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Search of human proteins with 166235140
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166235140 seizure related 6 homolog (mouse)-like 2 isoform 4
[Homo sapiens]
(809 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166235140 seizure related 6 homolog (mouse)-like 2 isoform 4 ... 1702 0.0
gi|6912612 seizure related 6 homolog (mouse)-like 2 isoform 1 [H... 1353 0.0
gi|166235138 seizure related 6 homolog (mouse)-like 2 isoform 3 ... 1319 0.0
gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2 ... 1319 0.0
gi|148839346 seizure related 6 homolog isoform 2 [Homo sapiens] 690 0.0
gi|32261332 seizure related 6 homolog (mouse)-like precursor [Ho... 679 0.0
gi|148839280 seizure related 6 homolog isoform 1 [Homo sapiens] 674 0.0
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 196 9e-50
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 194 2e-49
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 194 2e-49
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 193 6e-49
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 192 1e-48
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 102 1e-21
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi... 102 1e-21
gi|148886654 polydom [Homo sapiens] 99 2e-20
gi|168693643 decay accelerating factor for complement isoform 2 ... 97 6e-20
gi|10835143 decay accelerating factor for complement isoform 1 p... 97 6e-20
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ... 92 3e-18
gi|157419154 selectin P precursor [Homo sapiens] 89 1e-17
gi|27502417 CD46 antigen, complement regulatory protein isoform ... 82 2e-15
gi|27502419 CD46 antigen, complement regulatory protein isoform ... 82 3e-15
gi|27502427 CD46 antigen, complement regulatory protein isoform ... 82 3e-15
gi|27502415 CD46 antigen, complement regulatory protein isoform ... 81 3e-15
gi|27502421 CD46 antigen, complement regulatory protein isoform ... 80 8e-15
gi|27502413 CD46 antigen, complement regulatory protein isoform ... 80 8e-15
gi|27502411 CD46 antigen, complement regulatory protein isoform ... 80 8e-15
gi|27502409 CD46 antigen, complement regulatory protein isoform ... 80 8e-15
gi|27502407 CD46 antigen, complement regulatory protein isoform ... 80 8e-15
gi|27502405 CD46 antigen, complement regulatory protein isoform ... 80 8e-15
gi|27502402 CD46 antigen, complement regulatory protein isoform ... 80 8e-15
>gi|166235140 seizure related 6 homolog (mouse)-like 2 isoform 4
[Homo sapiens]
Length = 809
Score = 1702 bits (4408), Expect = 0.0
Identities = 809/809 (100%), Positives = 809/809 (100%)
Query: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 60
MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
Sbjct: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 60
Query: 61 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP 120
RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP
Sbjct: 61 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP 120
Query: 121 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPP 180
ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPP
Sbjct: 121 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPP 180
Query: 181 RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIH 240
RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIH
Sbjct: 181 RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIH 240
Query: 241 NATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLS 300
NATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLS
Sbjct: 241 NATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLS 300
Query: 301 PVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV 360
PVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV
Sbjct: 301 PVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV 360
Query: 361 TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEP 420
TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEP
Sbjct: 361 TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEP 420
Query: 421 AGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLA 480
AGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLA
Sbjct: 421 AGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLA 480
Query: 481 QLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGW 540
QLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGW
Sbjct: 481 QLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGW 540
Query: 541 RTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANG 600
RTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANG
Sbjct: 541 RTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANG 600
Query: 601 HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNP 660
HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNP
Sbjct: 601 HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNP 660
Query: 661 GVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEE 720
GVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEE
Sbjct: 661 GVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEE 720
Query: 721 LLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGS 780
LLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGS
Sbjct: 721 LLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGS 780
Query: 781 HSYSPITVESDFSNPLYEAGDTREYEVSI 809
HSYSPITVESDFSNPLYEAGDTREYEVSI
Sbjct: 781 HSYSPITVESDFSNPLYEAGDTREYEVSI 809
>gi|6912612 seizure related 6 homolog (mouse)-like 2 isoform 1 [Homo
sapiens]
Length = 853
Score = 1353 bits (3502), Expect = 0.0
Identities = 639/639 (100%), Positives = 639/639 (100%)
Query: 171 AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS 230
AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS
Sbjct: 215 AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS 274
Query: 231 CMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290
CMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL
Sbjct: 275 CMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 334
Query: 291 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC 350
MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC
Sbjct: 335 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC 394
Query: 351 FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 410
FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK
Sbjct: 395 FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 454
Query: 411 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFD 470
AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFD
Sbjct: 455 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFD 514
Query: 471 GDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC 530
GDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC
Sbjct: 515 GDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC 574
Query: 531 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMT 590
PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMT
Sbjct: 575 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMT 634
Query: 591 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 650
CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC
Sbjct: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 694
Query: 651 ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ 710
ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ
Sbjct: 695 ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ 754
Query: 711 PPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQ 770
PPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQ
Sbjct: 755 PPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQ 814
Query: 771 GKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI 809
GKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI
Sbjct: 815 GKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI 853
Score = 156 bits (394), Expect = 8e-38
Identities = 216/859 (25%), Positives = 313/859 (36%), Gaps = 255/859 (29%)
Query: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 60
MGTPRAQHPPPPQLLFLILLSCPWIQGL P E L E
Sbjct: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGL---------------PLKEEEILPE------- 38
Query: 61 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP 120
PGS+ PT+A+ + L L R E G
Sbjct: 39 ---------PGSET-PTVASEALAELLHGALLRRGPEMGY-------------------- 68
Query: 121 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPP 180
PGPPLGPEGGEEETTTT + TT T
Sbjct: 69 ------------------LPGPPLGPEGGEEETTTT------IITTTT------------ 92
Query: 181 RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIH 240
V+ T P ++C N GE G +
Sbjct: 93 ------VTTTVTSP-------------------VLCNNNIS---EGE---------GYVE 115
Query: 241 NATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP-L 299
+ LG VS G L C + I G + + + ++L ++ + L++ GGSP L
Sbjct: 116 SPDLGSPVSRTLG-----LLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGL 170
Query: 300 SPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLL-------------SLRFEAFE 346
+P L++++ L + +P N LLL + ++A+
Sbjct: 171 AP-------------RLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYL 217
Query: 347 EDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 406
F P AHG+V+ TD PG ATF C GY L+ + C++ T P WN
Sbjct: 218 LSCGFPPRPAHGDVSVTD--LHPGGTATFHCDSGYQLQ---GEETLICLNGTRPSWNGET 272
Query: 407 PACKAMCGGEL-SEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-GD 464
P+C A CGG + + G ++SP+ + P C W + E +R+ L E +++ E D
Sbjct: 273 PSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDND 332
Query: 465 MLTLFDGDGPSARVLAQL-RGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKE 523
L + G P + V+ P R L+S L ++ + P NP L L F E
Sbjct: 333 RLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSET-PANPLL---LSLRF-E 387
Query: 524 VPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL---GSDILTC--QWDLSW 578
D C P G T + + G + T+ C PGY L + + C + W
Sbjct: 388 AFEEDRC-FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHW 446
Query: 579 SAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPG---------------Y 623
+ PAC+ + C GE++ +P C+ G
Sbjct: 447 NDTEPACKAM--CG--GELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEIL 502
Query: 624 SLEGAAMLTCYSRDTGTPKWSDRV-------------PKCALKYE-------PCLNPG-- 661
++ MLT + D + + ++ P L+++ P L G
Sbjct: 503 NVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFV 562
Query: 662 -----VPEN-----------GYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS 705
VP N G++T G L + C G+EL+G +TC
Sbjct: 563 LHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC--QWDL 620
Query: 706 QWTSQPPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIY 765
W++ PP C+ ++ DP G A P+ G ++
Sbjct: 621 SWSAAPPACQ------------KIMTCADPGEIANGHRTASDAGFPV--------GSHVQ 660
Query: 766 YTKLQGKSLFGFSGSHSYS 784
Y L G SL G + YS
Sbjct: 661 YRCLPGYSLEGAAMLTCYS 679
>gi|166235138 seizure related 6 homolog (mouse)-like 2 isoform 3
[Homo sapiens]
Length = 840
Score = 1319 bits (3414), Expect = 0.0
Identities = 626/639 (97%), Positives = 626/639 (97%), Gaps = 13/639 (2%)
Query: 171 AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS 230
AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS
Sbjct: 215 AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS 274
Query: 231 CMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290
CMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL
Sbjct: 275 CMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 334
Query: 291 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC 350
MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC
Sbjct: 335 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC 394
Query: 351 FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 410
FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK
Sbjct: 395 FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 454
Query: 411 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFD 470
AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFD
Sbjct: 455 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFD 514
Query: 471 GDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC 530
GDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC
Sbjct: 515 GDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC 574
Query: 531 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMT 590
PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMT
Sbjct: 575 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMT 634
Query: 591 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 650
CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC
Sbjct: 635 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 694
Query: 651 ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ 710
ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ
Sbjct: 695 ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ 754
Query: 711 PPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQ 770
PPLCK VTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQ
Sbjct: 755 PPLCK-------------VTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQ 801
Query: 771 GKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI 809
GKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI
Sbjct: 802 GKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI 840
Score = 156 bits (394), Expect = 8e-38
Identities = 216/859 (25%), Positives = 313/859 (36%), Gaps = 255/859 (29%)
Query: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 60
MGTPRAQHPPPPQLLFLILLSCPWIQGL P E L E
Sbjct: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGL---------------PLKEEEILPE------- 38
Query: 61 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP 120
PGS+ PT+A+ + L L R E G
Sbjct: 39 ---------PGSET-PTVASEALAELLHGALLRRGPEMGY-------------------- 68
Query: 121 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPP 180
PGPPLGPEGGEEETTTT + TT T
Sbjct: 69 ------------------LPGPPLGPEGGEEETTTT------IITTTT------------ 92
Query: 181 RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIH 240
V+ T P ++C N GE G +
Sbjct: 93 ------VTTTVTSP-------------------VLCNNNIS---EGE---------GYVE 115
Query: 241 NATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP-L 299
+ LG VS G L C + I G + + + ++L ++ + L++ GGSP L
Sbjct: 116 SPDLGSPVSRTLG-----LLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGL 170
Query: 300 SPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLL-------------SLRFEAFE 346
+P L++++ L + +P N LLL + ++A+
Sbjct: 171 AP-------------RLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYL 217
Query: 347 EDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 406
F P AHG+V+ TD PG ATF C GY L+ + C++ T P WN
Sbjct: 218 LSCGFPPRPAHGDVSVTD--LHPGGTATFHCDSGYQLQ---GEETLICLNGTRPSWNGET 272
Query: 407 PACKAMCGGEL-SEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-GD 464
P+C A CGG + + G ++SP+ + P C W + E +R+ L E +++ E D
Sbjct: 273 PSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDND 332
Query: 465 MLTLFDGDGPSARVLAQL-RGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKE 523
L + G P + V+ P R L+S L ++ + P NP L L F E
Sbjct: 333 RLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSET-PANPLL---LSLRF-E 387
Query: 524 VPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL---GSDILTC--QWDLSW 578
D C P G T + + G + T+ C PGY L + + C + W
Sbjct: 388 AFEEDRC-FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHW 446
Query: 579 SAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPG---------------Y 623
+ PAC+ + C GE++ +P C+ G
Sbjct: 447 NDTEPACKAM--CG--GELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEIL 502
Query: 624 SLEGAAMLTCYSRDTGTPKWSDRV-------------PKCALKYE-------PCLNPG-- 661
++ MLT + D + + ++ P L+++ P L G
Sbjct: 503 NVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFV 562
Query: 662 -----VPEN-----------GYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS 705
VP N G++T G L + C G+EL+G +TC
Sbjct: 563 LHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC--QWDL 620
Query: 706 QWTSQPPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIY 765
W++ PP C+ ++ DP G A P+ G ++
Sbjct: 621 SWSAAPPACQ------------KIMTCADPGEIANGHRTASDAGFPV--------GSHVQ 660
Query: 766 YTKLQGKSLFGFSGSHSYS 784
Y L G SL G + YS
Sbjct: 661 YRCLPGYSLEGAAMLTCYS 679
>gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2
[Homo sapiens]
Length = 910
Score = 1319 bits (3414), Expect = 0.0
Identities = 626/639 (97%), Positives = 626/639 (97%), Gaps = 13/639 (2%)
Query: 171 AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS 230
AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS
Sbjct: 285 AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS 344
Query: 231 CMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290
CMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL
Sbjct: 345 CMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 404
Query: 291 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC 350
MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC
Sbjct: 405 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC 464
Query: 351 FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 410
FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK
Sbjct: 465 FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 524
Query: 411 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFD 470
AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFD
Sbjct: 525 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFD 584
Query: 471 GDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC 530
GDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC
Sbjct: 585 GDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC 644
Query: 531 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMT 590
PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMT
Sbjct: 645 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMT 704
Query: 591 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 650
CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC
Sbjct: 705 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 764
Query: 651 ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ 710
ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ
Sbjct: 765 ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ 824
Query: 711 PPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQ 770
PPLCK VTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQ
Sbjct: 825 PPLCK-------------VTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQ 871
Query: 771 GKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI 809
GKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI
Sbjct: 872 GKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI 910
Score = 427 bits (1097), Expect = e-119
Identities = 320/859 (37%), Positives = 411/859 (47%), Gaps = 185/859 (21%)
Query: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 60
MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
Sbjct: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 60
Query: 61 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP 120
RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP
Sbjct: 61 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP 120
Query: 121 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPP 180
ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSP
Sbjct: 121 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSP---------- 170
Query: 181 RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIH 240
++C N GE G +
Sbjct: 171 ---------------------------------VLCNNNIS---EGE---------GYVE 185
Query: 241 NATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP-L 299
+ LG VS G L C + I G + + + ++L ++ + L++ GGSP L
Sbjct: 186 SPDLGSPVSRTLG-----LLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGL 240
Query: 300 SPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLL-------------SLRFEAFE 346
+P L++++ L + +P N LLL + ++A+
Sbjct: 241 AP-------------RLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYL 287
Query: 347 EDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 406
F P AHG+V+ TD PG ATF C GY L+ + C++ T P WN
Sbjct: 288 LSCGFPPRPAHGDVSVTD--LHPGGTATFHCDSGYQLQ---GEETLICLNGTRPSWNGET 342
Query: 407 PACKAMCGGEL-SEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-GD 464
P+C A CGG + + G ++SP+ + P C W + E +R+ L E +++ E D
Sbjct: 343 PSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDND 402
Query: 465 MLTLFDGDGPSARVLAQL-RGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKE 523
L + G P + V+ P R L+S L ++ + P NP L L F E
Sbjct: 403 RLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSET-PANPLL---LSLRF-E 457
Query: 524 VPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL---GSDILTC--QWDLSW 578
D C P G T + + G + T+ C PGY L + + C + W
Sbjct: 458 AFEEDRC-FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHW 516
Query: 579 SAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPG---------------Y 623
+ PAC+ + C GE++ +P C+ G
Sbjct: 517 NDTEPACKAM--CG--GELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEIL 572
Query: 624 SLEGAAMLTCYSRDTGTPKWSDRV-------------PKCALKYE-------PCLNPG-- 661
++ MLT + D + + ++ P L+++ P L G
Sbjct: 573 NVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFV 632
Query: 662 -----VPEN-----------GYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS 705
VP N G++T G L + C G+EL+G +TC
Sbjct: 633 LHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC--QWDL 690
Query: 706 QWTSQPPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIY 765
W++ PP C+ ++ DP G A P+ G ++
Sbjct: 691 SWSAAPPACQ------------KIMTCADPGEIANGHRTASDAGFPV--------GSHVQ 730
Query: 766 YTKLQGKSLFGFSGSHSYS 784
Y L G SL G + YS
Sbjct: 731 YRCLPGYSLEGAAMLTCYS 749
>gi|148839346 seizure related 6 homolog isoform 2 [Homo sapiens]
Length = 993
Score = 690 bits (1780), Expect = 0.0
Identities = 323/644 (50%), Positives = 445/644 (69%), Gaps = 7/644 (1%)
Query: 171 AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS 230
AYLLSC FP RPA+GDV+VT LHPGG+A FHC +GYQL+G L CLN T+P W+ + P
Sbjct: 352 AYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPV 411
Query: 231 CMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290
C+A+CGG I NAT GRIVSP G NLTC W++EA EG+RLHLHFE+VSL ED+DRL
Sbjct: 412 CIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRL 471
Query: 291 MVRSGGSPLSPVIYDS-DMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 349
++R+G + +P +YDS +++ +P GL+S + +VEL +++ ++LR+EAF++
Sbjct: 472 IIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGH 531
Query: 350 CFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPAC 409
C+ PF+ +GN +++ P Y G FSC PGY LE IECVDP +P WN+TEPAC
Sbjct: 532 CYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSI--IIECVDPHDPQWNETEPAC 589
Query: 410 KAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLF 469
+A+C GE+++ AGVVLSP+WP+ Y GQDC+WGVHV+E+KRI+L + +L + GD+LT +
Sbjct: 590 RAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFY 649
Query: 470 DGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT 529
DGD +ARVL Q GP+ +L +S D+T+QFQ+ PG G QGFV+HF EVPRNDT
Sbjct: 650 DGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDT 709
Query: 530 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM 589
CPELP GW++ S +L+ GTV+TYQC PGY+++GS +L CQWDL+WS P+CQ++
Sbjct: 710 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVT 769
Query: 590 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 649
+C DPG++ + R S FPVG+ VQY C G+ L G+++LTC+ R G+PKWSDR PK
Sbjct: 770 SCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPK 829
Query: 650 CAL-KYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 708
C L + +PC PENG ++ K + AG ++ F C G+ L G+ +I CVPGHPS W+
Sbjct: 830 CLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWS 889
Query: 709 SQPPLCKVA-YEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYT 767
PP+C+ A + ++R L+V + S L+ ++A AI LPL +++L GVY Y++
Sbjct: 890 DPPPICRAASLDGFYNSRSLDVAKAPAASSTLDAAHIAAAIFLPLVAMVLLVGGVYFYFS 949
Query: 768 KLQGKSLFGF--SGSHSYSPITVESDFSNPLYEAGDTREYEVSI 809
+LQGKS Y+ IT+ES F NP YE G+TREYEVSI
Sbjct: 950 RLQGKSSLQLPRPRPRPYNRITIESAFDNPTYETGETREYEVSI 993
Score = 124 bits (311), Expect = 3e-28
Identities = 166/619 (26%), Positives = 244/619 (39%), Gaps = 72/619 (11%)
Query: 37 PEPGSETPTVASEALAELLHGALLRRGPEMGYLPGSDR-DPTLATPPAGQTLAVPS-LPR 94
PE G T A L L H LL + G G + P L P PS LPR
Sbjct: 51 PERGVHFVTTAP-TLKLLNHHPLLEEFLQEGLEKGDEELRPALPFQPDPPAPFTPSPLPR 109
Query: 95 ATEPGTGPLTTAVTP-------NGVRGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPE 147
+ P+ T+ TP GP +PE +P TAP PP P+ P LGP
Sbjct: 110 LANQDSRPVFTSPTPAMAAVPTQPQSKEGPWSPESESPMLRITAPLPPGPSMAVPTLGP- 168
Query: 148 GGEEETTTTIITTTTVTTTVTSPAYLLSCGFPPRPAHGDVSVTDLHPG--GTATFHCDSG 205
GE +TT + T T P G RP +V G GT T SG
Sbjct: 169 -GEIASTTP--PSRAWTPTQEGP------GDMGRPWVAEVVSQGAGIGIQGTITSSTASG 219
Query: 206 YQLQGEETLICLNGTRP--------SWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVG 257
+ T + T SWN P G++ + T + SP G
Sbjct: 220 DDEETTTTTTIITTTITTVQTPGPCSWNFSGPE------GSLDSPT--DLSSPTDVG--- 268
Query: 258 PNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLI 317
L C + I G + + + +SL E + GG P+ S + RG +
Sbjct: 269 --LDCFFYISVYPGYGVEIKVQNISLREGETVTVEGLGGPDPLPLANQSFL----LRGQV 322
Query: 318 SDAQSLYVELLSET---PANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALAT 374
+ + L ++ PA P ++A+ F A+G+VT T PG A
Sbjct: 323 IRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVT--SLHPGGSAR 380
Query: 375 FSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGEL-SEPAGVVLSPDWPQSY 433
F C GY L+ + C++ T+P W+ EP C A CGG + + G ++SP +P +Y
Sbjct: 381 FHCATGYQLK---GARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNY 437
Query: 434 SPGQDCVWGVHVQEEKRILLQVEILNVRE-GDMLTLFDGDGPSARVLAQLRGPQ--PRRR 490
S C W + E +R+ L E +++ E D L + +GD A + + P
Sbjct: 438 SNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEG 497
Query: 491 LLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIR 550
LLSSG ++ + G G L + E + C E P ++G ++S
Sbjct: 498 LLSSGKHFFVELST----DSSGAAAGMALRY-EAFQQGHCYE-PFVKYGNFSSSTPTYPV 551
Query: 551 GTVLTYQCEPGYEL-LGSDILTC--QWDLSWSAAPPACQKIMTCADPGEIANGHRTASDA 607
GT + + C+PGY L GS I+ C D W+ PAC+ + + GEI +
Sbjct: 552 GTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCS----GEITDSAGVVLSP 607
Query: 608 GFPVGSHVQYRCLPGYSLE 626
+P C+ G +E
Sbjct: 608 NWPEPYGRGQDCIWGVHVE 626
>gi|32261332 seizure related 6 homolog (mouse)-like precursor [Homo
sapiens]
Length = 1024
Score = 679 bits (1751), Expect = 0.0
Identities = 323/643 (50%), Positives = 432/643 (67%), Gaps = 10/643 (1%)
Query: 171 AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS 230
A++LSC FP RP GDV+V DLH GG A FHC GY+LQG + L C+N ++P W+ + P
Sbjct: 388 AFMLSCNFPRRPDSGDVTVMDLHSGGVAHFHCHLGYELQGAKMLTCINASKPHWSSQEPI 447
Query: 231 CMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290
C A CGG +HNAT+GR++SP + C W IEA EG++LHLHFER+ L D DR+
Sbjct: 448 CSAPCGGAVHNATIGRVLSPSYPENTNGSQFCIWTIEAPEGQKLHLHFERLLL-HDKDRM 506
Query: 291 MVRSGGSPLSPVIYDS-DMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 349
V SG + S ++YDS + VP GL+S+ ++ +E S+ ++RFEAFE+
Sbjct: 507 TVHSGQTNKSALLYDSLQTESVPFEGLLSEGNTIRIEFTSDQARAASTFNIRFEAFEKGH 566
Query: 350 CFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPAC 409
C+ P++ +GN TT+DP Y G + F+C PG++LE P IEC++ +P+WNDTEP C
Sbjct: 567 CYEPYIQNGNFTTSDPTYNIGTIVEFTCDPGHSLEQG--PAIIECINVRDPYWNDTEPLC 624
Query: 410 KAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLF 469
+AMCGGELS AGVVLSP+WP+ Y G+DC+W +HV EEKRI L ++ LN+ D+LT++
Sbjct: 625 RAMCGGELSAVAGVVLSPNWPEPYVEGEDCIWKIHVGEEKRIFLDIQFLNLSNSDILTIY 684
Query: 470 DGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT 529
DGD +L Q G ++L SS PDLT+QF + P G GQGF++++ EV RND+
Sbjct: 685 DGDEVMPHILGQYLGNSGPQKLYSSTPDLTIQFHSDPAGLIFGKGQGFIMNYIEVSRNDS 744
Query: 530 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM 589
C +LP + GW+T SH +L+RG +TYQC+PGY+++GSD LTCQWDLSWS+ PP C+KIM
Sbjct: 745 CSDLPEIQNGWKTTSHTELVRGARITYQCDPGYDIVGSDTLTCQWDLSWSSDPPFCEKIM 804
Query: 590 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 649
C DPGE+ + R SD VG+ +QY C PG+ LEG+++LTCYSR+TGTP W+ R+P
Sbjct: 805 YCTDPGEVDHSTRLISDPVLLVGTTIQYTCNPGFVLEGSSLLTCYSRETGTPIWTSRLPH 864
Query: 650 CALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 708
C + C NPG+PENGYQ LYK Y GESL F CYEGFEL+GEVTI C+ G PS W
Sbjct: 865 CVSEESLACDNPGLPENGYQILYKRLYLPGESLTFMCYEGFELMGEVTIRCILGQPSHWN 924
Query: 709 SQPPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTK 768
P+CKV + LEV + LEGGN+ALAI +P+ ++ +L G YIY T+
Sbjct: 925 GPLPVCKVNQDSF--EHALEVAEAA-AETSLEGGNMALAIFIPVLIISLLLGGAYIYITR 981
Query: 769 LQGKS--LFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI 809
+ S SH YS ITVE++F NP+YE G+TREYEVSI
Sbjct: 982 CRYYSNLRLPLMYSHPYSQITVETEFDNPIYETGETREYEVSI 1024
Score = 58.5 bits (140), Expect = 2e-08
Identities = 53/184 (28%), Positives = 84/184 (45%), Gaps = 11/184 (5%)
Query: 405 TEPACKAMCGGELSEPAGVVLSPDWPQ-SYSPGQDCVWGVHVQEEKRILLQVEILNVREG 463
T A+C S P G + S D+P + +C + V V + LQV+ +N+ +G
Sbjct: 273 TTEQAPALCSVSFSNPEGYIDSSDYPLLPLNNFLECTYNVTVYTGYGVELQVKSVNLSDG 332
Query: 464 DMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKE 523
++L++ DGP+ VLA + + S +++ F+ + GLG F LH++
Sbjct: 333 ELLSIRGVDGPTLTVLANQTLLVEGQVIRSPTNTISVYFRT---FQDDGLGT-FQLHYQA 388
Query: 524 VPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC--QWDLSWSAA 581
+ P P+ G T DL G V + C GYEL G+ +LTC WS+
Sbjct: 389 FMLSCNFPR--RPDSGDVTVM--DLHSGGVAHFHCHLGYELQGAKMLTCINASKPHWSSQ 444
Query: 582 PPAC 585
P C
Sbjct: 445 EPIC 448
Score = 37.4 bits (85), Expect = 0.056
Identities = 36/111 (32%), Positives = 41/111 (36%), Gaps = 32/111 (28%)
Query: 115 AGPTAPELLTPPPGT-------TAPPPPSPASPGPPLGPEGGEE---------------- 151
A PT P L P T T P P P PGP + E +E
Sbjct: 192 AVPTTPAPLQISPFTSQPYVAHTLPQRPEPGEPGPDMAQEAPQEDTSPMALMDKGENELT 251
Query: 152 --------ETTTTIITTTTVTTTVTSPAYLLSCGFPPRPAHGDVSVTDLHP 194
ETTT+ I TTTV TT +PA L S F + D S L P
Sbjct: 252 GSASEESQETTTSTIITTTVITTEQAPA-LCSVSFSNPEGYIDSSDYPLLP 301
>gi|148839280 seizure related 6 homolog isoform 1 [Homo sapiens]
Length = 994
Score = 674 bits (1739), Expect = 0.0
Identities = 315/635 (49%), Positives = 436/635 (68%), Gaps = 7/635 (1%)
Query: 171 AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS 230
AYLLSC FP RPA+GDV+VT LHPGG+A FHC +GYQL+G L CLN T+P W+ + P
Sbjct: 352 AYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPV 411
Query: 231 CMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290
C+A+CGG I NAT GRIVSP G NLTC W++EA EG+RLHLHFE+VSL ED+DRL
Sbjct: 412 CIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRL 471
Query: 291 MVRSGGSPLSPVIYDS-DMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 349
++R+G + +P +YDS +++ +P GL+S + +VEL +++ ++LR+EAF++
Sbjct: 472 IIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGH 531
Query: 350 CFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPAC 409
C+ PF+ +GN +++ P Y G FSC PGY LE IECVDP +P WN+TEPAC
Sbjct: 532 CYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSI--IIECVDPHDPQWNETEPAC 589
Query: 410 KAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLF 469
+A+C GE+++ AGVVLSP+WP+ Y GQDC+WGVHV+E+KRI+L + +L + GD+LT +
Sbjct: 590 RAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFY 649
Query: 470 DGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT 529
DGD +ARVL Q GP+ +L +S D+T+QFQ+ PG G QGFV+HF EVPRNDT
Sbjct: 650 DGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDT 709
Query: 530 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM 589
CPELP GW++ S +L+ GTV+TYQC PGY+++GS +L CQWDL+WS P+CQ++
Sbjct: 710 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVT 769
Query: 590 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 649
+C DPG++ + R S FPVG+ VQY C G+ L G+++LTC+ R G+PKWSDR PK
Sbjct: 770 SCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPK 829
Query: 650 CAL-KYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 708
C L + +PC PENG ++ K + AG ++ F C G+ L G+ +I CVPGHPS W+
Sbjct: 830 CLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWS 889
Query: 709 SQPPLCKVA-YEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYT 767
PP+C+ A + ++R L+V + S L+ ++A AI LPL +++L GVY Y++
Sbjct: 890 DPPPICRAASLDGFYNSRSLDVAKAPAASSTLDAAHIAAAIFLPLVAMVLLVGGVYFYFS 949
Query: 768 KLQGKSLFGF--SGSHSYSPITVESDFSNPLYEAG 800
+LQGKS Y+ IT+ES F NP YE G
Sbjct: 950 RLQGKSSLQLPRPRPRPYNRITIESAFDNPTYETG 984
Score = 124 bits (311), Expect = 3e-28
Identities = 166/619 (26%), Positives = 244/619 (39%), Gaps = 72/619 (11%)
Query: 37 PEPGSETPTVASEALAELLHGALLRRGPEMGYLPGSDR-DPTLATPPAGQTLAVPS-LPR 94
PE G T A L L H LL + G G + P L P PS LPR
Sbjct: 51 PERGVHFVTTAP-TLKLLNHHPLLEEFLQEGLEKGDEELRPALPFQPDPPAPFTPSPLPR 109
Query: 95 ATEPGTGPLTTAVTP-------NGVRGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPE 147
+ P+ T+ TP GP +PE +P TAP PP P+ P LGP
Sbjct: 110 LANQDSRPVFTSPTPAMAAVPTQPQSKEGPWSPESESPMLRITAPLPPGPSMAVPTLGP- 168
Query: 148 GGEEETTTTIITTTTVTTTVTSPAYLLSCGFPPRPAHGDVSVTDLHPG--GTATFHCDSG 205
GE +TT + T T P G RP +V G GT T SG
Sbjct: 169 -GEIASTTP--PSRAWTPTQEGP------GDMGRPWVAEVVSQGAGIGIQGTITSSTASG 219
Query: 206 YQLQGEETLICLNGTRP--------SWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVG 257
+ T + T SWN P G++ + T + SP G
Sbjct: 220 DDEETTTTTTIITTTITTVQTPGPCSWNFSGPE------GSLDSPT--DLSSPTDVG--- 268
Query: 258 PNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLI 317
L C + I G + + + +SL E + GG P+ S + RG +
Sbjct: 269 --LDCFFYISVYPGYGVEIKVQNISLREGETVTVEGLGGPDPLPLANQSFL----LRGQV 322
Query: 318 SDAQSLYVELLSET---PANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALAT 374
+ + L ++ PA P ++A+ F A+G+VT T PG A
Sbjct: 323 IRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVT--SLHPGGSAR 380
Query: 375 FSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGEL-SEPAGVVLSPDWPQSY 433
F C GY L+ + C++ T+P W+ EP C A CGG + + G ++SP +P +Y
Sbjct: 381 FHCATGYQLK---GARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNY 437
Query: 434 SPGQDCVWGVHVQEEKRILLQVEILNVRE-GDMLTLFDGDGPSARVLAQLRGPQ--PRRR 490
S C W + E +R+ L E +++ E D L + +GD A + + P
Sbjct: 438 SNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEG 497
Query: 491 LLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIR 550
LLSSG ++ + G G L + E + C E P ++G ++S
Sbjct: 498 LLSSGKHFFVELST----DSSGAAAGMALRY-EAFQQGHCYE-PFVKYGNFSSSTPTYPV 551
Query: 551 GTVLTYQCEPGYEL-LGSDILTC--QWDLSWSAAPPACQKIMTCADPGEIANGHRTASDA 607
GT + + C+PGY L GS I+ C D W+ PAC+ + + GEI +
Sbjct: 552 GTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCS----GEITDSAGVVLSP 607
Query: 608 GFPVGSHVQYRCLPGYSLE 626
+P C+ G +E
Sbjct: 608 NWPEPYGRGQDCIWGVHVE 626
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 196 bits (497), Expect = 9e-50
Identities = 138/420 (32%), Positives = 199/420 (47%), Gaps = 19/420 (4%)
Query: 173 LLSCGFPPRPAHGDVSVTDLHPGGTATFH-CDSGYQLQGEETLICLNGTRPSWNGETPSC 231
L+ C P P +G + H T + C+ GY + G TL CL+G R W+ PSC
Sbjct: 1215 LVKCEDPGIPNYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSC 1274
Query: 232 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 291
+A CGG IH AT GRI+SP NL C W+IEA G+ + LHF + +D L
Sbjct: 1275 IAECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMAHDILK 1334
Query: 292 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 351
V G ++ + +PE + S SL ++ S+ + S++F C
Sbjct: 1335 VWDGPVDSDILLKEWSGSALPE-DIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAATCN 1393
Query: 352 APFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEP-HWNDTEPACK 410
P + N T G TF C PGY L+ I CV W P C
Sbjct: 1394 DPGMPQ-NGTRYGDSREAGDTVTFQCDPGYQLQGQA---KITCVQLNNRFFWQPDPPTCI 1449
Query: 411 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLF 469
A CGG L+ PAGV+LSP++PQ Y PG++C W V V + I L + N+ D L ++
Sbjct: 1450 AACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHIY 1509
Query: 470 DGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT 529
+G+ ++ ++ +G Q R+ SSG L L F++ + GL GF + FKE PR +
Sbjct: 1510 EGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRS---DASVGL-SGFAIEFKEKPR-EA 1564
Query: 530 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPAC 585
C + G R + D G+ +TYQC+ GY++L +TC SW P+C
Sbjct: 1565 CFDPGNIMNGTRVGT--DFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSC 1622
Score = 192 bits (489), Expect = 8e-49
Identities = 134/455 (29%), Positives = 211/455 (46%), Gaps = 32/455 (7%)
Query: 169 SPAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGE 227
S + +C P P +G G T TF CD GYQLQG+ + C+ R W +
Sbjct: 1385 STSIAATCNDPGMPQNGTRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPD 1444
Query: 228 TPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN 287
P+C+A+CGG + G I+SP P C W ++ + L F+ +++
Sbjct: 1445 PPTCIAACGGNL-TGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSY 1503
Query: 288 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEE 347
D L + G SP+I PER + S SL++ S+ ++ F+
Sbjct: 1504 DFLHIYEGEDSNSPLIGSYQGSQAPER-IESSGNSLFLAFRSDASVGLSGFAIEFKEKPR 1562
Query: 348 DRCFAPFLAHGNV---TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTE--PHW 402
+ CF P GN+ T +++ G+ T+ C GY + P ++I CV + P W
Sbjct: 1563 EACFDP----GNIMNGTRVGTDFKLGSTITYQCDSGYKILDP---SSITCVIGADGKPSW 1615
Query: 403 NDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE 462
+ P+C A CGG+ + GVVLSP++P +Y+ GQ C++ + V +E + Q
Sbjct: 1616 DQVLPSCNAPCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTAL 1675
Query: 463 GDMLTLFDGDGPSARVLAQLRGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHF 521
D+ LFDG AR+L+ L G L L++ + L+F A G +GF +
Sbjct: 1676 NDLAELFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSG----ASARGFHFVY 1731
Query: 522 KEVPR-NDT-CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD---- 575
+ VPR +DT C +P P +G R S + G+++ ++C PGY L GS L CQ
