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Search of human proteins with 161333852
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1
[Homo sapiens]
(735 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1 ... 1488 0.0
gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2 ... 1325 0.0
gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens] 161 2e-39
gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens] 160 3e-39
gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens] 121 2e-27
gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens] 115 1e-25
gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens] 87 6e-17
gi|16306588 F-box and leucine-rich repeat protein 4 [Homo sapiens] 81 4e-15
gi|254039600 F-box and leucine-rich repeat protein 17 [Homo sapi... 77 4e-14
gi|164663798 antagonist of mitotic exit network 1 homolog [Homo ... 69 2e-11
gi|190194416 F-box and leucine-rich repeat protein 15 [Homo sapi... 68 3e-11
gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens] 64 5e-10
gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens] 64 5e-10
gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [... 59 2e-08
gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [... 58 4e-08
gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo ... 55 2e-07
gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens] 54 5e-07
gi|16306576 F-box and leucine-rich repeat protein 6 isoform 1 [H... 52 3e-06
gi|157168349 F-box and leucine-rich repeat protein 19 [Homo sapi... 52 3e-06
gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo ... 51 3e-06
gi|61742136 F-box and leucine-rich repeat protein 6 isoform 2 [H... 49 1e-05
gi|16306574 F-box and leucine-rich repeat protein 5 isoform 2 [H... 45 2e-04
gi|16306572 F-box and leucine-rich repeat protein 5 isoform 1 [H... 45 2e-04
gi|16506299 leucine rich repeat containing 42 [Homo sapiens] 44 5e-04
gi|169160755 PREDICTED: zyg-11 homolog A (C. elegans) [Homo sapi... 43 0.001
gi|88948888 PREDICTED: zyg-11 homolog A (C. elegans) [Homo sapiens] 43 0.001
gi|113408672 PREDICTED: zyg-11 homolog A [Homo sapiens] 43 0.001
gi|226437632 zyg-11 homolog A [Homo sapiens] 43 0.001
gi|148922963 F-box and leucine-rich repeat protein 21 [Homo sapi... 41 0.003
gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 fami... 40 0.010
>gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1
[Homo sapiens]
Length = 735
Score = 1488 bits (3852), Expect = 0.0
Identities = 735/735 (100%), Positives = 735/735 (100%)
Query: 1 MTPELMIKACSFYTGHLVKTHFCTWRDIARTNENVVLAEKMNRAVTCYNFRLQKSVFHHW 60
MTPELMIKACSFYTGHLVKTHFCTWRDIARTNENVVLAEKMNRAVTCYNFRLQKSVFHHW
Sbjct: 1 MTPELMIKACSFYTGHLVKTHFCTWRDIARTNENVVLAEKMNRAVTCYNFRLQKSVFHHW 60
Query: 61 HSYMEDQKEKLKNILLRIQQIIYCHKLTIILTKWRNTARHKSKKKEDELILKHELQLKKW 120
HSYMEDQKEKLKNILLRIQQIIYCHKLTIILTKWRNTARHKSKKKEDELILKHELQLKKW
Sbjct: 61 HSYMEDQKEKLKNILLRIQQIIYCHKLTIILTKWRNTARHKSKKKEDELILKHELQLKKW 120
Query: 121 KNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQ 180
KNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQ
Sbjct: 121 KNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQ 180
Query: 181 VNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRS 240
VNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRS
Sbjct: 181 VNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRS 240
Query: 241 VSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQN 300
VSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQN
Sbjct: 241 VSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQN 300
Query: 301 LSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDM 360
LSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDM
Sbjct: 301 LSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDM 360
Query: 361 PTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKF 420
PTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKF
Sbjct: 361 PTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKF 420
Query: 421 IDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMR 480
IDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMR
Sbjct: 421 IDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMR 480
Query: 481 IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGT 540
IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGT
Sbjct: 481 IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGT 540
Query: 541 DISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKA 600
DISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKA
Sbjct: 541 DISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKA 600
Query: 601 LAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQL 660
LAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQL
Sbjct: 601 LAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQL 660
Query: 661 RILKMQYCTNISKKAAQRMSSKVQQQEYNTNDPPRWFGYDREGNPVTELDNITSSKGALE 720
RILKMQYCTNISKKAAQRMSSKVQQQEYNTNDPPRWFGYDREGNPVTELDNITSSKGALE
Sbjct: 661 RILKMQYCTNISKKAAQRMSSKVQQQEYNTNDPPRWFGYDREGNPVTELDNITSSKGALE 720
Query: 721 LTVKKSTYSSEDQAA 735
LTVKKSTYSSEDQAA
Sbjct: 721 LTVKKSTYSSEDQAA 735
>gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2
[Homo sapiens]
Length = 690
Score = 1325 bits (3430), Expect = 0.0
Identities = 667/735 (90%), Positives = 675/735 (91%), Gaps = 45/735 (6%)
Query: 1 MTPELMIKACSFYTGHLVKTHFCTWRDIARTNENVVLAEKMNRAVTCYNFRLQKSVFHHW 60
MTPELMIKACSFYTGHLVKTHFCTWRDIARTNENVVLAEKMNRAVTCYNFRLQKSVFHHW
Sbjct: 1 MTPELMIKACSFYTGHLVKTHFCTWRDIARTNENVVLAEKMNRAVTCYNFRLQKSVFHHW 60
Query: 61 HSYMEDQKEKLKNILLRIQQIIYCHKLTIILTKWRNTARHKSKKKEDELILKHELQLKKW 120
HSYMEDQKEKLKNILLRIQQIIYCHKLTIILTKWRNTARHKSKKKEDELILKHELQLKKW
Sbjct: 61 HSYMEDQKEKLKNILLRIQQIIYCHKLTIILTKWRNTARHKSKKKEDELILKHELQLKKW 120
Query: 121 KNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQ 180
KNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQ
Sbjct: 121 KNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQ 180
Query: 181 VNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRS 240
VNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRS
Sbjct: 181 VNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRS 240
Query: 241 VSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQN 300
VSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQN
Sbjct: 241 VSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQN 300
Query: 301 LSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDM 360
LSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDM
Sbjct: 301 LSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDM 360
Query: 361 PTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKF 420
PTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKF
Sbjct: 361 PTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKF 420
Query: 421 IDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMR 480
IDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMR
Sbjct: 421 IDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMR 480
Query: 481 IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGT 540
IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGT
Sbjct: 481 IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGT 540
Query: 541 DISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKA 600
DISNEGLNVLSRHKKLKELSVSECYRITDDGI Q++D ++
Sbjct: 541 DISNEGLNVLSRHKKLKELSVSECYRITDDGI-------------------QITDSAMEM 581
Query: 601 LAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQL 660
L+ C L L I+GC +TD +E L QIGCKQL
Sbjct: 582 LSAKCHYLHILDISGCVLLTDQILEDL--------------------------QIGCKQL 615
Query: 661 RILKMQYCTNISKKAAQRMSSKVQQQEYNTNDPPRWFGYDREGNPVTELDNITSSKGALE 720
RILKMQYCTNISKKAAQRMSSKVQQQEYNTNDPPRWFGYDREGNPVTELDNITSSKGALE
Sbjct: 616 RILKMQYCTNISKKAAQRMSSKVQQQEYNTNDPPRWFGYDREGNPVTELDNITSSKGALE 675
Query: 721 LTVKKSTYSSEDQAA 735
LTVKKSTYSSEDQAA
Sbjct: 676 LTVKKSTYSSEDQAA 690
>gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens]
Length = 423
Score = 161 bits (408), Expect = 2e-39
Identities = 107/375 (28%), Positives = 193/375 (51%), Gaps = 14/375 (3%)
Query: 158 LPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQ 217
LP+ +L+IF +L + + C Q++ AW ++ S W ID + + + + + + +
Sbjct: 15 LPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFNFQIDVEGRVVENISK 74
Query: 218 RWRLNVLRLNFRGCL----LRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCPGV 273
R + +L+ RGC+ KTF +CRN++ LN++ C TD + +S C +
Sbjct: 75 RCGGFLRKLSLRGCIGVGDSSLKTF--AQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKL 132
Query: 274 LCLNLSN-TTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLS 332
L+L++ +ITN +++ + NL+ L+L++C + T G++ L GC L L L
Sbjct: 133 KHLDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALV--RGCRGLKALLLR 190
Query: 333 GCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDC 392
GCTQ+ + ++I N C ++ L + +TD V + C R+ +L +G +++D
Sbjct: 191 GCTQLEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQICRGCHRLQALCLSGCSNLTDA 250
Query: 393 TFRA--LSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS-P 449
+ A L+ +L+ + +TDA F + +N L + + +C ITDS+L LS
Sbjct: 251 SLTALGLNCPRLQILEAARCSHLTDAGFTLLARNCHELEKMDLEECILITDSTLIQLSIH 310
Query: 450 LKQLTVLNLANCVRIGDMGLKQFLDGPAS-MRIRELNLSNCVRLSDASVMKLSERCPNLN 508
+L L+L++C I D G+ + R+R L L NC+ ++D ++ L E C L
Sbjct: 311 CPKLQALSLSHCELITDDGILHLSNSTCGHERLRVLELDNCLLITDVALEHL-ENCRGLE 369
Query: 509 YLSLRNCEHLTAQGI 523
L L +C+ +T GI
Sbjct: 370 RLELYDCQQVTRAGI 384
Score = 136 bits (342), Expect = 8e-32
Identities = 86/283 (30%), Positives = 141/283 (49%), Gaps = 30/283 (10%)
Query: 402 LRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANC 461
LRK+ G V D+S K +N N+ H+ + C ITDS+ SLS
Sbjct: 80 LRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRF----------- 128
Query: 462 VRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQ 521
+++ L+L++CV ++++S+ +SE C NL YL+L C+ +T
Sbjct: 129 ----------------CSKLKHLDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKD 172
Query: 522 GIGYIVN-IFSLVSIDLSG-TDISNEGLNVLSRH-KKLKELSVSECYRITDDGIQAFCKS 578
GI +V L ++ L G T + +E L + + +L L++ C RITD+G+ C+
Sbjct: 173 GIEALVRGCRGLKALLLRGCTQLEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQICRG 232
Query: 579 SLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILD 638
L+ L +S CS L+D + AL + C L L A C +TD+ +L+ CH L +D
Sbjct: 233 CHRLQALCLSGCSNLTDASLTALGLNCPRLQILEAARCSHLTDAGFTLLARNCHELEKMD 292
Query: 639 ISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSS 681
+ C+L+TD L L I C +L+ L + +C I+ +S+
Sbjct: 293 LEECILITDSTLIQLSIHCPKLQALSLSHCELITDDGILHLSN 335
Score = 121 bits (304), Expect = 2e-27
Identities = 97/357 (27%), Positives = 168/357 (47%), Gaps = 35/357 (9%)
Query: 336 QISVQG--FRYIANSCTGIMH-LTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDC 392
QI V+G I+ C G + L++ + D+ +K + C I L G I+D
Sbjct: 61 QIDVEGRVVENISKRCGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDS 120
Query: 393 TFRALS--ACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSL-SP 449
T +LS KL+ + +T++S K I + NL ++ ++ C IT + +L
Sbjct: 121 TCYSLSRFCSKLKHLDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALVRG 180
Query: 450 LKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNY 509
+ L L L C ++ D LK + + LNL +C R++D V+++ C L
Sbjct: 181 CRGLKALLLRGCTQLEDEALKHIQN--YCHELVSLNLQSCSRITDEGVVQICRGCHRLQA 238
Query: 510 LSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKELSVSECYRITD 569
L L C +LT D S T + GLN +L+ L + C +TD
Sbjct: 239 LCLSGCSNLT----------------DASLTAL---GLNC----PRLQILEAARCSHLTD 275
Query: 570 DGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLS- 628
G ++ LE +D+ C ++D + L+I+C L +LS++ C ITD + LS
Sbjct: 276 AGFTLLARNCHELEKMDLEECILITDSTLIQLSIHCPKLQALSLSHCELITDDGILHLSN 335
Query: 629 AKCHY--LHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSSKV 683
+ C + L +L++ C+L+TD LE L+ C+ L L++ C +++ +RM +++
