Search of human proteins with 158138530

Search of human proteins with 158138530

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|158138530 cytochrome P450, family 4, subfamily F,
polypeptide 22 [Homo sapiens]
         (531 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide...  1088   0.0  
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ...   703   0.0  
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide...   696   0.0  
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...   689   0.0  
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...   689   0.0  
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...   679   0.0  
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...   660   0.0  
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide...   410   e-114
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide...   399   e-111
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide...   398   e-111
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ...   389   e-108
gi|30023836 cytochrome P450 4Z1 [Homo sapiens]                        375   e-104
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ...   374   e-104
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   278   1e-74
gi|239757171 PREDICTED: similar to cytochrome P450, family 4, su...   181   1e-45
gi|239751683 PREDICTED: similar to cytochrome P450, family 4, su...   181   1e-45
gi|239746187 PREDICTED: similar to cytochrome P450, family 4, su...   181   1e-45
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   166   6e-41
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   161   2e-39
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   153   3e-37
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   153   3e-37
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   144   2e-34
gi|5729796 cytochrome P450, family 46 [Homo sapiens]                  138   1e-32
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ...   127   3e-29
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H...   114   2e-25
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H...   114   2e-25
gi|225903399 cytochrome P450, family 51, subfamily A, polypeptid...   106   5e-23
gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide ...   106   5e-23
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   103   4e-22
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ...    98   2e-20

>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
           [Homo sapiens]
          Length = 531

 Score = 1088 bits (2815), Expect = 0.0
 Identities = 531/531 (100%), Positives = 531/531 (100%)

Query: 1   MLPITDRLLHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFP 60
           MLPITDRLLHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFP
Sbjct: 1   MLPITDRLLHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFP 60

Query: 61  QPPRRNWLLGHLGMYLPNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLG 120
           QPPRRNWLLGHLGMYLPNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLG
Sbjct: 61  QPPRRNWLLGHLGMYLPNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLG 120

Query: 121 ASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSAD 180
           ASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSAD
Sbjct: 121 ASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSAD 180

Query: 181 IMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALS 240
           IMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALS
Sbjct: 181 IMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALS 240

Query: 241 VRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQG 300
           VRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQG
Sbjct: 241 VRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQG 300

Query: 301 KTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEK 360
           KTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEK
Sbjct: 301 KTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEK 360

Query: 361 CREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRI 420
           CREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRI
Sbjct: 361 CREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRI 420

Query: 421 IPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSF 480
           IPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSF
Sbjct: 421 IPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSF 480

Query: 481 AMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPLPPRA 531
           AMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPLPPRA
Sbjct: 481 AMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPLPPRA 531


>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
           [Homo sapiens]
          Length = 520

 Score =  703 bits (1814), Expect = 0.0
 Identities = 335/506 (66%), Positives = 413/506 (81%), Gaps = 2/506 (0%)

Query: 23  AVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGL 82
           A S  LL LL     LL   L    +FY  CRRLRCFPQPPRRNW  GH GM  P E G+
Sbjct: 15  AASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGM 74

Query: 83  QDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGD 142
           +   +++        VWMGP+ PLL L HPD I+ ++ ASAAIAPKD  FY FL+PWLGD
Sbjct: 75  RVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGD 134

Query: 143 GLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEH 202
           GLLLS GDKWSRHRR+LTPAFHF+ILKPYMKIFN+S +IMHAKW+ LA   +  LDMFEH
Sbjct: 135 GLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEH 194

Query: 203 ISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGR 262
           ISLMTLDSLQKCVFS++S+CQEK S+YI+AI+ELSAL  +R + +  ++DF+YY + DG+
Sbjct: 195 ISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQ 254

Query: 263 RFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAK-QGKTLDFIDVLLLARDEDGKELS 321
           RFR+AC +VH FT  VIQERRR L  QG + +L+AK + KTLDFIDVLLL++DEDGK+LS
Sbjct: 255 RFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLS 314

Query: 322 DEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDD 381
           DEDIRAEADTFMFEGHDTT+SG+SW+L++LAK+PEYQE+CR+E+QE++K RE +E+EWDD
Sbjct: 315 DEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDD 374

Query: 382 LTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVW 441
           L  LPF TMC+KESLR +PPV ++SR  T+DI LPDGR+IPKGIICL+S++GTHHNP VW
Sbjct: 375 LAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW 434

Query: 442 PDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVD 501
           PD +VY+P+RFDP+N ++RSPLA++PFSAGPRNCIGQ+FAMAE++VV+ALTLLRFR+  D
Sbjct: 435 PDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPD 494

Query: 502 RTRKVRRKPELILRTENGLWLKVEPL 527
            T + RRKPEL+LR E GLWL+VEPL
Sbjct: 495 HT-EPRRKPELVLRAEGGLWLRVEPL 519


>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
           [Homo sapiens]
          Length = 520

 Score =  696 bits (1795), Expect = 0.0
 Identities = 334/506 (66%), Positives = 410/506 (81%), Gaps = 2/506 (0%)

Query: 23  AVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGL 82
           A S  LL LL     LL R L    +FY  C RLRCFPQPP+RNW LGHLG+   +E GL
Sbjct: 15  AASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHLGLIHSSEEGL 74

Query: 83  QDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGD 142
              + +      +   W+GP   ++ + HP YIKP+L A AAI PKD +FY FLKPWLGD
Sbjct: 75  LYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGD 134

Query: 143 GLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEH 202
           GLLLS G+KWSRHRR+LTPAFHF+ILKPYMKIFN+S +IMHAKW+ LA   +  LDMFEH
Sbjct: 135 GLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEH 194

Query: 203 ISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGR 262
           ISLMTLDSLQKCVFS++S+CQEK S+YI+AI+ELSAL  +R  ++  Y+DF+YY + DG+
Sbjct: 195 ISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQ 254

Query: 263 RFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAK-QGKTLDFIDVLLLARDEDGKELS 321
           RFR+AC +VH FT  VIQERRR L  QG + +L+AK + KTLDFIDVLLL++DEDGK+LS
Sbjct: 255 RFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLS 314

Query: 322 DEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDD 381
           DEDIRAEADTFMFEGHDTT+SG+SW+L++LAK+PEYQE+CR+E+QE++K RE +E+EWDD
Sbjct: 315 DEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDD 374

Query: 382 LTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVW 441
           L QLPF TMCIKESLR +PPV  VSR CT+DI LPDGR+IPKGIICL+S++GTHHNP VW
Sbjct: 375 LAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW 434

Query: 442 PDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVD 501
           PD +VY+P+RFDP N ++RSPLA++PFSAGPRNCIGQ+FAMAE++VV+ LTLLRFR+  D
Sbjct: 435 PDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPD 494

Query: 502 RTRKVRRKPELILRTENGLWLKVEPL 527
            T + RRKPEL+LR E GLWL+VEPL
Sbjct: 495 HT-EPRRKPELVLRAEGGLWLRVEPL 519


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  689 bits (1777), Expect = 0.0
 Identities = 329/506 (65%), Positives = 406/506 (80%), Gaps = 2/506 (0%)

Query: 23  AVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGL 82
           A S  LL LL     LL R L    +FY  CRRL+CFPQPP++NW  GH G+  P E G+
Sbjct: 15  AASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQGLVTPTEEGM 74

