 QEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDE 181
Query: 912 EASQLKERLEKEKKLTSDLGRAATRLQEL----------------------LKTTQEQLA 949
E S + +K +LT +L + AT +Q+L ++T + +
Sbjct: 182 ERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMT 241
Query: 950 REKD-TVKKLQEQLEKAEDGSSSKEGT 975
E++ +KL+++ +K + +S E T
Sbjct: 242 LERERESEKLKDECKKLQSQYASSEAT 268
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 143 bits (360), Expect = 9e-34
Identities = 191/821 (23%), Positives = 361/821 (43%), Gaps = 125/821 (15%)
Query: 235 QRLIEILSEKAGII------QDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKS 288
++++ +L EK + QD A ++ D + K QLE K K + ED
Sbjct: 875 EKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDE----- 929
Query: 289 KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIR 348
E+N E+ A+K K +++K+ + E + V+ KE + K++
Sbjct: 930 --EEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVE-----------KEKHATENKVK 976
Query: 349 TLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNA--ELAKLRQELSKVSKEL- 405
L E++ G + +A+L +E L++A QA ++++++ L K + +L + +L
Sbjct: 977 NLTEEMA-GLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLE 1035
Query: 406 --VEKSEAVRQD-EQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQ 462
+E+ + VR D E+ ++ LE ++ ++ L+ ++ +E L+K+ E++ +
Sbjct: 1036 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE 1095
Query: 463 SSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEEL-SGLHGQLQEARAENSQLT 521
A +K +E Q ++ EL +L++ E R+K E+L S L +L+E + +L
Sbjct: 1096 DEQALGSQLQKKLKELQARIEELEEELEA-ERTARAKVEKLRSDLSRELEEI---SERLE 1151
Query: 522 ERIRSIEALLEAGQARDAQ------DVQAS--QAEADQQQTRLK------ELESQVSGLE 567
E + +E + R+A+ D++ + Q EA R K EL Q+ L+
Sbjct: 1152 EAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQ 1211
Query: 568 KEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACK---EKLHSLTQAKEESEKQLC 624
+ +L + + K++ +D+ + ++A A E+ C+ ++++ EE+++ +
Sbjct: 1212 RVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN 1271
Query: 625 LIEAQTMEA------LLALLPELSVLAQQ------NYTEWLQDLKE------KGPTLLKH 666
+ +Q + L L E L Q YT+ L+DLK K L H
Sbjct: 1272 DLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAH 1331
Query: 667 PPAPAEPSSDLASKLREAE-ETQSTLQAECDQYRSILA------ETEGMLRDLQKSVEEE 719
A DL + E E E ++ LQ + S +A ET+ + R + +EE
Sbjct: 1332 ALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRT--EELEEA 1389
Query: 720 EQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAA 779
++ ++ AEE ++ LE+ +L+ E+E L ++E+ AAA
Sbjct: 1390 KKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIED----------LMVDVERSNAAA 1439
Query: 780 SA---ECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVED-- 834
+A + +N+ K +A +Q ESQS+L++++ EA+ S EL ++ E H+E
Sbjct: 1440 AALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFK 1499
Query: 835 ----------GDIAGAPASSPEA--------PPAEQDPVQLKTQLEWTEAILEDEQTQRQ 876
D+ SS + E + ++L++ LE EA LE E+ +
Sbjct: 1500 RENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKIL 1559
Query: 877 KLTAEFE----EAQTSACRLQEELEK-----LRTAGPLESSETEEASQLKERLEKEKKLT 927
+ EF E + EE+E+ LR L++S E E L +KK+
Sbjct: 1560 RAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKME 1619
Query: 928 SDLGRAATRL---QELLKTTQEQLAREKDTVKKLQEQLEKA 965
DL +L + Q+Q+ + +K Q QL+ A
Sbjct: 1620 GDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDA 1660
Score = 128 bits (321), Expect = 3e-29
Identities = 193/894 (21%), Positives = 378/894 (42%), Gaps = 97/894 (10%)
Query: 132 LASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAP-- 189
LA K+K E KV + ++ + I LT + L+ A ++ + A+ +
Sbjct: 961 LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTL 1020
Query: 190 -----KQEAPAKKKSGS---KKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEIL 241
K E GS +KK D + L T S++ E + Q+L E L
Sbjct: 1021 TKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERL 1080
Query: 242 SEKA-------GIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELN 294
+K I+D +Q + L+ ++EE E+ L E+ A + +L+
Sbjct: 1081 KKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLS 1140
Query: 295 KEMA--AEKAKAAAGEAKVKKQL-VAREQEITAVQARMQASYREHVKEVQQLQGK----I 347
+E+ +E+ + A G V+ ++ RE E ++ ++ + +H L+ K +
Sbjct: 1141 RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSV 1200
Query: 348 RTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVE 407
L EQ++N + +L++E S + L+ TS +E ++ K + L K+ + L +
Sbjct: 1201 AELGEQIDNLQRVK-QKLEKEKSEFKLELDDVTSNME-----QIIKAKANLEKMCRTLED 1254
Query: 408 KSEAVRQDEQQRKALEAKAAAFE--KQVLQLQASHRESEEALQKRLDEVSRELCHTQSSH 465
+ +E + KA E + + + Q +LQ + E L ++LDE +
Sbjct: 1255 Q-----MNEHRSKAEETQRSVNDLTSQRAKLQTENGE----LSRQLDEKEALISQLTRGK 1305
Query: 466 ASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIR 525
+ E + Q ++ + + L + R C+ L + + EA+AE ++ +
Sbjct: 1306 LTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAN 1365
Query: 526 SIEALLEAGQARDAQDVQASQAEADQQQT------RLKELESQVSGLEKEAIELREAVEQ 579
S E Q R + A Q + ++ RL+E E V + + L + +
Sbjct: 1366 S-----EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHR 1420
Query: 580 QKVKNNDLR---EKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLA 636
+ + DL E++ A AL ++ + L Q EES+ +L E+ EA +
Sbjct: 1421 LQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSEL---ESSQKEAR-S 1476
Query: 637 LLPELSVL--AQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAE 694
L EL L A + E L+ K + L + E + E E+ + L+AE
Sbjct: 1477 LSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAE 1536
Query: 695 CDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVG-----------AAEEELQKSRVTVKH 743
+ +S L E E L EE ++ RA++ AE++ + + H
Sbjct: 1537 KMELQSALEEAEASLE------HEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNH 1590
Query: 744 LEEIVEKLKGELESSDQVREHTSHLEAELE----------KHMAAASAECQNYAKEVAGL 793
L +V+ L+ L++ + R ++ ++E H +AE Q K+V L
Sbjct: 1591 LR-VVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQ---KQVKSL 1646
Query: 794 RQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQD 853
+ LL ++Q QLD A + +A+V ++ + +++ +E+ A + AEQ+
Sbjct: 1647 QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR-AVVEQTERSRKLAEQE 1705
Query: 854 PVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEA 913
++ +++ + Q++K+ A+ + QT ++E +++ R A +A
Sbjct: 1706 LIETSERVQLLHSQNTSLINQKKKMDADLSQLQT---EVEEAVQECRNAEEKAKKAITDA 1762
Query: 914 SQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQL-AREKDTVKKLQEQLEKAE 966
+ + E L+KE+ ++ L R +++ +K Q +L E+ +K ++QL+K E
Sbjct: 1763 AMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLE 1816
Score = 98.6 bits (244), Expect = 3e-20
Identities = 158/734 (21%), Positives = 312/734 (42%), Gaps = 89/734 (12%)
Query: 273 EKLLATEQEDAAVAKSKLRELNK---EMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
EK+ T ++ +SK E + ++ +++AK ++ +QL +E I+ +
Sbjct: 1246 EKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT--- 1302
Query: 330 QASYREHVKEVQQLQGKIRTLQEQLE--NGPNTQLARLQQENSILRDALNQATS------ 381
R + QQL+ R L+E+++ N L + + +LR+ + T
Sbjct: 1303 ----RGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQ 1358
Query: 382 QVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHR 441
+V SK N+E+A+ R +K + ++++E + E+ +K L + E+ V + A
Sbjct: 1359 RVLSKANSEVAQWR---TKYETDAIQRTEEL---EEAKKKLAQRLQEAEEAVEAVNAKCS 1412
Query: 442 ESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQ-------EQQQQMAELHSKLQSSEA 494
E+ + +E+ + + S+A+ A +K + E +Q+ E S+L+SS+
Sbjct: 1413 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1472
Query: 495 EVRSKCEELSGLHGQLQEA-------RAENSQLTERIRSI-EALLEAGQARDAQDVQASQ 546
E RS EL L +E+ + EN L E I + E L +G+ + Q
Sbjct: 1473 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQ 1532
Query: 547 AEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVK---NNDLREKNWKAMEALATAEQ 603
EA++ + + E++ S +E LR +E ++K L EK+ + ME
Sbjct: 1533 LEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD-EEMEQAKRNHL 1591
Query: 604 ACKEKLHSLTQAKEESEKQLCLIEAQT------MEALLALLPELSVLAQQNYTEWLQDLK 657
+ L + A+ S + ++ + ME L+ ++ AQ+ LK
Sbjct: 1592 RVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLK 1651
Query: 658 EKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSV- 716
+ T ++ A + DL + E + LQAE ++ R+++ +TE + ++ +
Sbjct: 1652 D---TQIQLDDA-VRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELI 1707
Query: 717 --EEEEQVWRAKVGAAEEELQKSRVTVKHL----EEIVEKLKGELESSDQVREHTSHLEA 770
E Q+ ++ + + +K + L EE V++ + E + + + +
Sbjct: 1708 ETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAE 1767
Query: 771 ELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSD-ELALVRQQLSEMK 829
EL+K SA + K + Q + + Q +LD A+ A K +L + ++ E++
Sbjct: 1768 ELKKEQDT-SAHLERMKKN---MEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELE 1823
Query: 830 SHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSA 889
+ +E AEQ K E + + + E+ ++ LT + EE + +
Sbjct: 1824 NELE----------------AEQ-----KRNAESVKGMRKSERRIKE-LTYQTEEDRKNL 1861
Query: 890 CRLQEELEKLRTAGPLESSETEEA-SQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQL 948
RLQ+ ++KL+ + EEA Q L K +K+ +L A R +
Sbjct: 1862 LRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLR 1921
Query: 949 AREKDT-VKKLQEQ 961
A+ +D K L E+
Sbjct: 1922 AKSRDIGTKGLNEE 1935
Score = 79.7 bits (195), Expect = 1e-14
Identities = 90/375 (24%), Positives = 174/375 (46%), Gaps = 39/375 (10%)
Query: 264 ILKRQLE------EKEKLLATEQEDAAVAKSK----LRELNKEMAAE-KAKAAAGEAKVK 312
IL+ QLE E E+ LA + E+ AK + L + AE +++ A K K
Sbjct: 1558 ILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKK 1617
Query: 313 KQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQ------LARLQ 366
+ E EI A A+ E K+V+ LQ ++ Q QL++ +A ++
Sbjct: 1618 MEGDLNEMEIQLSHANRMAA--EAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVE 1675
Query: 367 QENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKA 426
+ N++L+ L + + VE + + KL ++ EL+E SE V+ Q +L +
Sbjct: 1676 RRNNLLQAELEELRAVVEQTERSR--KLAEQ------ELIETSERVQLLHSQNTSLINQK 1727
Query: 427 AAFEKQVLQLQASHRESEEALQK-RLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAEL 485
+ + QLQ E EEA+Q+ R E + T + A + + +K Q+ + +
Sbjct: 1728 KKMDADLSQLQT---EVEEAVQECRNAEEKAKKAITDA--AMMAEELKKEQDTSAHLERM 1782
Query: 486 HSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQAS 545
++ + +++ + +E + L+ + + +L R+R +E LEA Q R+A+ V+
Sbjct: 1783 KKNMEQTIKDLQHRLDEAEQI--ALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGM 1840
Query: 546 QAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQAC 605
+ + + R+KEL Q K + L++ V++ ++K + + +A E T
Sbjct: 1841 R----KSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1896
Query: 606 KEKLHSLTQAKEESE 620
++ H L +A+E ++
Sbjct: 1897 RKVQHELDEAEERAD 1911
Score = 63.9 bits (154), Expect = 7e-10
Identities = 60/261 (22%), Positives = 118/261 (45%), Gaps = 15/261 (5%)
Query: 709 LRDLQKSVEEEEQV--WRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTS 766
++ L KS E E+++ + + +E L+KS K LEE + L E ++
Sbjct: 836 IKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQE--------KNDL 887
Query: 767 HLEAELEK-HMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQL 825
L+ + E+ ++A A C K L + E +L+ + + + + + +
Sbjct: 888 QLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDEC 947
Query: 826 SEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEA 885
SE+K ++D ++ A E E L ++ + I+ +++ L ++A
Sbjct: 948 SELKRDIDDLELTLAKVEK-EKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 1006
Query: 886 QTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQ 945
LQ E +K+ T + ++ L+ LE+EKK+ DL RA +L+ LK TQ
Sbjct: 1007 LDD---LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 1063
Query: 946 EQLAREKDTVKKLQEQLEKAE 966
E + ++ ++L E+L+K +
Sbjct: 1064 ESIMDLENDKQQLDERLKKKD 1084
Score = 60.8 bits (146), Expect = 6e-09
Identities = 90/450 (20%), Positives = 178/450 (39%), Gaps = 55/450 (12%)
Query: 543 QASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAE 602
+ A ++ TRLKE + KE E ++ Q+K NDL+ + + LA AE
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEK---NDLQLQVQAEQDNLADAE 902
Query: 603 QAC----KEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKE 658
+ C K K+ + KE +E+ + E + A L + +E +D+ +
Sbjct: 903 ERCDQLIKNKIQLEAKVKEMNER------LEDEEEMNAELTAKKRKLEDECSELKRDIDD 956
Query: 659 KGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEE 718
TL K + + E L E I+A+ L +K+++E
Sbjct: 957 LELTLAK-----------VEKEKHATENKVKNLTEEMAGLDEIIAK----LTKEKKALQE 1001
Query: 719 EEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAA 778
Q + A E+++ LE+ V+ L+G LE +VR + +LE +
Sbjct: 1002 AHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKL 1061
Query: 779 ASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIA 838
+ + L + L + +L+A + + + + ++++L E+++ +E+ +
Sbjct: 1062 TQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELE-E 1120
Query: 839 GAPASSPEAPPAEQDPVQLKTQLEWTEAILED--------------EQTQRQKLTAEFEE 884
A E+ L +LE LE+ + + QK+ + EE
Sbjct: 1121 ELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE 1180
Query: 885 AQTSACRLQEELEKLRTAGPLESSE-TEEASQLKERLEKEKK--------LTSDLG---R 932
A L K E E + ++K++LEKEK +TS++ +
Sbjct: 1181 ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIK 1240
Query: 933 AATRLQELLKTTQEQLAREKDTVKKLQEQL 962
A L+++ +T ++Q+ + ++ Q +
Sbjct: 1241 AKANLEKMCRTLEDQMNEHRSKAEETQRSV 1270
Score = 43.5 bits (101), Expect = 0.001
Identities = 37/194 (19%), Positives = 91/194 (46%), Gaps = 9/194 (4%)
Query: 788 KEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHV--EDGDIAGAPASSP 845
KE+A +++ + L+ +++ ++ +++ + Q+ ++++ V E ++A A
Sbjct: 847 KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCD 906
Query: 846 EAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLR-TAGP 904
+ ++ +QL+ +++ LEDE+ +LTA+ + + L+ +++ L T
Sbjct: 907 QLI---KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAK 963
Query: 905 LESSETEEASQLKERLEKEK---KLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQ 961
+E + +++K E+ ++ + L + LQE + + L E+D V L +
Sbjct: 964 VEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKA 1023
Query: 962 LEKAEDGSSSKEGT 975
K E EG+
Sbjct: 1024 KVKLEQQVDDLEGS 1037
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 139 bits (350), Expect = 1e-32
Identities = 207/1017 (20%), Positives = 428/1017 (42%), Gaps = 94/1017 (9%)
Query: 33 MKETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKE--------EKPNGKIP 84
+K E+ +AN ++E KT + + + K K +E+K T +E + +
Sbjct: 844 LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALA 903
Query: 85 DHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEK 144
D + + + + + A V I A + +++ + KD E
Sbjct: 904 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 963
Query: 145 KVAKVEPAVSSVVNSIQVLTSKAAIL-ETAPKEGRNTDVAQSP----------EAPKQEA 193
+AKVE + N ++ LT + A L ET K + Q E K
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNT 1023
Query: 194 PAKKKSGSKKKGPPDADGPLYLPYK--------------TLVSTVGSMVFNEGEAQRLIE 239
K K+ +++ D +G L K L S + E + Q+L E
Sbjct: 1024 LTKAKTKLEQQ-VDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNE 1082
Query: 240 ILSEK-------AGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRE 292
L +K G I+D A Q + L+ ++EE E+ + E+ A A+ + +
Sbjct: 1083 KLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1142
Query: 293 LNKEM--AAEKAKAAAGEAKVKKQL-VAREQEITAVQARMQASYREHVKEVQQLQGK--- 346
L++E+ +E+ + A G + ++ RE E ++ ++ S +H L+ K
Sbjct: 1143 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHAD 1202
Query: 347 -IRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVE--SKQNAELAK----LRQELS 399
+ L EQ+++ + +L++E S L+ +N S +E SK A K L +LS
Sbjct: 1203 SVAELGEQIDSLQRVK-QKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLS 1261
Query: 400 KVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRE---SEEALQKRLDEVSR 456
++ + E+ + + Q+ L ++ F +Q+ + A + ++A ++++E+ R
Sbjct: 1262 EIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKR 1321
Query: 457 ELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAE 516
+L + ++L + A+ + E + + Q ++AE++ +S + ++ + R +
Sbjct: 1322 QLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQ---RGMSKANSEVAQWRTK 1378
Query: 517 NSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREA 576
T+ I+ E L EA + + AQ +Q ++ + ++ LE L+ E +L
Sbjct: 1379 YE--TDAIQRTEELEEA-KKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMID 1435
Query: 577 VEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLA 636
VE+ L +K + LA +Q +E L +++ES + L + A
Sbjct: 1436 VERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKES-RSLSTELFKVKNAYEE 1494
Query: 637 LLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECD 696
L L L ++N ++L+++ L + + +L ++ + +S LQ +
Sbjct: 1495 SLDHLETLKREN-----KNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLE 1549
Query: 697 QYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEEL-QKSRVTVKHLEEIVEKLKGEL 755
+ + L EG + +Q + + + K+ +EEL Q R ++ +E + L E+
Sbjct: 1550 EAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEI 1609
Query: 756 ESSDQVREHTSHLEA---ELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQ 812
S + +E E+E + A+ + + + + +L ++Q LD A
Sbjct: 1610 RSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQD 1669
Query: 813 KQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQ 872
++LA+V ++ + M++ VE+ A + AEQ+ + +++
Sbjct: 1670 DLKEQLAMVERRANLMQAEVEELR-ASLERTERGRKMAEQELLDASERVQLL-------H 1721
Query: 873 TQRQKLTAEFEEAQTSACRLQEELEKL----RTAGPLESSETEEASQLKERLEKEKKLTS 928
TQ L ++ +T ++Q E+E + R A +A+ + E L+KE+ ++
Sbjct: 1722 TQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSA 1781
Query: 929 DLGRAATRLQELLKTTQ------EQLARE--KDTVKKLQEQLEKAEDGSSSKEGTSV 977
L R +++ +K Q EQLA + K ++KL+ ++ + E S++ +V
Sbjct: 1782 HLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNV 1838
Score = 89.0 bits (219), Expect = 2e-17
Identities = 188/906 (20%), Positives = 360/906 (39%), Gaps = 125/906 (13%)
Query: 39 EEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLRE 98
E+ALA Q ++ K ++E+ ++E E+ + K ++++ + ++ L E
Sbjct: 1101 EQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS----RELEEISERLEE 1156
Query: 99 PVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVN 158
A + + + + + A++ +KK VA++ + S+
Sbjct: 1157 AGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQR 1216
Query: 159 SIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYK 218
Q L KE + + A E +K K+ +K +
Sbjct: 1217 VKQKLE----------KEKSELKMEINDLASNMETVSKAKANFEKM------------CR 1254
Query: 219 TLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLAT 278
TL + + E E QRLI LS + + T+ G+ RQL+EK+ +++
Sbjct: 1255 TLEDQLSEIKTKEEEQQRLINELSAQKARLH------TESGE----FSRQLDEKDAMVSQ 1304
Query: 279 EQEDAAVAKSKLRELNKEMAAE-KAKAAAGEAKVKKQL---VAREQ--EITAVQARMQAS 332
++ EL +++ E KAK+ A + + REQ E +A +Q
Sbjct: 1305 LSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRG 1364
Query: 333 YREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQN--AE 390
+ EV Q + K T Q + L++ L L A VE+ + A
Sbjct: 1365 MSKANSEVAQWRTKYETDAIQ-------RTEELEEAKKKLAQRLQDAEEHVEAVNSKCAS 1417
Query: 391 LAKLRQELSKVSKEL---VEKSEA--VRQDEQQR---KALEAKAAAFEKQVLQLQASHRE 442
L K +Q L ++L VE+S A + D++QR K L +E+ +L+AS +E
Sbjct: 1418 LEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKE 1477
Query: 443 SEEA---LQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSK 499
S L K + L H ++ + ++ + +Q+AE + E +
Sbjct: 1478 SRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQL 1537
Query: 500 CEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQ-QQTRLKE 558
E S L L+EA A +I I+ L ++ + + E DQ ++ L+
Sbjct: 1538 DHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRV 1597
Query: 559 LESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEE 618
+ES S L+ E +A+ +K DL E + A A +A + ++ K+
Sbjct: 1598 VESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDT 1657
Query: 619 SEKQLCLIEA----QTMEALLALLPELSVLAQQNYTEWLQDLK--EKGPTLLKHPPAPAE 672
QL L +A ++ LA++ + L Q E L+ E+G + + +
Sbjct: 1658 ---QLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAE------Q 1708
Query: 673 PSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDL-QKSVEEEEQVWRAKVGAA- 730
D + +++ ++L + + +++ +G + D+ Q++ EE+ +A AA
Sbjct: 1709 ELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAM 1768
Query: 731 -EEELQKSRVTVKHLEEI-------VEKLKGELESSDQV-----REHTSHLEAELEKHMA 777
EEL+K + T HLE + V+ L+ L+ ++Q+ ++ LEA + + +
Sbjct: 1769 MAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELES 1828
Query: 778 AASAECQNYAKEVAGLRQ---LLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVED 834
+E ++ + V GLR+ + E Q + + + D + ++ ++ K E+
Sbjct: 1829 EVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEE 1888
Query: 835 GDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQE 894
+ EQ V L + +KL E EEA+ A +
Sbjct: 1889 AE--------------EQSNVNL---------------AKFRKLQHELEEAKERADIAES 1919
Query: 895 ELEKLR 900
++ KLR
Sbjct: 1920 QVNKLR 1925
Score = 60.5 bits (145), Expect = 8e-09
Identities = 68/273 (24%), Positives = 121/273 (44%), Gaps = 23/273 (8%)
Query: 709 LRDLQKSVEEEEQVWRAK--VGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTS 766
++ L KS E E+++ K +EEL K+ K LEE + L E ++
Sbjct: 840 IKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQE--------KNDL 891
Query: 767 HLEAELEKH-MAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQL 825
L+ + E +A A C K L + E + + + + + + + +
Sbjct: 892 QLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 951
Query: 826 SEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQ----LEWTEAILEDEQTQRQKLTAE 881
SE+K ++D ++ A + A ++ V+ T+ L+ T A L E+ Q
Sbjct: 952 SELKKDIDDLELTLAKVEKEKH--ATENKVKNLTEEMAGLDETIAKLTKEKKALQ----- 1004
Query: 882 FEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELL 941
E Q + LQ E +K+ T ++ ++ L+ LE+EKKL DL RA +L+ L
Sbjct: 1005 -EAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDL 1063
Query: 942 KTTQEQLAREKDTVKKLQEQLEKAEDGSSSKEG 974
K QE ++ ++L E+L+K E S+ +G
Sbjct: 1064 KLAQESTMDTENDKQQLNEKLKKKEFEMSNLQG 1096
Score = 50.1 bits (118), Expect = 1e-05
Identities = 62/242 (25%), Positives = 114/242 (47%), Gaps = 36/242 (14%)
Query: 271 EKEKLLATEQEDAAVAKSKLR----ELNKEM---------AAEKAKAAAGEAKVKKQLVA 317
E+ +LL T+ K KL ++ EM A EKAK A +A + + +
Sbjct: 1715 ERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELK 1774
Query: 318 REQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALN 377
+EQ+ +A RM+ + + VK+ LQ ++ ++ G Q+ +L+ +
Sbjct: 1775 KEQDTSAHLERMKKNMEQTVKD---LQLRLDEAEQLALKGGKKQIQKLEAR-------VR 1824
Query: 378 QATSQVESKQ--NAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQ 435
+ S+VES+Q N E K ++ + KEL Q E+ RK + +K +
Sbjct: 1825 ELESEVESEQKHNVEAVKGLRKHERRVKEL------TYQTEEDRKNILRLQDLVDKLQTK 1878
Query: 436 LQASHRESEEALQKRLDEVS--RELCHTQSSHASLRADAEKAQEQQQQM--AELHSKLQS 491
++A R++EEA ++ ++ R+L H + A RAD ++Q + ++ E+H+K+ S
Sbjct: 1879 VKAYKRQAEEAEEQSNVNLAKFRKLQH-ELEEAKERADIAESQVNKLRVKSREVHTKVIS 1937
Query: 492 SE 493
E
Sbjct: 1938 EE 1939
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 139 bits (349), Expect = 2e-32
Identities = 205/1013 (20%), Positives = 426/1013 (42%), Gaps = 99/1013 (9%)
Query: 33 MKETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKE--------EKPNGKIP 84
+K E+ +AN ++E KT + + + K K +E+K T +E + +
Sbjct: 844 LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLA 903
Query: 85 DHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEK 144
D + + + + + A V I A + +++ + KD E
Sbjct: 904 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 963
Query: 145 KVAKVEPAVSSVVNSIQVLTSKAAIL-ETAPKEGRNTDVAQSP--------EAPKQEAPA 195
+AKVE + N ++ LT + A L ET K + Q +A + +
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1023
Query: 196 KKKSGSK-KKGPPDADGPLYLPYK--------------TLVSTVGSMVFNEGEAQRLIEI 240
K+ K ++ D +G L K L S + E + Q+L E
Sbjct: 1024 LTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEK 1083
Query: 241 LSEK----AGI---IQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLREL 293
L +K +G+ I+D Q + L+ ++EE E+ + E+ A A+ + +L
Sbjct: 1084 LKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1143
Query: 294 NKEM--AAEKAKAAAGEAKVKKQL-VAREQEITAVQARMQASYREHVKEVQQLQGK---- 346
++E+ +E+ + A G + ++ RE E ++ ++ + +H L+ K
Sbjct: 1144 SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADS 1203
Query: 347 IRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVE--SKQNAELAK----LRQELSK 400
+ L EQ++N + +L++E S ++ ++ S +E SK L K L +LS+
Sbjct: 1204 VAELGEQIDNLQRVK-QKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSE 1262
Query: 401 VSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQ---LQASHRESEEALQKRLDEVSRE 457
+ + E+ + QR L+ ++ + +Q+ + L + ++A ++++E+ R+
Sbjct: 1263 IKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQ 1322
Query: 458 L-----CHTQSSHA--SLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQL 510
L + +HA S R D + +EQ ++ E ++LQ + ++ S
Sbjct: 1323 LEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANS------------ 1370
Query: 511 QEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEA 570
+ A+ T+ I+ E L EA + + AQ +Q ++ + + LE L+ E
Sbjct: 1371 EVAQWRTKYETDAIQRTEELEEA-KKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEV 1429
Query: 571 IELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQT 630
+L VE+ L +K + LA +Q C E+ H+ +A ++ + L +
Sbjct: 1430 EDLMIDVERTNAACAALDKKQRNFDKILAEWKQKC-EETHAELEASQKESRSLSTELFKI 1488
Query: 631 MEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQST 690
A L +L L ++N ++L+++ L + + +L ++ E+ +S
Sbjct: 1489 KNAYEESLDQLETLKREN-----KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSE 1543
Query: 691 LQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEEL-QKSRVTVKHLEEIVE 749
LQA ++ + L EG + +Q + + + K+ +EE+ Q R ++ +E +
Sbjct: 1544 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQS 1603
Query: 750 KLKGELESSDQVREHTSHLEA---ELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDA 806
L E+ S + +E E+E + A+ + + +L ++Q LD
Sbjct: 1604 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDD 1663
Query: 807 AKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEA 866
A + ++LA+V ++ + +++ +E+ A + AEQ+ + +++
Sbjct: 1664 ALRSQEDLKEQLAMVERRANLLQAEIEELR-ATLEQTERSRKIAEQELLDASERVQLL-- 1720
Query: 867 ILEDEQTQRQKLTAEFEEAQTSACRLQEELEKL----RTAGPLESSETEEASQLKERLEK 922
TQ L ++ +T ++Q E+E + R A +A+ + E L+K
Sbjct: 1721 -----HTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKK 1775
Query: 923 EKKLTSDLGRAATRLQELLKTTQEQL-AREKDTVKKLQEQLEKAEDGSSSKEG 974
E+ ++ L R L++ +K Q +L E+ +K ++Q++K E EG
Sbjct: 1776 EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEG 1828
Score = 104 bits (260), Expect = 4e-22
Identities = 187/900 (20%), Positives = 376/900 (41%), Gaps = 141/900 (15%)
Query: 127 MPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKE--GRNTDVAQ 184
+ QE DK++ ++K+ K E +S + + I+ + L+ KE R ++ +
Sbjct: 1065 LAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEE 1124
Query: 185 SPEAPK-QEAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSE 243
EA + A A+K+ + + L + + E E Q++ L E
Sbjct: 1125 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1184
Query: 244 KAGIIQDTWHKAT------QKGDPVAILKRQLE---------EKEKL--------LATEQ 280
H+AT + D VA L Q++ EKEK LA+
Sbjct: 1185 AT-----LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNM 1239
Query: 281 EDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEV 340
E + AK L ++ + + + ++ E + ++ + ++TA +AR+Q E+ +++
Sbjct: 1240 ETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLI----NDLTAQRARLQTESGEYSRQL 1295
Query: 341 QQLQGKIRTLQEQLENGPNT------QLARLQQENSILRDALNQATS-----------QV 383
+ TL QL G +L R +E + AL A Q
Sbjct: 1296 DEKD----TLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQY 1351
Query: 384 ESKQNAELAKLRQELSKVSKELVE-----KSEAVRQDEQ---QRKALEAKAAAFEKQVLQ 435
E +Q A+ A+L++ +SK + E+ + +++A+++ E+ +K L + E+ V
Sbjct: 1352 EEEQEAK-AELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEA 1410
Query: 436 LQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQ-------EQQQQMAELHSK 488
+ A E+ Q+ +EV + + ++A+ A +K + E +Q+ E H++
Sbjct: 1411 VNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAE 1470
Query: 489 LQSSEAEVRSKCEELSGLHG-------QLQEARAENSQLTERIRSI-EALLEAGQA---- 536
L++S+ E RS EL + QL+ + EN L + I + E + E G+
Sbjct: 1471 LEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL 1530
Query: 537 -----RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNND----L 587
+ Q+ QA ++ + L+ E ++ ++ E +++ V+++ + ++ +
Sbjct: 1531 EKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQM 1590
Query: 588 REKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQ 647
+ + + +E++ + A + + K++ E L +E Q A ++ A +
Sbjct: 1591 KRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHA-----NRMAAEALR 1645
Query: 648 NYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEG 707
NY LK+ T L H DL +L E + LQAE ++ R+ L +TE
Sbjct: 1646 NYRNTQAILKD---TQL-HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER 1701
Query: 708 MLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSH 767
+K E+E +V + T K LE + +++GE+E + + +
Sbjct: 1702 S----RKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMED---IIQEARN 1754
Query: 768 LEAELEKHMAAASAECQNYAKEV----------AGLRQLLLESQSQLDAAKSEAQKQSDE 817
E + +K + A+ + KE L Q + + Q +LD A+ A K
Sbjct: 1755 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG-- 1812
Query: 818 LALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQK 877
++Q+ ++++ V + + G S + K +E + + + E+ ++
Sbjct: 1813 ----KKQIQKLEARVRE--LEGEVES------------EQKRNVEAVKGLRKHERKVKE- 1853
Query: 878 LTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEA-SQLKERLEKEKKLTSDLGRAATR 936
LT + EE + + RLQ+ ++KL+ + EEA Q L K +++ +L A R
Sbjct: 1854 LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEER 1913
Score = 85.1 bits (209), Expect = 3e-16
Identities = 152/779 (19%), Positives = 329/779 (42%), Gaps = 140/779 (17%)
Query: 130 EKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPK--EGRNTDVAQSPE 187
E++ + + K+K EK+ ++++ + + ++++ ++ LE + E + +++ E
Sbjct: 1209 EQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEE 1268
Query: 188 APK--------QEAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTV--GSMVFNEGEAQRL 237
+ Q A + +SG + + D TLVS + G F + + + L
Sbjct: 1269 EQQRLINDLTAQRARLQTESGEYSRQLDEKD--------TLVSQLSRGKQAFTQ-QIEEL 1319
Query: 238 IEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEM 297
L E+ H +L+ Q EE+++ A Q + A S++ + +
Sbjct: 1320 KRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKY 1379
Query: 298 AAEKAKAAAGEAKVKKQLVAR----EQEITAVQA----------RMQASYREHVKEVQQL 343
+ + + KK+L R E+ + AV A R+Q + + +V++
Sbjct: 1380 ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERT 1439
Query: 344 QGKIRTLQEQLEN-------------GPNTQLARLQQENSIL-------RDALNQATSQV 383
L ++ N + +L Q+E+ L ++A ++ Q+
Sbjct: 1440 NAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQL 1499
Query: 384 ESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRES 443
E+ + E L+QE+S +++++ E + + + E+ +K +E + + +LQA+ E+
Sbjct: 1500 ETLKR-ENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKS-------ELQAALEEA 1551
Query: 444 EEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSS-----EAEVRS 498
E +L+ ++ R + + + E+ QM H ++ S +AE+RS
Sbjct: 1552 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRS 1611
Query: 499 KCE----------ELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAE 548
+ + +L+ + QL A ++ R+ +A+L+ Q D SQ +
Sbjct: 1612 RNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLH-LDDALRSQED 1670
Query: 549 ADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEK 608
+Q L +E + + L+ E ELR +EQ + R + E L +E+ +
Sbjct: 1671 LKEQ---LAMVERRANLLQAEIEELRATLEQTE------RSRKIAEQELLDASERV--QL 1719
Query: 609 LH----SLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLL 664
LH SL K++ E + I+ + ++ + ++ +EK +
Sbjct: 1720 LHTQNTSLINTKKKLETDISQIQGE----------------MEDIIQEARNAEEKAKKAI 1763
Query: 665 KHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWR 724
+D A E ++ Q T A ++ + L +T ++DLQ ++E EQ+
Sbjct: 1764 ----------TDAAMMAEELKKEQDT-SAHLERMKKNLEQT---VKDLQHRLDEAEQL-- 1807
Query: 725 AKVGAAEEELQKSRVTVKHLE-EIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAEC 783
+ ++++QK V+ LE E+ + K +E+ +R+H E+ + + +
Sbjct: 1808 -ALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKH--------ERKVKELTYQT 1858
Query: 784 QNYAKEVAGLRQLLLESQSQLDAAK---SEAQKQSD-ELALVRQQLSEMKSHVEDGDIA 838
+ K + L+ L+ + Q+++ + K EA++QS+ L+ R+ E++ E DIA
Sbjct: 1859 EEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIA 1917
Score = 58.2 bits (139), Expect = 4e-08
Identities = 76/309 (24%), Positives = 144/309 (46%), Gaps = 41/309 (13%)
Query: 696 DQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLE--EIVEKLKG 753
++ ++ T+ M R VE ++ V R + + ++ + VKH ++ K+K
Sbjct: 783 EKLAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKP 842
Query: 754 ELESSDQVREHTSHLEAELEK---HMAAASAECQNYAKEVAGLRQ----LLLESQSQLDA 806
L+S++ +E ++++ E EK +A A+ + +++ L Q L L+ Q++ D+
Sbjct: 843 LLKSAETEKE-MANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADS 901
Query: 807 AKSEAQKQSDELALVRQQLS----EMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQ-- 860
++A+++ D+L + QL E+ ED + A ++ + E + +LK
Sbjct: 902 L-ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK-LEDECSELKKDID 959
Query: 861 -LEWTEAILEDEQTQRQ------------------KLTAE---FEEA-QTSACRLQEELE 897
LE T A +E E+ + KLT E +EA Q + LQ E +
Sbjct: 960 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1019
Query: 898 KLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKK 957
K+ T + ++ L+ LE+EKK+ DL RA +L+ LK QE ++ ++
Sbjct: 1020 KVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQ 1079
Query: 958 LQEQLEKAE 966
L E+L+K E
Sbjct: 1080 LDEKLKKKE 1088
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 138 bits (347), Expect = 3e-32
Identities = 188/821 (22%), Positives = 357/821 (43%), Gaps = 125/821 (15%)
Query: 235 QRLIEILSEKAGII------QDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKS 288
++++ +L EK + QD + A ++ D + K QLE K K + ED
Sbjct: 877 EKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDE----- 931
Query: 289 KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIR 348
E+N E+ A+K K +++KK + E + V+ KE + K++
Sbjct: 932 --EEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVE-----------KEKHATENKVK 978
Query: 349 TLQEQLENGPNTQLARLQQENSILRDALNQATS--QVESKQNAELAKLRQELSKVSKEL- 405
L E++ G + +A+L +E L++A QA QVE + L+K + +L + +L
Sbjct: 979 NLTEEMA-GLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLE 1037
Query: 406 --VEKSEAVRQD-EQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQ 462
+E+ + VR D E+ ++ LE ++ ++ L+ + EE L+K+ +++++ +
Sbjct: 1038 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIE 1097
Query: 463 SSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEEL-SGLHGQLQEARAENSQLT 521
+K +E Q ++ EL +L++ E R+K E+L S L +L+E + +L
Sbjct: 1098 DEQVLALQLQKKLKENQARIEELEEELEA-ERTARAKVEKLRSDLSRELEEI---SERLE 1153
Query: 522 ERIRSIEALLEAGQARDAQ------DVQAS--QAEADQQQTRLK------ELESQVSGLE 567
E + +E + R+A+ D++ + Q EA R K EL Q+ L+
Sbjct: 1154 EAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQ 1213
Query: 568 KEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKE----------KLHSLTQAKE 617
+ +L + + K++ +D+ + ++A A E+ + KL ++
Sbjct: 1214 RVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLN 1273
Query: 618 ESEKQLCLIEAQTMEALLALLPELSVLAQQ-----NYTEWLQDLKE------KGPTLLKH 666
+ Q ++ + E L + ++++Q +YT+ ++DLK K L H
Sbjct: 1274 DFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAH 1333
Query: 667 PPAPAEPSSDLASKLREAE-ETQSTLQAECDQYRSILA------ETEGMLRDLQKSVEEE 719
A DL + E E E ++ LQ + S +A ET+ + R + +EE
Sbjct: 1334 ALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRT--EELEEA 1391
Query: 720 EQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAA 779
++ ++ AEE ++ LE+ +L+ E+E L ++E+ AAA
Sbjct: 1392 KKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIED----------LMVDVERSNAAA 1441
Query: 780 SA---ECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVE--- 833
+A + +N+ K +A +Q ESQS+L++++ EA+ S EL ++ E H+E
Sbjct: 1442 AALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFK 1501
Query: 834 ------DGDIAGAPASSPEA-----------PPAEQDPVQLKTQLEWTEAILEDEQTQRQ 876
+I+ E E + ++L++ LE EA LE E+ +
Sbjct: 1502 RENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKIL 1561
Query: 877 KLTAEFE----EAQTSACRLQEELEKL-----RTAGPLESSETEEASQLKERLEKEKKLT 927
+ EF E + EE+E+ R L++S E E L +KK+
Sbjct: 1562 RAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKME 1621
Query: 928 SDLGRAATRL---QELLKTTQEQLAREKDTVKKLQEQLEKA 965
DL +L + Q+Q+ + +K Q QL+ A
Sbjct: 1622 GDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDA 1662
Score = 125 bits (314), Expect = 2e-28
Identities = 185/904 (20%), Positives = 385/904 (42%), Gaps = 101/904 (11%)
Query: 132 LASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPK---------EGRNTDV 182
LA K+K E KV + ++ + I LT + L+ A + E + +
Sbjct: 963 LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSL 1022
Query: 183 AQSPEAPKQEAP--------AKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEA 234
++S +Q+ KK ++ +G L L ++++ + E +
Sbjct: 1023 SKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKL 1082
Query: 235 QRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELN 294
++ ++++ I+D A Q + + ++EE E+ L E+ A + +L+
Sbjct: 1083 KKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLS 1142
Query: 295 KEMA--AEKAKAAAGEAKVKKQL-VAREQEITAVQARMQASYREHVKEVQQLQGK----I 347
+E+ +E+ + A G V+ ++ RE E ++ ++ + +H L+ K +
Sbjct: 1143 RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSV 1202
Query: 348 RTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVE 407
L EQ++N + +L++E S + L+ TS +E ++ K + L KVS+ L +
Sbjct: 1203 AELGEQIDNLQRVK-QKLEKEKSEFKLELDDVTSNME-----QIIKAKANLEKVSRTLED 1256
Query: 408 KSEA--VRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSH 465
++ V+ +E QR + F Q +LQ + E L ++L+E +
Sbjct: 1257 QANEYRVKLEEAQRSLND-----FTTQRAKLQTENGE----LARQLEEKEALISQLTRGK 1307
Query: 466 ASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIR 525
S E + Q ++ + + L + R C+ L + + EA+AE ++ +
Sbjct: 1308 LSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAN 1367
Query: 526 SIEALLEAGQARDAQDVQASQAEADQQQT------RLKELESQVSGLEKEAIELREAVEQ 579
S E Q R + A Q + ++ RL++ E V + + L + +
Sbjct: 1368 S-----EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHR 1422
Query: 580 QKVKNNDLR---EKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLA 636
+ + DL E++ A AL ++ + L Q EES+ +L E+ EA +
Sbjct: 1423 LQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSEL---ESSQKEAR-S 1478
Query: 637 LLPELSVL--AQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAE 694
L EL L A + E L+ K + L + E + + E E+ + L+ E
Sbjct: 1479 LSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVE 1538
Query: 695 CDQYRSILAETEGMLRDLQKSVEEEEQVWRA-------------KVGAAEEELQKSRVTV 741
+ +S L E E L EE ++ RA K+ +EE+++++
Sbjct: 1539 KLELQSALEEAEASLE------HEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAK--- 1589
Query: 742 KHLEEIVEKLKGELESSDQVREHTSHLEAELE----------KHMAAASAECQNYAKEVA 791
++ + +V+ L+ L++ + R ++ ++E H +AE Q K+V
Sbjct: 1590 RNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQ---KQVK 1646
Query: 792 GLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAE 851
L+ LL ++Q QLD A + +A+V ++ + +++ +E+ A + AE
Sbjct: 1647 SLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR-AVVEQTERSRKLAE 1705
Query: 852 QDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETE 911
Q+ ++ +++ + Q++K+ ++ + Q+ ++E +++ R A
Sbjct: 1706 QELIETSERVQLLHSQNTSLINQKKKMESDLTQLQS---EVEEAVQECRNAEEKAKKAIT 1762
Query: 912 EASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQL-AREKDTVKKLQEQLEKAEDGSS 970
+A+ + E L+KE+ ++ L R +++ +K Q +L E+ +K ++QL+K E
Sbjct: 1763 DAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVR 1822
Query: 971 SKEG 974
EG
Sbjct: 1823 ELEG 1826
Score = 95.9 bits (237), Expect = 2e-19
Identities = 129/601 (21%), Positives = 265/601 (44%), Gaps = 102/601 (16%)
Query: 268 QLEEKEKLLATEQEDAAVA--------------KSKLRELNKEMAAEKAKAAAGEAKVKK 313
+LEE +K LA +DA A K +L+ +++ + ++ A A + K
Sbjct: 1387 ELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDK 1446
Query: 314 QLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNT------QLARLQQ 367
+++ + A + Y E E++ Q + R+L +L N L ++
Sbjct: 1447 ----KQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKR 1502
Query: 368 ENSILRDALNQATSQVESKQNAELAKLRQELSKVSKEL-VEKSEAVRQDEQQRKALEAKA 426
EN L++ ++ T Q+ E K EL KV K+L VEK E E+ +LE +
Sbjct: 1503 ENKNLQEEISDLTEQL-----GEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHE- 1556
Query: 427 AAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELH 486
E ++L+ Q + + ++++L E E+ + +H ++ + Q +
Sbjct: 1557 ---EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNH-------QRVVDSLQTSLDAE 1606
Query: 487 SKLQSSEAEVRSKCE-ELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQAS 545
++ ++ V+ K E +L+ + QL A ++ ++++S+++LL+ Q + V+A+
Sbjct: 1607 TRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAN 1666
Query: 546 QAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQAC 605
D + + +E + + L+ E ELR VEQ + R + E + T+E+
Sbjct: 1667 ----DDLKENIAIVERRNNLLQAELEELRAVVEQTE------RSRKLAEQELIETSERV- 1715
Query: 606 KEKLHS----LTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGP 661
+ LHS L K++ E L ++++ EA+ + ++ +EK
Sbjct: 1716 -QLLHSQNTSLINQKKKMESDLTQLQSEVEEAV----------------QECRNAEEKAK 1758
Query: 662 TLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQ 721
+ +D A E ++ Q T A ++ + + +T ++DLQ ++E EQ
Sbjct: 1759 KAI----------TDAAMMAEELKKEQDT-SAHLERMKKNMEQT---IKDLQHRLDEAEQ 1804
Query: 722 VWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASA 781
+ + +++LQK LE V +L+GELE+ + + + E+ + +
Sbjct: 1805 I---ALKGGKKQLQK-------LEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTY 1854
Query: 782 ECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDE----LALVRQQLSEMKSHVEDGDI 837
+ + K + L+ L+ + Q ++ A K +A++ ++ L+ R+ E+ E DI
Sbjct: 1855 QTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADI 1914
Query: 838 A 838
A
Sbjct: 1915 A 1915
Score = 70.5 bits (171), Expect = 7e-12
Identities = 127/516 (24%), Positives = 199/516 (38%), Gaps = 115/516 (22%)
Query: 550 DQQQTRLKELESQVSGL--EKEAIELREAVEQQ---------------------KVKNND 586
++ + R KELE ++ L EK ++L+ EQ KVK +
Sbjct: 866 EKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMN 925
Query: 587 LREKNWKAMEALATA-----EQACKEKLH-----SLTQAKEESEKQL-------CLIEAQ 629
R ++ + M A TA E C E LT AK E EK E
Sbjct: 926 ERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 985
Query: 630 TMEALLALLPELSVLAQQNYTEWLQDL---KEKGPTLLKHPPAPAEPSSDLASKLREAEE 686
++ ++A L + Q+ + + L DL ++K +L K + DL L + ++
Sbjct: 986 GLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKK 1045
Query: 687 TQSTLQAECDQYRSILAETEGMLRDL--------------------QKSVEEEEQVW--- 723
+ L+ + L T+ + DL Q S E+EQV
Sbjct: 1046 VRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQ 1105
Query: 724 --------RAKVGAAEEELQKSRVT-----------VKHLEEIVEKLKGELESSDQVREH 764
+A++ EEEL+ R + LEEI E+L+ ++ E
Sbjct: 1106 LQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEM 1165
Query: 765 TSHLEAELEK-----------HMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQK 813
EAE +K H A A+A + +A VA L + Q+D + QK
Sbjct: 1166 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGE-------QIDNLQRVKQK 1218
Query: 814 QSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPV-QLKTQLEWTEAILEDEQ 872
E + + +L ++ S++E I A A+ + +D + + +LE + L D
Sbjct: 1219 LEKEKSEFKLELDDVTSNME--QIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFT 1276
Query: 873 TQRQKLTAEFEEAQTSACRLQEELEKL---RTAGPLESSETEEASQLKERLEKEKKLTSD 929
TQR KL E E R EE E L T G L S T++ LK +LE+E K +
Sbjct: 1277 TQRAKLQTENGE----LARQLEEKEALISQLTRGKL--SYTQQMEDLKRQLEEEGKAKNA 1330
Query: 930 LGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKA 965
L A + +EQ E + +LQ L KA
Sbjct: 1331 LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKA 1366
Score = 63.9 bits (154), Expect = 7e-10
Identities = 60/261 (22%), Positives = 118/261 (45%), Gaps = 15/261 (5%)
Query: 709 LRDLQKSVEEEEQV--WRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTS 766
++ L KS E E+++ + + G +E L+KS K LEE + L E ++
Sbjct: 838 IKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQE--------KNDL 889
Query: 767 HLEAELEK-HMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQL 825
L+ + E+ ++ A C K L + E +L+ + + + + + +
Sbjct: 890 QLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDEC 949
Query: 826 SEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEA 885
SE+K ++D ++ A E E L ++ + I+ +++ L ++A
Sbjct: 950 SELKKDIDDLELTLAKVEK-EKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 1008
Query: 886 QTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQ 945
LQ E +K+ + + ++ L+ LE+EKK+ DL RA +L+ LK TQ
Sbjct: 1009 LDD---LQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 1065
Query: 946 EQLAREKDTVKKLQEQLEKAE 966
E + ++ +L+E+L+K E
Sbjct: 1066 ESIMDLENDKLQLEEKLKKKE 1086
Score = 40.8 bits (94), Expect = 0.006
Identities = 34/192 (17%), Positives = 89/192 (46%), Gaps = 5/192 (2%)
Query: 788 KEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEA 847
KE+A +++ + L+ +++ ++ +++ + Q+ ++++ V+ + +
Sbjct: 849 KEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQ-AEQDNLNDAEERC 907
Query: 848 PPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLR-TAGPLE 906
++ +QL+ +++ LEDE+ +LTA+ + + L+++++ L T +E
Sbjct: 908 DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVE 967
Query: 907 SSETEEASQLKERLEKEK---KLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLE 963
+ +++K E+ ++ + L + LQE + + L E+D V L +
Sbjct: 968 KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKV 1027
Query: 964 KAEDGSSSKEGT 975
K E EG+
Sbjct: 1028 KLEQQVDDLEGS 1039
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 135 bits (339), Expect = 2e-31
Identities = 187/818 (22%), Positives = 347/818 (42%), Gaps = 134/818 (16%)
Query: 224 VGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDA 283
+ S + E + + L E L E+ + + K D + LKR +++ E L +++
Sbjct: 913 IKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEK 972
Query: 284 AVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQL 343
++K++ L++EM A E+ I+ + ++ H + + L
Sbjct: 973 HATENKVKNLSEEM------------------TALEENISKLTKEKKSLQEAHQQTLDDL 1014
Query: 344 QGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSK 403
Q ++E NG A+L+Q+ L +L Q E K A+L + ++ K+
Sbjct: 1015 Q-----VEEDKVNGLIKINAKLEQQTDDLEGSLEQ-----EKKLRADLERAKR---KLEG 1061
Query: 404 ELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQS 463
+L E++ E ++ +E K E ++ QLQA ++D+ Q
Sbjct: 1062 DLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQA-----------KIDDEQVHSLQFQK 1110
Query: 464 SHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTER 523
L+A E+ +E+ + L +K++ +++ + EE+S +L+EA S E
Sbjct: 1111 KIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEIS---ERLEEASGATSAQIEM 1167
Query: 524 IRSIEALLEAGQARDAQDV----QASQAEADQQQT-RLKELESQVSGLEKEAIELREAVE 578
+ EA + RD ++ +A+ A ++Q + EL Q+ L++ +L +
Sbjct: 1168 NKKREAEFQK-MRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKS 1226
Query: 579 QQKVKNNDLREKNWKAMEALATAEQACK--EKLHSLTQAKEESEKQL--------CLIEA 628
+ K++ +D+ ++ + E+ C+ E S +AK+E + QL ++
Sbjct: 1227 ELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQT 1286
Query: 629 QTMEALLALLPELSVLAQ-----QNYTEWLQDLKE--KGPTLLKHPPAPAEPSSD----- 676
Q E + + S+++Q Q T+ L++LK + T K+ A A SS
Sbjct: 1287 QNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDL 1346
Query: 677 LASKLREAEETQSTLQAECDQYRSILA------ETEGMLRDLQKSVEEEEQVWRAKVGAA 730
L + E +E ++ LQ + S +A ET+ + R + +EE ++ ++ A
Sbjct: 1347 LREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQR--TEELEEAKKKLAQRLQEA 1404
Query: 731 EEELQKSRVTVKHLEEIVEKLKGELES--SDQVREHTSHLEAELEKHMAAASAECQNYAK 788
EE + + LE+ ++L+GE+E D R HT+ A + +N+ K
Sbjct: 1405 EENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA---------CATLDKKQRNFDK 1455
Query: 789 EVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVE--------------- 833
+A +Q L ESQ++L+AA+ E++ S EL +R E+ +E
Sbjct: 1456 VLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISD 1515
Query: 834 -DGDIAGAPASSPEAPP----AEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTS 888
IA + EA EQ+ L+ LE E LE E+++ ++ E + ++
Sbjct: 1516 LTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSE 1575
Query: 889 ACR----LQEELEKL-----RTAGPLESSETEEASQLKERLEKEKKLTSDL--------- 930
R EE+E+L R A L+S E + L +KK+ DL
Sbjct: 1576 LDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGH 1635
Query: 931 -GRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAED 967
R Q+ L+T Q QL KD+ L + L ED
Sbjct: 1636 SNRQMAETQKHLRTVQGQL---KDSQLHLDDALRSNED 1670
Score = 120 bits (301), Expect = 6e-27
Identities = 171/871 (19%), Positives = 367/871 (42%), Gaps = 66/871 (7%)
Query: 130 EKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKA--AILETAPKEGRNTDVAQSPE 187
E++ + ++ K K+ ++ A ++ +QV K I A E + D+ S E
Sbjct: 984 EEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLE 1043
Query: 188 APKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGI 247
QE KK ++ +G L + ++++ E + ++ LS+
Sbjct: 1044 ---QE---KKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAK 1097
Query: 248 IQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMA--AEKAKAA 305
I D + Q + L+ ++EE E+ + E A + + +L +E+ +E+ + A
Sbjct: 1098 IDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEA 1157
Query: 306 AGEAKVKKQL-VAREQEITAVQARMQASYREHVKEVQQLQGK----IRTLQEQLENGPNT 360
+G + ++ RE E ++ ++ + +H L+ K + L EQ++N
Sbjct: 1158 SGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRV 1217
Query: 361 QLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEK-SEAVRQDEQQR 419
+ +L++E S L+ ++ S +E+ L+K + + + + + ++ SE +DEQQ
Sbjct: 1218 K-QKLEKEKSELKMEIDDMASNIEA-----LSKSKSNIERTCRTVEDQFSEIKAKDEQQT 1271
Query: 420 KALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQ 479
+ + Q +LQ + E L R++E + S +L E+ + Q
Sbjct: 1272 QLIHD----LNMQKARLQTQNGE----LSHRVEEKESLISQLTKSKQALTQQLEELKRQM 1323
Query: 480 QQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDA 539
++ + + + + R C+ L + + QEA+AE + + S E Q R
Sbjct: 1324 EEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANS-----EVAQWRTK 1378
Query: 540 QDVQASQAEADQQQT------RLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWK 593
+ A Q + ++ RL+E E + L + ++ + + DL +
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLER 1438
Query: 594 AMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVL--AQQNYTE 651
+ A AT ++ + L + K++ ++ +EA E+ +L EL + A + +
Sbjct: 1439 SHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESR-SLSTELFKMRNAYEEVVD 1497
Query: 652 WLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRD 711
L+ L+ + L + E ++ L+EAE+T+ ++ E + L E EG L
Sbjct: 1498 QLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEH 1557
Query: 712 LQKSV--------EEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVRE 763
+ + + + ++ R + EE Q R + + E + L E+ S +
Sbjct: 1558 EESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALR 1617
Query: 764 HTSHLEAELEK------HMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDE 817
+E +L + H AE Q + + V G L +SQ LD A + ++
Sbjct: 1618 LKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQ---LKDSQLHLDDALRSNEDLKEQ 1674
Query: 818 LALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQK 877
LA+V ++ + +E+ +A + +EQ+ + +++ + ++K
Sbjct: 1675 LAIVERRNGLLLEELEEMKVA-LEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKK 1733
Query: 878 LTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRL 937
L A+ + Q ++ +++ R A +A+ + E L+KE+ ++ L R L
Sbjct: 1734 LEADIAQCQ---AEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1790
Query: 938 QELLKTTQEQL-AREKDTVKKLQEQLEKAED 967
++ +K Q +L E+ +K ++Q++K E+
Sbjct: 1791 EQTVKDLQHRLDEAEQLALKGGKKQIQKLEN 1821
Score = 107 bits (267), Expect = 5e-23
Identities = 158/732 (21%), Positives = 316/732 (43%), Gaps = 72/732 (9%)
Query: 271 EKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQ 330
E EK +AT +ED K +L A++ A ++++++V+ QE +Q ++Q
Sbjct: 848 EAEKEMATMKEDFERTKEEL-----------ARSEARRKELEEKMVSLLQEKNDLQLQVQ 896
Query: 331 ASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVE--SKQN 388
+ + ++ +G I++ + LE RL++E + + + + + + S
Sbjct: 897 SETENLMDAEERCEGLIKS-KILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLK 955
Query: 389 AELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQ 448
++ L L+KV KE V+ ++ ALE + K+ LQ +H+++ + LQ
Sbjct: 956 RDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQ 1015
Query: 449 KRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM-AELHSKLQSSEAEVRSKCEELSGLH 507
D+V+ L + D E + EQ++++ A+L + E +++ E + L
Sbjct: 1016 VEEDKVNG-LIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLE 1074
Query: 508 GQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGLE 567
Q Q+ E+++ E L QA+ + Q + Q Q ++KEL++++ LE
Sbjct: 1075 NDKQ-------QIEEKLKKKEFELSQLQAK----IDDEQVHSLQFQKKIKELQARIEELE 1123
Query: 568 KEAIE----LREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQL 623
+E IE LR +E+Q+ +DL + + E L A A ++ + + E +K
Sbjct: 1124 EE-IEAEHTLRAKIEKQR---SDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMR 1179
Query: 624 CLIEAQTM--EALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKL 681
+E T+ EA A L + + E + +L+ L K D+AS +
Sbjct: 1180 RDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNI 1239
Query: 682 REAEETQSTLQAEC----DQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKS 737
+++S ++ C DQ+ I A+ E + L + ++ + + G +++
Sbjct: 1240 EALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQ-LIHDLNMQKARLQTQNGELSHRVEEK 1298
Query: 738 RVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLL 797