Sbjct: 336 STCGHERLRVLELDNCLLITDVALEHLE-NCRGLERLELYDCQQVTRAGIKRMRAQL 391
Score = 115 bits (287), Expect = 2e-25
Identities = 89/317 (28%), Positives = 148/317 (46%), Gaps = 12/317 (3%)
Query: 329 LDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPH 388
L L GC + + A +C I HL +N +TD+ +L CS++ L T
Sbjct: 83 LSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHLDLTSCVS 142
Query: 389 ISDCTFRALS-ACK-LRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRS 446
I++ + + +S C+ L + ++T + + + L + + C + D +L+
Sbjct: 143 ITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALVRGCRGLKALLLRGCTQLEDEALKH 202
Query: 447 LSPL-KQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCP 505
+ +L LNL +C RI D G+ Q G R++ L LS C L+DAS+ L CP
Sbjct: 203 IQNYCHELVSLNLQSCSRITDEGVVQICRG--CHRLQALCLSGCSNLTDASLTALGLNCP 260
Query: 506 NLNYLSLRNCEHLTAQGIGYIV-NIFSLVSIDLSGTD-ISNEGLNVLSRH-KKLKELSVS 562
L L C HLT G + N L +DL I++ L LS H KL+ LS+S
Sbjct: 261 RLQILEAARCSHLTDAGFTLLARNCHELEKMDLEECILITDSTLIQLSIHCPKLQALSLS 320
Query: 563 ECYRITDDGIQAFCKSSL---ILEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKI 619
C ITDDGI S+ L L++ C ++D+ ++ L C L L + C ++
Sbjct: 321 HCELITDDGILHLSNSTCGHERLRVLELDNCLLITDVALEHLE-NCRGLERLELYDCQQV 379
Query: 620 TDSAMEMLSAKCHYLHI 636
T + ++ + A+ ++ +
Sbjct: 380 TRAGIKRMRAQLPHVKV 396
Score = 47.8 bits (112), Expect = 4e-05
Identities = 22/81 (27%), Positives = 42/81 (51%)
Query: 608 LTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQY 667
L LS+ GC + DS+++ + C + L+++GC +TD L C +L+ L +
Sbjct: 80 LRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHLDLTS 139
Query: 668 CTNISKKAAQRMSSKVQQQEY 688
C +I+ + + +S + EY
Sbjct: 140 CVSITNSSLKGISEGCRNLEY 160
>gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens]
Length = 436
Score = 160 bits (406), Expect = 3e-39
Identities = 109/373 (29%), Positives = 196/373 (52%), Gaps = 10/373 (2%)
Query: 158 LPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQ 217
LP+ +L+IF +L + + C QV+ AW ++ S W ID + I + + + +
Sbjct: 28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISK 87
Query: 218 RWRLNVLRLNFRGCL-LRPKTFRSVS-HCRNLQELNVSDCPTFTDESMRHISEGCPGVLC 275
R + +L+ RGCL + R+ + +CRN++ LN++ C TD + +S+ C +
Sbjct: 88 RCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRH 147
Query: 276 LNLSN-TTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGC 334
L+L++ T+ITN +++ L L+ L++++C + T G+Q L GC L L L GC
Sbjct: 148 LDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALV--RGCGGLKALFLKGC 205
Query: 335 TQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTF 394
TQ+ + +YI C ++ L + +TD + + C ++ SL +G +I+D
Sbjct: 206 TQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAIL 265
Query: 395 RAL--SACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS-PLK 451
AL + +LR + ++TD F + +N L + + +C ITDS+L LS
Sbjct: 266 NALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCP 325
Query: 452 QLTVLNLANCVRIGDMGLKQFLDGP-ASMRIRELNLSNCVRLSDASVMKLSERCPNLNYL 510
+L VL+L++C I D G++ +G A ++ + L NC ++DAS+ L + C +L +
Sbjct: 326 RLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHL-KSCHSLERI 384
Query: 511 SLRNCEHLTAQGI 523
L +C+ +T GI
Sbjct: 385 ELYDCQQITRAGI 397
Score = 130 bits (327), Expect = 4e-30
Identities = 79/261 (30%), Positives = 136/261 (52%), Gaps = 12/261 (4%)
Query: 428 LSHIYMADCKGITDSSLRSLSP-LKQLTVLNLANCVRIGDM---GLKQFLDGPASMRIRE 483
L + + C G+ D++LR+ + + + VLNL C + D L +F ++R
Sbjct: 93 LRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCS-----KLRH 147
Query: 484 LNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVN-IFSLVSIDLSG-TD 541
L+L++C +++ S+ LSE CP L L++ C+ +T GI +V L ++ L G T
Sbjct: 148 LDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQ 207
Query: 542 ISNEGLNVLSRH-KKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKA 600
+ +E L + H +L L++ C +ITD+G+ C+ L+ L S CS ++D I+ A
Sbjct: 208 LEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNA 267
Query: 601 LAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQL 660
L C L L +A C ++TD L+ CH L +D+ CV +TD L L I C +L
Sbjct: 268 LGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRL 327
Query: 661 RILKMQYCTNISKKAAQRMSS 681
++L + +C I+ + + +
Sbjct: 328 QVLSLSHCELITDDGIRHLGN 348
Score = 118 bits (296), Expect = 2e-26
Identities = 88/287 (30%), Positives = 143/287 (49%), Gaps = 9/287 (3%)
Query: 402 LRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPL-KQLTVLNLAN 460
LRK+ G V D + + +N N+ + + C TD++ SLS +L L+LA+
Sbjct: 93 LRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLAS 152
Query: 461 CVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTA 520
C I +M LK +G + +LN+S C +++ + L C L L L+ C L
Sbjct: 153 CTSITNMSLKALSEG--CPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLED 210
Query: 521 QGIGYI-VNIFSLVSIDLSGT-DISNEGLNVLSRH-KKLKELSVSECYRITDDGIQAFCK 577
+ + YI + LV+++L I++EGL + R KL+ L S C ITD + A +
Sbjct: 211 EALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQ 270
Query: 578 SSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHIL 637
+ L L+V+ CSQL+D+ LA C L + + C +ITDS + LS C L +L
Sbjct: 271 NCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVL 330
Query: 638 DISGCVLLTDQILEDLQIGC---KQLRILKMQYCTNISKKAAQRMSS 681
+S C L+TD + L G QL ++++ C I+ + + + S
Sbjct: 331 SLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKS 377
Score = 30.0 bits (66), Expect = 8.0
Identities = 15/63 (23%), Positives = 28/63 (44%), Gaps = 1/63 (1%)
Query: 619 ITDSAMEMLSAKCH-YLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQ 677
I +E +S +C +L L + GC+ + D L C+ + +L + CT +
Sbjct: 77 IEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCT 136
Query: 678 RMS 680
+S
Sbjct: 137 SLS 139
>gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens]
Length = 491
Score = 121 bits (304), Expect = 2e-27
Identities = 103/419 (24%), Positives = 179/419 (42%), Gaps = 65/419 (15%)
Query: 152 KCDISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKY 211
+ I LP+ +++QIF +L + C +V W + LW I + + + D+
Sbjct: 111 QASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTG-ETINVDRA 169
Query: 212 IVSTLQRWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCP 271
+ L R C P C L+ + VS C TD + I++ CP
Sbjct: 170 LKV-----------LTRRLCQDTPNV------CLMLETVTVSGCRRLTDRGLYTIAQCCP 212
Query: 272 GVL------CLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFT------DKGLQYLNL 319
+ C N+SN + + + L P NL++L ++ C + T + ++ L
Sbjct: 213 ELRRLEVSGCYNISNEAVFD-VVSLCP----NLEHLDVSGCSKVTCISLTREASIKLSPL 267
Query: 320 GNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRIT 379
+ YLD++ C + +G IA CT + HL + LTD ++ LV C+ I
Sbjct: 268 HGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIK 327
Query: 380 SLVFTGAPHISDCTFRALS--ACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCK 437
L + +SD R ++ +LR + RVTD +++ K L ++ C+
Sbjct: 328 ELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCE 387
Query: 438 GITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASV 497
GITD + L+ NC +++ L++ C +SD +
Sbjct: 388 GITDHGVEYLA----------KNCT-----------------KLKSLDIGKCPLVSDTGL 420
Query: 498 MKLSERCPNLNYLSLRNCEHLTAQGIGYI-VNIFSLVSIDLSGTDISNEGLNVLSRHKK 555
L+ C NL LSL++CE +T QG+ + N F L ++++ ++S E L + RH K
Sbjct: 421 ECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCK 479
Score = 120 bits (300), Expect = 6e-27
Identities = 86/323 (26%), Positives = 152/323 (47%), Gaps = 42/323 (13%)
Query: 321 NGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITS 380
N C L + +SGC +++ +G IA C + L ++ +++ V +V C +
Sbjct: 183 NVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEH 242
Query: 381 LVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGIT 440
L +G ++ + ++ KL + K++ S +++D M DC +
Sbjct: 243 LDVSGCSKVTCISLTREASIKLSPLH---GKQI---SIRYLD----------MTDCFVLE 286
Query: 441 DSSLRSLSP-LKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMK 499
D L +++ QLT L L CVR+ D GL+ + AS I+EL++S+C +SD + +
Sbjct: 287 DEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCAS--IKELSVSDCRFVSDFGLRE 344
Query: 500 LSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKEL 559
+++ L YLS+ +C +T GI Y+ S KL+ L
Sbjct: 345 IAKLESRLRYLSIAHCGRVTDVGIRYVAKYCS-----------------------KLRYL 381
Query: 560 SVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKI 619
+ C ITD G++ K+ L+ LD+ C +SD ++ LA+ C NL LS+ C I
Sbjct: 382 NARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESI 441
Query: 620 TDSAMEMLSAKCHYLHILDISGC 642
T +++++A C L L++ C
Sbjct: 442 TGQGLQIVAANCFDLQTLNVQDC 464
Score = 115 bits (288), Expect = 1e-25
Identities = 80/300 (26%), Positives = 147/300 (49%), Gaps = 26/300 (8%)
Query: 375 CSRITSLVFTGAPHISDCTFRALSAC--KLRKIRFEGNKRVTDASFKFIDKNYPNLSHIY 432
C + ++ +G ++D ++ C +LR++ G +++ + + PNL H+
Sbjct: 185 CLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLD 244
Query: 433 MADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRL 492
++ C +T SL + +K + + KQ + IR L++++C L
Sbjct: 245 VSGCSKVTCISLTREASIK------------LSPLHGKQ-------ISIRYLDMTDCFVL 285
Query: 493 SDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTD---ISNEGLNV 549
D + ++ C L +L LR C LT +G+ Y+V I+ +LS +D +S+ GL
Sbjct: 286 EDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLV-IYCASIKELSVSDCRFVSDFGLRE 344
Query: 550 LSR-HKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINL 608
+++ +L+ LS++ C R+TD GI+ K L +L+ C ++D ++ LA C L
Sbjct: 345 IAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKL 404
Query: 609 TSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYC 668
SL I CP ++D+ +E L+ C L L + C +T Q L+ + C L+ L +Q C
Sbjct: 405 KSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDC 464
Score = 84.0 bits (206), Expect = 5e-16
Identities = 56/231 (24%), Positives = 106/231 (45%), Gaps = 23/231 (9%)
Query: 453 LTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSL 512
L + ++ C R+ D GL + +R L +S C +S+ +V + CPNL +L +
Sbjct: 188 LETVTVSGCRRLTDRGL--YTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDV 245
Query: 513 RNCEHLTAQGIGYIVNIFSLVSIDLS---GTDISNEGLNVLSRHKKLKELSVSECYRITD 569
C +T +++ SI LS G IS ++ L +++C+ + D
Sbjct: 246 SGCSKVTC------ISLTREASIKLSPLHGKQIS------------IRYLDMTDCFVLED 287
Query: 570 DGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSA 629
+G+ L HL + C +L+D ++ L IYC ++ LS++ C ++D + ++
Sbjct: 288 EGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAK 347
Query: 630 KCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMS 680
L L I+ C +TD + + C +LR L + C I+ + ++
Sbjct: 348 LESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLA 398
Score = 43.5 bits (101), Expect = 7e-04
Identities = 19/77 (24%), Positives = 44/77 (57%)
Query: 605 CINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILK 664
C+ L +++++GC ++TD + ++ C L L++SGC ++++ + D+ C L L
Sbjct: 185 CLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLD 244
Query: 665 MQYCTNISKKAAQRMSS 681
+ C+ ++ + R +S
Sbjct: 245 VSGCSKVTCISLTREAS 261
>gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens]
Length = 418
Score = 115 bits (289), Expect = 1e-25
Identities = 87/265 (32%), Positives = 135/265 (50%), Gaps = 15/265 (5%)
Query: 427 NLSHIYMADCKGITDSSLRSLSP-LKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELN 485
+L + ++ CK ITDSSL ++ LK L VL L C I + GL G R++ LN
Sbjct: 118 SLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWG--LQRLKSLN 175
Query: 486 LSNCVRLSDASVMKLS-------ERCPNLNYLSLRNCEHLTAQGIGYI---VNIFSLVSI 535
L +C LSD + L+ E C L L+L++C+ LT + +I + L+++
Sbjct: 176 LRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNL 235
Query: 536 DLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSD 595
G IS+ GL LS L+ L++ C I+D GI SL L LDVS+C ++ D
Sbjct: 236 SFCG-GISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGD 294
Query: 596 MIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQI 655
+ +A L SLS+ C I+D + + + H L L+I CV +TD+ LE +