Query: 83  QDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGD 142
           +   +++        +W+GP  PLL+L HPD I+P+  ASAA+APKD +FYGFLKPWLGD
Sbjct: 75  KTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGD 134

Query: 143 GLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEH 202
           GLLLS GDKWSRHRR+LTPAFHF+ILKPYMKIFN+S +IMH KW+ LA   +  LDMFEH
Sbjct: 135 GLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEH 194

Query: 203 ISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGR 262
           ISLMTLDSLQKCVFS+ SNCQEK S+YI+AI+ELSA   +R  ++  + DF+YY + DG+
Sbjct: 195 ISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQ 254

Query: 263 RFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAK-QGKTLDFIDVLLLARDEDGKELS 321
           RFR+AC +VH FT  VIQERR  L  QG + +LK K + KTLDFIDVLLL++DEDGKELS
Sbjct: 255 RFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELS 314

Query: 322 DEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDD 381
           DEDIRAEADTFMFEGHDTT+SG+SW+L++LAK+PEYQE+CR+E+QE++K RE  E+EWDD
Sbjct: 315 DEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDD 374

Query: 382 LTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVW 441
           L QLPF TMCIKESLR +PPV ++SR CT+D  LPDGR+IPKGI+CL++I G H+NPTVW
Sbjct: 375 LAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVW 434

Query: 442 PDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVD 501
           PD +VY+P+RFD +N ++RSPLA++PFSAGPRNCIGQ+FAMAE++VV+ALTLL FR+   
Sbjct: 435 PDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPT 494

Query: 502 RTRKVRRKPELILRTENGLWLKVEPL 527
            T + RRKPELILR E GLWL+VEPL
Sbjct: 495 HT-EPRRKPELILRAEGGLWLRVEPL 519


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  689 bits (1777), Expect = 0.0
 Identities = 329/506 (65%), Positives = 406/506 (80%), Gaps = 2/506 (0%)

Query: 23  AVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGL 82
           A S  LL LL     LL R L    +FY  CRRL+CFPQPP++NW  GH G+  P E G+
Sbjct: 15  AASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQGLVTPTEEGM 74

Query: 83  QDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGD 142
           +   +++        +W+GP  PLL+L HPD I+P+  ASAA+APKD +FYGFLKPWLGD
Sbjct: 75  KTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGD 134

Query: 143 GLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEH 202
           GLLLS GDKWSRHRR+LTPAFHF+ILKPYMKIFN+S +IMH KW+ LA   +  LDMFEH
Sbjct: 135 GLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEH 194

Query: 203 ISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGR 262
           ISLMTLDSLQKCVFS+ SNCQEK S+YI+AI+ELSA   +R  ++  + DF+YY + DG+
Sbjct: 195 ISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQ 254

Query: 263 RFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAK-QGKTLDFIDVLLLARDEDGKELS 321
           RFR+AC +VH FT  VIQERR  L  QG + +LK K + KTLDFIDVLLL++DEDGKELS
Sbjct: 255 RFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELS 314

Query: 322 DEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDD 381
           DEDIRAEADTFMFEGHDTT+SG+SW+L++LAK+PEYQE+CR+E+QE++K RE  E+EWDD
Sbjct: 315 DEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDD 374

Query: 382 LTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVW 441
           L QLPF TMCIKESLR +PPV ++SR CT+D  LPDGR+IPKGI+CL++I G H+NPTVW
Sbjct: 375 LAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVW 434

Query: 442 PDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVD 501
           PD +VY+P+RFD +N ++RSPLA++PFSAGPRNCIGQ+FAMAE++VV+ALTLL FR+   
Sbjct: 435 PDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPT 494

Query: 502 RTRKVRRKPELILRTENGLWLKVEPL 527
            T + RRKPELILR E GLWL+VEPL
Sbjct: 495 HT-EPRRKPELILRAEGGLWLRVEPL 519


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score =  679 bits (1751), Expect = 0.0
 Identities = 325/520 (62%), Positives = 405/520 (77%), Gaps = 2/520 (0%)

Query: 9   LHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWL 68
           + LL L     R  A+S  LL LL     LL R L    +FY  CRRL+CFPQPP+RNW 
Sbjct: 1   MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF 60

Query: 69  LGHLGMYLPNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPK 128
            GHLG+  P E GL+D  ++         VW+GP++P +VL HPD I+ +  ASAAIAPK
Sbjct: 61  WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK 120

Query: 129 DDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRH 188
           D+LF  FLKPWLG+G+LLS GDKWSRHRR+LTPAFHF+ILK Y+ IFN+SA+IM  KW+H
Sbjct: 121 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH 180

Query: 189 LAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLH 248
           LA   +  LDMFEHISLMTLDSLQKC+FS++S+CQE+ S+YI+ I+ELSAL  +R   + 
Sbjct: 181 LASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL 240

Query: 249 HYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAK-QGKTLDFID 307
            ++DF+YY S DGRRF +AC +VH FT  VI+ERRR L  QG + + K K + KTLDFID
Sbjct: 241 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID 300

Query: 308 VLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQE 367
           VLLL++DEDGK LSDEDIRAEADTFMF GHDTT+SG+SW+L+NLA++PEYQE+CR+E+QE
Sbjct: 301 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360

Query: 368 VMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIIC 427
           ++K R+ +E+EWDDL QLPF TMC+KESLR +PP   +SR CT+DI LPDGR+IPKGI C
Sbjct: 361 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC 420

Query: 428 LVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRV 487
           L+ I G HHNPTVWPD +VY+P+RFDP+N + RSPLA++PFSAGPRNCIGQ+FAMAE++V
Sbjct: 421 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV 480

Query: 488 VVALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPL 527
           V+AL LL FR   D T + RRK ELI+R E GLWL+VEPL
Sbjct: 481 VLALMLLHFRFLPDHT-EPRRKLELIMRAEGGLWLRVEPL 519


>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score =  660 bits (1703), Expect = 0.0
 Identities = 314/520 (60%), Positives = 404/520 (77%), Gaps = 2/520 (0%)

Query: 9   LHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWL 68
           + LL L     R  A S  LL L+     LL R L    +FY   RRLRCFPQP ++NW 
Sbjct: 1   MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF 60

Query: 69  LGHLGMYLPNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPK 128
           LGHLG+  P E GL+   +++       + W+GP+ P++ L HPD ++ ++  S AI  K
Sbjct: 61  LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK 120

Query: 129 DDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRH 188
           D +FY  LKPWLGDGLLLS GDKW  HRRLLTPAFHF+ILKPY+KIF++SA+IMHAKW+ 
Sbjct: 121 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR 180

Query: 189 LAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLH 248
           LA   +  LD+FEHISLMTLDSLQKC+FS++SNCQEK S+YI+AI+ELSAL V+R  +  
Sbjct: 181 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF 240

Query: 249 HYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAK-QGKTLDFID 307
            Y DF+Y+ +  GRRF +AC +VH FT  VIQERRR L  QG + +L+AK + KTLDFID
Sbjct: 241 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID 300

Query: 308 VLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQE 367
           VLLL+ D++GKELSDEDIRAEADTFMF GHDTT+SG+SW+L+NLA++PEYQE+CR+E+QE
Sbjct: 301 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360

Query: 368 VMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIIC 427
           ++K RE +E+EWDDL QLPF TMC+KESLR +PP+   +R CT+D+ LPD R+IPKG +C
Sbjct: 361 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC 420