+ L + + L +LE + E + + + + ++ +C ++ ++
Sbjct: 1299 ESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAK 1358
Query: 798 LESQSQLDAAKSE-----------AQKQSDELALVRQQLSEMKSHVEDG-DIAGAPASSP 845
E Q L A SE A ++++EL +++L++ E+ + A + +S
Sbjct: 1359 AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASL 1418
Query: 846 EAPPAE-QDPVQ-LKTQLEWTE---AILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLR 900
E Q V+ L LE + A L+ +Q K+ AE+++ +L E +L
Sbjct: 1419 EKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQ------KLDESQAELE 1472
Query: 901 TAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLA------REKDT 954
A S + E +++ E+ L R LQE + EQ+A +E +
Sbjct: 1473 AAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEK 1532
Query: 955 VKKLQEQLEKAE 966
KKL EQ EK++
Sbjct: 1533 TKKLVEQ-EKSD 1543
Score = 105 bits (261), Expect = 3e-22
Identities = 162/806 (20%), Positives = 331/806 (41%), Gaps = 90/806 (11%)
Query: 233 EAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRE 292
E + + E L E +G ++ ++R LEE AT Q +A A LR+
Sbjct: 1146 ELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEE-----ATLQHEATAAT--LRK 1198
Query: 293 LNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQE 352
+ AE + +VK++L + E+ M ++ K ++ RT+++
Sbjct: 1199 KQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVED 1258
Query: 353 QLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAV 412
Q A+ +Q+ ++ D LN +++++ QN EL+ +E + +L + +A+
Sbjct: 1259 QFSEIK----AKDEQQTQLIHD-LNMQKARLQT-QNGELSHRVEEKESLISQLTKSKQAL 1312
Query: 413 RQD-EQQRKALEAKAAAFEKQVLQLQASH------RESEEALQKRLDEVSRELCHTQSSH 465
Q E+ ++ +E + A LQ+S RE E Q+ E+ R L S
Sbjct: 1313 TQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEV 1372
Query: 466 ASLRADAE-----KAQEQQQQMAELHSKLQSSEAEVR---SKCEELSGLHGQLQEARAEN 517
A R E + +E ++ +L +LQ +E SKC L +LQ +
Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDL 1432
Query: 518 SQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAV 577
+ ER + A L+ Q + + + + D+ Q L+ + + L E ++R A
Sbjct: 1433 MRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAY 1492
Query: 578 EQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAK--------EESEKQLCLIEAQ 629
E+ + LR +N E ++ + E +L +A+ E+S+ Q+ L E +
Sbjct: 1493 EEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVE 1552
Query: 630 TM-----EALLALLPELS---------VLAQQNYTEWLQDLKEKGPTLLKHP-PAPAEPS 674
+L + ELS V+ + E L+ ++ L+ A
Sbjct: 1553 GSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSR 1612
Query: 675 SDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQ-----------------KSVE 717
+D ++ E + ++ + +AET+ LR +Q + ++
Sbjct: 1613 NDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLK 1672
Query: 718 EEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGEL-ESSDQVR----EHTS--HLEA 770
E+ + + G EEL++ +V ++ E + EL ++SD+V+ ++TS + +
Sbjct: 1673 EQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKK 1732
Query: 771 ELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVR-------Q 823
+LE +A AE +N +E + ++ + E +K+ D A + Q
Sbjct: 1733 KLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ 1792
Query: 824 QLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLE-----WTEAILEDEQTQRQ-- 876
+ +++ +++ + + E +L+ +L+ EA+ + +R+
Sbjct: 1793 TVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVK 1852
Query: 877 KLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEA-SQLKERLEKEKKLTSDLGRAAT 935
++T + EE + RLQ+ ++KL+ + EEA Q +L + +++ +L AA
Sbjct: 1853 EMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAE 1912
Query: 936 RLQELLKTTQEQLAREKDTVKKLQEQ 961
R + A+ +D + E+
Sbjct: 1913 RADIAESQVNKLRAKSRDVGSQKMEE 1938
Score = 91.7 bits (226), Expect = 3e-18
Identities = 125/559 (22%), Positives = 234/559 (41%), Gaps = 63/559 (11%)
Query: 436 LQASHRESEEALQKR-LDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEA 494
L+++ E E A K + EL +++ L EK Q+ +L ++QS
Sbjct: 844 LKSAEAEKEMATMKEDFERTKEELARSEARRKELE---EKMVSLLQEKNDLQLQVQSETE 900
Query: 495 EVRSKCEELSGLHGQLQEARAENSQLTERIRSIEAL----------LE---AGQARDAQD 541
+ E GL A+ +LTER+ E + LE + RD D
Sbjct: 901 NLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDD 960
Query: 542 VQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATA 601
++ + + ++++ E++V L +E L E + + + L+E + + ++ L
Sbjct: 961 LELTLTKVEKEK---HATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVE 1017
Query: 602 EQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGP 661
E +K++ L + + E+Q +E L +L ++ + DLK
Sbjct: 1018 E----DKVNGLIKINAKLEQQ-----TDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQE 1068
Query: 662 TLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEE-EE 720
+++ + KL++ E S LQA+ D + + + +++LQ +EE EE
Sbjct: 1069 SIMD----LENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEE 1124
Query: 721 QVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEK------ 774
++ A+ E Q+S + + LEEI E+L+ ++ E EAE +K
Sbjct: 1125 EIEAEHTLRAKIEKQRSDL-ARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLE 1183
Query: 775 -----HMAAASAECQNYAKEVAGLRQL---LLESQSQLDAAKSEAQKQSDELALVRQQLS 826
H A A+ + A VA L + L + +L+ KSE + + D++A + LS
Sbjct: 1184 EATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALS 1243
Query: 827 EMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQ 886
+ KS++E E ++ QL L +A L QTQ +L+ EE +
Sbjct: 1244 KSKSNIE-RTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARL---QTQNGELSHRVEEKE 1299
Query: 887 TSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQE 946
+ +L + + L T++ +LK ++E+E K + + A + +E
Sbjct: 1300 SLISQLTKSKQAL----------TQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLRE 1349
Query: 947 QLAREKDTVKKLQEQLEKA 965
Q E++ +LQ L KA
Sbjct: 1350 QYEEEQEAKAELQRALSKA 1368
Score = 76.3 bits (186), Expect = 1e-13
Identities = 94/494 (19%), Positives = 206/494 (41%), Gaps = 48/494 (9%)
Query: 129 QEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEA 188
Q +L ++ K+ + ++ K+ A VV+ ++ L + L+ E + Q E
Sbjct: 1468 QAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQ----EEISDLTEQIAET 1523
Query: 189 PK--QEAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAG 246
K QEA KK ++K L GS+ E E +++ + E +
Sbjct: 1524 GKNLQEAEKTKKLVEQEKSDLQV---------ALEEVEGSL---EHEESKILRVQLELSQ 1571
Query: 247 IIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAA 306
+ + K +K + + LKR + + L + + +++ L K+M + +
Sbjct: 1572 VKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEI 1631
Query: 307 GEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQ 366
+Q+ ++ + VQ +++ S L +R+ ++ E QLA ++
Sbjct: 1632 QLGHSNRQMAETQKHLRTVQGQLKDSQLH-------LDDALRSNEDLKE-----QLAIVE 1679
Query: 367 QENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKA 426
+ N +L + L E K E + + LS+ +EL++ S+ V+ Q +L
Sbjct: 1680 RRNGLLLEELE------EMKVALEQTERTRRLSE--QELLDASDRVQLLHSQNTSLINTK 1731
Query: 427 AAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELH 486
E + Q QA S + + ++ + + + A + + +K Q+ + +
Sbjct: 1732 KKLEADIAQCQAEVENSIQESRNAEEKAKKAI----TDAAMMAEELKKEQDTSAHLERMK 1787
Query: 487 SKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQ 546
L+ + +++ + +E L L+ + + +L R+R +E L+ Q R A+ ++
Sbjct: 1788 KNLEQTVKDLQHRLDEAEQL--ALKGGKKQIQKLENRVRELENELDVEQKRGAEALKG-- 1843
Query: 547 AEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACK 606
A + + ++KE+ Q K + L++ V++ + K + + +A E T C+
Sbjct: 1844 --AHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCR 1901
Query: 607 EKLHSLTQAKEESE 620
H L +A E ++
Sbjct: 1902 RVQHELEEAAERAD 1915
Score = 60.5 bits (145), Expect = 8e-09
Identities = 67/267 (25%), Positives = 124/267 (46%), Gaps = 27/267 (10%)
Query: 709 LRDLQKSVEEEEQVWRAKVG--AAEEELQKSRVTVKHLEE-IVEKLKGELESSDQVREHT 765
++ L KS E E+++ K +EEL +S K LEE +V L+ + + QV+ T
Sbjct: 840 IKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSET 899
Query: 766 SHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQ-SQLDAAKSEAQKQSDELALVRQQ 824
+L A C+ K ++LLE++ +L E ++ + EL ++
Sbjct: 900 ENL--------MDAEERCEGLIKS-----KILLEAKVKELTERLEEEEEMNSELVAKKRN 946
Query: 825 L----SEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTA 880
L S +K ++D ++ E E L ++ LE+ ++ K
Sbjct: 947 LEDKCSSLKRDIDDLELTLTKVEK-EKHATENKVKNLSEEM----TALEENISKLTKEKK 1001
Query: 881 EFEEA-QTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQE 939
+EA Q + LQ E +K+ + + ++ L+ LE+EKKL +DL RA +L+
Sbjct: 1002 SLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEG 1061
Query: 940 LLKTTQEQLAREKDTVKKLQEQLEKAE 966
LK +QE + ++ ++++E+L+K E
Sbjct: 1062 DLKMSQESIMDLENDKQQIEEKLKKKE 1088
Score = 37.0 bits (84), Expect = 0.090
Identities = 41/200 (20%), Positives = 91/200 (45%), Gaps = 8/200 (4%)
Query: 780 SAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAG 839
SAE + KE+A +++ ++ +L +++ ++ +++ + Q+ ++++ V+ +
Sbjct: 846 SAEAE---KEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQS-ETEN 901
Query: 840 APASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAE---FEEAQTSACRLQEEL 896
+ + + L+ +++ LE+E+ +L A+ E+ +S R ++L
Sbjct: 902 LMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDL 961
Query: 897 EKLRTAGPLESSETE-EASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTV 955
E T E TE + L E + ++ S L + LQE + T + L E+D V
Sbjct: 962 ELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKV 1021
Query: 956 KKLQEQLEKAEDGSSSKEGT 975
L + K E + EG+
Sbjct: 1022 NGLIKINAKLEQQTDDLEGS 1041
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 134 bits (337), Expect = 4e-31
Identities = 202/1011 (19%), Positives = 425/1011 (42%), Gaps = 90/1011 (8%)
Query: 33 MKETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKE--------EKPNGKIP 84
+K E+ +A ++E K + + + K K +E+K T KE + +
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905
Query: 85 DHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEK 144
D + + + + + A V I A + +++ + KD E
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 145 KVAKVEPAVSSVVNSIQVLTSKAAIL-ETAPKEGRNTDVAQSP--------EAPKQEAPA 195
+AKVE + N ++ LT + A L ET K + Q +A + +
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 196 KKKSGSK-KKGPPDADGPLYLPYK--------------TLVSTVGSMVFNEGEAQRLIEI 240
K+ K ++ D +G L K L S++ E E Q+L E
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 241 LSEK-------AGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLREL 293
L +K I+D Q + L+ ++EE E+ + E+ A A+ + +L
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1145
Query: 294 NKEM--AAEKAKAAAGEAKVKKQL-VAREQEITAVQARMQASYREHVKEVQQLQGK---- 346
++E+ +E+ + A G + ++ RE E ++ ++ + +H L+ K
Sbjct: 1146 SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADS 1205
Query: 347 IRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVE--SKQNAELAK----LRQELSK 400
+ L EQ++N + +L++E S ++ ++ S VE SK L K L +LS+
Sbjct: 1206 VAELGEQIDNLQRVK-QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSE 1264
Query: 401 VSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQA---SHRESEEALQKRLDEVSRE 457
+ + E+ + QR L+ ++ F +Q+ + +A ++A ++++E+ R+
Sbjct: 1265 LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ 1324
Query: 458 LCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAEN 517
L + +L + ++ + E + + Q S+AE++ LS + ++ + R +
Sbjct: 1325 LEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQ---RALSKANTEVAQWRTKY 1381
Query: 518 SQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAV 577
T+ I+ E L EA + + AQ +QA++ + + LE L+ E +L V
Sbjct: 1382 E--TDAIQRTEELEEA-KKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDV 1438
Query: 578 EQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLAL 637
E+ L +K + LA +Q C E+ H+ +A ++ + L + A
Sbjct: 1439 ERTNAACAALDKKQRNFDKILAEWKQKC-EETHAELEASQKEARSLGTELFKIKNAYEES 1497
Query: 638 LPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQ 697
L +L L ++N ++L+++ L + + +L ++ E+ + LQA ++
Sbjct: 1498 LDQLETLKREN-----KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEE 1552
Query: 698 YRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEEL-QKSRVTVKHLEEIVEKLKGELE 756
+ L EG + +Q + + + K+ +EE+ Q R ++ +E + L E+
Sbjct: 1553 AEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIR 1612
Query: 757 SSDQVREHTSHLEAELEK------HMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSE 810
S + +E +L + H +AE + G +L ++Q LD A
Sbjct: 1613 SRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQG---ILKDTQIHLDDALRS 1669
Query: 811 AQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILED 870
+ ++LA+V ++ + +++ +E+ A + AEQ+ + +++
Sbjct: 1670 QEDLKEQLAMVERRANLLQAEIEELR-ATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1728
Query: 871 EQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDL 930
++KL + + Q +++ L++ R A +A+ + E L+KE+ ++ L
Sbjct: 1729 LINTKKKLETDISQMQG---EMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1785
Query: 931 GRAATRLQELLKTTQ------EQLARE--KDTVKKLQEQLEKAEDGSSSKE 973
R +++ +K Q EQLA + K ++KL+ ++ + E S++
Sbjct: 1786 ERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQ 1836
Score = 123 bits (309), Expect = 7e-28
Identities = 180/895 (20%), Positives = 377/895 (42%), Gaps = 133/895 (14%)
Query: 148 KVEPAVSSVVNSIQVLTSKAAIL----ETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKK 203
K++P + S ++ T K E A E + ++ + K K+K+ +
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEE-----KMVTLLKEKNDLQL 895
Query: 204 KGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVA 263
+ +A+G L + + + + E + + + E ++ I + K + D +
Sbjct: 896 QVQAEAEG-LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECS 954
Query: 264 ILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEIT 323
LK+ +++ E LA +++ ++K++ L +EMA A ++T
Sbjct: 955 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIA---------------KLT 999
Query: 324 AVQARMQASYREHVKEVQQLQGKIRTLQE---QLENGPNTQLARLQQENSILRDALNQAT 380
+ +Q ++++ + ++Q + K+ TL + +LE + L+QE + D
Sbjct: 1000 KEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMD-----L 1054
Query: 381 SQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASH 440
+ + K +L ++ + + E + E +++ E + L++K + +QLQ
Sbjct: 1055 ERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKI 1114
Query: 441 RESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKC 500
+E LQ R++E+ E+ ++ AS RA AEK Q ++L +L+ E+ +
Sbjct: 1115 KE----LQARIEELEEEI---EAERAS-RAKAEK------QRSDLSRELE----EISERL 1156
Query: 501 EELSG-LHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKEL 559
EE G Q++ + ++ + R +E EA +A + AD + EL
Sbjct: 1157 EEAGGATSAQIEMNKKREAEFQKMRRDLE---EATLQHEATAATLRKKHADS----VAEL 1209
Query: 560 ESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEES 619
Q+ L++ +L + + K++ +DL +A E+ C+ L++ K +
Sbjct: 1210 GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKE 1269
Query: 620 EKQLCLIE----------------AQTMEALLALLPELSVLAQQNYTEWLQDLKE----- 658
E+Q LI ++ ++ AL+ +LS +Q +T+ +++LK
Sbjct: 1270 EEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLS-RGKQAFTQQIEELKRQLEEE 1328
Query: 659 -KGPTLLKHPPAPAEPSSD-LASKLREAEETQSTLQAECDQYRSILA------ETEGMLR 710
K L H + D L + E +E+++ LQ + + +A ET+ + R
Sbjct: 1329 IKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQR 1388
Query: 711 DLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEA 770
+ +EE ++ ++ AAEE ++ LE+ ++L+ E+E E T+ A
Sbjct: 1389 --TEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACA 1446
Query: 771 ELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVR-------- 822
L+K +N+ K +A +Q E+ ++L+A++ EA+ EL ++
Sbjct: 1447 ALDKKQ-------RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLD 1499
Query: 823 -------------QQLSEMKSHVEDGDIAGAPASSPE--APPAEQDPVQLKTQLEWTEAI 867
Q++S++ + +G G E EQ+ +L+ LE EA
Sbjct: 1500 QLETLKRENKNLQQEISDLTEQIAEG---GKRIHELEKIKKQVEQEKCELQAALEEAEAS 1556
Query: 868 LEDEQTQRQKLTAEFEEAQTSACR----LQEELEKL-----RTAGPLESSETEEASQLKE 918
LE E+ + ++ E + ++ R EE+++L R ++S+ E +
Sbjct: 1557 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616
Query: 919 RLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAEDGSSSKE 973
+ +KK+ DL +L + E L ++T L++ +D S+E
Sbjct: 1617 AIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQE 1671
Score = 97.1 bits (240), Expect = 7e-20
Identities = 164/743 (22%), Positives = 304/743 (40%), Gaps = 113/743 (15%)
Query: 209 ADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQ 268
A G L +TL + + E E QRLI L+ + G +Q T+ G+ RQ
Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ------TESGE----FSRQ 1296
Query: 269 LEEKEKLLATEQEDAAVAKSKLRELNKEMAAE-KAKAAAGEAKVKKQL---VAREQ--EI 322
L+EKE L++ ++ EL +++ E KAK A A + + REQ E
Sbjct: 1297 LDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEE 1356
Query: 323 TAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQ 382
+A +Q + + EV Q + K T Q + L++ L L A
Sbjct: 1357 QESKAELQRALSKANTEVAQWRTKYETDAIQ-------RTEELEEAKKKLAQRLQAAEEH 1409
Query: 383 VESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRE 442
VE+ NA+ A L + ++ E+ + V + AL+ K F+K + + + E
Sbjct: 1410 VEAV-NAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEE 1468
Query: 443 SE---EALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSK 499
+ EA QK + EL ++++ E + + + + + S L AE +
Sbjct: 1469 THAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKR 1528
Query: 500 CEELSGLHGQLQEARAE-NSQLTERIRSIE--------ALLEAGQARDAQDVQASQAEAD 550
EL + Q+++ + E + L E S+E LE Q + +V AE D
Sbjct: 1529 IHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKS--EVDRKIAEKD 1586
Query: 551 QQQTRLKE-----LESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQAC 605
++ +LK +ES S L+ E +A+ +K DL E + A A +A
Sbjct: 1587 EEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL 1646
Query: 606 KE-------------KLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEW 652
+ L +++E+ ++QL ++E + L A + EL +Q TE
Sbjct: 1647 RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRA-NLLQAEIEELRATLEQ--TER 1703
Query: 653 LQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRD- 711
+ + E+ LL D + +++ ++L + + +++ +G + D
Sbjct: 1704 SRKIAEQ--ELL-----------DASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDI 1750
Query: 712 LQKSVEEEEQVWRAKVGAA--EEELQKSRVTVKHLEEI-------VEKLKGELESSDQV- 761
LQ++ EE+ +A AA EEL+K + T HLE + V+ L+ L+ ++Q+
Sbjct: 1751 LQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLA 1810
Query: 762 ----REHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDE 817
++ LEA + + +E + A+ V GLR+ + ++ + ++
Sbjct: 1811 LKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRK----HERRVKELTYQTEEDRKN 1866
Query: 818 LALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQK 877
+ ++ + ++++ V+ K Q E E + +K
Sbjct: 1867 ILRLQDLVDKLQAKVKS----------------------YKRQAEEAEEQSNTNLAKFRK 1904
Query: 878 LTAEFEEAQTSACRLQEELEKLR 900
L E EEA+ A + ++ KLR
Sbjct: 1905 LQHELEEAEERADIAESQVNKLR 1927
Score = 47.4 bits (111), Expect = 7e-05
Identities = 59/288 (20%), Positives = 118/288 (40%), Gaps = 37/288 (12%)
Query: 696 DQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLE--EIVEKLKG 753
D+ ++ T+ R VE + V R + + +S + VKH ++ K+K
Sbjct: 785 DKLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKP 844
Query: 754 ELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQK 813
L+S AE EK MA E Q E+A KSEA++
Sbjct: 845 LLKS------------AETEKEMATMKEEFQKIKDELA----------------KSEAKR 876
Query: 814 QS--DELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDE 871
+ +++ + ++ ++++ V+ + G + + +QL+ +++ EDE
Sbjct: 877 KELEEKMVTLLKEKNDLQLQVQ-AEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDE 935
Query: 872 QTQRQKLTAEFEEAQTSACRLQEELEKLR-TAGPLESSETEEASQLKERLEKEKKLTSDL 930
+ +LTA+ + + L+++++ L T +E + +++K E+ L +
Sbjct: 936 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETI 995
Query: 931 GRAATR---LQELLKTTQEQLAREKDTVKKLQEQLEKAEDGSSSKEGT 975
+ LQE + T + L E+D V L + K E EG+
Sbjct: 996 AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGS 1043
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 134 bits (337), Expect = 4e-31
Identities = 202/1011 (19%), Positives = 425/1011 (42%), Gaps = 90/1011 (8%)
Query: 33 MKETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKE--------EKPNGKIP 84
+K E+ +A ++E K + + + K K +E+K T KE + +
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905
Query: 85 DHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEK 144
D + + + + + A V I A + +++ + KD E
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 145 KVAKVEPAVSSVVNSIQVLTSKAAIL-ETAPKEGRNTDVAQSP--------EAPKQEAPA 195
+AKVE + N ++ LT + A L ET K + Q +A + +
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 196 KKKSGSK-KKGPPDADGPLYLPYK--------------TLVSTVGSMVFNEGEAQRLIEI 240
K+ K ++ D +G L K L S++ E E Q+L E
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 241 LSEK-------AGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLREL 293
L +K I+D Q + L+ ++EE E+ + E+ A A+ + +L
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1145
Query: 294 NKEM--AAEKAKAAAGEAKVKKQL-VAREQEITAVQARMQASYREHVKEVQQLQGK---- 346
++E+ +E+ + A G + ++ RE E ++ ++ + +H L+ K
Sbjct: 1146 SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADS 1205
Query: 347 IRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVE--SKQNAELAK----LRQELSK 400
+ L EQ++N + +L++E S ++ ++ S VE SK L K L +LS+
Sbjct: 1206 VAELGEQIDNLQRVK-QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSE 1264
Query: 401 VSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQA---SHRESEEALQKRLDEVSRE 457
+ + E+ + QR L+ ++ F +Q+ + +A ++A ++++E+ R+
Sbjct: 1265 LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ 1324
Query: 458 LCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAEN 517
L + +L + ++ + E + + Q S+AE++ LS + ++ + R +
Sbjct: 1325 LEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQ---RALSKANTEVAQWRTKY 1381
Query: 518 SQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAV 577
T+ I+ E L EA + + AQ +QA++ + + LE L+ E +L V
Sbjct: 1382 E--TDAIQRTEELEEA-KKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDV 1438
Query: 578 EQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLAL 637
E+ L +K + LA +Q C E+ H+ +A ++ + L + A
Sbjct: 1439 ERTNAACAALDKKQRNFDKILAEWKQKC-EETHAELEASQKEARSLGTELFKIKNAYEES 1497
Query: 638 LPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQ 697
L +L L ++N ++L+++ L + + +L ++ E+ + LQA ++
Sbjct: 1498 LDQLETLKREN-----KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEE 1552
Query: 698 YRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEEL-QKSRVTVKHLEEIVEKLKGELE 756
+ L EG + +Q + + + K+ +EE+ Q R ++ +E + L E+
Sbjct: 1553 AEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIR 1612
Query: 757 SSDQVREHTSHLEAELEK------HMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSE 810
S + +E +L + H +AE + G +L ++Q LD A
Sbjct: 1613 SRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQG---ILKDTQIHLDDALRS 1669
Query: 811 AQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILED 870
+ ++LA+V ++ + +++ +E+ A + AEQ+ + +++
Sbjct: 1670 QEDLKEQLAMVERRANLLQAEIEELR-ATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1728
Query: 871 EQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDL 930
++KL + + Q +++ L++ R A +A+ + E L+KE+ ++ L
Sbjct: 1729 LINTKKKLETDISQMQG---EMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1785
Query: 931 GRAATRLQELLKTTQ------EQLARE--KDTVKKLQEQLEKAEDGSSSKE 973
R +++ +K Q EQLA + K ++KL+ ++ + E S++
Sbjct: 1786 ERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQ 1836
Score = 123 bits (309), Expect = 7e-28
Identities = 180/895 (20%), Positives = 377/895 (42%), Gaps = 133/895 (14%)
Query: 148 KVEPAVSSVVNSIQVLTSKAAIL----ETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKK 203
K++P + S ++ T K E A E + ++ + K K+K+ +
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEE-----KMVTLLKEKNDLQL 895
Query: 204 KGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVA 263
+ +A+G L + + + + E + + + E ++ I + K + D +
Sbjct: 896 QVQAEAEG-LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECS 954
Query: 264 ILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEIT 323
LK+ +++ E LA +++ ++K++ L +EMA A ++T
Sbjct: 955 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIA---------------KLT 999
Query: 324 AVQARMQASYREHVKEVQQLQGKIRTLQE---QLENGPNTQLARLQQENSILRDALNQAT 380
+ +Q ++++ + ++Q + K+ TL + +LE + L+QE + D
Sbjct: 1000 KEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMD-----L 1054
Query: 381 SQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASH 440
+ + K +L ++ + + E + E +++ E + L++K + +QLQ
Sbjct: 1055 ERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKI 1114
Query: 441 RESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKC 500
+E LQ R++E+ E+ ++ AS RA AEK Q ++L +L+ E+ +
Sbjct: 1115 KE----LQARIEELEEEI---EAERAS-RAKAEK------QRSDLSRELE----EISERL 1156
Query: 501 EELSG-LHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKEL 559
EE G Q++ + ++ + R +E EA +A + AD + EL
Sbjct: 1157 EEAGGATSAQIEMNKKREAEFQKMRRDLE---EATLQHEATAATLRKKHADS----VAEL 1209
Query: 560 ESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEES 619
Q+ L++ +L + + K++ +DL +A E+ C+ L++ K +
Sbjct: 1210 GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKE 1269
Query: 620 EKQLCLIE----------------AQTMEALLALLPELSVLAQQNYTEWLQDLKE----- 658
E+Q LI ++ ++ AL+ +LS +Q +T+ +++LK
Sbjct: 1270 EEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLS-RGKQAFTQQIEELKRQLEEE 1328
Query: 659 -KGPTLLKHPPAPAEPSSD-LASKLREAEETQSTLQAECDQYRSILA------ETEGMLR 710
K L H + D L + E +E+++ LQ + + +A ET+ + R
Sbjct: 1329 IKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQR 1388
Query: 711 DLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEA 770
+ +EE ++ ++ AAEE ++ LE+ ++L+ E+E E T+ A
Sbjct: 1389 --TEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACA 1446
Query: 771 ELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVR-------- 822
L+K +N+ K +A +Q E+ ++L+A++ EA+ EL ++
Sbjct: 1447 ALDKKQ-------RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLD 1499
Query: 823 -------------QQLSEMKSHVEDGDIAGAPASSPE--APPAEQDPVQLKTQLEWTEAI 867
Q++S++ + +G G E EQ+ +L+ LE EA
Sbjct: 1500 QLETLKRENKNLQQEISDLTEQIAEG---GKRIHELEKIKKQVEQEKCELQAALEEAEAS 1556
Query: 868 LEDEQTQRQKLTAEFEEAQTSACR----LQEELEKL-----RTAGPLESSETEEASQLKE 918
LE E+ + ++ E + ++ R EE+++L R ++S+ E +
Sbjct: 1557 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616
Query: 919 RLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAEDGSSSKE 973
+ +KK+ DL +L + E L ++T L++ +D S+E
Sbjct: 1617 AIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQE 1671
Score = 97.1 bits (240), Expect = 7e-20
Identities = 164/743 (22%), Positives = 304/743 (40%), Gaps = 113/743 (15%)
Query: 209 ADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQ 268
A G L +TL + + E E QRLI L+ + G +Q T+ G+ RQ
Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ------TESGE----FSRQ 1296
Query: 269 LEEKEKLLATEQEDAAVAKSKLRELNKEMAAE-KAKAAAGEAKVKKQL---VAREQ--EI 322
L+EKE L++ ++ EL +++ E KAK A A + + REQ E
Sbjct: 1297 LDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEE 1356
Query: 323 TAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQ 382
+A +Q + + EV Q + K T Q + L++ L L A
Sbjct: 1357 QESKAELQRALSKANTEVAQWRTKYETDAIQ-------RTEELEEAKKKLAQRLQAAEEH 1409
Query: 383 VESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRE 442
VE+ NA+ A L + ++ E+ + V + AL+ K F+K + + + E
Sbjct: 1410 VEAV-NAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEE 1468
Query: 443 SE---EALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSK 499
+ EA QK + EL ++++ E + + + + + S L AE +
Sbjct: 1469 THAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKR 1528
Query: 500 CEELSGLHGQLQEARAE-NSQLTERIRSIE--------ALLEAGQARDAQDVQASQAEAD 550
EL + Q+++ + E + L E S+E LE Q + +V AE D
Sbjct: 1529 IHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKS--EVDRKIAEKD 1586
Query: 551 QQQTRLKE-----LESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQAC 605
++ +LK +ES S L+ E +A+ +K DL E + A A +A
Sbjct: 1587 EEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL 1646
Query: 606 KE-------------KLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEW 652
+ L +++E+ ++QL ++E + L A + EL +Q TE
Sbjct: 1647 RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRA-NLLQAEIEELRATLEQ--TER 1703
Query: 653 LQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRD- 711
+ + E+ LL D + +++ ++L + + +++ +G + D
Sbjct: 1704 SRKIAEQ--ELL-----------DASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDI 1750
Query: 712 LQKSVEEEEQVWRAKVGAA--EEELQKSRVTVKHLEEI-------VEKLKGELESSDQV- 761
LQ++ EE+ +A AA EEL+K + T HLE + V+ L+ L+ ++Q+
Sbjct: 1751 LQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLA 1810
Query: 762 ----REHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDE 817
++ LEA + + +E + A+ V GLR+ + ++ + ++
Sbjct: 1811 LKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRK----HERRVKELTYQTEEDRKN 1866
Query: 818 LALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQK 877
+ ++ + ++++ V+ K Q E E + +K
Sbjct: 1867 ILRLQDLVDKLQAKVKS----------------------YKRQAEEAEEQSNTNLAKFRK 1904
Query: 878 LTAEFEEAQTSACRLQEELEKLR 900
L E EEA+ A + ++ KLR
Sbjct: 1905 LQHELEEAEERADIAESQVNKLR 1927
Score = 47.4 bits (111), Expect = 7e-05
Identities = 59/288 (20%), Positives = 118/288 (40%), Gaps = 37/288 (12%)
Query: 696 DQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLE--EIVEKLKG 753
D+ ++ T+ R VE + V R + + +S + VKH ++ K+K
Sbjct: 785 DKLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKP 844
Query: 754 ELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQK 813
L+S AE EK MA E Q E+A KSEA++
Sbjct: 845 LLKS------------AETEKEMATMKEEFQKIKDELA----------------KSEAKR 876
Query: 814 QS--DELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDE 871
+ +++ + ++ ++++ V+ + G + + +QL+ +++ EDE
Sbjct: 877 KELEEKMVTLLKEKNDLQLQVQ-AEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDE 935
Query: 872 QTQRQKLTAEFEEAQTSACRLQEELEKLR-TAGPLESSETEEASQLKERLEKEKKLTSDL 930
+ +LTA+ + + L+++++ L T +E + +++K E+ L +
Sbjct: 936 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETI 995
Query: 931 GRAATR---LQELLKTTQEQLAREKDTVKKLQEQLEKAEDGSSSKEGT 975
+ LQE + T + L E+D V L + K E EG+
Sbjct: 996 AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGS 1043
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 133 bits (335), Expect = 7e-31
Identities = 178/791 (22%), Positives = 345/791 (43%), Gaps = 119/791 (15%)
Query: 233 EAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLE-----EKEKLLATEQEDAAVAK 287
E L+ L E+ ++D + ++ +I K LE EK +++ E+ D A+
Sbjct: 423 EKVELLNQLEEEKRKVEDLQFRVEEE----SITKGDLEVATVSEKSRIMELEK-DLALRV 477
Query: 288 SKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQ--- 344
++ EL + + + K AG+ + L+ QEI+++Q +++ + +H +E+ L+
Sbjct: 478 QEVAELRRRLESNKP---AGDVDMSLSLL---QEISSLQEKLEVTRTDHQREITSLKEHF 531
Query: 345 -GKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQ---------------VESKQN 388
+ T Q++++ T +L +EN L+ L A + + S Q
Sbjct: 532 GAREETHQKEIK-ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQ 590
Query: 389 AELAKLRQELSK-VSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEAL 447
A + +L+ SK + E E +E Q E+ R + + + Q +A+H + EAL
Sbjct: 591 A-MEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL 649
Query: 448 QKRLDEVSRELCHTQSSHASLRADAEKAQEQQQ-QMAELHSKLQSSEAEVRSKCEELSGL 506
+ +L +V +E ++S ++R+ +KA++Q +M + +KLQ +E +V+ EL L
Sbjct: 650 RAKLMKVIKE---KENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK----ELEVL 702
Query: 507 HGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGL 566
+ E T ++++ E L D+ A + + + ++ +K+L Q+
Sbjct: 703 QAKCNEQTKVIDNFTSQLKATEEKL--------LDLDALRKASSEGKSEMKKLRQQLEAA 754
Query: 567 EKEA--IELREAVEQQKVKN--NDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQ 622
EK+ +E+ + E K + +L+ + K +E L ++Q KE EK+
Sbjct: 755 EKQIKHLEIEKNAESSKASSITRELQGRELKLTNL--------QENLSEVSQVKETLEKE 806
Query: 623 LCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPT---LLKHPPAPAEPSSDLAS 679
L +++ + EA E +V Q++ E + L +K L E +D+ +
Sbjct: 807 LQILKEKFAEA-----SEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEA 861
Query: 680 KLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEE---ELQK 736
K RE +E + L ++ + +AE M D + + R K EE +L K
Sbjct: 862 KFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK 921
Query: 737 SRVTVKHLEEIVEKLKGELESSDQV-----REHTSHLE---AELEKHMAAASAECQN--- 785
+ L++ +E + + E S Q E LE ++LEK M + +CQ
Sbjct: 922 ANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKA 981
Query: 786 ------------YAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVE 833
+ + + L++ LL+++ +L A+ E EL +R+Q + K+
Sbjct: 982 RYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKA--- 1038
Query: 834 DGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQ 893
+ A A Q Q+ + T A LED + KL E + + + +
Sbjct: 1039 ----------AQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNV 1088
Query: 894 EELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKD 953
EEL K + +E+ + EE ++ +E K+ + + + LQE E+L R +D
Sbjct: 1089 EELNKSKELLTVENQKMEE---FRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1145
Query: 954 TV---KKLQEQ 961
V +KL+E+
Sbjct: 1146 EVTSHQKLEEE 1156
Score = 107 bits (268), Expect = 4e-23
Identities = 157/754 (20%), Positives = 325/754 (43%), Gaps = 73/754 (9%)
Query: 253 HKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVK 312
H + D +A+ K +LE +A+ Q+ A+ + K+ +K + E A+ A + +++
Sbjct: 565 HANKENSDVIALWKSKLETA---IASHQQ--AMEELKV-SFSKGLGTETAEFAELKTQIE 618
Query: 313 KQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLEN---GPNTQLARLQQEN 369
K + + EI +Q + + H KE++ L+ K+ + ++ EN ++L + + ++
Sbjct: 619 KMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQH 678
Query: 370 SI-LRDALNQ-ATSQVESKQNAELAKLRQELSKV----SKELVEKSEAVRQDEQQRKALE 423
+ + D LN+ ++++ K+ L E +KV + +L E + + RKA
Sbjct: 679 LVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASS 738
Query: 424 AKAAAFEKQVLQLQASHRE------SEEALQKRLDEVSRELCHTQSSHASLRADAEKAQE 477
+ +K QL+A+ ++ + A + ++REL Q L E E
Sbjct: 739 EGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITREL---QGRELKLTNLQENLSE 795
Query: 478 QQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQAR 537
Q L +LQ + + EE + +QE + Q E+ + + LE
Sbjct: 796 VSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK-LRE 854
Query: 538 DAQDVQASQAEADQQQTRL----KELESQVSGLEK----EAIELREAVEQQKVKNNDLRE 589
+ D++A E D+++ +L ++LE+ ++ + K + +L + ++ ++K D+ E
Sbjct: 855 NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE 914
Query: 590 KNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNY 649
K +A A ++ + +T E+S+++ + + L L +L + ++
Sbjct: 915 LQLKLTKANENA-SFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSH 973
Query: 650 TEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLRE-AEETQSTLQAECDQYRSILAETEGM 708
+ Q+LK + +S+ +K E + Q TL D+ + E G+
Sbjct: 974 NQ-CQELKAR----------YERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGL 1022
Query: 709 LRDLQKSVEEEEQVWRAKVG-----AAEEELQKSRVTVKHLEEIVE---KLKGELESSDQ 760
L++L++ ++ ++ A+ E+ ++ T+ LE+ + KL+ EL D
Sbjct: 1023 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNEL---DT 1079
Query: 761 VREHTSHLEAELEKHMAAASAECQ---NYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDE 817
++E+ EL K + E Q + KE+ L+Q + QL A + E K ++E
Sbjct: 1080 LKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE 1139
Query: 818 LALVR------QQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDE 871
L R Q+L E +S + + + S A+++ L+ + T A+L ++
Sbjct: 1140 LGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1199
Query: 872 QTQRQKLTAE---FEEAQTSACRLQEELEKLRT-AGPLESSETEEASQLKERLEKEKKLT 927
+ +KL E SA L ++ L + LE QLK E +++L+
Sbjct: 1200 DAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLK---ENKRQLS 1256
Query: 928 SDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQ 961
S G T+ E + + Q+ + LQ +
Sbjct: 1257 SSSGNTDTQADEDERAQESQIDFLNSVIVDLQRK 1290
Score = 107 bits (266), Expect = 7e-23
Identities = 172/812 (21%), Positives = 347/812 (42%), Gaps = 129/812 (15%)
Query: 244 KAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAK 303
+ G++ +T + +K L+ L+EK++ + +++ AE+
Sbjct: 332 RTGLLTETSSRYARKISGTTALQEALKEKQQHI------------------EQLLAERDL 373
Query: 304 AAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLA 363
A AK + EQE+ A + + +HV E++ ++RT+ E + L
Sbjct: 374 ERAEVAKATSHVGEIEQEL----ALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLN 429
Query: 364 RLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDE--QQRKA 421
+L++E + D + + +K + E+A + E S++ + +EK A+R E + R+
Sbjct: 430 QLEEEKRKVEDLQFRVEEESITKGDLEVATV-SEKSRIME--LEKDLALRVQEVAELRRR 486
Query: 422 LEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQ 481
LE+ A + + + S + +LQ++L EV+R Q SL+ +E Q+
Sbjct: 487 LESNKPAGD---VDMSLSLLQEISSLQEKL-EVTR--TDHQREITSLKEHFGAREETHQK 540
Query: 482 MAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQD 541
++++ +E L +L+ A ENS + +S A + ++
Sbjct: 541 ------EIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEE 594
Query: 542 VQASQAEADQQQT-RLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEAL-A 599
++ S ++ +T EL++Q+ EK ++ + +E + + + R + K MEAL A
Sbjct: 595 LKVSFSKGLGTETAEFAELKTQI---EKMRLDYQHEIENLQNQQDSERAAHAKEMEALRA 651
Query: 600 TAEQACKEKLHSLTQAKEESEK----------------QLCLIEAQTMEALLALLPELSV 643
+ KEK +SL + + +K Q I+ + +E L A E +
Sbjct: 652 KLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTK 711
Query: 644 LAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQ-------AECD 696
+ N+T L+ +EK L A +E S++ ++ E + ++ AE
Sbjct: 712 VI-DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESS 770
Query: 697 QYRSILAETEGM-------------LRDLQKSVEEEEQVWRAKVGAAEEE---LQKS-RV 739
+ SI E +G + +++++E+E Q+ + K A EE +Q+S +
Sbjct: 771 KASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE 830
Query: 740 TVKHLEEIVEKLKGELESSDQVREHTSHLEA------ELEKHMAAASAECQNYAKEVAGL 793
TV L + E+ +++RE+ + +EA E E+ + A + +N ++A +
Sbjct: 831 TVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEN---DIAEI 887
Query: 794 RQLLLESQSQLDAAKSEAQ-KQSD------ELALVRQQLSEMKSHVEDGDIAGAPASSPE 846
++ ++ SQL E + K+ D +L + S ++ +ED + +
Sbjct: 888 MKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEA 947
Query: 847 APPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEEL---------- 896
A E++ +L+ +L E +E Q Q+L A +E A + EE+
Sbjct: 948 AKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD 1007
Query: 897 --EKLRTAGPLESSETEEASQLKERLEKEK-------------KLTSDLGRAATRLQELL 941
+KL+ A S +E +L+++ +K K ++T + L++
Sbjct: 1008 TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLED-T 1066
Query: 942 KTTQEQLAREKDTVKKLQEQLEKAEDGSSSKE 973
K T +L E DT+K + L+ E+ + SKE
Sbjct: 1067 KQTNAKLQNELDTLK--ENNLKNVEELNKSKE 1096
Score = 84.0 bits (206), Expect = 6e-16
Identities = 106/577 (18%), Positives = 259/577 (44%), Gaps = 57/577 (9%)
Query: 170 LETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVF 229
LE A K+ ++ ++ ++ E+ K + ++ G + K + ++
Sbjct: 751 LEAAEKQIKHLEIEKNAESSKASSITRELQGRELK-------------------LTNLQE 791
Query: 230 NEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSK 289
N E ++ E L ++ I+++ + +A+++ V +R ++E L ++E + S
Sbjct: 792 NLSEVSQVKETLEKELQILKEKFAEASEEAVSV---QRSMQETVNKLHQKEEQFNMLSSD 848
Query: 290 LRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRT 349
L +L + +A +AK + + ++QL+ ++++ A + ++ ++ ++ ++R
Sbjct: 849 LEKLRENLADMEAKFREKDER-EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL 907
Query: 350 LQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKS 409
+ +E +L + + S L+ ++ T + E Q K +E ++ ++L +
Sbjct: 908 KERDVEE-LQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLE 966
Query: 410 EAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLR 469
+ + Q + L+A+ +E+ + + H E + LQK L + +L + ++ L
Sbjct: 967 KKMETSHNQCQELKAR---YERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLL 1023
Query: 470 ADAEKAQEQQQQMAELHSK---LQSSEAEVRSKCEELSGLHGQLQ-EARAENSQLTERIR 525
+ E+ ++Q + + +Q E + K E L+ L Q A+ +N T +
Sbjct: 1024 QELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKEN 1083
Query: 526 SIEALLEAGQARDAQDVQASQAEADQQQTR-LKELESQ----VSGLEKEAIELREAV--- 577
+++ + E ++++ V+ + E +++ LK+ +Q +S L++E ++L E +
Sbjct: 1084 NLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRS 1143
Query: 578 -----------EQQKVKNNDLREKNWKAMEALATA--EQACKEKLHSLTQA---KEESEK 621
E++ V NN L E + + + A E+A +K S+T A ++++E
Sbjct: 1144 RDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAEL 1203
Query: 622 QLCLIEAQTMEALLALLPELSVLAQQNYTEWLQ-DLKEKGPTLLKHPPAPAEPSSDLASK 680
+ E + A L + Q ++ ++ +LK K L + + SS +
Sbjct: 1204 EKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL-QLKENKRQLSSSSGNT 1262
Query: 681 LREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVE 717
+A+E + +++ D S++ + + +DL+ VE
Sbjct: 1263 DTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVE 1299
Score = 71.2 bits (173), Expect = 4e-12
Identities = 132/601 (21%), Positives = 237/601 (39%), Gaps = 80/601 (13%)
Query: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM 482
+AKA A + + AS + S A L +S SS +S + E +
Sbjct: 290 KAKANAVRRVMATTSASLKRSPSA--SSLSSMSS----VASSVSSRPSRTGLLTETSSRY 343
Query: 483 AELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDV 542
A S + + ++ K + + L + RAE ++ T + IE E ARD D
Sbjct: 344 ARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ--ELALARDGHDQ 401
Query: 543 QASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAE 602
+ EA ++ +L + V ++E +EL +E++K K DL+ + E
Sbjct: 402 HVLELEA-----KMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFR--------VEEE 448
Query: 603 QACKEKLHSLTQAKE----ESEKQLCLIEAQTME---ALLALLPELSVLAQQNYTEWLQD 655
K L T +++ E EK L L + E L + P V + + +
Sbjct: 449 SITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISS 508
Query: 656 LKEK-GPTLLKHPPAPAEPSSDLASKLREAEET-QSTLQAECDQYRSILAETEGMLRDLQ 713
L+EK T H + L EET Q ++A + E E + L+
Sbjct: 509 LQEKLEVTRTDH----QREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLE 564
Query: 714 KSVEEEEQV---WRAKVGAAEEELQKS--RVTVKHLEEIVEKLKGELESSDQVREHTSHL 768
+ +E V W++K+ A Q++ + V + + + E Q+ +
Sbjct: 565 HANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDY 624
Query: 769 EAELEKHMAAASAECQNYAKEVAGLRQLLL----ESQSQLDAAKSEAQKQSDELALVRQQ 824
+ E+E +E +AKE+ LR L+ E ++ L+A +S+ K D+ + +
Sbjct: 625 QHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLV---E 681
Query: 825 LSEMKSHVEDGDIAGAPASSPEAPPAEQDPV--QLKTQLEWTEAILED----------EQ 872
+ + + +++ +I +A EQ V +QL+ TE L D +
Sbjct: 682 MEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGK 741
Query: 873 TQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETE----------------EASQL 916
++ +KL + E A+ L E+EK + S E E SQ+
Sbjct: 742 SEMKKLRQQLEAAEKQIKHL--EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQV 799
Query: 917 KERLEKE----KKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAEDGSSSK 972
KE LEKE K+ ++ A +Q ++ T +L ++++ L LEK + +
Sbjct: 800 KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADM 859
Query: 973 E 973
E
Sbjct: 860 E 860
Score = 54.7 bits (130), Expect = 4e-07
Identities = 81/397 (20%), Positives = 162/397 (40%), Gaps = 69/397 (17%)
Query: 129 QEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEA 188
QE ++KK+ E+K++ +E + + N Q L ++ T+ + ++ ++ Q+ +
Sbjct: 945 QEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYE-RATSETKTKHEEILQNLQK 1003
Query: 189 PKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGII 248
+ K K G+ N G Q L E+ +
Sbjct: 1004 TLLDTEDKLK--------------------------GAREENSGLLQELEELRKQ----- 1032
Query: 249 QDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGE 308
D A D + I+++ +EK + LA+ ED +KL+ + K
Sbjct: 1033 ADKAKAAQTAEDAMQIMEQMTKEKTETLAS-LEDTKQTNAKLQNELDTLKENNLKNVEEL 1091
Query: 309 AKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQE 368
K K+ L Q++ E KE++ L +Q + QL+ LQ+E
Sbjct: 1092 NKSKELLTVENQKM-----------EEFRKEIETL--------KQAAAQKSQQLSALQEE 1132
Query: 369 NSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAA 428
N L + L ++ +V S Q KL +E S ++ +L+E +++ + K + + A+
Sbjct: 1133 NVKLAEELGRSRDEVTSHQ-----KLEEERSVLNNQLLEMK---KRESKFIKDADEEKAS 1184
Query: 429 FEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSK 488
+K + A E + L+K +EV+ + +AS ++ Q + +L K
Sbjct: 1185 LQKSISITSALLTEKDAELEKLRNEVT----VLRGENASAKSLHSVVQTLESDKVKLELK 1240
Query: 489 LQSSEAEVRSKCEELSGLHGQL-----QEARAENSQL 520
+++ E +++ +LS G ++ RA+ SQ+
Sbjct: 1241 VKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI 1277
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 132 bits (333), Expect = 1e-30
Identities = 173/759 (22%), Positives = 328/759 (43%), Gaps = 115/759 (15%)
Query: 272 KEKLLATEQEDAAVA----KSKLRELNKEMAAEKAKAAAGEAKVKKQLVARE-------- 319
K L E ED VA KS++ EL K++A + A +++ A +
Sbjct: 479 KADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLL 538
Query: 320 QEITAVQARMQASYREHVKEVQQLQ----GKIRTLQEQLENGPNTQLARLQQENSILRDA 375
QEI+++Q +++ + +H +E+ L+ + T Q++++ T +L +EN L+
Sbjct: 539 QEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIK-ALYTATEKLSKENESLKSK 597
Query: 376 LNQATSQ---------------VESKQNAELAKLRQELSK-VSKELVEKSEAVRQDEQQR 419
L A + + S Q A + +L+ SK + E E +E Q E+ R
Sbjct: 598 LEHANKENSDVIALWKSKLETAIASHQQA-MEELKVSFSKGLGTETAEFAELKTQIEKMR 656
Query: 420 KALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQ 479
+ + + Q +A+H + EAL+ +L +V +E ++S ++R+ +KA++Q
Sbjct: 657 LDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE---KENSLEAIRSKLDKAEDQH 713
Query: 480 Q-QMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARD 538
+M + +KLQ +E +V+ EL L + E T ++++ E L
Sbjct: 714 LVEMEDTLNKLQEAEIKVK----ELEVLQAKCNEQTKVIDNFTSQLKATEEKL------- 762
Query: 539 AQDVQASQAEADQQQTRLKELESQVSGLEKEA--IELREAVEQQKVKN--NDLREKNWKA 594
D+ A + + + ++ +K+L Q+ EK+ +E+ + E K + +L+ + K
Sbjct: 763 -LDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKL 821
Query: 595 MEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQ 654
+E L ++Q KE EK+L +++ + EA E +V Q++ E +
Sbjct: 822 TNL--------QENLSEVSQVKETLEKELQILKEKFAEA-----SEEAVSVQRSMQETVN 868
Query: 655 DLKEKGPT---LLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRD 711
L +K L E +D+ +K RE +E + L ++ + +AE M D
Sbjct: 869 KLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGD 928
Query: 712 LQKSVEEEEQVWRAKVGAAEE---ELQKSRVTVKHLEEIVEKLKGELESSDQV-----RE 763
+ + R K EE +L K+ L++ +E + + E S Q E
Sbjct: 929 NSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE 988
Query: 764 HTSHLE---AELEKHMAAASAECQN---------------YAKEVAGLRQLLLESQSQLD 805
LE ++LEK M + +CQ + + + L++ LL+++ +L
Sbjct: 989 EKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLK 1048
Query: 806 AAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTE 865
A+ E EL +R+Q + K+ + A A Q Q+ + T
Sbjct: 1049 GAREENSGLLQELEELRKQADKAKA-------------AQTAEDAMQIMEQMTKEKTETL 1095
Query: 866 AILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKK 925
A LED + KL E + + + + EEL K + +E+ + EE ++ +E K+
Sbjct: 1096 ASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEE---FRKEIETLKQ 1152
Query: 926 LTSDLGRAATRLQELLKTTQEQLAREKDTV---KKLQEQ 961
+ + + LQE E+L R +D V +KL+E+
Sbjct: 1153 AAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEE 1191
Score = 107 bits (268), Expect = 4e-23
Identities = 157/754 (20%), Positives = 325/754 (43%), Gaps = 73/754 (9%)
Query: 253 HKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVK 312
H + D +A+ K +LE +A+ Q+ A+ + K+ +K + E A+ A + +++
Sbjct: 600 HANKENSDVIALWKSKLETA---IASHQQ--AMEELKV-SFSKGLGTETAEFAELKTQIE 653
Query: 313 KQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLEN---GPNTQLARLQQEN 369
K + + EI +Q + + H KE++ L+ K+ + ++ EN ++L + + ++
Sbjct: 654 KMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQH 713
Query: 370 SI-LRDALNQ-ATSQVESKQNAELAKLRQELSKV----SKELVEKSEAVRQDEQQRKALE 423
+ + D LN+ ++++ K+ L E +KV + +L E + + RKA
Sbjct: 714 LVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASS 773
Query: 424 AKAAAFEKQVLQLQASHRE------SEEALQKRLDEVSRELCHTQSSHASLRADAEKAQE 477
+ +K QL+A+ ++ + A + ++REL Q L E E
Sbjct: 774 EGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITREL---QGRELKLTNLQENLSE 830
Query: 478 QQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQAR 537
Q L +LQ + + EE + +QE + Q E+ + + LE
Sbjct: 831 VSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK-LRE 889
Query: 538 DAQDVQASQAEADQQQTRL----KELESQVSGLEK----EAIELREAVEQQKVKNNDLRE 589
+ D++A E D+++ +L ++LE+ ++ + K + +L + ++ ++K D+ E
Sbjct: 890 NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE 949
Query: 590 KNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNY 649
K +A A ++ + +T E+S+++ + + L L +L + ++
Sbjct: 950 LQLKLTKANENA-SFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSH 1008
Query: 650 TEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLRE-AEETQSTLQAECDQYRSILAETEGM 708
+ Q+LK + +S+ +K E + Q TL D+ + E G+
Sbjct: 1009 NQ-CQELKAR----------YERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGL 1057
Query: 709 LRDLQKSVEEEEQVWRAKVG-----AAEEELQKSRVTVKHLEEIVE---KLKGELESSDQ 760
L++L++ ++ ++ A+ E+ ++ T+ LE+ + KL+ EL D
Sbjct: 1058 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNEL---DT 1114
Query: 761 VREHTSHLEAELEKHMAAASAECQ---NYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDE 817
++E+ EL K + E Q + KE+ L+Q + QL A + E K ++E
Sbjct: 1115 LKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE 1174
Query: 818 LALVR------QQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDE 871
L R Q+L E +S + + + S A+++ L+ + T A+L ++
Sbjct: 1175 LGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1234
Query: 872 QTQRQKLTAE---FEEAQTSACRLQEELEKLRT-AGPLESSETEEASQLKERLEKEKKLT 927
+ +KL E SA L ++ L + LE QLK E +++L+
Sbjct: 1235 DAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLK---ENKRQLS 1291
Query: 928 SDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQ 961
S G T+ E + + Q+ + LQ +
Sbjct: 1292 SSSGNTDTQADEDERAQESQIDFLNSVIVDLQRK 1325
Score = 105 bits (263), Expect = 2e-22
Identities = 169/835 (20%), Positives = 349/835 (41%), Gaps = 140/835 (16%)
Query: 244 KAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAK 303
+ G++ +T + +K L+ L+EK++ + +++ AE+
Sbjct: 332 RTGLLTETSSRYARKISGTTALQEALKEKQQHI------------------EQLLAERDL 373
Query: 304 AAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLA 363
A AK + EQE+ A + + +HV E++ ++RT+ E + L
Sbjct: 374 ERAEVAKATSHVGEIEQEL----ALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLN 429
Query: 364 RLQQENSILRD--------ALNQATSQVESK-QNAELAKLRQEL-------SKVSKELVE 407
+L++E + D ++ + + ++K ++A + +L Q L K+ +EL +
Sbjct: 430 QLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELED 489
Query: 408 KSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEA--------LQKRLDEVSRELC 459
A ++ + LE A ++V +L+ ++ A L + + + +L
Sbjct: 490 TRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLE 549
Query: 460 HTQSSHASLRADAEKAQEQQQQMAELHSK-LQSSEAEVRSKCEELSGLHGQLQEARAENS 518
T++ H + + +E E H K +++ +E L +L+ A ENS
Sbjct: 550 VTRTDH---QREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENS 606
Query: 519 QLTERIRSIEALLEAGQARDAQDVQASQAEADQQQT-RLKELESQVSGLEKEAIELREAV 577
+ +S A + ++++ S ++ +T EL++Q+ EK ++ + +
Sbjct: 607 DVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQI---EKMRLDYQHEI 663
Query: 578 EQQKVKNNDLREKNWKAMEAL-ATAEQACKEKLHSLTQAKEESEK--------------- 621
E + + + R + K MEAL A + KEK +SL + + +K
Sbjct: 664 ENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK 723
Query: 622 -QLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASK 680
Q I+ + +E L A E + + N+T L+ +EK L A +E S++
Sbjct: 724 LQEAEIKVKELEVLQAKCNEQTKVI-DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKL 782
Query: 681 LREAEETQSTLQ-------AECDQYRSILAETEGM-------------LRDLQKSVEEEE 720
++ E + ++ AE + SI E +G + +++++E+E
Sbjct: 783 RQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL 842
Query: 721 QVWRAKVGAAEEE---LQKS-RVTVKHLEEIVEKLKGELESSDQVREHTSHLEA------ 770
Q+ + K A EE +Q+S + TV L + E+ +++RE+ + +EA
Sbjct: 843 QILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKD 902
Query: 771 ELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQ-KQSD------ELALVRQ 823
E E+ + A + +N ++A + ++ ++ SQL E + K+ D +L +
Sbjct: 903 EREEQLIKAKEKLEN---DIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANE 959
Query: 824 QLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFE 883
S ++ +ED + + A E++ +L+ +L E +E Q Q+L A +E
Sbjct: 960 NASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYE 1019
Query: 884 EAQTSACRLQEEL------------EKLRTAGPLESSETEEASQLKERLEKEK------- 924
A + EE+ +KL+ A S +E +L+++ +K K
Sbjct: 1020 RATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAED 1079
Query: 925 ------KLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAEDGSSSKE 973
++T + L++ K T +L E DT+K + L+ E+ + SKE
Sbjct: 1080 AMQIMEQMTKEKTETLASLED-TKQTNAKLQNELDTLK--ENNLKNVEELNKSKE 1131
Score = 84.0 bits (206), Expect = 6e-16
Identities = 106/577 (18%), Positives = 259/577 (44%), Gaps = 57/577 (9%)
Query: 170 LETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVF 229
LE A K+ ++ ++ ++ E+ K + ++ G + K + ++
Sbjct: 786 LEAAEKQIKHLEIEKNAESSKASSITRELQGRELK-------------------LTNLQE 826
Query: 230 NEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSK 289
N E ++ E L ++ I+++ + +A+++ V +R ++E L ++E + S
Sbjct: 827 NLSEVSQVKETLEKELQILKEKFAEASEEAVSV---QRSMQETVNKLHQKEEQFNMLSSD 883
Query: 290 LRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRT 349
L +L + +A +AK + + ++QL+ ++++ A + ++ ++ ++ ++R
Sbjct: 884 LEKLRENLADMEAKFREKDER-EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL 942
Query: 350 LQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKS 409
+ +E +L + + S L+ ++ T + E Q K +E ++ ++L +
Sbjct: 943 KERDVEE-LQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLE 1001
Query: 410 EAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLR 469
