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Search of human proteins with 157738667
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
(1478 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 2882 0.0
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 192 2e-48
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 163 1e-39
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 163 1e-39
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 163 1e-39
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 163 1e-39
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 163 1e-39
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 162 2e-39
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 162 2e-39
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 162 2e-39
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 162 2e-39
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 162 2e-39
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 162 2e-39
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 162 2e-39
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 162 2e-39
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 162 2e-39
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 161 4e-39
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 160 8e-39
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 156 1e-37
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 156 1e-37
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 156 1e-37
gi|21735548 centrosomal protein 2 [Homo sapiens] 154 6e-37
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 153 1e-36
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 152 2e-36
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 152 2e-36
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 150 1e-35
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 149 1e-35
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 147 1e-34
gi|55770834 centromere protein F [Homo sapiens] 145 3e-34
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 144 5e-34
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapiens]
Length = 1478
Score = 2882 bits (7472), Expect = 0.0
Identities = 1478/1478 (100%), Positives = 1478/1478 (100%)
Query: 1 MASTNAESQLQRIIRDLQDAVTELSKEFQEAGEPITDDSTSLHKFSYKLEYLLQFDQKEK 60
MASTNAESQLQRIIRDLQDAVTELSKEFQEAGEPITDDSTSLHKFSYKLEYLLQFDQKEK
Sbjct: 1 MASTNAESQLQRIIRDLQDAVTELSKEFQEAGEPITDDSTSLHKFSYKLEYLLQFDQKEK 60
Query: 61 ATLLGNKKDYWDYFCACLAKVKGANDGIRFVKSISELRTSLGKGRAFIRYSLVHQRLADT 120
ATLLGNKKDYWDYFCACLAKVKGANDGIRFVKSISELRTSLGKGRAFIRYSLVHQRLADT
Sbjct: 61 ATLLGNKKDYWDYFCACLAKVKGANDGIRFVKSISELRTSLGKGRAFIRYSLVHQRLADT 120
Query: 121 LQQCFMNTKVTSDWYYARSPFLQPKLSSDIVGQLYELTEVQFDLASRGFDLDAAWPTFAR 180
LQQCFMNTKVTSDWYYARSPFLQPKLSSDIVGQLYELTEVQFDLASRGFDLDAAWPTFAR
Sbjct: 121 LQQCFMNTKVTSDWYYARSPFLQPKLSSDIVGQLYELTEVQFDLASRGFDLDAAWPTFAR 180
Query: 181 RTLTTGSSAYLWKPPSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELD 240
RTLTTGSSAYLWKPPSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELD
Sbjct: 181 RTLTTGSSAYLWKPPSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELD 240
Query: 241 QLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQK 300
QLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQK
Sbjct: 241 QLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQK 300
Query: 301 QWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDK 360
QWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDK
Sbjct: 301 QWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDK 360
Query: 361 KNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEV 420
KNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEV
Sbjct: 361 KNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEV 420
Query: 421 NRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHT 480
NRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHT
Sbjct: 421 NRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHT 480
Query: 481 SSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLI 540
SSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLI
Sbjct: 481 SSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLI 540
Query: 541 QDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQL 600
QDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQL
Sbjct: 541 QDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQL 600
Query: 601 DDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSL 660
DDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSL
Sbjct: 601 DDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSL 660
Query: 661 ASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQ 720
ASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQ
Sbjct: 661 ASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQ 720
Query: 721 QLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEV 780
QLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEV
Sbjct: 721 QLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEV 780
Query: 781 HQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRA 840
HQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRA
Sbjct: 781 HQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRA 840
Query: 841 HVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHR 900
HVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHR
Sbjct: 841 HVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHR 900
Query: 901 ANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKES 960
ANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKES
Sbjct: 901 ANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKES 960
Query: 961 LQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKN 1020
LQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKN
Sbjct: 961 LQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKN 1020
Query: 1021 AGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKE 1080
AGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKE
Sbjct: 1021 AGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKE 1080
Query: 1081 GAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEER 1140
GAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEER
Sbjct: 1081 GAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEER 1140
Query: 1141 LIELLRDKDALWQKSDALEFQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHCRICGR 1200
LIELLRDKDALWQKSDALEFQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHCRICGR
Sbjct: 1141 LIELLRDKDALWQKSDALEFQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHCRICGR 1200
Query: 1201 IFCYYCCNNYVLSKHGGKKERCCRACFQKLSEGPGSPDSSGSGTSQGEPSPALSPASPGP 1260
IFCYYCCNNYVLSKHGGKKERCCRACFQKLSEGPGSPDSSGSGTSQGEPSPALSPASPGP
Sbjct: 1201 IFCYYCCNNYVLSKHGGKKERCCRACFQKLSEGPGSPDSSGSGTSQGEPSPALSPASPGP 1260
Query: 1261 QATGGQGANTDYRPPDDAVFDIITDEELCQIQESGSSLPETPTETDSLDPNAAEQDTTST 1320
QATGGQGANTDYRPPDDAVFDIITDEELCQIQESGSSLPETPTETDSLDPNAAEQDTTST
Sbjct: 1261 QATGGQGANTDYRPPDDAVFDIITDEELCQIQESGSSLPETPTETDSLDPNAAEQDTTST 1320
Query: 1321 SLTPEDTEDMPVGQDSEICLLKSGELMIKVPLTVDEIASFGEGSRELFVRSSTYSLIPIT 1380
SLTPEDTEDMPVGQDSEICLLKSGELMIKVPLTVDEIASFGEGSRELFVRSSTYSLIPIT
Sbjct: 1321 SLTPEDTEDMPVGQDSEICLLKSGELMIKVPLTVDEIASFGEGSRELFVRSSTYSLIPIT 1380
Query: 1381 VAEAGLTISWVFSSDPKSISFSVVFQEAEDTPLDQCKVLIPTTRCNSHKENIQGQLKVRT 1440
VAEAGLTISWVFSSDPKSISFSVVFQEAEDTPLDQCKVLIPTTRCNSHKENIQGQLKVRT
Sbjct: 1381 VAEAGLTISWVFSSDPKSISFSVVFQEAEDTPLDQCKVLIPTTRCNSHKENIQGQLKVRT 1440
Query: 1441 PGIYMLIFDNTFSRFVSKKVFYHLTVDRPVIYDGSDFL 1478
PGIYMLIFDNTFSRFVSKKVFYHLTVDRPVIYDGSDFL
Sbjct: 1441 PGIYMLIFDNTFSRFVSKKVFYHLTVDRPVIYDGSDFL 1478
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 192 bits (489), Expect = 2e-48
Identities = 247/1072 (23%), Positives = 455/1072 (42%), Gaps = 162/1072 (15%)
Query: 234 EMRLELDQLEVREKQLRERMQQ--LDRENQ--ELRAAVSQQGEQLQTERERGRTAAEDNV 289
E +L + R K+ R+ + +D+E Q +L+ +S+ EQL +E+ + E
Sbjct: 425 ETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQL---KEKVTNSTELQH 481
Query: 290 RLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQ 349
+L + Q+Q + Q+T ++E Q L+ + +K++ ++ LE++LQ +
Sbjct: 482 QLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK----IQNLEALLQKSKE 537
Query: 350 E---LEATRDSLDKKNQHLASFPGWLAMAQQKADTASDT---------------KGRQEP 391
LE R+ L K Q L Q+K T + K QE
Sbjct: 538 NISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQEN 597
Query: 392 IPSDAAQEMQELGEKLQALERERTKVEEVNRQQS------AQLEQLVK---ELQLKEDAR 442
+ ++ L + T V E+N Q + +QL+ +K EL L +A
Sbjct: 598 LHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAA 657
Query: 443 ASLER--LVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEE 500
+ +R L + Q L K QE +++ +L ++ A +E ++L K+ +E+
Sbjct: 658 KTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEK 717
Query: 501 KELLEQEVRSLTRQLQFLETQLAQVS----QHVSDLEEQKKQLIQDKD----HLSQQVGM 552
LEQ+ L Q++ LE +V Q + DL++Q+ QL D + LS+Q+ M
Sbjct: 718 YLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQR-QLNTDLELRATELSKQLEM 776
Query: 553 LERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQ---EAQLDDTKVQEGS 609
+ + +L +K+EAL S+++ K EEE++ L+ E +TK+Q
Sbjct: 777 EKEIVSSTRLDLQ---KKSEAL----ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEE 829
Query: 610 QEEELRQANRELEK----------ELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGS 659
++ EL+K EL V + + L+ +++++ Q+ A +
Sbjct: 830 LNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKA---A 886
Query: 660 LASLEAEQASIRH-LGDQMEASLL-------AVRKAKEA----------MKAQMAEKEAI 701
+ LE ++H L QME +L ++ K KEA M+ Q+ + +
Sbjct: 887 ILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNT 946
Query: 702 LQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTD 761
L+ E E QQL+ + + +Q +E + +++ AL+ + + I VL + + +
Sbjct: 947 LKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK-----IAVLQKTELENKLQQQLT 1001
Query: 762 NEARELAAQ---LALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEA 818
A+ELAA+ +++ Q E Q ++LQ+ ++++ A D V+ +LS+A+
Sbjct: 1002 QAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE 1061
Query: 819 VLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELS 878
L ++ Q+ QN+ +QEL + L+++ A + QQ +E +ALQ+
Sbjct: 1062 DLISNRN---QIGNQNKL-----IQEL---KTAKATLEQDSAKKEQQLQERCKALQDIQK 1110
Query: 879 QAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKE 938
+ +E E ++L E + K R E+ + +EL+ K
Sbjct: 1111 EKSLKEKELVNEKSKLAE------------------IEEIKCRQEKEITKLNEELKSHKL 1152
Query: 939 AASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQ 998
+ +E L+ L Q+K LQ K + KAA Q L + + + +E +
Sbjct: 1153 ESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQIL---KDQVKKEEEELKK 1209
Query: 999 ELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGE 1058
E + +L +EI + + +K E L Q+ L ++ + + +++ +
Sbjct: 1210 EFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEK 1269
Query: 1059 KLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRER 1118
+ +A +A + E AL E + + E+EK TK+ E KL
Sbjct: 1270 QTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL--------- 1320
Query: 1119 NDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEERWLGDTEANH 1178
+ T ++E L +++ +L+ + + +W D E +
Sbjct: 1321 ------------DNTTAAVQE-----------LGRENQSLQIKHTQALNRKWAEDNEVQN 1357
Query: 1179 CLDCKREFSWMVRRHHCRICGRIFCYYCCNNYVLSKHGGKKERCCRACFQKL 1230
C+ C + FS VRRHHCR CG IFC C L+ K R C ACF L
Sbjct: 1358 CMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDACFNDL 1409
Score = 126 bits (316), Expect = 2e-28
Identities = 178/778 (22%), Positives = 317/778 (40%), Gaps = 71/778 (9%)
Query: 398 QEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQE 457
QE+Q+L L+ + ++++ + +Q K L D+ A L+ L +++ Q
Sbjct: 90 QEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQT 149
Query: 458 ELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQL-- 515
E Q D ++ +L E+A+++ + +++ +E EQ+V LT +L
Sbjct: 150 ENFNIKQMKDLFEQKAAQLAT-------EIADIKSKYDEERSLREAAEQKVTRLTEELNK 202
Query: 516 -----QFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEK 570
Q L+T+L Q + D+ KK+L+Q + + ER + E +
Sbjct: 203 EATVIQDLKTELLQ-RPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQ 261
Query: 571 NEALVPVNSSLQEAWGK-PEEEQRGLQEAQLDDTKVQEGSQEEELRQAN--------REL 621
+ S L+ K P+E +QE Q + V E +Q+ + N +L
Sbjct: 262 YASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKL 321
Query: 622 EKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASL 681
E++ + ++ L D Q LQ R SA + SL + E + +++ L
Sbjct: 322 EEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEEL 381
Query: 682 LAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQT 741
V + +KA+ + + + KE QL+ E+ Q R+L + ++Q
Sbjct: 382 SEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQR 441
Query: 742 QLIEVLTAEKGQQGVG-----PPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQ 796
QL +K QQ + + +E Q QL+ + + Q QA
Sbjct: 442 QLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTT 501
Query: 797 AKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEAL--NRAHVQELLQCSEREGA 854
AK+R A +D ++V Q+ + ++ + L+Q+ KE L R + +Q E E A
Sbjct: 502 AKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETA 561
Query: 855 LQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCA 914
+ Q +E+ LQE+++Q + H + QE LH ++ Q
Sbjct: 562 V-------LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLH------DQVQEQKAH 608
Query: 915 LTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGS 974
L ++RV +L +V EL + + L+ Q+ + K L +AAK A
Sbjct: 609 LRAAQDRV-LSLETSVNELNSQLNESKEKVSQLDIQI----KAKTELLLSAEAAKTAQ-- 661
Query: 975 LPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEE 1034
+A L AQ+ + QELN + QL ++L++ E C L L+E
Sbjct: 662 ----RADLQNHLDTAQNALQDKQQELNKITTQLD----QVTAKLQDKQEHCSQLESHLKE 713
Query: 1035 QGRQLQAAEEAVEKL----KATQADMGEKLSCTSNHLAEC-QAAMLRKDKE--GAALRED 1087
+ + E+ E+L K +AD E + L + Q L D E L +
Sbjct: 714 YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ 773
Query: 1088 LERTQKELEKAT----TKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERL 1141
LE +KE+ +T K E + Q++T +E Q + D + L++ K E L
Sbjct: 774 LE-MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEEL 830
Score = 125 bits (313), Expect = 4e-28
Identities = 199/936 (21%), Positives = 393/936 (41%), Gaps = 129/936 (13%)
Query: 323 ELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSL-DKKNQHLASFPGWLAMAQQKADT 381
+L A+ KEE +++ + E Q+ EA D L + L S L AQ +
Sbjct: 94 DLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFN 153
Query: 382 ASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDA 441
K E + A E+ ++ K + ER+ E ++ + E+L KE + +D
Sbjct: 154 IKQMKDLFEQKAAQLATEIADIKSKY---DEERSLREAAEQKVTRLTEELNKEATVIQDL 210
Query: 442 RASLERL--VKEMAPLQEEL-----------SGKGQEADQLWRRLQELLAHTSSWEEELA 488
+ L + ++++A L++EL + +E+++L ++L + +S E ++
Sbjct: 211 KTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATIS 270
Query: 489 ELRRE--KKQQQ-----EEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQ------ 535
+LR E K Q+ +E + L+ V LT++ Q L L + Q + LEE+
Sbjct: 271 QLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESV 330
Query: 536 KKQLIQ--------DKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGK 587
K+ IQ D L ++ E EL GE + L S ++ +
Sbjct: 331 SKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQH 390
Query: 588 PEEEQRGLQEAQLDDTKVQEGSQ-EEELRQANREL---EKELQNVVGR----NQLLEGKL 639
+ E + LQ+ + + K Q G Q + E+ Q + +L E++L GR QL KL
Sbjct: 391 LKAEFKQLQQQR--EEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKL 448
Query: 640 QALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKE 699
+ LQ + S ++ L ++H D+ K Q E++
Sbjct: 449 MDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDK--------------TKQQHQEQQ 494
Query: 700 AILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAE------KGQ 753
A+ QS + ++ + ++EQ + + ++++ LE+ Q+ + I +L E K Q
Sbjct: 495 ALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQ 554
Query: 754 QGVGPPT--------DNEARELAAQLALS-QAQLEVHQGEVQRLQAQVVDLQAKMRAALD 804
G G ++ +E QL + Q E H+ + L QV + +A +RAA D
Sbjct: 555 AGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQD 614
Query: 805 DQDKVQSQLSMAEAVLREHKTLVQQL----KEQNEALNRAHVQELLQCSEREGALQEERA 860
+++ ++ + L E K V QL K + E L A + Q ++ + L +
Sbjct: 615 RVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHL-DTAQ 673
Query: 861 DEAQQREEELRALQEELSQA---------KCSSEEAQLEHAELQEQLHRANTDTAELGIQ 911
+ Q +++EL + +L Q CS E+ L+ E +E+ T EL Q
Sbjct: 674 NALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK--EYKEKYLSLEQKTEELEGQ 731
Query: 912 VCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAA 971
+ L + V+ + A+Q+LQ ++ + L+ EKE + +
Sbjct: 732 IKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK 791
Query: 972 AGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQ 1031
+ +L ++ +L + E+ Q L++ D+++ + + + L +
Sbjct: 792 SEALESIKQKLTKQEEEKQILKQ------------------DFETLSQETKIQHEELNNR 833
Query: 1032 LEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERT 1091
++ +LQ + E L + + +KLS S+ L ++ +++++G A DLE+T
Sbjct: 834 IQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKT 893
Query: 1092 ------------------QKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRT 1133
QKEL+K+ K +E ++L E+ + + + L +
Sbjct: 894 CKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953
Query: 1134 KKYLEERLIELLRDKDALWQKSDALEFQQKLSAEER 1169
++ L+ + EL + + ++ +AL+ + K++ ++
Sbjct: 954 EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQK 989
Score = 100 bits (250), Expect = 8e-21
Identities = 130/591 (21%), Positives = 259/591 (43%), Gaps = 66/591 (11%)
Query: 614 LRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHL 673
LRQ ++L+ L+ ++ L+ +L+ YQ LQQ+E+ G + AE S+
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEK----YQGLQQQEAKPDGLVTDSSAELQSLEQQ 143
Query: 674 GDQMEASLLAVRKAK---EAMKAQMAEKEAILQSKEGECQQLREEVEQ-CQQLAEARHRE 729
++ + +++ K E AQ+A + A ++SK E + LRE EQ +L E ++E
Sbjct: 144 LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKE 203
Query: 730 ---LRALESQCQQQTQLIEVLTAEKGQQGVGPPTDN--------------EARELAAQLA 772
++ L+++ Q+ + +V +K V DN E ++L +Q A
Sbjct: 204 ATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYA 263
Query: 773 LSQAQLEVHQGEV----QRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQ 828
S+A + + E+ Q + V +LQ K++++++ + Q ++ E +L++ + +
Sbjct: 264 SSEATISQLRSELAKGPQEVAVYVQELQ-KLKSSVN--ELTQKNQTLTENLLKKEQDYTK 320
Query: 829 -QLKEQNEALNRAHVQEL-----LQCSEREGALQEERAD------EAQQREEELRALQEE 876
+ K E++++ ++Q L C + + L E ++ E + L+EE
Sbjct: 321 LEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEE 380
Query: 877 LSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDA 936
LS+ + + + E +LQ+Q +L ++ L + E L A L++
Sbjct: 381 LSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQ 440
Query: 937 KEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAA 996
++ +S + E+QVA LQ + L+E+LK + LQ QL + +Q+
Sbjct: 441 RQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTE---LQHQLDKTKQQ-------- 489
Query: 997 HQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADM 1056
HQE L+ +A++ + Q+ L+ + +++ LQ ++E + L+ + D+
Sbjct: 490 HQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDL 549
Query: 1057 GEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNR 1116
K+ E + A+L + L+E Q+++ + T K++ Q N
Sbjct: 550 YAKIQA-----GEGETAVLNQ------LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENL 598
Query: 1117 ERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAE 1167
Q+ A L LE + EL + +K L+ Q K E
Sbjct: 599 HDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE 649
Score = 59.7 bits (143), Expect = 2e-08
Identities = 85/419 (20%), Positives = 167/419 (39%), Gaps = 69/419 (16%)
Query: 804 DDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQE-----LLQCSEREGALQEE 858
DD ++ ++ +A L+E K ++LK++ E QE L+ S E E+
Sbjct: 83 DDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQ 142
Query: 859 RADEAQ------------------QREEELRALQEELSQAKCSSEEAQLEHAELQEQLHR 900
+ +EAQ Q E+ ++ + + + E A+ + L E+L++
Sbjct: 143 QLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNK 202
Query: 901 ANTDTAEL--------GIQVCA---------------LTVEKERVEEALACAVQELQDAK 937
T +L GI+ A +T+E+ER E L ++LQ
Sbjct: 203 EATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQY 262
Query: 938 EAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL----PGLQAQLAQAEQRAQSLQ 993
++ L ++A QE ++L+ K++ L L L + EQ L+
Sbjct: 263 ASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLE 322
Query: 994 EAAHQE------LNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVE 1047
E ++E + Q + QSRL + + +L E+G EA +
Sbjct: 323 EKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKG-------EATQ 375
Query: 1048 KLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYN 1107
KLK +++ K + Q K++ G L+ ++ + +L + ++ E +
Sbjct: 376 KLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHG 435
Query: 1108 KLCQEVTNRERNDQKML---ADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQK 1163
+L ++ R+ + +K++ + DL LEE+L E + + L + D + Q +
Sbjct: 436 RLKEQ---RQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQ 491
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 163 bits (412), Expect = 1e-39
Identities = 230/1044 (22%), Positives = 447/1044 (42%), Gaps = 159/1044 (15%)
Query: 227 EALEGFDEMRLELDQLEVREKQLRER--MQQLDRENQELRAAVSQQGEQLQTERERGRTA 284
E L+ DE + L+V+EKQ + +++++R++Q+L + EQLQ E E A
Sbjct: 852 EELQAKDE-----ELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEA 906
Query: 285 AEDNVRLTC-----------LVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKE--- 330
E RL L + ++++ E Q QN K++Q +Q LE E+E
Sbjct: 907 EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGAR 966
Query: 331 EDYHTALRRLESMLQPLAQELEATRDSLDK-------KNQHLASFPGWLAMAQQKADTAS 383
+ E+ ++ + +E+ D K +A LA ++KA +
Sbjct: 967 QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 1026
Query: 384 DTKGRQEPIPSDAAQEM-------QELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQ 436
+ +QE + SD + + QEL + + L+ E T +++ + AQ+++L +L
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA 1086
Query: 437 LKED------ARASLERLVK------------EMAPLQEELSGKGQEADQLWRRLQELLA 478
KE+ AR E L K ++A LQE+ + ++ ++ ++L
Sbjct: 1087 KKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSE 1146
Query: 479 HTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQ 538
+ + EL + QQE + EQEV L + L+ + H + +++ +++
Sbjct: 1147 ELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE------EETKNHEAQIQDMRQR 1200
Query: 539 LIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEA 598
+ LS+Q+ +R N+ L LQ+ + E +++ L +A
Sbjct: 1201 HATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL-DA 1259
Query: 599 QLDD--TKVQEGSQ-EEELRQANRELEKELQNVVGRNQLLEGK----------LQALQAD 645
Q+ + KV EG + EL + +L+ EL NV + E K L++ D
Sbjct: 1260 QVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQD 1319
Query: 646 YQALQQRESAIQGSLAS----LEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAI 701
Q L Q E+ + +L+S LE E+ S++ ++ E + + K A+++Q+A+ +
Sbjct: 1320 TQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKK 1379
Query: 702 LQSKEGECQQLREEVEQCQQLAEARHRELR-------ALESQCQQQTQLIEVLTAEKGQQ 754
+ G + L E ++ + AEA + L LE + Q ++ LT + Q
Sbjct: 1380 VDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQ 1439
Query: 755 GVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLS 814
R++A+ L Q + + E + + A+ + + RA + ++K LS
Sbjct: 1440 ----------RQVASNLEKKQKKFDQLLAEEKSISARYA--EERDRAEAEAREKETKALS 1487
Query: 815 MAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQ 874
+A A L E ++ + QN+ L RA +++L+ + G + E+ RAL+
Sbjct: 1488 LARA-LEEALEAKEEFERQNKQL-RADMEDLMSSKDDVG-------KNVHELEKSKRALE 1538
Query: 875 EELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQ 934
+++ EE + + EL+++L L + + A+ + ER +LQ
Sbjct: 1539 QQV-------EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER----------DLQ 1581
Query: 935 DAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQE 994
E ++ L +QV L+ E L+++ K A S ++ L E + ++ +
Sbjct: 1582 TRDEQNEEKKRLLIKQVRELEAE---LEDERKQRALAVASKKKMEIDLKDLEAQIEAANK 1638
Query: 995 AAHQELNTLKFQLSAEIMDYQSRL--------------KNAGEECKSLRGQLEEQGRQLQ 1040
A + + L+ +L A++ DYQ L K + ++ KSL ++ + +L
Sbjct: 1639 ARDEVIKQLR-KLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELA 1697
Query: 1041 AAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELE---- 1096
++E A + + ++ ++++ +++ + R + A L E+LE Q +E
Sbjct: 1698 SSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLND 1757
Query: 1097 ---KATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIEL---LRDK-- 1148
K T ++ +L E + +++D L R K L+ +L EL ++ K
Sbjct: 1758 RFRKTTLQVDTLNAELAAERSAAQKSDNAR----QQLERQNKELKAKLQELEGAVKSKFK 1813
Query: 1149 ---DALWQKSDALEFQQKLSAEER 1169
AL K LE Q + A+ER
Sbjct: 1814 ATISALEAKIGQLEEQLEQEAKER 1837
Score = 151 bits (382), Expect = 4e-36
Identities = 215/984 (21%), Positives = 405/984 (41%), Gaps = 101/984 (10%)
Query: 202 SSLVSSYLQTQEMVSNFDLNSPLNNEALEGF-----DEMRLELDQLEV-REKQLRERMQQ 255
+ L + Q + L E L+G DE + + L+V RE Q + Q
Sbjct: 1065 TDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQ 1124
Query: 256 LDRENQEL-RAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKE 314
D E+++ R +Q L E E +T ED + T EL+ + E Q K
Sbjct: 1125 EDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE--QEVAELKKA 1182
Query: 315 LQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQ---ELEATRDSLDKKNQHLASFPGW 371
L+ + E + + + TAL L L+ + LE + L+ N+ LA
Sbjct: 1183 LEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELAC---- 1238
Query: 372 LAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQL 431
+ K E ++QEL K+ E +R +VE + Q E L
Sbjct: 1239 ------EVKVLQQVKAESEHKRKKLDAQVQELHAKVS--EGDRLRVELAEKASKLQNE-L 1289
Query: 432 VKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELR 491
L E+A + K+ A L+ +L Q+ +L LQE + + +L
Sbjct: 1290 DNVSTLLEEAEKKGIKFAKDAASLESQL----QDTQEL---LQEETRQKLNLSSRIRQLE 1342
Query: 492 REKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSD-------LEEQKKQLIQDKD 544
EK QE++E E+ ++L +Q+ L++QLA + V D LEE KK+L++D +
Sbjct: 1343 EEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE 1402
Query: 545 HLSQQV-------GMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQE 597
LSQ++ LE+ EL ++ V ++ Q A E++Q+ +
Sbjct: 1403 ALSQRLEEKALAYDKLEKTKNRLQQEL------DDLTVDLDHQRQVA-SNLEKKQKKFDQ 1455
Query: 598 AQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQ 657
++ + EE R EKE + + L +AL+A + +++ ++
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKAL----SLARALEEALEAK-EEFERQNKQLR 1510
Query: 658 GSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVE 717
+ L + + + ++E S A+ + E M+ Q+ E E LQ+ E +LR EV
Sbjct: 1511 ADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATED--AKLRLEVN 1568
Query: 718 QCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQ 777
Q + R+L+ + Q +++ +L+ + REL A+L + Q
Sbjct: 1569 M-QAMKAQFERDLQTRDEQNEEKKRLL----------------IKQVRELEAELEDERKQ 1611
Query: 778 LEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEAL 837
+ ++++ + DL+A++ AA +D+V QL +A +++++ +E EA
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQ------RELEEA- 1664
Query: 838 NRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQ 897
RA E+ A +E + + E E+ LQEEL+ ++ + A+ E EL ++
Sbjct: 1665 -RASRDEIF-------AQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADE 1716
Query: 898 LHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQE 957
+ + + + AL EK R+E +A +EL++ + + + +
Sbjct: 1717 ITNSASGKS-------ALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTL 1769
Query: 958 KESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSR 1017
L + AA+ + + L+ Q + + + Q L+ A + L A+I + +
Sbjct: 1770 NAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQ 1829
Query: 1018 LKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRK 1077
L+ +E + + ++L+ VE + E++ + + + + +
Sbjct: 1830 LEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEA 1889
Query: 1078 DKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYL 1137
++E + Q+EL+ A T+ E ++ + NR R + R + +L
Sbjct: 1890 EEEATRANASRRKLQRELDDA-TEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHL 1948
Query: 1138 EERLIELLRDKDALWQKSDALEFQ 1161
E +E L D D + SD E Q
Sbjct: 1949 EGASLE-LSDDDTESKTSDVNETQ 1971
Score = 132 bits (333), Expect = 2e-30
Identities = 164/707 (23%), Positives = 317/707 (44%), Gaps = 90/707 (12%)
Query: 522 LAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSL 581
L QV++ +L+ + ++L++ K+ ++ G LE + K++ L+ + L
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEME-----------RKHQQLLEEKNIL 892
Query: 582 QEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQA 641
E E A+ ++ + + ++++EL + +LE ++ RNQ+L+ + +
Sbjct: 893 AEQLQAETE-----LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKK 947
Query: 642 LQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAI 701
+QA Q L+++ +G+ L+ E+ + +ME +L + E ++ +++ +
Sbjct: 948 MQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLL----EDQNSKFIKEKKL 1003
Query: 702 LQSKEGEC-QQLREEVEQCQQLAEARHRE---LRALESQCQQQTQLIEVLTAEKGQQGVG 757
++ + EC QL EE E+ + LA+ R+++ + LE + +++ + + L K +
Sbjct: 1004 MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK---- 1059
Query: 758 PPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAE 817
D E +L Q+A QAQ++ L+ Q+ + +++ AL D + A
Sbjct: 1060 --LDGETTDLQDQIAELQAQID-------ELKLQLAKKEEELQGALARGDDETLHKNNAL 1110
Query: 818 AVLREHKTLVQQLKEQNE----ALNRAHVQ-------------ELLQCSEREGALQEERA 860
V+RE + + +L+E E + N+A Q EL + A QE R
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRT 1170
Query: 861 DEAQQREEELRALQEELSQAKCSSEEAQLEHA----ELQEQLHRANTDTAELGIQVCALT 916
Q+ E +AL+EE + ++ + HA EL EQL +A A L L
Sbjct: 1171 KREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLE 1230
Query: 917 VEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQ---QEKESLQEKL-KAAKAAA 972
+ + LAC V+ LQ K + +R+ L+ QV L E + L+ +L + A
Sbjct: 1231 TDNKE----LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286
Query: 973 GSLPGLQAQLAQAEQR-------AQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEEC 1025
L + L +AE++ A SL E+ Q+ L + + + ++ SR++ EE
Sbjct: 1287 NELDNVSTLLEEAEKKGIKFAKDAASL-ESQLQDTQELLQEETRQKLNLSSRIRQLEEEK 1345
Query: 1026 KSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALR 1085
SL+ Q EE+ + E+ V L++ AD +K+ + + A + K+ AL
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405
Query: 1086 EDLER---TQKELEKATTKIQEYYNKLCQEVTNRER---NDQKMLADLDDLNRTKKYLEE 1139
+ LE +LEK ++Q+ + L ++ ++ + N +K D L +K +
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465
Query: 1140 RLIELLRDKDALWQKSDALEFQQKLSAEERWLGDTEANHCLDCKREF 1186
R E RD+ +++A E + K + R L L+ K EF
Sbjct: 1466 RYAE-ERDR----AEAEAREKETKALSLARAL-----EEALEAKEEF 1502
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 163 bits (412), Expect = 1e-39
Identities = 221/992 (22%), Positives = 426/992 (42%), Gaps = 149/992 (15%)
Query: 224 LNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRT 283
L E L+ E+ E +++ VR ++ ++++ E + +G+QLQ ER+
Sbjct: 891 LLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK---- 946
Query: 284 AAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKE----EDYHTAL-- 337
++ + +L++Q E +A + + +L+ ++ E E +D + L
Sbjct: 947 ------KMAQQMLDLEEQLEEEEAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSK 999
Query: 338 ------RRLESMLQPLAQELEATRDSLDKKNQH---LASFPGWLAMAQQKADTASDTKGR 388
R+ + LA+E E ++ KN+H ++ L ++ K +
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1059
Query: 389 QEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERL 448
E SD +++ +L ++ L+ + K EE + A L +L E+ K +A + L
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEE---ELQAALARLDDEIAQKNNALKKIREL 1116
Query: 449 VKEMAPLQEELSGK--------------GQEADQLWRRLQELLAHTSSWEEELAELRREK 494
++ LQE+L + G+E + L L++ L T++ + ELR ++
Sbjct: 1117 EGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ----ELRAKR 1172
Query: 495 KQQQEE-KELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGML 553
+Q+ K+ L++E RS Q+Q + + AQ V +L EQ +Q + K +L + L
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQA---VEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 554 ERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQ-EE 612
E+ EL V G+ + QE K ++ + +QE Q +K +G +
Sbjct: 1230 EKENADLAGELRVLGQ----------AKQEVEHKKKKLEAQVQELQ---SKCSDGERARA 1276
Query: 613 ELRQANRELEKELQNVVGRNQLLEGK----------LQALQADYQALQQRESA----IQG 658
EL +L+ E+++V G EGK L + D Q L Q E+ +
Sbjct: 1277 ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST 1336
Query: 659 SLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQ 718
L LE E+ S++ DQ++ + +AK+ ++ ++ L + + Q VE
Sbjct: 1337 KLRQLEEERNSLQ---DQLDEEM----EAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 719 CQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQ-----QGVGPPTDNEARELAAQLAL 773
++ + +E+ L Q +++ + L K + + DN+ R+L + L
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEK 1448
Query: 774 SQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQ 833
Q + + E + + ++ D + RA + ++K LS+A A L E ++L+
Sbjct: 1449 KQRKFDQLLAEEKNISSKYAD--ERDRAEAEAREKETKALSLARA-LEEALEAKEELERT 1505
Query: 834 NEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAE 893
N+ L +A +++L+ + G + E+ RAL+ ++ + K QLE E
Sbjct: 1506 NKML-KAEMEDLVSSKDDVG-------KNVHELEKSKRALETQMEEMK-----TQLE--E 1550
Query: 894 LQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAG 953
L+++L L + + AL + ER +LQ E +R L+RQ
Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFER----------DLQARDEQNEEKRRQLQRQ--- 1597
Query: 954 LQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMD 1013
L + + L+++ K AA + L+ L E +A S + + + L+ +L A++ D
Sbjct: 1598 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR-KLQAQMKD 1656
Query: 1014 YQSRLKNA--------------GEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEK 1059
+Q L++A ++ KSL L + L AAE A ++ + ++ E+
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 1060 LSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELE-------KATTKIQEYYNKLCQE 1112
L+ + + Q R + A L E+LE Q +E KAT + ++ N+L E
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Query: 1113 VTNRERNDQKMLADLDDLNRTKKYLEERLIEL 1144
+ ++N+ L R K L +L E+
Sbjct: 1777 RSTAQKNESAR----QQLERQNKELRSKLHEM 1804
Score = 149 bits (377), Expect = 1e-35
Identities = 217/1000 (21%), Positives = 428/1000 (42%), Gaps = 161/1000 (16%)
Query: 212 QEMVSNFDLNSPLNNEALEGFDEMRLE----LDQLEVREKQLRERMQQLDRENQELRAAV 267
+E +S+ N E + +++ + + +LEVR K+ + Q+L++ ++L
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1064
Query: 268 SQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAA 327
S EQ+ L +AEL+ Q + +ELQ L L+ A
Sbjct: 1065 SDFHEQIAD--------------LQAQIAELKMQLAKKE------EELQAALARLDDEIA 1104
Query: 328 EKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKG 387
+K +R LE + L ++L++ R + +K + L + + + D+
Sbjct: 1105 QKNNALKK-IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1163
Query: 388 RQEPIPSDAAQEMQELGEKLQALERER-TKVEEVNRQQSAQLEQLVKELQLKEDARASLE 446
Q+ + + QE+ L + L R +V+E+ ++ + +E+L ++L+ + A+A+L+
Sbjct: 1164 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 447 R----LVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKE 502
+ L KE A L EL GQ ++ + ++L A + + ++ R + + ++
Sbjct: 1224 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1283
Query: 503 LLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGP 562
L+ EV S+T L E + ++++ V+ L Q +QD L Q+
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ----LQDTQELLQE---------ETRQ 1330
Query: 563 ELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQE------AQLDDTK--VQE-GSQEEE 613
+L V+ K L +SLQ+ + E ++ L+ QL D+K +Q+ S E
Sbjct: 1331 KLNVS-TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 614 LRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHL 673
L + + +KE++N+ Q E K A Y L++ ++ +Q L L + + R L
Sbjct: 1390 LEEGKKRFQKEIENLT---QQYEEKAAA----YDKLEKTKNRLQQELDDLVVDLDNQRQL 1442
Query: 674 GDQMEAS------LLAVRK---AKEAMKAQMAEKEAILQSKEG--------ECQQLREEV 716
+E LLA K +K A + AE EA + + E + +EE+
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 717 EQCQQLAEARHREL------------------RALESQCQQ-QTQLIEV----------- 746
E+ ++ +A +L RALE+Q ++ +TQL E+
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 747 ------LTAEKGQ-----QGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDL 795
+ A KGQ Q + + R+L QL + +LE + ++ +A
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE----DERKQRALAAAA 1618
Query: 796 QAKMRAALDDQD-KVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGA 854
+ K+ L D + + S + E +++ + L Q+K+ L A + A
Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR-----DEIFA 1673
Query: 855 LQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCA 914
+E +A+ E +L LQE+L+ A+ + ++A LE EL E+L + + A
Sbjct: 1674 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN-------A 1726
Query: 915 LTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGS 974
L EK R+E +A +L++ E E + +V Q+ E L +L ++ A
Sbjct: 1727 LQDEKRRLEARIA----QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782
Query: 975 LPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEE 1034
+ QL E++ + L+ H+ +K + + I ++++ L Q+E+
Sbjct: 1783 NESARQQL---ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI-------AQLEEQVEQ 1832
Query: 1035 QGRQLQAAEEAV----EKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLER 1090
+ R+ QAA +++ +KLK + ++ + + + +G A + L+R
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE--------KGNARVKQLKR 1884
Query: 1091 TQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDL 1130
+E E+ + +I KL +E+ +++ M +++ L
Sbjct: 1885 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1924
Score = 139 bits (351), Expect = 2e-32
Identities = 207/894 (23%), Positives = 391/894 (43%), Gaps = 147/894 (16%)
Query: 376 QQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKEL 435
Q K D TK RQ+ A E++EL +K L E+ ++E QL E
Sbjct: 855 QAKEDELQKTKERQQK----AENELKELEQKHSQLTEEKNLLQE----------QLQAET 900
Query: 436 QLKEDA----------RASLERLVKEMAPLQEELSGKGQEADQLWRRL-QELLAHTSSWE 484
+L +A + LE ++ EM EE +GQ+ +++ Q++L E
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 485 EELA---ELRREK-------KQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEE 534
EE A +L+ EK K+ ++E +++ + L+++ + LE +++ ++ ++++ EE
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 535 QKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRG 594
+ K L + K+ + LE L + + L + L+ E+
Sbjct: 1021 KAKNLTKLKNKHESMISELE-------VRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073
Query: 595 LQEAQLDDTKVQEGSQEEELRQANRELEKEL---QNVVGRNQLLEGKLQALQADYQALQQ 651
LQ AQ+ + K+Q +EEEL+ A L+ E+ N + + + LEG + LQ D
Sbjct: 1074 LQ-AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED------ 1126
Query: 652 RESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQ 711
+ A+ + R LG+++E A++ E A ++ + +E E
Sbjct: 1127 ----LDSERAARNKAEKQKRDLGEELE----ALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 712 LREEVEQCQQLAEARHRELRALESQC-QQQTQLIEVLTAEKGQQGVGPPT-DNEARELAA 769
L++ +++ + EA+ +E+R +Q ++ T+ +E K T + E +LA
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238
Query: 770 QL-ALSQAQLEVHQGEVQRLQAQVVDLQAK------MRAALDDQ-DKVQSQLSMAEAVLR 821
+L L QA+ EV + + ++L+AQV +LQ+K RA L+D+ K+Q+++ +L
Sbjct: 1239 ELRVLGQAKQEV-EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1297
Query: 822 EHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAK 881
E + +L + +L+ + +Q+ + + E + + + +Q EEE +LQ++L +
Sbjct: 1298 EAEGKAIKLAKDVASLS-SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 882 CSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVE----------EALACAVQ 931
+ + + + L QL + + V AL K+R + E A A
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416
Query: 932 ELQDAKEAASREREGL------ERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQA 985
+L+ K +E + L +RQ+ ++K+ ++L A + S + A+A
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 986 EQR---------AQSLQEA--AHQELNTLKFQLSAEIMDYQSRLKNAGE----------- 1023
E R A++L+EA A +EL L AE+ D S + G+
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1536
Query: 1024 ---ECKSLRGQLEEQGRQLQAAEEAVEKLKAT-QADMG--------------EKLSCTSN 1065
+ + ++ QLEE +LQA E+A +L+ QA G EK
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1596
Query: 1066 HLAECQAAMLRKDKE---GAALREDLERTQKELE-------KATTKIQEYYNKLCQEVTN 1115
L E + + + K+ AA ++ LE K+LE K + + KL ++ +
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656
Query: 1116 RERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEER 1169
+R + A D++ T K E++ L ++D ++ Q+ L+A ER
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSL---------EADLMQLQEDLAAAER 1701
Score = 113 bits (283), Expect = 1e-24
Identities = 155/688 (22%), Positives = 286/688 (41%), Gaps = 100/688 (14%)
Query: 238 ELDQLEVREK-QLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVA 296
EL Q E R+K + +++QL+ E L+ Q E+++ ++ R + N++L+
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQ---DQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Query: 297 ELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDY---HTALRRLESMLQPLAQELEA 353
+LQ +A + K Q ++ L EK Y RL+ L L +L+
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 354 TRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERE 413
R + + F LA + + +D + R E + + L L+
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 414 RTKVEEVNRQQSAQLEQLV-------KELQLKEDARASLERLVKEMAPLQEELSGKGQEA 466
+ ++E N+ A++E LV K + E ++ +LE ++EM EEL + Q
Sbjct: 1499 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1558
Query: 467 DQLWRRLQ-ELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQV 525
+ RL+ + A +E +L + + +Q EEK R L RQL ET+L
Sbjct: 1559 EDAKLRLEVNMQALKGQFERDL----QARDEQNEEKR------RQLQRQLHEYETELEDE 1608
Query: 526 SQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAW 585
+ + KK+L D L Q + + G + EA+ L++
Sbjct: 1609 RKQRALAAAAKKKLEGDLKDLELQA------------DSAIKG-REEAI----KQLRKLQ 1651
Query: 586 GKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQAD 645
+ ++ QR L++A+ + +E+ +E EK+ ++ LE L LQ D
Sbjct: 1652 AQMKDFQRELEDAR---------ASRDEIFATAKENEKKAKS-------LEADLMQLQED 1695
Query: 646 YQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLL---AVRKAKEAMKAQMAEKEAIL 702
A ++ A LE E+ L +++ +SL A++ K ++A++A+ E L
Sbjct: 1696 LAAAERARKQ-----ADLEKEE-----LAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1745
Query: 703 QSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDN 762
+ ++G + + + V + Q AE EL S Q+ + L +
Sbjct: 1746 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL-------------ER 1792
Query: 763 EARELAAQL-ALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLR 821
+ +EL ++L + A + + L+A++ L+ ++ ++ L + L+
Sbjct: 1793 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1852
Query: 822 E-------HKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQ 874
E + + +Q KEQ E N A V++L + EE +E+Q+ R LQ
Sbjct: 1853 EILLQVEDERKMAEQYKEQAEKGN-ARVKQLKR-------QLEEAEEESQRINANRRKLQ 1904
Query: 875 EELSQAKCSSEEAQLEHAELQEQLHRAN 902
EL +A S+E E L+ +L R N
Sbjct: 1905 RELDEATESNEAMGREVNALKSKLRRGN 1932
Score = 98.2 bits (243), Expect = 5e-20
Identities = 163/665 (24%), Positives = 260/665 (39%), Gaps = 148/665 (22%)
Query: 605 VQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLE 664
+Q QEEE++ E ELQ R Q E +L+ L+ + L + ++ +Q L +
Sbjct: 845 LQVTRQEEEMQAK----EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 900
Query: 665 AEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGE----CQQLREEVEQCQ 720
A + ++ A + + M+A++ E+E Q + E QQ+ + EQ +
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 721 QLAEARHR----------ELRALESQCQQQTQLIEVLTAEKG--QQGVGPPTDNEARELA 768
+ AR + +++ LE + L+ E+ ++ + T N A E
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 769 AQLALSQ---------AQLEVH------------------QGEVQRLQAQVVDLQA---- 797
L++ ++LEV +G+ Q+ DLQA
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 798 ----------KMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKE----QNEALNRAHVQ 843
+++AAL D +Q + A +RE + + L+E + A N+A Q
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 844 -------------ELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLE 890
EL + QE RA Q+ +AL EE + +E + +
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200
Query: 891 HA----ELQEQLH-----RANTD---------TAELGIQVCALTVEKERVE---EALACA 929
HA EL EQL +AN D A+L ++ L K+ VE + L
Sbjct: 1201 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 930 VQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQL-AQAEQR 988
VQELQ R R L +V LQ E ES+ L A+ A L A L +Q +
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320
Query: 989 AQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEK 1048
+ LQE Q+LN ++L+ EE SL+ QL+E+ Q E +
Sbjct: 1321 QELLQEETRQKLNV------------STKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368
Query: 1049 LKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNK 1108
L +D +KL ++ + AL E +R QKE+E T Q+Y K
Sbjct: 1369 LNIQLSDSKKKLQDFASTV--------------EALEEGKKRFQKEIENLT---QQYEEK 1411
Query: 1109 LCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQK----L 1164
A D L +TK L++ L +L+ D D Q LE +Q+ L
Sbjct: 1412 ---------------AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1456
Query: 1165 SAEER 1169
AEE+
Sbjct: 1457 LAEEK 1461
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 163 bits (412), Expect = 1e-39
Identities = 221/992 (22%), Positives = 426/992 (42%), Gaps = 149/992 (15%)
Query: 224 LNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRT 283
L E L+ E+ E +++ VR ++ ++++ E + +G+QLQ ER+
Sbjct: 898 LLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK---- 953
Query: 284 AAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKE----EDYHTAL-- 337
++ + +L++Q E +A + + +L+ ++ E E +D + L
Sbjct: 954 ------KMAQQMLDLEEQLEEEEAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSK 1006
Query: 338 ------RRLESMLQPLAQELEATRDSLDKKNQH---LASFPGWLAMAQQKADTASDTKGR 388
R+ + LA+E E ++ KN+H ++ L ++ K +
Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1066
Query: 389 QEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERL 448
E SD +++ +L ++ L+ + K EE + A L +L E+ K +A + L
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEE---ELQAALARLDDEIAQKNNALKKIREL 1123
Query: 449 VKEMAPLQEELSGK--------------GQEADQLWRRLQELLAHTSSWEEELAELRREK 494
++ LQE+L + G+E + L L++ L T++ + ELR ++
Sbjct: 1124 EGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ----ELRAKR 1179
Query: 495 KQQQEE-KELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGML 553
+Q+ K+ L++E RS Q+Q + + AQ V +L EQ +Q + K +L + L
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQA---VEELTEQLEQFKRAKANLDKNKQTL 1236
Query: 554 ERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQ-EE 612
E+ EL V G+ + QE K ++ + +QE Q +K +G +
Sbjct: 1237 EKENADLAGELRVLGQ----------AKQEVEHKKKKLEAQVQELQ---SKCSDGERARA 1283
Query: 613 ELRQANRELEKELQNVVGRNQLLEGK----------LQALQADYQALQQRESA----IQG 658
EL +L+ E+++V G EGK L + D Q L Q E+ +
Sbjct: 1284 ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST 1343
Query: 659 SLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQ 718
L LE E+ S++ DQ++ + +AK+ ++ ++ L + + Q VE
Sbjct: 1344 KLRQLEEERNSLQ---DQLDEEM----EAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 719 CQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQ-----QGVGPPTDNEARELAAQLAL 773
++ + +E+ L Q +++ + L K + + DN+ R+L + L
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEK 1455
Query: 774 SQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQ 833
Q + + E + + ++ D + RA + ++K LS+A A L E ++L+
Sbjct: 1456 KQRKFDQLLAEEKNISSKYAD--ERDRAEAEAREKETKALSLARA-LEEALEAKEELERT 1512
Query: 834 NEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAE 893
N+ L +A +++L+ + G + E+ RAL+ ++ + K QLE E
Sbjct: 1513 NKML-KAEMEDLVSSKDDVG-------KNVHELEKSKRALETQMEEMK-----TQLE--E 1557
Query: 894 LQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAG 953
L+++L L + + AL + ER +LQ E +R L+RQ
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFER----------DLQARDEQNEEKRRQLQRQ--- 1604
Query: 954 LQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMD 1013
L + + L+++ K AA + L+ L E +A S + + + L+ +L A++ D
Sbjct: 1605 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR-KLQAQMKD 1663
Query: 1014 YQSRLKNA--------------GEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEK 1059
+Q L++A ++ KSL L + L AAE A ++ + ++ E+
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 1060 LSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELE-------KATTKIQEYYNKLCQE 1112
L+ + + Q R + A L E+LE Q +E KAT + ++ N+L E
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Query: 1113 VTNRERNDQKMLADLDDLNRTKKYLEERLIEL 1144
+ ++N+ L R K L +L E+
Sbjct: 1784 RSTAQKNESAR----QQLERQNKELRSKLHEM 1811
Score = 149 bits (377), Expect = 1e-35
Identities = 217/1000 (21%), Positives = 428/1000 (42%), Gaps = 161/1000 (16%)
Query: 212 QEMVSNFDLNSPLNNEALEGFDEMRLE----LDQLEVREKQLRERMQQLDRENQELRAAV 267
+E +S+ N E + +++ + + +LEVR K+ + Q+L++ ++L
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1071
Query: 268 SQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAA 327
S EQ+ L +AEL+ Q + +ELQ L L+ A
Sbjct: 1072 SDFHEQIAD--------------LQAQIAELKMQLAKKE------EELQAALARLDDEIA 1111
Query: 328 EKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKG 387
+K +R LE + L ++L++ R + +K + L + + + D+
Sbjct: 1112 QKNNALKK-IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1170
Query: 388 RQEPIPSDAAQEMQELGEKLQALERER-TKVEEVNRQQSAQLEQLVKELQLKEDARASLE 446
Q+ + + QE+ L + L R +V+E+ ++ + +E+L ++L+ + A+A+L+
Sbjct: 1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 447 R----LVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKE 502
+ L KE A L EL GQ ++ + ++L A + + ++ R + + ++
Sbjct: 1231 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1290
Query: 503 LLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGP 562
L+ EV S+T L E + ++++ V+ L Q +QD L Q+
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ----LQDTQELLQE---------ETRQ 1337
Query: 563 ELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQE------AQLDDTK--VQE-GSQEEE 613
+L V+ K L +SLQ+ + E ++ L+ QL D+K +Q+ S E
Sbjct: 1338 KLNVS-TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 614 LRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHL 673
L + + +KE++N+ Q E K A Y L++ ++ +Q L L + + R L
Sbjct: 1397 LEEGKKRFQKEIENLT---QQYEEKAAA----YDKLEKTKNRLQQELDDLVVDLDNQRQL 1449
Query: 674 GDQMEAS------LLAVRK---AKEAMKAQMAEKEAILQSKEG--------ECQQLREEV 716
+E LLA K +K A + AE EA + + E + +EE+
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 717 EQCQQLAEARHREL------------------RALESQCQQ-QTQLIEV----------- 746
E+ ++ +A +L RALE+Q ++ +TQL E+
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 747 ------LTAEKGQ-----QGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDL 795
+ A KGQ Q + + R+L QL + +LE + ++ +A
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE----DERKQRALAAAA 1625
Query: 796 QAKMRAALDDQD-KVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGA 854
+ K+ L D + + S + E +++ + L Q+K+ L A + A
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR-----DEIFA 1680
Query: 855 LQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCA 914
+E +A+ E +L LQE+L+ A+ + ++A LE EL E+L + + A
Sbjct: 1681 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN-------A 1733
Query: 915 LTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGS 974
L EK R+E +A +L++ E E + +V Q+ E L +L ++ A
Sbjct: 1734 LQDEKRRLEARIA----QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789
Query: 975 LPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEE 1034
+ QL E++ + L+ H+ +K + + I ++++ L Q+E+
Sbjct: 1790 NESARQQL---ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI-------AQLEEQVEQ 1839
Query: 1035 QGRQLQAAEEAV----EKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLER 1090
+ R+ QAA +++ +KLK + ++ + + + +G A + L+R
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE--------KGNARVKQLKR 1891
Query: 1091 TQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDL 1130
+E E+ + +I KL +E+ +++ M +++ L
Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1931
Score = 139 bits (351), Expect = 2e-32
Identities = 207/894 (23%), Positives = 391/894 (43%), Gaps = 147/894 (16%)
Query: 376 QQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKEL 435
Q K D TK RQ+ A E++EL +K L E+ ++E QL E
Sbjct: 862 QAKEDELQKTKERQQK----AENELKELEQKHSQLTEEKNLLQE----------QLQAET 907
Query: 436 QLKEDA----------RASLERLVKEMAPLQEELSGKGQEADQLWRRL-QELLAHTSSWE 484
+L +A + LE ++ EM EE +GQ+ +++ Q++L E
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 485 EELA---ELRREK-------KQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEE 534
EE A +L+ EK K+ ++E +++ + L+++ + LE +++ ++ ++++ EE
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 535 QKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRG 594
+ K L + K+ + LE L + + L + L+ E+
Sbjct: 1028 KAKNLTKLKNKHESMISELE-------VRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080
Query: 595 LQEAQLDDTKVQEGSQEEELRQANRELEKEL---QNVVGRNQLLEGKLQALQADYQALQQ 651
LQ AQ+ + K+Q +EEEL+ A L+ E+ N + + + LEG + LQ D
Sbjct: 1081 LQ-AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED------ 1133
Query: 652 RESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQ 711
+ A+ + R LG+++E A++ E A ++ + +E E
Sbjct: 1134 ----LDSERAARNKAEKQKRDLGEELE----ALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 712 LREEVEQCQQLAEARHRELRALESQC-QQQTQLIEVLTAEKGQQGVGPPT-DNEARELAA 769
L++ +++ + EA+ +E+R +Q ++ T+ +E K T + E +LA
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245
Query: 770 QL-ALSQAQLEVHQGEVQRLQAQVVDLQAK------MRAALDDQ-DKVQSQLSMAEAVLR 821
+L L QA+ EV + + ++L+AQV +LQ+K RA L+D+ K+Q+++ +L
Sbjct: 1246 ELRVLGQAKQEV-EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1304
Query: 822 EHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAK 881
E + +L + +L+ + +Q+ + + E + + + +Q EEE +LQ++L +
Sbjct: 1305 EAEGKAIKLAKDVASLS-SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 882 CSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVE----------EALACAVQ 931
+ + + + L QL + + V AL K+R + E A A
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423
Query: 932 ELQDAKEAASREREGL------ERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQA 985
+L+ K +E + L +RQ+ ++K+ ++L A + S + A+A
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 986 EQR---------AQSLQEA--AHQELNTLKFQLSAEIMDYQSRLKNAGE----------- 1023
E R A++L+EA A +EL L AE+ D S + G+
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1543
Query: 1024 ---ECKSLRGQLEEQGRQLQAAEEAVEKLKAT-QADMG--------------EKLSCTSN 1065
+ + ++ QLEE +LQA E+A +L+ QA G EK
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1603
Query: 1066 HLAECQAAMLRKDKE---GAALREDLERTQKELE-------KATTKIQEYYNKLCQEVTN 1115
L E + + + K+ AA ++ LE K+LE K + + KL ++ +
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663
Query: 1116 RERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEER 1169
+R + A D++ T K E++ L ++D ++ Q+ L+A ER
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSL---------EADLMQLQEDLAAAER 1708
Score = 113 bits (283), Expect = 1e-24
Identities = 155/688 (22%), Positives = 286/688 (41%), Gaps = 100/688 (14%)
Query: 238 ELDQLEVREK-QLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVA 296
EL Q E R+K + +++QL+ E L+ Q E+++ ++ R + N++L+
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQ---DQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Query: 297 ELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDY---HTALRRLESMLQPLAQELEA 353
+LQ +A + K Q ++ L EK Y RL+ L L +L+
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 354 TRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERE 413
R + + F LA + + +D + R E + + L L+
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1505
Query: 414 RTKVEEVNRQQSAQLEQLV-------KELQLKEDARASLERLVKEMAPLQEELSGKGQEA 466
+ ++E N+ A++E LV K + E ++ +LE ++EM EEL + Q
Sbjct: 1506 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1565
Query: 467 DQLWRRLQ-ELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQV 525
+ RL+ + A +E +L + + +Q EEK R L RQL ET+L
Sbjct: 1566 EDAKLRLEVNMQALKGQFERDL----QARDEQNEEKR------RQLQRQLHEYETELEDE 1615
Query: 526 SQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAW 585
+ + KK+L D L Q + + G + EA+ L++
Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQA------------DSAIKG-REEAI----KQLRKLQ 1658
Query: 586 GKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQAD 645
+ ++ QR L++A+ + +E+ +E EK+ ++ LE L LQ D
Sbjct: 1659 AQMKDFQRELEDAR---------ASRDEIFATAKENEKKAKS-------LEADLMQLQED 1702
Query: 646 YQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLL---AVRKAKEAMKAQMAEKEAIL 702
A ++ A LE E+ L +++ +SL A++ K ++A++A+ E L
Sbjct: 1703 LAAAERARKQ-----ADLEKEE-----LAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752
Query: 703 QSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDN 762
+ ++G + + + V + Q AE EL S Q+ + L +
Sbjct: 1753 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL-------------ER 1799
Query: 763 EARELAAQL-ALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLR 821
+ +EL ++L + A + + L+A++ L+ ++ ++ L + L+
Sbjct: 1800 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1859
Query: 822 E-------HKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQ 874
E + + +Q KEQ E N A V++L + EE +E+Q+ R LQ
Sbjct: 1860 EILLQVEDERKMAEQYKEQAEKGN-ARVKQLKR-------QLEEAEEESQRINANRRKLQ 1911
Query: 875 EELSQAKCSSEEAQLEHAELQEQLHRAN 902
EL +A S+E E L+ +L R N
Sbjct: 1912 RELDEATESNEAMGREVNALKSKLRRGN 1939
Score = 98.2 bits (243), Expect = 5e-20
Identities = 163/665 (24%), Positives = 260/665 (39%), Gaps = 148/665 (22%)
Query: 605 VQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLE 664
+Q QEEE++ E ELQ R Q E +L+ L+ + L + ++ +Q L +
Sbjct: 852 LQVTRQEEEMQAK----EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 907
Query: 665 AEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGE----CQQLREEVEQCQ 720
A + ++ A + + M+A++ E+E Q + E QQ+ + EQ +
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 721 QLAEARHR----------ELRALESQCQQQTQLIEVLTAEKG--QQGVGPPTDNEARELA 768
+ AR + +++ LE + L+ E+ ++ + T N A E
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 769 AQLALSQ---------AQLEVH------------------QGEVQRLQAQVVDLQA---- 797
L++ ++LEV +G+ Q+ DLQA
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 798 ----------KMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKE----QNEALNRAHVQ 843
+++AAL D +Q + A +RE + + L+E + A N+A Q
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 844 -------------ELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLE 890
EL + QE RA Q+ +AL EE + +E + +
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207
Query: 891 HA----ELQEQLH-----RANTD---------TAELGIQVCALTVEKERVE---EALACA 929
HA EL EQL +AN D A+L ++ L K+ VE + L
Sbjct: 1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 930 VQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQL-AQAEQR 988
VQELQ R R L +V LQ E ES+ L A+ A L A L +Q +
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327
Query: 989 AQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEK 1048
+ LQE Q+LN ++L+ EE SL+ QL+E+ Q E +
Sbjct: 1328 QELLQEETRQKLNV------------STKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375
Query: 1049 LKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNK 1108
L +D +KL ++ + AL E +R QKE+E T Q+Y K
Sbjct: 1376 LNIQLSDSKKKLQDFASTV--------------EALEEGKKRFQKEIENLT---QQYEEK 1418
Query: 1109 LCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQK----L 1164
A D L +TK L++ L +L+ D D Q LE +Q+ L
Sbjct: 1419 ---------------AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1463
Query: 1165 SAEER 1169
AEE+
Sbjct: 1464 LAEEK 1468
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 163 bits (412), Expect = 1e-39
Identities = 221/992 (22%), Positives = 426/992 (42%), Gaps = 149/992 (15%)
Query: 224 LNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRT 283
L E L+ E+ E +++ VR ++ ++++ E + +G+QLQ ER+
Sbjct: 898 LLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK---- 953
Query: 284 AAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKE----EDYHTAL-- 337
++ + +L++Q E +A + + +L+ ++ E E +D + L
Sbjct: 954 ------KMAQQMLDLEEQLEEEEAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSK 1006
Query: 338 ------RRLESMLQPLAQELEATRDSLDKKNQH---LASFPGWLAMAQQKADTASDTKGR 388
R+ + LA+E E ++ KN+H ++ L ++ K +
Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1066
Query: 389 QEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERL 448
E SD +++ +L ++ L+ + K EE + A L +L E+ K +A + L
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEE---ELQAALARLDDEIAQKNNALKKIREL 1123
Query: 449 VKEMAPLQEELSGK--------------GQEADQLWRRLQELLAHTSSWEEELAELRREK 494
++ LQE+L + G+E + L L++ L T++ + ELR ++
Sbjct: 1124 EGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ----ELRAKR 1179
Query: 495 KQQQEE-KELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGML 553
+Q+ K+ L++E RS Q+Q + + AQ V +L EQ +Q + K +L + L
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQA---VEELTEQLEQFKRAKANLDKNKQTL 1236
Query: 554 ERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQ-EE 612
E+ EL V G+ + QE K ++ + +QE Q +K +G +
Sbjct: 1237 EKENADLAGELRVLGQ----------AKQEVEHKKKKLEAQVQELQ---SKCSDGERARA 1283
Query: 613 ELRQANRELEKELQNVVGRNQLLEGK----------LQALQADYQALQQRESA----IQG 658
EL +L+ E+++V G EGK L + D Q L Q E+ +
Sbjct: 1284 ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST 1343
Query: 659 SLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQ 718
L LE E+ S++ DQ++ + +AK+ ++ ++ L + + Q VE
Sbjct: 1344 KLRQLEEERNSLQ---DQLDEEM----EAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 719 CQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQ-----QGVGPPTDNEARELAAQLAL 773
++ + +E+ L Q +++ + L K + + DN+ R+L + L
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEK 1455
Query: 774 SQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQ 833
Q + + E + + ++ D + RA + ++K LS+A A L E ++L+
Sbjct: 1456 KQRKFDQLLAEEKNISSKYAD--ERDRAEAEAREKETKALSLARA-LEEALEAKEELERT 1512
Query: 834 NEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAE 893
N+ L +A +++L+ + G + E+ RAL+ ++ + K QLE E
Sbjct: 1513 NKML-KAEMEDLVSSKDDVG-------KNVHELEKSKRALETQMEEMK-----TQLE--E 1557
Query: 894 LQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAG 953
L+++L L + + AL + ER +LQ E +R L+RQ
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFER----------DLQARDEQNEEKRRQLQRQ--- 1604
Query: 954 LQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMD 1013
L + + L+++ K AA + L+ L E +A S + + + L+ +L A++ D
Sbjct: 1605 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR-KLQAQMKD 1663
Query: 1014 YQSRLKNA--------------GEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEK 1059
+Q L++A ++ KSL L + L AAE A ++ + ++ E+
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 1060 LSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELE-------KATTKIQEYYNKLCQE 1112
L+ + + Q R + A L E+LE Q +E KAT + ++ N+L E
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Query: 1113 VTNRERNDQKMLADLDDLNRTKKYLEERLIEL 1144
+ ++N+ L R K L +L E+
Sbjct: 1784 RSTAQKNESAR----QQLERQNKELRSKLHEM 1811
Score = 149 bits (377), Expect = 1e-35
Identities = 217/1000 (21%), Positives = 428/1000 (42%), Gaps = 161/1000 (16%)
Query: 212 QEMVSNFDLNSPLNNEALEGFDEMRLE----LDQLEVREKQLRERMQQLDRENQELRAAV 267
+E +S+ N E + +++ + + +LEVR K+ + Q+L++ ++L
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1071
Query: 268 SQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAA 327
S EQ+ L +AEL+ Q + +ELQ L L+ A
Sbjct: 1072 SDFHEQIAD--------------LQAQIAELKMQLAKKE------EELQAALARLDDEIA 1111
Query: 328 EKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKG 387
+K +R LE + L ++L++ R + +K + L + + + D+
Sbjct: 1112 QKNNALKK-IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1170
Query: 388 RQEPIPSDAAQEMQELGEKLQALERER-TKVEEVNRQQSAQLEQLVKELQLKEDARASLE 446
Q+ + + QE+ L + L R +V+E+ ++ + +E+L ++L+ + A+A+L+
Sbjct: 1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 447 R----LVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKE 502
+ L KE A L EL GQ ++ + ++L A + + ++ R + + ++
Sbjct: 1231 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1290
Query: 503 LLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGP 562
L+ EV S+T L E + ++++ V+ L Q +QD L Q+
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ----LQDTQELLQE---------ETRQ 1337
Query: 563 ELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQE------AQLDDTK--VQE-GSQEEE 613
+L V+ K L +SLQ+ + E ++ L+ QL D+K +Q+ S E
Sbjct: 1338 KLNVS-TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 614 LRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHL 673
L + + +KE++N+ Q E K A Y L++ ++ +Q L L + + R L
Sbjct: 1397 LEEGKKRFQKEIENLT---QQYEEKAAA----YDKLEKTKNRLQQELDDLVVDLDNQRQL 1449
Query: 674 GDQMEAS------LLAVRK---AKEAMKAQMAEKEAILQSKEG--------ECQQLREEV 716
+E LLA K +K A + AE EA + + E + +EE+
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 717 EQCQQLAEARHREL------------------RALESQCQQ-QTQLIEV----------- 746
E+ ++ +A +L RALE+Q ++ +TQL E+
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 747 ------LTAEKGQ-----QGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDL 795
+ A KGQ Q + + R+L QL + +LE + ++ +A
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE----DERKQRALAAAA 1625
Query: 796 QAKMRAALDDQD-KVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGA 854
+ K+ L D + + S + E +++ + L Q+K+ L A + A
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR-----DEIFA 1680
Query: 855 LQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCA 914
+E +A+ E +L LQE+L+ A+ + ++A LE EL E+L + + A
Sbjct: 1681 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN-------A 1733
Query: 915 LTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGS 974
L EK R+E +A +L++ E E + +V Q+ E L +L ++ A
Sbjct: 1734 LQDEKRRLEARIA----QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789
Query: 975 LPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEE 1034
+ QL E++ + L+ H+ +K + + I ++++ L Q+E+
Sbjct: 1790 NESARQQL---ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI-------AQLEEQVEQ 1839
Query: 1035 QGRQLQAAEEAV----EKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLER 1090
+ R+ QAA +++ +KLK + ++ + + + +G A + L+R
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE--------KGNARVKQLKR 1891
Query: 1091 TQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDL 1130
+E E+ + +I KL +E+ +++ M +++ L
Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1931
Score = 139 bits (351), Expect = 2e-32
Identities = 207/894 (23%), Positives = 391/894 (43%), Gaps = 147/894 (16%)
Query: 376 QQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKEL 435
Q K D TK RQ+ A E++EL +K L E+ ++E QL E
Sbjct: 862 QAKEDELQKTKERQQK----AENELKELEQKHSQLTEEKNLLQE----------QLQAET 907
Query: 436 QLKEDA----------RASLERLVKEMAPLQEELSGKGQEADQLWRRL-QELLAHTSSWE 484
+L +A + LE ++ EM EE +GQ+ +++ Q++L E
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 485 EELA---ELRREK-------KQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEE 534
EE A +L+ EK K+ ++E +++ + L+++ + LE +++ ++ ++++ EE
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 535 QKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRG 594
+ K L + K+ + LE L + + L + L+ E+
Sbjct: 1028 KAKNLTKLKNKHESMISELE-------VRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080
Query: 595 LQEAQLDDTKVQEGSQEEELRQANRELEKEL---QNVVGRNQLLEGKLQALQADYQALQQ 651
LQ AQ+ + K+Q +EEEL+ A L+ E+ N + + + LEG + LQ D
Sbjct: 1081 LQ-AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED------ 1133
Query: 652 RESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQ 711
+ A+ + R LG+++E A++ E A ++ + +E E
Sbjct: 1134 ----LDSERAARNKAEKQKRDLGEELE----ALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 712 LREEVEQCQQLAEARHRELRALESQC-QQQTQLIEVLTAEKGQQGVGPPT-DNEARELAA 769
L++ +++ + EA+ +E+R +Q ++ T+ +E K T + E +LA
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245
Query: 770 QL-ALSQAQLEVHQGEVQRLQAQVVDLQAK------MRAALDDQ-DKVQSQLSMAEAVLR 821
+L L QA+ EV + + ++L+AQV +LQ+K RA L+D+ K+Q+++ +L
Sbjct: 1246 ELRVLGQAKQEV-EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1304
Query: 822 EHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAK 881