Sbjct: 1732 QAVPRTSDTQCSSVPEPRYGRRIGS--EFSAGSIVRFECNPGYLLQGSTALHCQSVPNAL 1789
Query: 576 LSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 610
W+ P+C ++ C+ G T G+P
Sbjct: 1790 AQWNDTIPSC--VVPCS--GNFTQRRGTILSPGYP 1820
Score = 169 bits (429), Expect = 7e-42
Identities = 158/612 (25%), Positives = 249/612 (40%), Gaps = 101/612 (16%)
Query: 173 LLSCGFPPRPAHGDVSVTDLHP-GGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 231
L +C P P++ + + D + +F C+ GY LQG + C+ GT WN +P C
Sbjct: 1913 LAACQEPALPSNS-IKIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLC 1971
Query: 232 MASCGGTIHNATLGRIV-SPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290
+A+CGGT+ +TLG ++ SP G+ NL C W I G H+ F S + ++D L
Sbjct: 1972 IATCGGTL--STLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEANHDFL 2029
Query: 291 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC 350
+++G SP+I D+P L+S + S+ N L ++A+E C
Sbjct: 2030 EIQNGPYHTSPMIGQFSGTDLPA-ALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNC 2088
Query: 351 -FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPAC 409
P +G + +D Y G +F C PGY L G P + C +WN P C
Sbjct: 2089 PDPPPFQNGYMINSD--YSVGQSVSFECYPGYILI--GHP-VLTCQHGINRNWNYPFPRC 2143
Query: 410 KAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRI-----LLQVEILNVREGD 464
A CG ++ G + SP +P Y +DC+W + V + LLQ E +N D
Sbjct: 2144 DAPCGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVN----D 2199
Query: 465 MLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFK-- 522
+ ++DG ++ L G SS + L+F + + G FVL+F
Sbjct: 2200 YIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHS-----DFSNGGFFVLNFHAF 2254
Query: 523 EVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQW--DLSWSA 580
++ + P +P E D G + YQC PGY L+G+DILTC+ L +
Sbjct: 2255 QLKKCQPPPAVPQAEM---LTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEG 2311
Query: 581 APPACQK--------------IMTCADPGEIANGHRTA-------------------SDA 607
+ P C+ I++ PG N + S+
Sbjct: 2312 SLPTCEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEK 2371
Query: 608 GFPV------------------GSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV-- 647
F G+H + ++ + +S D T K ++
Sbjct: 2372 QFDALEVFDGSSGQSPLLVVLSGNHTEQ---SNFTSRSNQLYLRWSTDHATSKKGFKIRY 2428
Query: 648 --PKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGH 703
P C+L + P N G+ L + G + +FC G+ ++G TC P
Sbjct: 2429 AAPYCSLTH-PLKNGGI-------LNRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLG 2480
Query: 704 PSQWTSQPPLCK 715
QW S PLC+
Sbjct: 2481 MYQWDSLTPLCQ 2492
Score = 168 bits (425), Expect = 2e-41
Identities = 167/654 (25%), Positives = 258/654 (39%), Gaps = 94/654 (14%)
Query: 137 PASPGPPLGPEGGEEETTTTIITTT------TVTTTVTSPAYLL----------SCGFPP 180
PAS P +G G + I T T + +S +L+ SC P
Sbjct: 819 PASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVTLESDSCLDPG 878
Query: 181 RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIH 240
P +G D T TF CD GY L +E L+C + WN PSC A CGG I
Sbjct: 879 IPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQ--WNHALPSCDALCGGYIQ 936
Query: 241 NATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLS 300
+ G ++SP +L C W IE + G+ + + F L+ +D L++ GS
Sbjct: 937 GKS-GTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITEDGSFSE 995
Query: 301 PV--IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHG 358
PV + S + + GL + + + +S+ + ++ F ++ + C P +
Sbjct: 996 PVARLTGSVLPHTIKAGLFGNFTA-QLRFISDFSISYEGFNITFSEYDLEPCDDPGVPAF 1054
Query: 359 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELS 418
+ + G TFSC GY LE + C+ W+ P C A CG +
Sbjct: 1055 S-RRIGFHFGVGDSLTFSCFLGYRLEGA---TKLTCLGGGRRVWSAPLPRCVAECGASVK 1110
Query: 419 EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARV 478
G +LSP++P +Y +C++ + + K I L+ + EGD L ++DG S+R
Sbjct: 1111 GNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEGDTLKVYDGKDSSSRP 1170
Query: 479 LAQLRGPQPRRRLLSSGPD-LTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPE 537
L + +L+S + L L+F + QGF L + C + P
Sbjct: 1171 LGTFTKNELLGLILNSTSNHLWLEFNTNGSDTD----QGFQLTYTSFDL-VKCEDPGIPN 1225
Query: 538 WGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS-----WSAAPPACQKIMTC- 591
+G+R G TV+ Y C PGY + GS+ LTC LS W P+C I C
Sbjct: 1226 YGYRIRDEGH-FTDTVVLYSCNPGYAMHGSNTLTC---LSGDRRVWDKPLPSC--IAECG 1279
Query: 592 -------------------------------ADPGEIANGHRTASDAGF----------P 610
ADPG+ + H D P
Sbjct: 1280 GQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMAHDILKVWDGP 1339
Query: 611 VGSHVQYRCLPGYSLEG------AAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 664
V S + + G +L ++ + D K + C +PG+P+
Sbjct: 1340 VDSDILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAATCNDPGMPQ 1399
Query: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVP-GHPSQWTSQPPLCKVA 717
NG T Y +AG+++ F C G++L G+ ITCV + W PP C A
Sbjct: 1400 NG--TRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAA 1451
Score = 164 bits (415), Expect = 3e-40
Identities = 123/438 (28%), Positives = 196/438 (44%), Gaps = 20/438 (4%)
Query: 176 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASC 235
CG P PA+G + + G T TF C + ++L GE + C + W+G PSC+ SC
Sbjct: 528 CGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQ--WSGNKPSCVFSC 585
Query: 236 GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSG 295
A+ G I+SP G N+ C W+I + G R+HL F ++ D L V+
Sbjct: 586 FFNF-TASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAVKDD 644
Query: 296 GSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFL 355
G V+ ++VP + L S + +E S+ ++ + F ++ C P +
Sbjct: 645 GISDITVLGTFSGNEVPSQ-LASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECHDPGI 703
Query: 356 AHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGG 415
D + G+ +F C G+ ++ G + + W+ T P C+A CGG
Sbjct: 704 PINGRRFGD-RFLLGSSVSFHCDDGF-VKTQGSESITCILQDGNVVWSSTVPRCEAPCGG 761
Query: 416 ELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDGDGP 474
L+ +GV+L P WP Y C W + + I + + D L + DG
Sbjct: 762 HLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVNYDTLEVRDGPAS 821
Query: 475 SARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP-RNDTCPEL 533
S+ ++ + G Q + L+S+G + L F N GF++H++ V +D+C +
Sbjct: 822 SSPLIGEYHGTQAPQFLISTGNFMYLLFTT----DNSRSSIGFLIHYESVTLESDSCLDP 877
Query: 534 PPPEWGWRTASHGDL-IRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCA 592
P G R GD IR TV T+ C+PGY L + L C+ + W+ A P+C + C
Sbjct: 878 GIPVNGHRHG--GDFGIRSTV-TFSCDPGYTLSDDEPLVCERNHQWNHALPSCDAL--CG 932
Query: 593 DPGEIANGHRTASDAGFP 610
G I T GFP
Sbjct: 933 --GYIQGKSGTVLSPGFP 948
Score = 162 bits (409), Expect = 2e-39
Identities = 145/600 (24%), Positives = 225/600 (37%), Gaps = 84/600 (14%)
Query: 176 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN--GTRPSWNGETPSCMA 233
C P P +G ++ G F C+ GY LQG L C + WN PSC+
Sbjct: 1742 CSSVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCVV 1801
Query: 234 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 293
C G G I+SP G NL C W I EG + + + +++ D L +
Sbjct: 1802 PCSGNFTQRR-GTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLEIH 1860
Query: 294 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 353
GG +P + VP L S + LY+ S+ L ++ C P
Sbjct: 1861 DGGDVTAPRLGSFSGTTVPAL-LNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQEP 1919
Query: 354 FLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMC 413
L ++ D Y + +F C PGY L+ + I C+ T WN P C A C
Sbjct: 1920 ALPSNSIKIGD-RYMVNDVLSFQCEPGYTLQGR---SHISCMPGTVRRWNYPSPLCIATC 1975
Query: 414 GGELSEPAGVVLSPDWPQSYSPGQDCVW--------GVHVQEEKRILLQVEILNVREGDM 465
GG LS GV+LSP +P SY DC W G H+Q + D
Sbjct: 1976 GGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQ-------FLNFSTEANHDF 2028
Query: 466 LTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP 525
L + +G ++ ++ Q G LLS+ + + F + QGF L ++
Sbjct: 2029 LEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNR----QGFKLAYQAYE 2084
Query: 526 RNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDL--SWSAAPP 583
+ CP+ PP + G+ S D G ++++C PGY L+G +LTCQ + +W+ P
Sbjct: 2085 LQN-CPDPPPFQNGYMINS--DYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFP 2141
Query: 584 ACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCL------PGYSL------------ 625
C C NG T GFP + C+ PG+ +
Sbjct: 2142 RCD--APCGYNVTSQNG--TIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAV 2197
Query: 626 -----------EGAAMLTCYSRDTGTPKWSDRVPKCALKY-------------------E 655
+ + L +S +T + LK+ +
Sbjct: 2198 NDYIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGFFVLNFHAFQLK 2257
Query: 656 PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 715
C P ++ G+ +++ C+ G+ L+G +TC Q+ P C+
Sbjct: 2258 KCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCE 2317
Score = 142 bits (359), Expect = 9e-34
Identities = 170/673 (25%), Positives = 249/673 (36%), Gaps = 112/673 (16%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETPSCM 232
+C P +G TD G T T+ CDSGY++ ++ C+ G +PSW+ PSC
Sbjct: 1564 ACFDPGNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCN 1623
Query: 233 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMV 292
A CGG + + G ++SP C + I + + F
Sbjct: 1624 APCGGQ-YTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQ---------- 1672
Query: 293 RSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFA 352
+ L+ + D R L S + S E L +N +LL ++ R F
Sbjct: 1673 ----TALNDLAELFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFH 1728
Query: 353 PFLAHGNVTTTDP----------------EYRPGALATFSCLPGYALEPPGPPNAIEC-- 394
F+ T+D E+ G++ F C PGY L+ A+ C
Sbjct: 1729 -FVYQAVPRTSDTQCSSVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGS---TALHCQS 1784
Query: 395 VDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQ 454
V WNDT P+C C G ++ G +LSP +P+ Y +C+W + V E I +Q
Sbjct: 1785 VPNALAQWNDTIPSCVVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQ 1844
Query: 455 V-EILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGL 513
V + D L + DG +A L G L S+ L L FQ+
Sbjct: 1845 VISFATEQNWDSLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVA---- 1900
Query: 514 GQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGD-LIRGTVLTYQCEPGYELLGSDILTC 572
GF L +K V C E P + GD + VL++QCEPGY L G ++C
Sbjct: 1901 AAGFHLEYKTVGLA-ACQEPALPS---NSIKIGDRYMVNDVLSFQCEPGYTLQGRSHISC 1956
Query: 573 QWDL--SWSAAPPACQKIMTCAD--------------PGEIANGHRTASDAGFPVG--SH 614
W+ P C I TC PG N P+G +H
Sbjct: 1957 MPGTVRRWNYPSPLC--IATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAH 2014
Query: 615 VQ-------------------YRCLP------GYSLEGAAMLTCYSR------DTGTPKW 643
+Q Y P G L A + T + D +
Sbjct: 2015 IQFLNFSTEANHDFLEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQ 2074
Query: 644 SDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGH 703
++ A + + C +P +NGY + Y G+S+ F CY G+ LIG +TC G
Sbjct: 2075 GFKLAYQAYELQNCPDPPPFQNGY--MINSDYSVGQSVSFECYPGYILIGHPVLTCQHGI 2132
Query: 704 PSQWTSQPPLCKV--AYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSG 761
W P C Y N + P E L I L + + G G
Sbjct: 2133 NRNWNYPFPRCDAPCGYNVTSQNGTI-----YSPGFPDEYPILKDCIWL---ITVPPGHG 2184
Query: 762 VYIYYTKLQGKSL 774
VYI +T LQ +++
Sbjct: 2185 VYINFTLLQTEAV 2197
Score = 133 bits (334), Expect = 8e-31
Identities = 128/449 (28%), Positives = 182/449 (40%), Gaps = 49/449 (10%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL--NGTRPSWNGETPSCM 232
+CG P G + T + G + C GY L+G L C+ G SW+ P C
Sbjct: 144 TCGNPGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCR 203
Query: 233 A--SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290
A +CGGT+ T I SP N C W I A G + L F L+E D L
Sbjct: 204 AEGACGGTLRG-TSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYDFL 262
Query: 291 MVRSGGSPL---------SPVIYDSDM------DDVPERGLISDAQ----------SLYV 325
+ +P SPVI + D R +AQ S V
Sbjct: 263 EISGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIELKSRGV 322
Query: 326 ELLSETPANPL--LLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYAL 383
++L + +LS A D C P + R GA FSC Y L
Sbjct: 323 KMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQFSCEDNYVL 382
Query: 384 EPPGPPNAIECVDPTEP--HWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQDCV 440
+ +I C TE W+D P C+A CG L P+GV+ SP++P Y CV
Sbjct: 383 QGS---KSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCV 439
Query: 441 WGVHVQE-EKRILLQVEILNVREG-DMLTLFDGD--GPSARVLAQLRGPQPRRRLLSSGP 496
W + + +K I L E + G D LT+ D G + VL L G ++S
Sbjct: 440 WVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSN 499
Query: 497 DLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTY 556
+ L Q+ +P GF ++E+ + C + P +G RT S + G LT+
Sbjct: 500 QMWLHLQSDDSIGSP----GFKAVYQEIEKGG-CGDPGIPAYGKRTGS--SFLHGDTLTF 552
Query: 557 QCEPGYELLGSDILTCQWDLSWSAAPPAC 585
+C +EL+G ++TCQ + WS P+C
Sbjct: 553 ECPAAFELVGERVITCQQNNQWSGNKPSC 581
Score = 115 bits (289), Expect = 1e-25
Identities = 155/688 (22%), Positives = 247/688 (35%), Gaps = 106/688 (15%)
Query: 176 CGFPPRPAHGDVSVTDL-HPGGTATFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSCM 232
C P P +G + +D G F C+ Y LQG +++ C + T +W+ P C
Sbjct: 349 CPDPGIPENGRRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICR 408
Query: 233 A-SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRR-LHLHFERVSLDEDNDRL 290
A +CG + + G I SP N C WVI + + + L FE L+ D L
Sbjct: 409 ARTCGSNLRGPS-GVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTL 467
Query: 291 MVRSGGS--PLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEED 348
V G V+Y VP+ ++S + +++ L S+ ++ E+
Sbjct: 468 TVGDAGKVGDTRSVLYVLTGSSVPDL-IVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKG 526
Query: 349 RCFAPFL-AHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEP 407
C P + A+G T + G TF C + L I C + W+ +P
Sbjct: 527 GCGDPGIPAYGK--RTGSSFLHGDTLTFECPAAFELVGE---RVITCQQNNQ--WSGNKP 579
Query: 408 ACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDML 466
+C C + +G++LSP++P+ Y +CVW + + RI L +V + D L
Sbjct: 580 SCVFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFL 639
Query: 467 TLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAP--------------------- 505
+ D VL G + +L SSG + L+FQ+
Sbjct: 640 AVKDDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECH 699
Query: 506 -PGPPNPG--------LGQGFVLHFKE-------------------VPRNDTCPELPPPE 537
PG P G LG H + V + T P P
Sbjct: 700 DPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPC 759
Query: 538 WGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM-------T 590
G TAS G ++ PG+ D L C+W + A P KI
Sbjct: 760 GGHLTASSGVIL---------PPGWPGYYKDSLHCEWIIE--AKPGHSIKITFDRFQTEV 808
Query: 591 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV--P 648
D E+ +G ++S +G + + G M ++ D +
Sbjct: 809 NYDTLEVRDGPASSSPL---IGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYE 865
Query: 649 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 708
L+ + CL+PG+P NG++ + + ++ F C G+ L + + C H QW
Sbjct: 866 SVTLESDSCLDPGIPVNGHR--HGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNH--QWN 921
Query: 709 SQPPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTK 768
P C + + V P N I + G GV + +
Sbjct: 922 HALPSCDALCGGYIQGKSGTVLSPGFPDFYPNSLNCTWTI------EVSHGKGVQMIF-- 973
Query: 769 LQGKSLFGFSGSHSYSPITVESDFSNPL 796
F SH Y IT + FS P+
Sbjct: 974 ----HTFHLESSHDYLLITEDGSFSEPV 997
Score = 104 bits (260), Expect = 3e-22
Identities = 128/562 (22%), Positives = 207/562 (36%), Gaps = 41/562 (7%)
Query: 173 LLSCGFPPRPAHGDVSVTD--LHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS 230
L C PP ++ D G + C GY L G + L C ++ + G P+
Sbjct: 2256 LKKCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPT 2315
Query: 231 CMASC-GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDR 289
C A C + + G I+SP G + TC W I+ + + + ++ D
Sbjct: 2316 CEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQFDA 2375
Query: 290 LMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 349
L V G S SP++ + + S + LY+ ++ + +R+ A
Sbjct: 2376 LEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAA---PY 2432
Query: 350 CFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH-WNDTEPA 408
C G+ + C PGY + G NA +P + W+ P
Sbjct: 2433 CSLTHPLKNGGILNRTAGAVGSKVHYFCKPGYRM--VGHSNATCRRNPLGMYQWDSLTPL 2490
Query: 409 CKAM-CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQ--EEKRILLQVEILNVREGDM 465
C+A+ CG S G ++ +C G ++ ++ + Q + L +G
Sbjct: 2491 CQAVSCGIPESPGNGSFTGNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKP 2550
Query: 466 LTLFDGDGPSA----------RVLAQLRGPQPRRRLLSSGPDLTLQ-FQAPPGPPNPGLG 514
T PS R+++ + LLS P L+ ++ N G
Sbjct: 2551 PTCKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQAN---G 2607
Query: 515 QGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQW 574
+ + R +C L P G + + + G + C GY L+GS + C
Sbjct: 2608 TWNIGDERPSCRVISCGSLSFPPNGNKIGTL--TVYGATAIFTCNTGYTLVGSHVRECLA 2665
Query: 575 DLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCY 634
+ WS + C C P I NGH S GF V Y+C PG+ L G ++ C
Sbjct: 2666 NGLWSGSETRC-LAGHCGSPDPIVNGH--ISGDGFSYRDTVVYQCNPGFRLVGTSVRICL 2722
Query: 635 SRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGE 694
KWS + P C C +PG P +G+ + + + F C G+ L G
Sbjct: 2723 Q----DHKWSGQTPVCV--PITCGHPGNPAHGFTN--GSEFNLNDVVNFTCNTGYLLQGV 2774
Query: 695 VTITCVPGHPSQWTSQPPLCKV 716
C QW+S P C+V
Sbjct: 2775 SRAQCRSN--GQWSSPLPTCRV 2794
Score = 97.4 bits (241), Expect = 5e-20
Identities = 137/572 (23%), Positives = 200/572 (34%), Gaps = 112/572 (19%)
Query: 234 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 293
+CGG + G I SP C W+I E R+ L F +L+ED D L V
Sbjct: 31 NCGGLVQGPN-GTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEEDFDILSVY 89
Query: 294 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 353
G + +P ++S L + ++ + +E C P
Sbjct: 90 DGQPQQGNLKVRLSGFQLPS-SIVSTGSILTLWFTTDFAVSAQGFKALYEVLPSHTCGNP 148
Query: 354 F-----LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTE-PHWNDTEP 407
+ HG + G +SCLPGY LE I V P W+ P
Sbjct: 149 GEILKGVLHGT------RFNIGDKIRYSCLPGYILEGHAILTCI--VSPGNGASWDFPAP 200
Query: 408 ACKA--MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-D 464
C+A CGG L + + SP +P Y DC W + + I L + EG D
Sbjct: 201 FCRAEGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYD 260
Query: 465 MLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLH---- 520
L + + PS L + P P ++SS L L F + G F +
Sbjct: 261 FLEISGTEAPSI-WLTGMNLPSP---VISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIE 316
Query: 521 -----FKEVPR------------------NDTCPELPPPEWGWRTASHGDLIRGTVLTYQ 557
K +P +D CP+ PE G R S + G + +
Sbjct: 317 LKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRV-GANVQFS 375
Query: 558 CEPGYELLGSDILTCQ----WDLSWSAAPPACQK-------------------------- 587
CE Y L GS +TCQ +WS P C+
Sbjct: 376 CEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDN 435
Query: 588 -----IMTCADPG----------EIANGH--RTASDAGFPVGSHVQYRCLPG-------Y 623
++T DP E+ G+ T DAG + L G
Sbjct: 436 AHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIV 495
Query: 624 SLEGAAMLTCYSRDT-GTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLR 682
S+ L S D+ G+P + + ++ C +PG+P G +T + G++L
Sbjct: 496 SMSNQMWLHLQSDDSIGSPGF--KAVYQEIEKGGCGDPGIPAYGKRT--GSSFLHGDTLT 551
Query: 683 FFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 714
F C FEL+GE ITC +QW+ P C
Sbjct: 552 FECPAAFELVGERVITCQQN--NQWSGNKPSC 581
Score = 92.0 bits (227), Expect = 2e-18
Identities = 58/184 (31%), Positives = 83/184 (45%), Gaps = 15/184 (8%)
Query: 534 PPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD 593
P P + G R TV+ YQC PG+ L+G+ + C D WS P C I TC
Sbjct: 2684 PDPIVNGHISGDGFSYRDTVV-YQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPI-TCGH 2741
Query: 594 PGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALK 653
PG A+G S+ F + V + C GY L+G + C S +WS +P C +
Sbjct: 2742 PGNPAHGFTNGSE--FNLNDVVNFTCNTGYLLQGVSRAQCRSNG----QWSSPLPTC--R 2793
Query: 654 YEPCLNPGVPENGY---QTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ 710
C +PG EN Q + ++ G S+ + C +GF L+G +TC+ W
Sbjct: 2794 VVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMAN--GLWDRS 2851
Query: 711 PPLC 714
P C
Sbjct: 2852 LPKC 2855
Score = 87.8 bits (216), Expect = 4e-17
Identities = 90/359 (25%), Positives = 143/359 (39%), Gaps = 41/359 (11%)
Query: 356 AHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM-CG 414
AHG+ D ++ +L FSC G+ L G P ++ + W+ +P C+A+ CG
Sbjct: 2928 AHGSRLGDD--FKTKSLLRFSCEMGHQLR--GSPERTCLLNGS---WSGLQPVCEAVSCG 2980
Query: 415 GELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGP 474
+ G+++S D S W + + L R + G P
Sbjct: 2981 NPGTPTNGMIVSSDGILFSSSVIYACWEGY---------KTSGLMTRHCTANGTWTGTAP 3031
Query: 475 SARVLAQLRGPQPRRRLLSSGPDLT----LQFQAPPGPPNPGLGQGFVLHFKEVPRNDT- 529
+++ P + G D T + +Q PG + + K+ N +
Sbjct: 3032 DCTIIS-CGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSK 3090
Query: 530 -------CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAP 582
CP+ PP + G T D G+ ++Y C GY+L S IL+C+ W
Sbjct: 3091 PVCKAVLCPQPPPVQNG--TVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEI 3148
Query: 583 PACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPK 642
P C + C DPG A G S F S V ++C + L G++ C + T
Sbjct: 3149 PQCLPVF-CGDPGIPAEGR--LSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGT---- 3201
Query: 643 WSDRVPKCA-LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCV 700
WS P C + C +PG P G Q Y+ G ++ F C +G+ + G T TC+
Sbjct: 3202 WSGIQPTCIDPAHNTCPDPGTPHFGIQN-SSRGYEVGSTVFFRCRKGYHIQGSTTRTCL 3259
Score = 82.0 bits (201), Expect = 2e-15
Identities = 127/571 (22%), Positives = 196/571 (34%), Gaps = 125/571 (21%)
Query: 174 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMA 233
+SCG P PA+ ++ G + C L G +T +C + W+G P C
Sbjct: 2858 ISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSH--WSGALPHCTG 2915
Query: 234 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAA--EGRRLHLHFERVSLDEDNDRLM 291
+ G G +P G +G + + ++ + G +L ER L
Sbjct: 2916 NNPGFC-----GDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCL-------- 2962
Query: 292 VRSGGSPLSPVIYDSDMDD--VPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 349
+ S L PV + P G+I + + L S + +
Sbjct: 2963 LNGSWSGLQPVCEAVSCGNPGTPTNGMIVSSDGI---LFSSSVIYACWEGYKTSGLMTRH 3019
Query: 350 CFAPFLAHGNVTTTDPEYR------PGALA---------------TFSCLPGYALEPPGP 388
C A+G T T P+ PG LA ++ C PGY +E
Sbjct: 3020 C----TANGTWTGTAPDCTIISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTS 3075
Query: 389 PNAIECVDPTEPHWNDTEPACKA-MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQE 447
I C + WN ++P CKA +C G V D+ S C+ G +
Sbjct: 3076 AT-IRCTK--DGRWNPSKPVCKAVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDGYQLSH 3132
Query: 448 EKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPG 507
+L E V +G++ P F PG
Sbjct: 3133 SA--ILSCEGRGVWKGEI------------------------------PQCLPVFCGDPG 3160
Query: 508 PPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGS 567
P G G +K + + +QC+ + L+GS
Sbjct: 3161 IPAEGRLSGKSFTYK-----------------------------SEVFFQCKSPFILVGS 3191
Query: 568 DILTCQWDLSWSAAPPAC--QKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSL 625
CQ D +WS P C TC DPG G + +S G+ VGS V +RC GY +
Sbjct: 3192 SRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSS-RGYEVGSTVFFRCRKGYHI 3250
Query: 626 EGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFC 685
+G+ TC + T + ++ +P + E + V T G +L + C
Sbjct: 3251 QGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTF-------GYTLVYTC 3303
Query: 686 YEGFELI-GEVTITCVPGHPSQWTSQPPLCK 715
+ GF L G TC +WT + P+CK
Sbjct: 3304 HPGFFLAGGSEHRTCKA--DMKWTGKSPVCK 3332
Score = 78.6 bits (192), Expect = 2e-14
Identities = 53/168 (31%), Positives = 72/168 (42%), Gaps = 13/168 (7%)
Query: 551 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC--QKIMTCADPGEIANGHRTASDAG 608
G V+ Y C L+G+D CQ D WS A P C C DPG A+G R D
Sbjct: 2879 GAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGDD-- 2936
Query: 609 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 668
F S +++ C G+ L G+ TC + WS P C + C NPG P NG
Sbjct: 2937 FKTKSLLRFSCEMGHQLRGSPERTCLLNGS----WSGLQPVC--EAVSCGNPGTPTNG-M 2989
Query: 669 TLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV 716
+ S+ + C+EG++ G +T C WT P C +
Sbjct: 2990 IVSSDGILFSSSVIYACWEGYKTSGLMTRHCTAN--GTWTGTAPDCTI 3035
Score = 67.8 bits (164), Expect = 4e-11
Identities = 51/166 (30%), Positives = 69/166 (41%), Gaps = 12/166 (7%)
Query: 551 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 610
G + Y C+ G+ LLGS LTC + W + P C I +C PG AN T F
Sbjct: 2821 GMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAI-SCGHPGVPANAVLTGE--LFT 2877
Query: 611 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEP-CLNPGVPENGYQT 669
G+ V Y C SL G C WS +P C C +PG P +G +
Sbjct: 2878 YGAVVHYSCRGSESLIGNDTRVCQE----DSHWSGALPHCTGNNPGFCGDPGTPAHG--S 2931
Query: 670 LYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 715
++ LRF C G +L G TC+ W+ P+C+
Sbjct: 2932 RLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLN--GSWSGLQPVCE 2975
Score = 48.1 bits (113), Expect = 3e-05
Identities = 43/143 (30%), Positives = 58/143 (40%), Gaps = 19/143 (13%)
Query: 591 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 650
C DPG A R G VG + + C GY LEGA LTC G WS +P+C
Sbjct: 1046 CDDPGVPAFSRRIGFHFG--VGDSLTFSCFLGYRLEGATKLTCLG--GGRRVWSAPLPRC 1101
Query: 651 ALK--------YEPCLNPGVP---ENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC 699
+ L+P P +N ++ +YK +AG+ + F+L T+
Sbjct: 1102 VAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRT-RSFQLFEGDTLKV 1160
Query: 700 VPGHPSQWTSQPPLCKVAYEELL 722
G S S PL ELL
Sbjct: 1161 YDGKDS---SSRPLGTFTKNELL 1180
Score = 43.5 bits (101), Expect = 8e-04
Identities = 42/179 (23%), Positives = 70/179 (39%), Gaps = 16/179 (8%)
Query: 543 ASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANG-- 600
A GD I +Q E GY+ L ++S + AP M P +
Sbjct: 240 AEPGDTIALVFTDFQLEEGYDFL---------EISGTEAPSIWLTGMNLPSPVISSKNWL 290
Query: 601 --HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCL 658
H T+ G + Q++ L+ + S+D AL + C
Sbjct: 291 RLHFTSDSNHRRKGFNAQFQVKKAIELKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCP 350
Query: 659 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQWTSQPPLCK 715
+PG+PENG + + G +++F C + + L G +ITC V + W+ P+C+
Sbjct: 351 DPGIPENG-RRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICR 408
Score = 43.1 bits (100), Expect = 0.001
Identities = 22/72 (30%), Positives = 37/72 (51%), Gaps = 5/72 (6%)
Query: 174 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC-M 232
++CG P PAHG + ++ + F C++GY LQG C + + W+ P+C +
Sbjct: 2737 ITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQ--WSSPLPTCRV 2794
Query: 233 ASCG--GTIHNA 242
+C G + NA
Sbjct: 2795 VNCSDPGFVENA 2806
Score = 37.0 bits (84), Expect = 0.073
Identities = 28/90 (31%), Positives = 39/90 (43%), Gaps = 5/90 (5%)
Query: 147 EGGEEETTTTIITTTTVTTTVTSP-AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSG 205
EG + T T T T T+P ++SCG P A+G TD T ++ C+ G
Sbjct: 3008 EGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLANGIQFGTDFTFNKTVSYQCNPG 3067
Query: 206 YQLQG--EETLICLNGTRPSWNGETPSCMA 233
Y ++ T+ C R WN P C A
Sbjct: 3068 YVMEAVTSATIRCTKDGR--WNPSKPVCKA 3095
Score = 33.9 bits (76), Expect = 0.62
Identities = 16/68 (23%), Positives = 30/68 (44%), Gaps = 2/68 (2%)
Query: 166 TVTSPAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEE--TLICLNGTRPS 223
++T +SCG P P +G + + + C G++L+ + T +C S
Sbjct: 2486 SLTPLCQAVSCGIPESPGNGSFTGNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWS 2545
Query: 224 WNGETPSC 231
G+ P+C
Sbjct: 2546 NKGKPPTC 2553
Score = 33.9 bits (76), Expect = 0.62
Identities = 21/54 (38%), Positives = 27/54 (50%), Gaps = 7/54 (12%)
Query: 195 GGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMA-SCG--GTIHNATL 244
G + +HC G+ L G L C+ NG W+ P C+A SCG G NA L
Sbjct: 2821 GMSILYHCKKGFYLLGSSALTCMANGL---WDRSLPKCLAISCGHPGVPANAVL 2871
Score = 33.5 bits (75), Expect = 0.81
Identities = 23/75 (30%), Positives = 31/75 (41%), Gaps = 4/75 (5%)
Query: 159 TTTTVTTTVTSPAYLLSCGFPPRPAHG-DVSVTDLHPGGTATFHCDSGYQLQGEETLICL 217
T + + T PA+ +C P P G S G T F C GY +QG T CL
Sbjct: 3201 TWSGIQPTCIDPAHN-TCPDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCL 3259
Query: 218 NGTRPSWNGETPSCM 232
+W+G C+
Sbjct: 3260 --ANLTWSGIQTECI 3272
Score = 32.3 bits (72), Expect = 1.8
Identities = 17/57 (29%), Positives = 30/57 (52%), Gaps = 2/57 (3%)
Query: 742 GNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYE 798
G++A AIL+P +I+ G Y+Y + + K + H S ++ F NP+Y+
Sbjct: 3487 GSVAAAILVPFFALILSGFAFYLYKHRTRPKVQYNGYAGHENS--NGQASFENPMYD 3541
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 194 bits (494), Expect = 2e-49
Identities = 153/558 (27%), Positives = 245/558 (43%), Gaps = 31/558 (5%)
Query: 171 AYLLSCGFPPRP-AHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETP 229
AY L PRP +G V D G T +F C GY L G L CL+G +WN P
Sbjct: 2178 AYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLP 2237
Query: 230 SCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDR 289
C A CGG I A G I SP C W++ G ++++F + + D
Sbjct: 2238 RCEALCGGNI-TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDF 2296
Query: 290 LMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 349
+ V G SP I + E + S + + ++ S+ + + L + A++
Sbjct: 2297 ITVWDGPDQNSPQIGQFSGNTALE-SVYSTSNQILIKFHSDFTTSGFFV-LSYHAYQLRV 2354
Query: 350 CF-APFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAI-ECVDPTEPHWNDTEP 407
C P + + + T D E+ G + + CLPG+ L NAI C + P
Sbjct: 2355 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTL----VGNAILTCRLGERLQMDGAPP 2410
Query: 408 ACKAMC-GGELS-EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNV-REGD 464
C+ +C EL + GV+LSP +P SY Q C W + V++ I + VE +E D
Sbjct: 2411 VCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFD 2470
Query: 465 MLTLFDGDGPSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKE 523
+L ++DG + VL L G + S+G ++ LQ+ A G G ++ +
Sbjct: 2471 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCS 2530
Query: 524 VPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDL----SWS 579
P + PP + + G L +V+ + C+ G+ L+G C+ +W
Sbjct: 2531 TPES-------PPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWD 2581
Query: 580 AAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTG 639
A PACQ I +C P NG +D + VG+ V Y C GY L + T + G
Sbjct: 2582 APVPACQAI-SCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDG 2638
Query: 640 TPKWSDRVPKCALKYEPCLNPGVPENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTIT 698
T ++ P+C + P +N + E+G ++ + HY+ + F C G+ +G +I
Sbjct: 2639 TWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIE 2698
Query: 699 CVPGHPSQWTSQPPLCKV 716
C+P W ++ P C++
Sbjct: 2699 CLPNGTWSWRNERPYCQI 2716
Score = 192 bits (487), Expect = 1e-48
Identities = 168/681 (24%), Positives = 278/681 (40%), Gaps = 87/681 (12%)
Query: 169 SPAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGE 227
S + +C P P +G + PG T F CD GY+LQGEE + C+ R W
Sbjct: 1481 SSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPS 1540
Query: 228 TPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN 287
P C+A CGG + ++ G I+SP + C W I + L F S++ +
Sbjct: 1541 PPVCIAPCGGNLTGSS-GFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNY 1599
Query: 288 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEE 347
D L + G SP+I +PER + S + ++++ S+ + L ++A
Sbjct: 1600 DFLYIYDGPDSNSPLIGSFQDSKLPER-IESSSNTMHLAFRSDGSVSYTGFHLEYKAKLR 1658
Query: 348 DRCFAPFLAHGNV---TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHW 402
+ CF P GN+ T +Y+ G+ T+ C GY L+ + + C+ D P W
Sbjct: 1659 ESCFDP----GNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGY---STLTCIMGDDGRPGW 1711
Query: 403 NDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE 462
N P+C A CG + G VLSP++P++YS G +CV+ + V +E + Q
Sbjct: 1712 NRALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL 1771
Query: 463 GDMLTLFDGDGPSARVLAQLRGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHF 521
D++ ++DG + +L+ L G L LSSG +T++F + P +GF +
Sbjct: 1772 HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTS----VGPITAKGFHFVY 1827
Query: 522 KEVPRNDT--CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC------- 572
+ VPR + C +P P +G R + + G+ + + C PGY L GS + C
Sbjct: 1828 QAVPRTSSTQCSSVPEPRFGRRIGN--EFAVGSSVLFDCNPGYILHGSIAIRCETVPNSL 1885
Query: 573 -QWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF--------PVGSHVQYRCLPGY 623
QW+ S C I+T ++ G+ D P G+ +Q + + +
Sbjct: 1886 AQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVV-SF 1944
Query: 624 SLE--------------GAAMLTCYS--------------------RDTGTPKWSDRVPK 649
+ E A L YS D +
Sbjct: 1945 ATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEY 2004
Query: 650 CALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTS 709
A+ + C P P +G + Y G+ + F C +G+ L G ITC+PG +W
Sbjct: 2005 TAIGLDSCPEPQTPSSGIK--IGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNY 2062
Query: 710 QPPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKL 769
P+C + + + P + I LP+G GV++ +
Sbjct: 2063 PIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGF------GVHLQFVNF 2116
Query: 770 QGKSLFGF----SGSHSYSPI 786
+++ + SGS S +
Sbjct: 2117 STETIHDYLEVRSGSSETSTV 2137
Score = 180 bits (456), Expect = 5e-45
Identities = 157/595 (26%), Positives = 249/595 (41%), Gaps = 74/595 (12%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMAS 234
SC P P HG D G T +F CDSGY+L EE L+C W+ P+C A
Sbjct: 969 SCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHW--WSHPLPTCDAL 1026
Query: 235 CGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRS 294
CGG + + G I+SP +L C W ++ G+ + +F L++ +D L++
Sbjct: 1027 CGGDVRGPS-GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITE 1085
Query: 295 GGSPLSPV--IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFA 352
GS P+ + SD+ GL + ++ + +S+ + ++ F + + C
Sbjct: 1086 NGSFTQPLARLTGSDLPPTINAGLYGNFRA-QLRFISDFSISYEGFNITFSEYNLEPCED 1144
Query: 353 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM 412
P + + + G TFSC GY LE + I C+ W+ P C A
Sbjct: 1145 PGIPQYG-SRIGFNFGIGDTLTFSCSSGYRLEGT---SEIICLGGGRRVWSAPLPRCVAE 1200
Query: 413 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGD 472
CG + G++LSP++P +Y +C++ + VQ K I + ++ +GD+L ++DG
Sbjct: 1201 CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGK 1260
Query: 473 GPSARVLAQLRGPQPRRRLLSS-GPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 531
+ +L G R LSS L L+F + G +GF L + + C
Sbjct: 1261 DKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNS----DTEGTDEGFQLVYTSFELSH-CE 1315
Query: 532 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQKIM 589
+ P++G++ + G G+ + Y C PGY L GS +L C +W P+C I
Sbjct: 1316 DPGIPQFGYKISDQGH-FAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC--IA 1372
Query: 590 TCADPGEIANGHRTASDAGFPVGSHVQYRCL------PG--YSLEGAAMLTCYSRDT--- 638
C + + R S G+P RC+ PG SL+ A T S D
Sbjct: 1373 ECGGRFKGESSGRILS-PGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRV 1431
Query: 639 -GTPKWSDRVPK--------------------------------CALKYE-----PCLNP 660
P +D + K A+++ C +P
Sbjct: 1432 WDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDP 1491
Query: 661 GVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ-WTSQPPLC 714
GVP NG T + G+++ F C G+EL GE ITC+ W PP+C
Sbjct: 1492 GVPMNG--TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1544
Score = 174 bits (440), Expect = 4e-43
Identities = 152/596 (25%), Positives = 233/596 (39%), Gaps = 73/596 (12%)
Query: 175 SCGFPPRPAHGDVSVTDLHP-GGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMA 233
SC P P+ G + + D + G +F CD GY LQG + C+ G WN P C+A
Sbjct: 2011 SCPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLA 2069
Query: 234 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 293
CGG + + + G I+SP G +L C W I G +HL F S + +D L VR
Sbjct: 2070 QCGGAMSDFS-GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVR 2128
Query: 294 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 353
SG S S VI +P L S + S+ N + ++A++ C P
Sbjct: 2129 SGSSETSTVIGRLSGPQIPS-SLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDP 2187
Query: 354 F-LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM 412
+G V D + G +F C PGY L +A+ C+ +WN P C+A+
Sbjct: 2188 RPFRNGFVIGND--FTVGQTISFECFPGYTLIGN---SALTCLHGVSRNWNHPLPRCEAL 2242
Query: 413 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-GDMLTLFDG 471
CGG ++ G + SP +P Y QDC W V V I + +L D +T++DG
Sbjct: 2243 CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDG 2302
Query: 472 DGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 531
++ + Q G + S+ + ++F + GF + + C
Sbjct: 2303 PDQNSPQIGQFSGNTALESVYSTSNQILIKFH------SDFTTSGFFVLSYHAYQLRVCQ 2356
Query: 532 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQ--- 586
PP + G ++ YQC PG+ L+G+ ILTC+ L APP CQ
Sbjct: 2357 PPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLC 2416
Query: 587 -----------------------KIMTCADPGEIANGHRTA-------SDAGFPV----- 611
+ CA + G+ ++ F V
Sbjct: 2417 PANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYD 2476
Query: 612 GSHVQ----------YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPG 661
G ++Q Y + G + +S D G K R+ A C P
Sbjct: 2477 GPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY---CSTPE 2533
Query: 662 VPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS--QWTSQPPLCK 715
P +GY + + Q +R+ C GF L+G+ + C W + P C+
Sbjct: 2534 SPPHGY-IISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2588
Score = 161 bits (407), Expect = 3e-39
Identities = 145/598 (24%), Positives = 236/598 (39%), Gaps = 78/598 (13%)
Query: 176 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSCMA 233
C P P G + G + F C+ GY L G + C + + WN P+C+
Sbjct: 1838 CSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIV 1897
Query: 234 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 293