Sbjct: 295 QSLAYIAQGLDGLKSLSLCSC-HISDDGINRMVRQMHGLRTLNIGQCVRITDKGLELIAE 353
Query: 656 GCKQLRILKMQYCTNISKKAAQRMS 680
QL + + CT I+K+ +R++
Sbjct: 354 HLSQLTGIDLYGCTRITKRGLERIT 378
Score = 108 bits (269), Expect = 2e-23
Identities = 115/486 (23%), Positives = 197/486 (40%), Gaps = 98/486 (20%)
Query: 151 LKCDISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDK 210
++ IS L + IF YL ++D QV AW S+W ++
Sbjct: 1 METHISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPS 60
Query: 211 YIVSTLQRWRLNVLRLNFRGCLLRPKTFRSVSHC----RNLQELNVSDCPTFTDESMRHI 266
S R V L+ R RS+S+ N++ LN+S C TD + H
Sbjct: 61 LFPSLQARGIRRVQILSLR---------RSLSYVIQGMANIESLNLSGCYNLTDNGLGHA 111
Query: 267 SEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGL----QYLNLGNG 322
+ +L+ L+L+ C++ TD L QYL
Sbjct: 112 ------------------------FVQEIGSLRALNLSLCKQITDSSLGRIAQYLK---- 143
Query: 323 CHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLV 382
L L+L GC+ I+ G IA + L + L+D
Sbjct: 144 --GLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSD----------------- 184
Query: 383 FTGAPHISDCTFRALSACK-LRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITD 441
G H++ T A C L ++ + +++TD S K I + L + ++ C GI+D
Sbjct: 185 -VGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISD 243
Query: 442 SSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLS 501
+ L LS + L LNL +C I D G+ G S+R+ L++S C ++ D S+ ++
Sbjct: 244 AGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMG--SLRLSGLDVSFCDKVGDQSLAYIA 301
Query: 502 ERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKK-LKELS 560
+ L LSL +C IS++G+N + R L+ L+
Sbjct: 302 QGLDGLKSLSLCSCH-------------------------ISDDGINRMVRQMHGLRTLN 336
Query: 561 VSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALA-IYCINLTSLSIAGCPKI 619
+ +C RITD G++ + L +D+ C++++ ++ + + C+ + +L G ++
Sbjct: 337 IGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERITQLPCLKVLNL---GLWQM 393
Query: 620 TDSAME 625
TDS E
Sbjct: 394 TDSEKE 399
Score = 55.8 bits (133), Expect = 1e-07
Identities = 38/141 (26%), Positives = 69/141 (48%), Gaps = 11/141 (7%)
Query: 549 VLSRHKKLKELSVSECYRITDDGI-QAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCIN 607
V+ ++ L++S CY +TD+G+ AF + L L++S C Q++D + +A Y
Sbjct: 85 VIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQYLKG 144
Query: 608 LTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQ----------IGC 657
L L + GC IT++ + +++ L L++ C L+D + L +G
Sbjct: 145 LEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGL 204
Query: 658 KQLRILKMQYCTNISKKAAQR 678
+QL + Q T++S K R
Sbjct: 205 EQLTLQDCQKLTDLSLKHISR 225
>gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens]
Length = 479
Score = 87.0 bits (214), Expect = 6e-17
Identities = 82/273 (30%), Positives = 134/273 (49%), Gaps = 22/273 (8%)
Query: 439 ITDSSLR-SLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASV 497
ITD+ L L ++ + L L+ C + GL L S RI L++S+C+ ++D ++
Sbjct: 205 ITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSL----SARITSLSVSDCINVADDAI 260
Query: 498 MKLSERCPNLNYLSLRNCEHLTAQGIGYIV--NIFSLVSIDL-SGTDISNEGL-NVLSRH 553
+S+ PNL LSL+ H+T + Y S ++ L S +I+N G+ NV+
Sbjct: 261 AAISQLLPNLAELSLQ-AYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSL 319
Query: 554 KKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSI 613
L LS+S C ++TDDG++ ++ L LD+S+C +++DM ++ +A L L +
Sbjct: 320 PNLTALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVL 379
Query: 614 AGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISK 673
C +ITD+ + LS L L + C + D L+ L + LR+L C ++
Sbjct: 380 DRCVRITDTGLSYLSTMSS-LRSLYLRWCCQVQDFGLKHL-LALGSLRLLSPAGCPLLTT 437
Query: 674 KAAQRMSSKVQQQEYN----TNDP---PRWFGY 699
+S VQ QE TN P P F Y
Sbjct: 438 TG---LSGLVQLQELEELELTNCPGATPELFKY 467
Score = 67.8 bits (164), Expect = 3e-11
Identities = 72/304 (23%), Positives = 119/304 (39%), Gaps = 57/304 (18%)
Query: 223 VLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTT 282
V+RL GC + S + L+VSDC D+++ IS+ P + L+L
Sbjct: 220 VVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYH 279
Query: 283 ITNRTMRLLP-RHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQG 341
+T+ + R H+ L L C T+ G+ +N+ + L L LSGC+++
Sbjct: 280 VTDTALAYFTARQGHSTHTLRLLSCWEITNHGV--VNVVHSLPNLTALSLSGCSKV---- 333
Query: 342 FRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACK 401
TD+ V+ + E ++ SL + P
Sbjct: 334 ----------------------TDDGVELVAENLRKLRSLDLSWCP-------------- 357
Query: 402 LRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANC 461
R+TD + +++ + L + + C ITD+ L LS + L L L C
Sbjct: 358 ----------RITDMALEYVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWC 407
Query: 462 VRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQ 521
++ D GLK L A +R L+ + C L+ + L + L L L NC T +
Sbjct: 408 CQVQDFGLKHLL---ALGSLRLLSPAGCPLLTTTGLSGLVQ-LQELEELELTNCPGATPE 463
Query: 522 GIGY 525
Y
Sbjct: 464 LFKY 467
Score = 47.8 bits (112), Expect = 4e-05
Identities = 41/154 (26%), Positives = 67/154 (43%), Gaps = 6/154 (3%)
Query: 246 NLQELNVSDCPTFTDESMRHISEGCPGVLCLNLS-NTTITNRTMRLLPRHFHNLQNLSLA 304
NL L++S C TD+ + ++E + L+LS IT+ + + H L+ L L
Sbjct: 321 NLTALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLD 380
Query: 305 YCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLT 364
C R TD GL YL+ + L L C Q+ G +++ + + L+ P LT
Sbjct: 381 RCVRITDTGLSYLSTMSSLRSLY---LRWCCQVQDFGLKHLL-ALGSLRLLSPAGCPLLT 436
Query: 365 DNCVKALVEKCSRITSLVFTGAPHISDCTFRALS 398
+ LV+ + L T P + F+ S
Sbjct: 437 TTGLSGLVQ-LQELEELELTNCPGATPELFKYFS 469
>gi|16306588 F-box and leucine-rich repeat protein 4 [Homo sapiens]
Length = 621
Score = 80.9 bits (198), Expect = 4e-15
Identities = 64/245 (26%), Positives = 104/245 (42%), Gaps = 32/245 (13%)
Query: 468 GLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIV 527
G +FL S +R L LS L++ + +SE CPNL L+L +C+ L Q +I
Sbjct: 365 GFSRFLKVCGSELVR-LELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIA 423
Query: 528 NIFSLVSIDLSGTDISNEGLNVL-----------------------------SRHKKLKE 558
+ SL + L T + L + ++ KKL+
Sbjct: 424 KLCSLKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRT 483
Query: 559 LSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQL--SDMIIKALAIYCINLTSLSIAGC 616
L + C IT++GI +LE LD+ +C L S LA NL L +
Sbjct: 484 LDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTAN 543
Query: 617 PKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAA 676
+ D+ ++ L+ C L LDI G +++ L L CK L +L + +C+ I +A
Sbjct: 544 RSVCDTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAV 603
Query: 677 QRMSS 681
+++
Sbjct: 604 LELNA 608
Score = 68.6 bits (166), Expect = 2e-11
Identities = 53/209 (25%), Positives = 93/209 (44%), Gaps = 5/209 (2%)
Query: 244 CRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSL 303
C NLQ LN+S C ++ HI++ C + L L T + + + LQ+LSL
Sbjct: 400 CPNLQALNLSSCDKLPPQAFNHIAKLC-SLKRLVLYRTKVEQTALLSILNFCSELQHLSL 458
Query: 304 AYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTL 363
C D + +G C KL LDL C I+ G +A+ C + L + PTL
Sbjct: 459 GSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTL 518
Query: 364 --TDNCVKALVEKCSRITSLVFTGAPHISDCTF--RALSACKLRKIRFEGNKRVTDASFK 419
+ C L + + L T + D A + +L+++ G + V+ AS +
Sbjct: 519 QSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILGTRMVSPASLR 578
Query: 420 FIDKNYPNLSHIYMADCKGITDSSLRSLS 448
+ ++ +LS + ++ C I + ++ L+
Sbjct: 579 KLLESCKDLSLLDVSFCSQIDNRAVLELN 607
>gi|254039600 F-box and leucine-rich repeat protein 17 [Homo
sapiens]
Length = 303
Score = 77.4 bits (189), Expect = 4e-14
Identities = 64/283 (22%), Positives = 126/283 (44%), Gaps = 36/283 (12%)
Query: 411 KRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSL-SPLKQLTVLNLANCVRIGDMGL 469
K+++D S + + P L +++ + +TD L+ L S ++L ++ C +I D G+
Sbjct: 25 KQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGM 84
Query: 470 KQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNI 529
G ++++ + + ++D SV +E CP L Y+ C +T++G+ ++ +
Sbjct: 85 IVIAKG--CLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCS-VTSKGVIHLTKL 141
Query: 530 FSLVSIDLSG-TDISNEG-LNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDV 587
+L S+DL T++ NE + ++ R K L L++ + I D ++ K
Sbjct: 142 RNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQ------- 194
Query: 588 SYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTD 647
NL L + C KITD A+ + + +D+ C +TD
Sbjct: 195 -------------------NLKELYLVSC-KITDYALIAIGRYSMTIETVDVGWCKEITD 234
Query: 648 QILEDLQIGCKQLRILKMQYCTNISKKAAQRMSSKVQQQEYNT 690
Q + K LR L + C +++ +++ VQQ + T
Sbjct: 235 QGATLIAQSSKSLRYLGLMRCDKVNEVTVEQL---VQQYPHIT 274
Score = 75.9 bits (185), Expect = 1e-13
Identities = 72/281 (25%), Positives = 122/281 (43%), Gaps = 44/281 (15%)
Query: 270 CPGVL------CLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGC 323
CPG+L C LS+T+I + H LQ + + + TD+GL+ LG+ C
Sbjct: 13 CPGLLRYTAYRCKQLSDTSII-----AVASHCPLLQKVHVGNQDKLTDEGLK--QLGSKC 65
Query: 324 HKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVF 383
+L + C +IS +G IA C + + + + +TD VKA E C + + F
Sbjct: 66 RELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGF 125
Query: 384 TGAPHISD-----CTFRALSACKLRKIRFEGNKRV---------------------TDAS 417
G S R LS+ LR I N+ V D
Sbjct: 126 MGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRC 185
Query: 418 FKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQ-LTVLNLANCVRIGDMGLKQFLDGP 476
+ I K NL +Y+ CK ITD +L ++ + +++ C I D G L
Sbjct: 186 VEVIAKEGQNLKELYLVSCK-ITDYALIAIGRYSMTIETVDVGWCKEITDQGAT--LIAQ 242
Query: 477 ASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLS-LRNCE 516
+S +R L L C ++++ +V +L ++ P++ + + L++C+
Sbjct: 243 SSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCK 283
Score = 75.5 bits (184), Expect = 2e-13
Identities = 75/303 (24%), Positives = 134/303 (44%), Gaps = 33/303 (10%)
Query: 337 ISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRA 396
+S G +A C G++ T L+D + A+ C + + ++D +
Sbjct: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQ 60
Query: 397 L-SACK-LRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSP-LKQL 453
L S C+ L+ I F +++D I K L IYM + K +TD S+++ + +L
Sbjct: 61 LGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPEL 120
Query: 454 TVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLR 513
+ C + K + + L+L + L + +VM++ +RC NL+ L+L
Sbjct: 121 QYVGFMGC----SVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNL- 175
Query: 514 NCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQ 573
C + +I+N D I+ EG N LKEL + C +ITD +
Sbjct: 176 -C-------LNWIIN-------DRCVEVIAKEGQN-------LKELYLVSC-KITDYALI 212
Query: 574 AFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHY 633
A + S+ +E +DV +C +++D +A +L L + C K+ + +E L + Y
Sbjct: 213 AIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQQ--Y 270
Query: 634 LHI 636
HI
Sbjct: 271 PHI 273
Score = 61.2 bits (147), Expect = 3e-09
Identities = 45/183 (24%), Positives = 82/183 (44%), Gaps = 29/183 (15%)
Query: 489 CVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLN 548
C +LSD S++ ++ CP L + + N + LT +EGL
Sbjct: 24 CKQLSDTSIIAVASHCPLLQKVHVGNQDKLT------------------------DEGLK 59
Query: 549 VL-SRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCIN 607
L S+ ++LK++ +CY+I+D+G+ K L L+ + + ++D +KA A +C
Sbjct: 60 QLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPE 119
Query: 608 LTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQY 667
L + GC + + + K L LD+ L ++ + ++ CK L L +
Sbjct: 120 LQYVGFMGCSVTSKGVIHL--TKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNL-- 175
Query: 668 CTN 670
C N
Sbjct: 176 CLN 178
Score = 53.5 bits (127), Expect = 7e-07
Identities = 50/234 (21%), Positives = 96/234 (41%), Gaps = 31/234 (13%)
Query: 242 SHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNL-SNTTITNRTMRLLPRHFHNLQN 300
S CR L++++ C +DE M I++GC + + + N +T+++++ H LQ