Query: 428 LVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRV 487
            ++I+  HHNP+VWPD +VY+P+RFDP+N Q+RSP+A++PFSAGPRNCIGQ FAMAE++V
Sbjct: 421 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV 480

Query: 488 VVALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPL 527
           V+ALTLLRFR+  D  R+ RR PE++LR E+GLWL+VEPL
Sbjct: 481 VLALTLLRFRILPDH-REPRRTPEIVLRAEDGLWLRVEPL 519


>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
           [Homo sapiens]
          Length = 519

 Score =  410 bits (1053), Expect = e-114
 Identities = 223/499 (44%), Positives = 312/499 (62%), Gaps = 14/499 (2%)

Query: 32  LFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGLQDEKKVLDN 91
           L  L  LL++ ++L        + L+ FP PP  +WL GH+   L  +  LQ  +K ++ 
Sbjct: 24  LLILLLLLIKAVQLYLHRQWLLKALQQFPCPPS-HWLFGHI-QELQQDQELQRIQKWVET 81

Query: 92  MHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDK 151
                  W+      + L  PDY+K +LG S    PK    Y FL PW+G GLLL  G  
Sbjct: 82  FPSACPHWLWGGKVRVQLYDPDYMKVILGRSD---PKSHGSYRFLAPWIGYGLLLLNGQT 138

Query: 152 WSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSL 211
           W +HRR+LTPAFH+DILKPY+ +   S  +M  KW  L  G    L++F+H+SLMTLD++
Sbjct: 139 WFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELL-GQDSPLEVFQHVSLMTLDTI 197

Query: 212 QKCVFSYNSNCQ--EKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACD 269
            KC FS+  + Q       YI AI +L+ L   R     H  D IY  ++ GR   +AC 
Sbjct: 198 MKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQ 257

Query: 270 MVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEA 329
           + H  T +VIQ R+  L+++G    +K K  + LDF+D+LLLA+ E+G  LSD+D+RAE 
Sbjct: 258 LAHQHTDQVIQLRKAQLQKEGELEKIKRK--RHLDFLDILLLAKMENGSILSDKDLRAEV 315

Query: 330 DTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTT 389
           DTFMFEGHDTT+SGISW+L+ LA +P++QE+CREEI  ++   +   + W+ L Q+P+TT
Sbjct: 316 DTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLG--DGASITWNHLDQMPYTT 373

Query: 390 MCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNP 449
           MCIKE+LR YPPV  + R+ +  +  PDGR +PKGI+ L+SIYG HHNP VWP+ +V++P
Sbjct: 374 MCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDP 433

Query: 450 YRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRK 509
           +RF P + Q     A++PFS G RNCIG+ FAM EL+V  ALTLLRF L  D TR     
Sbjct: 434 FRFAPGSAQHSH--AFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPI 491

Query: 510 PELILRTENGLWLKVEPLP 528
             L+L+++NG+ L++  LP
Sbjct: 492 ARLVLKSKNGIHLRLRRLP 510


>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform b [Homo sapiens]
          Length = 511

 Score =  399 bits (1025), Expect = e-111
 Identities = 212/519 (40%), Positives = 308/519 (59%), Gaps = 18/519 (3%)

Query: 12  LGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGH 71
           L L  ++  ++A   +L+     L  LLLR   L ++       +  FP PP  +WL GH
Sbjct: 6   LSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKA-------MDKFPGPPT-HWLFGH 57

Query: 72  LGMYLPNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDL 131
             + +     L           +   +W G  +  L +  PDY K +       AP    
Sbjct: 58  -ALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPD--- 113

Query: 132 FYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAE 191
            Y F   W+G GLL+ +G KW +HR+LLTP FH+D+LKPY+ +F +S  IM  KW   A 
Sbjct: 114 VYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAR 173

Query: 192 GSAVSLDMFEHISLMTLDSLQKCVFSY-NSNCQEKMSDYISAIIELSALSVRRQYRLHHY 250
               S D+F  +  M L++L KC F   ++    + S Y  A+ +L+ L  +R     ++
Sbjct: 174 -EGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYH 232

Query: 251 LDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLL 310
            DFIY+ +  GRRF +AC + H  T +VI+ER+ AL+ +      K +  + LDF+D+LL
Sbjct: 233 NDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRK--KIQNRRHLDFLDILL 290

Query: 311 LARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMK 370
            ARDED  +LSD D+RAE DTFMFEGHDTT+SGISW L+ +A YPE+Q +CREE++E++ 
Sbjct: 291 GARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILG 350

Query: 371 GRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVS 430
            ++    +WDDL ++ + TMCIKES R YPPV  V RQ ++ +   DGR +P G +  + 
Sbjct: 351 DQDF--FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMH 408

Query: 431 IYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVA 490
           IY  H N  VWPD +V++  RF  +N  +R P A++PFSAGPRNCIGQ FAM+E++VV A
Sbjct: 409 IYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTA 468

Query: 491 LTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPLPP 529
           + LLRF  S+D +R   + P+L+LR++NG  L ++PL P
Sbjct: 469 MCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGP 507


>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform a [Homo sapiens]
          Length = 512

 Score =  398 bits (1022), Expect = e-111
 Identities = 212/520 (40%), Positives = 306/520 (58%), Gaps = 19/520 (3%)

Query: 12  LGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGH 71
           L L  ++  ++A   +L+     L  LLLR   L ++       +  FP PP  +WL GH
Sbjct: 6   LSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKA-------MDKFPGPPT-HWLFGH 57

Query: 72  LGMYLPNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDL 131
             + +     L           +   +W G  +  L +  PDY K +       AP    
Sbjct: 58  -ALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPD--- 113

Query: 132 FYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAE 191
            Y F   W+G GLL+ +G KW +HR+LLTP FH+D+LKPY+ +F +S  IM  KW   A 
Sbjct: 114 VYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAR 173

Query: 192 GSAVSLDMFEHISLMTLDSLQKCVFSYNSNC--QEKMSDYISAIIELSALSVRRQYRLHH 249
               S D+F  +  M L++L KC F          + S Y  A+ +L+ L  +R     +
Sbjct: 174 -EGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQY 232

Query: 250 YLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVL 309
           + DFIY+ +  GRRF +AC + H  T +VI+ER+ AL+ +      K +  + LDF+D+L
Sbjct: 233 HNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRK--KIQNRRHLDFLDIL 290

Query: 310 LLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVM 369
           L ARDED  +LSD D+RAE DTFMFEGHDTT+SGISW L+ +A YPE+Q +CREE++E++
Sbjct: 291 LGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREIL 350

Query: 370 KGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLV 429
             ++    +WDDL ++ + TMCIKES R YPPV  V RQ ++ +   DGR +P G +  +
Sbjct: 351 GDQDF--FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISM 408

Query: 430 SIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVV 489
            IY  H N  VWPD +V++  RF  +N  +R P A++PFSAGPRNCIGQ FAM+E++VV 
Sbjct: 409 HIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVT 468

Query: 490 ALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPLPP 529
           A+ LLRF  S+D +R   + P+L+LR++NG  L ++PL P
Sbjct: 469 AMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGP 508


>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
           [Homo sapiens]
          Length = 519

 Score =  389 bits (999), Expect = e-108
 Identities = 221/510 (43%), Positives = 314/510 (61%), Gaps = 19/510 (3%)