CGG + G I+SP NL C W I EG + + + + + D L
Sbjct: 1898 PCGGILTKRK-GTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFY 1956
Query: 294 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 353
GG +P + +P L S + +LY+ S+ + L + A D C P
Sbjct: 1957 DGGDNNAPRLGSYSGTTIPHL-LNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEP 2015
Query: 354 FLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMC 413
+ D Y G + +F C GY+L+ + I C+ WN P C A C
Sbjct: 2016 QTPSSGIKIGD-RYMVGDVVSFQCDQGYSLQ---GHSHITCMPGPVRRWNYPIPICLAQC 2071
Query: 414 GGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQ-VEILNVREGDMLTLFDGD 472
GG +S+ +GV+LSP +P +Y DC W +++ + LQ V D L + G
Sbjct: 2072 GGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGS 2131
Query: 473 GPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPE 532
++ V+ +L GPQ L S+ + +L F + QGF + + + + +CP+
Sbjct: 2132 SETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNK----QGFHIVY-QAYQLQSCPD 2186
Query: 533 LPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS--WSAAPPACQKIMT 590
P G+ + D G ++++C PGY L+G+ LTC +S W+ P C+ +
Sbjct: 2187 PRPFRNGFVIGN--DFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL-- 2242
Query: 591 CADPGEIANGHRTASDAGFP------------------VGSHVQYRCL---PGYSL---- 625
C G I + T G+P G ++ + L P Y
Sbjct: 2243 CG--GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVW 2300
Query: 626 ----EGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQ----- 676
+ + + +S +T + +K+ + +G+ L H YQ
Sbjct: 2301 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKF----HSDFTTSGFFVLSYHAYQLRVCQ 2356
Query: 677 ------------------AGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV 716
G+ +R+ C GF L+G +TC G Q PP+C+V
Sbjct: 2357 PPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQV 2414
Score = 155 bits (391), Expect = 2e-37
Identities = 115/438 (26%), Positives = 186/438 (42%), Gaps = 18/438 (4%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMAS 234
SCG P P +G F C G++L GE++++C + W+ P C+
Sbjct: 623 SCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ--WSANIPICIFP 680
Query: 235 CGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRS 294
C A +G ++SP+ G NL C W I + G R+HL F L+ D L V+
Sbjct: 681 CLSNF-TAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKD 739
Query: 295 GGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPF 354
G SP SP++ +VP L S++ L +E ++ + ++ + F + C P
Sbjct: 740 GDSPESPILGTFTGAEVPSH-LTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPG 798
Query: 355 LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCG 414
+ N ++ G+ + C G+ ++ G + + W+ P C A CG
Sbjct: 799 IPI-NARRFGDNFQLGSSISVICEEGF-IKTQGTETITCILMDGKVMWSGLIPKCGAPCG 856
Query: 415 GELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDG 473
G S P+GV+LSP WP Y +C W + + I + E D+L + DG
Sbjct: 857 GHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPN 916
Query: 474 PSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRND-TCPE 532
+ +L G Q + L SS + L F N GF +H++ V N +C +
Sbjct: 917 LLSPLLGSYNGTQVPQFLFSSSNFIYLLFTT----DNSRSNNGFKIHYESVTVNTYSCLD 972
Query: 533 LPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCA 592
P G R D G+ +++ C+ GY L + L C+ + WS P C + C
Sbjct: 973 PGIPVHGRRYGH--DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL--CG 1028
Query: 593 DPGEIANGHRTASDAGFP 610
G++ T G+P
Sbjct: 1029 --GDVRGPSGTILSPGYP 1044
Score = 148 bits (373), Expect = 2e-35
Identities = 121/455 (26%), Positives = 188/455 (41%), Gaps = 23/455 (5%)
Query: 173 LLSCGFPPRPAHG-DVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 231
L C P P G +S G T + C+ GY L G L C+ G R +W+ PSC
Sbjct: 1311 LSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC 1370
Query: 232 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 291
+A CGG + GRI+SP NL C W+IE G + L F + +D L
Sbjct: 1371 IAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILR 1430
Query: 292 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 351
V G ++ + +PE G+ S + ++ ++ + +++F + C
Sbjct: 1431 VWDGPPENDMLLKEISGSLIPE-GIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACR 1489
Query: 352 APFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH-WNDTEPACK 410
P + N T PG F C PGY L+ I C+ + W + P C
Sbjct: 1490 DPGVPM-NGTRNGDGREPGDTVVFQCDPGYELQ---GEERITCIQVENRYFWQPSPPVCI 1545
Query: 411 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLF 469
A CGG L+ +G +LSP++P Y +DC W + V + I L ++ D L ++
Sbjct: 1546 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIY 1605
Query: 470 DGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT 529
DG ++ ++ + + R+ SS + L F++ GF L +K R ++
Sbjct: 1606 DGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSY----TGFHLEYKAKLR-ES 1660
Query: 530 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPAC 585
C P T D G+ +TY C+ GY L G LTC W+ A P+C
Sbjct: 1661 C--FDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1718
Query: 586 QKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCL 620
C + G T +P V + C+
Sbjct: 1719 H--APCGSRSTGSEG--TVLSPNYPKNYSVGHNCV 1749
Score = 145 bits (367), Expect = 1e-34
Identities = 164/663 (24%), Positives = 249/663 (37%), Gaps = 86/663 (12%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETPSCM 232
SC P +G D G T T++CD+GY LQG TL C+ G RP WN PSC
Sbjct: 1660 SCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH 1719
Query: 233 ASCGGTIHNATLGRIVSPE--PGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290
A CG + G ++SP +VG N + F + SL +D +
Sbjct: 1720 APCGSR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL---HDVV 1775
Query: 291 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAF---EE 347
V G + S ++ E +S + + S P ++A
Sbjct: 1776 EVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSS 1835
Query: 348 DRCFA-PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIEC--VDPTEPHWND 404
+C + P G E+ G+ F C PGY L AI C V + WND
Sbjct: 1836 TQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGYILHGS---IAIRCETVPNSLAQWND 1890
Query: 405 TEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQV-EILNVREG 463
+ P C CGG L++ G +LSP +P+ Y +CVW + V E I +QV
Sbjct: 1891 SLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNW 1950
Query: 464 DMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKE 523
D L +DG +A L G L S+ +L L FQ+ GF L +
Sbjct: 1951 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVS----AAGFHLEYTA 2006
Query: 524 VPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAA 581
+ D+CPE P G + + G V+++QC+ GY L G +TC W+
Sbjct: 2007 IGL-DSCPEPQTPSSGIKIGDR--YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYP 2063
Query: 582 PPACQK------------IMTCADPGEIANGHRTASDAGFPVGS--HVQYRCLPGYSLEG 627
P C I++ PG + P+G H+Q+ ++
Sbjct: 2064 IPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHD 2123
Query: 628 AAMLTCYSRDTGTP-------------------------------KWSDRVPKCALKYEP 656
+ S +T T K + A + +
Sbjct: 2124 YLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS 2183
Query: 657 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV 716
C +P NG+ + + + G+++ F C+ G+ LIG +TC+ G W P C
Sbjct: 2184 CPDPRPFRNGF--VIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRC-- 2239
Query: 717 AYEELLDNRKLEVTQTT--DPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSL 774
E L + T P E N L + + G+G+YI +T LQ + +
Sbjct: 2240 ---EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWL---VRVPPGNGIYINFTVLQTEPI 2293
Query: 775 FGF 777
+ F
Sbjct: 2294 YDF 2296
Score = 122 bits (307), Expect = 1e-27
Identities = 105/424 (24%), Positives = 179/424 (42%), Gaps = 32/424 (7%)
Query: 176 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSC-M 232
C P P +G +D G T F CD Y LQG +++ C + +W+ P C +
Sbjct: 446 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 505
Query: 233 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRR-LHLHFERVSLDEDNDRLM 291
+CG + + G SP N C WVI A + + ++FE L+ D L
Sbjct: 506 KTCGSNLQGPS-GTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564
Query: 292 VRSGGSPLSP-----VIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFE 346
+ GG P V+ S + D+ ++S + +++ L ++ + + ++ E
Sbjct: 565 IGDGGEVGDPRTVLQVLTGSFVPDL----IVSMSSQMWLHLQTDESVGSVGFKVNYKEIE 620
Query: 347 EDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 406
++ C P + D + + F C G+ L +I C + + W+
Sbjct: 621 KESCGDPGTPLYGIREGD-GFSNRDVLRFECQFGFELI---GEKSIVCQENNQ--WSANI 674
Query: 407 PACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDM 465
P C C + P G VLSPD+P+ Y +C+W + RI L ++ + D
Sbjct: 675 PICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDF 734
Query: 466 LTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP 525
L + DGD P + +L G + L S+ L L+FQA + G+GF + +
Sbjct: 735 LAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQA----DHSMSGRGFNITYNTFG 790
Query: 526 RNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGY-ELLGSDILTC---QWDLSWSAA 581
N+ CP+ P R + L G+ ++ CE G+ + G++ +TC + WS
Sbjct: 791 HNE-CPDPGIPINARRFGDNFQL--GSSISVICEEGFIKTQGTETITCILMDGKVMWSGL 847
Query: 582 PPAC 585
P C
Sbjct: 848 IPKC 851
Score = 94.7 bits (234), Expect = 3e-19
Identities = 60/170 (35%), Positives = 83/170 (48%), Gaps = 15/170 (8%)
Query: 547 DLIRGTVLTYQCEPGY--ELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTA 604
D + G ++Y C+PGY EL GS I TC + +WS P C+ + TC P +I+NG
Sbjct: 3148 DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV-TCPTPPQISNGRLEG 3206
Query: 605 SDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 664
++ F G + Y C PGY L A+LTC G WS VP+C K+ C +PG+P
Sbjct: 3207 TN--FDWGFSISYICSPGYELSFPAVLTC----VGNGTWSGEVPQCLPKF--CGDPGIPA 3258
Query: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 714
G + YQ+ + F C F L+G T C W+ P C
Sbjct: 3259 QGKREGKSFIYQS--EVSFSCNFPFILVGSSTRICQA--DGTWSGSSPHC 3304
Score = 88.2 bits (217), Expect = 3e-17
Identities = 61/189 (32%), Positives = 87/189 (46%), Gaps = 16/189 (8%)
Query: 529 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 588
TC + P G R S+ + + Y C+ GY L GS+ TC + SW+ P C K
Sbjct: 3015 TCGDPGTPGHGSRQESN--FRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC-KA 3071
Query: 589 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 648
+ C +PG ANG D G S V Y C+ GY L G ++ C + T WS +P
Sbjct: 3072 VQCGNPGTTANGKVFRID-GTTFSSSVIYSCMEGYILSGPSVRQCTANGT----WSGTLP 3126
Query: 649 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGF--ELIGEVTITCVPGHPSQ 706
C + C +PG+P NG + Y Y G+++ + C G+ EL G TC
Sbjct: 3127 NCTI--ISCGDPGIPANGLR--YGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTIN--GT 3180
Query: 707 WTSQPPLCK 715
W+ P C+
Sbjct: 3181 WSGVMPTCR 3189
Score = 84.0 bits (206), Expect = 5e-16
Identities = 59/190 (31%), Positives = 81/190 (42%), Gaps = 12/190 (6%)
Query: 527 NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 586
N + P +P HG+ GTV+ Y C PGY L GS +L CQ + W P C
Sbjct: 2892 NCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2951
Query: 587 KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 646
I C PG N S + GS V Y C SL G + TC WS
Sbjct: 2952 MI-DCGHPGVPPNA--VLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG----HWSGS 3004
Query: 647 VPKCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS 705
P C+ C +PG P G+ + + +++ ++R+ C G+ L G TC+
Sbjct: 3005 QPHCSGDATGTCGDPGTP--GHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLAN--G 3060
Query: 706 QWTSQPPLCK 715
WT + P CK
Sbjct: 3061 SWTGRQPECK 3070
Score = 83.2 bits (204), Expect = 9e-16
Identities = 62/187 (33%), Positives = 82/187 (43%), Gaps = 13/187 (6%)
Query: 529 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 588
TCP P G ++ D G ++Y C PGYEL +LTC + +WS P C
Sbjct: 3192 TCPTPPQISNGRLEGTNFDW--GFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP- 3248
Query: 589 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 648
C DPG A G R F S V + C + L G++ C + T WS P
Sbjct: 3249 KFCGDPGIPAQGKREGK--SFIYQSEVSFSCNFPFILVGSSTRICQADGT----WSGSSP 3302
Query: 649 KCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 707
C + C NPGVP +G Q +Q G ++F C +G L G T TC+P W
Sbjct: 3303 HCIEPTQTSCENPGVPRHGSQN-NTFGFQVGSVVQFHCKKGHLLQGSTTRTCLP--DLTW 3359
Query: 708 TSQPPLC 714
+ P C
Sbjct: 3360 SGIQPEC 3366
Score = 82.4 bits (202), Expect = 2e-15
Identities = 53/167 (31%), Positives = 74/167 (44%), Gaps = 14/167 (8%)
Query: 550 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF 609
R TV+ YQC PG+ L+GS + CQ D +WS P+C + +C PG G S GF
Sbjct: 2796 RDTVV-YQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV-SCGHPGSPIYGR--TSGNGF 2851
Query: 610 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT 669
V + C GY ++G C + +WS P C K C +PG+P N +
Sbjct: 2852 NFNDVVTFSCNIGYLMQGPTKAQCQA----NRQWSHPPPMC--KVVNCSDPGIPANSKRE 2905
Query: 670 LYKHH--YQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 714
H + G + + C G+ L G + C P QW P C
Sbjct: 2906 SKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN--GQWDKPLPEC 2950
Score = 68.2 bits (165), Expect = 3e-11
Identities = 61/259 (23%), Positives = 104/259 (40%), Gaps = 12/259 (4%)
Query: 234 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 293
+CGGT+ G I SP C WVI A E R+ + F+ +L+E+ D L +
Sbjct: 24 TCGGTLKGLN-GTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLY 82
Query: 294 SGGSPLSPVIYDSDMDDVPERGLISDAQSLY-VELLSETPANPLLLSLRFEAFEEDRCFA 352
G P + + + ++ +S++ + L S+ + + +E + C
Sbjct: 83 DGHP--HPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 140
Query: 353 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHWNDTEPACK 410
P + V + G +SC+ GY L+ G P + C+ W+ P C+
Sbjct: 141 PGVPPKGVLY-GTRFDVGDKIRYSCVTGYILD--GHPQ-LTCIANSVNTASWDFPVPICR 196
Query: 411 A--MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTL 468
A CGG + +G++ SP +P Y DC W + + I L + E
Sbjct: 197 AEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLE 256
Query: 469 FDGDGPSARVLAQLRGPQP 487
+G P L+ + P P
Sbjct: 257 IEGSEPPTIWLSGMNIPPP 275
Score = 67.8 bits (164), Expect = 4e-11
Identities = 51/188 (27%), Positives = 80/188 (42%), Gaps = 15/188 (7%)
Query: 529 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 588
+C ELP P G + + G+ + C+ G+ L+GS + C WS + C
Sbjct: 2718 SCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRC-LA 2774
Query: 589 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 648
C P I NG + G+ V Y+C PG+ L G+++ C WS ++P
Sbjct: 2775 GHCGIPELIVNGQVIGENYGY--RDTVVYQCNPGFRLIGSSVRICQQ----DHNWSGQLP 2828
Query: 649 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 708
C C +PG P G + + + + + F C G+ + G C QW+
Sbjct: 2829 SCV--PVSCGHPGSPIYGRTS--GNGFNFNDVVTFSCNIGYLMQGPTKAQCQANR--QWS 2882
Query: 709 SQPPLCKV 716
PP+CKV
Sbjct: 2883 HPPPMCKV 2890
Score = 60.5 bits (145), Expect = 6e-09
Identities = 49/161 (30%), Positives = 72/161 (44%), Gaps = 10/161 (6%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETPSCM 232
SCG P P G + T G + C +GY L G L C+ + SW+ P C
Sbjct: 137 SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 196
Query: 233 A--SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290
A +CGGT+ ++ G I SP N C W I A G + L F ++E D L
Sbjct: 197 AEDACGGTMRGSS-GIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYL 255
Query: 291 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSET 331
+ G P P I+ S M+ P +IS+ L + ++++
Sbjct: 256 EI-EGSEP--PTIWLSGMNIPPP--IISNKNWLRLHFVTDS 291
Score = 57.0 bits (136), Expect = 7e-08
Identities = 53/212 (25%), Positives = 83/212 (39%), Gaps = 14/212 (6%)
Query: 413 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDG 471
CGG L G + SP +P Y G +C W + +E RI + + + E D L+L+DG
Sbjct: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84
Query: 472 DGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 531
+L G + S+ +L+ + GF ++++E+ ++ +C
Sbjct: 85 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVS----AHGFKVYYEEL-QSSSCG 139
Query: 532 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD----LSWSAAPPACQK 587
P G + D+ G + Y C GY L G LTC + SW P C+
Sbjct: 140 NPGVPPKGVLYGTRFDV--GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197
Query: 588 IMTCADPGEIANGHRTASDAGFPVGSHVQYRC 619
C G + S FP H C
Sbjct: 198 EDACG--GTMRGSSGIISSPSFPNEYHNNADC 227
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/63 (44%), Positives = 33/63 (52%), Gaps = 2/63 (3%)
Query: 591 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 650
C DPGE NG R SD F +GS VQ+ C Y L+GA +TC WSD P C
Sbjct: 446 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503
Query: 651 ALK 653
+K
Sbjct: 504 KVK 506
Score = 52.0 bits (123), Expect = 2e-06
Identities = 40/130 (30%), Positives = 59/130 (45%), Gaps = 14/130 (10%)
Query: 525 PRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPA 584
P +C P G + + G + G+V+ + C+ G+ L GS TC DL+WS P
Sbjct: 3307 PTQTSCENPGVPRHGSQNNTFGFQV-GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPE 3365
Query: 585 CQKIMTCADPGEIANGHRTASDAGFPVGSH---VQYRCLPGYSLEGAA-MLTCYSRDTGT 640
C +C P A+ A+ G + SH + Y C PG+ L G C S +T
Sbjct: 3366 CIP-HSCKQPETPAH----ANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNT-- 3418
Query: 641 PKWSDRVPKC 650
W+ +VP C
Sbjct: 3419 --WTGKVPIC 3426
Score = 51.6 bits (122), Expect = 3e-06
Identities = 31/77 (40%), Positives = 37/77 (48%), Gaps = 7/77 (9%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMA 233
+CG P P HG ++ T + CD+GY L G E CL NG SW G P C A
Sbjct: 3015 TCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANG---SWTGRQPECKA 3071
Query: 234 -SCG--GTIHNATLGRI 247
CG GT N + RI
Sbjct: 3072 VQCGNPGTTANGKVFRI 3088
Score = 44.3 bits (103), Expect = 5e-04
Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 4/66 (6%)
Query: 652 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPG--HPSQWTS 709
L+ C NPGVP G LY + G+ +R+ C G+ L G +TC+ + + W
Sbjct: 133 LQSSSCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 190
Query: 710 QPPLCK 715
P+C+
Sbjct: 191 PVPICR 196
Score = 44.3 bits (103), Expect = 5e-04
Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 2/61 (3%)
Query: 590 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 649
+C +PG G F VG ++Y C+ GY L+G LTC + T W VP
Sbjct: 137 SCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 194
Query: 650 C 650
C
Sbjct: 195 C 195
Score = 43.9 bits (102), Expect = 6e-04
Identities = 39/148 (26%), Positives = 56/148 (37%), Gaps = 14/148 (9%)
Query: 655 EPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ--WTSQPP 712
E C +PG NG T Y+ G ++ ++C G+ L G T+TC+ G + W P
Sbjct: 1659 ESCFDPGNIMNG--TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716
Query: 713 LCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIV---------LGSGVY 763
C + V P G N +I +P V+ L V
Sbjct: 1717 SCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVE 1776
Query: 764 IYYTKLQGKSLF-GFSGSHSYSPITVES 790
+Y Q SL SGSHS + + S
Sbjct: 1777 VYDGPTQQSSLLSSLSGSHSGESLPLSS 1804
Score = 43.1 bits (100), Expect = 0.001
Identities = 30/99 (30%), Positives = 47/99 (47%), Gaps = 9/99 (9%)
Query: 140 PGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPPRPAHGDVSVTDLHPGGTAT 199
PG + G T T T + V T + ++C PP+ ++G + T+ G + +
Sbjct: 3161 PGYTMELNGSRIRTCTINGTWSGVMPTCRA----VTCPTPPQISNGRLEGTNFDWGFSIS 3216
Query: 200 FHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMAS-CG 236
+ C GY+L L C+ NGT W+GE P C+ CG
Sbjct: 3217 YICSPGYELSFPAVLTCVGNGT---WSGEVPQCLPKFCG 3252
Score = 41.2 bits (95), Expect = 0.004
Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 4/63 (6%)
Query: 652 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQP 711
++ E C +PG P G + + + LRF C GFELIGE +I C +QW++
Sbjct: 619 IEKESCGDPGTPLYGIRE--GDGFSNRDVLRFECQFGFELIGEKSIVCQEN--NQWSANI 674
Query: 712 PLC 714
P+C
Sbjct: 675 PIC 677
Score = 41.2 bits (95), Expect = 0.004
Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 2/81 (2%)
Query: 173 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232
++SCG P P +G+ T G TA F CD G+ L G CL+ W+ C+
Sbjct: 2716 IISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSS--GLWSESETRCL 2773
Query: 233 ASCGGTIHNATLGRIVSPEPG 253
A G G+++ G
Sbjct: 2774 AGHCGIPELIVNGQVIGENYG 2794
Score = 40.4 bits (93), Expect = 0.007
Identities = 22/59 (37%), Positives = 27/59 (45%), Gaps = 3/59 (5%)
Query: 175 SCGFPPRPAHGDVSVT-DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232
SC P P HG + T G FHC G+ LQG T CL +W+G P C+
Sbjct: 3311 SCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDL--TWSGIQPECI 3367
Score = 38.5 bits (88), Expect = 0.025
Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 4/62 (6%)
Query: 657 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQWTSQPPLC 714
C +PG PENG + + G +++F C E + L G +ITC + + W+ P+C
Sbjct: 446 CPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503
Query: 715 KV 716
KV
Sbjct: 504 KV 505
Score = 38.5 bits (88), Expect = 0.025
Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 3/62 (4%)
Query: 176 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-AS 234
CG P +G V + T + C+ G++L G IC +W+G+ PSC+ S
Sbjct: 2777 CGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDH--NWSGQLPSCVPVS 2834
Query: 235 CG 236
CG
Sbjct: 2835 CG 2836
Score = 38.5 bits (88), Expect = 0.025
Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 6/78 (7%)
Query: 173 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGY--QLQGEETLIC-LNGTRPSWNGETP 229
++SCG P PA+G D G ++ C GY +L G C +NGT W+G P
Sbjct: 3130 IISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMP 3186
Query: 230 SCMASCGGTIHNATLGRI 247
+C A T + GR+
Sbjct: 3187 TCRAVTCPTPPQISNGRL 3204
Score = 36.6 bits (83), Expect = 0.096
Identities = 61/252 (24%), Positives = 94/252 (37%), Gaps = 62/252 (24%)
Query: 176 CGFPPRPAHGDV-SVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRP--SWNGETPSCM 232
C P P HG + S T + CD G++L G+ + +C + +W+ P+C
Sbjct: 2529 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2588
Query: 233 A-SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 291
A SC G +P GG LT +++ G R+ D RL
Sbjct: 2589 AISC---------GIPKAPTNGGI----LTTDYLV----GTRV------TYFCNDGYRLS 2625
Query: 292 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 351
+ L+ + SD G S+ ++TP ++ +F
Sbjct: 2626 SKE----LTTAVCQSD-------GTWSNH--------NKTPRCVVVTCPSINSF------ 2660
Query: 352 APFLAHGN---VTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPA 408
L HG V + EY+ + FSC PGY P +IEC+ W + P
Sbjct: 2661 --ILEHGRWRIVNGSHYEYKTKVV--FSCDPGYHGLGPA---SIECLPNGTWSWRNERPY 2713
Query: 409 CKAMCGGELSEP 420
C+ + GEL P
Sbjct: 2714 CQIISCGELPTP 2725
Score = 35.8 bits (81), Expect = 0.16
Identities = 18/58 (31%), Positives = 24/58 (41%), Gaps = 2/58 (3%)
Query: 174 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 231
+SCG P P +G S + TF C+ GY +QG C W+ P C
Sbjct: 2833 VSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQC--QANRQWSHPPPMC 2888
Score = 34.7 bits (78), Expect = 0.36
Identities = 20/67 (29%), Positives = 28/67 (41%), Gaps = 4/67 (5%)
Query: 173 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 231
++ CG P P + +S G T + C L G+ + C LNG W+G P C
Sbjct: 2952 MIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG---HWSGSQPHC 3008
Query: 232 MASCGGT 238
GT
Sbjct: 3009 SGDATGT 3015
Score = 34.3 bits (77), Expect = 0.48
Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 4/61 (6%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGG-TATFHCDSGYQLQ-GEETLICLNGTRPSWNGETPSCM 232
SC P PAH +V DL G T + C G+ L G E +C + +W G+ P C
Sbjct: 3370 SCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDN--TWTGKVPICE 3427
Query: 233 A 233
A
Sbjct: 3428 A 3428
Score = 34.3 bits (77), Expect = 0.48
Identities = 21/75 (28%), Positives = 40/75 (53%), Gaps = 5/75 (6%)
Query: 727 LEVTQTTDPSRQLEGGN---LALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSY 783
L +++ ++ S Q G N +A+AIL+P +I G G Y+Y + K+ ++G +
Sbjct: 3571 LNMSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKT--QYTGCSVH 3628
Query: 784 SPITVESDFSNPLYE 798
++ F NP+Y+
Sbjct: 3629 ENNNGQAAFENPMYD 3643
Score = 31.6 bits (70), Expect = 3.1
Identities = 15/52 (28%), Positives = 27/52 (51%), Gaps = 7/52 (13%)
Query: 542 TASHGDLI------RGTVLTYQCEPGYELLG-SDILTCQWDLSWSAAPPACQ 586
T +H +++ G L Y C+PG+ L G ++ C+ D +W+ P C+
Sbjct: 3376 TPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICE 3427
Score = 31.2 bits (69), Expect = 4.0
Identities = 28/80 (35%), Positives = 35/80 (43%), Gaps = 11/80 (13%)
Query: 173 LLSCGFPPRPAHGDVSVTDLHPG---GTATFH-CDSGYQLQGEETLICL-NGTRPSWNGE 227
+++C P PA+ H GT F+ C+ GY L G LIC NG W+
Sbjct: 2890 VVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNG---QWDKP 2946
Query: 228 TPSC-MASCG--GTIHNATL 244
P C M CG G NA L
Sbjct: 2947 LPECIMIDCGHPGVPPNAVL 2966
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 194 bits (494), Expect = 2e-49
Identities = 153/558 (27%), Positives = 245/558 (43%), Gaps = 31/558 (5%)
Query: 171 AYLLSCGFPPRP-AHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETP 229
AY L PRP +G V D G T +F C GY L G L CL+G +WN P
Sbjct: 2218 AYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLP 2277
Query: 230 SCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDR 289
C A CGG I A G I SP C W++ G ++++F + + D
Sbjct: 2278 RCEALCGGNI-TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDF 2336
Query: 290 LMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 349
+ V G SP I + E + S + + ++ S+ + + L + A++
Sbjct: 2337 ITVWDGPDQNSPQIGQFSGNTALE-SVYSTSNQILIKFHSDFTTSGFFV-LSYHAYQLRV 2394
Query: 350 CF-APFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAI-ECVDPTEPHWNDTEP 407
C P + + + T D E+ G + + CLPG+ L NAI C + P
Sbjct: 2395 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTL----VGNAILTCRLGERLQMDGAPP 2450
Query: 408 ACKAMC-GGELS-EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNV-REGD 464
C+ +C EL + GV+LSP +P SY Q C W + V++ I + VE +E D
Sbjct: 2451 VCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFD 2510
Query: 465 MLTLFDGDGPSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKE 523
+L ++DG + VL L G + S+G ++ LQ+ A G G ++ +
Sbjct: 2511 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCS 2570
Query: 524 VPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDL----SWS 579
P + PP + + G L +V+ + C+ G+ L+G C+ +W
Sbjct: 2571 TPES-------PPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWD 2621
Query: 580 AAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTG 639
A PACQ I +C P NG +D + VG+ V Y C GY L + T + G
Sbjct: 2622 APVPACQAI-SCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDG 2678
Query: 640 TPKWSDRVPKCALKYEPCLNPGVPENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTIT 698
T ++ P+C + P +N + E+G ++ + HY+ + F C G+ +G +I
Sbjct: 2679 TWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIE 2738
Query: 699 CVPGHPSQWTSQPPLCKV 716
C+P W ++ P C++
Sbjct: 2739 CLPNGTWSWRNERPYCQI 2756
Score = 192 bits (487), Expect = 1e-48
Identities = 168/681 (24%), Positives = 278/681 (40%), Gaps = 87/681 (12%)
Query: 169 SPAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGE 227
S + +C P P +G + PG T F CD GY+LQGEE + C+ R W
Sbjct: 1521 SSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPS 1580
Query: 228 TPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN 287
P C+A CGG + ++ G I+SP + C W I + L F S++ +
Sbjct: 1581 PPVCIAPCGGNLTGSS-GFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNY 1639
Query: 288 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEE 347
D L + G SP+I +PER + S + ++++ S+ + L ++A
Sbjct: 1640 DFLYIYDGPDSNSPLIGSFQDSKLPER-IESSSNTMHLAFRSDGSVSYTGFHLEYKAKLR 1698
Query: 348 DRCFAPFLAHGNV---TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHW 402
+ CF P GN+ T +Y+ G+ T+ C GY L+ + + C+ D P W
Sbjct: 1699 ESCFDP----GNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGY---STLTCIMGDDGRPGW 1751
Query: 403 NDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE 462
N P+C A CG + G VLSP++P++YS G +CV+ + V +E + Q
Sbjct: 1752 NRALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL 1811
Query: 463 GDMLTLFDGDGPSARVLAQLRGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHF 521
D++ ++DG + +L+ L G L LSSG +T++F + P +GF +
Sbjct: 1812 HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTS----VGPITAKGFHFVY 1867
Query: 522 KEVPRNDT--CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC------- 572
+ VPR + C +P P +G R + + G+ + + C PGY L GS + C
Sbjct: 1868 QAVPRTSSTQCSSVPEPRFGRRIGN--EFAVGSSVLFDCNPGYILHGSIAIRCETVPNSL 1925
Query: 573 -QWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF--------PVGSHVQYRCLPGY 623
QW+ S C I+T ++ G+ D P G+ +Q + + +
Sbjct: 1926 AQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVV-SF 1984
Query: 624 SLE--------------GAAMLTCYS--------------------RDTGTPKWSDRVPK 649
+ E A L YS D +
Sbjct: 1985 ATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEY 2044
Query: 650 CALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTS 709
A+ + C P P +G + Y G+ + F C +G+ L G ITC+PG +W
Sbjct: 2045 TAIGLDSCPEPQTPSSGIK--IGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNY 2102
Query: 710 QPPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKL 769
P+C + + + P + I LP+G GV++ +
Sbjct: 2103 PIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGF------GVHLQFVNF 2156
Query: 770 QGKSLFGF----SGSHSYSPI 786
+++ + SGS S +
Sbjct: 2157 STETIHDYLEVRSGSSETSTV 2177
Score = 180 bits (456), Expect = 5e-45
Identities = 157/595 (26%), Positives = 249/595 (41%), Gaps = 74/595 (12%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMAS 234
SC P P HG D G T +F CDSGY+L EE L+C W+ P+C A
Sbjct: 1009 SCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHW--WSHPLPTCDAL 1066
Query: 235 CGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRS 294
CGG + + G I+SP +L C W ++ G+ + +F L++ +D L++
Sbjct: 1067 CGGDVRGPS-GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITE 1125
Query: 295 GGSPLSPV--IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFA 352
GS P+ + SD+ GL + ++ + +S+ + ++ F + + C
Sbjct: 1126 NGSFTQPLARLTGSDLPPTINAGLYGNFRA-QLRFISDFSISYEGFNITFSEYNLEPCED 1184
Query: 353 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM 412
P + + + G TFSC GY LE + I C+ W+ P C A
Sbjct: 1185 PGIPQYG-SRIGFNFGIGDTLTFSCSSGYRLEGT---SEIICLGGGRRVWSAPLPRCVAE 1240
Query: 413 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGD 472
CG + G++LSP++P +Y +C++ + VQ K I + ++ +GD+L ++DG
Sbjct: 1241 CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGK 1300
Query: 473 GPSARVLAQLRGPQPRRRLLSS-GPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 531
+ +L G R LSS L L+F + G +GF L + + C
Sbjct: 1301 DKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNS----DTEGTDEGFQLVYTSFELSH-CE 1355
Query: 532 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQKIM 589
+ P++G++ + G G+ + Y C PGY L GS +L C +W P+C I
Sbjct: 1356 DPGIPQFGYKISDQGH-FAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC--IA 1412
Query: 590 TCADPGEIANGHRTASDAGFPVGSHVQYRCL------PG--YSLEGAAMLTCYSRDT--- 638
C + + R S G+P RC+ PG SL+ A T S D
Sbjct: 1413 ECGGRFKGESSGRILS-PGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRV 1471
Query: 639 -GTPKWSDRVPK--------------------------------CALKYE-----PCLNP 660
P +D + K A+++ C +P
Sbjct: 1472 WDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDP 1531
Query: 661 GVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ-WTSQPPLC 714
GVP NG T + G+++ F C G+EL GE ITC+ W PP+C
Sbjct: 1532 GVPMNG--TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1584
Score = 174 bits (440), Expect = 4e-43
Identities = 152/596 (25%), Positives = 233/596 (39%), Gaps = 73/596 (12%)
Query: 175 SCGFPPRPAHGDVSVTDLHP-GGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMA 233
SC P P+ G + + D + G +F CD GY LQG + C+ G WN P C+A
Sbjct: 2051 SCPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLA 2109
Query: 234 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 293
CGG + + + G I+SP G +L C W I G +HL F S + +D L VR
Sbjct: 2110 QCGGAMSDFS-GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVR 2168
Query: 294 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 353
SG S S VI +P L S + S+ N + ++A++ C P
Sbjct: 2169 SGSSETSTVIGRLSGPQIPS-SLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDP 2227
Query: 354 F-LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM 412
+G V D + G +F C PGY L +A+ C+ +WN P C+A+
Sbjct: 2228 RPFRNGFVIGND--FTVGQTISFECFPGYTLIGN---SALTCLHGVSRNWNHPLPRCEAL 2282
Query: 413 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-GDMLTLFDG 471
CGG ++ G + SP +P Y QDC W V V I + +L D +T++DG
Sbjct: 2283 CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDG 2342
Query: 472 DGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 531
++ + Q G + S+ + ++F + GF + + C
Sbjct: 2343 PDQNSPQIGQFSGNTALESVYSTSNQILIKFH------SDFTTSGFFVLSYHAYQLRVCQ 2396
Query: 532 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQ--- 586
PP + G ++ YQC PG+ L+G+ ILTC+ L APP CQ
Sbjct: 2397 PPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLC 2456
Query: 587 -----------------------KIMTCADPGEIANGHRTA-------SDAGFPV----- 611
+ CA + G+ ++ F V
Sbjct: 2457 PANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYD 2516
Query: 612 GSHVQ----------YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPG 661
G ++Q Y + G + +S D G K R+ A C P
Sbjct: 2517 GPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY---CSTPE 2573
Query: 662 VPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS--QWTSQPPLCK 715
P +GY + + Q +R+ C GF L+G+ + C W + P C+
Sbjct: 2574 SPPHGY-IISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2628
Score = 161 bits (407), Expect = 3e-39
Identities = 145/598 (24%), Positives = 236/598 (39%), Gaps = 78/598 (13%)
Query: 176 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSCMA 233
C P P G + G + F C+ GY L G + C + + WN P+C+
Sbjct: 1878 CSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIV 1937
Query: 234 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 293
CGG + G I+SP NL C W I EG + + + + + D L
Sbjct: 1938 PCGGILTKRK-GTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFY 1996
Query: 294 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 353
GG +P + +P L S + +LY+ S+ + L + A D C P
Sbjct: 1997 DGGDNNAPRLGSYSGTTIPHL-LNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEP 2055
Query: 354 FLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMC 413
+ D Y G + +F C GY+L+ + I C+ WN P C A C
Sbjct: 2056 QTPSSGIKIGD-RYMVGDVVSFQCDQGYSLQ---GHSHITCMPGPVRRWNYPIPICLAQC 2111
Query: 414 GGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQ-VEILNVREGDMLTLFDGD 472
GG +S+ +GV+LSP +P +Y DC W +++ + LQ V D L + G
Sbjct: 2112 GGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGS 2171
Query: 473 GPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPE 532
++ V+ +L GPQ L S+ + +L F + QGF + + + + +CP+
Sbjct: 2172 SETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNK----QGFHIVY-QAYQLQSCPD 2226
Query: 533 LPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS--WSAAPPACQKIMT 590
P G+ + D G ++++C PGY L+G+ LTC +S W+ P C+ +
Sbjct: 2227 PRPFRNGFVIGN--DFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL-- 2282
Query: 591 CADPGEIANGHRTASDAGFP------------------VGSHVQYRCL---PGYSL---- 625
C G I + T G+P G ++ + L P Y
Sbjct: 2283 CG--GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVW 2340
Query: 626 ----EGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQ----- 676
+ + + +S +T + +K+ + +G+ L H YQ
Sbjct: 2341 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKF----HSDFTTSGFFVLSYHAYQLRVCQ 2396
Query: 677 ------------------AGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV 716
G+ +R+ C GF L+G +TC G Q PP+C+V
Sbjct: 2397 PPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQV 2454
Score = 155 bits (391), Expect = 2e-37
Identities = 115/438 (26%), Positives = 186/438 (42%), Gaps = 18/438 (4%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMAS 234
SCG P P +G F C G++L GE++++C + W+ P C+
Sbjct: 663 SCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ--WSANIPICIFP 720
Query: 235 CGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRS 294
C A +G ++SP+ G NL C W I + G R+HL F L+ D L V+
Sbjct: 721 CLSNF-TAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKD 779
Query: 295 GGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPF 354
G SP SP++ +VP L S++ L +E ++ + ++ + F + C P
Sbjct: 780 GDSPESPILGTFTGAEVPSH-LTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPG 838
Query: 355 LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCG 414
+ N ++ G+ + C G+ ++ G + + W+ P C A CG
Sbjct: 839 IPI-NARRFGDNFQLGSSISVICEEGF-IKTQGTETITCILMDGKVMWSGLIPKCGAPCG 896
Query: 415 GELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDG 473
G S P+GV+LSP WP Y +C W + + I + E D+L + DG
Sbjct: 897 GHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPN 956
Query: 474 PSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRND-TCPE 532
+ +L G Q + L SS + L F N GF +H++ V N +C +
Sbjct: 957 LLSPLLGSYNGTQVPQFLFSSSNFIYLLFTT----DNSRSNNGFKIHYESVTVNTYSCLD 1012
Query: 533 LPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCA 592
P G R D G+ +++ C+ GY L + L C+ + WS P C + C
Sbjct: 1013 PGIPVHGRRYGH--DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL--CG 1068
Query: 593 DPGEIANGHRTASDAGFP 610
G++ T G+P
Sbjct: 1069 --GDVRGPSGTILSPGYP 1084
Score = 148 bits (373), Expect = 2e-35
Identities = 121/455 (26%), Positives = 188/455 (41%), Gaps = 23/455 (5%)
Query: 173 LLSCGFPPRPAHG-DVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 231
L C P P G +S G T + C+ GY L G L C+ G R +W+ PSC
Sbjct: 1351 LSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC 1410
Query: 232 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 291
+A CGG + GRI+SP NL C W+IE G + L F + +D L
Sbjct: 1411 IAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILR 1470
Query: 292 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 351
V G ++ + +PE G+ S + ++ ++ + +++F + C