+ + Q + L+A+ +E+ + + H E + LQK L + +L + ++ L
Sbjct: 1002 KKMETSHNQCQELKAR---YERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLL 1058
Query: 470 ADAEKAQEQQQQMAELHSK---LQSSEAEVRSKCEELSGLHGQLQ-EARAENSQLTERIR 525
+ E+ ++Q + + +Q E + K E L+ L Q A+ +N T +
Sbjct: 1059 QELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKEN 1118
Query: 526 SIEALLEAGQARDAQDVQASQAEADQQQTR-LKELESQ----VSGLEKEAIELREAV--- 577
+++ + E ++++ V+ + E +++ LK+ +Q +S L++E ++L E +
Sbjct: 1119 NLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRS 1178
Query: 578 -----------EQQKVKNNDLREKNWKAMEALATA--EQACKEKLHSLTQA---KEESEK 621
E++ V NN L E + + + A E+A +K S+T A ++++E
Sbjct: 1179 RDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAEL 1238
Query: 622 QLCLIEAQTMEALLALLPELSVLAQQNYTEWLQ-DLKEKGPTLLKHPPAPAEPSSDLASK 680
+ E + A L + Q ++ ++ +LK K L + + SS +
Sbjct: 1239 EKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL-QLKENKRQLSSSSGNT 1297
Query: 681 LREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVE 717
+A+E + +++ D S++ + + +DL+ VE
Sbjct: 1298 DTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVE 1334
Score = 73.2 bits (178), Expect = 1e-12
Identities = 134/612 (21%), Positives = 245/612 (40%), Gaps = 99/612 (16%)
Query: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM 482
+AKA A + + AS + S A L +S SS +S + E +
Sbjct: 290 KAKANAVRRVMATTSASLKRSPSA--SSLSSMSS----VASSVSSRPSRTGLLTETSSRY 343
Query: 483 AELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDV 542
A S + + ++ K + + L + RAE ++ T + IE E ARD D
Sbjct: 344 ARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ--ELALARDGHDQ 401
Query: 543 QASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAE 602
+ EA ++ +L + V ++E +EL +E++K K DL+ + E
Sbjct: 402 HVLELEA-----KMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFR--------VEEE 448
Query: 603 QACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQ-DLKEKGP 661
K L + T+ + K+L E S+L ++ + LQ +L++
Sbjct: 449 SITKGDLETQTKLEHARIKEL----------------EQSLLFEKTKADKLQRELEDTRV 492
Query: 662 TLLKHPPAPAEPSSDLASKLREAEETQSTLQA-----ECDQYRSILAETEGMLRDLQKS- 715
+ E DLA +++E E + L++ + D S+L E + L+ +
Sbjct: 493 ATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTR 552
Query: 716 VEEEEQVWRAK--VGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHT-------- 765
+ + ++ K GA EE QK +K L EKL E ES EH
Sbjct: 553 TDHQREITSLKEHFGAREETHQKE---IKALYTATEKLSKENESLKSKLEHANKENSDVI 609
Query: 766 ----SHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALV 821
S LE + H A +++K + E ++Q++ + + Q + + L
Sbjct: 610 ALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQ-- 667
Query: 822 RQQLSEMKSHVEDGDIAGA--------PASSPEAPPAEQDPVQLKTQLEWTEAILEDEQT 873
QQ SE +H ++ + A +S EA ++ D + + +E + + + ++
Sbjct: 668 NQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA 727
Query: 874 QRQKLTAEFEEAQ-----------TSACRLQEE----LEKLRTAGPLESSETEEASQLKE 918
+ + E +A+ TS + EE L+ LR A SE ++ Q E
Sbjct: 728 EIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE 787
Query: 919 RLEKEKK-----LTSDLGRAATRLQEL------LKTTQEQLAREKDTVKKLQEQLE--KA 965
EK+ K ++ +A++ +EL L QE L+ + L+++L+ K
Sbjct: 788 AAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE 847
Query: 966 EDGSSSKEGTSV 977
+ +S+E SV
Sbjct: 848 KFAEASEEAVSV 859
Score = 54.7 bits (130), Expect = 4e-07
Identities = 81/397 (20%), Positives = 162/397 (40%), Gaps = 69/397 (17%)
Query: 129 QEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEA 188
QE ++KK+ E+K++ +E + + N Q L ++ T+ + ++ ++ Q+ +
Sbjct: 980 QEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYE-RATSETKTKHEEILQNLQK 1038
Query: 189 PKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGII 248
+ K K G+ N G Q L E+ +
Sbjct: 1039 TLLDTEDKLK--------------------------GAREENSGLLQELEELRKQ----- 1067
Query: 249 QDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGE 308
D A D + I+++ +EK + LA+ ED +KL+ + K
Sbjct: 1068 ADKAKAAQTAEDAMQIMEQMTKEKTETLAS-LEDTKQTNAKLQNELDTLKENNLKNVEEL 1126
Query: 309 AKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQE 368
K K+ L Q++ E KE++ L +Q + QL+ LQ+E
Sbjct: 1127 NKSKELLTVENQKM-----------EEFRKEIETL--------KQAAAQKSQQLSALQEE 1167
Query: 369 NSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAA 428
N L + L ++ +V S Q KL +E S ++ +L+E +++ + K + + A+
Sbjct: 1168 NVKLAEELGRSRDEVTSHQ-----KLEEERSVLNNQLLEMK---KRESKFIKDADEEKAS 1219
Query: 429 FEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSK 488
+K + A E + L+K +EV+ + +AS ++ Q + +L K
Sbjct: 1220 LQKSISITSALLTEKDAELEKLRNEVT----VLRGENASAKSLHSVVQTLESDKVKLELK 1275
Query: 489 LQSSEAEVRSKCEELSGLHGQL-----QEARAENSQL 520
+++ E +++ +LS G ++ RA+ SQ+
Sbjct: 1276 VKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI 1312
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 132 bits (333), Expect = 1e-30
Identities = 221/1001 (22%), Positives = 413/1001 (41%), Gaps = 150/1001 (14%)
Query: 40 EALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREP 99
E A +++E+A+ Q++EK+++ + + ++E + +L E
Sbjct: 1680 EEQAVRQRELAE---QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736
Query: 100 VRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNS 159
R A A T + + A +A V A + LAS + +++ K + + +
Sbjct: 1737 ARLQREAAAATQKRQEL-EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1795
Query: 160 IQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKT 219
+ L +AA L +E + +A +Q A A++ K +A T
Sbjct: 1796 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA---------T 1846
Query: 220 LVSTVGSMVFNEGEAQ--RLIEILSEKAGII-----QDTWHKAT---------------- 256
+ T + E EA+ RL + ++A Q HKA
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 257 --QKG--DPVAILKRQLEEKEKLLATEQEDAAVAKSKL-----------------RELNK 295
QKG + +RQ+EE+ L E AA K++L +E +
Sbjct: 1907 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 296 EMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKI---RTLQE 352
AA + + AA E + +++ R Q+ A + + ++EV++L+ K+ R L+E
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 353 QLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAV 412
+ E QL Q+ A +A + ++ EL + Q+ V +L ++EA
Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2086
Query: 413 R----QDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDE--VSRELCHTQSSHA 466
R + E+ R E +AA +QV + + + +EE Q R + +L A
Sbjct: 2087 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 467 SLRADAEKAQEQQQQMA--ELHSKLQSSEAEVRSKCE---ELSGLHGQLQEARAENSQLT 521
+ RA AE+A +Q+Q A E+ + +E +R K + EL+ L QL+E + + L
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 522 ERIRSIEALLEAGQA-RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQ 580
E ++ ++A EA +A R V+ Q L +L++++ E A+ LR+ Q
Sbjct: 2207 EELQRLKA--EATEAARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQ 2263
Query: 581 KVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPE 640
+ + EK + E A A +E A+E+ +Q L E E + A+
Sbjct: 2264 RFLQEEA-EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322
Query: 641 LSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQS---TLQAECDQ 697
+ A+ + ++L ++ L+ E +A +L AEETQ TL+AE +
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQ------EDKEQMAQQL--AEETQGFQRTLEAERQR 2374
Query: 698 YRSILAETEGM------LRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKL 751
+ AE E + + Q EE+ Q +R + E+L ++ + + +V+ L
Sbjct: 2375 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2434
Query: 752 KGELESSD----QVREHTSHLEAELEK-HMAAASAECQNYAKEVAGLRQLLLESQSQLDA 806
+ + + SD ++RE + LE E EK A + ++ + QLL E+Q+ +
Sbjct: 2435 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2494
Query: 807 AKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEA 866
SE + Q+ ++++ +D ++A A QL+ + + +
Sbjct: 2495 FLSEKDSLLQRERFIEQEKAKLEQLFQD-EVAKAQ--------------QLREEQQRQQQ 2539
Query: 867 ILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKL 926
+E E RQ+L A EEA+ +E + + + EE QL+++
Sbjct: 2540 QMEQE---RQRLVASMEEARRRQHEAEEGVRR----------KQEELQQLEQQ------- 2579
Query: 927 TSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAED 967
+ QE+L E++ ++L+EQL+ E+
Sbjct: 2580 ---------------RRQQEELLAEEN--QRLREQLQLLEE 2603
Score = 131 bits (329), Expect = 4e-30
Identities = 191/766 (24%), Positives = 334/766 (43%), Gaps = 108/766 (14%)
Query: 267 RQLEEKEKLL----ATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEI 322
R++EE+E+L A E+E A ++ L E +++A A+A A + K+L R QE
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAAL-EKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400
Query: 323 T------AVQARMQA-SYREHVKEVQQL-QGKIRTLQEQLENGPNTQLARLQQENSILRD 374
AV A+ Q S +E +++++Q + +I+ Q E ++L R+++E ++R
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVVRL 1459
Query: 375 ALNQATSQVESKQNAELAKLR---QELSKVSKELVEKSEAVR---QDEQQRKA------- 421
L +AT + EL LR +E ++ E++E +R QDE QRK
Sbjct: 1460 QL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518
Query: 422 ----LEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHT---------QSSHASL 468
EA+AA +++ LQ R E ++RL + E +S+ A L
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1578
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTER--IRS 526
++ E+ Q+ + + A++R + E + + + AR E + ER +++
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638
Query: 527 IEALLEAGQARD-AQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNN 585
EAL QA + AQ +QAEA++Q+ + + E++A+ RE EQ+ K
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 586 DLREKNWKAMEALATAEQ--ACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSV 643
L E TA+Q A +++L L E+ E+Q L+E + LA L +
Sbjct: 1699 QLAE---------GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAA 1744
Query: 644 LAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQST-------LQAECD 696
A Q E +L + AE LASK R EE++ST L+AE
Sbjct: 1745 AATQKRQELEAELAK----------VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794
Query: 697 QYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELE 756
++R LAE LR L + + + Q+ A+ AA + + RV + L I E + + E
Sbjct: 1795 RFRE-LAEEAARLRALAEEAKRQRQL--AEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851
Query: 757 SSDQVREHTSHLEAELEKHMAAASAEC-----------QNYAKEVAGLRQLLLESQSQLD 805
+ ++E EAE E+ A E Q+ A L QL S S+L+
Sbjct: 1852 AEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1907
Query: 806 AAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSP--EAPPAEQDPVQLKTQLEW 863
K + + V +++ +K+ E A +D ++ K Q E
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967
Query: 864 TEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKE 923
A + ++ E EE + +EE + R A EE +LK ++E+
Sbjct: 1968 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA------LEEVERLKAKVEEA 2021
Query: 924 KKLTSDLGR-AATRLQELLKTTQEQLAREKD----TVKKLQEQLEK 964
++L + +A +LQ + Q++L E+ V++ +++L++
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2067
Score = 125 bits (313), Expect = 3e-28
Identities = 182/812 (22%), Positives = 335/812 (41%), Gaps = 111/812 (13%)
Query: 231 EGEAQRLIEILSEKA--GIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKS 288
E E R +++ E A + K + A L+R L+E+ +A +E+A
Sbjct: 1556 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE---- 1611
Query: 289 KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIR 348
R ++ AE+A+ A + QL A E A++ R+QA K + Q +
Sbjct: 1612 --RRAQQQAEAERAREEAERELERWQLKANE----ALRLRLQAEEVAQQKSLAQAEA--- 1662
Query: 349 TLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEK 408
++Q E R + E +R A ++E ++ +Q L+ +EL+
Sbjct: 1663 --EKQKEEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLAEGTAQQRLA-AEQELIRL 1718
Query: 409 SEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASL 468
Q EQQR+ LE + A +++ +E E L K E+ L +
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1778
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERI--RS 526
R+ +EK++++ + A +L A +R+ EE +E A ER+
Sbjct: 1779 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1838
Query: 527 IEALLEAGQARDAQDVQASQAEADQ------------QQTRLKELESQ-VSGLEKEAIEL 573
+ A+ EA + + ++ + EA+ Q+ RL+E +Q + +E+ +L
Sbjct: 1839 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1898
Query: 574 REAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEA 633
R+A + + + L E + + A K K E E +L I + +
Sbjct: 1899 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1958
Query: 634 LLAL-LPELSVLAQ-QNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTL 691
L + EL Q Q E + +E + K A E + + L E E ++ +
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018
Query: 692 Q--------AECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKH 743
+ AE + R + E QK ++ EE+ V E+ELQ+ T++
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEA----AQKRLQAEEKAHAFAVQQKEQELQQ---TLQQ 2071
Query: 744 LEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAA------------SAECQNYAKEVA 791
+ ++++L+GE E++ + E + E+ A + SAE Q A+ A
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2131
Query: 792 GLRQLLLESQSQLDAAKSEAQKQSDELALVRQQL--SEMKSHVEDGDIAGAPASSPEAPP 849
L +++ +AA+ + Q+++ AL ++Q +EM+ H + A + +
Sbjct: 2132 QAAAEKLRKEAEQEAAR---RAQAEQAALRQKQAADAEMEKHKK-----FAEQTLRQKAQ 2183
Query: 850 AEQDPVQLKTQLEWT--EAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLES 907
EQ+ L+ QLE T + L DE+ QR L AE EA +++EEL +R
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQR--LKAEATEAARQRSQVEEELFSVRV------ 2235
Query: 908 SETEEASQLKERLEKE-----------------------KKLTSDLGRAATRLQE---LL 941
+ EE S+LK R+E E K++ + R + QE L
Sbjct: 2236 -QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294
Query: 942 KTTQEQLAREKDTVKK-LQEQLEKAEDGSSSK 972
+ +E LA+++ +K L+E+++ ++ + K
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2326
Score = 120 bits (302), Expect = 5e-27
Identities = 226/1009 (22%), Positives = 419/1009 (41%), Gaps = 122/1009 (12%)
Query: 35 ETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKK--EEKPNGKIPDHDPAPNV 92
E +E ++E+ + V+ ++++++++++ + ++ E + K + A
Sbjct: 1387 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1446
Query: 93 TVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPA 152
+ + E +R + + T Q + + A +E A + +++ E+ +V+
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506
Query: 153 VSSVVNSIQVLTSKA-AILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADG 211
+ L S+ A E A ++ R + +EA + + ++
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQV 1565
Query: 212 PLYLPYKTLVSTVGSM--VFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQL 269
L ++ + + S F E AQ L L E+ + +A ++ A +R
Sbjct: 1566 ALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624
Query: 270 EEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
EE E+ L Q A A +LR +E+A +K+ A A EA+ +K+ RE AR
Sbjct: 1625 EEAERELERWQLKANEAL-RLRLQAEEVAQQKSLAQA-EAEKQKEEAERE-------ARR 1675
Query: 330 QASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNA 389
+ E ++L + Q QL G Q +QE LR Q Q + +
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE- 1734
Query: 390 ELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQK 449
ELA+L++E + +++ E + + + + L A A E++ ++ EA
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794
Query: 450 RLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQ 509
R E++ E A LRA AE+A+ +Q+Q+AE + Q +EAE R E+L+ +
Sbjct: 1795 RFRELAEEA-------ARLRALAEEAK-RQRQLAEEDAARQRAEAE-RVLAEKLAAIGEA 1845
Query: 510 ----------LQEARAENSQLTERIRSIEAL----LEAGQARDAQDVQ--------ASQA 547
L+E AEN +L R+ EA LE A+ D++ AS +
Sbjct: 1846 TRLKTEAEIALKEKEAENERL-RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904
Query: 548 EADQQQTRLKELESQVSGLEKEAIELREAVEQQ------------KVKNN---DLREKNW 592
E ++Q+ +++ Q +E+E + L+ + E+ ++++N LR K
Sbjct: 1905 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1964
Query: 593 KAMEA-----LATAEQA----CKEKLHSLTQAKEESEKQ--LCLIEAQTMEALLALLPEL 641
+EA LA E+ +E++ A+EE+ +Q L E + ++A + L
Sbjct: 1965 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2024
Query: 642 SVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSI 701
A+Q LQ +E L+ AE + + ++ +E Q TLQ E +S+
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQ-----AEEKAHAFAVQQKEQELQQTLQQE----QSV 2075
Query: 702 LAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQV 761
L + G +++ EE E+ A+V A E Q R E E+LK E Q
Sbjct: 2076 LDQLRGEAEAARRAAEEAEE---ARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQA 2127
Query: 762 REHTSHLEAELEKHMAAASAECQNYAK-EVAGLRQLLLESQSQLDAAKSEAQKQSDELAL 820
R + +A EK A E A+ E A LRQ + ++++ K A++ + A
Sbjct: 2128 R---AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAEQTLRQKAQ 2183
Query: 821 VRQQLSEMKSHVEDGDIAG------APASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQ 874
V Q+L+ ++ +E+ D EA A + Q++ +L +E+
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2243
Query: 875 RQKLTAE-----FEEAQTSACRLQEELEKLRT--------------AGPLESSETEEASQ 915
+ ++ AE + + LQEE EK++ A L E+ +Q
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303
Query: 916 LKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEK 964
+ EK K + ATRL+ + Q+Q ++ ++LQE E+
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Score = 113 bits (283), Expect = 8e-25
Identities = 192/851 (22%), Positives = 366/851 (43%), Gaps = 106/851 (12%)
Query: 183 AQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLV---STVGSMVFNE-GEAQRLI 238
AQ+ A E A K S K + +A P + + + VG + GE +
Sbjct: 1115 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1174
Query: 239 EILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMA 298
E E+ + + W + D + +R+LE+ + L +E A + L++ +
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1231
Query: 299 AEKAKAAAGEAKVKKQLVAREQEITAVQAR------MQASYREHVKEVQQLQGKIRTLQE 352
+A A V++QL + + ++ Q ++++ ++ + ++ T +
Sbjct: 1232 QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1291
Query: 353 QLEN--GPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSE 410
QLE P + S++++ ++ T +EL L + K E + + E
Sbjct: 1292 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHY------SELTTLTSQYIKFISETLRRME 1345
Query: 411 -----AVRQDEQQRKALEAKAAAFEKQVLQLQASH--------RESEEALQKRLDEVSRE 457
A +Q ++R+ L AA EKQ QL +H RE++E Q+ +EV R
Sbjct: 1346 EEERLAEQQRAEERERLAEVEAALEKQ-RQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 458 LCHTQSSHASLRADAEKAQE-QQQQMAELHSKLQSSEAEVRSKC---EEL---------- 503
+ R+ E+ Q+ +Q AE+ +K + +EA RS+ EE+
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464
Query: 504 ----SGLHGQLQ--EARAENSQLTERIRSIEALL-------EAGQARDAQDVQASQAEAD 550
G G+LQ ARAE ++ +R EA E+ + R A+ AS+ +A+
Sbjct: 1465 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524
Query: 551 QQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLH 610
+ R E + + LE+ ++ EA +++++ ++ E+ + AL TA+++ + +L
Sbjct: 1525 AEAAR--EKQRALQALEELRLQAEEA--ERRLRQAEV-ERARQVQVALETAQRSAEAELQ 1579
Query: 611 SLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAP 670
S + E QL + A+ L E AQQ + +E+ L+
Sbjct: 1580 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE--AERAREEAERELERWQLK 1637
Query: 671 AEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAA 730
A + L + E + +S QAE ++ + E R+ ++ + EEQ R + A
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEK------QKEEAEREARRRGKAEEQAVRQR-ELA 1690
Query: 731 EEELQKSRVTVK-------HLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAEC 783
E+EL+K R + E+ + +L+ E E +Q R+ A L++ AAA+ +
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750
Query: 784 QNYAKEVAGLR---QLLLESQSQLD---AAKSEAQKQSDELALVR-QQLSEMKSHVEDGD 836
Q E+A +R ++LL S+++ + + SE KQ E R ++L+E + +
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR--- 1807
Query: 837 IAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEEL 896
A A + + AE+D + + + E +L ++ + T EA+ + + E
Sbjct: 1808 -ALAEEAKRQRQLAEEDAARQRAE---AERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 897 EKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVK 956
E+LR L E + +L+E+ + K +D+ RL +L K + +L R+K V+
Sbjct: 1864 ERLRR---LAEDEAFQRRRLEEQAAQHK---ADI---EERLAQLRKASDSELERQKGLVE 1914
Query: 957 KLQEQLEKAED 967
Q + E+
Sbjct: 1915 DTLRQRRQVEE 1925
Score = 111 bits (278), Expect = 3e-24
Identities = 176/765 (23%), Positives = 322/765 (42%), Gaps = 117/765 (15%)
Query: 266 KRQLEEK-EKLLATEQEDAAVAKSKLRELNKEMA----AEKAKAAAGEAKVKKQLVAREQ 320
+R+ EE+ +K LA E+E A K+ L E+ + A A + + A + ++ +A+E
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE- 2041
Query: 321 EITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQAT 380
A Q R+QA + H VQQ K + LQ+ L QQE S+L +A
Sbjct: 2042 ---AAQKRLQAEEKAHAFAVQQ---KEQELQQTL-----------QQEQSVLDQLRGEAE 2084
Query: 381 SQVESKQNAELAKLRQELSKV-SKELVEKSEAVRQ--DEQQRKALEAKAAA--FEKQVLQ 435
+ + + AE A+++ E S+ VE++E ++Q +EQ + +A+AAA K+ Q
Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144
Query: 436 LQASHRESEEALQKRLDEVSREL-CHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEA 494
A ++E+A ++ E+ H + + +LR +KAQ +Q+ + L +L+ ++
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR---QKAQVEQE-LTTLRLQLEETDH 2200
Query: 495 EVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLE--------------AGQARDAQ 540
+ EEL L + EA + SQ+ E + S+ +E A RD
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2260
Query: 541 DVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAM----- 595
+ Q E ++ ++ E +++S +EA LR+ E+ + L EK K
Sbjct: 2261 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320
Query: 596 ---------EALATAEQACKEKLHSLTQAKEESEKQLC--------------------LI 626
E L ++ +E+ L + KE+ +QL
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 627 EAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEE 686
EA+ ++ +A + A+++ + + +E G L + A E + L L E +
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTL-EIQR 2438
Query: 687 TQSTLQAECDQYRSILAETEGMLRDLQKSV-------EEEEQVWRAKVGAAEEELQKSRV 739
QS AE + R +AE E LQ+ EE + V + ++ + LQ+S +
Sbjct: 2439 QQSDHDAE--RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 740 TVK----HLEEIVEKLKGELES--------SDQVREHTSHLEAELEKHMAAASAECQNYA 787
+ K E +E+ K +LE + Q+RE + ++E+ A +
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556
Query: 788 KEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEA 847
+ + + Q +L + + ++Q + LA Q+L E +E+ A A A S E
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA-ALAHSEEV 2615
Query: 848 PPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLES 907
++ KT +A+ + + + + SA RLQE AG L +
Sbjct: 2616 TASQ--VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE-------AGILSA 2666
Query: 908 SETEEASQ---LKERLEKEKKLTSDLGRAATRLQELLKTTQEQLA 949
E + +Q + L + + + L ++ LLK T E+L+
Sbjct: 2667 EELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLS 2711
Score = 91.3 bits (225), Expect = 4e-18
Identities = 142/624 (22%), Positives = 248/624 (39%), Gaps = 69/624 (11%)
Query: 364 RLQQENSILRDALNQATSQVESKQNAE-LAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
RL + R+ + Q +++ E L K LS +++++ E R L
Sbjct: 1008 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1067
Query: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM 482
E E QV L A + E +L +S + TQ + LRA E+ +E Q
Sbjct: 1068 ELTLGKLE-QVRSLSAIYLE-------KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1119
Query: 483 AEL------HSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQA 536
A L + L+ A+ ++ L +L+ A+ +L +R + +E +
Sbjct: 1120 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1179
Query: 537 RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAME 596
R AQ ++ QA Q R +ELE L ++ RE+ + D R + +
Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRELEQ----LGRQLRYYRESADPLGAWLQDARRRQEQIQA 1235
Query: 597 ALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDL 656
QA +E+L EE E+ +E Q+ +++ +
Sbjct: 1236 MPLADSQAVREQLRQEQALLEEIERHGEKVEE----------------CQRFAKQYINAI 1279
Query: 657 KEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSV 716
K+ L+ + A EP + A K + ++S +Q D R+ +E + K +
Sbjct: 1280 KDYELQLVTYK-AQLEPVASPAKKPKVQSGSESVIQEYVD-LRTHYSELTTLTSQYIKFI 1337
Query: 717 EEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHM 776
E T++ +EE E+ E + +++ RE + +EA LEK
Sbjct: 1338 SE---------------------TLRRMEE--EERLAEQQRAEE-RERLAEVEAALEKQR 1373
Query: 777 AAASAECQNYA---KEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVE 833
A A Q A +E L+Q + E + + A +AQ+Q + QQL +
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1433
Query: 834 DGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQ 893
A A+ E++ ++ QLE TE + + Q L A EEA+ + Q
Sbjct: 1434 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1493
Query: 894 EELEKLRTAGPLESSETEEAS-QLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAR-- 950
EE E+LR ES +A +L R++ E + + RA L+EL +E R
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1553
Query: 951 --EKDTVKKLQEQLEKAEDGSSSK 972
E + +++Q LE A+ + ++
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAE 1577
Score = 76.3 bits (186), Expect = 1e-13
Identities = 119/582 (20%), Positives = 255/582 (43%), Gaps = 45/582 (7%)
Query: 143 EKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSK 202
++K +++ + + + L +A A +E V EA + ++ K
Sbjct: 2059 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2118
Query: 203 KKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDT-----WHKATQ 257
+ A + + E E + +E+A + Q K +
Sbjct: 2119 QSAEEQAQA------RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2172
Query: 258 KGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVA 317
+ K Q+E++ L + E+ K+ L E + + AE +AA ++V+++L +
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 318 ---REQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRD 374
+ +E++ ++AR++A R + ++ R LQE+ E ++ ++ +E + L
Sbjct: 2233 VRVQMEELSKLKARIEAENRALI--LRDKDNTQRFLQEEAE-----KMKQVAEEAARLSV 2285
Query: 375 ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVL 434
A +A +Q AE L Q+ + K L EK +AV+ E R EA+ +K++
Sbjct: 2286 AAQEAA---RLRQLAE-EDLAQQRALAEKMLKEKMQAVQ--EATRLKAEAELLQQQKELA 2339
Query: 435 QLQASH-RESEEALQKRLDEVSRELCHT----QSSHASLRADAEKAQEQQQQMAELHSKL 489
Q QA +E +E + ++L E ++ T + + A+AE+ + + +M+ ++
Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2399
Query: 490 QSSEAEVRSKCEELSGLHGQLQEARAENSQL--TERIRSIEALLEAGQARDAQDVQASQA 547
+ R + EE+ + + A E L T I+ ++ +A + R+A +
Sbjct: 2400 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2459
Query: 548 EADQQQTRLKELESQ--VSGLEKEAIELREAVEQQKVKNND-LREKNWKAMEALATAEQA 604
E QQ+ +L +L+S+ + +++ ++ +A++Q + D L ++ + A EQ
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2519
Query: 605 CKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLL 664
++++ Q +EE ++Q +E Q + L+A + E A++ E + ++ K L
Sbjct: 2520 FQDEVAKAQQLREEQQRQQQQME-QERQRLVASMEE----ARRRQHEAEEGVRRKQEELQ 2574
Query: 665 KHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETE 706
+ + LA E + + LQ +Q+R+ LA +E
Sbjct: 2575 QLEQQRRQQEELLA---EENQRLREQLQLLEEQHRAALAHSE 2613
Score = 52.4 bits (124), Expect = 2e-06
Identities = 169/750 (22%), Positives = 280/750 (37%), Gaps = 152/750 (20%)
Query: 295 KEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKI------- 347
KEM +A +K Q + E + A Q ++ Y H +V++ GK+
Sbjct: 325 KEMELPAKEADKNRSKGIYQSL--EGAVQAGQLKVPPGY--HPLDVEKEWGKLHVAILER 380
Query: 348 -RTLQEQLENGPNTQ--LARLQQENSILRDALNQATSQVESKQNAELA-KLRQELSKVSK 403
+ L+ + E Q + +LQ E + + LNQA + ++S A K+ Q +V +
Sbjct: 381 EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVER 440
Query: 404 ELVEKSEAVR---------------QDEQQRKAL----EAKAAAFEKQVLQLQAS-HRES 443
+L + +R Q EQ + + E A + L+L+A +
Sbjct: 441 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 500
Query: 444 EEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM--AELHSKLQSSEAEVRSKCE 501
+ Q L V R S+ L+ +E Q ++ AE L S EA++ S
Sbjct: 501 TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH-- 558
Query: 502 ELSGLHGQLQEARAENSQLTERIRSIEALLEA---GQARDAQ---DVQASQAEADQQQTR 555
GLH ++E RA+ ER RS E L G RD D+Q ++ + + R
Sbjct: 559 --RGLHQSIEEFRAK----IERARSDEGQLSPATRGAYRDCLGRLDLQYAKL-LNSSKAR 611
Query: 556 LKELESQ---VSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSL 612
L+ LES V+ KE + L E E++ D ++N T A KE +L
Sbjct: 612 LRSLESLHSFVAAATKELMWLNEKEEEEV--GFDWSDRN--------TNMTAKKESYSAL 661
Query: 613 TQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLK--HPPAP 670
+ E EK++ ++L+ G LL+ HP P
Sbjct: 662 MRELELKEKKI------------------------------KELQNAGDRLLREDHPARP 691
Query: 671 AEPSSDLASKLREAEETQSTLQAECD--------QYRSILAETEGMLRDLQKSVEEEEQV 722
S A + + + Q E Q+ S + E EG L+ LQ+++ +
Sbjct: 692 TVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSC 751
Query: 723 WRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAE 782
R+ TV LE++++ + E E Q+ E+ HL ++ A +
Sbjct: 752 DRS-------------ATVTRLEDLLQDAQDEKE---QLNEYKGHLSGLAKRAKAVVQLK 795
Query: 783 CQNYAKEVAGLRQLLLESQSQLDAAKSEAQ-KQSDELALV-RQQLSEMKSHVEDGDIAGA 840
++ A + G LL + D + E + DE LV Q S K G A
Sbjct: 796 PRHPAHPMRGRLPLL----AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAV 851
Query: 841 PASSPEAPPAEQDP----------------------VQLKTQLEWTEAILEDEQTQRQKL 878
P+ PP Q+ V +K+ L W +++ D Q R
Sbjct: 852 PSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW-QSLRRDVQLIRSWS 910
Query: 879 TAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQ 938
A F + R +L L S+ ++RL E++ S LQ
Sbjct: 911 LATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQ 970
Query: 939 ELLKTTQEQLAREK--DTVKKLQEQLEKAE 966
L + QE+ ++ +K ++ QLE E
Sbjct: 971 SLEQGAQEESRCQRCISELKDIRLQLEACE 1000
Score = 37.7 bits (86), Expect = 0.053
Identities = 109/534 (20%), Positives = 200/534 (37%), Gaps = 48/534 (8%)
Query: 39 EEALANQR---KEMAKTHHQKVEK------------KKKEKTVEKKGKTKKKEEKPNGKI 83
EE LA QR ++M K Q V++ ++KE E+ + ++ +E+ ++
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 84 PDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKE 143
+ T+ E R + ++ + + VA ++ A +E K ++
Sbjct: 2358 AEETQGFQRTL---EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414
Query: 144 KKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKK 203
+K+ + E A V +Q L + + + R E K + AK +
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474
Query: 204 KGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGI---IQDTWHKATQKGD 260
+ L + L + S + + +R IE EKA + QD KA Q +
Sbjct: 2475 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE--QEKAKLEQLFQDEVAKAQQLRE 2532
Query: 261 PVAILKRQLEEKEKLLATEQEDAA----VAKSKLRELNKEM-AAEKAKAAAGEAKVKKQL 315
++Q+E++ + L E+A A+ +R +E+ E+ + E ++
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2592
Query: 316 VAREQ-EITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRD 374
REQ ++ Q R ++ E V Q K +GP + + + R
Sbjct: 2593 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRK 2652
Query: 375 ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVL 434
Q + EL +L Q + V + + + E VR Q R ++ + L
Sbjct: 2653 VSAQRLQEAGILSAEELQRLAQGHTTVDE--LARREDVRHYLQGRSSIAGLLLKATNEKL 2710
Query: 435 QLQASHRESEEALQKRLDEVSRELCHTQSSHAS---------LRADAEKAQEQQQQMAEL 485
+ A ALQ++L L ++ AS R +A ++ EL
Sbjct: 2711 SVYA-------ALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPEL 2763
Query: 486 HSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTER-IRSIEALLEAGQARD 538
H KL S+E V + +G L +A + + E IR +EA + G D
Sbjct: 2764 HHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVID 2817
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 132 bits (333), Expect = 1e-30
Identities = 221/1001 (22%), Positives = 413/1001 (41%), Gaps = 150/1001 (14%)
Query: 40 EALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREP 99
E A +++E+A+ Q++EK+++ + + ++E + +L E
Sbjct: 1684 EEQAVRQRELAE---QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1740
Query: 100 VRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNS 159
R A A T + + A +A V A + LAS + +++ K + + +
Sbjct: 1741 ARLQREAAAATQKRQEL-EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1799
Query: 160 IQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKT 219
+ L +AA L +E + +A +Q A A++ K +A T
Sbjct: 1800 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA---------T 1850
Query: 220 LVSTVGSMVFNEGEAQ--RLIEILSEKAGII-----QDTWHKAT---------------- 256
+ T + E EA+ RL + ++A Q HKA
Sbjct: 1851 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1910
Query: 257 --QKG--DPVAILKRQLEEKEKLLATEQEDAAVAKSKL-----------------RELNK 295
QKG + +RQ+EE+ L E AA K++L +E +
Sbjct: 1911 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1970
Query: 296 EMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKI---RTLQE 352
AA + + AA E + +++ R Q+ A + + ++EV++L+ K+ R L+E
Sbjct: 1971 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2030
Query: 353 QLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAV 412
+ E QL Q+ A +A + ++ EL + Q+ V +L ++EA
Sbjct: 2031 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2090
Query: 413 R----QDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDE--VSRELCHTQSSHA 466
R + E+ R E +AA +QV + + + +EE Q R + +L A
Sbjct: 2091 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2150
Query: 467 SLRADAEKAQEQQQQMA--ELHSKLQSSEAEVRSKCE---ELSGLHGQLQEARAENSQLT 521
+ RA AE+A +Q+Q A E+ + +E +R K + EL+ L QL+E + + L
Sbjct: 2151 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2210
Query: 522 ERIRSIEALLEAGQA-RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQ 580
E ++ ++A EA +A R V+ Q L +L++++ E A+ LR+ Q
Sbjct: 2211 EELQRLKA--EATEAARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQ 2267
Query: 581 KVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPE 640
+ + EK + E A A +E A+E+ +Q L E E + A+
Sbjct: 2268 RFLQEEA-EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2326
Query: 641 LSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQS---TLQAECDQ 697
+ A+ + ++L ++ L+ E +A +L AEETQ TL+AE +
Sbjct: 2327 TRLKAEAELLQQQKELAQEQARRLQ------EDKEQMAQQL--AEETQGFQRTLEAERQR 2378
Query: 698 YRSILAETEGM------LRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKL 751
+ AE E + + Q EE+ Q +R + E+L ++ + + +V+ L
Sbjct: 2379 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2438
Query: 752 KGELESSD----QVREHTSHLEAELEK-HMAAASAECQNYAKEVAGLRQLLLESQSQLDA 806
+ + + SD ++RE + LE E EK A + ++ + QLL E+Q+ +
Sbjct: 2439 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2498
Query: 807 AKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEA 866
SE + Q+ ++++ +D ++A A QL+ + + +
Sbjct: 2499 FLSEKDSLLQRERFIEQEKAKLEQLFQD-EVAKAQ--------------QLREEQQRQQQ 2543
Query: 867 ILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKL 926
+E E RQ+L A EEA+ +E + + + EE QL+++
Sbjct: 2544 QMEQE---RQRLVASMEEARRRQHEAEEGVRR----------KQEELQQLEQQ------- 2583
Query: 927 TSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAED 967
+ QE+L E++ ++L+EQL+ E+
Sbjct: 2584 ---------------RRQQEELLAEEN--QRLREQLQLLEE 2607
Score = 131 bits (329), Expect = 4e-30
Identities = 191/766 (24%), Positives = 334/766 (43%), Gaps = 108/766 (14%)
Query: 267 RQLEEKEKLL----ATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEI 322
R++EE+E+L A E+E A ++ L E +++A A+A A + K+L R QE
Sbjct: 1346 RRMEEEERLAEQQRAEERERLAEVEAAL-EKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1404
Query: 323 T------AVQARMQA-SYREHVKEVQQL-QGKIRTLQEQLENGPNTQLARLQQENSILRD 374
AV A+ Q S +E +++++Q + +I+ Q E ++L R+++E ++R
Sbjct: 1405 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVVRL 1463
Query: 375 ALNQATSQVESKQNAELAKLR---QELSKVSKELVEKSEAVR---QDEQQRKA------- 421
L +AT + EL LR +E ++ E++E +R QDE QRK
Sbjct: 1464 QL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1522
Query: 422 ----LEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHT---------QSSHASL 468
EA+AA +++ LQ R E ++RL + E +S+ A L
Sbjct: 1523 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1582
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTER--IRS 526
++ E+ Q+ + + A++R + E + + + AR E + ER +++
Sbjct: 1583 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1642
Query: 527 IEALLEAGQARD-AQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNN 585
EAL QA + AQ +QAEA++Q+ + + E++A+ RE EQ+ K
Sbjct: 1643 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1702
Query: 586 DLREKNWKAMEALATAEQ--ACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSV 643
L E TA+Q A +++L L E+ E+Q L+E + LA L +
Sbjct: 1703 QLAE---------GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAA 1748
Query: 644 LAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQST-------LQAECD 696
A Q E +L + AE LASK R EE++ST L+AE
Sbjct: 1749 AATQKRQELEAELAK----------VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1798
Query: 697 QYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELE 756
++R LAE LR L + + + Q+ A+ AA + + RV + L I E + + E
Sbjct: 1799 RFRE-LAEEAARLRALAEEAKRQRQL--AEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1855
Query: 757 SSDQVREHTSHLEAELEKHMAAASAEC-----------QNYAKEVAGLRQLLLESQSQLD 805
+ ++E EAE E+ A E Q+ A L QL S S+L+
Sbjct: 1856 AEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1911
Query: 806 AAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSP--EAPPAEQDPVQLKTQLEW 863
K + + V +++ +K+ E A +D ++ K Q E
Sbjct: 1912 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1971
Query: 864 TEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKE 923
A + ++ E EE + +EE + R A EE +LK ++E+
Sbjct: 1972 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA------LEEVERLKAKVEEA 2025
Query: 924 KKLTSDLGR-AATRLQELLKTTQEQLAREKD----TVKKLQEQLEK 964
++L + +A +LQ + Q++L E+ V++ +++L++
Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2071
Score = 125 bits (313), Expect = 3e-28
Identities = 182/812 (22%), Positives = 335/812 (41%), Gaps = 111/812 (13%)
Query: 231 EGEAQRLIEILSEKA--GIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKS 288
E E R +++ E A + K + A L+R L+E+ +A +E+A
Sbjct: 1560 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE---- 1615
Query: 289 KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIR 348
R ++ AE+A+ A + QL A E A++ R+QA K + Q +
Sbjct: 1616 --RRAQQQAEAERAREEAERELERWQLKANE----ALRLRLQAEEVAQQKSLAQAEA--- 1666
Query: 349 TLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEK 408
++Q E R + E +R A ++E ++ +Q L+ +EL+
Sbjct: 1667 --EKQKEEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLAEGTAQQRLA-AEQELIRL 1722
Query: 409 SEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASL 468
Q EQQR+ LE + A +++ +E E L K E+ L +
Sbjct: 1723 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1782
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERI--RS 526
R+ +EK++++ + A +L A +R+ EE +E A ER+
Sbjct: 1783 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1842
Query: 527 IEALLEAGQARDAQDVQASQAEADQ------------QQTRLKELESQ-VSGLEKEAIEL 573
+ A+ EA + + ++ + EA+ Q+ RL+E +Q + +E+ +L
Sbjct: 1843 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1902
Query: 574 REAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEA 633
R+A + + + L E + + A K K E E +L I + +
Sbjct: 1903 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1962
Query: 634 LLAL-LPELSVLAQ-QNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTL 691
L + EL Q Q E + +E + K A E + + L E E ++ +
Sbjct: 1963 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2022
Query: 692 Q--------AECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKH 743
+ AE + R + E QK ++ EE+ V E+ELQ+ T++
Sbjct: 2023 EEARRLRERAEQESARQLQLAQEA----AQKRLQAEEKAHAFAVQQKEQELQQ---TLQQ 2075
Query: 744 LEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAA------------SAECQNYAKEVA 791
+ ++++L+GE E++ + E + E+ A + SAE Q A+ A
Sbjct: 2076 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2135
Query: 792 GLRQLLLESQSQLDAAKSEAQKQSDELALVRQQL--SEMKSHVEDGDIAGAPASSPEAPP 849
L +++ +AA+ + Q+++ AL ++Q +EM+ H + A + +
Sbjct: 2136 QAAAEKLRKEAEQEAAR---RAQAEQAALRQKQAADAEMEKHKK-----FAEQTLRQKAQ 2187
Query: 850 AEQDPVQLKTQLEWT--EAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLES 907
EQ+ L+ QLE T + L DE+ QR L AE EA +++EEL +R
Sbjct: 2188 VEQELTTLRLQLEETDHQKNLLDEELQR--LKAEATEAARQRSQVEEELFSVRV------ 2239
Query: 908 SETEEASQLKERLEKE-----------------------KKLTSDLGRAATRLQE---LL 941
+ EE S+LK R+E E K++ + R + QE L
Sbjct: 2240 -QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2298
Query: 942 KTTQEQLAREKDTVKK-LQEQLEKAEDGSSSK 972
+ +E LA+++ +K L+E+++ ++ + K
Sbjct: 2299 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2330
Score = 120 bits (302), Expect = 5e-27
Identities = 226/1009 (22%), Positives = 419/1009 (41%), Gaps = 122/1009 (12%)
Query: 35 ETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKK--EEKPNGKIPDHDPAPNV 92
E +E ++E+ + V+ ++++++++++ + ++ E + K + A
Sbjct: 1391 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1450
Query: 93 TVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPA 152
+ + E +R + + T Q + + A +E A + +++ E+ +V+
Sbjct: 1451 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1510
Query: 153 VSSVVNSIQVLTSKA-AILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADG 211
+ L S+ A E A ++ R + +EA + + ++
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQV 1569
Query: 212 PLYLPYKTLVSTVGSM--VFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQL 269
L ++ + + S F E AQ L L E+ + +A ++ A +R
Sbjct: 1570 ALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1628
Query: 270 EEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
EE E+ L Q A A +LR +E+A +K+ A A EA+ +K+ RE AR
Sbjct: 1629 EEAERELERWQLKANEAL-RLRLQAEEVAQQKSLAQA-EAEKQKEEAERE-------ARR 1679
Query: 330 QASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNA 389
+ E ++L + Q QL G Q +QE LR Q Q + +
Sbjct: 1680 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE- 1738
Query: 390 ELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQK 449
ELA+L++E + +++ E + + + + L A A E++ ++ EA
Sbjct: 1739 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1798
Query: 450 RLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQ 509
R E++ E A LRA AE+A+ +Q+Q+AE + Q +EAE R E+L+ +
Sbjct: 1799 RFRELAEEA-------ARLRALAEEAK-RQRQLAEEDAARQRAEAE-RVLAEKLAAIGEA 1849
Query: 510 ----------LQEARAENSQLTERIRSIEAL----LEAGQARDAQDVQ--------ASQA 547
L+E AEN +L R+ EA LE A+ D++ AS +
Sbjct: 1850 TRLKTEAEIALKEKEAENERL-RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1908
Query: 548 EADQQQTRLKELESQVSGLEKEAIELREAVEQQ------------KVKNN---DLREKNW 592
E ++Q+ +++ Q +E+E + L+ + E+ ++++N LR K
Sbjct: 1909 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1968
Query: 593 KAMEA-----LATAEQA----CKEKLHSLTQAKEESEKQ--LCLIEAQTMEALLALLPEL 641
+EA LA E+ +E++ A+EE+ +Q L E + ++A + L
Sbjct: 1969 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2028
Query: 642 SVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSI 701
A+Q LQ +E L+ AE + + ++ +E Q TLQ E +S+
Sbjct: 2029 RERAEQESARQLQLAQEAAQKRLQ-----AEEKAHAFAVQQKEQELQQTLQQE----QSV 2079
Query: 702 LAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQV 761
L + G +++ EE E+ A+V A E Q R E E+LK E Q
Sbjct: 2080 LDQLRGEAEAARRAAEEAEE---ARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQA 2131
Query: 762 REHTSHLEAELEKHMAAASAECQNYAK-EVAGLRQLLLESQSQLDAAKSEAQKQSDELAL 820
R + +A EK A E A+ E A LRQ + ++++ K A++ + A
Sbjct: 2132 R---AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAEQTLRQKAQ 2187
Query: 821 VRQQLSEMKSHVEDGDIAG------APASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQ 874
V Q+L+ ++ +E+ D EA A + Q++ +L +E+
Sbjct: 2188 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2247
Query: 875 RQKLTAE-----FEEAQTSACRLQEELEKLRT--------------AGPLESSETEEASQ 915
+ ++ AE + + LQEE EK++ A L E+ +Q
Sbjct: 2248 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2307
Query: 916 LKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEK 964
+ EK K + ATRL+ + Q+Q ++ ++LQE E+
Sbjct: 2308 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2356
Score = 113 bits (283), Expect = 8e-25
Identities = 192/851 (22%), Positives = 366/851 (43%), Gaps = 106/851 (12%)
Query: 183 AQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLV---STVGSMVFNE-GEAQRLI 238
AQ+ A E A K S K + +A P + + + VG + GE +
Sbjct: 1119 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1178
Query: 239 EILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMA 298
E E+ + + W + D + +R+LE+ + L +E A + L++ +
Sbjct: 1179 ERWRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1235
Query: 299 AEKAKAAAGEAKVKKQLVAREQEITAVQAR------MQASYREHVKEVQQLQGKIRTLQE 352
+A A V++QL + + ++ Q ++++ ++ + ++ T +
Sbjct: 1236 QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1295
Query: 353 QLEN--GPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSE 410
QLE P + S++++ ++ T +EL L + K E + + E
Sbjct: 1296 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHY------SELTTLTSQYIKFISETLRRME 1349
Query: 411 -----AVRQDEQQRKALEAKAAAFEKQVLQLQASH--------RESEEALQKRLDEVSRE 457
A +Q ++R+ L AA EKQ QL +H RE++E Q+ +EV R
Sbjct: 1350 EEERLAEQQRAEERERLAEVEAALEKQ-RQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1408
Query: 458 LCHTQSSHASLRADAEKAQE-QQQQMAELHSKLQSSEAEVRSKC---EEL---------- 503
+ R+ E+ Q+ +Q AE+ +K + +EA RS+ EE+
Sbjct: 1409 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1468
Query: 504 ----SGLHGQLQ--EARAENSQLTERIRSIEALL-------EAGQARDAQDVQASQAEAD 550
G G+LQ ARAE ++ +R EA E+ + R A+ AS+ +A+
Sbjct: 1469 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1528
Query: 551 QQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLH 610
+ R E + + LE+ ++ EA +++++ ++ E+ + AL TA+++ + +L
Sbjct: 1529 AEAAR--EKQRALQALEELRLQAEEA--ERRLRQAEV-ERARQVQVALETAQRSAEAELQ 1583
Query: 611 SLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAP 670
S + E QL + A+ L E AQQ + +E+ L+
Sbjct: 1584 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE--AERAREEAERELERWQLK 1641
Query: 671 AEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAA 730
A + L + E + +S QAE ++ + E R+ ++ + EEQ R + A
Sbjct: 1642 ANEALRLRLQAEEVAQQKSLAQAEAEK------QKEEAEREARRRGKAEEQAVRQR-ELA 1694
Query: 731 EEELQKSRVTVK-------HLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAEC 783
E+EL+K R + E+ + +L+ E E +Q R+ A L++ AAA+ +
Sbjct: 1695 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1754
Query: 784 QNYAKEVAGLR---QLLLESQSQLD---AAKSEAQKQSDELALVR-QQLSEMKSHVEDGD 836
Q E+A +R ++LL S+++ + + SE KQ E R ++L+E + +
Sbjct: 1755 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR--- 1811
Query: 837 IAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEEL 896
A A + + AE+D + + + E +L ++ + T EA+ + + E
Sbjct: 1812 -ALAEEAKRQRQLAEEDAARQRAE---AERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1867
Query: 897 EKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVK 956
E+LR L E + +L+E+ + K +D+ RL +L K + +L R+K V+
Sbjct: 1868 ERLRR---LAEDEAFQRRRLEEQAAQHK---ADI---EERLAQLRKASDSELERQKGLVE 1918
Query: 957 KLQEQLEKAED 967
Q + E+
Sbjct: 1919 DTLRQRRQVEE 1929
Score = 111 bits (278), Expect = 3e-24
Identities = 176/765 (23%), Positives = 322/765 (42%), Gaps = 117/765 (15%)
Query: 266 KRQLEEK-EKLLATEQEDAAVAKSKLRELNKEMA----AEKAKAAAGEAKVKKQLVAREQ 320
+R+ EE+ +K LA E+E A K+ L E+ + A A + + A + ++ +A+E
Sbjct: 1987 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE- 2045
Query: 321 EITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQAT 380
A Q R+QA + H VQQ K + LQ+ L QQE S+L +A
Sbjct: 2046 ---AAQKRLQAEEKAHAFAVQQ---KEQELQQTL-----------QQEQSVLDQLRGEAE 2088
Query: 381 SQVESKQNAELAKLRQELSKV-SKELVEKSEAVRQ--DEQQRKALEAKAAA--FEKQVLQ 435
+ + + AE A+++ E S+ VE++E ++Q +EQ + +A+AAA K+ Q
Sbjct: 2089 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2148
Query: 436 LQASHRESEEALQKRLDEVSREL-CHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEA 494
A ++E+A ++ E+ H + + +LR +KAQ +Q+ + L +L+ ++
Sbjct: 2149 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR---QKAQVEQE-LTTLRLQLEETDH 2204
Query: 495 EVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLE--------------AGQARDAQ 540
+ EEL L + EA + SQ+ E + S+ +E A RD
Sbjct: 2205 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2264
Query: 541 DVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAM----- 595
+ Q E ++ ++ E +++S +EA LR+ E+ + L EK K
Sbjct: 2265 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2324
Query: 596 ---------EALATAEQACKEKLHSLTQAKEESEKQLC--------------------LI 626
E L ++ +E+ L + KE+ +QL
Sbjct: 2325 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2384
Query: 627 EAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEE 686
EA+ ++ +A + A+++ + + +E G L + A E + L L E +
Sbjct: 2385 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTL-EIQR 2442
Query: 687 TQSTLQAECDQYRSILAETEGMLRDLQKSV-------EEEEQVWRAKVGAAEEELQKSRV 739
QS AE + R +AE E LQ+ EE + V + ++ + LQ+S +
Sbjct: 2443 QQSDHDAE--RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2500
Query: 740 TVK----HLEEIVEKLKGELES--------SDQVREHTSHLEAELEKHMAAASAECQNYA 787
+ K E +E+ K +LE + Q+RE + ++E+ A +
Sbjct: 2501 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2560
Query: 788 KEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEA 847
+ + + Q +L + + ++Q + LA Q+L E +E+ A A A S E
Sbjct: 2561 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA-ALAHSEEV 2619
Query: 848 PPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLES 907
++ KT +A+ + + + + SA RLQE AG L +
Sbjct: 2620 TASQ--VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE-------AGILSA 2670
Query: 908 SETEEASQ---LKERLEKEKKLTSDLGRAATRLQELLKTTQEQLA 949
E + +Q + L + + + L ++ LLK T E+L+
Sbjct: 2671 EELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLS 2715
Score = 91.3 bits (225), Expect = 4e-18
Identities = 142/624 (22%), Positives = 248/624 (39%), Gaps = 69/624 (11%)
Query: 364 RLQQENSILRDALNQATSQVESKQNAE-LAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
RL + R+ + Q +++ E L K LS +++++ E R L
Sbjct: 1012 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1071
Query: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM 482
E E QV L A + E +L +S + TQ + LRA E+ +E Q
Sbjct: 1072 ELTLGKLE-QVRSLSAIYLE-------KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1123
Query: 483 AEL------HSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQA 536
A L + L+ A+ ++ L +L+ A+ +L +R + +E +
Sbjct: 1124 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1183
Query: 537 RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAME 596
R AQ ++ QA Q R +ELE L ++ RE+ + D R + +
Sbjct: 1184 RVAQLLERWQAVLAQTDVRQRELEQ----LGRQLRYYRESADPLGAWLQDARRRQEQIQA 1239
Query: 597 ALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDL 656
QA +E+L EE E+ +E Q+ +++ +
Sbjct: 1240 MPLADSQAVREQLRQEQALLEEIERHGEKVEE----------------CQRFAKQYINAI 1283
Query: 657 KEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSV 716
K+ L+ + A EP + A K + ++S +Q D R+ +E + K +
Sbjct: 1284 KDYELQLVTYK-AQLEPVASPAKKPKVQSGSESVIQEYVD-LRTHYSELTTLTSQYIKFI 1341
Query: 717 EEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHM 776
E T++ +EE E+ E + +++ RE + +EA LEK
Sbjct: 1342 SE---------------------TLRRMEE--EERLAEQQRAEE-RERLAEVEAALEKQR 1377
Query: 777 AAASAECQNYA---KEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVE 833
A A Q A +E L+Q + E + + A +AQ+Q + QQL +
Sbjct: 1378 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1437
Query: 834 DGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQ 893
A A+ E++ ++ QLE TE + + Q L A EEA+ + Q
Sbjct: 1438 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1497
Query: 894 EELEKLRTAGPLESSETEEAS-QLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAR-- 950
EE E+LR ES +A +L R++ E + + RA L+EL +E R
Sbjct: 1498 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1557
Query: 951 --EKDTVKKLQEQLEKAEDGSSSK 972
E + +++Q LE A+ + ++
Sbjct: 1558 QAEVERARQVQVALETAQRSAEAE 1581
Score = 76.3 bits (186), Expect = 1e-13
Identities = 119/582 (20%), Positives = 255/582 (43%), Gaps = 45/582 (7%)
Query: 143 EKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSK 202
++K +++ + + + L +A A +E V EA + ++ K
Sbjct: 2063 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2122
Query: 203 KKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDT-----WHKATQ 257
+ A + + E E + +E+A + Q K +
Sbjct: 2123 QSAEEQAQA------RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2176
Query: 258 KGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVA 317
+ K Q+E++ L + E+ K+ L E + + AE +AA ++V+++L +
Sbjct: 2177 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2236
Query: 318 ---REQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRD 374
+ +E++ ++AR++A R + ++ R LQE+ E ++ ++ +E + L
Sbjct: 2237 VRVQMEELSKLKARIEAENRALI--LRDKDNTQRFLQEEAE-----KMKQVAEEAARLSV 2289
Query: 375 ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVL 434
A +A +Q AE L Q+ + K L EK +AV+ E R EA+ +K++
Sbjct: 2290 AAQEAA---RLRQLAE-EDLAQQRALAEKMLKEKMQAVQ--EATRLKAEAELLQQQKELA 2343
Query: 435 QLQASH-RESEEALQKRLDEVSRELCHT----QSSHASLRADAEKAQEQQQQMAELHSKL 489
Q QA +E +E + ++L E ++ T + + A+AE+ + + +M+ ++
Sbjct: 2344 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2403
Query: 490 QSSEAEVRSKCEELSGLHGQLQEARAENSQL--TERIRSIEALLEAGQARDAQDVQASQA 547
+ R + EE+ + + A E L T I+ ++ +A + R+A +
Sbjct: 2404 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2463
Query: 548 EADQQQTRLKELESQ--VSGLEKEAIELREAVEQQKVKNND-LREKNWKAMEALATAEQA 604
E QQ+ +L +L+S+ + +++ ++ +A++Q + D L ++ + A EQ
Sbjct: 2464 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2523
Query: 605 CKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLL 664
++++ Q +EE ++Q +E Q + L+A + E A++ E + ++ K L
Sbjct: 2524 FQDEVAKAQQLREEQQRQQQQME-QERQRLVASMEE----ARRRQHEAEEGVRRKQEELQ 2578
Query: 665 KHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETE 706
+ + LA E + + LQ +Q+R+ LA +E
Sbjct: 2579 QLEQQRRQQEELLA---EENQRLREQLQLLEEQHRAALAHSE 2617
Score = 52.4 bits (124), Expect = 2e-06
Identities = 169/750 (22%), Positives = 280/750 (37%), Gaps = 152/750 (20%)
Query: 295 KEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKI------- 347
KEM +A +K Q + E + A Q ++ Y H +V++ GK+
Sbjct: 329 KEMELPAKEADKNRSKGIYQSL--EGAVQAGQLKVPPGY--HPLDVEKEWGKLHVAILER 384