Sbjct: 63 SKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQY 122
Query: 301 LSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDM 360
+ C T KG+ +L L LDL T++ + I C + L +
Sbjct: 123 VGFMGC-SVTSKGVIHL---TKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLN 178
Query: 361 PTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKF 420
+ D CV+ + ++ + L L +CK +TD +
Sbjct: 179 WIINDRCVEVIAKEGQNLKELY--------------LVSCK-----------ITDYALIA 213
Query: 421 IDKNYPNLSHIYMADCKGITDSSLRSLS-PLKQLTVLNLANCVRIGDMGLKQFL 473
I + + + + CK ITD ++ K L L L C ++ ++ ++Q +
Sbjct: 214 IGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLV 267
Score = 53.5 bits (127), Expect = 7e-07
Identities = 40/155 (25%), Positives = 73/155 (47%), Gaps = 4/155 (2%)
Query: 226 LNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLS-NTTIT 284
+ F GC + K ++ RNL L++ +E++ I + C + LNL N I
Sbjct: 123 VGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIIN 182
Query: 285 NRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRY 344
+R + ++ + NL+ L L C + TD L + +G + +D+ C +I+ QG
Sbjct: 183 DRCVEVIAKEGQNLKELYLVSC-KITDYAL--IAIGRYSMTIETVDVGWCKEITDQGATL 239
Query: 345 IANSCTGIMHLTINDMPTLTDNCVKALVEKCSRIT 379
IA S + +L + + + V+ LV++ IT
Sbjct: 240 IAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHIT 274
Score = 48.1 bits (113), Expect = 3e-05
Identities = 25/99 (25%), Positives = 50/99 (50%)
Query: 590 CSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQI 649
C QLSD I A+A +C L + + K+TD ++ L +KC L + C ++D+
Sbjct: 24 CKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEG 83
Query: 650 LEDLQIGCKQLRILKMQYCTNISKKAAQRMSSKVQQQEY 688
+ + GC +L+ + MQ ++ ++ + + + +Y
Sbjct: 84 MIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQY 122
Score = 45.1 bits (105), Expect = 2e-04
Identities = 33/133 (24%), Positives = 62/133 (46%), Gaps = 1/133 (0%)
Query: 542 ISNEGLNVLS-RHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKA 600
+S+ G+ VL+ + L + C +++D I A +L+ + V +L+D +K
Sbjct: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQ 60
Query: 601 LAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQL 660
L C L + C KI+D M +++ C L + + L+TDQ ++ C +L
Sbjct: 61 LGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPEL 120
Query: 661 RILKMQYCTNISK 673
+ + C+ SK
Sbjct: 121 QYVGFMGCSVTSK 133
Score = 40.0 bits (92), Expect = 0.008
Identities = 33/188 (17%), Positives = 76/188 (40%), Gaps = 25/188 (13%)
Query: 492 LSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLS 551
+SD V L+ +CP L + C+ L+ I + V S
Sbjct: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSI-----------------------IAVAS 37
Query: 552 RHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSL 611
L+++ V ++TD+G++ L+ + C ++SD + +A C+ L +
Sbjct: 38 HCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRI 97
Query: 612 SIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNI 671
+ +TD +++ + C L + GC + + ++ ++ + L L +++ T +
Sbjct: 98 YMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKL--RNLSSLDLRHITEL 155
Query: 672 SKKAAQRM 679
+ +
Sbjct: 156 DNETVMEI 163
>gi|164663798 antagonist of mitotic exit network 1 homolog [Homo
sapiens]
Length = 258
Score = 68.6 bits (166), Expect = 2e-11
Identities = 43/149 (28%), Positives = 74/149 (49%), Gaps = 5/149 (3%)
Query: 534 SIDLSGTDISNEGLNVLSRHKKLKELSVSEC----YRITDDGIQAFCKSSLILEHLDVSY 589
++DL DIS+ L LS +KLK+L+++ +T +GI+A S L +
Sbjct: 65 TLDLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHEASLKR 124
Query: 590 CSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQI 649
C L+D + ALA+ C L + + GC ITD ++ L C +L +D S + +
Sbjct: 125 CCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSATQVSDSGV 184
Query: 650 LEDLQIGC-KQLRILKMQYCTNISKKAAQ 677
+ + C K+L + M +C N++ A +
Sbjct: 185 IALVSGPCAKKLEEIHMGHCVNLTDGAVE 213
Score = 67.4 bits (163), Expect = 5e-11
Identities = 65/270 (24%), Positives = 113/270 (41%), Gaps = 43/270 (15%)
Query: 363 LTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKFID 422
L D C+ ++ SR + + P+I D + +S ++TD++ I
Sbjct: 10 LLDLCLWCFMKNISRYLTDIKPLPPNIKDRLIKIMSM----------QGQITDSNISEI- 58
Query: 423 KNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNL----ANCVRIGDMGLKQFLDGPAS 478
+P + + + C I+D++L LS ++L LNL N V + G+K +
Sbjct: 59 -LHPEVQTLDLRSCD-ISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVAS--SC 114
Query: 479 MRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYI-VNIFSLVSIDL 537
+ E +L C L+D V+ L+ C L + L C +T + + N L +D
Sbjct: 115 SYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDF 174
Query: 538 SGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMI 597
S T +S+ G+ L K+L E + + +C L+D
Sbjct: 175 SATQVSDSGVIALVSGPCAKKL-----------------------EEIHMGHCVNLTDGA 211
Query: 598 IKALAIYCINLTSLSIAGCPKITDSAMEML 627
++A+ YC + L GCP ITD + E+L
Sbjct: 212 VEAVLTYCPQIRILLFHGCPLITDHSREVL 241
Score = 58.9 bits (141), Expect = 2e-08
Identities = 49/207 (23%), Positives = 99/207 (47%), Gaps = 40/207 (19%)
Query: 491 RLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGT-----DISNE 545
+++D+++ ++ P + L LR+C+ ++ + ++ N L ++L+ + +++E
Sbjct: 49 QITDSNISEILH--PEVQTLDLRSCD-ISDAALLHLSNCRKLKKLNLNASKGNRVSVTSE 105
Query: 546 GLN-VLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIY 604
G+ V S L E S+ C +TD+G+ A + +L+ +D+ C ++D+ + AL
Sbjct: 106 GIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKN 165
Query: 605 C-------INLTSLSIAG--------------------CPKITDSAMEMLSAKCHYLHIL 637
C + T +S +G C +TD A+E + C + IL
Sbjct: 166 CPFLQCVDFSATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRIL 225
Query: 638 DISGCVLLTD---QILEDLQIGCKQLR 661
GC L+TD ++LE L +G +L+
Sbjct: 226 LFHGCPLITDHSREVLEQL-VGPNKLK 251
Score = 52.0 bits (123), Expect = 2e-06
Identities = 52/201 (25%), Positives = 89/201 (44%), Gaps = 13/201 (6%)
Query: 198 IDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVS---- 253
I S++ I D I L V L+ R C + +S+CR L++LN++
Sbjct: 41 IKIMSMQGQITDSNISEILHP---EVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKG 97
Query: 254 DCPTFTDESMRHISEGCPGVLCLNLSN-TTITNRTMRLLPRHFHNLQNLSLAYCRRFTDK 312
+ + T E ++ ++ C + +L +T+ + L + L+ + L C TD
Sbjct: 98 NRVSVTSEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDV 157
Query: 313 GLQYLNLGNGCHKLIYLDLSGCTQISVQG-FRYIANSCT-GIMHLTINDMPTLTDNCVKA 370
L LG C L +D S TQ+S G ++ C + + + LTD V+A
Sbjct: 158 SLH--ALGKNCPFLQCVDFS-ATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEA 214
Query: 371 LVEKCSRITSLVFTGAPHISD 391
++ C +I L+F G P I+D
Sbjct: 215 VLTYCPQIRILLFHGCPLITD 235
Score = 42.7 bits (99), Expect = 0.001
Identities = 43/177 (24%), Positives = 76/177 (42%), Gaps = 12/177 (6%)
Query: 298 LQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGC----TQISVQGFRYIANSCTGIM 353
+Q L L C +D L +L+ C KL L+L+ ++ +G + +A+SC+ +
Sbjct: 63 VQTLDLRSCD-ISDAALLHLS---NCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLH 118
Query: 354 HLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSA-CKLRKIRFEGNKR 412
++ LTD V AL C + + G I+D + AL C + +
Sbjct: 119 EASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSATQ 178
Query: 413 VTDASFKFIDKN--YPNLSHIYMADCKGITDSSLRS-LSPLKQLTVLNLANCVRIGD 466
V+D+ + L I+M C +TD ++ + L+ Q+ +L C I D
Sbjct: 179 VSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITD 235
>gi|190194416 F-box and leucine-rich repeat protein 15 [Homo
sapiens]
Length = 300
Score = 68.2 bits (165), Expect = 3e-11
Identities = 53/204 (25%), Positives = 96/204 (47%), Gaps = 25/204 (12%)
Query: 481 IRELNLSNCVR-LSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSG 539
++EL L+ C LSD ++ + R P L ++L C L+ + +G +
Sbjct: 89 LQELALAPCHEWLSDEDLVPVLARNPQLRSVALGGCGQLSRRALGALA------------ 136
Query: 540 TDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIK 599
EG +L+ LS++ C + ++ LE LD++ C QL D I
Sbjct: 137 -----EGC------PRLQRLSLAHCDWVDGLALRGLADRCPALEELDLTACRQLKDEAIV 185
Query: 600 ALAIYC-INLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCK 658
LA L SLS+A + D+A++ L+ C LH LD++GC+ + + L C
Sbjct: 186 YLAQRRGAGLRSLSLAVNANVGDAAVQELARNCPELHHLDLTGCLRVGSDGVRTLAEYCP 245
Query: 659 QLRILKMQYCTNISKKAAQRMSSK 682
LR L++++C ++++ + R+ +
Sbjct: 246 VLRSLRVRHCHHVAESSLSRLRKR 269
Score = 58.5 bits (140), Expect = 2e-08
Identities = 48/202 (23%), Positives = 88/202 (43%), Gaps = 26/202 (12%)
Query: 428 LSHIYMADC-KGITDSSLRS-LSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELN 485
L + +A C + ++D L L+ QL + L C ++ L +G R++ L+
Sbjct: 89 LQELALAPCHEWLSDEDLVPVLARNPQLRSVALGGCGQLSRRALGALAEG--CPRLQRLS 146
Query: 486 LSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNE 545
L++C + ++ L++RCP L L L C L + I Y+
Sbjct: 147 LAHCDWVDGLALRGLADRCPALEELDLTACRQLKDEAIVYLAQ----------------- 189
Query: 546 GLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYC 605
R L+ LS++ + D +Q ++ L HLD++ C ++ ++ LA YC
Sbjct: 190 -----RRGAGLRSLSLAVNANVGDAAVQELARNCPELHHLDLTGCLRVGSDGVRTLAEYC 244
Query: 606 INLTSLSIAGCPKITDSAMEML 627
L SL + C + +S++ L
Sbjct: 245 PVLRSLRVRHCHHVAESSLSRL 266
Score = 51.6 bits (122), Expect = 3e-06
Identities = 44/194 (22%), Positives = 82/194 (42%), Gaps = 7/194 (3%)
Query: 283 ITNRTMRLLPRHFHNLQNLSLAYCRRF-TDKGLQYLNLGNGCHKLIYLDLSGCTQISVQG 341
I + L R LQ L+LA C + +D+ L + N +L + L GC Q+S +
Sbjct: 74 IPRAALARLLRDAEGLQELALAPCHEWLSDEDLVPVLARNP--QLRSVALGGCGQLSRRA 131
Query: 342 FRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALS--- 398
+A C + L++ + ++ L ++C + L T + D L+
Sbjct: 132 LGALAEGCPRLQRLSLAHCDWVDGLALRGLADRCPALEELDLTACRQLKDEAIVYLAQRR 191
Query: 399 ACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSP-LKQLTVLN 457
LR + N V DA+ + + +N P L H+ + C + +R+L+ L L
Sbjct: 192 GAGLRSLSLAVNANVGDAAVQELARNCPELHHLDLTGCLRVGSDGVRTLAEYCPVLRSLR 251
Query: 458 LANCVRIGDMGLKQ 471
+ +C + + L +
Sbjct: 252 VRHCHHVAESSLSR 265
Score = 48.5 bits (114), Expect = 2e-05
Identities = 42/168 (25%), Positives = 74/168 (44%), Gaps = 5/168 (2%)
Query: 207 IPDKYIVSTLQRW-RLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRH 265
+ D+ +V L R +L + L G L R C LQ L+++ C ++R
Sbjct: 101 LSDEDLVPVLARNPQLRSVALGGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRG 160
Query: 266 ISEGCPGVLCLNLS--NTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGC 323
+++ CP + L+L+ + L R L++LSLA D +Q L C
Sbjct: 161 LADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDAAVQ--ELARNC 218
Query: 324 HKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKAL 371
+L +LDL+GC ++ G R +A C + L + + ++ + L
Sbjct: 219 PELHHLDLTGCLRVGSDGVRTLAEYCPVLRSLRVRHCHHVAESSLSRL 266
Score = 45.8 bits (107), Expect = 1e-04
Identities = 34/152 (22%), Positives = 67/152 (44%), Gaps = 2/152 (1%)
Query: 247 LQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTT-ITNRTMRLLPRHFHNLQNLSLAY 305
L+ + + C + ++ ++EGCP + L+L++ + +R L L+ L L
Sbjct: 116 LRSVALGGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRGLADRCPALEELDLTA 175
Query: 306 CRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTD 365
CR+ D+ + YL G L L L+ + + +A +C + HL + +
Sbjct: 176 CRQLKDEAIVYLAQRRGAG-LRSLSLAVNANVGDAAVQELARNCPELHHLDLTGCLRVGS 234
Query: 366 NCVKALVEKCSRITSLVFTGAPHISDCTFRAL 397
+ V+ L E C + SL H+++ + L
Sbjct: 235 DGVRTLAEYCPVLRSLRVRHCHHVAESSLSRL 266
>gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens]
Length = 223
Score = 63.9 bits (154), Expect = 5e-10
Identities = 37/132 (28%), Positives = 71/132 (53%), Gaps = 1/132 (0%)
Query: 554 KKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSI 613
+ L+EL ++ C ++TD + A L L L +S +L+D + A+A C +L L++
Sbjct: 75 RALQELDLTACSKLTDASL-AKVLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLAL 133
Query: 614 AGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISK 673
+ C +++D ++ L L++S C L +Q L+ + C+QLR+L + C I+
Sbjct: 134 SHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGINM 193
Query: 674 KAAQRMSSKVQQ 685
A +R +++ Q
Sbjct: 194 AAVRRFQAQLPQ 205
Score = 52.0 bits (123), Expect = 2e-06