Sbjct: 1471 VWDGPPENDMLLKEISGSLIPE-GIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACR 1529
Query: 352 APFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH-WNDTEPACK 410
P + N T PG F C PGY L+ I C+ + W + P C
Sbjct: 1530 DPGVPM-NGTRNGDGREPGDTVVFQCDPGYELQ---GEERITCIQVENRYFWQPSPPVCI 1585
Query: 411 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLF 469
A CGG L+ +G +LSP++P Y +DC W + V + I L ++ D L ++
Sbjct: 1586 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIY 1645
Query: 470 DGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT 529
DG ++ ++ + + R+ SS + L F++ GF L +K R ++
Sbjct: 1646 DGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSY----TGFHLEYKAKLR-ES 1700
Query: 530 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPAC 585
C P T D G+ +TY C+ GY L G LTC W+ A P+C
Sbjct: 1701 C--FDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1758
Query: 586 QKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCL 620
C + G T +P V + C+
Sbjct: 1759 H--APCGSRSTGSEG--TVLSPNYPKNYSVGHNCV 1789
Score = 145 bits (367), Expect = 1e-34
Identities = 164/663 (24%), Positives = 249/663 (37%), Gaps = 86/663 (12%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETPSCM 232
SC P +G D G T T++CD+GY LQG TL C+ G RP WN PSC
Sbjct: 1700 SCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH 1759
Query: 233 ASCGGTIHNATLGRIVSPE--PGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290
A CG + G ++SP +VG N + F + SL +D +
Sbjct: 1760 APCGSR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL---HDVV 1815
Query: 291 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAF---EE 347
V G + S ++ E +S + + S P ++A
Sbjct: 1816 EVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSS 1875
Query: 348 DRCFA-PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIEC--VDPTEPHWND 404
+C + P G E+ G+ F C PGY L AI C V + WND
Sbjct: 1876 TQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGYILHGS---IAIRCETVPNSLAQWND 1930
Query: 405 TEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQV-EILNVREG 463
+ P C CGG L++ G +LSP +P+ Y +CVW + V E I +QV
Sbjct: 1931 SLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNW 1990
Query: 464 DMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKE 523
D L +DG +A L G L S+ +L L FQ+ GF L +
Sbjct: 1991 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVS----AAGFHLEYTA 2046
Query: 524 VPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAA 581
+ D+CPE P G + + G V+++QC+ GY L G +TC W+
Sbjct: 2047 IGL-DSCPEPQTPSSGIKIGDR--YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYP 2103
Query: 582 PPACQK------------IMTCADPGEIANGHRTASDAGFPVGS--HVQYRCLPGYSLEG 627
P C I++ PG + P+G H+Q+ ++
Sbjct: 2104 IPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHD 2163
Query: 628 AAMLTCYSRDTGTP-------------------------------KWSDRVPKCALKYEP 656
+ S +T T K + A + +
Sbjct: 2164 YLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS 2223
Query: 657 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV 716
C +P NG+ + + + G+++ F C+ G+ LIG +TC+ G W P C
Sbjct: 2224 CPDPRPFRNGF--VIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRC-- 2279
Query: 717 AYEELLDNRKLEVTQTT--DPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSL 774
E L + T P E N L + + G+G+YI +T LQ + +
Sbjct: 2280 ---EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWL---VRVPPGNGIYINFTVLQTEPI 2333
Query: 775 FGF 777
+ F
Sbjct: 2334 YDF 2336
Score = 122 bits (307), Expect = 1e-27
Identities = 105/424 (24%), Positives = 179/424 (42%), Gaps = 32/424 (7%)
Query: 176 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSC-M 232
C P P +G +D G T F CD Y LQG +++ C + +W+ P C +
Sbjct: 486 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 545
Query: 233 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRR-LHLHFERVSLDEDNDRLM 291
+CG + + G SP N C WVI A + + ++FE L+ D L
Sbjct: 546 KTCGSNLQGPS-GTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 604
Query: 292 VRSGGSPLSP-----VIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFE 346
+ GG P V+ S + D+ ++S + +++ L ++ + + ++ E
Sbjct: 605 IGDGGEVGDPRTVLQVLTGSFVPDL----IVSMSSQMWLHLQTDESVGSVGFKVNYKEIE 660
Query: 347 EDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 406
++ C P + D + + F C G+ L +I C + + W+
Sbjct: 661 KESCGDPGTPLYGIREGD-GFSNRDVLRFECQFGFELI---GEKSIVCQENNQ--WSANI 714
Query: 407 PACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDM 465
P C C + P G VLSPD+P+ Y +C+W + RI L ++ + D
Sbjct: 715 PICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDF 774
Query: 466 LTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP 525
L + DGD P + +L G + L S+ L L+FQA + G+GF + +
Sbjct: 775 LAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQA----DHSMSGRGFNITYNTFG 830
Query: 526 RNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGY-ELLGSDILTC---QWDLSWSAA 581
N+ CP+ P R + L G+ ++ CE G+ + G++ +TC + WS
Sbjct: 831 HNE-CPDPGIPINARRFGDNFQL--GSSISVICEEGFIKTQGTETITCILMDGKVMWSGL 887
Query: 582 PPAC 585
P C
Sbjct: 888 IPKC 891
Score = 94.7 bits (234), Expect = 3e-19
Identities = 60/170 (35%), Positives = 83/170 (48%), Gaps = 15/170 (8%)
Query: 547 DLIRGTVLTYQCEPGY--ELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTA 604
D + G ++Y C+PGY EL GS I TC + +WS P C+ + TC P +I+NG
Sbjct: 3188 DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV-TCPTPPQISNGRLEG 3246
Query: 605 SDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 664
++ F G + Y C PGY L A+LTC G WS VP+C K+ C +PG+P
Sbjct: 3247 TN--FDWGFSISYICSPGYELSFPAVLTC----VGNGTWSGEVPQCLPKF--CGDPGIPA 3298
Query: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 714
G + YQ+ + F C F L+G T C W+ P C
Sbjct: 3299 QGKREGKSFIYQS--EVSFSCNFPFILVGSSTRICQA--DGTWSGSSPHC 3344
Score = 88.2 bits (217), Expect = 3e-17
Identities = 61/189 (32%), Positives = 87/189 (46%), Gaps = 16/189 (8%)
Query: 529 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 588
TC + P G R S+ + + Y C+ GY L GS+ TC + SW+ P C K
Sbjct: 3055 TCGDPGTPGHGSRQESN--FRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC-KA 3111
Query: 589 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 648
+ C +PG ANG D G S V Y C+ GY L G ++ C + T WS +P
Sbjct: 3112 VQCGNPGTTANGKVFRID-GTTFSSSVIYSCMEGYILSGPSVRQCTANGT----WSGTLP 3166
Query: 649 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGF--ELIGEVTITCVPGHPSQ 706
C + C +PG+P NG + Y Y G+++ + C G+ EL G TC
Sbjct: 3167 NCTI--ISCGDPGIPANGLR--YGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTIN--GT 3220
Query: 707 WTSQPPLCK 715
W+ P C+
Sbjct: 3221 WSGVMPTCR 3229
Score = 84.0 bits (206), Expect = 5e-16
Identities = 59/190 (31%), Positives = 81/190 (42%), Gaps = 12/190 (6%)
Query: 527 NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 586
N + P +P HG+ GTV+ Y C PGY L GS +L CQ + W P C
Sbjct: 2932 NCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2991
Query: 587 KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 646
I C PG N S + GS V Y C SL G + TC WS
Sbjct: 2992 MI-DCGHPGVPPNA--VLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG----HWSGS 3044
Query: 647 VPKCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS 705
P C+ C +PG P G+ + + +++ ++R+ C G+ L G TC+
Sbjct: 3045 QPHCSGDATGTCGDPGTP--GHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLAN--G 3100
Query: 706 QWTSQPPLCK 715
WT + P CK
Sbjct: 3101 SWTGRQPECK 3110
Score = 83.2 bits (204), Expect = 9e-16
Identities = 62/187 (33%), Positives = 82/187 (43%), Gaps = 13/187 (6%)
Query: 529 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 588
TCP P G ++ D G ++Y C PGYEL +LTC + +WS P C
Sbjct: 3232 TCPTPPQISNGRLEGTNFDW--GFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP- 3288
Query: 589 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 648
C DPG A G R F S V + C + L G++ C + T WS P
Sbjct: 3289 KFCGDPGIPAQGKREGK--SFIYQSEVSFSCNFPFILVGSSTRICQADGT----WSGSSP 3342
Query: 649 KCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 707
C + C NPGVP +G Q +Q G ++F C +G L G T TC+P W
Sbjct: 3343 HCIEPTQTSCENPGVPRHGSQN-NTFGFQVGSVVQFHCKKGHLLQGSTTRTCLP--DLTW 3399
Query: 708 TSQPPLC 714
+ P C
Sbjct: 3400 SGIQPEC 3406
Score = 82.4 bits (202), Expect = 2e-15
Identities = 53/167 (31%), Positives = 74/167 (44%), Gaps = 14/167 (8%)
Query: 550 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF 609
R TV+ YQC PG+ L+GS + CQ D +WS P+C + +C PG G S GF
Sbjct: 2836 RDTVV-YQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV-SCGHPGSPIYGR--TSGNGF 2891
Query: 610 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT 669
V + C GY ++G C + +WS P C K C +PG+P N +
Sbjct: 2892 NFNDVVTFSCNIGYLMQGPTKAQCQA----NRQWSHPPPMC--KVVNCSDPGIPANSKRE 2945
Query: 670 LYKHH--YQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 714
H + G + + C G+ L G + C P QW P C
Sbjct: 2946 SKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN--GQWDKPLPEC 2990
Score = 68.6 bits (166), Expect = 2e-11
Identities = 64/269 (23%), Positives = 108/269 (40%), Gaps = 16/269 (5%)
Query: 228 TPSCMA----SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSL 283
T SC+ +CGGT+ G I SP C WVI A E R+ + F+ +L
Sbjct: 54 TVSCVKGFIYTCGGTLKGLN-GTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFAL 112
Query: 284 DEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-VELLSETPANPLLLSLRF 342
+E+ D L + G P + + + ++ +S++ + L S+ + + +
Sbjct: 113 EEEYDYLSLYDGHP--HPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 170
Query: 343 EAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEP 400
E + C P + V + G +SC+ GY L+ G P + C+
Sbjct: 171 EELQSSSCGNPGVPPKGVLY-GTRFDVGDKIRYSCVTGYILD--GHPQ-LTCIANSVNTA 226
Query: 401 HWNDTEPACKA--MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEIL 458
W+ P C+A CGG + +G++ SP +P Y DC W + + I L
Sbjct: 227 SWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDF 286
Query: 459 NVREGDMLTLFDGDGPSARVLAQLRGPQP 487
+ E +G P L+ + P P
Sbjct: 287 QMEEKYDYLEIEGSEPPTIWLSGMNIPPP 315
Score = 67.8 bits (164), Expect = 4e-11
Identities = 51/188 (27%), Positives = 80/188 (42%), Gaps = 15/188 (7%)
Query: 529 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 588
+C ELP P G + + G+ + C+ G+ L+GS + C WS + C
Sbjct: 2758 SCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRC-LA 2814
Query: 589 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 648
C P I NG + G+ V Y+C PG+ L G+++ C WS ++P
Sbjct: 2815 GHCGIPELIVNGQVIGENYGY--RDTVVYQCNPGFRLIGSSVRICQQ----DHNWSGQLP 2868
Query: 649 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 708
C C +PG P G + + + + + F C G+ + G C QW+
Sbjct: 2869 SCV--PVSCGHPGSPIYGRTS--GNGFNFNDVVTFSCNIGYLMQGPTKAQCQANR--QWS 2922
Query: 709 SQPPLCKV 716
PP+CKV
Sbjct: 2923 HPPPMCKV 2930
Score = 60.5 bits (145), Expect = 6e-09
Identities = 49/161 (30%), Positives = 72/161 (44%), Gaps = 10/161 (6%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETPSCM 232
SCG P P G + T G + C +GY L G L C+ + SW+ P C
Sbjct: 177 SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 236
Query: 233 A--SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290
A +CGGT+ ++ G I SP N C W I A G + L F ++E D L
Sbjct: 237 AEDACGGTMRGSS-GIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYL 295
Query: 291 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSET 331
+ G P P I+ S M+ P +IS+ L + ++++
Sbjct: 296 EI-EGSEP--PTIWLSGMNIPPP--IISNKNWLRLHFVTDS 331
Score = 57.0 bits (136), Expect = 7e-08
Identities = 53/212 (25%), Positives = 83/212 (39%), Gaps = 14/212 (6%)
Query: 413 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDG 471
CGG L G + SP +P Y G +C W + +E RI + + + E D L+L+DG
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 124
Query: 472 DGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 531
+L G + S+ +L+ + GF ++++E+ ++ +C
Sbjct: 125 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVS----AHGFKVYYEEL-QSSSCG 179
Query: 532 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD----LSWSAAPPACQK 587
P G + D+ G + Y C GY L G LTC + SW P C+
Sbjct: 180 NPGVPPKGVLYGTRFDV--GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237
Query: 588 IMTCADPGEIANGHRTASDAGFPVGSHVQYRC 619
C G + S FP H C
Sbjct: 238 EDACG--GTMRGSSGIISSPSFPNEYHNNADC 267
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/63 (44%), Positives = 33/63 (52%), Gaps = 2/63 (3%)
Query: 591 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 650
C DPGE NG R SD F +GS VQ+ C Y L+GA +TC WSD P C
Sbjct: 486 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 543
Query: 651 ALK 653
+K
Sbjct: 544 KVK 546
Score = 52.0 bits (123), Expect = 2e-06
Identities = 40/130 (30%), Positives = 59/130 (45%), Gaps = 14/130 (10%)
Query: 525 PRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPA 584
P +C P G + + G + G+V+ + C+ G+ L GS TC DL+WS P
Sbjct: 3347 PTQTSCENPGVPRHGSQNNTFGFQV-GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPE 3405
Query: 585 CQKIMTCADPGEIANGHRTASDAGFPVGSH---VQYRCLPGYSLEGAA-MLTCYSRDTGT 640
C +C P A+ A+ G + SH + Y C PG+ L G C S +T
Sbjct: 3406 CIP-HSCKQPETPAH----ANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNT-- 3458
Query: 641 PKWSDRVPKC 650
W+ +VP C
Sbjct: 3459 --WTGKVPIC 3466
Score = 51.6 bits (122), Expect = 3e-06
Identities = 31/77 (40%), Positives = 37/77 (48%), Gaps = 7/77 (9%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMA 233
+CG P P HG ++ T + CD+GY L G E CL NG SW G P C A
Sbjct: 3055 TCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANG---SWTGRQPECKA 3111
Query: 234 -SCG--GTIHNATLGRI 247
CG GT N + RI
Sbjct: 3112 VQCGNPGTTANGKVFRI 3128
Score = 44.3 bits (103), Expect = 5e-04
Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 4/66 (6%)
Query: 652 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPG--HPSQWTS 709
L+ C NPGVP G LY + G+ +R+ C G+ L G +TC+ + + W
Sbjct: 173 LQSSSCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 230
Query: 710 QPPLCK 715
P+C+
Sbjct: 231 PVPICR 236
Score = 44.3 bits (103), Expect = 5e-04
Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 2/61 (3%)
Query: 590 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 649
+C +PG G F VG ++Y C+ GY L+G LTC + T W VP
Sbjct: 177 SCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 234
Query: 650 C 650
C
Sbjct: 235 C 235
Score = 43.9 bits (102), Expect = 6e-04
Identities = 39/148 (26%), Positives = 56/148 (37%), Gaps = 14/148 (9%)
Query: 655 EPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ--WTSQPP 712
E C +PG NG T Y+ G ++ ++C G+ L G T+TC+ G + W P
Sbjct: 1699 ESCFDPGNIMNG--TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1756
Query: 713 LCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIV---------LGSGVY 763
C + V P G N +I +P V+ L V
Sbjct: 1757 SCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVE 1816
Query: 764 IYYTKLQGKSLF-GFSGSHSYSPITVES 790
+Y Q SL SGSHS + + S
Sbjct: 1817 VYDGPTQQSSLLSSLSGSHSGESLPLSS 1844
Score = 43.1 bits (100), Expect = 0.001
Identities = 30/99 (30%), Positives = 47/99 (47%), Gaps = 9/99 (9%)
Query: 140 PGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPPRPAHGDVSVTDLHPGGTAT 199
PG + G T T T + V T + ++C PP+ ++G + T+ G + +
Sbjct: 3201 PGYTMELNGSRIRTCTINGTWSGVMPTCRA----VTCPTPPQISNGRLEGTNFDWGFSIS 3256
Query: 200 FHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMAS-CG 236
+ C GY+L L C+ NGT W+GE P C+ CG
Sbjct: 3257 YICSPGYELSFPAVLTCVGNGT---WSGEVPQCLPKFCG 3292
Score = 41.2 bits (95), Expect = 0.004
Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 4/63 (6%)
Query: 652 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQP 711
++ E C +PG P G + + + LRF C GFELIGE +I C +QW++
Sbjct: 659 IEKESCGDPGTPLYGIRE--GDGFSNRDVLRFECQFGFELIGEKSIVCQEN--NQWSANI 714
Query: 712 PLC 714
P+C
Sbjct: 715 PIC 717
Score = 41.2 bits (95), Expect = 0.004
Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 2/81 (2%)
Query: 173 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232
++SCG P P +G+ T G TA F CD G+ L G CL+ W+ C+
Sbjct: 2756 IISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSS--GLWSESETRCL 2813
Query: 233 ASCGGTIHNATLGRIVSPEPG 253
A G G+++ G
Sbjct: 2814 AGHCGIPELIVNGQVIGENYG 2834
Score = 40.4 bits (93), Expect = 0.007
Identities = 22/59 (37%), Positives = 27/59 (45%), Gaps = 3/59 (5%)
Query: 175 SCGFPPRPAHGDVSVT-DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232
SC P P HG + T G FHC G+ LQG T CL +W+G P C+
Sbjct: 3351 SCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDL--TWSGIQPECI 3407
Score = 38.5 bits (88), Expect = 0.025
Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 4/62 (6%)
Query: 657 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQWTSQPPLC 714
C +PG PENG + + G +++F C E + L G +ITC + + W+ P+C
Sbjct: 486 CPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 543
Query: 715 KV 716
KV
Sbjct: 544 KV 545
Score = 38.5 bits (88), Expect = 0.025
Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 3/62 (4%)
Query: 176 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-AS 234
CG P +G V + T + C+ G++L G IC +W+G+ PSC+ S
Sbjct: 2817 CGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDH--NWSGQLPSCVPVS 2874
Query: 235 CG 236
CG
Sbjct: 2875 CG 2876
Score = 38.5 bits (88), Expect = 0.025
Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 6/78 (7%)
Query: 173 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGY--QLQGEETLIC-LNGTRPSWNGETP 229
++SCG P PA+G D G ++ C GY +L G C +NGT W+G P
Sbjct: 3170 IISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMP 3226
Query: 230 SCMASCGGTIHNATLGRI 247
+C A T + GR+
Sbjct: 3227 TCRAVTCPTPPQISNGRL 3244
Score = 36.6 bits (83), Expect = 0.096
Identities = 61/252 (24%), Positives = 94/252 (37%), Gaps = 62/252 (24%)
Query: 176 CGFPPRPAHGDV-SVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRP--SWNGETPSCM 232
C P P HG + S T + CD G++L G+ + +C + +W+ P+C
Sbjct: 2569 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2628
Query: 233 A-SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 291
A SC G +P GG LT +++ G R+ D RL
Sbjct: 2629 AISC---------GIPKAPTNGGI----LTTDYLV----GTRV------TYFCNDGYRLS 2665
Query: 292 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 351
+ L+ + SD G S+ ++TP ++ +F
Sbjct: 2666 SKE----LTTAVCQSD-------GTWSNH--------NKTPRCVVVTCPSINSF------ 2700
Query: 352 APFLAHGN---VTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPA 408
L HG V + EY+ + FSC PGY P +IEC+ W + P
Sbjct: 2701 --ILEHGRWRIVNGSHYEYKTKVV--FSCDPGYHGLGPA---SIECLPNGTWSWRNERPY 2753
Query: 409 CKAMCGGELSEP 420
C+ + GEL P
Sbjct: 2754 CQIISCGELPTP 2765
Score = 35.8 bits (81), Expect = 0.16
Identities = 18/58 (31%), Positives = 24/58 (41%), Gaps = 2/58 (3%)
Query: 174 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 231
+SCG P P +G S + TF C+ GY +QG C W+ P C
Sbjct: 2873 VSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQC--QANRQWSHPPPMC 2928
Score = 34.7 bits (78), Expect = 0.36
Identities = 20/67 (29%), Positives = 28/67 (41%), Gaps = 4/67 (5%)
Query: 173 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 231
++ CG P P + +S G T + C L G+ + C LNG W+G P C
Sbjct: 2992 MIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG---HWSGSQPHC 3048
Query: 232 MASCGGT 238
GT
Sbjct: 3049 SGDATGT 3055
Score = 34.3 bits (77), Expect = 0.48
Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 4/61 (6%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGG-TATFHCDSGYQLQ-GEETLICLNGTRPSWNGETPSCM 232
SC P PAH +V DL G T + C G+ L G E +C + +W G+ P C
Sbjct: 3410 SCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDN--TWTGKVPICE 3467
Query: 233 A 233
A
Sbjct: 3468 A 3468
Score = 34.3 bits (77), Expect = 0.48
Identities = 21/75 (28%), Positives = 40/75 (53%), Gaps = 5/75 (6%)
Query: 727 LEVTQTTDPSRQLEGGN---LALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSY 783
L +++ ++ S Q G N +A+AIL+P +I G G Y+Y + K+ ++G +
Sbjct: 3611 LNMSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKT--QYTGCSVH 3668
Query: 784 SPITVESDFSNPLYE 798
++ F NP+Y+
Sbjct: 3669 ENNNGQAAFENPMYD 3683
Score = 31.6 bits (70), Expect = 3.1
Identities = 15/52 (28%), Positives = 27/52 (51%), Gaps = 7/52 (13%)
Query: 542 TASHGDLI------RGTVLTYQCEPGYELLG-SDILTCQWDLSWSAAPPACQ 586
T +H +++ G L Y C+PG+ L G ++ C+ D +W+ P C+
Sbjct: 3416 TPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICE 3467
Score = 31.2 bits (69), Expect = 4.0
Identities = 28/80 (35%), Positives = 35/80 (43%), Gaps = 11/80 (13%)
Query: 173 LLSCGFPPRPAHGDVSVTDLHPG---GTATFH-CDSGYQLQGEETLICL-NGTRPSWNGE 227
+++C P PA+ H GT F+ C+ GY L G LIC NG W+
Sbjct: 2930 VVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNG---QWDKP 2986
Query: 228 TPSC-MASCG--GTIHNATL 244
P C M CG G NA L
Sbjct: 2987 LPECIMIDCGHPGVPPNAVL 3006
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 193 bits (490), Expect = 6e-49
Identities = 127/403 (31%), Positives = 196/403 (48%), Gaps = 15/403 (3%)
Query: 173 LLSCGFPPRPAHGDVSVTDLH-PGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 231
L+ C P P G + H G + +F CD GY L+G E L+CL+G R +W+ P+C
Sbjct: 1208 LIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTC 1267
Query: 232 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 291
+A CGGT+ G+++SP NL C W IEA G + LHF +E +D L
Sbjct: 1268 VAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLR 1327
Query: 292 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 351
+ G ++ + +P + L S S+ ++ ++ + +++F C
Sbjct: 1328 IWDGPVESGVLLKELSGPALP-KDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCN 1386
Query: 352 APFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVD-PTEPHWNDTEPACK 410
P + N + + + G F C PGYAL+ I CV W + P C
Sbjct: 1387 DPGIPQ-NGSRSGDSWEAGDSTVFQCDPGYALQGSA---EISCVKIENRFFWQPSPPTCI 1442
Query: 411 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLF 469
A CGG+L+ P+GV+LSP++P+ Y PG++C W V V + I L I N+ G D L ++
Sbjct: 1443 APCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIY 1502
Query: 470 DGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT 529
DG + ++ G Q R+ SS L L F++ N GFV+ + E PR ++
Sbjct: 1503 DGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSN----AGFVIDYTENPR-ES 1557
Query: 530 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC 572
C + + G R S DL G+ +TY C GYE+ G+ L+C
Sbjct: 1558 CFDPGSIKNGTRVGS--DLKLGSSVTYYCHGGYEVEGTSTLSC 1598
Score = 189 bits (479), Expect = 1e-47
Identities = 164/636 (25%), Positives = 259/636 (40%), Gaps = 73/636 (11%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGETPSCMA 233
SC P P +G S G + F CD GY LQG + C+ R W P+C+A
Sbjct: 1384 SCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIA 1443
Query: 234 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 293
CGG + + G I+SP P C W + + + L F +L+ D L +
Sbjct: 1444 PCGGDLTGPS-GVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIY 1502
Query: 294 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 353
G LSP+I +P R + S + SL++ S+ + + + + CF P
Sbjct: 1503 DGRDSLSPLIGSFYGSQLPGR-IESSSNSLFLAFRSDASVSNAGFVIDYTENPRESCFDP 1561
Query: 354 FLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMC 413
N T + + G+ T+ C GY +E + I D +P WN+ P C A C
Sbjct: 1562 GSIK-NGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDG-KPVWNNPRPVCTAPC 1619
Query: 414 GGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDG 473
GG+ GVVLSP++PQ+Y+ GQ C++ V V ++ + Q + D++ + DG
Sbjct: 1620 GGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVVEVHDGHS 1679
Query: 474 PSARVLAQLRGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT--C 530
+R+L+ L G L L++ + ++F A P +GF ++ VPR C
Sbjct: 1680 QHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAP----ARGFHFVYQAVPRTSATQC 1735
Query: 531 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPACQ 586
+P P +G R S D G ++ ++C GY L GS + C W+ + P C
Sbjct: 1736 SSVPEPRYGKRLGS--DFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTC- 1792
Query: 587 KIMTCADPGEIANGHRTASDAGF----------------PVGSHVQYRCLPGYS------ 624
++ C G + T GF P G+ +Q + + +
Sbjct: 1793 -VVPCG--GNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDS 1849
Query: 625 ---LEGA----------------AMLTCYSRDTGTPKWSDRVPKCA---LKYE-----PC 657
+GA A+L S +SD A L+Y+ C
Sbjct: 1850 LEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSC 1909
Query: 658 LNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVA 717
P VP NG +T Y + + F C G+ L G I+C+PG +W PPLC
Sbjct: 1910 PEPAVPSNGVKT--GERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCIAQ 1967
Query: 718 YEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLG 753
++ + + P + + I LP+G
Sbjct: 1968 CGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVG 2003
Score = 180 bits (456), Expect = 5e-45
Identities = 153/591 (25%), Positives = 245/591 (41%), Gaps = 68/591 (11%)
Query: 176 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASC 235
C P P +G D + G TF CDSGY L E L C + W+ PSC A C
Sbjct: 867 CLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQ--WSRALPSCEALC 924
Query: 236 GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSG 295
GG I ++ G I+SP NL C W+IE + G+ + F L+ +D L++
Sbjct: 925 GGFIQGSS-GTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITEN 983
Query: 296 GSPLSPV--IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 353
GS P+ + S + GL + + V +S+ + ++ F ++ + C P
Sbjct: 984 GSFTQPLRQLTGSRLPAPISAGLYGNFTA-QVRFISDFSMSYEGFNITFSEYDLEPCEEP 1042
Query: 354 FLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMC 413
+ ++ ++ G TFSC PGY LE I C+ W+ P C A C
Sbjct: 1043 EVPAYSIRK-GLQFGVGDTLTFSCFPGYRLEGTA---RITCLGGRRRLWSSPLPRCVAEC 1098
Query: 414 GGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDG 473
G ++ G +LSP++P +Y+ +C++ + Q K I L+ + EGD+L ++DG+
Sbjct: 1099 GNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEGDVLKVYDGNN 1158
Query: 474 PSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPE 532
SAR+L + L S+ L L F +GF LHF C +
Sbjct: 1159 NSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDA----ENTSKGFELHFSSF-ELIKCED 1213
Query: 533 LPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC------QWDLSWSAAPPACQ 586
P++G++ G G+ +++ C+PGY L GS+ L C WD C
Sbjct: 1214 PGTPKFGYKVHDEGH-FAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAECG 1272
Query: 587 KIMTCADPGEIANGHRTA-------------SDAGFPVGSH------------------- 614
+ G++ + A ++AG +G H
Sbjct: 1273 GTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIWDGP 1332
Query: 615 ----VQYRCLPGYSLEG------AAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 664
V + L G +L +++ +S D T K + C +PG+P+
Sbjct: 1333 VESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQ 1392
Query: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVP-GHPSQWTSQPPLC 714
NG ++ ++AG+S F C G+ L G I+CV + W PP C
Sbjct: 1393 NGSRS--GDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTC 1441
Score = 167 bits (423), Expect = 4e-41
Identities = 156/648 (24%), Positives = 253/648 (39%), Gaps = 96/648 (14%)
Query: 145 GPEGGEEETTTTIITTTTVTTTVTSPAYLL-------------------------SCGFP 179
G + G+++T I+T T+V + S + + SCG P
Sbjct: 465 GGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDP 524
Query: 180 PRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTI 239
PA+G + H G T F C ++L G++ + C + W+ + P C+ SC
Sbjct: 525 GIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQ--WSAKKPGCVFSCFFNF 582
Query: 240 HNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPL 299
+ + G ++SP G +L C W+I A R+HL F + ++ D L+++ G +
Sbjct: 583 TSPS-GVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDGATAE 641
Query: 300 SPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGN 359
+PV+ + +P + S +E ++ ++ F F + C P +
Sbjct: 642 APVLGTFSGNQLPS-SITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNECPDPGVPVNG 700
Query: 360 VTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSE 419
D + G+ +F C G+ L G + WN C+A CGG L+
Sbjct: 701 KRFGD-SLQLGSSISFLCDEGF-LGTQGSETITCVLKEGSVVWNSAVLRCEAPCGGHLTS 758
Query: 420 PAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDGDGPSARV 478
P+G +LSP WP Y C W + Q I + + D L + DG SA +
Sbjct: 759 PSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYDTLEVRDGRTYSAPL 818
Query: 479 LAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP-RNDTCPELPPPE 537
+ G Q + L+S+ L L F + GF L ++ + ++D C + P
Sbjct: 819 IGVYHGTQVPQFLISTSNYLYLLFSTDKSHSD----IGFQLRYETITLQSDHCLDPGIPV 874
Query: 538 WGWRTASHG-DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM------- 589
G R HG D G ++T+ C+ GY L + L C+ + WS A P+C+ +
Sbjct: 875 NGQR---HGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEALCGGFIQGS 931
Query: 590 --TCADPG---------------EIANG-------HRTASDAGFPV------GSHVQ-YR 618
T PG E ++G H ++G GS Q R
Sbjct: 932 SGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITENGSFTQPLR 991
Query: 619 CLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYE------------PCLNPGVPENG 666
L G L Y T ++ + ++ YE PC P VP
Sbjct: 992 QLTGSRLPAPISAGLYGNFTAQVRF---ISDFSMSYEGFNITFSEYDLEPCEEPEVP--A 1046
Query: 667 YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 714
Y + G++L F C+ G+ L G ITC+ G W+S P C
Sbjct: 1047 YSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRC 1094
Score = 158 bits (400), Expect = 2e-38
Identities = 156/639 (24%), Positives = 233/639 (36%), Gaps = 118/639 (18%)
Query: 176 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN--GTRPSWNGETPSCMA 233
C P P +G +D G F C+SGY LQG + CL G WN P+C+
Sbjct: 1735 CSSVPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVV 1794
Query: 234 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 293
CGG + G I+SP +L C W I EG + + +++ D L V
Sbjct: 1795 PCGGNLTERR-GTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVF 1853
Query: 294 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 353
G ++ VP L S + LY+ S+ + L ++ C P
Sbjct: 1854 DGADNTVTMLGSFSGTTVPAL-LNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEP 1912
Query: 354 FLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMC 413
+ V T + Y + +F C PGYAL+ I C+ T WN P C A C
Sbjct: 1913 AVPSNGVKTGE-RYLVNDVVSFQCEPGYALQGHAH---ISCMPGTVRRWNYPPPLCIAQC 1968
Query: 414 GGELSEPAGVVLSPDWPQSYSPGQDCVW--------GVHVQEEKRILLQVEILNVREGDM 465
GG + E GV+LSP +P +Y DC W G H+Q + D
Sbjct: 1969 GGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQ-------FLNFSTEPNHDY 2021
Query: 466 LTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLG----------- 514
+ + +G ++R++ + G + LLS+ + T+ F + PG
Sbjct: 2022 IEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQ 2081
Query: 515 -----QGFVLHFKEVPRNDTCP--------------------ELPPPEWGWRTASHGDLI 549
+GF L E+ R ++ P E P PE G
Sbjct: 2082 ISSFLRGFDL--SELERTNSTPPVAASYVWDLDPGCEAYELQECPDPEPFANGIVRGAGY 2139
Query: 550 R-GTVLTYQCEPGYELLGSDILTCQ--WDLSWSAAPPACQKIMTCADPGEIANGHRTASD 606
G +T++C PGY+L G +LTCQ + +W P C+ + C G I + + T
Sbjct: 2140 NVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCE--VPCG--GNITSSNGTVYS 2195
Query: 607 AGFPVGSHVQYRCL--------PGYSLEGAAMLTCYSRDTGTPKW---SDRVPKCALKYE 655
GFP C+ G L + + T S D T W P+ +
Sbjct: 2196 PGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFIT-IWDGPQQTAPRLGVFTR 2254
Query: 656 PCLNPGVPENGYQTLYKHH--------------------------------------YQA 677
V + Q L K H +
Sbjct: 2255 SMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNI 2314
Query: 678 GESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV 716
G+ +R+ C GF L+G +TC G Q+ PP+C+V
Sbjct: 2315 GDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEV 2353
Score = 157 bits (398), Expect = 3e-38
Identities = 139/558 (24%), Positives = 225/558 (40%), Gaps = 36/558 (6%)
Query: 173 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232
L C P A+G V + G + TF C GYQL G L C +GT +W+ P C
Sbjct: 2120 LQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCE 2179
Query: 233 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMV 292
CGG I ++ G + SP + C W+I G + L+ + + D + +
Sbjct: 2180 VPCGGNITSSN-GTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITI 2238
Query: 293 RSGGSPLSP--VIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC 350
G +P ++ M + + + + + A + ++ F A+ +C
Sbjct: 2239 WDGPQQTAPRLGVFTRSM----AKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKC 2294
Query: 351 FAP-FLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPAC 409
P L + V T + E+ G + + CLPG+ L + C T + P C
Sbjct: 2295 PPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLV---GNEILTCKLGTYLQFEGPPPIC 2351
Query: 410 KAMCGGE--LSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVE-ILNVREGDML 466
+ C L++ GV+LS +P SY Q C W V V+ + I L VE L+ ++ D
Sbjct: 2352 EVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEF 2411
Query: 467 TLFDGDGPSARVLAQLRGPQPRRRLL-SSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP 525
+FDG + +L L G ++ SS + L++ + G + + +P
Sbjct: 2412 EIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYCSLP 2471
Query: 526 RNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAA 581
R P G+ G++ + C GY L+G + C Q WS A
Sbjct: 2472 R--------APLHGFILGQTSTQPGGSI-HFGCNAGYRLVGHSMAICTRHPQGYHLWSEA 2522
Query: 582 PPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTP 641
P CQ ++C P NG + + VG+ Y C GY L+ A T DTG
Sbjct: 2523 IPLCQ-ALSCGLPEAPKNGMVFGKE--YTVGTKAMYSCSEGYHLQAGAEATAECLDTGL- 2578
Query: 642 KWSDR--VPKCALKYEPCLNPGVPENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTIT 698
WS+R P+C P ++ E+G ++ +++ YQ L C G+ G+ I
Sbjct: 2579 -WSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIR 2637
Query: 699 CVPGHPSQWTSQPPLCKV 716
C P C++
Sbjct: 2638 CQANGKWSLGDSTPTCRI 2655
Score = 137 bits (346), Expect = 3e-32
Identities = 166/709 (23%), Positives = 262/709 (36%), Gaps = 105/709 (14%)
Query: 161 TTVTTTVTSPAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL--N 218
T+V T V C P P G +D G + F C+ GY LQG + + C+ +
Sbjct: 328 TSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVS 387
Query: 219 GTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAE-GRRLHLH 277
+W+ P C A G I SP N C W+I A + + L
Sbjct: 388 DMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLA 447
Query: 278 FERVSLDEDNDRLMVRSGG--SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANP 335
FE L+ D L V GG V+Y VP+ ++S +++ ++ +
Sbjct: 448 FEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPDL-IVSTNHQMWLLFQTDGSGSS 506
Query: 336 LLLSLRFEAFEEDRCFAPFL-AHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIEC 394
L +E E+ C P + A+G + G F C P + L AI C
Sbjct: 507 LGFKASYEEIEQGSCGDPGIPAYGR--REGSRFHHGDTLKFECQPAFELV---GQKAITC 561
Query: 395 VDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQ 454
+ W+ +P C C + P+GVVLSP++P+ Y CVW + + E RI L
Sbjct: 562 QKNNQ--WSAKKPGCVFSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLA 619
Query: 455 VEILNVR-EGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGL 513
++V + D L + DG A VL G Q + SSG L+FQ G
Sbjct: 620 FNDIDVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGF 679
Query: 514 GQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIR-GTVLTYQCEPGY-ELLGSDILT 571
F R++ CP+ P G R GD ++ G+ +++ C+ G+ GS+ +T
Sbjct: 680 NITFTTF-----RHNECPDPGVPVNGKR---FGDSLQLGSSISFLCDEGFLGTQGSETIT 731
Query: 572 C---QWDLSWSAAPPACQKIMTCADP--GEIANGHRTASDAGFPVGSHVQYRCL------ 620
C + + W++A ++ C P G + + T G+P C
Sbjct: 732 CVLKEGSVVWNSA------VLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQ 785
Query: 621 PGYSLE-----------------------GAAMLTCYSRDTGTPKW-------------- 643
PGY ++ A ++ Y T P++
Sbjct: 786 PGYPIKITFDRFKTEVNYDTLEVRDGRTYSAPLIGVY-HGTQVPQFLISTSNYLYLLFST 844
Query: 644 ----SD-----RVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGE 694
SD R L+ + CL+PG+P NG + + + + G + F C G+ L
Sbjct: 845 DKSHSDIGFQLRYETITLQSDHCLDPGIPVNGQR--HGNDFYVGALVTFSCDSGYTLSDG 902
Query: 695 VTITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGL 754
+ C P QW+ P C+ + + P NL ++
Sbjct: 903 EPLECEPNF--QWSRALPSCEALCGGFIQGSSGTILSPGFP--DFYPNNLNCTWIIETS- 957
Query: 755 VIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYEAGDTR 803
G GV+ + F H Y IT F+ PL + +R
Sbjct: 958 ---HGKGVFFTF------HTFHLESGHDYLLITENGSFTQPLRQLTGSR 997
Score = 132 bits (331), Expect = 2e-30
Identities = 128/455 (28%), Positives = 196/455 (43%), Gaps = 62/455 (13%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPS--WNGETPSCM 232
+CG P R +G + + G + C+ G+ L+G L C G+ S W+ PSC
Sbjct: 138 TCGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCR 197
Query: 233 A--SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290
A +CGGT+ + G I SP N C W I A G + L F L++ D L
Sbjct: 198 ADDACGGTLRGQS-GIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGYDFL 256
Query: 291 MVR---------SGGSPLSPVI---------YDSDMDDVPERGLISDAQ-SLYVELLSET 331
V +G S +PVI + SD + +RG + Q +EL S
Sbjct: 257 EVTGTEGSSLWFTGASLPAPVISSKNWLRLHFTSD-GNHRQRGFSAQYQVKKQIELKSR- 314
Query: 332 PANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDP-----------EYRPGALATFSCLPG 380
L+ + + + ++ G+ DP ++R G+ F+C G
Sbjct: 315 --GVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEG 372
Query: 381 YALEPPGPPNAIECVDPTE--PHWNDTEPACKA-MCGGELSEPAGVVLSPDWPQSYSPGQ 437
Y L+ I C+ ++ W+D P C+A MC L P+G++ SP++P Y
Sbjct: 373 YDLQ---GSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNNA 429
Query: 438 DCVWGV-HVQEEKRILLQVEILNVREG-DMLTLFDG--DGPSARVLAQLRGPQPRRRLLS 493
CVW + + K I L E ++ G D LT+ DG DG VL L G ++S
Sbjct: 430 HCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPDLIVS 489
Query: 494 SGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTAS---HGDLIR 550
+ + L FQ G GF ++E+ + +C + P +G R S HGD
Sbjct: 490 TNHQMWLLFQT----DGSGSSLGFKASYEEIEQG-SCGDPGIPAYGRREGSRFHHGD--- 541
Query: 551 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 585
L ++C+P +EL+G +TCQ + WSA P C
Sbjct: 542 --TLKFECQPAFELVGQKAITCQKNNQWSAKKPGC 574
Score = 118 bits (295), Expect = 3e-26
Identities = 151/581 (25%), Positives = 212/581 (36%), Gaps = 79/581 (13%)
Query: 168 TSPAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNG 226
T ++SCG P P +G T G TA F C+SGY L G C+ NG W+G