Query: 348 -RTLQEQLENGPNTQ--LARLQQENSILRDALNQATSQVESKQNAELA-KLRQELSKVSK 403
+ L+ + E Q + +LQ E + + LNQA + ++S A K+ Q +V +
Sbjct: 385 EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVER 444
Query: 404 ELVEKSEAVR---------------QDEQQRKAL----EAKAAAFEKQVLQLQAS-HRES 443
+L + +R Q EQ + + E A + L+L+A +
Sbjct: 445 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 504
Query: 444 EEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM--AELHSKLQSSEAEVRSKCE 501
+ Q L V R S+ L+ +E Q ++ AE L S EA++ S
Sbjct: 505 TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH-- 562
Query: 502 ELSGLHGQLQEARAENSQLTERIRSIEALLEA---GQARDAQ---DVQASQAEADQQQTR 555
GLH ++E RA+ ER RS E L G RD D+Q ++ + + R
Sbjct: 563 --RGLHQSIEEFRAK----IERARSDEGQLSPATRGAYRDCLGRLDLQYAKL-LNSSKAR 615
Query: 556 LKELESQ---VSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSL 612
L+ LES V+ KE + L E E++ D ++N T A KE +L
Sbjct: 616 LRSLESLHSFVAAATKELMWLNEKEEEEV--GFDWSDRN--------TNMTAKKESYSAL 665
Query: 613 TQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLK--HPPAP 670
+ E EK++ ++L+ G LL+ HP P
Sbjct: 666 MRELELKEKKI------------------------------KELQNAGDRLLREDHPARP 695
Query: 671 AEPSSDLASKLREAEETQSTLQAECD--------QYRSILAETEGMLRDLQKSVEEEEQV 722
S A + + + Q E Q+ S + E EG L+ LQ+++ +
Sbjct: 696 TVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSC 755
Query: 723 WRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAE 782
R+ TV LE++++ + E E Q+ E+ HL ++ A +
Sbjct: 756 DRS-------------ATVTRLEDLLQDAQDEKE---QLNEYKGHLSGLAKRAKAVVQLK 799
Query: 783 CQNYAKEVAGLRQLLLESQSQLDAAKSEAQ-KQSDELALV-RQQLSEMKSHVEDGDIAGA 840
++ A + G LL + D + E + DE LV Q S K G A
Sbjct: 800 PRHPAHPMRGRLPLL----AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAV 855
Query: 841 PASSPEAPPAEQDP----------------------VQLKTQLEWTEAILEDEQTQRQKL 878
P+ PP Q+ V +K+ L W +++ D Q R
Sbjct: 856 PSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW-QSLRRDVQLIRSWS 914
Query: 879 TAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQ 938
A F + R +L L S+ ++RL E++ S LQ
Sbjct: 915 LATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQ 974
Query: 939 ELLKTTQEQLAREK--DTVKKLQEQLEKAE 966
L + QE+ ++ +K ++ QLE E
Sbjct: 975 SLEQGAQEESRCQRCISELKDIRLQLEACE 1004
Score = 37.7 bits (86), Expect = 0.053
Identities = 109/534 (20%), Positives = 200/534 (37%), Gaps = 48/534 (8%)
Query: 39 EEALANQR---KEMAKTHHQKVEK------------KKKEKTVEKKGKTKKKEEKPNGKI 83
EE LA QR ++M K Q V++ ++KE E+ + ++ +E+ ++
Sbjct: 2302 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2361
Query: 84 PDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKE 143
+ T+ E R + ++ + + VA ++ A +E K ++
Sbjct: 2362 AEETQGFQRTL---EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2418
Query: 144 KKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKK 203
+K+ + E A V +Q L + + + R E K + AK +
Sbjct: 2419 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2478
Query: 204 KGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGI---IQDTWHKATQKGD 260
+ L + L + S + + +R IE EKA + QD KA Q +
Sbjct: 2479 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE--QEKAKLEQLFQDEVAKAQQLRE 2536
Query: 261 PVAILKRQLEEKEKLLATEQEDAA----VAKSKLRELNKEM-AAEKAKAAAGEAKVKKQL 315
++Q+E++ + L E+A A+ +R +E+ E+ + E ++
Sbjct: 2537 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2596
Query: 316 VAREQ-EITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRD 374
REQ ++ Q R ++ E V Q K +GP + + + R
Sbjct: 2597 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRK 2656
Query: 375 ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVL 434
Q + EL +L Q + V + + + E VR Q R ++ + L
Sbjct: 2657 VSAQRLQEAGILSAEELQRLAQGHTTVDE--LARREDVRHYLQGRSSIAGLLLKATNEKL 2714
Query: 435 QLQASHRESEEALQKRLDEVSRELCHTQSSHAS---------LRADAEKAQEQQQQMAEL 485
+ A ALQ++L L ++ AS R +A ++ EL
Sbjct: 2715 SVYA-------ALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPEL 2767
Query: 486 HSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTER-IRSIEALLEAGQARD 538
H KL S+E V + +G L +A + + E IR +EA + G D
Sbjct: 2768 HHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVID 2821
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 132 bits (333), Expect = 1e-30
Identities = 221/1001 (22%), Positives = 413/1001 (41%), Gaps = 150/1001 (14%)
Query: 40 EALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREP 99
E A +++E+A+ Q++EK+++ + + ++E + +L E
Sbjct: 1680 EEQAVRQRELAE---QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736
Query: 100 VRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNS 159
R A A T + + A +A V A + LAS + +++ K + + +
Sbjct: 1737 ARLQREAAAATQKRQEL-EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1795
Query: 160 IQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKT 219
+ L +AA L +E + +A +Q A A++ K +A T
Sbjct: 1796 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA---------T 1846
Query: 220 LVSTVGSMVFNEGEAQ--RLIEILSEKAGII-----QDTWHKAT---------------- 256
+ T + E EA+ RL + ++A Q HKA
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 257 --QKG--DPVAILKRQLEEKEKLLATEQEDAAVAKSKL-----------------RELNK 295
QKG + +RQ+EE+ L E AA K++L +E +
Sbjct: 1907 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 296 EMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKI---RTLQE 352
AA + + AA E + +++ R Q+ A + + ++EV++L+ K+ R L+E
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 353 QLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAV 412
+ E QL Q+ A +A + ++ EL + Q+ V +L ++EA
Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2086
Query: 413 R----QDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDE--VSRELCHTQSSHA 466
R + E+ R E +AA +QV + + + +EE Q R + +L A
Sbjct: 2087 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 467 SLRADAEKAQEQQQQMA--ELHSKLQSSEAEVRSKCE---ELSGLHGQLQEARAENSQLT 521
+ RA AE+A +Q+Q A E+ + +E +R K + EL+ L QL+E + + L
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 522 ERIRSIEALLEAGQA-RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQ 580
E ++ ++A EA +A R V+ Q L +L++++ E A+ LR+ Q
Sbjct: 2207 EELQRLKA--EATEAARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQ 2263
Query: 581 KVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPE 640
+ + EK + E A A +E A+E+ +Q L E E + A+
Sbjct: 2264 RFLQEEA-EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322
Query: 641 LSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQS---TLQAECDQ 697
+ A+ + ++L ++ L+ E +A +L AEETQ TL+AE +
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQ------EDKEQMAQQL--AEETQGFQRTLEAERQR 2374
Query: 698 YRSILAETEGM------LRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKL 751
+ AE E + + Q EE+ Q +R + E+L ++ + + +V+ L
Sbjct: 2375 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2434
Query: 752 KGELESSD----QVREHTSHLEAELEK-HMAAASAECQNYAKEVAGLRQLLLESQSQLDA 806
+ + + SD ++RE + LE E EK A + ++ + QLL E+Q+ +
Sbjct: 2435 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2494
Query: 807 AKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEA 866
SE + Q+ ++++ +D ++A A QL+ + + +
Sbjct: 2495 FLSEKDSLLQRERFIEQEKAKLEQLFQD-EVAKAQ--------------QLREEQQRQQQ 2539
Query: 867 ILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKL 926
+E E RQ+L A EEA+ +E + + + EE QL+++
Sbjct: 2540 QMEQE---RQRLVASMEEARRRQHEAEEGVRR----------KQEELQQLEQQ------- 2579
Query: 927 TSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAED 967
+ QE+L E++ ++L+EQL+ E+
Sbjct: 2580 ---------------RRQQEELLAEEN--QRLREQLQLLEE 2603
Score = 131 bits (329), Expect = 4e-30
Identities = 191/766 (24%), Positives = 334/766 (43%), Gaps = 108/766 (14%)
Query: 267 RQLEEKEKLL----ATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEI 322
R++EE+E+L A E+E A ++ L E +++A A+A A + K+L R QE
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAAL-EKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400
Query: 323 T------AVQARMQA-SYREHVKEVQQL-QGKIRTLQEQLENGPNTQLARLQQENSILRD 374
AV A+ Q S +E +++++Q + +I+ Q E ++L R+++E ++R
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVVRL 1459
Query: 375 ALNQATSQVESKQNAELAKLR---QELSKVSKELVEKSEAVR---QDEQQRKA------- 421
L +AT + EL LR +E ++ E++E +R QDE QRK
Sbjct: 1460 QL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518
Query: 422 ----LEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHT---------QSSHASL 468
EA+AA +++ LQ R E ++RL + E +S+ A L
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1578
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTER--IRS 526
++ E+ Q+ + + A++R + E + + + AR E + ER +++
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638
Query: 527 IEALLEAGQARD-AQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNN 585
EAL QA + AQ +QAEA++Q+ + + E++A+ RE EQ+ K
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 586 DLREKNWKAMEALATAEQ--ACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSV 643
L E TA+Q A +++L L E+ E+Q L+E + LA L +
Sbjct: 1699 QLAE---------GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAA 1744
Query: 644 LAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQST-------LQAECD 696
A Q E +L + AE LASK R EE++ST L+AE
Sbjct: 1745 AATQKRQELEAELAK----------VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794
Query: 697 QYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELE 756
++R LAE LR L + + + Q+ A+ AA + + RV + L I E + + E
Sbjct: 1795 RFRE-LAEEAARLRALAEEAKRQRQL--AEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851
Query: 757 SSDQVREHTSHLEAELEKHMAAASAEC-----------QNYAKEVAGLRQLLLESQSQLD 805
+ ++E EAE E+ A E Q+ A L QL S S+L+
Sbjct: 1852 AEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1907
Query: 806 AAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSP--EAPPAEQDPVQLKTQLEW 863
K + + V +++ +K+ E A +D ++ K Q E
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967
Query: 864 TEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKE 923
A + ++ E EE + +EE + R A EE +LK ++E+
Sbjct: 1968 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA------LEEVERLKAKVEEA 2021
Query: 924 KKLTSDLGR-AATRLQELLKTTQEQLAREKD----TVKKLQEQLEK 964
++L + +A +LQ + Q++L E+ V++ +++L++
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2067
Score = 125 bits (313), Expect = 3e-28
Identities = 182/812 (22%), Positives = 335/812 (41%), Gaps = 111/812 (13%)
Query: 231 EGEAQRLIEILSEKA--GIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKS 288
E E R +++ E A + K + A L+R L+E+ +A +E+A
Sbjct: 1556 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE---- 1611
Query: 289 KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIR 348
R ++ AE+A+ A + QL A E A++ R+QA K + Q +
Sbjct: 1612 --RRAQQQAEAERAREEAERELERWQLKANE----ALRLRLQAEEVAQQKSLAQAEA--- 1662
Query: 349 TLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEK 408
++Q E R + E +R A ++E ++ +Q L+ +EL+
Sbjct: 1663 --EKQKEEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLAEGTAQQRLA-AEQELIRL 1718
Query: 409 SEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASL 468
Q EQQR+ LE + A +++ +E E L K E+ L +
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1778
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERI--RS 526
R+ +EK++++ + A +L A +R+ EE +E A ER+
Sbjct: 1779 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1838
Query: 527 IEALLEAGQARDAQDVQASQAEADQ------------QQTRLKELESQ-VSGLEKEAIEL 573
+ A+ EA + + ++ + EA+ Q+ RL+E +Q + +E+ +L
Sbjct: 1839 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1898
Query: 574 REAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEA 633
R+A + + + L E + + A K K E E +L I + +
Sbjct: 1899 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1958
Query: 634 LLAL-LPELSVLAQ-QNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTL 691
L + EL Q Q E + +E + K A E + + L E E ++ +
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018
Query: 692 Q--------AECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKH 743
+ AE + R + E QK ++ EE+ V E+ELQ+ T++
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEA----AQKRLQAEEKAHAFAVQQKEQELQQ---TLQQ 2071
Query: 744 LEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAA------------SAECQNYAKEVA 791
+ ++++L+GE E++ + E + E+ A + SAE Q A+ A
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2131
Query: 792 GLRQLLLESQSQLDAAKSEAQKQSDELALVRQQL--SEMKSHVEDGDIAGAPASSPEAPP 849
L +++ +AA+ + Q+++ AL ++Q +EM+ H + A + +
Sbjct: 2132 QAAAEKLRKEAEQEAAR---RAQAEQAALRQKQAADAEMEKHKK-----FAEQTLRQKAQ 2183
Query: 850 AEQDPVQLKTQLEWT--EAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLES 907
EQ+ L+ QLE T + L DE+ QR L AE EA +++EEL +R
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQR--LKAEATEAARQRSQVEEELFSVRV------ 2235
Query: 908 SETEEASQLKERLEKE-----------------------KKLTSDLGRAATRLQE---LL 941
+ EE S+LK R+E E K++ + R + QE L
Sbjct: 2236 -QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294
Query: 942 KTTQEQLAREKDTVKK-LQEQLEKAEDGSSSK 972
+ +E LA+++ +K L+E+++ ++ + K
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2326
Score = 120 bits (302), Expect = 5e-27
Identities = 226/1009 (22%), Positives = 419/1009 (41%), Gaps = 122/1009 (12%)
Query: 35 ETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKK--EEKPNGKIPDHDPAPNV 92
E +E ++E+ + V+ ++++++++++ + ++ E + K + A
Sbjct: 1387 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1446
Query: 93 TVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPA 152
+ + E +R + + T Q + + A +E A + +++ E+ +V+
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506
Query: 153 VSSVVNSIQVLTSKA-AILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADG 211
+ L S+ A E A ++ R + +EA + + ++
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQV 1565
Query: 212 PLYLPYKTLVSTVGSM--VFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQL 269
L ++ + + S F E AQ L L E+ + +A ++ A +R
Sbjct: 1566 ALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624
Query: 270 EEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
EE E+ L Q A A +LR +E+A +K+ A A EA+ +K+ RE AR
Sbjct: 1625 EEAERELERWQLKANEAL-RLRLQAEEVAQQKSLAQA-EAEKQKEEAERE-------ARR 1675
Query: 330 QASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNA 389
+ E ++L + Q QL G Q +QE LR Q Q + +
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE- 1734
Query: 390 ELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQK 449
ELA+L++E + +++ E + + + + L A A E++ ++ EA
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794
Query: 450 RLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQ 509
R E++ E A LRA AE+A+ +Q+Q+AE + Q +EAE R E+L+ +
Sbjct: 1795 RFRELAEEA-------ARLRALAEEAK-RQRQLAEEDAARQRAEAE-RVLAEKLAAIGEA 1845
Query: 510 ----------LQEARAENSQLTERIRSIEAL----LEAGQARDAQDVQ--------ASQA 547
L+E AEN +L R+ EA LE A+ D++ AS +
Sbjct: 1846 TRLKTEAEIALKEKEAENERL-RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904
Query: 548 EADQQQTRLKELESQVSGLEKEAIELREAVEQQ------------KVKNN---DLREKNW 592
E ++Q+ +++ Q +E+E + L+ + E+ ++++N LR K
Sbjct: 1905 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1964
Query: 593 KAMEA-----LATAEQA----CKEKLHSLTQAKEESEKQ--LCLIEAQTMEALLALLPEL 641
+EA LA E+ +E++ A+EE+ +Q L E + ++A + L
Sbjct: 1965 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2024
Query: 642 SVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSI 701
A+Q LQ +E L+ AE + + ++ +E Q TLQ E +S+
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQ-----AEEKAHAFAVQQKEQELQQTLQQE----QSV 2075
Query: 702 LAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQV 761
L + G +++ EE E+ A+V A E Q R E E+LK E Q
Sbjct: 2076 LDQLRGEAEAARRAAEEAEE---ARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQA 2127
Query: 762 REHTSHLEAELEKHMAAASAECQNYAK-EVAGLRQLLLESQSQLDAAKSEAQKQSDELAL 820
R + +A EK A E A+ E A LRQ + ++++ K A++ + A
Sbjct: 2128 R---AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAEQTLRQKAQ 2183
Query: 821 VRQQLSEMKSHVEDGDIAG------APASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQ 874
V Q+L+ ++ +E+ D EA A + Q++ +L +E+
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2243
Query: 875 RQKLTAE-----FEEAQTSACRLQEELEKLRT--------------AGPLESSETEEASQ 915
+ ++ AE + + LQEE EK++ A L E+ +Q
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303
Query: 916 LKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEK 964
+ EK K + ATRL+ + Q+Q ++ ++LQE E+
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Score = 113 bits (283), Expect = 8e-25
Identities = 192/851 (22%), Positives = 366/851 (43%), Gaps = 106/851 (12%)
Query: 183 AQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLV---STVGSMVFNE-GEAQRLI 238
AQ+ A E A K S K + +A P + + + VG + GE +
Sbjct: 1115 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1174
Query: 239 EILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMA 298
E E+ + + W + D + +R+LE+ + L +E A + L++ +
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1231
Query: 299 AEKAKAAAGEAKVKKQLVAREQEITAVQAR------MQASYREHVKEVQQLQGKIRTLQE 352
+A A V++QL + + ++ Q ++++ ++ + ++ T +
Sbjct: 1232 QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1291
Query: 353 QLEN--GPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSE 410
QLE P + S++++ ++ T +EL L + K E + + E
Sbjct: 1292 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHY------SELTTLTSQYIKFISETLRRME 1345
Query: 411 -----AVRQDEQQRKALEAKAAAFEKQVLQLQASH--------RESEEALQKRLDEVSRE 457
A +Q ++R+ L AA EKQ QL +H RE++E Q+ +EV R
Sbjct: 1346 EEERLAEQQRAEERERLAEVEAALEKQ-RQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 458 LCHTQSSHASLRADAEKAQE-QQQQMAELHSKLQSSEAEVRSKC---EEL---------- 503
+ R+ E+ Q+ +Q AE+ +K + +EA RS+ EE+
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464
Query: 504 ----SGLHGQLQ--EARAENSQLTERIRSIEALL-------EAGQARDAQDVQASQAEAD 550
G G+LQ ARAE ++ +R EA E+ + R A+ AS+ +A+
Sbjct: 1465 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524
Query: 551 QQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLH 610
+ R E + + LE+ ++ EA +++++ ++ E+ + AL TA+++ + +L
Sbjct: 1525 AEAAR--EKQRALQALEELRLQAEEA--ERRLRQAEV-ERARQVQVALETAQRSAEAELQ 1579
Query: 611 SLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAP 670
S + E QL + A+ L E AQQ + +E+ L+
Sbjct: 1580 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE--AERAREEAERELERWQLK 1637
Query: 671 AEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAA 730
A + L + E + +S QAE ++ + E R+ ++ + EEQ R + A
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEK------QKEEAEREARRRGKAEEQAVRQR-ELA 1690
Query: 731 EEELQKSRVTVK-------HLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAEC 783
E+EL+K R + E+ + +L+ E E +Q R+ A L++ AAA+ +
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750
Query: 784 QNYAKEVAGLR---QLLLESQSQLD---AAKSEAQKQSDELALVR-QQLSEMKSHVEDGD 836
Q E+A +R ++LL S+++ + + SE KQ E R ++L+E + +
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR--- 1807
Query: 837 IAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEEL 896
A A + + AE+D + + + E +L ++ + T EA+ + + E
Sbjct: 1808 -ALAEEAKRQRQLAEEDAARQRAE---AERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 897 EKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVK 956
E+LR L E + +L+E+ + K +D+ RL +L K + +L R+K V+
Sbjct: 1864 ERLRR---LAEDEAFQRRRLEEQAAQHK---ADI---EERLAQLRKASDSELERQKGLVE 1914
Query: 957 KLQEQLEKAED 967
Q + E+
Sbjct: 1915 DTLRQRRQVEE 1925
Score = 111 bits (278), Expect = 3e-24
Identities = 176/765 (23%), Positives = 322/765 (42%), Gaps = 117/765 (15%)
Query: 266 KRQLEEK-EKLLATEQEDAAVAKSKLRELNKEMA----AEKAKAAAGEAKVKKQLVAREQ 320
+R+ EE+ +K LA E+E A K+ L E+ + A A + + A + ++ +A+E
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE- 2041
Query: 321 EITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQAT 380
A Q R+QA + H VQQ K + LQ+ L QQE S+L +A
Sbjct: 2042 ---AAQKRLQAEEKAHAFAVQQ---KEQELQQTL-----------QQEQSVLDQLRGEAE 2084
Query: 381 SQVESKQNAELAKLRQELSKV-SKELVEKSEAVRQ--DEQQRKALEAKAAA--FEKQVLQ 435
+ + + AE A+++ E S+ VE++E ++Q +EQ + +A+AAA K+ Q
Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144
Query: 436 LQASHRESEEALQKRLDEVSREL-CHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEA 494
A ++E+A ++ E+ H + + +LR +KAQ +Q+ + L +L+ ++
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR---QKAQVEQE-LTTLRLQLEETDH 2200
Query: 495 EVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLE--------------AGQARDAQ 540
+ EEL L + EA + SQ+ E + S+ +E A RD
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2260
Query: 541 DVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAM----- 595
+ Q E ++ ++ E +++S +EA LR+ E+ + L EK K
Sbjct: 2261 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320
Query: 596 ---------EALATAEQACKEKLHSLTQAKEESEKQLC--------------------LI 626
E L ++ +E+ L + KE+ +QL
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 627 EAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEE 686
EA+ ++ +A + A+++ + + +E G L + A E + L L E +
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTL-EIQR 2438
Query: 687 TQSTLQAECDQYRSILAETEGMLRDLQKSV-------EEEEQVWRAKVGAAEEELQKSRV 739
QS AE + R +AE E LQ+ EE + V + ++ + LQ+S +
Sbjct: 2439 QQSDHDAE--RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 740 TVK----HLEEIVEKLKGELES--------SDQVREHTSHLEAELEKHMAAASAECQNYA 787
+ K E +E+ K +LE + Q+RE + ++E+ A +
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556
Query: 788 KEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEA 847
+ + + Q +L + + ++Q + LA Q+L E +E+ A A A S E
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA-ALAHSEEV 2615
Query: 848 PPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLES 907
++ KT +A+ + + + + SA RLQE AG L +
Sbjct: 2616 TASQ--VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE-------AGILSA 2666
Query: 908 SETEEASQ---LKERLEKEKKLTSDLGRAATRLQELLKTTQEQLA 949
E + +Q + L + + + L ++ LLK T E+L+
Sbjct: 2667 EELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLS 2711
Score = 91.3 bits (225), Expect = 4e-18
Identities = 142/624 (22%), Positives = 248/624 (39%), Gaps = 69/624 (11%)
Query: 364 RLQQENSILRDALNQATSQVESKQNAE-LAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
RL + R+ + Q +++ E L K LS +++++ E R L
Sbjct: 1008 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1067
Query: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM 482
E E QV L A + E +L +S + TQ + LRA E+ +E Q
Sbjct: 1068 ELTLGKLE-QVRSLSAIYLE-------KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1119
Query: 483 AEL------HSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQA 536
A L + L+ A+ ++ L +L+ A+ +L +R + +E +
Sbjct: 1120 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1179
Query: 537 RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAME 596
R AQ ++ QA Q R +ELE L ++ RE+ + D R + +
Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRELEQ----LGRQLRYYRESADPLGAWLQDARRRQEQIQA 1235
Query: 597 ALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDL 656
QA +E+L EE E+ +E Q+ +++ +
Sbjct: 1236 MPLADSQAVREQLRQEQALLEEIERHGEKVEE----------------CQRFAKQYINAI 1279
Query: 657 KEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSV 716
K+ L+ + A EP + A K + ++S +Q D R+ +E + K +
Sbjct: 1280 KDYELQLVTYK-AQLEPVASPAKKPKVQSGSESVIQEYVD-LRTHYSELTTLTSQYIKFI 1337
Query: 717 EEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHM 776
E T++ +EE E+ E + +++ RE + +EA LEK
Sbjct: 1338 SE---------------------TLRRMEE--EERLAEQQRAEE-RERLAEVEAALEKQR 1373
Query: 777 AAASAECQNYA---KEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVE 833
A A Q A +E L+Q + E + + A +AQ+Q + QQL +
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1433
Query: 834 DGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQ 893
A A+ E++ ++ QLE TE + + Q L A EEA+ + Q
Sbjct: 1434 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1493
Query: 894 EELEKLRTAGPLESSETEEAS-QLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAR-- 950
EE E+LR ES +A +L R++ E + + RA L+EL +E R
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1553
Query: 951 --EKDTVKKLQEQLEKAEDGSSSK 972
E + +++Q LE A+ + ++
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAE 1577
Score = 76.3 bits (186), Expect = 1e-13
Identities = 119/582 (20%), Positives = 255/582 (43%), Gaps = 45/582 (7%)
Query: 143 EKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSK 202
++K +++ + + + L +A A +E V EA + ++ K
Sbjct: 2059 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2118
Query: 203 KKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDT-----WHKATQ 257
+ A + + E E + +E+A + Q K +
Sbjct: 2119 QSAEEQAQA------RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2172
Query: 258 KGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVA 317
+ K Q+E++ L + E+ K+ L E + + AE +AA ++V+++L +
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 318 ---REQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRD 374
+ +E++ ++AR++A R + ++ R LQE+ E ++ ++ +E + L
Sbjct: 2233 VRVQMEELSKLKARIEAENRALI--LRDKDNTQRFLQEEAE-----KMKQVAEEAARLSV 2285
Query: 375 ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVL 434
A +A +Q AE L Q+ + K L EK +AV+ E R EA+ +K++
Sbjct: 2286 AAQEAA---RLRQLAE-EDLAQQRALAEKMLKEKMQAVQ--EATRLKAEAELLQQQKELA 2339
Query: 435 QLQASH-RESEEALQKRLDEVSRELCHT----QSSHASLRADAEKAQEQQQQMAELHSKL 489
Q QA +E +E + ++L E ++ T + + A+AE+ + + +M+ ++
Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2399
Query: 490 QSSEAEVRSKCEELSGLHGQLQEARAENSQL--TERIRSIEALLEAGQARDAQDVQASQA 547
+ R + EE+ + + A E L T I+ ++ +A + R+A +
Sbjct: 2400 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2459
Query: 548 EADQQQTRLKELESQ--VSGLEKEAIELREAVEQQKVKNND-LREKNWKAMEALATAEQA 604
E QQ+ +L +L+S+ + +++ ++ +A++Q + D L ++ + A EQ
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2519
Query: 605 CKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLL 664
++++ Q +EE ++Q +E Q + L+A + E A++ E + ++ K L
Sbjct: 2520 FQDEVAKAQQLREEQQRQQQQME-QERQRLVASMEE----ARRRQHEAEEGVRRKQEELQ 2574
Query: 665 KHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETE 706
+ + LA E + + LQ +Q+R+ LA +E
Sbjct: 2575 QLEQQRRQQEELLA---EENQRLREQLQLLEEQHRAALAHSE 2613
Score = 52.4 bits (124), Expect = 2e-06
Identities = 169/750 (22%), Positives = 280/750 (37%), Gaps = 152/750 (20%)
Query: 295 KEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKI------- 347
KEM +A +K Q + E + A Q ++ Y H +V++ GK+
Sbjct: 325 KEMELPAKEADKNRSKGIYQSL--EGAVQAGQLKVPPGY--HPLDVEKEWGKLHVAILER 380
Query: 348 -RTLQEQLENGPNTQ--LARLQQENSILRDALNQATSQVESKQNAELA-KLRQELSKVSK 403
+ L+ + E Q + +LQ E + + LNQA + ++S A K+ Q +V +
Sbjct: 381 EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVER 440
Query: 404 ELVEKSEAVR---------------QDEQQRKAL----EAKAAAFEKQVLQLQAS-HRES 443
+L + +R Q EQ + + E A + L+L+A +
Sbjct: 441 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 500
Query: 444 EEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM--AELHSKLQSSEAEVRSKCE 501
+ Q L V R S+ L+ +E Q ++ AE L S EA++ S
Sbjct: 501 TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH-- 558
Query: 502 ELSGLHGQLQEARAENSQLTERIRSIEALLEA---GQARDAQ---DVQASQAEADQQQTR 555
GLH ++E RA+ ER RS E L G RD D+Q ++ + + R
Sbjct: 559 --RGLHQSIEEFRAK----IERARSDEGQLSPATRGAYRDCLGRLDLQYAKL-LNSSKAR 611
Query: 556 LKELESQ---VSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSL 612
L+ LES V+ KE + L E E++ D ++N T A KE +L
Sbjct: 612 LRSLESLHSFVAAATKELMWLNEKEEEEV--GFDWSDRN--------TNMTAKKESYSAL 661
Query: 613 TQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLK--HPPAP 670
+ E EK++ ++L+ G LL+ HP P
Sbjct: 662 MRELELKEKKI------------------------------KELQNAGDRLLREDHPARP 691
Query: 671 AEPSSDLASKLREAEETQSTLQAECD--------QYRSILAETEGMLRDLQKSVEEEEQV 722
S A + + + Q E Q+ S + E EG L+ LQ+++ +
Sbjct: 692 TVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSC 751
Query: 723 WRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAE 782
R+ TV LE++++ + E E Q+ E+ HL ++ A +
Sbjct: 752 DRS-------------ATVTRLEDLLQDAQDEKE---QLNEYKGHLSGLAKRAKAVVQLK 795
Query: 783 CQNYAKEVAGLRQLLLESQSQLDAAKSEAQ-KQSDELALV-RQQLSEMKSHVEDGDIAGA 840
++ A + G LL + D + E + DE LV Q S K G A
Sbjct: 796 PRHPAHPMRGRLPLL----AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAV 851
Query: 841 PASSPEAPPAEQDP----------------------VQLKTQLEWTEAILEDEQTQRQKL 878
P+ PP Q+ V +K+ L W +++ D Q R
Sbjct: 852 PSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW-QSLRRDVQLIRSWS 910
Query: 879 TAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQ 938
A F + R +L L S+ ++RL E++ S LQ
Sbjct: 911 LATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQ 970
Query: 939 ELLKTTQEQLAREK--DTVKKLQEQLEKAE 966
L + QE+ ++ +K ++ QLE E
Sbjct: 971 SLEQGAQEESRCQRCISELKDIRLQLEACE 1000
Score = 37.7 bits (86), Expect = 0.053
Identities = 109/534 (20%), Positives = 200/534 (37%), Gaps = 48/534 (8%)
Query: 39 EEALANQR---KEMAKTHHQKVEK------------KKKEKTVEKKGKTKKKEEKPNGKI 83
EE LA QR ++M K Q V++ ++KE E+ + ++ +E+ ++
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 84 PDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKE 143
+ T+ E R + ++ + + VA ++ A +E K ++
Sbjct: 2358 AEETQGFQRTL---EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414
Query: 144 KKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKK 203
+K+ + E A V +Q L + + + R E K + AK +
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474
Query: 204 KGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGI---IQDTWHKATQKGD 260
+ L + L + S + + +R IE EKA + QD KA Q +
Sbjct: 2475 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE--QEKAKLEQLFQDEVAKAQQLRE 2532
Query: 261 PVAILKRQLEEKEKLLATEQEDAA----VAKSKLRELNKEM-AAEKAKAAAGEAKVKKQL 315
++Q+E++ + L E+A A+ +R +E+ E+ + E ++
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2592
Query: 316 VAREQ-EITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRD 374
REQ ++ Q R ++ E V Q K +GP + + + R
Sbjct: 2593 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRK 2652
Query: 375 ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVL 434
Q + EL +L Q + V + + + E VR Q R ++ + L
Sbjct: 2653 VSAQRLQEAGILSAEELQRLAQGHTTVDE--LARREDVRHYLQGRSSIAGLLLKATNEKL 2710
Query: 435 QLQASHRESEEALQKRLDEVSRELCHTQSSHAS---------LRADAEKAQEQQQQMAEL 485
+ A ALQ++L L ++ AS R +A ++ EL
Sbjct: 2711 SVYA-------ALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPEL 2763
Query: 486 HSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTER-IRSIEALLEAGQARD 538
H KL S+E V + +G L +A + + E IR +EA + G D
Sbjct: 2764 HHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVID 2817
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 132 bits (333), Expect = 1e-30
Identities = 221/1001 (22%), Positives = 413/1001 (41%), Gaps = 150/1001 (14%)
Query: 40 EALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREP 99
E A +++E+A+ Q++EK+++ + + ++E + +L E
Sbjct: 1648 EEQAVRQRELAE---QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1704
Query: 100 VRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNS 159
R A A T + + A +A V A + LAS + +++ K + + +
Sbjct: 1705 ARLQREAAAATQKRQEL-EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1763
Query: 160 IQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKT 219
+ L +AA L +E + +A +Q A A++ K +A T
Sbjct: 1764 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA---------T 1814
Query: 220 LVSTVGSMVFNEGEAQ--RLIEILSEKAGII-----QDTWHKAT---------------- 256
+ T + E EA+ RL + ++A Q HKA
Sbjct: 1815 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1874
Query: 257 --QKG--DPVAILKRQLEEKEKLLATEQEDAAVAKSKL-----------------RELNK 295
QKG + +RQ+EE+ L E AA K++L +E +
Sbjct: 1875 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1934
Query: 296 EMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKI---RTLQE 352
AA + + AA E + +++ R Q+ A + + ++EV++L+ K+ R L+E
Sbjct: 1935 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 1994
Query: 353 QLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAV 412
+ E QL Q+ A +A + ++ EL + Q+ V +L ++EA
Sbjct: 1995 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2054
Query: 413 R----QDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDE--VSRELCHTQSSHA 466
R + E+ R E +AA +QV + + + +EE Q R + +L A
Sbjct: 2055 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2114
Query: 467 SLRADAEKAQEQQQQMA--ELHSKLQSSEAEVRSKCE---ELSGLHGQLQEARAENSQLT 521
+ RA AE+A +Q+Q A E+ + +E +R K + EL+ L QL+E + + L
Sbjct: 2115 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2174
Query: 522 ERIRSIEALLEAGQA-RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQ 580
E ++ ++A EA +A R V+ Q L +L++++ E A+ LR+ Q
Sbjct: 2175 EELQRLKA--EATEAARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQ 2231
Query: 581 KVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPE 640
+ + EK + E A A +E A+E+ +Q L E E + A+
Sbjct: 2232 RFLQEEA-EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2290
Query: 641 LSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQS---TLQAECDQ 697
+ A+ + ++L ++ L+ E +A +L AEETQ TL+AE +
Sbjct: 2291 TRLKAEAELLQQQKELAQEQARRLQ------EDKEQMAQQL--AEETQGFQRTLEAERQR 2342
Query: 698 YRSILAETEGM------LRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKL 751
+ AE E + + Q EE+ Q +R + E+L ++ + + +V+ L
Sbjct: 2343 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2402
Query: 752 KGELESSD----QVREHTSHLEAELEK-HMAAASAECQNYAKEVAGLRQLLLESQSQLDA 806
+ + + SD ++RE + LE E EK A + ++ + QLL E+Q+ +
Sbjct: 2403 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2462
Query: 807 AKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEA 866
SE + Q+ ++++ +D ++A A QL+ + + +
Sbjct: 2463 FLSEKDSLLQRERFIEQEKAKLEQLFQD-EVAKAQ--------------QLREEQQRQQQ 2507
Query: 867 ILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKL 926
+E E RQ+L A EEA+ +E + + + EE QL+++
Sbjct: 2508 QMEQE---RQRLVASMEEARRRQHEAEEGVRR----------KQEELQQLEQQ------- 2547
Query: 927 TSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAED 967
+ QE+L E++ ++L+EQL+ E+
Sbjct: 2548 ---------------RRQQEELLAEEN--QRLREQLQLLEE 2571
Score = 131 bits (329), Expect = 4e-30
Identities = 191/766 (24%), Positives = 334/766 (43%), Gaps = 108/766 (14%)
Query: 267 RQLEEKEKLL----ATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEI 322
R++EE+E+L A E+E A ++ L E +++A A+A A + K+L R QE
Sbjct: 1310 RRMEEEERLAEQQRAEERERLAEVEAAL-EKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1368
Query: 323 T------AVQARMQA-SYREHVKEVQQL-QGKIRTLQEQLENGPNTQLARLQQENSILRD 374
AV A+ Q S +E +++++Q + +I+ Q E ++L R+++E ++R
Sbjct: 1369 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVVRL 1427
Query: 375 ALNQATSQVESKQNAELAKLR---QELSKVSKELVEKSEAVR---QDEQQRKA------- 421
L +AT + EL LR +E ++ E++E +R QDE QRK
Sbjct: 1428 QL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1486
Query: 422 ----LEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHT---------QSSHASL 468
EA+AA +++ LQ R E ++RL + E +S+ A L
Sbjct: 1487 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1546
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTER--IRS 526
++ E+ Q+ + + A++R + E + + + AR E + ER +++
Sbjct: 1547 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1606
Query: 527 IEALLEAGQARD-AQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNN 585
EAL QA + AQ +QAEA++Q+ + + E++A+ RE EQ+ K
Sbjct: 1607 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1666
Query: 586 DLREKNWKAMEALATAEQ--ACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSV 643
L E TA+Q A +++L L E+ E+Q L+E + LA L +
Sbjct: 1667 QLAE---------GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAA 1712
Query: 644 LAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQST-------LQAECD 696
A Q E +L + AE LASK R EE++ST L+AE
Sbjct: 1713 AATQKRQELEAELAK----------VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1762
Query: 697 QYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELE 756
++R LAE LR L + + + Q+ A+ AA + + RV + L I E + + E
Sbjct: 1763 RFRE-LAEEAARLRALAEEAKRQRQL--AEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1819
Query: 757 SSDQVREHTSHLEAELEKHMAAASAEC-----------QNYAKEVAGLRQLLLESQSQLD 805
+ ++E EAE E+ A E Q+ A L QL S S+L+
Sbjct: 1820 AEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1875
Query: 806 AAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSP--EAPPAEQDPVQLKTQLEW 863
K + + V +++ +K+ E A +D ++ K Q E
Sbjct: 1876 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1935
Query: 864 TEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKE 923
A + ++ E EE + +EE + R A EE +LK ++E+
Sbjct: 1936 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA------LEEVERLKAKVEEA 1989
Query: 924 KKLTSDLGR-AATRLQELLKTTQEQLAREKD----TVKKLQEQLEK 964
++L + +A +LQ + Q++L E+ V++ +++L++
Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2035
Score = 125 bits (313), Expect = 3e-28
Identities = 182/812 (22%), Positives = 335/812 (41%), Gaps = 111/812 (13%)
Query: 231 EGEAQRLIEILSEKA--GIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKS 288
E E R +++ E A + K + A L+R L+E+ +A +E+A
Sbjct: 1524 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE---- 1579
Query: 289 KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIR 348
R ++ AE+A+ A + QL A E A++ R+QA K + Q +
Sbjct: 1580 --RRAQQQAEAERAREEAERELERWQLKANE----ALRLRLQAEEVAQQKSLAQAEA--- 1630
Query: 349 TLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEK 408
++Q E R + E +R A ++E ++ +Q L+ +EL+
Sbjct: 1631 --EKQKEEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLAEGTAQQRLA-AEQELIRL 1686
Query: 409 SEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASL 468
Q EQQR+ LE + A +++ +E E L K E+ L +
Sbjct: 1687 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1746
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERI--RS 526
R+ +EK++++ + A +L A +R+ EE +E A ER+
Sbjct: 1747 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1806
Query: 527 IEALLEAGQARDAQDVQASQAEADQ------------QQTRLKELESQ-VSGLEKEAIEL 573
+ A+ EA + + ++ + EA+ Q+ RL+E +Q + +E+ +L
Sbjct: 1807 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1866
Query: 574 REAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEA 633
R+A + + + L E + + A K K E E +L I + +
Sbjct: 1867 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1926
Query: 634 LLAL-LPELSVLAQ-QNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTL 691
L + EL Q Q E + +E + K A E + + L E E ++ +
Sbjct: 1927 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1986
Query: 692 Q--------AECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKH 743
+ AE + R + E QK ++ EE+ V E+ELQ+ T++
Sbjct: 1987 EEARRLRERAEQESARQLQLAQEA----AQKRLQAEEKAHAFAVQQKEQELQQ---TLQQ 2039
Query: 744 LEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAA------------SAECQNYAKEVA 791
+ ++++L+GE E++ + E + E+ A + SAE Q A+ A
Sbjct: 2040 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2099
Query: 792 GLRQLLLESQSQLDAAKSEAQKQSDELALVRQQL--SEMKSHVEDGDIAGAPASSPEAPP 849
L +++ +AA+ + Q+++ AL ++Q +EM+ H + A + +
Sbjct: 2100 QAAAEKLRKEAEQEAAR---RAQAEQAALRQKQAADAEMEKHKK-----FAEQTLRQKAQ 2151
Query: 850 AEQDPVQLKTQLEWT--EAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLES 907
EQ+ L+ QLE T + L DE+ QR L AE EA +++EEL +R
Sbjct: 2152 VEQELTTLRLQLEETDHQKNLLDEELQR--LKAEATEAARQRSQVEEELFSVRV------ 2203
Query: 908 SETEEASQLKERLEKE-----------------------KKLTSDLGRAATRLQE---LL 941
+ EE S+LK R+E E K++ + R + QE L
Sbjct: 2204 -QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2262
Query: 942 KTTQEQLAREKDTVKK-LQEQLEKAEDGSSSK 972
+ +E LA+++ +K L+E+++ ++ + K
Sbjct: 2263 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2294
Score = 120 bits (302), Expect = 5e-27
Identities = 226/1009 (22%), Positives = 419/1009 (41%), Gaps = 122/1009 (12%)
Query: 35 ETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKK--EEKPNGKIPDHDPAPNV 92
E +E ++E+ + V+ ++++++++++ + ++ E + K + A
Sbjct: 1355 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1414
Query: 93 TVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPA 152
+ + E +R + + T Q + + A +E A + +++ E+ +V+
Sbjct: 1415 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1474
Query: 153 VSSVVNSIQVLTSKA-AILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADG 211
+ L S+ A E A ++ R + +EA + + ++
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQV 1533
Query: 212 PLYLPYKTLVSTVGSM--VFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQL 269
L ++ + + S F E AQ L L E+ + +A ++ A +R
Sbjct: 1534 ALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1592
Query: 270 EEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
EE E+ L Q A A +LR +E+A +K+ A A EA+ +K+ RE AR
Sbjct: 1593 EEAERELERWQLKANEAL-RLRLQAEEVAQQKSLAQA-EAEKQKEEAERE-------ARR 1643
Query: 330 QASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNA 389
+ E ++L + Q QL G Q +QE LR Q Q + +
Sbjct: 1644 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE- 1702
Query: 390 ELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQK 449
ELA+L++E + +++ E + + + + L A A E++ ++ EA
Sbjct: 1703 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1762
Query: 450 RLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQ 509
R E++ E A LRA AE+A+ +Q+Q+AE + Q +EAE R E+L+ +
Sbjct: 1763 RFRELAEEA-------ARLRALAEEAK-RQRQLAEEDAARQRAEAE-RVLAEKLAAIGEA 1813
Query: 510 ----------LQEARAENSQLTERIRSIEAL----LEAGQARDAQDVQ--------ASQA 547
L+E AEN +L R+ EA LE A+ D++ AS +
Sbjct: 1814 TRLKTEAEIALKEKEAENERL-RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1872
Query: 548 EADQQQTRLKELESQVSGLEKEAIELREAVEQQ------------KVKNN---DLREKNW 592
E ++Q+ +++ Q +E+E + L+ + E+ ++++N LR K
Sbjct: 1873 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1932
Query: 593 KAMEA-----LATAEQA----CKEKLHSLTQAKEESEKQ--LCLIEAQTMEALLALLPEL 641
+EA LA E+ +E++ A+EE+ +Q L E + ++A + L
Sbjct: 1933 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 1992
Query: 642 SVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSI 701
A+Q LQ +E L+ AE + + ++ +E Q TLQ E +S+
Sbjct: 1993 RERAEQESARQLQLAQEAAQKRLQ-----AEEKAHAFAVQQKEQELQQTLQQE----QSV 2043
Query: 702 LAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQV 761
L + G +++ EE E+ A+V A E Q R E E+LK E Q
Sbjct: 2044 LDQLRGEAEAARRAAEEAEE---ARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQA 2095
Query: 762 REHTSHLEAELEKHMAAASAECQNYAK-EVAGLRQLLLESQSQLDAAKSEAQKQSDELAL 820
R + +A EK A E A+ E A LRQ + ++++ K A++ + A
Sbjct: 2096 R---AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAEQTLRQKAQ 2151
Query: 821 VRQQLSEMKSHVEDGDIAG------APASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQ 874
V Q+L+ ++ +E+ D EA A + Q++ +L +E+
Sbjct: 2152 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2211
Query: 875 RQKLTAE-----FEEAQTSACRLQEELEKLRT--------------AGPLESSETEEASQ 915
+ ++ AE + + LQEE EK++ A L E+ +Q
Sbjct: 2212 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2271
Query: 916 LKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEK 964
+ EK K + ATRL+ + Q+Q ++ ++LQE E+
Sbjct: 2272 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2320
Score = 113 bits (283), Expect = 8e-25
Identities = 192/851 (22%), Positives = 366/851 (43%), Gaps = 106/851 (12%)
Query: 183 AQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLV---STVGSMVFNE-GEAQRLI 238
AQ+ A E A K S K + +A P + + + VG + GE +
Sbjct: 1083 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1142
Query: 239 EILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMA 298
E E+ + + W + D + +R+LE+ + L +E A + L++ +
Sbjct: 1143 ERWRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1199
Query: 299 AEKAKAAAGEAKVKKQLVAREQEITAVQAR------MQASYREHVKEVQQLQGKIRTLQE 352
+A A V++QL + + ++ Q ++++ ++ + ++ T +
Sbjct: 1200 QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1259
Query: 353 QLEN--GPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSE 410
QLE P + S++++ ++ T +EL L + K E + + E
Sbjct: 1260 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHY------SELTTLTSQYIKFISETLRRME 1313
Query: 411 -----AVRQDEQQRKALEAKAAAFEKQVLQLQASH--------RESEEALQKRLDEVSRE 457
A +Q ++R+ L AA EKQ QL +H RE++E Q+ +EV R
Sbjct: 1314 EEERLAEQQRAEERERLAEVEAALEKQ-RQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1372
Query: 458 LCHTQSSHASLRADAEKAQE-QQQQMAELHSKLQSSEAEVRSKC---EEL---------- 503
+ R+ E+ Q+ +Q AE+ +K + +EA RS+ EE+
Sbjct: 1373 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1432
Query: 504 ----SGLHGQLQ--EARAENSQLTERIRSIEALL-------EAGQARDAQDVQASQAEAD 550
G G+LQ ARAE ++ +R EA E+ + R A+ AS+ +A+
Sbjct: 1433 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1492
Query: 551 QQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLH 610
+ R E + + LE+ ++ EA +++++ ++ E+ + AL TA+++ + +L
Sbjct: 1493 AEAAR--EKQRALQALEELRLQAEEA--ERRLRQAEV-ERARQVQVALETAQRSAEAELQ 1547
Query: 611 SLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAP 670
S + E QL + A+ L E AQQ + +E+ L+
Sbjct: 1548 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE--AERAREEAERELERWQLK 1605
Query: 671 AEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAA 730
A + L + E + +S QAE ++ + E R+ ++ + EEQ R + A
Sbjct: 1606 ANEALRLRLQAEEVAQQKSLAQAEAEK------QKEEAEREARRRGKAEEQAVRQR-ELA 1658
Query: 731 EEELQKSRVTVK-------HLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAEC 783
E+EL+K R + E+ + +L+ E E +Q R+ A L++ AAA+ +
Sbjct: 1659 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1718
Query: 784 QNYAKEVAGLR---QLLLESQSQLD---AAKSEAQKQSDELALVR-QQLSEMKSHVEDGD 836
Q E+A +R ++LL S+++ + + SE KQ E R ++L+E + +
Sbjct: 1719 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR--- 1775
Query: 837 IAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEEL 896
A A + + AE+D + + + E +L ++ + T EA+ + + E
Sbjct: 1776 -ALAEEAKRQRQLAEEDAARQRAE---AERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1831
Query: 897 EKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVK 956
E+LR L E + +L+E+ + K +D+ RL +L K + +L R+K V+
Sbjct: 1832 ERLRR---LAEDEAFQRRRLEEQAAQHK---ADI---EERLAQLRKASDSELERQKGLVE 1882
Query: 957 KLQEQLEKAED 967
Q + E+
Sbjct: 1883 DTLRQRRQVEE 1893
Score = 111 bits (278), Expect = 3e-24
Identities = 176/765 (23%), Positives = 322/765 (42%), Gaps = 117/765 (15%)
Query: 266 KRQLEEK-EKLLATEQEDAAVAKSKLRELNKEMA----AEKAKAAAGEAKVKKQLVAREQ 320
+R+ EE+ +K LA E+E A K+ L E+ + A A + + A + ++ +A+E
Sbjct: 1951 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE- 2009
Query: 321 EITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQAT 380
A Q R+QA + H VQQ K + LQ+ L QQE S+L +A
Sbjct: 2010 ---AAQKRLQAEEKAHAFAVQQ---KEQELQQTL-----------QQEQSVLDQLRGEAE 2052
Query: 381 SQVESKQNAELAKLRQELSKV-SKELVEKSEAVRQ--DEQQRKALEAKAAA--FEKQVLQ 435
+ + + AE A+++ E S+ VE++E ++Q +EQ + +A+AAA K+ Q
Sbjct: 2053 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2112
Query: 436 LQASHRESEEALQKRLDEVSREL-CHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEA 494
A ++E+A ++ E+ H + + +LR +KAQ +Q+ + L +L+ ++
Sbjct: 2113 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR---QKAQVEQE-LTTLRLQLEETDH 2168
Query: 495 EVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLE--------------AGQARDAQ 540
+ EEL L + EA + SQ+ E + S+ +E A RD
Sbjct: 2169 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2228
Query: 541 DVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAM----- 595
+ Q E ++ ++ E +++S +EA LR+ E+ + L EK K
Sbjct: 2229 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2288
Query: 596 ---------EALATAEQACKEKLHSLTQAKEESEKQLC--------------------LI 626
E L ++ +E+ L + KE+ +QL
Sbjct: 2289 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2348
Query: 627 EAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEE 686
EA+ ++ +A + A+++ + + +E G L + A E + L L E +
Sbjct: 2349 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTL-EIQR 2406
Query: 687 TQSTLQAECDQYRSILAETEGMLRDLQKSV-------EEEEQVWRAKVGAAEEELQKSRV 739
QS AE + R +AE E LQ+ EE + V + ++ + LQ+S +
Sbjct: 2407 QQSDHDAE--RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2464
Query: 740 TVK----HLEEIVEKLKGELES--------SDQVREHTSHLEAELEKHMAAASAECQNYA 787
+ K E +E+ K +LE + Q+RE + ++E+ A +
Sbjct: 2465 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2524
Query: 788 KEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEA 847
+ + + Q +L + + ++Q + LA Q+L E +E+ A A A S E
Sbjct: 2525 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA-ALAHSEEV 2583
Query: 848 PPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLES 907
++ KT +A+ + + + + SA RLQE AG L +
Sbjct: 2584 TASQ--VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE-------AGILSA 2634
Query: 908 SETEEASQ---LKERLEKEKKLTSDLGRAATRLQELLKTTQEQLA 949
E + +Q + L + + + L ++ LLK T E+L+
Sbjct: 2635 EELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLS 2679
Score = 91.3 bits (225), Expect = 4e-18
Identities = 142/624 (22%), Positives = 248/624 (39%), Gaps = 69/624 (11%)
Query: 364 RLQQENSILRDALNQATSQVESKQNAE-LAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
RL + R+ + Q +++ E L K LS +++++ E R L
Sbjct: 976 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1035
Query: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM 482
E E QV L A + E +L +S + TQ + LRA E+ +E Q
Sbjct: 1036 ELTLGKLE-QVRSLSAIYLE-------KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1087
Query: 483 AEL------HSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQA 536
A L + L+ A+ ++ L +L+ A+ +L +R + +E +
Sbjct: 1088 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1147
Query: 537 RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAME 596
R AQ ++ QA Q R +ELE L ++ RE+ + D R + +
Sbjct: 1148 RVAQLLERWQAVLAQTDVRQRELEQ----LGRQLRYYRESADPLGAWLQDARRRQEQIQA 1203
Query: 597 ALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDL 656
QA +E+L EE E+ +E Q+ +++ +
Sbjct: 1204 MPLADSQAVREQLRQEQALLEEIERHGEKVEE----------------CQRFAKQYINAI 1247
Query: 657 KEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSV 716
K+ L+ + A EP + A K + ++S +Q D R+ +E + K +
Sbjct: 1248 KDYELQLVTYK-AQLEPVASPAKKPKVQSGSESVIQEYVD-LRTHYSELTTLTSQYIKFI 1305
Query: 717 EEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHM 776
E T++ +EE E+ E + +++ RE + +EA LEK
Sbjct: 1306 SE---------------------TLRRMEE--EERLAEQQRAEE-RERLAEVEAALEKQR 1341
Query: 777 AAASAECQNYA---KEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVE 833
A A Q A +E L+Q + E + + A +AQ+Q + QQL +
Sbjct: 1342 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1401
Query: 834 DGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQ 893
A A+ E++ ++ QLE TE + + Q L A EEA+ + Q
Sbjct: 1402 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1461
Query: 894 EELEKLRTAGPLESSETEEAS-QLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAR-- 950
EE E+LR ES +A +L R++ E + + RA L+EL +E R
Sbjct: 1462 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1521
Query: 951 --EKDTVKKLQEQLEKAEDGSSSK 972
E + +++Q LE A+ + ++
Sbjct: 1522 QAEVERARQVQVALETAQRSAEAE 1545
Score = 76.3 bits (186), Expect = 1e-13
Identities = 119/582 (20%), Positives = 255/582 (43%), Gaps = 45/582 (7%)
Query: 143 EKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSK 202
++K +++ + + + L +A A +E V EA + ++ K
Sbjct: 2027 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2086
Query: 203 KKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDT-----WHKATQ 257
+ A + + E E + +E+A + Q K +
Sbjct: 2087 QSAEEQAQA------RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2140
Query: 258 KGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVA 317
+ K Q+E++ L + E+ K+ L E + + AE +AA ++V+++L +
Sbjct: 2141 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2200
Query: 318 ---REQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRD 374
+ +E++ ++AR++A R + ++ R LQE+ E ++ ++ +E + L
Sbjct: 2201 VRVQMEELSKLKARIEAENRALI--LRDKDNTQRFLQEEAE-----KMKQVAEEAARLSV 2253
Query: 375 ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVL 434
A +A +Q AE L Q+ + K L EK +AV+ E R EA+ +K++
Sbjct: 2254 AAQEAA---RLRQLAE-EDLAQQRALAEKMLKEKMQAVQ--EATRLKAEAELLQQQKELA 2307
Query: 435 QLQASH-RESEEALQKRLDEVSRELCHT----QSSHASLRADAEKAQEQQQQMAELHSKL 489
Q QA +E +E + ++L E ++ T + + A+AE+ + + +M+ ++
Sbjct: 2308 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2367
Query: 490 QSSEAEVRSKCEELSGLHGQLQEARAENSQL--TERIRSIEALLEAGQARDAQDVQASQA 547
+ R + EE+ + + A E L T I+ ++ +A + R+A +
Sbjct: 2368 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2427
Query: 548 EADQQQTRLKELESQ--VSGLEKEAIELREAVEQQKVKNND-LREKNWKAMEALATAEQA 604
E QQ+ +L +L+S+ + +++ ++ +A++Q + D L ++ + A EQ
Sbjct: 2428 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2487
Query: 605 CKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLL 664
++++ Q +EE ++Q +E Q + L+A + E A++ E + ++ K L
Sbjct: 2488 FQDEVAKAQQLREEQQRQQQQME-QERQRLVASMEE----ARRRQHEAEEGVRRKQEELQ 2542
Query: 665 KHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETE 706
+ + LA E + + LQ +Q+R+ LA +E
Sbjct: 2543 QLEQQRRQQEELLA---EENQRLREQLQLLEEQHRAALAHSE 2581
Score = 52.4 bits (124), Expect = 2e-06
Identities = 169/750 (22%), Positives = 280/750 (37%), Gaps = 152/750 (20%)
Query: 295 KEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKI------- 347
KEM +A +K Q + E + A Q ++ Y H +V++ GK+
Sbjct: 293 KEMELPAKEADKNRSKGIYQSL--EGAVQAGQLKVPPGY--HPLDVEKEWGKLHVAILER 348
Query: 348 -RTLQEQLENGPNTQ--LARLQQENSILRDALNQATSQVESKQNAELA-KLRQELSKVSK 403
+ L+ + E Q + +LQ E + + LNQA + ++S A K+ Q +V +
Sbjct: 349 EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVER 408
Query: 404 ELVEKSEAVR---------------QDEQQRKAL----EAKAAAFEKQVLQLQAS-HRES 443
+L + +R Q EQ + + E A + L+L+A +
Sbjct: 409 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 468
Query: 444 EEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM--AELHSKLQSSEAEVRSKCE 501
+ Q L V R S+ L+ +E Q ++ AE L S EA++ S