Query: 21  IYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEA 80
           I  V++LL+ LL     LL++  +L        + L+ FP PP  +WL GH+  +  ++ 
Sbjct: 18  ILQVTSLLILLL-----LLIKAAQLYLHRQWLLKALQQFPCPPS-HWLFGHIQEF-QHDQ 70

Query: 81  GLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWL 140
            LQ  ++ +         W+      + L  PDY+K +LG S    PK    Y FL P +
Sbjct: 71  ELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSD---PKSHGSYKFLAPRI 127

Query: 141 GDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMF 200
           G GLLL  G  W +HRR+LTPAFH DILKPY+ +   S  +M  KW  L  G    L++F
Sbjct: 128 GYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELL-GQDSPLEVF 186

Query: 201 EHISLMTLDSLQKCVFSYNSNCQ--EKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRS 258
           +H+SLMTLD++ K  FS+  + Q       YI AI +L++L         H  D IY  +
Sbjct: 187 QHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLT 246

Query: 259 ADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGK 318
           + GR   +AC + H  T +VIQ R+  L+++G    +K K  + LDF+D+LLLA+ E+G 
Sbjct: 247 SAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRK--RHLDFLDILLLAKMENGS 304

Query: 319 ELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELE 378
            LSD+D+RAE DTFMFEGHDTT+SGISW+L+ LA +P++QE+CREEI  ++   +   + 
Sbjct: 305 ILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLG--DGASIT 362

Query: 379 WDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNP 438
           W+ L Q+P+TTMCIKE+LR YPPV  + R+ +  +  PDGR +PKGI+ L+SIYG HHNP
Sbjct: 363 WNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNP 422

Query: 439 TVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRL 498
            VWP+ +V++P RF P + Q     A++PFS G RNCIG+ FAM +L+V  ALTLLRF L
Sbjct: 423 KVWPNLEVFDPSRFAPGSAQHSH--AFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFEL 480

Query: 499 SVDRTRKVRRKPELILRTENGLWLKVEPLP 528
             D TR       L+L+++NG+ L++  LP
Sbjct: 481 LPDPTRIPIPMARLVLKSKNGIHLRLRRLP 510


>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
          Length = 505

 Score =  375 bits (964), Expect = e-104
 Identities = 196/496 (39%), Positives = 304/496 (61%), Gaps = 16/496 (3%)

Query: 28  LLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGLQDEKK 87
           LL +L  +  LL + +RL +      R L  FP PP  +W  GH   Y   E   +   K
Sbjct: 15  LLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPA-HWFYGHKEFYPVKE--FEVYHK 71

Query: 88  VLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLS 147
           +++     + +W+GP      +  PDY K LL       PK  + +  L+ W+G GL+  
Sbjct: 72  LMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQD---PKSAVSHKILESWVGRGLVTL 128

Query: 148 KGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWR-HLAEGSAVSLDMFEHISLM 206
            G KW +HR+++ P F+  ILK ++ + ++S  +M  KW  H+A+ S   L++F+H+SLM
Sbjct: 129 DGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSR--LELFQHVSLM 186

Query: 207 TLDSLQKCVFSYNSNCQ--EKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRF 264
           TLDS+ KC FS+  + Q    +  Y+ A+  LS +S +R     H+ D ++  S+ G+ F
Sbjct: 187 TLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIF 246

Query: 265 RQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDED 324
            +    +H FT +VIQ+R+ +L+ +  +      Q +  DF+D+LL A+ E+ K+ S+ D
Sbjct: 247 SKFNQELHQFTEKVIQDRKESLKDKLKQ---DTTQKRRWDFLDILLSAKSENTKDFSEAD 303

Query: 325 IRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQ 384
           ++AE  TFMF GHDTTSS ISW+L+ LAKYPE+Q++CR+EI+E++   +   + W+ L+Q
Sbjct: 304 LQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLG--DGSSITWEHLSQ 361

Query: 385 LPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDS 444
           +P+TTMCIKE LR Y PV  +SR   + I  PDGR +P GI   ++I+  HHNP  W D 
Sbjct: 362 MPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDP 421

Query: 445 KVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTR 504
           +V+NP RF  +N ++  P A++PFSAG RNCIGQ FA+ E +V VALTLLRF+L+ D +R
Sbjct: 422 QVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSR 481

Query: 505 KVRRKPELILRTENGL 520
             +   +++L+++NG+
Sbjct: 482 PPQPVRQVVLKSKNGI 497


>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
           [Homo sapiens]
          Length = 509

 Score =  374 bits (961), Expect = e-104
 Identities = 200/503 (39%), Positives = 295/503 (58%), Gaps = 15/503 (2%)

Query: 30  FLLFFLFRLLLRFLRLCRSFYIT---CRRLRCFPQPPRRNWLLGHLGMYLPNEAGLQDEK 86
           F L F+F L L  L+  + +       R LR FP PP  +W LGH       +  ++  +
Sbjct: 14  FYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPT-HWFLGHQKFI--QDDNMEKLE 70

Query: 87  KVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLL 146
           ++++        W+GP      +  PDY K LL  +    PK      F  P LG GL  
Sbjct: 71  EIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTD---PKSQYLQKFSPPLLGKGLAA 127

Query: 147 SKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLM 206
             G KW +HRRLLTP FHF+ILK Y+++   S  +M  KW  +      S++++EHI+ M
Sbjct: 128 LDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSM 187

Query: 207 TLDSLQKCVFSYNSNCQEKMSD--YISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRF 264
           +LD + KC FS  +NCQ   +   Y  AI ELS +   R Y L ++ D I+  S  G RF
Sbjct: 188 SLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRF 247

Query: 265 RQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDED 324
           ++   +++ +T  +IQER+++L Q G +     K+ K  DF+D++L A+DE G   SD D
Sbjct: 248 QKLSRVLNQYTDTIIQERKKSL-QAGVKQDNTPKR-KYQDFLDIVLSAKDESGSSFSDID 305

Query: 325 IRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQ 384
           + +E  TF+  GHDT ++ ISW+L+ LA  PE+QE+CREE++ ++   +   + WD L +
Sbjct: 306 VHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILG--DGSSITWDQLGE 363

Query: 385 LPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDS 444
           + +TTMCIKE+ R  P V  +SR  ++ +  PDG  +P GI  ++SI+G HHNP VW + 
Sbjct: 364 MSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNP 423

Query: 445 KVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTR 504
           KV++P RF  +N  QR P AY+PFSAG RNCIGQ FAM EL+V +AL LL FR++ D TR
Sbjct: 424 KVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTR 483

Query: 505 KVRRKPELILRTENGLWLKVEPL 527
            +      IL+ +NG++L ++ L
Sbjct: 484 PLTFPNHFILKPKNGMYLHLKKL 506


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  278 bits (710), Expect = 1e-74
 Identities = 171/498 (34%), Positives = 274/498 (55%), Gaps = 18/498 (3%)

Query: 38  LLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPN-EAGLQDEKKVLDNMHHV- 95
           L+L  L+   S+    +++R  P   R   L+GH  +  P+     Q   +  +   H+ 
Sbjct: 29  LVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMP 88

Query: 96  -LLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSR 154
            L +W+GPV P++ L + + ++ +L +S  I       Y FL+PWLG GLL S G+KW  
Sbjct: 89  LLKLWVGPV-PMVALYNAENVEVILTSSKQIDKSS--MYKFLEPWLGLGLLTSTGNKWRS 145