Sbjct: 2650 TPTCRIISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGL---WSG 2706
Query: 227 ETPSCMASCGGTIHNATLGRIVSPEP---GGAVGPNLTCRW--VIEAAEGRRLHLHFERV 281
C+A GT PEP G G N + R V + G RL R+
Sbjct: 2707 SEVRCLAGHCGT-----------PEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRI 2755
Query: 282 SLDEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLR 341
+ + SG +P ++ P + D+ ++ + L+
Sbjct: 2756 CQQDHH-----WSGKTPFCVLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNS 2810
Query: 342 FEAFEEDRCFAPFLAHGNVTTT----DP-----------EYRPGALATFSCLPGYALEPP 386
D + L H + T+ DP + PG + FSC G+ L
Sbjct: 2811 TRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLR-- 2868
Query: 387 GPPNAIECVDPTEPHWNDTEPACKAMCGGELSEP--AGVVLSPDWPQSYSPGQDCVWGVH 444
+ E W+ ++P C + G P A VV S S S +C G +
Sbjct: 2869 ---GSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYY 2925
Query: 445 VQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDL----TL 500
L R + + G P V+ P L G D T+
Sbjct: 2926 ATG----------LLSRHCSVNGTWTGSDPECLVI-NCGDPGIPANGLRLGNDFRYNKTV 2974
Query: 501 QFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPEL------PPPEWGWRTASHGDLIRGTVL 554
+Q PG + K+ N T P PPP D + G+ +
Sbjct: 2975 TYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGSSV 3034
Query: 555 TYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSH 614
TY C GY+L + TC+ + SW+ P C + C DPG + G R D GF S
Sbjct: 3035 TYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVF-CGDPGVPSRGRR--EDRGFSYRSS 3091
Query: 615 VQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCA-LKYEPCLNPGVPENGYQTLYKH 673
V + C P L G+ C S T WS P C C +PGVP+ G Q
Sbjct: 3092 VSFSCHPPLVLVGSPRRFCQSDGT----WSGTQPSCIDPTLTTCADPGVPQFGIQN-NSQ 3146
Query: 674 HYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 714
YQ G ++ F C +G+ L G T TC+P W+ PP C
Sbjct: 3147 GYQVGSTVLFRCQKGYLLQGSTTRTCLPN--LTWSGTPPDC 3185
Score = 102 bits (253), Expect = 2e-21
Identities = 139/573 (24%), Positives = 200/573 (34%), Gaps = 129/573 (22%)
Query: 173 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232
L+SCG P P H +S G + C L G T +C G W G P C
Sbjct: 2771 LVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMC--GLDGHWTGSLPHCS 2828
Query: 233 ASCGGTI-------HNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDE 285
+ G H LG S +PG + + V+ + R +
Sbjct: 2829 GTSVGVCGDPGIPAHGIRLGD--SFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQP 2886
Query: 286 DNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY--------VELLSE------- 330
+ + + G+P + + SD GL+ + +Y LLS
Sbjct: 2887 ECGVISCGNPGTPSNARVVFSD-------GLVFSSSIVYECREGYYATGLLSRHCSVNGT 2939
Query: 331 -TPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPP 389
T ++P L + C P + N ++R T+ C+PGY +E
Sbjct: 2940 WTGSDPECLVIN--------CGDPGIP-ANGLRLGNDFRYNKTVTYQCVPGYMMESHRV- 2989
Query: 390 NAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEK 449
+ + C + WN T+P CKA+ + +P ++ P G D +WG V
Sbjct: 2990 SVLSCTK--DRTWNGTKPVCKAL----MCKPPPLI-----PNGKVVGSDFMWGSSVTYA- 3037
Query: 450 RILLQVEILNVREGDMLTL-----FDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQA 504
EG L+L +G+G L P F
Sbjct: 3038 ----------CLEGYQLSLPAVFTCEGNGSWTGEL----------------PQCFPVFCG 3071
Query: 505 PPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYEL 564
PG P+ G R G R +V ++ C P L
Sbjct: 3072 DPGVPSRG----------------------------RREDRGFSYRSSV-SFSCHPPLVL 3102
Query: 565 LGSDILTCQWDLSWSAAPPAC--QKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPG 622
+GS CQ D +WS P+C + TCADPG G + S G+ VGS V +RC G
Sbjct: 3103 VGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQ-GYQVGSTVLFRCQKG 3161
Query: 623 YSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLR 682
Y L+G+ TC T WS P C + C P P + G +L
Sbjct: 3162 YLLQGSTTRTCLPNLT----WSGTPPDCVPHH--CRQPETPTHANVGALDLP-SMGYTLI 3214
Query: 683 FFCYEGFELIG-EVTITCVPGHPSQWTSQPPLC 714
+ C EGF L G TC WT +PP+C
Sbjct: 3215 YSCQEGFSLKGGSEHRTCKAD--GSWTGKPPIC 3245
Score = 75.9 bits (185), Expect = 1e-13
Identities = 47/165 (28%), Positives = 74/165 (44%), Gaps = 10/165 (6%)
Query: 551 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 610
GTV+ + CE G+ L GS TCQ + SWS + P C +++C +PG +N SD G
Sbjct: 2854 GTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPEC-GVISCGNPGTPSNARVVFSD-GLV 2911
Query: 611 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTL 670
S + Y C GY G C T W+ P+C + C +PG+P NG +
Sbjct: 2912 FSSSIVYECREGYYATGLLSRHCSVNGT----WTGSDPECLV--INCGDPGIPANGLR-- 2963
Query: 671 YKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 715
+ ++ +++ + C G+ + W P+CK
Sbjct: 2964 LGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCK 3008
Score = 75.5 bits (184), Expect = 2e-13
Identities = 95/378 (25%), Positives = 142/378 (37%), Gaps = 53/378 (14%)
Query: 252 PGGAVG-PNLT-CRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMD 309
PG G PN C W I A E R+ L F+ +L+ED D L V G P P + +
Sbjct: 40 PGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEEDFDVLSVFDG--PPQPENLRTRLT 97
Query: 310 DVP-ERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYR 368
++S A +L + L+S+ + +E C P + +
Sbjct: 98 GFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEVLPSHTCGNPGRLPNGIQQGST-FN 156
Query: 369 PGALATFSCLPGYALEPPGPPNAIECVDPTEPH--WNDTEPACKA--MCGGELSEPAGVV 424
G +SC G+ LE + C +E W+ P+C+A CGG L +G++
Sbjct: 157 LGDKVRYSCNLGFFLEGHA---VLTCHAGSENSATWDFPLPSCRADDACGGTLRGQSGII 213
Query: 425 LSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDGDGPSARVL-AQL 482
SP +P Y DC W + + I L + +G D L + +G S A L
Sbjct: 214 SSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGYDFLEVTGTEGSSLWFTGASL 273
Query: 483 RGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLH---------FKEVPRNDT---- 529
P ++SS L L F + G + + K +P D
Sbjct: 274 PAP-----VISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIELKSRGVKLMPSKDNSQKT 328
Query: 530 --------------CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC--- 572
CP+ PE G R S D G+ + + C GY+L GS +TC
Sbjct: 329 SVLTQVGVSQGHNMCPDPGIPERGKRLGS--DFRLGSSVQFTCNEGYDLQGSKRITCMKV 386
Query: 573 -QWDLSWSAAPPACQKIM 589
+WS P C+ M
Sbjct: 387 SDMFAAWSDHRPVCRARM 404
Score = 73.2 bits (178), Expect = 9e-13
Identities = 50/168 (29%), Positives = 75/168 (44%), Gaps = 13/168 (7%)
Query: 550 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF 609
RG+V+ YQC G+ L+G + CQ D WS P C +++C PG + H S +
Sbjct: 2735 RGSVV-YQCNAGFRLIGMSVRICQQDHHWSGKTPFC-VLVSCGHPG--SPPHSQMSGDSY 2790
Query: 610 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCA-LKYEPCLNPGVPENGYQ 668
VG+ V+Y C+ +L G + C W+ +P C+ C +PG+P +G +
Sbjct: 2791 TVGAVVRYSCIGKRTLVGNSTRMCGL----DGHWTGSLPHCSGTSVGVCGDPGIPAHGIR 2846
Query: 669 TLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV 716
+ G +RF C G L G TC W+ P C V
Sbjct: 2847 --LGDSFDPGTVMRFSCEAGHVLRGSSERTCQAN--GSWSGSQPECGV 2890
Score = 60.8 bits (146), Expect = 5e-09
Identities = 57/215 (26%), Positives = 89/215 (41%), Gaps = 20/215 (9%)
Query: 413 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDG 471
C +L P G V SP +P Y +C W + +E+ RI L + + E D+L++FDG
Sbjct: 26 CTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEEDFDVLSVFDG 85
Query: 472 DGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC- 530
+ +L G Q ++S+ L+L+ + QGF ++ +P + TC
Sbjct: 86 PPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVS----AQGFHATYEVLP-SHTCG 140
Query: 531 --PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPA 584
LP T + GD +R Y C G+ L G +LTC + +W P+
Sbjct: 141 NPGRLPNGIQQGSTFNLGDKVR-----YSCNLGFFLEGHAVLTCHAGSENSATWDFPLPS 195
Query: 585 CQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRC 619
C+ C G + S FP H C
Sbjct: 196 CRADDACG--GTLRGQSGIISSPHFPSEYHNNADC 228
Score = 44.7 bits (104), Expect = 4e-04
Identities = 39/134 (29%), Positives = 54/134 (40%), Gaps = 6/134 (4%)
Query: 662 VPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQWTSQPPLCKVAYE 719
VPE Y + G +RF C G+ L G I C VPG +QW P C V
Sbjct: 1738 VPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCG 1797
Query: 720 ELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSG 779
L R+ + P L N I++P G I + V + T+ SL F G
Sbjct: 1798 GNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQI--QVVSFVTEQNWDSLEVFDG 1855
Query: 780 SHSYSPITVESDFS 793
+ + +T+ FS
Sbjct: 1856 AD--NTVTMLGSFS 1867
Score = 44.3 bits (103), Expect = 5e-04
Identities = 39/175 (22%), Positives = 70/175 (40%), Gaps = 9/175 (5%)
Query: 543 ASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHR 602
A GD I + +Q E GY+ L ++ + W +++ + + H
Sbjct: 234 AELGDTIALVFIDFQLEDGYDFL--EVTGTEGSSLWFTGASLPAPVISSKNWLRL---HF 288
Query: 603 TASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGV 662
T+ G QY+ L+ + S+D + + C +PG+
Sbjct: 289 TSDGNHRQRGFSAQYQVKKQIELKSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGI 348
Query: 663 PENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQWTSQPPLCK 715
PE G + ++ G S++F C EG++L G ITC V + W+ P+C+
Sbjct: 349 PERGKRL--GSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCR 401
Score = 38.5 bits (88), Expect = 0.025
Identities = 22/71 (30%), Positives = 31/71 (43%), Gaps = 1/71 (1%)
Query: 164 TTTVTSPAYL-LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRP 222
T T + P L ++CG P PA+G D T T+ C GY ++ +
Sbjct: 2939 TWTGSDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDR 2998
Query: 223 SWNGETPSCMA 233
+WNG P C A
Sbjct: 2999 TWNGTKPVCKA 3009
Score = 38.5 bits (88), Expect = 0.025
Identities = 30/90 (33%), Positives = 36/90 (40%), Gaps = 6/90 (6%)
Query: 150 EEETTTTIITTTTVTTTVTSPAY-LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQL 208
E + + T T T P L C PP +G V +D G + T+ C GYQL
Sbjct: 2985 ESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGSSVTYACLEGYQL 3044
Query: 209 QGEETLICL-NGTRPSWNGETPSCM-ASCG 236
C NG SW GE P C CG
Sbjct: 3045 SLPAVFTCEGNG---SWTGELPQCFPVFCG 3071
Score = 32.0 bits (71), Expect = 2.4
Identities = 17/56 (30%), Positives = 31/56 (55%), Gaps = 2/56 (3%)
Query: 743 NLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYE 798
++A AIL+P +I+ G +Y+Y + + K F+G + V + F NP+Y+
Sbjct: 3410 SVAAAILVPFIALIIAGFVLYLYKHRRRPK--VPFNGYAGHENTNVRATFENPMYD 3463
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 192 bits (487), Expect = 1e-48
Identities = 168/681 (24%), Positives = 278/681 (40%), Gaps = 87/681 (12%)
Query: 169 SPAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGE 227
S + +C P P +G + PG T F CD GY+LQGEE + C+ R W
Sbjct: 1417 SSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPS 1476
Query: 228 TPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN 287
P C+A CGG + ++ G I+SP + C W I + L F S++ +
Sbjct: 1477 PPVCIAPCGGNLTGSS-GFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNY 1535
Query: 288 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEE 347
D L + G SP+I +PER + S + ++++ S+ + L ++A
Sbjct: 1536 DFLYIYDGPDSNSPLIGSFQDSKLPER-IESSSNTMHLAFRSDGSVSYTGFHLEYKAKLR 1594
Query: 348 DRCFAPFLAHGNV---TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHW 402
+ CF P GN+ T +Y+ G+ T+ C GY L+ + + C+ D P W
Sbjct: 1595 ESCFDP----GNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGY---STLTCIMGDDGRPGW 1647
Query: 403 NDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE 462
N P+C A CG + G VLSP++P++YS G +CV+ + V +E + Q
Sbjct: 1648 NRALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL 1707
Query: 463 GDMLTLFDGDGPSARVLAQLRGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHF 521
D++ ++DG + +L+ L G L LSSG +T++F + P +GF +
Sbjct: 1708 HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTS----VGPITAKGFHFVY 1763
Query: 522 KEVPRNDT--CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC------- 572
+ VPR + C +P P +G R + + G+ + + C PGY L GS + C
Sbjct: 1764 QAVPRTSSTQCSSVPEPRFGRRIGN--EFAVGSSVLFDCNPGYILHGSIAIRCETVPNSL 1821
Query: 573 -QWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF--------PVGSHVQYRCLPGY 623
QW+ S C I+T ++ G+ D P G+ +Q + + +
Sbjct: 1822 AQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVV-SF 1880
Query: 624 SLE--------------GAAMLTCYS--------------------RDTGTPKWSDRVPK 649
+ E A L YS D +
Sbjct: 1881 ATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEY 1940
Query: 650 CALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTS 709
A+ + C P P +G + Y G+ + F C +G+ L G ITC+PG +W
Sbjct: 1941 TAIGLDSCPEPQTPSSGIK--IGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNY 1998
Query: 710 QPPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKL 769
P+C + + + P + I LP+G GV++ +
Sbjct: 1999 PIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGF------GVHLQFVNF 2052
Query: 770 QGKSLFGF----SGSHSYSPI 786
+++ + SGS S +
Sbjct: 2053 STETIHDYLEVRSGSSETSTV 2073
Score = 180 bits (456), Expect = 5e-45
Identities = 157/595 (26%), Positives = 249/595 (41%), Gaps = 74/595 (12%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMAS 234
SC P P HG D G T +F CDSGY+L EE L+C W+ P+C A
Sbjct: 905 SCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHW--WSHPLPTCDAL 962
Query: 235 CGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRS 294
CGG + + G I+SP +L C W ++ G+ + +F L++ +D L++
Sbjct: 963 CGGDVRGPS-GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITE 1021
Query: 295 GGSPLSPV--IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFA 352
GS P+ + SD+ GL + ++ + +S+ + ++ F + + C
Sbjct: 1022 NGSFTQPLARLTGSDLPPTINAGLYGNFRA-QLRFISDFSISYEGFNITFSEYNLEPCED 1080
Query: 353 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM 412
P + + + G TFSC GY LE + I C+ W+ P C A
Sbjct: 1081 PGIPQYG-SRIGFNFGIGDTLTFSCSSGYRLEGT---SEIICLGGGRRVWSAPLPRCVAE 1136
Query: 413 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGD 472
CG + G++LSP++P +Y +C++ + VQ K I + ++ +GD+L ++DG
Sbjct: 1137 CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGK 1196
Query: 473 GPSARVLAQLRGPQPRRRLLSS-GPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 531
+ +L G R LSS L L+F + G +GF L + + C
Sbjct: 1197 DKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNS----DTEGTDEGFQLVYTSFELSH-CE 1251
Query: 532 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQKIM 589
+ P++G++ + G G+ + Y C PGY L GS +L C +W P+C I
Sbjct: 1252 DPGIPQFGYKISDQGH-FAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC--IA 1308
Query: 590 TCADPGEIANGHRTASDAGFPVGSHVQYRCL------PG--YSLEGAAMLTCYSRDT--- 638
C + + R S G+P RC+ PG SL+ A T S D
Sbjct: 1309 ECGGRFKGESSGRILS-PGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRV 1367
Query: 639 -GTPKWSDRVPK--------------------------------CALKYE-----PCLNP 660
P +D + K A+++ C +P
Sbjct: 1368 WDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDP 1427
Query: 661 GVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ-WTSQPPLC 714
GVP NG T + G+++ F C G+EL GE ITC+ W PP+C
Sbjct: 1428 GVPMNG--TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1480
Score = 175 bits (443), Expect = 2e-43
Identities = 152/555 (27%), Positives = 234/555 (42%), Gaps = 36/555 (6%)
Query: 171 AYLLSCGFPPRP-AHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETP 229
AY L PRP +G V D G T +F C GY L G L CL+G +WN P
Sbjct: 2114 AYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLP 2173
Query: 230 SCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDR 289
C A CGG I A G I SP C W++ G ++++F + + D
Sbjct: 2174 RCEALCGGNI-TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDF 2232
Query: 290 LMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 349
+ V G SP I + E + S + + ++ S+ + + L + A++
Sbjct: 2233 ITVWDGPDQNSPQIGQFSGNTALE-SVYSTSNQILIKFHSDFTTSGFFV-LSYHAYQLRV 2290
Query: 350 CF-APFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAI-ECVDPTEPHWNDTEP 407
C P + + + T D E+ G + + CLPG+ L NAI C + P
Sbjct: 2291 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTL----VGNAILTCRLGERLQMDGAPP 2346
Query: 408 ACKAMC-GGELS-EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNV-REGD 464
C+ +C EL + GV+LSP +P SY Q C W + V++ I + VE +E D
Sbjct: 2347 VCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFD 2406
Query: 465 MLTLFDGDGPSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKE 523
+L ++DG + VL L G + S+G ++ LQ+ A G G ++ +
Sbjct: 2407 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCS 2466
Query: 524 VPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDL----SWS 579
P + PP + + G L +V+ + C+ G+ L+G C+ +W
Sbjct: 2467 TPES-------PPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWD 2517
Query: 580 AAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTG 639
A PACQ I +C P NG +D + VG+ V Y C GY L + T + G
Sbjct: 2518 APVPACQAI-SCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDG 2574
Query: 640 TPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC 699
T ++ P+C + C P NG + + Y G + F C GF L+G C
Sbjct: 2575 TWSNHNKTPRCVV--ISCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVREC 2630
Query: 700 VPGHPSQWTSQPPLC 714
+ W+ C
Sbjct: 2631 LSS--GLWSESETRC 2643
Score = 174 bits (440), Expect = 4e-43
Identities = 152/596 (25%), Positives = 233/596 (39%), Gaps = 73/596 (12%)
Query: 175 SCGFPPRPAHGDVSVTDLHP-GGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMA 233
SC P P+ G + + D + G +F CD GY LQG + C+ G WN P C+A
Sbjct: 1947 SCPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLA 2005
Query: 234 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 293
CGG + + + G I+SP G +L C W I G +HL F S + +D L VR
Sbjct: 2006 QCGGAMSDFS-GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVR 2064
Query: 294 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 353
SG S S VI +P L S + S+ N + ++A++ C P
Sbjct: 2065 SGSSETSTVIGRLSGPQIPS-SLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDP 2123
Query: 354 F-LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM 412
+G V D + G +F C PGY L +A+ C+ +WN P C+A+
Sbjct: 2124 RPFRNGFVIGND--FTVGQTISFECFPGYTLIGN---SALTCLHGVSRNWNHPLPRCEAL 2178
Query: 413 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-GDMLTLFDG 471
CGG ++ G + SP +P Y QDC W V V I + +L D +T++DG
Sbjct: 2179 CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDG 2238
Query: 472 DGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 531
++ + Q G + S+ + ++F + GF + + C
Sbjct: 2239 PDQNSPQIGQFSGNTALESVYSTSNQILIKFH------SDFTTSGFFVLSYHAYQLRVCQ 2292
Query: 532 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQ--- 586
PP + G ++ YQC PG+ L+G+ ILTC+ L APP CQ
Sbjct: 2293 PPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLC 2352
Query: 587 -----------------------KIMTCADPGEIANGHRTA-------SDAGFPV----- 611
+ CA + G+ ++ F V
Sbjct: 2353 PANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYD 2412
Query: 612 GSHVQ----------YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPG 661
G ++Q Y + G + +S D G K R+ A C P
Sbjct: 2413 GPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY---CSTPE 2469
Query: 662 VPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS--QWTSQPPLCK 715
P +GY + + Q +R+ C GF L+G+ + C W + P C+
Sbjct: 2470 SPPHGY-IISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2524
Score = 161 bits (407), Expect = 3e-39
Identities = 145/598 (24%), Positives = 236/598 (39%), Gaps = 78/598 (13%)
Query: 176 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSCMA 233
C P P G + G + F C+ GY L G + C + + WN P+C+
Sbjct: 1774 CSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIV 1833
Query: 234 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 293
CGG + G I+SP NL C W I EG + + + + + D L
Sbjct: 1834 PCGGILTKRK-GTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFY 1892
Query: 294 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 353
GG +P + +P L S + +LY+ S+ + L + A D C P
Sbjct: 1893 DGGDNNAPRLGSYSGTTIPHL-LNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEP 1951
Query: 354 FLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMC 413
+ D Y G + +F C GY+L+ + I C+ WN P C A C
Sbjct: 1952 QTPSSGIKIGD-RYMVGDVVSFQCDQGYSLQ---GHSHITCMPGPVRRWNYPIPICLAQC 2007
Query: 414 GGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQ-VEILNVREGDMLTLFDGD 472
GG +S+ +GV+LSP +P +Y DC W +++ + LQ V D L + G
Sbjct: 2008 GGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGS 2067
Query: 473 GPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPE 532
++ V+ +L GPQ L S+ + +L F + QGF + + + + +CP+
Sbjct: 2068 SETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNK----QGFHIVY-QAYQLQSCPD 2122
Query: 533 LPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS--WSAAPPACQKIMT 590
P G+ + D G ++++C PGY L+G+ LTC +S W+ P C+ +
Sbjct: 2123 PRPFRNGFVIGN--DFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL-- 2178
Query: 591 CADPGEIANGHRTASDAGFP------------------VGSHVQYRCL---PGYSL---- 625
C G I + T G+P G ++ + L P Y
Sbjct: 2179 CG--GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVW 2236
Query: 626 ----EGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQ----- 676
+ + + +S +T + +K+ + +G+ L H YQ
Sbjct: 2237 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKF----HSDFTTSGFFVLSYHAYQLRVCQ 2292
Query: 677 ------------------AGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV 716
G+ +R+ C GF L+G +TC G Q PP+C+V
Sbjct: 2293 PPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQV 2350
Score = 155 bits (391), Expect = 2e-37
Identities = 115/438 (26%), Positives = 186/438 (42%), Gaps = 18/438 (4%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMAS 234
SCG P P +G F C G++L GE++++C + W+ P C+
Sbjct: 559 SCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ--WSANIPICIFP 616
Query: 235 CGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRS 294
C A +G ++SP+ G NL C W I + G R+HL F L+ D L V+
Sbjct: 617 CLSNF-TAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKD 675
Query: 295 GGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPF 354
G SP SP++ +VP L S++ L +E ++ + ++ + F + C P
Sbjct: 676 GDSPESPILGTFTGAEVPSH-LTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPG 734
Query: 355 LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCG 414
+ N ++ G+ + C G+ ++ G + + W+ P C A CG
Sbjct: 735 IPI-NARRFGDNFQLGSSISVICEEGF-IKTQGTETITCILMDGKVMWSGLIPKCGAPCG 792
Query: 415 GELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDG 473
G S P+GV+LSP WP Y +C W + + I + E D+L + DG
Sbjct: 793 GHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPN 852
Query: 474 PSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRND-TCPE 532
+ +L G Q + L SS + L F N GF +H++ V N +C +
Sbjct: 853 LLSPLLGSYNGTQVPQFLFSSSNFIYLLFTT----DNSRSNNGFKIHYESVTVNTYSCLD 908
Query: 533 LPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCA 592
P G R D G+ +++ C+ GY L + L C+ + WS P C + C
Sbjct: 909 PGIPVHGRRYGH--DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL--CG 964
Query: 593 DPGEIANGHRTASDAGFP 610
G++ T G+P
Sbjct: 965 --GDVRGPSGTILSPGYP 980
Score = 148 bits (373), Expect = 2e-35
Identities = 121/455 (26%), Positives = 188/455 (41%), Gaps = 23/455 (5%)
Query: 173 LLSCGFPPRPAHG-DVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 231
L C P P G +S G T + C+ GY L G L C+ G R +W+ PSC
Sbjct: 1247 LSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC 1306
Query: 232 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 291
+A CGG + GRI+SP NL C W+IE G + L F + +D L
Sbjct: 1307 IAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILR 1366
Query: 292 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 351
V G ++ + +PE G+ S + ++ ++ + +++F + C
Sbjct: 1367 VWDGPPENDMLLKEISGSLIPE-GIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACR 1425
Query: 352 APFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH-WNDTEPACK 410
P + N T PG F C PGY L+ I C+ + W + P C
Sbjct: 1426 DPGVPM-NGTRNGDGREPGDTVVFQCDPGYELQ---GEERITCIQVENRYFWQPSPPVCI 1481
Query: 411 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLF 469
A CGG L+ +G +LSP++P Y +DC W + V + I L ++ D L ++
Sbjct: 1482 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIY 1541
Query: 470 DGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT 529
DG ++ ++ + + R+ SS + L F++ GF L +K R ++
Sbjct: 1542 DGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSY----TGFHLEYKAKLR-ES 1596
Query: 530 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPAC 585
C P T D G+ +TY C+ GY L G LTC W+ A P+C
Sbjct: 1597 C--FDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1654
Query: 586 QKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCL 620
C + G T +P V + C+
Sbjct: 1655 H--APCGSRSTGSEG--TVLSPNYPKNYSVGHNCV 1685
Score = 145 bits (367), Expect = 1e-34
Identities = 164/663 (24%), Positives = 249/663 (37%), Gaps = 86/663 (12%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETPSCM 232
SC P +G D G T T++CD+GY LQG TL C+ G RP WN PSC
Sbjct: 1596 SCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH 1655
Query: 233 ASCGGTIHNATLGRIVSPE--PGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290
A CG + G ++SP +VG N + F + SL +D +
Sbjct: 1656 APCGSR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL---HDVV 1711
Query: 291 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAF---EE 347
V G + S ++ E +S + + S P ++A
Sbjct: 1712 EVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSS 1771
Query: 348 DRCFA-PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIEC--VDPTEPHWND 404
+C + P G E+ G+ F C PGY L AI C V + WND
Sbjct: 1772 TQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGYILHGS---IAIRCETVPNSLAQWND 1826
Query: 405 TEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQV-EILNVREG 463
+ P C CGG L++ G +LSP +P+ Y +CVW + V E I +QV
Sbjct: 1827 SLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNW 1886
Query: 464 DMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKE 523
D L +DG +A L G L S+ +L L FQ+ GF L +
Sbjct: 1887 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVS----AAGFHLEYTA 1942
Query: 524 VPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAA 581
+ D+CPE P G + + G V+++QC+ GY L G +TC W+
Sbjct: 1943 IGL-DSCPEPQTPSSGIKIGDR--YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYP 1999
Query: 582 PPACQK------------IMTCADPGEIANGHRTASDAGFPVGS--HVQYRCLPGYSLEG 627
P C I++ PG + P+G H+Q+ ++
Sbjct: 2000 IPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHD 2059
Query: 628 AAMLTCYSRDTGTP-------------------------------KWSDRVPKCALKYEP 656
+ S +T T K + A + +
Sbjct: 2060 YLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS 2119
Query: 657 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV 716
C +P NG+ + + + G+++ F C+ G+ LIG +TC+ G W P C
Sbjct: 2120 CPDPRPFRNGF--VIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRC-- 2175
Query: 717 AYEELLDNRKLEVTQTT--DPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSL 774
E L + T P E N L + + G+G+YI +T LQ + +
Sbjct: 2176 ---EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWL---VRVPPGNGIYINFTVLQTEPI 2229
Query: 775 FGF 777
+ F
Sbjct: 2230 YDF 2232
Score = 122 bits (307), Expect = 1e-27
Identities = 105/424 (24%), Positives = 179/424 (42%), Gaps = 32/424 (7%)
Query: 176 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSC-M 232
C P P +G +D G T F CD Y LQG +++ C + +W+ P C +
Sbjct: 382 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 441
Query: 233 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRR-LHLHFERVSLDEDNDRLM 291
+CG + + G SP N C WVI A + + ++FE L+ D L
Sbjct: 442 KTCGSNLQGPS-GTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 500
Query: 292 VRSGGSPLSP-----VIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFE 346
+ GG P V+ S + D+ ++S + +++ L ++ + + ++ E
Sbjct: 501 IGDGGEVGDPRTVLQVLTGSFVPDL----IVSMSSQMWLHLQTDESVGSVGFKVNYKEIE 556
Query: 347 EDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 406
++ C P + D + + F C G+ L +I C + + W+
Sbjct: 557 KESCGDPGTPLYGIREGD-GFSNRDVLRFECQFGFELI---GEKSIVCQENNQ--WSANI 610
Query: 407 PACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDM 465
P C C + P G VLSPD+P+ Y +C+W + RI L ++ + D
Sbjct: 611 PICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDF 670
Query: 466 LTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP 525
L + DGD P + +L G + L S+ L L+FQA + G+GF + +
Sbjct: 671 LAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQA----DHSMSGRGFNITYNTFG 726
Query: 526 RNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGY-ELLGSDILTC---QWDLSWSAA 581
N+ CP+ P R + L G+ ++ CE G+ + G++ +TC + WS
Sbjct: 727 HNE-CPDPGIPINARRFGDNFQL--GSSISVICEEGFIKTQGTETITCILMDGKVMWSGL 783
Query: 582 PPAC 585
P C
Sbjct: 784 IPKC 787
Score = 122 bits (306), Expect = 1e-27
Identities = 127/455 (27%), Positives = 190/455 (41%), Gaps = 62/455 (13%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETPSCM 232
SCG P P G + T G + C +GY L G L C+ + SW+ P C
Sbjct: 177 SCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 236
Query: 233 A--SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290
A +CGGT+ ++ G I SP N C W I A G + L F ++E D L
Sbjct: 237 AEDACGGTMRGSS-GIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYL 295
Query: 291 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFE---- 346
+ G P P I+ S M+ P +IS+ L + ++++ S ++ +
Sbjct: 296 EI-EGSEP--PTIWLSGMNIPPP--IISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDF 350
Query: 347 EDRCFAPF-----------LAHGNVTTT-----DP-----------EYRPGALATFSCLP 379
+ R F F L G + T DP ++ G+ FSC
Sbjct: 351 KSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDE 410
Query: 380 GYALEPPGPPNAIECVDPTE--PHWNDTEPACKA-MCGGELSEPAGVVLSPDWPQSYSPG 436
Y L+ +I C E W+D P CK CG L P+G SP++P Y
Sbjct: 411 DYVLQ---GAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSN 467
Query: 437 QDCVWGV-HVQEEKRILLQVEILNVREG-DMLTLFDGD--GPSARVLAQLRGPQPRRRLL 492
CVW + V K I + E ++ G D LT+ DG G VL L G ++
Sbjct: 468 AQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIV 527
Query: 493 SSGPDLTLQFQAPPGPPNPGLGQ-GFVLHFKEVPRNDTCPELPPPEWGWRTASHGD-LIR 550
S + L Q + +G GF +++KE+ + ++C + P +G R GD
Sbjct: 528 SMSSQMWLHLQT-----DESVGSVGFKVNYKEIEK-ESCGDPGTPLYGIR---EGDGFSN 578
Query: 551 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 585
VL ++C+ G+EL+G + CQ + WSA P C
Sbjct: 579 RDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 613
Score = 94.7 bits (234), Expect = 3e-19
Identities = 60/170 (35%), Positives = 83/170 (48%), Gaps = 15/170 (8%)
Query: 547 DLIRGTVLTYQCEPGY--ELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTA 604
D + G ++Y C+PGY EL GS I TC + +WS P C+ + TC P +I+NG
Sbjct: 3019 DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV-TCPTPPQISNGRLEG 3077
Query: 605 SDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 664
++ F G + Y C PGY L A+LTC G WS VP+C K+ C +PG+P
Sbjct: 3078 TN--FDWGFSISYICSPGYELSFPAVLTC----VGNGTWSGEVPQCLPKF--CGDPGIPA 3129
Query: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 714
G + YQ+ + F C F L+G T C W+ P C
Sbjct: 3130 QGKREGKSFIYQS--EVSFSCNFPFILVGSSTRICQA--DGTWSGSSPHC 3175
Score = 92.0 bits (227), Expect = 2e-18
Identities = 106/445 (23%), Positives = 163/445 (36%), Gaps = 75/445 (16%)
Query: 228 TPSCMA----SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSL 283
T SC+ +CGGT+ G I SP C WVI A E R+ + F+ +L
Sbjct: 54 TVSCVKGFIYTCGGTLKGLN-GTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFAL 112
Query: 284 DEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-VELLSETPANPLLLSLRF 342
+E+ D L + G P + + + ++ +S++ + L S+ + + +
Sbjct: 113 EEEYDYLSLYDGHP--HPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 170
Query: 343 EAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEP 400
E + C P + V + G +SC+ GY L+ G P + C+
Sbjct: 171 EELQSSSCGNPGVPPKGVLY-GTRFDVGDKIRYSCVTGYILD--GHPQ-LTCIANSVNTA 226
Query: 401 HWNDTEPACKA--MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEIL 458
W+ P C+A CGG + +G++ SP +P Y DC W + + I L
Sbjct: 227 SWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDF 286
Query: 459 NVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFV 518
+ E +G P L+ + P P ++S+ L L F G +
Sbjct: 287 QMEEKYDYLEIEGSEPPTIWLSGMNIPPP---IISNKNWLRLHFVTDSNHRYRGFSAPYQ 343
Query: 519 LH---------FKEVPRNDTCPELPP-PEWGWRTASHGDLIRGTVLTYQCEPGYELLGSD 568
+ FK P D + E G +TAS+
Sbjct: 344 VKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASN----------------------- 380
Query: 569 ILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGA 628
C DPGE NG R SD F +GS VQ+ C Y L+GA
Sbjct: 381 ---------------------LCPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGA 417
Query: 629 AMLTCYSRDTGTPKWSDRVPKCALK 653
+TC WSD P C +K
Sbjct: 418 KSITCQRIAEVFAAWSDHRPVCKVK 442
Score = 88.2 bits (217), Expect = 3e-17
Identities = 61/189 (32%), Positives = 87/189 (46%), Gaps = 16/189 (8%)
Query: 529 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 588
TC + P G R S+ + + Y C+ GY L GS+ TC + SW+ P C K
Sbjct: 2886 TCGDPGTPGHGSRQESN--FRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC-KA 2942
Query: 589 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 648
+ C +PG ANG D G S V Y C+ GY L G ++ C + T WS +P
Sbjct: 2943 VQCGNPGTTANGKVFRID-GTTFSSSVIYSCMEGYILSGPSVRQCTANGT----WSGTLP 2997
Query: 649 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGF--ELIGEVTITCVPGHPSQ 706
C + C +PG+P NG + Y Y G+++ + C G+ EL G TC
Sbjct: 2998 NCTI--ISCGDPGIPANGLR--YGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTIN--GT 3051
Query: 707 WTSQPPLCK 715
W+ P C+
Sbjct: 3052 WSGVMPTCR 3060
Score = 84.0 bits (206), Expect = 5e-16
Identities = 59/190 (31%), Positives = 81/190 (42%), Gaps = 12/190 (6%)
Query: 527 NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 586
N + P +P HG+ GTV+ Y C PGY L GS +L CQ + W P C
Sbjct: 2763 NCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2822
Query: 587 KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 646
I C PG N S + GS V Y C SL G + TC WS
Sbjct: 2823 MI-DCGHPGVPPNA--VLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG----HWSGS 2875
Query: 647 VPKCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS 705
P C+ C +PG P G+ + + +++ ++R+ C G+ L G TC+
Sbjct: 2876 QPHCSGDATGTCGDPGTP--GHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLAN--G 2931
Query: 706 QWTSQPPLCK 715
WT + P CK
Sbjct: 2932 SWTGRQPECK 2941
Score = 83.2 bits (204), Expect = 9e-16
Identities = 62/187 (33%), Positives = 82/187 (43%), Gaps = 13/187 (6%)
Query: 529 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 588
TCP P G ++ D G ++Y C PGYEL +LTC + +WS P C
Sbjct: 3063 TCPTPPQISNGRLEGTNFDW--GFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP- 3119
Query: 589 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 648
C DPG A G R F S V + C + L G++ C + T WS P
Sbjct: 3120 KFCGDPGIPAQGKREGK--SFIYQSEVSFSCNFPFILVGSSTRICQADGT----WSGSSP 3173
Query: 649 KCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 707
C + C NPGVP +G Q +Q G ++F C +G L G T TC+P W
Sbjct: 3174 HCIEPTQTSCENPGVPRHGSQN-NTFGFQVGSVVQFHCKKGHLLQGSTTRTCLP--DLTW 3230
Query: 708 TSQPPLC 714
+ P C
Sbjct: 3231 SGIQPEC 3237
Score = 82.4 bits (202), Expect = 2e-15
Identities = 53/167 (31%), Positives = 74/167 (44%), Gaps = 14/167 (8%)
Query: 550 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF 609
R TV+ YQC PG+ L+GS + CQ D +WS P+C + +C PG G S GF
Sbjct: 2667 RDTVV-YQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV-SCGHPGSPIYGR--TSGNGF 2722
Query: 610 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT 669
V + C GY ++G C + +WS P C K C +PG+P N +
Sbjct: 2723 NFNDVVTFSCNIGYLMQGPTKAQCQA----NRQWSHPPPMC--KVVNCSDPGIPANSKRE 2776
Query: 670 LYKHH--YQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 714
H + G + + C G+ L G + C P QW P C
Sbjct: 2777 SKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN--GQWDKPLPEC 2821
Score = 67.8 bits (164), Expect = 4e-11
Identities = 51/188 (27%), Positives = 80/188 (42%), Gaps = 15/188 (7%)
Query: 529 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 588
+C ELP P G + + G+ + C+ G+ L+GS + C WS + C
Sbjct: 2589 SCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLA- 2645
Query: 589 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 648
C P I NG + G+ V Y+C PG+ L G+++ C WS ++P
Sbjct: 2646 GHCGIPELIVNGQVIGENYGYR--DTVVYQCNPGFRLIGSSVRICQQDHN----WSGQLP 2699
Query: 649 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 708
C C +PG P G + + + + + F C G+ + G C QW+
Sbjct: 2700 SCVPV--SCGHPGSPIYGRTS--GNGFNFNDVVTFSCNIGYLMQGPTKAQCQANR--QWS 2753
Query: 709 SQPPLCKV 716
PP+CKV
Sbjct: 2754 HPPPMCKV 2761
Score = 52.0 bits (123), Expect = 2e-06
Identities = 40/130 (30%), Positives = 59/130 (45%), Gaps = 14/130 (10%)
Query: 525 PRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPA 584
P +C P G + + G + G+V+ + C+ G+ L GS TC DL+WS P
Sbjct: 3178 PTQTSCENPGVPRHGSQNNTFGFQV-GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPE 3236
Query: 585 CQKIMTCADPGEIANGHRTASDAGFPVGSH---VQYRCLPGYSLEGAA-MLTCYSRDTGT 640
C +C P A+ A+ G + SH + Y C PG+ L G C S +T
Sbjct: 3237 CIP-HSCKQPETPAH----ANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNT-- 3289
Query: 641 PKWSDRVPKC 650
W+ +VP C
Sbjct: 3290 --WTGKVPIC 3297
Score = 51.6 bits (122), Expect = 3e-06
Identities = 31/77 (40%), Positives = 37/77 (48%), Gaps = 7/77 (9%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMA 233
+CG P P HG ++ T + CD+GY L G E CL NG SW G P C A
Sbjct: 2886 TCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANG---SWTGRQPECKA 2942
Query: 234 -SCG--GTIHNATLGRI 247
CG GT N + RI
Sbjct: 2943 VQCGNPGTTANGKVFRI 2959
Score = 44.3 bits (103), Expect = 5e-04
Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 4/66 (6%)
Query: 652 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPG--HPSQWTS 709
L+ C NPGVP G LY + G+ +R+ C G+ L G +TC+ + + W
Sbjct: 173 LQSSSCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 230
Query: 710 QPPLCK 715
P+C+
Sbjct: 231 PVPICR 236
Score = 43.9 bits (102), Expect = 6e-04
Identities = 39/148 (26%), Positives = 56/148 (37%), Gaps = 14/148 (9%)