Sbjct: 469 TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH-- 526
Query: 502 ELSGLHGQLQEARAENSQLTERIRSIEALLEA---GQARDAQ---DVQASQAEADQQQTR 555
GLH ++E RA+ ER RS E L G RD D+Q ++ + + R
Sbjct: 527 --RGLHQSIEEFRAK----IERARSDEGQLSPATRGAYRDCLGRLDLQYAKL-LNSSKAR 579
Query: 556 LKELESQ---VSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSL 612
L+ LES V+ KE + L E E++ D ++N T A KE +L
Sbjct: 580 LRSLESLHSFVAAATKELMWLNEKEEEEV--GFDWSDRN--------TNMTAKKESYSAL 629
Query: 613 TQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLK--HPPAP 670
+ E EK++ ++L+ G LL+ HP P
Sbjct: 630 MRELELKEKKI------------------------------KELQNAGDRLLREDHPARP 659
Query: 671 AEPSSDLASKLREAEETQSTLQAECD--------QYRSILAETEGMLRDLQKSVEEEEQV 722
S A + + + Q E Q+ S + E EG L+ LQ+++ +
Sbjct: 660 TVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSC 719
Query: 723 WRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAE 782
R+ TV LE++++ + E E Q+ E+ HL ++ A +
Sbjct: 720 DRS-------------ATVTRLEDLLQDAQDEKE---QLNEYKGHLSGLAKRAKAVVQLK 763
Query: 783 CQNYAKEVAGLRQLLLESQSQLDAAKSEAQ-KQSDELALV-RQQLSEMKSHVEDGDIAGA 840
++ A + G LL + D + E + DE LV Q S K G A
Sbjct: 764 PRHPAHPMRGRLPLL----AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAV 819
Query: 841 PASSPEAPPAEQDP----------------------VQLKTQLEWTEAILEDEQTQRQKL 878
P+ PP Q+ V +K+ L W +++ D Q R
Sbjct: 820 PSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW-QSLRRDVQLIRSWS 878
Query: 879 TAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQ 938
A F + R +L L S+ ++RL E++ S LQ
Sbjct: 879 LATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQ 938
Query: 939 ELLKTTQEQLAREK--DTVKKLQEQLEKAE 966
L + QE+ ++ +K ++ QLE E
Sbjct: 939 SLEQGAQEESRCQRCISELKDIRLQLEACE 968
Score = 37.7 bits (86), Expect = 0.053
Identities = 109/534 (20%), Positives = 200/534 (37%), Gaps = 48/534 (8%)
Query: 39 EEALANQR---KEMAKTHHQKVEK------------KKKEKTVEKKGKTKKKEEKPNGKI 83
EE LA QR ++M K Q V++ ++KE E+ + ++ +E+ ++
Sbjct: 2266 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2325
Query: 84 PDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKE 143
+ T+ E R + ++ + + VA ++ A +E K ++
Sbjct: 2326 AEETQGFQRTL---EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2382
Query: 144 KKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKK 203
+K+ + E A V +Q L + + + R E K + AK +
Sbjct: 2383 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2442
Query: 204 KGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGI---IQDTWHKATQKGD 260
+ L + L + S + + +R IE EKA + QD KA Q +
Sbjct: 2443 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE--QEKAKLEQLFQDEVAKAQQLRE 2500
Query: 261 PVAILKRQLEEKEKLLATEQEDAA----VAKSKLRELNKEM-AAEKAKAAAGEAKVKKQL 315
++Q+E++ + L E+A A+ +R +E+ E+ + E ++
Sbjct: 2501 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2560
Query: 316 VAREQ-EITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRD 374
REQ ++ Q R ++ E V Q K +GP + + + R
Sbjct: 2561 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRK 2620
Query: 375 ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVL 434
Q + EL +L Q + V + + + E VR Q R ++ + L
Sbjct: 2621 VSAQRLQEAGILSAEELQRLAQGHTTVDE--LARREDVRHYLQGRSSIAGLLLKATNEKL 2678
Query: 435 QLQASHRESEEALQKRLDEVSRELCHTQSSHAS---------LRADAEKAQEQQQQMAEL 485
+ A ALQ++L L ++ AS R +A ++ EL
Sbjct: 2679 SVYA-------ALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPEL 2731
Query: 486 HSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTER-IRSIEALLEAGQARD 538
H KL S+E V + +G L +A + + E IR +EA + G D
Sbjct: 2732 HHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVID 2785
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 132 bits (333), Expect = 1e-30
Identities = 221/1001 (22%), Positives = 413/1001 (41%), Gaps = 150/1001 (14%)
Query: 40 EALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREP 99
E A +++E+A+ Q++EK+++ + + ++E + +L E
Sbjct: 1817 EEQAVRQRELAE---QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1873
Query: 100 VRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNS 159
R A A T + + A +A V A + LAS + +++ K + + +
Sbjct: 1874 ARLQREAAAATQKRQEL-EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1932
Query: 160 IQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKT 219
+ L +AA L +E + +A +Q A A++ K +A T
Sbjct: 1933 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA---------T 1983
Query: 220 LVSTVGSMVFNEGEAQ--RLIEILSEKAGII-----QDTWHKAT---------------- 256
+ T + E EA+ RL + ++A Q HKA
Sbjct: 1984 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 2043
Query: 257 --QKG--DPVAILKRQLEEKEKLLATEQEDAAVAKSKL-----------------RELNK 295
QKG + +RQ+EE+ L E AA K++L +E +
Sbjct: 2044 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 2103
Query: 296 EMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKI---RTLQE 352
AA + + AA E + +++ R Q+ A + + ++EV++L+ K+ R L+E
Sbjct: 2104 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2163
Query: 353 QLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAV 412
+ E QL Q+ A +A + ++ EL + Q+ V +L ++EA
Sbjct: 2164 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2223
Query: 413 R----QDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDE--VSRELCHTQSSHA 466
R + E+ R E +AA +QV + + + +EE Q R + +L A
Sbjct: 2224 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283
Query: 467 SLRADAEKAQEQQQQMA--ELHSKLQSSEAEVRSKCE---ELSGLHGQLQEARAENSQLT 521
+ RA AE+A +Q+Q A E+ + +E +R K + EL+ L QL+E + + L
Sbjct: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343
Query: 522 ERIRSIEALLEAGQA-RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQ 580
E ++ ++A EA +A R V+ Q L +L++++ E A+ LR+ Q
Sbjct: 2344 EELQRLKA--EATEAARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQ 2400
Query: 581 KVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPE 640
+ + EK + E A A +E A+E+ +Q L E E + A+
Sbjct: 2401 RFLQEEA-EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2459
Query: 641 LSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQS---TLQAECDQ 697
+ A+ + ++L ++ L+ E +A +L AEETQ TL+AE +
Sbjct: 2460 TRLKAEAELLQQQKELAQEQARRLQ------EDKEQMAQQL--AEETQGFQRTLEAERQR 2511
Query: 698 YRSILAETEGM------LRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKL 751
+ AE E + + Q EE+ Q +R + E+L ++ + + +V+ L
Sbjct: 2512 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2571
Query: 752 KGELESSD----QVREHTSHLEAELEK-HMAAASAECQNYAKEVAGLRQLLLESQSQLDA 806
+ + + SD ++RE + LE E EK A + ++ + QLL E+Q+ +
Sbjct: 2572 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2631
Query: 807 AKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEA 866
SE + Q+ ++++ +D ++A A QL+ + + +
Sbjct: 2632 FLSEKDSLLQRERFIEQEKAKLEQLFQD-EVAKAQ--------------QLREEQQRQQQ 2676
Query: 867 ILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKL 926
+E E RQ+L A EEA+ +E + + + EE QL+++
Sbjct: 2677 QMEQE---RQRLVASMEEARRRQHEAEEGVRR----------KQEELQQLEQQ------- 2716
Query: 927 TSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAED 967
+ QE+L E++ ++L+EQL+ E+
Sbjct: 2717 ---------------RRQQEELLAEEN--QRLREQLQLLEE 2740
Score = 131 bits (329), Expect = 4e-30
Identities = 191/766 (24%), Positives = 334/766 (43%), Gaps = 108/766 (14%)
Query: 267 RQLEEKEKLL----ATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEI 322
R++EE+E+L A E+E A ++ L E +++A A+A A + K+L R QE
Sbjct: 1479 RRMEEEERLAEQQRAEERERLAEVEAAL-EKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1537
Query: 323 T------AVQARMQA-SYREHVKEVQQL-QGKIRTLQEQLENGPNTQLARLQQENSILRD 374
AV A+ Q S +E +++++Q + +I+ Q E ++L R+++E ++R
Sbjct: 1538 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVVRL 1596
Query: 375 ALNQATSQVESKQNAELAKLR---QELSKVSKELVEKSEAVR---QDEQQRKA------- 421
L +AT + EL LR +E ++ E++E +R QDE QRK
Sbjct: 1597 QL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1655
Query: 422 ----LEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHT---------QSSHASL 468
EA+AA +++ LQ R E ++RL + E +S+ A L
Sbjct: 1656 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1715
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTER--IRS 526
++ E+ Q+ + + A++R + E + + + AR E + ER +++
Sbjct: 1716 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1775
Query: 527 IEALLEAGQARD-AQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNN 585
EAL QA + AQ +QAEA++Q+ + + E++A+ RE EQ+ K
Sbjct: 1776 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1835
Query: 586 DLREKNWKAMEALATAEQ--ACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSV 643
L E TA+Q A +++L L E+ E+Q L+E + LA L +
Sbjct: 1836 QLAE---------GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAA 1881
Query: 644 LAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQST-------LQAECD 696
A Q E +L + AE LASK R EE++ST L+AE
Sbjct: 1882 AATQKRQELEAELAK----------VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1931
Query: 697 QYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELE 756
++R LAE LR L + + + Q+ A+ AA + + RV + L I E + + E
Sbjct: 1932 RFRE-LAEEAARLRALAEEAKRQRQL--AEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1988
Query: 757 SSDQVREHTSHLEAELEKHMAAASAEC-----------QNYAKEVAGLRQLLLESQSQLD 805
+ ++E EAE E+ A E Q+ A L QL S S+L+
Sbjct: 1989 AEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 2044
Query: 806 AAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSP--EAPPAEQDPVQLKTQLEW 863
K + + V +++ +K+ E A +D ++ K Q E
Sbjct: 2045 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 2104
Query: 864 TEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKE 923
A + ++ E EE + +EE + R A EE +LK ++E+
Sbjct: 2105 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA------LEEVERLKAKVEEA 2158
Query: 924 KKLTSDLGR-AATRLQELLKTTQEQLAREKD----TVKKLQEQLEK 964
++L + +A +LQ + Q++L E+ V++ +++L++
Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2204
Score = 125 bits (313), Expect = 3e-28
Identities = 182/812 (22%), Positives = 335/812 (41%), Gaps = 111/812 (13%)
Query: 231 EGEAQRLIEILSEKA--GIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKS 288
E E R +++ E A + K + A L+R L+E+ +A +E+A
Sbjct: 1693 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE---- 1748
Query: 289 KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIR 348
R ++ AE+A+ A + QL A E A++ R+QA K + Q +
Sbjct: 1749 --RRAQQQAEAERAREEAERELERWQLKANE----ALRLRLQAEEVAQQKSLAQAEA--- 1799
Query: 349 TLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEK 408
++Q E R + E +R A ++E ++ +Q L+ +EL+
Sbjct: 1800 --EKQKEEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLAEGTAQQRLA-AEQELIRL 1855
Query: 409 SEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASL 468
Q EQQR+ LE + A +++ +E E L K E+ L +
Sbjct: 1856 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1915
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERI--RS 526
R+ +EK++++ + A +L A +R+ EE +E A ER+
Sbjct: 1916 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1975
Query: 527 IEALLEAGQARDAQDVQASQAEADQ------------QQTRLKELESQ-VSGLEKEAIEL 573
+ A+ EA + + ++ + EA+ Q+ RL+E +Q + +E+ +L
Sbjct: 1976 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 2035
Query: 574 REAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEA 633
R+A + + + L E + + A K K E E +L I + +
Sbjct: 2036 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 2095
Query: 634 LLAL-LPELSVLAQ-QNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTL 691
L + EL Q Q E + +E + K A E + + L E E ++ +
Sbjct: 2096 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2155
Query: 692 Q--------AECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKH 743
+ AE + R + E QK ++ EE+ V E+ELQ+ T++
Sbjct: 2156 EEARRLRERAEQESARQLQLAQEA----AQKRLQAEEKAHAFAVQQKEQELQQ---TLQQ 2208
Query: 744 LEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAA------------SAECQNYAKEVA 791
+ ++++L+GE E++ + E + E+ A + SAE Q A+ A
Sbjct: 2209 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2268
Query: 792 GLRQLLLESQSQLDAAKSEAQKQSDELALVRQQL--SEMKSHVEDGDIAGAPASSPEAPP 849
L +++ +AA+ + Q+++ AL ++Q +EM+ H + A + +
Sbjct: 2269 QAAAEKLRKEAEQEAAR---RAQAEQAALRQKQAADAEMEKHKK-----FAEQTLRQKAQ 2320
Query: 850 AEQDPVQLKTQLEWT--EAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLES 907
EQ+ L+ QLE T + L DE+ QR L AE EA +++EEL +R
Sbjct: 2321 VEQELTTLRLQLEETDHQKNLLDEELQR--LKAEATEAARQRSQVEEELFSVRV------ 2372
Query: 908 SETEEASQLKERLEKE-----------------------KKLTSDLGRAATRLQE---LL 941
+ EE S+LK R+E E K++ + R + QE L
Sbjct: 2373 -QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2431
Query: 942 KTTQEQLAREKDTVKK-LQEQLEKAEDGSSSK 972
+ +E LA+++ +K L+E+++ ++ + K
Sbjct: 2432 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2463
Score = 120 bits (302), Expect = 5e-27
Identities = 226/1009 (22%), Positives = 419/1009 (41%), Gaps = 122/1009 (12%)
Query: 35 ETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKK--EEKPNGKIPDHDPAPNV 92
E +E ++E+ + V+ ++++++++++ + ++ E + K + A
Sbjct: 1524 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1583
Query: 93 TVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPA 152
+ + E +R + + T Q + + A +E A + +++ E+ +V+
Sbjct: 1584 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643
Query: 153 VSSVVNSIQVLTSKA-AILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADG 211
+ L S+ A E A ++ R + +EA + + ++
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQV 1702
Query: 212 PLYLPYKTLVSTVGSM--VFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQL 269
L ++ + + S F E AQ L L E+ + +A ++ A +R
Sbjct: 1703 ALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1761
Query: 270 EEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
EE E+ L Q A A +LR +E+A +K+ A A EA+ +K+ RE AR
Sbjct: 1762 EEAERELERWQLKANEAL-RLRLQAEEVAQQKSLAQA-EAEKQKEEAERE-------ARR 1812
Query: 330 QASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNA 389
+ E ++L + Q QL G Q +QE LR Q Q + +
Sbjct: 1813 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE- 1871
Query: 390 ELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQK 449
ELA+L++E + +++ E + + + + L A A E++ ++ EA
Sbjct: 1872 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1931
Query: 450 RLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQ 509
R E++ E A LRA AE+A+ +Q+Q+AE + Q +EAE R E+L+ +
Sbjct: 1932 RFRELAEEA-------ARLRALAEEAK-RQRQLAEEDAARQRAEAE-RVLAEKLAAIGEA 1982
Query: 510 ----------LQEARAENSQLTERIRSIEAL----LEAGQARDAQDVQ--------ASQA 547
L+E AEN +L R+ EA LE A+ D++ AS +
Sbjct: 1983 TRLKTEAEIALKEKEAENERL-RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 2041
Query: 548 EADQQQTRLKELESQVSGLEKEAIELREAVEQQ------------KVKNN---DLREKNW 592
E ++Q+ +++ Q +E+E + L+ + E+ ++++N LR K
Sbjct: 2042 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 2101
Query: 593 KAMEA-----LATAEQA----CKEKLHSLTQAKEESEKQ--LCLIEAQTMEALLALLPEL 641
+EA LA E+ +E++ A+EE+ +Q L E + ++A + L
Sbjct: 2102 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2161
Query: 642 SVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSI 701
A+Q LQ +E L+ AE + + ++ +E Q TLQ E +S+
Sbjct: 2162 RERAEQESARQLQLAQEAAQKRLQ-----AEEKAHAFAVQQKEQELQQTLQQE----QSV 2212
Query: 702 LAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQV 761
L + G +++ EE E+ A+V A E Q R E E+LK E Q
Sbjct: 2213 LDQLRGEAEAARRAAEEAEE---ARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQA 2264
Query: 762 REHTSHLEAELEKHMAAASAECQNYAK-EVAGLRQLLLESQSQLDAAKSEAQKQSDELAL 820
R + +A EK A E A+ E A LRQ + ++++ K A++ + A
Sbjct: 2265 R---AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAEQTLRQKAQ 2320
Query: 821 VRQQLSEMKSHVEDGDIAG------APASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQ 874
V Q+L+ ++ +E+ D EA A + Q++ +L +E+
Sbjct: 2321 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2380
Query: 875 RQKLTAE-----FEEAQTSACRLQEELEKLRT--------------AGPLESSETEEASQ 915
+ ++ AE + + LQEE EK++ A L E+ +Q
Sbjct: 2381 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2440
Query: 916 LKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEK 964
+ EK K + ATRL+ + Q+Q ++ ++LQE E+
Sbjct: 2441 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2489
Score = 113 bits (283), Expect = 8e-25
Identities = 192/851 (22%), Positives = 366/851 (43%), Gaps = 106/851 (12%)
Query: 183 AQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLV---STVGSMVFNE-GEAQRLI 238
AQ+ A E A K S K + +A P + + + VG + GE +
Sbjct: 1252 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1311
Query: 239 EILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMA 298
E E+ + + W + D + +R+LE+ + L +E A + L++ +
Sbjct: 1312 ERWRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1368
Query: 299 AEKAKAAAGEAKVKKQLVAREQEITAVQAR------MQASYREHVKEVQQLQGKIRTLQE 352
+A A V++QL + + ++ Q ++++ ++ + ++ T +
Sbjct: 1369 QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1428
Query: 353 QLEN--GPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSE 410
QLE P + S++++ ++ T +EL L + K E + + E
Sbjct: 1429 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHY------SELTTLTSQYIKFISETLRRME 1482
Query: 411 -----AVRQDEQQRKALEAKAAAFEKQVLQLQASH--------RESEEALQKRLDEVSRE 457
A +Q ++R+ L AA EKQ QL +H RE++E Q+ +EV R
Sbjct: 1483 EEERLAEQQRAEERERLAEVEAALEKQ-RQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1541
Query: 458 LCHTQSSHASLRADAEKAQE-QQQQMAELHSKLQSSEAEVRSKC---EEL---------- 503
+ R+ E+ Q+ +Q AE+ +K + +EA RS+ EE+
Sbjct: 1542 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1601
Query: 504 ----SGLHGQLQ--EARAENSQLTERIRSIEALL-------EAGQARDAQDVQASQAEAD 550
G G+LQ ARAE ++ +R EA E+ + R A+ AS+ +A+
Sbjct: 1602 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1661
Query: 551 QQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLH 610
+ R E + + LE+ ++ EA +++++ ++ E+ + AL TA+++ + +L
Sbjct: 1662 AEAAR--EKQRALQALEELRLQAEEA--ERRLRQAEV-ERARQVQVALETAQRSAEAELQ 1716
Query: 611 SLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAP 670
S + E QL + A+ L E AQQ + +E+ L+
Sbjct: 1717 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE--AERAREEAERELERWQLK 1774
Query: 671 AEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAA 730
A + L + E + +S QAE ++ + E R+ ++ + EEQ R + A
Sbjct: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEK------QKEEAEREARRRGKAEEQAVRQR-ELA 1827
Query: 731 EEELQKSRVTVK-------HLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAEC 783
E+EL+K R + E+ + +L+ E E +Q R+ A L++ AAA+ +
Sbjct: 1828 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1887
Query: 784 QNYAKEVAGLR---QLLLESQSQLD---AAKSEAQKQSDELALVR-QQLSEMKSHVEDGD 836
Q E+A +R ++LL S+++ + + SE KQ E R ++L+E + +
Sbjct: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR--- 1944
Query: 837 IAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEEL 896
A A + + AE+D + + + E +L ++ + T EA+ + + E
Sbjct: 1945 -ALAEEAKRQRQLAEEDAARQRAE---AERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 2000
Query: 897 EKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVK 956
E+LR L E + +L+E+ + K +D+ RL +L K + +L R+K V+
Sbjct: 2001 ERLRR---LAEDEAFQRRRLEEQAAQHK---ADI---EERLAQLRKASDSELERQKGLVE 2051
Query: 957 KLQEQLEKAED 967
Q + E+
Sbjct: 2052 DTLRQRRQVEE 2062
Score = 111 bits (278), Expect = 3e-24
Identities = 176/765 (23%), Positives = 322/765 (42%), Gaps = 117/765 (15%)
Query: 266 KRQLEEK-EKLLATEQEDAAVAKSKLRELNKEMA----AEKAKAAAGEAKVKKQLVAREQ 320
+R+ EE+ +K LA E+E A K+ L E+ + A A + + A + ++ +A+E
Sbjct: 2120 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE- 2178
Query: 321 EITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQAT 380
A Q R+QA + H VQQ K + LQ+ L QQE S+L +A
Sbjct: 2179 ---AAQKRLQAEEKAHAFAVQQ---KEQELQQTL-----------QQEQSVLDQLRGEAE 2221
Query: 381 SQVESKQNAELAKLRQELSKV-SKELVEKSEAVRQ--DEQQRKALEAKAAA--FEKQVLQ 435
+ + + AE A+++ E S+ VE++E ++Q +EQ + +A+AAA K+ Q
Sbjct: 2222 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2281
Query: 436 LQASHRESEEALQKRLDEVSREL-CHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEA 494
A ++E+A ++ E+ H + + +LR +KAQ +Q+ + L +L+ ++
Sbjct: 2282 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR---QKAQVEQE-LTTLRLQLEETDH 2337
Query: 495 EVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLE--------------AGQARDAQ 540
+ EEL L + EA + SQ+ E + S+ +E A RD
Sbjct: 2338 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2397
Query: 541 DVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAM----- 595
+ Q E ++ ++ E +++S +EA LR+ E+ + L EK K
Sbjct: 2398 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2457
Query: 596 ---------EALATAEQACKEKLHSLTQAKEESEKQLC--------------------LI 626
E L ++ +E+ L + KE+ +QL
Sbjct: 2458 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2517
Query: 627 EAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEE 686
EA+ ++ +A + A+++ + + +E G L + A E + L L E +
Sbjct: 2518 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTL-EIQR 2575
Query: 687 TQSTLQAECDQYRSILAETEGMLRDLQKSV-------EEEEQVWRAKVGAAEEELQKSRV 739
QS AE + R +AE E LQ+ EE + V + ++ + LQ+S +
Sbjct: 2576 QQSDHDAE--RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2633
Query: 740 TVK----HLEEIVEKLKGELES--------SDQVREHTSHLEAELEKHMAAASAECQNYA 787
+ K E +E+ K +LE + Q+RE + ++E+ A +
Sbjct: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2693
Query: 788 KEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEA 847
+ + + Q +L + + ++Q + LA Q+L E +E+ A A A S E
Sbjct: 2694 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA-ALAHSEEV 2752
Query: 848 PPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLES 907
++ KT +A+ + + + + SA RLQE AG L +
Sbjct: 2753 TASQ--VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE-------AGILSA 2803
Query: 908 SETEEASQ---LKERLEKEKKLTSDLGRAATRLQELLKTTQEQLA 949
E + +Q + L + + + L ++ LLK T E+L+
Sbjct: 2804 EELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLS 2848
Score = 91.3 bits (225), Expect = 4e-18
Identities = 142/624 (22%), Positives = 248/624 (39%), Gaps = 69/624 (11%)
Query: 364 RLQQENSILRDALNQATSQVESKQNAE-LAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
RL + R+ + Q +++ E L K LS +++++ E R L
Sbjct: 1145 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1204
Query: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM 482
E E QV L A + E +L +S + TQ + LRA E+ +E Q
Sbjct: 1205 ELTLGKLE-QVRSLSAIYLE-------KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1256
Query: 483 AEL------HSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQA 536
A L + L+ A+ ++ L +L+ A+ +L +R + +E +
Sbjct: 1257 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1316
Query: 537 RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAME 596
R AQ ++ QA Q R +ELE L ++ RE+ + D R + +
Sbjct: 1317 RVAQLLERWQAVLAQTDVRQRELEQ----LGRQLRYYRESADPLGAWLQDARRRQEQIQA 1372
Query: 597 ALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDL 656
QA +E+L EE E+ +E Q+ +++ +
Sbjct: 1373 MPLADSQAVREQLRQEQALLEEIERHGEKVEE----------------CQRFAKQYINAI 1416
Query: 657 KEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSV 716
K+ L+ + A EP + A K + ++S +Q D R+ +E + K +
Sbjct: 1417 KDYELQLVTYK-AQLEPVASPAKKPKVQSGSESVIQEYVD-LRTHYSELTTLTSQYIKFI 1474
Query: 717 EEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHM 776
E T++ +EE E+ E + +++ RE + +EA LEK
Sbjct: 1475 SE---------------------TLRRMEE--EERLAEQQRAEE-RERLAEVEAALEKQR 1510
Query: 777 AAASAECQNYA---KEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVE 833
A A Q A +E L+Q + E + + A +AQ+Q + QQL +
Sbjct: 1511 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1570
Query: 834 DGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQ 893
A A+ E++ ++ QLE TE + + Q L A EEA+ + Q
Sbjct: 1571 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1630
Query: 894 EELEKLRTAGPLESSETEEAS-QLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAR-- 950
EE E+LR ES +A +L R++ E + + RA L+EL +E R
Sbjct: 1631 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1690
Query: 951 --EKDTVKKLQEQLEKAEDGSSSK 972
E + +++Q LE A+ + ++
Sbjct: 1691 QAEVERARQVQVALETAQRSAEAE 1714
Score = 76.3 bits (186), Expect = 1e-13
Identities = 119/582 (20%), Positives = 255/582 (43%), Gaps = 45/582 (7%)
Query: 143 EKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSK 202
++K +++ + + + L +A A +E V EA + ++ K
Sbjct: 2196 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2255
Query: 203 KKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDT-----WHKATQ 257
+ A + + E E + +E+A + Q K +
Sbjct: 2256 QSAEEQAQA------RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2309
Query: 258 KGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVA 317
+ K Q+E++ L + E+ K+ L E + + AE +AA ++V+++L +
Sbjct: 2310 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2369
Query: 318 ---REQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRD 374
+ +E++ ++AR++A R + ++ R LQE+ E ++ ++ +E + L
Sbjct: 2370 VRVQMEELSKLKARIEAENRALI--LRDKDNTQRFLQEEAE-----KMKQVAEEAARLSV 2422
Query: 375 ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVL 434
A +A +Q AE L Q+ + K L EK +AV+ E R EA+ +K++
Sbjct: 2423 AAQEAA---RLRQLAE-EDLAQQRALAEKMLKEKMQAVQ--EATRLKAEAELLQQQKELA 2476
Query: 435 QLQASH-RESEEALQKRLDEVSRELCHT----QSSHASLRADAEKAQEQQQQMAELHSKL 489
Q QA +E +E + ++L E ++ T + + A+AE+ + + +M+ ++
Sbjct: 2477 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2536
Query: 490 QSSEAEVRSKCEELSGLHGQLQEARAENSQL--TERIRSIEALLEAGQARDAQDVQASQA 547
+ R + EE+ + + A E L T I+ ++ +A + R+A +
Sbjct: 2537 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2596
Query: 548 EADQQQTRLKELESQ--VSGLEKEAIELREAVEQQKVKNND-LREKNWKAMEALATAEQA 604
E QQ+ +L +L+S+ + +++ ++ +A++Q + D L ++ + A EQ
Sbjct: 2597 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2656
Query: 605 CKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLL 664
++++ Q +EE ++Q +E Q + L+A + E A++ E + ++ K L
Sbjct: 2657 FQDEVAKAQQLREEQQRQQQQME-QERQRLVASMEE----ARRRQHEAEEGVRRKQEELQ 2711
Query: 665 KHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETE 706
+ + LA E + + LQ +Q+R+ LA +E
Sbjct: 2712 QLEQQRRQQEELLA---EENQRLREQLQLLEEQHRAALAHSE 2750
Score = 52.4 bits (124), Expect = 2e-06
Identities = 169/750 (22%), Positives = 280/750 (37%), Gaps = 152/750 (20%)
Query: 295 KEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKI------- 347
KEM +A +K Q + E + A Q ++ Y H +V++ GK+
Sbjct: 462 KEMELPAKEADKNRSKGIYQSL--EGAVQAGQLKVPPGY--HPLDVEKEWGKLHVAILER 517
Query: 348 -RTLQEQLENGPNTQ--LARLQQENSILRDALNQATSQVESKQNAELA-KLRQELSKVSK 403
+ L+ + E Q + +LQ E + + LNQA + ++S A K+ Q +V +
Sbjct: 518 EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVER 577
Query: 404 ELVEKSEAVR---------------QDEQQRKAL----EAKAAAFEKQVLQLQAS-HRES 443
+L + +R Q EQ + + E A + L+L+A +
Sbjct: 578 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 637
Query: 444 EEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM--AELHSKLQSSEAEVRSKCE 501
+ Q L V R S+ L+ +E Q ++ AE L S EA++ S
Sbjct: 638 TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH-- 695
Query: 502 ELSGLHGQLQEARAENSQLTERIRSIEALLEA---GQARDAQ---DVQASQAEADQQQTR 555
GLH ++E RA+ ER RS E L G RD D+Q ++ + + R
Sbjct: 696 --RGLHQSIEEFRAK----IERARSDEGQLSPATRGAYRDCLGRLDLQYAKL-LNSSKAR 748
Query: 556 LKELESQ---VSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSL 612
L+ LES V+ KE + L E E++ D ++N T A KE +L
Sbjct: 749 LRSLESLHSFVAAATKELMWLNEKEEEEV--GFDWSDRN--------TNMTAKKESYSAL 798
Query: 613 TQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLK--HPPAP 670
+ E EK++ ++L+ G LL+ HP P
Sbjct: 799 MRELELKEKKI------------------------------KELQNAGDRLLREDHPARP 828
Query: 671 AEPSSDLASKLREAEETQSTLQAECD--------QYRSILAETEGMLRDLQKSVEEEEQV 722
S A + + + Q E Q+ S + E EG L+ LQ+++ +
Sbjct: 829 TVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSC 888
Query: 723 WRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAE 782
R+ TV LE++++ + E E Q+ E+ HL ++ A +
Sbjct: 889 DRS-------------ATVTRLEDLLQDAQDEKE---QLNEYKGHLSGLAKRAKAVVQLK 932
Query: 783 CQNYAKEVAGLRQLLLESQSQLDAAKSEAQ-KQSDELALV-RQQLSEMKSHVEDGDIAGA 840
++ A + G LL + D + E + DE LV Q S K G A
Sbjct: 933 PRHPAHPMRGRLPLL----AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAV 988
Query: 841 PASSPEAPPAEQDP----------------------VQLKTQLEWTEAILEDEQTQRQKL 878
P+ PP Q+ V +K+ L W +++ D Q R
Sbjct: 989 PSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW-QSLRRDVQLIRSWS 1047
Query: 879 TAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQ 938
A F + R +L L S+ ++RL E++ S LQ
Sbjct: 1048 LATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQ 1107
Query: 939 ELLKTTQEQLAREK--DTVKKLQEQLEKAE 966
L + QE+ ++ +K ++ QLE E
Sbjct: 1108 SLEQGAQEESRCQRCISELKDIRLQLEACE 1137
Score = 37.7 bits (86), Expect = 0.053
Identities = 109/534 (20%), Positives = 200/534 (37%), Gaps = 48/534 (8%)
Query: 39 EEALANQR---KEMAKTHHQKVEK------------KKKEKTVEKKGKTKKKEEKPNGKI 83
EE LA QR ++M K Q V++ ++KE E+ + ++ +E+ ++
Sbjct: 2435 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2494
Query: 84 PDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKE 143
+ T+ E R + ++ + + VA ++ A +E K ++
Sbjct: 2495 AEETQGFQRTL---EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2551
Query: 144 KKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKK 203
+K+ + E A V +Q L + + + R E K + AK +
Sbjct: 2552 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2611
Query: 204 KGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGI---IQDTWHKATQKGD 260
+ L + L + S + + +R IE EKA + QD KA Q +
Sbjct: 2612 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE--QEKAKLEQLFQDEVAKAQQLRE 2669
Query: 261 PVAILKRQLEEKEKLLATEQEDAA----VAKSKLRELNKEM-AAEKAKAAAGEAKVKKQL 315
++Q+E++ + L E+A A+ +R +E+ E+ + E ++
Sbjct: 2670 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2729
Query: 316 VAREQ-EITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRD 374
REQ ++ Q R ++ E V Q K +GP + + + R
Sbjct: 2730 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRK 2789
Query: 375 ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVL 434
Q + EL +L Q + V + + + E VR Q R ++ + L
Sbjct: 2790 VSAQRLQEAGILSAEELQRLAQGHTTVDE--LARREDVRHYLQGRSSIAGLLLKATNEKL 2847
Query: 435 QLQASHRESEEALQKRLDEVSRELCHTQSSHAS---------LRADAEKAQEQQQQMAEL 485
+ A ALQ++L L ++ AS R +A ++ EL
Sbjct: 2848 SVYA-------ALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPEL 2900
Query: 486 HSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTER-IRSIEALLEAGQARD 538
H KL S+E V + +G L +A + + E IR +EA + G D
Sbjct: 2901 HHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVID 2954
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 132 bits (333), Expect = 1e-30
Identities = 221/1001 (22%), Positives = 413/1001 (41%), Gaps = 150/1001 (14%)
Query: 40 EALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREP 99
E A +++E+A+ Q++EK+++ + + ++E + +L E
Sbjct: 1658 EEQAVRQRELAE---QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1714
Query: 100 VRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNS 159
R A A T + + A +A V A + LAS + +++ K + + +
Sbjct: 1715 ARLQREAAAATQKRQEL-EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1773
Query: 160 IQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKT 219
+ L +AA L +E + +A +Q A A++ K +A T
Sbjct: 1774 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA---------T 1824
Query: 220 LVSTVGSMVFNEGEAQ--RLIEILSEKAGII-----QDTWHKAT---------------- 256
+ T + E EA+ RL + ++A Q HKA
Sbjct: 1825 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1884
Query: 257 --QKG--DPVAILKRQLEEKEKLLATEQEDAAVAKSKL-----------------RELNK 295
QKG + +RQ+EE+ L E AA K++L +E +
Sbjct: 1885 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1944
Query: 296 EMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKI---RTLQE 352
AA + + AA E + +++ R Q+ A + + ++EV++L+ K+ R L+E
Sbjct: 1945 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2004
Query: 353 QLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAV 412
+ E QL Q+ A +A + ++ EL + Q+ V +L ++EA
Sbjct: 2005 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2064
Query: 413 R----QDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDE--VSRELCHTQSSHA 466
R + E+ R E +AA +QV + + + +EE Q R + +L A
Sbjct: 2065 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124
Query: 467 SLRADAEKAQEQQQQMA--ELHSKLQSSEAEVRSKCE---ELSGLHGQLQEARAENSQLT 521
+ RA AE+A +Q+Q A E+ + +E +R K + EL+ L QL+E + + L
Sbjct: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184
Query: 522 ERIRSIEALLEAGQA-RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQ 580
E ++ ++A EA +A R V+ Q L +L++++ E A+ LR+ Q
Sbjct: 2185 EELQRLKA--EATEAARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQ 2241
Query: 581 KVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPE 640
+ + EK + E A A +E A+E+ +Q L E E + A+
Sbjct: 2242 RFLQEEA-EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2300
Query: 641 LSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQS---TLQAECDQ 697
+ A+ + ++L ++ L+ E +A +L AEETQ TL+AE +
Sbjct: 2301 TRLKAEAELLQQQKELAQEQARRLQ------EDKEQMAQQL--AEETQGFQRTLEAERQR 2352
Query: 698 YRSILAETEGM------LRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKL 751
+ AE E + + Q EE+ Q +R + E+L ++ + + +V+ L
Sbjct: 2353 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2412
Query: 752 KGELESSD----QVREHTSHLEAELEK-HMAAASAECQNYAKEVAGLRQLLLESQSQLDA 806
+ + + SD ++RE + LE E EK A + ++ + QLL E+Q+ +
Sbjct: 2413 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2472
Query: 807 AKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEA 866
SE + Q+ ++++ +D ++A A QL+ + + +
Sbjct: 2473 FLSEKDSLLQRERFIEQEKAKLEQLFQD-EVAKAQ--------------QLREEQQRQQQ 2517
Query: 867 ILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKL 926
+E E RQ+L A EEA+ +E + + + EE QL+++
Sbjct: 2518 QMEQE---RQRLVASMEEARRRQHEAEEGVRR----------KQEELQQLEQQ------- 2557
Query: 927 TSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAED 967
+ QE+L E++ ++L+EQL+ E+
Sbjct: 2558 ---------------RRQQEELLAEEN--QRLREQLQLLEE 2581
Score = 131 bits (329), Expect = 4e-30
Identities = 191/766 (24%), Positives = 334/766 (43%), Gaps = 108/766 (14%)
Query: 267 RQLEEKEKLL----ATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEI 322
R++EE+E+L A E+E A ++ L E +++A A+A A + K+L R QE
Sbjct: 1320 RRMEEEERLAEQQRAEERERLAEVEAAL-EKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1378
Query: 323 T------AVQARMQA-SYREHVKEVQQL-QGKIRTLQEQLENGPNTQLARLQQENSILRD 374
AV A+ Q S +E +++++Q + +I+ Q E ++L R+++E ++R
Sbjct: 1379 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVVRL 1437
Query: 375 ALNQATSQVESKQNAELAKLR---QELSKVSKELVEKSEAVR---QDEQQRKA------- 421
L +AT + EL LR +E ++ E++E +R QDE QRK
Sbjct: 1438 QL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1496
Query: 422 ----LEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHT---------QSSHASL 468
EA+AA +++ LQ R E ++RL + E +S+ A L
Sbjct: 1497 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1556
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTER--IRS 526
++ E+ Q+ + + A++R + E + + + AR E + ER +++
Sbjct: 1557 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1616
Query: 527 IEALLEAGQARD-AQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNN 585
EAL QA + AQ +QAEA++Q+ + + E++A+ RE EQ+ K
Sbjct: 1617 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1676
Query: 586 DLREKNWKAMEALATAEQ--ACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSV 643
L E TA+Q A +++L L E+ E+Q L+E + LA L +
Sbjct: 1677 QLAE---------GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAA 1722
Query: 644 LAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQST-------LQAECD 696
A Q E +L + AE LASK R EE++ST L+AE
Sbjct: 1723 AATQKRQELEAELAK----------VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1772
Query: 697 QYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELE 756
++R LAE LR L + + + Q+ A+ AA + + RV + L I E + + E
Sbjct: 1773 RFRE-LAEEAARLRALAEEAKRQRQL--AEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1829
Query: 757 SSDQVREHTSHLEAELEKHMAAASAEC-----------QNYAKEVAGLRQLLLESQSQLD 805
+ ++E EAE E+ A E Q+ A L QL S S+L+
Sbjct: 1830 AEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1885
Query: 806 AAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSP--EAPPAEQDPVQLKTQLEW 863
K + + V +++ +K+ E A +D ++ K Q E
Sbjct: 1886 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1945
Query: 864 TEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKE 923
A + ++ E EE + +EE + R A EE +LK ++E+
Sbjct: 1946 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA------LEEVERLKAKVEEA 1999
Query: 924 KKLTSDLGR-AATRLQELLKTTQEQLAREKD----TVKKLQEQLEK 964
++L + +A +LQ + Q++L E+ V++ +++L++
Sbjct: 2000 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2045
Score = 125 bits (313), Expect = 3e-28
Identities = 182/812 (22%), Positives = 335/812 (41%), Gaps = 111/812 (13%)
Query: 231 EGEAQRLIEILSEKA--GIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKS 288
E E R +++ E A + K + A L+R L+E+ +A +E+A
Sbjct: 1534 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE---- 1589
Query: 289 KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIR 348
R ++ AE+A+ A + QL A E A++ R+QA K + Q +
Sbjct: 1590 --RRAQQQAEAERAREEAERELERWQLKANE----ALRLRLQAEEVAQQKSLAQAEA--- 1640
Query: 349 TLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEK 408
++Q E R + E +R A ++E ++ +Q L+ +EL+
Sbjct: 1641 --EKQKEEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLAEGTAQQRLA-AEQELIRL 1696
Query: 409 SEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASL 468
Q EQQR+ LE + A +++ +E E L K E+ L +
Sbjct: 1697 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1756
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERI--RS 526
R+ +EK++++ + A +L A +R+ EE +E A ER+
Sbjct: 1757 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1816
Query: 527 IEALLEAGQARDAQDVQASQAEADQ------------QQTRLKELESQ-VSGLEKEAIEL 573
+ A+ EA + + ++ + EA+ Q+ RL+E +Q + +E+ +L
Sbjct: 1817 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1876
Query: 574 REAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEA 633
R+A + + + L E + + A K K E E +L I + +
Sbjct: 1877 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1936
Query: 634 LLAL-LPELSVLAQ-QNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTL 691
L + EL Q Q E + +E + K A E + + L E E ++ +
Sbjct: 1937 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1996
Query: 692 Q--------AECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKH 743
+ AE + R + E QK ++ EE+ V E+ELQ+ T++
Sbjct: 1997 EEARRLRERAEQESARQLQLAQEA----AQKRLQAEEKAHAFAVQQKEQELQQ---TLQQ 2049
Query: 744 LEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAA------------SAECQNYAKEVA 791
+ ++++L+GE E++ + E + E+ A + SAE Q A+ A
Sbjct: 2050 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2109
Query: 792 GLRQLLLESQSQLDAAKSEAQKQSDELALVRQQL--SEMKSHVEDGDIAGAPASSPEAPP 849
L +++ +AA+ + Q+++ AL ++Q +EM+ H + A + +
Sbjct: 2110 QAAAEKLRKEAEQEAAR---RAQAEQAALRQKQAADAEMEKHKK-----FAEQTLRQKAQ 2161
Query: 850 AEQDPVQLKTQLEWT--EAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLES 907
EQ+ L+ QLE T + L DE+ QR L AE EA +++EEL +R
Sbjct: 2162 VEQELTTLRLQLEETDHQKNLLDEELQR--LKAEATEAARQRSQVEEELFSVRV------ 2213
Query: 908 SETEEASQLKERLEKE-----------------------KKLTSDLGRAATRLQE---LL 941
+ EE S+LK R+E E K++ + R + QE L
Sbjct: 2214 -QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2272
Query: 942 KTTQEQLAREKDTVKK-LQEQLEKAEDGSSSK 972
+ +E LA+++ +K L+E+++ ++ + K
Sbjct: 2273 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2304
Score = 120 bits (302), Expect = 5e-27
Identities = 226/1009 (22%), Positives = 419/1009 (41%), Gaps = 122/1009 (12%)
Query: 35 ETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKK--EEKPNGKIPDHDPAPNV 92
E +E ++E+ + V+ ++++++++++ + ++ E + K + A
Sbjct: 1365 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1424
Query: 93 TVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPA 152
+ + E +R + + T Q + + A +E A + +++ E+ +V+
Sbjct: 1425 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484
Query: 153 VSSVVNSIQVLTSKA-AILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADG 211
+ L S+ A E A ++ R + +EA + + ++
Sbjct: 1485 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQV 1543
Query: 212 PLYLPYKTLVSTVGSM--VFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQL 269
L ++ + + S F E AQ L L E+ + +A ++ A +R
Sbjct: 1544 ALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1602
Query: 270 EEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
EE E+ L Q A A +LR +E+A +K+ A A EA+ +K+ RE AR
Sbjct: 1603 EEAERELERWQLKANEAL-RLRLQAEEVAQQKSLAQA-EAEKQKEEAERE-------ARR 1653
Query: 330 QASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNA 389
+ E ++L + Q QL G Q +QE LR Q Q + +
Sbjct: 1654 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE- 1712
Query: 390 ELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQK 449
ELA+L++E + +++ E + + + + L A A E++ ++ EA
Sbjct: 1713 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1772
Query: 450 RLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQ 509
R E++ E A LRA AE+A+ +Q+Q+AE + Q +EAE R E+L+ +
Sbjct: 1773 RFRELAEEA-------ARLRALAEEAK-RQRQLAEEDAARQRAEAE-RVLAEKLAAIGEA 1823
Query: 510 ----------LQEARAENSQLTERIRSIEAL----LEAGQARDAQDVQ--------ASQA 547
L+E AEN +L R+ EA LE A+ D++ AS +
Sbjct: 1824 TRLKTEAEIALKEKEAENERL-RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1882
Query: 548 EADQQQTRLKELESQVSGLEKEAIELREAVEQQ------------KVKNN---DLREKNW 592
E ++Q+ +++ Q +E+E + L+ + E+ ++++N LR K
Sbjct: 1883 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1942
Query: 593 KAMEA-----LATAEQA----CKEKLHSLTQAKEESEKQ--LCLIEAQTMEALLALLPEL 641
+EA LA E+ +E++ A+EE+ +Q L E + ++A + L
Sbjct: 1943 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2002
Query: 642 SVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSI 701
A+Q LQ +E L+ AE + + ++ +E Q TLQ E +S+
Sbjct: 2003 RERAEQESARQLQLAQEAAQKRLQ-----AEEKAHAFAVQQKEQELQQTLQQE----QSV 2053
Query: 702 LAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQV 761
L + G +++ EE E+ A+V A E Q R E E+LK E Q
Sbjct: 2054 LDQLRGEAEAARRAAEEAEE---ARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQA 2105
Query: 762 REHTSHLEAELEKHMAAASAECQNYAK-EVAGLRQLLLESQSQLDAAKSEAQKQSDELAL 820
R + +A EK A E A+ E A LRQ + ++++ K A++ + A
Sbjct: 2106 R---AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAEQTLRQKAQ 2161
Query: 821 VRQQLSEMKSHVEDGDIAG------APASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQ 874
V Q+L+ ++ +E+ D EA A + Q++ +L +E+
Sbjct: 2162 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2221
Query: 875 RQKLTAE-----FEEAQTSACRLQEELEKLRT--------------AGPLESSETEEASQ 915
+ ++ AE + + LQEE EK++ A L E+ +Q
Sbjct: 2222 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2281
Query: 916 LKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEK 964
+ EK K + ATRL+ + Q+Q ++ ++LQE E+
Sbjct: 2282 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2330
Score = 113 bits (283), Expect = 8e-25
Identities = 192/851 (22%), Positives = 366/851 (43%), Gaps = 106/851 (12%)
Query: 183 AQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLV---STVGSMVFNE-GEAQRLI 238
AQ+ A E A K S K + +A P + + + VG + GE +
Sbjct: 1093 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1152
Query: 239 EILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMA 298
E E+ + + W + D + +R+LE+ + L +E A + L++ +
Sbjct: 1153 ERWRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1209
Query: 299 AEKAKAAAGEAKVKKQLVAREQEITAVQAR------MQASYREHVKEVQQLQGKIRTLQE 352
+A A V++QL + + ++ Q ++++ ++ + ++ T +
Sbjct: 1210 QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1269
Query: 353 QLEN--GPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSE 410
QLE P + S++++ ++ T +EL L + K E + + E
Sbjct: 1270 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHY------SELTTLTSQYIKFISETLRRME 1323
Query: 411 -----AVRQDEQQRKALEAKAAAFEKQVLQLQASH--------RESEEALQKRLDEVSRE 457
A +Q ++R+ L AA EKQ QL +H RE++E Q+ +EV R
Sbjct: 1324 EEERLAEQQRAEERERLAEVEAALEKQ-RQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1382
Query: 458 LCHTQSSHASLRADAEKAQE-QQQQMAELHSKLQSSEAEVRSKC---EEL---------- 503
+ R+ E+ Q+ +Q AE+ +K + +EA RS+ EE+
Sbjct: 1383 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1442
Query: 504 ----SGLHGQLQ--EARAENSQLTERIRSIEALL-------EAGQARDAQDVQASQAEAD 550
G G+LQ ARAE ++ +R EA E+ + R A+ AS+ +A+
Sbjct: 1443 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1502
Query: 551 QQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLH 610
+ R E + + LE+ ++ EA +++++ ++ E+ + AL TA+++ + +L
Sbjct: 1503 AEAAR--EKQRALQALEELRLQAEEA--ERRLRQAEV-ERARQVQVALETAQRSAEAELQ 1557
Query: 611 SLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAP 670
S + E QL + A+ L E AQQ + +E+ L+
Sbjct: 1558 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE--AERAREEAERELERWQLK 1615
Query: 671 AEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAA 730
A + L + E + +S QAE ++ + E R+ ++ + EEQ R + A
Sbjct: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEK------QKEEAEREARRRGKAEEQAVRQR-ELA 1668
Query: 731 EEELQKSRVTVK-------HLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAEC 783
E+EL+K R + E+ + +L+ E E +Q R+ A L++ AAA+ +
Sbjct: 1669 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728
Query: 784 QNYAKEVAGLR---QLLLESQSQLD---AAKSEAQKQSDELALVR-QQLSEMKSHVEDGD 836
Q E+A +R ++LL S+++ + + SE KQ E R ++L+E + +
Sbjct: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR--- 1785
Query: 837 IAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEEL 896
A A + + AE+D + + + E +L ++ + T EA+ + + E
Sbjct: 1786 -ALAEEAKRQRQLAEEDAARQRAE---AERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1841
Query: 897 EKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVK 956
E+LR L E + +L+E+ + K +D+ RL +L K + +L R+K V+
Sbjct: 1842 ERLRR---LAEDEAFQRRRLEEQAAQHK---ADI---EERLAQLRKASDSELERQKGLVE 1892
Query: 957 KLQEQLEKAED 967
Q + E+
Sbjct: 1893 DTLRQRRQVEE 1903
Score = 111 bits (278), Expect = 3e-24
Identities = 176/765 (23%), Positives = 322/765 (42%), Gaps = 117/765 (15%)
Query: 266 KRQLEEK-EKLLATEQEDAAVAKSKLRELNKEMA----AEKAKAAAGEAKVKKQLVAREQ 320
+R+ EE+ +K LA E+E A K+ L E+ + A A + + A + ++ +A+E
Sbjct: 1961 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE- 2019
Query: 321 EITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQAT 380
A Q R+QA + H VQQ K + LQ+ L QQE S+L +A
Sbjct: 2020 ---AAQKRLQAEEKAHAFAVQQ---KEQELQQTL-----------QQEQSVLDQLRGEAE 2062
Query: 381 SQVESKQNAELAKLRQELSKV-SKELVEKSEAVRQ--DEQQRKALEAKAAA--FEKQVLQ 435
+ + + AE A+++ E S+ VE++E ++Q +EQ + +A+AAA K+ Q
Sbjct: 2063 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2122
Query: 436 LQASHRESEEALQKRLDEVSREL-CHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEA 494
A ++E+A ++ E+ H + + +LR +KAQ +Q+ + L +L+ ++
Sbjct: 2123 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR---QKAQVEQE-LTTLRLQLEETDH 2178
Query: 495 EVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLE--------------AGQARDAQ 540
+ EEL L + EA + SQ+ E + S+ +E A RD
Sbjct: 2179 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2238
Query: 541 DVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAM----- 595
+ Q E ++ ++ E +++S +EA LR+ E+ + L EK K
Sbjct: 2239 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2298
Query: 596 ---------EALATAEQACKEKLHSLTQAKEESEKQLC--------------------LI 626
E L ++ +E+ L + KE+ +QL
Sbjct: 2299 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2358
Query: 627 EAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEE 686
EA+ ++ +A + A+++ + + +E G L + A E + L L E +
Sbjct: 2359 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTL-EIQR 2416
Query: 687 TQSTLQAECDQYRSILAETEGMLRDLQKSV-------EEEEQVWRAKVGAAEEELQKSRV 739
QS AE + R +AE E LQ+ EE + V + ++ + LQ+S +
Sbjct: 2417 QQSDHDAE--RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474
Query: 740 TVK----HLEEIVEKLKGELES--------SDQVREHTSHLEAELEKHMAAASAECQNYA 787
+ K E +E+ K +LE + Q+RE + ++E+ A +
Sbjct: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2534
Query: 788 KEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEA 847
+ + + Q +L + + ++Q + LA Q+L E +E+ A A A S E
Sbjct: 2535 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA-ALAHSEEV 2593
Query: 848 PPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLES 907
++ KT +A+ + + + + SA RLQE AG L +
Sbjct: 2594 TASQ--VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE-------AGILSA 2644
Query: 908 SETEEASQ---LKERLEKEKKLTSDLGRAATRLQELLKTTQEQLA 949
E + +Q + L + + + L ++ LLK T E+L+
Sbjct: 2645 EELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLS 2689
Score = 91.3 bits (225), Expect = 4e-18
Identities = 142/624 (22%), Positives = 248/624 (39%), Gaps = 69/624 (11%)
Query: 364 RLQQENSILRDALNQATSQVESKQNAE-LAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
RL + R+ + Q +++ E L K LS +++++ E R L
Sbjct: 986 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1045
Query: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM 482
E E QV L A + E +L +S + TQ + LRA E+ +E Q
Sbjct: 1046 ELTLGKLE-QVRSLSAIYLE-------KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1097
Query: 483 AEL------HSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQA 536
A L + L+ A+ ++ L +L+ A+ +L +R + +E +
Sbjct: 1098 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1157
Query: 537 RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAME 596
R AQ ++ QA Q R +ELE L ++ RE+ + D R + +
Sbjct: 1158 RVAQLLERWQAVLAQTDVRQRELEQ----LGRQLRYYRESADPLGAWLQDARRRQEQIQA 1213
Query: 597 ALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDL 656
QA +E+L EE E+ +E Q+ +++ +
Sbjct: 1214 MPLADSQAVREQLRQEQALLEEIERHGEKVEE----------------CQRFAKQYINAI 1257
Query: 657 KEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSV 716
K+ L+ + A EP + A K + ++S +Q D R+ +E + K +
Sbjct: 1258 KDYELQLVTYK-AQLEPVASPAKKPKVQSGSESVIQEYVD-LRTHYSELTTLTSQYIKFI 1315
Query: 717 EEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHM 776
E T++ +EE E+ E + +++ RE + +EA LEK
Sbjct: 1316 SE---------------------TLRRMEE--EERLAEQQRAEE-RERLAEVEAALEKQR 1351
Query: 777 AAASAECQNYA---KEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVE 833
A A Q A +E L+Q + E + + A +AQ+Q + QQL +
Sbjct: 1352 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1411
Query: 834 DGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQ 893
A A+ E++ ++ QLE TE + + Q L A EEA+ + Q
Sbjct: 1412 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1471
Query: 894 EELEKLRTAGPLESSETEEAS-QLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAR-- 950
EE E+LR ES +A +L R++ E + + RA L+EL +E R
Sbjct: 1472 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1531
Query: 951 --EKDTVKKLQEQLEKAEDGSSSK 972
E + +++Q LE A+ + ++
Sbjct: 1532 QAEVERARQVQVALETAQRSAEAE 1555
Score = 76.3 bits (186), Expect = 1e-13
Identities = 119/582 (20%), Positives = 255/582 (43%), Gaps = 45/582 (7%)
Query: 143 EKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSK 202
++K +++ + + + L +A A +E V EA + ++ K
Sbjct: 2037 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2096
Query: 203 KKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDT-----WHKATQ 257
+ A + + E E + +E+A + Q K +
Sbjct: 2097 QSAEEQAQA------RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2150
Query: 258 KGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVA 317
+ K Q+E++ L + E+ K+ L E + + AE +AA ++V+++L +
Sbjct: 2151 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2210
Query: 318 ---REQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRD 374
+ +E++ ++AR++A R + ++ R LQE+ E ++ ++ +E + L
Sbjct: 2211 VRVQMEELSKLKARIEAENRALI--LRDKDNTQRFLQEEAE-----KMKQVAEEAARLSV 2263
Query: 375 ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVL 434
A +A +Q AE L Q+ + K L EK +AV+ E R EA+ +K++
Sbjct: 2264 AAQEAA---RLRQLAE-EDLAQQRALAEKMLKEKMQAVQ--EATRLKAEAELLQQQKELA 2317
Query: 435 QLQASH-RESEEALQKRLDEVSRELCHT----QSSHASLRADAEKAQEQQQQMAELHSKL 489
Q QA +E +E + ++L E ++ T + + A+AE+ + + +M+ ++
Sbjct: 2318 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2377
Query: 490 QSSEAEVRSKCEELSGLHGQLQEARAENSQL--TERIRSIEALLEAGQARDAQDVQASQA 547
+ R + EE+ + + A E L T I+ ++ +A + R+A +
Sbjct: 2378 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2437
Query: 548 EADQQQTRLKELESQ--VSGLEKEAIELREAVEQQKVKNND-LREKNWKAMEALATAEQA 604
E QQ+ +L +L+S+ + +++ ++ +A++Q + D L ++ + A EQ
Sbjct: 2438 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2497
Query: 605 CKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLL 664
++++ Q +EE ++Q +E Q + L+A + E A++ E + ++ K L
Sbjct: 2498 FQDEVAKAQQLREEQQRQQQQME-QERQRLVASMEE----ARRRQHEAEEGVRRKQEELQ 2552
Query: 665 KHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETE 706
+ + LA E + + LQ +Q+R+ LA +E
Sbjct: 2553 QLEQQRRQQEELLA---EENQRLREQLQLLEEQHRAALAHSE 2591
Score = 52.4 bits (124), Expect = 2e-06
Identities = 169/750 (22%), Positives = 280/750 (37%), Gaps = 152/750 (20%)
Query: 295 KEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKI------- 347
KEM +A +K Q + E + A Q ++ Y H +V++ GK+
Sbjct: 303 KEMELPAKEADKNRSKGIYQSL--EGAVQAGQLKVPPGY--HPLDVEKEWGKLHVAILER 358
Query: 348 -RTLQEQLENGPNTQ--LARLQQENSILRDALNQATSQVESKQNAELA-KLRQELSKVSK 403
+ L+ + E Q + +LQ E + + LNQA + ++S A K+ Q +V +
Sbjct: 359 EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVER 418
Query: 404 ELVEKSEAVR---------------QDEQQRKAL----EAKAAAFEKQVLQLQAS-HRES 443
+L + +R Q EQ + + E A + L+L+A +
Sbjct: 419 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 478
Query: 444 EEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM--AELHSKLQSSEAEVRSKCE 501
+ Q L V R S+ L+ +E Q ++ AE L S EA++ S
Sbjct: 479 TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH-- 536