E + +L + +L+ + +Q+ + + E + + + +Q EEE +LQ++L +
Sbjct: 1305 EAEGKAIKLAKDVASLS-SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 882 CSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVE----------EALACAVQ 931
+ + + + L QL + + V AL K+R + E A A
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423
Query: 932 ELQDAKEAASREREGL------ERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQA 985
+L+ K +E + L +RQ+ ++K+ ++L A + S + A+A
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 986 EQR---------AQSLQEA--AHQELNTLKFQLSAEIMDYQSRLKNAGE----------- 1023
E R A++L+EA A +EL L AE+ D S + G+
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1543
Query: 1024 ---ECKSLRGQLEEQGRQLQAAEEAVEKLKAT-QADMG--------------EKLSCTSN 1065
+ + ++ QLEE +LQA E+A +L+ QA G EK
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1603
Query: 1066 HLAECQAAMLRKDKE---GAALREDLERTQKELE-------KATTKIQEYYNKLCQEVTN 1115
L E + + + K+ AA ++ LE K+LE K + + KL ++ +
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663
Query: 1116 RERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEER 1169
+R + A D++ T K E++ L ++D ++ Q+ L+A ER
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSL---------EADLMQLQEDLAAAER 1708
Score = 112 bits (280), Expect = 3e-24
Identities = 136/627 (21%), Positives = 267/627 (42%), Gaps = 62/627 (9%)
Query: 238 ELDQLEVREK-QLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVA 296
EL Q E R+K + +++QL+ E L+ Q E+++ ++ R + N++L+
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQ---DQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Query: 297 ELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDY---HTALRRLESMLQPLAQELEA 353
+LQ +A + K Q ++ L EK Y RL+ L L +L+
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 354 TRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERE 413
R + + F LA + + +D + R E + + L L+
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1505
Query: 414 RTKVEEVNRQQSAQLEQLV-------KELQLKEDARASLERLVKEMAPLQEELSGKGQEA 466
+ ++E N+ A++E LV K + E ++ +LE ++EM EEL + Q
Sbjct: 1506 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1565
Query: 467 DQLWRRLQ-ELLAHTSSWEEELA--ELRREKKQQQEEKEL--LEQEVRSLTRQLQFLETQ 521
+ RL+ + A +E +L + + E+K++Q +++L E E+ +Q
Sbjct: 1566 EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1625
Query: 522 LAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSL 581
++ + DLE Q I+ ++ +Q+ L+ EL A +S
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA----------RASR 1675
Query: 582 QEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKE------LQNVVGRNQL- 634
E + +E ++ + + D ++QE E + +LEKE ++ GRN L
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1735
Query: 635 ------------LEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLL 682
LE +L+ Q + +A+ R L E A+ R + E++
Sbjct: 1736 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795
Query: 683 AVRKAKEAMKAQMAEKEAILQSK--------EGECQQLREEVEQCQQLAEARHRELRALE 734
+ + + +++++ E E ++SK E + QL E+VEQ EAR ++ A +
Sbjct: 1796 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ-----EAREKQA-ATK 1849
Query: 735 SQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVD 794
S Q+ +L E+L + ++ + +A + A++ + QLE + E QR+ A
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909
Query: 795 LQAKMRAALDDQDKVQSQLSMAEAVLR 821
LQ ++ A + + + +++ ++ LR
Sbjct: 1910 LQRELDEATESNEAMGREVNALKSKLR 1936
Score = 98.2 bits (243), Expect = 5e-20
Identities = 163/665 (24%), Positives = 260/665 (39%), Gaps = 148/665 (22%)
Query: 605 VQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLE 664
+Q QEEE++ E ELQ R Q E +L+ L+ + L + ++ +Q L +
Sbjct: 852 LQVTRQEEEMQAK----EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 907
Query: 665 AEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGE----CQQLREEVEQCQ 720
A + ++ A + + M+A++ E+E Q + E QQ+ + EQ +
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 721 QLAEARHR----------ELRALESQCQQQTQLIEVLTAEKG--QQGVGPPTDNEARELA 768
+ AR + +++ LE + L+ E+ ++ + T N A E
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 769 AQLALSQ---------AQLEVH------------------QGEVQRLQAQVVDLQA---- 797
L++ ++LEV +G+ Q+ DLQA
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 798 ----------KMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKE----QNEALNRAHVQ 843
+++AAL D +Q + A +RE + + L+E + A N+A Q
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 844 -------------ELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLE 890
EL + QE RA Q+ +AL EE + +E + +
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207
Query: 891 HA----ELQEQLH-----RANTD---------TAELGIQVCALTVEKERVE---EALACA 929
HA EL EQL +AN D A+L ++ L K+ VE + L
Sbjct: 1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 930 VQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQL-AQAEQR 988
VQELQ R R L +V LQ E ES+ L A+ A L A L +Q +
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327
Query: 989 AQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEK 1048
+ LQE Q+LN ++L+ EE SL+ QL+E+ Q E +
Sbjct: 1328 QELLQEETRQKLNV------------STKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375
Query: 1049 LKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNK 1108
L +D +KL ++ + AL E +R QKE+E T Q+Y K
Sbjct: 1376 LNIQLSDSKKKLQDFASTV--------------EALEEGKKRFQKEIENLT---QQYEEK 1418
Query: 1109 LCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQK----L 1164
A D L +TK L++ L +L+ D D Q LE +Q+ L
Sbjct: 1419 ---------------AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1463
Query: 1165 SAEER 1169
AEE+
Sbjct: 1464 LAEEK 1468
Score = 32.3 bits (72), Expect = 3.5
Identities = 28/156 (17%), Positives = 71/156 (45%), Gaps = 5/156 (3%)
Query: 210 QTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQ 269
+ +E N + S +A + +++ EL ++ QQL+R+N+ELR+ + +
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1810
Query: 270 QGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEK 329
++++ + T A ++ L +++++ QA ++K+ L+ + L ++
Sbjct: 1811 MEGAVKSKFK--STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868
Query: 330 E---EDYHTALRRLESMLQPLAQELEATRDSLDKKN 362
E Y + + ++ L ++LE + + N
Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 163 bits (412), Expect = 1e-39
Identities = 221/992 (22%), Positives = 426/992 (42%), Gaps = 149/992 (15%)
Query: 224 LNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRT 283
L E L+ E+ E +++ VR ++ ++++ E + +G+QLQ ER+
Sbjct: 891 LLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK---- 946
Query: 284 AAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKE----EDYHTAL-- 337
++ + +L++Q E +A + + +L+ ++ E E +D + L
Sbjct: 947 ------KMAQQMLDLEEQLEEEEAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSK 999
Query: 338 ------RRLESMLQPLAQELEATRDSLDKKNQH---LASFPGWLAMAQQKADTASDTKGR 388
R+ + LA+E E ++ KN+H ++ L ++ K +
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1059
Query: 389 QEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERL 448
E SD +++ +L ++ L+ + K EE + A L +L E+ K +A + L
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEE---ELQAALARLDDEIAQKNNALKKIREL 1116
Query: 449 VKEMAPLQEELSGK--------------GQEADQLWRRLQELLAHTSSWEEELAELRREK 494
++ LQE+L + G+E + L L++ L T++ + ELR ++
Sbjct: 1117 EGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ----ELRAKR 1172
Query: 495 KQQQEE-KELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGML 553
+Q+ K+ L++E RS Q+Q + + AQ V +L EQ +Q + K +L + L
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQA---VEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 554 ERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQ-EE 612
E+ EL V G+ + QE K ++ + +QE Q +K +G +
Sbjct: 1230 EKENADLAGELRVLGQ----------AKQEVEHKKKKLEAQVQELQ---SKCSDGERARA 1276
Query: 613 ELRQANRELEKELQNVVGRNQLLEGK----------LQALQADYQALQQRESA----IQG 658
EL +L+ E+++V G EGK L + D Q L Q E+ +
Sbjct: 1277 ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST 1336
Query: 659 SLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQ 718
L LE E+ S++ DQ++ + +AK+ ++ ++ L + + Q VE
Sbjct: 1337 KLRQLEEERNSLQ---DQLDEEM----EAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 719 CQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQ-----QGVGPPTDNEARELAAQLAL 773
++ + +E+ L Q +++ + L K + + DN+ R+L + L
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEK 1448
Query: 774 SQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQ 833
Q + + E + + ++ D + RA + ++K LS+A A L E ++L+
Sbjct: 1449 KQRKFDQLLAEEKNISSKYAD--ERDRAEAEAREKETKALSLARA-LEEALEAKEELERT 1505
Query: 834 NEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAE 893
N+ L +A +++L+ + G + E+ RAL+ ++ + K QLE E
Sbjct: 1506 NKML-KAEMEDLVSSKDDVG-------KNVHELEKSKRALETQMEEMK-----TQLE--E 1550
Query: 894 LQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAG 953
L+++L L + + AL + ER +LQ E +R L+RQ
Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFER----------DLQARDEQNEEKRRQLQRQ--- 1597
Query: 954 LQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMD 1013
L + + L+++ K AA + L+ L E +A S + + + L+ +L A++ D
Sbjct: 1598 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR-KLQAQMKD 1656
Query: 1014 YQSRLKNA--------------GEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEK 1059
+Q L++A ++ KSL L + L AAE A ++ + ++ E+
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 1060 LSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELE-------KATTKIQEYYNKLCQE 1112
L+ + + Q R + A L E+LE Q +E KAT + ++ N+L E
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Query: 1113 VTNRERNDQKMLADLDDLNRTKKYLEERLIEL 1144
+ ++N+ L R K L +L E+
Sbjct: 1777 RSTAQKNESAR----QQLERQNKELRSKLHEM 1804
Score = 149 bits (377), Expect = 1e-35
Identities = 217/1000 (21%), Positives = 428/1000 (42%), Gaps = 161/1000 (16%)
Query: 212 QEMVSNFDLNSPLNNEALEGFDEMRLE----LDQLEVREKQLRERMQQLDRENQELRAAV 267
+E +S+ N E + +++ + + +LEVR K+ + Q+L++ ++L
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1064
Query: 268 SQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAA 327
S EQ+ L +AEL+ Q + +ELQ L L+ A
Sbjct: 1065 SDFHEQIAD--------------LQAQIAELKMQLAKKE------EELQAALARLDDEIA 1104
Query: 328 EKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKG 387
+K +R LE + L ++L++ R + +K + L + + + D+
Sbjct: 1105 QKNNALKK-IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1163
Query: 388 RQEPIPSDAAQEMQELGEKLQALERER-TKVEEVNRQQSAQLEQLVKELQLKEDARASLE 446
Q+ + + QE+ L + L R +V+E+ ++ + +E+L ++L+ + A+A+L+
Sbjct: 1164 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 447 R----LVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKE 502
+ L KE A L EL GQ ++ + ++L A + + ++ R + + ++
Sbjct: 1224 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1283
Query: 503 LLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGP 562
L+ EV S+T L E + ++++ V+ L Q +QD L Q+
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ----LQDTQELLQE---------ETRQ 1330
Query: 563 ELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQE------AQLDDTK--VQE-GSQEEE 613
+L V+ K L +SLQ+ + E ++ L+ QL D+K +Q+ S E
Sbjct: 1331 KLNVS-TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 614 LRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHL 673
L + + +KE++N+ Q E K A Y L++ ++ +Q L L + + R L
Sbjct: 1390 LEEGKKRFQKEIENLT---QQYEEKAAA----YDKLEKTKNRLQQELDDLVVDLDNQRQL 1442
Query: 674 GDQMEAS------LLAVRK---AKEAMKAQMAEKEAILQSKEG--------ECQQLREEV 716
+E LLA K +K A + AE EA + + E + +EE+
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 717 EQCQQLAEARHREL------------------RALESQCQQ-QTQLIEV----------- 746
E+ ++ +A +L RALE+Q ++ +TQL E+
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 747 ------LTAEKGQ-----QGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDL 795
+ A KGQ Q + + R+L QL + +LE + ++ +A
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE----DERKQRALAAAA 1618
Query: 796 QAKMRAALDDQD-KVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGA 854
+ K+ L D + + S + E +++ + L Q+K+ L A + A
Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR-----DEIFA 1673
Query: 855 LQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCA 914
+E +A+ E +L LQE+L+ A+ + ++A LE EL E+L + + A
Sbjct: 1674 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN-------A 1726
Query: 915 LTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGS 974
L EK R+E +A +L++ E E + +V Q+ E L +L ++ A
Sbjct: 1727 LQDEKRRLEARIA----QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782
Query: 975 LPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEE 1034
+ QL E++ + L+ H+ +K + + I ++++ L Q+E+
Sbjct: 1783 NESARQQL---ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI-------AQLEEQVEQ 1832
Query: 1035 QGRQLQAAEEAV----EKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLER 1090
+ R+ QAA +++ +KLK + ++ + + + +G A + L+R
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE--------KGNARVKQLKR 1884
Query: 1091 TQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDL 1130
+E E+ + +I KL +E+ +++ M +++ L
Sbjct: 1885 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1924
Score = 139 bits (351), Expect = 2e-32
Identities = 207/894 (23%), Positives = 391/894 (43%), Gaps = 147/894 (16%)
Query: 376 QQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKEL 435
Q K D TK RQ+ A E++EL +K L E+ ++E QL E
Sbjct: 855 QAKEDELQKTKERQQK----AENELKELEQKHSQLTEEKNLLQE----------QLQAET 900
Query: 436 QLKEDA----------RASLERLVKEMAPLQEELSGKGQEADQLWRRL-QELLAHTSSWE 484
+L +A + LE ++ EM EE +GQ+ +++ Q++L E
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 485 EELA---ELRREK-------KQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEE 534
EE A +L+ EK K+ ++E +++ + L+++ + LE +++ ++ ++++ EE
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 535 QKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRG 594
+ K L + K+ + LE L + + L + L+ E+
Sbjct: 1021 KAKNLTKLKNKHESMISELE-------VRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073
Query: 595 LQEAQLDDTKVQEGSQEEELRQANRELEKEL---QNVVGRNQLLEGKLQALQADYQALQQ 651
LQ AQ+ + K+Q +EEEL+ A L+ E+ N + + + LEG + LQ D
Sbjct: 1074 LQ-AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED------ 1126
Query: 652 RESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQ 711
+ A+ + R LG+++E A++ E A ++ + +E E
Sbjct: 1127 ----LDSERAARNKAEKQKRDLGEELE----ALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 712 LREEVEQCQQLAEARHRELRALESQC-QQQTQLIEVLTAEKGQQGVGPPT-DNEARELAA 769
L++ +++ + EA+ +E+R +Q ++ T+ +E K T + E +LA
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238
Query: 770 QL-ALSQAQLEVHQGEVQRLQAQVVDLQAK------MRAALDDQ-DKVQSQLSMAEAVLR 821
+L L QA+ EV + + ++L+AQV +LQ+K RA L+D+ K+Q+++ +L
Sbjct: 1239 ELRVLGQAKQEV-EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1297
Query: 822 EHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAK 881
E + +L + +L+ + +Q+ + + E + + + +Q EEE +LQ++L +
Sbjct: 1298 EAEGKAIKLAKDVASLS-SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 882 CSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVE----------EALACAVQ 931
+ + + + L QL + + V AL K+R + E A A
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416
Query: 932 ELQDAKEAASREREGL------ERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQA 985
+L+ K +E + L +RQ+ ++K+ ++L A + S + A+A
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 986 EQR---------AQSLQEA--AHQELNTLKFQLSAEIMDYQSRLKNAGE----------- 1023
E R A++L+EA A +EL L AE+ D S + G+
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1536
Query: 1024 ---ECKSLRGQLEEQGRQLQAAEEAVEKLKAT-QADMG--------------EKLSCTSN 1065
+ + ++ QLEE +LQA E+A +L+ QA G EK
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1596
Query: 1066 HLAECQAAMLRKDKE---GAALREDLERTQKELE-------KATTKIQEYYNKLCQEVTN 1115
L E + + + K+ AA ++ LE K+LE K + + KL ++ +
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656
Query: 1116 RERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEER 1169
+R + A D++ T K E++ L ++D ++ Q+ L+A ER
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSL---------EADLMQLQEDLAAAER 1701
Score = 112 bits (280), Expect = 3e-24
Identities = 136/627 (21%), Positives = 267/627 (42%), Gaps = 62/627 (9%)
Query: 238 ELDQLEVREK-QLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVA 296
EL Q E R+K + +++QL+ E L+ Q E+++ ++ R + N++L+
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQ---DQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Query: 297 ELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDY---HTALRRLESMLQPLAQELEA 353
+LQ +A + K Q ++ L EK Y RL+ L L +L+
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 354 TRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERE 413
R + + F LA + + +D + R E + + L L+
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 414 RTKVEEVNRQQSAQLEQLV-------KELQLKEDARASLERLVKEMAPLQEELSGKGQEA 466
+ ++E N+ A++E LV K + E ++ +LE ++EM EEL + Q
Sbjct: 1499 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1558
Query: 467 DQLWRRLQ-ELLAHTSSWEEELA--ELRREKKQQQEEKEL--LEQEVRSLTRQLQFLETQ 521
+ RL+ + A +E +L + + E+K++Q +++L E E+ +Q
Sbjct: 1559 EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1618
Query: 522 LAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSL 581
++ + DLE Q I+ ++ +Q+ L+ EL A +S
Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA----------RASR 1668
Query: 582 QEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKE------LQNVVGRNQL- 634
E + +E ++ + + D ++QE E + +LEKE ++ GRN L
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1728
Query: 635 ------------LEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLL 682
LE +L+ Q + +A+ R L E A+ R + E++
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1788
Query: 683 AVRKAKEAMKAQMAEKEAILQSK--------EGECQQLREEVEQCQQLAEARHRELRALE 734
+ + + +++++ E E ++SK E + QL E+VEQ EAR ++ A +
Sbjct: 1789 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ-----EAREKQA-ATK 1842
Query: 735 SQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVD 794
S Q+ +L E+L + ++ + +A + A++ + QLE + E QR+ A
Sbjct: 1843 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902
Query: 795 LQAKMRAALDDQDKVQSQLSMAEAVLR 821
LQ ++ A + + + +++ ++ LR
Sbjct: 1903 LQRELDEATESNEAMGREVNALKSKLR 1929
Score = 98.2 bits (243), Expect = 5e-20
Identities = 163/665 (24%), Positives = 260/665 (39%), Gaps = 148/665 (22%)
Query: 605 VQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLE 664
+Q QEEE++ E ELQ R Q E +L+ L+ + L + ++ +Q L +
Sbjct: 845 LQVTRQEEEMQAK----EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 900
Query: 665 AEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGE----CQQLREEVEQCQ 720
A + ++ A + + M+A++ E+E Q + E QQ+ + EQ +
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 721 QLAEARHR----------ELRALESQCQQQTQLIEVLTAEKG--QQGVGPPTDNEARELA 768
+ AR + +++ LE + L+ E+ ++ + T N A E
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 769 AQLALSQ---------AQLEVH------------------QGEVQRLQAQVVDLQA---- 797
L++ ++LEV +G+ Q+ DLQA
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 798 ----------KMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKE----QNEALNRAHVQ 843
+++AAL D +Q + A +RE + + L+E + A N+A Q
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 844 -------------ELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLE 890
EL + QE RA Q+ +AL EE + +E + +
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200
Query: 891 HA----ELQEQLH-----RANTD---------TAELGIQVCALTVEKERVE---EALACA 929
HA EL EQL +AN D A+L ++ L K+ VE + L
Sbjct: 1201 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 930 VQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQL-AQAEQR 988
VQELQ R R L +V LQ E ES+ L A+ A L A L +Q +
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320
Query: 989 AQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEK 1048
+ LQE Q+LN ++L+ EE SL+ QL+E+ Q E +
Sbjct: 1321 QELLQEETRQKLNV------------STKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368
Query: 1049 LKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNK 1108
L +D +KL ++ + AL E +R QKE+E T Q+Y K
Sbjct: 1369 LNIQLSDSKKKLQDFASTV--------------EALEEGKKRFQKEIENLT---QQYEEK 1411
Query: 1109 LCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQK----L 1164
A D L +TK L++ L +L+ D D Q LE +Q+ L
Sbjct: 1412 ---------------AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1456
Query: 1165 SAEER 1169
AEE+
Sbjct: 1457 LAEEK 1461
Score = 32.3 bits (72), Expect = 3.5
Identities = 28/156 (17%), Positives = 71/156 (45%), Gaps = 5/156 (3%)
Query: 210 QTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQ 269
+ +E N + S +A + +++ EL ++ QQL+R+N+ELR+ + +
Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1803
Query: 270 QGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEK 329
++++ + T A ++ L +++++ QA ++K+ L+ + L ++
Sbjct: 1804 MEGAVKSKFK--STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1861
Query: 330 E---EDYHTALRRLESMLQPLAQELEATRDSLDKKN 362
E Y + + ++ L ++LE + + N
Sbjct: 1862 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 162 bits (411), Expect = 2e-39
Identities = 264/1086 (24%), Positives = 468/1086 (43%), Gaps = 102/1086 (9%)
Query: 273 QLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEED 332
QLQ + RGR A + L+ L+KQ +++ + ++E L+ GA + ED
Sbjct: 532 QLQVQDMRGRYEASQD-----LLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHED 586
Query: 333 YHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPI 392
++RL S + L++E SL Q L ++K A + RQ
Sbjct: 587 AQREVQRLRSANELLSREKSNLAHSLQVAQQQAEE----LRQEREKLQAAQEELRRQRDR 642
Query: 393 PSDAAQEMQELGEKLQA-LERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKE 451
+ ++ + G +++ LER ++E++ ++S ++LV+ + A + L E
Sbjct: 643 LEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAE 702
Query: 452 MAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSL 511
A + E L+ +L + +L A +S ++ L++L + ++K L + V L
Sbjct: 703 KAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQL 762
Query: 512 TRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKN 571
+ L+ + Q Q + E++++L ++ L Q+V + L G L VA +
Sbjct: 763 EEEKSALQGRQRQAEQEATVAREEQERL--EELRLEQEVAR-QGLEG----SLRVAEQAQ 815
Query: 572 EALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGR 631
EAL +L+ E+ LQE QL Q +E+EL QA RE +++++ +
Sbjct: 816 EALEQQLPTLRH-------ERSQLQE-QLAQLSRQLSGREQELEQARREAQRQVEAL--- 864
Query: 632 NQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAM 691
+ + +AL ++ L + A + +L E +R + +E SL V++ +
Sbjct: 865 -ERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQL 923
Query: 692 KAQM----AEKEAILQSKE---GECQQLREEVEQCQQLAEARHRELRA---LESQCQQQT 741
+A+ AE +A+L +KE GE LR+++ Q+ A +EL A ++++ + Q
Sbjct: 924 EARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASL-DKELMAQKLVQAEREAQA 982
Query: 742 QLIEVLTA-EKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEV-QRLQAQVVDLQAKM 799
L E A E+ Q + + REL A+ A Q+QL+ Q E+ RL+A+ +L ++
Sbjct: 983 SLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEI 1042
Query: 800 RAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEER 859
A ++D+ L +AE+ K LKE + + E +
Sbjct: 1043 AALQQERDE---GLLLAES----EKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQ 1095
Query: 860 ADEAQQREEELR----ALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQ--VC 913
+AQ R+E+ R AL EL + EEA HA+ ++ R +LG Q C
Sbjct: 1096 KRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQ---EVRRLQEQARDLGKQRDSC 1152
Query: 914 ALTVEKER-----VEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAA 968
E+ R +E+A +EL +A+ +EG E Q + + SL E K
Sbjct: 1153 LREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKER 1212
Query: 969 KAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRL-KNAGEECKS 1027
+A S L++ + +AE SL+ A N K Q A + + ++ + K AGE
Sbjct: 1213 EALRRSNEELRSAVKKAESERISLKLA-----NEDKEQKLALLEEARTAVGKEAGELRTG 1267
Query: 1028 L----RGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAA 1083
L R +LE + R+LQ ++ L + +G +L+ LA + A +E
Sbjct: 1268 LQEVERSRLEAR-RELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLG 1326
Query: 1084 LREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIE 1143
LR+ L + + LE ++Q KL ++ ++++L L++ T+K +
Sbjct: 1327 LRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARG 1386
Query: 1144 LLRDKDALWQKSDALEFQQKLSAEERWLGDTEANHC-LDCKREFSWMVRRHHCRICGRIF 1202
L +A +++A E +LSA E EA ++ +R R ++ G
Sbjct: 1387 LELKLEAA--RAEAAELGLRLSAAEGRAQGLEAELARVEVQR------RAAEAQLGGL-- 1436
Query: 1203 CYYCCNNYVLSKHGGKKERCCRACFQKLSEGPGSP--DSSGSGTSQGEPSPALSPASPGP 1260
L + G RA PGSP D+ G+ +G SP+ SPG
Sbjct: 1437 ------RSALRRGLGLG----RAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGS 1486
Query: 1261 QATGGQGANTDYRPPD---DAVFDIITDEELCQIQESGSSLPETPTETDSLDPNAAEQDT 1317
Q G T PD +AV + E L +++ + E T+T +L+ AE +
Sbjct: 1487 QPP-SPGPATSPASPDLDPEAVRGALR-EFLQELRSAQRERDELRTQTSALNRQLAEMEA 1544
Query: 1318 TSTSLT 1323
S T
Sbjct: 1545 ERDSAT 1550
Score = 154 bits (390), Expect = 5e-37
Identities = 223/963 (23%), Positives = 406/963 (42%), Gaps = 113/963 (11%)
Query: 202 SSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERM-------Q 254
S+L LQ Q+M ++ + L + + E LE + ++LR++ +
Sbjct: 526 SALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHE 585
Query: 255 QLDRENQELRAA-----------------VSQQGEQLQTERERGRTAAEDNVRLTCLVAE 297
RE Q LR+A QQ E+L+ ERE+ + A E+ R + E
Sbjct: 586 DAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEE 645
Query: 298 -----LQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELE 352
+Q V + + + ++L+ L+G A++ + AL R L E
Sbjct: 646 EQEDAVQDGARVRRELERSHRQLEQ-LEGKRSVLAKELVEVREALSRATLQRDMLQAEKA 704
Query: 353 ATRDSLDKKNQHLASFPGWLAMAQQKADTAS--DTKGRQEPIPSDAAQEMQELGEKLQAL 410
++L K L+M + +A+ AS D+ + + AQ+ +L + L
Sbjct: 705 EVAEALTKAEAGRVELE--LSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQL 762
Query: 411 ERERTKVEEVNRQQSAQL------EQLVKELQLKED-ARASLERLVK----EMAPLQEEL 459
E E++ ++ RQ + ++ ++EL+L+++ AR LE ++ L+++L
Sbjct: 763 EEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQL 822
Query: 460 SGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLE 519
E QL +L +L S E+EL + RRE ++Q E E +E +L ++ L
Sbjct: 823 PTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLA 882
Query: 520 TQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLER-LAGPPGPELPVAGEKNEALVPVN 578
QL + L E+ +L +K+ L + ++R LA + E L+
Sbjct: 883 VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKE 942
Query: 579 SSLQEAWGKPEEEQRGLQEAQLDD----TKVQEGSQEEE--LRQANRELEKELQNVVGRN 632
+ E G ++ ++A LD K+ + +E + LR+ E++LQ +
Sbjct: 943 TLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREK 1002
Query: 633 QLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAK-EAM 691
+ +L+A +A Q+ QRE + LA LEAE+ +++ + A+++ + E +
Sbjct: 1003 EAAWRELEAERAQLQSQLQREQ--EELLARLEAEK-------EELSEEIAALQQERDEGL 1053
Query: 692 KAQMAEKEAILQSKEGECQQLREEV----EQCQQLAEARHRELRALESQCQQQTQLIEVL 747
+EK+ L KE E L E++ ++ R+ R +S+ +Q + L
Sbjct: 1054 LLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNAL 1113
Query: 748 TAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQD 807
T +E R+L AQ + A H EV+RLQ Q DL + + L + +
Sbjct: 1114 T-------------SELRDLRAQREEAAA---AHAQEVRRLQEQARDLGKQRDSCLREAE 1157
Query: 808 KVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQRE 867
++++QL + E L ++L E L + +Q E G L+ + A++R
Sbjct: 1158 ELRTQLRLLEDA---RDGLRRELLEAQRKLRESQEGREVQRQE-AGELRRSLGEGAKER- 1212
Query: 868 EELRALQEELSQA--KCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEA 925
E LR EEL A K SE L+ A ++ A + A V KE E
Sbjct: 1213 EALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEAR-------TAVGKEAGE-- 1263
Query: 926 LACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKL-----------KAAKAAAGS 974
L +QE++ ++ A RE + L RQ+ L E L +L +A K +
Sbjct: 1264 LRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRE 1323
Query: 975 LPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEE 1034
GL+ +L + E + E QEL + +L + ++++R + + RG ++
Sbjct: 1324 TLGLRQRLLKGE----ASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQ 1379
Query: 1035 QGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKE 1094
Q + E +E +A A++G +LS +A + R + + A L +
Sbjct: 1380 QLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSA 1439
Query: 1095 LEK 1097
L +
Sbjct: 1440 LRR 1442
Score = 153 bits (386), Expect = 1e-36
Identities = 225/1019 (22%), Positives = 412/1019 (40%), Gaps = 152/1019 (14%)
Query: 234 EMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTC 293
++ +L +REK L ++ Q D + +L A V++ G
Sbjct: 366 QLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELG---------------------L 404
Query: 294 LVAELQKQ-WEVTQATQNTVKELQTCLQGLELG--AAEKEEDYHTALRRLESMLQPLAQE 350
V L+KQ E Q ++ ++L+ L+ L L AA + ED + L + Q + +
Sbjct: 405 AVKRLEKQNLEKDQVNKDLTEKLEA-LESLRLQEQAALETEDGEGLQQTLRDLAQAVLSD 463
Query: 351 LEA------TRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPI-PSDAAQEMQEL 403
E+ + + D N L G + + +S +GR PS A + L
Sbjct: 464 SESGVQLSGSERTADASNGSLRGLSGQRTPSPPRR--SSPGRGRSPRRGPSPACSDSSTL 521
Query: 404 GEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKG 463
AL + + +V+++ + A + L L+++LS
Sbjct: 522 ALIHSALHKRQLQVQDMRGRYEASQDLL---------------------GTLRKQLSDSE 560
Query: 464 QEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLA 523
E L +LQ L T + + +RE ++ + ELL +E +L LQ + Q
Sbjct: 561 SERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAE 620
Query: 524 QVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQE 583
++ Q L+ +++L + +D L ++ + EL + + E L S L +
Sbjct: 621 ELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAK 680
Query: 584 AWGKPEE--EQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQA 641
+ E + LQ L K + + ELE + + L+ L
Sbjct: 681 ELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSK 740
Query: 642 LQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAI 701
L A ++L Q + + +A LE E+++++ Q E R+ +E ++ E+E
Sbjct: 741 LSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVA 800
Query: 702 LQSKEG---------------------ECQQLREEVEQCQQLAEARHRELRALESQCQQQ 740
Q EG E QL+E++ Q + R +EL + Q+Q
Sbjct: 801 RQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQ 860
Query: 741 TQLIEVLTAEK---GQQGVG-----PPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQV 792
+ +E EK ++ G + E R L+ + + + E +G + +Q Q+
Sbjct: 861 VEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQL 920
Query: 793 VDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQL--KEQNEALNRAHVQELLQCSE 850
L+A+ R L+ + Q+ L E + E L QQ+ ++ +L++ + + L +E
Sbjct: 921 AQLEAR-REQLEAEG--QALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAE 977
Query: 851 RE--GALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAEL 908
RE +L+E+RA EE+L+ LQ E + + E + E A+LQ QL R +
Sbjct: 978 REAQASLREQRA----AHEEDLQRLQRE---KEAAWRELEAERAQLQSQLQREQEEL--- 1027
Query: 909 GIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAA 968
+ L EKE + E +A QE + A E+ ++ ++ + EK +L EKL
Sbjct: 1028 ---LARLEAEKEELSEEIAALQQERDEGLLLAESEK---QQALSLKESEKTALSEKLMGT 1081
Query: 969 KAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQL--------------SAEIMDY 1014
+ SL + ++ + ++ AQS QE +N L +L + E+
Sbjct: 1082 R---HSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRL 1138
Query: 1015 QSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKL--SCTSNHLAECQA 1072
Q + ++ G++ S + EE QL+ E+A + L+ + KL S + +A
Sbjct: 1139 QEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEA 1198
Query: 1073 AMLRKD-KEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLAD----- 1126
LR+ EGA RE L R+ +EL A K + ++ ++ N ++ + L +
Sbjct: 1199 GELRRSLGEGAKEREALRRSNEELRSAVKKAES--ERISLKLANEDKEQKLALLEEARTA 1256
Query: 1127 -----------LDDLNRTKKYLEERLIELLRDKDALWQKSDAL-----EFQQKLSAEER 1169
L ++ R++ L EL R L ++ L E Q +L+ ER
Sbjct: 1257 VGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGER 1315
Score = 147 bits (372), Expect = 6e-35
Identities = 228/1057 (21%), Positives = 430/1057 (40%), Gaps = 151/1057 (14%)
Query: 227 EALEGFDEMRLELDQLEVREKQLRERMQ-------QLDRENQELRAAVSQQGEQLQTERE 279
E E L+ D L+ + ++ E + +L+ +LRA + + L
Sbjct: 684 EVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSA 743
Query: 280 RGRTAAEDNVRLTCLVAELQKQWEVTQATQN-------TVKELQTCLQGLELGAAEKEED 332
+ A+D + L LVA+L+++ Q Q +E Q L+ L L +
Sbjct: 744 LNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQG 803
Query: 333 YHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPI 392
+LR E + L Q+L R + + LA L+ +Q+ + A RQ
Sbjct: 804 LEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEA 863
Query: 393 PSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEM 452
AA+E + L ++ L + E R S + +L E + E + ++R + ++
Sbjct: 864 LERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQL 923
Query: 453 APLQEELSGKGQE--------ADQLWRRLQELLA--HTSSWEEEL-------------AE 489
+E+L +GQ +L Q+++A +S ++EL A
Sbjct: 924 EARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQAS 983
Query: 490 LRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQ 549
LR ++ +E+ + L++E + R+L+ QL SQ + EE +L +K+ LS++
Sbjct: 984 LREQRAAHEEDLQRLQREKEAAWRELEAERAQLQ--SQLQREQEELLARLEAEKEELSEE 1041
Query: 550 VGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGS 609
+ L++ E++E L+ S Q+A E E+ L E +
Sbjct: 1042 IAALQQ-------------ERDEGLLLAESEKQQALSLKESEKTALSEKLM--------G 1080
Query: 610 QEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQ-QRESAIQGSLASLEAEQA 668
L + E+E++ ++ R + + AL ++ + L+ QRE A + Q
Sbjct: 1081 TRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQE 1140
Query: 669 SIRHLG----------DQMEASLLAVRKAKEAMKAQMAEKEAIL-QSKEGECQQLREEVE 717
R LG +++ L + A++ ++ ++ E + L +S+EG Q +E E
Sbjct: 1141 QARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGE 1200
Query: 718 QCQQLAEA---------RHRELRALESQCQQQTQLIEVLTAEKGQ-----QGVGPPTDNE 763
+ L E + ELR+ + + + +++ +K Q + E
Sbjct: 1201 LRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKE 1260
Query: 764 ARELAAQL-ALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLRE 822
A EL L + +++LE + E+Q L+ Q+ L ++ + ++Q +L++ E +E
Sbjct: 1261 AGELRTGLQEVERSRLEARR-ELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKE 1319
Query: 823 HKTLVQQLKE---QNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQ 879
+ L++ + EA QE LQ ++R+ LQE+ E + RE L EE
Sbjct: 1320 SRRETLGLRQRLLKGEASLEVMRQE-LQVAQRK--LQEQEG-EFRTRERRLLGSLEEAR- 1374
Query: 880 AKCSSEEAQLEHAE-LQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKE 938
+E+ QL+HA L+ +L A + AELG+++ A + +E LA
Sbjct: 1375 ---GTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELA----------- 1420
Query: 939 AASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQ 998
+R E Q+ GL+ +A A +PG A+ A AE + L +
Sbjct: 1421 RVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTL 1480
Query: 999 ELNTLKFQLS------------------AEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQ 1040
E + S + ++ L++A E LR Q RQL
Sbjct: 1481 ECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLA 1540
Query: 1041 AAE--------------EAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALRE 1086
E +AV + + + + +LS LA + ++ R ++E A +
Sbjct: 1541 EMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLD 1600
Query: 1087 D---LERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKM--LADLDDLNRTKKYLEERL 1141
LER+ + E QE +K+ T E + +++ + D + K L+ R
Sbjct: 1601 QVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRS 1660
Query: 1142 I--ELLRDKDALW-QKSDALEFQQKLSAEERWLGDTE 1175
+ EL R + L +++ A Q ++ + +R + D+E
Sbjct: 1661 LEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSE 1697
Score = 137 bits (346), Expect = 6e-32
Identities = 250/1098 (22%), Positives = 438/1098 (39%), Gaps = 188/1098 (17%)
Query: 234 EMRLELDQLEVREKQLRERMQQLDR------ENQELRAAVSQQGE---QLQTERERGRTA 284
+ R E D+L ++ + ER++Q R E QE R V Q E QLQ E+ R
Sbjct: 99 QSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRR- 157
Query: 285 AEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTA-LRRLESM 343
+L Q+Q ++ Q Q + + + LE E+ + LR E
Sbjct: 158 -----KLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEH- 211
Query: 344 LQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASD----------------TKG 387
+Q+LE+ L+++ Q AS AM +++ D A T+
Sbjct: 212 ----SQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRC 267
Query: 388 RQEPIPSDAAQEMQELG---------EKLQALERE----RTKVEEVNRQQSAQLEQLVKE 434
R+E +AA +E +L L R+ R V EV L QL E
Sbjct: 268 RKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGE 327
Query: 435 L------------------QLKED-ARASLERLVKEMAPLQEELSGKG-QEADQLWRRLQ 474
L +L E A A+LE+ A L+E+L K +E D +++Q
Sbjct: 328 LARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQ 387
Query: 475 ELL--AHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLET------------ 520
L A S+ EL + ++Q EK+ + ++ LT +L+ LE+
Sbjct: 388 SDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKD---LTEKLEALESLRLQEQAALETE 444
Query: 521 -------QLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAG-----PPGPELPVAG 568
L ++Q V E QL + G L L+G PP P G
Sbjct: 445 DGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRG 504
Query: 569 EK-----------NEALVPVNSSL-------QEAWGKPEEEQ--RGLQEAQLDDTKVQEG 608
+ L ++S+L Q+ G+ E Q G QL D++ +
Sbjct: 505 RSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERR 564
Query: 609 SQEEELR----------QANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQG 658
+ EE+L+ QA+ + ++E+Q + N+LL + L Q QQ+ ++
Sbjct: 565 ALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQ 624
Query: 659 SLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQ 718
L+A Q +R D++E + ++ ++ L+ EG+ L +E
Sbjct: 625 EREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKE--- 681
Query: 719 CQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQL 778
L E R RA + Q + EV A + + +L A+ A Q L
Sbjct: 682 ---LVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSL 738
Query: 779 EVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAE---AVLREHKTLVQQLKEQNE 835
+ L +DL + +++ +Q + AE V RE + +++L+ + E
Sbjct: 739 SKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQE 798
Query: 836 ALNRAHVQELLQCSEREGALQEE---RADEAQQREEELRALQEELSQAKCSSEEAQLEHA 892
+ L + + AL+++ E Q +E+L L +LS + E+A+ E
Sbjct: 799 VARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQ 858
Query: 893 ELQEQLHRANTDTAELGIQVCALTVE---KERVEEALACAVQELQDAKEAASREREGLER 949
E L RA + L + L V+ ER L+ L+ KEA ++R
Sbjct: 859 RQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQR 918
Query: 950 QVAGLQQEKESL----QEKLKAAKAAAGSLPGLQAQLAQAEQR--------AQSLQEAAH 997
Q+A L+ +E L Q L A + G L GL+ Q+ +++ AQ L +A
Sbjct: 919 QLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAER 978
Query: 998 QELNTLKFQLSAEIMDYQ--SRLKNAG-EECKSLRGQLEEQGRQLQAAEEAVEKLKATQA 1054
+ +L+ Q +A D Q R K A E ++ R QL+ Q ++ Q EE + +L+A +
Sbjct: 979 EAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQ--EELLARLEAEKE 1036
Query: 1055 DMGEKLSCTSNHL--------AECQAAMLRKDKEGAALRE--------------DLERTQ 1092
++ E+++ +E Q A+ K+ E AL E ++ER +
Sbjct: 1037 ELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQK 1096
Query: 1093 KELEKATTKIQEYYNKLCQEVTN-RERNDQKMLADLDDLNRTKKYLEERLIELLRDKDAL 1151
++ + + + N L E+ + R + ++ A ++ R L+E+ +L + +D+
Sbjct: 1097 RDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRR----LQEQARDLGKQRDSC 1152
Query: 1152 WQKSDALEFQQKLSAEER 1169
++++ L Q +L + R
Sbjct: 1153 LREAEELRTQLRLLEDAR 1170
Score = 134 bits (338), Expect = 5e-31
Identities = 261/1143 (22%), Positives = 444/1143 (38%), Gaps = 207/1143 (18%)
Query: 180 RRTLTTGSSAYLWKPPSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLEL 239
R L A L + + ++ L + TQE S L+ L + L +
Sbjct: 927 REQLEAEGQALLLAKETLTGELAGLRQQIIATQEKAS---LDKELMAQKLVQAEREA--- 980
Query: 240 DQLEVREKQL--RERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAE 297
Q +RE++ E +Q+L RE + + + QLQ++ +R E L L AE
Sbjct: 981 -QASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQR-----EQEELLARLEAE 1034
Query: 298 LQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDS 357
++ E A Q E GL L +EK++ AL ES L+++L TR S
Sbjct: 1035 KEELSEEIAALQQERDE------GLLLAESEKQQ----ALSLKESEKTALSEKLMGTRHS 1084
Query: 358 LDKKNQHLASFPGWLAMAQQKADTAS-----------------DTKGRQEPIPSDAAQEM 400
L + L M +QK D S D + ++E + AQE+
Sbjct: 1085 LATIS---------LEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEV 1135
Query: 401 QELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLER-LVKEMAPLQEEL 459
+ L E+ + L ++R + E+L +L+L EDAR L R L++ L+E
Sbjct: 1136 RRLQEQARDLGKQRDSCLR-------EAEELRTQLRLLEDARDGLRRELLEAQRKLRESQ 1188
Query: 460 SGKG---QEADQLWRRL--------------QELLAHTSSWEEELAELRREKKQQQEEKE 502
G+ QEA +L R L +EL + E E L+ + ++++
Sbjct: 1189 EGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLA 1248
Query: 503 LLEQ-------EVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLE- 554
LLE+ E L LQ +E + + + +L Q K L + L +++ L+
Sbjct: 1249 LLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQG 1308
Query: 555 RLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRG-------LQEAQLDDTKVQE 607
RLA GE+ E S +E G + +G QE Q+ K+QE
Sbjct: 1309 RLA---------LGERAE-----KESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQE 1354
Query: 608 GSQEEELRQANRELEKELQNVVG--RNQL-----LEGKLQALQADYQALQQRESAIQG-- 658
QE E R R L L+ G + QL LE KL+A +A+ L R SA +G
Sbjct: 1355 --QEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRA 1412
Query: 659 -----SLASLE----AEQASIRHLGDQMEASL---LAVRKAKEAMKAQMAEKEAILQSKE 706
LA +E A +A + L + L A A + A S E
Sbjct: 1413 QGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGE 1472
Query: 707 G-------EC----------------------QQLREEVEQCQQLAEARHRELRALESQC 737
G EC + +R + + Q + RE L +Q
Sbjct: 1473 GLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQT 1532
Query: 738 QQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVV---- 793
+ + + AE+ + AR+L +A S+ G + +QA++
Sbjct: 1533 SALNRQLAEMEAERDS------ATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEE 1586
Query: 794 ---DLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEAL--NRAHVQELLQC 848
+ + RA LD ++ L E+ LR + + ++K L ++ ++E+L
Sbjct: 1587 SVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDA 1646
Query: 849 SEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAEL 908
SE + E + R+L+ EL +++ + + + LQ+++ A+
Sbjct: 1647 SE----------SRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADS 1696
Query: 909 GIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAA 968
++ L + ER+ ALA + ++ E L + A L ++ KA
Sbjct: 1697 EVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKAL 1756
Query: 969 KAAAGSLPGLQAQLAQAEQRAQSLQEAAHQ--ELNTLKFQLSAEIMDYQSRLKNAGEECK 1026
A LQ +L A Q+L EA Q L L E+ D + + A + +
Sbjct: 1757 TACEHDRQVLQERLDAAR---QALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQ 1813
Query: 1027 SLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQA-------AMLRKDK 1079
LR L ++ AA V+KL+ + + E+L LA+ +A + LR +K
Sbjct: 1814 QLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEK 1873
Query: 1080 EGAALREDLERTQKELEKA---TTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKY 1136
+ ALR L++ ++E ++ T ++ +L + +T E +L + R +
Sbjct: 1874 DRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAE-------LELAEAQRQIQQ 1926
Query: 1137 LEERLIELLRDKDALWQKSDALEFQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHCR 1196
LE +++ L + + DA + Q +L E L +A +R R H R
Sbjct: 1927 LEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQA----QTERTLEARERAHRQR 1982
Query: 1197 ICG 1199
+ G
Sbjct: 1983 VRG 1985
Score = 130 bits (326), Expect = 1e-29
Identities = 210/943 (22%), Positives = 389/943 (41%), Gaps = 108/943 (11%)
Query: 234 EMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTC 293
++R + ++ Q R+Q+ R+ + R + ++ E+L+T+ R A D +R
Sbjct: 1119 DLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQL-RLLEDARDGLRREL 1177
Query: 294 LVAE--LQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQEL 351
L A+ L++ E + + EL+ + L GA E+E ALRR L+ ++
Sbjct: 1178 LEAQRKLRESQEGREVQRQEAGELR---RSLGEGAKERE-----ALRRSNEELRSAVKKA 1229
Query: 352 EATRDSL----DKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKL 407
E+ R SL + K Q LA ++A E +A +E+QEL ++
Sbjct: 1230 ESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQM 1289
Query: 408 QALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASL---ERLVKEMAPLQEELSGKGQ 464
+ L+ E T++ + +L + E KE R +L +RL+K A L+ Q
Sbjct: 1290 KMLDSENTRLGRELAELQGRLA--LGERAEKESRRETLGLRQRLLKGEASLEV----MRQ 1343
Query: 465 EADQLWRRLQELLAHTSSWEEELA----ELRREKKQQQEEKELLEQEVRSLTRQLQFLET 520
E R+LQE + E L E R +KQQ + LE ++ + + L
Sbjct: 1344 ELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGL 1403
Query: 521 QLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERL---------AGPPGPELPVAGEKN 571
+L+ LE + ++ + Q+G L A P P PV G
Sbjct: 1404 RLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPR-PVPGS-- 1460
Query: 572 EALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGR 631
P + E G+ L+ GSQ A +L R
Sbjct: 1461 ----PARDAPAEGSGEGLNSPSTLE--------CSPGSQPPSPGPATSPASPDLDPEAVR 1508
Query: 632 NQLLE--GKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKE 689
L E +L++ Q + L+ + SA+ LA +EAE+ S Q++ ++ +A+
Sbjct: 1509 GALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARR 1568
Query: 690 AMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTA 749
++ +++ +A L +E ++ E R L+A ES+ + + I + A
Sbjct: 1569 SVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKA 1628
Query: 750 EKGQQGVGPPTDNEARELAAQLALSQAQ---LEVH----QGEVQRLQAQVVDLQAKMRAA 802
+ + + + R L L S+++ LE+ +GE+QR + + D +A+ +A
Sbjct: 1629 NETK------LEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQAL 1682
Query: 803 LDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADE 862
D D +Q Q++ +E + V++L N AL + E EGAL+++
Sbjct: 1683 QDRVDSLQRQVADSEVKAGTLQLTVERL---NGALAKVE--------ESEGALRDK---- 1727
Query: 863 AQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERV 922
+R L E L+Q+ S + ++ LQ+ L D L ++ A
Sbjct: 1728 -------VRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEA 1780
Query: 923 EEALACAVQELQDAK-EAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQ 981
+ + +++Q + E A E + +E + LQQ +E L+++ + AA ++ LQ +
Sbjct: 1781 RKQSSSLGEQVQTLRGEVADLELQRVEAE-GQLQQLREVLRQRQEGEAAALNTVQKLQDE 1839
Query: 982 LAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQA 1041
++R SLQ A Q L AE + + ++ +LR L++ R+
Sbjct: 1840 RRLLQERLGSLQRALAQ--------LEAEKREVERSALRLEKDRVALRRTLDKVEREKLR 1891
Query: 1042 AEEAVEKLKATQADMGEKLSCTSNHLAECQ---------AAMLRKDKEGAALREDLERTQ 1092
+ E +L A + + L+ LAE Q +L + A L D ++ Q
Sbjct: 1892 SHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQ 1951
Query: 1093 KELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKK 1135
EL++ +++ + + + RER ++ + L++ T K
Sbjct: 1952 LELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLK 1994
Score = 113 bits (283), Expect = 1e-24
Identities = 180/835 (21%), Positives = 337/835 (40%), Gaps = 133/835 (15%)
Query: 261 QELRAAVSQQGEQLQT---ERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQT 317
+E R AV ++ +L+T E ER R A ++ EL++Q ++ + +
Sbjct: 1251 EEARTAVGKEAGELRTGLQEVERSRLEARRELQ------ELRRQMKMLDSENTRLGRELA 1304
Query: 318 CLQG-LELGA-AEKEEDYHTA-----LRRLESMLQPLAQELEATRDSLD--------KKN 362
LQG L LG AEKE T L + E+ L+ + QEL+ + L ++
Sbjct: 1305 ELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRER 1364
Query: 363 QHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQ---EMQELGEKLQALERERTKVEE 419
+ L S +Q+ D A + + E ++AA+ + + Q LE E +VE
Sbjct: 1365 RLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEV 1424
Query: 420 VNRQQSAQLEQLVKELQLKEDARASLERLVKEM--APLQE---ELSGKGQEADQLWRRLQ 474
R AQL L L+ + + + +P ++ E SG+G +
Sbjct: 1425 QRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSP 1484
Query: 475 ELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEE 534
+ A + + + QE+RS R+ L TQ + +++ ++++E
Sbjct: 1485 GSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEA 1544
Query: 535 QKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRG 594
++ ++ LQ+A + EE +R
Sbjct: 1545 ER-----------------------------------DSATSRARQLQKAVAESEEARRS 1569
Query: 595 LQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRES 654
+ + +L + + QEE +R++ RE L V LE LQA +++ +A Q++ S
Sbjct: 1570 V-DGRLSGVQAELALQEESVRRSERERRATLDQVA----TLERSLQATESELRASQEKIS 1624
Query: 655 AIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLRE 714
++ + LE ++ ++ + D E+ + + + +++ ++ L +E + Q L++
Sbjct: 1625 KMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQD 1684
Query: 715 EVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALS 774
V+ Q+ + L+ ++ + + +G ++ R L LA S
Sbjct: 1685 RVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGA------LRDKVRGLTEALAQS 1738
Query: 775 QAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQN 834
A L + + + LQ + A D+ +Q +L A L E + L EQ
Sbjct: 1739 SASLN-------STRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQV 1791
Query: 835 EALNRAHVQEL-LQCSEREGALQEERA-------------DEAQQREEELRALQEELSQA 880
+ L R V +L LQ E EG LQ+ R + Q+ ++E R LQE L
Sbjct: 1792 QTL-RGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSL 1850
Query: 881 KCSSEEAQLEHAELQEQLHRANTDTAELGIQV--------------CALTVEKERVEEAL 926
+ + + + E E++ R D L + L+ EK R++ L
Sbjct: 1851 QRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTL 1910
Query: 927 ACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAE 986
A EL +A+ R+ + LE QV L+Q Q ++ A Q Q + +
Sbjct: 1911 TGAELELAEAQ----RQIQQLEAQVVVLEQSHSPAQLEVDA-----------QQQQLELQ 1955
Query: 987 QRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQA 1041
Q + L+ A Q TL+ + A ++ R++ E+ +L+GQL+++ R+ A
Sbjct: 1956 QEVERLRSAQAQTERTLEARERA----HRQRVRGLEEQVSTLKGQLQQELRRSSA 2006
Score = 99.0 bits (245), Expect = 3e-20
Identities = 194/812 (23%), Positives = 332/812 (40%), Gaps = 78/812 (9%)
Query: 390 EPIPSDAAQEMQELGEKLQALERERTKVEEVNRQ-QSAQLEQLVKELQLKEDARASLERL 448
+ + S + + LG + A + + T + + R+ + L Q + L ASL L
Sbjct: 20 QTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPESPVLLPATEMASLLSL 79
Query: 449 VKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELA------ELRREKKQQQEEKE 502
+E LQ+ELS R+++LLA + + +ELA R E+ + E E
Sbjct: 80 QEENQLLQQELS-----------RVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGE 128
Query: 503 LLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGP 562
L QE R L RQ L QL + + +++L ++ +Q +++RL G
Sbjct: 129 LETQEPRGLVRQSVELRRQLQE------EQASYRRKLQAYQEGQQRQAQLVQRLQGKILQ 182
Query: 563 ELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELE 622
E + L+ + L++ + E + L+ A + +E + L Q N L
Sbjct: 183 YKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI--RLEEEQQRSASLAQVNAMLR 240
Query: 623 KELQNVVGRNQLLEGKLQALQADY----QALQQRESAIQGSLASLEA----EQASIRHLG 674
++L NQ L ++ + D+ + L+ RE+A + S A E + + L
Sbjct: 241 EQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLW 300
Query: 675 DQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALE 734
Q+ V + K + + + L Q+ + +LAE+R ALE
Sbjct: 301 RQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAE--AALE 358
Query: 735 SQCQQQTQLIEVL----TAEKGQQGVGPPTDNEARELAA---QLALSQAQLE-------- 779
Q Q QL E L EK +D + +L+A +L L+ +LE
Sbjct: 359 KQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQ 418
Query: 780 VHQGEVQRLQAQVVDLQAKMRAALDDQD---KVQSQLSMAEAVLREHKTLVQQLKEQNEA 836
V++ ++L+A + L+ + +AAL+ +D Q+ +A+AVL + ++ VQ + A
Sbjct: 419 VNKDLTEKLEA-LESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTA 477
Query: 837 LNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQE 896
A L S + R+ + R + + + L +LQ
Sbjct: 478 --DASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQV 535
Query: 897 QLHRANTDTAE--LGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGL 954
Q R + ++ LG L+ + E AL +Q L+D + A + E +R+V L
Sbjct: 536 QDMRGRYEASQDLLGTLRKQLS-DSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRL 594
Query: 955 QQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDY 1014
+ E L + A SL Q Q + Q + LQ AA +EL + +L E D
Sbjct: 595 RSANELLS---REKSNLAHSLQVAQQQAEELRQEREKLQ-AAQEELRRQRDRLEEEQED- 649
Query: 1015 QSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAM 1074
A ++ +R +LE RQL+ E L ++ E LS A Q M
Sbjct: 650 ------AVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALS-----RATLQRDM 698
Query: 1075 LRKDK-EGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRT 1133
L+ +K E A E + ELE + TK++ L ++ ++ + D DLNR
Sbjct: 699 LQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRL 758
Query: 1134 KKYLEERLIELL-RDKDALWQKSDALEFQQKL 1164
LEE L R + A + + A E Q++L
Sbjct: 759 VAQLEEEKSALQGRQRQAEQEATVAREEQERL 790
Score = 54.3 bits (129), Expect = 9e-07
Identities = 108/433 (24%), Positives = 168/433 (38%), Gaps = 96/433 (22%)
Query: 200 SMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLE--LDQLEVREKQLRERMQQLD 257
S+ + S +QE +S N LEG D+ RL+ LD E R +L + + L+
Sbjct: 1608 SLQATESELRASQEKISKMKANET----KLEG-DKRRLKEVLDASESRTVKLELQRRSLE 1662
Query: 258 RENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQT 317
E Q R +S + Q Q ++R V LQ+Q ++ T LQ
Sbjct: 1663 GELQRSRLGLSDREAQAQALQDR--------------VDSLQRQVADSEVKAGT---LQL 1705
Query: 318 CLQGLELGAAEKEEDYHTALR-RLESMLQPLAQE---LEATRDSLDKKNQHLASFPGWLA 373
++ L GA K E+ ALR ++ + + LAQ L +TRD + L +
Sbjct: 1706 TVERLN-GALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQ 1764
Query: 374 MAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVE-------EVNRQQS- 425
+ Q++ D A S +++Q L ++ LE +R + E EV RQ+
Sbjct: 1765 VLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQE 1824
Query: 426 ------------------------------AQLEQLVKE-----LQLKEDA---RASLE- 446
AQLE +E L+L++D R +L+
Sbjct: 1825 GEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDK 1884
Query: 447 -------------RLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRRE 493
RL E L L+G E + R++Q+L A E+ + + E
Sbjct: 1885 VEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLE 1944
Query: 494 KKQQQEEKELLEQEVRSLTRQLQ---FLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQV 550
QQ++ EL ++ R + Q Q LE + Q V LEEQ L K L Q++
Sbjct: 1945 VDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTL---KGQLQQEL 2001
Query: 551 GMLERLAGPP-GP 562
PP GP
Sbjct: 2002 RRSSAPFSPPSGP 2014
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 162 bits (411), Expect = 2e-39
Identities = 240/1006 (23%), Positives = 425/1006 (42%), Gaps = 114/1006 (11%)
Query: 241 QLEVREKQLRERMQQLDRENQELRAAVSQQGE------QLQTERERGRTAAE-------- 286
+L+ + E+ QL+R QE AV+Q E Q Q E ER R AE
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1636
Query: 287 ---DNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESM 343
+ +RL E+ +Q + QA KE + + G AE++ L E
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKE-EAEREARRRGKAEEQAVRQRELAEQE-- 1693
Query: 344 LQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQEL 403
L+ Q E T Q L +Q+ + R + + A Q+ QEL
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 404 GEKLQALERE-------RTKVEEVNRQQSAQLEQLVKE-----LQLKEDA---RASLERL 448
+L + E + + EE +R S + +Q ++ +L E+A RA E
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1813
Query: 449 VKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEV 508
++ +E+ + + EA+++ L E LA E L+ E + +EKE + +
Sbjct: 1814 KRQRQLAEEDAARQRAEAERV---LAEKLAAIG----EATRLKTEAEIALKEKEAENERL 1866
Query: 509 RSLTRQLQFLETQLA-QVSQHVSDLEEQKKQLIQDKD-HLSQQVGMLE---RLAGPPGPE 563
R L F +L Q +QH +D+EE+ QL + D L +Q G++E R E
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926
Query: 564 LPVAGEKNEALVPVNSSLQEAWGK----PEEEQRGLQEAQLDDTKVQEGSQEEELRQANR 619
+ E + L+ G+ E+ R ++A+L+ + ++ + EEE R+ R
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 1984
Query: 620 ELEKELQNVVG--------RNQLLEGKLQALQADYQ-ALQQRESAIQGSLASLE-AEQAS 669
E E+ +Q + R LE +++ L+A + A + RE A Q S L+ A++A+
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 670 IRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRE 729
+ L + +A AV++ ++ ++ + +++++L GE + R E+ ++ RE
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2103
Query: 730 LRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQ 789
Q ++ +L + +AE+ Q AQ A + + E Q +R Q
Sbjct: 2104 AAQSRRQVEEAERLKQ--SAEEQAQA----------RAQAQAAAEKLRKEAEQEAARRAQ 2151
Query: 790 AQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCS 849
A+ L+ K A + ++ AE LR+ + Q+L L Q+ L
Sbjct: 2152 AEQAALRQKQAADAE----MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Query: 850 EREGALQEERADEAQQR---EEEL---RALQEELSQAKCSSE------------EAQLEH 891
E + L+ E + A+QR EEEL R EELS+ K E Q
Sbjct: 2208 ELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266
Query: 892 AELQEQLHRANTDTAELGIQVCALTVEKERVEEALA---CAVQELQDAKEAASREREGLE 948
E E++ + + A L + ++ EE LA +++ K A +E L+
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2326
Query: 949 RQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLS 1008
+ LQQ+KE QE+ + + + A+ Q QR + E++ +L
Sbjct: 2327 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLA 1068
+ + A E+ + R Q EE G +L E A ++ K T E S+H A
Sbjct: 2387 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDA 2445
Query: 1069 E-CQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADL 1127
E + A+ ++E L+++ + Q + E+ T QE +L QE + Q L++
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---QLLQET---QALQQSFLSEK 2499
Query: 1128 DDLNRTKKYLEE---RLIELLRDKDALWQK-SDALEFQQKLSAEER 1169
D L + ++++E+ +L +L +D+ A Q+ + + QQ+ +ER
Sbjct: 2500 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER 2545
Score = 157 bits (397), Expect = 7e-38
Identities = 245/1020 (24%), Positives = 438/1020 (42%), Gaps = 150/1020 (14%)
Query: 195 PSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQ 254
P ++ +SL Q + FD A E + ++ + +V ++ RER+
Sbjct: 1123 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1182
Query: 255 QLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEV--------TQ 306
QL Q + A + +L+ + R E L + + +++ E +Q
Sbjct: 1183 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 307 ATQNTVKELQTCLQGLELGAAEKEE-------------DYHTALRRLESMLQPLAQ---- 349
A + +++ Q L+ +E + EE DY L ++ L+P+A
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1302
Query: 350 -ELEATRDSLDKKNQHLAS-FPGWLAMAQQKADTASDTKGRQEP----IPSDAAQEMQEL 403
++++ +S+ ++ L + + + Q S+T R E A+E + L
Sbjct: 1303 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362
Query: 404 GEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKG 463
E ALE++R ++ E + Q AQ E+ KELQ +R+ +E+ +E
Sbjct: 1363 AEVEAALEKQR-QLAEAHAQAKAQAEREAKELQ---------QRMQEEVVRREEAAVDAQ 1412
Query: 464 QEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQ-- 521
Q+ + LQ+L S E E+ R+ + + + +E+E+R + QL+ E Q
Sbjct: 1413 QQKRSIQEELQQL---RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469
Query: 522 -----LAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLER--------LAGPPGPELPVAG 568
L + + E QK+Q ++ + L +QV + LA E A
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1529
Query: 569 EKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNV 628
EK AL +L+E + EE +R L++A+++ + + + E R A EL+ + +
Sbjct: 1530 EKQRAL----QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Query: 629 VGRNQLLEGKLQALQADYQALQQ-RESAIQGSLASLEAEQASIRHLGDQMEASLLAVR-K 686
+ LE ++LQ ++ A+ Q RE A + + EAE+A ++ E L + K
Sbjct: 1586 AEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQAEAERAR-----EEAERELERWQLK 1637
Query: 687 AKEAMKAQMAEKEAILQSK--EGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLI 744
A EA++ ++ +E Q + E ++ +EE E+ EAR R E Q +Q +L
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER-----EARRR--GKAEEQAVRQRELA 1690
Query: 745 EVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQR--LQAQVVDLQAKMRAA 802
E ++ Q G + LAA+ L + + E QGE QR L+ ++ LQ + AA
Sbjct: 1691 EQELEKQRQLAEG----TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1746
Query: 803 LDDQDKVQSQLSMAEAVL-----------REHKTLVQQLKEQNEALNRAHVQELLQCSER 851
+ +++++L+ A + E ++ ++ K++ EA +EL + + R
Sbjct: 1747 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-EAGRFRELAEEAAR 1805
Query: 852 EGALQEE--------RADEAQQREEELRALQEEL------SQAKCSSEEAQLEHAELQEQ 897
AL EE D A+QR E R L E+L ++ K +E A E E+
Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1865
Query: 898 LHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREG----LERQ--- 950
L R D A ++ R+EE A Q D +E ++ R+ LERQ
Sbjct: 1866 LRRLAEDEA----------FQRRRLEEQ---AAQHKADIEERLAQLRKASDSELERQKGL 1912
Query: 951 VAGLQQEKESLQEKLKAAKA----AAGSLPGLQAQLAQAEQRAQ-SLQEAAHQELNTLK- 1004
V +++ ++E++ A KA AA L+ +L + A+ +L+ EL +
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 1005 FQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKA------TQADMGE 1058
QL+AE + R + A E + EE RQ +AA E VE+LKA + E
Sbjct: 1973 RQLAAE---EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2029
Query: 1059 KLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRER 1118
+ S LA+ +AA R E A +++ ++EL++ + Q ++L E R
Sbjct: 2030 QESARQLQLAQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088
Score = 142 bits (357), Expect = 3e-33
Identities = 212/904 (23%), Positives = 386/904 (42%), Gaps = 127/904 (14%)
Query: 241 QLEVREKQLRERMQQL----DRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVA 296
+LE ++R M+ L R +E R+ + ++L+ E R R AE+ RL L
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811
Query: 297 ELQKQWEVTQ---ATQNTVKELQTCLQGLELGAAEK-EEDYHTALRRLES---MLQPLAQ 349
E ++Q ++ + A Q E + +G A + + + AL+ E+ L+ LA+
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1871
Query: 350 ELEATRDSLDKKN-QHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQ 408
+ R L+++ QH A LA ++ +D+ + RQ+ + D ++ +++ E++
Sbjct: 1872 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE---RQKGLVEDTLRQRRQVEEEIL 1928
Query: 409 ALERERTKVEEVNRQQSAQLEQLVKELQ--LKEDARASLERLVKEMAPLQEELSGKGQEA 466
AL+ K + +L ++ + L+ +A LE + +EE + +EA
Sbjct: 1929 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREA 1986
Query: 467 DQLWRRLQELLAHTSSWEEE----LAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQL 522
++ R+Q+ LA + L E+ R K + +E + L E+ + RQLQ +
Sbjct: 1987 EE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 523 -----AQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPV 577
A+ H +++++++L Q L Q+ +L++L G A E EA V
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQT---LQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2100
Query: 578 NSSLQEAWGKPEEEQRGLQ----------EAQLDDTKVQEGSQEEELRQA---------- 617
++ + EE +R Q +AQ K+++ +++E R+A
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2160
Query: 618 ---NRELEKE---LQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIR 671
+ E+EK + + + +E +L L+ + +++ + L L+AE
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2220
Query: 672 HLGDQMEASLLAVRKAKEAMKAQMAEKEA-----ILQSKEGECQQLREEVEQCQQLAEAR 726
Q+E L +VR E + A EA IL+ K+ + L+EE E+ +Q+AE
Sbjct: 2221 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2280
Query: 727 HR---------ELRAL-ESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQA 776
R LR L E QQ L E + EK Q EA L A+ L Q
Sbjct: 2281 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ------AVQEATRLKAEAELLQQ 2334
Query: 777 QLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEA 836
Q E+ Q + +RLQ +DK Q +AE +TL + + Q E
Sbjct: 2335 QKELAQEQARRLQ----------------EDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Query: 837 LNRAHVQELLQCSEREGALQEERADEAQQR-EEELRALQEELSQAKCSSEEAQLEHAELQ 895
A E L+ E + + RA+E QR ++ + E+L + + +++E L+
Sbjct: 2379 SAEA---ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2435
Query: 896 EQLHRANTDTAELGIQVCALTVEKERVEEALACA---------------VQELQDAKEAA 940
Q +++ D L + L EKE++++ +QE Q +++
Sbjct: 2436 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2495
Query: 941 SREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL-PGLQAQLAQAEQRAQ----SLQEA 995
E++ L ++ ++QEK L++ + A A L Q Q Q EQ Q S++EA
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555
Query: 996 AHQ----ELNTLKFQLSAEIMDYQSRLKN--AGEECKSLRGQLEEQGRQLQAAEEAVEKL 1049
+ E + Q + ++ Q R + EE + LR QL+ Q +AA E++
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615
Query: 1050 KATQ 1053
A+Q
Sbjct: 2616 TASQ 2619
Score = 129 bits (324), Expect = 2e-29
Identities = 207/880 (23%), Positives = 381/880 (43%), Gaps = 139/880 (15%)
Query: 385 TKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQ---LVKELQLKEDA 441
T G+ E + S +A +++L + + + R EEV R QL++ + L E
Sbjct: 1070 TLGKLEQVRSLSAIYLEKL-KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1128
Query: 442 RASLERLVKEMAP-------LQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREK 494
+ASL++L + L++EL G + ++L +R E W E +A+L
Sbjct: 1129 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1188
Query: 495 KQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQL----IQDKDHLSQQV 550
+ + ++ ++E+ L RQL++ + + D +++Q+ + D + +Q+
Sbjct: 1189 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1248
Query: 551 GMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDT------- 603
+ L E+ GEK E A K E Q +AQL+
Sbjct: 1249 RQEQALL----EEIERHGEKVEECQRFAKQYINAI-KDYELQLVTYKAQLEPVASPAKKP 1303
Query: 604 KVQEGSQE-----EELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQG 658
KVQ GS+ +LR EL + + + L+ ++ + + +Q+ + +
Sbjct: 1304 KVQSGSESVIQEYVDLRTHYSELTTLTSQYI---KFISETLRRMEEEERLAEQQRAEERE 1360
Query: 659 SLASLEAEQASIRHLGD-QMEASLLAVRKAKE---AMKAQMAEKEAILQSKEGECQQLRE 714
LA +EA R L + +A A R+AKE M+ ++ +E + + + ++E
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420
Query: 715 EVEQCQQLAE----ARHRELRALES---QCQQQTQLIEV-LTAEKGQQGVGPPTDNEARE 766
E++Q +Q +E A+ R+ A E + +++ +++ + L A + Q+G + E +
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG---GAEGELQA 1477
Query: 767 LAAQLALSQAQLEVHQGEVQRLQAQVVD-LQAKMRAALDDQDKVQSQLSMAEAVLREHKT 825
L A+ ++AQ Q E +RL+ QV D Q K +A ++ +V+++ A RE +
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA----REKQR 1533
Query: 826 LVQQLKE-------------QNEALNRAHVQELLQCSER--EGALQEERADEAQQREEEL 870
+Q L+E Q E VQ L+ ++R E LQ +RA A++ +
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593
Query: 871 RALQEE---LSQAKCSSEEAQLEHAELQEQLHRANTDTAELGI---QVCALTVEKERVEE 924
R+LQEE ++Q + +E + AE + A + + + L ++ E V +
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1653
Query: 925 ALACAVQELQDAKEAASRE--REGLERQVAGLQQE--KESLQEKLKAAK-------AAAG 973
+ A E + KE A RE R G + A Q+E ++ L+++ + A+ AA
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 974 SLPGLQAQLAQAEQRAQSLQE----------AAHQELNTLKFQLSAEIMDYQ-------- 1015
L L+A+ Q EQ+ Q L+E AA Q+ L+ +L+ + +
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Query: 1016 --------------------SRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKA-TQA 1054
R + EE LR EE RQ Q AEE + +A +
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1833
Query: 1055 DMGEKLSC---TSNHLAECQAAMLRKDKEGAALR-----EDLERTQKELEKATTK--IQE 1104
+ EKL+ + E + A+ K+ E LR E +R + E + A K I+E
Sbjct: 1834 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1893
Query: 1105 YYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIEL 1144
+L ++ ++ E QK L ++D R ++ +EE ++ L
Sbjct: 1894 RLAQL-RKASDSELERQKGL--VEDTLRQRRQVEEEILAL 1930
Score = 113 bits (282), Expect = 2e-24
Identities = 182/798 (22%), Positives = 328/798 (41%), Gaps = 88/798 (11%)
Query: 229 LEGFDEMRLELDQLEVREKQLRERMQQ---LDRENQELRAAVSQQGEQLQTERERGRTAA 285
LE + +L ++ E R ++ ER+Q+ + E R A ++ E+L+ + E R
Sbjct: 1967 LEAARQRQLAAEE-ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2025
Query: 286 EDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQ 345
E AE + ++ A + K LQ + +KE++ L++ +S+L
Sbjct: 2026 ER--------AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2077
Query: 346 PLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGE 405
L E EA R + ++ + A ++++ + A K +A+E +
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK--------QSAEEQAQARA 2129
Query: 406 KLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQE 465
+ QA + K E + AQ EQ L+ K+ A A +E+ K + + QE
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQAA--LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187
Query: 466 ADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQV 525
L +L+E + +EEL L+ E + ++ +E+E+ S+ Q++ L A++
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2247
Query: 526 SQHVSDLEEQKKQLIQDKDH----LSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSL 581
E + +++DKD+ L ++ ++++A L VA ++ + L
Sbjct: 2248 EA------ENRALILRDKDNTQRFLQEEAEKMKQVA-EEAARLSVAAQEA-------ARL 2293
Query: 582 QEAWGKPEEEQRGLQEAQLDDTK--VQEGSQ---EEELRQANRELEKELQNVVGRN---- 632