Query: 655 EPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ--WTSQPP 712
E C +PG NG T Y+ G ++ ++C G+ L G T+TC+ G + W P
Sbjct: 1595 ESCFDPGNIMNG--TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1652
Query: 713 LCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIV---------LGSGVY 763
C + V P G N +I +P V+ L V
Sbjct: 1653 SCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVE 1712
Query: 764 IYYTKLQGKSLF-GFSGSHSYSPITVES 790
+Y Q SL SGSHS + + S
Sbjct: 1713 VYDGPTQQSSLLSSLSGSHSGESLPLSS 1740
Score = 43.1 bits (100), Expect = 0.001
Identities = 30/99 (30%), Positives = 47/99 (47%), Gaps = 9/99 (9%)
Query: 140 PGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPPRPAHGDVSVTDLHPGGTAT 199
PG + G T T T + V T + ++C PP+ ++G + T+ G + +
Sbjct: 3032 PGYTMELNGSRIRTCTINGTWSGVMPTCRA----VTCPTPPQISNGRLEGTNFDWGFSIS 3087
Query: 200 FHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMAS-CG 236
+ C GY+L L C+ NGT W+GE P C+ CG
Sbjct: 3088 YICSPGYELSFPAVLTCVGNGT---WSGEVPQCLPKFCG 3123
Score = 41.6 bits (96), Expect = 0.003
Identities = 29/105 (27%), Positives = 43/105 (40%), Gaps = 4/105 (3%)
Query: 151 EETTTTIITT--TTVTTTVTSPAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQL 208
+E TT + + T T ++SCG P P +G+ T G TA F CD G+ L
Sbjct: 2563 KELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFML 2622
Query: 209 QGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPG 253
G CL+ W+ C+A G G+++ G
Sbjct: 2623 VGSAVRECLSS--GLWSESETRCLAGHCGIPELIVNGQVIGENYG 2665
Score = 41.2 bits (95), Expect = 0.004
Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 4/63 (6%)
Query: 652 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQP 711
++ E C +PG P G + + + LRF C GFELIGE +I C +QW++
Sbjct: 555 IEKESCGDPGTPLYGIRE--GDGFSNRDVLRFECQFGFELIGEKSIVCQEN--NQWSANI 610
Query: 712 PLC 714
P+C
Sbjct: 611 PIC 613
Score = 40.4 bits (93), Expect = 0.007
Identities = 22/59 (37%), Positives = 27/59 (45%), Gaps = 3/59 (5%)
Query: 175 SCGFPPRPAHGDVSVT-DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232
SC P P HG + T G FHC G+ LQG T CL +W+G P C+
Sbjct: 3182 SCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDL--TWSGIQPECI 3238
Score = 38.5 bits (88), Expect = 0.025
Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 4/62 (6%)
Query: 657 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQWTSQPPLC 714
C +PG PENG + + G +++F C E + L G +ITC + + W+ P+C
Sbjct: 382 CPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 439
Query: 715 KV 716
KV
Sbjct: 440 KV 441
Score = 38.5 bits (88), Expect = 0.025
Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 3/62 (4%)
Query: 176 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-AS 234
CG P +G V + T + C+ G++L G IC +W+G+ PSC+ S
Sbjct: 2648 CGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQD--HNWSGQLPSCVPVS 2705
Query: 235 CG 236
CG
Sbjct: 2706 CG 2707
Score = 38.5 bits (88), Expect = 0.025
Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 6/78 (7%)
Query: 173 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGY--QLQGEETLIC-LNGTRPSWNGETP 229
++SCG P PA+G D G ++ C GY +L G C +NGT W+G P
Sbjct: 3001 IISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMP 3057
Query: 230 SCMASCGGTIHNATLGRI 247
+C A T + GR+
Sbjct: 3058 TCRAVTCPTPPQISNGRL 3075
Score = 35.8 bits (81), Expect = 0.16
Identities = 18/58 (31%), Positives = 24/58 (41%), Gaps = 2/58 (3%)
Query: 174 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 231
+SCG P P +G S + TF C+ GY +QG C W+ P C
Sbjct: 2704 VSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQC--QANRQWSHPPPMC 2759
Score = 34.7 bits (78), Expect = 0.36
Identities = 20/67 (29%), Positives = 28/67 (41%), Gaps = 4/67 (5%)
Query: 173 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 231
++ CG P P + +S G T + C L G+ + C LNG W+G P C
Sbjct: 2823 MIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG---HWSGSQPHC 2879
Query: 232 MASCGGT 238
GT
Sbjct: 2880 SGDATGT 2886
Score = 34.3 bits (77), Expect = 0.48
Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 4/61 (6%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGG-TATFHCDSGYQLQ-GEETLICLNGTRPSWNGETPSCM 232
SC P PAH +V DL G T + C G+ L G E +C + +W G+ P C
Sbjct: 3241 SCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDN--TWTGKVPICE 3298
Query: 233 A 233
A
Sbjct: 3299 A 3299
Score = 34.3 bits (77), Expect = 0.48
Identities = 21/75 (28%), Positives = 40/75 (53%), Gaps = 5/75 (6%)
Query: 727 LEVTQTTDPSRQLEGGN---LALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSY 783
L +++ ++ S Q G N +A+AIL+P +I G G Y+Y + K+ ++G +
Sbjct: 3442 LNMSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKT--QYTGCSVH 3499
Query: 784 SPITVESDFSNPLYE 798
++ F NP+Y+
Sbjct: 3500 ENNNGQAAFENPMYD 3514
Score = 31.6 bits (70), Expect = 3.1
Identities = 15/52 (28%), Positives = 27/52 (51%), Gaps = 7/52 (13%)
Query: 542 TASHGDLI------RGTVLTYQCEPGYELLG-SDILTCQWDLSWSAAPPACQ 586
T +H +++ G L Y C+PG+ L G ++ C+ D +W+ P C+
Sbjct: 3247 TPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICE 3298
Score = 31.2 bits (69), Expect = 4.0
Identities = 28/80 (35%), Positives = 35/80 (43%), Gaps = 11/80 (13%)
Query: 173 LLSCGFPPRPAHGDVSVTDLHPG---GTATFH-CDSGYQLQGEETLICL-NGTRPSWNGE 227
+++C P PA+ H GT F+ C+ GY L G LIC NG W+
Sbjct: 2761 VVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNG---QWDKP 2817
Query: 228 TPSC-MASCG--GTIHNATL 244
P C M CG G NA L
Sbjct: 2818 LPECIMIDCGHPGVPPNAVL 2837
>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
Length = 2489
Score = 102 bits (255), Expect = 1e-21
Identities = 146/617 (23%), Positives = 225/617 (36%), Gaps = 120/617 (19%)
Query: 176 CGFPPRPAHGDVSVT---DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC- 231
C PP HG+ + + + PG + C+ GY L+G +L C + W+ E P C
Sbjct: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCT--PQGDWSPEAPRCA 1704
Query: 232 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRL------HLHF------- 278
+ SC + GR++ P + L + EG RL H
Sbjct: 1705 VKSCDDFLGQLPHGRVLFP-----LNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLW 1759
Query: 279 -------ERVSLDEDNDRLMVRSGGSPLSPVIYDSDM----DDVPERGL---------IS 318
E + L R G+P + Y ++ D P+RG+ I
Sbjct: 1760 NNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIR 1819
Query: 319 DAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCL 378
+ + +PA LS+R + F PF A + D E+ G + C
Sbjct: 1820 CTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQF-PF-ASPTIPINDFEFPVGTSLNYECR 1877
Query: 379 PGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSY----- 433
PGY G +I C++ W+ E C+ G EP ++ + +
Sbjct: 1878 PGYF----GKMFSISCLENLV--WSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVN 1931
Query: 434 -----------SPGQDC-VWGVHVQEEKRILLQVEILNVR-------------------E 462
SP C V G +V +K+ + EI++
Sbjct: 1932 YSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPI-CEIISCEPPPTISNGDFYSNNRTSFHN 1990
Query: 463 GDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFK 522
G ++T GP L +L G R + + D + + P P +
Sbjct: 1991 GTVVTYQCHTGPDGEQLFELVG---ERSIYCTSKDDQVGVWSSPPP-------------R 2034
Query: 523 EVPRND-TCPELPPPEWGWRTASHGDLIRGT-VLTYQCEPGYELLGSDILTCQWDLSWSA 580
+ N T PE+ E R + T ++ ++C+PG+ ++GS + CQ + W
Sbjct: 2035 CISTNKCTAPEV---ENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGP 2091
Query: 581 APPACQKIMTCADPGEIANGHRTAS-DAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTG 639
P C ++ C P EI +G T S F G V Y C P Y L GAA L C T
Sbjct: 2092 KLPHCSRV--CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHC----TP 2145
Query: 640 TPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC 699
WS P+C +K +P + L + Q G + F C EGF L G C
Sbjct: 2146 QGDWSPEAPRCTVKSCDDFLGQLPHG--RVLLPLNLQLGAKVSFVCDEGFRLKGRSASHC 2203
Query: 700 V-PGHPSQWTSQPPLCK 715
V G + W S P+C+
Sbjct: 2204 VLAGMKALWNSSVPVCE 2220
Score = 89.0 bits (219), Expect = 2e-17
Identities = 140/589 (23%), Positives = 222/589 (37%), Gaps = 122/589 (20%)
Query: 175 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 232
SC PP P +G V V TD+ G + C +G++L G + C L+G W+ + P C
Sbjct: 1453 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1512
Query: 233 A-SCG--GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDR 289
CG TI N I + G +T R + + GR++ FE V
Sbjct: 1513 RIPCGLPPTIANGDF--ISTNRENFHYGSVVTYRCNL-GSRGRKV---FELVG------- 1559
Query: 290 LMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 349
P IY + DD + G+ S PA ++ ++
Sbjct: 1560 ----------EPSIYCTSNDD--QVGIWSG------------PAPQCIIP--------NK 1587
Query: 350 CFAPFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPA 408
C P + +G + + + + + F C PG+ ++ P ++C + W P+
Sbjct: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP---RRVKCQALNK--WEPELPS 1642
Query: 409 CKAMCGGELSEPAGVVL----SPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGD 464
C +C +P +L +P ++SPGQ+ + + R + +GD
Sbjct: 1643 CSRVC-----QPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHC--TPQGD 1695
Query: 465 MLTLFDGDGPSARVLA--QLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFK 522
+ + P V + G P R+L L LQ A +GF L
Sbjct: 1696 ----WSPEAPRCAVKSCDDFLGQLPHGRVLFP---LNLQLGAKVSFV---CDEGFRLKGS 1745
Query: 523 EVPR----------NDT--------CPELPPPEWGWRTAS-HGDLIRGTVLTYQCEPG-- 561
V N++ CP P G T + GD+ G ++Y C+P
Sbjct: 1746 SVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPD 1805
Query: 562 ----YELLGSDILTCQWDLS----WSAAPPACQKIMT---CADPGEIANGHRTA--SDAG 608
+ L+G + C D WS+ P C+ + C P + T +D
Sbjct: 1806 RGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFE 1865
Query: 609 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 668
FPVG+ + Y C PGY ++C WS C K C P P NG
Sbjct: 1866 FPVGTSLNYECRPGY-FGKMFSISCLENLV----WSSVEDNCRRK--SCGPPPEPFNGMV 1918
Query: 669 TLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKV 716
+ Q G ++ + C EGF LIG + TC V G+ W + P+C++
Sbjct: 1919 HI-NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEI 1966
Score = 87.4 bits (215), Expect = 5e-17
Identities = 143/603 (23%), Positives = 229/603 (37%), Gaps = 113/603 (18%)
Query: 191 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC---MASCGGTIHNAT-LG 245
+L G F CD G+QL+G C L G WN P C I N G
Sbjct: 1275 NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTG 1334
Query: 246 RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYD 305
+ + P G N TC H +R + + +R P ++
Sbjct: 1335 KPLEVFPFGKA-VNYTC------------DPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 1381
Query: 306 SDMDDVPERGLISDAQS----LYVELLSETPAN--PLLLSLRFEAFEE--DRCFAPFLAH 357
S P G++ Q+ L+ +L ++T A+ P+ SL++E E R F+
Sbjct: 1382 SP---APRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 1438
Query: 358 GNV--------------TTTDP---------EYRPGALATFSCLPGYALEPPGPPNAIEC 394
V T DP + + G+ +SC G+ L ++ EC
Sbjct: 1439 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH---SSAEC 1495
Query: 395 V-DPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRIL 452
+ HW+ P C+ + CG + G +S + +++ G + ++ R +
Sbjct: 1496 ILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN-RENFHYGSVVTYRCNLGSRGRKV 1554
Query: 453 LQV----EILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP------DLTLQF 502
++ I D + ++ G P + + P +L S + ++F
Sbjct: 1555 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 1614
Query: 503 QAPPGPPNPGLGQGFVLHFKEVPRNDTC-------PELP--------PPE--WGWRTASH 545
+ PG FV+ + PR C PELP PPE G T SH
Sbjct: 1615 RCQPG---------FVM---KGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSH 1662
Query: 546 GDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRT 603
D G + Y CEPGY+L G+ L C WS P C + +C D G++ +G R
Sbjct: 1663 QDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC-AVKSCDDFLGQLPHG-RV 1720
Query: 604 ASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVP 663
+G+ V + C G+ L+G+++ C + W++ VP C ++ C NP
Sbjct: 1721 LFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRS-LWNNSVPVC--EHIFCPNPPAI 1777
Query: 664 ENGYQT-LYKHHYQAGESLRFFCYE------GFELIGEVTITCV--PGHPSQWTSQPPLC 714
NG T G+ + + C F LIGE TI C P W+S P C
Sbjct: 1778 LNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRC 1837
Query: 715 KVA 717
+++
Sbjct: 1838 ELS 1840
Score = 87.0 bits (214), Expect = 6e-17
Identities = 142/602 (23%), Positives = 228/602 (37%), Gaps = 113/602 (18%)
Query: 191 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC---MASCGGTIHNAT-LG 245
+L G F CD G+QL+G C L G WN P C I N G
Sbjct: 375 NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTG 434
Query: 246 RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYD 305
+ + P G N TC H +R + + +R P ++
Sbjct: 435 KPLEVFPFGKT-VNYTC------------DPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 481
Query: 306 SDMDDVPERGLISDAQS----LYVELLSETPAN--PLLLSLRFEAFEE--DRCFAPFLAH 357
S P G++ Q+ L+ +L ++T A+ P+ SL++E E R F+
Sbjct: 482 SP---APRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 538
Query: 358 GNV--------------TTTDP---------EYRPGALATFSCLPGYALEPPGPPNAIEC 394
V T DP + + G+ +SC G+ L ++ EC
Sbjct: 539 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH---SSAEC 595
Query: 395 V-DPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQ----DCVWGVHVQEE 448
+ HW+ P C+ + CG + G +S + +++ G C G ++
Sbjct: 596 ILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTN-RENFHYGSVVTYRCNPGSGGRKV 654
Query: 449 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP------DLTLQF 502
++ + I D + ++ G P + + P +L S + ++F
Sbjct: 655 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 714
Query: 503 QAPPGPPNPGLGQGFVLHFKEVPRNDTC-------PELP--------PPE--WGWRTASH 545
+ PG FV+ + PR C PELP PP+ RT
Sbjct: 715 RCQPG---------FVM---KGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRD 762
Query: 546 GDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRT 603
D G + Y CEPGY+L G+ + C WS A P C+ + +C D G++ NG R
Sbjct: 763 KDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE-VKSCDDFMGQLLNG-RV 820
Query: 604 ASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVP 663
+G+ V + C G+ L+G++ C + W+ VP C + C +P V
Sbjct: 821 LFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES-LWNSSVPVCEQIF--CPSPPVI 877
Query: 664 ENGYQT-LYKHHYQAGESLRFFC------YEGFELIGEVTITCV--PGHPSQWTSQPPLC 714
NG T + G+++ + C F+LIGE TI C P W+S P C
Sbjct: 878 PNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 937
Query: 715 KV 716
+
Sbjct: 938 GI 939
Score = 87.0 bits (214), Expect = 6e-17
Identities = 142/602 (23%), Positives = 228/602 (37%), Gaps = 113/602 (18%)
Query: 191 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC---MASCGGTIHNAT-LG 245
+L G F CD G+QL+G C L G WN P C I N G
Sbjct: 825 NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTG 884
Query: 246 RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYD 305
+ + P G N TC H +R + + +R P ++
Sbjct: 885 KPLEVFPFGKT-VNYTC------------DPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 931
Query: 306 SDMDDVPERGLISDAQS----LYVELLSETPAN--PLLLSLRFEAFEE--DRCFAPFLAH 357
S P G++ Q+ L+ +L ++T A+ P+ SL++E E R F+
Sbjct: 932 SP---APRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 988
Query: 358 GNV--------------TTTDP---------EYRPGALATFSCLPGYALEPPGPPNAIEC 394
V T DP + + G+ +SC G+ L ++ EC
Sbjct: 989 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH---SSAEC 1045
Query: 395 V-DPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQ----DCVWGVHVQEE 448
+ HW+ P C+ + CG + G +S + +++ G C G ++
Sbjct: 1046 ILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTN-RENFHYGSVVTYRCNPGSGGRKV 1104
Query: 449 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP------DLTLQF 502
++ + I D + ++ G P + + P +L S + ++F
Sbjct: 1105 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 1164
Query: 503 QAPPGPPNPGLGQGFVLHFKEVPRNDTC-------PELP--------PPE--WGWRTASH 545
+ PG FV+ + PR C PELP PP+ RT
Sbjct: 1165 RCQPG---------FVM---KGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRD 1212
Query: 546 GDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRT 603
D G + Y CEPGY+L G+ + C WS A P C+ + +C D G++ NG R
Sbjct: 1213 KDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE-VKSCDDFMGQLLNG-RV 1270
Query: 604 ASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVP 663
+G+ V + C G+ L+G++ C + W+ VP C + C +P V
Sbjct: 1271 LFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES-LWNSSVPVCEQIF--CPSPPVI 1327
Query: 664 ENGYQT-LYKHHYQAGESLRFFC------YEGFELIGEVTITCV--PGHPSQWTSQPPLC 714
NG T + G+++ + C F+LIGE TI C P W+S P C
Sbjct: 1328 PNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 1387
Query: 715 KV 716
+
Sbjct: 1388 GI 1389
Score = 81.3 bits (199), Expect = 3e-15
Identities = 136/577 (23%), Positives = 213/577 (36%), Gaps = 103/577 (17%)
Query: 175 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 232
SC PP P +G V V TD+ G + C +G++L G + C L+G W+ + P C
Sbjct: 553 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
Query: 233 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS-----LDEDN 287
G G +S ++ + GR++ FE V ++
Sbjct: 613 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV---FELVGEPSIYCTSND 669
Query: 288 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-----VE------LLSETPANPL 336
D++ + SG +P + +V L+SD +SL+ VE + + P
Sbjct: 670 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 729
Query: 337 LLSLRFEAFEEDRCF-----APFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPN 390
+L E C P + H T D + + PG +SC PGY L
Sbjct: 730 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA--- 786
Query: 391 AIECVDPTEPHWNDTEPACKA-MCGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEE 448
++ C + W+ P C+ C + + G VL P V++Q
Sbjct: 787 SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP---------------VNLQLG 829
Query: 449 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGP 508
++ + EG L G S VLA + L +S + Q P P
Sbjct: 830 AKVDFVCD-----EGFQL---KGSSASYCVLAGMES------LWNSSVPVCEQIFCPSPP 875
Query: 509 PNP-GLGQGFVLHFKEVPR--NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL 565
P G G L + N TC P P+ RGT ++L+
Sbjct: 876 VIPNGRHTGKPLEVFPFGKTVNYTCD--PHPD------------RGT--------SFDLI 913
Query: 566 GSDILTCQWDLS----WSAAPPACQKIMTCADPGE--IANGHRTASDAGFPVGSHVQYRC 619
G + C D WS+ P C + C P A + + FP+G+ ++Y C
Sbjct: 914 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 973
Query: 620 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGE 679
P Y +TC WS PK K + C P P NG + Q G
Sbjct: 974 RPEY-YGRPFSITCLDNLV----WSS--PKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGS 1025
Query: 680 SLRFFCYEGFELIGEVTITCV-PGHPSQWTSQPPLCK 715
+ + C G LIG + C+ G+ + W+++PP+C+
Sbjct: 1026 RINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 1062
Score = 81.3 bits (199), Expect = 3e-15
Identities = 136/577 (23%), Positives = 213/577 (36%), Gaps = 103/577 (17%)
Query: 175 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 232
SC PP P +G V V TD+ G + C +G++L G + C L+G W+ + P C
Sbjct: 1003 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 1062
Query: 233 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS-----LDEDN 287
G G +S ++ + GR++ FE V ++
Sbjct: 1063 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV---FELVGEPSIYCTSND 1119
Query: 288 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-----VE------LLSETPANPL 336
D++ + SG +P + +V L+SD +SL+ VE + + P
Sbjct: 1120 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 1179
Query: 337 LLSLRFEAFEEDRCF-----APFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPN 390
+L E C P + H T D + + PG +SC PGY L
Sbjct: 1180 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA--- 1236
Query: 391 AIECVDPTEPHWNDTEPACKA-MCGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEE 448
++ C + W+ P C+ C + + G VL P V++Q
Sbjct: 1237 SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP---------------VNLQLG 1279
Query: 449 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGP 508
++ + EG L G S VLA + L +S + Q P P
Sbjct: 1280 AKVDFVCD-----EGFQL---KGSSASYCVLAGMES------LWNSSVPVCEQIFCPSPP 1325
Query: 509 PNP-GLGQGFVLHFKEVPR--NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL 565
P G G L + N TC P P+ RGT ++L+
Sbjct: 1326 VIPNGRHTGKPLEVFPFGKAVNYTCD--PHPD------------RGT--------SFDLI 1363
Query: 566 GSDILTCQWDLS----WSAAPPACQKIMTCADPGE--IANGHRTASDAGFPVGSHVQYRC 619
G + C D WS+ P C + C P A + + FP+G+ ++Y C
Sbjct: 1364 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 1423
Query: 620 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGE 679
P Y +TC WS PK K + C P P NG + Q G
Sbjct: 1424 RPEY-YGRPFSITCLDNLV----WSS--PKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGS 1475
Query: 680 SLRFFCYEGFELIGEVTITCV-PGHPSQWTSQPPLCK 715
+ + C G LIG + C+ G+ + W+++PP+C+
Sbjct: 1476 RINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1512
Score = 80.5 bits (197), Expect = 6e-15
Identities = 137/577 (23%), Positives = 212/577 (36%), Gaps = 103/577 (17%)
Query: 175 SCGFPPRPAHGDVSVTD-LHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 232
SC PP P +G V V + G + C GY+L G + C ++G W+ ETP C
Sbjct: 103 SCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICD 162
Query: 233 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS-----LDEDN 287
G T G +S ++ + GR++ FE V ++
Sbjct: 163 RIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKV---FELVGEPSIYCTSND 219
Query: 288 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-----VE------LLSETPANPL 336
D++ + SG +P + +V L+SD +SL+ VE + + P
Sbjct: 220 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 279
Query: 337 LLSLRFEAFEEDRCF-----APFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPN 390
+L E C P + H T D + + PG +SC PGY L
Sbjct: 280 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA--- 336
Query: 391 AIECVDPTEPHWNDTEPACKA-MCGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEE 448
++ C + W+ P C+ C + + G VL P V++Q
Sbjct: 337 SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP---------------VNLQLG 379
Query: 449 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGP 508
++ + EG L G S VLA + L +S + Q P P
Sbjct: 380 AKVDFVCD-----EGFQL---KGSSASYCVLAGMES------LWNSSVPVCEQIFCPSPP 425
Query: 509 PNP-GLGQGFVLHFKEVPR--NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL 565
P G G L + N TC P P+ RGT ++L+
Sbjct: 426 VIPNGRHTGKPLEVFPFGKTVNYTCD--PHPD------------RGT--------SFDLI 463
Query: 566 GSDILTCQWDLS----WSAAPPACQKIMTCADPGE--IANGHRTASDAGFPVGSHVQYRC 619
G + C D WS+ P C + C P A + + FP+G+ ++Y C
Sbjct: 464 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 523
Query: 620 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGE 679
P Y +TC WS PK K + C P P NG + Q G
Sbjct: 524 RPEY-YGRPFSITCLDNLV----WSS--PKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGS 575
Query: 680 SLRFFCYEGFELIGEVTITCV-PGHPSQWTSQPPLCK 715
+ + C G LIG + C+ G+ + W+++PP+C+
Sbjct: 576 RINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
Score = 74.7 bits (182), Expect = 3e-13
Identities = 95/386 (24%), Positives = 154/386 (39%), Gaps = 59/386 (15%)
Query: 370 GALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPD 428
G+ +SC GY L G +A + W++ P C + CG + G +S +
Sbjct: 124 GSQIKYSCTKGYRLI--GSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTN 181
Query: 429 WPQSYSPGQ----DCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRG 484
+++ G C G ++ ++ + I D + ++ G P + +
Sbjct: 182 -RENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 240
Query: 485 PQPRRRLLSSGP------DLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC-------P 531
P +L S + ++F+ PG FV+ + PR C P
Sbjct: 241 PNVENGILVSDNRSLFSLNEVVEFRCQPG---------FVM---KGPRRVKCQALNKWEP 288
Query: 532 ELP--------PPE--WGWRTASHGDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSA 580
ELP PP+ RT D G + Y CEPGY+L G+ + C WS
Sbjct: 289 ELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 348
Query: 581 APPACQKIMTCAD-PGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTG 639
A P C+ + +C D G++ NG R +G+ V + C G+ L+G++ C
Sbjct: 349 AAPTCE-VKSCDDFMGQLLNG-RVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 406
Query: 640 TPKWSDRVPKCALKYEPCLNPGVPENGYQT-LYKHHYQAGESLRFFC------YEGFELI 692
+ W+ VP C + C +P V NG T + G+++ + C F+LI
Sbjct: 407 S-LWNSSVPVCEQIF--CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 463
Query: 693 GEVTITCV--PGHPSQWTSQPPLCKV 716
GE TI C P W+S P C +
Sbjct: 464 GESTIRCTSDPQGNGVWSSPAPRCGI 489
Score = 72.0 bits (175), Expect = 2e-12
Identities = 130/584 (22%), Positives = 205/584 (35%), Gaps = 72/584 (12%)
Query: 191 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM----------------- 232
+L G +F CD G++L+G C L G R WN P C
Sbjct: 1725 NLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTG 1784
Query: 233 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERV-SLDEDNDRLM 291
G + + P P + NL I H V S L
Sbjct: 1785 TPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDP----HGNGVWSSPAPRCELS 1840
Query: 292 VRSGGSPL-------SPVIYDSDMDDVPERGLISDAQSLYV-ELLSETPANPLLLSLRFE 343
VR+G SP I +D + L + + Y ++ S + L+ S +
Sbjct: 1841 VRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVED 1900
Query: 344 AFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWN 403
C P + + + + G+ +SC G+ L G P+ V W+
Sbjct: 1901 NCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLI--GSPSTTCLVSGNNVTWD 1958
Query: 404 DTEPACKAMCGGELSEPAGVVLSPDWPQ----SYSPGQDCVWGVHVQEEKRILLQV---- 455
P C+ + EP + + D+ S+ G + H + L ++
Sbjct: 1959 KKAPICEIIS----CEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGER 2014
Query: 456 EILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP----DLT--LQFQAPPGPP 509
I + D + ++ P + P+ + G LT ++F+ PG
Sbjct: 2015 SIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFV 2074
Query: 510 NPGLGQ-GFVLHFKEVPRNDTCPEL--PPPE--WGWRTASHGDLIR-GTVLTYQCEPGYE 563
G + + P+ C + PPPE G T SH D G + Y CEP Y+
Sbjct: 2075 MVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYD 2134
Query: 564 LLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRTASDAGFPVGSHVQYRCLPG 622
L G+ L C WS P C + +C D G++ +G R +G+ V + C G
Sbjct: 2135 LRGAASLHCTPQGDWSPEAPRC-TVKSCDDFLGQLPHG-RVLLPLNLQLGAKVSFVCDEG 2192
Query: 623 YSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKH-HYQAGESL 681
+ L+G + C W+ VP C + C NP NG T G+ +
Sbjct: 2193 FRLKGRSASHCVLAGM-KALWNSSVPVCEQIF--CPNPPAILNGRHTGTPFGDIPYGKEI 2249
Query: 682 RFFCYE------GFELIGEVTITCV--PGHPSQWTSQPPLCKVA 717
+ C F LIGE +I C P W+S P C+++
Sbjct: 2250 SYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELS 2293
Score = 68.9 bits (167), Expect = 2e-11
Identities = 62/229 (27%), Positives = 91/229 (39%), Gaps = 26/229 (11%)
Query: 505 PPGPPNPGL----GQGFVLHFKEVPRNDTCPELPPPEW-----GWRTASHGDLIRGTVLT 555
P GPP PGL G + + + PEW + GT L
Sbjct: 11 PVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLN 70
Query: 556 YQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHV 615
Y+C PGY I+ C + W+ A C++ +C +P + NG G GS +
Sbjct: 71 YECRPGYSGRPFSII-CLKNSVWTGAKDRCRR-KSCRNPPDPVNG-MVHVIKGIQFGSQI 127
Query: 616 QYRCLPGYSLEGAAMLTC-YSRDTGTPKWSDRVPKCALKYEPC-LNPGVPENGYQTLYKH 673
+Y C GY L G++ TC S DT W + P C PC L P + + + +
Sbjct: 128 KYSCTKGYRLIGSSSATCIISGDTVI--WDNETPIC--DRIPCGLPPTITNGDFISTNRE 183
Query: 674 HYQAGESLRFFCYEG------FELIGEVTITCVPGHPSQ--WTSQPPLC 714
++ G + + C G FEL+GE +I C W+ P C
Sbjct: 184 NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC 232
Score = 65.5 bits (158), Expect = 2e-10
Identities = 47/177 (26%), Positives = 75/177 (42%), Gaps = 15/177 (8%)
Query: 551 GTVLTYQCEPGYELLGSDILTCQ---WDLSWSAAPPACQKIMTCADPGEIANGHRTASDA 607
G +++ C+ G+ L G C W+++ P C++I C +P I NG T +
Sbjct: 2182 GAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIF-CPNPPAILNGRHTGTPF 2240
Query: 608 G-FPVGSHVQYRCLPG------YSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEP-CLN 659
G P G + Y C ++L G + + C S G WS P+C L C +
Sbjct: 2241 GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPH 2300
Query: 660 PGVPENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 715
P +NG Y + Y G ++ + C G+ L+G+ I C W+ CK
Sbjct: 2301 PPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCT--DQGIWSQLDHYCK 2355
Score = 52.4 bits (124), Expect = 2e-06
Identities = 37/135 (27%), Positives = 57/135 (42%), Gaps = 9/135 (6%)
Query: 530 CPELPPPEWGWRTASHGDL-IRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 588
CP P + G H L + G ++Y C+PGY L+G + C WS C+++
Sbjct: 2298 CPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEV 2357
Query: 589 MTCADPGEIANG--HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 646
C+ P NG + G +V +C GY+LEG+ C + D +W
Sbjct: 2358 -NCSFP-LFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADD----RWDPP 2411
Query: 647 VPKCALKYEPCLNPG 661
+ KC + L G
Sbjct: 2412 LAKCTSRTHDALIVG 2426
Score = 46.6 bits (109), Expect = 9e-05
Identities = 24/64 (37%), Positives = 36/64 (56%), Gaps = 3/64 (4%)
Query: 175 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSC- 231
SCG PP P +G V + TD G T + C+ G++L G + CL +G +W+ + P C
Sbjct: 1906 SCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICE 1965
Query: 232 MASC 235
+ SC
Sbjct: 1966 IISC 1969
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/112 (26%), Positives = 44/112 (39%), Gaps = 11/112 (9%)
Query: 149 GEEETTTTIITTTTVTTTVTSPAYLLSCGFPPRPAHGDVSVT---DLHPGGTATFHCDSG 205
G T I T + T + CG PP +GD T + H G T+ C+ G
Sbjct: 139 GSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPG 198
Query: 206 ------YQLQGEETLICLNGTRP--SWNGETPSCMASCGGTIHNATLGRIVS 249
++L GE ++ C + W+G P C+ T N G +VS
Sbjct: 199 SGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVS 250
Score = 41.2 bits (95), Expect = 0.004
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 11/87 (12%)
Query: 174 LSCGFPPRPAHGDVSVT---DLHPGGTATFHCDSG------YQLQGEETLICLNGTRP-- 222
+ CG PP A+GD T + H G T+ C+ G ++L GE ++ C +
Sbjct: 614 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 673
Query: 223 SWNGETPSCMASCGGTIHNATLGRIVS 249
W+G P C+ T N G +VS
Sbjct: 674 IWSGPAPQCIIPNKCTPPNVENGILVS 700
Score = 41.2 bits (95), Expect = 0.004
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 11/87 (12%)
Query: 174 LSCGFPPRPAHGDVSVT---DLHPGGTATFHCDSG------YQLQGEETLICLNGTRP-- 222
+ CG PP A+GD T + H G T+ C+ G ++L GE ++ C +
Sbjct: 1064 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 1123
Query: 223 SWNGETPSCMASCGGTIHNATLGRIVS 249
W+G P C+ T N G +VS
Sbjct: 1124 IWSGPAPQCIIPNKCTPPNVENGILVS 1150
Score = 40.8 bits (94), Expect = 0.005
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 11/87 (12%)
Query: 174 LSCGFPPRPAHGDVSVT---DLHPGGTATFHCDSG------YQLQGEETLICLNGTRP-- 222
+ CG PP A+GD T + H G T+ C+ G ++L GE ++ C +
Sbjct: 1514 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVG 1573
Query: 223 SWNGETPSCMASCGGTIHNATLGRIVS 249
W+G P C+ T N G +VS
Sbjct: 1574 IWSGPAPQCIIPNKCTPPNVENGILVS 1600
>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
Length = 2039
Score = 102 bits (255), Expect = 1e-21
Identities = 146/617 (23%), Positives = 225/617 (36%), Gaps = 120/617 (19%)
Query: 176 CGFPPRPAHGDVSVT---DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC- 231
C PP HG+ + + + PG + C+ GY L+G +L C + W+ E P C
Sbjct: 1197 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCT--PQGDWSPEAPRCA 1254
Query: 232 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRL------HLHF------- 278
+ SC + GR++ P + L + EG RL H
Sbjct: 1255 VKSCDDFLGQLPHGRVLFP-----LNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLW 1309
Query: 279 -------ERVSLDEDNDRLMVRSGGSPLSPVIYDSDM----DDVPERGL---------IS 318
E + L R G+P + Y ++ D P+RG+ I
Sbjct: 1310 NNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIR 1369
Query: 319 DAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCL 378
+ + +PA LS+R + F PF A + D E+ G + C
Sbjct: 1370 CTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQF-PF-ASPTIPINDFEFPVGTSLNYECR 1427
Query: 379 PGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSY----- 433
PGY G +I C++ W+ E C+ G EP ++ + +
Sbjct: 1428 PGYF----GKMFSISCLENLV--WSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVN 1481
Query: 434 -----------SPGQDC-VWGVHVQEEKRILLQVEILNVR-------------------E 462
SP C V G +V +K+ + EI++
Sbjct: 1482 YSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPI-CEIISCEPPPTISNGDFYSNNRTSFHN 1540
Query: 463 GDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFK 522
G ++T GP L +L G R + + D + + P P +
Sbjct: 1541 GTVVTYQCHTGPDGEQLFELVG---ERSIYCTSKDDQVGVWSSPPP-------------R 1584
Query: 523 EVPRND-TCPELPPPEWGWRTASHGDLIRGT-VLTYQCEPGYELLGSDILTCQWDLSWSA 580
+ N T PE+ E R + T ++ ++C+PG+ ++GS + CQ + W
Sbjct: 1585 CISTNKCTAPEV---ENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGP 1641
Query: 581 APPACQKIMTCADPGEIANGHRTAS-DAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTG 639
P C ++ C P EI +G T S F G V Y C P Y L GAA L C T
Sbjct: 1642 KLPHCSRV--CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHC----TP 1695
Query: 640 TPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC 699
WS P+C +K +P + L + Q G + F C EGF L G C
Sbjct: 1696 QGDWSPEAPRCTVKSCDDFLGQLPHG--RVLLPLNLQLGAKVSFVCDEGFRLKGRSASHC 1753
Query: 700 V-PGHPSQWTSQPPLCK 715
V G + W S P+C+
Sbjct: 1754 VLAGMKALWNSSVPVCE 1770
Score = 89.0 bits (219), Expect = 2e-17
Identities = 140/589 (23%), Positives = 222/589 (37%), Gaps = 122/589 (20%)
Query: 175 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 232
SC PP P +G V V TD+ G + C +G++L G + C L+G W+ + P C
Sbjct: 1003 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1062
Query: 233 A-SCG--GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDR 289
CG TI N I + G +T R + + GR++ FE V
Sbjct: 1063 RIPCGLPPTIANGDF--ISTNRENFHYGSVVTYRCNL-GSRGRKV---FELVG------- 1109
Query: 290 LMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 349
P IY + DD + G+ S PA ++ ++
Sbjct: 1110 ----------EPSIYCTSNDD--QVGIWSG------------PAPQCIIP--------NK 1137
Query: 350 CFAPFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPA 408
C P + +G + + + + + F C PG+ ++ P ++C + W P+
Sbjct: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP---RRVKCQALNK--WEPELPS 1192
Query: 409 CKAMCGGELSEPAGVVL----SPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGD 464
C +C +P +L +P ++SPGQ+ + + R + +GD
Sbjct: 1193 CSRVC-----QPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHC--TPQGD 1245
Query: 465 MLTLFDGDGPSARVLA--QLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFK 522
+ + P V + G P R+L L LQ A +GF L
Sbjct: 1246 ----WSPEAPRCAVKSCDDFLGQLPHGRVLFP---LNLQLGAKVSFV---CDEGFRLKGS 1295
Query: 523 EVPR----------NDT--------CPELPPPEWGWRTAS-HGDLIRGTVLTYQCEPG-- 561
V N++ CP P G T + GD+ G ++Y C+P
Sbjct: 1296 SVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPD 1355
Query: 562 ----YELLGSDILTCQWDLS----WSAAPPACQKIMT---CADPGEIANGHRTA--SDAG 608
+ L+G + C D WS+ P C+ + C P + T +D
Sbjct: 1356 RGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFE 1415
Query: 609 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 668
FPVG+ + Y C PGY ++C WS C K C P P NG
Sbjct: 1416 FPVGTSLNYECRPGY-FGKMFSISCLENLV----WSSVEDNCRRK--SCGPPPEPFNGMV 1468
Query: 669 TLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKV 716
+ Q G ++ + C EGF LIG + TC V G+ W + P+C++
Sbjct: 1469 HI-NTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEI 1516
Score = 87.4 bits (215), Expect = 5e-17
Identities = 143/603 (23%), Positives = 229/603 (37%), Gaps = 113/603 (18%)
Query: 191 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC---MASCGGTIHNAT-LG 245
+L G F CD G+QL+G C L G WN P C I N G
Sbjct: 825 NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTG 884
Query: 246 RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYD 305
+ + P G N TC H +R + + +R P ++
Sbjct: 885 KPLEVFPFGKA-VNYTC------------DPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 931
Query: 306 SDMDDVPERGLISDAQS----LYVELLSETPAN--PLLLSLRFEAFEE--DRCFAPFLAH 357
S P G++ Q+ L+ +L ++T A+ P+ SL++E E R F+
Sbjct: 932 SP---APRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 988
Query: 358 GNV--------------TTTDP---------EYRPGALATFSCLPGYALEPPGPPNAIEC 394
V T DP + + G+ +SC G+ L ++ EC
Sbjct: 989 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH---SSAEC 1045
Query: 395 V-DPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRIL 452
+ HW+ P C+ + CG + G +S + +++ G + ++ R +
Sbjct: 1046 ILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN-RENFHYGSVVTYRCNLGSRGRKV 1104
Query: 453 LQV----EILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP------DLTLQF 502
++ I D + ++ G P + + P +L S + ++F
Sbjct: 1105 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 1164
Query: 503 QAPPGPPNPGLGQGFVLHFKEVPRNDTC-------PELP--------PPE--WGWRTASH 545
+ PG FV+ + PR C PELP PPE G T SH
Sbjct: 1165 RCQPG---------FVM---KGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSH 1212
Query: 546 GDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRT 603
D G + Y CEPGY+L G+ L C WS P C + +C D G++ +G R
Sbjct: 1213 QDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC-AVKSCDDFLGQLPHG-RV 1270
Query: 604 ASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVP 663
+G+ V + C G+ L+G+++ C + W++ VP C ++ C NP
Sbjct: 1271 LFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRS-LWNNSVPVC--EHIFCPNPPAI 1327
Query: 664 ENGYQT-LYKHHYQAGESLRFFCYE------GFELIGEVTITCV--PGHPSQWTSQPPLC 714
NG T G+ + + C F LIGE TI C P W+S P C
Sbjct: 1328 LNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRC 1387
Query: 715 KVA 717
+++
Sbjct: 1388 ELS 1390
Score = 87.0 bits (214), Expect = 6e-17
Identities = 142/602 (23%), Positives = 228/602 (37%), Gaps = 113/602 (18%)
Query: 191 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC---MASCGGTIHNAT-LG 245
+L G F CD G+QL+G C L G WN P C I N G
Sbjct: 375 NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTG 434
Query: 246 RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYD 305
+ + P G N TC H +R + + +R P ++
Sbjct: 435 KPLEVFPFGKT-VNYTC------------DPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 481