Query: 502 ELSGLHGQLQEARAENSQLTERIRSIEALLEA---GQARDAQ---DVQASQAEADQQQTR 555
GLH ++E RA+ ER RS E L G RD D+Q ++ + + R
Sbjct: 537 --RGLHQSIEEFRAK----IERARSDEGQLSPATRGAYRDCLGRLDLQYAKL-LNSSKAR 589
Query: 556 LKELESQ---VSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSL 612
L+ LES V+ KE + L E E++ D ++N T A KE +L
Sbjct: 590 LRSLESLHSFVAAATKELMWLNEKEEEEV--GFDWSDRN--------TNMTAKKESYSAL 639
Query: 613 TQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLK--HPPAP 670
+ E EK++ ++L+ G LL+ HP P
Sbjct: 640 MRELELKEKKI------------------------------KELQNAGDRLLREDHPARP 669
Query: 671 AEPSSDLASKLREAEETQSTLQAECD--------QYRSILAETEGMLRDLQKSVEEEEQV 722
S A + + + Q E Q+ S + E EG L+ LQ+++ +
Sbjct: 670 TVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSC 729
Query: 723 WRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAE 782
R+ TV LE++++ + E E Q+ E+ HL ++ A +
Sbjct: 730 DRS-------------ATVTRLEDLLQDAQDEKE---QLNEYKGHLSGLAKRAKAVVQLK 773
Query: 783 CQNYAKEVAGLRQLLLESQSQLDAAKSEAQ-KQSDELALV-RQQLSEMKSHVEDGDIAGA 840
++ A + G LL + D + E + DE LV Q S K G A
Sbjct: 774 PRHPAHPMRGRLPLL----AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAV 829
Query: 841 PASSPEAPPAEQDP----------------------VQLKTQLEWTEAILEDEQTQRQKL 878
P+ PP Q+ V +K+ L W +++ D Q R
Sbjct: 830 PSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW-QSLRRDVQLIRSWS 888
Query: 879 TAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQ 938
A F + R +L L S+ ++RL E++ S LQ
Sbjct: 889 LATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQ 948
Query: 939 ELLKTTQEQLAREK--DTVKKLQEQLEKAE 966
L + QE+ ++ +K ++ QLE E
Sbjct: 949 SLEQGAQEESRCQRCISELKDIRLQLEACE 978
Score = 37.7 bits (86), Expect = 0.053
Identities = 109/534 (20%), Positives = 200/534 (37%), Gaps = 48/534 (8%)
Query: 39 EEALANQR---KEMAKTHHQKVEK------------KKKEKTVEKKGKTKKKEEKPNGKI 83
EE LA QR ++M K Q V++ ++KE E+ + ++ +E+ ++
Sbjct: 2276 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2335
Query: 84 PDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKE 143
+ T+ E R + ++ + + VA ++ A +E K ++
Sbjct: 2336 AEETQGFQRTL---EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2392
Query: 144 KKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKK 203
+K+ + E A V +Q L + + + R E K + AK +
Sbjct: 2393 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2452
Query: 204 KGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGI---IQDTWHKATQKGD 260
+ L + L + S + + +R IE EKA + QD KA Q +
Sbjct: 2453 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE--QEKAKLEQLFQDEVAKAQQLRE 2510
Query: 261 PVAILKRQLEEKEKLLATEQEDAA----VAKSKLRELNKEM-AAEKAKAAAGEAKVKKQL 315
++Q+E++ + L E+A A+ +R +E+ E+ + E ++
Sbjct: 2511 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2570
Query: 316 VAREQ-EITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRD 374
REQ ++ Q R ++ E V Q K +GP + + + R
Sbjct: 2571 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRK 2630
Query: 375 ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVL 434
Q + EL +L Q + V + + + E VR Q R ++ + L
Sbjct: 2631 VSAQRLQEAGILSAEELQRLAQGHTTVDE--LARREDVRHYLQGRSSIAGLLLKATNEKL 2688
Query: 435 QLQASHRESEEALQKRLDEVSRELCHTQSSHAS---------LRADAEKAQEQQQQMAEL 485
+ A ALQ++L L ++ AS R +A ++ EL
Sbjct: 2689 SVYA-------ALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPEL 2741
Query: 486 HSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTER-IRSIEALLEAGQARD 538
H KL S+E V + +G L +A + + E IR +EA + G D
Sbjct: 2742 HHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVID 2795
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 132 bits (333), Expect = 1e-30
Identities = 221/1001 (22%), Positives = 413/1001 (41%), Gaps = 150/1001 (14%)
Query: 40 EALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREP 99
E A +++E+A+ Q++EK+++ + + ++E + +L E
Sbjct: 1666 EEQAVRQRELAE---QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1722
Query: 100 VRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNS 159
R A A T + + A +A V A + LAS + +++ K + + +
Sbjct: 1723 ARLQREAAAATQKRQEL-EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1781
Query: 160 IQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKT 219
+ L +AA L +E + +A +Q A A++ K +A T
Sbjct: 1782 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA---------T 1832
Query: 220 LVSTVGSMVFNEGEAQ--RLIEILSEKAGII-----QDTWHKAT---------------- 256
+ T + E EA+ RL + ++A Q HKA
Sbjct: 1833 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1892
Query: 257 --QKG--DPVAILKRQLEEKEKLLATEQEDAAVAKSKL-----------------RELNK 295
QKG + +RQ+EE+ L E AA K++L +E +
Sbjct: 1893 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1952
Query: 296 EMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKI---RTLQE 352
AA + + AA E + +++ R Q+ A + + ++EV++L+ K+ R L+E
Sbjct: 1953 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2012
Query: 353 QLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAV 412
+ E QL Q+ A +A + ++ EL + Q+ V +L ++EA
Sbjct: 2013 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2072
Query: 413 R----QDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDE--VSRELCHTQSSHA 466
R + E+ R E +AA +QV + + + +EE Q R + +L A
Sbjct: 2073 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2132
Query: 467 SLRADAEKAQEQQQQMA--ELHSKLQSSEAEVRSKCE---ELSGLHGQLQEARAENSQLT 521
+ RA AE+A +Q+Q A E+ + +E +R K + EL+ L QL+E + + L
Sbjct: 2133 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2192
Query: 522 ERIRSIEALLEAGQA-RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQ 580
E ++ ++A EA +A R V+ Q L +L++++ E A+ LR+ Q
Sbjct: 2193 EELQRLKA--EATEAARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQ 2249
Query: 581 KVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPE 640
+ + EK + E A A +E A+E+ +Q L E E + A+
Sbjct: 2250 RFLQEEA-EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2308
Query: 641 LSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQS---TLQAECDQ 697
+ A+ + ++L ++ L+ E +A +L AEETQ TL+AE +
Sbjct: 2309 TRLKAEAELLQQQKELAQEQARRLQ------EDKEQMAQQL--AEETQGFQRTLEAERQR 2360
Query: 698 YRSILAETEGM------LRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKL 751
+ AE E + + Q EE+ Q +R + E+L ++ + + +V+ L
Sbjct: 2361 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2420
Query: 752 KGELESSD----QVREHTSHLEAELEK-HMAAASAECQNYAKEVAGLRQLLLESQSQLDA 806
+ + + SD ++RE + LE E EK A + ++ + QLL E+Q+ +
Sbjct: 2421 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2480
Query: 807 AKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEA 866
SE + Q+ ++++ +D ++A A QL+ + + +
Sbjct: 2481 FLSEKDSLLQRERFIEQEKAKLEQLFQD-EVAKAQ--------------QLREEQQRQQQ 2525
Query: 867 ILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKL 926
+E E RQ+L A EEA+ +E + + + EE QL+++
Sbjct: 2526 QMEQE---RQRLVASMEEARRRQHEAEEGVRR----------KQEELQQLEQQ------- 2565
Query: 927 TSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAED 967
+ QE+L E++ ++L+EQL+ E+
Sbjct: 2566 ---------------RRQQEELLAEEN--QRLREQLQLLEE 2589
Score = 131 bits (329), Expect = 4e-30
Identities = 191/766 (24%), Positives = 334/766 (43%), Gaps = 108/766 (14%)
Query: 267 RQLEEKEKLL----ATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEI 322
R++EE+E+L A E+E A ++ L E +++A A+A A + K+L R QE
Sbjct: 1328 RRMEEEERLAEQQRAEERERLAEVEAAL-EKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1386
Query: 323 T------AVQARMQA-SYREHVKEVQQL-QGKIRTLQEQLENGPNTQLARLQQENSILRD 374
AV A+ Q S +E +++++Q + +I+ Q E ++L R+++E ++R
Sbjct: 1387 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVVRL 1445
Query: 375 ALNQATSQVESKQNAELAKLR---QELSKVSKELVEKSEAVR---QDEQQRKA------- 421
L +AT + EL LR +E ++ E++E +R QDE QRK
Sbjct: 1446 QL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1504
Query: 422 ----LEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHT---------QSSHASL 468
EA+AA +++ LQ R E ++RL + E +S+ A L
Sbjct: 1505 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1564
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTER--IRS 526
++ E+ Q+ + + A++R + E + + + AR E + ER +++
Sbjct: 1565 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1624
Query: 527 IEALLEAGQARD-AQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNN 585
EAL QA + AQ +QAEA++Q+ + + E++A+ RE EQ+ K
Sbjct: 1625 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1684
Query: 586 DLREKNWKAMEALATAEQ--ACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSV 643
L E TA+Q A +++L L E+ E+Q L+E + LA L +
Sbjct: 1685 QLAE---------GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAA 1730
Query: 644 LAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQST-------LQAECD 696
A Q E +L + AE LASK R EE++ST L+AE
Sbjct: 1731 AATQKRQELEAELAK----------VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1780
Query: 697 QYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELE 756
++R LAE LR L + + + Q+ A+ AA + + RV + L I E + + E
Sbjct: 1781 RFRE-LAEEAARLRALAEEAKRQRQL--AEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1837
Query: 757 SSDQVREHTSHLEAELEKHMAAASAEC-----------QNYAKEVAGLRQLLLESQSQLD 805
+ ++E EAE E+ A E Q+ A L QL S S+L+
Sbjct: 1838 AEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1893
Query: 806 AAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSP--EAPPAEQDPVQLKTQLEW 863
K + + V +++ +K+ E A +D ++ K Q E
Sbjct: 1894 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1953
Query: 864 TEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKE 923
A + ++ E EE + +EE + R A EE +LK ++E+
Sbjct: 1954 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA------LEEVERLKAKVEEA 2007
Query: 924 KKLTSDLGR-AATRLQELLKTTQEQLAREKD----TVKKLQEQLEK 964
++L + +A +LQ + Q++L E+ V++ +++L++
Sbjct: 2008 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2053
Score = 125 bits (313), Expect = 3e-28
Identities = 182/812 (22%), Positives = 335/812 (41%), Gaps = 111/812 (13%)
Query: 231 EGEAQRLIEILSEKA--GIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKS 288
E E R +++ E A + K + A L+R L+E+ +A +E+A
Sbjct: 1542 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE---- 1597
Query: 289 KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIR 348
R ++ AE+A+ A + QL A E A++ R+QA K + Q +
Sbjct: 1598 --RRAQQQAEAERAREEAERELERWQLKANE----ALRLRLQAEEVAQQKSLAQAEA--- 1648
Query: 349 TLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEK 408
++Q E R + E +R A ++E ++ +Q L+ +EL+
Sbjct: 1649 --EKQKEEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLAEGTAQQRLA-AEQELIRL 1704
Query: 409 SEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASL 468
Q EQQR+ LE + A +++ +E E L K E+ L +
Sbjct: 1705 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1764
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERI--RS 526
R+ +EK++++ + A +L A +R+ EE +E A ER+
Sbjct: 1765 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1824
Query: 527 IEALLEAGQARDAQDVQASQAEADQ------------QQTRLKELESQ-VSGLEKEAIEL 573
+ A+ EA + + ++ + EA+ Q+ RL+E +Q + +E+ +L
Sbjct: 1825 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1884
Query: 574 REAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEA 633
R+A + + + L E + + A K K E E +L I + +
Sbjct: 1885 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1944
Query: 634 LLAL-LPELSVLAQ-QNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTL 691
L + EL Q Q E + +E + K A E + + L E E ++ +
Sbjct: 1945 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2004
Query: 692 Q--------AECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKH 743
+ AE + R + E QK ++ EE+ V E+ELQ+ T++
Sbjct: 2005 EEARRLRERAEQESARQLQLAQEA----AQKRLQAEEKAHAFAVQQKEQELQQ---TLQQ 2057
Query: 744 LEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAA------------SAECQNYAKEVA 791
+ ++++L+GE E++ + E + E+ A + SAE Q A+ A
Sbjct: 2058 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2117
Query: 792 GLRQLLLESQSQLDAAKSEAQKQSDELALVRQQL--SEMKSHVEDGDIAGAPASSPEAPP 849
L +++ +AA+ + Q+++ AL ++Q +EM+ H + A + +
Sbjct: 2118 QAAAEKLRKEAEQEAAR---RAQAEQAALRQKQAADAEMEKHKK-----FAEQTLRQKAQ 2169
Query: 850 AEQDPVQLKTQLEWT--EAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLES 907
EQ+ L+ QLE T + L DE+ QR L AE EA +++EEL +R
Sbjct: 2170 VEQELTTLRLQLEETDHQKNLLDEELQR--LKAEATEAARQRSQVEEELFSVRV------ 2221
Query: 908 SETEEASQLKERLEKE-----------------------KKLTSDLGRAATRLQE---LL 941
+ EE S+LK R+E E K++ + R + QE L
Sbjct: 2222 -QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2280
Query: 942 KTTQEQLAREKDTVKK-LQEQLEKAEDGSSSK 972
+ +E LA+++ +K L+E+++ ++ + K
Sbjct: 2281 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2312
Score = 120 bits (302), Expect = 5e-27
Identities = 226/1009 (22%), Positives = 419/1009 (41%), Gaps = 122/1009 (12%)
Query: 35 ETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKK--EEKPNGKIPDHDPAPNV 92
E +E ++E+ + V+ ++++++++++ + ++ E + K + A
Sbjct: 1373 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1432
Query: 93 TVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPA 152
+ + E +R + + T Q + + A +E A + +++ E+ +V+
Sbjct: 1433 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1492
Query: 153 VSSVVNSIQVLTSKA-AILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADG 211
+ L S+ A E A ++ R + +EA + + ++
Sbjct: 1493 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQV 1551
Query: 212 PLYLPYKTLVSTVGSM--VFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQL 269
L ++ + + S F E AQ L L E+ + +A ++ A +R
Sbjct: 1552 ALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1610
Query: 270 EEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
EE E+ L Q A A +LR +E+A +K+ A A EA+ +K+ RE AR
Sbjct: 1611 EEAERELERWQLKANEAL-RLRLQAEEVAQQKSLAQA-EAEKQKEEAERE-------ARR 1661
Query: 330 QASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNA 389
+ E ++L + Q QL G Q +QE LR Q Q + +
Sbjct: 1662 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE- 1720
Query: 390 ELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQK 449
ELA+L++E + +++ E + + + + L A A E++ ++ EA
Sbjct: 1721 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1780
Query: 450 RLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQ 509
R E++ E A LRA AE+A+ +Q+Q+AE + Q +EAE R E+L+ +
Sbjct: 1781 RFRELAEEA-------ARLRALAEEAK-RQRQLAEEDAARQRAEAE-RVLAEKLAAIGEA 1831
Query: 510 ----------LQEARAENSQLTERIRSIEAL----LEAGQARDAQDVQ--------ASQA 547
L+E AEN +L R+ EA LE A+ D++ AS +
Sbjct: 1832 TRLKTEAEIALKEKEAENERL-RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1890
Query: 548 EADQQQTRLKELESQVSGLEKEAIELREAVEQQ------------KVKNN---DLREKNW 592
E ++Q+ +++ Q +E+E + L+ + E+ ++++N LR K
Sbjct: 1891 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1950
Query: 593 KAMEA-----LATAEQA----CKEKLHSLTQAKEESEKQ--LCLIEAQTMEALLALLPEL 641
+EA LA E+ +E++ A+EE+ +Q L E + ++A + L
Sbjct: 1951 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2010
Query: 642 SVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSI 701
A+Q LQ +E L+ AE + + ++ +E Q TLQ E +S+
Sbjct: 2011 RERAEQESARQLQLAQEAAQKRLQ-----AEEKAHAFAVQQKEQELQQTLQQE----QSV 2061
Query: 702 LAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQV 761
L + G +++ EE E+ A+V A E Q R E E+LK E Q
Sbjct: 2062 LDQLRGEAEAARRAAEEAEE---ARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQA 2113
Query: 762 REHTSHLEAELEKHMAAASAECQNYAK-EVAGLRQLLLESQSQLDAAKSEAQKQSDELAL 820
R + +A EK A E A+ E A LRQ + ++++ K A++ + A
Sbjct: 2114 R---AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAEQTLRQKAQ 2169
Query: 821 VRQQLSEMKSHVEDGDIAG------APASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQ 874
V Q+L+ ++ +E+ D EA A + Q++ +L +E+
Sbjct: 2170 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2229
Query: 875 RQKLTAE-----FEEAQTSACRLQEELEKLRT--------------AGPLESSETEEASQ 915
+ ++ AE + + LQEE EK++ A L E+ +Q
Sbjct: 2230 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2289
Query: 916 LKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEK 964
+ EK K + ATRL+ + Q+Q ++ ++LQE E+
Sbjct: 2290 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2338
Score = 113 bits (283), Expect = 8e-25
Identities = 192/851 (22%), Positives = 366/851 (43%), Gaps = 106/851 (12%)
Query: 183 AQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLV---STVGSMVFNE-GEAQRLI 238
AQ+ A E A K S K + +A P + + + VG + GE +
Sbjct: 1101 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1160
Query: 239 EILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMA 298
E E+ + + W + D + +R+LE+ + L +E A + L++ +
Sbjct: 1161 ERWRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1217
Query: 299 AEKAKAAAGEAKVKKQLVAREQEITAVQAR------MQASYREHVKEVQQLQGKIRTLQE 352
+A A V++QL + + ++ Q ++++ ++ + ++ T +
Sbjct: 1218 QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1277
Query: 353 QLEN--GPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSE 410
QLE P + S++++ ++ T +EL L + K E + + E
Sbjct: 1278 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHY------SELTTLTSQYIKFISETLRRME 1331
Query: 411 -----AVRQDEQQRKALEAKAAAFEKQVLQLQASH--------RESEEALQKRLDEVSRE 457
A +Q ++R+ L AA EKQ QL +H RE++E Q+ +EV R
Sbjct: 1332 EEERLAEQQRAEERERLAEVEAALEKQ-RQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1390
Query: 458 LCHTQSSHASLRADAEKAQE-QQQQMAELHSKLQSSEAEVRSKC---EEL---------- 503
+ R+ E+ Q+ +Q AE+ +K + +EA RS+ EE+
Sbjct: 1391 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1450
Query: 504 ----SGLHGQLQ--EARAENSQLTERIRSIEALL-------EAGQARDAQDVQASQAEAD 550
G G+LQ ARAE ++ +R EA E+ + R A+ AS+ +A+
Sbjct: 1451 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1510
Query: 551 QQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLH 610
+ R E + + LE+ ++ EA +++++ ++ E+ + AL TA+++ + +L
Sbjct: 1511 AEAAR--EKQRALQALEELRLQAEEA--ERRLRQAEV-ERARQVQVALETAQRSAEAELQ 1565
Query: 611 SLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAP 670
S + E QL + A+ L E AQQ + +E+ L+
Sbjct: 1566 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE--AERAREEAERELERWQLK 1623
Query: 671 AEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAA 730
A + L + E + +S QAE ++ + E R+ ++ + EEQ R + A
Sbjct: 1624 ANEALRLRLQAEEVAQQKSLAQAEAEK------QKEEAEREARRRGKAEEQAVRQR-ELA 1676
Query: 731 EEELQKSRVTVK-------HLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAEC 783
E+EL+K R + E+ + +L+ E E +Q R+ A L++ AAA+ +
Sbjct: 1677 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1736
Query: 784 QNYAKEVAGLR---QLLLESQSQLD---AAKSEAQKQSDELALVR-QQLSEMKSHVEDGD 836
Q E+A +R ++LL S+++ + + SE KQ E R ++L+E + +
Sbjct: 1737 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR--- 1793
Query: 837 IAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEEL 896
A A + + AE+D + + + E +L ++ + T EA+ + + E
Sbjct: 1794 -ALAEEAKRQRQLAEEDAARQRAE---AERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1849
Query: 897 EKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVK 956
E+LR L E + +L+E+ + K +D+ RL +L K + +L R+K V+
Sbjct: 1850 ERLRR---LAEDEAFQRRRLEEQAAQHK---ADI---EERLAQLRKASDSELERQKGLVE 1900
Query: 957 KLQEQLEKAED 967
Q + E+
Sbjct: 1901 DTLRQRRQVEE 1911
Score = 111 bits (278), Expect = 3e-24
Identities = 176/765 (23%), Positives = 322/765 (42%), Gaps = 117/765 (15%)
Query: 266 KRQLEEK-EKLLATEQEDAAVAKSKLRELNKEMA----AEKAKAAAGEAKVKKQLVAREQ 320
+R+ EE+ +K LA E+E A K+ L E+ + A A + + A + ++ +A+E
Sbjct: 1969 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE- 2027
Query: 321 EITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQAT 380
A Q R+QA + H VQQ K + LQ+ L QQE S+L +A
Sbjct: 2028 ---AAQKRLQAEEKAHAFAVQQ---KEQELQQTL-----------QQEQSVLDQLRGEAE 2070
Query: 381 SQVESKQNAELAKLRQELSKV-SKELVEKSEAVRQ--DEQQRKALEAKAAA--FEKQVLQ 435
+ + + AE A+++ E S+ VE++E ++Q +EQ + +A+AAA K+ Q
Sbjct: 2071 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130
Query: 436 LQASHRESEEALQKRLDEVSREL-CHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEA 494
A ++E+A ++ E+ H + + +LR +KAQ +Q+ + L +L+ ++
Sbjct: 2131 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR---QKAQVEQE-LTTLRLQLEETDH 2186
Query: 495 EVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLE--------------AGQARDAQ 540
+ EEL L + EA + SQ+ E + S+ +E A RD
Sbjct: 2187 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2246
Query: 541 DVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAM----- 595
+ Q E ++ ++ E +++S +EA LR+ E+ + L EK K
Sbjct: 2247 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2306
Query: 596 ---------EALATAEQACKEKLHSLTQAKEESEKQLC--------------------LI 626
E L ++ +E+ L + KE+ +QL
Sbjct: 2307 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2366
Query: 627 EAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEE 686
EA+ ++ +A + A+++ + + +E G L + A E + L L E +
Sbjct: 2367 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTL-EIQR 2424
Query: 687 TQSTLQAECDQYRSILAETEGMLRDLQKSV-------EEEEQVWRAKVGAAEEELQKSRV 739
QS AE + R +AE E LQ+ EE + V + ++ + LQ+S +
Sbjct: 2425 QQSDHDAE--RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2482
Query: 740 TVK----HLEEIVEKLKGELES--------SDQVREHTSHLEAELEKHMAAASAECQNYA 787
+ K E +E+ K +LE + Q+RE + ++E+ A +
Sbjct: 2483 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2542
Query: 788 KEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEA 847
+ + + Q +L + + ++Q + LA Q+L E +E+ A A A S E
Sbjct: 2543 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA-ALAHSEEV 2601
Query: 848 PPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLES 907
++ KT +A+ + + + + SA RLQE AG L +
Sbjct: 2602 TASQ--VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE-------AGILSA 2652
Query: 908 SETEEASQ---LKERLEKEKKLTSDLGRAATRLQELLKTTQEQLA 949
E + +Q + L + + + L ++ LLK T E+L+
Sbjct: 2653 EELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLS 2697
Score = 91.3 bits (225), Expect = 4e-18
Identities = 142/624 (22%), Positives = 248/624 (39%), Gaps = 69/624 (11%)
Query: 364 RLQQENSILRDALNQATSQVESKQNAE-LAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
RL + R+ + Q +++ E L K LS +++++ E R L
Sbjct: 994 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1053
Query: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM 482
E E QV L A + E +L +S + TQ + LRA E+ +E Q
Sbjct: 1054 ELTLGKLE-QVRSLSAIYLE-------KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1105
Query: 483 AEL------HSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQA 536
A L + L+ A+ ++ L +L+ A+ +L +R + +E +
Sbjct: 1106 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1165
Query: 537 RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAME 596
R AQ ++ QA Q R +ELE L ++ RE+ + D R + +
Sbjct: 1166 RVAQLLERWQAVLAQTDVRQRELEQ----LGRQLRYYRESADPLGAWLQDARRRQEQIQA 1221
Query: 597 ALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDL 656
QA +E+L EE E+ +E Q+ +++ +
Sbjct: 1222 MPLADSQAVREQLRQEQALLEEIERHGEKVEE----------------CQRFAKQYINAI 1265
Query: 657 KEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSV 716
K+ L+ + A EP + A K + ++S +Q D R+ +E + K +
Sbjct: 1266 KDYELQLVTYK-AQLEPVASPAKKPKVQSGSESVIQEYVD-LRTHYSELTTLTSQYIKFI 1323
Query: 717 EEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHM 776
E T++ +EE E+ E + +++ RE + +EA LEK
Sbjct: 1324 SE---------------------TLRRMEE--EERLAEQQRAEE-RERLAEVEAALEKQR 1359
Query: 777 AAASAECQNYA---KEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVE 833
A A Q A +E L+Q + E + + A +AQ+Q + QQL +
Sbjct: 1360 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1419
Query: 834 DGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQ 893
A A+ E++ ++ QLE TE + + Q L A EEA+ + Q
Sbjct: 1420 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1479
Query: 894 EELEKLRTAGPLESSETEEAS-QLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAR-- 950
EE E+LR ES +A +L R++ E + + RA L+EL +E R
Sbjct: 1480 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1539
Query: 951 --EKDTVKKLQEQLEKAEDGSSSK 972
E + +++Q LE A+ + ++
Sbjct: 1540 QAEVERARQVQVALETAQRSAEAE 1563
Score = 76.3 bits (186), Expect = 1e-13
Identities = 119/582 (20%), Positives = 255/582 (43%), Gaps = 45/582 (7%)
Query: 143 EKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSK 202
++K +++ + + + L +A A +E V EA + ++ K
Sbjct: 2045 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2104
Query: 203 KKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDT-----WHKATQ 257
+ A + + E E + +E+A + Q K +
Sbjct: 2105 QSAEEQAQA------RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2158
Query: 258 KGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVA 317
+ K Q+E++ L + E+ K+ L E + + AE +AA ++V+++L +
Sbjct: 2159 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2218
Query: 318 ---REQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRD 374
+ +E++ ++AR++A R + ++ R LQE+ E ++ ++ +E + L
Sbjct: 2219 VRVQMEELSKLKARIEAENRALI--LRDKDNTQRFLQEEAE-----KMKQVAEEAARLSV 2271
Query: 375 ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVL 434
A +A +Q AE L Q+ + K L EK +AV+ E R EA+ +K++
Sbjct: 2272 AAQEAA---RLRQLAE-EDLAQQRALAEKMLKEKMQAVQ--EATRLKAEAELLQQQKELA 2325
Query: 435 QLQASH-RESEEALQKRLDEVSRELCHT----QSSHASLRADAEKAQEQQQQMAELHSKL 489
Q QA +E +E + ++L E ++ T + + A+AE+ + + +M+ ++
Sbjct: 2326 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2385
Query: 490 QSSEAEVRSKCEELSGLHGQLQEARAENSQL--TERIRSIEALLEAGQARDAQDVQASQA 547
+ R + EE+ + + A E L T I+ ++ +A + R+A +
Sbjct: 2386 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2445
Query: 548 EADQQQTRLKELESQ--VSGLEKEAIELREAVEQQKVKNND-LREKNWKAMEALATAEQA 604
E QQ+ +L +L+S+ + +++ ++ +A++Q + D L ++ + A EQ
Sbjct: 2446 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2505
Query: 605 CKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLL 664
++++ Q +EE ++Q +E Q + L+A + E A++ E + ++ K L
Sbjct: 2506 FQDEVAKAQQLREEQQRQQQQME-QERQRLVASMEE----ARRRQHEAEEGVRRKQEELQ 2560
Query: 665 KHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETE 706
+ + LA E + + LQ +Q+R+ LA +E
Sbjct: 2561 QLEQQRRQQEELLA---EENQRLREQLQLLEEQHRAALAHSE 2599
Score = 52.4 bits (124), Expect = 2e-06
Identities = 169/750 (22%), Positives = 280/750 (37%), Gaps = 152/750 (20%)
Query: 295 KEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKI------- 347
KEM +A +K Q + E + A Q ++ Y H +V++ GK+
Sbjct: 311 KEMELPAKEADKNRSKGIYQSL--EGAVQAGQLKVPPGY--HPLDVEKEWGKLHVAILER 366
Query: 348 -RTLQEQLENGPNTQ--LARLQQENSILRDALNQATSQVESKQNAELA-KLRQELSKVSK 403
+ L+ + E Q + +LQ E + + LNQA + ++S A K+ Q +V +
Sbjct: 367 EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVER 426
Query: 404 ELVEKSEAVR---------------QDEQQRKAL----EAKAAAFEKQVLQLQAS-HRES 443
+L + +R Q EQ + + E A + L+L+A +
Sbjct: 427 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 486
Query: 444 EEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM--AELHSKLQSSEAEVRSKCE 501
+ Q L V R S+ L+ +E Q ++ AE L S EA++ S
Sbjct: 487 TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH-- 544
Query: 502 ELSGLHGQLQEARAENSQLTERIRSIEALLEA---GQARDAQ---DVQASQAEADQQQTR 555
GLH ++E RA+ ER RS E L G RD D+Q ++ + + R
Sbjct: 545 --RGLHQSIEEFRAK----IERARSDEGQLSPATRGAYRDCLGRLDLQYAKL-LNSSKAR 597
Query: 556 LKELESQ---VSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSL 612
L+ LES V+ KE + L E E++ D ++N T A KE +L
Sbjct: 598 LRSLESLHSFVAAATKELMWLNEKEEEEV--GFDWSDRN--------TNMTAKKESYSAL 647
Query: 613 TQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLK--HPPAP 670
+ E EK++ ++L+ G LL+ HP P
Sbjct: 648 MRELELKEKKI------------------------------KELQNAGDRLLREDHPARP 677
Query: 671 AEPSSDLASKLREAEETQSTLQAECD--------QYRSILAETEGMLRDLQKSVEEEEQV 722
S A + + + Q E Q+ S + E EG L+ LQ+++ +
Sbjct: 678 TVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSC 737
Query: 723 WRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAE 782
R+ TV LE++++ + E E Q+ E+ HL ++ A +
Sbjct: 738 DRS-------------ATVTRLEDLLQDAQDEKE---QLNEYKGHLSGLAKRAKAVVQLK 781
Query: 783 CQNYAKEVAGLRQLLLESQSQLDAAKSEAQ-KQSDELALV-RQQLSEMKSHVEDGDIAGA 840
++ A + G LL + D + E + DE LV Q S K G A
Sbjct: 782 PRHPAHPMRGRLPLL----AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAV 837
Query: 841 PASSPEAPPAEQDP----------------------VQLKTQLEWTEAILEDEQTQRQKL 878
P+ PP Q+ V +K+ L W +++ D Q R
Sbjct: 838 PSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW-QSLRRDVQLIRSWS 896
Query: 879 TAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQ 938
A F + R +L L S+ ++RL E++ S LQ
Sbjct: 897 LATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQ 956
Query: 939 ELLKTTQEQLAREK--DTVKKLQEQLEKAE 966
L + QE+ ++ +K ++ QLE E
Sbjct: 957 SLEQGAQEESRCQRCISELKDIRLQLEACE 986
Score = 37.7 bits (86), Expect = 0.053
Identities = 109/534 (20%), Positives = 200/534 (37%), Gaps = 48/534 (8%)
Query: 39 EEALANQR---KEMAKTHHQKVEK------------KKKEKTVEKKGKTKKKEEKPNGKI 83
EE LA QR ++M K Q V++ ++KE E+ + ++ +E+ ++
Sbjct: 2284 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2343
Query: 84 PDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKE 143
+ T+ E R + ++ + + VA ++ A +E K ++
Sbjct: 2344 AEETQGFQRTL---EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2400
Query: 144 KKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKK 203
+K+ + E A V +Q L + + + R E K + AK +
Sbjct: 2401 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2460
Query: 204 KGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGI---IQDTWHKATQKGD 260
+ L + L + S + + +R IE EKA + QD KA Q +
Sbjct: 2461 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE--QEKAKLEQLFQDEVAKAQQLRE 2518
Query: 261 PVAILKRQLEEKEKLLATEQEDAA----VAKSKLRELNKEM-AAEKAKAAAGEAKVKKQL 315
++Q+E++ + L E+A A+ +R +E+ E+ + E ++
Sbjct: 2519 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2578
Query: 316 VAREQ-EITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRD 374
REQ ++ Q R ++ E V Q K +GP + + + R
Sbjct: 2579 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRK 2638
Query: 375 ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVL 434
Q + EL +L Q + V + + + E VR Q R ++ + L
Sbjct: 2639 VSAQRLQEAGILSAEELQRLAQGHTTVDE--LARREDVRHYLQGRSSIAGLLLKATNEKL 2696
Query: 435 QLQASHRESEEALQKRLDEVSRELCHTQSSHAS---------LRADAEKAQEQQQQMAEL 485
+ A ALQ++L L ++ AS R +A ++ EL
Sbjct: 2697 SVYA-------ALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPEL 2749
Query: 486 HSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTER-IRSIEALLEAGQARD 538
H KL S+E V + +G L +A + + E IR +EA + G D
Sbjct: 2750 HHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVID 2803
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 132 bits (333), Expect = 1e-30
Identities = 221/1001 (22%), Positives = 413/1001 (41%), Gaps = 150/1001 (14%)
Query: 40 EALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREP 99
E A +++E+A+ Q++EK+++ + + ++E + +L E
Sbjct: 1707 EEQAVRQRELAE---QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1763
Query: 100 VRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNS 159
R A A T + + A +A V A + LAS + +++ K + + +
Sbjct: 1764 ARLQREAAAATQKRQEL-EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1822
Query: 160 IQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKT 219
+ L +AA L +E + +A +Q A A++ K +A T
Sbjct: 1823 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA---------T 1873
Query: 220 LVSTVGSMVFNEGEAQ--RLIEILSEKAGII-----QDTWHKAT---------------- 256
+ T + E EA+ RL + ++A Q HKA
Sbjct: 1874 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1933
Query: 257 --QKG--DPVAILKRQLEEKEKLLATEQEDAAVAKSKL-----------------RELNK 295
QKG + +RQ+EE+ L E AA K++L +E +
Sbjct: 1934 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1993
Query: 296 EMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKI---RTLQE 352
AA + + AA E + +++ R Q+ A + + ++EV++L+ K+ R L+E
Sbjct: 1994 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2053
Query: 353 QLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAV 412
+ E QL Q+ A +A + ++ EL + Q+ V +L ++EA
Sbjct: 2054 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2113
Query: 413 R----QDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDE--VSRELCHTQSSHA 466
R + E+ R E +AA +QV + + + +EE Q R + +L A
Sbjct: 2114 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173
Query: 467 SLRADAEKAQEQQQQMA--ELHSKLQSSEAEVRSKCE---ELSGLHGQLQEARAENSQLT 521
+ RA AE+A +Q+Q A E+ + +E +R K + EL+ L QL+E + + L
Sbjct: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233
Query: 522 ERIRSIEALLEAGQA-RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQ 580
E ++ ++A EA +A R V+ Q L +L++++ E A+ LR+ Q
Sbjct: 2234 EELQRLKA--EATEAARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQ 2290
Query: 581 KVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPE 640
+ + EK + E A A +E A+E+ +Q L E E + A+
Sbjct: 2291 RFLQEEA-EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2349
Query: 641 LSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQS---TLQAECDQ 697
+ A+ + ++L ++ L+ E +A +L AEETQ TL+AE +
Sbjct: 2350 TRLKAEAELLQQQKELAQEQARRLQ------EDKEQMAQQL--AEETQGFQRTLEAERQR 2401
Query: 698 YRSILAETEGM------LRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKL 751
+ AE E + + Q EE+ Q +R + E+L ++ + + +V+ L
Sbjct: 2402 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2461
Query: 752 KGELESSD----QVREHTSHLEAELEK-HMAAASAECQNYAKEVAGLRQLLLESQSQLDA 806
+ + + SD ++RE + LE E EK A + ++ + QLL E+Q+ +
Sbjct: 2462 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2521
Query: 807 AKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEA 866
SE + Q+ ++++ +D ++A A QL+ + + +
Sbjct: 2522 FLSEKDSLLQRERFIEQEKAKLEQLFQD-EVAKAQ--------------QLREEQQRQQQ 2566
Query: 867 ILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKL 926
+E E RQ+L A EEA+ +E + + + EE QL+++
Sbjct: 2567 QMEQE---RQRLVASMEEARRRQHEAEEGVRR----------KQEELQQLEQQ------- 2606
Query: 927 TSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAED 967
+ QE+L E++ ++L+EQL+ E+
Sbjct: 2607 ---------------RRQQEELLAEEN--QRLREQLQLLEE 2630
Score = 131 bits (329), Expect = 4e-30
Identities = 191/766 (24%), Positives = 334/766 (43%), Gaps = 108/766 (14%)
Query: 267 RQLEEKEKLL----ATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEI 322
R++EE+E+L A E+E A ++ L E +++A A+A A + K+L R QE
Sbjct: 1369 RRMEEEERLAEQQRAEERERLAEVEAAL-EKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1427
Query: 323 T------AVQARMQA-SYREHVKEVQQL-QGKIRTLQEQLENGPNTQLARLQQENSILRD 374
AV A+ Q S +E +++++Q + +I+ Q E ++L R+++E ++R
Sbjct: 1428 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVVRL 1486
Query: 375 ALNQATSQVESKQNAELAKLR---QELSKVSKELVEKSEAVR---QDEQQRKA------- 421
L +AT + EL LR +E ++ E++E +R QDE QRK
Sbjct: 1487 QL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1545
Query: 422 ----LEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHT---------QSSHASL 468
EA+AA +++ LQ R E ++RL + E +S+ A L
Sbjct: 1546 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1605
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTER--IRS 526
++ E+ Q+ + + A++R + E + + + AR E + ER +++
Sbjct: 1606 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1665
Query: 527 IEALLEAGQARD-AQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNN 585
EAL QA + AQ +QAEA++Q+ + + E++A+ RE EQ+ K
Sbjct: 1666 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1725
Query: 586 DLREKNWKAMEALATAEQ--ACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSV 643
L E TA+Q A +++L L E+ E+Q L+E + LA L +
Sbjct: 1726 QLAE---------GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAA 1771
Query: 644 LAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQST-------LQAECD 696
A Q E +L + AE LASK R EE++ST L+AE
Sbjct: 1772 AATQKRQELEAELAK----------VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1821
Query: 697 QYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELE 756
++R LAE LR L + + + Q+ A+ AA + + RV + L I E + + E
Sbjct: 1822 RFRE-LAEEAARLRALAEEAKRQRQL--AEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1878
Query: 757 SSDQVREHTSHLEAELEKHMAAASAEC-----------QNYAKEVAGLRQLLLESQSQLD 805
+ ++E EAE E+ A E Q+ A L QL S S+L+
Sbjct: 1879 AEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1934
Query: 806 AAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSP--EAPPAEQDPVQLKTQLEW 863
K + + V +++ +K+ E A +D ++ K Q E
Sbjct: 1935 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1994
Query: 864 TEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKE 923
A + ++ E EE + +EE + R A EE +LK ++E+
Sbjct: 1995 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA------LEEVERLKAKVEEA 2048
Query: 924 KKLTSDLGR-AATRLQELLKTTQEQLAREKD----TVKKLQEQLEK 964
++L + +A +LQ + Q++L E+ V++ +++L++
Sbjct: 2049 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2094
Score = 125 bits (313), Expect = 3e-28
Identities = 182/812 (22%), Positives = 335/812 (41%), Gaps = 111/812 (13%)
Query: 231 EGEAQRLIEILSEKA--GIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKS 288
E E R +++ E A + K + A L+R L+E+ +A +E+A
Sbjct: 1583 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE---- 1638
Query: 289 KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIR 348
R ++ AE+A+ A + QL A E A++ R+QA K + Q +
Sbjct: 1639 --RRAQQQAEAERAREEAERELERWQLKANE----ALRLRLQAEEVAQQKSLAQAEA--- 1689
Query: 349 TLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEK 408
++Q E R + E +R A ++E ++ +Q L+ +EL+
Sbjct: 1690 --EKQKEEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLAEGTAQQRLA-AEQELIRL 1745
Query: 409 SEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASL 468
Q EQQR+ LE + A +++ +E E L K E+ L +
Sbjct: 1746 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1805
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERI--RS 526
R+ +EK++++ + A +L A +R+ EE +E A ER+
Sbjct: 1806 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1865
Query: 527 IEALLEAGQARDAQDVQASQAEADQ------------QQTRLKELESQ-VSGLEKEAIEL 573
+ A+ EA + + ++ + EA+ Q+ RL+E +Q + +E+ +L
Sbjct: 1866 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1925
Query: 574 REAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEA 633
R+A + + + L E + + A K K E E +L I + +
Sbjct: 1926 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1985
Query: 634 LLAL-LPELSVLAQ-QNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTL 691
L + EL Q Q E + +E + K A E + + L E E ++ +
Sbjct: 1986 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2045
Query: 692 Q--------AECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKH 743
+ AE + R + E QK ++ EE+ V E+ELQ+ T++
Sbjct: 2046 EEARRLRERAEQESARQLQLAQEA----AQKRLQAEEKAHAFAVQQKEQELQQ---TLQQ 2098
Query: 744 LEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAA------------SAECQNYAKEVA 791
+ ++++L+GE E++ + E + E+ A + SAE Q A+ A
Sbjct: 2099 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2158
Query: 792 GLRQLLLESQSQLDAAKSEAQKQSDELALVRQQL--SEMKSHVEDGDIAGAPASSPEAPP 849
L +++ +AA+ + Q+++ AL ++Q +EM+ H + A + +
Sbjct: 2159 QAAAEKLRKEAEQEAAR---RAQAEQAALRQKQAADAEMEKHKK-----FAEQTLRQKAQ 2210
Query: 850 AEQDPVQLKTQLEWT--EAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLES 907
EQ+ L+ QLE T + L DE+ QR L AE EA +++EEL +R
Sbjct: 2211 VEQELTTLRLQLEETDHQKNLLDEELQR--LKAEATEAARQRSQVEEELFSVRV------ 2262
Query: 908 SETEEASQLKERLEKE-----------------------KKLTSDLGRAATRLQE---LL 941
+ EE S+LK R+E E K++ + R + QE L
Sbjct: 2263 -QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2321
Query: 942 KTTQEQLAREKDTVKK-LQEQLEKAEDGSSSK 972
+ +E LA+++ +K L+E+++ ++ + K
Sbjct: 2322 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2353
Score = 120 bits (302), Expect = 5e-27
Identities = 226/1009 (22%), Positives = 419/1009 (41%), Gaps = 122/1009 (12%)
Query: 35 ETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKK--EEKPNGKIPDHDPAPNV 92
E +E ++E+ + V+ ++++++++++ + ++ E + K + A
Sbjct: 1414 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1473
Query: 93 TVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPA 152
+ + E +R + + T Q + + A +E A + +++ E+ +V+
Sbjct: 1474 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533
Query: 153 VSSVVNSIQVLTSKA-AILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADG 211
+ L S+ A E A ++ R + +EA + + ++
Sbjct: 1534 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQV 1592
Query: 212 PLYLPYKTLVSTVGSM--VFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQL 269
L ++ + + S F E AQ L L E+ + +A ++ A +R
Sbjct: 1593 ALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1651
Query: 270 EEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
EE E+ L Q A A +LR +E+A +K+ A A EA+ +K+ RE AR
Sbjct: 1652 EEAERELERWQLKANEAL-RLRLQAEEVAQQKSLAQA-EAEKQKEEAERE-------ARR 1702
Query: 330 QASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNA 389
+ E ++L + Q QL G Q +QE LR Q Q + +
Sbjct: 1703 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE- 1761
Query: 390 ELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQK 449
ELA+L++E + +++ E + + + + L A A E++ ++ EA
Sbjct: 1762 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1821
Query: 450 RLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQ 509
R E++ E A LRA AE+A+ +Q+Q+AE + Q +EAE R E+L+ +
Sbjct: 1822 RFRELAEEA-------ARLRALAEEAK-RQRQLAEEDAARQRAEAE-RVLAEKLAAIGEA 1872
Query: 510 ----------LQEARAENSQLTERIRSIEAL----LEAGQARDAQDVQ--------ASQA 547
L+E AEN +L R+ EA LE A+ D++ AS +
Sbjct: 1873 TRLKTEAEIALKEKEAENERL-RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1931
Query: 548 EADQQQTRLKELESQVSGLEKEAIELREAVEQQ------------KVKNN---DLREKNW 592
E ++Q+ +++ Q +E+E + L+ + E+ ++++N LR K
Sbjct: 1932 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1991
Query: 593 KAMEA-----LATAEQA----CKEKLHSLTQAKEESEKQ--LCLIEAQTMEALLALLPEL 641
+EA LA E+ +E++ A+EE+ +Q L E + ++A + L
Sbjct: 1992 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2051
Query: 642 SVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSI 701
A+Q LQ +E L+ AE + + ++ +E Q TLQ E +S+
Sbjct: 2052 RERAEQESARQLQLAQEAAQKRLQ-----AEEKAHAFAVQQKEQELQQTLQQE----QSV 2102
Query: 702 LAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQV 761
L + G +++ EE E+ A+V A E Q R E E+LK E Q
Sbjct: 2103 LDQLRGEAEAARRAAEEAEE---ARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQA 2154
Query: 762 REHTSHLEAELEKHMAAASAECQNYAK-EVAGLRQLLLESQSQLDAAKSEAQKQSDELAL 820
R + +A EK A E A+ E A LRQ + ++++ K A++ + A
Sbjct: 2155 R---AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAEQTLRQKAQ 2210
Query: 821 VRQQLSEMKSHVEDGDIAG------APASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQ 874
V Q+L+ ++ +E+ D EA A + Q++ +L +E+
Sbjct: 2211 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2270
Query: 875 RQKLTAE-----FEEAQTSACRLQEELEKLRT--------------AGPLESSETEEASQ 915
+ ++ AE + + LQEE EK++ A L E+ +Q
Sbjct: 2271 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2330
Query: 916 LKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEK 964
+ EK K + ATRL+ + Q+Q ++ ++LQE E+
Sbjct: 2331 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2379
Score = 113 bits (283), Expect = 8e-25
Identities = 192/851 (22%), Positives = 366/851 (43%), Gaps = 106/851 (12%)
Query: 183 AQSPEAPKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLV---STVGSMVFNE-GEAQRLI 238
AQ+ A E A K S K + +A P + + + VG + GE +
Sbjct: 1142 AQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1201
Query: 239 EILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMA 298
E E+ + + W + D + +R+LE+ + L +E A + L++ +
Sbjct: 1202 ERWRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1258
Query: 299 AEKAKAAAGEAKVKKQLVAREQEITAVQAR------MQASYREHVKEVQQLQGKIRTLQE 352
+A A V++QL + + ++ Q ++++ ++ + ++ T +
Sbjct: 1259 QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1318
Query: 353 QLEN--GPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSE 410
QLE P + S++++ ++ T +EL L + K E + + E
Sbjct: 1319 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHY------SELTTLTSQYIKFISETLRRME 1372
Query: 411 -----AVRQDEQQRKALEAKAAAFEKQVLQLQASH--------RESEEALQKRLDEVSRE 457
A +Q ++R+ L AA EKQ QL +H RE++E Q+ +EV R
Sbjct: 1373 EEERLAEQQRAEERERLAEVEAALEKQ-RQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1431
Query: 458 LCHTQSSHASLRADAEKAQE-QQQQMAELHSKLQSSEAEVRSKC---EEL---------- 503
+ R+ E+ Q+ +Q AE+ +K + +EA RS+ EE+
Sbjct: 1432 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1491
Query: 504 ----SGLHGQLQ--EARAENSQLTERIRSIEALL-------EAGQARDAQDVQASQAEAD 550
G G+LQ ARAE ++ +R EA E+ + R A+ AS+ +A+
Sbjct: 1492 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1551
Query: 551 QQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLH 610
+ R E + + LE+ ++ EA +++++ ++ E+ + AL TA+++ + +L
Sbjct: 1552 AEAAR--EKQRALQALEELRLQAEEA--ERRLRQAEV-ERARQVQVALETAQRSAEAELQ 1606
Query: 611 SLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAP 670
S + E QL + A+ L E AQQ + +E+ L+
Sbjct: 1607 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE--AERAREEAERELERWQLK 1664
Query: 671 AEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAA 730
A + L + E + +S QAE ++ + E R+ ++ + EEQ R + A
Sbjct: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEK------QKEEAEREARRRGKAEEQAVRQR-ELA 1717
Query: 731 EEELQKSRVTVK-------HLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAEC 783
E+EL+K R + E+ + +L+ E E +Q R+ A L++ AAA+ +
Sbjct: 1718 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1777
Query: 784 QNYAKEVAGLR---QLLLESQSQLD---AAKSEAQKQSDELALVR-QQLSEMKSHVEDGD 836
Q E+A +R ++LL S+++ + + SE KQ E R ++L+E + +
Sbjct: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR--- 1834
Query: 837 IAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEEL 896
A A + + AE+D + + + E +L ++ + T EA+ + + E
Sbjct: 1835 -ALAEEAKRQRQLAEEDAARQRAE---AERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1890
Query: 897 EKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVK 956
E+LR L E + +L+E+ + K +D+ RL +L K + +L R+K V+
Sbjct: 1891 ERLRR---LAEDEAFQRRRLEEQAAQHK---ADI---EERLAQLRKASDSELERQKGLVE 1941
Query: 957 KLQEQLEKAED 967
Q + E+
Sbjct: 1942 DTLRQRRQVEE 1952
Score = 111 bits (278), Expect = 3e-24
Identities = 176/765 (23%), Positives = 322/765 (42%), Gaps = 117/765 (15%)
Query: 266 KRQLEEK-EKLLATEQEDAAVAKSKLRELNKEMA----AEKAKAAAGEAKVKKQLVAREQ 320
+R+ EE+ +K LA E+E A K+ L E+ + A A + + A + ++ +A+E
Sbjct: 2010 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE- 2068
Query: 321 EITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQAT 380
A Q R+QA + H VQQ K + LQ+ L QQE S+L +A
Sbjct: 2069 ---AAQKRLQAEEKAHAFAVQQ---KEQELQQTL-----------QQEQSVLDQLRGEAE 2111
Query: 381 SQVESKQNAELAKLRQELSKV-SKELVEKSEAVRQ--DEQQRKALEAKAAA--FEKQVLQ 435
+ + + AE A+++ E S+ VE++E ++Q +EQ + +A+AAA K+ Q
Sbjct: 2112 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2171
Query: 436 LQASHRESEEALQKRLDEVSREL-CHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEA 494
A ++E+A ++ E+ H + + +LR +KAQ +Q+ + L +L+ ++
Sbjct: 2172 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR---QKAQVEQE-LTTLRLQLEETDH 2227
Query: 495 EVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLE--------------AGQARDAQ 540
+ EEL L + EA + SQ+ E + S+ +E A RD
Sbjct: 2228 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2287
Query: 541 DVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAM----- 595
+ Q E ++ ++ E +++S +EA LR+ E+ + L EK K
Sbjct: 2288 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2347
Query: 596 ---------EALATAEQACKEKLHSLTQAKEESEKQLC--------------------LI 626
E L ++ +E+ L + KE+ +QL
Sbjct: 2348 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2407
Query: 627 EAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEE 686
EA+ ++ +A + A+++ + + +E G L + A E + L L E +
Sbjct: 2408 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTL-EIQR 2465
Query: 687 TQSTLQAECDQYRSILAETEGMLRDLQKSV-------EEEEQVWRAKVGAAEEELQKSRV 739
QS AE + R +AE E LQ+ EE + V + ++ + LQ+S +
Sbjct: 2466 QQSDHDAE--RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2523
Query: 740 TVK----HLEEIVEKLKGELES--------SDQVREHTSHLEAELEKHMAAASAECQNYA 787
+ K E +E+ K +LE + Q+RE + ++E+ A +
Sbjct: 2524 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2583
Query: 788 KEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEA 847
+ + + Q +L + + ++Q + LA Q+L E +E+ A A A S E
Sbjct: 2584 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA-ALAHSEEV 2642
Query: 848 PPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLES 907
++ KT +A+ + + + + SA RLQE AG L +
Sbjct: 2643 TASQ--VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE-------AGILSA 2693
Query: 908 SETEEASQ---LKERLEKEKKLTSDLGRAATRLQELLKTTQEQLA 949
E + +Q + L + + + L ++ LLK T E+L+
Sbjct: 2694 EELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLS 2738
Score = 91.3 bits (225), Expect = 4e-18
Identities = 142/624 (22%), Positives = 248/624 (39%), Gaps = 69/624 (11%)
Query: 364 RLQQENSILRDALNQATSQVESKQNAE-LAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
RL + R+ + Q +++ E L K LS +++++ E R L
Sbjct: 1035 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1094
Query: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM 482
E E QV L A + E +L +S + TQ + LRA E+ +E Q
Sbjct: 1095 ELTLGKLE-QVRSLSAIYLE-------KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1146
Query: 483 AEL------HSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQA 536
A L + L+ A+ ++ L +L+ A+ +L +R + +E +
Sbjct: 1147 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1206
Query: 537 RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAME 596
R AQ ++ QA Q R +ELE L ++ RE+ + D R + +
Sbjct: 1207 RVAQLLERWQAVLAQTDVRQRELEQ----LGRQLRYYRESADPLGAWLQDARRRQEQIQA 1262
Query: 597 ALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDL 656
QA +E+L EE E+ +E Q+ +++ +
Sbjct: 1263 MPLADSQAVREQLRQEQALLEEIERHGEKVEE----------------CQRFAKQYINAI 1306
Query: 657 KEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSV 716
K+ L+ + A EP + A K + ++S +Q D R+ +E + K +
Sbjct: 1307 KDYELQLVTYK-AQLEPVASPAKKPKVQSGSESVIQEYVD-LRTHYSELTTLTSQYIKFI 1364
Query: 717 EEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHM 776
E T++ +EE E+ E + +++ RE + +EA LEK
Sbjct: 1365 SE---------------------TLRRMEE--EERLAEQQRAEE-RERLAEVEAALEKQR 1400
Query: 777 AAASAECQNYA---KEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVE 833
A A Q A +E L+Q + E + + A +AQ+Q + QQL +
Sbjct: 1401 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1460
Query: 834 DGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQ 893
A A+ E++ ++ QLE TE + + Q L A EEA+ + Q
Sbjct: 1461 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1520
Query: 894 EELEKLRTAGPLESSETEEAS-QLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAR-- 950
EE E+LR ES +A +L R++ E + + RA L+EL +E R
Sbjct: 1521 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1580
Query: 951 --EKDTVKKLQEQLEKAEDGSSSK 972
E + +++Q LE A+ + ++
Sbjct: 1581 QAEVERARQVQVALETAQRSAEAE 1604
Score = 76.3 bits (186), Expect = 1e-13
Identities = 119/582 (20%), Positives = 255/582 (43%), Gaps = 45/582 (7%)
Query: 143 EKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSK 202
++K +++ + + + L +A A +E V EA + ++ K
Sbjct: 2086 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2145
Query: 203 KKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDT-----WHKATQ 257
+ A + + E E + +E+A + Q K +
Sbjct: 2146 QSAEEQAQA------RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2199
Query: 258 KGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVA 317
+ K Q+E++ L + E+ K+ L E + + AE +AA ++V+++L +
Sbjct: 2200 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2259
Query: 318 ---REQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRD 374
+ +E++ ++AR++A R + ++ R LQE+ E ++ ++ +E + L
Sbjct: 2260 VRVQMEELSKLKARIEAENRALI--LRDKDNTQRFLQEEAE-----KMKQVAEEAARLSV 2312
Query: 375 ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVL 434
A +A +Q AE L Q+ + K L EK +AV+ E R EA+ +K++
Sbjct: 2313 AAQEAA---RLRQLAE-EDLAQQRALAEKMLKEKMQAVQ--EATRLKAEAELLQQQKELA 2366
Query: 435 QLQASH-RESEEALQKRLDEVSRELCHT----QSSHASLRADAEKAQEQQQQMAELHSKL 489
Q QA +E +E + ++L E ++ T + + A+AE+ + + +M+ ++
Sbjct: 2367 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2426
Query: 490 QSSEAEVRSKCEELSGLHGQLQEARAENSQL--TERIRSIEALLEAGQARDAQDVQASQA 547
+ R + EE+ + + A E L T I+ ++ +A + R+A +
Sbjct: 2427 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2486
Query: 548 EADQQQTRLKELESQ--VSGLEKEAIELREAVEQQKVKNND-LREKNWKAMEALATAEQA 604
E QQ+ +L +L+S+ + +++ ++ +A++Q + D L ++ + A EQ
Sbjct: 2487 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2546
Query: 605 CKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLL 664
++++ Q +EE ++Q +E Q + L+A + E A++ E + ++ K L
Sbjct: 2547 FQDEVAKAQQLREEQQRQQQQME-QERQRLVASMEE----ARRRQHEAEEGVRRKQEELQ 2601
Query: 665 KHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETE 706
+ + LA E + + LQ +Q+R+ LA +E
Sbjct: 2602 QLEQQRRQQEELLA---EENQRLREQLQLLEEQHRAALAHSE 2640
Score = 52.4 bits (124), Expect = 2e-06
Identities = 169/750 (22%), Positives = 280/750 (37%), Gaps = 152/750 (20%)
Query: 295 KEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKI------- 347
KEM +A +K Q + E + A Q ++ Y H +V++ GK+
Sbjct: 352 KEMELPAKEADKNRSKGIYQSL--EGAVQAGQLKVPPGY--HPLDVEKEWGKLHVAILER 407
Query: 348 -RTLQEQLENGPNTQ--LARLQQENSILRDALNQATSQVESKQNAELA-KLRQELSKVSK 403
+ L+ + E Q + +LQ E + + LNQA + ++S A K+ Q +V +
Sbjct: 408 EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVER 467
Query: 404 ELVEKSEAVR---------------QDEQQRKAL----EAKAAAFEKQVLQLQAS-HRES 443
+L + +R Q EQ + + E A + L+L+A +
Sbjct: 468 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 527
Query: 444 EEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQM--AELHSKLQSSEAEVRSKCE 501
+ Q L V R S+ L+ +E Q ++ AE L S EA++ S
Sbjct: 528 TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH-- 585