++ + +QR L E L + VQE ++ E EL Q +EL +E + +
Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353
Query: 633 -QLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAM 691
Q L + Q Q +A +QR+ + L+ A + + E RK E +
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413
Query: 692 KAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ---CQQQTQLIEVLT 748
++ E Q K Q L + +Q AE + LE + QQ+ +L+++ +
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2473
Query: 749 AE----KGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALD 804
E + +Q + + L+ + +L Q + + Q E +L+ D AK + +
Sbjct: 2474 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ-EKAKLEQLFQDEVAKAQQLRE 2532
Query: 805 DQDKVQSQL---------SMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
+Q + Q Q+ SM EA R+H E E + R QE LQ E++
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQH--------EAEEGVRRK--QEELQQLEQQRRQ 2582
Query: 856 QEER-ADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHR--------ANTDTA 906
QEE A+E Q+ E+L+ L+E+ A SEE + L A
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2642
Query: 907 ELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQ-VAGLQQEKESLQE-K 964
E V +R++EA + +ELQ + + E R+ V Q + S+
Sbjct: 2643 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2702
Query: 965 LKAAKAAAGSLPGLQAQL 982
LKA LQ QL
Sbjct: 2703 LKATNEKLSVYAALQRQL 2720
Score = 104 bits (260), Expect = 6e-22
Identities = 248/1151 (21%), Positives = 429/1151 (37%), Gaps = 256/1151 (22%)
Query: 230 EGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNV 289
E + + EL+ E + K+L+ +L RE+ R V LQT+ +
Sbjct: 656 ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSW-------ML 708
Query: 290 RLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEE-DYHTALRRLESMLQPLA 348
+L C + K+ + V+E + LQ L+ K D + RLE +LQ
Sbjct: 709 QLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQ--- 765
Query: 349 QELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQ 408
D+ D+K Q L + G L+ ++A K P A M+ L
Sbjct: 766 -------DAQDEKEQ-LNEYKGHLSGLAKRAKAVVQLK------PRHPAHPMRGRLPLLA 811
Query: 409 ALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMA-----PLQE------ 457
+ ++ +V V++ QL + K + + E V + P QE
Sbjct: 812 VCDYKQVEV-TVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVT 870
Query: 458 ELSGKGQEADQLWRRLQELLAHTSSWEE-----------ELAELRREKKQQQ-------- 498
L + Q LW +L + +W+ LA R K ++Q
Sbjct: 871 RLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE 930
Query: 499 ------------------EEKELLEQEVRSLTRQLQFLETQLAQVSQH-------VSDLE 533
E++ + E+E S + Q L L Q +Q +S+L+
Sbjct: 931 LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 990
Query: 534 EQKKQLIQDKDHLSQQVGM----------LERLAGPPGPELPVAG--------------- 568
+ + QL + ++ + +R+A + V G
Sbjct: 991 DIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKV 1050
Query: 569 ----EKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTK----VQEGSQ-EEELRQANR 619
E + A + S L+ GK E+ R L L+ K V G+Q EE+ +A+
Sbjct: 1051 LALPEPSPAAPTLRSELELTLGK-LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE 1109
Query: 620 ELEKELQNVVGRNQLLE---GKLQALQADYQA---------------------LQQRE-- 653
E KE Q V LE L+ L+A +A LQQR
Sbjct: 1110 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1169
Query: 654 ----------------SAIQGSLASLEAEQASIRHLG----------DQMEASLLAVRKA 687
Q LA + Q + LG D + A L R+
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1229
Query: 688 KE-----------AMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ 736
+E A++ Q+ +++A+L+ E ++ E+VE+CQ+ A+ ++ E
Sbjct: 1230 QEQIQAMPLADSQAVREQLRQEQALLE----EIERHGEKVEECQRFAKQYINAIKDYE-- 1283
Query: 737 CQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQ-AQLEVHQGEVQRLQAQVVDL 795
++++T + + V P + ++ + + L H E+ L +Q +
Sbjct: 1284 -------LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1336
Query: 796 QAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
++ +++++++ Q E RE V+ E+ L AH Q Q L
Sbjct: 1337 ISETLRRMEEEERLAEQQRAEE---RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1393
Query: 856 QEERADEAQQREE-------ELRALQEELSQAKCSSE---EAQLEHAELQEQLH-RANTD 904
Q+ +E +REE + R++QEEL Q + SSE +A+ AE E+ R +
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453
Query: 905 TAELGIQVCALTVEKERVE---EALACAVQELQDAKEAASREREGLERQVAGLQQEKESL 961
+ +Q+ A ++ E +AL +E + K A E E L RQV Q K
Sbjct: 1454 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513
Query: 962 QEKL--------KAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKF-----QLS 1008
+ +L +AA+ +L L+ QAE+ + L++A + ++ Q S
Sbjct: 1514 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1573
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQLEE------------------QGRQLQAAEEAVEKLK 1050
AE + QS+ + E+ L L+E Q +A EEA +L+
Sbjct: 1574 AE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Query: 1051 ATQADMGEKLS--------CTSNHLAECQAAMLRKDKEGAALR----EDLERTQKEL-EK 1097
Q E L LA+ +A +++ E A R E+ Q+EL E+
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 1098 ATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDA 1157
K ++ Q+ E+ ++ A+ + + ++ LEE L L R+ A QK
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752
Query: 1158 LEFQ-QKLSAE 1167
LE + K+ AE
Sbjct: 1753 LEAELAKVRAE 1763
Score = 49.3 bits (116), Expect = 3e-05
Identities = 73/345 (21%), Positives = 147/345 (42%), Gaps = 24/345 (6%)
Query: 865 QREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRAN----TDTAELG---IQVCALTV 917
+RE++LR+ E L + + Q+E +EQL++A+ +D L + A V
Sbjct: 379 EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEV 438
Query: 918 EK--ERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL 975
E+ ++ + + ++Q K+ + E + R+V L + +++ + A +
Sbjct: 439 ERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAA 498
Query: 976 PGLQAQLAQAEQRAQSLQEAAHQELNTLKF--QLSAEIMDYQSRLKNA--GEECKSLRGQ 1031
P Q A+ QS+Q E +TL++ L A + + Q R+ A G + S+ Q
Sbjct: 499 PATQV----AQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ 554
Query: 1032 LEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERT 1091
L Q+ EE K++ ++D G+ T +C + R D + A L +
Sbjct: 555 LGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDC---LGRLDLQYAKLLNSSKAR 611
Query: 1092 QKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDAL 1151
+ LE + + +L + E+ ++++ D D N +E L+R+ +
Sbjct: 612 LRSLESLHSFVAAATKEL---MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 668
Query: 1152 WQKSDALE-FQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHC 1195
+K L+ +L E+ T + + ++SWM++ C
Sbjct: 669 EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCC 713
Score = 42.7 bits (99), Expect = 0.003
Identities = 56/242 (23%), Positives = 92/242 (38%), Gaps = 27/242 (11%)
Query: 197 RSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQL 256
+ + + L S +QT + L L D + +E + +L + Q
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2523
Query: 257 DRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQ 316
+ Q+LR +Q +Q++ ER+R LVA +++ + V+ Q
Sbjct: 2524 VAKAQQLREEQQRQQQQMEQERQR-------------LVASMEEARRRQHEAEEGVRRKQ 2570
Query: 317 TCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQ 376
LQ LE ++EE +RL LQ L E R +L + AS
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQLLE---EQHRAALAHSEEVTASQVAATKTLP 2627
Query: 377 QKADTASDTKGRQEPIPS-------DAAQEMQELG----EKLQALERERTKVEEVNRQQS 425
D EP S +AQ +QE G E+LQ L + T V+E+ R++
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2687
Query: 426 AQ 427
+
Sbjct: 2688 VR 2689
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 162 bits (411), Expect = 2e-39
Identities = 240/1006 (23%), Positives = 425/1006 (42%), Gaps = 114/1006 (11%)
Query: 241 QLEVREKQLRERMQQLDRENQELRAAVSQQGE------QLQTERERGRTAAE-------- 286
+L+ + E+ QL+R QE AV+Q E Q Q E ER R AE
Sbjct: 1581 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1640
Query: 287 ---DNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESM 343
+ +RL E+ +Q + QA KE + + G AE++ L E
Sbjct: 1641 KANEALRLRLQAEEVAQQKSLAQAEAEKQKE-EAEREARRRGKAEEQAVRQRELAEQE-- 1697
Query: 344 LQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQEL 403
L+ Q E T Q L +Q+ + R + + A Q+ QEL
Sbjct: 1698 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757
Query: 404 GEKLQALERE-------RTKVEEVNRQQSAQLEQLVKE-----LQLKEDA---RASLERL 448
+L + E + + EE +R S + +Q ++ +L E+A RA E
Sbjct: 1758 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1817
Query: 449 VKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEV 508
++ +E+ + + EA+++ L E LA E L+ E + +EKE + +
Sbjct: 1818 KRQRQLAEEDAARQRAEAERV---LAEKLAAIG----EATRLKTEAEIALKEKEAENERL 1870
Query: 509 RSLTRQLQFLETQLA-QVSQHVSDLEEQKKQLIQDKD-HLSQQVGMLE---RLAGPPGPE 563
R L F +L Q +QH +D+EE+ QL + D L +Q G++E R E
Sbjct: 1871 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1930
Query: 564 LPVAGEKNEALVPVNSSLQEAWGK----PEEEQRGLQEAQLDDTKVQEGSQEEELRQANR 619
+ E + L+ G+ E+ R ++A+L+ + ++ + EEE R+ R
Sbjct: 1931 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 1988
Query: 620 ELEKELQNVVG--------RNQLLEGKLQALQADYQ-ALQQRESAIQGSLASLE-AEQAS 669
E E+ +Q + R LE +++ L+A + A + RE A Q S L+ A++A+
Sbjct: 1989 EAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2047
Query: 670 IRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRE 729
+ L + +A AV++ ++ ++ + +++++L GE + R E+ ++ RE
Sbjct: 2048 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2107
Query: 730 LRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQ 789
Q ++ +L + +AE+ Q AQ A + + E Q +R Q
Sbjct: 2108 AAQSRRQVEEAERLKQ--SAEEQAQA----------RAQAQAAAEKLRKEAEQEAARRAQ 2155
Query: 790 AQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCS 849
A+ L+ K A + ++ AE LR+ + Q+L L Q+ L
Sbjct: 2156 AEQAALRQKQAADAE----MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2211
Query: 850 EREGALQEERADEAQQR---EEEL---RALQEELSQAKCSSE------------EAQLEH 891
E + L+ E + A+QR EEEL R EELS+ K E Q
Sbjct: 2212 ELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2270
Query: 892 AELQEQLHRANTDTAELGIQVCALTVEKERVEEALA---CAVQELQDAKEAASREREGLE 948
E E++ + + A L + ++ EE LA +++ K A +E L+
Sbjct: 2271 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2330
Query: 949 RQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLS 1008
+ LQQ+KE QE+ + + + A+ Q QR + E++ +L
Sbjct: 2331 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2390
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLA 1068
+ + A E+ + R Q EE G +L E A ++ K T E S+H A
Sbjct: 2391 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDA 2449
Query: 1069 E-CQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADL 1127
E + A+ ++E L+++ + Q + E+ T QE +L QE + Q L++
Sbjct: 2450 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---QLLQET---QALQQSFLSEK 2503
Query: 1128 DDLNRTKKYLEE---RLIELLRDKDALWQK-SDALEFQQKLSAEER 1169
D L + ++++E+ +L +L +D+ A Q+ + + QQ+ +ER
Sbjct: 2504 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER 2549
Score = 157 bits (397), Expect = 7e-38
Identities = 245/1020 (24%), Positives = 438/1020 (42%), Gaps = 150/1020 (14%)
Query: 195 PSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQ 254
P ++ +SL Q + FD A E + ++ + +V ++ RER+
Sbjct: 1127 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1186
Query: 255 QLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEV--------TQ 306
QL Q + A + +L+ + R E L + + +++ E +Q
Sbjct: 1187 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1246
Query: 307 ATQNTVKELQTCLQGLELGAAEKEE-------------DYHTALRRLESMLQPLAQ---- 349
A + +++ Q L+ +E + EE DY L ++ L+P+A
Sbjct: 1247 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1306
Query: 350 -ELEATRDSLDKKNQHLAS-FPGWLAMAQQKADTASDTKGRQEP----IPSDAAQEMQEL 403
++++ +S+ ++ L + + + Q S+T R E A+E + L
Sbjct: 1307 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1366
Query: 404 GEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKG 463
E ALE++R ++ E + Q AQ E+ KELQ +R+ +E+ +E
Sbjct: 1367 AEVEAALEKQR-QLAEAHAQAKAQAEREAKELQ---------QRMQEEVVRREEAAVDAQ 1416
Query: 464 QEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQ-- 521
Q+ + LQ+L S E E+ R+ + + + +E+E+R + QL+ E Q
Sbjct: 1417 QQKRSIQEELQQL---RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1473
Query: 522 -----LAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLER--------LAGPPGPELPVAG 568
L + + E QK+Q ++ + L +QV + LA E A
Sbjct: 1474 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1533
Query: 569 EKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNV 628
EK AL +L+E + EE +R L++A+++ + + + E R A EL+ + +
Sbjct: 1534 EKQRAL----QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1589
Query: 629 VGRNQLLEGKLQALQADYQALQQ-RESAIQGSLASLEAEQASIRHLGDQMEASLLAVR-K 686
+ LE ++LQ ++ A+ Q RE A + + EAE+A ++ E L + K
Sbjct: 1590 AEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQAEAERAR-----EEAERELERWQLK 1641
Query: 687 AKEAMKAQMAEKEAILQSK--EGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLI 744
A EA++ ++ +E Q + E ++ +EE E+ EAR R E Q +Q +L
Sbjct: 1642 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER-----EARRR--GKAEEQAVRQRELA 1694
Query: 745 EVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQR--LQAQVVDLQAKMRAA 802
E ++ Q G + LAA+ L + + E QGE QR L+ ++ LQ + AA
Sbjct: 1695 EQELEKQRQLAEG----TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1750
Query: 803 LDDQDKVQSQLSMAEAVL-----------REHKTLVQQLKEQNEALNRAHVQELLQCSER 851
+ +++++L+ A + E ++ ++ K++ EA +EL + + R
Sbjct: 1751 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-EAGRFRELAEEAAR 1809
Query: 852 EGALQEE--------RADEAQQREEELRALQEEL------SQAKCSSEEAQLEHAELQEQ 897
AL EE D A+QR E R L E+L ++ K +E A E E+
Sbjct: 1810 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1869
Query: 898 LHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREG----LERQ--- 950
L R D A ++ R+EE A Q D +E ++ R+ LERQ
Sbjct: 1870 LRRLAEDEA----------FQRRRLEEQ---AAQHKADIEERLAQLRKASDSELERQKGL 1916
Query: 951 VAGLQQEKESLQEKLKAAKA----AAGSLPGLQAQLAQAEQRAQ-SLQEAAHQELNTLK- 1004
V +++ ++E++ A KA AA L+ +L + A+ +L+ EL +
Sbjct: 1917 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1976
Query: 1005 FQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKA------TQADMGE 1058
QL+AE + R + A E + EE RQ +AA E VE+LKA + E
Sbjct: 1977 RQLAAE---EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2033
Query: 1059 KLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRER 1118
+ S LA+ +AA R E A +++ ++EL++ + Q ++L E R
Sbjct: 2034 QESARQLQLAQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2092
Score = 142 bits (357), Expect = 3e-33
Identities = 212/904 (23%), Positives = 386/904 (42%), Gaps = 127/904 (14%)
Query: 241 QLEVREKQLRERMQQL----DRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVA 296
+LE ++R M+ L R +E R+ + ++L+ E R R AE+ RL L
Sbjct: 1756 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1815
Query: 297 ELQKQWEVTQ---ATQNTVKELQTCLQGLELGAAEK-EEDYHTALRRLES---MLQPLAQ 349
E ++Q ++ + A Q E + +G A + + + AL+ E+ L+ LA+
Sbjct: 1816 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1875
Query: 350 ELEATRDSLDKKN-QHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQ 408
+ R L+++ QH A LA ++ +D+ + RQ+ + D ++ +++ E++
Sbjct: 1876 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE---RQKGLVEDTLRQRRQVEEEIL 1932
Query: 409 ALERERTKVEEVNRQQSAQLEQLVKELQ--LKEDARASLERLVKEMAPLQEELSGKGQEA 466
AL+ K + +L ++ + L+ +A LE + +EE + +EA
Sbjct: 1933 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREA 1990
Query: 467 DQLWRRLQELLAHTSSWEEE----LAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQL 522
++ R+Q+ LA + L E+ R K + +E + L E+ + RQLQ +
Sbjct: 1991 EE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2047
Query: 523 -----AQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPV 577
A+ H +++++++L Q L Q+ +L++L G A E EA V
Sbjct: 2048 QKRLQAEEKAHAFAVQQKEQELQQT---LQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2104
Query: 578 NSSLQEAWGKPEEEQRGLQ----------EAQLDDTKVQEGSQEEELRQA---------- 617
++ + EE +R Q +AQ K+++ +++E R+A
Sbjct: 2105 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2164
Query: 618 ---NRELEKE---LQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIR 671
+ E+EK + + + +E +L L+ + +++ + L L+AE
Sbjct: 2165 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2224
Query: 672 HLGDQMEASLLAVRKAKEAMKAQMAEKEA-----ILQSKEGECQQLREEVEQCQQLAEAR 726
Q+E L +VR E + A EA IL+ K+ + L+EE E+ +Q+AE
Sbjct: 2225 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2284
Query: 727 HR---------ELRAL-ESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQA 776
R LR L E QQ L E + EK Q EA L A+ L Q
Sbjct: 2285 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ------AVQEATRLKAEAELLQQ 2338
Query: 777 QLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEA 836
Q E+ Q + +RLQ +DK Q +AE +TL + + Q E
Sbjct: 2339 QKELAQEQARRLQ----------------EDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2382
Query: 837 LNRAHVQELLQCSEREGALQEERADEAQQR-EEELRALQEELSQAKCSSEEAQLEHAELQ 895
A E L+ E + + RA+E QR ++ + E+L + + +++E L+
Sbjct: 2383 SAEA---ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2439
Query: 896 EQLHRANTDTAELGIQVCALTVEKERVEEALACA---------------VQELQDAKEAA 940
Q +++ D L + L EKE++++ +QE Q +++
Sbjct: 2440 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2499
Query: 941 SREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL-PGLQAQLAQAEQRAQ----SLQEA 995
E++ L ++ ++QEK L++ + A A L Q Q Q EQ Q S++EA
Sbjct: 2500 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2559
Query: 996 AHQ----ELNTLKFQLSAEIMDYQSRLKN--AGEECKSLRGQLEEQGRQLQAAEEAVEKL 1049
+ E + Q + ++ Q R + EE + LR QL+ Q +AA E++
Sbjct: 2560 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2619
Query: 1050 KATQ 1053
A+Q
Sbjct: 2620 TASQ 2623
Score = 129 bits (324), Expect = 2e-29
Identities = 207/880 (23%), Positives = 381/880 (43%), Gaps = 139/880 (15%)
Query: 385 TKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQ---LVKELQLKEDA 441
T G+ E + S +A +++L + + + R EEV R QL++ + L E
Sbjct: 1074 TLGKLEQVRSLSAIYLEKL-KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1132
Query: 442 RASLERLVKEMAP-------LQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREK 494
+ASL++L + L++EL G + ++L +R E W E +A+L
Sbjct: 1133 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1192
Query: 495 KQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQL----IQDKDHLSQQV 550
+ + ++ ++E+ L RQL++ + + D +++Q+ + D + +Q+
Sbjct: 1193 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1252
Query: 551 GMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDT------- 603
+ L E+ GEK E A K E Q +AQL+
Sbjct: 1253 RQEQALL----EEIERHGEKVEECQRFAKQYINAI-KDYELQLVTYKAQLEPVASPAKKP 1307
Query: 604 KVQEGSQE-----EELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQG 658
KVQ GS+ +LR EL + + + L+ ++ + + +Q+ + +
Sbjct: 1308 KVQSGSESVIQEYVDLRTHYSELTTLTSQYI---KFISETLRRMEEEERLAEQQRAEERE 1364
Query: 659 SLASLEAEQASIRHLGD-QMEASLLAVRKAKE---AMKAQMAEKEAILQSKEGECQQLRE 714
LA +EA R L + +A A R+AKE M+ ++ +E + + + ++E
Sbjct: 1365 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1424
Query: 715 EVEQCQQLAE----ARHRELRALES---QCQQQTQLIEV-LTAEKGQQGVGPPTDNEARE 766
E++Q +Q +E A+ R+ A E + +++ +++ + L A + Q+G + E +
Sbjct: 1425 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG---GAEGELQA 1481
Query: 767 LAAQLALSQAQLEVHQGEVQRLQAQVVD-LQAKMRAALDDQDKVQSQLSMAEAVLREHKT 825
L A+ ++AQ Q E +RL+ QV D Q K +A ++ +V+++ A RE +
Sbjct: 1482 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA----REKQR 1537
Query: 826 LVQQLKE-------------QNEALNRAHVQELLQCSER--EGALQEERADEAQQREEEL 870
+Q L+E Q E VQ L+ ++R E LQ +RA A++ +
Sbjct: 1538 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1597
Query: 871 RALQEE---LSQAKCSSEEAQLEHAELQEQLHRANTDTAELGI---QVCALTVEKERVEE 924
R+LQEE ++Q + +E + AE + A + + + L ++ E V +
Sbjct: 1598 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1657
Query: 925 ALACAVQELQDAKEAASRE--REGLERQVAGLQQE--KESLQEKLKAAK-------AAAG 973
+ A E + KE A RE R G + A Q+E ++ L+++ + A+ AA
Sbjct: 1658 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1717
Query: 974 SLPGLQAQLAQAEQRAQSLQE----------AAHQELNTLKFQLSAEIMDYQ-------- 1015
L L+A+ Q EQ+ Q L+E AA Q+ L+ +L+ + +
Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1777
Query: 1016 --------------------SRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKA-TQA 1054
R + EE LR EE RQ Q AEE + +A +
Sbjct: 1778 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1837
Query: 1055 DMGEKLSC---TSNHLAECQAAMLRKDKEGAALR-----EDLERTQKELEKATTK--IQE 1104
+ EKL+ + E + A+ K+ E LR E +R + E + A K I+E
Sbjct: 1838 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1897
Query: 1105 YYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIEL 1144
+L ++ ++ E QK L ++D R ++ +EE ++ L
Sbjct: 1898 RLAQL-RKASDSELERQKGL--VEDTLRQRRQVEEEILAL 1934
Score = 113 bits (282), Expect = 2e-24
Identities = 182/798 (22%), Positives = 328/798 (41%), Gaps = 88/798 (11%)
Query: 229 LEGFDEMRLELDQLEVREKQLRERMQQ---LDRENQELRAAVSQQGEQLQTERERGRTAA 285
LE + +L ++ E R ++ ER+Q+ + E R A ++ E+L+ + E R
Sbjct: 1971 LEAARQRQLAAEE-ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2029
Query: 286 EDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQ 345
E AE + ++ A + K LQ + +KE++ L++ +S+L
Sbjct: 2030 ER--------AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2081
Query: 346 PLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGE 405
L E EA R + ++ + A ++++ + A K +A+E +
Sbjct: 2082 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK--------QSAEEQAQARA 2133
Query: 406 KLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQE 465
+ QA + K E + AQ EQ L+ K+ A A +E+ K + + QE
Sbjct: 2134 QAQAAAEKLRKEAEQEAARRAQAEQAA--LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2191
Query: 466 ADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQV 525
L +L+E + +EEL L+ E + ++ +E+E+ S+ Q++ L A++
Sbjct: 2192 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2251
Query: 526 SQHVSDLEEQKKQLIQDKDH----LSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSL 581
E + +++DKD+ L ++ ++++A L VA ++ + L
Sbjct: 2252 EA------ENRALILRDKDNTQRFLQEEAEKMKQVA-EEAARLSVAAQEA-------ARL 2297
Query: 582 QEAWGKPEEEQRGLQEAQLDDTK--VQEGSQ---EEELRQANRELEKELQNVVGRN---- 632
++ + +QR L E L + VQE ++ E EL Q +EL +E + +
Sbjct: 2298 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2357
Query: 633 -QLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAM 691
Q L + Q Q +A +QR+ + L+ A + + E RK E +
Sbjct: 2358 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2417
Query: 692 KAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ---CQQQTQLIEVLT 748
++ E Q K Q L + +Q AE + LE + QQ+ +L+++ +
Sbjct: 2418 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2477
Query: 749 AE----KGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALD 804
E + +Q + + L+ + +L Q + + Q E +L+ D AK + +
Sbjct: 2478 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ-EKAKLEQLFQDEVAKAQQLRE 2536
Query: 805 DQDKVQSQL---------SMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
+Q + Q Q+ SM EA R+H E E + R QE LQ E++
Sbjct: 2537 EQQRQQQQMEQERQRLVASMEEARRRQH--------EAEEGVRRK--QEELQQLEQQRRQ 2586
Query: 856 QEER-ADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHR--------ANTDTA 906
QEE A+E Q+ E+L+ L+E+ A SEE + L A
Sbjct: 2587 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2646
Query: 907 ELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQ-VAGLQQEKESLQE-K 964
E V +R++EA + +ELQ + + E R+ V Q + S+
Sbjct: 2647 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2706
Query: 965 LKAAKAAAGSLPGLQAQL 982
LKA LQ QL
Sbjct: 2707 LKATNEKLSVYAALQRQL 2724
Score = 104 bits (260), Expect = 6e-22
Identities = 248/1151 (21%), Positives = 429/1151 (37%), Gaps = 256/1151 (22%)
Query: 230 EGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNV 289
E + + EL+ E + K+L+ +L RE+ R V LQT+ +
Sbjct: 660 ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSW-------ML 712
Query: 290 RLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEE-DYHTALRRLESMLQPLA 348
+L C + K+ + V+E + LQ L+ K D + RLE +LQ
Sbjct: 713 QLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQ--- 769
Query: 349 QELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQ 408
D+ D+K Q L + G L+ ++A K P A M+ L
Sbjct: 770 -------DAQDEKEQ-LNEYKGHLSGLAKRAKAVVQLK------PRHPAHPMRGRLPLLA 815
Query: 409 ALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMA-----PLQE------ 457
+ ++ +V V++ QL + K + + E V + P QE
Sbjct: 816 VCDYKQVEV-TVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVT 874
Query: 458 ELSGKGQEADQLWRRLQELLAHTSSWEE-----------ELAELRREKKQQQ-------- 498
L + Q LW +L + +W+ LA R K ++Q
Sbjct: 875 RLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE 934
Query: 499 ------------------EEKELLEQEVRSLTRQLQFLETQLAQVSQH-------VSDLE 533
E++ + E+E S + Q L L Q +Q +S+L+
Sbjct: 935 LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 994
Query: 534 EQKKQLIQDKDHLSQQVGM----------LERLAGPPGPELPVAG--------------- 568
+ + QL + ++ + +R+A + V G
Sbjct: 995 DIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKV 1054
Query: 569 ----EKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTK----VQEGSQ-EEELRQANR 619
E + A + S L+ GK E+ R L L+ K V G+Q EE+ +A+
Sbjct: 1055 LALPEPSPAAPTLRSELELTLGK-LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE 1113
Query: 620 ELEKELQNVVGRNQLLE---GKLQALQADYQA---------------------LQQRE-- 653
E KE Q V LE L+ L+A +A LQQR
Sbjct: 1114 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1173
Query: 654 ----------------SAIQGSLASLEAEQASIRHLG----------DQMEASLLAVRKA 687
Q LA + Q + LG D + A L R+
Sbjct: 1174 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1233
Query: 688 KE-----------AMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ 736
+E A++ Q+ +++A+L+ E ++ E+VE+CQ+ A+ ++ E
Sbjct: 1234 QEQIQAMPLADSQAVREQLRQEQALLE----EIERHGEKVEECQRFAKQYINAIKDYE-- 1287
Query: 737 CQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQ-AQLEVHQGEVQRLQAQVVDL 795
++++T + + V P + ++ + + L H E+ L +Q +
Sbjct: 1288 -------LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1340
Query: 796 QAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
++ +++++++ Q E RE V+ E+ L AH Q Q L
Sbjct: 1341 ISETLRRMEEEERLAEQQRAEE---RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1397
Query: 856 QEERADEAQQREE-------ELRALQEELSQAKCSSE---EAQLEHAELQEQLH-RANTD 904
Q+ +E +REE + R++QEEL Q + SSE +A+ AE E+ R +
Sbjct: 1398 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1457
Query: 905 TAELGIQVCALTVEKERVE---EALACAVQELQDAKEAASREREGLERQVAGLQQEKESL 961
+ +Q+ A ++ E +AL +E + K A E E L RQV Q K
Sbjct: 1458 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1517
Query: 962 QEKL--------KAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKF-----QLS 1008
+ +L +AA+ +L L+ QAE+ + L++A + ++ Q S
Sbjct: 1518 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1577
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQLEE------------------QGRQLQAAEEAVEKLK 1050
AE + QS+ + E+ L L+E Q +A EEA +L+
Sbjct: 1578 AE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636
Query: 1051 ATQADMGEKLS--------CTSNHLAECQAAMLRKDKEGAALR----EDLERTQKEL-EK 1097
Q E L LA+ +A +++ E A R E+ Q+EL E+
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696
Query: 1098 ATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDA 1157
K ++ Q+ E+ ++ A+ + + ++ LEE L L R+ A QK
Sbjct: 1697 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1756
Query: 1158 LEFQ-QKLSAE 1167
LE + K+ AE
Sbjct: 1757 LEAELAKVRAE 1767
Score = 49.3 bits (116), Expect = 3e-05
Identities = 73/345 (21%), Positives = 147/345 (42%), Gaps = 24/345 (6%)
Query: 865 QREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRAN----TDTAELG---IQVCALTV 917
+RE++LR+ E L + + Q+E +EQL++A+ +D L + A V
Sbjct: 383 EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEV 442
Query: 918 EK--ERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL 975
E+ ++ + + ++Q K+ + E + R+V L + +++ + A +
Sbjct: 443 ERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAA 502
Query: 976 PGLQAQLAQAEQRAQSLQEAAHQELNTLKF--QLSAEIMDYQSRLKNA--GEECKSLRGQ 1031
P Q A+ QS+Q E +TL++ L A + + Q R+ A G + S+ Q
Sbjct: 503 PATQV----AQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ 558
Query: 1032 LEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERT 1091
L Q+ EE K++ ++D G+ T +C + R D + A L +
Sbjct: 559 LGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDC---LGRLDLQYAKLLNSSKAR 615
Query: 1092 QKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDAL 1151
+ LE + + +L + E+ ++++ D D N +E L+R+ +
Sbjct: 616 LRSLESLHSFVAAATKEL---MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 672
Query: 1152 WQKSDALE-FQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHC 1195
+K L+ +L E+ T + + ++SWM++ C
Sbjct: 673 EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCC 717
Score = 42.7 bits (99), Expect = 0.003
Identities = 56/242 (23%), Positives = 92/242 (38%), Gaps = 27/242 (11%)
Query: 197 RSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQL 256
+ + + L S +QT + L L D + +E + +L + Q
Sbjct: 2468 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2527
Query: 257 DRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQ 316
+ Q+LR +Q +Q++ ER+R LVA +++ + V+ Q
Sbjct: 2528 VAKAQQLREEQQRQQQQMEQERQR-------------LVASMEEARRRQHEAEEGVRRKQ 2574
Query: 317 TCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQ 376
LQ LE ++EE +RL LQ L E R +L + AS
Sbjct: 2575 EELQQLEQQRRQQEELLAEENQRLREQLQLLE---EQHRAALAHSEEVTASQVAATKTLP 2631
Query: 377 QKADTASDTKGRQEPIPS-------DAAQEMQELG----EKLQALERERTKVEEVNRQQS 425
D EP S +AQ +QE G E+LQ L + T V+E+ R++
Sbjct: 2632 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2691
Query: 426 AQ 427
+
Sbjct: 2692 VR 2693
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 162 bits (411), Expect = 2e-39
Identities = 240/1006 (23%), Positives = 425/1006 (42%), Gaps = 114/1006 (11%)
Query: 241 QLEVREKQLRERMQQLDRENQELRAAVSQQGE------QLQTERERGRTAAE-------- 286
+L+ + E+ QL+R QE AV+Q E Q Q E ER R AE
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1636
Query: 287 ---DNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESM 343
+ +RL E+ +Q + QA KE + + G AE++ L E
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKE-EAEREARRRGKAEEQAVRQRELAEQE-- 1693
Query: 344 LQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQEL 403
L+ Q E T Q L +Q+ + R + + A Q+ QEL
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 404 GEKLQALERE-------RTKVEEVNRQQSAQLEQLVKE-----LQLKEDA---RASLERL 448
+L + E + + EE +R S + +Q ++ +L E+A RA E
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1813
Query: 449 VKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEV 508
++ +E+ + + EA+++ L E LA E L+ E + +EKE + +
Sbjct: 1814 KRQRQLAEEDAARQRAEAERV---LAEKLAAIG----EATRLKTEAEIALKEKEAENERL 1866
Query: 509 RSLTRQLQFLETQLA-QVSQHVSDLEEQKKQLIQDKD-HLSQQVGMLE---RLAGPPGPE 563
R L F +L Q +QH +D+EE+ QL + D L +Q G++E R E
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926
Query: 564 LPVAGEKNEALVPVNSSLQEAWGK----PEEEQRGLQEAQLDDTKVQEGSQEEELRQANR 619
+ E + L+ G+ E+ R ++A+L+ + ++ + EEE R+ R
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 1984
Query: 620 ELEKELQNVVG--------RNQLLEGKLQALQADYQ-ALQQRESAIQGSLASLE-AEQAS 669
E E+ +Q + R LE +++ L+A + A + RE A Q S L+ A++A+
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 670 IRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRE 729
+ L + +A AV++ ++ ++ + +++++L GE + R E+ ++ RE
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2103
Query: 730 LRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQ 789
Q ++ +L + +AE+ Q AQ A + + E Q +R Q
Sbjct: 2104 AAQSRRQVEEAERLKQ--SAEEQAQA----------RAQAQAAAEKLRKEAEQEAARRAQ 2151
Query: 790 AQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCS 849
A+ L+ K A + ++ AE LR+ + Q+L L Q+ L
Sbjct: 2152 AEQAALRQKQAADAE----MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Query: 850 EREGALQEERADEAQQR---EEEL---RALQEELSQAKCSSE------------EAQLEH 891
E + L+ E + A+QR EEEL R EELS+ K E Q
Sbjct: 2208 ELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266
Query: 892 AELQEQLHRANTDTAELGIQVCALTVEKERVEEALA---CAVQELQDAKEAASREREGLE 948
E E++ + + A L + ++ EE LA +++ K A +E L+
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2326
Query: 949 RQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLS 1008
+ LQQ+KE QE+ + + + A+ Q QR + E++ +L
Sbjct: 2327 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLA 1068
+ + A E+ + R Q EE G +L E A ++ K T E S+H A
Sbjct: 2387 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDA 2445
Query: 1069 E-CQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADL 1127
E + A+ ++E L+++ + Q + E+ T QE +L QE + Q L++
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---QLLQET---QALQQSFLSEK 2499
Query: 1128 DDLNRTKKYLEE---RLIELLRDKDALWQK-SDALEFQQKLSAEER 1169
D L + ++++E+ +L +L +D+ A Q+ + + QQ+ +ER
Sbjct: 2500 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER 2545
Score = 157 bits (397), Expect = 7e-38
Identities = 245/1020 (24%), Positives = 438/1020 (42%), Gaps = 150/1020 (14%)
Query: 195 PSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQ 254
P ++ +SL Q + FD A E + ++ + +V ++ RER+
Sbjct: 1123 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1182
Query: 255 QLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEV--------TQ 306
QL Q + A + +L+ + R E L + + +++ E +Q
Sbjct: 1183 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 307 ATQNTVKELQTCLQGLELGAAEKEE-------------DYHTALRRLESMLQPLAQ---- 349
A + +++ Q L+ +E + EE DY L ++ L+P+A
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1302
Query: 350 -ELEATRDSLDKKNQHLAS-FPGWLAMAQQKADTASDTKGRQEP----IPSDAAQEMQEL 403
++++ +S+ ++ L + + + Q S+T R E A+E + L
Sbjct: 1303 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362
Query: 404 GEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKG 463
E ALE++R ++ E + Q AQ E+ KELQ +R+ +E+ +E
Sbjct: 1363 AEVEAALEKQR-QLAEAHAQAKAQAEREAKELQ---------QRMQEEVVRREEAAVDAQ 1412
Query: 464 QEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQ-- 521
Q+ + LQ+L S E E+ R+ + + + +E+E+R + QL+ E Q
Sbjct: 1413 QQKRSIQEELQQL---RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469
Query: 522 -----LAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLER--------LAGPPGPELPVAG 568
L + + E QK+Q ++ + L +QV + LA E A
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1529
Query: 569 EKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNV 628
EK AL +L+E + EE +R L++A+++ + + + E R A EL+ + +
Sbjct: 1530 EKQRAL----QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Query: 629 VGRNQLLEGKLQALQADYQALQQ-RESAIQGSLASLEAEQASIRHLGDQMEASLLAVR-K 686
+ LE ++LQ ++ A+ Q RE A + + EAE+A ++ E L + K
Sbjct: 1586 AEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQAEAERAR-----EEAERELERWQLK 1637
Query: 687 AKEAMKAQMAEKEAILQSK--EGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLI 744
A EA++ ++ +E Q + E ++ +EE E+ EAR R E Q +Q +L
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER-----EARRR--GKAEEQAVRQRELA 1690
Query: 745 EVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQR--LQAQVVDLQAKMRAA 802
E ++ Q G + LAA+ L + + E QGE QR L+ ++ LQ + AA
Sbjct: 1691 EQELEKQRQLAEG----TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1746
Query: 803 LDDQDKVQSQLSMAEAVL-----------REHKTLVQQLKEQNEALNRAHVQELLQCSER 851
+ +++++L+ A + E ++ ++ K++ EA +EL + + R
Sbjct: 1747 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-EAGRFRELAEEAAR 1805
Query: 852 EGALQEE--------RADEAQQREEELRALQEEL------SQAKCSSEEAQLEHAELQEQ 897
AL EE D A+QR E R L E+L ++ K +E A E E+
Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1865
Query: 898 LHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREG----LERQ--- 950
L R D A ++ R+EE A Q D +E ++ R+ LERQ
Sbjct: 1866 LRRLAEDEA----------FQRRRLEEQ---AAQHKADIEERLAQLRKASDSELERQKGL 1912
Query: 951 VAGLQQEKESLQEKLKAAKA----AAGSLPGLQAQLAQAEQRAQ-SLQEAAHQELNTLK- 1004
V +++ ++E++ A KA AA L+ +L + A+ +L+ EL +
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 1005 FQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKA------TQADMGE 1058
QL+AE + R + A E + EE RQ +AA E VE+LKA + E
Sbjct: 1973 RQLAAE---EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2029
Query: 1059 KLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRER 1118
+ S LA+ +AA R E A +++ ++EL++ + Q ++L E R
Sbjct: 2030 QESARQLQLAQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088
Score = 142 bits (357), Expect = 3e-33
Identities = 212/904 (23%), Positives = 386/904 (42%), Gaps = 127/904 (14%)
Query: 241 QLEVREKQLRERMQQL----DRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVA 296
+LE ++R M+ L R +E R+ + ++L+ E R R AE+ RL L
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811
Query: 297 ELQKQWEVTQ---ATQNTVKELQTCLQGLELGAAEK-EEDYHTALRRLES---MLQPLAQ 349
E ++Q ++ + A Q E + +G A + + + AL+ E+ L+ LA+
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1871
Query: 350 ELEATRDSLDKKN-QHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQ 408
+ R L+++ QH A LA ++ +D+ + RQ+ + D ++ +++ E++
Sbjct: 1872 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE---RQKGLVEDTLRQRRQVEEEIL 1928
Query: 409 ALERERTKVEEVNRQQSAQLEQLVKELQ--LKEDARASLERLVKEMAPLQEELSGKGQEA 466
AL+ K + +L ++ + L+ +A LE + +EE + +EA
Sbjct: 1929 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREA 1986
Query: 467 DQLWRRLQELLAHTSSWEEE----LAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQL 522
++ R+Q+ LA + L E+ R K + +E + L E+ + RQLQ +
Sbjct: 1987 EE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 523 -----AQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPV 577
A+ H +++++++L Q L Q+ +L++L G A E EA V
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQT---LQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2100
Query: 578 NSSLQEAWGKPEEEQRGLQ----------EAQLDDTKVQEGSQEEELRQA---------- 617
++ + EE +R Q +AQ K+++ +++E R+A
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2160
Query: 618 ---NRELEKE---LQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIR 671
+ E+EK + + + +E +L L+ + +++ + L L+AE
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2220
Query: 672 HLGDQMEASLLAVRKAKEAMKAQMAEKEA-----ILQSKEGECQQLREEVEQCQQLAEAR 726
Q+E L +VR E + A EA IL+ K+ + L+EE E+ +Q+AE
Sbjct: 2221 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2280
Query: 727 HR---------ELRAL-ESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQA 776
R LR L E QQ L E + EK Q EA L A+ L Q
Sbjct: 2281 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ------AVQEATRLKAEAELLQQ 2334
Query: 777 QLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEA 836
Q E+ Q + +RLQ +DK Q +AE +TL + + Q E
Sbjct: 2335 QKELAQEQARRLQ----------------EDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Query: 837 LNRAHVQELLQCSEREGALQEERADEAQQR-EEELRALQEELSQAKCSSEEAQLEHAELQ 895
A E L+ E + + RA+E QR ++ + E+L + + +++E L+
Sbjct: 2379 SAEA---ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2435
Query: 896 EQLHRANTDTAELGIQVCALTVEKERVEEALACA---------------VQELQDAKEAA 940
Q +++ D L + L EKE++++ +QE Q +++
Sbjct: 2436 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2495
Query: 941 SREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL-PGLQAQLAQAEQRAQ----SLQEA 995
E++ L ++ ++QEK L++ + A A L Q Q Q EQ Q S++EA
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555
Query: 996 AHQ----ELNTLKFQLSAEIMDYQSRLKN--AGEECKSLRGQLEEQGRQLQAAEEAVEKL 1049
+ E + Q + ++ Q R + EE + LR QL+ Q +AA E++
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615
Query: 1050 KATQ 1053
A+Q
Sbjct: 2616 TASQ 2619
Score = 129 bits (324), Expect = 2e-29
Identities = 207/880 (23%), Positives = 381/880 (43%), Gaps = 139/880 (15%)
Query: 385 TKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQ---LVKELQLKEDA 441
T G+ E + S +A +++L + + + R EEV R QL++ + L E
Sbjct: 1070 TLGKLEQVRSLSAIYLEKL-KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1128
Query: 442 RASLERLVKEMAP-------LQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREK 494
+ASL++L + L++EL G + ++L +R E W E +A+L
Sbjct: 1129 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1188
Query: 495 KQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQL----IQDKDHLSQQV 550
+ + ++ ++E+ L RQL++ + + D +++Q+ + D + +Q+
Sbjct: 1189 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1248
Query: 551 GMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDT------- 603
+ L E+ GEK E A K E Q +AQL+
Sbjct: 1249 RQEQALL----EEIERHGEKVEECQRFAKQYINAI-KDYELQLVTYKAQLEPVASPAKKP 1303
Query: 604 KVQEGSQE-----EELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQG 658
KVQ GS+ +LR EL + + + L+ ++ + + +Q+ + +
Sbjct: 1304 KVQSGSESVIQEYVDLRTHYSELTTLTSQYI---KFISETLRRMEEEERLAEQQRAEERE 1360
Query: 659 SLASLEAEQASIRHLGD-QMEASLLAVRKAKE---AMKAQMAEKEAILQSKEGECQQLRE 714
LA +EA R L + +A A R+AKE M+ ++ +E + + + ++E
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420
Query: 715 EVEQCQQLAE----ARHRELRALES---QCQQQTQLIEV-LTAEKGQQGVGPPTDNEARE 766
E++Q +Q +E A+ R+ A E + +++ +++ + L A + Q+G + E +
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG---GAEGELQA 1477
Query: 767 LAAQLALSQAQLEVHQGEVQRLQAQVVD-LQAKMRAALDDQDKVQSQLSMAEAVLREHKT 825
L A+ ++AQ Q E +RL+ QV D Q K +A ++ +V+++ A RE +
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA----REKQR 1533
Query: 826 LVQQLKE-------------QNEALNRAHVQELLQCSER--EGALQEERADEAQQREEEL 870
+Q L+E Q E VQ L+ ++R E LQ +RA A++ +
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593
Query: 871 RALQEE---LSQAKCSSEEAQLEHAELQEQLHRANTDTAELGI---QVCALTVEKERVEE 924
R+LQEE ++Q + +E + AE + A + + + L ++ E V +
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1653
Query: 925 ALACAVQELQDAKEAASRE--REGLERQVAGLQQE--KESLQEKLKAAK-------AAAG 973
+ A E + KE A RE R G + A Q+E ++ L+++ + A+ AA
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 974 SLPGLQAQLAQAEQRAQSLQE----------AAHQELNTLKFQLSAEIMDYQ-------- 1015
L L+A+ Q EQ+ Q L+E AA Q+ L+ +L+ + +
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Query: 1016 --------------------SRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKA-TQA 1054
R + EE LR EE RQ Q AEE + +A +
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1833
Query: 1055 DMGEKLSC---TSNHLAECQAAMLRKDKEGAALR-----EDLERTQKELEKATTK--IQE 1104
+ EKL+ + E + A+ K+ E LR E +R + E + A K I+E
Sbjct: 1834 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1893
Query: 1105 YYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIEL 1144
+L ++ ++ E QK L ++D R ++ +EE ++ L
Sbjct: 1894 RLAQL-RKASDSELERQKGL--VEDTLRQRRQVEEEILAL 1930
Score = 113 bits (282), Expect = 2e-24
Identities = 182/798 (22%), Positives = 328/798 (41%), Gaps = 88/798 (11%)
Query: 229 LEGFDEMRLELDQLEVREKQLRERMQQ---LDRENQELRAAVSQQGEQLQTERERGRTAA 285
LE + +L ++ E R ++ ER+Q+ + E R A ++ E+L+ + E R
Sbjct: 1967 LEAARQRQLAAEE-ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2025
Query: 286 EDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQ 345
E AE + ++ A + K LQ + +KE++ L++ +S+L
Sbjct: 2026 ER--------AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2077
Query: 346 PLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGE 405
L E EA R + ++ + A ++++ + A K +A+E +
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK--------QSAEEQAQARA 2129
Query: 406 KLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQE 465
+ QA + K E + AQ EQ L+ K+ A A +E+ K + + QE
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQAA--LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187
Query: 466 ADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQV 525
L +L+E + +EEL L+ E + ++ +E+E+ S+ Q++ L A++
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2247
Query: 526 SQHVSDLEEQKKQLIQDKDH----LSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSL 581
E + +++DKD+ L ++ ++++A L VA ++ + L
Sbjct: 2248 EA------ENRALILRDKDNTQRFLQEEAEKMKQVA-EEAARLSVAAQEA-------ARL 2293
Query: 582 QEAWGKPEEEQRGLQEAQLDDTK--VQEGSQ---EEELRQANRELEKELQNVVGRN---- 632
++ + +QR L E L + VQE ++ E EL Q +EL +E + +
Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353
Query: 633 -QLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAM 691
Q L + Q Q +A +QR+ + L+ A + + E RK E +
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413
Query: 692 KAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ---CQQQTQLIEVLT 748
++ E Q K Q L + +Q AE + LE + QQ+ +L+++ +
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2473
Query: 749 AE----KGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALD 804
E + +Q + + L+ + +L Q + + Q E +L+ D AK + +
Sbjct: 2474 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ-EKAKLEQLFQDEVAKAQQLRE 2532
Query: 805 DQDKVQSQL---------SMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
+Q + Q Q+ SM EA R+H E E + R QE LQ E++
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQH--------EAEEGVRRK--QEELQQLEQQRRQ 2582
Query: 856 QEER-ADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHR--------ANTDTA 906
QEE A+E Q+ E+L+ L+E+ A SEE + L A
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2642
Query: 907 ELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQ-VAGLQQEKESLQE-K 964
E V +R++EA + +ELQ + + E R+ V Q + S+
Sbjct: 2643 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2702
Query: 965 LKAAKAAAGSLPGLQAQL 982
LKA LQ QL
Sbjct: 2703 LKATNEKLSVYAALQRQL 2720
Score = 104 bits (260), Expect = 6e-22
Identities = 248/1151 (21%), Positives = 429/1151 (37%), Gaps = 256/1151 (22%)
Query: 230 EGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNV 289
E + + EL+ E + K+L+ +L RE+ R V LQT+ +
Sbjct: 656 ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSW-------ML 708
Query: 290 RLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEE-DYHTALRRLESMLQPLA 348
+L C + K+ + V+E + LQ L+ K D + RLE +LQ
Sbjct: 709 QLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQ--- 765
Query: 349 QELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQ 408
D+ D+K Q L + G L+ ++A K P A M+ L
Sbjct: 766 -------DAQDEKEQ-LNEYKGHLSGLAKRAKAVVQLK------PRHPAHPMRGRLPLLA 811
Query: 409 ALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMA-----PLQE------ 457
+ ++ +V V++ QL + K + + E V + P QE
Sbjct: 812 VCDYKQVEV-TVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVT 870
Query: 458 ELSGKGQEADQLWRRLQELLAHTSSWEE-----------ELAELRREKKQQQ-------- 498
L + Q LW +L + +W+ LA R K ++Q
Sbjct: 871 RLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE 930
Query: 499 ------------------EEKELLEQEVRSLTRQLQFLETQLAQVSQH-------VSDLE 533
E++ + E+E S + Q L L Q +Q +S+L+
Sbjct: 931 LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 990
Query: 534 EQKKQLIQDKDHLSQQVGM----------LERLAGPPGPELPVAG--------------- 568
+ + QL + ++ + +R+A + V G
Sbjct: 991 DIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKV 1050
Query: 569 ----EKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTK----VQEGSQ-EEELRQANR 619
E + A + S L+ GK E+ R L L+ K V G+Q EE+ +A+
Sbjct: 1051 LALPEPSPAAPTLRSELELTLGK-LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE 1109
Query: 620 ELEKELQNVVGRNQLLE---GKLQALQADYQA---------------------LQQRE-- 653
E KE Q V LE L+ L+A +A LQQR
Sbjct: 1110 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1169
Query: 654 ----------------SAIQGSLASLEAEQASIRHLG----------DQMEASLLAVRKA 687
Q LA + Q + LG D + A L R+
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1229
Query: 688 KE-----------AMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ 736
+E A++ Q+ +++A+L+ E ++ E+VE+CQ+ A+ ++ E
Sbjct: 1230 QEQIQAMPLADSQAVREQLRQEQALLE----EIERHGEKVEECQRFAKQYINAIKDYE-- 1283
Query: 737 CQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQ-AQLEVHQGEVQRLQAQVVDL 795
++++T + + V P + ++ + + L H E+ L +Q +
Sbjct: 1284 -------LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1336
Query: 796 QAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
++ +++++++ Q E RE V+ E+ L AH Q Q L
Sbjct: 1337 ISETLRRMEEEERLAEQQRAEE---RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1393
Query: 856 QEERADEAQQREE-------ELRALQEELSQAKCSSE---EAQLEHAELQEQLH-RANTD 904
Q+ +E +REE + R++QEEL Q + SSE +A+ AE E+ R +
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453
Query: 905 TAELGIQVCALTVEKERVE---EALACAVQELQDAKEAASREREGLERQVAGLQQEKESL 961
+ +Q+ A ++ E +AL +E + K A E E L RQV Q K
Sbjct: 1454 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513
Query: 962 QEKL--------KAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKF-----QLS 1008
+ +L +AA+ +L L+ QAE+ + L++A + ++ Q S
Sbjct: 1514 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1573
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQLEE------------------QGRQLQAAEEAVEKLK 1050
AE + QS+ + E+ L L+E Q +A EEA +L+
Sbjct: 1574 AE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Query: 1051 ATQADMGEKLS--------CTSNHLAECQAAMLRKDKEGAALR----EDLERTQKEL-EK 1097
Q E L LA+ +A +++ E A R E+ Q+EL E+
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 1098 ATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDA 1157
K ++ Q+ E+ ++ A+ + + ++ LEE L L R+ A QK
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752
Query: 1158 LEFQ-QKLSAE 1167
LE + K+ AE
Sbjct: 1753 LEAELAKVRAE 1763
Score = 49.3 bits (116), Expect = 3e-05
Identities = 73/345 (21%), Positives = 147/345 (42%), Gaps = 24/345 (6%)
Query: 865 QREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRAN----TDTAELG---IQVCALTV 917
+RE++LR+ E L + + Q+E +EQL++A+ +D L + A V
Sbjct: 379 EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEV 438
Query: 918 EK--ERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL 975
E+ ++ + + ++Q K+ + E + R+V L + +++ + A +
Sbjct: 439 ERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAA 498
Query: 976 PGLQAQLAQAEQRAQSLQEAAHQELNTLKF--QLSAEIMDYQSRLKNA--GEECKSLRGQ 1031
P Q A+ QS+Q E +TL++ L A + + Q R+ A G + S+ Q
Sbjct: 499 PATQV----AQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ 554
Query: 1032 LEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERT 1091
L Q+ EE K++ ++D G+ T +C + R D + A L +
Sbjct: 555 LGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDC---LGRLDLQYAKLLNSSKAR 611
Query: 1092 QKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDAL 1151
+ LE + + +L + E+ ++++ D D N +E L+R+ +
Sbjct: 612 LRSLESLHSFVAAATKEL---MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 668
Query: 1152 WQKSDALE-FQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHC 1195
+K L+ +L E+ T + + ++SWM++ C
Sbjct: 669 EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCC 713
Score = 42.7 bits (99), Expect = 0.003
Identities = 56/242 (23%), Positives = 92/242 (38%), Gaps = 27/242 (11%)
Query: 197 RSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQL 256
+ + + L S +QT + L L D + +E + +L + Q
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2523
Query: 257 DRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQ 316
+ Q+LR +Q +Q++ ER+R LVA +++ + V+ Q
Sbjct: 2524 VAKAQQLREEQQRQQQQMEQERQR-------------LVASMEEARRRQHEAEEGVRRKQ 2570
Query: 317 TCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQ 376
LQ LE ++EE +RL LQ L E R +L + AS
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQLLE---EQHRAALAHSEEVTASQVAATKTLP 2627
Query: 377 QKADTASDTKGRQEPIPS-------DAAQEMQELG----EKLQALERERTKVEEVNRQQS 425
D EP S +AQ +QE G E+LQ L + T V+E+ R++
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2687
Query: 426 AQ 427
+
Sbjct: 2688 VR 2689
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 162 bits (411), Expect = 2e-39
Identities = 240/1006 (23%), Positives = 425/1006 (42%), Gaps = 114/1006 (11%)
Query: 241 QLEVREKQLRERMQQLDRENQELRAAVSQQGE------QLQTERERGRTAAE-------- 286
+L+ + E+ QL+R QE AV+Q E Q Q E ER R AE
Sbjct: 1545 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1604
Query: 287 ---DNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESM 343
+ +RL E+ +Q + QA KE + + G AE++ L E
Sbjct: 1605 KANEALRLRLQAEEVAQQKSLAQAEAEKQKE-EAEREARRRGKAEEQAVRQRELAEQE-- 1661
Query: 344 LQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQEL 403
L+ Q E T Q L +Q+ + R + + A Q+ QEL
Sbjct: 1662 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1721
Query: 404 GEKLQALERE-------RTKVEEVNRQQSAQLEQLVKE-----LQLKEDA---RASLERL 448
+L + E + + EE +R S + +Q ++ +L E+A RA E
Sbjct: 1722 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1781
Query: 449 VKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEV 508
++ +E+ + + EA+++ L E LA E L+ E + +EKE + +
Sbjct: 1782 KRQRQLAEEDAARQRAEAERV---LAEKLAAIG----EATRLKTEAEIALKEKEAENERL 1834
Query: 509 RSLTRQLQFLETQLA-QVSQHVSDLEEQKKQLIQDKD-HLSQQVGMLE---RLAGPPGPE 563
R L F +L Q +QH +D+EE+ QL + D L +Q G++E R E
Sbjct: 1835 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1894
Query: 564 LPVAGEKNEALVPVNSSLQEAWGK----PEEEQRGLQEAQLDDTKVQEGSQEEELRQANR 619
+ E + L+ G+ E+ R ++A+L+ + ++ + EEE R+ R
Sbjct: 1895 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 1952
Query: 620 ELEKELQNVVG--------RNQLLEGKLQALQADYQ-ALQQRESAIQGSLASLE-AEQAS 669
E E+ +Q + R LE +++ L+A + A + RE A Q S L+ A++A+
Sbjct: 1953 EAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2011
Query: 670 IRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRE 729
+ L + +A AV++ ++ ++ + +++++L GE + R E+ ++ RE
Sbjct: 2012 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2071
Query: 730 LRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQ 789
Q ++ +L + +AE+ Q AQ A + + E Q +R Q
Sbjct: 2072 AAQSRRQVEEAERLKQ--SAEEQAQA----------RAQAQAAAEKLRKEAEQEAARRAQ 2119
Query: 790 AQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCS 849
A+ L+ K A + ++ AE LR+ + Q+L L Q+ L
Sbjct: 2120 AEQAALRQKQAADAE----MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2175
Query: 850 EREGALQEERADEAQQR---EEEL---RALQEELSQAKCSSE------------EAQLEH 891
E + L+ E + A+QR EEEL R EELS+ K E Q
Sbjct: 2176 ELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2234
Query: 892 AELQEQLHRANTDTAELGIQVCALTVEKERVEEALA---CAVQELQDAKEAASREREGLE 948
E E++ + + A L + ++ EE LA +++ K A +E L+
Sbjct: 2235 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2294
Query: 949 RQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLS 1008
+ LQQ+KE QE+ + + + A+ Q QR + E++ +L
Sbjct: 2295 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2354
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLA 1068
+ + A E+ + R Q EE G +L E A ++ K T E S+H A
Sbjct: 2355 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDA 2413
Query: 1069 E-CQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADL 1127
E + A+ ++E L+++ + Q + E+ T QE +L QE + Q L++
Sbjct: 2414 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---QLLQET---QALQQSFLSEK 2467
Query: 1128 DDLNRTKKYLEE---RLIELLRDKDALWQK-SDALEFQQKLSAEER 1169
D L + ++++E+ +L +L +D+ A Q+ + + QQ+ +ER
Sbjct: 2468 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER 2513
Score = 157 bits (397), Expect = 7e-38
Identities = 245/1020 (24%), Positives = 438/1020 (42%), Gaps = 150/1020 (14%)
Query: 195 PSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQ 254
P ++ +SL Q + FD A E + ++ + +V ++ RER+
Sbjct: 1091 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1150
Query: 255 QLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEV--------TQ 306
QL Q + A + +L+ + R E L + + +++ E +Q
Sbjct: 1151 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1210
Query: 307 ATQNTVKELQTCLQGLELGAAEKEE-------------DYHTALRRLESMLQPLAQ---- 349
A + +++ Q L+ +E + EE DY L ++ L+P+A
Sbjct: 1211 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1270
Query: 350 -ELEATRDSLDKKNQHLAS-FPGWLAMAQQKADTASDTKGRQEP----IPSDAAQEMQEL 403
++++ +S+ ++ L + + + Q S+T R E A+E + L
Sbjct: 1271 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1330
Query: 404 GEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKG 463
E ALE++R ++ E + Q AQ E+ KELQ +R+ +E+ +E
Sbjct: 1331 AEVEAALEKQR-QLAEAHAQAKAQAEREAKELQ---------QRMQEEVVRREEAAVDAQ 1380
Query: 464 QEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQ-- 521
Q+ + LQ+L S E E+ R+ + + + +E+E+R + QL+ E Q
Sbjct: 1381 QQKRSIQEELQQL---RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1437
Query: 522 -----LAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLER--------LAGPPGPELPVAG 568
L + + E QK+Q ++ + L +QV + LA E A
Sbjct: 1438 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1497
Query: 569 EKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNV 628
EK AL +L+E + EE +R L++A+++ + + + E R A EL+ + +
Sbjct: 1498 EKQRAL----QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1553
Query: 629 VGRNQLLEGKLQALQADYQALQQ-RESAIQGSLASLEAEQASIRHLGDQMEASLLAVR-K 686
+ LE ++LQ ++ A+ Q RE A + + EAE+A ++ E L + K
Sbjct: 1554 AEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQAEAERAR-----EEAERELERWQLK 1605
Query: 687 AKEAMKAQMAEKEAILQSK--EGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLI 744
A EA++ ++ +E Q + E ++ +EE E+ EAR R E Q +Q +L
Sbjct: 1606 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER-----EARRR--GKAEEQAVRQRELA 1658
Query: 745 EVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQR--LQAQVVDLQAKMRAA 802
E ++ Q G + LAA+ L + + E QGE QR L+ ++ LQ + AA
Sbjct: 1659 EQELEKQRQLAEG----TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1714
Query: 803 LDDQDKVQSQLSMAEAVL-----------REHKTLVQQLKEQNEALNRAHVQELLQCSER 851
+ +++++L+ A + E ++ ++ K++ EA +EL + + R
Sbjct: 1715 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-EAGRFRELAEEAAR 1773
Query: 852 EGALQEE--------RADEAQQREEELRALQEEL------SQAKCSSEEAQLEHAELQEQ 897
AL EE D A+QR E R L E+L ++ K +E A E E+
Sbjct: 1774 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1833
Query: 898 LHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREG----LERQ--- 950
L R D A ++ R+EE A Q D +E ++ R+ LERQ
Sbjct: 1834 LRRLAEDEA----------FQRRRLEEQ---AAQHKADIEERLAQLRKASDSELERQKGL 1880
Query: 951 VAGLQQEKESLQEKLKAAKA----AAGSLPGLQAQLAQAEQRAQ-SLQEAAHQELNTLK- 1004
V +++ ++E++ A KA AA L+ +L + A+ +L+ EL +
Sbjct: 1881 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1940
Query: 1005 FQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKA------TQADMGE 1058
QL+AE + R + A E + EE RQ +AA E VE+LKA + E
Sbjct: 1941 RQLAAE---EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 1997
Query: 1059 KLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRER 1118
+ S LA+ +AA R E A +++ ++EL++ + Q ++L E R
Sbjct: 1998 QESARQLQLAQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2056
Score = 142 bits (357), Expect = 3e-33
Identities = 212/904 (23%), Positives = 386/904 (42%), Gaps = 127/904 (14%)
Query: 241 QLEVREKQLRERMQQL----DRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVA 296
+LE ++R M+ L R +E R+ + ++L+ E R R AE+ RL L
Sbjct: 1720 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1779
Query: 297 ELQKQWEVTQ---ATQNTVKELQTCLQGLELGAAEK-EEDYHTALRRLES---MLQPLAQ 349
E ++Q ++ + A Q E + +G A + + + AL+ E+ L+ LA+
Sbjct: 1780 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1839
Query: 350 ELEATRDSLDKKN-QHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQ 408
+ R L+++ QH A LA ++ +D+ + RQ+ + D ++ +++ E++
Sbjct: 1840 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE---RQKGLVEDTLRQRRQVEEEIL 1896
Query: 409 ALERERTKVEEVNRQQSAQLEQLVKELQ--LKEDARASLERLVKEMAPLQEELSGKGQEA 466
AL+ K + +L ++ + L+ +A LE + +EE + +EA
Sbjct: 1897 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREA 1954
Query: 467 DQLWRRLQELLAHTSSWEEE----LAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQL 522
++ R+Q+ LA + L E+ R K + +E + L E+ + RQLQ +
Sbjct: 1955 EE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2011
Query: 523 -----AQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPV 577
A+ H +++++++L Q L Q+ +L++L G A E EA V
Sbjct: 2012 QKRLQAEEKAHAFAVQQKEQELQQT---LQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2068
Query: 578 NSSLQEAWGKPEEEQRGLQ----------EAQLDDTKVQEGSQEEELRQA---------- 617
++ + EE +R Q +AQ K+++ +++E R+A
Sbjct: 2069 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2128
Query: 618 ---NRELEKE---LQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIR 671
+ E+EK + + + +E +L L+ + +++ + L L+AE
Sbjct: 2129 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2188
Query: 672 HLGDQMEASLLAVRKAKEAMKAQMAEKEA-----ILQSKEGECQQLREEVEQCQQLAEAR 726
Q+E L +VR E + A EA IL+ K+ + L+EE E+ +Q+AE
Sbjct: 2189 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2248
Query: 727 HR---------ELRAL-ESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQA 776
R LR L E QQ L E + EK Q EA L A+ L Q
Sbjct: 2249 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ------AVQEATRLKAEAELLQQ 2302
Query: 777 QLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEA 836
Q E+ Q + +RLQ +DK Q +AE +TL + + Q E
Sbjct: 2303 QKELAQEQARRLQ----------------EDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2346
Query: 837 LNRAHVQELLQCSEREGALQEERADEAQQR-EEELRALQEELSQAKCSSEEAQLEHAELQ 895
A E L+ E + + RA+E QR ++ + E+L + + +++E L+
Sbjct: 2347 SAEA---ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2403
Query: 896 EQLHRANTDTAELGIQVCALTVEKERVEEALACA---------------VQELQDAKEAA 940
Q +++ D L + L EKE++++ +QE Q +++
Sbjct: 2404 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2463
Query: 941 SREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL-PGLQAQLAQAEQRAQ----SLQEA 995
E++ L ++ ++QEK L++ + A A L Q Q Q EQ Q S++EA
Sbjct: 2464 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2523
Query: 996 AHQ----ELNTLKFQLSAEIMDYQSRLKN--AGEECKSLRGQLEEQGRQLQAAEEAVEKL 1049
+ E + Q + ++ Q R + EE + LR QL+ Q +AA E++
Sbjct: 2524 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2583
Query: 1050 KATQ 1053
A+Q
Sbjct: 2584 TASQ 2587
Score = 129 bits (324), Expect = 2e-29
Identities = 207/880 (23%), Positives = 381/880 (43%), Gaps = 139/880 (15%)
Query: 385 TKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQ---LVKELQLKEDA 441
T G+ E + S +A +++L + + + R EEV R QL++ + L E
Sbjct: 1038 TLGKLEQVRSLSAIYLEKL-KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1096
Query: 442 RASLERLVKEMAP-------LQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREK 494
+ASL++L + L++EL G + ++L +R E W E +A+L
Sbjct: 1097 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1156
Query: 495 KQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQL----IQDKDHLSQQV 550
+ + ++ ++E+ L RQL++ + + D +++Q+ + D + +Q+
Sbjct: 1157 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1216
Query: 551 GMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDT------- 603
+ L E+ GEK E A K E Q +AQL+
Sbjct: 1217 RQEQALL----EEIERHGEKVEECQRFAKQYINAI-KDYELQLVTYKAQLEPVASPAKKP 1271
Query: 604 KVQEGSQE-----EELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQG 658
KVQ GS+ +LR EL + + + L+ ++ + + +Q+ + +
Sbjct: 1272 KVQSGSESVIQEYVDLRTHYSELTTLTSQYI---KFISETLRRMEEEERLAEQQRAEERE 1328
Query: 659 SLASLEAEQASIRHLGD-QMEASLLAVRKAKE---AMKAQMAEKEAILQSKEGECQQLRE 714
LA +EA R L + +A A R+AKE M+ ++ +E + + + ++E
Sbjct: 1329 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1388
Query: 715 EVEQCQQLAE----ARHRELRALES---QCQQQTQLIEV-LTAEKGQQGVGPPTDNEARE 766
E++Q +Q +E A+ R+ A E + +++ +++ + L A + Q+G + E +
Sbjct: 1389 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG---GAEGELQA 1445
Query: 767 LAAQLALSQAQLEVHQGEVQRLQAQVVD-LQAKMRAALDDQDKVQSQLSMAEAVLREHKT 825
L A+ ++AQ Q E +RL+ QV D Q K +A ++ +V+++ A RE +
Sbjct: 1446 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA----REKQR 1501
Query: 826 LVQQLKE-------------QNEALNRAHVQELLQCSER--EGALQEERADEAQQREEEL 870
+Q L+E Q E VQ L+ ++R E LQ +RA A++ +
Sbjct: 1502 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1561
Query: 871 RALQEE---LSQAKCSSEEAQLEHAELQEQLHRANTDTAELGI---QVCALTVEKERVEE 924
R+LQEE ++Q + +E + AE + A + + + L ++ E V +
Sbjct: 1562 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1621
Query: 925 ALACAVQELQDAKEAASRE--REGLERQVAGLQQE--KESLQEKLKAAK-------AAAG 973
+ A E + KE A RE R G + A Q+E ++ L+++ + A+ AA
Sbjct: 1622 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1681
Query: 974 SLPGLQAQLAQAEQRAQSLQE----------AAHQELNTLKFQLSAEIMDYQ-------- 1015
L L+A+ Q EQ+ Q L+E AA Q+ L+ +L+ + +
Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1741
Query: 1016 --------------------SRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKA-TQA 1054
R + EE LR EE RQ Q AEE + +A +
Sbjct: 1742 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1801
Query: 1055 DMGEKLSC---TSNHLAECQAAMLRKDKEGAALR-----EDLERTQKELEKATTK--IQE 1104
+ EKL+ + E + A+ K+ E LR E +R + E + A K I+E
Sbjct: 1802 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1861
Query: 1105 YYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIEL 1144
+L ++ ++ E QK L ++D R ++ +EE ++ L
Sbjct: 1862 RLAQL-RKASDSELERQKGL--VEDTLRQRRQVEEEILAL 1898
Score = 113 bits (282), Expect = 2e-24
Identities = 182/798 (22%), Positives = 328/798 (41%), Gaps = 88/798 (11%)
Query: 229 LEGFDEMRLELDQLEVREKQLRERMQQ---LDRENQELRAAVSQQGEQLQTERERGRTAA 285
LE + +L ++ E R ++ ER+Q+ + E R A ++ E+L+ + E R
Sbjct: 1935 LEAARQRQLAAEE-ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 1993
Query: 286 EDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQ 345
E AE + ++ A + K LQ + +KE++ L++ +S+L
Sbjct: 1994 ER--------AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2045
Query: 346 PLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGE 405
L E EA R + ++ + A ++++ + A K +A+E +
Sbjct: 2046 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK--------QSAEEQAQARA 2097
Query: 406 KLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQE 465
+ QA + K E + AQ EQ L+ K+ A A +E+ K + + QE
Sbjct: 2098 QAQAAAEKLRKEAEQEAARRAQAEQAA--LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2155
Query: 466 ADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQV 525
L +L+E + +EEL L+ E + ++ +E+E+ S+ Q++ L A++
Sbjct: 2156 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2215
Query: 526 SQHVSDLEEQKKQLIQDKDH----LSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSL 581
E + +++DKD+ L ++ ++++A L VA ++ + L
Sbjct: 2216 EA------ENRALILRDKDNTQRFLQEEAEKMKQVA-EEAARLSVAAQEA-------ARL 2261
Query: 582 QEAWGKPEEEQRGLQEAQLDDTK--VQEGSQ---EEELRQANRELEKELQNVVGRN---- 632
++ + +QR L E L + VQE ++ E EL Q +EL +E + +
Sbjct: 2262 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2321
Query: 633 -QLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAM 691
Q L + Q Q +A +QR+ + L+ A + + E RK E +
Sbjct: 2322 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2381
Query: 692 KAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ---CQQQTQLIEVLT 748
++ E Q K Q L + +Q AE + LE + QQ+ +L+++ +
Sbjct: 2382 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2441
Query: 749 AE----KGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALD 804
E + +Q + + L+ + +L Q + + Q E +L+ D AK + +
Sbjct: 2442 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ-EKAKLEQLFQDEVAKAQQLRE 2500
Query: 805 DQDKVQSQL---------SMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
+Q + Q Q+ SM EA R+H E E + R QE LQ E++
Sbjct: 2501 EQQRQQQQMEQERQRLVASMEEARRRQH--------EAEEGVRRK--QEELQQLEQQRRQ 2550
Query: 856 QEER-ADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHR--------ANTDTA 906
QEE A+E Q+ E+L+ L+E+ A SEE + L A
Sbjct: 2551 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2610
Query: 907 ELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQ-VAGLQQEKESLQE-K 964
E V +R++EA + +ELQ + + E R+ V Q + S+
Sbjct: 2611 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2670
Query: 965 LKAAKAAAGSLPGLQAQL 982
LKA LQ QL
Sbjct: 2671 LKATNEKLSVYAALQRQL 2688
Score = 104 bits (260), Expect = 6e-22
Identities = 248/1151 (21%), Positives = 429/1151 (37%), Gaps = 256/1151 (22%)
Query: 230 EGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNV 289
E + + EL+ E + K+L+ +L RE+ R V LQT+ +
Sbjct: 624 ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSW-------ML 676
Query: 290 RLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEE-DYHTALRRLESMLQPLA 348
+L C + K+ + V+E + LQ L+ K D + RLE +LQ
Sbjct: 677 QLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQ--- 733
Query: 349 QELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQ 408
D+ D+K Q L + G L+ ++A K P A M+ L
Sbjct: 734 -------DAQDEKEQ-LNEYKGHLSGLAKRAKAVVQLK------PRHPAHPMRGRLPLLA 779
Query: 409 ALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMA-----PLQE------ 457
+ ++ +V V++ QL + K + + E V + P QE