Query: 155 HRRLLTPAFHFDILKPYMKIFNQSADIMHAKW-RHLAEGSAVSLDMFEHISLMTLDSLQK 213
            R++LTP FHF IL+ ++ I N+ A+I+  K  +H+ + +    + F +I+L  LD + +
Sbjct: 146 RRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEA---FNCFFYITLCALDIICE 202

Query: 214 CVFSYNSNCQEKM-SDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVH 272
                N   Q    S+Y+ A+  +S +  RR      +LD  Y    +G   +++  ++H
Sbjct: 203 TAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQILH 262

Query: 273 HFTTEVIQERRRALRQ----QGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAE 328
            FT  VI ER   +      +G        + K   F+D+LL   D++G  LS EDIR E
Sbjct: 263 TFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREE 322

Query: 329 ADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFT 388
            DTFMFEGHDTT++ I+W L+ L   PE Q+K   E+ +V  G+       +DL +L + 
Sbjct: 323 VDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVF-GKSDRPATVEDLKKLRYL 381

Query: 389 TMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYN 448
              IKE+LR +P V L +R  +ED ++   R++ KG   ++  Y  H +P  +P+ + + 
Sbjct: 382 ECVIKETLRLFPSVPLFARSVSEDCEVAGYRVL-KGTEAVIIPYALHRDPRYFPNPEEFQ 440

Query: 449 PYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTR-KVR 507
           P RF P+N Q R P AYVPFSAGPRNCIGQ FA+ E + +++  L  F +  ++ R ++ 
Sbjct: 441 PERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELG 500

Query: 508 RKPELILRTENGLWLKVE 525
            + +LILR  NG+W+K++
Sbjct: 501 LEGQLILRPSNGIWIKLK 518


>gi|239757171 PREDICTED: similar to cytochrome P450, family 4,
           subfamily F, polypeptide 2 [Homo sapiens]
          Length = 190

 Score =  181 bits (460), Expect = 1e-45
 Identities = 87/157 (55%), Positives = 119/157 (75%), Gaps = 1/157 (0%)

Query: 158 LLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFS 217
           +L PAFHF+ILKPYMKIF++S +IMHAKW  L       LDMFEH++LMTLDSLQKCVFS
Sbjct: 1   MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60

Query: 218 YNSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTE 277
           ++S CQEK S+YI++++ELS+L  +R  ++  ++DF+YY + DGR F +AC + H F   
Sbjct: 61  FDSQCQEKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFADA 120

Query: 278 VIQERRRALRQQGAEAWLKAK-QGKTLDFIDVLLLAR 313
            IQE+R  L  QG + +L+AK + KTLDFIDVLL+++
Sbjct: 121 AIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLLISK 157


>gi|239751683 PREDICTED: similar to cytochrome P450, family 4,
           subfamily F, polypeptide 2 [Homo sapiens]
          Length = 190

 Score =  181 bits (460), Expect = 1e-45
 Identities = 87/157 (55%), Positives = 119/157 (75%), Gaps = 1/157 (0%)

Query: 158 LLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFS 217
           +L PAFHF+ILKPYMKIF++S +IMHAKW  L       LDMFEH++LMTLDSLQKCVFS
Sbjct: 1   MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60

Query: 218 YNSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTE 277
           ++S CQEK S+YI++++ELS+L  +R  ++  ++DF+YY + DGR F +AC + H F   
Sbjct: 61  FDSQCQEKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFADA 120

Query: 278 VIQERRRALRQQGAEAWLKAK-QGKTLDFIDVLLLAR 313
            IQE+R  L  QG + +L+AK + KTLDFIDVLL+++
Sbjct: 121 AIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLLISK 157


>gi|239746187 PREDICTED: similar to cytochrome P450, family 4,
           subfamily F, polypeptide 2 [Homo sapiens]
          Length = 190

 Score =  181 bits (460), Expect = 1e-45
 Identities = 87/157 (55%), Positives = 119/157 (75%), Gaps = 1/157 (0%)

Query: 158 LLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFS 217
           +L PAFHF+ILKPYMKIF++S +IMHAKW  L       LDMFEH++LMTLDSLQKCVFS
Sbjct: 1   MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60

Query: 218 YNSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTE 277
           ++S CQEK S+YI++++ELS+L  +R  ++  ++DF+YY + DGR F +AC + H F   
Sbjct: 61  FDSQCQEKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFADA 120

Query: 278 VIQERRRALRQQGAEAWLKAK-QGKTLDFIDVLLLAR 313
            IQE+R  L  QG + +L+AK + KTLDFIDVLL+++
Sbjct: 121 AIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLLISK 157


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  166 bits (419), Expect = 6e-41
 Identities = 122/431 (28%), Positives = 214/431 (49%), Gaps = 28/431 (6%)

Query: 105 PLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFH 164
           P+LV++ PD IK +L         + +  G +  +L   L  ++ ++W R R LL+PAF 
Sbjct: 80  PMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMG-FLKSALSFAEDEEWKRIRTLLSPAFT 138

Query: 165 FDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYN----S 220
               K  + I +Q  D++    R  AE S  S+++ +     T+D +   +F  N    +
Sbjct: 139 SVKFKEMVPIISQCGDMLVRSLRQEAENSK-SINLKDFFGAYTMDVITGTLFGVNLDSLN 197

Query: 221 NCQEKMSDYISAIIELSALS-VRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVI 279
           N Q+     +  +++L  L        L  +L  ++     G   +     V HF    I
Sbjct: 198 NPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD----VTHFLKNSI 253

Query: 280 QERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARD----EDGKELSDEDIRAEADTFMFE 335
           +  +        E+ LK KQ   +DF   ++ +++    +  K LSD ++ A++   +F 
Sbjct: 254 ERMK--------ESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFA 305

Query: 336 GHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKES 395
            +DTTS+ + ++++ LA +P+ Q+K +EEI  V+  +    + +D L Q+ +  M + E+
Sbjct: 306 AYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKA--PVTYDALVQMEYLDMVVNET 363

Query: 396 LRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPD 455
           LR +P V+ V+R C +DI++ +G  IPKG+  +V IY  HH+P  W + + + P RF   
Sbjct: 364 LRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKK 422

Query: 456 NPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPE--LI 513
           N        Y+PF AGPRNCIG  FA+  +++ V   L  F     +  ++  K +   I
Sbjct: 423 NKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPI 482

Query: 514 LRTENGLWLKV 524
           L+ E  + LKV
Sbjct: 483 LQPEKPIVLKV 493


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  161 bits (407), Expect = 2e-39
 Identities = 122/432 (28%), Positives = 214/432 (49%), Gaps = 29/432 (6%)

Query: 105 PLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFH 164
           P+LV++ PD IK +L         + +  G +  +L   L  ++ ++W R R LL+PAF 
Sbjct: 80  PMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMG-FLKSALSFAEDEEWKRIRTLLSPAFT 138

Query: 165 FDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYN----S 220
               K  + I +Q  D++    R  AE S  S+++ +     T+D +   +F  N    +
Sbjct: 139 SVKFKEMVPIISQCGDMLVRSLRQEAENSK-SINLKDFFGAYTMDVITGTLFGVNLDSLN 197

Query: 221 NCQEKMSDYISAIIELSALS-VRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVI 279
           N Q+     +  +++L  L        L  +L  ++     G   +     V HF    I
Sbjct: 198 NPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD----VTHFLKNSI 253