Query: 502 ELSGLHGQLQEARAENSQLTERIRSIEALLEA---GQARDAQ---DVQASQAEADQQQTR 555
GLH ++E RA+ ER RS E L G RD D+Q ++ + + R
Sbjct: 586 --RGLHQSIEEFRAK----IERARSDEGQLSPATRGAYRDCLGRLDLQYAKL-LNSSKAR 638
Query: 556 LKELESQ---VSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSL 612
L+ LES V+ KE + L E E++ D ++N T A KE +L
Sbjct: 639 LRSLESLHSFVAAATKELMWLNEKEEEEV--GFDWSDRN--------TNMTAKKESYSAL 688
Query: 613 TQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLK--HPPAP 670
+ E EK++ ++L+ G LL+ HP P
Sbjct: 689 MRELELKEKKI------------------------------KELQNAGDRLLREDHPARP 718
Query: 671 AEPSSDLASKLREAEETQSTLQAECD--------QYRSILAETEGMLRDLQKSVEEEEQV 722
S A + + + Q E Q+ S + E EG L+ LQ+++ +
Sbjct: 719 TVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSC 778
Query: 723 WRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAE 782
R+ TV LE++++ + E E Q+ E+ HL ++ A +
Sbjct: 779 DRS-------------ATVTRLEDLLQDAQDEKE---QLNEYKGHLSGLAKRAKAVVQLK 822
Query: 783 CQNYAKEVAGLRQLLLESQSQLDAAKSEAQ-KQSDELALV-RQQLSEMKSHVEDGDIAGA 840
++ A + G LL + D + E + DE LV Q S K G A
Sbjct: 823 PRHPAHPMRGRLPLL----AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAV 878
Query: 841 PASSPEAPPAEQDP----------------------VQLKTQLEWTEAILEDEQTQRQKL 878
P+ PP Q+ V +K+ L W +++ D Q R
Sbjct: 879 PSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW-QSLRRDVQLIRSWS 937
Query: 879 TAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQ 938
A F + R +L L S+ ++RL E++ S LQ
Sbjct: 938 LATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQ 997
Query: 939 ELLKTTQEQLAREK--DTVKKLQEQLEKAE 966
L + QE+ ++ +K ++ QLE E
Sbjct: 998 SLEQGAQEESRCQRCISELKDIRLQLEACE 1027
Score = 37.7 bits (86), Expect = 0.053
Identities = 109/534 (20%), Positives = 200/534 (37%), Gaps = 48/534 (8%)
Query: 39 EEALANQR---KEMAKTHHQKVEK------------KKKEKTVEKKGKTKKKEEKPNGKI 83
EE LA QR ++M K Q V++ ++KE E+ + ++ +E+ ++
Sbjct: 2325 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2384
Query: 84 PDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKE 143
+ T+ E R + ++ + + VA ++ A +E K ++
Sbjct: 2385 AEETQGFQRTL---EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2441
Query: 144 KKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKK 203
+K+ + E A V +Q L + + + R E K + AK +
Sbjct: 2442 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2501
Query: 204 KGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGI---IQDTWHKATQKGD 260
+ L + L + S + + +R IE EKA + QD KA Q +
Sbjct: 2502 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE--QEKAKLEQLFQDEVAKAQQLRE 2559
Query: 261 PVAILKRQLEEKEKLLATEQEDAA----VAKSKLRELNKEM-AAEKAKAAAGEAKVKKQL 315
++Q+E++ + L E+A A+ +R +E+ E+ + E ++
Sbjct: 2560 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2619
Query: 316 VAREQ-EITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRD 374
REQ ++ Q R ++ E V Q K +GP + + + R
Sbjct: 2620 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRK 2679
Query: 375 ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVL 434
Q + EL +L Q + V + + + E VR Q R ++ + L
Sbjct: 2680 VSAQRLQEAGILSAEELQRLAQGHTTVDE--LARREDVRHYLQGRSSIAGLLLKATNEKL 2737
Query: 435 QLQASHRESEEALQKRLDEVSRELCHTQSSHAS---------LRADAEKAQEQQQQMAEL 485
+ A ALQ++L L ++ AS R +A ++ EL
Sbjct: 2738 SVYA-------ALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPEL 2790
Query: 486 HSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTER-IRSIEALLEAGQARD 538
H KL S+E V + +G L +A + + E IR +EA + G D
Sbjct: 2791 HHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVID 2844
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 129 bits (325), Expect = 1e-29
Identities = 198/840 (23%), Positives = 353/840 (42%), Gaps = 131/840 (15%)
Query: 225 GSMVFNEGEAQRL----IEILSEKAGII------QDTWHKATQKGDPVAILKRQLEEKEK 274
G++ E + Q L + I EK + QD A ++ + K QLE K K
Sbjct: 910 GALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVK 969
Query: 275 LLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYR 334
L+ ED E+N ++AA + K ++KK + + ++T +A
Sbjct: 970 ELSERLEDE-------EEVNADLAARRRKLEDECTELKKDI--DDLKLTLAKAE------ 1014
Query: 335 EHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQN--AELA 392
KE Q + K++ L E++ + +ARL +E L++A QA ++++++ + L
Sbjct: 1015 ---KEKQATENKVKNLTEEMA-ALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALT 1070
Query: 393 KLRQELSKVSKEL---VEKSEAVRQD-EQQRKALEAKAAAFEKQVLQLQASHRESEEALQ 448
K + L + ++L +E+ + +R D E+ ++ LE ++ V ++ EE L+
Sbjct: 1071 KAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLK 1130
Query: 449 KRLDEVSREL----------CHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRS 498
K+ E+S+ Q L+A AE+ +E+ + ++++ AE
Sbjct: 1131 KKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAAR 1190
Query: 499 KCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLK- 557
+ EELS +L+EA ++ E R EA E G+ R + A + EA R K
Sbjct: 1191 ELEELS---ERLEEAGGASAGQREGCRKREA--ELGRLRRELEEAALRHEATVAALRRKQ 1245
Query: 558 -----ELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSL 612
EL QV L++ +L + + +++ +DL A A+AE+ C+ L
Sbjct: 1246 AEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQL 1305
Query: 613 TQAK---EESEKQLCLIEAQ----------------TMEALLALLPELSVLAQQNYTEWL 653
++AK EE ++QL Q E L++ L LA Q+ E
Sbjct: 1306 SEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELR 1365
Query: 654 QDLKE--KGPTLLKHPPAPAEPSSDLASKLREAE-ETQSTLQ-------AECDQYRSILA 703
+ L+E K + L H DL + E E E Q+ LQ AE Q+RS
Sbjct: 1366 RQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRS-KY 1424
Query: 704 ETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELES------ 757
E + + R + +EE ++ ++ AEE ++ + LE+ +L+ E E
Sbjct: 1425 EADAIQR--TEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELE 1482
Query: 758 ---------------SDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQS 802
++ E E E+++ + AA E + E+ LR E+
Sbjct: 1483 RATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALE 1542
Query: 803 QLDAAKSEAQKQSDELALVRQQLS---------EMKSHVEDGDIAGAPASSPEAPPA--E 851
L+ K E + +E++ + Q+S E +G+ + A+ EA A
Sbjct: 1543 ALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALEL 1602
Query: 852 QDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETE 911
++ L+ QLE ++ E + +KL + EE Q +E L+ + E+
Sbjct: 1603 EETKTLRIQLELSQVKAEVD----RKLAEKDEECANLRRNHQRAVESLQASLDAETRARN 1658
Query: 912 EASQLKERLEKE-KKLTSDLG---RAATRLQELLKTTQEQLARE---KDTVKKLQEQLEK 964
EA +LK+++E + L LG R AT Q + Q QL E +D ++L +L +
Sbjct: 1659 EALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHE 1718
Score = 126 bits (316), Expect = 1e-28
Identities = 193/892 (21%), Positives = 382/892 (42%), Gaps = 102/892 (11%)
Query: 132 LASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQ 191
LA + K+K+ E KV + ++++ S+ LT + L+ A ++ A E +
Sbjct: 1010 LAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQA---EEDRV 1066
Query: 192 EAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDT 251
A K K +++ D + L K + T + EG+ + E +++ A Q
Sbjct: 1067 SALTKAKLRLEQQ-VEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQL 1125
Query: 252 WHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKV 311
K +K ++ L ++E+++ L A Q+ +++ EL +E+ AE+A A+V
Sbjct: 1126 EEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERA----ARARV 1181
Query: 312 KKQLVAREQEITAVQARMQ------ASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARL 365
+KQ +E+ + R++ A RE ++ + G++R E+ +A L
Sbjct: 1182 EKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAAL 1241
Query: 366 QQENSILRDALNQ---ATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
+++ + L + + +V K E ++LR E+ ++ + + A E+ +
Sbjct: 1242 RRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTY 1301
Query: 423 EAKAAAFEKQVLQLQ---ASHRESEEALQKRLDEVSRELCHTQSSHASL---RADAEKAQ 476
E + + + +V +LQ A LQ E+SR L + + L +A A ++
Sbjct: 1302 EDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSL 1361
Query: 477 EQQQQMAELHSKLQSSEAE----VRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLE 532
E+ ++ E SK +S+ A +R C+ L H + EA+AE +L + + E
Sbjct: 1362 EELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANA-----E 1416
Query: 533 AGQARDAQDVQASQAEADQQQT------RLKELESQVSGLEKEAIELREAVEQQKVKNND 586
Q R + A Q + ++ RL+E E V + L +A + + ++ D
Sbjct: 1417 VAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESED 1476
Query: 587 LREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVL-- 644
+ + +A A A ++ + +L + + + E+ +EA E+ L EL L
Sbjct: 1477 VTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESR-GLGTELFRLRH 1535
Query: 645 AQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAE 704
+ E L+ LK + L + + S ++E E+T+ L+ E + ++ L E
Sbjct: 1536 GHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEE 1595
Query: 705 TEGMLRDLQKSVEEEEQVWRAKVGA------AEEELQKSRVTVKHLEEIVEKLKGELESS 758
EG L +L+++ Q+ ++V A AE++ + + + H + VE L+ L++
Sbjct: 1596 AEGAL-ELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNH-QRAVESLQASLDAE 1653
Query: 759 DQVREHTSHLEAELE---KHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQS 815
+ R L+ ++E + A E +L+ + A + E Q+ +
Sbjct: 1654 TRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLA 1713
Query: 816 DEL-----------ALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWT 864
EL +L+ +L E+++ +E G+ + A EQ+ ++ +L
Sbjct: 1714 AELHEQAQALERRASLLAAELEELRAALEQGERSRRLA--------EQELLEATERLNLL 1765
Query: 865 EAILEDEQTQRQKLTA-------EFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLK 917
+ Q++KL A E EEA +E+ +K T +A+ +
Sbjct: 1766 HSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAIT----------DAAMMA 1815
Query: 918 ERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAEDGS 969
E L+KE+ ++ L E +K T EQ TV++LQ +LE+AE +
Sbjct: 1816 EELKKEQDTSAHL--------ERMKKTLEQ------TVRELQARLEEAEQAA 1853
Score = 121 bits (303), Expect = 4e-27
Identities = 177/782 (22%), Positives = 342/782 (43%), Gaps = 101/782 (12%)
Query: 265 LKRQLEEKEKLLATEQE---DAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQE 321
L++Q+E+ E L E++ D AK KL K A AA + +++++L ++ E
Sbjct: 1076 LEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSE 1135
Query: 322 ITAVQARMQASY---REHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQ 378
++ + R++ + K++++LQ + L+E+LE AR++++ + L +
Sbjct: 1136 LSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELE-AERAARARVEKQRAEAARELEE 1194
Query: 379 ATSQVES-------------KQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAK 425
+ ++E K+ AEL +LR+EL + + A+R RK E
Sbjct: 1195 LSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALR-----RKQAEG- 1248
Query: 426 AAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEK-AQEQQQQMAE 484
AA +QV LQ ++ E+ + EV +L + +A AEK + + Q++E
Sbjct: 1249 AAELGEQVDSLQRVRQKLEKEKSELRMEVD-DLAANVETLTRAKASAEKLCRTYEDQLSE 1307
Query: 485 LHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQA 544
K++ E++ + + S G+LQ E S+L E + + L G+A AQ ++
Sbjct: 1308 AKIKVE----ELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEE 1363
Query: 545 SQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQA 604
+ + +++ L V L + LRE E++ +L+ KA +A
Sbjct: 1364 LRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSK 1423
Query: 605 CKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLL 664
+ T+ EE++K+L L + E + A + S L + LQ E L
Sbjct: 1424 YEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLR--LQTESEDVTLEL 1481
Query: 665 KHPPAPAEP--------SSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSV 716
+ + A L + R+ EE Q L+A + R + E + ++++
Sbjct: 1482 ERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEAL 1541
Query: 717 EEEEQVWRAKVGAAEE----------------ELQKSRVTVK----HLEEIVEKLKGELE 756
E E + R EE EL+K++ ++ ++ +E+ +G LE
Sbjct: 1542 EALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALE 1601
Query: 757 SSD----QVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLES-QSQLDAAKSEA 811
+ +++ S ++AE+++ +A EC N + Q +ES Q+ LDA E
Sbjct: 1602 LEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRN----HQRAVESLQASLDA---ET 1654
Query: 812 QKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDE 871
+ +++ L L + +M+ + D ++ A+ +A A+ ++ QL+ +A ++E
Sbjct: 1655 RARNEALRLKK----KMEGDLNDLELQLGHATR-QATEAQAATRLMQAQLKEEQAGRDEE 1709
Query: 872 QTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSE------TEEASQLKER------ 919
Q +L + + + A L ELE+LR A LE E +E + ER
Sbjct: 1710 QRLAAELHEQAQALERRASLLAAELEELRAA--LEQGERSRRLAEQELLEATERLNLLHS 1767
Query: 920 -----LEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTV---KKLQEQLEKAEDGSSS 971
L ++KKL +DL + + ++E + +E + K + + E+L+K +D S+
Sbjct: 1768 QNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAH 1827
Query: 972 KE 973
E
Sbjct: 1828 LE 1829
Score = 118 bits (295), Expect = 3e-26
Identities = 195/890 (21%), Positives = 355/890 (39%), Gaps = 127/890 (14%)
Query: 127 MPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKE--GRNTDVAQ 184
+ QE +A + +DK++ E+K+ K + +S + ++ A ++ KE R ++ +
Sbjct: 1110 LTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEE 1169
Query: 185 SPEA--------PKQEAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQR 236
EA KQ A A ++ + +A G E E R
Sbjct: 1170 ELEAERAARARVEKQRAEAARELEELSERLEEAGG-------ASAGQREGCRKREAELGR 1222
Query: 237 LIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKE 296
L L E A H+AT VA L+R+ E L + + + KL + E
Sbjct: 1223 LRRELEEAA-----LRHEAT-----VAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSE 1272
Query: 297 MAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLEN 356
+ E L A + +T +A + R + ++ + + K+ LQ QL +
Sbjct: 1273 LRME-----------VDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLAD 1321
Query: 357 GPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDE 416
+TQ RLQ E+ L L + + S+ + A Q L ++ ++L E+S+A
Sbjct: 1322 A-STQRGRLQTESGELSRLLEEKECLI-SQLSRGKALAAQSLEELRRQLEEESKA----- 1374
Query: 417 QQRKALEAKAAAFEKQVLQLQASHRESEEA---LQKRLDEVSRELCHTQSSHASLRADA- 472
+ AL A L+ H E EA LQ+ L + + E+ +S + ADA
Sbjct: 1375 --KSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKY---EADAI 1429
Query: 473 EKAQEQQQQMAELHSKLQSSEAEV---RSKCEELSGLHGQLQEARAENSQLTERIRSIEA 529
++ +E ++ +L +LQ +E V +KC L +LQ + + ER S A
Sbjct: 1430 QRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAA 1489
Query: 530 LLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELR-------EAVEQQKV 582
L+ Q + ++ + + ++ Q L+ + + GL E LR EA+E K
Sbjct: 1490 ALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKR 1549
Query: 583 KNNDLREK----------NWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTME 632
+N +L+E+ + K+++ L ++A + + + A EE+E L L E +T+
Sbjct: 1550 ENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLR 1609
Query: 633 ALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQ 692
L L +K + L AE + A+ R + +LQ
Sbjct: 1610 IQLE----------------LSQVKAEVDRKL------AEKDEECANLRRNHQRAVESLQ 1647
Query: 693 AECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLK 752
A D A E + L+K +E + ++G A + +++ + ++
Sbjct: 1648 ASLD--AETRARNEAL--RLKKKMEGDLNDLELQLGHATRQATEAQAATR-------LMQ 1696
Query: 753 GELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQ 812
+L+ R+ L AEL + A A E+ LR L + + A+ E
Sbjct: 1697 AQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELL 1756
Query: 813 KQSDELALVRQQ---LSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILE 869
+ ++ L L+ Q L K +E D+A EA ++ + + A++
Sbjct: 1757 EATERLNLLHSQNTGLLNQKKKLE-ADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMA 1815
Query: 870 DEQTQRQKLTAEFEE----AQTSACRLQEELEKLRTAG---------PLESSETEEASQL 916
+E + Q +A E + + LQ LE+ A LE+ E ++L
Sbjct: 1816 EELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAEL 1875
Query: 917 KERLEKEKKLTSDLGRAATRLQELLKTTQE---QLAREKDTVKKLQEQLE 963
+K + + + R++EL +E LAR +D V KLQ +++
Sbjct: 1876 DAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVK 1925
Score = 102 bits (254), Expect = 2e-21
Identities = 132/550 (24%), Positives = 240/550 (43%), Gaps = 60/550 (10%)
Query: 450 RLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKL--------------QSSEAE 495
R + EL ++ LR A+ ++Q++ E H + Q + A+
Sbjct: 890 RSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLAD 949
Query: 496 VRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQ----------ARDAQDVQAS 545
+C L QL+ E S+ E + A L A + +D D++ +
Sbjct: 950 AEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLT 1009
Query: 546 QAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQAC 605
A+A++++ + E++V L +E L E+V + + L+E + +A+ L QA
Sbjct: 1010 LAKAEKEK---QATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDL----QAE 1062
Query: 606 KEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLK 665
++++ +LT+AK E+Q+ + +E L +L + ++ + DLK ++
Sbjct: 1063 EDRVSALTKAKLRLEQQV-----EDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVAD 1117
Query: 666 HPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRA 725
A+ L KL++ + S L + + + A+ + +++LQ EE E+ A
Sbjct: 1118 ----AAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEA 1173
Query: 726 KVGAAEEELQKSRV-TVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQ 784
+ AA ++K R + LEE+ E+L+ +S RE EAEL +
Sbjct: 1174 E-RAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAAL 1232
Query: 785 NYAKEVAGLRQLLLESQS----QLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGA 840
+ VA LR+ E + Q+D+ + QK E + +R ++ ++ ++VE + A
Sbjct: 1233 RHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVE--TLTRA 1290
Query: 841 PASSPEAPPAEQDPV-QLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELE-- 897
AS+ + +D + + K ++E + L D TQR +L E E RL EE E
Sbjct: 1291 KASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELS----RLLEEKECL 1346
Query: 898 --KLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTV 955
+L L + EE L+ +LE+E K S L A L+ +EQ E +
Sbjct: 1347 ISQLSRGKALAAQSLEE---LRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQ 1403
Query: 956 KKLQEQLEKA 965
+LQ L KA
Sbjct: 1404 AELQRLLSKA 1413
Score = 72.8 bits (177), Expect = 1e-12
Identities = 91/392 (23%), Positives = 168/392 (42%), Gaps = 64/392 (16%)
Query: 625 LIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREA 684
L AQ E L AL EL L L + K L + + + +DLA +L+
Sbjct: 889 LRSAQAEEELAALRAELRGLRGA-----LAAAEAKRQELEETHVSITQEKNDLALQLQAE 943
Query: 685 EETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHL 744
++ + + C + EG +++L + +E+EE+V A + A +L+ L
Sbjct: 944 QDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEV-NADLAARRRKLEDE---CTEL 999
Query: 745 EEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQL 804
++ ++ LK L +++ ++ T + L + MAA KE L++ ++ L
Sbjct: 1000 KKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDL 1059
Query: 805 DA----------AKSEAQKQSDELALVRQQLSEMKSHVE------DGDIAGAPASSPEAP 848
A AK ++Q ++L +Q +++ E +GD+ +
Sbjct: 1060 QAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDL---KLTQESVA 1116
Query: 849 PAEQDPVQLKTQLEWTEAIL-------EDEQTQRQKLTAEFEEAQTSACRLQEELEKLRT 901
A QD QL+ +L+ ++ L EDEQ ++ + +E Q A L+EELE R
Sbjct: 1117 DAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERA 1176
Query: 902 AGPLESSETEEAS----QLKERLEKE-----------KKLTSDLGRAATRLQE------- 939
A + EA+ +L ERLE+ +K ++LGR L+E
Sbjct: 1177 ARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEA 1236
Query: 940 ---LLKTTQ----EQLAREKDTVKKLQEQLEK 964
L+ Q +L + D++++++++LEK
Sbjct: 1237 TVAALRRKQAEGAAELGEQVDSLQRVRQKLEK 1268
Score = 65.9 bits (159), Expect = 2e-10
Identities = 64/319 (20%), Positives = 141/319 (44%), Gaps = 30/319 (9%)
Query: 683 EAEETQSTLQAECDQYRSILAETEGMLRDLQK---SVEEEEQVWRAKVGAAEEELQKSRV 739
+AEE + L+AE R LA E ++L++ S+ +E+ ++ A ++ L +
Sbjct: 893 QAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEE 952
Query: 740 TVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLE 799
L + +L+G+++ + E + A+L EC K++ L+ L +
Sbjct: 953 RCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAK 1012
Query: 800 SQSQLDAAKSEAQKQSDELALVRQ---QLSEMKSHVED------GDIAG----APASSPE 846
++ + A +++ + ++E+A + + +L++ K +++ GD+ A +
Sbjct: 1013 AEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKA 1072
Query: 847 APPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLE 906
EQ L+ LE + + D + ++KL + + Q S ++ ++L +
Sbjct: 1073 KLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKK 1132
Query: 907 SSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREK-----------DTV 955
S E SQL R+E E+ L + + + LQ + +E+L E+ +
Sbjct: 1133 DS---ELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAA 1189
Query: 956 KKLQEQLEKAEDGSSSKEG 974
++L+E E+ E+ + G
Sbjct: 1190 RELEELSERLEEAGGASAG 1208
Score = 65.5 bits (158), Expect = 2e-10
Identities = 119/562 (21%), Positives = 222/562 (39%), Gaps = 113/562 (20%)
Query: 263 AILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEI 322
A L+ Q E ++ L E+ +A A ++ + E A E+ + E +++++L A ++E
Sbjct: 1466 AKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQ--EEEMQRELEAAQRES 1523
Query: 323 TAVQA---RMQASYREHVKEVQQLQGKIRTLQEQLEN--------GPNTQLAR-----LQ 366
+ R++ + E ++ ++ L+ + + LQE++ + G + Q L+
Sbjct: 1524 RGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALE 1583
Query: 367 QENSILRDALNQATSQVESKQNAELA---KLRQELSKVSKELVEKSEAV--------RQD 415
E S ++ AL +A +E ++ L +L Q ++V ++L EK E R
Sbjct: 1584 GEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAV 1643
Query: 416 EQQRKALEAKAAAFE------------------------KQVLQLQASHRESEEALQKRL 451
E + +L+A+ A +Q + QA+
Sbjct: 1644 ESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAA------------ 1691
Query: 452 DEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQ 511
T+ A L+ + E+Q+ AELH + Q+ E EL L L+
Sbjct: 1692 ---------TRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALE 1742
Query: 512 EARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSG------ 565
+ + +L E + LLEA + RL L SQ +G
Sbjct: 1743 QGE-RSRRLAE-----QELLEATE-------------------RLNLLHSQNTGLLNQKK 1777
Query: 566 -LEKEAIELREAVEQQKVKNNDLREKNWKAM-EALATAEQACKEKLHSLTQAKEESEKQL 623
LE + +L VE+ + + EK KA+ +A AE+ KE+ + E +K L
Sbjct: 1778 KLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQ--DTSAHLERMKKTL 1835
Query: 624 CLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLRE 683
QT+ L A L E A + + +Q L+ K L A + ++ +R+
Sbjct: 1836 ----EQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRK 1891
Query: 684 AEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKH 743
E L + ++ R LA + ++ LQ V+ ++ + A L K R
Sbjct: 1892 HERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHE 1951
Query: 744 LEEIVEKLKGELESSDQVREHT 765
L++ E+ ++++R T
Sbjct: 1952 LDDAEERADMAETQANKLRART 1973
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 129 bits (324), Expect = 1e-29
Identities = 193/874 (22%), Positives = 379/874 (43%), Gaps = 118/874 (13%)
Query: 132 LASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQ 191
LA + + ++KE + K+ +S++ + + + A LET ++ S E K+
Sbjct: 881 LARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKE 940
Query: 192 EAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSE-KAGIIQD 250
A A + + + + G + ST ++ E EA+++ L +A +++
Sbjct: 941 PARAGDR---QPEWLEEQQG------RQFCSTQAALQAMEREAEQMGNELERLRAALMES 991
Query: 251 TWHKATQKGDPVAILKRQLEEKEKL---LATEQEDAAVAKSKLRELNKEMAAEKAKAAAG 307
+ ++G + R +E+ + LA E+ A + +L+ E E A
Sbjct: 992 QGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEA 1051
Query: 308 EAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQ 367
A + ++QE+ A+++ +KE+++L+ ++ L+EQL A+ ++
Sbjct: 1052 LAHALTEKEGKDQEL----AKLRGLEAAQIKELEELRQTVKQLKEQL--------AKKEK 1099
Query: 368 ENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAA 427
E++ A ++A + E +L LR E+SK+ ++ ++ E Q + ++LEA+ A
Sbjct: 1100 EHASGSGAQSEAAGRTEPT-GPKLEALRAEVSKLEQQCQKQQE---QADSLERSLEAERA 1155
Query: 428 AFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRA----------DAEKAQE 477
+ +A + E LQ +L+E ++EL H+QS+ AS + D KA++
Sbjct: 1156 S--------RAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAED 1207
Query: 478 Q-QQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQA 536
+ + Q+A + + + + S EE+S L+ Q+ E E+ +L R + A E Q
Sbjct: 1208 EWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELK---RLVMAESEKSQK 1264
Query: 537 RDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREK---NWK 593
+ + ++ QAE R E + S L +E LRE E+Q+V + +LR++ +
Sbjct: 1265 LEER-LRLLQAETASNSARAAE---RSSALREEVQSLREEAEKQRVASENLRQELTSQAE 1320
Query: 594 AMEALATAEQACKEKLHSLTQAK-----EESEKQLCLIEAQTMEALLALLPELSVLAQQN 648
E L +A +EK QA E + Q + E + L L A++
Sbjct: 1321 RAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKR 1380
Query: 649 YTEWLQDLKEKGPTL---LKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYR---SIL 702
+ E L+ K+ L L L K+ E E T L+AE Y S+L
Sbjct: 1381 HREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSML 1440
Query: 703 AETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVR 762
+ G+L + + + E RA +G E++ + K+++E+ VR
Sbjct: 1441 KKAHGLLAEENRGLGE-----RANLGRQFLEVELDQAREKYVQELAA-----------VR 1484
Query: 763 EHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVR 822
AE+++ + + E + + G + +LE + + + + Q ++L + +
Sbjct: 1485 ADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQ 1544
Query: 823 QQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEF 882
+ E VE+ L +L ++ + +Q + + + A+
Sbjct: 1545 R---EQTKQVEE----------------------LSKKLADSDQASKVQQQKLKAVQAQG 1579
Query: 883 EEAQTSACRLQEELEKLRTAGPLESSETEEASQ-LKERLEKEKKLTSDLGRAATRLQELL 941
E+Q A RLQ +L +L+ + S+ E+A++ K ++EK K + LQE L
Sbjct: 1580 GESQQEAQRLQAQLNELQA----QLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL 1635
Query: 942 KTTQEQLAREKDTVKKLQEQL--EKAEDGSSSKE 973
++ EQL +E ++ E+L E + G +KE
Sbjct: 1636 RSL-EQLQKENKELRAEAERLGHELQQAGLKTKE 1668
Score = 129 bits (323), Expect = 2e-29
Identities = 167/727 (22%), Positives = 319/727 (43%), Gaps = 52/727 (7%)
Query: 265 LKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITA 324
L+ +L E KLL ++DA +A + R + EK A+ E K ++L + + +T
Sbjct: 233 LELELAENRKLLT--EKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTM 290
Query: 325 VQARMQASYREHVKEVQQLQGKIRTLQEQLENGP-NTQLARLQQENSILRDALNQATSQV 383
++ E Q+ KI L E ENG + +L L+DALN+ T +
Sbjct: 291 RLHETLKQCQDLKTEKSQMDRKINQLSE--ENGDLSFKLREFASHLQQLQDALNELTEE- 347
Query: 384 ESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQAS-HRE 442
SK E + + +L K ++ + + E++ + L+ K + E+ + QLQ + +E
Sbjct: 348 HSKATQEWLEKQAQLEKELSAALQDKKCL---EEKNEILQGKLSQLEEHLSQLQDNPPQE 404
Query: 443 SEEALQK--RLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKC 500
E L +L+ + +E +++ L+A E + ++ Q +KL + +
Sbjct: 405 KGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQ---EAKLLAERGHFEEEK 461
Query: 501 EELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELE 560
++LS L LQ + + SQ E +E +A AR V + +E +++ +
Sbjct: 462 QQLSSLITDLQSSISNLSQAKE---ELEQASQAHGARLTAQVASLTSELTTLNATIQQQD 518
Query: 561 SQVSGLEKEAIE----LREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAK 616
+++GL+++A E L + ++QQ+ + LR + + +L EQ KE +
Sbjct: 519 QELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR 578
Query: 617 EESEKQLCLIEAQTMEALL----ALLPELSVLAQQN------YTEWLQDLKEKGPTLLKH 666
++ +QL A+ EA L A L +L L ++ + LQ E +
Sbjct: 579 QDHAQQLA-TAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTS 637
Query: 667 PPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAK 726
++L+ K+ E + T + E + ++ +AE E LR Q+ E+E+V + K
Sbjct: 638 VTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEK 697
Query: 727 VGAAEEELQKSRVTVKHLE-EIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQN 785
+E+LQ + ++K + + E+ + ++ ++ + S L+AE + E +
Sbjct: 698 -DQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKE 756
Query: 786 YAKEVAGLRQLLLESQSQLDAAKSEAQKQSDEL--ALVRQQLSEMKSHVEDGDIAG---- 839
+E AG + L Q +A ++E + EL A+ Q +E + ++A
Sbjct: 757 LEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRER 816
Query: 840 -APASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEK 898
+ EA QL T E E ++ Q ++K+ ++ R Q EL +
Sbjct: 817 YEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAE 876
Query: 899 LRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKL 958
L ++ Q++E+ + +KL DL + LQE + T +++AR + V+K
Sbjct: 877 ------LHANLARALQQVQEKEVRAQKLADDL----STLQEKMAATSKEVARLETLVRKA 926
Query: 959 QEQLEKA 965
EQ E A
Sbjct: 927 GEQQETA 933
Score = 127 bits (319), Expect = 5e-29
Identities = 177/783 (22%), Positives = 331/783 (42%), Gaps = 130/783 (16%)
Query: 264 ILKRQLEEKEKLLATEQEDAAVAKSKLRE--LNKE-MAAEKAKAAAGEAKVKKQLVAREQ 320
IL+ +L + E+ L+ Q++ K ++ L E + E A AA +++ ++ E
Sbjct: 382 ILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLET 441
Query: 321 EITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQAT 380
E +A++ A +E QQL I LQ + N L+QA
Sbjct: 442 ERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISN-------------------LSQAK 482
Query: 381 SQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASH 440
++E A A+L +++ ++ EL + ++Q +Q+ L+ +A + Q+ Q
Sbjct: 483 EELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQ 542
Query: 441 RESEEALQKRLDEVSRELCH--------------TQSSHASLRADAEKAQEQQQQMAELH 486
++ + L+ +++++S L T+ HA A A A+E++ + E
Sbjct: 543 EQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATA--AEEREASLRERD 600
Query: 487 SKLQSSEAEVRSKCEELSGLHGQLQ--------------EARAENSQLTERIRSIEALLE 532
+ L+ EA + K +L L QLQ +A+ E ++L+ ++ ++A +E
Sbjct: 601 AALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVE 660
Query: 533 AGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNW 592
++ E + Q ++ ELE Q+ +++A E +E V Q+K + L+E+
Sbjct: 661 T-----------ARQEQHEAQAQVAELELQLRSEQQKATE-KERVAQEK---DQLQEQLQ 705
Query: 593 KAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEW 652
E+L + + +E+ A EE ++ + ++A+T L E ++ E
Sbjct: 706 ALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRS-----LVEQHKRERKELEEE 760
Query: 653 LQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDL 712
K L + A + L +L EA Q T ++EC+Q +A D
Sbjct: 761 RAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDS 820
Query: 713 QKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKG-ELESSDQVREHTSHLEAE 771
Q+ + +++ ++ +EE +K+R + L+E EK+ G E S Q+ + L AE
Sbjct: 821 QQEEAQYGAMFQEQLMTLKEECEKAR---QELQEAKEKVAGIESHSELQISRQQNEL-AE 876
Query: 772 LEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSH 831
L ++A A + Q KEV Q L + S L + K+ L + ++ E +
Sbjct: 877 LHANLARALQQVQE--KEVRA--QKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQE- 931
Query: 832 VEDGDIAGAPASSPEAPPA--------------------EQDPVQLKTQLEWTEAILEDE 871
++ PA + + P E++ Q+ +LE A L +
Sbjct: 932 TASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMES 991
Query: 872 QTQRQ-----------KLTAEFEEAQT-------SACRLQEELEKLRTAGPLESSETEEA 913
Q Q+Q +LT E AQ + L+ L+ +E + +EA
Sbjct: 992 QGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEA 1051
Query: 914 --SQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAEDGSSS 971
L E+ K+++L G A +++EL E+L + TVK+L+EQL K E +S
Sbjct: 1052 LAHALTEKEGKDQELAKLRGLEAAQIKEL-----EEL---RQTVKQLKEQLAKKEKEHAS 1103
Query: 972 KEG 974
G
Sbjct: 1104 GSG 1106
Score = 127 bits (318), Expect = 7e-29
Identities = 220/1022 (21%), Positives = 430/1022 (42%), Gaps = 142/1022 (13%)
Query: 35 ETSYEEAL---ANQRKEMAKTHHQKVEKKKKE-KTVEKKGKTKKKEEKPNGKIPD-HDPA 89
ET +EA AN + A+ + E+ ++E K + ++G ++++++ + I D
Sbjct: 416 ETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSI 475
Query: 90 PNVTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEK---LASSPKDKKKKEKKV 146
N++ E +A A Q + + + T+ A Q++ LA + K+K+ ++
Sbjct: 476 SNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQL 535
Query: 147 AKV----EPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSK 202
A+ E A + + ++ L+S KE + +VA+ EA +Q+ + + ++
Sbjct: 536 AQTLQQQEQASQGLRHQVEQLSSSLK-----QKEQQLKEVAEKQEATRQDHAQQLATAAE 590
Query: 203 KKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKA----TQK 258
++ + L + E E +EIL ++ + + A TQ
Sbjct: 591 EREASLRERDAALKQLEAL---------EKEKAAKLEILQQQLQVANEARDSAQTSVTQA 641
Query: 259 GDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEA------KVK 312
A L R++EE + + T +++ A++++ EL ++ +E+ KA E +++
Sbjct: 642 QREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQ 701
Query: 313 KQLVAREQEITAVQARMQASYR-------EHVKEVQQLQGKIRTLQEQLENGPNTQLARL 365
+QL A ++ + + ++ R E + + +L+ + R+L EQ + + L
Sbjct: 702 EQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKR----ERKEL 757
Query: 366 QQENSILRDALNQATSQVESKQNAELAKLRQELSKVS----------KELVEKSEAVRQD 415
++E + R L Q+ AE LR+EL++ ++LV++ A R+
Sbjct: 758 EEERAG-RKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRER 816
Query: 416 EQQRKALEAK-AAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEK 474
+ + EA+ A F++Q++ L+ ++ + LQ+ ++V+ SH+ L+
Sbjct: 817 YEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGI-----ESHSELQIS--- 868
Query: 475 AQEQQQQMAELHSKL-----QSSEAEVRSK--CEELSGLHGQLQEARAENSQLTERIR-- 525
QQ ++AELH+ L Q E EVR++ ++LS L ++ E ++L +R
Sbjct: 869 --RQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKA 926
Query: 526 -------SIEALLEAGQARDAQDVQASQAEADQ---QQTRLKELESQVSGLEKEAIELRE 575
S E + E +A D Q + + Q Q L+ +E + + E LR
Sbjct: 927 GEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRA 986
Query: 576 AV-----EQQKVKNNDLRE------KNWKAMEALATAEQACKEKLHSLTQAKEESEKQLC 624
A+ +QQ+ + RE + +A LA + A E L A E +
Sbjct: 987 ALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFA 1046
Query: 625 LIEAQTMEAL---------LALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSS 675
++ AL LA L L + E Q +K+ L K A S
Sbjct: 1047 TLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSG 1106
Query: 676 DLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQ 735
+ E T L+A + AE + + QK E+ + + E L+
Sbjct: 1107 AQSEAAGRTEPTGPKLEA-------LRAEVSKLEQQCQKQQEQADSL--------ERSLE 1151
Query: 736 KSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQ 795
R + + +E L+G+LE Q H+ A ++ +AA + Q+++K
Sbjct: 1152 AERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAED---- 1207
Query: 796 LLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPV 855
E ++Q+ + EA++++ ++ + +++S + V + + G AE +
Sbjct: 1208 ---EWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKE--GESKELKRLVMAESEKS 1262
Query: 856 QLKTQLEWTEAILEDEQTQRQKLTAEFEEA-QTSACRLQEELEKLRTAG----PLESSET 910
Q +LE +L+ E AE A + L+EE EK R A +S+
Sbjct: 1263 Q---KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQA 1319
Query: 911 EEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAEDGSS 970
E A +L + L+ ++ +A + LQ L T+ + L E K L +QL+ AE ++
Sbjct: 1320 ERAEELGQELKAWQEKFFQKEQALSTLQ-LEHTSTQALVSELLPAKHLCQQLQ-AEQAAA 1377
Query: 971 SK 972
K
Sbjct: 1378 EK 1379
Score = 94.0 bits (232), Expect = 6e-19
Identities = 159/681 (23%), Positives = 282/681 (41%), Gaps = 125/681 (18%)
Query: 129 QEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEA 188
QE LA + +K+ K++++AK+ ++ + ++ L R T +
Sbjct: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEEL--------------RQTVKQLKEQL 1094
Query: 189 PKQEAPAKKKSGSKKK--GPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAG 246
K+E SG++ + G + GP + VS + E + Q+ E
Sbjct: 1095 AKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKL------EQQCQKQQEQADSLER 1148
Query: 247 IIQDTWHKATQKGDPVAILKRQLEEK-------EKLLATEQEDAAVAKSKLRELNKEMAA 299
++ ++ + L+ QLEEK + LA+ Q + A ++K+++ +K
Sbjct: 1149 SLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE 1208
Query: 300 EKAKAAAG--EAKVKKQLVAREQEITAVQARMQASYREHVKEVQQL----QGKIRTLQEQ 353
KA+ A G EA+ K L++ +E ++ R KE+++L K + L+E+
Sbjct: 1209 WKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEER 1268
Query: 354 L-----ENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELS-------KV 401
L E N+ AR + +S LR+ + + E KQ LRQEL+ ++
Sbjct: 1269 LRLLQAETASNS--ARAAERSSALREEVQSLREEAE-KQRVASENLRQELTSQAERAEEL 1325
Query: 402 SKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQL-QASH-----RESEEALQKRLDEVS 455
+EL E Q EQ L+ + + + V +L A H + + A +KR E
Sbjct: 1326 GQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHRE-- 1383
Query: 456 RELCHTQSSHASLRADAEKAQEQ-------QQQMAELHSKLQSSEAEVRSKCEELSGL-- 506
EL ++ + LRA+ +AQ + +Q++AE Q AE S E+LS L
Sbjct: 1384 -ELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKK 1442
Query: 507 -HGQLQEARAENSQLTERI----RSIEALLEAGQARDAQDVQASQAEAD--------QQQ 553
HG L E EN L ER + +E L+ + + Q++ A +A+A+ + Q
Sbjct: 1443 AHGLLAE---ENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQ 1499
Query: 554 TRLKELESQVSGLE--------------KEAIELREAVEQQKVKNNDLREKNWKAMEALA 599
+ +ELE + E +E +L VEQ +V + ++ + + LA
Sbjct: 1500 STARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLA 1559
Query: 600 TAEQACK---EKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQ---------- 646
++QA K +KL ++ ES+++ ++AQ E L A L + A+
Sbjct: 1560 DSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNE-LQAQLSQKEQAAEHYKLQMEKAK 1618
Query: 647 -------------QNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQA 693
Q L+ L+++ L K +EAE+T L A
Sbjct: 1619 THYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTA 1678
Query: 694 ECDQYRSILAETEGMLRDLQK 714
+ + +A + LRDL K
Sbjct: 1679 QVRSLEAQVAHADQQLRDLGK 1699
Score = 60.5 bits (145), Expect = 8e-09
Identities = 70/345 (20%), Positives = 153/345 (44%), Gaps = 53/345 (15%)
Query: 238 IEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKE- 296
+E + AG ++ +A ++ + L++++ E+E+ + + A +L L K
Sbjct: 1385 LEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAH 1444
Query: 297 -MAAEKAKAAAGEAKVKKQLV------ARE---QEITAVQARMQASYREHVKEVQQLQGK 346
+ AE+ + A + +Q + ARE QE+ AV+A + E +E Q +
Sbjct: 1445 GLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARE 1504
Query: 347 IRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELV 406
+ + + E ++ +E ++ + T+QVE + + + +Q + ++SK+L
Sbjct: 1505 LEVMTAKYEGAK----VKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQ-VEELSKKLA 1559
Query: 407 EKSEAVRQDEQQRKALEAKAAAFEKQVLQLQA---------------------------S 439
+ +A + +Q+ KA++A+ +++ +LQA +
Sbjct: 1560 DSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKT 1619
Query: 440 HRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSK 499
H ++++ + L E R L Q + LRA+AE+ + QQ + L++ EAE
Sbjct: 1620 HYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQ-----AGLKTKEAE--QT 1672
Query: 500 CEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQA 544
C L+ Q++ A+ + +++R + A A +++ QA
Sbjct: 1673 CRHLT---AQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQA 1714
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 127 bits (320), Expect = 4e-29
Identities = 211/1008 (20%), Positives = 417/1008 (41%), Gaps = 147/1008 (14%)
Query: 47 KEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPD----HDPAPNVTVLLREPVRA 102
K + + Q+ E + KE ++K TK++++K ++ + H LL+E ++A
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQK---TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 103 PAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQV 162
A + A + + E A +++ + ++ A+ + +++ +
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958
Query: 163 LTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAK-KKSGSKKKGPPDADGPLYLPYKTLV 221
L + A Q + K A AK KK + D + L K L
Sbjct: 959 LEEEEA-------------ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1005
Query: 222 STVGSMVFN----EGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLA 277
+ + N E +A+ L ++ ++ +I + + ++ ++ +E EKL
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-------EKSRQELEKLKR 1058
Query: 278 TEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQ---ASYR 334
+ DA+ ++ +L ++A ++K QL +E+E+ A AR+ A
Sbjct: 1059 KLEGDASDFHEQIADLQAQIA-----------ELKMQLAKKEEELQAALARLDDEIAQKN 1107
Query: 335 EHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKL 394
+K++++L+G I LQE L++ R A N+A Q + EL L
Sbjct: 1108 NALKKIRELEGHISDLQEDLDSE---------------RAARNKAEKQ-KRDLGEELEAL 1151
Query: 395 RQELSKVSKELVEKSEAVRQDEQQ----RKALEAKAAAFEKQVLQLQASHRESEEALQKR 450
+ EL + E + EQ+ +KAL+ + + E QV +++ H ++ E L ++
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211
Query: 451 LDEVSRELCHT-------QSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCE-- 501
L++ R + + +A L + + +Q++ KL++ E++SKC
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271
Query: 502 ----------------ELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQAS 545
E+ + G L EA + +L + + S+ + L QD Q
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL--------QDTQEL 1323
Query: 546 QAEADQQQ----TRLKELESQVSGLEKEAIELREA-------VEQQKVKNNDLREKNW-- 592
E +Q+ T+L++LE + + L+ + E EA + ++ +D ++K
Sbjct: 1324 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1383
Query: 593 -KAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLA--QQNY 649
+EAL ++ ++++ +LTQ EE +E +T L L +L V Q+
Sbjct: 1384 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE-KTKNRLQQELDDLVVDLDNQRQL 1442
Query: 650 TEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLR-EAEETQSTLQAECDQYRSILAETEGM 708
L+ + K LL + +D + EA E ++ + L E +
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 709 LRDLQKSVEEEEQVWRAK--VGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTS 766
R + E E + +K VG EL+KS+ + LE +E++K +LE + + T
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK---RALETQMEEMKTQLEELEDELQATE 1559
Query: 767 HLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLS 826
+ LE +M A + + +++ + E + QL E + + ++ R +
Sbjct: 1560 DAKLRLEVNMQALKGQ---FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 827 EMKSHVEDGDIAGAPASSPEAPPAEQDPVQ----LKTQLEWTEAILEDEQTQRQKLTAEF 882
K +E GD+ + A ++ ++ L+ Q++ + LED + R ++ A
Sbjct: 1617 AAKKKLE-GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675
Query: 883 EEAQTSA-------CRLQEEL---EKLRTAGPLESSETEE--ASQLKER--LEKEKKLTS 928
+E + A +LQE+L E+ R LE E E AS L R L+ EK+
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR-- 1733
Query: 929 DLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAEDGSSSKEGTS 976
L +L+E L+ Q + D V+K +Q E+ + +++ T+
Sbjct: 1734 -LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1780
Score = 122 bits (305), Expect = 2e-27
Identities = 204/1018 (20%), Positives = 411/1018 (40%), Gaps = 160/1018 (15%)
Query: 33 MKETSYEEALANQRKEMAK-THHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPN 91
++E EE A Q+ ++ K T K++K + E V K +E+ K+ + +
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER---KLLEERISDL 1011
Query: 92 VTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEP 151
T L E +A + + I V +L K +++ EK K+E
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEV---------RLKKEEKSRQELEKLKRKLEG 1062
Query: 152 AVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADG 211
S I L +A I E + + + Q+ A + A+K + KK
Sbjct: 1063 DASDFHEQIADL--QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK-------- 1112
Query: 212 PLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEE 271
+ L EG L E L + + G+ + LK +LE+
Sbjct: 1113 -----IREL----------EGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157
Query: 272 -------KEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITA 324
+++L A +++ V K L E + A+ + A+ ++L + ++
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1217
Query: 325 VQARMQASYREHVKEVQQLQGKIRTL---QEQLENGPNTQLARLQQENS----------I 371
+A + + + KE L G++R L ++++E+ A++Q+ S
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 372 LRDALNQATSQVES------KQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAK 425
L D +++ ++VES + + KL ++++ +S +L + E ++++ +Q+ + K
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 426 AAAFEKQVLQLQASHRESEEALQ-----------------KRLDEVSRELCHTQSSHASL 468
E++ LQ E EA Q K+L + + + +
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIE 528
+ + E +Q ++ A + KL+ ++ ++ +EL L L R S L ++ R +
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQ---QELDDLVVDLDNQRQLVSNLEKKQRKFD 1454
Query: 529 ALLEAGQARDAQDVQASQA-EADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDL 587
LL + +++ + A E D+ + +E E++ L + E EA E+ + N L
Sbjct: 1455 QLL-----AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 588 REKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQ 647
+ + ME L +++ + +H L ++K E Q ME + L EL Q
Sbjct: 1510 KAE----MEDLVSSKDDVGKNVHELEKSKRALETQ--------MEEMKTQLEELEDELQA 1557
Query: 648 NYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAE--- 704
TE + E LK + DL ++ + EE + LQ + +Y + L +
Sbjct: 1558 --TEDAKLRLEVNMQALK-----GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610
Query: 705 -----------TEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKG 753
EG L+DL+ + + + EE +++ R +++ +L+
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQAD-------SAIKGREEAIKQLRKLQAQMKDFQRELED 1663
Query: 754 ELESSDQV-------REHTSHLEA---ELEKHMAAASAECQNYAKEVAGLRQLLLESQSQ 803
S D++ + LEA +L++ +AAA + E L + L S S
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 804 LDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEW 863
+A + E ++ +A + ++L E + ++E A S A Q QL +L
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNME--------AMSDRVRKATQQAEQLSNELAT 1775
Query: 864 TEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEK--LRTAGPLESSETEEASQLKERLE 921
+ + ++ RQ+L + +E ++ ++ ++ T LE+ + Q+++
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Query: 922 KEKKLTSDLGRAATRLQELL----------KTTQEQLAREKDTVKKLQEQLEKAEDGS 969
+++ T L + +L+E+L + +EQ + VK+L+ QLE+AE+ S
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893
Score = 120 bits (300), Expect = 8e-27
Identities = 174/770 (22%), Positives = 323/770 (41%), Gaps = 97/770 (12%)
Query: 252 WHKATQKGDPVAILKRQLEE---KEKLLATEQEDAAVAKSKLRELN---------KEMAA 299
W + K P+ + RQ EE KE L +E A+++L+EL K +
Sbjct: 834 WWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ 893
Query: 300 EKAKAA----AGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLE 355
E+ +A A +++ +L A++QE+ + M+A E QQLQ + + + +Q+
Sbjct: 894 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM- 952
Query: 356 NGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQEL-------SKVSKELVEK 408
L +E R L E+K + KL E+ +K+SKE
Sbjct: 953 ----LDLEEQLEEEEAARQKLQLEKVTAEAK----IKKLEDEILVMDDQNNKLSKERKLL 1004
Query: 409 SEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASL 468
E + E KA K + +L+ H L+ RL + + + L
Sbjct: 1005 EERISDLTTNLAEEEEKA----KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIE 528
DA E Q+A+L +++ + ++ K EEL +L + A+ + ++IR +E
Sbjct: 1061 EGDASDFHE---QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1117
Query: 529 ALLEAGQARDAQDVQASQAEADQQQTRL-KELESQVSGL-----------------EKEA 570
+ Q D +A++ +A++Q+ L +ELE+ + L E+E
Sbjct: 1118 GHISDLQ-EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV 1176
Query: 571 IELREAVEQQ----KVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLI 626
L++A++++ + + ++R+K+ +A+E L E+L +AK +K +
Sbjct: 1177 TVLKKALDEETRSHEAQVQEMRQKHAQAVEELT-------EQLEQFKRAKANLDKNKQTL 1229
Query: 627 EAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEE 686
E + + L EL VL Q Q+++ K L SD E +
Sbjct: 1230 EKENAD----LAGELRVLGQAK-----QEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 687 TQSTLQAECDQYRSILAETEGMLRDLQKSVEE-EEQVWRAKVGAAEEELQKSRVTVK--H 743
LQ E + +L E EG L K V Q+ + EE QK V+ K
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 744 LEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQ 803
LEE L+ +L+ + +++ + L ++ + + Q++A V L + Q +
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 804 LDAAKSEAQKQS---DELALVRQQL-SEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKT 859
++ + ++++ D+L + +L E+ V D D S+ E + D QL
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD--QLLA 1458
Query: 860 QLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKER 919
+ + + DE R + AE E +T A L LE+ LE+ E E + +
Sbjct: 1459 EEKNISSKYADE---RDRAEAEAREKETKALSLARALEE-----ALEAKEELERTNKMLK 1510
Query: 920 LEKEKKLTS--DLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAED 967
E E ++S D+G+ L++ + + Q+ K +++L+++L+ ED
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1560
Score = 116 bits (290), Expect = 1e-25
Identities = 152/742 (20%), Positives = 325/742 (43%), Gaps = 70/742 (9%)
Query: 266 KRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAE----KAKAAAGE---AKVKKQLVAR 318
K+ LE++ LA E AK ++ K++ A+ ++K + GE A++ ++
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 319 EQEITAVQARMQASYREHVK---EVQQLQGKIRTLQEQLEN------GPNTQLARLQQEN 369
+ E+ +V + + + +K +V L +++ QE L+ +T+L +L++E
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 370 SILRDALNQATSQVESKQNAE--LAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAA 427
+ L+D L++ ++E+KQN E ++ L +LS K+L + + V E+ +K + +
Sbjct: 1346 NSLQDQLDE---EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 428 AFEKQVLQLQASHRESEEA---LQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAE 484
+Q + A++ + E+ LQ+ LD++ +L + L ++ EK Q + Q+
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL----DNQRQLVSNLEKKQRKFDQLLA 1458
Query: 485 LHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQA 544
+ S A+ R + E EAR + ++ R++E LEA + + + +
Sbjct: 1459 EEKNISSKYADERDRAEA---------EAREKETKALSLARALEEALEAKEELERTN-KM 1508
Query: 545 SQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAE-- 602
+AE + + ++ V LEK L +E+ K + +L ++ +A E
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1568
Query: 603 -QACKEKLHSLTQAKEE-SEKQLCLIEAQTMEALLALLPE-----LSVLAQQNYTEWLQD 655
QA K + QA++E +E++ ++ Q E L E L+ A++ L+D
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 656 LKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKS 715
L+ + + +K + L +++++ + +A D+ + E E + L+
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1688
Query: 716 VEE-EEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEA---E 771
+ + +E + A+ + +L+K EE+ E+L L + +++ LEA +
Sbjct: 1689 LMQLQEDLAAAERARKQADLEK--------EELAEELASSLSGRNALQDEKRRLEARIAQ 1740
Query: 772 LEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSH 831
LE+ + + + V Q + ++L +S AQK + +Q E++S
Sbjct: 1741 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1800
Query: 832 VEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACR 891
+ + + GA S ++ A L+ ++ E +E E ++Q T ++
Sbjct: 1801 LHE--MEGAVKSKFKSTIAA-----LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 892 LQEELEKLRTAGPLESSETEEAS----QLKERLEKEKKLTSDLGRAATRLQELLKTTQEQ 947
+ ++E R + E+ + QLK +LE+ ++ + + +LQ L E
Sbjct: 1854 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913
Query: 948 LAREKDTVKKLQEQLEKAEDGS 969
V L+ +L + + S
Sbjct: 1914 NEAMGREVNALKSKLRRGNETS 1935
Score = 103 bits (258), Expect = 6e-22
Identities = 142/670 (21%), Positives = 283/670 (42%), Gaps = 51/670 (7%)
Query: 246 GIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAA 305
G++ + KA + VA L QL++ ++LL E +KLR+L +E + + +
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1353
Query: 306 AGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARL 365
E + K+ L + + + ++ V+ L+ + Q+++EN L +
Sbjct: 1354 E-EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN-----LTQQ 1407
Query: 366 QQENSILRDALNQATSQVESKQN---AELAKLRQELSKVSKE-------LVEKSEAVRQD 415
+E + D L + ++++ + + +L RQ +S + K+ L E+ +
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1467
Query: 416 EQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKA 475
+R EA+A E + L L R EEAL+ + +E+ R ++ L+A+ E
Sbjct: 1468 ADERDRAEAEAREKETKALSLA---RALEEALEAK-EELER-------TNKMLKAEMEDL 1516
Query: 476 QEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQ 535
+ + + +L+ S+ + ++ EE+ QL+E E + +E ++A +
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMK---TQLEELEDELQATEDAKLRLEVNMQALK 1573
Query: 536 ARDAQDVQASQAEADQQQTRL-KELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKA 594
+ +D+QA + ++++ +L ++L + LE E + A +K DL++ +A
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1633
Query: 595 MEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQ 654
A+ E+A K+ L L ++ +++L E A E+ A++N E
Sbjct: 1634 DSAIKGREEAIKQ-LRKLQAQMKDFQREL--------EDARASRDEIFATAKEN--EKKA 1682
Query: 655 DLKEKGPTLLKHPPAPAEPSSDLASKLRE--AEETQSTLQAECDQYRSILAETEGMLRDL 712
E L+ A AE + A +E AEE S+L R+ L + + L
Sbjct: 1683 KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG-----RNALQDEKRRLEAR 1737
Query: 713 QKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAEL 772
+EEE + + + A + ++K+ + L + + + ++ R+ EL
Sbjct: 1738 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1797
Query: 773 EKHM-AAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSH 831
+ A + +A L + + + Q++ E Q + L ++L E+
Sbjct: 1798 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Query: 832 VEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACR 891
VED + A +A QLK QLE E + R+KL E +EA S
Sbjct: 1858 VED-ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1916
Query: 892 LQEELEKLRT 901
+ E+ L++
Sbjct: 1917 MGREVNALKS 1926
Score = 100 bits (248), Expect = 9e-21
Identities = 161/792 (20%), Positives = 332/792 (41%), Gaps = 108/792 (13%)
Query: 130 EKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAP 189
E+L + K +K +E + + ++VL +E K+ EA
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK---------LEAQ 1260
Query: 190 KQEAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQ 249
QE +K G + + + + ++ + S G + EG+A +L + ++ + +Q
Sbjct: 1261 VQELQSKCSDGERARA--ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318
Query: 250 DTWH---KATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRE----LNKEMAAEKA 302
DT + T++ V+ RQLEE+ L + ++ AK L LN +++ K
Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Query: 303 K----AAAGEA--KVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLEN 356
K A+ EA + KK+ + +T A+Y + K +LQ ++ L L+N
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 357 GPN--TQLARLQQE-NSILRDALNQATSQVESKQNAELAKLRQELSKVS--KELVEKSEA 411
+ L + Q++ + +L + N ++ + + AE +E +S + L E EA
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 412 VRQDEQQRKALEAKAAAFE-------KQVLQLQASHRESE---EALQKRLDEVSRELCHT 461