Sbjct: 780 VCDYKQVEV-TVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVT 838
Query: 458 ELSGKGQEADQLWRRLQELLAHTSSWEE-----------ELAELRREKKQQQ-------- 498
L + Q LW +L + +W+ LA R K ++Q
Sbjct: 839 RLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE 898
Query: 499 ------------------EEKELLEQEVRSLTRQLQFLETQLAQVSQH-------VSDLE 533
E++ + E+E S + Q L L Q +Q +S+L+
Sbjct: 899 LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 958
Query: 534 EQKKQLIQDKDHLSQQVGM----------LERLAGPPGPELPVAG--------------- 568
+ + QL + ++ + +R+A + V G
Sbjct: 959 DIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKV 1018
Query: 569 ----EKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTK----VQEGSQ-EEELRQANR 619
E + A + S L+ GK E+ R L L+ K V G+Q EE+ +A+
Sbjct: 1019 LALPEPSPAAPTLRSELELTLGK-LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE 1077
Query: 620 ELEKELQNVVGRNQLLE---GKLQALQADYQA---------------------LQQRE-- 653
E KE Q V LE L+ L+A +A LQQR
Sbjct: 1078 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1137
Query: 654 ----------------SAIQGSLASLEAEQASIRHLG----------DQMEASLLAVRKA 687
Q LA + Q + LG D + A L R+
Sbjct: 1138 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1197
Query: 688 KE-----------AMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ 736
+E A++ Q+ +++A+L+ E ++ E+VE+CQ+ A+ ++ E
Sbjct: 1198 QEQIQAMPLADSQAVREQLRQEQALLE----EIERHGEKVEECQRFAKQYINAIKDYE-- 1251
Query: 737 CQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQ-AQLEVHQGEVQRLQAQVVDL 795
++++T + + V P + ++ + + L H E+ L +Q +
Sbjct: 1252 -------LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1304
Query: 796 QAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
++ +++++++ Q E RE V+ E+ L AH Q Q L
Sbjct: 1305 ISETLRRMEEEERLAEQQRAEE---RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1361
Query: 856 QEERADEAQQREE-------ELRALQEELSQAKCSSE---EAQLEHAELQEQLH-RANTD 904
Q+ +E +REE + R++QEEL Q + SSE +A+ AE E+ R +
Sbjct: 1362 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1421
Query: 905 TAELGIQVCALTVEKERVE---EALACAVQELQDAKEAASREREGLERQVAGLQQEKESL 961
+ +Q+ A ++ E +AL +E + K A E E L RQV Q K
Sbjct: 1422 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1481
Query: 962 QEKL--------KAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKF-----QLS 1008
+ +L +AA+ +L L+ QAE+ + L++A + ++ Q S
Sbjct: 1482 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1541
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQLEE------------------QGRQLQAAEEAVEKLK 1050
AE + QS+ + E+ L L+E Q +A EEA +L+
Sbjct: 1542 AE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600
Query: 1051 ATQADMGEKLS--------CTSNHLAECQAAMLRKDKEGAALR----EDLERTQKEL-EK 1097
Q E L LA+ +A +++ E A R E+ Q+EL E+
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1660
Query: 1098 ATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDA 1157
K ++ Q+ E+ ++ A+ + + ++ LEE L L R+ A QK
Sbjct: 1661 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1720
Query: 1158 LEFQ-QKLSAE 1167
LE + K+ AE
Sbjct: 1721 LEAELAKVRAE 1731
Score = 49.3 bits (116), Expect = 3e-05
Identities = 73/345 (21%), Positives = 147/345 (42%), Gaps = 24/345 (6%)
Query: 865 QREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRAN----TDTAELG---IQVCALTV 917
+RE++LR+ E L + + Q+E +EQL++A+ +D L + A V
Sbjct: 347 EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEV 406
Query: 918 EK--ERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL 975
E+ ++ + + ++Q K+ + E + R+V L + +++ + A +
Sbjct: 407 ERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAA 466
Query: 976 PGLQAQLAQAEQRAQSLQEAAHQELNTLKF--QLSAEIMDYQSRLKNA--GEECKSLRGQ 1031
P Q A+ QS+Q E +TL++ L A + + Q R+ A G + S+ Q
Sbjct: 467 PATQV----AQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ 522
Query: 1032 LEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERT 1091
L Q+ EE K++ ++D G+ T +C + R D + A L +
Sbjct: 523 LGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDC---LGRLDLQYAKLLNSSKAR 579
Query: 1092 QKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDAL 1151
+ LE + + +L + E+ ++++ D D N +E L+R+ +
Sbjct: 580 LRSLESLHSFVAAATKEL---MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 636
Query: 1152 WQKSDALE-FQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHC 1195
+K L+ +L E+ T + + ++SWM++ C
Sbjct: 637 EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCC 681
Score = 42.7 bits (99), Expect = 0.003
Identities = 56/242 (23%), Positives = 92/242 (38%), Gaps = 27/242 (11%)
Query: 197 RSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQL 256
+ + + L S +QT + L L D + +E + +L + Q
Sbjct: 2432 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2491
Query: 257 DRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQ 316
+ Q+LR +Q +Q++ ER+R LVA +++ + V+ Q
Sbjct: 2492 VAKAQQLREEQQRQQQQMEQERQR-------------LVASMEEARRRQHEAEEGVRRKQ 2538
Query: 317 TCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQ 376
LQ LE ++EE +RL LQ L E R +L + AS
Sbjct: 2539 EELQQLEQQRRQQEELLAEENQRLREQLQLLE---EQHRAALAHSEEVTASQVAATKTLP 2595
Query: 377 QKADTASDTKGRQEPIPS-------DAAQEMQELG----EKLQALERERTKVEEVNRQQS 425
D EP S +AQ +QE G E+LQ L + T V+E+ R++
Sbjct: 2596 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2655
Query: 426 AQ 427
+
Sbjct: 2656 VR 2657
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 162 bits (411), Expect = 2e-39
Identities = 240/1006 (23%), Positives = 425/1006 (42%), Gaps = 114/1006 (11%)
Query: 241 QLEVREKQLRERMQQLDRENQELRAAVSQQGE------QLQTERERGRTAAE-------- 286
+L+ + E+ QL+R QE AV+Q E Q Q E ER R AE
Sbjct: 1714 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1773
Query: 287 ---DNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESM 343
+ +RL E+ +Q + QA KE + + G AE++ L E
Sbjct: 1774 KANEALRLRLQAEEVAQQKSLAQAEAEKQKE-EAEREARRRGKAEEQAVRQRELAEQE-- 1830
Query: 344 LQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQEL 403
L+ Q E T Q L +Q+ + R + + A Q+ QEL
Sbjct: 1831 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1890
Query: 404 GEKLQALERE-------RTKVEEVNRQQSAQLEQLVKE-----LQLKEDA---RASLERL 448
+L + E + + EE +R S + +Q ++ +L E+A RA E
Sbjct: 1891 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1950
Query: 449 VKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEV 508
++ +E+ + + EA+++ L E LA E L+ E + +EKE + +
Sbjct: 1951 KRQRQLAEEDAARQRAEAERV---LAEKLAAIG----EATRLKTEAEIALKEKEAENERL 2003
Query: 509 RSLTRQLQFLETQLA-QVSQHVSDLEEQKKQLIQDKD-HLSQQVGMLE---RLAGPPGPE 563
R L F +L Q +QH +D+EE+ QL + D L +Q G++E R E
Sbjct: 2004 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 2063
Query: 564 LPVAGEKNEALVPVNSSLQEAWGK----PEEEQRGLQEAQLDDTKVQEGSQEEELRQANR 619
+ E + L+ G+ E+ R ++A+L+ + ++ + EEE R+ R
Sbjct: 2064 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 2121
Query: 620 ELEKELQNVVG--------RNQLLEGKLQALQADYQ-ALQQRESAIQGSLASLE-AEQAS 669
E E+ +Q + R LE +++ L+A + A + RE A Q S L+ A++A+
Sbjct: 2122 EAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2180
Query: 670 IRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRE 729
+ L + +A AV++ ++ ++ + +++++L GE + R E+ ++ RE
Sbjct: 2181 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2240
Query: 730 LRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQ 789
Q ++ +L + +AE+ Q AQ A + + E Q +R Q
Sbjct: 2241 AAQSRRQVEEAERLKQ--SAEEQAQA----------RAQAQAAAEKLRKEAEQEAARRAQ 2288
Query: 790 AQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCS 849
A+ L+ K A + ++ AE LR+ + Q+L L Q+ L
Sbjct: 2289 AEQAALRQKQAADAE----MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2344
Query: 850 EREGALQEERADEAQQR---EEEL---RALQEELSQAKCSSE------------EAQLEH 891
E + L+ E + A+QR EEEL R EELS+ K E Q
Sbjct: 2345 ELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2403
Query: 892 AELQEQLHRANTDTAELGIQVCALTVEKERVEEALA---CAVQELQDAKEAASREREGLE 948
E E++ + + A L + ++ EE LA +++ K A +E L+
Sbjct: 2404 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2463
Query: 949 RQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLS 1008
+ LQQ+KE QE+ + + + A+ Q QR + E++ +L
Sbjct: 2464 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2523
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLA 1068
+ + A E+ + R Q EE G +L E A ++ K T E S+H A
Sbjct: 2524 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDA 2582
Query: 1069 E-CQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADL 1127
E + A+ ++E L+++ + Q + E+ T QE +L QE + Q L++
Sbjct: 2583 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---QLLQET---QALQQSFLSEK 2636
Query: 1128 DDLNRTKKYLEE---RLIELLRDKDALWQK-SDALEFQQKLSAEER 1169
D L + ++++E+ +L +L +D+ A Q+ + + QQ+ +ER
Sbjct: 2637 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER 2682
Score = 157 bits (397), Expect = 7e-38
Identities = 245/1020 (24%), Positives = 438/1020 (42%), Gaps = 150/1020 (14%)
Query: 195 PSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQ 254
P ++ +SL Q + FD A E + ++ + +V ++ RER+
Sbjct: 1260 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1319
Query: 255 QLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEV--------TQ 306
QL Q + A + +L+ + R E L + + +++ E +Q
Sbjct: 1320 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1379
Query: 307 ATQNTVKELQTCLQGLELGAAEKEE-------------DYHTALRRLESMLQPLAQ---- 349
A + +++ Q L+ +E + EE DY L ++ L+P+A
Sbjct: 1380 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1439
Query: 350 -ELEATRDSLDKKNQHLAS-FPGWLAMAQQKADTASDTKGRQEP----IPSDAAQEMQEL 403
++++ +S+ ++ L + + + Q S+T R E A+E + L
Sbjct: 1440 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1499
Query: 404 GEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKG 463
E ALE++R ++ E + Q AQ E+ KELQ +R+ +E+ +E
Sbjct: 1500 AEVEAALEKQR-QLAEAHAQAKAQAEREAKELQ---------QRMQEEVVRREEAAVDAQ 1549
Query: 464 QEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQ-- 521
Q+ + LQ+L S E E+ R+ + + + +E+E+R + QL+ E Q
Sbjct: 1550 QQKRSIQEELQQL---RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1606
Query: 522 -----LAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLER--------LAGPPGPELPVAG 568
L + + E QK+Q ++ + L +QV + LA E A
Sbjct: 1607 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1666
Query: 569 EKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNV 628
EK AL +L+E + EE +R L++A+++ + + + E R A EL+ + +
Sbjct: 1667 EKQRAL----QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1722
Query: 629 VGRNQLLEGKLQALQADYQALQQ-RESAIQGSLASLEAEQASIRHLGDQMEASLLAVR-K 686
+ LE ++LQ ++ A+ Q RE A + + EAE+A ++ E L + K
Sbjct: 1723 AEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQAEAERAR-----EEAERELERWQLK 1774
Query: 687 AKEAMKAQMAEKEAILQSK--EGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLI 744
A EA++ ++ +E Q + E ++ +EE E+ EAR R E Q +Q +L
Sbjct: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER-----EARRR--GKAEEQAVRQRELA 1827
Query: 745 EVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQR--LQAQVVDLQAKMRAA 802
E ++ Q G + LAA+ L + + E QGE QR L+ ++ LQ + AA
Sbjct: 1828 EQELEKQRQLAEG----TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1883
Query: 803 LDDQDKVQSQLSMAEAVL-----------REHKTLVQQLKEQNEALNRAHVQELLQCSER 851
+ +++++L+ A + E ++ ++ K++ EA +EL + + R
Sbjct: 1884 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-EAGRFRELAEEAAR 1942
Query: 852 EGALQEE--------RADEAQQREEELRALQEEL------SQAKCSSEEAQLEHAELQEQ 897
AL EE D A+QR E R L E+L ++ K +E A E E+
Sbjct: 1943 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 2002
Query: 898 LHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREG----LERQ--- 950
L R D A ++ R+EE A Q D +E ++ R+ LERQ
Sbjct: 2003 LRRLAEDEA----------FQRRRLEEQ---AAQHKADIEERLAQLRKASDSELERQKGL 2049
Query: 951 VAGLQQEKESLQEKLKAAKA----AAGSLPGLQAQLAQAEQRAQ-SLQEAAHQELNTLK- 1004
V +++ ++E++ A KA AA L+ +L + A+ +L+ EL +
Sbjct: 2050 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 2109
Query: 1005 FQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKA------TQADMGE 1058
QL+AE + R + A E + EE RQ +AA E VE+LKA + E
Sbjct: 2110 RQLAAE---EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2166
Query: 1059 KLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRER 1118
+ S LA+ +AA R E A +++ ++EL++ + Q ++L E R
Sbjct: 2167 QESARQLQLAQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2225
Score = 142 bits (357), Expect = 3e-33
Identities = 212/904 (23%), Positives = 386/904 (42%), Gaps = 127/904 (14%)
Query: 241 QLEVREKQLRERMQQL----DRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVA 296
+LE ++R M+ L R +E R+ + ++L+ E R R AE+ RL L
Sbjct: 1889 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1948
Query: 297 ELQKQWEVTQ---ATQNTVKELQTCLQGLELGAAEK-EEDYHTALRRLES---MLQPLAQ 349
E ++Q ++ + A Q E + +G A + + + AL+ E+ L+ LA+
Sbjct: 1949 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 2008
Query: 350 ELEATRDSLDKKN-QHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQ 408
+ R L+++ QH A LA ++ +D+ + RQ+ + D ++ +++ E++
Sbjct: 2009 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE---RQKGLVEDTLRQRRQVEEEIL 2065
Query: 409 ALERERTKVEEVNRQQSAQLEQLVKELQ--LKEDARASLERLVKEMAPLQEELSGKGQEA 466
AL+ K + +L ++ + L+ +A LE + +EE + +EA
Sbjct: 2066 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREA 2123
Query: 467 DQLWRRLQELLAHTSSWEEE----LAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQL 522
++ R+Q+ LA + L E+ R K + +E + L E+ + RQLQ +
Sbjct: 2124 EE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2180
Query: 523 -----AQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPV 577
A+ H +++++++L Q L Q+ +L++L G A E EA V
Sbjct: 2181 QKRLQAEEKAHAFAVQQKEQELQQT---LQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2237
Query: 578 NSSLQEAWGKPEEEQRGLQ----------EAQLDDTKVQEGSQEEELRQA---------- 617
++ + EE +R Q +AQ K+++ +++E R+A
Sbjct: 2238 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2297
Query: 618 ---NRELEKE---LQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIR 671
+ E+EK + + + +E +L L+ + +++ + L L+AE
Sbjct: 2298 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2357
Query: 672 HLGDQMEASLLAVRKAKEAMKAQMAEKEA-----ILQSKEGECQQLREEVEQCQQLAEAR 726
Q+E L +VR E + A EA IL+ K+ + L+EE E+ +Q+AE
Sbjct: 2358 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2417
Query: 727 HR---------ELRAL-ESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQA 776
R LR L E QQ L E + EK Q EA L A+ L Q
Sbjct: 2418 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ------AVQEATRLKAEAELLQQ 2471
Query: 777 QLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEA 836
Q E+ Q + +RLQ +DK Q +AE +TL + + Q E
Sbjct: 2472 QKELAQEQARRLQ----------------EDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2515
Query: 837 LNRAHVQELLQCSEREGALQEERADEAQQR-EEELRALQEELSQAKCSSEEAQLEHAELQ 895
A E L+ E + + RA+E QR ++ + E+L + + +++E L+
Sbjct: 2516 SAEA---ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2572
Query: 896 EQLHRANTDTAELGIQVCALTVEKERVEEALACA---------------VQELQDAKEAA 940
Q +++ D L + L EKE++++ +QE Q +++
Sbjct: 2573 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2632
Query: 941 SREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL-PGLQAQLAQAEQRAQ----SLQEA 995
E++ L ++ ++QEK L++ + A A L Q Q Q EQ Q S++EA
Sbjct: 2633 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2692
Query: 996 AHQ----ELNTLKFQLSAEIMDYQSRLKN--AGEECKSLRGQLEEQGRQLQAAEEAVEKL 1049
+ E + Q + ++ Q R + EE + LR QL+ Q +AA E++
Sbjct: 2693 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2752
Query: 1050 KATQ 1053
A+Q
Sbjct: 2753 TASQ 2756
Score = 129 bits (324), Expect = 2e-29
Identities = 207/880 (23%), Positives = 381/880 (43%), Gaps = 139/880 (15%)
Query: 385 TKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQ---LVKELQLKEDA 441
T G+ E + S +A +++L + + + R EEV R QL++ + L E
Sbjct: 1207 TLGKLEQVRSLSAIYLEKL-KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1265
Query: 442 RASLERLVKEMAP-------LQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREK 494
+ASL++L + L++EL G + ++L +R E W E +A+L
Sbjct: 1266 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1325
Query: 495 KQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQL----IQDKDHLSQQV 550
+ + ++ ++E+ L RQL++ + + D +++Q+ + D + +Q+
Sbjct: 1326 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1385
Query: 551 GMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDT------- 603
+ L E+ GEK E A K E Q +AQL+
Sbjct: 1386 RQEQALL----EEIERHGEKVEECQRFAKQYINAI-KDYELQLVTYKAQLEPVASPAKKP 1440
Query: 604 KVQEGSQE-----EELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQG 658
KVQ GS+ +LR EL + + + L+ ++ + + +Q+ + +
Sbjct: 1441 KVQSGSESVIQEYVDLRTHYSELTTLTSQYI---KFISETLRRMEEEERLAEQQRAEERE 1497
Query: 659 SLASLEAEQASIRHLGD-QMEASLLAVRKAKE---AMKAQMAEKEAILQSKEGECQQLRE 714
LA +EA R L + +A A R+AKE M+ ++ +E + + + ++E
Sbjct: 1498 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1557
Query: 715 EVEQCQQLAE----ARHRELRALES---QCQQQTQLIEV-LTAEKGQQGVGPPTDNEARE 766
E++Q +Q +E A+ R+ A E + +++ +++ + L A + Q+G + E +
Sbjct: 1558 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG---GAEGELQA 1614
Query: 767 LAAQLALSQAQLEVHQGEVQRLQAQVVD-LQAKMRAALDDQDKVQSQLSMAEAVLREHKT 825
L A+ ++AQ Q E +RL+ QV D Q K +A ++ +V+++ A RE +
Sbjct: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA----REKQR 1670
Query: 826 LVQQLKE-------------QNEALNRAHVQELLQCSER--EGALQEERADEAQQREEEL 870
+Q L+E Q E VQ L+ ++R E LQ +RA A++ +
Sbjct: 1671 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1730
Query: 871 RALQEE---LSQAKCSSEEAQLEHAELQEQLHRANTDTAELGI---QVCALTVEKERVEE 924
R+LQEE ++Q + +E + AE + A + + + L ++ E V +
Sbjct: 1731 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1790
Query: 925 ALACAVQELQDAKEAASRE--REGLERQVAGLQQE--KESLQEKLKAAK-------AAAG 973
+ A E + KE A RE R G + A Q+E ++ L+++ + A+ AA
Sbjct: 1791 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1850
Query: 974 SLPGLQAQLAQAEQRAQSLQE----------AAHQELNTLKFQLSAEIMDYQ-------- 1015
L L+A+ Q EQ+ Q L+E AA Q+ L+ +L+ + +
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1910
Query: 1016 --------------------SRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKA-TQA 1054
R + EE LR EE RQ Q AEE + +A +
Sbjct: 1911 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1970
Query: 1055 DMGEKLSC---TSNHLAECQAAMLRKDKEGAALR-----EDLERTQKELEKATTK--IQE 1104
+ EKL+ + E + A+ K+ E LR E +R + E + A K I+E
Sbjct: 1971 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 2030
Query: 1105 YYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIEL 1144
+L ++ ++ E QK L ++D R ++ +EE ++ L
Sbjct: 2031 RLAQL-RKASDSELERQKGL--VEDTLRQRRQVEEEILAL 2067
Score = 113 bits (282), Expect = 2e-24
Identities = 182/798 (22%), Positives = 328/798 (41%), Gaps = 88/798 (11%)
Query: 229 LEGFDEMRLELDQLEVREKQLRERMQQ---LDRENQELRAAVSQQGEQLQTERERGRTAA 285
LE + +L ++ E R ++ ER+Q+ + E R A ++ E+L+ + E R
Sbjct: 2104 LEAARQRQLAAEE-ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2162
Query: 286 EDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQ 345
E AE + ++ A + K LQ + +KE++ L++ +S+L
Sbjct: 2163 ER--------AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2214
Query: 346 PLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGE 405
L E EA R + ++ + A ++++ + A K +A+E +
Sbjct: 2215 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK--------QSAEEQAQARA 2266
Query: 406 KLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQE 465
+ QA + K E + AQ EQ L+ K+ A A +E+ K + + QE
Sbjct: 2267 QAQAAAEKLRKEAEQEAARRAQAEQAA--LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2324
Query: 466 ADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQV 525
L +L+E + +EEL L+ E + ++ +E+E+ S+ Q++ L A++
Sbjct: 2325 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2384
Query: 526 SQHVSDLEEQKKQLIQDKDH----LSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSL 581
E + +++DKD+ L ++ ++++A L VA ++ + L
Sbjct: 2385 EA------ENRALILRDKDNTQRFLQEEAEKMKQVA-EEAARLSVAAQEA-------ARL 2430
Query: 582 QEAWGKPEEEQRGLQEAQLDDTK--VQEGSQ---EEELRQANRELEKELQNVVGRN---- 632
++ + +QR L E L + VQE ++ E EL Q +EL +E + +
Sbjct: 2431 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2490
Query: 633 -QLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAM 691
Q L + Q Q +A +QR+ + L+ A + + E RK E +
Sbjct: 2491 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2550
Query: 692 KAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ---CQQQTQLIEVLT 748
++ E Q K Q L + +Q AE + LE + QQ+ +L+++ +
Sbjct: 2551 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2610
Query: 749 AE----KGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALD 804
E + +Q + + L+ + +L Q + + Q E +L+ D AK + +
Sbjct: 2611 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ-EKAKLEQLFQDEVAKAQQLRE 2669
Query: 805 DQDKVQSQL---------SMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
+Q + Q Q+ SM EA R+H E E + R QE LQ E++
Sbjct: 2670 EQQRQQQQMEQERQRLVASMEEARRRQH--------EAEEGVRRK--QEELQQLEQQRRQ 2719
Query: 856 QEER-ADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHR--------ANTDTA 906
QEE A+E Q+ E+L+ L+E+ A SEE + L A
Sbjct: 2720 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2779
Query: 907 ELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQ-VAGLQQEKESLQE-K 964
E V +R++EA + +ELQ + + E R+ V Q + S+
Sbjct: 2780 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2839
Query: 965 LKAAKAAAGSLPGLQAQL 982
LKA LQ QL
Sbjct: 2840 LKATNEKLSVYAALQRQL 2857
Score = 104 bits (260), Expect = 6e-22
Identities = 248/1151 (21%), Positives = 429/1151 (37%), Gaps = 256/1151 (22%)
Query: 230 EGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNV 289
E + + EL+ E + K+L+ +L RE+ R V LQT+ +
Sbjct: 793 ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSW-------ML 845
Query: 290 RLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEE-DYHTALRRLESMLQPLA 348
+L C + K+ + V+E + LQ L+ K D + RLE +LQ
Sbjct: 846 QLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQ--- 902
Query: 349 QELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQ 408
D+ D+K Q L + G L+ ++A K P A M+ L
Sbjct: 903 -------DAQDEKEQ-LNEYKGHLSGLAKRAKAVVQLK------PRHPAHPMRGRLPLLA 948
Query: 409 ALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMA-----PLQE------ 457
+ ++ +V V++ QL + K + + E V + P QE
Sbjct: 949 VCDYKQVEV-TVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVT 1007
Query: 458 ELSGKGQEADQLWRRLQELLAHTSSWEE-----------ELAELRREKKQQQ-------- 498
L + Q LW +L + +W+ LA R K ++Q
Sbjct: 1008 RLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE 1067
Query: 499 ------------------EEKELLEQEVRSLTRQLQFLETQLAQVSQH-------VSDLE 533
E++ + E+E S + Q L L Q +Q +S+L+
Sbjct: 1068 LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 1127
Query: 534 EQKKQLIQDKDHLSQQVGM----------LERLAGPPGPELPVAG--------------- 568
+ + QL + ++ + +R+A + V G
Sbjct: 1128 DIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKV 1187
Query: 569 ----EKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTK----VQEGSQ-EEELRQANR 619
E + A + S L+ GK E+ R L L+ K V G+Q EE+ +A+
Sbjct: 1188 LALPEPSPAAPTLRSELELTLGK-LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE 1246
Query: 620 ELEKELQNVVGRNQLLE---GKLQALQADYQA---------------------LQQRE-- 653
E KE Q V LE L+ L+A +A LQQR
Sbjct: 1247 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1306
Query: 654 ----------------SAIQGSLASLEAEQASIRHLG----------DQMEASLLAVRKA 687
Q LA + Q + LG D + A L R+
Sbjct: 1307 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1366
Query: 688 KE-----------AMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ 736
+E A++ Q+ +++A+L+ E ++ E+VE+CQ+ A+ ++ E
Sbjct: 1367 QEQIQAMPLADSQAVREQLRQEQALLE----EIERHGEKVEECQRFAKQYINAIKDYE-- 1420
Query: 737 CQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQ-AQLEVHQGEVQRLQAQVVDL 795
++++T + + V P + ++ + + L H E+ L +Q +
Sbjct: 1421 -------LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1473
Query: 796 QAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
++ +++++++ Q E RE V+ E+ L AH Q Q L
Sbjct: 1474 ISETLRRMEEEERLAEQQRAEE---RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1530
Query: 856 QEERADEAQQREE-------ELRALQEELSQAKCSSE---EAQLEHAELQEQLH-RANTD 904
Q+ +E +REE + R++QEEL Q + SSE +A+ AE E+ R +
Sbjct: 1531 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1590
Query: 905 TAELGIQVCALTVEKERVE---EALACAVQELQDAKEAASREREGLERQVAGLQQEKESL 961
+ +Q+ A ++ E +AL +E + K A E E L RQV Q K
Sbjct: 1591 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1650
Query: 962 QEKL--------KAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKF-----QLS 1008
+ +L +AA+ +L L+ QAE+ + L++A + ++ Q S
Sbjct: 1651 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1710
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQLEE------------------QGRQLQAAEEAVEKLK 1050
AE + QS+ + E+ L L+E Q +A EEA +L+
Sbjct: 1711 AE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769
Query: 1051 ATQADMGEKLS--------CTSNHLAECQAAMLRKDKEGAALR----EDLERTQKEL-EK 1097
Q E L LA+ +A +++ E A R E+ Q+EL E+
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1829
Query: 1098 ATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDA 1157
K ++ Q+ E+ ++ A+ + + ++ LEE L L R+ A QK
Sbjct: 1830 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1889
Query: 1158 LEFQ-QKLSAE 1167
LE + K+ AE
Sbjct: 1890 LEAELAKVRAE 1900
Score = 49.3 bits (116), Expect = 3e-05
Identities = 73/345 (21%), Positives = 147/345 (42%), Gaps = 24/345 (6%)
Query: 865 QREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRAN----TDTAELG---IQVCALTV 917
+RE++LR+ E L + + Q+E +EQL++A+ +D L + A V
Sbjct: 516 EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEV 575
Query: 918 EK--ERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL 975
E+ ++ + + ++Q K+ + E + R+V L + +++ + A +
Sbjct: 576 ERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAA 635
Query: 976 PGLQAQLAQAEQRAQSLQEAAHQELNTLKF--QLSAEIMDYQSRLKNA--GEECKSLRGQ 1031
P Q A+ QS+Q E +TL++ L A + + Q R+ A G + S+ Q
Sbjct: 636 PATQV----AQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ 691
Query: 1032 LEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERT 1091
L Q+ EE K++ ++D G+ T +C + R D + A L +
Sbjct: 692 LGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDC---LGRLDLQYAKLLNSSKAR 748
Query: 1092 QKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDAL 1151
+ LE + + +L + E+ ++++ D D N +E L+R+ +
Sbjct: 749 LRSLESLHSFVAAATKEL---MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 805
Query: 1152 WQKSDALE-FQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHC 1195
+K L+ +L E+ T + + ++SWM++ C
Sbjct: 806 EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCC 850
Score = 42.7 bits (99), Expect = 0.003
Identities = 56/242 (23%), Positives = 92/242 (38%), Gaps = 27/242 (11%)
Query: 197 RSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQL 256
+ + + L S +QT + L L D + +E + +L + Q
Sbjct: 2601 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2660
Query: 257 DRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQ 316
+ Q+LR +Q +Q++ ER+R LVA +++ + V+ Q
Sbjct: 2661 VAKAQQLREEQQRQQQQMEQERQR-------------LVASMEEARRRQHEAEEGVRRKQ 2707
Query: 317 TCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQ 376
LQ LE ++EE +RL LQ L E R +L + AS
Sbjct: 2708 EELQQLEQQRRQQEELLAEENQRLREQLQLLE---EQHRAALAHSEEVTASQVAATKTLP 2764
Query: 377 QKADTASDTKGRQEPIPS-------DAAQEMQELG----EKLQALERERTKVEEVNRQQS 425
D EP S +AQ +QE G E+LQ L + T V+E+ R++
Sbjct: 2765 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2824
Query: 426 AQ 427
+
Sbjct: 2825 VR 2826
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 162 bits (411), Expect = 2e-39
Identities = 240/1006 (23%), Positives = 425/1006 (42%), Gaps = 114/1006 (11%)
Query: 241 QLEVREKQLRERMQQLDRENQELRAAVSQQGE------QLQTERERGRTAAE-------- 286
+L+ + E+ QL+R QE AV+Q E Q Q E ER R AE
Sbjct: 1555 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1614
Query: 287 ---DNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESM 343
+ +RL E+ +Q + QA KE + + G AE++ L E
Sbjct: 1615 KANEALRLRLQAEEVAQQKSLAQAEAEKQKE-EAEREARRRGKAEEQAVRQRELAEQE-- 1671
Query: 344 LQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQEL 403
L+ Q E T Q L +Q+ + R + + A Q+ QEL
Sbjct: 1672 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1731
Query: 404 GEKLQALERE-------RTKVEEVNRQQSAQLEQLVKE-----LQLKEDA---RASLERL 448
+L + E + + EE +R S + +Q ++ +L E+A RA E
Sbjct: 1732 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1791
Query: 449 VKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEV 508
++ +E+ + + EA+++ L E LA E L+ E + +EKE + +
Sbjct: 1792 KRQRQLAEEDAARQRAEAERV---LAEKLAAIG----EATRLKTEAEIALKEKEAENERL 1844
Query: 509 RSLTRQLQFLETQLA-QVSQHVSDLEEQKKQLIQDKD-HLSQQVGMLE---RLAGPPGPE 563
R L F +L Q +QH +D+EE+ QL + D L +Q G++E R E
Sbjct: 1845 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1904
Query: 564 LPVAGEKNEALVPVNSSLQEAWGK----PEEEQRGLQEAQLDDTKVQEGSQEEELRQANR 619
+ E + L+ G+ E+ R ++A+L+ + ++ + EEE R+ R
Sbjct: 1905 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 1962
Query: 620 ELEKELQNVVG--------RNQLLEGKLQALQADYQ-ALQQRESAIQGSLASLE-AEQAS 669
E E+ +Q + R LE +++ L+A + A + RE A Q S L+ A++A+
Sbjct: 1963 EAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2021
Query: 670 IRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRE 729
+ L + +A AV++ ++ ++ + +++++L GE + R E+ ++ RE
Sbjct: 2022 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2081
Query: 730 LRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQ 789
Q ++ +L + +AE+ Q AQ A + + E Q +R Q
Sbjct: 2082 AAQSRRQVEEAERLKQ--SAEEQAQA----------RAQAQAAAEKLRKEAEQEAARRAQ 2129
Query: 790 AQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCS 849
A+ L+ K A + ++ AE LR+ + Q+L L Q+ L
Sbjct: 2130 AEQAALRQKQAADAE----MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2185
Query: 850 EREGALQEERADEAQQR---EEEL---RALQEELSQAKCSSE------------EAQLEH 891
E + L+ E + A+QR EEEL R EELS+ K E Q
Sbjct: 2186 ELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2244
Query: 892 AELQEQLHRANTDTAELGIQVCALTVEKERVEEALA---CAVQELQDAKEAASREREGLE 948
E E++ + + A L + ++ EE LA +++ K A +E L+
Sbjct: 2245 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2304
Query: 949 RQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLS 1008
+ LQQ+KE QE+ + + + A+ Q QR + E++ +L
Sbjct: 2305 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2364
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLA 1068
+ + A E+ + R Q EE G +L E A ++ K T E S+H A
Sbjct: 2365 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDA 2423
Query: 1069 E-CQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADL 1127
E + A+ ++E L+++ + Q + E+ T QE +L QE + Q L++
Sbjct: 2424 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---QLLQET---QALQQSFLSEK 2477
Query: 1128 DDLNRTKKYLEE---RLIELLRDKDALWQK-SDALEFQQKLSAEER 1169
D L + ++++E+ +L +L +D+ A Q+ + + QQ+ +ER
Sbjct: 2478 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER 2523
Score = 157 bits (397), Expect = 7e-38
Identities = 245/1020 (24%), Positives = 438/1020 (42%), Gaps = 150/1020 (14%)
Query: 195 PSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQ 254
P ++ +SL Q + FD A E + ++ + +V ++ RER+
Sbjct: 1101 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1160
Query: 255 QLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEV--------TQ 306
QL Q + A + +L+ + R E L + + +++ E +Q
Sbjct: 1161 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1220
Query: 307 ATQNTVKELQTCLQGLELGAAEKEE-------------DYHTALRRLESMLQPLAQ---- 349
A + +++ Q L+ +E + EE DY L ++ L+P+A
Sbjct: 1221 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1280
Query: 350 -ELEATRDSLDKKNQHLAS-FPGWLAMAQQKADTASDTKGRQEP----IPSDAAQEMQEL 403
++++ +S+ ++ L + + + Q S+T R E A+E + L
Sbjct: 1281 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1340
Query: 404 GEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKG 463
E ALE++R ++ E + Q AQ E+ KELQ +R+ +E+ +E
Sbjct: 1341 AEVEAALEKQR-QLAEAHAQAKAQAEREAKELQ---------QRMQEEVVRREEAAVDAQ 1390
Query: 464 QEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQ-- 521
Q+ + LQ+L S E E+ R+ + + + +E+E+R + QL+ E Q
Sbjct: 1391 QQKRSIQEELQQL---RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1447
Query: 522 -----LAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLER--------LAGPPGPELPVAG 568
L + + E QK+Q ++ + L +QV + LA E A
Sbjct: 1448 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1507
Query: 569 EKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNV 628
EK AL +L+E + EE +R L++A+++ + + + E R A EL+ + +
Sbjct: 1508 EKQRAL----QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1563
Query: 629 VGRNQLLEGKLQALQADYQALQQ-RESAIQGSLASLEAEQASIRHLGDQMEASLLAVR-K 686
+ LE ++LQ ++ A+ Q RE A + + EAE+A ++ E L + K
Sbjct: 1564 AEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQAEAERAR-----EEAERELERWQLK 1615
Query: 687 AKEAMKAQMAEKEAILQSK--EGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLI 744
A EA++ ++ +E Q + E ++ +EE E+ EAR R E Q +Q +L
Sbjct: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER-----EARRR--GKAEEQAVRQRELA 1668
Query: 745 EVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQR--LQAQVVDLQAKMRAA 802
E ++ Q G + LAA+ L + + E QGE QR L+ ++ LQ + AA
Sbjct: 1669 EQELEKQRQLAEG----TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1724
Query: 803 LDDQDKVQSQLSMAEAVL-----------REHKTLVQQLKEQNEALNRAHVQELLQCSER 851
+ +++++L+ A + E ++ ++ K++ EA +EL + + R
Sbjct: 1725 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-EAGRFRELAEEAAR 1783
Query: 852 EGALQEE--------RADEAQQREEELRALQEEL------SQAKCSSEEAQLEHAELQEQ 897
AL EE D A+QR E R L E+L ++ K +E A E E+
Sbjct: 1784 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1843
Query: 898 LHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREG----LERQ--- 950
L R D A ++ R+EE A Q D +E ++ R+ LERQ
Sbjct: 1844 LRRLAEDEA----------FQRRRLEEQ---AAQHKADIEERLAQLRKASDSELERQKGL 1890
Query: 951 VAGLQQEKESLQEKLKAAKA----AAGSLPGLQAQLAQAEQRAQ-SLQEAAHQELNTLK- 1004
V +++ ++E++ A KA AA L+ +L + A+ +L+ EL +
Sbjct: 1891 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1950
Query: 1005 FQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKA------TQADMGE 1058
QL+AE + R + A E + EE RQ +AA E VE+LKA + E
Sbjct: 1951 RQLAAE---EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2007
Query: 1059 KLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRER 1118
+ S LA+ +AA R E A +++ ++EL++ + Q ++L E R
Sbjct: 2008 QESARQLQLAQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2066
Score = 142 bits (357), Expect = 3e-33
Identities = 212/904 (23%), Positives = 386/904 (42%), Gaps = 127/904 (14%)
Query: 241 QLEVREKQLRERMQQL----DRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVA 296
+LE ++R M+ L R +E R+ + ++L+ E R R AE+ RL L
Sbjct: 1730 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1789
Query: 297 ELQKQWEVTQ---ATQNTVKELQTCLQGLELGAAEK-EEDYHTALRRLES---MLQPLAQ 349
E ++Q ++ + A Q E + +G A + + + AL+ E+ L+ LA+
Sbjct: 1790 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1849
Query: 350 ELEATRDSLDKKN-QHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQ 408
+ R L+++ QH A LA ++ +D+ + RQ+ + D ++ +++ E++
Sbjct: 1850 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE---RQKGLVEDTLRQRRQVEEEIL 1906
Query: 409 ALERERTKVEEVNRQQSAQLEQLVKELQ--LKEDARASLERLVKEMAPLQEELSGKGQEA 466
AL+ K + +L ++ + L+ +A LE + +EE + +EA
Sbjct: 1907 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREA 1964
Query: 467 DQLWRRLQELLAHTSSWEEE----LAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQL 522
++ R+Q+ LA + L E+ R K + +E + L E+ + RQLQ +
Sbjct: 1965 EE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2021
Query: 523 -----AQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPV 577
A+ H +++++++L Q L Q+ +L++L G A E EA V
Sbjct: 2022 QKRLQAEEKAHAFAVQQKEQELQQT---LQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2078
Query: 578 NSSLQEAWGKPEEEQRGLQ----------EAQLDDTKVQEGSQEEELRQA---------- 617
++ + EE +R Q +AQ K+++ +++E R+A
Sbjct: 2079 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2138
Query: 618 ---NRELEKE---LQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIR 671
+ E+EK + + + +E +L L+ + +++ + L L+AE
Sbjct: 2139 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2198
Query: 672 HLGDQMEASLLAVRKAKEAMKAQMAEKEA-----ILQSKEGECQQLREEVEQCQQLAEAR 726
Q+E L +VR E + A EA IL+ K+ + L+EE E+ +Q+AE
Sbjct: 2199 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2258
Query: 727 HR---------ELRAL-ESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQA 776
R LR L E QQ L E + EK Q EA L A+ L Q
Sbjct: 2259 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ------AVQEATRLKAEAELLQQ 2312
Query: 777 QLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEA 836
Q E+ Q + +RLQ +DK Q +AE +TL + + Q E
Sbjct: 2313 QKELAQEQARRLQ----------------EDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2356
Query: 837 LNRAHVQELLQCSEREGALQEERADEAQQR-EEELRALQEELSQAKCSSEEAQLEHAELQ 895
A E L+ E + + RA+E QR ++ + E+L + + +++E L+
Sbjct: 2357 SAEA---ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2413
Query: 896 EQLHRANTDTAELGIQVCALTVEKERVEEALACA---------------VQELQDAKEAA 940
Q +++ D L + L EKE++++ +QE Q +++
Sbjct: 2414 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2473
Query: 941 SREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL-PGLQAQLAQAEQRAQ----SLQEA 995
E++ L ++ ++QEK L++ + A A L Q Q Q EQ Q S++EA
Sbjct: 2474 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2533
Query: 996 AHQ----ELNTLKFQLSAEIMDYQSRLKN--AGEECKSLRGQLEEQGRQLQAAEEAVEKL 1049
+ E + Q + ++ Q R + EE + LR QL+ Q +AA E++
Sbjct: 2534 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2593
Query: 1050 KATQ 1053
A+Q
Sbjct: 2594 TASQ 2597
Score = 129 bits (324), Expect = 2e-29
Identities = 207/880 (23%), Positives = 381/880 (43%), Gaps = 139/880 (15%)
Query: 385 TKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQ---LVKELQLKEDA 441
T G+ E + S +A +++L + + + R EEV R QL++ + L E
Sbjct: 1048 TLGKLEQVRSLSAIYLEKL-KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1106
Query: 442 RASLERLVKEMAP-------LQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREK 494
+ASL++L + L++EL G + ++L +R E W E +A+L
Sbjct: 1107 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1166
Query: 495 KQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQL----IQDKDHLSQQV 550
+ + ++ ++E+ L RQL++ + + D +++Q+ + D + +Q+
Sbjct: 1167 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1226
Query: 551 GMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDT------- 603
+ L E+ GEK E A K E Q +AQL+
Sbjct: 1227 RQEQALL----EEIERHGEKVEECQRFAKQYINAI-KDYELQLVTYKAQLEPVASPAKKP 1281
Query: 604 KVQEGSQE-----EELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQG 658
KVQ GS+ +LR EL + + + L+ ++ + + +Q+ + +
Sbjct: 1282 KVQSGSESVIQEYVDLRTHYSELTTLTSQYI---KFISETLRRMEEEERLAEQQRAEERE 1338
Query: 659 SLASLEAEQASIRHLGD-QMEASLLAVRKAKE---AMKAQMAEKEAILQSKEGECQQLRE 714
LA +EA R L + +A A R+AKE M+ ++ +E + + + ++E
Sbjct: 1339 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1398
Query: 715 EVEQCQQLAE----ARHRELRALES---QCQQQTQLIEV-LTAEKGQQGVGPPTDNEARE 766
E++Q +Q +E A+ R+ A E + +++ +++ + L A + Q+G + E +
Sbjct: 1399 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG---GAEGELQA 1455
Query: 767 LAAQLALSQAQLEVHQGEVQRLQAQVVD-LQAKMRAALDDQDKVQSQLSMAEAVLREHKT 825
L A+ ++AQ Q E +RL+ QV D Q K +A ++ +V+++ A RE +
Sbjct: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA----REKQR 1511
Query: 826 LVQQLKE-------------QNEALNRAHVQELLQCSER--EGALQEERADEAQQREEEL 870
+Q L+E Q E VQ L+ ++R E LQ +RA A++ +
Sbjct: 1512 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1571
Query: 871 RALQEE---LSQAKCSSEEAQLEHAELQEQLHRANTDTAELGI---QVCALTVEKERVEE 924
R+LQEE ++Q + +E + AE + A + + + L ++ E V +
Sbjct: 1572 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1631
Query: 925 ALACAVQELQDAKEAASRE--REGLERQVAGLQQE--KESLQEKLKAAK-------AAAG 973
+ A E + KE A RE R G + A Q+E ++ L+++ + A+ AA
Sbjct: 1632 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1691
Query: 974 SLPGLQAQLAQAEQRAQSLQE----------AAHQELNTLKFQLSAEIMDYQ-------- 1015
L L+A+ Q EQ+ Q L+E AA Q+ L+ +L+ + +
Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1751
Query: 1016 --------------------SRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKA-TQA 1054
R + EE LR EE RQ Q AEE + +A +
Sbjct: 1752 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1811
Query: 1055 DMGEKLSC---TSNHLAECQAAMLRKDKEGAALR-----EDLERTQKELEKATTK--IQE 1104
+ EKL+ + E + A+ K+ E LR E +R + E + A K I+E
Sbjct: 1812 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1871
Query: 1105 YYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIEL 1144
+L ++ ++ E QK L ++D R ++ +EE ++ L
Sbjct: 1872 RLAQL-RKASDSELERQKGL--VEDTLRQRRQVEEEILAL 1908
Score = 113 bits (282), Expect = 2e-24
Identities = 182/798 (22%), Positives = 328/798 (41%), Gaps = 88/798 (11%)
Query: 229 LEGFDEMRLELDQLEVREKQLRERMQQ---LDRENQELRAAVSQQGEQLQTERERGRTAA 285
LE + +L ++ E R ++ ER+Q+ + E R A ++ E+L+ + E R
Sbjct: 1945 LEAARQRQLAAEE-ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2003
Query: 286 EDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQ 345
E AE + ++ A + K LQ + +KE++ L++ +S+L
Sbjct: 2004 ER--------AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2055
Query: 346 PLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGE 405
L E EA R + ++ + A ++++ + A K +A+E +
Sbjct: 2056 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK--------QSAEEQAQARA 2107
Query: 406 KLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQE 465
+ QA + K E + AQ EQ L+ K+ A A +E+ K + + QE
Sbjct: 2108 QAQAAAEKLRKEAEQEAARRAQAEQAA--LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2165
Query: 466 ADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQV 525
L +L+E + +EEL L+ E + ++ +E+E+ S+ Q++ L A++
Sbjct: 2166 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2225
Query: 526 SQHVSDLEEQKKQLIQDKDH----LSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSL 581
E + +++DKD+ L ++ ++++A L VA ++ + L
Sbjct: 2226 EA------ENRALILRDKDNTQRFLQEEAEKMKQVA-EEAARLSVAAQEA-------ARL 2271
Query: 582 QEAWGKPEEEQRGLQEAQLDDTK--VQEGSQ---EEELRQANRELEKELQNVVGRN---- 632
++ + +QR L E L + VQE ++ E EL Q +EL +E + +
Sbjct: 2272 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2331
Query: 633 -QLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAM 691
Q L + Q Q +A +QR+ + L+ A + + E RK E +
Sbjct: 2332 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2391
Query: 692 KAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ---CQQQTQLIEVLT 748
++ E Q K Q L + +Q AE + LE + QQ+ +L+++ +
Sbjct: 2392 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2451
Query: 749 AE----KGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALD 804
E + +Q + + L+ + +L Q + + Q E +L+ D AK + +
Sbjct: 2452 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ-EKAKLEQLFQDEVAKAQQLRE 2510
Query: 805 DQDKVQSQL---------SMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
+Q + Q Q+ SM EA R+H E E + R QE LQ E++
Sbjct: 2511 EQQRQQQQMEQERQRLVASMEEARRRQH--------EAEEGVRRK--QEELQQLEQQRRQ 2560
Query: 856 QEER-ADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHR--------ANTDTA 906
QEE A+E Q+ E+L+ L+E+ A SEE + L A
Sbjct: 2561 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2620
Query: 907 ELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQ-VAGLQQEKESLQE-K 964
E V +R++EA + +ELQ + + E R+ V Q + S+
Sbjct: 2621 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2680
Query: 965 LKAAKAAAGSLPGLQAQL 982
LKA LQ QL
Sbjct: 2681 LKATNEKLSVYAALQRQL 2698
Score = 104 bits (260), Expect = 6e-22
Identities = 248/1151 (21%), Positives = 429/1151 (37%), Gaps = 256/1151 (22%)
Query: 230 EGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNV 289
E + + EL+ E + K+L+ +L RE+ R V LQT+ +
Sbjct: 634 ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSW-------ML 686
Query: 290 RLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEE-DYHTALRRLESMLQPLA 348
+L C + K+ + V+E + LQ L+ K D + RLE +LQ
Sbjct: 687 QLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQ--- 743
Query: 349 QELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQ 408
D+ D+K Q L + G L+ ++A K P A M+ L
Sbjct: 744 -------DAQDEKEQ-LNEYKGHLSGLAKRAKAVVQLK------PRHPAHPMRGRLPLLA 789
Query: 409 ALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMA-----PLQE------ 457
+ ++ +V V++ QL + K + + E V + P QE
Sbjct: 790 VCDYKQVEV-TVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVT 848
Query: 458 ELSGKGQEADQLWRRLQELLAHTSSWEE-----------ELAELRREKKQQQ-------- 498
L + Q LW +L + +W+ LA R K ++Q
Sbjct: 849 RLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE 908
Query: 499 ------------------EEKELLEQEVRSLTRQLQFLETQLAQVSQH-------VSDLE 533
E++ + E+E S + Q L L Q +Q +S+L+
Sbjct: 909 LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 968
Query: 534 EQKKQLIQDKDHLSQQVGM----------LERLAGPPGPELPVAG--------------- 568
+ + QL + ++ + +R+A + V G
Sbjct: 969 DIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKV 1028
Query: 569 ----EKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTK----VQEGSQ-EEELRQANR 619
E + A + S L+ GK E+ R L L+ K V G+Q EE+ +A+
Sbjct: 1029 LALPEPSPAAPTLRSELELTLGK-LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE 1087
Query: 620 ELEKELQNVVGRNQLLE---GKLQALQADYQA---------------------LQQRE-- 653
E KE Q V LE L+ L+A +A LQQR
Sbjct: 1088 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1147
Query: 654 ----------------SAIQGSLASLEAEQASIRHLG----------DQMEASLLAVRKA 687
Q LA + Q + LG D + A L R+
Sbjct: 1148 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1207
Query: 688 KE-----------AMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ 736
+E A++ Q+ +++A+L+ E ++ E+VE+CQ+ A+ ++ E
Sbjct: 1208 QEQIQAMPLADSQAVREQLRQEQALLE----EIERHGEKVEECQRFAKQYINAIKDYE-- 1261
Query: 737 CQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQ-AQLEVHQGEVQRLQAQVVDL 795
++++T + + V P + ++ + + L H E+ L +Q +
Sbjct: 1262 -------LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1314
Query: 796 QAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
++ +++++++ Q E RE V+ E+ L AH Q Q L
Sbjct: 1315 ISETLRRMEEEERLAEQQRAEE---RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1371
Query: 856 QEERADEAQQREE-------ELRALQEELSQAKCSSE---EAQLEHAELQEQLH-RANTD 904
Q+ +E +REE + R++QEEL Q + SSE +A+ AE E+ R +
Sbjct: 1372 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1431
Query: 905 TAELGIQVCALTVEKERVE---EALACAVQELQDAKEAASREREGLERQVAGLQQEKESL 961
+ +Q+ A ++ E +AL +E + K A E E L RQV Q K
Sbjct: 1432 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1491
Query: 962 QEKL--------KAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKF-----QLS 1008
+ +L +AA+ +L L+ QAE+ + L++A + ++ Q S
Sbjct: 1492 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1551
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQLEE------------------QGRQLQAAEEAVEKLK 1050
AE + QS+ + E+ L L+E Q +A EEA +L+
Sbjct: 1552 AE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1610
Query: 1051 ATQADMGEKLS--------CTSNHLAECQAAMLRKDKEGAALR----EDLERTQKEL-EK 1097
Q E L LA+ +A +++ E A R E+ Q+EL E+
Sbjct: 1611 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1670
Query: 1098 ATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDA 1157
K ++ Q+ E+ ++ A+ + + ++ LEE L L R+ A QK
Sbjct: 1671 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1730
Query: 1158 LEFQ-QKLSAE 1167
LE + K+ AE
Sbjct: 1731 LEAELAKVRAE 1741
Score = 49.3 bits (116), Expect = 3e-05
Identities = 73/345 (21%), Positives = 147/345 (42%), Gaps = 24/345 (6%)
Query: 865 QREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRAN----TDTAELG---IQVCALTV 917
+RE++LR+ E L + + Q+E +EQL++A+ +D L + A V
Sbjct: 357 EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEV 416
Query: 918 EK--ERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL 975
E+ ++ + + ++Q K+ + E + R+V L + +++ + A +
Sbjct: 417 ERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAA 476
Query: 976 PGLQAQLAQAEQRAQSLQEAAHQELNTLKF--QLSAEIMDYQSRLKNA--GEECKSLRGQ 1031
P Q A+ QS+Q E +TL++ L A + + Q R+ A G + S+ Q
Sbjct: 477 PATQV----AQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ 532
Query: 1032 LEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERT 1091
L Q+ EE K++ ++D G+ T +C + R D + A L +
Sbjct: 533 LGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDC---LGRLDLQYAKLLNSSKAR 589
Query: 1092 QKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDAL 1151
+ LE + + +L + E+ ++++ D D N +E L+R+ +
Sbjct: 590 LRSLESLHSFVAAATKEL---MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 646
Query: 1152 WQKSDALE-FQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHC 1195
+K L+ +L E+ T + + ++SWM++ C
Sbjct: 647 EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCC 691
Score = 42.7 bits (99), Expect = 0.003
Identities = 56/242 (23%), Positives = 92/242 (38%), Gaps = 27/242 (11%)
Query: 197 RSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQL 256
+ + + L S +QT + L L D + +E + +L + Q
Sbjct: 2442 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2501
Query: 257 DRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQ 316
+ Q+LR +Q +Q++ ER+R LVA +++ + V+ Q
Sbjct: 2502 VAKAQQLREEQQRQQQQMEQERQR-------------LVASMEEARRRQHEAEEGVRRKQ 2548
Query: 317 TCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQ 376
LQ LE ++EE +RL LQ L E R +L + AS
Sbjct: 2549 EELQQLEQQRRQQEELLAEENQRLREQLQLLE---EQHRAALAHSEEVTASQVAATKTLP 2605
Query: 377 QKADTASDTKGRQEPIPS-------DAAQEMQELG----EKLQALERERTKVEEVNRQQS 425
D EP S +AQ +QE G E+LQ L + T V+E+ R++
Sbjct: 2606 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2665
Query: 426 AQ 427
+
Sbjct: 2666 VR 2667
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 162 bits (411), Expect = 2e-39
Identities = 240/1006 (23%), Positives = 425/1006 (42%), Gaps = 114/1006 (11%)
Query: 241 QLEVREKQLRERMQQLDRENQELRAAVSQQGE------QLQTERERGRTAAE-------- 286
+L+ + E+ QL+R QE AV+Q E Q Q E ER R AE
Sbjct: 1563 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1622
Query: 287 ---DNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESM 343
+ +RL E+ +Q + QA KE + + G AE++ L E
Sbjct: 1623 KANEALRLRLQAEEVAQQKSLAQAEAEKQKE-EAEREARRRGKAEEQAVRQRELAEQE-- 1679
Query: 344 LQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQEL 403
L+ Q E T Q L +Q+ + R + + A Q+ QEL
Sbjct: 1680 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1739
Query: 404 GEKLQALERE-------RTKVEEVNRQQSAQLEQLVKE-----LQLKEDA---RASLERL 448
+L + E + + EE +R S + +Q ++ +L E+A RA E
Sbjct: 1740 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1799
Query: 449 VKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEV 508
++ +E+ + + EA+++ L E LA E L+ E + +EKE + +
Sbjct: 1800 KRQRQLAEEDAARQRAEAERV---LAEKLAAIG----EATRLKTEAEIALKEKEAENERL 1852
Query: 509 RSLTRQLQFLETQLA-QVSQHVSDLEEQKKQLIQDKD-HLSQQVGMLE---RLAGPPGPE 563
R L F +L Q +QH +D+EE+ QL + D L +Q G++E R E
Sbjct: 1853 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1912
Query: 564 LPVAGEKNEALVPVNSSLQEAWGK----PEEEQRGLQEAQLDDTKVQEGSQEEELRQANR 619
+ E + L+ G+ E+ R ++A+L+ + ++ + EEE R+ R
Sbjct: 1913 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 1970
Query: 620 ELEKELQNVVG--------RNQLLEGKLQALQADYQ-ALQQRESAIQGSLASLE-AEQAS 669
E E+ +Q + R LE +++ L+A + A + RE A Q S L+ A++A+
Sbjct: 1971 EAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2029
Query: 670 IRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRE 729
+ L + +A AV++ ++ ++ + +++++L GE + R E+ ++ RE
Sbjct: 2030 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2089
Query: 730 LRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQ 789
Q ++ +L + +AE+ Q AQ A + + E Q +R Q
Sbjct: 2090 AAQSRRQVEEAERLKQ--SAEEQAQA----------RAQAQAAAEKLRKEAEQEAARRAQ 2137
Query: 790 AQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCS 849
A+ L+ K A + ++ AE LR+ + Q+L L Q+ L
Sbjct: 2138 AEQAALRQKQAADAE----MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2193
Query: 850 EREGALQEERADEAQQR---EEEL---RALQEELSQAKCSSE------------EAQLEH 891
E + L+ E + A+QR EEEL R EELS+ K E Q
Sbjct: 2194 ELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2252
Query: 892 AELQEQLHRANTDTAELGIQVCALTVEKERVEEALA---CAVQELQDAKEAASREREGLE 948
E E++ + + A L + ++ EE LA +++ K A +E L+
Sbjct: 2253 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2312
Query: 949 RQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLS 1008
+ LQQ+KE QE+ + + + A+ Q QR + E++ +L
Sbjct: 2313 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2372
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLA 1068
+ + A E+ + R Q EE G +L E A ++ K T E S+H A
Sbjct: 2373 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDA 2431
Query: 1069 E-CQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADL 1127
E + A+ ++E L+++ + Q + E+ T QE +L QE + Q L++
Sbjct: 2432 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---QLLQET---QALQQSFLSEK 2485
Query: 1128 DDLNRTKKYLEE---RLIELLRDKDALWQK-SDALEFQQKLSAEER 1169
D L + ++++E+ +L +L +D+ A Q+ + + QQ+ +ER
Sbjct: 2486 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER 2531
Score = 157 bits (397), Expect = 7e-38
Identities = 245/1020 (24%), Positives = 438/1020 (42%), Gaps = 150/1020 (14%)
Query: 195 PSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQ 254
P ++ +SL Q + FD A E + ++ + +V ++ RER+
Sbjct: 1109 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1168
Query: 255 QLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEV--------TQ 306
QL Q + A + +L+ + R E L + + +++ E +Q
Sbjct: 1169 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1228
Query: 307 ATQNTVKELQTCLQGLELGAAEKEE-------------DYHTALRRLESMLQPLAQ---- 349
A + +++ Q L+ +E + EE DY L ++ L+P+A
Sbjct: 1229 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1288
Query: 350 -ELEATRDSLDKKNQHLAS-FPGWLAMAQQKADTASDTKGRQEP----IPSDAAQEMQEL 403
++++ +S+ ++ L + + + Q S+T R E A+E + L
Sbjct: 1289 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1348
Query: 404 GEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKG 463
E ALE++R ++ E + Q AQ E+ KELQ +R+ +E+ +E
Sbjct: 1349 AEVEAALEKQR-QLAEAHAQAKAQAEREAKELQ---------QRMQEEVVRREEAAVDAQ 1398
Query: 464 QEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQ-- 521
Q+ + LQ+L S E E+ R+ + + + +E+E+R + QL+ E Q
Sbjct: 1399 QQKRSIQEELQQL---RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1455
Query: 522 -----LAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLER--------LAGPPGPELPVAG 568
L + + E QK+Q ++ + L +QV + LA E A
Sbjct: 1456 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1515
Query: 569 EKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNV 628
EK AL +L+E + EE +R L++A+++ + + + E R A EL+ + +
Sbjct: 1516 EKQRAL----QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1571
Query: 629 VGRNQLLEGKLQALQADYQALQQ-RESAIQGSLASLEAEQASIRHLGDQMEASLLAVR-K 686
+ LE ++LQ ++ A+ Q RE A + + EAE+A ++ E L + K
Sbjct: 1572 AEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQAEAERAR-----EEAERELERWQLK 1623
Query: 687 AKEAMKAQMAEKEAILQSK--EGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLI 744
A EA++ ++ +E Q + E ++ +EE E+ EAR R E Q +Q +L
Sbjct: 1624 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER-----EARRR--GKAEEQAVRQRELA 1676
Query: 745 EVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQR--LQAQVVDLQAKMRAA 802
E ++ Q G + LAA+ L + + E QGE QR L+ ++ LQ + AA
Sbjct: 1677 EQELEKQRQLAEG----TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1732
Query: 803 LDDQDKVQSQLSMAEAVL-----------REHKTLVQQLKEQNEALNRAHVQELLQCSER 851
+ +++++L+ A + E ++ ++ K++ EA +EL + + R
Sbjct: 1733 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-EAGRFRELAEEAAR 1791
Query: 852 EGALQEE--------RADEAQQREEELRALQEEL------SQAKCSSEEAQLEHAELQEQ 897
AL EE D A+QR E R L E+L ++ K +E A E E+
Sbjct: 1792 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1851
Query: 898 LHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREG----LERQ--- 950
L R D A ++ R+EE A Q D +E ++ R+ LERQ
Sbjct: 1852 LRRLAEDEA----------FQRRRLEEQ---AAQHKADIEERLAQLRKASDSELERQKGL 1898
Query: 951 VAGLQQEKESLQEKLKAAKA----AAGSLPGLQAQLAQAEQRAQ-SLQEAAHQELNTLK- 1004
V +++ ++E++ A KA AA L+ +L + A+ +L+ EL +
Sbjct: 1899 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1958
Query: 1005 FQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKA------TQADMGE 1058
QL+AE + R + A E + EE RQ +AA E VE+LKA + E
Sbjct: 1959 RQLAAE---EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2015
Query: 1059 KLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRER 1118
+ S LA+ +AA R E A +++ ++EL++ + Q ++L E R
Sbjct: 2016 QESARQLQLAQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2074
Score = 142 bits (357), Expect = 3e-33
Identities = 212/904 (23%), Positives = 386/904 (42%), Gaps = 127/904 (14%)
Query: 241 QLEVREKQLRERMQQL----DRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVA 296
+LE ++R M+ L R +E R+ + ++L+ E R R AE+ RL L
Sbjct: 1738 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1797
Query: 297 ELQKQWEVTQ---ATQNTVKELQTCLQGLELGAAEK-EEDYHTALRRLES---MLQPLAQ 349
E ++Q ++ + A Q E + +G A + + + AL+ E+ L+ LA+
Sbjct: 1798 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1857
Query: 350 ELEATRDSLDKKN-QHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQ 408
+ R L+++ QH A LA ++ +D+ + RQ+ + D ++ +++ E++
Sbjct: 1858 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE---RQKGLVEDTLRQRRQVEEEIL 1914
Query: 409 ALERERTKVEEVNRQQSAQLEQLVKELQ--LKEDARASLERLVKEMAPLQEELSGKGQEA 466
AL+ K + +L ++ + L+ +A LE + +EE + +EA
Sbjct: 1915 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREA 1972
Query: 467 DQLWRRLQELLAHTSSWEEE----LAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQL 522
++ R+Q+ LA + L E+ R K + +E + L E+ + RQLQ +
Sbjct: 1973 EE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2029
Query: 523 -----AQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPV 577
A+ H +++++++L Q L Q+ +L++L G A E EA V
Sbjct: 2030 QKRLQAEEKAHAFAVQQKEQELQQT---LQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2086
Query: 578 NSSLQEAWGKPEEEQRGLQ----------EAQLDDTKVQEGSQEEELRQA---------- 617
++ + EE +R Q +AQ K+++ +++E R+A
Sbjct: 2087 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2146
Query: 618 ---NRELEKE---LQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIR 671
+ E+EK + + + +E +L L+ + +++ + L L+AE
Sbjct: 2147 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2206
Query: 672 HLGDQMEASLLAVRKAKEAMKAQMAEKEA-----ILQSKEGECQQLREEVEQCQQLAEAR 726
Q+E L +VR E + A EA IL+ K+ + L+EE E+ +Q+AE
Sbjct: 2207 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2266
Query: 727 HR---------ELRAL-ESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQA 776
R LR L E QQ L E + EK Q EA L A+ L Q
Sbjct: 2267 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ------AVQEATRLKAEAELLQQ 2320
Query: 777 QLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEA 836
Q E+ Q + +RLQ +DK Q +AE +TL + + Q E
Sbjct: 2321 QKELAQEQARRLQ----------------EDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2364
Query: 837 LNRAHVQELLQCSEREGALQEERADEAQQR-EEELRALQEELSQAKCSSEEAQLEHAELQ 895
A E L+ E + + RA+E QR ++ + E+L + + +++E L+
Sbjct: 2365 SAEA---ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2421
Query: 896 EQLHRANTDTAELGIQVCALTVEKERVEEALACA---------------VQELQDAKEAA 940
Q +++ D L + L EKE++++ +QE Q +++
Sbjct: 2422 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2481
Query: 941 SREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL-PGLQAQLAQAEQRAQ----SLQEA 995
E++ L ++ ++QEK L++ + A A L Q Q Q EQ Q S++EA
Sbjct: 2482 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2541
Query: 996 AHQ----ELNTLKFQLSAEIMDYQSRLKN--AGEECKSLRGQLEEQGRQLQAAEEAVEKL 1049
+ E + Q + ++ Q R + EE + LR QL+ Q +AA E++
Sbjct: 2542 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2601
Query: 1050 KATQ 1053
A+Q
Sbjct: 2602 TASQ 2605
Score = 129 bits (324), Expect = 2e-29
Identities = 207/880 (23%), Positives = 381/880 (43%), Gaps = 139/880 (15%)
Query: 385 TKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQ---LVKELQLKEDA 441
T G+ E + S +A +++L + + + R EEV R QL++ + L E
Sbjct: 1056 TLGKLEQVRSLSAIYLEKL-KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1114
Query: 442 RASLERLVKEMAP-------LQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREK 494
+ASL++L + L++EL G + ++L +R E W E +A+L
Sbjct: 1115 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1174
Query: 495 KQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQL----IQDKDHLSQQV 550
+ + ++ ++E+ L RQL++ + + D +++Q+ + D + +Q+
Sbjct: 1175 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1234
Query: 551 GMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDT------- 603
+ L E+ GEK E A K E Q +AQL+
Sbjct: 1235 RQEQALL----EEIERHGEKVEECQRFAKQYINAI-KDYELQLVTYKAQLEPVASPAKKP 1289
Query: 604 KVQEGSQE-----EELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQG 658
KVQ GS+ +LR EL + + + L+ ++ + + +Q+ + +
Sbjct: 1290 KVQSGSESVIQEYVDLRTHYSELTTLTSQYI---KFISETLRRMEEEERLAEQQRAEERE 1346
Query: 659 SLASLEAEQASIRHLGD-QMEASLLAVRKAKE---AMKAQMAEKEAILQSKEGECQQLRE 714
LA +EA R L + +A A R+AKE M+ ++ +E + + + ++E
Sbjct: 1347 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1406
Query: 715 EVEQCQQLAE----ARHRELRALES---QCQQQTQLIEV-LTAEKGQQGVGPPTDNEARE 766
E++Q +Q +E A+ R+ A E + +++ +++ + L A + Q+G + E +
Sbjct: 1407 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG---GAEGELQA 1463
Query: 767 LAAQLALSQAQLEVHQGEVQRLQAQVVD-LQAKMRAALDDQDKVQSQLSMAEAVLREHKT 825
L A+ ++AQ Q E +RL+ QV D Q K +A ++ +V+++ A RE +
Sbjct: 1464 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA----REKQR 1519
Query: 826 LVQQLKE-------------QNEALNRAHVQELLQCSER--EGALQEERADEAQQREEEL 870
+Q L+E Q E VQ L+ ++R E LQ +RA A++ +
Sbjct: 1520 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1579
Query: 871 RALQEE---LSQAKCSSEEAQLEHAELQEQLHRANTDTAELGI---QVCALTVEKERVEE 924
R+LQEE ++Q + +E + AE + A + + + L ++ E V +
Sbjct: 1580 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1639
Query: 925 ALACAVQELQDAKEAASRE--REGLERQVAGLQQE--KESLQEKLKAAK-------AAAG 973
+ A E + KE A RE R G + A Q+E ++ L+++ + A+ AA
Sbjct: 1640 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1699
Query: 974 SLPGLQAQLAQAEQRAQSLQE----------AAHQELNTLKFQLSAEIMDYQ-------- 1015
L L+A+ Q EQ+ Q L+E AA Q+ L+ +L+ + +
Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1759
Query: 1016 --------------------SRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKA-TQA 1054
R + EE LR EE RQ Q AEE + +A +
Sbjct: 1760 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1819
Query: 1055 DMGEKLSC---TSNHLAECQAAMLRKDKEGAALR-----EDLERTQKELEKATTK--IQE 1104
+ EKL+ + E + A+ K+ E LR E +R + E + A K I+E
Sbjct: 1820 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1879
Query: 1105 YYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIEL 1144
+L ++ ++ E QK L ++D R ++ +EE ++ L
Sbjct: 1880 RLAQL-RKASDSELERQKGL--VEDTLRQRRQVEEEILAL 1916
Score = 113 bits (282), Expect = 2e-24
Identities = 182/798 (22%), Positives = 328/798 (41%), Gaps = 88/798 (11%)
Query: 229 LEGFDEMRLELDQLEVREKQLRERMQQ---LDRENQELRAAVSQQGEQLQTERERGRTAA 285
LE + +L ++ E R ++ ER+Q+ + E R A ++ E+L+ + E R
Sbjct: 1953 LEAARQRQLAAEE-ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2011
Query: 286 EDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQ 345
E AE + ++ A + K LQ + +KE++ L++ +S+L
Sbjct: 2012 ER--------AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2063
Query: 346 PLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGE 405
L E EA R + ++ + A ++++ + A K +A+E +
Sbjct: 2064 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK--------QSAEEQAQARA 2115
Query: 406 KLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQE 465
+ QA + K E + AQ EQ L+ K+ A A +E+ K + + QE
Sbjct: 2116 QAQAAAEKLRKEAEQEAARRAQAEQAA--LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2173
Query: 466 ADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQV 525
L +L+E + +EEL L+ E + ++ +E+E+ S+ Q++ L A++
Sbjct: 2174 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2233
Query: 526 SQHVSDLEEQKKQLIQDKDH----LSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSL 581
E + +++DKD+ L ++ ++++A L VA ++ + L
Sbjct: 2234 EA------ENRALILRDKDNTQRFLQEEAEKMKQVA-EEAARLSVAAQEA-------ARL 2279
Query: 582 QEAWGKPEEEQRGLQEAQLDDTK--VQEGSQ---EEELRQANRELEKELQNVVGRN---- 632
++ + +QR L E L + VQE ++ E EL Q +EL +E + +
Sbjct: 2280 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2339
Query: 633 -QLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAM 691
Q L + Q Q +A +QR+ + L+ A + + E RK E +
Sbjct: 2340 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2399
Query: 692 KAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ---CQQQTQLIEVLT 748
++ E Q K Q L + +Q AE + LE + QQ+ +L+++ +
Sbjct: 2400 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2459
Query: 749 AE----KGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALD 804
E + +Q + + L+ + +L Q + + Q E +L+ D AK + +
Sbjct: 2460 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ-EKAKLEQLFQDEVAKAQQLRE 2518
Query: 805 DQDKVQSQL---------SMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
+Q + Q Q+ SM EA R+H E E + R QE LQ E++
Sbjct: 2519 EQQRQQQQMEQERQRLVASMEEARRRQH--------EAEEGVRRK--QEELQQLEQQRRQ 2568
Query: 856 QEER-ADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHR--------ANTDTA 906
QEE A+E Q+ E+L+ L+E+ A SEE + L A
Sbjct: 2569 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2628
Query: 907 ELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQ-VAGLQQEKESLQE-K 964
E V +R++EA + +ELQ + + E R+ V Q + S+
Sbjct: 2629 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2688
Query: 965 LKAAKAAAGSLPGLQAQL 982
LKA LQ QL
Sbjct: 2689 LKATNEKLSVYAALQRQL 2706
Score = 104 bits (260), Expect = 6e-22
Identities = 248/1151 (21%), Positives = 429/1151 (37%), Gaps = 256/1151 (22%)
Query: 230 EGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNV 289
E + + EL+ E + K+L+ +L RE+ R V LQT+ +
Sbjct: 642 ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSW-------ML 694
Query: 290 RLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEE-DYHTALRRLESMLQPLA 348
+L C + K+ + V+E + LQ L+ K D + RLE +LQ
Sbjct: 695 QLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQ--- 751
Query: 349 QELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQ 408
D+ D+K Q L + G L+ ++A K P A M+ L
Sbjct: 752 -------DAQDEKEQ-LNEYKGHLSGLAKRAKAVVQLK------PRHPAHPMRGRLPLLA 797
Query: 409 ALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMA-----PLQE------ 457
+ ++ +V V++ QL + K + + E V + P QE
Sbjct: 798 VCDYKQVEV-TVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVT 856
Query: 458 ELSGKGQEADQLWRRLQELLAHTSSWEE-----------ELAELRREKKQQQ-------- 498
L + Q LW +L + +W+ LA R K ++Q
Sbjct: 857 RLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE 916
Query: 499 ------------------EEKELLEQEVRSLTRQLQFLETQLAQVSQH-------VSDLE 533
E++ + E+E S + Q L L Q +Q +S+L+
Sbjct: 917 LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 976
Query: 534 EQKKQLIQDKDHLSQQVGM----------LERLAGPPGPELPVAG--------------- 568
+ + QL + ++ + +R+A + V G
Sbjct: 977 DIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKV 1036
Query: 569 ----EKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTK----VQEGSQ-EEELRQANR 619
E + A + S L+ GK E+ R L L+ K V G+Q EE+ +A+
Sbjct: 1037 LALPEPSPAAPTLRSELELTLGK-LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE 1095
Query: 620 ELEKELQNVVGRNQLLE---GKLQALQADYQA---------------------LQQRE-- 653
E KE Q V LE L+ L+A +A LQQR
Sbjct: 1096 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1155
Query: 654 ----------------SAIQGSLASLEAEQASIRHLG----------DQMEASLLAVRKA 687
Q LA + Q + LG D + A L R+
Sbjct: 1156 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1215
Query: 688 KE-----------AMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ 736
+E A++ Q+ +++A+L+ E ++ E+VE+CQ+ A+ ++ E
Sbjct: 1216 QEQIQAMPLADSQAVREQLRQEQALLE----EIERHGEKVEECQRFAKQYINAIKDYE-- 1269
Query: 737 CQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQ-AQLEVHQGEVQRLQAQVVDL 795
++++T + + V P + ++ + + L H E+ L +Q +
Sbjct: 1270 -------LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1322