Query: 280 QERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARD----EDGKELSDEDIRAEADTFMFE 335
           +  +        E+ LK KQ   +DF   ++ +++    +  K LSD ++ A++   +F 
Sbjct: 254 ERMK--------ESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFA 305

Query: 336 GHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKES 395
            +DTTS+ + ++++ LA +P+ Q+K +EEI  V+  +    + +D L Q+ +  M + E+
Sbjct: 306 AYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNK--APVTYDALVQMEYLDMVVNET 363

Query: 396 LRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNP-YRFDP 454
           LR +P V+ V+R C +DI++ +G  IPKG+  +V IY  HH+P  W + + + P  RF  
Sbjct: 364 LRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSK 422

Query: 455 DNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPE--L 512
            N        Y+PF AGPRNCIG  FA+  +++ V   L  F     +  ++  K +   
Sbjct: 423 KNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 482

Query: 513 ILRTENGLWLKV 524
           IL+ E  + LKV
Sbjct: 483 ILQPEKPIVLKV 494


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  153 bits (387), Expect = 3e-37
 Identities = 118/433 (27%), Positives = 212/433 (48%), Gaps = 30/433 (6%)

Query: 105 PLLVLVHPDYIKPLLGASA-AIAPKDDLF--YGFLKPWLGDGLLLSKGDKWSRHRRLLTP 161
           P+L +  PD IK +L     ++      F   GF+K      + +++ ++W R R LL+P
Sbjct: 80  PVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK----SAISIAEDEEWKRLRSLLSP 135

Query: 162 AFHFDILKPYMKIFNQSADIMHAKWRHLAE-GSAVSL-DMFEHISLMTLDSLQKCVFSYN 219
            F    LK  + I  Q  D++    R  AE G  V+L D+F   S+   D +    F  N
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSM---DVITSTSFGVN 192

Query: 220 SNCQEKMSDYISAIIELSALSVRRQYRLHHYLDF-IYYRSADGRRFRQACDMVHHFTTEV 278
            +      D     +E +   +R  +    +L   ++            C     F  EV
Sbjct: 193 IDSLNNPQD---PFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV----FPREV 245

Query: 279 IQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARD----EDGKELSDEDIRAEADTFMF 334
               R+++++   E+ L+  Q   +DF+ +++ +++    E  K LSD ++ A++  F+F
Sbjct: 246 TNFLRKSVKRM-KESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIF 304

Query: 335 EGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKE 394
            G++TTSS +S++++ LA +P+ Q+K +EEI  V+  +      +D + Q+ +  M + E
Sbjct: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT--YDTVLQMEYLDMVVNE 362

Query: 395 SLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDP 454
           +LR +P    + R C +D+++ +G  IPKG++ ++  Y  H +P  W + + + P RF  
Sbjct: 363 TLRLFPIAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421

Query: 455 DNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPEL-- 512
            N     P  Y PF +GPRNCIG  FA+  +++ +   L  F     +  ++  K  L  
Sbjct: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGG 481

Query: 513 ILRTENGLWLKVE 525
           +L+ E  + LKVE
Sbjct: 482 LLQPEKPVVLKVE 494


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  153 bits (387), Expect = 3e-37
 Identities = 120/435 (27%), Positives = 216/435 (49%), Gaps = 34/435 (7%)

Query: 105 PLLVLVHPDYIKPLLGASA-AIAPKDDLF--YGFLKPWLGDGLLLSKGDKWSRHRRLLTP 161
           P+L +  PD IK +L     ++      F   GF+K    + + +++ ++W R R LL+P
Sbjct: 80  PMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK----NAISIAEDEEWKRIRSLLSP 135

Query: 162 AFHFDILKPYMKIFNQSADIMHAKWRHLAE-GSAVSLD-MFEHISL--MTLDSLQKCVFS 217
            F    LK  + I  Q  D++    R  AE G  V+L  +F   S+  +T  S    + S
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDS 195

Query: 218 YNSNCQEKMSDYISAIIELSALS-VRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTT 276
            N N Q+   +    ++  + L       ++  +L  I           +A ++   F  
Sbjct: 196 LN-NPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPIL----------EALNITV-FPR 243

Query: 277 EVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARD----EDGKELSDEDIRAEADTF 332
           +VI    ++++Q   E  LK  Q   +DF+ +++ +++    E  K LSD ++ A++  F
Sbjct: 244 KVISFLTKSVKQI-KEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIF 302

Query: 333 MFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCI 392
           +F G++TTSS +S++++ LA +P+ Q+K ++EI  V+  +      +D + QL +  M +
Sbjct: 303 IFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPT--YDTVLQLEYLDMVV 360

Query: 393 KESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRF 452
            E+LR +P    + R C +D+++ +G  IPKG++ ++  Y  HH+P  W + + + P RF
Sbjct: 361 NETLRLFPVAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERF 419

Query: 453 DPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPEL 512
              N     P  Y PF +GPRNCIG  FA+  +++ +   L  F     +  ++  K   
Sbjct: 420 SKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRF 479

Query: 513 --ILRTENGLWLKVE 525
             +L TE  + LK E
Sbjct: 480 GGLLLTEKPIVLKAE 494


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  144 bits (364), Expect = 2e-34
 Identities = 117/438 (26%), Positives = 210/438 (47%), Gaps = 39/438 (8%)

Query: 104 LPLLVLVHPDYIKPLLGASA--------AIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRH 155
           LP+L +  PD I+ +L            ++ P      GF+K      + L++ ++W R 
Sbjct: 79  LPVLAITDPDVIRTVLVKECYSVFTNRRSLGP-----VGFMK----SAISLAEDEEWKRI 129

Query: 156 RRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAE-GSAVSL-DMFEHISLMTLDSLQK 213
           R LL+P F    LK    I  Q  D++    R  AE G  V+L D+F   S+   D +  
Sbjct: 130 RSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSM---DVITG 186

Query: 214 CVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHH 273
             F  N +      D     +E +   ++  +    +L  I +         +A + V  
Sbjct: 187 TSFGVNIDSLNNPQD---PFVESTKKFLKFGFLDPLFLSIILFPFLTP--VFEALN-VSL 240

Query: 274 FTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARD----EDGKELSDEDIRAEA 329
           F  + I    +++ +   ++ L  KQ   LDF+ +++ +++    E  K LSD ++ A++
Sbjct: 241 FPKDTINFLSKSVNRM-KKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQS 299

Query: 330 DTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTT 389
             F+F G++TTSS +S+ L+ LA +P+ Q+K ++EI  V+  +      +D + Q+ +  
Sbjct: 300 IIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNK--APPTYDAVVQMEYLD 357

Query: 390 MCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNP 449
           M + E+LR +P    + R C +D+++ +G  IPKG + ++  Y  HH+P  W + + + P
Sbjct: 358 MVVNETLRLFPVAIRLERTCKKDVEI-NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRP 416

Query: 450 YRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRK 509
            RF         P  Y PF  GPRNCIG  FA+  +++ +   L  F     +  ++  K
Sbjct: 417 ERFS-KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLK 475

Query: 510 PEL--ILRTENGLWLKVE 525
            +   +L+ E  + LKV+
Sbjct: 476 LDTQGLLQPEKPIVLKVD 493


>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
          Length = 500

 Score =  138 bits (348), Expect = 1e-32
 Identities = 132/490 (26%), Positives = 226/490 (46%), Gaps = 54/490 (11%)