Query: 306 SDMDDVPERGLISDAQS----LYVELLSETPAN--PLLLSLRFEAFEE--DRCFAPFLAH 357
S P G++ Q+ L+ +L ++T A+ P+ SL++E E R F+
Sbjct: 482 SP---APRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 538
Query: 358 GNV--------------TTTDP---------EYRPGALATFSCLPGYALEPPGPPNAIEC 394
V T DP + + G+ +SC G+ L ++ EC
Sbjct: 539 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH---SSAEC 595
Query: 395 V-DPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQ----DCVWGVHVQEE 448
+ HW+ P C+ + CG + G +S + +++ G C G ++
Sbjct: 596 ILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTN-RENFHYGSVVTYRCNPGSGGRKV 654
Query: 449 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP------DLTLQF 502
++ + I D + ++ G P + + P +L S + ++F
Sbjct: 655 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 714
Query: 503 QAPPGPPNPGLGQGFVLHFKEVPRNDTC-------PELP--------PPE--WGWRTASH 545
+ PG FV+ + PR C PELP PP+ RT
Sbjct: 715 RCQPG---------FVM---KGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRD 762
Query: 546 GDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRT 603
D G + Y CEPGY+L G+ + C WS A P C+ + +C D G++ NG R
Sbjct: 763 KDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE-VKSCDDFMGQLLNG-RV 820
Query: 604 ASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVP 663
+G+ V + C G+ L+G++ C + W+ VP C + C +P V
Sbjct: 821 LFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES-LWNSSVPVCEQIF--CPSPPVI 877
Query: 664 ENGYQT-LYKHHYQAGESLRFFC------YEGFELIGEVTITCV--PGHPSQWTSQPPLC 714
NG T + G+++ + C F+LIGE TI C P W+S P C
Sbjct: 878 PNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 937
Query: 715 KV 716
+
Sbjct: 938 GI 939
Score = 81.3 bits (199), Expect = 3e-15
Identities = 136/577 (23%), Positives = 213/577 (36%), Gaps = 103/577 (17%)
Query: 175 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 232
SC PP P +G V V TD+ G + C +G++L G + C L+G W+ + P C
Sbjct: 553 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
Query: 233 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS-----LDEDN 287
G G +S ++ + GR++ FE V ++
Sbjct: 613 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV---FELVGEPSIYCTSND 669
Query: 288 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-----VE------LLSETPANPL 336
D++ + SG +P + +V L+SD +SL+ VE + + P
Sbjct: 670 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 729
Query: 337 LLSLRFEAFEEDRCF-----APFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPN 390
+L E C P + H T D + + PG +SC PGY L
Sbjct: 730 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA--- 786
Query: 391 AIECVDPTEPHWNDTEPACKA-MCGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEE 448
++ C + W+ P C+ C + + G VL P V++Q
Sbjct: 787 SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP---------------VNLQLG 829
Query: 449 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGP 508
++ + EG L G S VLA + L +S + Q P P
Sbjct: 830 AKVDFVCD-----EGFQL---KGSSASYCVLAGMES------LWNSSVPVCEQIFCPSPP 875
Query: 509 PNP-GLGQGFVLHFKEVPR--NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL 565
P G G L + N TC P P+ RGT ++L+
Sbjct: 876 VIPNGRHTGKPLEVFPFGKAVNYTCD--PHPD------------RGT--------SFDLI 913
Query: 566 GSDILTCQWDLS----WSAAPPACQKIMTCADPGE--IANGHRTASDAGFPVGSHVQYRC 619
G + C D WS+ P C + C P A + + FP+G+ ++Y C
Sbjct: 914 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 973
Query: 620 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGE 679
P Y +TC WS PK K + C P P NG + Q G
Sbjct: 974 RPEY-YGRPFSITCLDNLV----WSS--PKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGS 1025
Query: 680 SLRFFCYEGFELIGEVTITCV-PGHPSQWTSQPPLCK 715
+ + C G LIG + C+ G+ + W+++PP+C+
Sbjct: 1026 RINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1062
Score = 80.5 bits (197), Expect = 6e-15
Identities = 137/577 (23%), Positives = 212/577 (36%), Gaps = 103/577 (17%)
Query: 175 SCGFPPRPAHGDVSVTD-LHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 232
SC PP P +G V V + G + C GY+L G + C ++G W+ ETP C
Sbjct: 103 SCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICD 162
Query: 233 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS-----LDEDN 287
G T G +S ++ + GR++ FE V ++
Sbjct: 163 RIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKV---FELVGEPSIYCTSND 219
Query: 288 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-----VE------LLSETPANPL 336
D++ + SG +P + +V L+SD +SL+ VE + + P
Sbjct: 220 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 279
Query: 337 LLSLRFEAFEEDRCF-----APFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPN 390
+L E C P + H T D + + PG +SC PGY L
Sbjct: 280 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA--- 336
Query: 391 AIECVDPTEPHWNDTEPACKA-MCGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEE 448
++ C + W+ P C+ C + + G VL P V++Q
Sbjct: 337 SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP---------------VNLQLG 379
Query: 449 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGP 508
++ + EG L G S VLA + L +S + Q P P
Sbjct: 380 AKVDFVCD-----EGFQL---KGSSASYCVLAGMES------LWNSSVPVCEQIFCPSPP 425
Query: 509 PNP-GLGQGFVLHFKEVPR--NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL 565
P G G L + N TC P P+ RGT ++L+
Sbjct: 426 VIPNGRHTGKPLEVFPFGKTVNYTCD--PHPD------------RGT--------SFDLI 463
Query: 566 GSDILTCQWDLS----WSAAPPACQKIMTCADPGE--IANGHRTASDAGFPVGSHVQYRC 619
G + C D WS+ P C + C P A + + FP+G+ ++Y C
Sbjct: 464 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 523
Query: 620 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGE 679
P Y +TC WS PK K + C P P NG + Q G
Sbjct: 524 RPEY-YGRPFSITCLDNLV----WSS--PKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGS 575
Query: 680 SLRFFCYEGFELIGEVTITCV-PGHPSQWTSQPPLCK 715
+ + C G LIG + C+ G+ + W+++PP+C+
Sbjct: 576 RINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
Score = 74.7 bits (182), Expect = 3e-13
Identities = 95/386 (24%), Positives = 154/386 (39%), Gaps = 59/386 (15%)
Query: 370 GALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPD 428
G+ +SC GY L G +A + W++ P C + CG + G +S +
Sbjct: 124 GSQIKYSCTKGYRLI--GSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTN 181
Query: 429 WPQSYSPGQ----DCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRG 484
+++ G C G ++ ++ + I D + ++ G P + +
Sbjct: 182 -RENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 240
Query: 485 PQPRRRLLSSGP------DLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC-------P 531
P +L S + ++F+ PG FV+ + PR C P
Sbjct: 241 PNVENGILVSDNRSLFSLNEVVEFRCQPG---------FVM---KGPRRVKCQALNKWEP 288
Query: 532 ELP--------PPE--WGWRTASHGDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSA 580
ELP PP+ RT D G + Y CEPGY+L G+ + C WS
Sbjct: 289 ELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 348
Query: 581 APPACQKIMTCAD-PGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTG 639
A P C+ + +C D G++ NG R +G+ V + C G+ L+G++ C
Sbjct: 349 AAPTCE-VKSCDDFMGQLLNG-RVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 406
Query: 640 TPKWSDRVPKCALKYEPCLNPGVPENGYQT-LYKHHYQAGESLRFFC------YEGFELI 692
+ W+ VP C + C +P V NG T + G+++ + C F+LI
Sbjct: 407 S-LWNSSVPVCEQIF--CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 463
Query: 693 GEVTITCV--PGHPSQWTSQPPLCKV 716
GE TI C P W+S P C +
Sbjct: 464 GESTIRCTSDPQGNGVWSSPAPRCGI 489
Score = 72.0 bits (175), Expect = 2e-12
Identities = 130/584 (22%), Positives = 205/584 (35%), Gaps = 72/584 (12%)
Query: 191 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM----------------- 232
+L G +F CD G++L+G C L G R WN P C
Sbjct: 1275 NLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTG 1334
Query: 233 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERV-SLDEDNDRLM 291
G + + P P + NL I H V S L
Sbjct: 1335 TPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDP----HGNGVWSSPAPRCELS 1390
Query: 292 VRSGGSPL-------SPVIYDSDMDDVPERGLISDAQSLYV-ELLSETPANPLLLSLRFE 343
VR+G SP I +D + L + + Y ++ S + L+ S +
Sbjct: 1391 VRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVED 1450
Query: 344 AFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWN 403
C P + + + + G+ +SC G+ L G P+ V W+
Sbjct: 1451 NCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLI--GSPSTTCLVSGNNVTWD 1508
Query: 404 DTEPACKAMCGGELSEPAGVVLSPDWPQ----SYSPGQDCVWGVHVQEEKRILLQV---- 455
P C+ + EP + + D+ S+ G + H + L ++
Sbjct: 1509 KKAPICEIIS----CEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGER 1564
Query: 456 EILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP----DLT--LQFQAPPGPP 509
I + D + ++ P + P+ + G LT ++F+ PG
Sbjct: 1565 SIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFV 1624
Query: 510 NPGLGQ-GFVLHFKEVPRNDTCPEL--PPPE--WGWRTASHGDLIR-GTVLTYQCEPGYE 563
G + + P+ C + PPPE G T SH D G + Y CEP Y+
Sbjct: 1625 MVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYD 1684
Query: 564 LLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRTASDAGFPVGSHVQYRCLPG 622
L G+ L C WS P C + +C D G++ +G R +G+ V + C G
Sbjct: 1685 LRGAASLHCTPQGDWSPEAPRC-TVKSCDDFLGQLPHG-RVLLPLNLQLGAKVSFVCDEG 1742
Query: 623 YSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKH-HYQAGESL 681
+ L+G + C W+ VP C + C NP NG T G+ +
Sbjct: 1743 FRLKGRSASHCVLAGM-KALWNSSVPVCEQIF--CPNPPAILNGRHTGTPFGDIPYGKEI 1799
Query: 682 RFFCYE------GFELIGEVTITCV--PGHPSQWTSQPPLCKVA 717
+ C F LIGE +I C P W+S P C+++
Sbjct: 1800 SYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELS 1843
Score = 68.9 bits (167), Expect = 2e-11
Identities = 62/229 (27%), Positives = 91/229 (39%), Gaps = 26/229 (11%)
Query: 505 PPGPPNPGL----GQGFVLHFKEVPRNDTCPELPPPEW-----GWRTASHGDLIRGTVLT 555
P GPP PGL G + + + PEW + GT L
Sbjct: 11 PVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLN 70
Query: 556 YQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHV 615
Y+C PGY I+ C + W+ A C++ +C +P + NG G GS +
Sbjct: 71 YECRPGYSGRPFSII-CLKNSVWTGAKDRCRR-KSCRNPPDPVNG-MVHVIKGIQFGSQI 127
Query: 616 QYRCLPGYSLEGAAMLTC-YSRDTGTPKWSDRVPKCALKYEPC-LNPGVPENGYQTLYKH 673
+Y C GY L G++ TC S DT W + P C PC L P + + + +
Sbjct: 128 KYSCTKGYRLIGSSSATCIISGDTVI--WDNETPIC--DRIPCGLPPTITNGDFISTNRE 183
Query: 674 HYQAGESLRFFCYEG------FELIGEVTITCVPGHPSQ--WTSQPPLC 714
++ G + + C G FEL+GE +I C W+ P C
Sbjct: 184 NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC 232
Score = 65.5 bits (158), Expect = 2e-10
Identities = 47/177 (26%), Positives = 75/177 (42%), Gaps = 15/177 (8%)
Query: 551 GTVLTYQCEPGYELLGSDILTCQ---WDLSWSAAPPACQKIMTCADPGEIANGHRTASDA 607
G +++ C+ G+ L G C W+++ P C++I C +P I NG T +
Sbjct: 1732 GAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIF-CPNPPAILNGRHTGTPF 1790
Query: 608 G-FPVGSHVQYRCLPG------YSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEP-CLN 659
G P G + Y C ++L G + + C S G WS P+C L C +
Sbjct: 1791 GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPH 1850
Query: 660 PGVPENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 715
P +NG Y + Y G ++ + C G+ L+G+ I C W+ CK
Sbjct: 1851 PPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCT--DQGIWSQLDHYCK 1905
Score = 52.4 bits (124), Expect = 2e-06
Identities = 37/135 (27%), Positives = 57/135 (42%), Gaps = 9/135 (6%)
Query: 530 CPELPPPEWGWRTASHGDL-IRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 588
CP P + G H L + G ++Y C+PGY L+G + C WS C+++
Sbjct: 1848 CPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEV 1907
Query: 589 MTCADPGEIANG--HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 646
C+ P NG + G +V +C GY+LEG+ C + D +W
Sbjct: 1908 -NCSFP-LFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADD----RWDPP 1961
Query: 647 VPKCALKYEPCLNPG 661
+ KC + L G
Sbjct: 1962 LAKCTSRTHDALIVG 1976
Score = 46.6 bits (109), Expect = 9e-05
Identities = 24/64 (37%), Positives = 36/64 (56%), Gaps = 3/64 (4%)
Query: 175 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSC- 231
SCG PP P +G V + TD G T + C+ G++L G + CL +G +W+ + P C
Sbjct: 1456 SCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICE 1515
Query: 232 MASC 235
+ SC
Sbjct: 1516 IISC 1519
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/112 (26%), Positives = 44/112 (39%), Gaps = 11/112 (9%)
Query: 149 GEEETTTTIITTTTVTTTVTSPAYLLSCGFPPRPAHGDVSVT---DLHPGGTATFHCDSG 205
G T I T + T + CG PP +GD T + H G T+ C+ G
Sbjct: 139 GSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPG 198
Query: 206 ------YQLQGEETLICLNGTRP--SWNGETPSCMASCGGTIHNATLGRIVS 249
++L GE ++ C + W+G P C+ T N G +VS
Sbjct: 199 SGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVS 250
Score = 41.2 bits (95), Expect = 0.004
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 11/87 (12%)
Query: 174 LSCGFPPRPAHGDVSVT---DLHPGGTATFHCDSG------YQLQGEETLICLNGTRP-- 222
+ CG PP A+GD T + H G T+ C+ G ++L GE ++ C +
Sbjct: 614 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 673
Query: 223 SWNGETPSCMASCGGTIHNATLGRIVS 249
W+G P C+ T N G +VS
Sbjct: 674 IWSGPAPQCIIPNKCTPPNVENGILVS 700
Score = 40.8 bits (94), Expect = 0.005
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 11/87 (12%)
Query: 174 LSCGFPPRPAHGDVSVT---DLHPGGTATFHCDSG------YQLQGEETLICLNGTRP-- 222
+ CG PP A+GD T + H G T+ C+ G ++L GE ++ C +
Sbjct: 1064 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVG 1123
Query: 223 SWNGETPSCMASCGGTIHNATLGRIVS 249
W+G P C+ T N G +VS
Sbjct: 1124 IWSGPAPQCIIPNKCTPPNVENGILVS 1150
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 98.6 bits (244), Expect = 2e-20
Identities = 166/693 (23%), Positives = 250/693 (36%), Gaps = 126/693 (18%)
Query: 78 LATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAPELLTPPPGTTAPPPPSP 137
L TPP + VP A G+ + V +RG T L P GT + P P
Sbjct: 2380 LCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTT----LCQPDGTWSSPLPEC 2435
Query: 138 AS---PGPPLGPEG-----GEEETTTTIITT--------TTVTTTVTSPAYL-------- 173
P P P G G +T + T T T + +L
Sbjct: 2436 VPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKA 2495
Query: 174 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMA 233
+ C P +G S TDLH G T T+ C+ G++L+G L CL W+ + PSC A
Sbjct: 2496 IECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLE--TGDWDVDAPSCNA 2553
Query: 234 SCGGTIHNATLGRIVSPEP---GGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290
IH SP+P G G + + +I ++ F + +
Sbjct: 2554 -----IH------CDSPQPIENGFVEGADYSYGAII-------IYSCFPGFQVAGHAMQT 2595
Query: 291 MVRSGGSPLSPVIYDSDMD-----DVPERGLISDAQSLY------VELLSETPANPLLLS 339
SG S P D D + + D Q + +E+ TP P L
Sbjct: 2596 CEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLG 2655
Query: 340 LRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTE 399
+ +E + + T + G + +++C PGY L G P I D T
Sbjct: 2656 AVAKTWENTK--------ESPATHSSNFLYGTMVSYTCNPGYEL--LGNPVLICQEDGT- 2704
Query: 400 PHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEIL 458
WN + P+C ++ C + G + + + C G H+ + L +E
Sbjct: 2705 --WNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPG-HILAGSDLRLCLENR 2761
Query: 459 NVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDL----TLQFQAPPGPPNPGLG 514
+ G P ++ + P P G + TL ++ PG G
Sbjct: 2762 K---------WSGASPRCEAIS-CKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTE 2811
Query: 515 QGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQ------CEPGYELLGSD 568
+ K ++ P P + S +RG T+Q C G+ L G+
Sbjct: 2812 RRTCQDDKNWDEDE--PICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGAR 2869
Query: 569 ILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGA 628
C + SWS A P C + CA P ++ANG D GF V + C GY L GA
Sbjct: 2870 SRVCLANGSWSGATPDCVPV-RCATPPQLANGVTEGLDYGFM--KEVTFHCHEGYILHGA 2926
Query: 629 AMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE-------NGYQTLYKHHYQAGESL 681
LTC S W +P C +P +N G PE NG+ ++ H Q
Sbjct: 2927 PKLTCQS----DGNWDAEIPLC----KP-VNCGPPEDLAHGFPNGFSFIHGGHIQ----- 2972
Query: 682 RFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 714
+ C+ G++L G + C+ W+ P C
Sbjct: 2973 -YQCFPGYKLHGNSSRRCLSN--GSWSGSSPSC 3002
Score = 94.4 bits (233), Expect = 4e-19
Identities = 57/162 (35%), Positives = 80/162 (49%), Gaps = 14/162 (8%)
Query: 554 LTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGS 613
+T+ C GY L G+ LTCQ D +W A P C K + C P ++A+G + F G
Sbjct: 2913 VTFHCHEGYILHGAPKLTCQSDGNWDAEIPLC-KPVNCGPPEDLAHGF--PNGFSFIHGG 2969
Query: 614 HVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKH 673
H+QY+C PGY L G + C S + WS P C PC P Y T+
Sbjct: 2970 HIQYQCFPGYKLHGNSSRRCLSNGS----WSGSSPSCL----PC-RCSTPVIEYGTVNGT 3020
Query: 674 HYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 715
+ G++ R C++GF+L+G ITC QW+S P C+
Sbjct: 3021 DFDCGKAARIQCFKGFKLLGLSEITCEA--DGQWSSGFPHCE 3060
Score = 89.4 bits (220), Expect = 1e-17
Identities = 65/241 (26%), Positives = 100/241 (41%), Gaps = 57/241 (23%)
Query: 529 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 588
+C PP E G+ +A D G+ +TYQC GY LLG + C + SW+ P+C +
Sbjct: 1689 SCGVPPPLENGFHSAD--DFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDV 1746
Query: 589 MTCA----------------------------------------DPGEIANGHRTASDAG 608
CA PG NGH +S
Sbjct: 1747 DECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGH--SSGEI 1804
Query: 609 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 668
+ VG+ V + C GY L G +TC + +W+ +P C K C P +PENG
Sbjct: 1805 YTVGAEVTFSCQEGYQLMGVTKITCLE----SGEWNHLIPYC--KAVSCGKPAIPENG-- 1856
Query: 669 TLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC---KVAYEELLDNR 725
+ + + G + + C +G+ L G+ +C+ S W+ PP+C K + E ++N
Sbjct: 1857 CIEELAFTFGSKVTYRCNKGYTLAGDKESSCLAN--SSWSHSPPVCEPVKCSSPENINNG 1914
Query: 726 K 726
K
Sbjct: 1915 K 1915
Score = 86.3 bits (212), Expect = 1e-16
Identities = 61/189 (32%), Positives = 84/189 (44%), Gaps = 14/189 (7%)
Query: 529 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 588
+C E P E G+ + G + V YQC PGY+ +GS + CQ + W + P
Sbjct: 2203 SCGEPPKVENGFLEHTTGRIFESEV-RYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVP 2261
Query: 589 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV- 647
+ C P I NG + F VGS VQ+ C GY L G + TC + KW+ +
Sbjct: 2262 LDCGKPPPIQNGFMKGEN--FEVGSKVQFFCNEGYELVGDSSWTCQK----SGKWNKKSN 2315
Query: 648 PKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 707
PKC C P + EN Q + K + F C EG L G + C+P QW
Sbjct: 2316 PKC--MPAKCPEPPLLEN--QLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPS--QQW 2369
Query: 708 TSQPPLCKV 716
P+CK+
Sbjct: 2370 NDSFPVCKI 2378
Score = 85.1 bits (209), Expect = 2e-16
Identities = 65/225 (28%), Positives = 93/225 (41%), Gaps = 51/225 (22%)
Query: 530 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM 589
CP L RTAS DL G+ + C+PG++L+G+ + C W+ P C++I
Sbjct: 1631 CPRLGGSVPHLRTASE-DLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERI- 1688
Query: 590 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 649
+C P + NG +A D F GS V Y+C GY L G + + C T W+ P
Sbjct: 1689 SCGVPPPLENGFHSADD--FYAGSTVTYQCNNGYYLLGDSRMFC----TDNGSWNGVSPS 1742
Query: 650 C-----------ALKYEPCLN----------------------------PGVPENGYQTL 670
C ++ CLN PG PENG+ +
Sbjct: 1743 CLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSS- 1801
Query: 671 YKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 715
Y G + F C EG++L+G ITC+ +W P CK
Sbjct: 1802 -GEIYTVGAEVTFSCQEGYQLMGVTKITCL--ESGEWNHLIPYCK 1843
Score = 84.3 bits (207), Expect = 4e-16
Identities = 66/188 (35%), Positives = 81/188 (43%), Gaps = 16/188 (8%)
Query: 529 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 588
+C + PE G+ S + + YQCEPGYEL G+ CQ + WS C K
Sbjct: 3240 SCGKPESPEHGFVVGSKYTF--ESTIIYQCEPGYELEGNRERVCQENRQWSGGVAIC-KE 3296
Query: 589 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 648
C P E NG A G +V Y C GYSLEG + C T WS VP
Sbjct: 3297 TRCETPLEFLNG--KADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGT----WSHPVP 3350
Query: 649 KCALKYEPCLNPGV-PENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 707
C K PC P V PEN L + + +++ C EGF L G ITC P W
Sbjct: 3351 LC--KPNPCPVPFVIPENA--LLSEKEFYVDQNVSIKCREGFLLQGHGIITCNP--DETW 3404
Query: 708 TSQPPLCK 715
T C+
Sbjct: 3405 TQTSAKCE 3412
Score = 80.1 bits (196), Expect = 8e-15
Identities = 56/209 (26%), Positives = 95/209 (45%), Gaps = 17/209 (8%)
Query: 530 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM 589
C E P G+ + S+ G ++ Y C G+ + G TC+ WS+ P C +
Sbjct: 2146 CGEPPSIMNGYASGSNYSF--GAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPV- 2202
Query: 590 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 649
+C +P ++ NG G S V+Y+C PGY G+ + C + W P
Sbjct: 2203 SCGEPPKVENGF-LEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQA----NRHWHSESPL 2257
Query: 650 CALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTS 709
+ + C P +NG+ + +++ G ++FFC EG+EL+G+ + TC +W
Sbjct: 2258 MCVPLD-CGKPPPIQNGF--MKGENFEVGSKVQFFCNEGYELVGDSSWTCQKS--GKWNK 2312
Query: 710 QP-PLC---KVAYEELLDNRKLEVTQTTD 734
+ P C K LL+N+ + TT+
Sbjct: 2313 KSNPKCMPAKCPEPPLLENQLVLKELTTE 2341
Score = 78.6 bits (192), Expect = 2e-14
Identities = 50/164 (30%), Positives = 73/164 (44%), Gaps = 13/164 (7%)
Query: 552 TVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPV 611
+ L Y+C+PGY L G++ TCQ D +W P C + C+ P ANG + F
Sbjct: 2795 STLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPV-DCSSPPVSANGQVRGDEYTFQ- 2852
Query: 612 GSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLY 671
++Y C G+ LEGA C + + WS P C C P NG
Sbjct: 2853 -KEIEYTCNEGFLLEGARSRVCLANGS----WSGATPDCV--PVRCATPPQLANGVTEGL 2905
Query: 672 KHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 715
+ + + + F C+EG+ L G +TC W ++ PLCK
Sbjct: 2906 DYGFM--KEVTFHCHEGYILHGAPKLTC--QSDGNWDAEIPLCK 2945
Score = 74.7 bits (182), Expect = 3e-13
Identities = 49/164 (29%), Positives = 76/164 (46%), Gaps = 13/164 (7%)
Query: 551 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 610
G+ +TY+C GY L G +C + SWS +PP C+ + C+ P I NG S G
Sbjct: 1866 GSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPV-KCSSPENINNGKYILS--GLT 1922
Query: 611 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTL 670
S Y C GYSL+G +++ C T + W P C L + C P ++ T
Sbjct: 1923 YLSTASYSCDTGYSLQGPSIIEC----TASGIWDRAPPACHLVF--CGEPPAIKDAVIT- 1975
Query: 671 YKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 714
+++ ++ + C EG+ L G TI C+ +W+ C
Sbjct: 1976 -GNNFTFRNTVTYTCKEGYTLAGLDTIECLA--DGKWSRSDQQC 2016
Score = 72.0 bits (175), Expect = 2e-12
Identities = 52/170 (30%), Positives = 72/170 (42%), Gaps = 17/170 (10%)
Query: 551 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 610
G +T+ C+ GY+L+G +TC W+ P C K ++C P NG + F
Sbjct: 1808 GAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYC-KAVSCGKPAIPENG--CIEELAFT 1864
Query: 611 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEP--CLNPGVPENGYQ 668
GS V YRC GY+L G +C + + WS P C EP C +P NG
Sbjct: 1865 FGSKVTYRCNKGYTLAGDKESSCLANSS----WSHSPPVC----EPVKCSSPENINNGKY 1916
Query: 669 TLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAY 718
L Y + S + C G+ L G I C W PP C + +
Sbjct: 1917 ILSGLTYLSTAS--YSCDTGYSLQGPSIIECTAS--GIWDRAPPACHLVF 1962
Score = 72.0 bits (175), Expect = 2e-12
Identities = 51/163 (31%), Positives = 71/163 (43%), Gaps = 12/163 (7%)
Query: 553 VLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVG 612
V+T+ C+ G+ L G +L C W+ + P C KI+ C P I+ G S A G
Sbjct: 2344 VVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVC-KIVLCTPPPLISFGVPIPSSA-LHFG 2401
Query: 613 SHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYK 672
S V+Y C+ G+ L G + C T WS +P+C C P NG +
Sbjct: 2402 STVKYSCVGGFFLRGNSTTLCQPDGT----WSSPLPECV--PVECPQPEEIPNGIIDVQG 2455
Query: 673 HHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 715
Y + + + C GFEL+G T C G W P CK
Sbjct: 2456 LAYLS--TALYTCKPGFELVGNTTTLC--GENGHWLGGKPTCK 2494
Score = 70.9 bits (172), Expect = 5e-12
Identities = 83/357 (23%), Positives = 132/357 (36%), Gaps = 42/357 (11%)
Query: 373 ATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQ 431
A++SC GY+L+ P + IEC W+ PAC + CG + V+ ++
Sbjct: 1927 ASYSCDTGYSLQGP---SIIECT--ASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTF 1981
Query: 432 SYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRL 491
+ C G + I + R D P + P+ RL
Sbjct: 1982 RNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPP---IVDHASPETAHRL 2038
Query: 492 --------------LSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPE 537
L+ L Q PP + HF E P + + L
Sbjct: 2039 FGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSIL---- 2094
Query: 538 WGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI-MTCADPGE 596
+ S G+V++++C G+ L S + C W+ +P + Q I + C +P
Sbjct: 2095 ---ESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPS 2151
Query: 597 IANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEP 656
I NG+ AS + + G+ V Y C G+ ++G TC T +WS +P C
Sbjct: 2152 IMNGY--ASGSNYSFGAMVAYSCNKGFYIKGEKKSTC----EATGQWSSPIPTC--HPVS 2203
Query: 657 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 713
C P ENG+ E +R+ C G++ +G C W S+ PL
Sbjct: 2204 CGEPPKVENGFLEHTTGRIFESE-VRYQCNPGYKSVGSPVFVCQANR--HWHSESPL 2257
Score = 69.7 bits (169), Expect = 1e-11
Identities = 50/168 (29%), Positives = 66/168 (39%), Gaps = 13/168 (7%)
Query: 551 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 610
G+ + Y C G+ L G+ CQ D +WS+ P C + C P EI NG G
Sbjct: 2401 GSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPV-ECPQPEEIPNG--IIDVQGLA 2457
Query: 611 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTL 670
S Y C PG+ L G C W P C K CL P NG +
Sbjct: 2458 YLSTALYTCKPGFELVGNTTTLCGENG----HWLGGKPTC--KAIECLKPKEILNGKFSY 2511
Query: 671 YKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAY 718
HY G+++ + C GF L G +TC+ W P C +
Sbjct: 2512 TDLHY--GQTVTYSCNRGFRLEGPSALTCL--ETGDWDVDAPSCNAIH 2555
Score = 68.9 bits (167), Expect = 2e-11
Identities = 96/406 (23%), Positives = 145/406 (35%), Gaps = 100/406 (24%)
Query: 372 LATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQ 431
+ TFSC G+ L+ P + ++C+ + WND+ P CK + + P + P
Sbjct: 2344 VVTFSCKEGHVLQGP---SVLKCLPSQQ--WNDSFPVCKIVL---CTPPPLISFGVPIPS 2395
Query: 432 SY-----SPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQ---LR 483
S + CV G ++ G+ TL DG + L + +
Sbjct: 2396 SALHFGSTVKYSCVGGFFLR----------------GNSTTLCQPDGTWSSPLPECVPVE 2439
Query: 484 GPQPRRRLLSSGPDL-------TLQFQAPPGPPNPG-----LGQ-GFVLHFKEVPRNDTC 530
PQP + + D+ T + PG G G+ G L K + C
Sbjct: 2440 CPQPEE-IPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIEC 2498
Query: 531 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMT 590
L P E S+ DL G +TY C G+ L G LTC W P+C I
Sbjct: 2499 --LKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAI-H 2555
Query: 591 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 650
C P I NG +D + G+ + Y C PG+ + G AM TC ++G WS +P C
Sbjct: 2556 CDSPQPIENGFVEGAD--YSYGAIIIYSCFPGFQVAGHAMQTC--EESG---WSSSIPTC 2608
Query: 651 A------------------------------LKYEPCLNPGVP----------ENGYQTL 670
+ P + P P EN ++
Sbjct: 2609 MPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESP 2668
Query: 671 YKH--HYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 714
H ++ G + + C G+EL+G + C W P C
Sbjct: 2669 ATHSSNFLYGTMVSYTCNPGYELLGNPVLIC--QEDGTWNGSAPSC 2712
Score = 68.6 bits (166), Expect = 2e-11
Identities = 128/608 (21%), Positives = 224/608 (36%), Gaps = 95/608 (15%)
Query: 149 GEEETTTTIITTTTVTTTVTSPAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQL 208
G++E++ ++ + + V P + C P +G ++ L TA++ CD+GY L
Sbjct: 1881 GDKESSCLANSSWSHSPPVCEP---VKCSSPENINNGKYILSGLTYLSTASYSCDTGYSL 1937
Query: 209 QGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVI-- 266
QG + C W+ P+C H G + + G N T R +
Sbjct: 1938 QGPSIIECT--ASGIWDRAPPAC--------HLVFCGEPPAIKDAVITGNNFTFRNTVTY 1987
Query: 267 EAAEGRRLHLHFERVSLDEDN---DRLMVRSGGSPLS-----PVIYDSDMDDVPERGLIS 318
EG L LD D RS L+ P I D + R L
Sbjct: 1988 TCKEGYTL------AGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHR-LFG 2040
Query: 319 DAQSLYVELLSETPANPLLLS------LRFEAFEEDRCFA------PFLAHGNV-TTTDP 365
D Y N LL + E + RC A P +++ + + +
Sbjct: 2041 DIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKA 2100
Query: 366 EYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM---CGGELSEPAG 422
++ G++ +F C+ G+ L IEC+ + WN + + + + CG S G
Sbjct: 2101 KFAAGSVVSFKCMEGFVLNTSA---KIECMRGGQ--WNPSPMSIQCIPVRCGEPPSIMNG 2155
Query: 423 VVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQL 482
++ C G +++ EK+ + + P+ ++
Sbjct: 2156 YASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEA----------TGQWSSPIPTCHPVSCG 2205
Query: 483 RGPQPRRRLLSSGP----DLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT--------C 530
P+ L + +++Q PG + G FV +++ C
Sbjct: 2206 EPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVG-SPVFVCQANRHWHSESPLMCVPLDC 2264
Query: 531 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWS-AAPPACQKIM 589
+ PP + G+ + ++ G+ + + C GYEL+G TCQ W+ + P C
Sbjct: 2265 GKPPPIQNGFMKGENFEV--GSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMP-A 2321
Query: 590 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 649
C +P + N + VG V + C G+ L+G ++L C + +W+D P
Sbjct: 2322 KCPEPPLLEN-QLVLKELTTEVGV-VTFSCKEGHVLQGPSVLKCLP----SQQWNDSFPV 2375
Query: 650 CALKY---EPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ 706
C + P ++ GVP + G ++++ C GF L G T C P
Sbjct: 2376 CKIVLCTPPPLISFGVP------IPSSALHFGSTVKYSCVGGFFLRGNSTTLCQP--DGT 2427
Query: 707 WTSQPPLC 714
W+S P C
Sbjct: 2428 WSSPLPEC 2435
Score = 67.8 bits (164), Expect = 4e-11
Identities = 50/165 (30%), Positives = 72/165 (43%), Gaps = 13/165 (7%)
Query: 551 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 610
G + Y C GY L G C + +WS P C K C P I + S+ F
Sbjct: 3318 GPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLC-KPNPCPVPFVIPE-NALLSEKEFY 3375
Query: 611 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTL 670
V +V +C G+ L+G ++TC +T W+ KC + C P EN
Sbjct: 3376 VDQNVSIKCREGFLLQGHGIITCNPDET----WTQTSAKC--EKISCGPPAHVENAIARG 3429
Query: 671 YKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 715
HYQ G+ + + CY G+ L G + C+ WTS PP+C+
Sbjct: 3430 V--HYQYGDMITYSCYSGYMLEGFLRSVCLEN--GTWTS-PPICR 3469
Score = 61.2 bits (147), Expect = 4e-09
Identities = 36/125 (28%), Positives = 57/125 (45%), Gaps = 5/125 (4%)
Query: 530 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM 589
CP L PPE G+ + + +C PG++L+GS I+ C + WS + C ++
Sbjct: 378 CPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYC-RVR 436
Query: 590 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 649
TC + +GH + S + C GY LEG+ LTC G +W P+
Sbjct: 437 TCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC----QGNSQWDGPEPR 492
Query: 650 CALKY 654
C ++
Sbjct: 493 CVERH 497
Score = 57.0 bits (136), Expect = 7e-08
Identities = 42/182 (23%), Positives = 74/182 (40%), Gaps = 14/182 (7%)
Query: 534 PPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD 593
PP + + I G + YQC PGY+L G+ C + SWS + P+C C+
Sbjct: 2951 PPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLP-CRCST 3009
Query: 594 PGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALK 653
P + T + F G + +C G+ L G + +TC +WS P C +
Sbjct: 3010 P---VIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITC----EADGQWSSGFPHC--E 3060
Query: 654 YEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 713
+ C + + N + + + + + C G+ + G + C W+ P+
Sbjct: 3061 HTSCGSLPMIPNAF--ISETSSWKENVITYSCRSGYVIQGSSDLICT--EKGVWSQPYPV 3116
Query: 714 CK 715
C+
Sbjct: 3117 CE 3118
Score = 56.2 bits (134), Expect = 1e-07
Identities = 24/59 (40%), Positives = 35/59 (59%), Gaps = 2/59 (3%)
Query: 174 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232
+SCG PP +G S D + G T T+ C++GY L G+ + C + SWNG +PSC+
Sbjct: 1688 ISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTD--NGSWNGVSPSCL 1744
Score = 55.5 bits (132), Expect = 2e-07
Identities = 32/109 (29%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 554 LTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGS 613
++ +C G+ L G I+TC D +W+ C+KI +C P + N A + G
Sbjct: 3380 VSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKI-SCGPPAHVENA--IARGVHYQYGD 3436
Query: 614 HVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGV 662
+ Y C GY LEG C T T S + + ++ PC N G+
Sbjct: 3437 MITYSCYSGYMLEGFLRSVCLENGTWT---SPPICRAVCRF-PCQNGGI 3481
Score = 54.3 bits (129), Expect = 4e-07
Identities = 53/187 (28%), Positives = 71/187 (37%), Gaps = 20/187 (10%)
Query: 534 PPPEWGWRTASHGDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPP----ACQKI 588
P PE HGD ++ C GY G +I CQ D +W PP +C +
Sbjct: 3182 PLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWE--PPFSDESCSPV 3239
Query: 589 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 648
+C P +G S F S + Y+C PGY LEG C +WS V
Sbjct: 3240 -SCGKPESPEHGFVVGSKYTFE--STIIYQCEPGYELEGNRERVCQE----NRQWSGGVA 3292
Query: 649 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 708
C K C P NG + + G ++ + C G+ L G C W+
Sbjct: 3293 IC--KETRCETPLEFLNGKADI--ENRTTGPNVVYSCNRGYSLEGPSEAHCTEN--GTWS 3346
Query: 709 SQPPLCK 715
PLCK
Sbjct: 3347 HPVPLCK 3353
Score = 53.1 bits (126), Expect = 1e-06
Identities = 37/128 (28%), Positives = 51/128 (39%), Gaps = 7/128 (5%)
Query: 529 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC--Q 586
TCP L P+ G + S +++ T C+ GY L GSD LTCQ + W P C +
Sbjct: 437 TCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVER 496
Query: 587 KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGA-AMLTCYSRDTGTPKWSD 645
T P ++ G+ C G+ L G ML C T + KW+
Sbjct: 497 HCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRC----TTSGKWNV 552
Query: 646 RVPKCALK 653
V K
Sbjct: 553 GVQAAVCK 560
Score = 53.1 bits (126), Expect = 1e-06
Identities = 43/160 (26%), Positives = 63/160 (39%), Gaps = 12/160 (7%)
Query: 557 QCEPGYEL-LGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHV 615
+C GY + +D TCQ D W +C C P I H F V V
Sbjct: 3147 RCLEGYTMDTDTDTFTCQKDGRWFPERISCSP-KKCPLPENIT--HILVHGDDFSVNRQV 3203
Query: 616 QYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHY 675
C GY+ EG + C T P +SD + C P PE+G+ K+ +
Sbjct: 3204 SVSCAEGYTFEGVNISVCQLDGTWEPPFSDE----SCSPVSCGKPESPEHGFVVGSKYTF 3259
Query: 676 QAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 715
++ ++ + C G+EL G C QW+ +CK
Sbjct: 3260 ES--TIIYQCEPGYELEGNRERVCQENR--QWSGGVAICK 3295
Score = 52.4 bits (124), Expect = 2e-06
Identities = 40/149 (26%), Positives = 60/149 (40%), Gaps = 14/149 (9%)
Query: 553 VLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVG 612
V+TY C GY + GS L C WS P C+ ++C P +AN A+
Sbjct: 3085 VITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEP-LSCGSPPSVANA--VATGEAHTYE 3141
Query: 613 SHVQYRCLPGYSLE-GAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPEN-GYQTL 670
S V+ RCL GY+++ TC +W C+ K P +PEN + +
Sbjct: 3142 SEVKLRCLEGYTMDTDTDTFTCQK----DGRWFPERISCSPKKCP-----LPENITHILV 3192
Query: 671 YKHHYQAGESLRFFCYEGFELIGEVTITC 699
+ + + C EG+ G C
Sbjct: 3193 HGDDFSVNRQVSVSCAEGYTFEGVNISVC 3221
Score = 43.5 bits (101), Expect = 8e-04
Identities = 25/69 (36%), Positives = 35/69 (50%), Gaps = 8/69 (11%)
Query: 650 CALKYEPCLNPGVPENGY--QTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 707
C L + P L P PENGY Q +H+ A +R C+ GF+L+G I C+P W
Sbjct: 373 CELVHCPALKP--PENGYFIQNTCNNHFNAACGVR--CHPGFDLVGSSIILCLPN--GLW 426
Query: 708 TSQPPLCKV 716
+ C+V
Sbjct: 427 SGSESYCRV 435
Score = 42.4 bits (98), Expect = 0.002
Identities = 21/59 (35%), Positives = 31/59 (52%), Gaps = 2/59 (3%)
Query: 174 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232
++CG P AHG + GG + C GY+L G + CL + SW+G +PSC+
Sbjct: 2947 VNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCL--SNGSWSGSSPSCL 3003
Score = 41.6 bits (96), Expect = 0.003
Identities = 24/64 (37%), Positives = 27/64 (42%), Gaps = 3/64 (4%)
Query: 174 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMA 233
+ C P P +G S G TF C GYQL G + CL WN P C A
Sbjct: 1787 IKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLES--GEWNHLIPYCKA 1844
Query: 234 -SCG 236
SCG
Sbjct: 1845 VSCG 1848
Score = 40.0 bits (92), Expect = 0.009
Identities = 63/257 (24%), Positives = 86/257 (33%), Gaps = 77/257 (29%)
Query: 191 DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC-MASCG------GTIHNA- 242
DL PG CD G+QL G CLN + W P C SCG H+A
Sbjct: 1647 DLKPGSKVNLFCDPGFQLVGNPVQYCLN--QGQWTQPLPHCERISCGVPPPLENGFHSAD 1704
Query: 243 -----------------TLG--RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSL 283
LG R+ + G G + +C V E A G H +++
Sbjct: 1705 DFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNV 1764
Query: 284 DEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFE 343
D GS + + P G D ++ + + P NP
Sbjct: 1765 D-----------GSYICSCV-------PPYTG---DGKNCAEPIKCKAPGNP-------- 1795
Query: 344 AFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWN 403
N ++ Y GA TFSC GY L I C++ E WN
Sbjct: 1796 --------------ENGHSSGEIYTVGAEVTFSCQEGYQLM---GVTKITCLESGE--WN 1836
Query: 404 DTEPACKAMCGGELSEP 420
P CKA+ G+ + P
Sbjct: 1837 HLIPYCKAVSCGKPAIP 1853
Score = 39.3 bits (90), Expect = 0.015
Identities = 19/58 (32%), Positives = 27/58 (46%), Gaps = 2/58 (3%)
Query: 174 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 231
+SCG P P +G + G T+ C+ GY L G++ CL SW+ P C
Sbjct: 1845 VSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCL--ANSSWSHSPPVC 1900
Score = 39.3 bits (90), Expect = 0.015
Identities = 36/129 (27%), Positives = 50/129 (38%), Gaps = 28/129 (21%)
Query: 133 PPPSPASPGPPLGPEGGEEETTTTIITTTTVT-------TTVTSPAYL------------ 173
P P S G P E G E TT I + V +V SP ++
Sbjct: 2197 PTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESP 2256
Query: 174 -----LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGET 228
L CG PP +G + + G F C+ GY+L G+ + C + WN ++
Sbjct: 2257 LMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGK--WNKKS 2314
Query: 229 -PSCM-ASC 235
P CM A C
Sbjct: 2315 NPKCMPAKC 2323