Query: 796 QAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
++ +++++++ Q E RE V+ E+ L AH Q Q L
Sbjct: 1323 ISETLRRMEEEERLAEQQRAEE---RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1379
Query: 856 QEERADEAQQREE-------ELRALQEELSQAKCSSE---EAQLEHAELQEQLH-RANTD 904
Q+ +E +REE + R++QEEL Q + SSE +A+ AE E+ R +
Sbjct: 1380 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1439
Query: 905 TAELGIQVCALTVEKERVE---EALACAVQELQDAKEAASREREGLERQVAGLQQEKESL 961
+ +Q+ A ++ E +AL +E + K A E E L RQV Q K
Sbjct: 1440 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1499
Query: 962 QEKL--------KAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKF-----QLS 1008
+ +L +AA+ +L L+ QAE+ + L++A + ++ Q S
Sbjct: 1500 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1559
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQLEE------------------QGRQLQAAEEAVEKLK 1050
AE + QS+ + E+ L L+E Q +A EEA +L+
Sbjct: 1560 AE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1618
Query: 1051 ATQADMGEKLS--------CTSNHLAECQAAMLRKDKEGAALR----EDLERTQKEL-EK 1097
Q E L LA+ +A +++ E A R E+ Q+EL E+
Sbjct: 1619 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1678
Query: 1098 ATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDA 1157
K ++ Q+ E+ ++ A+ + + ++ LEE L L R+ A QK
Sbjct: 1679 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1738
Query: 1158 LEFQ-QKLSAE 1167
LE + K+ AE
Sbjct: 1739 LEAELAKVRAE 1749
Score = 49.3 bits (116), Expect = 3e-05
Identities = 73/345 (21%), Positives = 147/345 (42%), Gaps = 24/345 (6%)
Query: 865 QREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRAN----TDTAELG---IQVCALTV 917
+RE++LR+ E L + + Q+E +EQL++A+ +D L + A V
Sbjct: 365 EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEV 424
Query: 918 EK--ERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL 975
E+ ++ + + ++Q K+ + E + R+V L + +++ + A +
Sbjct: 425 ERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAA 484
Query: 976 PGLQAQLAQAEQRAQSLQEAAHQELNTLKF--QLSAEIMDYQSRLKNA--GEECKSLRGQ 1031
P Q A+ QS+Q E +TL++ L A + + Q R+ A G + S+ Q
Sbjct: 485 PATQV----AQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ 540
Query: 1032 LEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERT 1091
L Q+ EE K++ ++D G+ T +C + R D + A L +
Sbjct: 541 LGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDC---LGRLDLQYAKLLNSSKAR 597
Query: 1092 QKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDAL 1151
+ LE + + +L + E+ ++++ D D N +E L+R+ +
Sbjct: 598 LRSLESLHSFVAAATKEL---MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 654
Query: 1152 WQKSDALE-FQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHC 1195
+K L+ +L E+ T + + ++SWM++ C
Sbjct: 655 EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCC 699
Score = 42.7 bits (99), Expect = 0.003
Identities = 56/242 (23%), Positives = 92/242 (38%), Gaps = 27/242 (11%)
Query: 197 RSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQL 256
+ + + L S +QT + L L D + +E + +L + Q
Sbjct: 2450 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2509
Query: 257 DRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQ 316
+ Q+LR +Q +Q++ ER+R LVA +++ + V+ Q
Sbjct: 2510 VAKAQQLREEQQRQQQQMEQERQR-------------LVASMEEARRRQHEAEEGVRRKQ 2556
Query: 317 TCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQ 376
LQ LE ++EE +RL LQ L E R +L + AS
Sbjct: 2557 EELQQLEQQRRQQEELLAEENQRLREQLQLLE---EQHRAALAHSEEVTASQVAATKTLP 2613
Query: 377 QKADTASDTKGRQEPIPS-------DAAQEMQELG----EKLQALERERTKVEEVNRQQS 425
D EP S +AQ +QE G E+LQ L + T V+E+ R++
Sbjct: 2614 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2673
Query: 426 AQ 427
+
Sbjct: 2674 VR 2675
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 162 bits (411), Expect = 2e-39
Identities = 240/1006 (23%), Positives = 425/1006 (42%), Gaps = 114/1006 (11%)
Query: 241 QLEVREKQLRERMQQLDRENQELRAAVSQQGE------QLQTERERGRTAAE-------- 286
+L+ + E+ QL+R QE AV+Q E Q Q E ER R AE
Sbjct: 1604 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1663
Query: 287 ---DNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESM 343
+ +RL E+ +Q + QA KE + + G AE++ L E
Sbjct: 1664 KANEALRLRLQAEEVAQQKSLAQAEAEKQKE-EAEREARRRGKAEEQAVRQRELAEQE-- 1720
Query: 344 LQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQEL 403
L+ Q E T Q L +Q+ + R + + A Q+ QEL
Sbjct: 1721 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1780
Query: 404 GEKLQALERE-------RTKVEEVNRQQSAQLEQLVKE-----LQLKEDA---RASLERL 448
+L + E + + EE +R S + +Q ++ +L E+A RA E
Sbjct: 1781 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1840
Query: 449 VKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEV 508
++ +E+ + + EA+++ L E LA E L+ E + +EKE + +
Sbjct: 1841 KRQRQLAEEDAARQRAEAERV---LAEKLAAIG----EATRLKTEAEIALKEKEAENERL 1893
Query: 509 RSLTRQLQFLETQLA-QVSQHVSDLEEQKKQLIQDKD-HLSQQVGMLE---RLAGPPGPE 563
R L F +L Q +QH +D+EE+ QL + D L +Q G++E R E
Sbjct: 1894 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1953
Query: 564 LPVAGEKNEALVPVNSSLQEAWGK----PEEEQRGLQEAQLDDTKVQEGSQEEELRQANR 619
+ E + L+ G+ E+ R ++A+L+ + ++ + EEE R+ R
Sbjct: 1954 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 2011
Query: 620 ELEKELQNVVG--------RNQLLEGKLQALQADYQ-ALQQRESAIQGSLASLE-AEQAS 669
E E+ +Q + R LE +++ L+A + A + RE A Q S L+ A++A+
Sbjct: 2012 EAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2070
Query: 670 IRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRE 729
+ L + +A AV++ ++ ++ + +++++L GE + R E+ ++ RE
Sbjct: 2071 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2130
Query: 730 LRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQ 789
Q ++ +L + +AE+ Q AQ A + + E Q +R Q
Sbjct: 2131 AAQSRRQVEEAERLKQ--SAEEQAQA----------RAQAQAAAEKLRKEAEQEAARRAQ 2178
Query: 790 AQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCS 849
A+ L+ K A + ++ AE LR+ + Q+L L Q+ L
Sbjct: 2179 AEQAALRQKQAADAE----MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2234
Query: 850 EREGALQEERADEAQQR---EEEL---RALQEELSQAKCSSE------------EAQLEH 891
E + L+ E + A+QR EEEL R EELS+ K E Q
Sbjct: 2235 ELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2293
Query: 892 AELQEQLHRANTDTAELGIQVCALTVEKERVEEALA---CAVQELQDAKEAASREREGLE 948
E E++ + + A L + ++ EE LA +++ K A +E L+
Sbjct: 2294 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2353
Query: 949 RQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLS 1008
+ LQQ+KE QE+ + + + A+ Q QR + E++ +L
Sbjct: 2354 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2413
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLA 1068
+ + A E+ + R Q EE G +L E A ++ K T E S+H A
Sbjct: 2414 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDA 2472
Query: 1069 E-CQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADL 1127
E + A+ ++E L+++ + Q + E+ T QE +L QE + Q L++
Sbjct: 2473 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---QLLQET---QALQQSFLSEK 2526
Query: 1128 DDLNRTKKYLEE---RLIELLRDKDALWQK-SDALEFQQKLSAEER 1169
D L + ++++E+ +L +L +D+ A Q+ + + QQ+ +ER
Sbjct: 2527 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER 2572
Score = 157 bits (397), Expect = 7e-38
Identities = 245/1020 (24%), Positives = 438/1020 (42%), Gaps = 150/1020 (14%)
Query: 195 PSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQ 254
P ++ +SL Q + FD A E + ++ + +V ++ RER+
Sbjct: 1150 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1209
Query: 255 QLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEV--------TQ 306
QL Q + A + +L+ + R E L + + +++ E +Q
Sbjct: 1210 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1269
Query: 307 ATQNTVKELQTCLQGLELGAAEKEE-------------DYHTALRRLESMLQPLAQ---- 349
A + +++ Q L+ +E + EE DY L ++ L+P+A
Sbjct: 1270 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1329
Query: 350 -ELEATRDSLDKKNQHLAS-FPGWLAMAQQKADTASDTKGRQEP----IPSDAAQEMQEL 403
++++ +S+ ++ L + + + Q S+T R E A+E + L
Sbjct: 1330 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1389
Query: 404 GEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKG 463
E ALE++R ++ E + Q AQ E+ KELQ +R+ +E+ +E
Sbjct: 1390 AEVEAALEKQR-QLAEAHAQAKAQAEREAKELQ---------QRMQEEVVRREEAAVDAQ 1439
Query: 464 QEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQ-- 521
Q+ + LQ+L S E E+ R+ + + + +E+E+R + QL+ E Q
Sbjct: 1440 QQKRSIQEELQQL---RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1496
Query: 522 -----LAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLER--------LAGPPGPELPVAG 568
L + + E QK+Q ++ + L +QV + LA E A
Sbjct: 1497 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1556
Query: 569 EKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNV 628
EK AL +L+E + EE +R L++A+++ + + + E R A EL+ + +
Sbjct: 1557 EKQRAL----QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1612
Query: 629 VGRNQLLEGKLQALQADYQALQQ-RESAIQGSLASLEAEQASIRHLGDQMEASLLAVR-K 686
+ LE ++LQ ++ A+ Q RE A + + EAE+A ++ E L + K
Sbjct: 1613 AEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQAEAERAR-----EEAERELERWQLK 1664
Query: 687 AKEAMKAQMAEKEAILQSK--EGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLI 744
A EA++ ++ +E Q + E ++ +EE E+ EAR R E Q +Q +L
Sbjct: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER-----EARRR--GKAEEQAVRQRELA 1717
Query: 745 EVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQR--LQAQVVDLQAKMRAA 802
E ++ Q G + LAA+ L + + E QGE QR L+ ++ LQ + AA
Sbjct: 1718 EQELEKQRQLAEG----TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1773
Query: 803 LDDQDKVQSQLSMAEAVL-----------REHKTLVQQLKEQNEALNRAHVQELLQCSER 851
+ +++++L+ A + E ++ ++ K++ EA +EL + + R
Sbjct: 1774 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-EAGRFRELAEEAAR 1832
Query: 852 EGALQEE--------RADEAQQREEELRALQEEL------SQAKCSSEEAQLEHAELQEQ 897
AL EE D A+QR E R L E+L ++ K +E A E E+
Sbjct: 1833 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1892
Query: 898 LHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREG----LERQ--- 950
L R D A ++ R+EE A Q D +E ++ R+ LERQ
Sbjct: 1893 LRRLAEDEA----------FQRRRLEEQ---AAQHKADIEERLAQLRKASDSELERQKGL 1939
Query: 951 VAGLQQEKESLQEKLKAAKA----AAGSLPGLQAQLAQAEQRAQ-SLQEAAHQELNTLK- 1004
V +++ ++E++ A KA AA L+ +L + A+ +L+ EL +
Sbjct: 1940 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1999
Query: 1005 FQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKA------TQADMGE 1058
QL+AE + R + A E + EE RQ +AA E VE+LKA + E
Sbjct: 2000 RQLAAE---EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2056
Query: 1059 KLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRER 1118
+ S LA+ +AA R E A +++ ++EL++ + Q ++L E R
Sbjct: 2057 QESARQLQLAQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2115
Score = 142 bits (357), Expect = 3e-33
Identities = 212/904 (23%), Positives = 386/904 (42%), Gaps = 127/904 (14%)
Query: 241 QLEVREKQLRERMQQL----DRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVA 296
+LE ++R M+ L R +E R+ + ++L+ E R R AE+ RL L
Sbjct: 1779 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1838
Query: 297 ELQKQWEVTQ---ATQNTVKELQTCLQGLELGAAEK-EEDYHTALRRLES---MLQPLAQ 349
E ++Q ++ + A Q E + +G A + + + AL+ E+ L+ LA+
Sbjct: 1839 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1898
Query: 350 ELEATRDSLDKKN-QHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQ 408
+ R L+++ QH A LA ++ +D+ + RQ+ + D ++ +++ E++
Sbjct: 1899 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE---RQKGLVEDTLRQRRQVEEEIL 1955
Query: 409 ALERERTKVEEVNRQQSAQLEQLVKELQ--LKEDARASLERLVKEMAPLQEELSGKGQEA 466
AL+ K + +L ++ + L+ +A LE + +EE + +EA
Sbjct: 1956 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREA 2013
Query: 467 DQLWRRLQELLAHTSSWEEE----LAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQL 522
++ R+Q+ LA + L E+ R K + +E + L E+ + RQLQ +
Sbjct: 2014 EE---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2070
Query: 523 -----AQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPV 577
A+ H +++++++L Q L Q+ +L++L G A E EA V
Sbjct: 2071 QKRLQAEEKAHAFAVQQKEQELQQT---LQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2127
Query: 578 NSSLQEAWGKPEEEQRGLQ----------EAQLDDTKVQEGSQEEELRQA---------- 617
++ + EE +R Q +AQ K+++ +++E R+A
Sbjct: 2128 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2187
Query: 618 ---NRELEKE---LQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIR 671
+ E+EK + + + +E +L L+ + +++ + L L+AE
Sbjct: 2188 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2247
Query: 672 HLGDQMEASLLAVRKAKEAMKAQMAEKEA-----ILQSKEGECQQLREEVEQCQQLAEAR 726
Q+E L +VR E + A EA IL+ K+ + L+EE E+ +Q+AE
Sbjct: 2248 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2307
Query: 727 HR---------ELRAL-ESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQA 776
R LR L E QQ L E + EK Q EA L A+ L Q
Sbjct: 2308 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ------AVQEATRLKAEAELLQQ 2361
Query: 777 QLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEA 836
Q E+ Q + +RLQ +DK Q +AE +TL + + Q E
Sbjct: 2362 QKELAQEQARRLQ----------------EDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2405
Query: 837 LNRAHVQELLQCSEREGALQEERADEAQQR-EEELRALQEELSQAKCSSEEAQLEHAELQ 895
A E L+ E + + RA+E QR ++ + E+L + + +++E L+
Sbjct: 2406 SAEA---ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2462
Query: 896 EQLHRANTDTAELGIQVCALTVEKERVEEALACA---------------VQELQDAKEAA 940
Q +++ D L + L EKE++++ +QE Q +++
Sbjct: 2463 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2522
Query: 941 SREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL-PGLQAQLAQAEQRAQ----SLQEA 995
E++ L ++ ++QEK L++ + A A L Q Q Q EQ Q S++EA
Sbjct: 2523 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2582
Query: 996 AHQ----ELNTLKFQLSAEIMDYQSRLKN--AGEECKSLRGQLEEQGRQLQAAEEAVEKL 1049
+ E + Q + ++ Q R + EE + LR QL+ Q +AA E++
Sbjct: 2583 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2642
Query: 1050 KATQ 1053
A+Q
Sbjct: 2643 TASQ 2646
Score = 129 bits (324), Expect = 2e-29
Identities = 207/880 (23%), Positives = 381/880 (43%), Gaps = 139/880 (15%)
Query: 385 TKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQ---LVKELQLKEDA 441
T G+ E + S +A +++L + + + R EEV R QL++ + L E
Sbjct: 1097 TLGKLEQVRSLSAIYLEKL-KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1155
Query: 442 RASLERLVKEMAP-------LQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREK 494
+ASL++L + L++EL G + ++L +R E W E +A+L
Sbjct: 1156 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1215
Query: 495 KQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQL----IQDKDHLSQQV 550
+ + ++ ++E+ L RQL++ + + D +++Q+ + D + +Q+
Sbjct: 1216 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1275
Query: 551 GMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDT------- 603
+ L E+ GEK E A K E Q +AQL+
Sbjct: 1276 RQEQALL----EEIERHGEKVEECQRFAKQYINAI-KDYELQLVTYKAQLEPVASPAKKP 1330
Query: 604 KVQEGSQE-----EELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQG 658
KVQ GS+ +LR EL + + + L+ ++ + + +Q+ + +
Sbjct: 1331 KVQSGSESVIQEYVDLRTHYSELTTLTSQYI---KFISETLRRMEEEERLAEQQRAEERE 1387
Query: 659 SLASLEAEQASIRHLGD-QMEASLLAVRKAKE---AMKAQMAEKEAILQSKEGECQQLRE 714
LA +EA R L + +A A R+AKE M+ ++ +E + + + ++E
Sbjct: 1388 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1447
Query: 715 EVEQCQQLAE----ARHRELRALES---QCQQQTQLIEV-LTAEKGQQGVGPPTDNEARE 766
E++Q +Q +E A+ R+ A E + +++ +++ + L A + Q+G + E +
Sbjct: 1448 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG---GAEGELQA 1504
Query: 767 LAAQLALSQAQLEVHQGEVQRLQAQVVD-LQAKMRAALDDQDKVQSQLSMAEAVLREHKT 825
L A+ ++AQ Q E +RL+ QV D Q K +A ++ +V+++ A RE +
Sbjct: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA----REKQR 1560
Query: 826 LVQQLKE-------------QNEALNRAHVQELLQCSER--EGALQEERADEAQQREEEL 870
+Q L+E Q E VQ L+ ++R E LQ +RA A++ +
Sbjct: 1561 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1620
Query: 871 RALQEE---LSQAKCSSEEAQLEHAELQEQLHRANTDTAELGI---QVCALTVEKERVEE 924
R+LQEE ++Q + +E + AE + A + + + L ++ E V +
Sbjct: 1621 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1680
Query: 925 ALACAVQELQDAKEAASRE--REGLERQVAGLQQE--KESLQEKLKAAK-------AAAG 973
+ A E + KE A RE R G + A Q+E ++ L+++ + A+ AA
Sbjct: 1681 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1740
Query: 974 SLPGLQAQLAQAEQRAQSLQE----------AAHQELNTLKFQLSAEIMDYQ-------- 1015
L L+A+ Q EQ+ Q L+E AA Q+ L+ +L+ + +
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1800
Query: 1016 --------------------SRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKA-TQA 1054
R + EE LR EE RQ Q AEE + +A +
Sbjct: 1801 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1860
Query: 1055 DMGEKLSC---TSNHLAECQAAMLRKDKEGAALR-----EDLERTQKELEKATTK--IQE 1104
+ EKL+ + E + A+ K+ E LR E +R + E + A K I+E
Sbjct: 1861 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1920
Query: 1105 YYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIEL 1144
+L ++ ++ E QK L ++D R ++ +EE ++ L
Sbjct: 1921 RLAQL-RKASDSELERQKGL--VEDTLRQRRQVEEEILAL 1957
Score = 113 bits (282), Expect = 2e-24
Identities = 182/798 (22%), Positives = 328/798 (41%), Gaps = 88/798 (11%)
Query: 229 LEGFDEMRLELDQLEVREKQLRERMQQ---LDRENQELRAAVSQQGEQLQTERERGRTAA 285
LE + +L ++ E R ++ ER+Q+ + E R A ++ E+L+ + E R
Sbjct: 1994 LEAARQRQLAAEE-ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2052
Query: 286 EDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQ 345
E AE + ++ A + K LQ + +KE++ L++ +S+L
Sbjct: 2053 ER--------AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2104
Query: 346 PLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGE 405
L E EA R + ++ + A ++++ + A K +A+E +
Sbjct: 2105 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK--------QSAEEQAQARA 2156
Query: 406 KLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQE 465
+ QA + K E + AQ EQ L+ K+ A A +E+ K + + QE
Sbjct: 2157 QAQAAAEKLRKEAEQEAARRAQAEQAA--LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2214
Query: 466 ADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQV 525
L +L+E + +EEL L+ E + ++ +E+E+ S+ Q++ L A++
Sbjct: 2215 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2274
Query: 526 SQHVSDLEEQKKQLIQDKDH----LSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSL 581
E + +++DKD+ L ++ ++++A L VA ++ + L
Sbjct: 2275 EA------ENRALILRDKDNTQRFLQEEAEKMKQVA-EEAARLSVAAQEA-------ARL 2320
Query: 582 QEAWGKPEEEQRGLQEAQLDDTK--VQEGSQ---EEELRQANRELEKELQNVVGRN---- 632
++ + +QR L E L + VQE ++ E EL Q +EL +E + +
Sbjct: 2321 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2380
Query: 633 -QLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAM 691
Q L + Q Q +A +QR+ + L+ A + + E RK E +
Sbjct: 2381 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2440
Query: 692 KAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ---CQQQTQLIEVLT 748
++ E Q K Q L + +Q AE + LE + QQ+ +L+++ +
Sbjct: 2441 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2500
Query: 749 AE----KGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALD 804
E + +Q + + L+ + +L Q + + Q E +L+ D AK + +
Sbjct: 2501 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ-EKAKLEQLFQDEVAKAQQLRE 2559
Query: 805 DQDKVQSQL---------SMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
+Q + Q Q+ SM EA R+H E E + R QE LQ E++
Sbjct: 2560 EQQRQQQQMEQERQRLVASMEEARRRQH--------EAEEGVRRK--QEELQQLEQQRRQ 2609
Query: 856 QEER-ADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHR--------ANTDTA 906
QEE A+E Q+ E+L+ L+E+ A SEE + L A
Sbjct: 2610 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2669
Query: 907 ELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQ-VAGLQQEKESLQE-K 964
E V +R++EA + +ELQ + + E R+ V Q + S+
Sbjct: 2670 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2729
Query: 965 LKAAKAAAGSLPGLQAQL 982
LKA LQ QL
Sbjct: 2730 LKATNEKLSVYAALQRQL 2747
Score = 104 bits (260), Expect = 6e-22
Identities = 248/1151 (21%), Positives = 429/1151 (37%), Gaps = 256/1151 (22%)
Query: 230 EGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNV 289
E + + EL+ E + K+L+ +L RE+ R V LQT+ +
Sbjct: 683 ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSW-------ML 735
Query: 290 RLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEE-DYHTALRRLESMLQPLA 348
+L C + K+ + V+E + LQ L+ K D + RLE +LQ
Sbjct: 736 QLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQ--- 792
Query: 349 QELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQ 408
D+ D+K Q L + G L+ ++A K P A M+ L
Sbjct: 793 -------DAQDEKEQ-LNEYKGHLSGLAKRAKAVVQLK------PRHPAHPMRGRLPLLA 838
Query: 409 ALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMA-----PLQE------ 457
+ ++ +V V++ QL + K + + E V + P QE
Sbjct: 839 VCDYKQVEV-TVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVT 897
Query: 458 ELSGKGQEADQLWRRLQELLAHTSSWEE-----------ELAELRREKKQQQ-------- 498
L + Q LW +L + +W+ LA R K ++Q
Sbjct: 898 RLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE 957
Query: 499 ------------------EEKELLEQEVRSLTRQLQFLETQLAQVSQH-------VSDLE 533
E++ + E+E S + Q L L Q +Q +S+L+
Sbjct: 958 LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 1017
Query: 534 EQKKQLIQDKDHLSQQVGM----------LERLAGPPGPELPVAG--------------- 568
+ + QL + ++ + +R+A + V G
Sbjct: 1018 DIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKV 1077
Query: 569 ----EKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTK----VQEGSQ-EEELRQANR 619
E + A + S L+ GK E+ R L L+ K V G+Q EE+ +A+
Sbjct: 1078 LALPEPSPAAPTLRSELELTLGK-LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE 1136
Query: 620 ELEKELQNVVGRNQLLE---GKLQALQADYQA---------------------LQQRE-- 653
E KE Q V LE L+ L+A +A LQQR
Sbjct: 1137 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1196
Query: 654 ----------------SAIQGSLASLEAEQASIRHLG----------DQMEASLLAVRKA 687
Q LA + Q + LG D + A L R+
Sbjct: 1197 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1256
Query: 688 KE-----------AMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ 736
+E A++ Q+ +++A+L+ E ++ E+VE+CQ+ A+ ++ E
Sbjct: 1257 QEQIQAMPLADSQAVREQLRQEQALLE----EIERHGEKVEECQRFAKQYINAIKDYE-- 1310
Query: 737 CQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQ-AQLEVHQGEVQRLQAQVVDL 795
++++T + + V P + ++ + + L H E+ L +Q +
Sbjct: 1311 -------LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1363
Query: 796 QAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
++ +++++++ Q E RE V+ E+ L AH Q Q L
Sbjct: 1364 ISETLRRMEEEERLAEQQRAEE---RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1420
Query: 856 QEERADEAQQREE-------ELRALQEELSQAKCSSE---EAQLEHAELQEQLH-RANTD 904
Q+ +E +REE + R++QEEL Q + SSE +A+ AE E+ R +
Sbjct: 1421 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1480
Query: 905 TAELGIQVCALTVEKERVE---EALACAVQELQDAKEAASREREGLERQVAGLQQEKESL 961
+ +Q+ A ++ E +AL +E + K A E E L RQV Q K
Sbjct: 1481 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1540
Query: 962 QEKL--------KAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKF-----QLS 1008
+ +L +AA+ +L L+ QAE+ + L++A + ++ Q S
Sbjct: 1541 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1600
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQLEE------------------QGRQLQAAEEAVEKLK 1050
AE + QS+ + E+ L L+E Q +A EEA +L+
Sbjct: 1601 AE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1659
Query: 1051 ATQADMGEKLS--------CTSNHLAECQAAMLRKDKEGAALR----EDLERTQKEL-EK 1097
Q E L LA+ +A +++ E A R E+ Q+EL E+
Sbjct: 1660 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1719
Query: 1098 ATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDA 1157
K ++ Q+ E+ ++ A+ + + ++ LEE L L R+ A QK
Sbjct: 1720 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1779
Query: 1158 LEFQ-QKLSAE 1167
LE + K+ AE
Sbjct: 1780 LEAELAKVRAE 1790
Score = 49.3 bits (116), Expect = 3e-05
Identities = 73/345 (21%), Positives = 147/345 (42%), Gaps = 24/345 (6%)
Query: 865 QREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRAN----TDTAELG---IQVCALTV 917
+RE++LR+ E L + + Q+E +EQL++A+ +D L + A V
Sbjct: 406 EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEV 465
Query: 918 EK--ERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL 975
E+ ++ + + ++Q K+ + E + R+V L + +++ + A +
Sbjct: 466 ERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAA 525
Query: 976 PGLQAQLAQAEQRAQSLQEAAHQELNTLKF--QLSAEIMDYQSRLKNA--GEECKSLRGQ 1031
P Q A+ QS+Q E +TL++ L A + + Q R+ A G + S+ Q
Sbjct: 526 PATQV----AQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ 581
Query: 1032 LEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERT 1091
L Q+ EE K++ ++D G+ T +C + R D + A L +
Sbjct: 582 LGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDC---LGRLDLQYAKLLNSSKAR 638
Query: 1092 QKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDAL 1151
+ LE + + +L + E+ ++++ D D N +E L+R+ +
Sbjct: 639 LRSLESLHSFVAAATKEL---MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 695
Query: 1152 WQKSDALE-FQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHC 1195
+K L+ +L E+ T + + ++SWM++ C
Sbjct: 696 EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCC 740
Score = 42.7 bits (99), Expect = 0.003
Identities = 56/242 (23%), Positives = 92/242 (38%), Gaps = 27/242 (11%)
Query: 197 RSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQL 256
+ + + L S +QT + L L D + +E + +L + Q
Sbjct: 2491 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2550
Query: 257 DRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQ 316
+ Q+LR +Q +Q++ ER+R LVA +++ + V+ Q
Sbjct: 2551 VAKAQQLREEQQRQQQQMEQERQR-------------LVASMEEARRRQHEAEEGVRRKQ 2597
Query: 317 TCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQ 376
LQ LE ++EE +RL LQ L E R +L + AS
Sbjct: 2598 EELQQLEQQRRQQEELLAEENQRLREQLQLLE---EQHRAALAHSEEVTASQVAATKTLP 2654
Query: 377 QKADTASDTKGRQEPIPS-------DAAQEMQELG----EKLQALERERTKVEEVNRQQS 425
D EP S +AQ +QE G E+LQ L + T V+E+ R++
Sbjct: 2655 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2714
Query: 426 AQ 427
+
Sbjct: 2715 VR 2716
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 161 bits (408), Expect = 4e-39
Identities = 240/1048 (22%), Positives = 453/1048 (43%), Gaps = 133/1048 (12%)
Query: 223 PLNNEALEGFDEMRLELDQLEVREKQL--RERMQQLDRENQELRAAVSQQGEQLQTERER 280
PL + + + M E + ++VREKQL R+ +++ +L A Q EQLQ E E
Sbjct: 836 PLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETEL 895
Query: 281 GRTAAEDNVRLTC-----------LVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEK 329
A E RLT L A ++++ E Q Q K++Q +Q LE E+
Sbjct: 896 CAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELE----EQ 951
Query: 330 EEDYHTALRRL-------ESMLQPLAQE---LEATRDSLDKKNQ----HLASFPGWLAMA 375
E+ +A ++L E+ L+ L +E LE L K+ + +A F L
Sbjct: 952 LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011
Query: 376 QQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQL---V 432
++K+ + + K + E + +D + ++ ++ Q LE+ R K+E + S Q+ +L +
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 433 KELQLK-----EDARASLERLVKEMAP-----------------LQEELSGKGQEADQLW 470
EL+++ E+ +A+L R+ +E A LQE+L + ++
Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAE 1131
Query: 471 RRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVS 530
++ ++L + + EL + QQE + EQEV L + L+ + H +
Sbjct: 1132 KQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLE------EEAKTHEA 1185
Query: 531 DLEEQKKQLIQDKDHLSQQVGMLERL-AGPPGPELPVAGEKNEALVPVNSSLQEAWGKPE 589
++E +++ Q + L++Q+ +R+ A + + E+ E V LQ GK +
Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQ---GKGD 1242
Query: 590 -EEQRGLQEAQLDDTKVQ--EGSQ-EEELRQANRELEKELQNVVGRNQLLEGKLQALQAD 645
E +R EAQL + +V+ EG + EL +L+ EL NV G + K L D
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD 1302
Query: 646 YQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVR---KAKEAMKAQMAEKEAIL 702
+ AL+ + Q L ++ S+ Q+E + R + +E K + ++ A L
Sbjct: 1303 FSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL 1362
Query: 703 QSKEGECQQLREEVEQCQQLAEARHREL-RALESQCQQQTQLIEVL-TAEKGQQGVGPPT 760
++ + ++ E+ C + AE R+L + LE Q+ + + EK + +
Sbjct: 1363 HAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQEL 1422
Query: 761 DNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKM-----RAALDDQDKVQSQLSM 815
D+ +L Q S LE Q + +L A+ + AK RA + ++K LS+
Sbjct: 1423 DDLLVDLDHQ-RQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSL 1481
Query: 816 AEAV--LREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRAL 873
A A+ E K +++L +Q R +++L+ + G + E+ RAL
Sbjct: 1482 ARALEEAMEQKAELERLNKQ----FRTEMEDLMSSKDDVG-------KSVHELEKSKRAL 1530
Query: 874 QEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQEL 933
++++ + K QLE EL+++L L + + A+ + ER +L
Sbjct: 1531 EQQVEEMK-----TQLE--ELEDELQATEDAKLRLEVNLQAMKAQFER----------DL 1573
Query: 934 QDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQ 993
Q E + +++ L RQV ++ E E +++ A AA L L A +
Sbjct: 1574 QGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNR 1633
Query: 994 EAAHQELNTLKFQLS----------AEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAE 1043
+ A ++L L+ Q+ A + ++ K ++ KS+ ++ + +L AAE
Sbjct: 1634 DEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAE 1693
Query: 1044 EAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQ-------KELE 1096
A + + + ++ ++++ +S A R + A L E+LE Q L+
Sbjct: 1694 RAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK 1753
Query: 1097 KATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSD 1156
KA +I + L E ++ ++N+ L R K L+ +L E+ + + K+
Sbjct: 1754 KANLQIDQINTDLNLERSHAQKNENAR----QQLERQNKELKVKLQEMEGTVKSKY-KAS 1808
Query: 1157 ALEFQQKLSAEERWLGDTEANHCLDCKR 1184
+ K++ E L + CK+
Sbjct: 1809 ITALEAKIAQLEEQLDNETKERQAACKQ 1836
Score = 147 bits (371), Expect = 7e-35
Identities = 198/936 (21%), Positives = 397/936 (42%), Gaps = 104/936 (11%)
Query: 234 EMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTC 293
E L + E + K L + + + +L + ++ +Q Q + R D+ L+
Sbjct: 1003 EFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSD 1062
Query: 294 LVAELQKQW-EVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELE 352
+AELQ Q E+ +ELQ L +E AA+K +R LES + L ++LE
Sbjct: 1063 QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKK-IRELESQISELQEDLE 1121
Query: 353 ATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQA-LE 411
+ R S +K + L + + + D+ Q+ + S QE+ L + L+ +
Sbjct: 1122 SERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAK 1181
Query: 412 RERTKVEEVNRQQSAQLEQLVKELQLKEDARASLER----LVKEMAPLQEE----LSGKG 463
+++E+ ++ S +E+L ++L+ + +A+LE+ L E L E L GKG
Sbjct: 1182 THEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKG 1241
Query: 464 Q---EADQLWRRLQELLAHTSSWEEELAELRRE--------------------------- 493
+ ++ +LQEL + E EL +
Sbjct: 1242 DSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTK 1301
Query: 494 -----KKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQ 548
+ Q Q+ +ELL++E RQ L T+L QV + EQ ++ + K +L +
Sbjct: 1302 DFSALESQLQDTQELLQEE----NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357
Query: 549 QVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQE--------------AWGKPEEEQRG 594
Q+ L ++ + E V LQ+ A+ K E+ +
Sbjct: 1358 QIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTR 1417
Query: 595 LQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKL--QALQADYQALQQR 652
LQ+ +LDD V Q + ++ +K+ ++ + + K + +A+ +A ++
Sbjct: 1418 LQQ-ELDDLLVDLDHQRQSACNLEKK-QKKFDQLLAEEKTISAKYAEERDRAEAEAREKE 1475
Query: 653 ESAIQGSLASLEA--EQASIRHLGDQMEASLLAVRKAKEAMKAQMAE----KEAILQSKE 706
A+ + A EA ++A + L Q + + +K+ + + E K A+ Q E
Sbjct: 1476 TKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVE 1535
Query: 707 GECQQLREEVEQCQQLAEARHR---ELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNE 763
QL E ++ Q +A+ R L+A+++Q ++ Q + + EK +Q V +
Sbjct: 1536 EMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLV-----RQ 1590
Query: 764 ARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREH 823
RE+ A+L + Q + ++L+ + DL+A + +A ++D+ QL +A +++
Sbjct: 1591 VREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD- 1649
Query: 824 KTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCS 883
+++L + RA +E+L A +E + + E E+ LQEEL+ A+ +
Sbjct: 1650 --CMRELDD-----TRASREEIL-------AQAKENEKKLKSMEAEMIQLQEELAAAERA 1695
Query: 884 SEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASRE 943
+AQ E EL +++ ++ A L ++ EK R+E +A +EL++ +
Sbjct: 1696 KRQAQQERDELADEIANSSGKGA-LALE------EKRRLEARIAQLEEELEEEQGNTELI 1748
Query: 944 REGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTL 1003
+ L++ + Q L + A+ + L+ Q + + + Q ++ +
Sbjct: 1749 NDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKAS 1808
Query: 1004 KFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCT 1063
L A+I + +L N +E ++ Q+ ++L+ V+ + ++
Sbjct: 1809 ITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKA 1868
Query: 1064 SNHLAECQAAMLRKDKEGAALREDLERTQKELEKAT 1099
S L + + + ++E + Q+ELE AT
Sbjct: 1869 STRLKQLKRQLEEAEEEAQRANASRRKLQRELEDAT 1904
Score = 121 bits (303), Expect = 6e-27
Identities = 190/846 (22%), Positives = 376/846 (44%), Gaps = 128/846 (15%)
Query: 219 DLNSPLNNEALEGFDEMRLELDQ-LEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTE 277
+L L++ A + E+R + +Q + + +K L E + + + QE+R SQ E+L +
Sbjct: 1147 ELEDTLDSTAAQ--QELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQ 1204
Query: 278 RERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTAL 337
E+ + A L+K Q +N EL ++ L G + E
Sbjct: 1205 LEQTKRVK----------ANLEK---AKQTLENERGELANEVKVLLQGKGDSEHKR---- 1247
Query: 338 RRLESMLQPLA---QELEATR----DSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQE 390
+++E+ LQ L E E R D + K L + G L+ + K+ + E
Sbjct: 1248 KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALE 1307
Query: 391 PIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDAR---ASLER 447
D + +QE + +L TK+++V ++++ EQL +E + K + A+L
Sbjct: 1308 SQLQDTQELLQEENRQKLSLS---TKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 448 LVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQE 507
V +M E+ G + A+++ R+LQ+ L S R E+K +K LE+
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQ--------RHEEKVAAYDK--LEKT 1414
Query: 508 VRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVA 567
L ++L L L Q +LE+++K+ Q L+++ + + A A
Sbjct: 1415 KTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQ---LLAEEKTISAKYAEERDRAEAEA 1471
Query: 568 GEKNEALVPVNSSLQEAWGKPEEEQRGLQE--AQLDD---TKVQEGSQEEELRQANRELE 622
EK + + +L+EA + E +R ++ +++D +K G EL ++ R LE
Sbjct: 1472 REKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531
Query: 623 KELQNVVGRNQLLEGKLQA-------LQADYQALQ-QRESAIQGSLASLEAEQASIRHLG 674
++++ + + + LE +LQA L+ + QA++ Q E +QG E ++ +
Sbjct: 1532 QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQV 1591
Query: 675 DQMEASLLAVRK-------AKEAMKAQMAEKEAILQS----KEGECQQLRE---EVEQCQ 720
+MEA L RK A++ ++ + + EA + S ++ +QLR+ +++ C
Sbjct: 1592 REMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCM 1651
Query: 721 Q------------LAEARHRE--LRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARE 766
+ LA+A+ E L+++E++ Q + E+ AE+ ++ E E
Sbjct: 1652 RELDDTRASREEILAQAKENEKKLKSMEAEMIQLQE--ELAAAERAKR----QAQQERDE 1705
Query: 767 LAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTL 826
LA ++A S + + E +RL+A++ L+ ++ + + + +L A + + T
Sbjct: 1706 LADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTD 1765
Query: 827 VQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEEL-----SQAK 881
+ L R+H Q+ E + +++ +EL+ +E+ S+ K
Sbjct: 1766 LN--------LERSHAQK-----------NENARQQLERQNKELKVKLQEMEGTVKSKYK 1806
Query: 882 CSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAAS 941
S + + A+L+EQL + QV R E+ L + ++ D + A
Sbjct: 1807 ASITALEAKIAQLEEQLDNETKERQAACKQV-------RRTEKKLKDVLLQVDDERRNAE 1859
Query: 942 REREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELN 1001
+ ++ ++ L+Q K L+E + A+ A S LQ +L A + A +A ++E++
Sbjct: 1860 QYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETA----DAMNREVS 1915
Query: 1002 TLKFQL 1007
+LK +L
Sbjct: 1916 SLKNKL 1921
Score = 108 bits (271), Expect = 3e-23
Identities = 157/744 (21%), Positives = 316/744 (42%), Gaps = 122/744 (16%)
Query: 210 QTQEMVSNFDLNSPLNNEALEGFDEMRLELDQL------------------EVREKQLRE 251
Q QE+ F+ + E + ++++ELD + E QL++
Sbjct: 1253 QLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQD 1312
Query: 252 RMQQLDRENQE-------LRAAVSQQG---EQLQTERERGRTAAEDNVRLTCLVAELQKQ 301
+ L EN++ L+ ++ EQL+ E E + L VA+++K+
Sbjct: 1313 TQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKK 1372
Query: 302 WEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKK 361
E + T +E++ LQ G +++ E+ A +LE L QEL+ LD +
Sbjct: 1373 MEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQ 1432
Query: 362 NQHLAS-------FPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERER 414
Q + F LA + + ++ + R E + + L L+ ++
Sbjct: 1433 RQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQK 1492
Query: 415 TKVEEVNRQQSAQLEQLV-------KELQLKEDARASLERLVKEMAPLQEELSGKGQEAD 467
++E +N+Q ++E L+ K + E ++ +LE+ V+EM EEL + Q +
Sbjct: 1493 AELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE 1552
Query: 468 QLWRRLQ-ELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVS 526
RL+ L A + +E +L + + +Q EEK+ + L RQ++ +E +L
Sbjct: 1553 DAKLRLEVNLQAMKAQFERDL----QGRDEQSEEKK------KQLVRQVREMEAELEDER 1602
Query: 527 QHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWG 586
+ S +K+L D L + + ++EA+ L++
Sbjct: 1603 KQRSMAVAARKKLEMDLKDLEAHIDSANK-------------NRDEAI----KQLRKLQA 1645
Query: 587 KPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADY 646
+ ++ R +LDDT+ S+EE L QA +E EK+L+++ L+ +L A +
Sbjct: 1646 QMKDCMR-----ELDDTR---ASREEILAQA-KENEKKLKSMEAEMIQLQEELAAAERAK 1696
Query: 647 QALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKE 706
+ QQ + +A+ + A LA+ + K ++A++A+ E L+ ++
Sbjct: 1697 RQAQQERDELADEIANSSGKGA-------------LALEE-KRRLEARIAQLEEELEEEQ 1742
Query: 707 GECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARE 766
G + + + +++ + + +L S Q+ +N ++
Sbjct: 1743 GNTELINDRLKKANLQIDQINTDLNLERSHAQK--------------------NENARQQ 1782
Query: 767 LAAQLALSQAQLEVHQGEVQ-RLQAQVVDLQAKMRAALDDQ--DKVQSQLSMAEAVLREH 823
L Q + +L+ +G V+ + +A + L+AK+ A L++Q ++ + + + + V R
Sbjct: 1783 LERQNKELKVKLQEMEGTVKSKYKASITALEAKI-AQLEEQLDNETKERQAACKQVRRTE 1841
Query: 824 KTLVQQLKEQNEALNRA--HVQELLQCSEREGALQ---EERADEAQQREEELRALQEELS 878
K L L + ++ A + + + S R L+ EE +EAQ+ R LQ EL
Sbjct: 1842 KKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELE 1901
Query: 879 QAKCSSEEAQLEHAELQEQLHRAN 902
A +++ E + L+ +L R +
Sbjct: 1902 DATETADAMNREVSSLKNKLRRGD 1925
Score = 100 bits (249), Expect = 1e-20
Identities = 138/657 (21%), Positives = 272/657 (41%), Gaps = 136/657 (20%)
Query: 228 ALEGFDEMRLELDQLEVREK-QLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAE 286
ALE + EL Q E R+K L +++Q++ E R EQL+ E E +
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFR-------EQLEEEEEAKHNLEK 1357
Query: 287 DNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQP 346
L VA+++K+ E + T +E++ LQ G +++ E+ A +LE
Sbjct: 1358 QIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTR 1417
Query: 347 LAQELEATRDSLDKKNQHLAS-------FPGWLAM------------------AQQKA-- 379
L QEL+ LD + Q + F LA A++K
Sbjct: 1418 LQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETK 1477
Query: 380 --------DTASDTKGRQEPIPSDAAQEMQEL-------GEKLQALERERTKVEEVNRQQ 424
+ A + K E + EM++L G+ + LE+ + +E+ +
Sbjct: 1478 ALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEM 1537
Query: 425 SAQLEQLVKELQLKEDARASLERLVKEM-APLQEELSGKGQEAD----QLWRRLQE---- 475
QLE+L ELQ EDA+ LE ++ M A + +L G+ ++++ QL R+++E
Sbjct: 1538 KTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAE 1597
Query: 476 ------------------------LLAHTSSW----EEELAELRREKKQQQE-------- 499
L AH S +E + +LR+ + Q ++
Sbjct: 1598 LEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDT 1657
Query: 500 --EKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLA 557
+E + + + ++L+ +E ++ Q+ + ++ E K+Q Q++D L+ ++ +
Sbjct: 1658 RASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIA---NSS 1714
Query: 558 GPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKV------------ 605
G L + + L+E G E L++A L ++
Sbjct: 1715 GKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQ 1774
Query: 606 QEGSQEEELRQANRELEKELQNVVGRNQ--------LLEGKLQAL-----------QADY 646
+ + ++L + N+EL+ +LQ + G + LE K+ L QA
Sbjct: 1775 KNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAAC 1834
Query: 647 QALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKE 706
+ +++ E ++ L ++ E+ + DQ + + +++ +K Q+ E E Q
Sbjct: 1835 KQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ----LKRQLEEAEEEAQRAN 1890
Query: 707 GECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNE 763
++L+ E+E + A+A +RE+ +L+++ ++ L V+ ++G G +D E
Sbjct: 1891 ASRRKLQRELEDATETADAMNREVSSLKNKL-RRGDLPFVVPRRMARKGAGDGSDEE 1946
Score = 74.7 bits (182), Expect = 6e-13
Identities = 81/354 (22%), Positives = 157/354 (44%), Gaps = 35/354 (9%)
Query: 842 VQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRA 901
V+ LLQ S +E + + + + RE++L A + L++ + + E +LQEQL
Sbjct: 834 VKPLLQVSRQEEEMMAKEEELVKVREKQL-AAENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 902 NTDTAELGIQVCALTVEKERVEEA---LACAVQELQDAKEAASREREGLERQVAGLQ--- 955
AE LT +K+ +EE L V+E ++ + E++ +++ + L+
Sbjct: 893 TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL 952
Query: 956 QEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQ 1015
+E+ES ++KL+ K +A+L + E+ Q + E + +L K L I ++
Sbjct: 953 EEEESARQKLQLEKVTT------EAKLKKLEEE-QIILEDQNCKLAKEKKLLEDRIAEFT 1005
Query: 1016 SRLKNAGEECKS--------------LRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLS 1061
+ L E+ KS L +L + +Q Q E+ KL+ D+ ++++
Sbjct: 1006 TNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIA 1065
Query: 1062 CTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKL--CQEVTNRER- 1118
+AE + + +K++E A +E + A KI+E +++ QE ER
Sbjct: 1066 ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERA 1125
Query: 1119 ---NDQKMLADL-DDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEE 1168
+K DL ++L K LE+ L ++ ++ + +K EE
Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE 1179
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 160 bits (405), Expect = 8e-39
Identities = 202/931 (21%), Positives = 407/931 (43%), Gaps = 178/931 (19%)
Query: 337 LRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDA 396
+RRL+ L + L + + L +AM QQ+ D + +Q P +
Sbjct: 216 MRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEP 275
Query: 397 AQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQ 456
+E++EL +K ++L + +L + +K+ Q + ++ ++R + +++
Sbjct: 276 -KELEELRDKNESL--------------TMRLHETLKQCQDLKTEKSQMDRKINQLSEEN 320
Query: 457 EELSGKGQEADQLWRRLQELLAH--------TSSWEEELAELRREKKQQQEEKELLEQEV 508
+LS K +E ++LQ+ L T W E+ A+L +E ++K+ LE+
Sbjct: 321 GDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEE-- 378
Query: 509 RSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAG 568
+ + L+ +L+Q+ +H+S L++ Q+K + V LE L
Sbjct: 379 -----KNEILQGKLSQLEEHLSQLQDNPP---QEKGEVLGDVLQLETL------------ 418
Query: 569 EKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNV 628
++ A + N++ +A + E +RG QEA+L + ++++L +L+ + N+
Sbjct: 419 KQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNL 478
Query: 629 VGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAK 688
+ LE QA Q + + +ASL +E ++ Q + L +++
Sbjct: 479 SQAKEELE----------QASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQA 528
Query: 689 EAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELR--ALESQCQQQTQLIEV 746
+ +AQ+A+ LQ +E Q LR +VEQ + + ++L+ A + + +Q ++
Sbjct: 529 KEKQAQLAQ---TLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQL 585
Query: 747 LTAEKGQQGVGPPTDNEAREL-------AAQLALSQAQLEV--------------HQGEV 785
TA + ++ D ++L AA+L + Q QL+V Q E
Sbjct: 586 ATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREK 645
Query: 786 QRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQEL 845
L +V +LQA + A +Q + Q+Q++ E LR + + +++ A + +QE
Sbjct: 646 AELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQ--KATEKERVAQEKDQLQEQ 703
Query: 846 LQCSER-----EGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQE---- 896
LQ + +G+L+EE+ A EE+ R + E ++ + E+ + E EL+E
Sbjct: 704 LQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAG 763
Query: 897 ------------QLHRANTDT-----AELGIQVCALTVEKERVEEALACAVQELQDAKEA 939
+ H+A T+ AE E E++ + +A + +D+++
Sbjct: 764 RKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQE 823
Query: 940 ASREREGLERQVAGLQQEKESLQEKLKAAKAAA---------------GSLPGLQAQLAQ 984
++ + Q+ L++E E +++L+ AK L L A LA+
Sbjct: 824 EAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLAR 883
Query: 985 AEQRAQSLQEAAHQ---ELNTLKFQLSA---EIMDYQSRLKNAGEECKSLRGQL------ 1032
A Q+ Q + A + +L+TL+ +++A E+ ++ ++ AGE+ ++ +L
Sbjct: 884 ALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPAR 943
Query: 1033 ----------EEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAML----RKD 1078
E+QGRQ + + A++ ++ MG +L L E Q +++
Sbjct: 944 AGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQE 1003
Query: 1079 KEGAALREDLERTQKE--LEKAT-----TKIQEYYNK-----------LCQEVTNRERND 1120
+E A L ++ R Q + LEKA ++Q N+ L +T +E D
Sbjct: 1004 REVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKD 1063
Query: 1121 QKM----------LADLDDLNRTKKYLEERL 1141
Q++ + +L++L +T K L+E+L
Sbjct: 1064 QELAKLRGLEAAQIKELEELRQTVKQLKEQL 1094
Score = 157 bits (397), Expect = 7e-38
Identities = 242/1077 (22%), Positives = 436/1077 (40%), Gaps = 168/1077 (15%)
Query: 239 LDQLEVREKQLRERMQQLDRENQELRAAV-SQQGEQLQTERERGRTAAEDNVRLTCLVAE 297
L QLE EK+ +++ L ++ Q A S Q Q +RE+ + + C+
Sbjct: 603 LKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETA 662
Query: 298 LQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDS 357
Q+Q E Q V EL+ L+ + A EKE +L+ LQ L + L+ T+ S
Sbjct: 663 RQEQHEA----QAQVAELELQLRSEQQKATEKERVAQEK-DQLQEQLQALKESLKVTKGS 717
Query: 358 LDKKNQHLASF--PGWLAMAQQKADTAS---DTKGRQEPIPSDAA------QEMQELGEK 406
L+++ + A +++ KA+T S K ++ + + A +Q+LGE
Sbjct: 718 LEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEA 777
Query: 407 LQA----LERERTKVEEVNRQQSAQLEQLVKELQL-KEDARASLERLVKEMAPLQEELSG 461
QA L RE + ++ EQLVKE+ +E S + + A QE+L
Sbjct: 778 HQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMT 837
Query: 462 KGQEADQLWRRLQE-------LLAHT----SSWEEELAELRREKKQQQEEKELLEQEVRS 510
+E ++ + LQE + +H+ S + ELAEL + ++ + E +
Sbjct: 838 LKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQK 897
Query: 511 LTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPEL------ 564
L L L+ ++A S+ V+ LE ++ + ++ S+++ AG PE
Sbjct: 898 LADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQG 957
Query: 565 --------------PVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQ 610
A + L + ++L E+ G+ +EE RG QE ++ + G
Sbjct: 958 RQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEE-RGQQEREVARLTQERGRA 1016
Query: 611 EEEL---RQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQ 667
+ +L + A ELE LQN + ++ LQ A AL ++E Q E
Sbjct: 1017 QADLALEKAARAELEMRLQNALNEQRVEFATLQEALA--HALTEKEGKDQ--------EL 1066
Query: 668 ASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARH 727
A +R L L +R+ + +K Q+A+KE S G + E EA
Sbjct: 1067 AKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALR 1126
Query: 728 RELRALESQCQQQTQLIEVLTAE-KGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQ 786
E+ LE QCQ+Q + + L + ++ D+ L QL +L Q +
Sbjct: 1127 AEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALA 1186
Query: 787 RLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNR------- 839
Q ++ + K++ +D+ ++Q++ +L+ L+E+ LNR
Sbjct: 1187 SAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEG 1246
Query: 840 ----------AHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQL 889
A ++ + ER LQ E A + + E AL+EE+ + +E+ ++
Sbjct: 1247 ESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRV 1306
Query: 890 EHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALA----------CAVQELQDAKE- 938
L+++L ELG ++ A + + E+AL+ V EL AK
Sbjct: 1307 ASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHL 1366
Query: 939 ----------AASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQR 988
A R RE LE+ +Q L+ +L A+ G L L+ ++A+ E+
Sbjct: 1367 CQQLQAEQAAAEKRHREELEQS----KQAAGGLRAELLRAQRELGELIPLRQKVAEQERT 1422
Query: 989 AQSL--QEAAHQE-LNTLKF------------------------------------QLSA 1009
AQ L ++A++ E L+ LK +L+A
Sbjct: 1423 AQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAA 1482
Query: 1010 EIMDYQSRLKNAGEECKSLRGQLE-----EQGRQLQAAEE-------------AVEKLKA 1051
D ++RL E +S +LE +G +++ EE VE+L+
Sbjct: 1483 VRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEV 1542
Query: 1052 TQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQ 1111
Q + +++ S LA+ A + ++ A++ +Q+E ++ ++ E +L Q
Sbjct: 1543 FQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQ 1602
Query: 1112 EVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEE 1168
+ E +M + KK + L E LR + L +++ L + + E
Sbjct: 1603 KEQAAEHYKLQMEKAKTHYD-AKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHE 1658
Score = 147 bits (371), Expect = 7e-35
Identities = 233/1020 (22%), Positives = 428/1020 (41%), Gaps = 143/1020 (14%)
Query: 238 ELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQL-QTERERG------RTAAEDNVR 290
EL++L + + L R+ + ++ Q+L+ SQ ++ Q E G R A +
Sbjct: 277 ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQ 336
Query: 291 LTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQE 350
L + EL + E ++ATQ + E Q L+ EL AA +++ L +LQ +
Sbjct: 337 LQDALNELTE--EHSKATQEWL-EKQAQLE-KELSAALQDK---KCLEEKNEILQGKLSQ 389
Query: 351 LEATRDSL-DKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQA 409
LE L D Q G + + A+ + + E G++
Sbjct: 390 LEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAK 449
Query: 410 LERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLE--------RLVKEMAPLQEELSG 461
L ER EE +Q S+ + L + A+ LE RL ++A L EL+
Sbjct: 450 LLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTT 509
Query: 462 KGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQ 521
Q + QEL +E+ A+L + +QQ++ + L +V L+ L+ E Q
Sbjct: 510 LNATIQQ---QDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQ 566
Query: 522 LAQV-----------SQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPP----GPELPV 566
L +V +Q ++ E+++ ++++D +Q+ LE+ +L V
Sbjct: 567 LKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQV 626
Query: 567 AGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQ--LDDTKVQEGSQEEELRQANRELEKE 624
A NEA +S+ +A + E R ++E Q ++ + ++ + ++ + +L E
Sbjct: 627 A---NEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSE 683
Query: 625 LQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLA--------SLEAEQ-------AS 669
Q + ++ + K Q LQ QAL++ +GSL +LE +Q A
Sbjct: 684 QQKATEKERVAQEKDQ-LQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAE 742
Query: 670 IRHLGDQ-----------------MEASLLAVRKAKEA----MKAQMAEKEAILQSKEGE 708
R L +Q +EA L + +A +A ++ ++AE A + E E
Sbjct: 743 TRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESE 802
Query: 709 CQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELA 768
C+QL +EV ++ E +E + Q+Q ++ EK +Q + EA+E
Sbjct: 803 CEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKE-ECEKARQEL-----QEAKEKV 856
Query: 769 AQL-ALSQAQLEVHQGEVQRLQA-------QVVDLQAKMRAALDDQDKVQSQLSMAEAVL 820
A + + S+ Q+ Q E+ L A QV + + + + DD +Q +++ +
Sbjct: 857 AGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEV 916
Query: 821 REHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERAD---------------EAQQ 865
+TLV++ EQ E +R V+E + +R+ EE+ EA+Q
Sbjct: 917 ARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQ 976
Query: 866 REEELRALQEEL--SQAKCSSEEAQLEH--AELQEQLHRANTDTAELGIQVCALTVEKER 921
EL L+ L SQ + E Q E A L ++ RA A+L ++ A + R
Sbjct: 977 MGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQ---ADLALEKAARAELEMR 1033
Query: 922 VEEAL---ACAVQELQDAKEAASREREGLERQVAGLQ-------QEKESLQEKLKAAKAA 971
++ AL LQ+A A E+EG ++++A L+ +E E L++ +K K
Sbjct: 1034 LQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQ 1093
Query: 972 AGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQ 1031
A + A+ A E +L L+ AE+ + + + E+ SL
Sbjct: 1094 LAKKEKEHASGSGAQSEAAGRTEPTGPKLEALR----AEVSKLEQQCQKQQEQADSLERS 1149
Query: 1032 LEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQ--AAMLRKDKEGAALRED-- 1087
LE + + A+E L+ + ++L + + LA Q A R + + ED
Sbjct: 1150 LEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEW 1209
Query: 1088 ---LERTQKELEKAT---TKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERL 1141
+ R ++E E+ + ++E + L ++V +E +++ + + + LEERL
Sbjct: 1210 KAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERL 1269
Score = 147 bits (371), Expect = 7e-35
Identities = 227/1022 (22%), Positives = 420/1022 (41%), Gaps = 141/1022 (13%)
Query: 219 DLNSPLNNEALEGFDEMRLELDQL-EVREKQLRERMQQLDRENQELRAAVSQQGEQLQTE 277
DL S ++N + + EL+Q + +L ++ L E L A + QQ ++L
Sbjct: 470 DLQSSISN-----LSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGL 524
Query: 278 RERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTAL 337
+++ + L LQ+Q + +Q ++ V++L + L+ E E E
Sbjct: 525 KQQAKEKQAQ------LAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR 578
Query: 338 RRLESMLQPLAQELEATRDSLDKKNQHLASFP----GWLAMAQQKADTASDTKGRQEPIP 393
+ L A+E EA+ D + L + L + QQ+ A++ + +
Sbjct: 579 QDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSV 638
Query: 394 SDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMA 453
+ A +E EL K++ L+ + + AQ+ +L +L+ ++ ER+ +E
Sbjct: 639 TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKD 698
Query: 454 PLQEELSG---------------KGQEADQL---WRRLQELLAHTSSWEEELAELRREKK 495
LQE+L K + AD L R + EL A T S E+ R+E +
Sbjct: 699 QLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELE 758
Query: 496 QQQEEKELLEQEVRSL----TRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVG 551
+++ ++ LE ++ L + + L +LA+ E + +QL++ +
Sbjct: 759 EERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVK------EVAA 812
Query: 552 MLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQE 611
ER E E L+ + ++A + +E + + + +++Q Q+
Sbjct: 813 WRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIE-SHSELQISRQQ 871
Query: 612 EELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIR 671
EL + + L + LQ V Q E + Q L D LQ++ +A +A LE +R
Sbjct: 872 NELAELHANLARALQQV----QEKEVRAQKLADDLSTLQEKMAATSKEVARLE---TLVR 924
Query: 672 HLGDQMEASLLAVRK------------AKEAMKAQMAEKEAILQSKEGECQQLREEVEQC 719
G+Q E + + K +E Q +A LQ+ E E +Q+ E+E+
Sbjct: 925 KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELER- 983
Query: 720 QQLAEARHRELRA--LESQCQQQTQLIEVLTAEKGQQ--GVGPPTDNEARELAAQLAL-- 773
LRA +ESQ QQQ E+GQQ V T R A LAL
Sbjct: 984 ----------LRAALMESQGQQQ--------EERGQQEREVARLTQERGR-AQADLALEK 1024
Query: 774 -SQAQLEVH-QGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAV-------LREHK 824
++A+LE+ Q + + + LQ + AL +++ +L+ + L E +
Sbjct: 1025 AARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELR 1084
Query: 825 TLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELS--QAKC 882
V+QLKEQ + H + GA Q E A + +L AL+ E+S + +C
Sbjct: 1085 QTVKQLKEQLAKKEKEH-------ASGSGA-QSEAAGRTEPTGPKLEALRAEVSKLEQQC 1136
Query: 883 SSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVE-----EALACAVQEL---Q 934
++ Q + E + RA+ + ++ +E++ E ALA A +EL +
Sbjct: 1137 QKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFR 1196
Query: 935 DAKEAASREREGLERQVAGLQQEKE-------SLQEKLKAAKAAAGSLPGLQAQLAQAEQ 987
+ S+ + + QVA +QE E SL+E++ G +L +
Sbjct: 1197 TKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVM 1256
Query: 988 RAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVE 1047
+ + L L+ + ++ R EE +SLR + E+Q + A E +
Sbjct: 1257 AESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQ----RVASENLR 1312
Query: 1048 KLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYN 1107
+ +QA+ E+L L Q +K++ + L+ + TQ + +
Sbjct: 1313 QELTSQAERAEEL---GQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPA-----K 1364
Query: 1108 KLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAE 1167
LCQ++ + +K ++L ++K+ ELLR + L + + +QK++ +
Sbjct: 1365 HLCQQLQAEQAAAEK--RHREELEQSKQAAGGLRAELLRAQREL---GELIPLRQKVAEQ 1419
Query: 1168 ER 1169
ER
Sbjct: 1420 ER 1421
Score = 139 bits (351), Expect = 2e-32
Identities = 212/900 (23%), Positives = 379/900 (42%), Gaps = 112/900 (12%)
Query: 227 EALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAE 286
EA+ E +QL RER + +E + A +Q L+ E E+ R +
Sbjct: 791 EAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQ 850
Query: 287 DNVRLTCLV---AELQ---KQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTA---- 336
+ + +ELQ +Q E+ + N + LQ +Q E+ A + +D T
Sbjct: 851 EAKEKVAGIESHSELQISRQQNELAELHANLARALQQ-VQEKEVRAQKLADDLSTLQEKM 909
Query: 337 ------LRRLESMLQPLAQELEATRDSLDKKNQHLASF-PGWLAMAQQKADTASDTKGRQ 389
+ RLE++++ ++ E L K+ P WL +Q+ T+
Sbjct: 910 AATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLE--EQQGRQFCSTQAAL 967
Query: 390 EPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKE-------LQLKEDAR 442
+ + +A Q EL AL + + +E QQ ++ +L +E L L++ AR
Sbjct: 968 QAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAAR 1027
Query: 443 ASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKE 502
A LE LQ L+ + E L L L ++ELA+LR + Q +E E
Sbjct: 1028 AELEMR------LQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELE 1081
Query: 503 LLEQEVRSLTRQLQFLETQLAQVSQHVSD-----------LEEQKKQLIQDKDHLSQQVG 551
L Q V+ L QL E + A S S+ LE + ++ + + +Q
Sbjct: 1082 ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQE 1141
Query: 552 MLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLD----DTKVQE 607
+ L E E++ AL + L+E + Q L AQ + TKVQ+
Sbjct: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQD 1201
Query: 608 GSQEEE---------LRQANRE------LEKELQNVVGRNQL-LEGKLQALQADYQALQQ 651
S+ E+ ++A R+ LE+E+ +++ R L EG+ + L+ A +
Sbjct: 1202 HSKAEDEWKAQVARGRQEAERKNSLISSLEEEV-SILNRQVLEKEGESKELKRLVMAESE 1260
Query: 652 RESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQ 711
+ ++ L L+AE AS + ++L R+ ++++ + AEK+ + +
Sbjct: 1261 KSQKLEERLRLLQAETASNSARAAERSSAL---REEVQSLREE-AEKQRVAS------EN 1310
Query: 712 LREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQL 771
LR+E+ + AE +EL+A + + Q+ Q + L E A+ L QL
Sbjct: 1311 LRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQL 1370
Query: 772 ALSQAQLEV-HQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQL 830
QA E H+ E+++ + L+A++ A Q ++ + + + V + +T QQL
Sbjct: 1371 QAEQAAAEKRHREELEQSKQAAGGLRAELLRA---QRELGELIPLRQKVAEQERT-AQQL 1426
Query: 831 KEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAK--------C 882
+ + + + ++L + G L EE ++ + L+ EL QA+
Sbjct: 1427 RAEKAS----YAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAA 1482
Query: 883 SSEEAQLEHAELQEQLHRANTD----TAELGIQVCALTVEKERVEEA---LACAVQELQD 935
+A+ AE+Q + + TA+ + E++R +E L V++L+
Sbjct: 1483 VRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEV 1542
Query: 936 AKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAG-----------SLPGLQAQLAQ 984
+ +++ E L +++A Q + Q+KLKA +A G L LQAQL+Q
Sbjct: 1543 FQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQ 1602
Query: 985 AEQRAQ--SLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAA 1042
EQ A+ LQ + K Q + E+ + L+ +E K LR + E G +LQ A
Sbjct: 1603 KEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQA 1662
Score = 138 bits (348), Expect = 3e-32
Identities = 178/765 (23%), Positives = 326/765 (42%), Gaps = 87/765 (11%)
Query: 427 QLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEE 486
Q+ +L K+L D R++ + L E+A ++ L+ K + + +R+ L
Sbjct: 215 QMRRLKKQLA---DERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLAL-------- 263
Query: 487 LAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHL 546
L E + + +E E L + SLT +L + + DL+ +K Q+ + + L
Sbjct: 264 LNEKQAASPLEPKELEELRDKNESLTMRLH-------ETLKQCQDLKTEKSQMDRKINQL 316
Query: 547 SQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQ 606
S++ G L L + L +S + W + + + A L D K
Sbjct: 317 SEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCL 376
Query: 607 EGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAE 666
E + E L+ +LE+ L + +G++ + L+Q + + + L+A
Sbjct: 377 E-EKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQAR 435
Query: 667 QASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEAR 726
+ Q EA LLA R E K Q++ LQS Q +EE+EQ Q AR
Sbjct: 436 VEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGAR 495
Query: 727 HRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALS-QAQLEVHQGEV 785
L A + + + ++ Q+ G +A+E AQLA + Q Q + QG
Sbjct: 496 ---LTAQVASLTSELTTLNATIQQQDQELAG--LKQQAKEKQAQLAQTLQQQEQASQG-- 548
Query: 786 QRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQEL 845
L+ QV L + ++ + +++ EA ++H + E+ EA R L
Sbjct: 549 --LRHQVEQLSSSLK---QKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAAL 603
Query: 846 LQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDT 905
Q AL++E+A + + +++L+ E A+ S +AQ E AEL ++
Sbjct: 604 KQLE----ALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEE----- 654
Query: 906 AELGIQVCALTVEKERVEEALACAVQELQ---DAKEAASREREGLERQVAGLQQEKESLQ 962
+Q C T +E+ E A ELQ + ++A +ER + QEK+ LQ
Sbjct: 655 ----LQACVETARQEQHEAQAQVAELELQLRSEQQKATEKER---------VAQEKDQLQ 701
Query: 963 EKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAG 1022
E+L+A K SL + L + ++RA E + ++ LK + + + ++ K
Sbjct: 702 EQLQALKE---SLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELE 758
Query: 1023 EECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKD---- 1078
EE +G LE + +QL A +A + + + ++ E ++ + H AE + L K+
Sbjct: 759 EERAGRKG-LEARLQQLGEAHQA--ETEVLRRELAEAMA--AQHTAESECEQLVKEVAAW 813
Query: 1079 ------------KEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLAD 1126
+ GA +E L ++E EKA ++QE K+ ++ E + +
Sbjct: 814 RERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNE 873
Query: 1127 LDDLNRTKKYLEERLIELLRDKDALWQK--SDALEFQQKLSAEER 1169
L +L+ R ++ +++K+ QK D Q+K++A +
Sbjct: 874 LAELHANL----ARALQQVQEKEVRAQKLADDLSTLQEKMAATSK 914
Score = 135 bits (341), Expect = 2e-31
Identities = 189/804 (23%), Positives = 340/804 (42%), Gaps = 136/804 (16%)
Query: 249 LRERMQQLDRENQELRAAV-----SQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWE 303
+ +Q+ E + LRAA+ QQ E+ Q ERE R E L E + E
Sbjct: 970 MEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAE 1029
Query: 304 VTQATQNTVKELQ----TCLQGLELGAAEKE-EDYHTA-LRRLESM----LQPLAQELEA 353
+ QN + E + T + L EKE +D A LR LE+ L+ L Q ++
Sbjct: 1030 LEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQ 1089
Query: 354 TRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERE 413
++ L KK + AS G S+ GR EP G KL+AL E
Sbjct: 1090 LKEQLAKKEKEHASGSG----------AQSEAAGRTEPT-----------GPKLEALRAE 1128
Query: 414 RTKVEEVNRQQSAQLEQLVKELQLKEDARAS-----------LERLVKEMAPLQEELSGK 462
+K+E+ ++Q Q + L + L+ + +RA LE +E+ Q L+
Sbjct: 1129 VSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASA 1188
Query: 463 GQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQL 522
+E ++Q+ W+ ++A R+E +++ LE+EV L RQ+ E +
Sbjct: 1189 QRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGES 1248
Query: 523 AQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQ 582
++ + V E +K Q ++++ L L A E++ AL
Sbjct: 1249 KELKRLVM-AESEKSQKLEER---------LRLLQAETASNSARAAERSSAL-------- 1290
Query: 583 EAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQAL 642
EE + L+E + E+ R A+ L +EL + R + L +L+A
Sbjct: 1291 ------REEVQSLRE------------EAEKQRVASENLRQELTSQAERAEELGQELKAW 1332
Query: 643 QADYQALQQRESAIQ---GSLASLEAEQASIRHLGDQMEASLLAVRK-----AKEAMKAQ 694
Q + +Q S +Q S +L +E +HL Q++A A K +++ +A
Sbjct: 1333 QEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAA 1392
Query: 695 MAEKEAILQSKE--GECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEV---LTA 749
+ +L+++ GE LR++V + ++ A+ +LRA ++ +Q +++ L A
Sbjct: 1393 GGLRAELLRAQRELGELIPLRQKVAEQERTAQ----QLRAEKASYAEQLSMLKKAHGLLA 1448
Query: 750 EK----------GQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQR--------LQAQ 791
E+ G+Q + D + +LA +A E EVQR L+
Sbjct: 1449 EENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVM 1508
Query: 792 VVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNR--AHVQELLQCS 849
+ L+++ + Q + A + + + ++ +Q E L++ A + +
Sbjct: 1509 TAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQ 1568
Query: 850 EREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELG 909
+++ + + E+QQ + L+A EL QA+ S +E EH +LQ + + + D
Sbjct: 1569 QQKLKAVQAQGGESQQEAQRLQAQLNEL-QAQLSQKEQAAEHYKLQMEKAKTHYD----- 1622
Query: 910 IQVCALTVEKERVEEALACAVQELQDAKE-AASREREGLERQVAGLQQEKESLQEKLKAA 968
A + + ++E L Q ++ KE A ER G E Q AGL+ +E +
Sbjct: 1623 ----AKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLK-----TKEAEQTC 1673
Query: 969 KAAAGSLPGLQAQLAQAEQRAQSL 992
+ + L+AQ+A A+Q+ + L
Sbjct: 1674 RHLTAQVRSLEAQVAHADQQLRDL 1697
Score = 77.8 bits (190), Expect = 7e-14
Identities = 152/703 (21%), Positives = 270/703 (38%), Gaps = 83/703 (11%)
Query: 179 ARRTLTTGSSAYLWKPP--SRSSSMSSLVSSYLQTQEMVSNF----DLNSPLNNEALEGF 232
A R G W+ + ++S+L + TQ +VS L L E
Sbjct: 1319 AERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE 1378
Query: 233 DEMRLELDQ---------LEVREKQ--------LRERMQQLDRENQELRAAVSQQGEQLQ 275
R EL+Q E+ Q LR+++ + +R Q+LRA + EQL
Sbjct: 1379 KRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLS 1438
Query: 276 TERERGRTAAEDNVRLTCLVAELQKQW---EVTQATQNTVKELQTCLQGLELGAAEKEED 332
++ AE+N L A L +Q+ E+ QA + V+EL E AE + +
Sbjct: 1439 MLKKAHGLLAEENRGLGER-ANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQRE 1497
Query: 333 YHTALRRLESML---QPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQ 389
+ R LE M + ++ R ++ Q L + L + Q++ T + +
Sbjct: 1498 AQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE-QTKQVEELSK 1556
Query: 390 EPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLV 449
+ SD A ++Q+ +KL+A++ + + ++ ++ AQL +L +L KE A + +
Sbjct: 1557 KLADSDQASKVQQ--QKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQM 1614
Query: 450 KEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVR 509
++ + + QE + R L++L E L E +Q + + EQ R
Sbjct: 1615 EKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCR 1674
Query: 510 SLTRQLQFLETQLAQVSQHVSDL-------EEQKKQLIQDKDHLSQQVGMLE-------- 554
LT Q++ LE Q+A Q + DL + K + Q K L + L+
Sbjct: 1675 HLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTP 1734
Query: 555 -------RLAGPPGPELP--VAGEKNEALVPVNSSLQEAWGKP-EEEQRGLQEAQLDDTK 604
P G +P A ++ L P SL+ + P + E+ LD
Sbjct: 1735 LSITSKLPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLG 1794
Query: 605 VQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLE 664
+ R A R + + + + +E A + Y + A Q SL +
Sbjct: 1795 DVFLDSGRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYST--RSAPASQASLRATS 1852
Query: 665 AEQASIRHLG--DQMEASLLAVRKAKEAMKAQMAEKEAILQSKE---------GECQQLR 713
+ Q S+ LG D ++LL++ + ++ +A + S G CQ
Sbjct: 1853 STQ-SLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEP 1911
Query: 714 EEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLAL 773
E+++ ++AE + R C + L + + +G TD E + Q L
Sbjct: 1912 EQLDDWNRIAELQQR-----NRVCPPHLKTCYPLES-RPSLSLGTITDEEMKTGDPQETL 1965
Query: 774 SQAQLEVHQ-----GEVQRLQAQVVDLQAKMRAALDDQDKVQS 811
+A ++ Q G R Q + V L+ + K S
Sbjct: 1966 RRASMQPIQIAEGTGITTRQQRKRVSLEPHQGPGTPESKKATS 2008
Score = 60.1 bits (144), Expect = 2e-08
Identities = 104/492 (21%), Positives = 199/492 (40%), Gaps = 66/492 (13%)
Query: 213 EMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGE 272
E SN + ++ E +R E ++ V + LR+ + +EL G+
Sbjct: 1275 ETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEEL-------GQ 1327
Query: 273 QLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEED 332
+L+ +E+ + ++ LQ + TQA + + + Q L+ A E+
Sbjct: 1328 ELKAWQEKFFQKEQ-------ALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKR 1380
Query: 333 YHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPI 392
+ L + + L EL + L G L +QK QE
Sbjct: 1381 HREELEQSKQAAGGLRAELLRAQREL-----------GELIPLRQKV-------AEQERT 1422
Query: 393 PSDAAQEMQELGEKLQALERERTKVEEVNR--QQSAQLEQLVKELQLKEDARASLERLVK 450
E E+L L++ + E NR + A L + E++L + ++ L
Sbjct: 1423 AQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAA 1482
Query: 451 EMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRS 510