Query: 31  LLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGLQDEKKVLD 90
           LL     +LL F   C   +    R    P PPR ++LLGHL  +   +   +   +VL 
Sbjct: 5   LLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKD---EVGGRVLQ 61

Query: 91  NMHHVLLVWM---GPVLPL-------LVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWL 140
           +   V L W    GPV+ +       +++  P+ +K  L ++     KD   Y  L+   
Sbjct: 62  D---VFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKY--NKDSKMYRALQTVF 116

Query: 141 GDGL----LLSKG--DKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSA 194
           G+ L    L+S+   ++W + RR++  AF    L   M+ FN+ A+ +       A+G  
Sbjct: 117 GERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQT 176

Query: 195 VSLDMFEHISLMTLDSLQKCVFSYNSN----CQEKMSDYISAIIELSALSVRRQYRLHHY 250
             + M + ++   +D L K  F   ++     Q+ +S  +  ++E   ++  R    +  
Sbjct: 177 -PVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLE--GITASR----NTL 229

Query: 251 LDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLL 310
             F+  +    R  R++   +     + +Q RR AL           K+G+ +    +  
Sbjct: 230 AKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREAL-----------KRGEEVPADILTQ 278

Query: 311 LARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMK 370
           + + E+G +  DE +     TF   GH+T+++ +++ +  L++ PE   + + E+ EV+ 
Sbjct: 279 ILKAEEGAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG 337

Query: 371 GRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVS 430
            +    L+++DL +L + +  +KESLR YPP     R   E+  L DG  +P     L S
Sbjct: 338 SKRY--LDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEET-LIDGVRVPGNTPLLFS 394

Query: 431 IYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVA 490
            Y      T + D   +NP RF P  P+ R    Y PFS G R+CIGQ FA  E++VV+A
Sbjct: 395 TYVMGRMDTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMA 452

Query: 491 --LTLLRFRL 498
             L  L FRL
Sbjct: 453 KLLQRLEFRL 462


>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 3 [Homo sapiens]
          Length = 420

 Score =  127 bits (318), Expect = 3e-29
 Identities = 97/356 (27%), Positives = 178/356 (50%), Gaps = 26/356 (7%)

Query: 105 PLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFH 164
           P+LV++ PD IK +L         + +  G +  +L   L  ++ ++W R R LL+PAF 
Sbjct: 80  PMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMG-FLKSALSFAEDEEWKRIRTLLSPAFT 138

Query: 165 FDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYN----S 220
               K  + I +Q  D++    R  AE S  S+++ +     T+D +   +F  N    +
Sbjct: 139 SVKFKEMVPIISQCGDMLVRSLRQEAENSK-SINLKDFFGAYTMDVITGTLFGVNLDSLN 197

Query: 221 NCQEKMSDYISAIIELSALS-VRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVI 279
           N Q+     +  +++L  L        L  +L  ++     G   +     V HF    I
Sbjct: 198 NPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD----VTHFLKNSI 253

Query: 280 QERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARD----EDGKELSDEDIRAEADTFMFE 335
           +  +        E+ LK KQ   +DF   ++ +++    +  K LSD ++ A++   +F 
Sbjct: 254 ERMK--------ESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFA 305

Query: 336 GHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKES 395
            +DTTS+ + ++++ LA +P+ Q+K +EEI  V+  +    + +D L Q+ +  M + E+
Sbjct: 306 AYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNK--APVTYDALVQMEYLDMVVNET 363

Query: 396 LRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYR 451
           LR +P V+ V+R C +DI++ +G  IPKG+  +V IY  HH+P  W + + + P R
Sbjct: 364 LRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418


>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  114 bits (285), Expect = 2e-25
 Identities = 109/448 (24%), Positives = 201/448 (44%), Gaps = 35/448 (7%)

Query: 107 LVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFD 166
           +V+  PD IK +L  + +    + +  G     + D +L  +  +W   R  L  AF  +
Sbjct: 89  IVISEPDMIKQVLVENFSNFT-NRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPE 147

Query: 167 ILKPYMKIFNQSADIMHAKWRHLAE-GSAVSL---------DMFEHISLMT-LDSLQKCV 215
            L   + + +Q+ D++ A  +  AE G A  +         D+   ++  T +DS Q   
Sbjct: 148 KLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPE 207

Query: 216 FSYNSNCQEKMSDYISAIIELSALSVRR-QYRLHHYLDFIYYRSADGRRFRQACDMVHHF 274
             +  +C+      I   I +  LS       L   L        +G   +   +++   
Sbjct: 208 DPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALR 267

Query: 275 TTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDG---------------KE 319
             +  +ERRR   Q   +A   A      DF D++       G               + 
Sbjct: 268 DQQAAEERRRDFLQMVLDARHSASPMGVQDF-DIVRDVFSSTGCKPNPSRQHQPSPMARP 326

Query: 320 LSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEW 379
           L+ ++I  +A  F+  G++  ++ +S+  + LA  P+ QEK   E+ +V K + +   E+
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAP-EF 384

Query: 380 DDLTQ-LPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNP 438
             L + LP+  M I E+LR YPP    +R+  +D ++  G+ IP G +  +++   HH+P
Sbjct: 385 CSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEMAVGALHHDP 443

Query: 439 TVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRL 498
             WP  + +NP RF  +  QQ  P  Y+PF AGPR+C+G    + E+++ +   L +FR 
Sbjct: 444 EHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRF 503

Query: 499 SVDRTRKV--RRKPELILRTENGLWLKV 524
                 +V  + + +  L  +NG+++K+
Sbjct: 504 QACPETQVPLQLESKSALGPKNGVYIKI 531


>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  114 bits (285), Expect = 2e-25
 Identities = 109/448 (24%), Positives = 201/448 (44%), Gaps = 35/448 (7%)

Query: 107 LVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFD 166
           +V+  PD IK +L  + +    + +  G     + D +L  +  +W   R  L  AF  +
Sbjct: 89  IVISEPDMIKQVLVENFSNFT-NRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPE 147

Query: 167 ILKPYMKIFNQSADIMHAKWRHLAE-GSAVSL---------DMFEHISLMT-LDSLQKCV 215
            L   + + +Q+ D++ A  +  AE G A  +         D+   ++  T +DS Q   
Sbjct: 148 KLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPE 207

Query: 216 FSYNSNCQEKMSDYISAIIELSALSVRR-QYRLHHYLDFIYYRSADGRRFRQACDMVHHF 274
             +  +C+      I   I +  LS       L   L        +G   +   +++   
Sbjct: 208 DPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALR 267

Query: 275 TTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDG---------------KE 319
             +  +ERRR   Q   +A   A      DF D++       G               + 
Sbjct: 268 DQQAAEERRRDFLQMVLDARHSASPMGVQDF-DIVRDVFSSTGCKPNPSRQHQPSPMARP 326

Query: 320 LSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEW 379
           L+ ++I  +A  F+  G++  ++ +S+  + LA  P+ QEK   E+ +V K + +   E+
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAP-EF 384

Query: 380 DDLTQ-LPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNP 438
             L + LP+  M I E+LR YPP    +R+  +D ++  G+ IP G +  +++   HH+P
Sbjct: 385 CSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEMAVGALHHDP 443