Identities = 39/155 (25%), Positives = 66/155 (42%), Gaps = 28/155 (18%)
Query: 245 RNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSLA 304
R LQEL+++ C TD S+ + + F L+ LSL+
Sbjct: 75 RALQELDLTACSKLTDASLAKVLQ--------------------------FLQLRQLSLS 108
Query: 305 YCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLT 364
TD GL + + GC L +L LS C+++S +G+ A+S + HL ++ L
Sbjct: 109 LLPELTDNGL--VAVARGCPSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLI 166
Query: 365 DNCVKALVEKCSRITSLVFTGAPHISDCTFRALSA 399
+ + A+ + C ++ L P I+ R A
Sbjct: 167 EQTLDAIGQACRQLRVLDVATCPGINMAAVRRFQA 201
Score = 50.1 bits (118), Expect = 7e-06
Identities = 39/168 (23%), Positives = 73/168 (43%), Gaps = 26/168 (15%)
Query: 423 KNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIR 482
K+ P L H + SL L+ L L+L C ++ D L + L +++R
Sbjct: 47 KSRPELEHQASGTKDACPEPQGPSLLTLRALQELDLTACSKLTDASLAKVLQ---FLQLR 103
Query: 483 ELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDI 542
+L+LS L+D ++ ++ CP+L +L+L +C L+ +G
Sbjct: 104 QLSLSLLPELTDNGLVAVARGCPSLEHLALSHCSRLSDKG-------------------- 143
Query: 543 SNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYC 590
S +L+ L++S C ++ + + A ++ L LDV+ C
Sbjct: 144 ---WAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATC 188
Score = 44.3 bits (103), Expect = 4e-04
Identities = 31/140 (22%), Positives = 70/140 (50%), Gaps = 8/140 (5%)
Query: 378 ITSLVFTGAPHISDCTF-RALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADC 436
+ L T ++D + + L +LR++ +TD + + P+L H+ ++ C
Sbjct: 77 LQELDLTACSKLTDASLAKVLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSHC 136
Query: 437 KGITDSS-LRSLSPLKQLTVLNLANCVRIGDMGLKQFLD--GPASMRIRELNLSNCVRLS 493
++D ++ S +L LNL++C ++ ++Q LD G A ++R L+++ C ++
Sbjct: 137 SRLSDKGWAQAASSWPRLQHLNLSSCSQL----IEQTLDAIGQACRQLRVLDVATCPGIN 192
Query: 494 DASVMKLSERCPNLNYLSLR 513
A+V + + P ++ + R
Sbjct: 193 MAAVRRFQAQLPQVSCVQSR 212
>gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens]
Length = 223
Score = 63.9 bits (154), Expect = 5e-10
Identities = 37/132 (28%), Positives = 71/132 (53%), Gaps = 1/132 (0%)
Query: 554 KKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSI 613
+ L+EL ++ C ++TD + A L L L +S +L+D + A+A C +L L++
Sbjct: 75 RALQELDLTACSKLTDASL-AKVLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLAL 133
Query: 614 AGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISK 673
+ C +++D ++ L L++S C L +Q L+ + C+QLR+L + C I+
Sbjct: 134 SHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGINM 193
Query: 674 KAAQRMSSKVQQ 685
A +R +++ Q
Sbjct: 194 AAVRRFQAQLPQ 205
Score = 52.0 bits (123), Expect = 2e-06
Identities = 39/155 (25%), Positives = 66/155 (42%), Gaps = 28/155 (18%)
Query: 245 RNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSLA 304
R LQEL+++ C TD S+ + + F L+ LSL+
Sbjct: 75 RALQELDLTACSKLTDASLAKVLQ--------------------------FLQLRQLSLS 108
Query: 305 YCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLT 364
TD GL + + GC L +L LS C+++S +G+ A+S + HL ++ L
Sbjct: 109 LLPELTDNGL--VAVARGCPSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLI 166
Query: 365 DNCVKALVEKCSRITSLVFTGAPHISDCTFRALSA 399
+ + A+ + C ++ L P I+ R A
Sbjct: 167 EQTLDAIGQACRQLRVLDVATCPGINMAAVRRFQA 201
Score = 50.1 bits (118), Expect = 7e-06
Identities = 39/168 (23%), Positives = 73/168 (43%), Gaps = 26/168 (15%)
Query: 423 KNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIR 482
K+ P L H + SL L+ L L+L C ++ D L + L +++R
Sbjct: 47 KSRPELEHQASGTKDACPEPQGPSLLTLRALQELDLTACSKLTDASLAKVLQ---FLQLR 103
Query: 483 ELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDI 542
+L+LS L+D ++ ++ CP+L +L+L +C L+ +G
Sbjct: 104 QLSLSLLPELTDNGLVAVARGCPSLEHLALSHCSRLSDKG-------------------- 143
Query: 543 SNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYC 590
S +L+ L++S C ++ + + A ++ L LDV+ C
Sbjct: 144 ---WAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATC 188
Score = 44.3 bits (103), Expect = 4e-04
Identities = 31/140 (22%), Positives = 70/140 (50%), Gaps = 8/140 (5%)
Query: 378 ITSLVFTGAPHISDCTF-RALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADC 436
+ L T ++D + + L +LR++ +TD + + P+L H+ ++ C
Sbjct: 77 LQELDLTACSKLTDASLAKVLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSHC 136
Query: 437 KGITDSS-LRSLSPLKQLTVLNLANCVRIGDMGLKQFLD--GPASMRIRELNLSNCVRLS 493
++D ++ S +L LNL++C ++ ++Q LD G A ++R L+++ C ++
Sbjct: 137 SRLSDKGWAQAASSWPRLQHLNLSSCSQL----IEQTLDAIGQACRQLRVLDVATCPGIN 192
Query: 494 DASVMKLSERCPNLNYLSLR 513
A+V + + P ++ + R
Sbjct: 193 MAAVRRFQAQLPQVSCVQSR 212
>gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [Homo
sapiens]
Length = 1265
Score = 58.5 bits (140), Expect = 2e-08
Identities = 63/251 (25%), Positives = 102/251 (40%), Gaps = 39/251 (15%)
Query: 164 LQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIP-------DKYIVSTL 216
+ +F YLS +D+ +C +V W LW ID + K++ P + VS
Sbjct: 1002 MAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLD 1061
Query: 217 QRW-------------RLNVLR-LNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDES 262
W RL LR L GC + S C L+ L+V D
Sbjct: 1062 LSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQ 1121
Query: 263 MRHI----SEGCPG----------VLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRR 308
MR + ++ PG ++ L L+ IT+ ++RL+ RH L L L+YC
Sbjct: 1122 MRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNH 1181
Query: 309 FTDKGLQYLN-LGNGCH-KLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLT-D 365
TD+ + L +G L ++LS C +++ Q + C I H+ + +T +
Sbjct: 1182 VTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFF-KRCGNICHIDLRYCKQVTKE 1240
Query: 366 NCVKALVEKCS 376
C + + E S
Sbjct: 1241 GCEQFIAEMSS 1251
Score = 51.2 bits (121), Expect = 3e-06
Identities = 51/218 (23%), Positives = 96/218 (44%), Gaps = 38/218 (17%)
Query: 329 LDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPH 388
L LSGC+ I+V ++SC + L + + L D ++ L+ + P
Sbjct: 1085 LVLSGCSWIAVSAL--CSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPT-------DNRPG 1135
Query: 389 ISDCTFRALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS 448
D + + +LR + +TDAS + I ++ P LS ++++ C +TD S+ L+
Sbjct: 1136 QMDNRSKLRNIVELRLAGLD----ITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLT 1191
Query: 449 PLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLN 508
+ T +L E+NLS+C +++D + +RC N+
Sbjct: 1192 AVGTTTRDSLT-----------------------EINLSDCNKVTD-QCLSFFKRCGNIC 1227
Query: 509 YLSLRNCEHLTAQGI-GYIVNIFSLVSIDLSGTDISNE 545
++ LR C+ +T +G +I + S S T + +E
Sbjct: 1228 HIDLRYCKQVTKEGCEQFIAEMSSFQGRSCSTTRLGDE 1265
Score = 48.1 bits (113), Expect = 3e-05
Identities = 47/194 (24%), Positives = 83/194 (42%), Gaps = 34/194 (17%)
Query: 413 VTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS-PLKQLTVLNLANCVRIGDMGLKQ 471
++ ++ P L + ++ C I S+L S S PL L L++ + D ++
Sbjct: 1067 ISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPL--LRTLDVQWVEGLKDAQMRD 1124
Query: 472 FLDGPASMRIRELN----LSNCVRL-------SDASVMKLSERCPNLNYLSLRNCEHLTA 520
L P R +++ L N V L +DAS+ + P L+ L L C H+T
Sbjct: 1125 LLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTD 1184
Query: 521 QGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSL 580
Q I + + GT + L E+++S+C ++TD + F +
Sbjct: 1185 QSINLLTAV---------GT----------TTRDSLTEINLSDCNKVTDQCLSFFKRCGN 1225
Query: 581 ILEHLDVSYCSQLS 594
I H+D+ YC Q++
Sbjct: 1226 IC-HIDLRYCKQVT 1238
Score = 40.4 bits (93), Expect = 0.006
Identities = 41/183 (22%), Positives = 83/183 (45%), Gaps = 24/183 (13%)
Query: 481 IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGT 540
+R+L LS C ++ +++ S CP L L ++ E L + +++ T
Sbjct: 1082 LRDLVLSGCSWIAVSALC--SSSCPLLRTLDVQWVEGLKDAQMRDLLS---------PPT 1130
Query: 541 DISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKA 600
D ++ S+ + + EL ++ ITD ++ + +L L +SYC+ ++D I
Sbjct: 1131 DNRPGQMDNRSKLRNIVELRLAGL-DITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINL 1189
Query: 601 LAIYCI----NLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIG 656
L +LT ++++ C K+TD + +C + +D+ C +T + G
Sbjct: 1190 LTAVGTTTRDSLTEINLSDCNKVTDQCLSFFK-RCGNICHIDLRYCKQVTKE-------G 1241
Query: 657 CKQ 659
C+Q
Sbjct: 1242 CEQ 1244
>gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [Homo
sapiens]
Length = 1336
Score = 57.8 bits (138), Expect = 4e-08
Identities = 62/248 (25%), Positives = 101/248 (40%), Gaps = 39/248 (15%)
Query: 164 LQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIP-------DKYIVSTL 216
+ +F YLS +D+ +C +V W LW ID + K++ P + VS
Sbjct: 1071 MAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLD 1130
Query: 217 QRW-------------RLNVLR-LNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDES 262
W RL LR L GC + S C L+ L+V D
Sbjct: 1131 LSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQ 1190
Query: 263 MRHI----SEGCPG----------VLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRR 308
MR + ++ PG ++ L L+ IT+ ++RL+ RH L L L+YC
Sbjct: 1191 MRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNH 1250
Query: 309 FTDKGLQYLN-LGNGCH-KLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLT-D 365
TD+ + L +G L ++LS C +++ Q + C I H+ + +T +
Sbjct: 1251 VTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFF-KRCGNICHIDLRYCKQVTKE 1309
Query: 366 NCVKALVE 373
C + + E
Sbjct: 1310 GCEQFIAE 1317
Score = 50.4 bits (119), Expect = 6e-06
Identities = 46/194 (23%), Positives = 87/194 (44%), Gaps = 37/194 (19%)
Query: 329 LDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPH 388
L LSGC+ I+V ++SC + L + + L D ++ L+ + P
Sbjct: 1154 LVLSGCSWIAVSAL--CSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPT-------DNRPG 1204
Query: 389 ISDCTFRALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS 448
D + + +LR + +TDAS + I ++ P LS ++++ C +TD S+ L+
Sbjct: 1205 QMDNRSKLRNIVELRLAGLD----ITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLT 1260
Query: 449 PLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLN 508
+ T +L E+NLS+C +++D + +RC N+
Sbjct: 1261 AVGTTTRDSLT-----------------------EINLSDCNKVTD-QCLSFFKRCGNIC 1296
Query: 509 YLSLRNCEHLTAQG 522
++ LR C+ +T +G
Sbjct: 1297 HIDLRYCKQVTKEG 1310
Score = 48.1 bits (113), Expect = 3e-05
Identities = 47/194 (24%), Positives = 83/194 (42%), Gaps = 34/194 (17%)
Query: 413 VTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS-PLKQLTVLNLANCVRIGDMGLKQ 471
++ ++ P L + ++ C I S+L S S PL L L++ + D ++
Sbjct: 1136 ISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPL--LRTLDVQWVEGLKDAQMRD 1193
Query: 472 FLDGPASMRIRELN----LSNCVRL-------SDASVMKLSERCPNLNYLSLRNCEHLTA 520
L P R +++ L N V L +DAS+ + P L+ L L C H+T
Sbjct: 1194 LLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTD 1253
Query: 521 QGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSL 580
Q I + + GT + L E+++S+C ++TD + F +
Sbjct: 1254 QSINLLTAV---------GT----------TTRDSLTEINLSDCNKVTDQCLSFFKRCGN 1294
Query: 581 ILEHLDVSYCSQLS 594
I H+D+ YC Q++
Sbjct: 1295 IC-HIDLRYCKQVT 1307
Score = 40.8 bits (94), Expect = 0.005
Identities = 46/207 (22%), Positives = 93/207 (44%), Gaps = 28/207 (13%)
Query: 481 IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGT 540
+R+L LS C ++ +++ S CP L L ++ E L + +++ T
Sbjct: 1151 LRDLVLSGCSWIAVSALC--SSSCPLLRTLDVQWVEGLKDAQMRDLLS---------PPT 1199
Query: 541 DISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKA 600
D ++ S+ + + EL ++ ITD ++ + +L L +SYC+ ++D I
Sbjct: 1200 DNRPGQMDNRSKLRNIVELRLAGL-DITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINL 1258
Query: 601 LAIYCI----NLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIG 656
L +LT ++++ C K+TD + +C + +D+ C +T + G
Sbjct: 1259 LTAVGTTTRDSLTEINLSDCNKVTDQCLSFFK-RCGNICHIDLRYCKQVTKE-------G 1310
Query: 657 CKQLRILKMQYCT---NISKKAAQRMS 680
C+Q I +M + +K Q++S
Sbjct: 1311 CEQF-IAEMSVSVQFGQVEEKLLQKLS 1336
>gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo
sapiens]