A + L+ +EA R L+ + T+ +E ++ E+++ QEE++ L +V
Sbjct: 1483 VRADAETRLAEVQREAQSTARELEVM---TAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
Query: 511 L-------TRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPE 563
L T+Q++ L +LA S S +++QK + +Q + SQQ +RL
Sbjct: 1540 LEVFQREQTKQVEELSKKLAD-SDQASKVQQQKLKAVQAQGGESQQEA--QRL------- 1589
Query: 564 LPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLD-DTKVQEGSQEEELRQANRELE 622
+ NE ++ Q A E + +++A+ D K Q+ + +E ++ +L+
Sbjct: 1590 ---QAQLNELQAQLSQKEQAA----EHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQ 1642
Query: 623 KELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLL 682
KE + + + L +LQ + +Q + + SLEA+ A DQ L
Sbjct: 1643 KENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAH----ADQQLRDLG 1698
Query: 683 AVRKAKEAMKAQ 694
+ A +A+K++
Sbjct: 1699 KFQVATDALKSR 1710
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 156 bits (395), Expect = 1e-37
Identities = 257/998 (25%), Positives = 436/998 (43%), Gaps = 137/998 (13%)
Query: 238 ELDQLEVREK-QLRERMQQLDRENQELRAAVSQQGEQLQTERE--------RGRTAAEDN 288
EL Q RE +L+ R+ QL+ E L EQL+ E E RGR AA
Sbjct: 891 ELQQQSAREVGELQGRVAQLEEERARL-------AEQLRAEAELCAEAEETRGRLAARKQ 943
Query: 289 VRLTCLVAELQ----KQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALR----RL 340
L +V+EL+ ++ E ++ Q K LQ +Q LE E EE L+
Sbjct: 944 -ELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE-AHLEAEEGARQKLQLEKVTT 1001
Query: 341 ESMLQPLAQELEATRDSLDKKNQ-------HLASFPGWLAMAQQKADTASDTKGRQEPIP 393
E+ ++ ++L D K ++ LA F A ++K + + + + E
Sbjct: 1002 EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATI 1061
Query: 394 SDAAQEMQELGEKLQALERERTKVEEVNRQ---QSAQL-EQLVKELQLKEDARASLERLV 449
+D + ++L+ E+ R ++E++ R+ +S++L EQ+V++ Q E+ RA L R
Sbjct: 1062 AD-------MEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKE 1114
Query: 450 KEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVR 509
+E+ +G QL + L+E A + +E+L R + + ++++ L +E+
Sbjct: 1115 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELE 1174
Query: 510 SLTRQLQ-FLETQLAQV---SQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELP 565
+L +L+ L++ AQ S+ ++ E KK L ++ V L + G
Sbjct: 1175 ALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG------Q 1228
Query: 566 VAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQE---EELRQANRELE 622
GE E L + AW E+ R EA++ + + + S + +E Q R LE
Sbjct: 1229 ALGELAEQLEQARRG-KGAW----EKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE 1283
Query: 623 KELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASL-EAEQASIRHLGDQMEASL 681
+LQ V GR +G+ +A + LQ+ ++ ++ +L EAE +IR L ++ ++
Sbjct: 1284 LQLQEVQGRAG--DGERARAEA-AEKLQRAQAELENVSGALNEAESKTIR-LSKELSSTE 1339
Query: 682 LAVRKAKEAMKAQMAEKEAI---LQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQ 738
+ A+E ++ + K A+ +++ E E LRE++E+ E REL+ ++Q
Sbjct: 1340 AQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLS 1399
Query: 739 QQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGE-VQRLQAQVVDLQA 797
+ + E E G G EAR AA+ A + Q + E V RL+ LQ
Sbjct: 1400 EWRRRQE---EEAGALEAG----EEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQ 1452
Query: 798 KMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQE 857
++ A D ++ Q + + ++ + Q L E+ A+ R A++E
Sbjct: 1453 ELDDATMD---LEQQRQLVSTLEKKQRKFDQLLAEEKAAVLR--------------AVEE 1495
Query: 858 ERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTV 917
EA+ RE E RAL S A E E +E+L R N L ++ AL
Sbjct: 1496 RERAEAEGREREARAL---------SLTRALEEEQEAREELERQN---RALRAELEALLS 1543
Query: 918 EKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLP- 976
K+ V + +V EL+ A A + L QV L+++L AA+ A L
Sbjct: 1544 SKDDVGK----SVHELERACRVAEQAANDLRAQVT-------ELEDELTAAEDAKLRLEV 1592
Query: 977 GLQAQLAQAEQRAQSLQEAAHQELNTLKFQL-SAEIMDYQSRLKN--AGEECKSLRGQLE 1033
+QA Q E+ Q EA + L QL AE+ + R + A K L G+LE
Sbjct: 1593 TVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELE 1652
Query: 1034 EQGRQL----QAAEEAVEKLKATQADMGE---KLSCTSNHLAECQAAMLRKDKEGAALRE 1086
E Q+ Q EEAV++L+ QA M E ++ T E + +K L
Sbjct: 1653 ELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEA 1712
Query: 1087 DLERTQKEL---EKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIE 1143
++ R Q+EL ++A + Q+ +++ EV N + +L + L LEE L E
Sbjct: 1713 EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEE 1772
Query: 1144 LLRDKDALWQKSDALEFQ-----QKLSAEERWLGDTEA 1176
+ + L + L Q +LSAE + E+
Sbjct: 1773 EQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAES 1810
Score = 133 bits (334), Expect = 1e-30
Identities = 219/985 (22%), Positives = 402/985 (40%), Gaps = 153/985 (15%)
Query: 212 QEMVSNFDLNSPLNNEALEGFDEMRLELD----QLEVREKQLRERMQQLDRENQELRAAV 267
++ ++ F + E ++ +++RL+ + +E R ++ + Q+L++ + L
Sbjct: 1030 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1089
Query: 268 SQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAA 327
S+ EQ+ +++R A E +L ELQ + +L L+ + A
Sbjct: 1090 SELQEQMVEQQQR---AEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALA 1146
Query: 328 EKEEDYHT---ALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASD 384
E +ED + A + E + L +ELEA R L+ DT
Sbjct: 1147 EAQEDLESERVARTKAEKQRRDLGEELEALRGELE--------------------DTLDS 1186
Query: 385 TKGRQEPIPSDAAQEMQELGEKLQALER-ERTKVEEVNRQQSAQLEQLVKELQLK----- 438
T +QE + S QE+ EL + L+ R V+E+ ++ L +L ++L+
Sbjct: 1187 TNAQQE-LRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKG 1245
Query: 439 --EDARASLERLVKEMAPLQEELSGKGQEADQLWRRL----QELLAHTSSWEEELAELRR 492
E R +LE V E+ L QE +Q RRL QE+ E AE
Sbjct: 1246 AWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAE 1305
Query: 493 EKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGM 552
+ ++ Q E E + + + L +L+ + D +E ++ + K L +V
Sbjct: 1306 KLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRA 1365
Query: 553 LERLAGPPGPELPVAGEKNEA----LVPVNSSLQEAWGKPEEEQRGLQEA---------- 598
+E A +L E L + L E W + +EE+ G EA
Sbjct: 1366 MEAEAAGLREQLEEEAAARERAGRELQTAQAQLSE-WRRRQEEEAGALEAGEEARRRAAR 1424
Query: 599 ---QLDDTKVQEGSQEEELRQANRELEKELQNV---VGRNQLLEGKLQALQADY-QALQQ 651
L ++ + L + R L++EL + + + + L L+ Q + Q L +
Sbjct: 1425 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1484
Query: 652 RESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAM-----------KAQMAEKEA 700
++A+ ++ E +A G + EA L++ +A E +A AE EA
Sbjct: 1485 EKAAVLRAVEERERAEAE----GREREARALSLTRALEEEQEAREELERQNRALRAELEA 1540
Query: 701 ILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTA----------- 749
+L SK+ + + E +E+ ++AE +LRA Q T+L + LTA
Sbjct: 1541 LLSSKDDVGKSVHE-LERACRVAEQAANDLRA------QVTELEDELTAAEDAKLRLEVT 1593
Query: 750 --------EKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQR---------LQAQV 792
E+ QG + R+LA QL A++E + QR L+ ++
Sbjct: 1594 VQALKTQHERDLQGRDEAGEERRRQLAKQLR--DAEVERDEERKQRTLAVAARKKLEGEL 1651
Query: 793 VDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEAL---NRAHVQELLQCS 849
+L+A+M +A +++ QL +A ++E V++ + E + NR + L
Sbjct: 1652 EELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLE 1711
Query: 850 EREGALQEERAD------EAQQREEEL--RALQEELSQAKCSSEEAQLEH--AELQEQLH 899
LQEE A +AQQ +E+ LS+A E+ QLE +L+E+L
Sbjct: 1712 AEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELE 1771
Query: 900 RANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKE 959
+++ L + L ++ E + L+ + A R+ LERQ+ Q+ +
Sbjct: 1772 EEQSNSELLNDRYRKLLLQVESLTTELSAE----RSFSAKAESGRQQLERQI---QELRG 1824
Query: 960 SLQEKLKAAKAAAG-SLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRL 1018
L E+ A+A ++ L+++LAQAE++ E T + LS +++
Sbjct: 1825 RLGEEDAGARARHKMTIAALESKLAQAEEQL---------EQETRERILSGKLV------ 1869
Query: 1019 KNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKD 1078
+ A + K + Q+EE+ R + +EK + +L + QA R
Sbjct: 1870 RRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQ 1929
Query: 1079 KEGAALREDLERTQKELEKATTKIQ 1103
+E + E E +E+ +++
Sbjct: 1930 RELEDVTESAESMNREVTTLRNRLR 1954
Score = 130 bits (326), Expect = 1e-29
Identities = 232/965 (24%), Positives = 407/965 (42%), Gaps = 133/965 (13%)
Query: 219 DLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTER 278
D+ L E +G E+ +L+ +L+E+M + + +ELRA + ++ E+LQ
Sbjct: 1063 DMEDRLRKEE-KGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAAL 1121
Query: 279 ERGRTAAEDNVRLT-------CLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKE- 330
R +L +AE Q+ E ++ T E Q G EL A E
Sbjct: 1122 ARAEDEGGARAQLLKSLREAQAALAEAQEDLE-SERVARTKAEKQRRDLGEELEALRGEL 1180
Query: 331 EDYHTALRRLESMLQPLAQELEATRDSLDKKN-------QHLASFPGW-LAMAQQKADTA 382
ED + + + QE+ + +L+++ Q L G L ++ + A
Sbjct: 1181 EDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQA 1240
Query: 383 SDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDAR 442
KG E E+ EL +L +L+ R + E+ R+ QL+++ E AR
Sbjct: 1241 RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERAR 1300
Query: 443 A-SLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQ--- 498
A + E+L + A L E +SG EA+ RL + L+ T + + EL +E+ + +
Sbjct: 1301 AEAAEKLQRAQAEL-ENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL 1359
Query: 499 -EEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLA 557
+E E L Q LE + A + +L+ + QL + + ++ G LE A
Sbjct: 1360 GSRVRAMEAEAAGLREQ---LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE--A 1414
Query: 558 GPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQA 617
G A + EAL + E + E +R LQ+ +LDD + E+ RQ
Sbjct: 1415 GEEARRR--AAREAEALTQRLAEKTETVDRLERGRRRLQQ-ELDDATM----DLEQQRQL 1467
Query: 618 NRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASI-RHLGDQ 676
LEK+ + +QLL + A+ +A+++RE A + EA S+ R L ++
Sbjct: 1468 VSTLEKKQRKF---DQLLAEEKAAV---LRAVEERERA-EAEGREREARALSLTRALEEE 1520
Query: 677 MEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ 736
EA + + +A AE EA+L SK+ + + E+E+ ++AE +LRA
Sbjct: 1521 QEAR----EELERQNRALRAELEALLSSKDDVGKSV-HELERACRVAEQAANDLRA---- 1571
Query: 737 CQQQTQLIEVLTA-------------------EKGQQGVGPPTDNEARELAAQLALSQAQ 777
Q T+L + LTA E+ QG + R+LA Q L A+
Sbjct: 1572 --QVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQ--LRDAE 1627
Query: 778 LEVHQGEVQR---------LQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQ 828
+E + QR L+ ++ +L+A+M +A +++ QL +A ++E V+
Sbjct: 1628 VERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVE 1687
Query: 829 QLKEQNEAL---NRAHVQELLQCSEREGALQEERA------DEAQQREEEL--RALQEEL 877
+ + E + NR + L LQEE A +AQQ +E+ L
Sbjct: 1688 ETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNL 1747
Query: 878 SQAKCSSEEAQLEH--AELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQD 935
S+A E+ QLE +L+E+L +++ L + L ++ E + L+ +
Sbjct: 1748 SKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAE----RS 1803
Query: 936 AKEAASREREGLERQVAGLQQEKESLQEKLKAAKAA-AGSLPGLQAQLAQAEQRAQ---- 990
A R+ LERQ+ Q+ + L E+ A+A ++ L+++LAQAE++ +
Sbjct: 1804 FSAKAESGRQQLERQI---QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETR 1860
Query: 991 ------SLQEAAHQELNTLKFQLSAE--IMD-YQSRLKNAGEECKSLRGQLEEQGRQLQA 1041
L A + L + Q+ E + D + +L+ K L+ QLEE +
Sbjct: 1861 ERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASR 1920
Query: 1042 AEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLR--------------KDKEGAALRED 1087
A+ +L+ D+ E + + + + R + +EG A E+
Sbjct: 1921 AQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEE 1980
Query: 1088 LERTQ 1092
E Q
Sbjct: 1981 AEEAQ 1985
Score = 118 bits (295), Expect = 5e-26
Identities = 190/781 (24%), Positives = 324/781 (41%), Gaps = 92/781 (11%)
Query: 396 AAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPL 455
A Q+ Q+ L+ ++R ++ Q +L VK L L+ +E+ +
Sbjct: 830 AFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQELQKV 889
Query: 456 QEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQL 515
QE +E +L R+ +L EEE A L + + + E E+ L +
Sbjct: 890 QELQQQSAREVGELQGRVAQL-------EEERARLAEQLRAEAELCAEAEETRGRLAARK 942
Query: 516 QFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLE-RLAGPPGPELPVAGEK--NE 572
Q LE ++++ V + EE +Q+ +K L Q + LE L G + EK E
Sbjct: 943 QELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTE 1002
Query: 573 ALV---PVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQAN----------- 618
A + + L E ++R L E +L + Q +EE+++ N
Sbjct: 1003 AKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIA 1062
Query: 619 ------RELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAE-QASIR 671
R+ EK Q + + L+G+ LQ QQR ++ L E E QA++
Sbjct: 1063 DMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALA 1122
Query: 672 HLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVE-QCQQLAEARHREL 730
D+ A ++ +EA +A +AE + L+S+ + R + E Q + L E EL
Sbjct: 1123 RAEDEGGARAQLLKSLREA-QAALAEAQEDLESE----RVARTKAEKQRRDLGE----EL 1173
Query: 731 RALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQ- 789
AL +L + L + QQ + + E EL L + + +H+ VQ L+
Sbjct: 1174 EALRG------ELEDTLDSTNAQQELRSKREQEVTELKKTL---EEETRIHEAAVQELRQ 1224
Query: 790 ------AQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQ 843
++ + + R +K + L + LR + +Q +++ E R
Sbjct: 1225 RHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLEL 1284
Query: 844 ELLQCSEREGALQEERADEA---QQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHR 900
+L + R G + RA+ A Q+ + EL + L++A+ + E + + QLH
Sbjct: 1285 QLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHD 1344
Query: 901 ANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQ----- 955
A E AL + R EA A ++E Q +EAA+RER G E Q A Q
Sbjct: 1345 AQELLQEETRAKLALG-SRVRAMEAEAAGLRE-QLEEEAAARERAGRELQTAQAQLSEWR 1402
Query: 956 --QEKE--SLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEA---AHQELNTLKFQLS 1008
QE+E +L+ +A + AA L +LA+ + L+ QEL+ L
Sbjct: 1403 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL- 1461
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQL--EEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNH 1066
+ Q +L + E+ + QL EE+ L+A EE E+ +A + + +
Sbjct: 1462 ----EQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER-ERAEAEGREREARALSLTRA 1516
Query: 1067 LAECQAAMLRKDKEGAALREDLE----------RTQKELEKATTKIQEYYNKLCQEVTNR 1116
L E Q A +++ ALR +LE ++ ELE+A ++ N L +VT
Sbjct: 1517 LEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTEL 1576
Query: 1117 E 1117
E
Sbjct: 1577 E 1577
Score = 111 bits (278), Expect = 5e-24
Identities = 168/722 (23%), Positives = 299/722 (41%), Gaps = 80/722 (11%)
Query: 209 LQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVS 268
LQ QE+ EA E + EL+ + + + +L +E A +
Sbjct: 1284 LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH 1343
Query: 269 QQGEQLQTERERGRTAAEDNVR-LTCLVAELQKQWEVTQATQNTV-KELQTCLQGL---- 322
E LQ E R + A VR + A L++Q E A + +ELQT L
Sbjct: 1344 DAQELLQ-EETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWR 1402
Query: 323 -----ELGAAEK-EEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQ 376
E GA E EE A R E++ Q LA++ E T D L++ + L Q
Sbjct: 1403 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTE-TVDRLERGRRRL----------Q 1451
Query: 377 QKADTASDTKGRQEPIPSDAAQEM----QELGEKLQALER---ERTKVEEVNRQQSAQLE 429
Q+ D A+ +Q + S ++ Q L E+ A+ R ER + E R++ A+
Sbjct: 1452 QELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1511
Query: 430 QLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAE 489
L + L+ +++AR LER + L+ EL D + + + EL E+ +
Sbjct: 1512 SLTRALEEEQEAREELER---QNRALRAELEALLSSKDDVGKSVHELERACRVAEQAAND 1568
Query: 490 LRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQ 549
LR + + ++E E L +Q L+T QH DL+ + + + + L++Q
Sbjct: 1569 LRAQVTELEDELTAAEDAKLRLEVTVQALKT------QHERDLQGRDEAGEERRRQLAKQ 1622
Query: 550 V--GMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQE 607
+ +ER L VA K + L+E + +G +EA K+Q
Sbjct: 1623 LRDAEVERDEERKQRTLAVAARKK-----LEGELEELKAQMASAGQGKEEAVKQLRKMQ- 1676
Query: 608 GSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQ 667
+Q +EL + E + + +N+ E +L+ L+A+ LQ+ +A + + ++
Sbjct: 1677 -AQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDR 1735
Query: 668 ASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARH 727
+ S A+ + K ++ ++ + E L+ ++ + L + + E+
Sbjct: 1736 DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLT 1795
Query: 728 RELRA-------LESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEV 780
EL A ES QQ + I+ L G++ G ++ A + L+QA+ ++
Sbjct: 1796 TELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQL 1855
Query: 781 HQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLR--EHKTLVQQLKEQNEALN 838
Q +R+ + + +A+ R + E VL+ E + + QL++Q E N
Sbjct: 1856 EQETRERILSGKLVRRAEKR--------------LKEVVLQVEEERRVADQLRDQLEKGN 1901
Query: 839 RAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQL 898
L+ + + L EE +EA + + R LQ EL S+E E L+ +L
Sbjct: 1902 -------LRVKQLKRQL-EEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1953
Query: 899 HR 900
R
Sbjct: 1954 RR 1955
Score = 110 bits (275), Expect = 1e-23
Identities = 157/705 (22%), Positives = 288/705 (40%), Gaps = 90/705 (12%)
Query: 505 EQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPEL 564
++ +++ ++LQ ++ Q ++ V +L+ + QL +++ L++Q+ L
Sbjct: 876 DEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETR 935
Query: 565 PVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKE 624
+ + L V S L+ G+ EE R +Q ++++ L+Q +ELE
Sbjct: 936 GRLAARKQELELVVSELEARVGEEEECSRQMQ------------TEKKRLQQHIQELEAH 983
Query: 625 LQNVVGRNQLL-------EGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQM 677
L+ G Q L E K++ + D L+ + S + LE A +
Sbjct: 984 LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEE 1043
Query: 678 EASLLAVRKAKEAMKAQMAEKEAILQSKE--------------GECQQLREEVEQCQQLA 723
E + ++ K + +A +A+ E L+ +E GE +L+E++ + QQ A
Sbjct: 1044 EEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRA 1103
Query: 724 EARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQG 783
E ELRA + +++ Q ++G G RE A LA +Q LE +
Sbjct: 1104 E----ELRAQLGRKEEELQAALARAEDEG--GARAQLLKSLREAQAALAEAQEDLESERV 1157
Query: 784 EVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQ 843
+ + Q DL ++ A + + + + + + + V +LK+ E R H
Sbjct: 1158 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEA 1217
Query: 844 ELLQCSEREGALQEERADEAQQR--------------EEELRALQEELSQAKCSSEEAQL 889
+ + +R G E A++ +Q E E+ L+ ELS + + +E +
Sbjct: 1218 AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ 1277
Query: 890 EHAELQEQLHRANTDTAELGIQVCALTVEK-ERVEEALACAVQELQDAKEAASREREGLE 948
L+ QL + G + A EK +R + L L +A+ R + L
Sbjct: 1278 RRRRLELQLQEVQGRAGD-GERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELS 1336
Query: 949 RQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLA----QAEQRAQSLQEAAHQELNTLK 1004
A L +E LQE+ +A A + ++A+ A Q E+ A + +E A +EL T +
Sbjct: 1337 STEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEA-AARERAGRELQTAQ 1395
Query: 1005 FQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTS 1064
QLS R + EE+ L+A EEA + + ++L+ +
Sbjct: 1396 AQLS------------------EWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKT 1437
Query: 1065 NHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQE--------VTNR 1116
+ + R +E DLE+ Q++L K Q +++L E V R
Sbjct: 1438 ETVDRLERGRRRLQQELDDATMDLEQ-QRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER 1496
Query: 1117 ERND---QKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDAL 1158
ER + ++ A L R + +E EL R AL + +AL
Sbjct: 1497 ERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1541
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 156 bits (395), Expect = 1e-37
Identities = 257/998 (25%), Positives = 436/998 (43%), Gaps = 137/998 (13%)
Query: 238 ELDQLEVREK-QLRERMQQLDRENQELRAAVSQQGEQLQTERE--------RGRTAAEDN 288
EL Q RE +L+ R+ QL+ E L EQL+ E E RGR AA
Sbjct: 883 ELQQQSAREVGELQGRVAQLEEERARL-------AEQLRAEAELCAEAEETRGRLAARKQ 935
Query: 289 VRLTCLVAELQ----KQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALR----RL 340
L +V+EL+ ++ E ++ Q K LQ +Q LE E EE L+
Sbjct: 936 -ELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE-AHLEAEEGARQKLQLEKVTT 993
Query: 341 ESMLQPLAQELEATRDSLDKKNQ-------HLASFPGWLAMAQQKADTASDTKGRQEPIP 393
E+ ++ ++L D K ++ LA F A ++K + + + + E
Sbjct: 994 EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATI 1053
Query: 394 SDAAQEMQELGEKLQALERERTKVEEVNRQ---QSAQL-EQLVKELQLKEDARASLERLV 449
+D + ++L+ E+ R ++E++ R+ +S++L EQ+V++ Q E+ RA L R
Sbjct: 1054 AD-------MEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKE 1106
Query: 450 KEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVR 509
+E+ +G QL + L+E A + +E+L R + + ++++ L +E+
Sbjct: 1107 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELE 1166
Query: 510 SLTRQLQ-FLETQLAQV---SQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELP 565
+L +L+ L++ AQ S+ ++ E KK L ++ V L + G
Sbjct: 1167 ALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG------Q 1220
Query: 566 VAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQE---EELRQANRELE 622
GE E L + AW E+ R EA++ + + + S + +E Q R LE
Sbjct: 1221 ALGELAEQLEQARRG-KGAW----EKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE 1275
Query: 623 KELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASL-EAEQASIRHLGDQMEASL 681
+LQ V GR +G+ +A + LQ+ ++ ++ +L EAE +IR L ++ ++
Sbjct: 1276 LQLQEVQGRAG--DGERARAEA-AEKLQRAQAELENVSGALNEAESKTIR-LSKELSSTE 1331
Query: 682 LAVRKAKEAMKAQMAEKEAI---LQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQ 738
+ A+E ++ + K A+ +++ E E LRE++E+ E REL+ ++Q
Sbjct: 1332 AQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLS 1391
Query: 739 QQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGE-VQRLQAQVVDLQA 797
+ + E E G G EAR AA+ A + Q + E V RL+ LQ
Sbjct: 1392 EWRRRQE---EEAGALEAG----EEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQ 1444
Query: 798 KMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQE 857
++ A D ++ Q + + ++ + Q L E+ A+ R A++E
Sbjct: 1445 ELDDATMD---LEQQRQLVSTLEKKQRKFDQLLAEEKAAVLR--------------AVEE 1487
Query: 858 ERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTV 917
EA+ RE E RAL S A E E +E+L R N L ++ AL
Sbjct: 1488 RERAEAEGREREARAL---------SLTRALEEEQEAREELERQN---RALRAELEALLS 1535
Query: 918 EKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLP- 976
K+ V + +V EL+ A A + L QV L+++L AA+ A L
Sbjct: 1536 SKDDVGK----SVHELERACRVAEQAANDLRAQVT-------ELEDELTAAEDAKLRLEV 1584
Query: 977 GLQAQLAQAEQRAQSLQEAAHQELNTLKFQL-SAEIMDYQSRLKN--AGEECKSLRGQLE 1033
+QA Q E+ Q EA + L QL AE+ + R + A K L G+LE
Sbjct: 1585 TVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELE 1644
Query: 1034 EQGRQL----QAAEEAVEKLKATQADMGE---KLSCTSNHLAECQAAMLRKDKEGAALRE 1086
E Q+ Q EEAV++L+ QA M E ++ T E + +K L
Sbjct: 1645 ELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEA 1704
Query: 1087 DLERTQKEL---EKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIE 1143
++ R Q+EL ++A + Q+ +++ EV N + +L + L LEE L E
Sbjct: 1705 EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEE 1764
Query: 1144 LLRDKDALWQKSDALEFQ-----QKLSAEERWLGDTEA 1176
+ + L + L Q +LSAE + E+
Sbjct: 1765 EQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAES 1802
Score = 133 bits (334), Expect = 1e-30
Identities = 219/985 (22%), Positives = 402/985 (40%), Gaps = 153/985 (15%)
Query: 212 QEMVSNFDLNSPLNNEALEGFDEMRLELD----QLEVREKQLRERMQQLDRENQELRAAV 267
++ ++ F + E ++ +++RL+ + +E R ++ + Q+L++ + L
Sbjct: 1022 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1081
Query: 268 SQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAA 327
S+ EQ+ +++R A E +L ELQ + +L L+ + A
Sbjct: 1082 SELQEQMVEQQQR---AEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALA 1138
Query: 328 EKEEDYHT---ALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASD 384
E +ED + A + E + L +ELEA R L+ DT
Sbjct: 1139 EAQEDLESERVARTKAEKQRRDLGEELEALRGELE--------------------DTLDS 1178
Query: 385 TKGRQEPIPSDAAQEMQELGEKLQALER-ERTKVEEVNRQQSAQLEQLVKELQLK----- 438
T +QE + S QE+ EL + L+ R V+E+ ++ L +L ++L+
Sbjct: 1179 TNAQQE-LRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKG 1237
Query: 439 --EDARASLERLVKEMAPLQEELSGKGQEADQLWRRL----QELLAHTSSWEEELAELRR 492
E R +LE V E+ L QE +Q RRL QE+ E AE
Sbjct: 1238 AWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAE 1297
Query: 493 EKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGM 552
+ ++ Q E E + + + L +L+ + D +E ++ + K L +V
Sbjct: 1298 KLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRA 1357
Query: 553 LERLAGPPGPELPVAGEKNEA----LVPVNSSLQEAWGKPEEEQRGLQEA---------- 598
+E A +L E L + L E W + +EE+ G EA
Sbjct: 1358 MEAEAAGLREQLEEEAAARERAGRELQTAQAQLSE-WRRRQEEEAGALEAGEEARRRAAR 1416
Query: 599 ---QLDDTKVQEGSQEEELRQANRELEKELQNV---VGRNQLLEGKLQALQADY-QALQQ 651
L ++ + L + R L++EL + + + + L L+ Q + Q L +
Sbjct: 1417 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1476
Query: 652 RESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAM-----------KAQMAEKEA 700
++A+ ++ E +A G + EA L++ +A E +A AE EA
Sbjct: 1477 EKAAVLRAVEERERAEAE----GREREARALSLTRALEEEQEAREELERQNRALRAELEA 1532
Query: 701 ILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTA----------- 749
+L SK+ + + E +E+ ++AE +LRA Q T+L + LTA
Sbjct: 1533 LLSSKDDVGKSVHE-LERACRVAEQAANDLRA------QVTELEDELTAAEDAKLRLEVT 1585
Query: 750 --------EKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQR---------LQAQV 792
E+ QG + R+LA QL A++E + QR L+ ++
Sbjct: 1586 VQALKTQHERDLQGRDEAGEERRRQLAKQLR--DAEVERDEERKQRTLAVAARKKLEGEL 1643
Query: 793 VDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEAL---NRAHVQELLQCS 849
+L+A+M +A +++ QL +A ++E V++ + E + NR + L
Sbjct: 1644 EELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLE 1703
Query: 850 EREGALQEERAD------EAQQREEEL--RALQEELSQAKCSSEEAQLEH--AELQEQLH 899
LQEE A +AQQ +E+ LS+A E+ QLE +L+E+L
Sbjct: 1704 AEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELE 1763
Query: 900 RANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKE 959
+++ L + L ++ E + L+ + A R+ LERQ+ Q+ +
Sbjct: 1764 EEQSNSELLNDRYRKLLLQVESLTTELSAE----RSFSAKAESGRQQLERQI---QELRG 1816
Query: 960 SLQEKLKAAKAAAG-SLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRL 1018
L E+ A+A ++ L+++LAQAE++ E T + LS +++
Sbjct: 1817 RLGEEDAGARARHKMTIAALESKLAQAEEQL---------EQETRERILSGKLV------ 1861
Query: 1019 KNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKD 1078
+ A + K + Q+EE+ R + +EK + +L + QA R
Sbjct: 1862 RRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQ 1921
Query: 1079 KEGAALREDLERTQKELEKATTKIQ 1103
+E + E E +E+ +++
Sbjct: 1922 RELEDVTESAESMNREVTTLRNRLR 1946
Score = 130 bits (326), Expect = 1e-29
Identities = 232/965 (24%), Positives = 407/965 (42%), Gaps = 133/965 (13%)
Query: 219 DLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTER 278
D+ L E +G E+ +L+ +L+E+M + + +ELRA + ++ E+LQ
Sbjct: 1055 DMEDRLRKEE-KGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAAL 1113
Query: 279 ERGRTAAEDNVRLT-------CLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKE- 330
R +L +AE Q+ E ++ T E Q G EL A E
Sbjct: 1114 ARAEDEGGARAQLLKSLREAQAALAEAQEDLE-SERVARTKAEKQRRDLGEELEALRGEL 1172
Query: 331 EDYHTALRRLESMLQPLAQELEATRDSLDKKN-------QHLASFPGW-LAMAQQKADTA 382
ED + + + QE+ + +L+++ Q L G L ++ + A
Sbjct: 1173 EDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQA 1232
Query: 383 SDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDAR 442
KG E E+ EL +L +L+ R + E+ R+ QL+++ E AR
Sbjct: 1233 RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERAR 1292
Query: 443 A-SLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQ--- 498
A + E+L + A L E +SG EA+ RL + L+ T + + EL +E+ + +
Sbjct: 1293 AEAAEKLQRAQAEL-ENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL 1351
Query: 499 -EEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLA 557
+E E L Q LE + A + +L+ + QL + + ++ G LE A
Sbjct: 1352 GSRVRAMEAEAAGLREQ---LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE--A 1406
Query: 558 GPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQA 617
G A + EAL + E + E +R LQ+ +LDD + E+ RQ
Sbjct: 1407 GEEARRR--AAREAEALTQRLAEKTETVDRLERGRRRLQQ-ELDDATM----DLEQQRQL 1459
Query: 618 NRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASI-RHLGDQ 676
LEK+ + +QLL + A+ +A+++RE A + EA S+ R L ++
Sbjct: 1460 VSTLEKKQRKF---DQLLAEEKAAV---LRAVEERERA-EAEGREREARALSLTRALEEE 1512
Query: 677 MEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ 736
EA + + +A AE EA+L SK+ + + E+E+ ++AE +LRA
Sbjct: 1513 QEAR----EELERQNRALRAELEALLSSKDDVGKSV-HELERACRVAEQAANDLRA---- 1563
Query: 737 CQQQTQLIEVLTA-------------------EKGQQGVGPPTDNEARELAAQLALSQAQ 777
Q T+L + LTA E+ QG + R+LA Q L A+
Sbjct: 1564 --QVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQ--LRDAE 1619
Query: 778 LEVHQGEVQR---------LQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQ 828
+E + QR L+ ++ +L+A+M +A +++ QL +A ++E V+
Sbjct: 1620 VERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVE 1679
Query: 829 QLKEQNEAL---NRAHVQELLQCSEREGALQEERA------DEAQQREEEL--RALQEEL 877
+ + E + NR + L LQEE A +AQQ +E+ L
Sbjct: 1680 ETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNL 1739
Query: 878 SQAKCSSEEAQLEH--AELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQD 935
S+A E+ QLE +L+E+L +++ L + L ++ E + L+ +
Sbjct: 1740 SKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAE----RS 1795
Query: 936 AKEAASREREGLERQVAGLQQEKESLQEKLKAAKAA-AGSLPGLQAQLAQAEQRAQ---- 990
A R+ LERQ+ Q+ + L E+ A+A ++ L+++LAQAE++ +
Sbjct: 1796 FSAKAESGRQQLERQI---QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETR 1852
Query: 991 ------SLQEAAHQELNTLKFQLSAE--IMD-YQSRLKNAGEECKSLRGQLEEQGRQLQA 1041
L A + L + Q+ E + D + +L+ K L+ QLEE +
Sbjct: 1853 ERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASR 1912
Query: 1042 AEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLR--------------KDKEGAALRED 1087
A+ +L+ D+ E + + + + R + +EG A E+
Sbjct: 1913 AQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEE 1972
Query: 1088 LERTQ 1092
E Q
Sbjct: 1973 AEEAQ 1977
Score = 118 bits (295), Expect = 5e-26
Identities = 190/781 (24%), Positives = 324/781 (41%), Gaps = 92/781 (11%)
Query: 396 AAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPL 455
A Q+ Q+ L+ ++R ++ Q +L VK L L+ +E+ +
Sbjct: 822 AFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQELQKV 881
Query: 456 QEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQL 515
QE +E +L R+ +L EEE A L + + + E E+ L +
Sbjct: 882 QELQQQSAREVGELQGRVAQL-------EEERARLAEQLRAEAELCAEAEETRGRLAARK 934
Query: 516 QFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLE-RLAGPPGPELPVAGEK--NE 572
Q LE ++++ V + EE +Q+ +K L Q + LE L G + EK E
Sbjct: 935 QELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTE 994
Query: 573 ALV---PVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQAN----------- 618
A + + L E ++R L E +L + Q +EE+++ N
Sbjct: 995 AKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIA 1054
Query: 619 ------RELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAE-QASIR 671
R+ EK Q + + L+G+ LQ QQR ++ L E E QA++
Sbjct: 1055 DMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALA 1114
Query: 672 HLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVE-QCQQLAEARHREL 730
D+ A ++ +EA +A +AE + L+S+ + R + E Q + L E EL
Sbjct: 1115 RAEDEGGARAQLLKSLREA-QAALAEAQEDLESE----RVARTKAEKQRRDLGE----EL 1165
Query: 731 RALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQ- 789
AL +L + L + QQ + + E EL L + + +H+ VQ L+
Sbjct: 1166 EALRG------ELEDTLDSTNAQQELRSKREQEVTELKKTL---EEETRIHEAAVQELRQ 1216
Query: 790 ------AQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQ 843
++ + + R +K + L + LR + +Q +++ E R
Sbjct: 1217 RHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLEL 1276
Query: 844 ELLQCSEREGALQEERADEA---QQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHR 900
+L + R G + RA+ A Q+ + EL + L++A+ + E + + QLH
Sbjct: 1277 QLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHD 1336
Query: 901 ANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQ----- 955
A E AL + R EA A ++E Q +EAA+RER G E Q A Q
Sbjct: 1337 AQELLQEETRAKLALG-SRVRAMEAEAAGLRE-QLEEEAAARERAGRELQTAQAQLSEWR 1394
Query: 956 --QEKE--SLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEA---AHQELNTLKFQLS 1008
QE+E +L+ +A + AA L +LA+ + L+ QEL+ L
Sbjct: 1395 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL- 1453
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQL--EEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNH 1066
+ Q +L + E+ + QL EE+ L+A EE E+ +A + + +
Sbjct: 1454 ----EQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER-ERAEAEGREREARALSLTRA 1508
Query: 1067 LAECQAAMLRKDKEGAALREDLE----------RTQKELEKATTKIQEYYNKLCQEVTNR 1116
L E Q A +++ ALR +LE ++ ELE+A ++ N L +VT
Sbjct: 1509 LEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTEL 1568
Query: 1117 E 1117
E
Sbjct: 1569 E 1569
Score = 111 bits (278), Expect = 5e-24
Identities = 168/722 (23%), Positives = 299/722 (41%), Gaps = 80/722 (11%)
Query: 209 LQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVS 268
LQ QE+ EA E + EL+ + + + +L +E A +
Sbjct: 1276 LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH 1335
Query: 269 QQGEQLQTERERGRTAAEDNVR-LTCLVAELQKQWEVTQATQNTV-KELQTCLQGL---- 322
E LQ E R + A VR + A L++Q E A + +ELQT L
Sbjct: 1336 DAQELLQ-EETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWR 1394
Query: 323 -----ELGAAEK-EEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQ 376
E GA E EE A R E++ Q LA++ E T D L++ + L Q
Sbjct: 1395 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTE-TVDRLERGRRRL----------Q 1443
Query: 377 QKADTASDTKGRQEPIPSDAAQEM----QELGEKLQALER---ERTKVEEVNRQQSAQLE 429
Q+ D A+ +Q + S ++ Q L E+ A+ R ER + E R++ A+
Sbjct: 1444 QELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1503
Query: 430 QLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAE 489
L + L+ +++AR LER + L+ EL D + + + EL E+ +
Sbjct: 1504 SLTRALEEEQEAREELER---QNRALRAELEALLSSKDDVGKSVHELERACRVAEQAAND 1560
Query: 490 LRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQ 549
LR + + ++E E L +Q L+T QH DL+ + + + + L++Q
Sbjct: 1561 LRAQVTELEDELTAAEDAKLRLEVTVQALKT------QHERDLQGRDEAGEERRRQLAKQ 1614
Query: 550 V--GMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQE 607
+ +ER L VA K + L+E + +G +EA K+Q
Sbjct: 1615 LRDAEVERDEERKQRTLAVAARKK-----LEGELEELKAQMASAGQGKEEAVKQLRKMQ- 1668
Query: 608 GSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQ 667
+Q +EL + E + + +N+ E +L+ L+A+ LQ+ +A + + ++
Sbjct: 1669 -AQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDR 1727
Query: 668 ASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARH 727
+ S A+ + K ++ ++ + E L+ ++ + L + + E+
Sbjct: 1728 DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLT 1787
Query: 728 RELRA-------LESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEV 780
EL A ES QQ + I+ L G++ G ++ A + L+QA+ ++
Sbjct: 1788 TELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQL 1847
Query: 781 HQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLR--EHKTLVQQLKEQNEALN 838
Q +R+ + + +A+ R + E VL+ E + + QL++Q E N
Sbjct: 1848 EQETRERILSGKLVRRAEKR--------------LKEVVLQVEEERRVADQLRDQLEKGN 1893
Query: 839 RAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQL 898
L+ + + L EE +EA + + R LQ EL S+E E L+ +L
Sbjct: 1894 -------LRVKQLKRQL-EEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1945
Query: 899 HR 900
R
Sbjct: 1946 RR 1947
Score = 110 bits (275), Expect = 1e-23
Identities = 157/705 (22%), Positives = 288/705 (40%), Gaps = 90/705 (12%)
Query: 505 EQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPEL 564
++ +++ ++LQ ++ Q ++ V +L+ + QL +++ L++Q+ L
Sbjct: 868 DEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETR 927
Query: 565 PVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKE 624
+ + L V S L+ G+ EE R +Q ++++ L+Q +ELE
Sbjct: 928 GRLAARKQELELVVSELEARVGEEEECSRQMQ------------TEKKRLQQHIQELEAH 975
Query: 625 LQNVVGRNQLL-------EGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQM 677
L+ G Q L E K++ + D L+ + S + LE A +
Sbjct: 976 LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEE 1035
Query: 678 EASLLAVRKAKEAMKAQMAEKEAILQSKE--------------GECQQLREEVEQCQQLA 723
E + ++ K + +A +A+ E L+ +E GE +L+E++ + QQ A
Sbjct: 1036 EEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRA 1095
Query: 724 EARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQG 783
E ELRA + +++ Q ++G G RE A LA +Q LE +
Sbjct: 1096 E----ELRAQLGRKEEELQAALARAEDEG--GARAQLLKSLREAQAALAEAQEDLESERV 1149
Query: 784 EVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQ 843
+ + Q DL ++ A + + + + + + + V +LK+ E R H
Sbjct: 1150 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEA 1209
Query: 844 ELLQCSEREGALQEERADEAQQR--------------EEELRALQEELSQAKCSSEEAQL 889
+ + +R G E A++ +Q E E+ L+ ELS + + +E +
Sbjct: 1210 AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ 1269
Query: 890 EHAELQEQLHRANTDTAELGIQVCALTVEK-ERVEEALACAVQELQDAKEAASREREGLE 948
L+ QL + G + A EK +R + L L +A+ R + L
Sbjct: 1270 RRRRLELQLQEVQGRAGD-GERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELS 1328
Query: 949 RQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLA----QAEQRAQSLQEAAHQELNTLK 1004
A L +E LQE+ +A A + ++A+ A Q E+ A + +E A +EL T +
Sbjct: 1329 STEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEA-AARERAGRELQTAQ 1387
Query: 1005 FQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTS 1064
QLS R + EE+ L+A EEA + + ++L+ +
Sbjct: 1388 AQLS------------------EWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKT 1429
Query: 1065 NHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQE--------VTNR 1116
+ + R +E DLE+ Q++L K Q +++L E V R
Sbjct: 1430 ETVDRLERGRRRLQQELDDATMDLEQ-QRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER 1488
Query: 1117 ERND---QKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDAL 1158
ER + ++ A L R + +E EL R AL + +AL
Sbjct: 1489 ERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1533
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 156 bits (395), Expect = 1e-37
Identities = 257/998 (25%), Positives = 436/998 (43%), Gaps = 137/998 (13%)
Query: 238 ELDQLEVREK-QLRERMQQLDRENQELRAAVSQQGEQLQTERE--------RGRTAAEDN 288
EL Q RE +L+ R+ QL+ E L EQL+ E E RGR AA
Sbjct: 924 ELQQQSAREVGELQGRVAQLEEERARL-------AEQLRAEAELCAEAEETRGRLAARKQ 976
Query: 289 VRLTCLVAELQ----KQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALR----RL 340
L +V+EL+ ++ E ++ Q K LQ +Q LE E EE L+
Sbjct: 977 -ELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE-AHLEAEEGARQKLQLEKVTT 1034
Query: 341 ESMLQPLAQELEATRDSLDKKNQ-------HLASFPGWLAMAQQKADTASDTKGRQEPIP 393
E+ ++ ++L D K ++ LA F A ++K + + + + E
Sbjct: 1035 EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATI 1094
Query: 394 SDAAQEMQELGEKLQALERERTKVEEVNRQ---QSAQL-EQLVKELQLKEDARASLERLV 449
+D + ++L+ E+ R ++E++ R+ +S++L EQ+V++ Q E+ RA L R
Sbjct: 1095 AD-------MEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKE 1147
Query: 450 KEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVR 509
+E+ +G QL + L+E A + +E+L R + + ++++ L +E+
Sbjct: 1148 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELE 1207
Query: 510 SLTRQLQ-FLETQLAQV---SQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELP 565
+L +L+ L++ AQ S+ ++ E KK L ++ V L + G
Sbjct: 1208 ALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG------Q 1261
Query: 566 VAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQE---EELRQANRELE 622
GE E L + AW E+ R EA++ + + + S + +E Q R LE
Sbjct: 1262 ALGELAEQLEQARRG-KGAW----EKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE 1316
Query: 623 KELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASL-EAEQASIRHLGDQMEASL 681
+LQ V GR +G+ +A + LQ+ ++ ++ +L EAE +IR L ++ ++
Sbjct: 1317 LQLQEVQGRAG--DGERARAEA-AEKLQRAQAELENVSGALNEAESKTIR-LSKELSSTE 1372
Query: 682 LAVRKAKEAMKAQMAEKEAI---LQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQ 738
+ A+E ++ + K A+ +++ E E LRE++E+ E REL+ ++Q
Sbjct: 1373 AQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLS 1432
Query: 739 QQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGE-VQRLQAQVVDLQA 797
+ + E E G G EAR AA+ A + Q + E V RL+ LQ
Sbjct: 1433 EWRRRQE---EEAGALEAG----EEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQ 1485
Query: 798 KMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQE 857
++ A D ++ Q + + ++ + Q L E+ A+ R A++E
Sbjct: 1486 ELDDATMD---LEQQRQLVSTLEKKQRKFDQLLAEEKAAVLR--------------AVEE 1528
Query: 858 ERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTV 917
EA+ RE E RAL S A E E +E+L R N L ++ AL
Sbjct: 1529 RERAEAEGREREARAL---------SLTRALEEEQEAREELERQN---RALRAELEALLS 1576
Query: 918 EKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLP- 976
K+ V + +V EL+ A A + L QV L+++L AA+ A L
Sbjct: 1577 SKDDVGK----SVHELERACRVAEQAANDLRAQVT-------ELEDELTAAEDAKLRLEV 1625
Query: 977 GLQAQLAQAEQRAQSLQEAAHQELNTLKFQL-SAEIMDYQSRLKN--AGEECKSLRGQLE 1033
+QA Q E+ Q EA + L QL AE+ + R + A K L G+LE
Sbjct: 1626 TVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELE 1685
Query: 1034 EQGRQL----QAAEEAVEKLKATQADMGE---KLSCTSNHLAECQAAMLRKDKEGAALRE 1086
E Q+ Q EEAV++L+ QA M E ++ T E + +K L
Sbjct: 1686 ELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEA 1745
Query: 1087 DLERTQKEL---EKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIE 1143
++ R Q+EL ++A + Q+ +++ EV N + +L + L LEE L E
Sbjct: 1746 EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEE 1805
Query: 1144 LLRDKDALWQKSDALEFQ-----QKLSAEERWLGDTEA 1176
+ + L + L Q +LSAE + E+
Sbjct: 1806 EQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAES 1843
Score = 133 bits (334), Expect = 1e-30
Identities = 219/985 (22%), Positives = 402/985 (40%), Gaps = 153/985 (15%)
Query: 212 QEMVSNFDLNSPLNNEALEGFDEMRLELD----QLEVREKQLRERMQQLDRENQELRAAV 267
++ ++ F + E ++ +++RL+ + +E R ++ + Q+L++ + L
Sbjct: 1063 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1122
Query: 268 SQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAA 327
S+ EQ+ +++R A E +L ELQ + +L L+ + A
Sbjct: 1123 SELQEQMVEQQQR---AEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALA 1179
Query: 328 EKEEDYHT---ALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASD 384
E +ED + A + E + L +ELEA R L+ DT
Sbjct: 1180 EAQEDLESERVARTKAEKQRRDLGEELEALRGELE--------------------DTLDS 1219
Query: 385 TKGRQEPIPSDAAQEMQELGEKLQALER-ERTKVEEVNRQQSAQLEQLVKELQLK----- 438
T +QE + S QE+ EL + L+ R V+E+ ++ L +L ++L+
Sbjct: 1220 TNAQQE-LRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKG 1278
Query: 439 --EDARASLERLVKEMAPLQEELSGKGQEADQLWRRL----QELLAHTSSWEEELAELRR 492
E R +LE V E+ L QE +Q RRL QE+ E AE
Sbjct: 1279 AWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAE 1338
Query: 493 EKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGM 552
+ ++ Q E E + + + L +L+ + D +E ++ + K L +V
Sbjct: 1339 KLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRA 1398
Query: 553 LERLAGPPGPELPVAGEKNEA----LVPVNSSLQEAWGKPEEEQRGLQEA---------- 598
+E A +L E L + L E W + +EE+ G EA
Sbjct: 1399 MEAEAAGLREQLEEEAAARERAGRELQTAQAQLSE-WRRRQEEEAGALEAGEEARRRAAR 1457
Query: 599 ---QLDDTKVQEGSQEEELRQANRELEKELQNV---VGRNQLLEGKLQALQADY-QALQQ 651
L ++ + L + R L++EL + + + + L L+ Q + Q L +
Sbjct: 1458 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1517
Query: 652 RESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAM-----------KAQMAEKEA 700
++A+ ++ E +A G + EA L++ +A E +A AE EA
Sbjct: 1518 EKAAVLRAVEERERAEAE----GREREARALSLTRALEEEQEAREELERQNRALRAELEA 1573
Query: 701 ILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTA----------- 749
+L SK+ + + E +E+ ++AE +LRA Q T+L + LTA
Sbjct: 1574 LLSSKDDVGKSVHE-LERACRVAEQAANDLRA------QVTELEDELTAAEDAKLRLEVT 1626
Query: 750 --------EKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQR---------LQAQV 792
E+ QG + R+LA QL A++E + QR L+ ++
Sbjct: 1627 VQALKTQHERDLQGRDEAGEERRRQLAKQLR--DAEVERDEERKQRTLAVAARKKLEGEL 1684
Query: 793 VDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEAL---NRAHVQELLQCS 849
+L+A+M +A +++ QL +A ++E V++ + E + NR + L
Sbjct: 1685 EELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLE 1744
Query: 850 EREGALQEERAD------EAQQREEEL--RALQEELSQAKCSSEEAQLEH--AELQEQLH 899
LQEE A +AQQ +E+ LS+A E+ QLE +L+E+L
Sbjct: 1745 AEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELE 1804
Query: 900 RANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKE 959
+++ L + L ++ E + L+ + A R+ LERQ+ Q+ +
Sbjct: 1805 EEQSNSELLNDRYRKLLLQVESLTTELSAE----RSFSAKAESGRQQLERQI---QELRG 1857
Query: 960 SLQEKLKAAKAAAG-SLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRL 1018
L E+ A+A ++ L+++LAQAE++ E T + LS +++
Sbjct: 1858 RLGEEDAGARARHKMTIAALESKLAQAEEQL---------EQETRERILSGKLV------ 1902
Query: 1019 KNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKD 1078
+ A + K + Q+EE+ R + +EK + +L + QA R
Sbjct: 1903 RRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQ 1962
Query: 1079 KEGAALREDLERTQKELEKATTKIQ 1103
+E + E E +E+ +++
Sbjct: 1963 RELEDVTESAESMNREVTTLRNRLR 1987
Score = 130 bits (326), Expect = 1e-29
Identities = 232/965 (24%), Positives = 407/965 (42%), Gaps = 133/965 (13%)
Query: 219 DLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTER 278
D+ L E +G E+ +L+ +L+E+M + + +ELRA + ++ E+LQ
Sbjct: 1096 DMEDRLRKEE-KGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAAL 1154
Query: 279 ERGRTAAEDNVRLT-------CLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKE- 330
R +L +AE Q+ E ++ T E Q G EL A E
Sbjct: 1155 ARAEDEGGARAQLLKSLREAQAALAEAQEDLE-SERVARTKAEKQRRDLGEELEALRGEL 1213
Query: 331 EDYHTALRRLESMLQPLAQELEATRDSLDKKN-------QHLASFPGW-LAMAQQKADTA 382
ED + + + QE+ + +L+++ Q L G L ++ + A
Sbjct: 1214 EDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQA 1273
Query: 383 SDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDAR 442
KG E E+ EL +L +L+ R + E+ R+ QL+++ E AR
Sbjct: 1274 RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERAR 1333
Query: 443 A-SLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQ--- 498
A + E+L + A L E +SG EA+ RL + L+ T + + EL +E+ + +
Sbjct: 1334 AEAAEKLQRAQAEL-ENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL 1392
Query: 499 -EEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLA 557
+E E L Q LE + A + +L+ + QL + + ++ G LE A
Sbjct: 1393 GSRVRAMEAEAAGLREQ---LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE--A 1447
Query: 558 GPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQA 617
G A + EAL + E + E +R LQ+ +LDD + E+ RQ
Sbjct: 1448 GEEARRR--AAREAEALTQRLAEKTETVDRLERGRRRLQQ-ELDDATM----DLEQQRQL 1500
Query: 618 NRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASI-RHLGDQ 676
LEK+ + +QLL + A+ +A+++RE A + EA S+ R L ++
Sbjct: 1501 VSTLEKKQRKF---DQLLAEEKAAV---LRAVEERERA-EAEGREREARALSLTRALEEE 1553
Query: 677 MEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ 736
EA + + +A AE EA+L SK+ + + E+E+ ++AE +LRA
Sbjct: 1554 QEAR----EELERQNRALRAELEALLSSKDDVGKSV-HELERACRVAEQAANDLRA---- 1604
Query: 737 CQQQTQLIEVLTA-------------------EKGQQGVGPPTDNEARELAAQLALSQAQ 777
Q T+L + LTA E+ QG + R+LA Q L A+
Sbjct: 1605 --QVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQ--LRDAE 1660
Query: 778 LEVHQGEVQR---------LQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQ 828
+E + QR L+ ++ +L+A+M +A +++ QL +A ++E V+
Sbjct: 1661 VERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVE 1720
Query: 829 QLKEQNEAL---NRAHVQELLQCSEREGALQEERA------DEAQQREEEL--RALQEEL 877
+ + E + NR + L LQEE A +AQQ +E+ L
Sbjct: 1721 ETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNL 1780
Query: 878 SQAKCSSEEAQLEH--AELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQD 935
S+A E+ QLE +L+E+L +++ L + L ++ E + L+ +
Sbjct: 1781 SKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAE----RS 1836
Query: 936 AKEAASREREGLERQVAGLQQEKESLQEKLKAAKAA-AGSLPGLQAQLAQAEQRAQ---- 990
A R+ LERQ+ Q+ + L E+ A+A ++ L+++LAQAE++ +
Sbjct: 1837 FSAKAESGRQQLERQI---QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETR 1893
Query: 991 ------SLQEAAHQELNTLKFQLSAE--IMD-YQSRLKNAGEECKSLRGQLEEQGRQLQA 1041
L A + L + Q+ E + D + +L+ K L+ QLEE +
Sbjct: 1894 ERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASR 1953
Query: 1042 AEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLR--------------KDKEGAALRED 1087
A+ +L+ D+ E + + + + R + +EG A E+
Sbjct: 1954 AQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEE 2013
Query: 1088 LERTQ 1092
E Q
Sbjct: 2014 AEEAQ 2018
Score = 118 bits (295), Expect = 5e-26
Identities = 190/781 (24%), Positives = 324/781 (41%), Gaps = 92/781 (11%)
Query: 396 AAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPL 455
A Q+ Q+ L+ ++R ++ Q +L VK L L+ +E+ +
Sbjct: 863 AFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQELQKV 922
Query: 456 QEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQL 515
QE +E +L R+ +L EEE A L + + + E E+ L +
Sbjct: 923 QELQQQSAREVGELQGRVAQL-------EEERARLAEQLRAEAELCAEAEETRGRLAARK 975
Query: 516 QFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLE-RLAGPPGPELPVAGEK--NE 572
Q LE ++++ V + EE +Q+ +K L Q + LE L G + EK E
Sbjct: 976 QELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTE 1035
Query: 573 ALV---PVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQAN----------- 618
A + + L E ++R L E +L + Q +EE+++ N
Sbjct: 1036 AKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIA 1095
Query: 619 ------RELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAE-QASIR 671
R+ EK Q + + L+G+ LQ QQR ++ L E E QA++
Sbjct: 1096 DMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALA 1155
Query: 672 HLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVE-QCQQLAEARHREL 730
D+ A ++ +EA +A +AE + L+S+ + R + E Q + L E EL
Sbjct: 1156 RAEDEGGARAQLLKSLREA-QAALAEAQEDLESE----RVARTKAEKQRRDLGE----EL 1206
Query: 731 RALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQ- 789
AL +L + L + QQ + + E EL L + + +H+ VQ L+
Sbjct: 1207 EALRG------ELEDTLDSTNAQQELRSKREQEVTELKKTL---EEETRIHEAAVQELRQ 1257
Query: 790 ------AQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQ 843
++ + + R +K + L + LR + +Q +++ E R
Sbjct: 1258 RHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLEL 1317
Query: 844 ELLQCSEREGALQEERADEA---QQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHR 900
+L + R G + RA+ A Q+ + EL + L++A+ + E + + QLH
Sbjct: 1318 QLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHD 1377
Query: 901 ANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQ----- 955
A E AL + R EA A ++E Q +EAA+RER G E Q A Q
Sbjct: 1378 AQELLQEETRAKLALG-SRVRAMEAEAAGLRE-QLEEEAAARERAGRELQTAQAQLSEWR 1435
Query: 956 --QEKE--SLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEA---AHQELNTLKFQLS 1008
QE+E +L+ +A + AA L +LA+ + L+ QEL+ L
Sbjct: 1436 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL- 1494
Query: 1009 AEIMDYQSRLKNAGEECKSLRGQL--EEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNH 1066
+ Q +L + E+ + QL EE+ L+A EE E+ +A + + +
Sbjct: 1495 ----EQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER-ERAEAEGREREARALSLTRA 1549
Query: 1067 LAECQAAMLRKDKEGAALREDLE----------RTQKELEKATTKIQEYYNKLCQEVTNR 1116
L E Q A +++ ALR +LE ++ ELE+A ++ N L +VT
Sbjct: 1550 LEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTEL 1609
Query: 1117 E 1117
E
Sbjct: 1610 E 1610
Score = 111 bits (278), Expect = 5e-24
Identities = 168/722 (23%), Positives = 299/722 (41%), Gaps = 80/722 (11%)
Query: 209 LQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVS 268
LQ QE+ EA E + EL+ + + + +L +E A +
Sbjct: 1317 LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH 1376
Query: 269 QQGEQLQTERERGRTAAEDNVR-LTCLVAELQKQWEVTQATQNTV-KELQTCLQGL---- 322
E LQ E R + A VR + A L++Q E A + +ELQT L
Sbjct: 1377 DAQELLQ-EETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWR 1435
Query: 323 -----ELGAAEK-EEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQ 376
E GA E EE A R E++ Q LA++ E T D L++ + L Q
Sbjct: 1436 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTE-TVDRLERGRRRL----------Q 1484
Query: 377 QKADTASDTKGRQEPIPSDAAQEM----QELGEKLQALER---ERTKVEEVNRQQSAQLE 429
Q+ D A+ +Q + S ++ Q L E+ A+ R ER + E R++ A+
Sbjct: 1485 QELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1544
Query: 430 QLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAE 489
L + L+ +++AR LER + L+ EL D + + + EL E+ +
Sbjct: 1545 SLTRALEEEQEAREELER---QNRALRAELEALLSSKDDVGKSVHELERACRVAEQAAND 1601
Query: 490 LRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQ 549
LR + + ++E E L +Q L+T QH DL+ + + + + L++Q
Sbjct: 1602 LRAQVTELEDELTAAEDAKLRLEVTVQALKT------QHERDLQGRDEAGEERRRQLAKQ 1655
Query: 550 V--GMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQE 607
+ +ER L VA K + L+E + +G +EA K+Q
Sbjct: 1656 LRDAEVERDEERKQRTLAVAARKK-----LEGELEELKAQMASAGQGKEEAVKQLRKMQ- 1709
Query: 608 GSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQ 667
+Q +EL + E + + +N+ E +L+ L+A+ LQ+ +A + + ++
Sbjct: 1710 -AQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDR 1768
Query: 668 ASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARH 727
+ S A+ + K ++ ++ + E L+ ++ + L + + E+
Sbjct: 1769 DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLT 1828
Query: 728 RELRA-------LESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEV 780
EL A ES QQ + I+ L G++ G ++ A + L+QA+ ++
Sbjct: 1829 TELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQL 1888
Query: 781 HQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLR--EHKTLVQQLKEQNEALN 838
Q +R+ + + +A+ R + E VL+ E + + QL++Q E N
Sbjct: 1889 EQETRERILSGKLVRRAEKR--------------LKEVVLQVEEERRVADQLRDQLEKGN 1934
Query: 839 RAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQL 898
L+ + + L EE +EA + + R LQ EL S+E E L+ +L
Sbjct: 1935 -------LRVKQLKRQL-EEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1986
Query: 899 HR 900
R
Sbjct: 1987 RR 1988
Score = 110 bits (275), Expect = 1e-23
Identities = 157/705 (22%), Positives = 288/705 (40%), Gaps = 90/705 (12%)
Query: 505 EQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPEL 564
++ +++ ++LQ ++ Q ++ V +L+ + QL +++ L++Q+ L
Sbjct: 909 DEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETR 968
Query: 565 PVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKE 624
+ + L V S L+ G+ EE R +Q ++++ L+Q +ELE
Sbjct: 969 GRLAARKQELELVVSELEARVGEEEECSRQMQ------------TEKKRLQQHIQELEAH 1016
Query: 625 LQNVVGRNQLL-------EGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQM 677
L+ G Q L E K++ + D L+ + S + LE A +
Sbjct: 1017 LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEE 1076
Query: 678 EASLLAVRKAKEAMKAQMAEKEAILQSKE--------------GECQQLREEVEQCQQLA 723
E + ++ K + +A +A+ E L+ +E GE +L+E++ + QQ A
Sbjct: 1077 EEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRA 1136
Query: 724 EARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQG 783
E ELRA + +++ Q ++G G RE A LA +Q LE +
Sbjct: 1137 E----ELRAQLGRKEEELQAALARAEDEG--GARAQLLKSLREAQAALAEAQEDLESERV 1190
Query: 784 EVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQ 843
+ + Q DL ++ A + + + + + + + V +LK+ E R H
Sbjct: 1191 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEA 1250
Query: 844 ELLQCSEREGALQEERADEAQQR--------------EEELRALQEELSQAKCSSEEAQL 889
+ + +R G E A++ +Q E E+ L+ ELS + + +E +
Sbjct: 1251 AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ 1310
Query: 890 EHAELQEQLHRANTDTAELGIQVCALTVEK-ERVEEALACAVQELQDAKEAASREREGLE 948
L+ QL + G + A EK +R + L L +A+ R + L
Sbjct: 1311 RRRRLELQLQEVQGRAGD-GERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELS 1369
Query: 949 RQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLA----QAEQRAQSLQEAAHQELNTLK 1004
A L +E LQE+ +A A + ++A+ A Q E+ A + +E A +EL T +
Sbjct: 1370 STEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEA-AARERAGRELQTAQ 1428
Query: 1005 FQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTS 1064
QLS R + EE+ L+A EEA + + ++L+ +
Sbjct: 1429 AQLS------------------EWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKT 1470
Query: 1065 NHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQE--------VTNR 1116
+ + R +E DLE+ Q++L K Q +++L E V R
Sbjct: 1471 ETVDRLERGRRRLQQELDDATMDLEQ-QRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER 1529
Query: 1117 ERND---QKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDAL 1158
ER + ++ A L R + +E EL R AL + +AL
Sbjct: 1530 ERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1574
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 154 bits (389), Expect = 6e-37
Identities = 235/979 (24%), Positives = 407/979 (41%), Gaps = 146/979 (14%)
Query: 202 SSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQ 261
+SL S ++ E +++ L S L L+ E + E + L+ ++ L +++ L
Sbjct: 1309 NSLESELMELHETMAS--LQSRLRRAELQRM-EAQGERELLQAAKENLTAQVEHLQAAVV 1365
Query: 262 ELRAAVSQQG---EQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTC 318
E RA S G E L+T R + E+ LQ+Q E+ A K LQ
Sbjct: 1366 EARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQG---KALQEN 1422
Query: 319 LQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQK 378
L L AE+EE+ T L +Q L ++ E + +L+ + L + + Q++
Sbjct: 1423 LALLTQTLAEREEEVET----LRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQ 1478
Query: 379 ADTASDTKGRQEPIPSDAAQEMQELG---EKLQALERERTKVEEVNRQQSAQLEQLVKEL 435
+ E +P + Q+L E+++ LE++R V Q +LE K+
Sbjct: 1479 IQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELE---KKD 1535
Query: 436 QLKEDARASLERLVKEMAPLQ---EELSGKGQEADQLWRRLQELLAHTSSWEEELAELRR 492
Q+ E R ++ L K++ L+ EL + + + ++EL + L L
Sbjct: 1536 QMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTL 1595
Query: 493 EKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGM 552
+ +++ +E + ++ L L +L + Q V EQ ++L + K+HL+Q
Sbjct: 1596 DLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQD--- 1652
Query: 553 LERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEE 612
LER EL + E+ + L E+QR Q TK+ E E+
Sbjct: 1653 LER----RDQELMLQKERIQVL---------------EDQRTRQ------TKILEEDLEQ 1687
Query: 613 ---ELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQAS 669
LR+ REL + Q + R + EGK + +A +L+ + ++ +E +Q
Sbjct: 1688 IKLSLRERGRELTTQRQLMQERAE--EGKGPS-KAQRGSLEHMKLILRDKEKEVECQQEH 1744
Query: 670 I---RHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEAR 726
I + L DQ+E L + + ++ E +L +E E L++++++ ++ E +
Sbjct: 1745 IHELQELKDQLEQQL-------QGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELK 1797
Query: 727 HRELRALESQCQ----QQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQ--LEV 780
+ L++ + Q Q+ Q +E L E+ QQ G + + A Q AL QA L+
Sbjct: 1798 EQSLQSQLDEAQRALAQRDQELEALQQEQ-QQAQGQEERVKEKADALQGALEQAHMTLKE 1856
Query: 781 HQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHK----TLVQQLKEQ--- 833
GE+Q + Q L+ ++ ++ L A RE + L QQ EQ
Sbjct: 1857 RHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQE 1916
Query: 834 ----NEALNRAHVQELLQCSEREGALQEERADEAQQREEE------LRALQEELSQAKCS 883
AL + +Q ER+ L+ RA+ R +E ALQE L +A +
Sbjct: 1917 HEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAA 1976
Query: 884 ---SEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAA 940
E+ LE AEL L A+T T + + C ++EEAL E+QD
Sbjct: 1977 LQGKEQHLLEQAELSRSL-EASTATLQASLDAC--QAHSRQLEEALRIQEGEIQDQDLRY 2033
Query: 941 SREREGLERQVAGL------QQEKESLQEKLKAAKAAAG--------------------- 973
+ + L++ +A QQE+E L EK A +
Sbjct: 2034 QEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLH 2093
Query: 974 -SLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQL 1032
S+ LQ LAQ EQ L+E Q+ N L E + + + E+ L
Sbjct: 2094 QSVRELQLTLAQKEQEILELRET--QQRNNL------EALPHSHKTSPMEEQSLKLDSLE 2145
Query: 1033 EEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAE--------------CQAAMLRKD 1078
R+L+ + A+ + +A + + EK + LA+ QA++L +D
Sbjct: 2146 PRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERD 2205
Query: 1079 KEGAALREDLERTQKELEK 1097
E L+++LE T++ LEK
Sbjct: 2206 SEQQRLQDELELTRRALEK 2224
Score = 154 bits (388), Expect = 8e-37
Identities = 221/1003 (22%), Positives = 426/1003 (42%), Gaps = 171/1003 (17%)
Query: 234 EMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERE--RGRTAAEDNVRL 291
++RL +++ +V K LRE +++L + R + ++ Q Q E+E +G E RL
Sbjct: 119 QLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHG-RL 177
Query: 292 TCLVAEL----QKQWEVTQATQNTVKELQ-----------TCLQGLELGAAEKEEDYHTA 336
L E+ + E+ AT + EL+ TC L +GA +E +
Sbjct: 178 LSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGR 237
Query: 337 L--RRLESMLQPLAQELEATRDSLDKKNQHLA-SFPGWLAMA--QQKADTASDTKGRQEP 391
+ R +L LA+ E +++ ++ + + G L A Q + S + +
Sbjct: 238 MDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQK 297
Query: 392 IPSDAAQEMQELGEKLQALERERTKV--EEVNRQQSAQLEQLVKELQLKEDARASLERLV 449
D + ++ L E ++ LE T++ E + ++AQ E+L SL++++
Sbjct: 298 QNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKL------------SLQQVI 345
Query: 450 KEMAPLQEE-----LSGKG-----------------QEADQ--------LWRR---LQEL 476
K++ + E G G Q+AD+ L RR +Q+L
Sbjct: 346 KDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDL 405
Query: 477 LAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQK 536
+ +E + L+++ Q +EE + L Q ++ LT + L Q + V L +++
Sbjct: 406 RQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKER 465
Query: 537 KQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQ----EAWGKPEEEQ 592
+ L + ++ L QQ+ +LE+ A L VN LQ A G+ EE+Q
Sbjct: 466 ELLQKAREELRQQLEVLEQEAW--------------RLRRVNVELQLQGDSAQGQKEEQQ 511
Query: 593 RGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQR 652
L A + ++QE E +Q+ + L ++ + LE + + L+Q
Sbjct: 512 EELHLAVRERERLQEMLMGLEAKQS-----ESLSELITLREALESS----HLEGELLRQE 562
Query: 653 ESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQL 712
++ + +LA E A + + ++ + +R A + A EA+ K G QQL
Sbjct: 563 QTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSAL---NEALALDKVGLNQQL 619
Query: 713 REEVEQCQQLA---EARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAA 769
+ E+ Q + EA + AL+ +++ AEK ++ + + L A
Sbjct: 620 LQLEEENQSVCSRMEAAEQARNALQ---------VDLAEAEKRREALW----EKNTHLEA 666
Query: 770 QLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLS----MAEAVLREHKT 825
QL Q+ + +LQA +R ++++++Q +LS EA + +
Sbjct: 667 QL--------------QKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQ 712
Query: 826 LVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEA--QQREEELRALQEELSQAKCS 883
L Q+ K Q E L RA E+E ++E+ A E Q E + + L E+L +
Sbjct: 713 LHQEAKRQEEVLARA-------VQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSA 765
Query: 884 SEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASRE 943
E + E Q+Q +L +Q+ +T KE ++ + C EL + A +E
Sbjct: 766 KELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQE 825
Query: 944 REGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTL 1003
R+ RQ+A +QE ++ E+ KAA + ++ Q ++ + + QEL
Sbjct: 826 RDAAARQLAQAEQEGKTALEQQKAAH---------EKEVNQLREKWEKERSWHQQELAKA 876
Query: 1004 KFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAA------------EEAVEKLKA 1051
L E M+ + RLK E ++++ Q EE+ Q ++A +E L
Sbjct: 877 LESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQ 936
Query: 1052 TQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTK-------IQE 1104
TQ ++ + + + L++ + L+ L+ Q+EL++A + +QE
Sbjct: 937 TQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQE 996
Query: 1105 YYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRD 1147
+ L Q+ + ++ + + + L + +++ +E+ + E LR+
Sbjct: 997 ESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRE 1039
Score = 152 bits (384), Expect = 2e-36
Identities = 245/1054 (23%), Positives = 433/1054 (41%), Gaps = 176/1054 (16%)
Query: 235 MRLELDQLEVREKQLRE----RMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVR 290
+ L L + E R L+E R Q+L Q+++ A QGEQ + + E +
Sbjct: 1057 LTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEA---QGEQKELSAQMELLRQEVKEK 1113
Query: 291 LTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQE 350
+A+ + E +A+ T ++L+ L E AA+ + LR ES L+ LA E
Sbjct: 1114 EADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ----LRLRSTESQLEALAAE 1169
Query: 351 LEATRDSLDKKNQHLASFPGWLAMAQQKA-DTASDTKGRQEPIPS--------DAAQEMQ 401
+ + + LAS L A ++ + G + PS + A+ +
Sbjct: 1170 QQPGNQA--QAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLF 1227
Query: 402 ELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSG 461
+ G L AL E ++ L +L ++L + R L V++ L+E L+
Sbjct: 1228 KRGPLLTALSAEAV---------ASALHKLHQDLWKTQQTRDVLRDQVQK---LEERLTD 1275
Query: 462 KGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLE--QEVRSLTRQLQFLE 519
E Q+ LQ+L S +EE ++ E KQ E EL+E + + SL +L+ E
Sbjct: 1276 TEAEKSQVHTELQDLQRQLSQNQEEKSKW--EGKQNSLESELMELHETMASLQSRLRRAE 1333
Query: 520 TQLAQVSQHVSDLEEQKKQLIQDKDHLSQQV----------GMLERLAGPPGPELPVAGE 569
Q + L+ K+ L +HL V G+LE L + E
Sbjct: 1334 LQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393
Query: 570 KNEALVPVNSSLQEAWGKPEEEQRGLQE--AQLDDTKVQEGSQEEELRQANRELEKELQ- 626
+ E+ +LQE + + LQE A L T + + E LR +ELEK+ +
Sbjct: 1394 EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREM 1453
Query: 627 ----------NVVGRNQ---LLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHL 673
++ RNQ L + ++Q L+ L+ A+Q L ++ IR L
Sbjct: 1454 QKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIREL 1513
Query: 674 GDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLA---EARHREL 730
E R E ++ +K+ +++S+ G+ Q L++++ + LA E H ++
Sbjct: 1514 EKDRETQ----RNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKM 1569
Query: 731 RALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQA 790
+CQQ +LI+ L ++ Q V L LE E+Q +
Sbjct: 1570 -----ECQQ--KLIKELEGQRETQRVA-------------LTHLTLDLEERSQELQAQSS 1609
Query: 791 QVVDLQAK---MRAALDDQD-KVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELL 846
Q+ DL++ + L ++D +V+SQ E + R+ + L Q L+ ++ QEL+
Sbjct: 1610 QIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRD--------QELM 1661
Query: 847 QCSEREGALQEERADEAQQREEELRALQ---EELSQAKCSSEEAQLEHAELQEQLHRANT 903
ER L+++R + + EE+L ++ E + + + E AE + +A
Sbjct: 1662 LQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQR 1721
Query: 904 DTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGL--------------ER 949
+ E + + +KE+ E + ELQ+ K+ ++ +GL E+
Sbjct: 1722 GSLE---HMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQ 1778
Query: 950 QVAGLQQE-----------KESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQ 998
++ LQQ+ ++SLQ +L A+ A L Q +Q+AQ +E +
Sbjct: 1779 EIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKE 1838
Query: 999 ELNTLKFQLSAEIMDYQSR---LKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQAD 1055
+ + L+ L M + R L++ E+ + L +L +GR++QA EE + L+A +
Sbjct: 1839 KADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESRE 1898
Query: 1056 MGEKLSCTSNHLAE------------------CQAAMLRKDKEGAALRED---------- 1087
+ L AE QA + +D+E ALR +
Sbjct: 1899 QEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEA 1958
Query: 1088 ----LERTQKELEKATTKIQEYYNKLCQEV---TNRERNDQKMLADLDDLNRTKKYLEER 1140
E Q+ L KA +Q L ++ + E + + A LD + LEE
Sbjct: 1959 ARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEA 2018
Query: 1141 L---IELLRDKDALWQKSDALEFQQKLSAEERWL 1171
L ++D+D +Q+ D + QQ L+ + L
Sbjct: 2019 LRIQEGEIQDQDLRYQE-DVQQLQQALAQRDEEL 2051
Score = 151 bits (381), Expect = 5e-36
Identities = 247/1024 (24%), Positives = 423/1024 (41%), Gaps = 174/1024 (16%)
Query: 230 EGFDEMRLELDQLEVREKQLRERMQQLDRENQELRA-AVSQQGE--QLQTERERGRTAAE 286
E + ++ + DQ E K LR+R+Q+L E L V QGE L ERE + A E
Sbjct: 414 EAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKARE 473
Query: 287 DNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALR---RLESM 343
+ +R V E Q+ W + + ELQ + E++E+ H A+R RL+ M
Sbjct: 474 E-LRQQLEVLE-QEAWRLRRVNV----ELQLQGDSAQGQKEEQQEELHLAVRERERLQEM 527
Query: 344 LQPLAQELEATRDSLDKKNQHLAS--FPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQ 401
L L + + L + L S G L +Q TA+ R E ++ +
Sbjct: 528 LMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAA--LARAEQSIAELSSSEN 585
Query: 402 ELGEKLQALERERTKVEEVNRQQSAQLEQLVKEL-QLKEDARASLERL-VKEMA--PLQE 457
L ++ L K+ +N + L ++L QL+E+ ++ R+ E A LQ
Sbjct: 586 TLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQV 645
Query: 458 ELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQF 517
+L+ + + LW + L A EE AEL+ + + QEEKE +++++ Q +
Sbjct: 646 DLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEA 705
Query: 518 LETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPV 577
TQL Q+ Q EE + +Q+K EALV
Sbjct: 706 ATTQLEQLHQEAKRQEEVLARAVQEK----------------------------EALVRE 737