Query: 439 TVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRL 498
             WP  + +NP RF  +  QQ  P  Y+PF AGPR+C+G    + E+++ +   L +FR 
Sbjct: 444 EHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRF 503

Query: 499 SVDRTRKV--RRKPELILRTENGLWLKV 524
                 +V  + + +  L  +NG+++K+
Sbjct: 504 QACPETQVPLQLESKSALGPKNGVYIKI 531


>gi|225903399 cytochrome P450, family 51, subfamily A, polypeptide 1
           isoform 2 [Homo sapiens]
          Length = 404

 Score =  106 bits (265), Expect = 5e-23
 Identities = 94/370 (25%), Positives = 161/370 (43%), Gaps = 32/370 (8%)

Query: 129 DDLFYGFLKPWLGDGLLLSKGDK-WSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWR 187
           +D++     P  G G+     +  +   +++L    +    K ++ I  +        W 
Sbjct: 29  EDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESW- 87

Query: 188 HLAEGSAVSLDMFEHISLMTLDSLQKCVFS--YNSNCQEKMSDYISAIIELSALSVRRQY 245
               G +   ++FE +S + + +   C+      S   EK++   +   +L        +
Sbjct: 88  ----GESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYA---DLDGGFSHAAW 140

Query: 246 RLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDF 305
            L  +L    +R  D R  R+  D+ +    + IQ+RR++             Q K  D 
Sbjct: 141 LLPGWLPLPSFRRRD-RAHREIKDIFY----KAIQKRRQS-------------QEKIDDI 182

Query: 306 IDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEI 365
           +  LL A  +DG+ L+D+++       +  G  T+S+  +WM F LA+    Q+KC  E 
Sbjct: 183 LQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLE- 241

Query: 366 QEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGI 425
           Q+ + G  L  L +D L  L     CIKE+LR  PP+ ++ R       +  G  IP G 
Sbjct: 242 QKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA-GYTIPPGH 300

Query: 426 ICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAEL 485
              VS          W +   +NP R+  DNP      AYVPF AG   CIG++FA  ++
Sbjct: 301 QVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQI 360

Query: 486 RVVVALTLLR 495
           + + + T+LR
Sbjct: 361 KTIWS-TMLR 369


>gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide 1
           isoform 1 [Homo sapiens]
          Length = 509

 Score =  106 bits (265), Expect = 5e-23
 Identities = 94/370 (25%), Positives = 161/370 (43%), Gaps = 32/370 (8%)

Query: 129 DDLFYGFLKPWLGDGLLLSKGDK-WSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWR 187
           +D++     P  G G+     +  +   +++L    +    K ++ I  +        W 
Sbjct: 134 EDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESW- 192

Query: 188 HLAEGSAVSLDMFEHISLMTLDSLQKCVFS--YNSNCQEKMSDYISAIIELSALSVRRQY 245
               G +   ++FE +S + + +   C+      S   EK++   +   +L        +
Sbjct: 193 ----GESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYA---DLDGGFSHAAW 245

Query: 246 RLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDF 305
            L  +L    +R  D R  R+  D+ +    + IQ+RR++             Q K  D 
Sbjct: 246 LLPGWLPLPSFRRRD-RAHREIKDIFY----KAIQKRRQS-------------QEKIDDI 287

Query: 306 IDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEI 365
           +  LL A  +DG+ L+D+++       +  G  T+S+  +WM F LA+    Q+KC  E 
Sbjct: 288 LQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLE- 346

Query: 366 QEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGI 425
           Q+ + G  L  L +D L  L     CIKE+LR  PP+ ++ R       +  G  IP G 
Sbjct: 347 QKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA-GYTIPPGH 405

Query: 426 ICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAEL 485
              VS          W +   +NP R+  DNP      AYVPF AG   CIG++FA  ++
Sbjct: 406 QVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQI 465

Query: 486 RVVVALTLLR 495
           + + + T+LR
Sbjct: 466 KTIWS-TMLR 474


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  103 bits (257), Expect = 4e-22
 Identities = 85/318 (26%), Positives = 141/318 (44%), Gaps = 29/318 (9%)

Query: 216 FSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRS-ADGRRFRQACDMVHHF 274
           F Y ++  +KM  ++S  +E+   S   Q  L +   ++YY      +  RQ    +  F
Sbjct: 241 FDYTNSEFKKMLGFMSRGLEICLNS---QVLLVNICPWLYYLPFGPFKELRQIEKDITSF 297

Query: 275 TTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAE------ 328
             ++I++ + +L ++  +           DFID+ LL  +E+ K  S+     E      
Sbjct: 298 LKKIIKDHQESLDRENPQ-----------DFIDMYLLHMEEERKNNSNSSFDEEYLFYII 346

Query: 329 ADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFT 388
            D F+  G DTT++ + W L  ++  P+ QEK  EEI+ V+       L   D  Q+P+T
Sbjct: 347 GDLFI-AGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLT--DKAQMPYT 403

Query: 389 TMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYN 448
              I E  R    V L     T +  +  G  IPKG + L +++  H +P +W   + + 
Sbjct: 404 EATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFY 463

Query: 449 PYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRR 508
           P RF  D  Q      ++PF  G R C+G+  A  EL ++    +  F  ++    K   
Sbjct: 464 PNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSK--- 520

Query: 509 KPELILRTENGLWLKVEP 526
           KP  +L    GL L   P
Sbjct: 521 KP--LLTGRFGLTLAPHP 536


>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 508

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 101/399 (25%), Positives = 164/399 (41%), Gaps = 37/399 (9%)

Query: 143 GLLLSKGDKWSRHRRLLTPAFHFDILKPYM------KIFNQSADIMHAKWRHLAEGS--- 193
           GLL ++G++W R R LL P     +L+P         + N   D++    R    G+   
Sbjct: 125 GLLTAEGEEWQRLRSLLAPL----LLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPP 180

Query: 194 AVSLDM--------FEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQY 245
           A+  D+         E I+ + L S   C+ +      E     + ++   + L++   +
Sbjct: 181 ALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPH 240

Query: 246 RLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDF 305
            L H +   +     GR  R    M       V +    A  + G +     + G  L  
Sbjct: 241 WLRHLVPGPW-----GRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTH 295

Query: 306 IDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEI 365
                L R+    EL  + I       +  G DT S+ +SW L+ L+++PE Q     EI
Sbjct: 296 ----FLFRE----ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEI 347

Query: 366 QEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGI 425
              +            L+QLP     +KE LR YP V   SR   +DI + D  IIPK  
Sbjct: 348 TAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGD-YIIPKNT 406

Query: 426 ICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAEL 485
           +  +  Y T  +P  +P+   + P R+  + P    P A +PF  G R+C+G+  A  EL
Sbjct: 407 LVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPH-PFASLPFGFGKRSCMGRRLAELEL 465

Query: 486 RVVVALTLLRFRLSVD-RTRKVRRKPELILRTENGLWLK 523
           ++ +A  L  F +  +     VR K   +L  E  + L+
Sbjct: 466 QMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQ 504


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.141    0.443 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,073,278
Number of Sequences: 37866
Number of extensions: 942560
Number of successful extensions: 2961
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 75
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 2703
Number of HSP's gapped (non-prelim): 112
length of query: 531
length of database: 18,247,518
effective HSP length: 107
effective length of query: 424
effective length of database: 14,195,856
effective search space: 6019042944
effective search space used: 6019042944
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.