+ E+ K L+A+ K V +L+ S R E E ++ +L+E+ EL T
Sbjct: 1499 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1558
Query: 462 QSSHASLRADA-------------------EKAQEQQQQMAELHSKLQSSE------AEV 496
+ + L + EK ++ Q+Q+ E ++L+ A
Sbjct: 1559 EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1618
Query: 497 RSKCE-ELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAE----ADQ 551
+ K E +L L Q A + +++R ++A ++ Q R+ +D +AS+ E A +
Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ-RELEDARASRDEIFATAKE 1677
Query: 552 QQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHS 611
+ + K LE+ + L+++ A +Q ++ +L E+ ++ + +
Sbjct: 1678 NEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEAR 1737
Query: 612 LTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPA 671
+ Q +EE E+ E MEA+ + + + A+Q E L + T K+ A
Sbjct: 1738 IAQLEEELEE-----EQGNMEAMSDRVRKATQQAEQLSNE----LATERSTAQKNESARQ 1788
Query: 672 E---PSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVG 728
+ + +L SKL E E + +++S +A E + L++ VE+E + +A
Sbjct: 1789 QLERQNKELRSKLHEMEGAVKS------KFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 729 AAEEELQKSRVTVKHLEEI-----------------VEKLKGELESSDQVREHTSHLEAE 771
+ +++ +K + + +E+ V++LK +LE +++ + + +
Sbjct: 1843 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902
Query: 772 LEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSH 831
L++ + A+ + +EV L+ L + + +++ + SE ++
Sbjct: 1903 LQRELDEATESNEAMGREVNALKSKLRRGN---ETSFVPSRRSGGRRVIENADGSEEETD 1959
Query: 832 VEDGDIAGAPAS 843
D D G AS
Sbjct: 1960 TRDADFNGTKAS 1971
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 127 bits (320), Expect = 4e-29
Identities = 211/1008 (20%), Positives = 417/1008 (41%), Gaps = 147/1008 (14%)
Query: 47 KEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPD----HDPAPNVTVLLREPVRA 102
K + + Q+ E + KE ++K TK++++K ++ + H LL+E ++A
Sbjct: 849 KPLLQVTRQEEEMQAKEDELQK---TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 103 PAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQV 162
A + A + + E A +++ + ++ A+ + +++ +
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965
Query: 163 LTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAK-KKSGSKKKGPPDADGPLYLPYKTLV 221
L + A Q + K A AK KK + D + L K L
Sbjct: 966 LEEEEA-------------ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1012
Query: 222 STVGSMVFN----EGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLA 277
+ + N E +A+ L ++ ++ +I + + ++ ++ +E EKL
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-------EKSRQELEKLKR 1065
Query: 278 TEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQ---ASYR 334
+ DA+ ++ +L ++A ++K QL +E+E+ A AR+ A
Sbjct: 1066 KLEGDASDFHEQIADLQAQIA-----------ELKMQLAKKEEELQAALARLDDEIAQKN 1114
Query: 335 EHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKL 394
+K++++L+G I LQE L++ R A N+A Q + EL L
Sbjct: 1115 NALKKIRELEGHISDLQEDLDSE---------------RAARNKAEKQ-KRDLGEELEAL 1158
Query: 395 RQELSKVSKELVEKSEAVRQDEQQ----RKALEAKAAAFEKQVLQLQASHRESEEALQKR 450
+ EL + E + EQ+ +KAL+ + + E QV +++ H ++ E L ++
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218
Query: 451 LDEVSRELCHT-------QSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCE-- 501
L++ R + + +A L + + +Q++ KL++ E++SKC
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278
Query: 502 ----------------ELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQAS 545
E+ + G L EA + +L + + S+ + L QD Q
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL--------QDTQEL 1330
Query: 546 QAEADQQQ----TRLKELESQVSGLEKEAIELREA-------VEQQKVKNNDLREKNW-- 592
E +Q+ T+L++LE + + L+ + E EA + ++ +D ++K
Sbjct: 1331 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1390
Query: 593 -KAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLA--QQNY 649
+EAL ++ ++++ +LTQ EE +E +T L L +L V Q+
Sbjct: 1391 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE-KTKNRLQQELDDLVVDLDNQRQL 1449
Query: 650 TEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLR-EAEETQSTLQAECDQYRSILAETEGM 708
L+ + K LL + +D + EA E ++ + L E +
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 709 LRDLQKSVEEEEQVWRAK--VGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTS 766
R + E E + +K VG EL+KS+ + LE +E++K +LE + + T
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK---RALETQMEEMKTQLEELEDELQATE 1566
Query: 767 HLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLS 826
+ LE +M A + + +++ + E + QL E + + ++ R +
Sbjct: 1567 DAKLRLEVNMQALKGQ---FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 827 EMKSHVEDGDIAGAPASSPEAPPAEQDPVQ----LKTQLEWTEAILEDEQTQRQKLTAEF 882
K +E GD+ + A ++ ++ L+ Q++ + LED + R ++ A
Sbjct: 1624 AAKKKLE-GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682
Query: 883 EEAQTSA-------CRLQEEL---EKLRTAGPLESSETEE--ASQLKER--LEKEKKLTS 928
+E + A +LQE+L E+ R LE E E AS L R L+ EK+
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR-- 1740
Query: 929 DLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAEDGSSSKEGTS 976
L +L+E L+ Q + D V+K +Q E+ + +++ T+
Sbjct: 1741 -LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1787
Score = 122 bits (305), Expect = 2e-27
Identities = 204/1018 (20%), Positives = 411/1018 (40%), Gaps = 160/1018 (15%)
Query: 33 MKETSYEEALANQRKEMAK-THHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPN 91
++E EE A Q+ ++ K T K++K + E V K +E+ K+ + +
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER---KLLEERISDL 1018
Query: 92 VTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEP 151
T L E +A + + I V +L K +++ EK K+E
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEV---------RLKKEEKSRQELEKLKRKLEG 1069
Query: 152 AVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADG 211
S I L +A I E + + + Q+ A + A+K + KK
Sbjct: 1070 DASDFHEQIADL--QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK-------- 1119
Query: 212 PLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEE 271
+ L EG L E L + + G+ + LK +LE+
Sbjct: 1120 -----IREL----------EGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164
Query: 272 -------KEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITA 324
+++L A +++ V K L E + A+ + A+ ++L + ++
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1224
Query: 325 VQARMQASYREHVKEVQQLQGKIRTL---QEQLENGPNTQLARLQQENS----------I 371
+A + + + KE L G++R L ++++E+ A++Q+ S
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 372 LRDALNQATSQVES------KQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAK 425
L D +++ ++VES + + KL ++++ +S +L + E ++++ +Q+ + K
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 426 AAAFEKQVLQLQASHRESEEALQ-----------------KRLDEVSRELCHTQSSHASL 468
E++ LQ E EA Q K+L + + + +
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIE 528
+ + E +Q ++ A + KL+ ++ ++ +EL L L R S L ++ R +
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQ---QELDDLVVDLDNQRQLVSNLEKKQRKFD 1461
Query: 529 ALLEAGQARDAQDVQASQA-EADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDL 587
LL + +++ + A E D+ + +E E++ L + E EA E+ + N L
Sbjct: 1462 QLL-----AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 588 REKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQ 647
+ + ME L +++ + +H L ++K E Q ME + L EL Q
Sbjct: 1517 KAE----MEDLVSSKDDVGKNVHELEKSKRALETQ--------MEEMKTQLEELEDELQA 1564
Query: 648 NYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAE--- 704
TE + E LK + DL ++ + EE + LQ + +Y + L +
Sbjct: 1565 --TEDAKLRLEVNMQALK-----GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617
Query: 705 -----------TEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKG 753
EG L+DL+ + + + EE +++ R +++ +L+
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQAD-------SAIKGREEAIKQLRKLQAQMKDFQRELED 1670
Query: 754 ELESSDQV-------REHTSHLEA---ELEKHMAAASAECQNYAKEVAGLRQLLLESQSQ 803
S D++ + LEA +L++ +AAA + E L + L S S
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 804 LDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEW 863
+A + E ++ +A + ++L E + ++E A S A Q QL +L
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNME--------AMSDRVRKATQQAEQLSNELAT 1782
Query: 864 TEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEK--LRTAGPLESSETEEASQLKERLE 921
+ + ++ RQ+L + +E ++ ++ ++ T LE+ + Q+++
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Query: 922 KEKKLTSDLGRAATRLQELL----------KTTQEQLAREKDTVKKLQEQLEKAEDGS 969
+++ T L + +L+E+L + +EQ + VK+L+ QLE+AE+ S
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900
Score = 120 bits (300), Expect = 8e-27
Identities = 174/770 (22%), Positives = 323/770 (41%), Gaps = 97/770 (12%)
Query: 252 WHKATQKGDPVAILKRQLEE---KEKLLATEQEDAAVAKSKLRELN---------KEMAA 299
W + K P+ + RQ EE KE L +E A+++L+EL K +
Sbjct: 841 WWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ 900
Query: 300 EKAKAA----AGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLE 355
E+ +A A +++ +L A++QE+ + M+A E QQLQ + + + +Q+
Sbjct: 901 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM- 959
Query: 356 NGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQEL-------SKVSKELVEK 408
L +E R L E+K + KL E+ +K+SKE
Sbjct: 960 ----LDLEEQLEEEEAARQKLQLEKVTAEAK----IKKLEDEILVMDDQNNKLSKERKLL 1011
Query: 409 SEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASL 468
E + E KA K + +L+ H L+ RL + + + L
Sbjct: 1012 EERISDLTTNLAEEEEKA----KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIE 528
DA E Q+A+L +++ + ++ K EEL +L + A+ + ++IR +E
Sbjct: 1068 EGDASDFHE---QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1124
Query: 529 ALLEAGQARDAQDVQASQAEADQQQTRL-KELESQVSGL-----------------EKEA 570
+ Q D +A++ +A++Q+ L +ELE+ + L E+E
Sbjct: 1125 GHISDLQ-EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV 1183
Query: 571 IELREAVEQQ----KVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLI 626
L++A++++ + + ++R+K+ +A+E L E+L +AK +K +
Sbjct: 1184 TVLKKALDEETRSHEAQVQEMRQKHAQAVEELT-------EQLEQFKRAKANLDKNKQTL 1236
Query: 627 EAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEE 686
E + + L EL VL Q Q+++ K L SD E +
Sbjct: 1237 EKENAD----LAGELRVLGQAK-----QEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 687 TQSTLQAECDQYRSILAETEGMLRDLQKSVEE-EEQVWRAKVGAAEEELQKSRVTVK--H 743
LQ E + +L E EG L K V Q+ + EE QK V+ K
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 744 LEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQ 803
LEE L+ +L+ + +++ + L ++ + + Q++A V L + Q +
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 804 LDAAKSEAQKQS---DELALVRQQL-SEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKT 859
++ + ++++ D+L + +L E+ V D D S+ E + D QL
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD--QLLA 1465
Query: 860 QLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKER 919
+ + + DE R + AE E +T A L LE+ LE+ E E + +
Sbjct: 1466 EEKNISSKYADE---RDRAEAEAREKETKALSLARALEE-----ALEAKEELERTNKMLK 1517
Query: 920 LEKEKKLTS--DLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAED 967
E E ++S D+G+ L++ + + Q+ K +++L+++L+ ED
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1567
Score = 116 bits (290), Expect = 1e-25
Identities = 152/742 (20%), Positives = 325/742 (43%), Gaps = 70/742 (9%)
Query: 266 KRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAE----KAKAAAGE---AKVKKQLVAR 318
K+ LE++ LA E AK ++ K++ A+ ++K + GE A++ ++
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 319 EQEITAVQARMQASYREHVK---EVQQLQGKIRTLQEQLEN------GPNTQLARLQQEN 369
+ E+ +V + + + +K +V L +++ QE L+ +T+L +L++E
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 370 SILRDALNQATSQVESKQNAE--LAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAA 427
+ L+D L++ ++E+KQN E ++ L +LS K+L + + V E+ +K + +
Sbjct: 1353 NSLQDQLDE---EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 428 AFEKQVLQLQASHRESEEA---LQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAE 484
+Q + A++ + E+ LQ+ LD++ +L + L ++ EK Q + Q+
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL----DNQRQLVSNLEKKQRKFDQLLA 1465
Query: 485 LHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQA 544
+ S A+ R + E EAR + ++ R++E LEA + + + +
Sbjct: 1466 EEKNISSKYADERDRAEA---------EAREKETKALSLARALEEALEAKEELERTN-KM 1515
Query: 545 SQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAE-- 602
+AE + + ++ V LEK L +E+ K + +L ++ +A E
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1575
Query: 603 -QACKEKLHSLTQAKEE-SEKQLCLIEAQTMEALLALLPE-----LSVLAQQNYTEWLQD 655
QA K + QA++E +E++ ++ Q E L E L+ A++ L+D
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 656 LKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKS 715
L+ + + +K + L +++++ + +A D+ + E E + L+
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1695
Query: 716 VEE-EEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEA---E 771
+ + +E + A+ + +L+K EE+ E+L L + +++ LEA +
Sbjct: 1696 LMQLQEDLAAAERARKQADLEK--------EELAEELASSLSGRNALQDEKRRLEARIAQ 1747
Query: 772 LEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSH 831
LE+ + + + V Q + ++L +S AQK + +Q E++S
Sbjct: 1748 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1807
Query: 832 VEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACR 891
+ + + GA S ++ A L+ ++ E +E E ++Q T ++
Sbjct: 1808 LHE--MEGAVKSKFKSTIAA-----LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 892 LQEELEKLRTAGPLESSETEEAS----QLKERLEKEKKLTSDLGRAATRLQELLKTTQEQ 947
+ ++E R + E+ + QLK +LE+ ++ + + +LQ L E
Sbjct: 1861 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
Query: 948 LAREKDTVKKLQEQLEKAEDGS 969
V L+ +L + + S
Sbjct: 1921 NEAMGREVNALKSKLRRGNETS 1942
Score = 103 bits (258), Expect = 6e-22
Identities = 142/670 (21%), Positives = 283/670 (42%), Gaps = 51/670 (7%)
Query: 246 GIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAA 305
G++ + KA + VA L QL++ ++LL E +KLR+L +E + + +
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1360
Query: 306 AGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARL 365
E + K+ L + + + ++ V+ L+ + Q+++EN L +
Sbjct: 1361 E-EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN-----LTQQ 1414
Query: 366 QQENSILRDALNQATSQVESKQN---AELAKLRQELSKVSKE-------LVEKSEAVRQD 415
+E + D L + ++++ + + +L RQ +S + K+ L E+ +
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1474
Query: 416 EQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKA 475
+R EA+A E + L L R EEAL+ + +E+ R ++ L+A+ E
Sbjct: 1475 ADERDRAEAEAREKETKALSLA---RALEEALEAK-EELER-------TNKMLKAEMEDL 1523
Query: 476 QEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQ 535
+ + + +L+ S+ + ++ EE+ QL+E E + +E ++A +
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMK---TQLEELEDELQATEDAKLRLEVNMQALK 1580
Query: 536 ARDAQDVQASQAEADQQQTRL-KELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKA 594
+ +D+QA + ++++ +L ++L + LE E + A +K DL++ +A
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1640
Query: 595 MEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQ 654
A+ E+A K+ L L ++ +++L E A E+ A++N E
Sbjct: 1641 DSAIKGREEAIKQ-LRKLQAQMKDFQREL--------EDARASRDEIFATAKEN--EKKA 1689
Query: 655 DLKEKGPTLLKHPPAPAEPSSDLASKLRE--AEETQSTLQAECDQYRSILAETEGMLRDL 712
E L+ A AE + A +E AEE S+L R+ L + + L
Sbjct: 1690 KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG-----RNALQDEKRRLEAR 1744
Query: 713 QKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAEL 772
+EEE + + + A + ++K+ + L + + + ++ R+ EL
Sbjct: 1745 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1804
Query: 773 EKHM-AAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSH 831
+ A + +A L + + + Q++ E Q + L ++L E+
Sbjct: 1805 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Query: 832 VEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACR 891
VED + A +A QLK QLE E + R+KL E +EA S
Sbjct: 1865 VED-ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1923
Query: 892 LQEELEKLRT 901
+ E+ L++
Sbjct: 1924 MGREVNALKS 1933
Score = 100 bits (248), Expect = 9e-21
Identities = 161/792 (20%), Positives = 332/792 (41%), Gaps = 108/792 (13%)
Query: 130 EKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAP 189
E+L + K +K +E + + ++VL +E K+ EA
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK---------LEAQ 1267
Query: 190 KQEAPAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQ 249
QE +K G + + + + ++ + S G + EG+A +L + ++ + +Q
Sbjct: 1268 VQELQSKCSDGERARA--ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325
Query: 250 DTWH---KATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRE----LNKEMAAEKA 302
DT + T++ V+ RQLEE+ L + ++ AK L LN +++ K
Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Query: 303 K----AAAGEA--KVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLEN 356
K A+ EA + KK+ + +T A+Y + K +LQ ++ L L+N
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 357 GPN--TQLARLQQE-NSILRDALNQATSQVESKQNAELAKLRQELSKVS--KELVEKSEA 411
+ L + Q++ + +L + N ++ + + AE +E +S + L E EA
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1505
Query: 412 VRQDEQQRKALEAKAAAFE-------KQVLQLQASHRESE---EALQKRLDEVSRELCHT 461
+ E+ K L+A+ K V +L+ S R E E ++ +L+E+ EL T
Sbjct: 1506 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1565
Query: 462 QSSHASLRADA-------------------EKAQEQQQQMAELHSKLQSSE------AEV 496
+ + L + EK ++ Q+Q+ E ++L+ A
Sbjct: 1566 EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1625
Query: 497 RSKCE-ELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAE----ADQ 551
+ K E +L L Q A + +++R ++A ++ Q R+ +D +AS+ E A +
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ-RELEDARASRDEIFATAKE 1684
Query: 552 QQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHS 611
+ + K LE+ + L+++ A +Q ++ +L E+ ++ + +
Sbjct: 1685 NEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEAR 1744
Query: 612 LTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPA 671
+ Q +EE E+ E MEA+ + + + A+Q E L + T K+ A
Sbjct: 1745 IAQLEEELEE-----EQGNMEAMSDRVRKATQQAEQLSNE----LATERSTAQKNESARQ 1795
Query: 672 E---PSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVG 728
+ + +L SKL E E + +++S +A E + L++ VE+E + +A
Sbjct: 1796 QLERQNKELRSKLHEMEGAVKS------KFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 729 AAEEELQKSRVTVKHLEEI-----------------VEKLKGELESSDQVREHTSHLEAE 771
+ +++ +K + + +E+ V++LK +LE +++ + + +
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909
Query: 772 LEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSH 831
L++ + A+ + +EV L+ L + + +++ + SE ++
Sbjct: 1910 LQRELDEATESNEAMGREVNALKSKLRRGN---ETSFVPSRRSGGRRVIENADGSEEETD 1966
Query: 832 VEDGDIAGAPAS 843
D D G AS
Sbjct: 1967 TRDADFNGTKAS 1978
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 127 bits (320), Expect = 4e-29
Identities = 211/1008 (20%), Positives = 417/1008 (41%), Gaps = 147/1008 (14%)
Query: 47 KEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPD----HDPAPNVTVLLREPVRA 102
K + + Q+ E + KE ++K TK++++K ++ + H LL+E ++A
Sbjct: 849 KPLLQVTRQEEEMQAKEDELQK---TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 103 PAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQV 162
A + A + + E A +++ + ++ A+ + +++ +
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965
Query: 163 LTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAK-KKSGSKKKGPPDADGPLYLPYKTLV 221
L + A Q + K A AK KK + D + L K L
Sbjct: 966 LEEEEA-------------ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1012
Query: 222 STVGSMVFN----EGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLA 277
+ + N E +A+ L ++ ++ +I + + ++ ++ +E EKL
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-------EKSRQELEKLKR 1065
Query: 278 TEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQ---ASYR 334
+ DA+ ++ +L ++A ++K QL +E+E+ A AR+ A
Sbjct: 1066 KLEGDASDFHEQIADLQAQIA-----------ELKMQLAKKEEELQAALARLDDEIAQKN 1114
Query: 335 EHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKL 394
+K++++L+G I LQE L++ R A N+A Q + EL L
Sbjct: 1115 NALKKIRELEGHISDLQEDLDSE---------------RAARNKAEKQ-KRDLGEELEAL 1158
Query: 395 RQELSKVSKELVEKSEAVRQDEQQ----RKALEAKAAAFEKQVLQLQASHRESEEALQKR 450
+ EL + E + EQ+ +KAL+ + + E QV +++ H ++ E L ++
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218
Query: 451 LDEVSRELCHT-------QSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCE-- 501
L++ R + + +A L + + +Q++ KL++ E++SKC
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278
Query: 502 ----------------ELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQAS 545
E+ + G L EA + +L + + S+ + L QD Q
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL--------QDTQEL 1330
Query: 546 QAEADQQQ----TRLKELESQVSGLEKEAIELREA-------VEQQKVKNNDLREKNW-- 592
E +Q+ T+L++LE + + L+ + E EA + ++ +D ++K
Sbjct: 1331 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1390
Query: 593 -KAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLA--QQNY 649
+EAL ++ ++++ +LTQ EE +E +T L L +L V Q+
Sbjct: 1391 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE-KTKNRLQQELDDLVVDLDNQRQL 1449
Query: 650 TEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLR-EAEETQSTLQAECDQYRSILAETEGM 708
L+ + K LL + +D + EA E ++ + L E +
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 709 LRDLQKSVEEEEQVWRAK--VGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTS 766
R + E E + +K VG EL+KS+ + LE +E++K +LE + + T
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK---RALETQMEEMKTQLEELEDELQATE 1566
Query: 767 HLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLS 826
+ LE +M A + + +++ + E + QL E + + ++ R +
Sbjct: 1567 DAKLRLEVNMQALKGQ---FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 827 EMKSHVEDGDIAGAPASSPEAPPAEQDPVQ----LKTQLEWTEAILEDEQTQRQKLTAEF 882
K +E GD+ + A ++ ++ L+ Q++ + LED + R ++ A
Sbjct: 1624 AAKKKLE-GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682
Query: 883 EEAQTSA-------CRLQEEL---EKLRTAGPLESSETEE--ASQLKER--LEKEKKLTS 928
+E + A +LQE+L E+ R LE E E AS L R L+ EK+
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR-- 1740
Query: 929 DLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAEDGSSSKEGTS 976
L +L+E L+ Q + D V+K +Q E+ + +++ T+
Sbjct: 1741 -LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1787
Score = 122 bits (305), Expect = 2e-27
Identities = 204/1018 (20%), Positives = 411/1018 (40%), Gaps = 160/1018 (15%)
Query: 33 MKETSYEEALANQRKEMAK-THHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPN 91
++E EE A Q+ ++ K T K++K + E V K +E+ K+ + +
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER---KLLEERISDL 1018
Query: 92 VTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEP 151
T L E +A + + I V +L K +++ EK K+E
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEV---------RLKKEEKSRQELEKLKRKLEG 1069
Query: 152 AVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADG 211
S I L +A I E + + + Q+ A + A+K + KK
Sbjct: 1070 DASDFHEQIADL--QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK-------- 1119
Query: 212 PLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEE 271
+ L EG L E L + + G+ + LK +LE+
Sbjct: 1120 -----IREL----------EGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164
Query: 272 -------KEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITA 324
+++L A +++ V K L E + A+ + A+ ++L + ++
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1224
Query: 325 VQARMQASYREHVKEVQQLQGKIRTL---QEQLENGPNTQLARLQQENS----------I 371
+A + + + KE L G++R L ++++E+ A++Q+ S
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 372 LRDALNQATSQVES------KQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAK 425
L D +++ ++VES + + KL ++++ +S +L + E ++++ +Q+ + K
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 426 AAAFEKQVLQLQASHRESEEALQ-----------------KRLDEVSRELCHTQSSHASL 468
E++ LQ E EA Q K+L + + + +
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIE 528
+ + E +Q ++ A + KL+ ++ ++ +EL L L R S L ++ R +
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQ---QELDDLVVDLDNQRQLVSNLEKKQRKFD 1461
Query: 529 ALLEAGQARDAQDVQASQA-EADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDL 587
LL + +++ + A E D+ + +E E++ L + E EA E+ + N L
Sbjct: 1462 QLL-----AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 588 REKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQ 647
+ + ME L +++ + +H L ++K E Q ME + L EL Q
Sbjct: 1517 KAE----MEDLVSSKDDVGKNVHELEKSKRALETQ--------MEEMKTQLEELEDELQA 1564
Query: 648 NYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAE--- 704
TE + E LK + DL ++ + EE + LQ + +Y + L +
Sbjct: 1565 --TEDAKLRLEVNMQALK-----GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617
Query: 705 -----------TEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKG 753
EG L+DL+ + + + EE +++ R +++ +L+
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQAD-------SAIKGREEAIKQLRKLQAQMKDFQRELED 1670
Query: 754 ELESSDQV-------REHTSHLEA---ELEKHMAAASAECQNYAKEVAGLRQLLLESQSQ 803
S D++ + LEA +L++ +AAA + E L + L S S
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 804 LDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEW 863
+A + E ++ +A + ++L E + ++E A S A Q QL +L
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNME--------AMSDRVRKATQQAEQLSNELAT 1782
Query: 864 TEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEK--LRTAGPLESSETEEASQLKERLE 921
+ + ++ RQ+L + +E ++ ++ ++ T LE+ + Q+++
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Query: 922 KEKKLTSDLGRAATRLQELL----------KTTQEQLAREKDTVKKLQEQLEKAEDGS 969
+++ T L + +L+E+L + +EQ + VK+L+ QLE+AE+ S
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900
Score = 120 bits (300), Expect = 8e-27
Identities = 174/770 (22%), Positives = 323/770 (41%), Gaps = 97/770 (12%)
Query: 252 WHKATQKGDPVAILKRQLEE---KEKLLATEQEDAAVAKSKLRELN---------KEMAA 299
W + K P+ + RQ EE KE L +E A+++L+EL K +
Sbjct: 841 WWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ 900
Query: 300 EKAKAA----AGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLE 355
E+ +A A +++ +L A++QE+ + M+A E QQLQ + + + +Q+
Sbjct: 901 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM- 959
Query: 356 NGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQEL-------SKVSKELVEK 408
L +E R L E+K + KL E+ +K+SKE
Sbjct: 960 ----LDLEEQLEEEEAARQKLQLEKVTAEAK----IKKLEDEILVMDDQNNKLSKERKLL 1011
Query: 409 SEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASL 468
E + E KA K + +L+ H L+ RL + + + L
Sbjct: 1012 EERISDLTTNLAEEEEKA----KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIE 528
DA E Q+A+L +++ + ++ K EEL +L + A+ + ++IR +E
Sbjct: 1068 EGDASDFHE---QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1124
Query: 529 ALLEAGQARDAQDVQASQAEADQQQTRL-KELESQVSGL-----------------EKEA 570
+ Q D +A++ +A++Q+ L +ELE+ + L E+E
Sbjct: 1125 GHISDLQ-EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV 1183
Query: 571 IELREAVEQQ----KVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLI 626
L++A++++ + + ++R+K+ +A+E L E+L +AK +K +
Sbjct: 1184 TVLKKALDEETRSHEAQVQEMRQKHAQAVEELT-------EQLEQFKRAKANLDKNKQTL 1236
Query: 627 EAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEE 686
E + + L EL VL Q Q+++ K L SD E +
Sbjct: 1237 EKENAD----LAGELRVLGQAK-----QEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 687 TQSTLQAECDQYRSILAETEGMLRDLQKSVEE-EEQVWRAKVGAAEEELQKSRVTVK--H 743
LQ E + +L E EG L K V Q+ + EE QK V+ K
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 744 LEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQ 803
LEE L+ +L+ + +++ + L ++ + + Q++A V L + Q +
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 804 LDAAKSEAQKQS---DELALVRQQL-SEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKT 859
++ + ++++ D+L + +L E+ V D D S+ E + D QL
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD--QLLA 1465
Query: 860 QLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKER 919
+ + + DE R + AE E +T A L LE+ LE+ E E + +
Sbjct: 1466 EEKNISSKYADE---RDRAEAEAREKETKALSLARALEE-----ALEAKEELERTNKMLK 1517
Query: 920 LEKEKKLTS--DLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAED 967
E E ++S D+G+ L++ + + Q+ K +++L+++L+ ED
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1567
Score = 109 bits (273), Expect = 1e-23
Identities = 144/704 (20%), Positives = 316/704 (44%), Gaps = 55/704 (7%)
Query: 266 KRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAE----KAKAAAGE---AKVKKQLVAR 318
K+ LE++ LA E AK ++ K++ A+ ++K + GE A++ ++
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 319 EQEITAVQARMQASYREHVK---EVQQLQGKIRTLQEQLEN------GPNTQLARLQQEN 369
+ E+ +V + + + +K +V L +++ QE L+ +T+L +L++E
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 370 SILRDALNQATSQVESKQNAE--LAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAA 427
+ L+D L++ ++E+KQN E ++ L +LS K+L + + V E+ +K + +
Sbjct: 1353 NSLQDQLDE---EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 428 AFEKQVLQLQASHRESEEA---LQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAE 484
+Q + A++ + E+ LQ+ LD++ +L + + ++L K + +
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 485 LHSKLQS----SEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEA------G 534
+ SK +EAE R K + L L+EA +L + ++A +E
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1529
Query: 535 QARDAQDVQAS----QAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREK 590
++ +++ S + + ++ +T+L+ELE ++ E +LR V Q +K R+
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA--KLRLEVNMQALKGQFERDL 1587
Query: 591 NWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEAL-----LALLPELSVLA 645
+ E + + +LH E+ KQ L A + L L + ++
Sbjct: 1588 QARD-EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646
Query: 646 QQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAET 705
++ + L+ L+ + + ++ + +E E+ +L+A+ Q + LA
Sbjct: 1647 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706
Query: 706 EGMLR--DLQKSVEEEEQVWRAKVG--AAEEELQKSRVTVKHLEEIVEKLKGELES-SDQ 760
E + DL+K E E++ + G A ++E ++ + LEE +E+ +G +E+ SD+
Sbjct: 1707 ERARKQADLEKE-ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1765
Query: 761 VREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQ-KQSDELA 819
VR+ T E +L +A + Q L + E +S+L + + K +A
Sbjct: 1766 VRKATQQAE-QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824
Query: 820 LVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLT 879
+ ++++++ VE + A++ ++ ++ Q+E + E + Q +K
Sbjct: 1825 ALEAKIAQLEEQVEQ-EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1883
Query: 880 AEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKE 923
A ++ + +EE +++ E +EA++ E + +E
Sbjct: 1884 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1927
Score = 105 bits (263), Expect = 2e-22
Identities = 147/682 (21%), Positives = 288/682 (42%), Gaps = 55/682 (8%)
Query: 246 GIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAA 305
G++ + KA + VA L QL++ ++LL E +KLR+L +E + + +
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1360
Query: 306 AGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARL 365
E + K+ L + + + ++ V+ L+ + Q+++EN L +
Sbjct: 1361 E-EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN-----LTQQ 1414
Query: 366 QQENSILRDALNQATSQVESKQN---AELAKLRQELSKVSKE-------LVEKSEAVRQD 415
+E + D L + ++++ + + +L RQ +S + K+ L E+ +
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1474
Query: 416 EQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKA 475
+R EA+A E + L L R EEAL+ + +E+ R ++ L+A+ E
Sbjct: 1475 ADERDRAEAEAREKETKALSLA---RALEEALEAK-EELER-------TNKMLKAEMEDL 1523
Query: 476 QEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQ 535
+ + + +L+ S+ + ++ EE+ QL+E E + +E ++A +
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMK---TQLEELEDELQATEDAKLRLEVNMQALK 1580
Query: 536 ARDAQDVQASQAEADQQQTRL-KELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKA 594
+ +D+QA + ++++ +L ++L + LE E + A +K DL++ +A
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1640
Query: 595 MEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQ 654
A+ E+A K+ L L ++ +++L E A E+ A++N E
Sbjct: 1641 DSAIKGREEAIKQ-LRKLQAQMKDFQREL--------EDARASRDEIFATAKEN--EKKA 1689
Query: 655 DLKEKGPTLLKHPPAPAEPSSDLASKLRE--AEETQSTLQAECDQYRSILAETEGMLRDL 712
E L+ A AE + A +E AEE S+L R+ L + + L
Sbjct: 1690 KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG-----RNALQDEKRRLEAR 1744
Query: 713 QKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAEL 772
+EEE + + + A + ++K+ + L + + + ++ R+ EL
Sbjct: 1745 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1804
Query: 773 EKHM-AAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSH 831
+ A + +A L + + + Q++ E Q + L ++L E+
Sbjct: 1805 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Query: 832 VEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACR 891
VED + A +A QLK QLE E + R+KL E +EA S
Sbjct: 1865 VED-ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1923
Query: 892 LQEEL----EKLRTAGPLESSE 909
+ E+ KLR P E+S+
Sbjct: 1924 MGREVNALKSKLRGPPPQETSQ 1945
Score = 90.1 bits (222), Expect = 9e-18
Identities = 178/826 (21%), Positives = 335/826 (40%), Gaps = 116/826 (14%)
Query: 34 KETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVT 93
+ET EA Q +EM + H Q VE+ ++ K+ K + K + + D A +
Sbjct: 1192 EETRSHEA---QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1248
Query: 94 VLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAV 153
VL A + + A V + Q K + + + + KV K++ V
Sbjct: 1249 VL--------GQAKQEVEHKKKKLEAQVQEL----QSKCSDGERARAELNDKVHKLQNEV 1296
Query: 154 SSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKK---------- 203
SV + KA ++ A + Q + QE +K + S K
Sbjct: 1297 ESVTGMLNEAEGKA--IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1354
Query: 204 -KGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQR----LIEILSEKAGIIQDTWHKATQK 258
+ D + + +ST+ + + + + +E L E Q TQ+
Sbjct: 1355 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1414
Query: 259 GDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAR 318
+ A +LE+ + L E +D V R+L + ++ K QL+A
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF--------DQLLAE 1466
Query: 319 EQEITAVQA----RMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRD 374
E+ I++ A R +A RE KE + L R L+E LE L++ N +L+
Sbjct: 1467 EKNISSKYADERDRAEAEARE--KETKAL-SLARALEEALE-----AKEELERTNKMLKA 1518
Query: 375 ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVR-QDEQQRKALEAKAAAFEKQV 433
+ S + ++ K EL K + L + E ++ Q E+ L+A A +
Sbjct: 1519 EMEDLVSSKD-----DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573
Query: 434 LQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSE 493
+ +QA + E LQ R ++ + EK ++ Q+Q+ E ++L+
Sbjct: 1574 VNMQALKGQFERDLQARDEQ-----------------NEEKRRQLQRQLHEYETELEDER 1616
Query: 494 ------AEVRSKCE-ELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQ 546
A + K E +L L Q A + +++R ++A ++ Q R+ +D +AS+
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ-RELEDARASR 1675
Query: 547 ----AEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAE 602
A A + + + K LE+ + L+++ A +Q ++ +L E+ ++ +
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1735
Query: 603 QACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPT 662
+ + Q +EE E+ E MEA+ + + + A+Q E L + T
Sbjct: 1736 DEKRRLEARIAQLEEELEE-----EQGNMEAMSDRVRKATQQAEQLSNE----LATERST 1786
Query: 663 LLKHPPAPAE---PSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEE 719
K+ A + + +L SKL E E A +++S +A E + L++ VE+E
Sbjct: 1787 AQKNESARQQLERQNKELRSKLHEME------GAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Query: 720 EQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAA 779
R K A + QK K L+EI+ +++ E + ++Q +E A + K +
Sbjct: 1841 A---REKQAATKSLKQKD----KKLKEILLQVEDERKMAEQYKEQAEKGNARV-KQLKRQ 1892
Query: 780 SAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQL 825
E + ++ + R+ L Q +LD A + E+ ++ +L
Sbjct: 1893 LEEAEEESQRINANRRKL---QRELDEATESNEAMGREVNALKSKL 1935
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 127 bits (320), Expect = 4e-29
Identities = 211/1008 (20%), Positives = 417/1008 (41%), Gaps = 147/1008 (14%)
Query: 47 KEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPD----HDPAPNVTVLLREPVRA 102
K + + Q+ E + KE ++K TK++++K ++ + H LL+E ++A
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQK---TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 103 PAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQV 162
A + A + + E A +++ + ++ A+ + +++ +
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958
Query: 163 LTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAK-KKSGSKKKGPPDADGPLYLPYKTLV 221
L + A Q + K A AK KK + D + L K L
Sbjct: 959 LEEEEA-------------ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1005
Query: 222 STVGSMVFN----EGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLA 277
+ + N E +A+ L ++ ++ +I + + ++ ++ +E EKL
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-------EKSRQELEKLKR 1058
Query: 278 TEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQ---ASYR 334
+ DA+ ++ +L ++A ++K QL +E+E+ A AR+ A
Sbjct: 1059 KLEGDASDFHEQIADLQAQIA-----------ELKMQLAKKEEELQAALARLDDEIAQKN 1107
Query: 335 EHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKL 394
+K++++L+G I LQE L++ R A N+A Q + EL L
Sbjct: 1108 NALKKIRELEGHISDLQEDLDSE---------------RAARNKAEKQ-KRDLGEELEAL 1151
Query: 395 RQELSKVSKELVEKSEAVRQDEQQ----RKALEAKAAAFEKQVLQLQASHRESEEALQKR 450
+ EL + E + EQ+ +KAL+ + + E QV +++ H ++ E L ++
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211
Query: 451 LDEVSRELCHT-------QSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCE-- 501
L++ R + + +A L + + +Q++ KL++ E++SKC
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271
Query: 502 ----------------ELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQAS 545
E+ + G L EA + +L + + S+ + L QD Q
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL--------QDTQEL 1323
Query: 546 QAEADQQQ----TRLKELESQVSGLEKEAIELREA-------VEQQKVKNNDLREKNW-- 592
E +Q+ T+L++LE + + L+ + E EA + ++ +D ++K
Sbjct: 1324 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1383
Query: 593 -KAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLA--QQNY 649
+EAL ++ ++++ +LTQ EE +E +T L L +L V Q+
Sbjct: 1384 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE-KTKNRLQQELDDLVVDLDNQRQL 1442
Query: 650 TEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLR-EAEETQSTLQAECDQYRSILAETEGM 708
L+ + K LL + +D + EA E ++ + L E +
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 709 LRDLQKSVEEEEQVWRAK--VGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTS 766
R + E E + +K VG EL+KS+ + LE +E++K +LE + + T
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK---RALETQMEEMKTQLEELEDELQATE 1559
Query: 767 HLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLS 826
+ LE +M A + + +++ + E + QL E + + ++ R +
Sbjct: 1560 DAKLRLEVNMQALKGQ---FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 827 EMKSHVEDGDIAGAPASSPEAPPAEQDPVQ----LKTQLEWTEAILEDEQTQRQKLTAEF 882
K +E GD+ + A ++ ++ L+ Q++ + LED + R ++ A
Sbjct: 1617 AAKKKLE-GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675
Query: 883 EEAQTSA-------CRLQEEL---EKLRTAGPLESSETEE--ASQLKER--LEKEKKLTS 928
+E + A +LQE+L E+ R LE E E AS L R L+ EK+
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR-- 1733
Query: 929 DLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAEDGSSSKEGTS 976
L +L+E L+ Q + D V+K +Q E+ + +++ T+
Sbjct: 1734 -LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1780
Score = 122 bits (305), Expect = 2e-27
Identities = 204/1018 (20%), Positives = 411/1018 (40%), Gaps = 160/1018 (15%)
Query: 33 MKETSYEEALANQRKEMAK-THHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPN 91
++E EE A Q+ ++ K T K++K + E V K +E+ K+ + +
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER---KLLEERISDL 1011
Query: 92 VTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEP 151
T L E +A + + I V +L K +++ EK K+E
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEV---------RLKKEEKSRQELEKLKRKLEG 1062
Query: 152 AVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPPDADG 211
S I L +A I E + + + Q+ A + A+K + KK
Sbjct: 1063 DASDFHEQIADL--QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK-------- 1112
Query: 212 PLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEE 271
+ L EG L E L + + G+ + LK +LE+
Sbjct: 1113 -----IREL----------EGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157
Query: 272 -------KEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITA 324
+++L A +++ V K L E + A+ + A+ ++L + ++
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1217
Query: 325 VQARMQASYREHVKEVQQLQGKIRTL---QEQLENGPNTQLARLQQENS----------I 371
+A + + + KE L G++R L ++++E+ A++Q+ S
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 372 LRDALNQATSQVES------KQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAK 425
L D +++ ++VES + + KL ++++ +S +L + E ++++ +Q+ + K
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 426 AAAFEKQVLQLQASHRESEEALQ-----------------KRLDEVSRELCHTQSSHASL 468
E++ LQ E EA Q K+L + + + +
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIE 528
+ + E +Q ++ A + KL+ ++ ++ +EL L L R S L ++ R +
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQ---QELDDLVVDLDNQRQLVSNLEKKQRKFD 1454
Query: 529 ALLEAGQARDAQDVQASQA-EADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDL 587
LL + +++ + A E D+ + +E E++ L + E EA E+ + N L
Sbjct: 1455 QLL-----AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 588 REKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQ 647
+ + ME L +++ + +H L ++K E Q ME + L EL Q
Sbjct: 1510 KAE----MEDLVSSKDDVGKNVHELEKSKRALETQ--------MEEMKTQLEELEDELQA 1557
Query: 648 NYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAE--- 704
TE + E LK + DL ++ + EE + LQ + +Y + L +
Sbjct: 1558 --TEDAKLRLEVNMQALK-----GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610
Query: 705 -----------TEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKG 753
EG L+DL+ + + + EE +++ R +++ +L+
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQAD-------SAIKGREEAIKQLRKLQAQMKDFQRELED 1663
Query: 754 ELESSDQV-------REHTSHLEA---ELEKHMAAASAECQNYAKEVAGLRQLLLESQSQ 803
S D++ + LEA +L++ +AAA + E L + L S S
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 804 LDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEW 863
+A + E ++ +A + ++L E + ++E A S A Q QL +L
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNME--------AMSDRVRKATQQAEQLSNELAT 1775
Query: 864 TEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEK--LRTAGPLESSETEEASQLKERLE 921
+ + ++ RQ+L + +E ++ ++ ++ T LE+ + Q+++
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Query: 922 KEKKLTSDLGRAATRLQELL----------KTTQEQLAREKDTVKKLQEQLEKAEDGS 969
+++ T L + +L+E+L + +EQ + VK+L+ QLE+AE+ S
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893
Score = 120 bits (300), Expect = 8e-27
Identities = 174/770 (22%), Positives = 323/770 (41%), Gaps = 97/770 (12%)
Query: 252 WHKATQKGDPVAILKRQLEE---KEKLLATEQEDAAVAKSKLRELN---------KEMAA 299
W + K P+ + RQ EE KE L +E A+++L+EL K +
Sbjct: 834 WWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ 893
Query: 300 EKAKAA----AGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLE 355
E+ +A A +++ +L A++QE+ + M+A E QQLQ + + + +Q+
Sbjct: 894 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM- 952
Query: 356 NGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQEL-------SKVSKELVEK 408
L +E R L E+K + KL E+ +K+SKE
Sbjct: 953 ----LDLEEQLEEEEAARQKLQLEKVTAEAK----IKKLEDEILVMDDQNNKLSKERKLL 1004
Query: 409 SEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASL 468
E + E KA K + +L+ H L+ RL + + + L
Sbjct: 1005 EERISDLTTNLAEEEEKA----KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060
Query: 469 RADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIE 528
DA E Q+A+L +++ + ++ K EEL +L + A+ + ++IR +E
Sbjct: 1061 EGDASDFHE---QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1117
Query: 529 ALLEAGQARDAQDVQASQAEADQQQTRL-KELESQVSGL-----------------EKEA 570
+ Q D +A++ +A++Q+ L +ELE+ + L E+E
Sbjct: 1118 GHISDLQ-EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV 1176
Query: 571 IELREAVEQQ----KVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLI 626
L++A++++ + + ++R+K+ +A+E L E+L +AK +K +
Sbjct: 1177 TVLKKALDEETRSHEAQVQEMRQKHAQAVEELT-------EQLEQFKRAKANLDKNKQTL 1229
Query: 627 EAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEE 686
E + + L EL VL Q Q+++ K L SD E +
Sbjct: 1230 EKENAD----LAGELRVLGQAK-----QEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 687 TQSTLQAECDQYRSILAETEGMLRDLQKSVEE-EEQVWRAKVGAAEEELQKSRVTVK--H 743
LQ E + +L E EG L K V Q+ + EE QK V+ K
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 744 LEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQ 803
LEE L+ +L+ + +++ + L ++ + + Q++A V L + Q +
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 804 LDAAKSEAQKQS---DELALVRQQL-SEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKT 859
++ + ++++ D+L + +L E+ V D D S+ E + D QL
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD--QLLA 1458
Query: 860 QLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKER 919
+ + + DE R + AE E +T A L LE+ LE+ E E + +
Sbjct: 1459 EEKNISSKYADE---RDRAEAEAREKETKALSLARALEE-----ALEAKEELERTNKMLK 1510
Query: 920 LEKEKKLTS--DLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAED 967
E E ++S D+G+ L++ + + Q+ K +++L+++L+ ED
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1560
Score = 109 bits (273), Expect = 1e-23
Identities = 144/704 (20%), Positives = 316/704 (44%), Gaps = 55/704 (7%)
Query: 266 KRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAE----KAKAAAGE---AKVKKQLVAR 318
K+ LE++ LA E AK ++ K++ A+ ++K + GE A++ ++
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 319 EQEITAVQARMQASYREHVK---EVQQLQGKIRTLQEQLEN------GPNTQLARLQQEN 369
+ E+ +V + + + +K +V L +++ QE L+ +T+L +L++E
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 370 SILRDALNQATSQVESKQNAE--LAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAA 427
+ L+D L++ ++E+KQN E ++ L +LS K+L + + V E+ +K + +
Sbjct: 1346 NSLQDQLDE---EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 428 AFEKQVLQLQASHRESEEA---LQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAE 484
+Q + A++ + E+ LQ+ LD++ +L + + ++L K + +
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 485 LHSKLQS----SEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEA------G 534
+ SK +EAE R K + L L+EA +L + ++A +E
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522
Query: 535 QARDAQDVQAS----QAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREK 590
++ +++ S + + ++ +T+L+ELE ++ E +LR V Q +K R+
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA--KLRLEVNMQALKGQFERDL 1580
Query: 591 NWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEAL-----LALLPELSVLA 645
+ E + + +LH E+ KQ L A + L L + ++
Sbjct: 1581 QARD-EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639
Query: 646 QQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAET 705
++ + L+ L+ + + ++ + +E E+ +L+A+ Q + LA
Sbjct: 1640 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699
Query: 706 EGMLR--DLQKSVEEEEQVWRAKVG--AAEEELQKSRVTVKHLEEIVEKLKGELES-SDQ 760
E + DL+K E E++ + G A ++E ++ + LEE +E+ +G +E+ SD+
Sbjct: 1700 ERARKQADLEKE-ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1758
Query: 761 VREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQ-KQSDELA 819
VR+ T E +L +A + Q L + E +S+L + + K +A
Sbjct: 1759 VRKATQQAE-QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1817
Query: 820 LVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLT 879
+ ++++++ VE + A++ ++ ++ Q+E + E + Q +K
Sbjct: 1818 ALEAKIAQLEEQVEQ-EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1876
Query: 880 AEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKE 923
A ++ + +EE +++ E +EA++ E + +E
Sbjct: 1877 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1920
Score = 105 bits (263), Expect = 2e-22
Identities = 147/682 (21%), Positives = 288/682 (42%), Gaps = 55/682 (8%)
Query: 246 GIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAA 305
G++ + KA + VA L QL++ ++LL E +KLR+L +E + + +
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1353
Query: 306 AGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARL 365
E + K+ L + + + ++ V+ L+ + Q+++EN L +
Sbjct: 1354 E-EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN-----LTQQ 1407
Query: 366 QQENSILRDALNQATSQVESKQN---AELAKLRQELSKVSKE-------LVEKSEAVRQD 415
+E + D L + ++++ + + +L RQ +S + K+ L E+ +
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1467
Query: 416 EQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKA 475
+R EA+A E + L L R EEAL+ + +E+ R ++ L+A+ E
Sbjct: 1468 ADERDRAEAEAREKETKALSLA---RALEEALEAK-EELER-------TNKMLKAEMEDL 1516
Query: 476 QEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQ 535
+ + + +L+ S+ + ++ EE+ QL+E E + +E ++A +
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMK---TQLEELEDELQATEDAKLRLEVNMQALK 1573
Query: 536 ARDAQDVQASQAEADQQQTRL-KELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKA 594
+ +D+QA + ++++ +L ++L + LE E + A +K DL++ +A
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1633
Query: 595 MEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQ 654
A+ E+A K+ L L ++ +++L E A E+ A++N E
Sbjct: 1634 DSAIKGREEAIKQ-LRKLQAQMKDFQREL--------EDARASRDEIFATAKEN--EKKA 1682
Query: 655 DLKEKGPTLLKHPPAPAEPSSDLASKLRE--AEETQSTLQAECDQYRSILAETEGMLRDL 712
E L+ A AE + A +E AEE S+L R+ L + + L
Sbjct: 1683 KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG-----RNALQDEKRRLEAR 1737
Query: 713 QKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAEL 772
+EEE + + + A + ++K+ + L + + + ++ R+ EL
Sbjct: 1738 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1797
Query: 773 EKHM-AAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSH 831
+ A + +A L + + + Q++ E Q + L ++L E+
Sbjct: 1798 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Query: 832 VEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACR 891
VED + A +A QLK QLE E + R+KL E +EA S
Sbjct: 1858 VED-ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1916
Query: 892 LQEEL----EKLRTAGPLESSE 909
+ E+ KLR P E+S+
Sbjct: 1917 MGREVNALKSKLRGPPPQETSQ 1938
Score = 90.1 bits (222), Expect = 9e-18
Identities = 178/826 (21%), Positives = 335/826 (40%), Gaps = 116/826 (14%)
Query: 34 KETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVT 93
+ET EA Q +EM + H Q VE+ ++ K+ K + K + + D A +
Sbjct: 1185 EETRSHEA---QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1241
Query: 94 VLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAV 153
VL A + + A V + Q K + + + + KV K++ V
Sbjct: 1242 VL--------GQAKQEVEHKKKKLEAQVQEL----QSKCSDGERARAELNDKVHKLQNEV 1289
Query: 154 SSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKK---------- 203
SV + KA ++ A + Q + QE +K + S K
Sbjct: 1290 ESVTGMLNEAEGKA--IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1347
Query: 204 -KGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQR----LIEILSEKAGIIQDTWHKATQK 258
+ D + + +ST+ + + + + +E L E Q TQ+
Sbjct: 1348 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1407
Query: 259 GDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAR 318
+ A +LE+ + L E +D V R+L + ++ K QL+A
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF--------DQLLAE 1459
Query: 319 EQEITAVQA----RMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRD 374
E+ I++ A R +A RE KE + L R L+E LE L++ N +L+
Sbjct: 1460 EKNISSKYADERDRAEAEARE--KETKAL-SLARALEEALE-----AKEELERTNKMLKA 1511
Query: 375 ALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVR-QDEQQRKALEAKAAAFEKQV 433
+ S + ++ K EL K + L + E ++ Q E+ L+A A +
Sbjct: 1512 EMEDLVSSKD-----DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566
Query: 434 LQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSE 493
+ +QA + E LQ R ++ + EK ++ Q+Q+ E ++L+
Sbjct: 1567 VNMQALKGQFERDLQARDEQ-----------------NEEKRRQLQRQLHEYETELEDER 1609
Query: 494 ------AEVRSKCE-ELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQ 546
A + K E +L L Q A + +++R ++A ++ Q R+ +D +AS+
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ-RELEDARASR 1668
Query: 547 ----AEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAE 602
A A + + + K LE+ + L+++ A +Q ++ +L E+ ++ +
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1728
Query: 603 QACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPT 662
+ + Q +EE E+ E MEA+ + + + A+Q E L + T
Sbjct: 1729 DEKRRLEARIAQLEEELEE-----EQGNMEAMSDRVRKATQQAEQLSNE----LATERST 1779
Query: 663 LLKHPPAPAE---PSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEE 719
K+ A + + +L SKL E E A +++S +A E + L++ VE+E
Sbjct: 1780 AQKNESARQQLERQNKELRSKLHEME------GAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Query: 720 EQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAA 779
R K A + QK K L+EI+ +++ E + ++Q +E A + K +
Sbjct: 1834 A---REKQAATKSLKQKD----KKLKEILLQVEDERKMAEQYKEQAEKGNARV-KQLKRQ 1885
Query: 780 SAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQL 825
E + ++ + R+ L Q +LD A + E+ ++ +L
Sbjct: 1886 LEEAEEESQRINANRRKL---QRELDEATESNEAMGREVNALKSKL 1928
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.304 0.120 0.308
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,217,028
Number of Sequences: 37866
Number of extensions: 1675844
Number of successful extensions: 30771
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 575
Number of HSP's successfully gapped in prelim test: 1528
Number of HSP's that attempted gapping in prelim test: 10562
Number of HSP's gapped (non-prelim): 10703
length of query: 977
length of database: 18,247,518
effective HSP length: 112
effective length of query: 865
effective length of database: 14,006,526
effective search space: 12115644990
effective search space used: 12115644990
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.