Query: 578 NSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEG 637
++L+ E +++ L E Q + L A LE L +N ++E
Sbjct: 738 KAALEVRLQAVERDRQDLAE------------QLQGLSSAKELLESSLFEAQQQNSVIEV 785
Query: 638 KLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQ-MEASLLAVRKAKEAMKAQMA 696
L+ Q + Q + IQG + L+ E + R +Q +A+ + +A++ K +
Sbjct: 786 TKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE 845
Query: 697 EKEAILQSKEGECQQLREEVEQ-----CQQLA---EARHRELRALESQCQQQTQLIEVLT 748
+++A + E E QLRE+ E+ Q+LA E+ RE LE + ++Q +E +
Sbjct: 846 QQKA---AHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902
Query: 749 AEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDK 808
A++ E A+ AL Q QLE + V L+ ++ Q ++ A ++
Sbjct: 903 AQR-----------EEERTQAESALCQMQLETEKERVSLLET-LLQTQKELADASQQLER 950
Query: 809 VQSQLSMAEAVLREHKT---LVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQ 865
++ + + + L+E +T L QL+E L A Q + ALQEE + Q
Sbjct: 951 LRQDMKVQK--LKEQETTGILQTQLQEAQRELKEAARQH----RDDLAALQEESSSLLQD 1004
Query: 866 REEELRALQEELSQAKCSSEEAQLEHAELQEQLHRA---NTDTAELGIQVCALT---VEK 919
+ + + +++ SQ + +L E+QE+L N EL + +LT +EK
Sbjct: 1005 KMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEK 1064
Query: 920 ER----VEEALACAVQEL----QDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAA 971
E+ ++EA + QEL QD +EA ++E L + E L++++K +A
Sbjct: 1065 EQRLLVLQEADSIRQQELSALRQDMQEAQGEQKE--------LSAQMELLRQEVKEKEAD 1116
Query: 972 AGSLPGLQAQLAQAEQRAQSLQEAAH---QELNTLKFQLSAEIMDYQSRLKNAGEECKSL 1028
LAQ Q + L EA+H Q+L + A+ Q RL++ + ++L
Sbjct: 1117 F---------LAQEAQLLEEL-EASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEAL 1166
Query: 1029 RGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAM----LRKDKEGA-- 1082
+ ++ G Q QA + A Q +G +A L D+ GA
Sbjct: 1167 AAE-QQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARS 1225
Query: 1083 ---------------------ALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQ 1121
L +DL +TQ+ + ++Q KL + +T+ E
Sbjct: 1226 LFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQ----KLEERLTDTEAEKS 1281
Query: 1122 KMLADLDDLNR--------------TKKYLEERLIELLRDKDALWQKSDALEFQQKLSAE 1167
++ +L DL R + LE L+EL +L + E Q+ +
Sbjct: 1282 QVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQG 1341
Query: 1168 ERWL 1171
ER L
Sbjct: 1342 EREL 1345
Score = 143 bits (360), Expect = 1e-33
Identities = 196/874 (22%), Positives = 378/874 (43%), Gaps = 129/874 (14%)
Query: 224 LNNEALEGFDEMRLELDQLEV----REKQL---RERMQQLDRENQELRAAVSQQ------ 270
L E ++ ++ R L+ L + RE++L RE++++L+++ + R + Q
Sbjct: 1474 LQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEK 1533
Query: 271 -GEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEK 329
+ ++++R + + + V L CL EL++ + Q +KEL+ +
Sbjct: 1534 KDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEG-----------Q 1582
Query: 330 EEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKA----DTASDT 385
E AL L L+ +QEL+A + H L Q+ + +
Sbjct: 1583 RETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEEL 1642
Query: 386 KGRQEPIPSDAAQEMQEL---GEKLQALERERTKVEEVNRQQSAQLE--------QLVKE 434
+ ++E + D + QEL E++Q LE +RT+ ++ + Q++ +L +
Sbjct: 1643 QRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQ 1702
Query: 435 LQLKEDA-----------RASLERLV-------KEMAPLQEELSGKGQEADQLWRRLQEL 476
QL ++ R SLE + KE+ QE + + DQL ++LQ L
Sbjct: 1703 RQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGL 1762
Query: 477 LAHT-------SSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHV 529
S E+E+ L+++ ++ +E+ EL EQ ++S QL + LAQ Q +
Sbjct: 1763 HRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQS---QLDEAQRALAQRDQEL 1819
Query: 530 SDLEEQKKQLIQDKDHLSQQV----GMLERL-----------------AGPPGPELPVAG 568
L+++++Q ++ + ++ G LE+ A EL V G
Sbjct: 1820 EALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEG 1879
Query: 569 EKNEALVPVNSSLQEAWGKPEEEQRGLQEA---QLDDTKVQEGSQEEELRQAN---RELE 622
+ +AL V L+ + E+ LQ+ Q + +V+ + ++ QA +E +
Sbjct: 1880 RRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERD 1939
Query: 623 KELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLL 682
+EL+ + +Q + +A +A +ALQ+ +L E L +EAS
Sbjct: 1940 QELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTA 1999
Query: 683 AVRKAKEAMKAQMAEKEAILQSKEGECQ----QLREEVEQCQQLAEARHRELRALESQCQ 738
++ + +A +A + E L+ +EGE Q + +E+V+Q QQ R ELR Q
Sbjct: 2000 TLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELR----HQQ 2055
Query: 739 QQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAK 798
++ QL+E A++ Q+ + N +E + E++ L V +LQ
Sbjct: 2056 EREQLLEKSLAQRVQENMIQEKQNLGQEREEE-------------EIRGLHQSVRELQLT 2102
Query: 799 MRAALDDQDKVQ----SQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGA 854
+ A +Q+ ++ Q + EA+ HKT ++EQ+ L+ + + + A
Sbjct: 2103 L--AQKEQEILELRETQQRNNLEALPHSHKT--SPMEEQSLKLDSLEPRLQRELERLQAA 2158
Query: 855 LQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELG--IQV 912
L++ A E + RE+ + L L+Q K S Q LQ + +++ L +++
Sbjct: 2159 LRQTEAREIEWREKA-QDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELEL 2217
Query: 913 CALTVEKERVEEALACAVQELQDAKEAASR--EREGLERQVAGLQQEKESLQEKLKAAKA 970
+EKER+ A + EL E + E G+E + + EK+S +++L+ +
Sbjct: 2218 TRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQ 2277
Query: 971 AAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLK 1004
A L +++L + + +S E +E LK
Sbjct: 2278 AVARLEIDRSRLQRHNVQLRSTLEQVERERRKLK 2311
Score = 140 bits (352), Expect = 1e-32
Identities = 216/1019 (21%), Positives = 427/1019 (41%), Gaps = 135/1019 (13%)
Query: 227 EALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAE 286
+ALE + ++EL E+R K+ + M+ + + +E R Q+Q E E+
Sbjct: 875 KALESLEREKMEL---EMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEK------ 925
Query: 287 DNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQP 346
R++ L LQ Q E+ A+Q +L+ Q +++ +++E +L+ +
Sbjct: 926 --ERVSLLETLLQTQKELADASQ----QLERLRQDMKVQKLKEQETTGILQTQLQEAQRE 979
Query: 347 LAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKG-RQEPIPSDAAQEM--QEL 403
L + RD L + +S + Q K D + + + + D +Q + QE+
Sbjct: 980 LKEAARQHRDDLAALQEESSS------LLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEV 1033
Query: 404 GEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKE--MAPLQEELSG 461
EKL+ + +E NR Q KEL+ +E A +L + KE + LQE S
Sbjct: 1034 QEKLR-------ETQEYNRIQ--------KELE-REKASLTLSLMEKEQRLLVLQEADSI 1077
Query: 462 KGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQ-----EEKELLEQ-EVRSLTRQ- 514
+ QE L + +QE ++ LR+E K+++ +E +LLE+ E +T Q
Sbjct: 1078 RQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQ 1137
Query: 515 ----LQFLETQLAQVSQHVSDLEEQKKQLI--QDKDHLSQQVGMLERLAGPPGPELPVAG 568
L E + AQ+ + E Q + L Q + +Q L L L
Sbjct: 1138 LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVC 1197
Query: 569 EKNEALVPVNSSLQEAWGKPEEEQRG----------------------LQEAQLDDTKVQ 606
E L S WG E +Q G L + D K Q
Sbjct: 1198 ESRPELSGGGDSAPSVWGL-EPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQ 1256
Query: 607 EGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAE 666
+ + LR ++LE+ L + + +LQ LQ Q+ +S +G SLE+E
Sbjct: 1257 Q--TRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESE 1314
Query: 667 QASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKE---GECQQLREEVEQCQQLA 723
+ L + M + +R+A+ E+E + +KE + + L+ V + + A
Sbjct: 1315 ---LMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQA 1371
Query: 724 EAR---HRELRALESQCQQQTQLIEVLTAEKGQ--QGVGPPTDNEARELAAQLALSQAQL 778
A +LR S + + + +E E+ Q Q G + + L LAL L
Sbjct: 1372 SAAGILEEDLRTARSALKLKNEEVE-SERERAQALQEQGELKVAQGKALQENLALLTQTL 1430
Query: 779 EVHQGEVQRLQAQVVDLQAK---MRAALD---------------DQDKVQSQLSMAEAVL 820
+ EV+ L+ Q+ +L+ + +AAL+ Q+++Q +L +VL
Sbjct: 1431 AEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ-ELEKCRSVL 1489
Query: 821 REHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREE-------ELRAL 873
EH + Q +EQ + R ++EL + E + + E + E +++++ +++ L
Sbjct: 1490 -EHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDL 1548
Query: 874 QEELSQAKCSSEEAQLEH--AELQEQLHR---ANTDTAELGIQVCALTVEKERVE-EALA 927
+++L +C + E + H E Q++L + +T + + L +E+ E +A +
Sbjct: 1549 KKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQS 1608
Query: 928 CAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQ 987
+ +L+ +RE + +++V + ++E ++E + + L +L ++
Sbjct: 1609 SQIHDLESHSTVLARELQERDQEV---KSQREQIEELQRQKEHLTQDLERRDQELMLQKE 1665
Query: 988 RAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVE 1047
R Q L++ ++ L+ L + + R + + + ++ + EE +A ++E
Sbjct: 1666 RIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLE 1725
Query: 1048 KLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYN 1107
+K D +++ C H+ E Q + +++ L + T L + +I
Sbjct: 1726 HMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQ 1785
Query: 1108 KLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRD-------KDALWQKSDALE 1159
+L + E +Q + + LD+ R ++ L L ++ ++ + +K+DAL+
Sbjct: 1786 QLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQ 1844
Score = 136 bits (342), Expect = 2e-31
Identities = 220/1048 (20%), Positives = 418/1048 (39%), Gaps = 148/1048 (14%)
Query: 210 QTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLE-------------------------- 243
QT ++ D S + +E+R +L+ LE
Sbjct: 450 QTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEE 509
Query: 244 --------VREKQ-LRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCL 294
VRE++ L+E + L+ + E + + E L++ G ++ +T
Sbjct: 510 QQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAA 569
Query: 295 VAELQKQWEVTQATQNTVKELQTCLQ------------------GLELGAAEKEEDYHTA 336
+A ++ +++NT+K L+ GL + EE+ +
Sbjct: 570 LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSV 629
Query: 337 LRRLE------SMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQE 390
R+E + LQ E E R++L +KN HL A Q+ + ++ +
Sbjct: 630 CSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLE------AQLQKAEEAGAELQADLR 683
Query: 391 PIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVK 450
I + + ++L E E T++E+++++ Q E L + +Q K E LV+
Sbjct: 684 DIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEK-------EALVR 736
Query: 451 EMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRS 510
E A L+ L ++ L +LQ L + E L E +++ + K LE ++++
Sbjct: 737 EKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQT 796
Query: 511 LTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEK 570
+T+ + ++ ++ + +L+ ++ Q Q++D ++Q+ E+ + A EK
Sbjct: 797 VTQAKEVIQGEVRCLK---LELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEK 853
Query: 571 NEALVPVNSSLQEAWGKPE-------------EEQRGLQEAQLDDTKVQEGSQEEELRQA 617
+ + +W + E E + L+E Q + +Q +EE +
Sbjct: 854 EVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAE 913
Query: 618 NRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQM 677
+ + +L+ R LLE LQ + A QQ E Q EQ + L Q+
Sbjct: 914 SALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQL 973
Query: 678 EASLL----AVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRAL 733
+ + A R+ ++ + A E ++LQ K L+++VE + A+ R +
Sbjct: 974 QEAQRELKEAARQHRDDLAALQEESSSLLQDK----MDLQKQVEDLKSQLVAQDDSQRLV 1029
Query: 734 ESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVV 793
E + Q E L + + + E L L + +L V Q Q ++
Sbjct: 1030 EQEVQ------EKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELS 1083
Query: 794 DLQAKMRAALDDQDKVQSQLSMAEAVLREHKT-LVQQLKEQNEALNRAHVQE-----LLQ 847
L+ M+ A +Q ++ +Q+ + ++E + + Q + E L +H+ E L
Sbjct: 1084 ALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLW 1143
Query: 848 CSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAE 907
E + A + R + + E L A Q+ +QA+ ++ A L ++ LQ+ L E
Sbjct: 1144 AQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASL-YSALQQALGSVCESRPE 1202
Query: 908 L------GIQVCALTVEKERVE--------------EALACAVQELQDAKEAASREREGL 947
L V L ++ EA+A A+ +L + R+ L
Sbjct: 1203 LSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVL 1262
Query: 948 ERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQL 1007
QV Q+ +E L + L LQ QL+Q Q +S E L + +L
Sbjct: 1263 RDQV---QKLEERLTDTEAEKSQVHTELQDLQRQLSQ-NQEEKSKWEGKQNSLESELMEL 1318
Query: 1008 SAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEE----AVEKLKATQADMGEKLSCT 1063
+ QSRL+ A + +G+ E LQAA+E VE L+A + + S
Sbjct: 1319 HETMASLQSRLRRAELQRMEAQGERE----LLQAAKENLTAQVEHLQAAVVEARAQASAA 1374
Query: 1064 ---SNHLAECQAAMLRKDKEGAALREDLERTQK--ELEKATTK-IQEYYNKLCQEVTNRE 1117
L ++A+ K++E + RE + Q+ EL+ A K +QE L Q + RE
Sbjct: 1375 GILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAERE 1434
Query: 1118 RNDQKMLADLDDLNRTKKYLEERLIELL 1145
+ + + +L + ++ +++ +ELL
Sbjct: 1435 EEVETLRGQIQELEKQRE-MQKAALELL 1461
Score = 111 bits (278), Expect = 5e-24
Identities = 228/987 (23%), Positives = 393/987 (39%), Gaps = 185/987 (18%)
Query: 348 AQELEATRDSLDKKNQ-HLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQ-EMQELGE 405
+QE + + +L +K Q + + W +++ + PIP E L E
Sbjct: 45 SQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGG------PIPQRWENVEEPNLDE 98
Query: 406 KLQALERERTKVE---EVNRQQSAQLEQL-VKELQLKED--------ARASLERLVKEMA 453
L LE E+ + E EVN Q +E+ V L+ED +RA E + KE
Sbjct: 99 LLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQ 158
Query: 454 PLQEE------LSGKGQEADQLWRRL----QELLAHTSSWEEELAELRREK--------- 494
E+ L G+ LWR + + L S+ + +L EL+ E
Sbjct: 159 WQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLT 218
Query: 495 --------KQQQEEKELLEQEVRS------LTRQLQFLETQLAQVSQHVSDLEEQ---KK 537
Q +E + R L + Q LE + + SQ + L+ Q +K
Sbjct: 219 CCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEK 278
Query: 538 QLIQDK-DHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWG----KPEEEQ 592
+QD+ LS + ++ + E E L ++ L E +EE+
Sbjct: 279 AELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEK 338
Query: 593 RGLQEAQLDDTKVQ--------EGSQEE------------------------------EL 614
LQ+ D T+V +GS E
Sbjct: 339 LSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRR 398
Query: 615 RQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLG 674
RQA ++L ++L LL+ + + + +AL+QR + G +L + ++
Sbjct: 399 RQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEV 458
Query: 675 DQMEASLLAVRKAKEAMKAQM--AEKEAIL------------QSKEGECQQLREEVEQCQ 720
D + ++KA+E ++ Q+ E+EA S +G+ ++ +EE+
Sbjct: 459 DSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAV 518
Query: 721 QLAEARHRELRALES-QCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLE 779
+ E L LE+ Q + ++LI + A + G E E+ A LA ++ +
Sbjct: 519 RERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIA 578
Query: 780 VHQGEVQRLQAQVVDLQA---KMRA-----ALDD----------QDKVQSQLSMAEAVLR 821
L+ +V DL+A K+ A ALD +++ QS S EA +
Sbjct: 579 ELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQ 638
Query: 822 EHKTLVQQLKE---QNEAL--NRAHVQELLQCSEREGA-LQEERADEAQQREEELRALQE 875
L L E + EAL H++ LQ +E GA LQ + D +++EE + L E
Sbjct: 639 ARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSE 698
Query: 876 ELSQAKCSSEEAQLEHAELQEQ---LHRANTDTAELGIQVCALTVEKERVE---EALACA 929
Q + ++ + + H E + Q L RA + L + AL V + VE + LA
Sbjct: 699 SRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQ 758
Query: 930 VQELQDAKEAASRE--------------REGLERQVAGLQQEKESLQEKLKAAK------ 969
+Q L AKE + LE Q+ + Q KE +Q +++ K
Sbjct: 759 LQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTE 818
Query: 970 --AAAGSLPGLQAQLAQAEQRAQSL---QEAAHQ-ELNTLKFQLSAEIMDYQSRLKNAGE 1023
A QLAQAEQ ++ Q+AAH+ E+N L+ + E +Q L A E
Sbjct: 819 RSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALE 878
Query: 1024 ECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAA 1083
+ + +LE + ++ Q EA++ + + E C L +KE +
Sbjct: 879 SLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALC---------QMQLETEKERVS 929
Query: 1084 LREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLD-DLNRTKKYLEERLI 1142
L E L +TQKEL A+ +++ +L Q++ ++ +Q+ L L ++ L+E
Sbjct: 930 LLETLLQTQKELADASQQLE----RLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAAR 985
Query: 1143 ELLRDKDALWQKSDALEFQQKLSAEER 1169
+ D AL ++S +L Q K+ +++
Sbjct: 986 QHRDDLAALQEESSSL-LQDKMDLQKQ 1011
Score = 50.8 bits (120), Expect = 9e-06
Identities = 104/504 (20%), Positives = 198/504 (39%), Gaps = 97/504 (19%)
Query: 209 LQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQ-LEVREKQLRERMQQLDRENQELRAAV 267
L+ E+ + + ++ +L+ +L++ L ++E +++++ + + Q+L+ A+
Sbjct: 1985 LEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQAL 2044
Query: 268 SQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAA 327
+Q+ E+L+ ++ER + + + +KQ + + ++ L ++ L+L A
Sbjct: 2045 AQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLA 2104
Query: 328 EKEEDY----HTALR--------------------RLESMLQPLAQELEATRDSLDKKNQ 363
+KE++ T R +L+S+ L +ELE + +L Q
Sbjct: 2105 QKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAAL---RQ 2161
Query: 364 HLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQ 423
A W AQ A + + TK + +QE+ LQA ER
Sbjct: 2162 TEAREIEWREKAQDLALSLAQTKA--------SVSSLQEVAMFLQASVLER--------- 2204
Query: 424 QSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSW 483
++ ++L EL+L A ERL A EL +G++ QL S
Sbjct: 2205 -DSEQQRLQDELELTRRALEK-ERLHSPGATSTAELGSRGEQGVQL--------GEVSGV 2254
Query: 484 EEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDK 543
E E + EK+ ++ E L+Q V L L+ Q+ + +E ++++L ++
Sbjct: 2255 EAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREA 2314
Query: 544 DHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDT 603
+ Q G LE + +A +Q G + D
Sbjct: 2315 MR-AAQAGSLE--------------------------ISKATASSPTQQDGRGQKNSDAK 2347
Query: 604 KVQEGSQEEELRQANRELE-KELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLAS 662
V E +E L QA LE K+ Q+ + R+ +L L S LA
Sbjct: 2348 CVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGL---------HHSLSHSLLAV 2398
Query: 663 LEAEQASI-----RHLGDQMEASL 681
+A +A++ R L + + SL
Sbjct: 2399 AQAPEATVLEAETRRLDESLTQSL 2422
Score = 42.4 bits (98), Expect = 0.003
Identities = 94/472 (19%), Positives = 185/472 (39%), Gaps = 84/472 (17%)
Query: 780 VHQGEVQRLQAQVVDLQA----KMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNE 835
V + +V LQ Q+ + QA K++ + + Q + + + +A + ++++ Q+L+++ E
Sbjct: 19 VLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLE 78
Query: 836 ALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQ 895
A Q E R +E QQR E +L E +Q + E+A + + L+
Sbjct: 79 ATGGPIPQRWENVEEPNLDELLVRLEEEQQRCE---SLAEVNTQLRLHMEKADVVNKALR 135
Query: 896 EQLHRANTDTA----ELGIQVCALTVEKERVEEALACAVQELQDA-KEAASREREGLERQ 950
E + + D + EL + +E+E + L L +E + R LE +
Sbjct: 136 EDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMK 195
Query: 951 VAGLQQEKESLQEKLKAAKA------------------AAGSLPGLQ-AQLAQAEQRAQS 991
A + E E ++ + + +G + G + AQL + Q
Sbjct: 196 SATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQE 255
Query: 992 LQEAAH---QELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEK 1048
L++ AH QEL LK Q E + Q R+ + Q E+ + ++A E VE
Sbjct: 256 LEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEI 315
Query: 1049 LKATQADMGEKLSCTSNHLAECQAAMLRKDKE--------------GAALREDLERTQ-- 1092
L+ ++ E + S + E + ++ + K+ G+ LE
Sbjct: 316 LETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSI 375
Query: 1093 ------KELEKATTKIQEYYNKL-------------CQEVTN--RERNDQ---------- 1121
++ +KA T ++ + CQE N ++++DQ
Sbjct: 376 FSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQ 435
Query: 1122 ---KMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEERW 1170
K+ + D L L+ + L ++++ L + + L Q ++ +E W
Sbjct: 436 RLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAW 487
Score = 40.4 bits (93), Expect = 0.013
Identities = 72/335 (21%), Positives = 136/335 (40%), Gaps = 44/335 (13%)
Query: 817 EAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADE-------AQQREEE 869
+ VL E +QQ +N+A + ++ + +R+ L + + Q+ E+
Sbjct: 17 QLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKR 76
Query: 870 LRALQEELSQAKCSSEEAQLEH--AELQEQLHRANTDTAELGIQVCALTVEKERVEEALA 927
L A + Q + EE L+ L+E+ R + AE+ Q L + E+ +
Sbjct: 77 LEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCES-LAEVNTQ---LRLHMEKADVVNK 132
Query: 928 CAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQ 987
++++ SR R+ L R+ + Q E+E + LK G L L ++ +
Sbjct: 133 ALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEH---GRLLSLWREVVTFRR 189
Query: 988 RAQSLQEAAHQELNTLK---FQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQ------ 1038
++ A ++L LK +LS ++ RL G + + G GR+
Sbjct: 190 HFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRL-TVGAQSREPNGSGRMDGREPAQLLL 248
Query: 1039 LQAAEEAVEK-----------LKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALRED 1087
L A + +EK LK +Q D+ EK + + E A + + K+ ED
Sbjct: 249 LLAKTQELEKEAHERSQELIQLK-SQGDL-EKAE-LQDRVTELSALLTQSQKQ----NED 301
Query: 1088 LERTQKELEKATTKIQEYYNKLCQEVTNRERNDQK 1122
E+ K L + ++ + +L + + RN Q+
Sbjct: 302 YEKMIKALRETVEILETNHTELMEHEASLSRNAQE 336
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 153 bits (387), Expect = 1e-36
Identities = 232/1006 (23%), Positives = 416/1006 (41%), Gaps = 159/1006 (15%)
Query: 291 LTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALR---RLESMLQPL 347
L AE Q Q + + ++ LE AAE +E+ L+ RLE L+ L
Sbjct: 365 LQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEAL 424
Query: 348 AQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKL 407
+ LEA++ +L +K + A Q + + + ++ RQ+ + S E+ L +
Sbjct: 425 S--LEASQ-ALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSS----EVDTLKQSC 477
Query: 408 QALERERTKVEEVNRQQSAQLEQLVKELQLKEDA------------RASLER------LV 449
LER T ++ + ++A L +LQ+ E+ R+ L + L
Sbjct: 478 WDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLR 537
Query: 450 KEMAPLQEELSGKGQEADQLWRRLQELLAHTSS-------WEEELAELRREKKQQQEEKE 502
++M LQ +L E L +L+ A SS ++++LA + + + Q E
Sbjct: 538 QQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMA 597
Query: 503 LLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLER-LAGPPG 561
++ + L+ L+ + +SQ +++ + + +++K ++ Q+ +E +
Sbjct: 598 HIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRS---MKEKGRIAAQLQGIEADMLDQEA 654
Query: 562 PELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEA-----QLDDTKV---QEGSQEEE 613
+ + K + L+E G+ E QR A QL+ K+ Q Q E
Sbjct: 655 AFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEA 714
Query: 614 LRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHL 673
L+Q + +L K+L Q E L ALQ Y LQ R +QG AS E +++
Sbjct: 715 LQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNE 774
Query: 674 GDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREE-------VEQCQQLAEAR 726
+EA+L A + KE + E + ++LREE VE QQ A
Sbjct: 775 KIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAAL 834
Query: 727 HRELRALESQCQQQTQLIEVL---TAEKGQ-----QGVGPPTDNEARELAAQLALSQAQL 778
++++ ++ Q QQ ++E K Q + D+E +EL +L +
Sbjct: 835 KKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEK 894
Query: 779 EVHQGEVQRLQAQV-------VDLQAKMRAALDDQDKVQSQLSMAE-------AVLREHK 824
+ E+ RL +V DL+ +++A ++D++++ L + AV ++
Sbjct: 895 RTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANE 954
Query: 825 TLVQQLKEQNEALNRAHVQELLQCSEREG----ALQEERADEAQQREEELRALQEELSQA 880
L +Q++E + +A + E Q R G + Q+E + + E + L L +A
Sbjct: 955 ALKKQIEELQQEARKA-ITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEA 1013
Query: 881 KCSSEEAQLEHAELQEQ---------LH-RANTDTAELGIQVCALTVEKERVEEALACAV 930
+ E A E +L+ Q LH R AEL + T+ ++ ++E +A
Sbjct: 1014 LAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTS 1073
Query: 931 QELQDAKEAA------SREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGL------ 978
QEL++++E +E G +++ L++ + L +L+ K G L GL
Sbjct: 1074 QELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEK---GKLTGLGQSNAA 1130
Query: 979 ---------------QAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGE 1023
+A L Q + Q++ + +E +K + A Q+ L+ E
Sbjct: 1131 LREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQA----LQASLEKEKE 1186
Query: 1024 ECKSLRGQ---------------------LEEQGRQLQAAEEAVEKLKATQADMGEKLSC 1062
+ SL+ Q L E ++LQA E V+KL+A D+ +
Sbjct: 1187 KVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGK 1246
Query: 1063 TSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTK----IQEYYNKLCQEVTNRER 1118
S +A+ QA E A R L+ QK+L++ +K QE N L EV +ER
Sbjct: 1247 HSQEIAQFQA-------ELAEARAQLQLLQKQLDEQLSKQPVGNQEMEN-LKWEVDQKER 1298
Query: 1119 NDQKMLADLDDLNRTKKYLEERLIELLRD-KDALWQKSDALEFQQK 1163
Q + LD + + E L +LL++ K L + L QK
Sbjct: 1299 EIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQK 1344
Score = 145 bits (365), Expect = 4e-34
Identities = 224/987 (22%), Positives = 408/987 (41%), Gaps = 123/987 (12%)
Query: 224 LNNEALEGFDEMRLELDQ---LEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERER 280
L + A E +EM L + LE + + L Q +E EL+A ++ +LQ + E
Sbjct: 396 LESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVEC 455
Query: 281 GRTAAEDNVRLTCLVAELQKQ-WEVTQAT---QNTVKELQTCLQGLELGAAEKEEDYHTA 336
++ + L+ V L++ W++ +A QN ++ L EE Y
Sbjct: 456 SHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRL 515
Query: 337 LRRLESM----------LQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTK 386
+ ++E M + L Q++ A + L + + L +Q + + +
Sbjct: 516 MAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVR 575
Query: 387 G---RQEPIPSDAAQEMQ------ELGEKLQALERERTKVEEVNRQQSAQLEQ------- 430
+Q + +A +Q ++G+ QA E K+E V+ Q Q
Sbjct: 576 QWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEK 635
Query: 431 --LVKELQLKE----DARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWE 484
+ +LQ E D A+ ++ + ++E+L + +E + RLQ + +S E
Sbjct: 636 GRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLE 695
Query: 485 EELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKD 544
++L +++ Q+ ++ E L+QE L +QL + L Q + L+ D
Sbjct: 696 QQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHY-------D 748
Query: 545 HLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRG---LQEAQLD 601
L ++G L+ A E + +NE ++ + ++LQ A EE RG L+E +
Sbjct: 749 ELQARLGELQGEAA--SREDTICLLQNEKII-LEAALQAAKSGKEELDRGARRLEEGTEE 805
Query: 602 DTKVQE---------GSQEEELRQANRELEKELQNVVGRNQLLEGKL--QALQADYQALQ 650
++ E Q E L+Q L+K++Q + + Q L+ K+ +A + D +
Sbjct: 806 TSETLEKLREELAIKSGQVEHLQQETAALKKQMQKI--KEQFLQQKVMVEAYRRDATSKD 863
Query: 651 QRESAIQGSLASLEAEQASIRHLGDQM-------EASLLAVRKAKEAMKAQMAEKEAILQ 703
Q S ++ + L++E +R Q+ EA L + + ++ MA+ E LQ
Sbjct: 864 QLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQ 923
Query: 704 SKEGECQQLREEVEQCQ------------------QLAEARHRELRALESQCQQQTQLIE 745
S + E ++ ++ Q Q+ E + +A+ Q Q+ +L
Sbjct: 924 SAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGS 983
Query: 746 VLT-AEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALD 804
LT A+K + +N L+ +L + A E E+ +L+AQ ++L
Sbjct: 984 DLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQ----GGSSDSSLA 1039
Query: 805 DQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQ-CSEREGALQEERA--D 861
+++Q+ + +AV KTL+++ ++ AL ++E + E E LQE R
Sbjct: 1040 LHERIQALEAELQAVSHS-KTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRK 1098
Query: 862 EAQQREEELRALQEELSQAKCS------SEEAQLEHAELQEQ-LHRANTDTAELGIQVCA 914
+ ++ EE + L EL K S A EH + E L + D +L +QV A
Sbjct: 1099 KIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQA 1158
Query: 915 LTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGS 974
+ KE + + VQ LQ + E + L+ QVA + E + KAA
Sbjct: 1159 VLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASL---E 1215
Query: 975 LPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEE 1034
L ++ +L E Q LQ A +L + + S EI +Q+ L A + + L+ QL+E
Sbjct: 1216 LSEVKKELQAKEHLVQKLQAEA-DDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDE 1274
Query: 1035 QGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAA----------- 1083
Q + + +E LK + D E+ + + RK+ EG
Sbjct: 1275 QLSKQPVGNQEMENLK-WEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELE 1333
Query: 1084 -LREDLERTQKELEKATTKIQEYYNKL 1109
+EDL TQK+ K+ E N +
Sbjct: 1334 MAQEDLSMTQKDKFMLQAKVSELKNNM 1360
Score = 73.6 bits (179), Expect = 1e-12
Identities = 104/524 (19%), Positives = 222/524 (42%), Gaps = 44/524 (8%)
Query: 234 EMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQT-ERERGRTAAEDNVRLT 292
E+R EL Q+ ++ + +L RE ++R ++ LQ+ ++ER E L
Sbjct: 882 ELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERD----EMETHLQ 937
Query: 293 CLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELE 352
L + ++ VT+A + K+++ E +++ A+ + ++ L +L
Sbjct: 938 SLQFDKEQMVAVTEANEALKKQIE-----------ELQQEARKAITEQKQKMRRLGSDLT 986
Query: 353 ATRDSLDKKNQHLASFPGWLAMAQQKA---DTASDTKGRQEPIPSDAAQEMQELGEKLQA 409
+ + + K++ + G L+ Q+A A+D + Q ++ L E++QA
Sbjct: 987 SAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQA 1046
Query: 410 LERERTKVEEVNRQQSAQLEQLVK-ELQLKEDARASLERLVKEMAPLQEELSGKGQEADQ 468
LE E V +L++++ Q E++R + L E+ +E G ++ +
Sbjct: 1047 LEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDEL----QESRGFRKKIKR 1102
Query: 469 LWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQH 528
L ++L + +L L + +E +LE + L L Q+ V Q
Sbjct: 1103 LEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQR 1162
Query: 529 VSDLEEQKKQLIQD-KDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGK 587
+ + Q K L+Q + L ++ + L AG + L E +
Sbjct: 1163 KEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKE 1222
Query: 588 PEEEQRGLQ--EAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQAD 645
+ ++ +Q +A+ DD +++EG +E+ Q + EL + QLL+ +L Q
Sbjct: 1223 LQAKEHLVQKLQAEADDLQIREGKHSQEIAQ----FQAELAEARAQLQLLQKQLDE-QLS 1277
Query: 646 YQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSK 705
Q + +E ++ ++ ++ I+ L Q++ + RK E + + +LQ+
Sbjct: 1278 KQPVGNQE--MENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGL-------QQLLQNV 1328
Query: 706 EGECQQLREEVEQCQQ---LAEARHRELRALESQCQQQTQLIEV 746
+ E + +E++ Q+ + +A+ EL+ QQ Q +++
Sbjct: 1329 KSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKL 1372
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 152 bits (384), Expect = 2e-36
Identities = 230/1098 (20%), Positives = 445/1098 (40%), Gaps = 232/1098 (21%)
Query: 230 EGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNV 289
E F +++ EL + E + K+L E+M L +E +L+ V + E L ER + +
Sbjct: 860 EEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKI 919
Query: 290 RLTCLVAELQKQWE-----------VTQATQNTVKELQTCLQGLELGAAEKEEDYHTALR 338
+L + E+ ++ E + ++ EL+ + LEL A+ E++ H
Sbjct: 920 QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 979
Query: 339 RLESMLQPLA------------------------QELEATRDSLD-------KKNQHLAS 367
+++++ + +A +L+A D ++ K Q +
Sbjct: 980 KVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD 1039
Query: 368 FPGWLA--------MAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEE 419
G L + + K D K QE I D E Q+L EKL+ E E + ++
Sbjct: 1040 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESI-MDIENEKQQLDEKLKKKEFEISNLQS 1098
Query: 420 VNRQQSA---QLEQLVKELQLK-EDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQE 475
+ A QL++ +KELQ + E+ +E A +++ S +E +++ RL+E
Sbjct: 1099 KIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158
Query: 476 LLAHTSSW-------EEELAELRRE---------------KKQQQEEKELLEQEVRSLTR 513
TS+ E E ++RR+ +K+ + L +++ +L R
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218
Query: 514 QLQFLETQLAQVSQHVSDL-------------------------------EEQKKQLIQD 542
Q LE + +++ + DL EE++++LI D
Sbjct: 1219 VKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND 1278
Query: 543 KDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQR--------- 593
L+ Q G L+ +G +L ++ EALV S ++A+ + EE +
Sbjct: 1279 ---LTAQRGRLQTESGEFSRQL----DEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKA 1331
Query: 594 ------GLQEAQLDDTKVQEGSQEEE---------LRQANREL----EKELQNVVGRNQL 634
LQ ++ D ++E +EE+ L +AN E+ K + + R +
Sbjct: 1332 KNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEE 1391
Query: 635 LEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQ 694
LE + L QA ++ A+ ASLE + +++ + + + A A+ +
Sbjct: 1392 LEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKK 1451
Query: 695 MAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKG-- 752
+ IL + +C++ E+E Q+ A + EL +++ ++ +E L E
Sbjct: 1452 QRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNL 1511
Query: 753 QQGVGPPT--------------------DNEARELAAQLALSQAQLEVHQGEVQRLQAQV 792
QQ + T + E EL A L ++A LE +G++ R+Q ++
Sbjct: 1512 QQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLEL 1571
Query: 793 VDLQAKMRAALDDQDK------------VQSQLSMAEAVLREHKTLVQQLKEQNEALN-- 838
+++++ + ++D+ V+S S +A +R ++ K+ LN
Sbjct: 1572 NQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1631
Query: 839 ----------------------------RAHVQELLQCSE---REGALQEERADEAQQRE 867
+ H+ + L+ E + A+ E RA+ Q
Sbjct: 1632 EIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEI 1691
Query: 868 EELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALA 927
EELRA E+ +++ +E+ L+ +E + LH NT + L + +++ +
Sbjct: 1692 EELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK---LETDISQMQGEME 1748
Query: 928 CAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQ 987
+QE ++A+E A + L++E+++ + K ++ LQ +L +AEQ
Sbjct: 1749 DILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQ 1808
Query: 988 RAQSLQEAAHQELNTLKFQLSAEIMDYQSR-------LKNAGEECKSLRGQLEEQGRQLQ 1040
A + Q+L +L E+ Q R L+ K L Q EE + +
Sbjct: 1809 LALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNIL 1868
Query: 1041 AAEEAVEKLKA------TQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKE 1094
++ V+KL+A QA+ E+ S T +LA+ + L+ + E A R D+ +Q
Sbjct: 1869 RLQDLVDKLQAKVKSYKRQAEEAEEQSNT--NLAKFR--KLQHELEEAEERADIAESQ-- 1922
Query: 1095 LEKATTKIQEYYNKLCQE 1112
+ K K +E + K+ E
Sbjct: 1923 VNKLRVKSREVHTKVISE 1940
Score = 137 bits (345), Expect = 8e-32
Identities = 178/827 (21%), Positives = 346/827 (41%), Gaps = 101/827 (12%)
Query: 394 SDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKE---LQLK--------EDAR 442
++ +EM + E+ Q ++ E K E ++ ++ L+KE LQL+ DA
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 443 ASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRRE-------KK 495
++L+K L+ ++ + A+ EL A E+E +EL+++
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968
Query: 496 QQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLER 555
+ ++EK E +V++LT ++ L+ +A++++ L+E +Q + D +V L +
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1028
Query: 556 LAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLD----DTKVQEGSQE 611
++ E + L+ A K E + + QE+ +D ++ E ++
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKK 1088
Query: 612 EELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIR 671
+E +N + + E + +G L+ K++ LQA + L++ A + S A E +++ +
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQ--LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146
Query: 672 H---------------------LGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGEC- 709
+ + EA +R+ E Q A L+ K +
Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206
Query: 710 QQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAA 769
+L E+++ Q++ + +E ++ + +E ++ KG + R L
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGN------LEKMCRTLED 1260
Query: 770 QLALSQAQLEVHQGEVQRLQAQVVDLQAK---MRAALDDQDKVQSQLSMA-EAVLREHKT 825
QL+ +++ E Q + L AQ LQ + LD+++ + SQLS +A ++ +
Sbjct: 1261 QLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE 1320
Query: 826 LVQQLKEQNEALNR-AHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSS 884
L +QL+E+ +A N AH ALQ R D RE+
Sbjct: 1321 LKRQLEEEIKAKNALAH------------ALQSSRHDCDLLREQY--------------- 1353
Query: 885 EEAQLEHAELQEQLHRANTDTAELGIQVCALTVEK-ERVEEALACAVQELQDAKE---AA 940
EE Q AELQ L +ANT+ A+ + +++ E +EEA Q LQ A+E A
Sbjct: 1354 EEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAV 1413
Query: 941 SREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQEL 1000
+ + LE+ LQ E E L ++ AA +L Q + + E H EL
Sbjct: 1414 NAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAEL 1473
Query: 1001 NTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKL 1060
Q ++ G E ++ EE QL+ + + L+ +D+ E++
Sbjct: 1474 EAS-----------QKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQI 1522
Query: 1061 SCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERND 1120
+ + E + + ++E L+ LE + LE KI +L Q + +R
Sbjct: 1523 AEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI 1582
Query: 1121 QKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAE 1167
+ ++D L R + E + L + + ++DA+ ++K+ +
Sbjct: 1583 AEKDEEIDQLKRNHIRIVESMQSTLDAE--IRSRNDAIRLKKKMEGD 1627
Score = 97.1 bits (240), Expect = 1e-19
Identities = 139/659 (21%), Positives = 269/659 (40%), Gaps = 106/659 (16%)
Query: 605 VQEGSQEEELRQANRELEK---ELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLA 661
++ E+E+ E +K EL + + LE K+ L + LQ + A LA
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905
Query: 662 SLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQ 721
E + Q+EA + V + E + AE A + E EC +L+++++ +
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 722 LAEARHRELRALESQCQQQT-------QLIEVLTAEKG--QQGVGPPTDNEARELAAQLA 772
+E A E++ + T + I LT EK Q+ D+ E
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 773 LSQAQLEVHQ---------------------------GEVQRLQAQVVDLQAKMRAALDD 805
L++A++++ Q G+++ Q ++D++ + + +
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 806 QDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGA----LQEERAD 861
K + ++S ++ + + + L QL+++ + L +A ++EL + E E A +++R+D
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKEL-QARIEELEEEIEAERASRAKAEKQRSD 1144
Query: 862 EAQQREEELRALQE-----------------ELSQAKCSSEEAQLEHAELQEQLHRANTD 904
+++ EE L+E E + + EEA L+H L + + D
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Query: 905 T-AELGIQVCALTVEKERVE----------EALACAVQELQDAKEAASREREGLERQVAG 953
+ AELG Q+ L K+++E + LA V+ + AK + LE Q++
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSE 1264
Query: 954 LQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSL-------QEAAHQELNTLKFQ 1006
L+ ++E Q + A G L + ++ ++L ++A Q++ LK Q
Sbjct: 1265 LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ 1324
Query: 1007 LSAEIMDYQS---RLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSC- 1062
L EI + L+++ +C LR Q EE+ + A+ K A K
Sbjct: 1325 LEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETD 1384
Query: 1063 ---TSNHLAECQAAMLRK-----------DKEGAALREDLERTQKELEKATTKIQEYYNK 1108
+ L E + + ++ + + A+L + +R Q E+E + E N
Sbjct: 1385 AIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDV-ERTNA 1443
Query: 1109 LCQEVTNRERNDQKMLADLD--------DLNRTKKYLEERLIELLRDKDALWQKSDALE 1159
C + ++RN K+LA+ +L ++K EL + K+A + D LE
Sbjct: 1444 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLE 1502
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 152 bits (384), Expect = 2e-36
Identities = 230/1098 (20%), Positives = 445/1098 (40%), Gaps = 232/1098 (21%)
Query: 230 EGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNV 289
E F +++ EL + E + K+L E+M L +E +L+ V + E L ER + +
Sbjct: 860 EEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKI 919
Query: 290 RLTCLVAELQKQWE-----------VTQATQNTVKELQTCLQGLELGAAEKEEDYHTALR 338
+L + E+ ++ E + ++ EL+ + LEL A+ E++ H
Sbjct: 920 QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 979
Query: 339 RLESMLQPLA------------------------QELEATRDSLD-------KKNQHLAS 367
+++++ + +A +L+A D ++ K Q +
Sbjct: 980 KVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD 1039
Query: 368 FPGWLA--------MAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEE 419
G L + + K D K QE I D E Q+L EKL+ E E + ++
Sbjct: 1040 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESI-MDIENEKQQLDEKLKKKEFEISNLQS 1098
Query: 420 VNRQQSA---QLEQLVKELQLK-EDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQE 475
+ A QL++ +KELQ + E+ +E A +++ S +E +++ RL+E
Sbjct: 1099 KIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158
Query: 476 LLAHTSSW-------EEELAELRRE---------------KKQQQEEKELLEQEVRSLTR 513
TS+ E E ++RR+ +K+ + L +++ +L R
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218
Query: 514 QLQFLETQLAQVSQHVSDL-------------------------------EEQKKQLIQD 542
Q LE + +++ + DL EE++++LI D
Sbjct: 1219 VKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND 1278
Query: 543 KDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQR--------- 593
L+ Q G L+ +G +L ++ EALV S ++A+ + EE +
Sbjct: 1279 ---LTAQRGRLQTESGEFSRQL----DEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKA 1331
Query: 594 ------GLQEAQLDDTKVQEGSQEEE---------LRQANREL----EKELQNVVGRNQL 634
LQ ++ D ++E +EE+ L +AN E+ K + + R +
Sbjct: 1332 KNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEE 1391
Query: 635 LEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQ 694
LE + L QA ++ A+ ASLE + +++ + + + A A+ +
Sbjct: 1392 LEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKK 1451
Query: 695 MAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKG-- 752
+ IL + +C++ E+E Q+ A + EL +++ ++ +E L E
Sbjct: 1452 QRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNL 1511
Query: 753 QQGVGPPT--------------------DNEARELAAQLALSQAQLEVHQGEVQRLQAQV 792
QQ + T + E EL A L ++A LE +G++ R+Q ++
Sbjct: 1512 QQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLEL 1571
Query: 793 VDLQAKMRAALDDQDK------------VQSQLSMAEAVLREHKTLVQQLKEQNEALN-- 838
+++++ + ++D+ V+S S +A +R ++ K+ LN
Sbjct: 1572 NQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1631
Query: 839 ----------------------------RAHVQELLQCSE---REGALQEERADEAQQRE 867
+ H+ + L+ E + A+ E RA+ Q
Sbjct: 1632 EIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEI 1691
Query: 868 EELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALA 927
EELRA E+ +++ +E+ L+ +E + LH NT + L + +++ +
Sbjct: 1692 EELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK---LETDISQMQGEME 1748
Query: 928 CAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQ 987
+QE ++A+E A + L++E+++ + K ++ LQ +L +AEQ
Sbjct: 1749 DILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQ 1808
Query: 988 RAQSLQEAAHQELNTLKFQLSAEIMDYQSR-------LKNAGEECKSLRGQLEEQGRQLQ 1040
A + Q+L +L E+ Q R L+ K L Q EE + +
Sbjct: 1809 LALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNIL 1868
Query: 1041 AAEEAVEKLKA------TQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKE 1094
++ V+KL+A QA+ E+ S T +LA+ + L+ + E A R D+ +Q
Sbjct: 1869 RLQDLVDKLQAKVKSYKRQAEEAEEQSNT--NLAKFR--KLQHELEEAEERADIAESQ-- 1922
Query: 1095 LEKATTKIQEYYNKLCQE 1112
+ K K +E + K+ E
Sbjct: 1923 VNKLRVKSREVHTKVISE 1940
Score = 137 bits (345), Expect = 8e-32
Identities = 178/827 (21%), Positives = 346/827 (41%), Gaps = 101/827 (12%)
Query: 394 SDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKE---LQLK--------EDAR 442
++ +EM + E+ Q ++ E K E ++ ++ L+KE LQL+ DA
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 443 ASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRRE-------KK 495
++L+K L+ ++ + A+ EL A E+E +EL+++
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968
Query: 496 QQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLER 555
+ ++EK E +V++LT ++ L+ +A++++ L+E +Q + D +V L +
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1028
Query: 556 LAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLD----DTKVQEGSQE 611
++ E + L+ A K E + + QE+ +D ++ E ++
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKK 1088
Query: 612 EELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIR 671
+E +N + + E + +G L+ K++ LQA + L++ A + S A E +++ +
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQ--LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146
Query: 672 H---------------------LGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGEC- 709
+ + EA +R+ E Q A L+ K +
Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206
Query: 710 QQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAA 769
+L E+++ Q++ + +E ++ + +E ++ KG + R L
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGN------LEKMCRTLED 1260
Query: 770 QLALSQAQLEVHQGEVQRLQAQVVDLQAK---MRAALDDQDKVQSQLSMA-EAVLREHKT 825
QL+ +++ E Q + L AQ LQ + LD+++ + SQLS +A ++ +
Sbjct: 1261 QLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE 1320
Query: 826 LVQQLKEQNEALNR-AHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSS 884
L +QL+E+ +A N AH ALQ R D RE+
Sbjct: 1321 LKRQLEEEIKAKNALAH------------ALQSSRHDCDLLREQY--------------- 1353
Query: 885 EEAQLEHAELQEQLHRANTDTAELGIQVCALTVEK-ERVEEALACAVQELQDAKE---AA 940
EE Q AELQ L +ANT+ A+ + +++ E +EEA Q LQ A+E A
Sbjct: 1354 EEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAV 1413
Query: 941 SREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQEL 1000
+ + LE+ LQ E E L ++ AA +L Q + + E H EL
Sbjct: 1414 NAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAEL 1473
Query: 1001 NTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKL 1060
Q ++ G E ++ EE QL+ + + L+ +D+ E++
Sbjct: 1474 EAS-----------QKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQI 1522
Query: 1061 SCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERND 1120
+ + E + + ++E L+ LE + LE KI +L Q + +R
Sbjct: 1523 AEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI 1582
Query: 1121 QKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAE 1167
+ ++D L R + E + L + + ++DA+ ++K+ +
Sbjct: 1583 AEKDEEIDQLKRNHIRIVESMQSTLDAE--IRSRNDAIRLKKKMEGD 1627
Score = 97.1 bits (240), Expect = 1e-19
Identities = 139/659 (21%), Positives = 269/659 (40%), Gaps = 106/659 (16%)
Query: 605 VQEGSQEEELRQANRELEK---ELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLA 661
++ E+E+ E +K EL + + LE K+ L + LQ + A LA
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905
Query: 662 SLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQ 721
E + Q+EA + V + E + AE A + E EC +L+++++ +
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 722 LAEARHRELRALESQCQQQT-------QLIEVLTAEKG--QQGVGPPTDNEARELAAQLA 772
+E A E++ + T + I LT EK Q+ D+ E
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 773 LSQAQLEVHQ---------------------------GEVQRLQAQVVDLQAKMRAALDD 805
L++A++++ Q G+++ Q ++D++ + + +
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 806 QDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGA----LQEERAD 861
K + ++S ++ + + + L QL+++ + L +A ++EL + E E A +++R+D
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKEL-QARIEELEEEIEAERASRAKAEKQRSD 1144
Query: 862 EAQQREEELRALQE-----------------ELSQAKCSSEEAQLEHAELQEQLHRANTD 904
+++ EE L+E E + + EEA L+H L + + D
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Query: 905 T-AELGIQVCALTVEKERVE----------EALACAVQELQDAKEAASREREGLERQVAG 953
+ AELG Q+ L K+++E + LA V+ + AK + LE Q++
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSE 1264
Query: 954 LQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSL-------QEAAHQELNTLKFQ 1006
L+ ++E Q + A G L + ++ ++L ++A Q++ LK Q
Sbjct: 1265 LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ 1324
Query: 1007 LSAEIMDYQS---RLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSC- 1062
L EI + L+++ +C LR Q EE+ + A+ K A K
Sbjct: 1325 LEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETD 1384
Query: 1063 ---TSNHLAECQAAMLRK-----------DKEGAALREDLERTQKELEKATTKIQEYYNK 1108
+ L E + + ++ + + A+L + +R Q E+E + E N
Sbjct: 1385 AIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDV-ERTNA 1443
Query: 1109 LCQEVTNRERNDQKMLADLD--------DLNRTKKYLEERLIELLRDKDALWQKSDALE 1159
C + ++RN K+LA+ +L ++K EL + K+A + D LE
Sbjct: 1444 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLE 1502
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 150 bits (378), Expect = 1e-35
Identities = 181/777 (23%), Positives = 357/777 (45%), Gaps = 82/777 (10%)
Query: 399 EMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEE 458
E++ L L A E +R ++EE + + + L +LQ ++D A E + + +
Sbjct: 904 ELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQ 963
Query: 459 LSGKGQEADQLWRRLQE----LLAHTSSWEEELAELRRE-------KKQQQEEKELLEQE 507
L GK +E + +E L A E+E EL+++ + ++EK+ E +
Sbjct: 964 LEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENK 1023
Query: 508 VRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERL---AGPPGPEL 564
V++LT ++ L+ +A++++ L+E +Q + D +V L + +L
Sbjct: 1024 VKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDL 1083
Query: 565 PVAGEKNEAL-VPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEK 623
+ E+ + L + + ++ G + Q + +A D +++E ++++ + L
Sbjct: 1084 ECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRV 1143
Query: 624 ELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQA-SIRHLGDQMEASLL 682
E + ++G ++ K++ LQA + L++ A + + A +E ++A + R L + E
Sbjct: 1144 EDEQLLGAQ--MQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSE---- 1197
Query: 683 AVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELR--------ALE 734
+ +EA A ++E + +E E +LR E+E+ EA LR L
Sbjct: 1198 ---RLEEAGGASAGQREG-CRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELG 1253
Query: 735 SQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQL-------ALSQAQLEVHQGEVQR 787
Q ++ + L EK + + E +LAA + A ++ ++ ++
Sbjct: 1254 EQVDSLQRVRQKLEKEKSELRM------EVDDLAANVETLTRAKASAEKLCRTYEDQLSE 1307
Query: 788 LQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQ 847
+ +V +LQ ++ A + ++Q++ +L E + L+ QL + +AL ++EL +
Sbjct: 1308 AKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQL-SRGKALAAQSLEELRR 1366
Query: 848 CSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAE 907
E E + A Q + L+E+ EEA+ + AELQ L +AN + A+
Sbjct: 1367 QLEEESKAKSALAHAVQALRHDCDLLREQ------HEEEAEAQ-AELQRLLSKANAEVAQ 1419
Query: 908 LGIQVCALTVEK-ERVEEA---LACAVQELQDAKEAASREREGLERQVAGLQQEKESLQE 963
+ A +++ E +EEA LA +QE ++ EAA+ + LE+ LQ E E +
Sbjct: 1420 WRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTL 1479
Query: 964 KLKAAKAAAGSLPGLQAQLAQA-------EQRAQSLQEAAHQE---LNTLKFQLSAEIMD 1013
+L+ A +AA +L Q L +A E+ Q EAA +E L T F+L +
Sbjct: 1480 ELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEE 1539
Query: 1014 YQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADM-GEKLSCTSNHLAECQA 1072
L+ E K+L+ ++ + Q+ + +++++L+ T+ + GEK +E QA
Sbjct: 1540 ALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEK--------SEIQA 1591
Query: 1073 AMLRKDKEGAALREDLE--RTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADL 1127
A+ ++ EGA E+ + R Q EL + ++ + +E N RN Q+ + L
Sbjct: 1592 AL--EEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESL 1646
Score = 149 bits (377), Expect = 1e-35
Identities = 207/954 (21%), Positives = 403/954 (42%), Gaps = 109/954 (11%)
Query: 235 MRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCL 294
+R L E + ++L E + +E +L + + + L ER + V+L
Sbjct: 908 LRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGK 967
Query: 295 VAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEAT 354
V EL ++ E + +L + LE E ++D + L+ L +E +AT
Sbjct: 968 VKELSERLEDEEEVN---ADLAARRRKLEDECTELKKD----IDDLKLTLAKAEKEKQAT 1020
Query: 355 RDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERER 414
+ + + +A A+ + A + K QE A ++Q +++ AL + +
Sbjct: 1021 ENKVKNLTEEMA------ALDESVARLTKEKKALQEA-HQQALGDLQAEEDRVSALTKAK 1073
Query: 415 TKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQ 474
++E+ LEQ E +L+ D + +L ++ QE ++ Q+ QL +L+
Sbjct: 1074 LRLEQQVEDLECSLEQ---EKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLK 1130
Query: 475 ELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEE 534
+ + EL++L + +Q ++++++ L + + LE +L + +E+
Sbjct: 1131 KK-------DSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEK 1183
Query: 535 QKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRG 594
Q+ + ++ + LS++ LE G + ++ L + L+EA + E
Sbjct: 1184 QRAEAARELEELSER---LEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAA 1240
Query: 595 LQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRES 654
L+ Q + + G Q + L++ ++LEKE L ++ L A+ + L + ++
Sbjct: 1241 LRRKQAEGA-AELGEQVDSLQRVRQKLEKEKSE-------LRMEVDDLAANVETLTRAKA 1292
Query: 655 AIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQL-R 713
+ + + E + + + ++++ L + ++ + E +L+ KE QL R
Sbjct: 1293 SAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSR 1352
Query: 714 EEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLAL 773
+ Q L E R R LE + + ++ L + A + + RE + A
Sbjct: 1353 GKALAAQSLEELR----RQLEEESKAKSALAHAVQALRHDCDL-------LREQHEEEAE 1401
Query: 774 SQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQ 833
+QA+L Q + + A+V ++K A D +Q + EA K L +L+E
Sbjct: 1402 AQAEL---QRLLSKANAEVAQWRSKYEA-----DAIQRTEELEEA----KKKLALRLQEA 1449
Query: 834 NEALNRAHVQELLQCSEREGA---LQEERAD---EAQQREEELRALQEELSQAKCSSEEA 887
E + A+ + CS E A LQ E D E ++ AL ++ + + EE
Sbjct: 1450 EEGVEAANAK----CSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEER 1505
Query: 888 QLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGL 947
+ + E+Q +L A ++ LG ++ L E EAL E RE + L
Sbjct: 1506 RRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEAL-----------ETLKRENKNL 1554
Query: 948 ERQVAGLQQEK----ESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTL 1003
+ +++ L + +S+QE K KA G +QA L +AE A L+E +
Sbjct: 1555 QEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEG-ALELEETKTLRIQLE 1613
Query: 1004 KFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAA--------EEAVEKLKATQAD 1055
Q+ AE+ +L EEC +LR + LQA+ EA+ K + D
Sbjct: 1614 LSQVKAEV---DRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGD 1670
Query: 1056 MGE---KLSCTSNHLAECQAA---MLRKDKEGAALREDLERTQKELEKATTKIQEYYNKL 1109
+ + +L + E QAA M + KE A R++ +R EL + ++ + L
Sbjct: 1671 LNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLL 1730
Query: 1110 CQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQK 1163
E+ +++ A L+ R+++ E+ L+E + L ++ L Q+K
Sbjct: 1731 AAEL-------EELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKK 1777
Score = 148 bits (373), Expect = 4e-35
Identities = 237/1044 (22%), Positives = 421/1044 (40%), Gaps = 215/1044 (20%)
Query: 241 QLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQK 300
QLE + K+L ER++ + N +L AA ++ E TE ++ D+++LT AE +K
Sbjct: 963 QLEGKVKELSERLEDEEEVNADL-AARRRKLEDECTELKKDI----DDLKLTLAKAEKEK 1017
Query: 301 QWEVTQATQNTVKELQTCLQGLE--------------------LGAAEKEEDYHTALRRL 340
Q AT+N VK L + L+ LG + EED +AL +
Sbjct: 1018 Q-----ATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKA 1072
Query: 341 ESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEM 400
+ L+ ++LE + + K + + K D K QE + +DAAQ+
Sbjct: 1073 KLRLEQQVEDLECSLEQEKKLR---------MDTERAKRKLEGDLKLTQESV-ADAAQDK 1122
Query: 401 QELGEKLQALERERTKVE---EVNRQQSAQLEQLVKELQLK-EDARASLERLVKEMAPLQ 456
Q+L EKL+ + E +++ E + AQ+++ +KELQ + E+ LE A ++
Sbjct: 1123 QQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVE 1182
Query: 457 EELSGKGQEADQLWRRLQELLAHTSSWEE-------ELAELRRE---------------K 494
++ + +E ++L RL+E ++ E EL LRRE +
Sbjct: 1183 KQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALR 1242
Query: 495 KQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDK----------- 543
++Q E L ++V SL R Q LE + +++ V DL + L + K
Sbjct: 1243 RKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYE 1302
Query: 544 DHLSQ-----------------QVGMLERLAGPPGPELPVAGEKNEALVPVNS------- 579
D LS+ Q G L+ +G EL E+ E L+ S
Sbjct: 1303 DQLSEAKIKVEELQRQLADASTQRGRLQTESG----ELSRLLEEKECLISQLSRGKALAA 1358
Query: 580 -SLQEAWGKPEEEQRG-------LQEAQLDDTKVQEGSQEEE---------LRQANREL- 621
SL+E + EEE + +Q + D ++E +EE L +AN E+
Sbjct: 1359 QSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVA 1418
Query: 622 ---EKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQME 678
K + + R + LE + L Q ++ A +SLE + ++ + +
Sbjct: 1419 QWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVT 1478
Query: 679 ASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQ 738
L A A+ + E L+ + + ++++ E+E Q+ + EL L +
Sbjct: 1479 LELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHE 1538
Query: 739 QQTQLIEVLTAEKG--QQGVGPPTDN--------------------EARELAAQLALSQA 776
+ + +E L E Q+ + TD E E+ A L ++
Sbjct: 1539 EALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEG 1598
Query: 777 QLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEA 836
LE+ + + R+Q ++ ++A++ L ++D+ + L R H+ V+ L+ +A
Sbjct: 1599 ALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLR------RNHQRAVESLQASLDA 1652
Query: 837 LNRAHVQELLQCSEREGALQE------ERADEAQQREEELRALQEELSQAKCSSEEAQLE 890
RA + L + EG L + +A + + R +Q +L + + +E Q
Sbjct: 1653 ETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRL 1712
Query: 891 HAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAAS--------- 941
AEL EQ + L ++ L E+ E + A QEL +A E +
Sbjct: 1713 AAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGL 1772
Query: 942 -REREGLERQVAGLQ-------QEKESLQEKLKAA------------------------- 968
+++ LE +A L QE+ +EK K A
Sbjct: 1773 LNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1832
Query: 969 KAAAGSLPGLQAQLAQAEQRA----QSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGE- 1023
K ++ LQA+L +AEQ A + + ++ L+ +L AE + LK +
Sbjct: 1833 KTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKH 1892
Query: 1024 --ECKSLRGQLEEQGRQLQAAEEAVEKL----KATQADMGEKLSCTSNHLAECQAAMLRK 1077
K L Q EE + L ++ V+KL K+ + E + +LA+ + A +
Sbjct: 1893 ERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKA--QH 1950
Query: 1078 DKEGAALREDLERTQKELEKATTK 1101
+ + A R D+ TQ +A T+
Sbjct: 1951 ELDDAEERADMAETQANKLRARTR 1974
Score = 128 bits (321), Expect = 5e-29
Identities = 171/772 (22%), Positives = 327/772 (42%), Gaps = 76/772 (9%)
Query: 417 VEEVNRQQSAQLEQLVKELQLKEDARASLERLV---KEMAPLQEELSGKGQEADQLWRRL 473
+EE+ Q+ A++ L++ R +RL+ + +Q + + W +L
Sbjct: 822 LEELRDQRLAKVLTLLQARSRGRLMRLEYQRLLGGRDALFTIQWNIRAFNAVKNWSWMKL 881
Query: 474 ---QELLAHTSSWEEELAELRREKK-------QQQEEKELLEQEVRSLTRQLQFLETQLA 523
+ L ++ EEELA LR E + + +++ LE+ S+T++ L QL
Sbjct: 882 FFKMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQ 941
Query: 524 QVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQE 583
+++D EE+ LI+ K L +V L E+ E VN+ L
Sbjct: 942 AEQDNLADAEERCHLLIKSKVQLEGKVKELS--------------ERLEDEEEVNADLAA 987
Query: 584 AWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQ 643
K E+E L++ +DD K+ E+E +QA E +++N+ L+ + L
Sbjct: 988 RRRKLEDECTELKK-DIDDLKLTLAKAEKE-KQAT---ENKVKNLTEEMAALDESVARLT 1042
Query: 644 ADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQ 703
+ +ALQ+ G L + E +++ ++E + + + E K + E +
Sbjct: 1043 KEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKR 1102
Query: 704 SKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNE 763
EG+ + +E V Q + +L+ +S+ Q + +E +Q +G +
Sbjct: 1103 KLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVE------DEQLLGAQMQKK 1156
Query: 764 ARELAAQLALSQAQLEVHQG-----EVQRLQA--QVVDLQAKMRAA-------LDDQDKV 809
+EL A+ + +LE + E QR +A ++ +L ++ A + K
Sbjct: 1157 IKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKR 1216
Query: 810 QSQLS-----MAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQ 864
+++L + EA LR T+ ++Q E A + E + +R E+ E +
Sbjct: 1217 EAELGRLRRELEEAALRHEATVAALRRKQAEGA--AELGEQVDSLQRVRQKLEKEKSELR 1274
Query: 865 QREEELRALQEELSQAKCSSE-----------EAQLEHAELQEQLHRANTDTAELGIQVC 913
++L A E L++AK S+E EA+++ ELQ QL A+T L +
Sbjct: 1275 MEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTE-- 1332
Query: 914 ALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAG 973
+ E R+ E C + +L K A++ E L RQ+ + K +L ++A +
Sbjct: 1333 --SGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCD 1390
Query: 974 SLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLE 1033
L + A+A+ Q L A+ E+ + + A+ + L+ A ++ +LR Q
Sbjct: 1391 LLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKL-ALRLQEA 1449
Query: 1034 EQGRQLQAAE-EAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQ 1092
E+G + A+ ++EK K E ++ AA+ +K + E+ R +
Sbjct: 1450 EEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQE 1509
Query: 1093 KELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIEL 1144
+E+++ Q L E+ ++ L L+ L R K L+E + +L
Sbjct: 1510 EEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDL 1561
Score = 115 bits (289), Expect = 2e-25
Identities = 176/784 (22%), Positives = 334/784 (42%), Gaps = 87/784 (11%)
Query: 224 LNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRT 283
L + EG E+ ++D L+ ++L + +L E +L A V + + RT
Sbjct: 1241 LRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRT 1300
Query: 284 AAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESM 343
+ V ELQ+Q + ++ L L E++E + L R +++
Sbjct: 1301 YEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRL----LEEKECLISQLSRGKAL 1356
Query: 344 LQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQEL 403
AQ LE R L+++++ ++ LA A Q D Q ++A E+Q L
Sbjct: 1357 A---AQSLEELRRQLEEESKAKSA----LAHAVQALRHDCDLLREQHEEEAEAQAELQRL 1409
Query: 404 GEKLQA-LERERTKVEEVNRQQSAQLEQLVKELQLK--------EDARASLERLVKEMAP 454
K A + + R+K E Q++ +LE+ K+L L+ E A A L K
Sbjct: 1410 LSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLR 1469
Query: 455 LQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQ 514
LQ E E ++ L E L E RR++++ Q E E ++E R L +
Sbjct: 1470 LQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTE 1529
Query: 515 LQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELP-----VAGE 569
L L + + + L+ + K L ++ L+ QV L+G EL + GE
Sbjct: 1530 LFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVS----LSGKSIQELEKTKKALEGE 1585
Query: 570 KNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVV 629
K+E + ++L+EA G E E+ QL+ ++V+ E+ + E ++E N+
Sbjct: 1586 KSE----IQAALEEAEGALELEETKTLRIQLELSQVKA-----EVDRKLAEKDEECANLR 1636
Query: 630 GRNQLLEGKLQA-LQADYQALQQR---ESAIQGSLASLEAEQASIRHLGDQMEASLLAVR 685
+Q LQA L A+ +A + + ++G L LE + + +A
Sbjct: 1637 RNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQA------ 1690
Query: 686 KAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAE---ARHRELRALESQCQQQTQ 742
A M+AQ+ E++A ++ +L E+ + ++ A A ELRA Q ++ +
Sbjct: 1691 -ATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRR 1749
Query: 743 LIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAA 802
L E E E +L L +Q + ++L+A + L ++ A
Sbjct: 1750 LAE----------------QELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEA 1793
Query: 803 LDDQDKVQSQLSMAEAVLREHKTLVQQLK-EQNEALNRAHVQELLQCSEREGALQEERAD 861
++ + + + A+ + + + ++LK EQ+ + + +++ L+ + RE + E A+
Sbjct: 1794 AQERREAEEK---AKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAE 1850
Query: 862 EAQQR--EEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEK 919
+A R +++++ L+ ++ + + + Q +HAE + + + EL Q E+
Sbjct: 1851 QAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQ-----AEE 1905
Query: 920 ERVEEA-LACAVQELQDAKEAASREREGLERQV-------AGLQQEKESLQEKLKAAKAA 971
+R A + V +LQ ++ R+ E E+Q Q E + +E+ A+
Sbjct: 1906 DRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQ 1965
Query: 972 AGSL 975
A L
Sbjct: 1966 ANKL 1969
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 149 bits (377), Expect = 1e-35
Identities = 196/921 (21%), Positives = 385/921 (41%), Gaps = 111/921 (12%)
Query: 234 EMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVR--- 290
++ + D LE +Q ++ L+R ++L + E + + E + E+ ++
Sbjct: 1030 KLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIM-DLENDKQQIEEKLKKKE 1088
Query: 291 --LTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLA 348
L+ L A++ + + Q +KELQ ++ LE E+ E HT ++E LA
Sbjct: 1089 FELSQLQAKIDDEQVHSLQFQKKIKELQARIEELE----EEIEAEHTLRAKIEKQRSDLA 1144
Query: 349 QELE-----------ATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAA 397
+ELE AT ++ + A F M + + + + A
Sbjct: 1145 RELEEISERLEEASGATSAQIEMNKKREAEFQ---KMRRDLEEATLQHEATAATLRKKQA 1201
Query: 398 QEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQE 457
+ ELGE++ L+R + K+E+ + +++ + ++ +++++ER + +
Sbjct: 1202 DSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFS 1261
Query: 458 ELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKK----QQQEEKELLEQEVRSLTR 513
E+ K ++ QL L A + EL+ EK+ Q + K+ L Q++ L R
Sbjct: 1262 EIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKR 1321
Query: 514 QLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQV-GMLERLAGPPGPELPV------ 566
Q++ ET+ H L++++ Q+ L+R E+
Sbjct: 1322 QME-EETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYE 1380
Query: 567 --AGEKNEALVPVNSSLQEAWGKPEE--EQRGLQEAQLDDTKVQ-EGSQEEELRQANRE- 620
A ++ E L L + + EE E + A L+ TK + +G E+ +R R
Sbjct: 1381 TDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSH 1440
Query: 621 -----LEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQ--------------GSLA 661
L+K+ +N + KL QA+ +A Q+ ++ L
Sbjct: 1441 TACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLE 1500
Query: 662 SLEAE----QASIRHLGDQME---ASLLAVRKAKEAMKAQMAEKEAILQSKEG-----EC 709
+L E Q I L +Q+ +L K K+ ++ + ++ + L+ EG E
Sbjct: 1501 TLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEES 1560
Query: 710 QQLREEVEQCQQLAE------ARHRELRALESQCQQQTQLIE-VLTAEKGQQG----VGP 758
+ LR ++E Q +E + E+ L+ Q+ + ++ VL AE + +
Sbjct: 1561 KILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKK 1620
Query: 759 PTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEA 818
+ + E+ QL S Q+ Q ++ +Q Q+ D Q + AL + ++ QL++ E
Sbjct: 1621 KMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVE- 1679
Query: 819 VLREHKTLVQQLK------EQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRA 872
R + L+++L+ EQ E R QELL S+R L + +++
Sbjct: 1680 --RRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKK---- 1733
Query: 873 LQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCA---LTVEKERVEEALACA 929
L+ +++Q + E + E +E+ +A TD A + ++ + ER+++ L
Sbjct: 1734 LEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQT 1793
Query: 930 VQELQD-AKEAASREREGLERQVAGLQQEKESLQEKLKA-AKAAAGSLPGLQAQLAQAEQ 987
V++LQ EA +G ++Q+ L+ L+ +L K A +L G + ++
Sbjct: 1794 VKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKE 1853
Query: 988 RAQSLQEAAHQ--ELNTLKFQLSAEIMDYQSRLKNAGEE-------CKSLRGQLEEQGRQ 1038
+E L L +L A++ Y+ + + A E+ C+ ++ +LEE +
Sbjct: 1854 MTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAER 1913
Query: 1039 LQAAEEAVEKLKATQADMGEK 1059
AE V KL+A D+G +
Sbjct: 1914 ADIAESQVNKLRAKSRDVGSQ 1934
Score = 147 bits (371), Expect = 7e-35
Identities = 214/993 (21%), Positives = 417/993 (41%), Gaps = 131/993 (13%)
Query: 230 EGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNV 289
E F+ + EL + E R K+L E+M L +E +L+ V + E L ER + +
Sbjct: 858 EDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKI 917
Query: 290 RLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQ 349
L V EL ++ E + + EL + LE + + D + LE L + +
Sbjct: 918 LLEAKVKELTERLEEEEEMNS---ELVAKKRNLEDKCSSLKRD----IDDLELTLTKVEK 970
Query: 350 ELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQA 409
E AT + + ++ + A+ + + + K QE ++Q +K+
Sbjct: 971 EKHATENKVKNLSEEMT------ALEENISKLTKEKKSLQE-AHQQTLDDLQVEEDKVNG 1023
Query: 410 LERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQL 469
L + K+E+ LEQ E +L+ D + +L ++ QE + + Q+
Sbjct: 1024 LIKINAKLEQQTDDLEGSLEQ---EKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQI 1080
Query: 470 WRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHV 529
+L++ E EL++L+ + +Q +++++ L +++ LE ++
Sbjct: 1081 EEKLKKK-------EFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLR 1133
Query: 530 SDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPE 589
+ +E+Q+ L ++ + +S++ LE +G ++ + ++ + L+EA + E
Sbjct: 1134 AKIEKQRSDLARELEEISER---LEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHE 1190
Query: 590 EEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQ------ 643
L++ Q D + G Q + L++ ++LEKE + + ++AL
Sbjct: 1191 ATAATLRKKQADSV-AELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNI 1249
Query: 644 -----------ADYQALQQRESAIQGSL----ASLEAEQASIRHLGDQMEASLLAVRKAK 688
++ +A ++++ + L A L+ + + H ++ E+ + + K+K
Sbjct: 1250 ERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSK 1309
Query: 689 EAMKAQMAE-----------KEAI---LQSKEGECQQLREEVEQCQQLAEARHRELRALE 734
+A+ Q+ E K A+ LQS +C LRE+ E+ Q+ R L
Sbjct: 1310 QALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKAN 1369
Query: 735 SQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEV-------QR 787
S+ Q E ++ ++ + ++LA +L ++ E + QR
Sbjct: 1370 SEVAQWRTKYETDAIQRTEE-----LEEAKKKLAQRLQEAEENTETANSKCASLEKTKQR 1424
Query: 788 LQAQVVDLQAKMR------AALDDQ----DKV---------QSQLSMAEAVLREHKTLVQ 828
LQ +V DL + A LD + DKV +SQ + EA +E ++L
Sbjct: 1425 LQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAEL-EAAQKESRSLST 1483