Length = 424
Score = 55.1 bits (131), Expect = 2e-07
Identities = 94/401 (23%), Positives = 156/401 (38%), Gaps = 85/401 (21%)
Query: 121 KNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQ 180
K+ +I++R NFP S LP+ +L IF L L +++
Sbjct: 77 KDFVIVRRPKLNRENFPGVSWDS--------------LPDELLLGIFSCLCLPELLKVSG 122
Query: 181 VNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRS 240
V W + SLW +D + KN+ PD RL +G + FR
Sbjct: 123 VCKRWYRLASDESLWQTLDLTG-KNLHPDV------------TGRLLSQGVI----AFR- 164
Query: 241 VSHCRNLQELNVSDCP-TFTDESM-RHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNL 298
CP +F D+ + H S V ++LSN+ I T+ + L
Sbjct: 165 --------------CPRSFMDQPLAEHFSPF--RVQHMDLSNSVIEVSTLHGILSQCSKL 208
Query: 299 QNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTIN 358
QNLSL R +D + L + L+ L+LSGC+ S + + +SC+ + L ++
Sbjct: 209 QNLSLEGLR-LSDPIVNTLAKNSN---LVRLNLSGCSGFSEFALQTLLSSCSRLDELNLS 264
Query: 359 DMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASF 418
T+ V+ V H+S+ T L+ RK N + +D S
Sbjct: 265 WCFDFTEKHVQVAV--------------AHVSE-TITQLNLSGYRK-----NLQKSDLS- 303
Query: 419 KFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPAS 478
+ + PNL H+ ++D + + + L L L+L+ C I L + + P
Sbjct: 304 -TLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTL 362
Query: 479 MRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLT 519
++ + + D ++ L E P+L NC H T
Sbjct: 363 KTLQVFGI-----VPDGTLQLLKEALPHLQI----NCSHFT 394
Score = 48.9 bits (115), Expect = 2e-05
Identities = 36/150 (24%), Positives = 74/150 (49%), Gaps = 3/150 (2%)
Query: 524 GYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILE 583
G + L ++ L G +S+ +N L+++ L L++S C ++ +Q S L+
Sbjct: 200 GILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLD 259
Query: 584 HLDVSYCSQLSDMIIK-ALAIYCINLTSLSIAGCPK-ITDSAMEMLSAKCHYLHILDISG 641
L++S+C ++ ++ A+A +T L+++G K + S + L +C L LD+S
Sbjct: 260 ELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSD 319
Query: 642 CVLLTDQILEDLQIGCKQLRILKMQYCTNI 671
V+L + ++ L+ L + C +I
Sbjct: 320 SVMLKNDCFQEF-FQLNYLQHLSLSRCYDI 348
Score = 38.9 bits (89), Expect = 0.017
Identities = 40/158 (25%), Positives = 70/158 (44%), Gaps = 9/158 (5%)
Query: 484 LNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFS--LVSIDLSG-- 539
LNLS C S+ ++ L C L+ L+L C T + + V S + ++LSG
Sbjct: 235 LNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYR 294
Query: 540 TDISNEGLNVLSRH-KKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMII 598
++ L+ L R L L +S+ + +D Q F + + L+HL +S C + +
Sbjct: 295 KNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLN-YLQHLSLSRCYDIIPETL 353
Query: 599 KALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHI 636
L L +L + G + D +++L +L I
Sbjct: 354 LELG-EIPTLKTLQVFGI--VPDGTLQLLKEALPHLQI 388
Score = 36.2 bits (82), Expect = 0.11
Identities = 26/96 (27%), Positives = 50/96 (52%), Gaps = 3/96 (3%)
Query: 582 LEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISG 641
++H+D+S S + + + C L +LS+ G +++D + L AK L L++SG
Sbjct: 183 VQHMDLSN-SVIEVSTLHGILSQCSKLQNLSLEGL-RLSDPIVNTL-AKNSNLVRLNLSG 239
Query: 642 CVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQ 677
C ++ L+ L C +L L + +C + ++K Q
Sbjct: 240 CSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQ 275
>gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens]
Length = 1162
Score = 53.9 bits (128), Expect = 5e-07
Identities = 71/284 (25%), Positives = 106/284 (37%), Gaps = 71/284 (25%)
Query: 154 DISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKY-- 211
D S + + +F YLS +++ C +V W LW ID S K ++P
Sbjct: 889 DESWMQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSG 948
Query: 212 ---------------IVSTLQRWRLNVL----RLNFRGCLLRPKTFRSVSHCRNLQELNV 252
I W +N L L GC + S S C L+ L++
Sbjct: 949 IIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDL 1008
Query: 253 SDCPTFTDESMRHI---SEGCPG---------VLCLNLSNTTITNRTMRLLPRHFHNLQN 300
D +R + PG + L+ IT+ T+RL+ RH L
Sbjct: 1009 RWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSR 1068
Query: 301 LSLAYCRRFTDK--------------GLQYLNLGNGCHK-----LIYL---------DLS 332
L L++C TD+ L LN+ GC+K LIYL DL
Sbjct: 1069 LDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMA-GCNKLTDQTLIYLRRIANVTLIDLR 1127
Query: 333 GCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCS 376
GC QI+ + + I L+IN + L+D + L++K S
Sbjct: 1128 GCKQITRKACEHF------ISDLSINSLYCLSD---EKLIQKIS 1162
Score = 46.2 bits (108), Expect = 1e-04
Identities = 57/249 (22%), Positives = 102/249 (40%), Gaps = 28/249 (11%)
Query: 428 LSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLS 487
LS + +C + + + + T ++L+ C I + Q L G + L+LS
Sbjct: 905 LSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAI----VPQALSGIIKRQPVSLDLS 960
Query: 488 NCVRLSDASVMKLSERCPNL-------------NYLSLRNCEHLTAQGIGYIVNIFSLVS 534
+S + L R P L + LS +C L + + V I
Sbjct: 961 -WTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQI 1019
Query: 535 IDLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLS 594
DL G + S+ + + + ++ ITD ++ + +L LD+S+CS L+
Sbjct: 1020 RDLLTPPADKPGQDNRSKLRNMTDFRLAGL-DITDATLRLIIRHMPLLSRLDLSHCSHLT 1078
Query: 595 DMIIKALAIYC----INLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLT---- 646
D L +LT L++AGC K+TD + L + + ++D+ GC +T
Sbjct: 1079 DQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYL-RRIANVTLIDLRGCKQITRKAC 1137
Query: 647 DQILEDLQI 655
+ + DL I
Sbjct: 1138 EHFISDLSI 1146
Score = 46.2 bits (108), Expect = 1e-04
Identities = 54/224 (24%), Positives = 94/224 (41%), Gaps = 44/224 (19%)
Query: 327 IYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKAL-VEKCSRITSLVFTG 385
+ LDLS T IS + ++ N G+ L + + V AL C + +L
Sbjct: 955 VSLDLSW-TNISKKQLTWLVNRLPGLKDLLLAGCSW---SAVSALSTSSCPLLRTLDLRW 1010
Query: 386 APHISDCTFRAL-----------SACKLRKI---RFEGNKRVTDASFKFIDKNYPNLSHI 431
A I D R L + KLR + R G +TDA+ + I ++ P LS +
Sbjct: 1011 AVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLD-ITDATLRLIIRHMPLLSRL 1069
Query: 432 YMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVR 491
++ C +TD S L+ + T +L ELN++ C +
Sbjct: 1070 DLSHCSHLTDQSSNLLTAVGSSTRYSLT-----------------------ELNMAGCNK 1106
Query: 492 LSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSI 535
L+D +++ L R N+ + LR C+ +T + + ++ S+ S+
Sbjct: 1107 LTDQTLIYL-RRIANVTLIDLRGCKQITRKACEHFISDLSINSL 1149
Score = 42.4 bits (98), Expect = 0.002
Identities = 53/234 (22%), Positives = 92/234 (39%), Gaps = 62/234 (26%)
Query: 426 PNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASM-----R 480
P L + +A C S+L S S L L+L V I D ++ L PA R
Sbjct: 977 PGLKDLLLAGCSWSAVSAL-STSSCPLLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNR 1035
Query: 481 IRELNLSNC----VRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSID 536
+ N+++ + ++DA++ + P L+ L L +C HLT Q + + S
Sbjct: 1036 SKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGS----- 1090
Query: 537 LSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDM 596
S L EL+++ C ++TD + +
Sbjct: 1091 --------------STRYSLTELNMAGCNKLTDQTL-----------------------I 1113
Query: 597 IIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQIL 650
++ +A N+T + + GC +IT A E H++ L I+ L+D+ L
Sbjct: 1114 YLRRIA----NVTLIDLRGCKQITRKACE------HFISDLSINSLYCLSDEKL 1157
Score = 34.7 bits (78), Expect = 0.33
Identities = 54/258 (20%), Positives = 101/258 (39%), Gaps = 37/258 (14%)
Query: 249 ELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRR 308
++++S C +++ I + P + L+LS T I+ + + L L++L LA C
Sbjct: 932 KIDLSRCKAIVPQALSGIIKRQP--VSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGC-- 987
Query: 309 FTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTL-TDNC 367
+ L S C + R+ GI I D+ T D
Sbjct: 988 -------------SWSAVSALSTSSCPLLRTLDLRW----AVGIKDPQIRDLLTPPADKP 1030
Query: 368 VKALVEKCSRITSLVFTGAPHISDCTFRALSACK--LRKIRFEGNKRVTDASFKFI---- 421
+ K +T G I+D T R + L ++ +TD S +
Sbjct: 1031 GQDNRSKLRNMTDFRLAGLD-ITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVG 1089
Query: 422 DKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRI 481
+L+ + MA C +TD +L L + +T+++L C +I + F I
Sbjct: 1090 SSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHF--------I 1141
Query: 482 RELNLSNCVRLSDASVMK 499
+L++++ LSD +++
Sbjct: 1142 SDLSINSLYCLSDEKLIQ 1159
>gi|16306576 F-box and leucine-rich repeat protein 6 isoform 1 [Homo
sapiens]
Length = 539
Score = 51.6 bits (122), Expect = 3e-06
Identities = 58/243 (23%), Positives = 94/243 (38%), Gaps = 37/243 (15%)
Query: 290 LLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSC 349
L+P F LQ L+L + + L+ + G C +L +L LSGC ++ +A +C
Sbjct: 188 LMPNRFSQLQRLTLIHWKSQVHPVLKLV--GECCPRLTFLKLSGCHGVTADALVMLAKAC 245
Query: 350 TGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEG 409
+ L + + V L E SR+ L T + + L +C
Sbjct: 246 CQLHSLDLQHSMVESTAVVSFLEEAGSRMRKLWLTYSSQTTAILGALLGSC--------- 296
Query: 410 NKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLK-------QLTVLNLANCV 462
P L + ++ GI +S+ P++ QL VL L N +
Sbjct: 297 ---------------CPQLQVLEVST--GINRNSIPLQLPVEALQKGCPQLQVLRLLNLM 339
Query: 463 RIGDMGLKQFLDGPASMRIRELNL--SNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTA 520
+ + GP + EL L S C +S+ + +L PNL L LR C +T
Sbjct: 340 WLPKPPGRGVAPGPGFPSLEELCLASSTCNFVSNEVLGRLLHGSPNLRLLDLRGCARITP 399
Query: 521 QGI 523
G+
Sbjct: 400 AGL 402
Score = 40.0 bits (92), Expect = 0.008
Identities = 22/86 (25%), Positives = 43/86 (50%)
Query: 582 LEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISG 641
L+ L + + ++K + C LT L ++GC +T A+ ML+ C LH LD+
Sbjct: 196 LQRLTLIHWKSQVHPVLKLVGECCPRLTFLKLSGCHGVTADALVMLAKACCQLHSLDLQH 255
Query: 642 CVLLTDQILEDLQIGCKQLRILKMQY 667
++ + ++ L+ ++R L + Y
Sbjct: 256 SMVESTAVVSFLEEAGSRMRKLWLTY 281
Score = 31.6 bits (70), Expect = 2.8
Identities = 51/217 (23%), Positives = 85/217 (39%), Gaps = 26/217 (11%)
Query: 497 VMKL-SERCPNLNYLSLRNCEHLTAQGIGYIVNIF-SLVSIDLSGTDISNEGL-----NV 549
V+KL E CP L +L L C +TA + + L S+DL + + + +
Sbjct: 211 VLKLVGECCPRLTFLKLSGCHGVTADALVMLAKACCQLHSLDLQHSMVESTAVVSFLEEA 270
Query: 550 LSRHKKLKELSVSECYRITDDGIQAFCKSSLILE-HLDVSYCSQLSDMIIKALAIYCINL 608
SR +KL S+ I + + C +LE ++ S + ++AL C L
Sbjct: 271 GSRMRKLWLTYSSQTTAILGALLGSCCPQLQVLEVSTGINRNSIPLQLPVEALQKGCPQL 330
Query: 609 TSLSIAGC---PK------ITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQ 659
L + PK L C L S C +++++L L G
Sbjct: 331 QVLRLLNLMWLPKPPGRGVAPGPGFPSLEELC-----LASSTCNFVSNEVLGRLLHGSPN 385
Query: 660 LRILKMQYCTNISKKAAQRMSSKVQQQ----EYNTND 692
LR+L ++ C I+ Q + + +Q Y T+D
Sbjct: 386 LRLLDLRGCARITPAGLQDLPCRELEQLHLGLYGTSD 422
>gi|157168349 F-box and leucine-rich repeat protein 19 [Homo
sapiens]
Length = 694
Score = 51.6 bits (122), Expect = 3e-06
Identities = 52/221 (23%), Positives = 93/221 (42%), Gaps = 43/221 (19%)
Query: 158 LPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQ 217
LP A L++F +L +++ IC +V W LW +D S K++ P ++S +
Sbjct: 424 LPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPP--MLSGVV 481
Query: 218 RWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFT------------------ 259
R + L L++ G + + + ++ + LQEL +S C +
Sbjct: 482 RRQPRALDLSWTG-VSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLR 540
Query: 260 ------DESMRHI-------------SEG-CPGVLCLNLSNTTITNRTMRLLPRHFHNLQ 299
D +R + S G GV L L+ +T+ ++RLL RH L
Sbjct: 541 WIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLS 600
Query: 300 NLSLAYCRRFTDKGLQYLNLGNG--CHKLIYLDLSGCTQIS 338
L L++C D + L L++L+L+GC +++
Sbjct: 601 ALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLT 641
Score = 48.1 bits (113), Expect = 3e-05
Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 8/98 (8%)
Query: 413 VTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSL----SPLKQLTV-LNLANCVRIGDM 467
+TDAS + + ++ P LS + ++ C + D S+ L SPL++ V LNLA C R+ D
Sbjct: 584 LTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDH 643