Score = 38.5 bits (88), Expect = 0.025
Identities = 18/58 (31%), Positives = 27/58 (46%), Gaps = 2/58 (3%)
Query: 174 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 231
+SCG P P HG V + T + C+ GY+L+G +C + W+G C
Sbjct: 3239 VSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQ--WSGGVAIC 3294
Score = 37.0 bits (84), Expect = 0.073
Identities = 18/60 (30%), Positives = 31/60 (51%), Gaps = 4/60 (6%)
Query: 175 SCGFPPRPAHGDVSVT--DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232
+C +P HG +S + ++ T CD GY+L+G + L C ++ W+G P C+
Sbjct: 437 TCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQ--WDGPEPRCV 494
Score = 36.6 bits (83), Expect = 0.096
Identities = 22/63 (34%), Positives = 28/63 (44%), Gaps = 3/63 (4%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC-MA 233
SCG P + +S T T+ C SGY +QG LIC + W+ P C
Sbjct: 3063 SCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTE--KGVWSQPYPVCEPL 3120
Query: 234 SCG 236
SCG
Sbjct: 3121 SCG 3123
Score = 33.5 bits (75), Expect = 0.81
Identities = 23/72 (31%), Positives = 30/72 (41%), Gaps = 5/72 (6%)
Query: 165 TTVTSPAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPS 223
T ++ +SCG P + G T+ C SGY L+G +CL NGT
Sbjct: 3405 TQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGT--- 3461
Query: 224 WNGETPSCMASC 235
W P C A C
Sbjct: 3462 WT-SPPICRAVC 3472
>gi|168693643 decay accelerating factor for complement isoform 2
precursor [Homo sapiens]
Length = 440
Score = 97.1 bits (240), Expect = 6e-20
Identities = 60/168 (35%), Positives = 85/168 (50%), Gaps = 8/168 (4%)
Query: 551 GTVLTYQCEPGY--ELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAG 608
GTV+ Y+C PGY E S LTC +L WS A C+K +C +PGEI NG G
Sbjct: 122 GTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKK-KSCPNPGEIRNGQIDVP-GG 179
Query: 609 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 668
G+ + + C GY L G+ C + +WSD +P+C Y C P +NG
Sbjct: 180 ILFGATISFSCNTGYKLFGSTSSFCLISGSSV-QWSDPLPECREIY--CPAPPQIDNGII 236
Query: 669 TLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 715
+ HY +S+ + C +GF +IGE +I C V +W+ PP C+
Sbjct: 237 QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECR 284
Score = 67.0 bits (162), Expect = 7e-11
Identities = 53/175 (30%), Positives = 75/175 (42%), Gaps = 17/175 (9%)
Query: 552 TVLTYQCEPGYELLGS--DILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTA---SD 606
TV+TY+CE + + D + C WS C + +C P + + +
Sbjct: 59 TVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNR--SCEVPTRLNSASLKQPYITQ 116
Query: 607 AGFPVGSHVQYRCLPGYSLEG--AAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 664
FPVG+ V+Y C PGY E + LTC KWS V C K + C NPG
Sbjct: 117 NYFPVGTVVEYECRPGYRREPSLSPKLTCLQ----NLKWSTAVEFC--KKKSCPNPGEIR 170
Query: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKVAY 718
NG Q G ++ F C G++L G + C + G QW+ P C+ Y
Sbjct: 171 NG-QIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIY 224
Score = 48.5 bits (114), Expect = 2e-05
Identities = 31/109 (28%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 546 GDLIRGTVLTYQCEPGYELLGSDILTC---QWDLSWSAAPPACQKIMTCADPGEIANGHR 602
G ++ G +++ C GY+L GS C + WS P C++I C P +I NG
Sbjct: 178 GGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIY-CPAPPQIDNGII 236
Query: 603 TASDAGFPVGSHVQYRCLPGYSLEGAAMLTC-YSRDTGTPKWSDRVPKC 650
+ V Y C G+++ G + C + D G +WS P+C
Sbjct: 237 QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEG--EWSGPPPEC 283
Score = 36.2 bits (82), Expect = 0.13
Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 10/63 (15%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGG-----TATFHCDSGYQLQGEETLICL-NGTRPSWNGET 228
SC P +G + V PGG T +F C++GY+L G + CL +G+ W+
Sbjct: 162 SCPNPGEIRNGQIDV----PGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217
Query: 229 PSC 231
P C
Sbjct: 218 PEC 220
>gi|10835143 decay accelerating factor for complement isoform 1
preproprotein [Homo sapiens]
Length = 381
Score = 97.1 bits (240), Expect = 6e-20
Identities = 60/168 (35%), Positives = 85/168 (50%), Gaps = 8/168 (4%)
Query: 551 GTVLTYQCEPGY--ELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAG 608
GTV+ Y+C PGY E S LTC +L WS A C+K +C +PGEI NG G
Sbjct: 122 GTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKK-KSCPNPGEIRNGQIDVP-GG 179
Query: 609 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 668
G+ + + C GY L G+ C + +WSD +P+C Y C P +NG
Sbjct: 180 ILFGATISFSCNTGYKLFGSTSSFCLISGSSV-QWSDPLPECREIY--CPAPPQIDNGII 236
Query: 669 TLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 715
+ HY +S+ + C +GF +IGE +I C V +W+ PP C+
Sbjct: 237 QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECR 284
Score = 67.0 bits (162), Expect = 7e-11
Identities = 53/175 (30%), Positives = 75/175 (42%), Gaps = 17/175 (9%)
Query: 552 TVLTYQCEPGYELLGS--DILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTA---SD 606
TV+TY+CE + + D + C WS C + +C P + + +
Sbjct: 59 TVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNR--SCEVPTRLNSASLKQPYITQ 116
Query: 607 AGFPVGSHVQYRCLPGYSLEG--AAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 664
FPVG+ V+Y C PGY E + LTC KWS V C K + C NPG
Sbjct: 117 NYFPVGTVVEYECRPGYRREPSLSPKLTCLQ----NLKWSTAVEFC--KKKSCPNPGEIR 170
Query: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKVAY 718
NG Q G ++ F C G++L G + C + G QW+ P C+ Y
Sbjct: 171 NG-QIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIY 224
Score = 48.5 bits (114), Expect = 2e-05
Identities = 31/109 (28%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 546 GDLIRGTVLTYQCEPGYELLGSDILTC---QWDLSWSAAPPACQKIMTCADPGEIANGHR 602
G ++ G +++ C GY+L GS C + WS P C++I C P +I NG
Sbjct: 178 GGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIY-CPAPPQIDNGII 236
Query: 603 TASDAGFPVGSHVQYRCLPGYSLEGAAMLTC-YSRDTGTPKWSDRVPKC 650
+ V Y C G+++ G + C + D G +WS P+C
Sbjct: 237 QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEG--EWSGPPPEC 283
Score = 36.2 bits (82), Expect = 0.13
Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 10/63 (15%)
Query: 175 SCGFPPRPAHGDVSVTDLHPGG-----TATFHCDSGYQLQGEETLICL-NGTRPSWNGET 228
SC P +G + V PGG T +F C++GY+L G + CL +G+ W+
Sbjct: 162 SCPNPGEIRNGQIDV----PGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217
Query: 229 PSC 231
P C
Sbjct: 218 PEC 220
>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
sapiens]
Length = 569
Score = 91.7 bits (226), Expect = 3e-18
Identities = 91/359 (25%), Positives = 141/359 (39%), Gaps = 26/359 (7%)
Query: 375 FSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYS 434
+SC GY L G +A + W++ P C + G A + + +
Sbjct: 121 YSCPKGYRLI--GSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFH 178
Query: 435 PGQ----DCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRR 490
G C G ++ ++ + I + D + ++ G P + + P
Sbjct: 179 YGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENG 238
Query: 491 LL-SSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELP--------PPE--WG 539
+L S L + PG G H K N PELP PP+
Sbjct: 239 ILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHA 298
Query: 540 WRTASHGDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEI 597
RT D G + Y CEPGY+L GS L C WS A P C+ + +C D G++
Sbjct: 299 ERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCE-VKSCDDFLGQL 357
Query: 598 ANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPC 657
NGH +G+ V + C G+ L+G++ C + W+ VP C K C
Sbjct: 358 PNGH-VLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES-LWNSSVPVCERK--SC 413
Query: 658 LNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCV-PGHPSQWTSQPPLCK 715
P VP NG + G + + C G LIG + C+ G+ + W+ +PP+C+
Sbjct: 414 ETPPVPVNGMVHVIT-DIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQ 471
Score = 70.1 bits (170), Expect = 8e-12
Identities = 121/537 (22%), Positives = 187/537 (34%), Gaps = 111/537 (20%)
Query: 157 IITTTTVTTTVTSPAYLLSCGFPPRPAHGDVSVT-DLHPGGTATFHCDSGYQLQGEETLI 215
I +V T+ SC PP P +G V D+ + C GY+L G +
Sbjct: 77 ICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSAT 136
Query: 216 CL-NGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRL 274
C+ +G W+ +TP C RI+ P + T R
Sbjct: 137 CIISGNTVIWDNKTPVC-------------DRIICGLPPTIANGDFTSI--------SRE 175
Query: 275 HLHFERVSLDEDNDRLMVRSGGSPL-----SPVIYDSDMDDVPERGLISDAQSLYVELLS 329
+ H+ V N + S G + P IY + DD + G+ S
Sbjct: 176 YFHYGSVVTYHCN----LGSRGKKVFELVGEPSIYCTSKDD--QVGIWSG---------- 219
Query: 330 ETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGP 388
PA ++ ++C P + +G + + + + + F C PG+ ++ P
Sbjct: 220 --PAPQCIIP--------NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGP-- 267
Query: 389 PNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQ----SYSPGQDCVWGVH 444
+ ++C + W P+C +C +P VL + Q ++SPGQ+ +
Sbjct: 268 -SHVKCQALNK--WEPELPSCSRVC-----QPPPDVLHAERTQRDKDNFSPGQEVFYSCE 319
Query: 445 VQEEKRILLQVEILNVREGDMLTL-----------FDGDGPSARVLAQLRGPQPRRRLLS 493
+ R + +GD F G P+ VL L L
Sbjct: 320 PGYDLRGSTYLHC--TPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLN--------LQ 369
Query: 494 SGPDLTLQFQAPPGPPNPGLGQGF-VLHFKEVPRNDTCP-------ELPPPEWGWRTASH 545
G + F G G + VL E N + P E PP
Sbjct: 370 LGAKV--DFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVI 427
Query: 546 GDLIRGTVLTYQCEPGYELLGSDILTCQWD---LSWSAAPPACQKIMTCADPGEIANGHR 602
D+ G+ + Y C G+ L+G C WS PP CQ+I C +P I NG
Sbjct: 428 TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIF-CPNPPAILNGRH 486
Query: 603 TASDAG-FPVGSHVQYRCLP------GYSLEGAAMLTCYSRDTGTPKWSDRVPKCAL 652
T + G P G V Y C P ++L G + + S G WS P+C L
Sbjct: 487 TGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
Score = 67.0 bits (162), Expect = 7e-11
Identities = 60/220 (27%), Positives = 84/220 (38%), Gaps = 15/220 (6%)
Query: 522 KEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD---LSW 578
K+ + +C P P G R + Y C GY L+GS TC + W
Sbjct: 88 KDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQI-KYSCPKGYRLIGSSSATCIISGNTVIW 146
Query: 579 SAAPPACQKIMTCADPGEIANGHRTA-SDAGFPVGSHVQYRCLPG------YSLEGAAML 631
P C +I+ C P IANG T+ S F GS V Y C G + L G +
Sbjct: 147 DNKTPVCDRII-CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSI 205
Query: 632 TCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFEL 691
C S+D WS P+C + C P V + + + E + F C GF +
Sbjct: 206 YCTSKDDQVGIWSGPAPQCIIP-NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGM 264
Query: 692 IGEVTITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEVTQ 731
G + C ++W + P C + D E TQ
Sbjct: 265 KGPSHVKCQA--LNKWEPELPSCSRVCQPPPDVLHAERTQ 302
Score = 63.9 bits (154), Expect = 6e-10
Identities = 47/173 (27%), Positives = 76/173 (43%), Gaps = 15/173 (8%)
Query: 551 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANG-HRTASDAGF 609
GT L Y+C PGY I+ C + W++A C++ +C +P + NG D F
Sbjct: 58 GTYLNYECRPGYSGRPFSII-CLKNSVWTSAKDKCKR-KSCRNPPDPVNGMAHVIKDIQF 115
Query: 610 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT 669
S ++Y C GY L G++ TC T W ++ P C + L P + + +
Sbjct: 116 --RSQIKYSCPKGYRLIGSSSATCII-SGNTVIWDNKTPVCD-RIICGLPPTIANGDFTS 171
Query: 670 LYKHHYQAGESLRFFCYEG------FELIGEVTITCV--PGHPSQWTSQPPLC 714
+ + ++ G + + C G FEL+GE +I C W+ P C
Sbjct: 172 ISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQC 224
Score = 58.9 bits (141), Expect = 2e-08
Identities = 34/110 (30%), Positives = 55/110 (50%), Gaps = 9/110 (8%)
Query: 606 DAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPEN 665
D FP+G+++ Y C PGYS +++ C W+ KC K + C NP P N
Sbjct: 52 DFEFPIGTYLNYECRPGYSGRPFSII-CLKNSV----WTSAKDKC--KRKSCRNPPDPVN 104
Query: 666 GYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLC 714
G + K Q +++ C +G+ LIG + TC + G+ W ++ P+C
Sbjct: 105 GMAHVIK-DIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVC 153
Score = 47.8 bits (112), Expect = 4e-05
Identities = 48/177 (27%), Positives = 68/177 (38%), Gaps = 38/177 (21%)
Query: 149 GEEETTTTIITTTTVTTTVTSPAYLLSCGFPPRPAHGD---VSVTDLHPGGTATFHCDSG 205
G T I T + T + CG PP A+GD +S H G T+HC+ G
Sbjct: 131 GSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLG 190
Query: 206 ------YQLQGEETLICLNGTRP--SWNGETPSCMASCGGTIHNATLGRIVSP------- 250
++L GE ++ C + W+G P C+ T N G +VS
Sbjct: 191 SRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSL 250
Query: 251 --------EPG-GAVGP-NLTC----RWVIEAAEGRRL------HLHFERVSLDEDN 287
+PG G GP ++ C +W E R+ LH ER D+DN
Sbjct: 251 NEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDN 307
>gi|157419154 selectin P precursor [Homo sapiens]
Length = 830
Score = 89.4 bits (220), Expect = 1e-17
Identities = 142/592 (23%), Positives = 215/592 (36%), Gaps = 110/592 (18%)
Query: 172 YLLSCGFPPRPAHGDVSVTDLHPGGT------ATFHCDSGYQLQGEETLICLNGTRPSWN 225
Y+ CG P H V + HP G +FHC GYQ+ G L CL W
Sbjct: 196 YVRECGELELPQH--VLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECL--ASGIWT 251
Query: 226 GETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDE 285
+ P C+A A + PE G N+TC LH + +
Sbjct: 252 NKPPQCLA--------AQCPPLKIPERG-----NMTC-------------LHSAKAFQHQ 285
Query: 286 DNDRLMVRSGGSPLSPVIYDSDMDDV--PERGLISDAQSLYVELLSETPANPLLLSLRFE 343
+ G + + P + V + Q ++E SE +
Sbjct: 286 SSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMD--------- 336
Query: 344 AFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWN 403
C P A + G+ F C PGY + + + C+D HW+
Sbjct: 337 ------CVHPLTA----------FAYGSSCKFECQPGYRVR---GLDMLRCID--SGHWS 375
Query: 404 DTEPACKAMCGGELSEP--AGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR 461
P C+A+ L P + SP +++ +C + E +L +I+
Sbjct: 376 APLPTCEAISCEPLESPVHGSMDCSPSL-RAFQYDTNCSFRC---AEGFMLRGADIVRC- 430
Query: 462 EGDMLTLFDGDGPSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPG-PPNPGL---GQG 516
D L + P + L P P R+ S P ++Q+ N GL G
Sbjct: 431 --DNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGAS 488
Query: 517 FVL-----HFKEVP---RNDTCPELPPPEWGWRTASH--GDLIRGTVLTYQCEPGYELLG 566
+ ++ VP + C L P+ G T G + + C+ GY L G
Sbjct: 489 VLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSG 548
Query: 567 SDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD--AGFPVGSHVQYRCLPGYS 624
+ L C W+ +PP C+ I C + G SD F VGS + C G+
Sbjct: 549 PERLDCTRSGRWTDSPPMCEAI-KCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFK 607
Query: 625 LEGAAMLTCYSRDTGTPKWSDRVPKC----ALKYEPCLNPGVPENGYQTLY-KHH---YQ 676
LEG + C T + +WS P C +L P + G T+Y +HH +
Sbjct: 608 LEGPNNVEC----TTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFG 663
Query: 677 AGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK-VAYEELLDNRKL 727
+ F C GF LIG+ T++C P QWT+ P C+ V EL N+ +
Sbjct: 664 FNTTCYFGCNAGFTLIGDSTLSCRPS--GQWTAVTPACRAVKCSELHVNKPI 713
Score = 59.3 bits (142), Expect = 1e-08
Identities = 52/198 (26%), Positives = 78/198 (39%), Gaps = 19/198 (9%)
Query: 530 CPELPPPEWGWRTAS--HGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQK 587
CPEL PE G S G+ G+ + C+ G++L G + + C WSA PP C+
Sbjct: 572 CPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKG 631
Query: 588 IMTCADPGEIANGHRTASD---------AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDT 638
I + PG T F + + C G++L G + L+C R +
Sbjct: 632 IASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSC--RPS 689
Query: 639 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTIT 698
G +W+ P C L+ P + ++ G F C EG L G
Sbjct: 690 G--QWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTA 747
Query: 699 CVP-GHPSQWTSQPPLCK 715
C GH W++ P C+
Sbjct: 748 CQENGH---WSTTVPTCQ 762
Score = 52.8 bits (125), Expect = 1e-06
Identities = 111/526 (21%), Positives = 179/526 (34%), Gaps = 105/526 (19%)
Query: 159 TTTTVTTTVTSPAYLLSCGFPPRPAHGDVSVTDLHP------GGTATFHCDSGYQLQGEE 212
T + V T + C P+ G + +HP G + F C GY+++G +
Sbjct: 307 TASGVWTAPAPVCKAVQCQHLEAPSEGTMDC--VHPLTAFAYGSSCKFECQPGYRVRGLD 364
Query: 213 TLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGR 272
L C++ W+ P+C A + + G + A + C + AEG
Sbjct: 365 MLRCIDSGH--WSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSF--RCAEGF 420
Query: 273 RLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSL----YVELL 328
L R + D L + +P+ + D+ VP ++ + Y +
Sbjct: 421 ML-----RGADIVRCDNLGQWTAPAPVCQALQCQDL-PVPNEARVNCSHPFGAFRYQSVC 474
Query: 329 SETPANPLLLSLRFEAFEEDRCFA-----------------PFLA--HGNVTTTDPEYRP 369
S T LLL +C A P L+ +G +T P
Sbjct: 475 SFTCNEGLLL----VGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSS 530
Query: 370 GALAT--FSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEP-AGVVLS 426
+T F C GY+L P ++C W D+ P C+A+ EL P G +
Sbjct: 531 SYKSTCQFICDEGYSL---SGPERLDCT--RSGRWTDSPPMCEAIKCPELFAPEQGSLDC 585
Query: 427 PDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQ 486
D ++ G C H + ++E N E + P+ + +A L P
Sbjct: 586 SDTRGEFNVGSTC----HFSCDNG--FKLEGPNNVECTTSGRWSATPPTCKGIASLPTPG 639
Query: 487 PRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHG 546
+ P PG G + H P +G+ T +
Sbjct: 640 VQ----------------CPALTTPGQGTMYCRHH-------------PGTFGFNTTCY- 669
Query: 547 DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD 606
+ C G+ L+G L+C+ W+A PAC+ + C++ S+
Sbjct: 670 ---------FGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAV-KCSELHVNKPIAMNCSN 719
Query: 607 --AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 650
F GS + CL G L G+A C WS VP C
Sbjct: 720 LWGNFSYGSICSFHCLEGQLLNGSAQTACQENG----HWSTTVPTC 761
Score = 46.6 bits (109), Expect = 9e-05
Identities = 87/420 (20%), Positives = 124/420 (29%), Gaps = 124/420 (29%)
Query: 182 PAHGDVSVTDLHPGGT------ATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASC 235
P + V HP G +F C+ G L G L CL +WN P C A
Sbjct: 452 PVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCL--ATGNWNSVPPECQAIP 509
Query: 236 GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSG 295
+ + G + +P G+ TC+++ + E SL RSG
Sbjct: 510 CTPLLSPQNGTMTCVQPLGSSSYKSTCQFICD-----------EGYSLSGPERLDCTRSG 558
Query: 296 GSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFL 355
SP + EA + FAP
Sbjct: 559 RWTDSPPMC--------------------------------------EAIKCPELFAPEQ 580
Query: 356 AHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM--- 412
+ + T E+ G+ FSC G+ LE PN +EC T W+ T P CK +
Sbjct: 581 GSLDCSDTRGEFNVGSTCHFSCDNGFKLE---GPNNVECT--TSGRWSATPPTCKGIASL 635
Query: 413 ------CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDML 466
C + G + P ++ C +G +
Sbjct: 636 PTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAG-------------------F 676
Query: 467 TLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPR 526
TL S R Q P R + LH + P
Sbjct: 677 TLIGDSTLSCRPSGQWTAVTPACRAVKCSE----------------------LHVNK-PI 713
Query: 527 NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 586
C L WG + G++ ++ C G L GS CQ + WS P CQ
Sbjct: 714 AMNCSNL----WG-------NFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762
>gi|27502417 CD46 antigen, complement regulatory protein isoform 10
precursor [Homo sapiens]
Length = 370
Score = 82.4 bits (202), Expect = 2e-15
Identities = 79/267 (29%), Positives = 116/267 (43%), Gaps = 35/267 (13%)
Query: 528 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 584
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 585 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 638
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 639 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 695
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 696 TITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEVTQTTDPSRQLEG--GNLALAILLPLG 753
TI C S T PP+ K K + + + EG +L + ++ +
Sbjct: 267 TIVC----DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIV 322
Query: 754 LVIVLGSGV-------YIYYTKLQGKS 773
+ IV+G V Y+ K +GK+
Sbjct: 323 IAIVVGVAVICVVPYRYLQRRKKKGKA 349
Score = 50.4 bits (119), Expect = 6e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 609 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 664
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 715
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 35.8 bits (81), Expect = 0.16
Identities = 20/71 (28%), Positives = 32/71 (45%), Gaps = 4/71 (5%)
Query: 197 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-ASCGGTIHNATLGRIVSPEPGGA 255
T F CD G+ L G +T++C + +W+ P C+ S T + P+P
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEEG 308
Query: 256 VGPNLTCRWVI 266
+ +L WVI
Sbjct: 309 ILDSLDV-WVI 318
Score = 34.7 bits (78), Expect = 0.36
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 200 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 231
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
>gi|27502419 CD46 antigen, complement regulatory protein isoform 11
precursor [Homo sapiens]
Length = 348
Score = 81.6 bits (200), Expect = 3e-15
Identities = 70/213 (32%), Positives = 95/213 (44%), Gaps = 28/213 (13%)
Query: 528 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 584
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 585 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 638
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 639 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 695
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 696 TITCVPGHPSQWTSQPPLCKVAY----EELLDN 724
TI C S W P C Y E +LD+
Sbjct: 267 TIVC--DSNSTWDPPVPKCLKGYPKPEEGILDS 297
Score = 50.4 bits (119), Expect = 6e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 609 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 664
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 715
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 34.7 bits (78), Expect = 0.36
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 200 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 231
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
Score = 34.7 bits (78), Expect = 0.36
Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 197 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232
T F CD G+ L G +T++C + +W+ P C+
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCL 284
>gi|27502427 CD46 antigen, complement regulatory protein isoform 12
precursor [Homo sapiens]
Length = 355
Score = 81.6 bits (200), Expect = 3e-15
Identities = 70/213 (32%), Positives = 95/213 (44%), Gaps = 28/213 (13%)
Query: 528 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 584
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 585 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 638
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 639 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 695
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 696 TITCVPGHPSQWTSQPPLCKVAY----EELLDN 724
TI C S W P C Y E +LD+
Sbjct: 267 TIVC--DSNSTWDPPVPKCLKGYPKPEEGILDS 297
Score = 50.4 bits (119), Expect = 6e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 609 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 664
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 715
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 34.7 bits (78), Expect = 0.36
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 200 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 231
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
Score = 34.7 bits (78), Expect = 0.36
Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 197 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232
T F CD G+ L G +T++C + +W+ P C+
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCL 284
>gi|27502415 CD46 antigen, complement regulatory protein isoform 9
precursor [Homo sapiens]
Length = 363
Score = 81.3 bits (199), Expect = 3e-15
Identities = 75/249 (30%), Positives = 109/249 (43%), Gaps = 28/249 (11%)
Query: 528 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 584
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 585 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 638
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 639 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 695
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 696 TITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEVTQTTDPSRQLEG--GNLALAILLPLG 753
TI C S T PP+ K K + + + EG +L + ++ +
Sbjct: 267 TIVC----DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIV 322
Query: 754 LVIVLGSGV 762
+ IV+G V
Sbjct: 323 IAIVVGVAV 331
Score = 50.4 bits (119), Expect = 6e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 609 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 664
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 715
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 35.8 bits (81), Expect = 0.16
Identities = 20/71 (28%), Positives = 32/71 (45%), Gaps = 4/71 (5%)
Query: 197 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-ASCGGTIHNATLGRIVSPEPGGA 255
T F CD G+ L G +T++C + +W+ P C+ S T + P+P
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEEG 308
Query: 256 VGPNLTCRWVI 266
+ +L WVI
Sbjct: 309 ILDSLDV-WVI 318
Score = 34.7 bits (78), Expect = 0.36
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 200 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 231
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
>gi|27502421 CD46 antigen, complement regulatory protein isoform 13
precursor [Homo sapiens]
Length = 373
Score = 80.1 bits (196), Expect = 8e-15
Identities = 66/199 (33%), Positives = 89/199 (44%), Gaps = 24/199 (12%)
Query: 528 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 584
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 585 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 638
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 639 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 695
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 696 TITCVPGHPSQWTSQPPLC 714
TI C S W P C
Sbjct: 267 TIVC--DSNSTWDPPVPKC 283
Score = 50.4 bits (119), Expect = 6e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 609 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 664
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 715
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 36.6 bits (83), Expect = 0.096
Identities = 18/56 (32%), Positives = 30/56 (53%), Gaps = 4/56 (7%)
Query: 550 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCA---DPGEIANGHR 602
+ TV+ ++C+ G+ L GSD + C + +W P C K+ T + P A+G R
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGPR 303
Score = 35.0 bits (79), Expect = 0.28
Identities = 14/56 (25%), Positives = 24/56 (42%), Gaps = 2/56 (3%)
Query: 197 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEP 252
T F CD G+ L G +T++C + +W+ P C+ + + P P
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRP 304
Score = 34.7 bits (78), Expect = 0.36
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 200 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 231
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
>gi|27502413 CD46 antigen, complement regulatory protein isoform 7
precursor [Homo sapiens]
Length = 378
Score = 80.1 bits (196), Expect = 8e-15
Identities = 66/199 (33%), Positives = 89/199 (44%), Gaps = 24/199 (12%)
Query: 528 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 584
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 585 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 638
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 639 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 695
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 696 TITCVPGHPSQWTSQPPLC 714
TI C S W P C
Sbjct: 267 TIVC--DSNSTWDPPVPKC 283
Score = 50.4 bits (119), Expect = 6e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 609 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 664
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 715
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 36.6 bits (83), Expect = 0.096
Identities = 19/70 (27%), Positives = 35/70 (50%), Gaps = 3/70 (4%)
Query: 550 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM--TCADPGEIANGHRTASDA 607
+ TV+ ++C+ G+ L GSD + C + +W P C K++ + P +++ T+S
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTT 307
Query: 608 GFPVGSHVQY 617
P S Y
Sbjct: 308 KSPASSASGY 317
Score = 34.7 bits (78), Expect = 0.36
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 200 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 231
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
Score = 34.7 bits (78), Expect = 0.36
Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 197 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232
T F CD G+ L G +T++C + +W+ P C+
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCL 284
>gi|27502411 CD46 antigen, complement regulatory protein isoform 6
precursor [Homo sapiens]
Length = 369
Score = 80.1 bits (196), Expect = 8e-15
Identities = 66/199 (33%), Positives = 89/199 (44%), Gaps = 24/199 (12%)
Query: 528 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 584
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 585 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 638
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 639 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 695
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 696 TITCVPGHPSQWTSQPPLC 714
TI C S W P C
Sbjct: 267 TIVC--DSNSTWDPPVPKC 283
Score = 50.4 bits (119), Expect = 6e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 609 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 664
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 715
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 34.7 bits (78), Expect = 0.36
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 200 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 231
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
Score = 34.7 bits (78), Expect = 0.36
Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 197 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232
T F CD G+ L G +T++C + +W+ P C+
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCL 284
Score = 32.0 bits (71), Expect = 2.4
Identities = 13/38 (34%), Positives = 22/38 (57%), Gaps = 1/38 (2%)
Query: 550 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQK 587
+ TV+ ++C+ G+ L GSD + C + +W P C K
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
>gi|27502409 CD46 antigen, complement regulatory protein isoform 5
precursor [Homo sapiens]
Length = 362
Score = 80.1 bits (196), Expect = 8e-15
Identities = 66/199 (33%), Positives = 89/199 (44%), Gaps = 24/199 (12%)
Query: 528 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 584
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 585 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 638
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 639 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 695
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 696 TITCVPGHPSQWTSQPPLC 714
TI C S W P C
Sbjct: 267 TIVC--DSNSTWDPPVPKC 283
Score = 50.4 bits (119), Expect = 6e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 609 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 664
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 715
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 34.7 bits (78), Expect = 0.36
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 200 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 231
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
Score = 34.7 bits (78), Expect = 0.36
Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 197 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232
T F CD G+ L G +T++C + +W+ P C+
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCL 284
Score = 32.0 bits (71), Expect = 2.4
Identities = 13/38 (34%), Positives = 22/38 (57%), Gaps = 1/38 (2%)
Query: 550 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQK 587
+ TV+ ++C+ G+ L GSD + C + +W P C K
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
>gi|27502407 CD46 antigen, complement regulatory protein isoform 3
precursor [Homo sapiens]
Length = 377
Score = 80.1 bits (196), Expect = 8e-15
Identities = 66/199 (33%), Positives = 89/199 (44%), Gaps = 24/199 (12%)
Query: 528 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 584
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 585 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 638
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 639 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 695
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 696 TITCVPGHPSQWTSQPPLC 714
TI C S W P C
Sbjct: 267 TIVC--DSNSTWDPPVPKC 283
Score = 50.4 bits (119), Expect = 6e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 609 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 664
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 715
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 36.6 bits (83), Expect = 0.096
Identities = 18/56 (32%), Positives = 30/56 (53%), Gaps = 4/56 (7%)
Query: 550 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCA---DPGEIANGHR 602
+ TV+ ++C+ G+ L GSD + C + +W P C K+ T + P A+G R
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGPR 303
Score = 35.0 bits (79), Expect = 0.28
Identities = 14/56 (25%), Positives = 24/56 (42%), Gaps = 2/56 (3%)
Query: 197 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEP 252
T F CD G+ L G +T++C + +W+ P C+ + + P P
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRP 304
Score = 34.7 bits (78), Expect = 0.36
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 200 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 231
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
>gi|27502405 CD46 antigen, complement regulatory protein isoform 14
precursor [Homo sapiens]
Length = 349
Score = 80.1 bits (196), Expect = 8e-15
Identities = 66/199 (33%), Positives = 89/199 (44%), Gaps = 24/199 (12%)
Query: 528 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 584
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 585 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 638
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 639 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 695
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 696 TITCVPGHPSQWTSQPPLC 714
TI C S W P C
Sbjct: 267 TIVC--DSNSTWDPPVPKC 283
Score = 50.4 bits (119), Expect = 6e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 609 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 664
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 715
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 34.7 bits (78), Expect = 0.36
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 200 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 231
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
Score = 34.7 bits (78), Expect = 0.36
Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 197 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232
T F CD G+ L G +T++C + +W+ P C+
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCL 284
Score = 32.0 bits (71), Expect = 2.4
Identities = 13/38 (34%), Positives = 22/38 (57%), Gaps = 1/38 (2%)
Query: 550 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQK 587
+ TV+ ++C+ G+ L GSD + C + +W P C K
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
>gi|27502402 CD46 antigen, complement regulatory protein isoform 1
precursor [Homo sapiens]
Length = 392
Score = 80.1 bits (196), Expect = 8e-15
Identities = 66/199 (33%), Positives = 89/199 (44%), Gaps = 24/199 (12%)
Query: 528 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 584
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 585 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 638
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 639 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 695
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 696 TITCVPGHPSQWTSQPPLC 714
TI C S W P C
Sbjct: 267 TIVC--DSNSTWDPPVPKC 283
Score = 50.4 bits (119), Expect = 6e-06
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 609 FPVGSHVQYRCLPGYSL--EGAAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 664
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 665 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 715
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+
Sbjct: 114 NG-------TYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICE 158
Score = 36.2 bits (82), Expect = 0.13
Identities = 18/66 (27%), Positives = 34/66 (51%), Gaps = 3/66 (4%)
Query: 550 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM--TCADPGEIANGHRTASDA 607
+ TV+ ++C+ G+ L GSD + C + +W P C K++ + P +++ T+S
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTT 307
Query: 608 GFPVGS 613
P S
Sbjct: 308 KSPASS 313
Score = 34.7 bits (78), Expect = 0.36
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 200 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 231
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
Score = 34.7 bits (78), Expect = 0.36
Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 197 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 232
T F CD G+ L G +T++C + +W+ P C+
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCL 284
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.137 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,123,186
Number of Sequences: 37866
Number of extensions: 2902361
Number of successful extensions: 33018
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 401
Number of HSP's successfully gapped in prelim test: 1031
Number of HSP's that attempted gapping in prelim test: 16624
Number of HSP's gapped (non-prelim): 10113
length of query: 809
length of database: 18,247,518
effective HSP length: 110
effective length of query: 699
effective length of database: 14,082,258
effective search space: 9843498342
effective search space used: 9843498342
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.