Query: 468 GLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCP 505
L F P R+R L+L +C +LS + +L+ P
Sbjct: 644 CLPLFRRCP---RLRRLDLRSCRQLSPEACARLAAAGP 678
Score = 42.0 bits (97), Expect = 0.002
Identities = 47/187 (25%), Positives = 80/187 (42%), Gaps = 34/187 (18%)
Query: 428 LSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMR------- 480
L + ++ C ++ S+L S +PL L +L+L + D L++ L P +
Sbjct: 510 LQELVLSGCSWLSVSALGS-APLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESR 568
Query: 481 -----IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSI 535
+ EL L+ + L+DAS+ L P L+ L L +C H+ V++ + +
Sbjct: 569 GRLQGVAELRLAG-LELTDASLRLLLRHAPQLSALDLSHCAHVGDPS----VHLLTAPTS 623
Query: 536 DLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSD 595
L T L L+++ C+R+TD + F + L LD+ C QLS
Sbjct: 624 PLRET---------------LVHLNLAGCHRLTDHCLPLFRRCPR-LRRLDLRSCRQLSP 667
Query: 596 MIIKALA 602
LA
Sbjct: 668 EACARLA 674
Score = 38.5 bits (88), Expect = 0.023
Identities = 48/196 (24%), Positives = 82/196 (41%), Gaps = 24/196 (12%)
Query: 473 LDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSL 532
L G + R L+LS +S +M L R L L L C L+ +G + +L
Sbjct: 477 LSGVVRRQPRALDLS-WTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGS-APLPAL 534
Query: 533 VSIDLSGT-DISNEGLNVL---------------SRHKKLKELSVSECYRITDDGIQAFC 576
+DL D+ + L L R + + EL ++ +TD ++
Sbjct: 535 RLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGL-ELTDASLRLLL 593
Query: 577 KSSLILEHLDVSYCSQLSDMIIKALAIYCI----NLTSLSIAGCPKITDSAMEMLSAKCH 632
+ + L LD+S+C+ + D + L L L++AGC ++TD + L +C
Sbjct: 594 RHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLP-LFRRCP 652
Query: 633 YLHILDISGCVLLTDQ 648
L LD+ C L+ +
Sbjct: 653 RLRRLDLRSCRQLSPE 668
Score = 30.4 bits (67), Expect = 6.1
Identities = 41/192 (21%), Positives = 81/192 (42%), Gaps = 47/192 (24%)
Query: 534 SIDLSGTDISNEGLN-VLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQ 592
++DLS T +S + L +L+R + L+EL +S C ++ + + +L L LD+ +
Sbjct: 487 ALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRL--LDLRWIED 544
Query: 593 LSDMIIKALAI--------------YCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILD 638
+ D ++ L + + L +AG ++TD+++ +L L LD
Sbjct: 545 VKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGL-ELTDASLRLLLRHAPQLSALD 603
Query: 639 ISGCVLLTD--------------QILEDLQIG---------------CKQLRILKMQYCT 669
+S C + D + L L + C +LR L ++ C
Sbjct: 604 LSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCR 663
Query: 670 NISKKAAQRMSS 681
+S +A R+++
Sbjct: 664 QLSPEACARLAA 675
>gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo
sapiens]
Length = 410
Score = 51.2 bits (121), Expect = 3e-06
Identities = 95/400 (23%), Positives = 158/400 (39%), Gaps = 80/400 (20%)
Query: 121 KNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQ 180
K+ +I++R NFP S LP+ +L IF L L +++
Sbjct: 77 KDFVIVRRPKLNRENFPGVSWDS--------------LPDELLLGIFSCLCLPELLKVSG 122
Query: 181 VNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRS 240
V W + SLW +D + KN+ PD RL +G + FR
Sbjct: 123 VCKRWYRLASDESLWQTLDLTG-KNLHPDV------------TGRLLSQGVI----AFR- 164
Query: 241 VSHCRNLQELNVSDCP-TFTDESM-RHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNL 298
CP +F D+ + H S V ++LSN+ I T+ + L
Sbjct: 165 --------------CPRSFMDQPLAEHFSPF--RVQHMDLSNSVIEVSTLHGILSQCSKL 208
Query: 299 QNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTIN 358
QNLSL R +D + L + L+ L+LSGC+ S + + +SC+ + L ++
Sbjct: 209 QNLSLEGLR-LSDPIVNTLAKNSN---LVRLNLSGCSGFSEFALQTLLSSCSRLDELNLS 264
Query: 359 DMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASF 418
T+ V+ V H+S+ T L+ RK N + +D S
Sbjct: 265 WCFDFTEKHVQVAV--------------AHVSE-TITQLNLSGYRK-----NLQKSDLS- 303
Query: 419 KFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPAS 478
+ + PNL H+ ++D + + + L L L+L+ C I L L A
Sbjct: 304 -TLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETL--LLVTRAG 360
Query: 479 MRIRELNLSNCVRLSDASVMKLSER--CPNLNYLSLRNCE 516
+RIR + C + S +K S + C ++ + + C+
Sbjct: 361 VRIRLDSDIGCPQTYRTSKLKSSHKLFCQHVRVICIFVCD 400
Score = 48.9 bits (115), Expect = 2e-05
Identities = 36/150 (24%), Positives = 74/150 (49%), Gaps = 3/150 (2%)
Query: 524 GYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILE 583
G + L ++ L G +S+ +N L+++ L L++S C ++ +Q S L+
Sbjct: 200 GILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLD 259
Query: 584 HLDVSYCSQLSDMIIK-ALAIYCINLTSLSIAGCPK-ITDSAMEMLSAKCHYLHILDISG 641
L++S+C ++ ++ A+A +T L+++G K + S + L +C L LD+S
Sbjct: 260 ELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSD 319
Query: 642 CVLLTDQILEDLQIGCKQLRILKMQYCTNI 671
V+L + ++ L+ L + C +I
Sbjct: 320 SVMLKNDCFQEF-FQLNYLQHLSLSRCYDI 348
Score = 42.7 bits (99), Expect = 0.001
Identities = 41/166 (24%), Positives = 74/166 (44%), Gaps = 8/166 (4%)
Query: 484 LNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFS--LVSIDLSG-- 539
LNLS C S+ ++ L C L+ L+L C T + + V S + ++LSG
Sbjct: 235 LNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYR 294
Query: 540 TDISNEGLNVLSRH-KKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMII 598
++ L+ L R L L +S+ + +D Q F + + L+HL +S C + +
Sbjct: 295 KNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLN-YLQHLSLSRCYDIIPETL 353
Query: 599 KALAIYCINLTSLSIAGCPKITDSAMEMLSAK--CHYLHILDISGC 642
+ + + S GCP+ ++ S K C ++ ++ I C
Sbjct: 354 LLVTRAGVRIRLDSDIGCPQTYRTSKLKSSHKLFCQHVRVICIFVC 399
Score = 36.2 bits (82), Expect = 0.11
Identities = 26/96 (27%), Positives = 50/96 (52%), Gaps = 3/96 (3%)
Query: 582 LEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISG 641
++H+D+S S + + + C L +LS+ G +++D + L AK L L++SG
Sbjct: 183 VQHMDLSN-SVIEVSTLHGILSQCSKLQNLSLEGL-RLSDPIVNTL-AKNSNLVRLNLSG 239
Query: 642 CVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQ 677
C ++ L+ L C +L L + +C + ++K Q
Sbjct: 240 CSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQ 275
>gi|61742136 F-box and leucine-rich repeat protein 6 isoform 2 [Homo
sapiens]
Length = 533
Score = 49.3 bits (116), Expect = 1e-05
Identities = 57/243 (23%), Positives = 92/243 (37%), Gaps = 43/243 (17%)
Query: 290 LLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSC 349
L+P F LQ L+L + + +G C +L +L LSGC ++ +A +C
Sbjct: 188 LMPNRFSQLQRLTLIHWKSQL--------VGECCPRLTFLKLSGCHGVTADALVMLAKAC 239
Query: 350 TGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEG 409
+ L + + V L E SR+ L T + + L +C
Sbjct: 240 CQLHSLDLQHSMVESTAVVSFLEEAGSRMRKLWLTYSSQTTAILGALLGSC--------- 290
Query: 410 NKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLK-------QLTVLNLANCV 462
P L + ++ GI +S+ P++ QL VL L N +
Sbjct: 291 ---------------CPQLQVLEVST--GINRNSIPLQLPVEALQKGCPQLQVLRLLNLM 333
Query: 463 RIGDMGLKQFLDGPASMRIRELNL--SNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTA 520
+ + GP + EL L S C +S+ + +L PNL L LR C +T
Sbjct: 334 WLPKPPGRGVAPGPGFPSLEELCLASSTCNFVSNEVLGRLLHGSPNLRLLDLRGCARITP 393
Query: 521 QGI 523
G+
Sbjct: 394 AGL 396
Score = 38.9 bits (89), Expect = 0.017
Identities = 28/102 (27%), Positives = 50/102 (49%), Gaps = 5/102 (4%)
Query: 571 GIQAFCKSSLILEHLDVSYCSQLSDMII-----KALAIYCINLTSLSIAGCPKITDSAME 625
G++A K LE L + SQL + + + + C LT L ++GC +T A+
Sbjct: 174 GVKAEKKLLASLEWLMPNRFSQLQRLTLIHWKSQLVGECCPRLTFLKLSGCHGVTADALV 233
Query: 626 MLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQY 667
ML+ C LH LD+ ++ + ++ L+ ++R L + Y
Sbjct: 234 MLAKACCQLHSLDLQHSMVESTAVVSFLEEAGSRMRKLWLTY 275
Score = 30.8 bits (68), Expect = 4.7
Identities = 48/213 (22%), Positives = 82/213 (38%), Gaps = 25/213 (11%)
Query: 500 LSERCPNLNYLSLRNCEHLTAQGIGYIVNIF-SLVSIDLSGTDISNEGL-----NVLSRH 553
+ E CP L +L L C +TA + + L S+DL + + + + SR
Sbjct: 209 VGECCPRLTFLKLSGCHGVTADALVMLAKACCQLHSLDLQHSMVESTAVVSFLEEAGSRM 268
Query: 554 KKLKELSVSECYRITDDGIQAFCKSSLILE-HLDVSYCSQLSDMIIKALAIYCINLTSLS 612
+KL S+ I + + C +LE ++ S + ++AL C L L
Sbjct: 269 RKLWLTYSSQTTAILGALLGSCCPQLQVLEVSTGINRNSIPLQLPVEALQKGCPQLQVLR 328
Query: 613 IAGC---PK------ITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRIL 663
+ PK L C L S C +++++L L G LR+L
Sbjct: 329 LLNLMWLPKPPGRGVAPGPGFPSLEELC-----LASSTCNFVSNEVLGRLLHGSPNLRLL 383
Query: 664 KMQYCTNISKKAAQRMSSKVQQQ----EYNTND 692
++ C I+ Q + + +Q Y T+D
Sbjct: 384 DLRGCARITPAGLQDLPCRELEQLHLGLYGTSD 416
>gi|16306574 F-box and leucine-rich repeat protein 5 isoform 2 [Homo
sapiens]
Length = 565
Score = 45.4 bits (106), Expect = 2e-04
Identities = 27/75 (36%), Positives = 39/75 (52%), Gaps = 2/75 (2%)
Query: 608 LTSLSIAGCPKITDSAMEMLS--AKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKM 665
L LS++GC +ITD + +L+ YL L++SGC+ +T L+DL C L
Sbjct: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
Query: 666 QYCTNISKKAAQRMS 680
YC NI+ A S
Sbjct: 534 YYCDNINGPHADTAS 548
Score = 43.5 bits (101), Expect = 7e-04
Identities = 21/52 (40%), Positives = 32/52 (61%)
Query: 301 LSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGI 352
LSL+ C + TD GL+ L LG G L +L+LSGC I+ G + + ++C +
Sbjct: 477 LSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSL 528
Score = 41.2 bits (95), Expect = 0.003
Identities = 21/66 (31%), Positives = 34/66 (51%)
Query: 453 LTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSL 512
L L+L+ C +I D GL+ G + LNLS C+ ++ A + L CP+LN
Sbjct: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
Query: 513 RNCEHL 518
C+++
Sbjct: 534 YYCDNI 539
Score = 38.1 bits (87), Expect = 0.029
Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 8/98 (8%)
Query: 98 ARHKSKKKEDELILKHELQLKKWKNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISL 157
A+H S+K EL+ L + + K + E+S+ S I+
Sbjct: 30 AQHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEH--------STGITH 81
Query: 158 LPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLW 195
LP +L IF YL+ +++ C QV+ W +T+ SLW
Sbjct: 82 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLW 119
Score = 36.6 bits (83), Expect = 0.086
Identities = 24/71 (33%), Positives = 37/71 (52%), Gaps = 3/71 (4%)
Query: 585 LDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLS--AKCHYLHILDISGC 642
L ++Y S +S +++ + C NL L + I+DSA + S C L LD+SGC
Sbjct: 209 LVLAYSSAVSSKMVRQILELCPNLEHLDLTQTD-ISDSAFDSWSWLGCCQSLRHLDLSGC 267
Query: 643 VLLTDQILEDL 653
+TD LE +
Sbjct: 268 EKITDVALEKI 278
Score = 35.8 bits (81), Expect = 0.15
Identities = 35/135 (25%), Positives = 57/135 (42%), Gaps = 13/135 (9%)
Query: 321 NGCHK--LIYLDLSGCTQ--ISVQGFRYIANS--CTGIMHLTINDMPTLTDNCVKALVEK 374
+GC ++ L S C Q + F Y +S CTG T++ +P + C KA +
Sbjct: 392 SGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTR 451
Query: 375 CSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKF--IDKNYPNLSHIY 432
R L++ G+ T R L L G ++TD + + P L H+
Sbjct: 452 LPRGKDLIYFGSEKSDQETGRVLLFLSL-----SGCYQITDHGLRVLTLGGGLPYLEHLN 506
Query: 433 MADCKGITDSSLRSL 447
++ C IT + L+ L
Sbjct: 507 LSGCLTITGAGLQDL 521
Score = 33.5 bits (75), Expect = 0.73
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 6/81 (7%)
Query: 559 LSVSECYRITDDGIQAFCKSSLI--LEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGC 616
LS+S CY+ITD G++ + LEHL++S C ++ ++ L C +L C
Sbjct: 477 LSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYC 536
Query: 617 PKI----TDSAMEMLSAKCHY 633
I D+A + +C +
Sbjct: 537 DNINGPHADTASGCQNLQCGF 557
Score = 32.7 bits (73), Expect = 1.2
Identities = 19/49 (38%), Positives = 30/49 (61%), Gaps = 3/49 (6%)
Query: 582 LEHLDVSYCSQLSDMIIKALAIY--CINLTSLSIAGCPKITDSAMEMLS 628
LEHLD++ + +SD + + C +L L ++GC KITD A+E +S
Sbjct: 232 LEHLDLTQ-TDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKIS 279
Score = 32.3 bits (72), Expect = 1.6
Identities = 21/78 (26%), Positives = 35/78 (44%), Gaps = 2/78 (2%)
Query: 326 LIYLDLSGCTQISVQGFRY--IANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVF 383
L++L LSGC QI+ G R + + HL ++ T+T ++ LV C + F
Sbjct: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
Query: 384 TGAPHISDCTFRALSACK 401
+I+ S C+
Sbjct: 534 YYCDNINGPHADTASGCQ 551
>gi|16306572 F-box and leucine-rich repeat protein 5 isoform 1 [Homo
sapiens]
Length = 691
Score = 45.4 bits (106), Expect = 2e-04
Identities = 27/75 (36%), Positives = 39/75 (52%), Gaps = 2/75 (2%)
Query: 608 LTSLSIAGCPKITDSAMEMLS--AKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKM 665
L LS++GC +ITD + +L+ YL L++SGC+ +T L+DL C L
Sbjct: 600 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 659
Query: 666 QYCTNISKKAAQRMS 680
YC NI+ A S
Sbjct: 660 YYCDNINGPHADTAS 674
Score = 43.5 bits (101), Expect = 7e-04
Identities = 21/52 (40%), Positives = 32/52 (61%)
Query: 301 LSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGI 352
LSL+ C + TD GL+ L LG G L +L+LSGC I+ G + + ++C +
Sbjct: 603 LSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSL 654
Score = 41.2 bits (95), Expect = 0.003
Identities = 21/66 (31%), Positives = 34/66 (51%)
Query: 453 LTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSL 512
L L+L+ C +I D GL+ G + LNLS C+ ++ A + L CP+LN
Sbjct: 600 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 659
Query: 513 RNCEHL 518
C+++
Sbjct: 660 YYCDNI 665
Score = 38.1 bits (87), Expect = 0.029
Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 8/98 (8%)
Query: 98 ARHKSKKKEDELILKHELQLKKWKNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISL 157
A+H S+K EL+ L + + K + E+S+ S I+
Sbjct: 156 AQHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEH--------STGITH 207
Query: 158 LPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLW 195
LP +L IF YL+ +++ C QV+ W +T+ SLW
Sbjct: 208 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLW 245
Score = 36.6 bits (83), Expect = 0.086
Identities = 24/71 (33%), Positives = 37/71 (52%), Gaps = 3/71 (4%)
Query: 585 LDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLS--AKCHYLHILDISGC 642
L ++Y S +S +++ + C NL L + I+DSA + S C L LD+SGC
Sbjct: 335 LVLAYSSAVSSKMVRQILELCPNLEHLDLTQTD-ISDSAFDSWSWLGCCQSLRHLDLSGC 393
Query: 643 VLLTDQILEDL 653
+TD LE +
Sbjct: 394 EKITDVALEKI 404
Score = 35.8 bits (81), Expect = 0.15
Identities = 35/135 (25%), Positives = 57/135 (42%), Gaps = 13/135 (9%)
Query: 321 NGCHK--LIYLDLSGCTQ--ISVQGFRYIANS--CTGIMHLTINDMPTLTDNCVKALVEK 374
+GC ++ L S C Q + F Y +S CTG T++ +P + C KA +
Sbjct: 518 SGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTR 577
Query: 375 CSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKF--IDKNYPNLSHIY 432
R L++ G+ T R L L G ++TD + + P L H+
Sbjct: 578 LPRGKDLIYFGSEKSDQETGRVLLFLSL-----SGCYQITDHGLRVLTLGGGLPYLEHLN 632
Query: 433 MADCKGITDSSLRSL 447
++ C IT + L+ L
Sbjct: 633 LSGCLTITGAGLQDL 647
Score = 33.5 bits (75), Expect = 0.73
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 6/81 (7%)
Query: 559 LSVSECYRITDDGIQAFCKSSLI--LEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGC 616
LS+S CY+ITD G++ + LEHL++S C ++ ++ L C +L C
Sbjct: 603 LSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYC 662
Query: 617 PKI----TDSAMEMLSAKCHY 633
I D+A + +C +
Sbjct: 663 DNINGPHADTASGCQNLQCGF 683
Score = 32.7 bits (73), Expect = 1.2
Identities = 19/49 (38%), Positives = 30/49 (61%), Gaps = 3/49 (6%)
Query: 582 LEHLDVSYCSQLSDMIIKALAIY--CINLTSLSIAGCPKITDSAMEMLS 628
LEHLD++ + +SD + + C +L L ++GC KITD A+E +S
Sbjct: 358 LEHLDLTQ-TDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKIS 405
Score = 32.3 bits (72), Expect = 1.6
Identities = 21/78 (26%), Positives = 35/78 (44%), Gaps = 2/78 (2%)
Query: 326 LIYLDLSGCTQISVQGFRY--IANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVF 383
L++L LSGC QI+ G R + + HL ++ T+T ++ LV C + F
Sbjct: 600 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 659
Query: 384 TGAPHISDCTFRALSACK 401
+I+ S C+
Sbjct: 660 YYCDNINGPHADTASGCQ 677
>gi|16506299 leucine rich repeat containing 42 [Homo sapiens]
Length = 428
Score = 43.9 bits (102), Expect = 5e-04
Identities = 35/115 (30%), Positives = 56/115 (48%), Gaps = 12/115 (10%)
Query: 439 ITDSSLRSLSPLKQLTVLNLANCVRIGDMG-LKQFLDGPASMRIRELNLS-NCVRLSDAS 496
+ L + ++LT L+L+ C ++GD L + L A + +L+L NC LSDA
Sbjct: 161 VISEKLEEIKSFRELTCLDLS-CCKLGDEHELLEHLTNEALSSVTQLHLKDNC--LSDAG 217
Query: 497 VMKLS-------ERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISN 544
V K++ NL L L +T GIGY+ + L +D+SGT + +
Sbjct: 218 VRKMTAPVRVMKRGLENLTLLDLSCNPEITDAGIGYLFSFRKLNCLDISGTGLKD 272
Score = 30.0 bits (66), Expect = 8.0
Identities = 29/123 (23%), Positives = 55/123 (44%), Gaps = 8/123 (6%)
Query: 236 KTFRSVSHCRNLQELNVSD----CPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLL 291
K+FR ++ C +L + D T+E++ +++ CL+ + +R++
Sbjct: 170 KSFRELT-CLDLSCCKLGDEHELLEHLTNEALSSVTQLHLKDNCLSDAGVRKMTAPVRVM 228
Query: 292 PRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTG 351
R NL L L+ TD G+ YL KL LD+SG ++ ++ + G
Sbjct: 229 KRGLENLTLLDLSCNPEITDAGIGYL---FSFRKLNCLDISGTGLKDIKTVKHKLQTHIG 285
Query: 352 IMH 354
++H
Sbjct: 286 LVH 288
>gi|169160755 PREDICTED: zyg-11 homolog A (C. elegans) [Homo
sapiens]
Length = 736
Score = 43.1 bits (100), Expect = 0.001
Identities = 65/236 (27%), Positives = 109/236 (46%), Gaps = 20/236 (8%)
Query: 402 LRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANC 461
LR + ++G ++TD + N L + + K T + +++ K L LN A
Sbjct: 79 LRVMTWQG--KLTDRTASIFRGNQMKLKLVNIQKAKISTAAFIKAFCRHK-LIELN-ATA 134
Query: 462 VRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSE-----RCPNLNYLSLRN-C 515
V D+ + + G S R + NL C+ L S+ + S + L LS+ N C
Sbjct: 135 VH-ADLPVPDIISGLCSNRWIQQNLQ-CLLLDSTSIPQNSRLLFFSQLTGLRILSVFNVC 192
Query: 516 EHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKELSVS--ECYRITDDGIQ 573
H + + + + L S+D+S T +++ +L+ +LK L++ +C +T I
Sbjct: 193 FH--TEDLANVSQLPRLESLDISNTLVTDISA-LLTCKDRLKSLTMHYLKCLAMTKSQIL 249
Query: 574 AFCKSSLILEHLDVSYCSQL-SDMIIKALAIYCI--NLTSLSIAGCPKITDSAMEM 626
A + L HLD+S QL SD+ L I N+ SL I+G ITD A+E+
Sbjct: 250 AVIRELKCLLHLDISDHRQLKSDLAFHLLQQKDILPNVVSLDISGGNCITDEAVEL 305
>gi|88948888 PREDICTED: zyg-11 homolog A (C. elegans) [Homo sapiens]
Length = 736
Score = 43.1 bits (100), Expect = 0.001
Identities = 65/236 (27%), Positives = 109/236 (46%), Gaps = 20/236 (8%)
Query: 402 LRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANC 461
LR + ++G ++TD + N L + + K T + +++ K L LN A
Sbjct: 79 LRVMTWQG--KLTDRTASIFRGNQMKLKLVNIQKAKISTAAFIKAFCRHK-LIELN-ATA 134
Query: 462 VRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSE-----RCPNLNYLSLRN-C 515
V D+ + + G S R + NL C+ L S+ + S + L LS+ N C
Sbjct: 135 VH-ADLPVPDIISGLCSNRWIQQNLQ-CLLLDSTSIPQNSRLLFFSQLTGLRILSVFNVC 192
Query: 516 EHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKELSVS--ECYRITDDGIQ 573
H + + + + L S+D+S T +++ +L+ +LK L++ +C +T I
Sbjct: 193 FH--TEDLANVSQLPRLESLDISNTLVTDISA-LLTCKDRLKSLTMHYLKCLAMTKSQIL 249
Query: 574 AFCKSSLILEHLDVSYCSQL-SDMIIKALAIYCI--NLTSLSIAGCPKITDSAMEM 626
A + L HLD+S QL SD+ L I N+ SL I+G ITD A+E+
Sbjct: 250 AVIRELKCLLHLDISDHRQLKSDLAFHLLQQKDILPNVVSLDISGGNCITDEAVEL 305
>gi|113408672 PREDICTED: zyg-11 homolog A [Homo sapiens]
Length = 759
Score = 43.1 bits (100), Expect = 0.001
Identities = 65/236 (27%), Positives = 109/236 (46%), Gaps = 20/236 (8%)
Query: 402 LRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANC 461
LR + ++G ++TD + N L + + K T + +++ K L LN A
Sbjct: 79 LRVMTWQG--KLTDRTASIFRGNQMKLKLVNIQKAKISTAAFIKAFCRHK-LIELN-ATA 134
Query: 462 VRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSE-----RCPNLNYLSLRN-C 515
V D+ + + G S R + NL C+ L S+ + S + L LS+ N C
Sbjct: 135 VH-ADLPVPDIISGLCSNRWIQQNLQ-CLLLDSTSIPQNSRLLFFSQLTGLRILSVFNVC 192
Query: 516 EHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKELSVS--ECYRITDDGIQ 573
H + + + + L S+D+S T +++ +L+ +LK L++ +C +T I
Sbjct: 193 FH--TEDLANVSQLPRLESLDISNTLVTDISA-LLTCKDRLKSLTMHYLKCLAMTKSQIL 249
Query: 574 AFCKSSLILEHLDVSYCSQL-SDMIIKALAIYCI--NLTSLSIAGCPKITDSAMEM 626
A + L HLD+S QL SD+ L I N+ SL I+G ITD A+E+
Sbjct: 250 AVIRELKCLLHLDISDHRQLKSDLAFHLLQQKDILPNVVSLDISGGNCITDEAVEL 305
>gi|226437632 zyg-11 homolog A [Homo sapiens]
Length = 759
Score = 43.1 bits (100), Expect = 0.001
Identities = 65/236 (27%), Positives = 109/236 (46%), Gaps = 20/236 (8%)
Query: 402 LRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANC 461
LR + ++G ++TD + N L + + K T + +++ K L LN A
Sbjct: 79 LRVMTWQG--KLTDRTASIFRGNQMKLKLVNIQKAKISTAAFIKAFCRHK-LIELN-ATA 134
Query: 462 VRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSE-----RCPNLNYLSLRN-C 515
V D+ + + G S R + NL C+ L S+ + S + L LS+ N C
Sbjct: 135 VH-ADLPVPDIISGLCSNRWIQQNLQ-CLLLDSTSIPQNSRLLFFSQLTGLRILSVFNVC 192
Query: 516 EHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKELSVS--ECYRITDDGIQ 573
H + + + + L S+D+S T +++ +L+ +LK L++ +C +T I
Sbjct: 193 FH--TEDLANVSQLPRLESLDISNTLVTDISA-LLTCKDRLKSLTMHYLKCLAMTKSQIL 249
Query: 574 AFCKSSLILEHLDVSYCSQL-SDMIIKALAIYCI--NLTSLSIAGCPKITDSAMEM 626
A + L HLD+S QL SD+ L I N+ SL I+G ITD A+E+
Sbjct: 250 AVIRELKCLLHLDISDHRQLKSDLAFHLLQQKDILPNVVSLDISGGNCITDEAVEL 305
>gi|148922963 F-box and leucine-rich repeat protein 21 [Homo
sapiens]
Length = 434
Score = 41.2 bits (95), Expect = 0.003
Identities = 85/380 (22%), Positives = 156/380 (41%), Gaps = 53/380 (13%)
Query: 150 TLKCDISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDF-------SS 202
T+ D LP +LQIF YL L D V W + ++ LW +F SS
Sbjct: 37 TVLLDWGSLPHHVVLQIFQYLPLLDRACASSVCRRWNEVFHISDLWRKFEFELNQSATSS 96
Query: 203 VKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDES 262
K+ PD I +++ ++ ++F+ + + + C L +L +C + ++
Sbjct: 97 FKSTHPD-LIQQIIKKHFAHLQYVSFK---VDSSAESAEAACDILSQL--VNC---SIQT 147
Query: 263 MRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCR--RFTDKGLQYLNLG 320
+ IS P +N+S + + L F N ++LS D L+ L +
Sbjct: 148 LGLISTAKPSF--MNVSESHFVS----ALTVVFINSKSLSSIKIEDTPVDDPSLKIL-VA 200
Query: 321 NGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITS 380
N L +S C +S G +A+ C G+ L +N LTD AL + +
Sbjct: 201 NNSDTLRLPKMSSCPHVSSDGILCVADRCQGLRELALN-YYILTDELFLALSSETH--VN 257
Query: 381 LVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLS---HIYMADCK 437
L +S+ +I+F K+ S+ + K+ P ++ H ++ + +
Sbjct: 258 LEHLRIDVVSE---------NPGQIKFHAVKK---HSWDALIKHSPRVNVVMHFFLYEEE 305
Query: 438 GITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNL-SNCVRLSDAS 496
++ + +P+ L + V +G +GL R+ EL + +N ++ D
Sbjct: 306 --FETFFKEETPVTHLYFGRSVSKVVLGRVGLN-------CPRLIELVVCANDLQPLDNE 356
Query: 497 VMKLSERCPNLNYLSLRNCE 516
++ ++E C NL L L CE
Sbjct: 357 LICIAEHCTNLTALGLSKCE 376
>gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 family,
member E isoform 1 [Homo sapiens]
Length = 268
Score = 39.7 bits (91), Expect = 0.010
Identities = 28/94 (29%), Positives = 49/94 (52%), Gaps = 8/94 (8%)
Query: 451 KQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYL 510
K+L L++AN + L P+ ++R+L LS+ + V L+E+CPNL YL
Sbjct: 42 KELEFLSMAN------VELSSLARLPSLNKLRKLELSDNIISGGLEV--LAEKCPNLTYL 93
Query: 511 SLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISN 544
+L + + + N+ +L S+DL +I+N
Sbjct: 94 NLSGNKIKDLSTVEALQNLKNLKSLDLFNCEITN 127
Score = 30.8 bits (68), Expect = 4.7
Identities = 20/67 (29%), Positives = 34/67 (50%), Gaps = 2/67 (2%)
Query: 395 RALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLT 454
R S KLRK+ N + + + + PNL+++ ++ K S++ +L LK L
Sbjct: 59 RLPSLNKLRKLELSDN--IISGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLK 116
Query: 455 VLNLANC 461
L+L NC
Sbjct: 117 SLDLFNC 123
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,627,875
Number of Sequences: 37866
Number of extensions: 1055142
Number of successful extensions: 3175
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 2471
Number of HSP's gapped (non-prelim): 258
length of query: 735
length of database: 18,247,518
effective HSP length: 110
effective length of query: 625
effective length of database: 14,082,258
effective search space: 8801411250
effective search space used: 8801411250
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.