Query: 829 QLKEQNEALNRAHVQELLQCSEREGA-LQEERADEAQQREEELRALQEELSQAKCSSEEA 887
+L + A V + L+ RE LQEE +D +Q E + LQE A+ + +
Sbjct: 1484 ELFKMRNAYE--EVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQE----AEKTKKLV 1537
Query: 888 QLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAV----QELQDAKEAASRE 943
+ E ++LQ L ++ + +E +V+ L V +E++ K + R
Sbjct: 1538 EQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRA 1597
Query: 944 REGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTL 1003
E L+ + L E S + L+ K G L ++ QL + ++ Q + L T+
Sbjct: 1598 AEALQ---SVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQ----KHLRTV 1650
Query: 1004 KFQLSAEIMDYQSRLKNAGEECKSLRGQL----EEQGRQLQAAEE---AVEKLKATQADM 1056
+ QL D Q L +A + L+ QL G L+ EE A+E+ + T+
Sbjct: 1651 QGQLK----DSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLS 1706
Query: 1057 GEKLSCTSN--HLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVT 1114
++L S+ L Q L K+ L D+ + Q E+E + + + K + +T
Sbjct: 1707 EQELLDASDRVQLLHSQNTSLINTKK--KLEADIAQCQAEVENSIQESRNAEEKAKKAIT 1764
Query: 1115 NRERNDQKMLADLD---DLNRTKKYLEERLIEL 1144
+ +++ + D L R KK LE+ + +L
Sbjct: 1765 DAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1797
Score = 142 bits (359), Expect = 2e-33
Identities = 193/859 (22%), Positives = 366/859 (42%), Gaps = 92/859 (10%)
Query: 324 LGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTAS 383
L +AE E++ T E + LA+ EA R L++K +++ Q+K D
Sbjct: 844 LKSAEAEKEMATMKEDFERTKEELARS-EARRKELEEK---------MVSLLQEKNDLQL 893
Query: 384 DTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARA 443
+ E + DA + + L + LE + ++ E ++ +LV + + ED +
Sbjct: 894 QVQSETENL-MDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCS 952
Query: 444 SLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKEL 503
SL+R + + L+ L+ +E +++ L ++ EE +++L +EKK QE +
Sbjct: 953 SLKRDIDD---LELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQ 1009
Query: 504 LEQEVRSLTRQLQFLETQLAQVSQHVSDLE---EQKKQLIQDKDHLSQQVGMLERLAGPP 560
+++ ++ L A++ Q DLE EQ+K+L D LER
Sbjct: 1010 TLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRAD----------LERAKRKL 1059
Query: 561 GPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRE 620
+L ++ E L ++E K E E LQ A++DD +V ++++++
Sbjct: 1060 EGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQ-AKIDDEQVHSLQFQKKIKELQAR 1118
Query: 621 LEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEAS 680
+E EL+ + L K++ ++D L + I L ++ + + EA
Sbjct: 1119 IE-ELEEEIEAEHTLRAKIEKQRSD---LARELEEISERLEEASGATSAQIEMNKKREAE 1174
Query: 681 LLAVRKAKEAMKAQMAEKEAILQSKEGEC-QQLREEVEQCQQLAEARHRELRALESQCQQ 739
+R+ E Q A L+ K+ + +L E+++ Q++ + +E L+ +
Sbjct: 1175 FQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDD 1234
Query: 740 QTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKM 799
IE L+ K + R + Q + +A+ E + L Q LQ +
Sbjct: 1235 MASNIEALSKSKSN------IERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQ- 1287
Query: 800 RAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEER 859
+LS + E ++L+ QL + +AL + ++EL + E E +
Sbjct: 1288 ----------NGELSHR---VEEKESLISQLTKSKQALTQ-QLEELKRQMEEETKAKNAM 1333
Query: 860 ADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQ----VCAL 915
A Q + L+E+ EE Q AELQ L +AN++ A+ +
Sbjct: 1334 AHALQSSRHDCDLLREQY-------EEEQEAKAELQRALSKANSEVAQWRTKYETDAIQR 1386
Query: 916 TVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL 975
T E E ++ LA +QE ++ E A+ + LE+ LQ E E L L+ + A +L
Sbjct: 1387 TEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATL 1446
Query: 976 PGLQ-------AQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSL 1028
Q A+ Q +Q+ EAA +E +L +L +++NA EE
Sbjct: 1447 DKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELF--------KMRNAYEEVVD- 1497
Query: 1029 RGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDL 1088
QLE R+ + +E + +D+ E+++ T +L E + ++E + L+ L
Sbjct: 1498 --QLETLRRENKNLQEEI-------SDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVAL 1548
Query: 1089 ERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDK 1148
E + LE +KI +L Q + +R + +++ L R + E L +L +
Sbjct: 1549 EEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAE 1608
Query: 1149 DALWQKSDALEFQQKLSAE 1167
+ ++DAL ++K+ +
Sbjct: 1609 --IRSRNDALRLKKKMEGD 1625
Score = 140 bits (352), Expect = 1e-32
Identities = 209/956 (21%), Positives = 391/956 (40%), Gaps = 147/956 (15%)
Query: 249 LRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQAT 308
L E + +L +E + L+ A Q + LQ E ++ + N +L +L+ E +
Sbjct: 989 LEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKL 1048
Query: 309 QNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASF 368
+ ++ + L+G + E D +++E L+ EL + +D + H F
Sbjct: 1049 RADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQF 1108
Query: 369 PGWLAMAQQKADTASDT-------KGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVN 421
+ Q + + + + + E SD A+E++E+ E+L+ + E+N
Sbjct: 1109 QKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMN 1168
Query: 422 RQQSAQLEQLVKELQ---LKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLA 478
+++ A+ +++ ++L+ L+ +A A+ R K+ A EL G++ D L R Q+L
Sbjct: 1169 KKREAEFQKMRRDLEEATLQHEATAATLR--KKQADSVAEL---GEQIDNLQRVKQKL-- 1221
Query: 479 HTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQ 538
E+E +EL+ E E L + ++ R + +E Q +++ +EQ+ Q
Sbjct: 1222 -----EKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAK----DEQQTQ 1272
Query: 539 LIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEA 598
LI D L+ Q L+ G EL E+ E+L+ +
Sbjct: 1273 LIHD---LNMQKARLQTQNG----ELSHRVEEKESLI----------------------S 1303
Query: 599 QLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQG 658
QL +K Q EEL++ E K + Q L+ Y+ Q+ ++ +Q
Sbjct: 1304 QLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQR 1363
Query: 659 SLASLEAEQASIR--HLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEV 716
+L+ +E A R + D ++ + + +AK+ + ++ E E ++ +C L +
Sbjct: 1364 ALSKANSEVAQWRTKYETDAIQRTE-ELEEAKKKLAQRLQEAEENTETANSKCASLEKTK 1422
Query: 717 EQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQA 776
++ Q E R+L + C T +K Q+ D E +L SQA
Sbjct: 1423 QRLQGEVEDLMRDLERSHTACA---------TLDKKQRNF----DKVLAEWKQKLDESQA 1469
Query: 777 QLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEA 836
+LE Q E + L ++ KMR A ++ V QL E + RE+K L +++ + E
Sbjct: 1470 ELEAAQKESRSLSTELF----KMRNAYEE---VVDQL---ETLRRENKNLQEEISDLTEQ 1519
Query: 837 LNRAHVQELLQCSEREGALQEERADEAQQREEELRA-----------LQEELSQAKCSSE 885
+ A + LQ +E+ L E+ + Q EE+ +Q ELSQ K +
Sbjct: 1520 I--AETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELD 1577
Query: 886 EAQLEHAELQEQLHRANT-----------------------------DTAELGIQVCALT 916
+E E EQL R + D E+ IQ+
Sbjct: 1578 RKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSN 1637
Query: 917 VEKERVEEALACAVQELQDAK---EAASREREGLERQVAGLQQEKESLQEKLKAAKAAAG 973
+ ++ L +L+D++ + A R E L+ Q+A +++ L E+L+ K A
Sbjct: 1638 RQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALE 1697
Query: 974 SLPGL----QAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRL-------KNAG 1022
+ +L A R Q L +NT K +L A+I Q+ + +NA
Sbjct: 1698 QTERTRRLSEQELLDASDRVQLLHSQNTSLINTKK-KLEADIAQCQAEVENSIQESRNAE 1756
Query: 1023 EECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEG- 1081
E+ K +L+ ++ L+ + ++ + + + L E + L+ K+
Sbjct: 1757 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQI 1816
Query: 1082 -------AALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDL 1130
L +L+ QK +A +Y K+ +E+T + D K + L DL
Sbjct: 1817 QKLENRVRELENELDVEQKRGAEALKGAHKYERKV-KEMTYQAEEDHKNILRLQDL 1871
Score = 137 bits (345), Expect = 8e-32
Identities = 179/855 (20%), Positives = 358/855 (41%), Gaps = 108/855 (12%)
Query: 394 SDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKE---LQLKE--------DAR 442
++A +EM + E + + E + E ++ ++ L++E LQL+ DA
Sbjct: 847 AEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAE 906
Query: 443 ASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKE 502
E L+K L+ ++ + ++ EL+A + E++ + L+R+ +
Sbjct: 907 ERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLT 966
Query: 503 LLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGP 562
+E+E + +++ L ++ + +++S L ++KK L +
Sbjct: 967 KVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLD-------------- 1012
Query: 563 ELPVAGEKNEALVPVNSSLQEAW----GKPEEEQRGLQEAQLDDTKVQ---EGSQEE--E 613
+L V +K L+ +N+ L++ G E+E++ + + K++ + SQE +
Sbjct: 1013 DLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMD 1072
Query: 614 LRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAE------- 666
L +++E++L+ L+ K+ Q Q++ +Q + LE E
Sbjct: 1073 LENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTL 1132
Query: 667 QASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEAR 726
+A I + L + + E + + + + +E E Q++R ++E+ EA
Sbjct: 1133 RAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1192
Query: 727 HRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQ---LALSQAQLEVHQG 783
LR +Q + E+ Q V + E EL + +A + L +
Sbjct: 1193 AATLRK-----KQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKS 1247
Query: 784 EVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLR-----------EHKTLVQQLKE 832
++R V D ++++A + Q ++ L+M +A L+ E ++L+ QL +
Sbjct: 1248 NIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTK 1307
Query: 833 QNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHA 892
+AL + ++EL + E E + A Q + L+E+ EE Q A
Sbjct: 1308 SKQALTQ-QLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQY-------EEEQEAKA 1359
Query: 893 ELQEQLHRANTDTAE----LGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLE 948
ELQ L +AN++ A+ T E E ++ LA +QE ++ E A+ + LE
Sbjct: 1360 ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLE 1419
Query: 949 RQVAGLQQEKESLQEKLKAAKAAAGSLPGLQ-------AQLAQAEQRAQSLQEAAHQELN 1001
+ LQ E E L L+ + A +L Q A+ Q +Q+ EAA +E
Sbjct: 1420 KTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESR 1479
Query: 1002 TLKFQL------SAEIMDYQSRL----KNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKA 1051
+L +L E++D L KN EE L Q+ E G+ LQ AE+ + ++
Sbjct: 1480 SLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQ 1539
Query: 1052 TQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQ 1111
++D+ L L ++ +LR E + ++ +L+R E ++ +++ + +
Sbjct: 1540 EKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAE 1599
Query: 1112 EVTN------RERND-----QKMLADLDDLNRTKKYLEERLIELLRD--------KDALW 1152
+ + R RND +KM DL+++ + ++ E + KD+
Sbjct: 1600 ALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQL 1659
Query: 1153 QKSDALEFQQKLSAE 1167
DAL + L +
Sbjct: 1660 HLDDALRSNEDLKEQ 1674
Score = 50.4 bits (119), Expect = 1e-05
Identities = 71/324 (21%), Positives = 134/324 (41%), Gaps = 54/324 (16%)
Query: 884 SEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASRE 943
S EA+ E A ++E R + A ++ +EE + +QE D + E
Sbjct: 846 SAEAEKEMATMKEDFERTKEELARS-------EARRKELEEKMVSLLQEKNDLQLQVQSE 898
Query: 944 REGL---ERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQEL 1000
E L E + GL + K L+ K+K + ++L ++ + + +++
Sbjct: 899 TENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDI 958
Query: 1001 NTLKFQLS---AEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMG 1057
+ L+ L+ E ++++KN EE +L + + ++ ++ +EA ++
Sbjct: 959 DDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEE 1018
Query: 1058 EKLSCTSNHLAECQAAMLRK--DKEGA-----ALREDLERTQKELEKATTKIQEYYNKLC 1110
+K+ N L + A + ++ D EG+ LR DLER +++LE QE
Sbjct: 1019 DKV----NGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQE------ 1068
Query: 1111 QEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSD-----ALEFQQKL- 1164
+ DL K+ +EE+L + + L K D +L+FQ+K+
Sbjct: 1069 ---------------SIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIK 1113
Query: 1165 ---SAEERWLGDTEANHCLDCKRE 1185
+ E + EA H L K E
Sbjct: 1114 ELQARIEELEEEIEAEHTLRAKIE 1137
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 147 bits (370), Expect = 1e-34
Identities = 185/933 (19%), Positives = 383/933 (41%), Gaps = 97/933 (10%)
Query: 212 QEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVS-QQ 270
Q+ + + + N + ++ ++D LE +Q ++ L+R ++L + Q
Sbjct: 1008 QQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQ 1067
Query: 271 GEQLQTERER---GRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLE---- 323
+ TE ++ + ++ L +++ + + Q +KELQ ++ LE
Sbjct: 1068 ESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIE 1127
Query: 324 ---LGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKAD 380
A+ E+ R LE + + L + AT ++ + A F M + +
Sbjct: 1128 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ---KMRRDLEE 1184
Query: 381 TASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKED 440
+ + + A + ELGE++ +L+R + K+E+ + ++ L ++
Sbjct: 1185 STLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSK 1244
Query: 441 ARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEE 500
A+A+ E++ + + E+ K +E +L + EL A + E E R+ ++
Sbjct: 1245 AKANFEKMCRTLEDQLSEIKTKEEEQQRL---INELSAQKARLHTESGEFSRQLDEKDAM 1301
Query: 501 KELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPP 560
L + ++ T+Q++ L+ QL + ++ S L + D D L +Q
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQY---------- 1351
Query: 561 GPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRE 620
E+ EA + LQ K E + D + EEL +A ++
Sbjct: 1352 -------EEEQEA----KAELQRGMSKANSEVAQWRTKYETDAI----QRTEELEEAKKK 1396
Query: 621 LEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEAS 680
L + LQ+ + + K +L+ Q LQ + ++ + +E A+ L D+ + +
Sbjct: 1397 LAQRLQDAEEHVEAVNSKCASLEKTKQRLQ---NEVEDLMIDVERSNAACIAL-DKKQRN 1452
Query: 681 LLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQ 740
K K + E +A L++ + E + L E+ + + E L L+ + +
Sbjct: 1453 F---DKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNL 1509
Query: 741 TQLIEVLTAEKGQQG--------VGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQV 792
Q I LT + + G V D+E EL L ++A LE +G++ R+Q ++
Sbjct: 1510 QQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLEL 1569
Query: 793 VDLQAKMRAALDDQDKVQSQL--SMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSE 850
+++++ + ++D+ QL + V TL +++ +N+AL +++ ++
Sbjct: 1570 NQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDAL---RIKKKMEGDL 1626
Query: 851 REGALQEERAD-EAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELG 909
E +Q A+ +A + LR Q L + ++A +L+EQL +
Sbjct: 1627 NEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQ 1686
Query: 910 IQVCALTVEKERVEEALACAVQELQDAKEAAS----------REREGLERQVAGLQQEKE 959
+V L ER E A QEL DA E ++ LE ++ +Q E E
Sbjct: 1687 AEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEME 1746
Query: 960 SLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLK 1019
+ ++ + A+ A A +A+ ++ Q +AH L +K + + D Q RL
Sbjct: 1747 DIVQEARNAEEKAKKAITDAAMMAEELKKEQ--DTSAH--LERMKKNMEQTVKDLQLRLD 1802
Query: 1020 NAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDK 1079
E + L+ ++ ++KL+A ++ ++ H E + + ++
Sbjct: 1803 -------------EAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHER 1849
Query: 1080 EGAAL-------REDLERTQKELEKATTKIQEY 1105
L R+++ R Q ++K TK++ Y
Sbjct: 1850 RVKELTYQTEEDRKNILRLQDLVDKLQTKVKAY 1882
Score = 140 bits (353), Expect = 9e-33
Identities = 217/1049 (20%), Positives = 421/1049 (40%), Gaps = 136/1049 (12%)
Query: 230 EGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNV 289
E F++ + EL + E + K+L E+M L +E +L+ V + + L ER + +
Sbjct: 858 EEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKI 917
Query: 290 RLTCLVAELQKQWE-----------VTQATQNTVKELQTCLQGLELGAAEKEEDYHTALR 338
+L + E+ ++ E + ++ EL+ + LEL A+ E++ H
Sbjct: 918 QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 977
Query: 339 RLESMLQPLAQELEATRDSLDKKNQHLASFPGW----LAMAQQKADTASDTKGRQEPIPS 394
+++++ + +A L+ T L K+ + L L M + K +T + K + E
Sbjct: 978 KVKNLTEEMA-GLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVD 1036
Query: 395 DAAQEMQELGEKLQALERERTKVE-EVNRQQSAQLEQLVKELQLKEDARASLERLVKEMA 453
D +++ + LER + K+E ++ Q + ++ + QL E L++ EM+
Sbjct: 1037 DLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNE----KLKKKEFEMS 1092
Query: 454 PLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTR 513
LQ ++ + A QL ++++EL A EEE+ R + + ++++ L +E+ ++
Sbjct: 1093 NLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISE 1152
Query: 514 QLQ----FLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGE 569
+L+ Q+ + ++ ++ ++ L + L + EL GE
Sbjct: 1153 RLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAEL---GE 1209
Query: 570 KNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVV 629
+ ++L V L E+++ + +++D S E + +A EK +
Sbjct: 1210 QIDSLQRVKQKL--------EKEKSELKMEINDL----ASNMETVSKAKANFEKMCRT-- 1255
Query: 630 GRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKE 689
LE +L ++ + Q+ + + A L E D+ +A + + + K+
Sbjct: 1256 -----LEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQ 1310
Query: 690 AMKAQMAEKEA--------------ILQSKEGECQQLREEVEQCQQLAEARHRELRALES 735
A Q+ E + LQS +C LRE+ E+ Q+ R + S
Sbjct: 1311 AFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANS 1370
Query: 736 QCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEV-------QRL 788
+ Q E ++ ++ + ++LA +L ++ +E + QRL
Sbjct: 1371 EVAQWRTKYETDAIQRTEE-----LEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRL 1425
Query: 789 QAQVVDLQ---AKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQEL 845
Q +V DL + AA DK Q A ++ Q E ++ +R+ EL
Sbjct: 1426 QNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTEL 1485
Query: 846 LQCSEREGALQEERADEAQQREEELRALQEELSQA------------KCSSEEAQLEH-- 891
+ EE D + + E + LQ+E+S + + QL+H
Sbjct: 1486 FKVKN----AYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEK 1541
Query: 892 AELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASRER-EGLERQ 950
+ELQ L A ++ + +E +V+ + + E + + R +E
Sbjct: 1542 SELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESM 1601
Query: 951 VAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAE 1010
+ L E S + L+ K G L ++ QL A ++A EA NT
Sbjct: 1602 QSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQA---AEALRNLRNT-----QGI 1653
Query: 1011 IMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKAT--QADMGEKLSCTSNHLA 1068
+ D Q L +A L+ QL R+ + VE+L+A+ + + G K++ A
Sbjct: 1654 LKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDA 1713
Query: 1069 ECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADL- 1127
+ +L L T+K+LE ++IQ + QE N E +K + D
Sbjct: 1714 SERVQLLHTQ------NTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAA 1767
Query: 1128 -------------DDLNRTKKYLEERLIEL---LRDKDALWQKSDALEFQQKLSAEERWL 1171
L R KK +E+ + +L L + + L K + QKL A R L
Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI-QKLEARVREL 1826
Query: 1172 G---DTEANHCLDCKREFSWMVRRHHCRI 1197
++E H ++ + +R+H R+
Sbjct: 1827 ESEVESEQKHNVEAVKG----LRKHERRV 1851
Score = 118 bits (295), Expect = 5e-26
Identities = 164/730 (22%), Positives = 314/730 (43%), Gaps = 99/730 (13%)
Query: 450 KEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKK----QQQEEKELL- 504
KEMA ++EE +E + + +EL EE++ L +EK Q Q E + L
Sbjct: 851 KEMANMKEEFEKTKEELAKTEAKRKEL-------EEKMVTLMQEKNDLQLQVQAEADALA 903
Query: 505 --EQEVRSLTRQLQFLETQLAQVSQHVSDLEE-------QKKQLIQDKDHLSQQVGMLER 555
E+ L + LE ++ +V++ D EE +K++L + L + + LE
Sbjct: 904 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 963
Query: 556 LAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQ---LDDTKVQEGSQEE 612
E K + L + L E K +E++ LQEA LDD +++E +
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEE-DKVN 1022
Query: 613 ELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRH 672
L +A +LE+++ + LEG L+ + L++ + ++G L A+++++
Sbjct: 1023 TLTKAKTKLEQQVDD-------LEGSLEQEKKLCMDLERAKRKLEGDLKL--AQESTMDT 1073
Query: 673 LGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRA 732
D K Q+ EK L+ KE E L+ ++E Q LA ++++
Sbjct: 1074 END----------------KQQLNEK---LKKKEFEMSNLQGKIEDEQALAIQLQKKIKE 1114
Query: 733 LESQCQQQTQLIEV-----LTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQR 787
L+++ ++ + IE AEK + + + + L + AQ+E+++
Sbjct: 1115 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1174
Query: 788 LQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQ 847
Q KMR L++ + A A+ ++H V +L EQ ++L R + +
Sbjct: 1175 FQ--------KMRRDLEESTLQHE--ATAAALRKKHADSVAELGEQIDSLQRVKQKLEKE 1224
Query: 848 CSEREGALQE-----ERADEAQQREEEL-RALQEELSQAKCSSEEAQLEHAELQEQLHRA 901
SE + + + E +A+ E++ R L+++LS+ K EE Q EL Q R
Sbjct: 1225 KSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARL 1284
Query: 902 NTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESL 961
+T++ E Q+ EK+ + V +L K+A +++ E L+RQ+ + K +L
Sbjct: 1285 HTESGEFSRQLD----EKDAM-------VSQLSRGKQAFTQQIEELKRQLEEETKAKSTL 1333
Query: 962 QEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNA 1021
L++A+ L + +A+ Q A+ E+ + + + + L+ A
Sbjct: 1334 AHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEA 1393
Query: 1022 GEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEG 1081
K L +L++ ++A L+ T+ + ++ + AA + DK+
Sbjct: 1394 K---KKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQ 1450
Query: 1082 -------AALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTK 1134
A ++ E TQ ELE + Q+ L E+ + ++ L L+ L R
Sbjct: 1451 RNFDKVLAEWKQKYEETQAELEAS----QKESRSLSTELFKVKNAYEESLDHLETLKREN 1506
Query: 1135 KYLEERLIEL 1144
K L++ + +L
Sbjct: 1507 KNLQQEISDL 1516
Score = 102 bits (253), Expect = 4e-21
Identities = 140/737 (18%), Positives = 304/737 (41%), Gaps = 75/737 (10%)
Query: 209 LQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVS 268
++ ++ SN + S + + +L +++ +E++ + + +L + L
Sbjct: 1230 MEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESG 1289
Query: 269 QQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEV-TQATQNTVKELQTCLQGLELGAA 327
+ QL + + T + EL++Q E T+A LQ+ +L
Sbjct: 1290 EFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLRE 1349
Query: 328 EKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKG 387
+ EE+ Q EL+ + K N +A + + + D T+
Sbjct: 1350 QYEEE------------QEAKAELQR---GMSKANSEVAQW-----RTKYETDAIQRTEE 1389
Query: 388 RQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLER 447
+E AQ +Q+ E ++A+ + +E+ ++ ++E L+ +++ A +L++
Sbjct: 1390 LEEA-KKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDK 1448
Query: 448 LVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQE 507
+ + E K +E L+ + S EL +++ ++ + E L++E
Sbjct: 1449 KQRNFDKVLAEWKQKYEETQA---ELEASQKESRSLSTELFKVKNAYEESLDHLETLKRE 1505
Query: 508 VRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLE-RLAGPPGPELPV 566
++L +++ L Q+A+ +H+ +LE+ KKQL +K L + E L G L +
Sbjct: 1506 NKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRI 1565
Query: 567 AGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANREL--EKE 624
E N+ V S + + +EE L+ L + + + + E+R N L +K+
Sbjct: 1566 QLELNQ----VKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKK 1621
Query: 625 LQNVVGRNQLLEGKLQALQADYQALQQRESA--IQGSLASLEAEQASIRHLGDQMEASLL 682
++ L E ++Q A+ QA + + QG L + D ++ L
Sbjct: 1622 ME-----GDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLA 1676
Query: 683 AVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRE-------LRALES 735
V + M+A++ E A L+ E + +E+ + + H + + LE+
Sbjct: 1677 MVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLET 1736
Query: 736 QCQQ-QTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQ-----------------AQ 777
Q Q ++ +++ + + +A +A +L Q
Sbjct: 1737 DISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKD 1796
Query: 778 LEVHQGEVQRL-----QAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKE 832
L++ E ++L + Q+ L+A++R + + Q A LR+H+ V++L
Sbjct: 1797 LQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTY 1856
Query: 833 QNE--ALNRAHVQELLQCSEREGALQEERADEAQQREE----ELRALQEELSQAKCSSEE 886
Q E N +Q+L+ + + + +A+EA+++ + R LQ EL +AK ++
Sbjct: 1857 QTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADI 1916
Query: 887 AQLEHAELQEQLHRANT 903
A+ + +L+ + +T
Sbjct: 1917 AESQVNKLRVKSREVHT 1933
Score = 95.9 bits (237), Expect = 3e-19
Identities = 133/627 (21%), Positives = 261/627 (41%), Gaps = 87/627 (13%)
Query: 605 VQEGSQEEELRQANRELEK---ELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLA 661
++ E+E+ E EK EL + + LE K+ L + LQ + A +LA
Sbjct: 844 LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALA 903
Query: 662 SLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQ 721
E + Q+EA + V + E + AE A + E EC +L+++++ +
Sbjct: 904 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 963
Query: 722 LAEARHRELRALESQCQQQT-------QLIEVLTAEKGQQGVGPPTDNEARELAAQLALS 774
+E A E++ + T + I LT EK +A + A Q L
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK-----------KALQEAHQQTLD 1012
Query: 775 QAQLEVHQGEV-----QRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQ 829
Q+E + +L+ QV DL+ +L+ + K+ L A+ L L Q+
Sbjct: 1013 DLQMEEDKVNTLTKAKTKLEQQVDDLE----GSLEQEKKLCMDLERAKRKLEGDLKLAQE 1068
Query: 830 ----LKEQNEALNRAHVQELLQCSEREGALQEER--ADEAQQREEELRA----LQEELSQ 879
+ + LN ++ + S +G +++E+ A + Q++ +EL+A L+EE+
Sbjct: 1069 STMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEA 1128
Query: 880 AKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCA---------------------LTVE 918
+ S +A+ + ++L +L + E G A T++
Sbjct: 1129 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQ 1188
Query: 919 KERVEEAL----ACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGS 974
E AL A +V EL + ++ R ++ LE++ + L+ E L ++ A +
Sbjct: 1189 HEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKAN 1248
Query: 975 LP----GLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRL--KNA------- 1021
L+ QL++ + + + Q+ EL+ K +L E ++ +L K+A
Sbjct: 1249 FEKMCRTLEDQLSEIKTKEEE-QQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSR 1307
Query: 1022 -----GEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLR 1076
++ + L+ QLEE+ + A++ + + E+ AE Q M +
Sbjct: 1308 GKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSK 1367
Query: 1077 KDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKY 1136
+ E A R E + + T +++E KL Q + + E + + + + L +TK+
Sbjct: 1368 ANSEVAQWRTKYE---TDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQR 1424
Query: 1137 LEERLIELLRDKDALWQKSDALEFQQK 1163
L+ + +L+ D + AL+ +Q+
Sbjct: 1425 LQNEVEDLMIDVERSNAACIALDKKQR 1451
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 145 bits (366), Expect = 3e-34
Identities = 204/966 (21%), Positives = 409/966 (42%), Gaps = 141/966 (14%)
Query: 227 EALEGFDEMRLELDQLEVREKQLRERMQQLDRENQEL---RAAVSQQGEQLQTERE---- 279
E E + ++ +L + L+E++Q L++++Q L + + Q QL E+E
Sbjct: 2011 EKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVK 2070
Query: 280 -----RGRTAAEDNVRLT---CLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEE 331
+ R + D +L L A L ++ E +T +E+ +G+E E
Sbjct: 2071 ESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEA 2130
Query: 332 DYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADT----ASDTKG 387
D L E + +E E DSL K ++L L M+++ + A ++K
Sbjct: 2131 DEKKQLHIAEKL-----KERERENDSLKDKVENLERE---LQMSEENQELVILDAENSKA 2182
Query: 388 RQEPIPS---DAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVK----------- 433
E + + + A+ ++ L L E+ + + +++ QL +L K
Sbjct: 2183 EVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE 2242
Query: 434 ----ELQLKEDARASLERLVKEMAPLQE-----------------ELSGKGQEADQLWRR 472
E+Q+KE+++ ++E L ++ L E L +E QL
Sbjct: 2243 KEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNS 2302
Query: 473 LQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDL 532
+++L A + E++ + ++ K+ + +LL+ V +L R+L+ +A+ +Q + L
Sbjct: 2303 IEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELE-----IARTNQEHAAL 2357
Query: 533 EEQKKQLIQDKDHLSQQV-GMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEE 591
E + + + + L ++ GM + L G EL V V + S + + ++E
Sbjct: 2358 EAENSK--GEVETLKAKIEGMTQSLRGL---ELDV--------VTIRSEKENLTNELQKE 2404
Query: 592 QRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQL--LEGKLQALQADYQAL 649
Q + E ++ ++ + QE+E + + + + + QL L ++ AL D +A
Sbjct: 2405 QERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEAC 2464
Query: 650 QQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGEC 709
+ +E + + LE E+A + D+ + + + +LQS
Sbjct: 2465 KAKEQNLSSQVECLELEKAQLLQGLDEAKNNYI------------------VLQSS---V 2503
Query: 710 QQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAA 769
L +EVE +Q E + E+ L++Q Q Q QL+ L+ +G+ + + E R L
Sbjct: 2504 NGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTV 2563
Query: 770 QLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQ 829
+L + ++Q LQ++ LQ + ++++L + + V +
Sbjct: 2564 EL----------EQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNK 2613
Query: 830 LKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQL 889
+ + L R E+ + +++ LQEE + E + EL+ L EE+ +K +E L
Sbjct: 2614 MTAKETELQR----EMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTL 2669
Query: 890 EHAELQEQLHRANTDTAELGIQVCALTVEKE-RVEEALACAVQELQDAKEAASR----ER 944
E++EL++ L + D VEKE +V E +A L +A++
Sbjct: 2670 ENSELKKSLDCMHKD-----------QVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTN 2718
Query: 945 EGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQA-EQRAQSLQEAAHQELNTL 1003
+ E ++ +++ S +E L + K L + +L + + Q L+E +++ L
Sbjct: 2719 KQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNL 2778
Query: 1004 KF--QLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLS 1061
K+ QL E Q ++K + CK L + E ++L + A EK K T M K+
Sbjct: 2779 KYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQK-TGTVMDTKVD 2837
Query: 1062 CTSNHLAECQAAMLRKDKEGAALRE---DLERTQKELEKATTKIQEYYNKLCQEVTNRER 1118
+ + E + + K KE + L + ++LEKA ++ LC + + ++
Sbjct: 2838 ELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDS 2897
Query: 1119 NDQKML 1124
+L
Sbjct: 2898 RGSPLL 2903
Score = 139 bits (349), Expect = 3e-32
Identities = 213/1003 (21%), Positives = 423/1003 (42%), Gaps = 133/1003 (13%)
Query: 233 DEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLT 292
+++R ELD + + L + +++ + QEL S Q E L + E L
Sbjct: 1961 NQLRGELDTMSKKTTALDQLSEKMKEKTQELE---SHQSECLHCIQVAEAEVKEKTELLQ 2017
Query: 293 CLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELE 352
L +++ + + Q ++ L+ Q L L E E L + + +L ++ L+
Sbjct: 2018 TLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQI-AQLNKEKELLVKESESLQ 2076
Query: 353 ATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALER 412
A D + +++ A +K + A QE E+ + + +E+
Sbjct: 2077 ARLSESDYEKLNVSK--ALEAALVEKGEFALRLSSTQE-----------EVHQLRRGIEK 2123
Query: 413 ERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRR 472
R ++E ++Q E+L + + + + +E L +E+ ++S + QE L
Sbjct: 2124 LRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLEREL-----QMSEENQELVIL--D 2176
Query: 473 LQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSD- 531
+ A + + ++ E+ R K + + L E +LT+Q+Q + QL+++ + +S
Sbjct: 2177 AENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSF 2236
Query: 532 ---LEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALV---PVNSSLQEAW 585
LEE+++ IQ K+ V ML+ +L E AL + + +++
Sbjct: 2237 KSLLEEKEQAEIQIKEESKTAVEMLQN-------QLKELNEAVAALCGDQEIMKATEQSL 2289
Query: 586 GKPEEEQRGLQEAQLDDTKVQEGSQEEEL--RQANRELEKELQNVVGRNQLLEGKLQALQ 643
P EE+ L+ + E ++++L Q +E E + GR + LE +L+ +
Sbjct: 2290 DPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIAR 2349
Query: 644 ADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEK----- 698
+ + +G + +L+A+ + +E ++ +R KE + ++ ++
Sbjct: 2350 TNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERIS 2409
Query: 699 ---------EAILQSKEGECQQLRE-----------EVEQCQQLAEARHRELRALESQCQ 738
E ILQ KE E Q++E ++++ + A H + A +++ Q
Sbjct: 2410 ELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQ 2469
Query: 739 QQTQLIEVLTAEKGQ--QGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQ 796
+ +E L EK Q QG+ +N + Q +++ EV G+ Q+L+ + ++
Sbjct: 2470 NLSSQVECLELEKAQLLQGLDEAKNN---YIVLQSSVNGLIQEVEDGK-QKLEKKDEEI- 2524
Query: 797 AKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHV---QELLQCSEREG 853
++++ + DQ+++ S+LS E EH Q KEQN L V Q++ +
Sbjct: 2525 SRLKNQIQDQEQLVSKLSQVEG---EH----QLWKEQNLELRNLTVELEQKIQVLQSKNA 2577
Query: 854 ALQEERADEAQQREEELRALQEELSQAKCSS-------EEAQLEHAELQEQLHRANTDTA 906
+LQ D + + + L+ EL K + + ELQ ++H TA
Sbjct: 2578 SLQ----DTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTA 2633
Query: 907 ELGIQVCALTVEKERVEEALACAVQELQDAKEAASR---EREGLERQVAGLQQEKESLQE 963
EL + L+ EK R+ L ++E++ +K+ E L++ + + +++ +
Sbjct: 2634 ELQEE---LSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEG 2690
Query: 964 KLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGE 1023
K++ + Q +L +AE++ Q+L L+T K Q EI Y+ +L + E
Sbjct: 2691 KVRE------EIAEYQLRLHEAEKKHQALL------LDTNK-QYEVEIQTYREKL-TSKE 2736
Query: 1024 ECKS--------LRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAML 1075
EC S L+ EE L+A + +E+LK T+ D + ++ Q M
Sbjct: 2737 ECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMK 2796
Query: 1076 RKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKK 1135
K L E+ E QKEL + Q +++ M +D+L K
Sbjct: 2797 LLIKSCKQLEEEKEILQKELSQ------------LQAAQEKQKTGTVMDTKVDELTTEIK 2844
Query: 1136 YLEERLIELLRDKDALWQKSDALEFQQKLSAEERWLGDTEANH 1178
L+E L E ++ D K +L + + + + +T+ H
Sbjct: 2845 ELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAH 2887
Score = 130 bits (326), Expect = 1e-29
Identities = 207/997 (20%), Positives = 415/997 (41%), Gaps = 121/997 (12%)
Query: 272 EQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEE 331
E + + R + + +N+RL ++ + ++ E + N +KEL + L E+ K E
Sbjct: 1767 EDIHNLQLRVKETSNENLRLLHVIEDRDRKVE---SLLNEMKELDSKLHLQEVQLMTKIE 1823
Query: 332 ---DYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGR 388
+ + L+ L+++LE + Q + + G + + AD +S
Sbjct: 1824 ACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSS----- 1878
Query: 389 QEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLER- 447
+E I + A+ E+ +E E +++ + L +L++ + + LE+
Sbjct: 1879 REDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKD 1938
Query: 448 ---LVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKE-- 502
K + L+EELS E +QL L + T++ ++ L+E +EK Q+ E +
Sbjct: 1939 NENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQ-LSEKMKEKTQELESHQSE 1997
Query: 503 ------LLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERL 556
+ E EV+ T LQ L + ++++ + + L+E+ + L +D LS LE
Sbjct: 1998 CLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELEN- 2056
Query: 557 AGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEG-------S 609
++ ++ E LV + SLQ + + E+ + +A L+ V++G S
Sbjct: 2057 ------QIAQLNKEKELLVKESESLQARLSESDYEKLNVSKA-LEAALVEKGEFALRLSS 2109
Query: 610 QEEELRQANRELEK-----------------ELQNVVGRNQLLEGKLQALQADYQALQQR 652
+EE+ Q R +EK +L+ N L+ K++ L+ + Q ++
Sbjct: 2110 TQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEEN 2169
Query: 653 ESAI----QGSLASLEAEQASIRHLGDQM---EASLLAVRKAKEAMKAQMAEKEAILQSK 705
+ + + S A +E + I + + E L+ +R KE + Q+ EK+ L
Sbjct: 2170 QELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSEL 2229
Query: 706 E---GECQQLREEVEQCQ-QLAEARHRELRALESQCQQQTQLIEVLTAEK-----GQQGV 756
+ + L EE EQ + Q+ E + L++Q ++ + + L ++ +Q +
Sbjct: 2230 DKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSL 2289
Query: 757 GPPTD------NEARELAAQLALSQ-------AQLEVHQGEVQRLQAQVVDLQAKMRAAL 803
PP + N +L A+L + QL+ + L+ +V +L+ ++ A
Sbjct: 2290 DPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIAR 2349
Query: 804 DDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEA 863
+Q+ + AE E +TL +++ ++L + + SE+E E + ++
Sbjct: 2350 TNQEHAALE---AENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQE 2406
Query: 864 QQREEEL------RALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTV 917
+ E E+ LQE+ + E++ LQ QL N A L A
Sbjct: 2407 RISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKA 2466
Query: 918 EKERVEEALACAVQE---LQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGS 974
+++ + + C E L + A L+ V GL QE E ++KL+
Sbjct: 2467 KEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDE---E 2523
Query: 975 LPGLQAQLAQAEQRAQSLQ--EAAHQ-------ELNTLKFQLSAEIMDYQSR-------L 1018
+ L+ Q+ EQ L E HQ EL L +L +I QS+ L
Sbjct: 2524 ISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTL 2583
Query: 1019 KNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAML--- 1075
+ K+L +LE + E V K+ A + ++ ++ + AE Q +
Sbjct: 2584 EVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEK 2643
Query: 1076 -RKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTK 1134
R E L E+++ ++ +L++ T + E L ++ + K+ ++ +
Sbjct: 2644 NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRL 2703
Query: 1135 KYLEERLIELLRDKDALWQKSDALEFQQKLSAEERWL 1171
E++ LL D + ++ + +++KL+++E L
Sbjct: 2704 HEAEKKHQALLLDTNKQYE-VEIQTYREKLTSKEECL 2739
Score = 104 bits (259), Expect = 7e-22
Identities = 255/1266 (20%), Positives = 487/1266 (38%), Gaps = 197/1266 (15%)
Query: 14 IRDLQDAVTELSKEFQEAGEPITDDSTSLHKFSYKLEYLLQFDQKEKATLLGNKKDYWDY 73
I++L+ + +L KE Q+ + +L K K+E ++K + T L +
Sbjct: 20 IQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVE-----NEKTEGTNLKRENQRLME 74
Query: 74 FCACLAKVKGA--------NDGIRFV--------KSISELRTSLGKGRAFIRYSLVHQRL 117
C L K K + F K I +L L + ++ + S +
Sbjct: 75 ICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQS 134
Query: 118 AD-TLQQC-----FMNTKVTSDWYYARSPF--LQPKLSSDIVGQLYELTEVQFDLASRGF 169
AD +L C T +T YY+ S + L+ K + ++ + EV+ L ++
Sbjct: 135 ADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKA-LQAKKA 193
Query: 170 DLDAAWPTFARRTLT---TGSSAYLW---KPPSRSSSMSSLV-------SSYLQTQEMV- 215
T R + SS + W K PS SS S +SY ++ V
Sbjct: 194 SQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVT 253
Query: 216 ---SNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQ----ELRAAVS 268
S + N + LDQL+ + ++LR ++ +L+ Q E++ V+
Sbjct: 254 PSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVN 313
Query: 269 QQGE-QLQTER-----------------ERGRTAAEDNVRLTCLVAELQKQWEVTQATQN 310
+ E QLQ E+ E RT A+ + T A QK ++T+
Sbjct: 314 KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSC 373
Query: 311 TVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPG 370
+ ++ LE EKE+++ L R + Q L QE + L ++ Q +
Sbjct: 374 QRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN 433
Query: 371 WLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQA-------LERERTKVEEVNRQ 423
L Q + D + K + E + Q++ + QA L R ++++ N
Sbjct: 434 VL---QAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNL 490
Query: 424 QSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELL---AHT 480
+ EQ +E+ E ++++ + + EE+ K + + R LQE + ++
Sbjct: 491 LKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENS 550
Query: 481 SSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLI 540
+ E+ + +KQ+ ++LL++ E + Q++ +S E++ K L+
Sbjct: 551 LTLEKLKLAVADLEKQRDCSQDLLKKR-----------EHHIEQLNDKLSKTEKESKALL 599
Query: 541 QDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQL 600
+ ++ E L E + L + S + K + L+ Q+
Sbjct: 600 SALELKKKE---YEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQI 656
Query: 601 DDTKVQEGSQEEELRQANRELE-KELQNVVGRNQLLEGKLQALQADYQALQQR-ESAIQG 658
+ E + E+ + N +E + L NV+ + +++ + Y LQQ+ E + Q
Sbjct: 657 KSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSV---EVETQKLAYMELQQKAEFSDQK 713
Query: 659 SLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQ 718
+E L Q+E + + + ++ +K+ Q E + LR+ ++
Sbjct: 714 HQKEIENMCLKTSQLTGQVE----DLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKS 769
Query: 719 CQQ---LAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQ 775
E R L A + Q ++ G+QG P +E R A Q +
Sbjct: 770 KDASLVTNEDHQRSLLAFDQQPAMHHSFANII----GEQGSMPSERSECRLEADQSPKNS 825
Query: 776 AQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNE 835
A L Q V L+ ++SQ M + ++ + LVQ E E
Sbjct: 826 AIL---QNRVDSLEF-----------------SLESQKQMNSDLQKQCEELVQIKGEIEE 865
Query: 836 ALNRA---HVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHA 892
L +A H + + S+R LQE+ + E L AL+ + + + +++ + E A
Sbjct: 866 NLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQA 925
Query: 893 ELQE---QLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLER 949
E+QE H EL + L++EK+ + ++ +E+ E ++E L+
Sbjct: 926 EIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREI----EELTQENGTLKE 981
Query: 950 QVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSA 1009
A L QEK +L +K +++ A + ++R +S+ E + Q
Sbjct: 982 INASLNQEKMNLIQK---SESFANYI----------DEREKSISELSDQ----------- 1017
Query: 1010 EIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAE 1069
Y+ + C+ E+ ++ +AA+E KL+ + N L +
Sbjct: 1018 ----YKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQ 1073
Query: 1070 CQAAMLRKDKE-----------GAALREDLERTQKELEKATTKIQEYYNK----LCQEVT 1114
+ A ++ +E L +LE Q+ L T Q L QE+
Sbjct: 1074 LKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIM 1133
Query: 1115 NRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQ-KLSAEERWLGD 1173
+ KM +++DL + E+L+++++ K + LE + + S +ER +
Sbjct: 1134 TLKEEQNKMQKEVNDLLQE----NEQLMKVMKTK----HECQNLESEPIRNSVKER---E 1182
Query: 1174 TEANHC 1179
+E N C
Sbjct: 1183 SERNQC 1188
Score = 103 bits (258), Expect = 9e-22
Identities = 185/896 (20%), Positives = 344/896 (38%), Gaps = 143/896 (15%)
Query: 240 DQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQ 299
D L+ RE + + +L + +E +A +S L+ +++ E+ +C +E +
Sbjct: 572 DLLKKREHHIEQLNDKLSKTEKESKALLSA----LELKKKEYEELKEEKTLFSCWKSENE 627
Query: 300 K---QWEVTQAT-QNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATR 355
K Q E + Q+ + L+TCL+ ++ K +Y+ +R LE + L+ E+
Sbjct: 628 KLLTQMESEKENLQSKINHLETCLKTQQI----KSHEYNERVRTLEMDRENLSVEIRNLH 683
Query: 356 DSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPI-----PSDAAQEMQELGEKLQAL 410
+ LD K+ + + QQKA+ SD K ++E S ++++L KLQ L
Sbjct: 684 NVLDSKSVEVETQKLAYMELQQKAEF-SDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLL 742
Query: 411 ERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLW 470
E + + A+ E L L+ K+ + + E + + ++ + +
Sbjct: 743 SNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPA--------MH 794
Query: 471 RRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVS 530
++ S E +E R E Q + +L+ V SL E L Q S
Sbjct: 795 HSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSL-------EFSLESQKQMNS 847
Query: 531 DLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEE 590
DL++Q ++L+Q K GE E L+ Q + +
Sbjct: 848 DLQKQCEELVQIK------------------------GEIEENLMKAEQMHQSFVAETSQ 883
Query: 591 EQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQ 650
LQE DT + E L A EKELQ LL K++ QA+ Q L+
Sbjct: 884 RISKLQE----DTSAHQNVVAETL-SALENKEKELQ-------LLNDKVETEQAEIQELK 931
Query: 651 QRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQ 710
+ ++ SL L+ ++ +M + + ++ E + + + I S E
Sbjct: 932 KSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKM 991
Query: 711 QLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQ 770
L ++ E + R + + L Q +Q+ ++ E G
Sbjct: 992 NLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGN----------------- 1034
Query: 771 LALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQL 830
DL K +AA + K++ L+ ++ K ++QL
Sbjct: 1035 --------------------AYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQL 1074
Query: 831 KEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEEL-SQAKCSSEEAQL 889
K EA + H + L + A EER Q EL +Q+ L S+ + ++
Sbjct: 1075 K---EAFAKEHQEFLTKL-----AFAEER---NQNLMLELETVQQALRSEMTDNQNNSKS 1123
Query: 890 EHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLER 949
E L++++ + ++ +V L E E++ ++ ++ E + E E +
Sbjct: 1124 EAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQL-------MKVMKTKHECQNLESEPIRN 1176
Query: 950 QVAGLQQEKESLQEKLKA-AKAAAGSLPGLQAQLAQAE----------QRAQSLQEAAHQ 998
V + E+ K + + SL AQL Q E Q ++ +E
Sbjct: 1177 SVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQH 1236
Query: 999 ELNTLKFQL-SAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMG 1057
EL T++ L ++ + D QS+ + ++C +++ + + + E + + A +
Sbjct: 1237 ELQTIRGDLETSNLQDMQSQEISGLKDC-----EIDAEEKYISGPHE-LSTSQNDNAHLQ 1290
Query: 1058 EKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEV 1113
L T N L E + E L +L ++ E AT K+ E KL EV
Sbjct: 1291 CSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEV 1346
Score = 97.8 bits (242), Expect = 7e-20
Identities = 239/1173 (20%), Positives = 459/1173 (39%), Gaps = 248/1173 (21%)
Query: 201 MSSLVSSYLQ-----TQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQ 255
MSS++S + TQE + ++N+ LN E + + + ++ REK + E Q
Sbjct: 958 MSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQ 1017
Query: 256 LDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKEL 315
+E L + G + ++ + A E N +L CL+ E T +N EL
Sbjct: 1018 YKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLN------ECTSLCENRKNEL 1071
Query: 316 QTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSL-----DKKNQHLASFPG 370
+ L+ A++ +++ T L E Q L ELE + +L D +N + G
Sbjct: 1072 EQ----LKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGG 1127
Query: 371 WLAMAQQKADTASDTKGRQEPIPSDAAQEMQEL------GEKLQALE----RERTKVEEV 420
+Q+ T + + + + +D QE ++L + Q LE R K E
Sbjct: 1128 ----LKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERES 1183
Query: 421 NRQQ---SAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELL 477
R Q Q++ VKE+ L + A L +L + + +L +E + L LQ +
Sbjct: 1184 ERNQCNFKPQMDLEVKEISL-DSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIR 1242
Query: 478 A--HTSSWE----EELAELR--------------REKKQQQEEKELLEQEVRSLTRQLQF 517
TS+ + +E++ L+ E Q + L+ +++ +L
Sbjct: 1243 GDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNE 1302
Query: 518 LE--TQLAQVSQH--VSDLEEQKKQLIQDKDHLSQQVGML----------------ERLA 557
LE ++ Q ++ V++L + + + I ++++VG L E +
Sbjct: 1303 LEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVE 1362
Query: 558 GPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQE---------- 607
PG E GE+ PV+ + + E +E Q+ ++QE
Sbjct: 1363 DIPGGEF---GEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHK 1419
Query: 608 --GSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADY---QALQQRESAIQGSLAS 662
Q ++ EL+ + ++ N +L L+ Q D L E + +S
Sbjct: 1420 ILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSS 1479
Query: 663 LEAEQASIRHLGD------------------QMEASLLAVRKAKEAMKAQMAEKEAI--- 701
+ +S+ LGD +E ++ A + + + + ++E +
Sbjct: 1480 CVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRK 1539
Query: 702 ---------LQSKEGECQQLREEVEQCQQLAEA----RHRELRALESQCQQQTQLIEVLT 748
++ E C+ R+ +E+ ++ E+ +++E++ LE + Q ++ L
Sbjct: 1540 ETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLR 1599
Query: 749 A------EKGQQGVGPPT-DNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRA 801
E+ QQ + T + E++ A + Q LE+ EV RLQ Q +DL ++
Sbjct: 1600 KQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLEL---EVARLQLQGLDLSSRSLL 1656
Query: 802 ALDDQDKVQ--------SQLSMAEAVLREHKTLVQQL--KEQNEALNRAHVQELLQCS-- 849
+D +D +Q S+ +E R K V Q+ K+ + LN ++++ +
Sbjct: 1657 GIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLN-LDIEKITETGAV 1715
Query: 850 EREGALQEERADEAQQR---EEELRALQEELSQAKCSSEEA--QLEHAELQEQLHRAN-- 902
+ G E++ + E++ + E +S+ S A ++ QE +H
Sbjct: 1716 KPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLR 1775
Query: 903 -TDTAELGIQVCALTVEKERVEEALACAVQE------LQDAKEAASRER-EGLERQVAGL 954
+T+ +++ + +++R E+L ++E LQ+ + E LE+ V L
Sbjct: 1776 VKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGEL 1835
Query: 955 QQEKESLQEKL-----------------------------KAAKAAAG------------ 973
++E L EKL K+++ G
Sbjct: 1836 KKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKE 1895
Query: 974 -------SLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAE-------IMDYQSRLK 1019
L ++++ A E A L EA + + T K L + I+ + L
Sbjct: 1896 RFLDVENELSRIRSEKASIEHEALYL-EADLEVVQTEKLCLEKDNENKQKVIVCLEEELS 1954
Query: 1020 NAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKD- 1078
E LRG+L+ ++ A ++ EK+K EK +H +EC + +
Sbjct: 1955 VVTSERNQLRGELDTMSKKTTALDQLSEKMK-------EKTQELESHQSECLHCIQVAEA 2007
Query: 1079 --KEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKY 1136
KE L + L EL K T +QE KL Q + D L+ TK
Sbjct: 2008 EVKEKTELLQTLSSDVSELLKDKTHLQE---KL-----------QSLEKDSQALSLTKCE 2053
Query: 1137 LEERLIELLRDKDALWQKSDALEFQQKLSAEER 1169
LE ++ +L ++K+ L ++S++L+ + S E+
Sbjct: 2054 LENQIAQLNKEKELLVKESESLQARLSESDYEK 2086
Score = 82.4 bits (202), Expect = 3e-15
Identities = 157/775 (20%), Positives = 318/775 (41%), Gaps = 111/775 (14%)
Query: 433 KELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRR 492
+ LQ ++ L++L KE Q +L D L LQ+ + + E L+R
Sbjct: 15 RALQKIQELEGQLDKLKKEKQQRQFQL-------DSLEAALQKQKQKVENEKTEGTNLKR 67
Query: 493 EKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGM 552
E ++ E E LE+ + ++ +LQ E +QV+ L KKQ+ + + L +
Sbjct: 68 ENQRLMEICESLEKTKQKISHELQVKE---SQVNFQEGQLNSGKKQIEKLEQELKRCKSE 124
Query: 553 LERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEE 612
LER A + +L P N+ Q+ + P L ++ GS+ E
Sbjct: 125 LER-------SQQAAQSADVSLNPCNTP-QKIFTTP-----------LTPSQYYSGSKYE 165
Query: 613 ELRQA-NRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIR 671
+L++ N+E+E+ + L+A+ +ALQ ++ AS QA++
Sbjct: 166 DLKEKYNKEVEER---------------KRLEAEVKALQAKK-------ASQTLPQATMN 203
Query: 672 H---LGDQMEASLLAVRKAK-EAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARH 727
H Q +S+ + ++ K + + +++ I + +EV + +
Sbjct: 204 HRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGK 263
Query: 728 RELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQR 787
R+ + L++ L A+ + N+ EL +L + +++ + Q
Sbjct: 264 RDANSSFFDNSSSPHLLDQLKAQNQE------LRNKINELELRLQGHEKEMKGQVNKFQE 317
Query: 788 LQAQV----VDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQ 843
LQ Q+ V+L K + +D++ + + ++ L Q+LK+ E L+
Sbjct: 318 LQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLS----- 372
Query: 844 ELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLE----HAELQEQLH 899
+R+ A + R Q+ +E+ + QEELS+ + S + E A L ++L
Sbjct: 373 -----CQRQNA-ESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQ 426
Query: 900 RANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEA--ASREREG-LERQVAGLQQ 956
+A L ++ LT K+++E L Q+L A++A AS+ +E L R + +++
Sbjct: 427 QAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKK 486
Query: 957 EKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQS 1016
E L+ ++ A + L+A+L +Q Q A +E+ + D Q
Sbjct: 487 ENNLLKSH---SEQKAREVCHLEAELKNIKQCLNQSQNFA-EEMKAKNTSQETMLRDLQE 542
Query: 1017 RLKNAGEE--CKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAM 1074
++ + L+ + + +Q +++ ++K + + +KLS T +A+
Sbjct: 543 KINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSAL 602
Query: 1075 LRKDKEGAALREDL----------ERTQKELEKATTKIQEYYNKL-----CQEVTNRERN 1119
K KE L+E+ E+ ++E +Q N L Q++ + E N
Sbjct: 603 ELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYN 662
Query: 1120 DQKMLADLD------DLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEE 1168
++ ++D ++ L+ + +E+ K A + EF + +E
Sbjct: 663 ERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKE 717
Score = 80.9 bits (198), Expect = 9e-15
Identities = 166/825 (20%), Positives = 335/825 (40%), Gaps = 124/825 (15%)
Query: 389 QEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERL 448
+E +P+ A Q++QEL QL++L KE Q ++ SLE
Sbjct: 9 KEGLPTRALQKIQEL---------------------EGQLDKLKKEKQQRQFQLDSLEAA 47
Query: 449 VKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEV 508
+++ ++++ + E L R Q L+ S E+ ++ E + ++ + E ++
Sbjct: 48 LQKQ---KQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQL 104
Query: 509 RSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERL-AGPPGPELPVA 567
S +Q++ LE +L + + E+ +Q Q D +++ P P +
Sbjct: 105 NSGKKQIEKLEQELKRCKSEL----ERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYS 160
Query: 568 GEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEEL--RQANRELEKEL 625
G K E L + E + E E + LQ + T Q ++ QA+ +
Sbjct: 161 GSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQ 220
Query: 626 QNVVGRNQLLEGKLQALQADYQALQ-QRESAIQGSLASLEA----------EQASIRHLG 674
Q + + ++ D+ A E + S ++L+ + +S HL
Sbjct: 221 QEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLL 280
Query: 675 DQMEASLLAVRK----------------------------AKEAMKAQMAEKEAILQSKE 706
DQ++A +R E K ++ EKE +L
Sbjct: 281 DQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCR 340
Query: 707 GECQQLREEVEQCQQLAEARHRELRAL--ESQCQQQTQLIEVLTAEKGQQGVGPPTDNEA 764
E + + +Q A ++L+ L + CQ+Q AE + + +
Sbjct: 341 DELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQ-------NAESARCSLEQKIKEKE 393
Query: 765 RELAAQLALSQAQLEVHQGEVQRLQAQVVD--LQAK-----MRAALDDQDKVQSQLSMAE 817
+E +L+ Q + E +++A++ QAK ++A LD V+ QL E
Sbjct: 394 KEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQL---E 450
Query: 818 AVLREHKTLVQQLKEQNEALNRAHVQE-----LLQCSEREGAL----QEERADEAQQREE 868
L E K Q+L +A + ++E ++ ++E L E++A E E
Sbjct: 451 NNLEEFK---QKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEA 507
Query: 869 ELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALAC 928
EL+ +++ L+Q++ +EE + ++ + L ++ Q +LT+EK L
Sbjct: 508 ELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQ---EKINQQENSLTLEK------LKL 558
Query: 929 AVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQR 988
AV +L+ ++ + ++ L+++ ++Q + L + K +KA +L L+ + + +
Sbjct: 559 AVADLEKQRDCS---QDLLKKREHHIEQLNDKLSKTEKESKALLSALE-LKKKEYEELKE 614
Query: 989 AQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEK 1048
++L E L Q+ +E + QS++ + K+ + + E +++ E E
Sbjct: 615 EKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDREN 674
Query: 1049 LKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNK 1108
L ++ L S + E Q + ++ A + ++ QKE+E K ++
Sbjct: 675 LSVEIRNLHNVLDSKSVEV-ETQKLAYMELQQKAEFSD--QKHQKEIENMCLKT----SQ 727
Query: 1109 LCQEVTNRERNDQKMLADLDDLNRTKKYLE---ERLIELLRDKDA 1150
L +V + E Q + ++ D +R + L E L +LL+ KDA
Sbjct: 728 LTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDA 772
Score = 77.0 bits (188), Expect = 1e-13
Identities = 181/888 (20%), Positives = 362/888 (40%), Gaps = 160/888 (18%)
Query: 234 EMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTC 293
+++ + ++L + ++ E + + ++ +Q A SQ+ +LQ + T+A NV
Sbjct: 848 DLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQED-----TSAHQNV---- 898
Query: 294 LVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEA 353
VAE A +N KELQ +E AE +E L++ +L+ +EL+
Sbjct: 899 -VAE------TLSALENKEKELQLLNDKVETEQAEIQE-----LKKSNHLLEDSLKELQL 946
Query: 354 TRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQAL--- 410
++L + + ++S +++ +++ + + G + I + QE L +K ++
Sbjct: 947 LSETLSLEKKEMSSI---ISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANY 1003
Query: 411 --ERERTKVEEVNRQQSAQL-------------EQLVKELQLKEDARASLERLVKEMAPL 455
ERE++ E ++ + +L E L ++ + ++ + LE L+ E L
Sbjct: 1004 IDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSL 1063
Query: 456 QEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQE---EKELLEQEVRS-L 511
E + E +QL A +E L +L +++ Q E E ++Q +RS +
Sbjct: 1064 CEN---RKNELEQLKE------AFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEM 1114
Query: 512 TRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKN 571
T +++ + Q + L+E++ ++ ++ + L Q+ L ++ + E
Sbjct: 1115 TDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPI 1174
Query: 572 EALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGR 631
V S + + ++E LD Q E LR N+EL+ LQ
Sbjct: 1175 RNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLR--NKELK--LQESEKE 1230
Query: 632 NQLLEGKLQALQADYQA--LQQRESAIQGSL--ASLEAEQASIR-------------HLG 674
+ L+ +LQ ++ D + LQ +S L ++AE+ I HL
Sbjct: 1231 KECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQ 1290
Query: 675 DQMEASLLAVRKAKEAMKAQMAEKEAI---LQSKEGEC----QQLREEVEQCQQLAEARH 727
++ ++ + + ++ + AEK + L EC +++ EEV + + +
Sbjct: 1291 CSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILN 1350
Query: 728 RELRALESQCQQQTQLIEVLTAEKGQQ-------GVGPPTDNEARELAAQLALSQAQLEV 780
+ L + + ++ E G+Q + P ++ + E L LS ++++
Sbjct: 1351 DDSGLLHGELVE-----DIPGGEFGEQPNEQHPVSLAPLDESNSYE---HLTLSDKEVQM 1402
Query: 781 HQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALN-- 838
H E LQ + + LQ++ + D ++ S++S E +T V LK +N L+
Sbjct: 1403 HFAE---LQEKFLSLQSEHKILHDQHCQMSSKMS-------ELQTYVDSLKAENLVLSTN 1452
Query: 839 ----RAHVQELLQCSEREG--------------------------ALQEERADEAQQREE 868
+ + + +Q EG AL E+ D +
Sbjct: 1453 LRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSL---- 1508
Query: 869 ELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTA--------ELGIQVCALTVEK- 919
L L+ +S +CS +E + +E L R T +A E +V ++EK
Sbjct: 1509 -LSNLEGAVSANQCSVDEVFCSSLQ-EENLTRKETPSAPAKGVEELESLCEVYRQSLEKL 1566
Query: 920 -ERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGL 978
E++E +E+Q+ ++ S ER+ L+ E E Q+KL + S L
Sbjct: 1567 EEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMES--KL 1624
Query: 979 QAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEI-MDYQSRLKNAGEEC 1025
A+ Q EQ + L E A +L L + + +D + ++ E C
Sbjct: 1625 AAEKKQTEQLSLEL-EVARLQLQGLDLSSRSLLGIDTEDAIQGRNESC 1671
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 144 bits (364), Expect = 5e-34
Identities = 190/869 (21%), Positives = 362/869 (41%), Gaps = 136/869 (15%)
Query: 394 SDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKE---LQLK--------EDAR 442
++ +EM + E+ Q + E K E ++ ++ L+KE LQL+ DA
Sbjct: 846 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAE 905
Query: 443 ASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRRE-------KK 495
E+L+K L+ ++ + A++ EL A E+E +EL+++
Sbjct: 906 ERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 965
Query: 496 QQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLER 555
+ ++EK E +V++LT ++ L+ +A++S+ L+E +Q + D +V +L +
Sbjct: 966 KVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTK 1025
Query: 556 LAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELR 615
++ E + L+ A K E + + QE+ +D E + +
Sbjct: 1026 AKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMD--------MENDKQ 1077
Query: 616 QANRELEK---ELQNVVGRNQ-------LLEGKLQALQADYQALQQRESAIQGSLASLEA 665
Q + +LEK E+ N++ + + L+ K++ LQA + L + A + S A E
Sbjct: 1078 QLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEK 1137
Query: 666 EQASIR---------------------HLGDQMEASLLAVRKAKEAMKAQMAEKEAILQS 704
+++ + L + EA +R+ E Q A L+
Sbjct: 1138 QRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRK 1197
Query: 705 KEGECQ-QLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNE 763
K + +L E+++ Q++ + +E L+ + + E ++ KG +
Sbjct: 1198 KHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGN------LEKM 1251
Query: 764 ARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQ---AKMRAALDDQDKVQSQLSMA-EAV 819
R L Q++ + + E Q + L AQ LQ + LD++D + SQLS + +A
Sbjct: 1252 CRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAS 1311
Query: 820 LREHKTLVQQLKEQNEALNR-AHVQELLQCSEREGALQEERADEAQQREEELRALQEELS 878
++ + L QL+E+ +A N AH ALQ R D RE+
Sbjct: 1312 TQQIEELKHQLEEETKAKNALAH------------ALQSSRHDCDLLREQ---------- 1349
Query: 879 QAKCSSEEAQLEHAELQEQLHRANTDTAE----LGIQVCALTVEKERVEEALACAVQELQ 934
EE Q AELQ L +AN++ A+ T E E ++ LA +QE +
Sbjct: 1350 -----YEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1404
Query: 935 DAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQ-------AQLAQAEQ 987
+ EA + + LE+ LQ E E L ++ + AA +L Q ++ Q +
Sbjct: 1405 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYE 1464
Query: 988 RAQSLQEAAHQELNTLKFQLSAEIMDYQSRL----------KNAGEECKSLRGQLEEQGR 1037
Q+ EA+ +E +L +L Y+ L KN +E L Q+ E G+
Sbjct: 1465 ETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGK 1524
Query: 1038 QLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEK 1097
Q+ E+ ++++ + ++ L L + +LR E ++ +++R E ++
Sbjct: 1525 QIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDE 1584
Query: 1098 ATTKIQEYYNKLCQEVTN------RERND-----QKMLADLDDLNRTKKYLEERLIELLR 1146
+++ + ++ + + + R RND +KM DL+++ + E LR
Sbjct: 1585 EIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLR 1644
Query: 1147 D--------KDALWQKSDALEFQQKLSAE 1167
+ K+ DAL Q+ L +
Sbjct: 1645 NYRNTQGILKETQLHLDDALRGQEDLKEQ 1673
Score = 144 bits (363), Expect = 6e-34
Identities = 210/1021 (20%), Positives = 420/1021 (41%), Gaps = 122/1021 (11%)
Query: 230 EGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNV 289
E F + + EL + E + K+L E+M L +E +L+ V + + L ER ++ +
Sbjct: 857 EEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKI 916
Query: 290 RLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQ 349
+L + E+ ++ E + EL + LE +E ++D + LE L + +
Sbjct: 917 QLEAKIKEVTERAEEEEEIN---AELTAKKRKLEDECSELKKD----IDDLELTLAKVEK 969
Query: 350 ELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQA 409
E AT + + + +A +A ++ +T Q+ + A+E +K+
Sbjct: 970 EKHATENKVKNLTEEMAGLDETIAKLSKEKKALQET--HQQTLDDLQAEE-----DKVNI 1022
Query: 410 LERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQL 469
L + +TK+E+ LEQ E +L+ D + +L ++ QE + QL
Sbjct: 1023 LTKAKTKLEQQVDDLEGSLEQ---EKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQL 1079
Query: 470 WRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHV 529
+L++ E E++ L + + +Q + L+++++ L +++ L ++
Sbjct: 1080 DEKLEKK-------EFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASR 1132
Query: 530 SDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPE 589
+ E+Q+ L ++ + +S++ LE G ++ + ++ + L+EA + E
Sbjct: 1133 AKAEKQRSDLSRELEEISER---LEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHE 1189
Query: 590 EEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQAL 649
L++ D+ + G Q + L++ ++LEKE + L +A+ L
Sbjct: 1190 AMVAALRKKHA-DSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNL 1248
Query: 650 QQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAIL----QSK 705
++ +++ ++ L+ ++ + L + + A ++ Q+ EK+A++ +SK
Sbjct: 1249 EKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSK 1308
Query: 706 EGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEAR 765
+ QQ+ E Q ++ +A++ AL+S L E E+ Q+G
Sbjct: 1309 QASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLRE--QYEEEQEG---------- 1356
Query: 766 ELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKT 825
+ Q ALS+A EV Q + + + ++ A + K+ +L AE +
Sbjct: 1357 KAELQRALSKANSEVAQWRT-KYETDAIQRTEELEEA---KKKLAQRLQEAEEHVEAVNA 1412
Query: 826 LVQQLKEQNEALNRAHVQELLQCSEREGAL---------------------QEERADEAQ 864
L++ + L V++L+ ER A EE E +
Sbjct: 1413 KCASLEKTKQRLQN-EVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELE 1471
Query: 865 QREEELRALQEELSQAKCSSEEA-------QLEHAELQEQLHRANTDTAELGIQVCALTV 917
++E R+L EL + K EE+ + E+ LQ+++ AE G Q+ L
Sbjct: 1472 ASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEK 1531
Query: 918 EKERVEEALACAVQELQDAKEAASREREG-LERQVAGLQQEKESLQEKLKAAKAAAGSLP 976
K++VE+ C +Q + EA+ EG + R L Q K + K+ L
Sbjct: 1532 IKKQVEQE-KCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK 1590
Query: 977 GLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGE-ECKSLR------ 1029
++ + Q + + + +K ++ ++ + + +L +A +SLR
Sbjct: 1591 RNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQ 1650
Query: 1030 GQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDL- 1088
G L+E L A E LK A + + + + E A + + ++ ++L
Sbjct: 1651 GILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELL 1710
Query: 1089 ---ER-------------TQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADL----- 1127
ER T+K+LE +++Q ++ QE N E +K + D
Sbjct: 1711 DASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAE 1770
Query: 1128 ---------DDLNRTKKYLEERLIEL---LRDKDALWQKSDALEFQQKLSAEERWL-GDT 1174
L R KK LE+ + +L L + + L K + QKL A R L G+
Sbjct: 1771 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQI-QKLEARVRELEGEV 1829
Query: 1175 E 1175
E
Sbjct: 1830 E 1830
Score = 140 bits (354), Expect = 7e-33
Identities = 212/999 (21%), Positives = 405/999 (40%), Gaps = 177/999 (17%)
Query: 226 NEALEGFDEMRLELDQLEVRE-------KQLRERMQQLD-------RENQELRAAVSQQG 271
+E + D++ L L ++E + K L E M LD +E + L+ Q
Sbjct: 951 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTL 1010
Query: 272 EQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEE 331
+ LQ E ++ + +L V +L+ E + + ++ + L+G A E
Sbjct: 1011 DDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTM 1070
Query: 332 DYHTALRRLESMLQPLAQEL----------EATRDSLDKKNQHLASFPGWLAMAQQKADT 381
D ++L+ L+ E+ +A L KK + L + L + +A+
Sbjct: 1071 DMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELG-EEIEAER 1129
Query: 382 ASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDA 441
AS K ++ SD ++E++E+ E+L+ + E+N+++ A+ ++L ++L E+A
Sbjct: 1130 ASRAKAEKQR--SDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDL---EEA 1184
Query: 442 RASLERLVKEMAPLQ-EELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEE 500
E +V + + ++ G++ D L R Q+L S + E +L + +
Sbjct: 1185 TLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKA 1244
Query: 501 KELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPP 560
K LE+ RSL Q+ L+T+ + + ++DL Q+ +L + S+Q+ + L
Sbjct: 1245 KGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQL 1304
Query: 561 GPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEE------- 613
+ ++ E L L+E LQ ++ D ++E +EE+
Sbjct: 1305 SRSKQASTQQIEEL---KHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQ 1361
Query: 614 --LRQANRELE----KELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQ 667
L +AN E+ K + + R + LE + L Q ++ A+ ASLE +
Sbjct: 1362 RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTK 1421
Query: 668 ASIRHLGDQMEASLLAVRKAKEAM-----------------KAQMAEKEAILQSKEGECQ 710
+ L +++E +L V ++ A K + E +A L++ + E +
Sbjct: 1422 ---QRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESR 1478
Query: 711 QLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLT---AEKGQQ-----GVGPPTDN 762
L E+ + + + E +L L + + Q I LT AE G+Q + +
Sbjct: 1479 SLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQ 1538
Query: 763 EARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLRE 822
E E+ A L ++A LE +G++ R+Q ++ +++++ + ++D+ QL + E
Sbjct: 1539 EKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVE 1598
Query: 823 --HKTLVQQLKEQNEAL--------------------NRAHVQELLQCSEREGALQE--- 857
TL +++ +N+AL NR + L +G L+E
Sbjct: 1599 TMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQL 1658
Query: 858 --------------------ERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQ 897
RA+ Q EEL A E+ +++ +E+ L+ +E +
Sbjct: 1659 HLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQL 1718
Query: 898 LHRANT-----------DTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREG 946
LH NT D ++L +V + E EE A+ + E +E++
Sbjct: 1719 LHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDT 1778
Query: 947 ---LERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQEL--- 1000
LER L+Q + LQ +L A+ A L G + Q+ + E R + L+ E
Sbjct: 1779 SAHLERMKKNLEQTVKDLQHRLDEAEQLA--LKGGKKQIQKLEARVRELEGEVENEQKRN 1836
Query: 1001 --------------------------NTLKFQ-----LSAEIMDYQSRLKNAGEEC---- 1025
N L+ Q L A++ Y+ + + A E+
Sbjct: 1837 AEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANL 1896
Query: 1026 ---KSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLS 1061
+ L+ +LEE + AE V KL+ ++ K+S
Sbjct: 1897 SKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKIS 1935
Score = 60.8 bits (146), Expect = 9e-09
Identities = 68/338 (20%), Positives = 142/338 (42%), Gaps = 50/338 (14%)
Query: 862 EAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQV--------- 912
++ + E+E+ ++EE + K +++ + EL+E++ + +L +QV
Sbjct: 844 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLAD 903
Query: 913 ----CALTV------------------EKERVEEALACAVQELQDAKEAASREREGLERQ 950
C + E+E + L ++L+D ++ + LE
Sbjct: 904 AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELT 963
Query: 951 VAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAE 1010
+A +++EK + + K+ K + GL +A+ + ++LQE Q L+ L Q +
Sbjct: 964 LAKVEKEKHATENKV---KNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDL--QAEED 1018
Query: 1011 IMDYQSRLKNAGE-ECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAE 1069
++ ++ K E + L G LE++ + E A KL+ E N +
Sbjct: 1019 KVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQ 1078
Query: 1070 CQAAMLRKDKEGAAL---REDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLAD 1126
+ +K+ E + L ED + + +L+K ++Q +L +E+ + K
Sbjct: 1079 LDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQ 1138
Query: 1127 LDDLNRTKKYLEERL----------IELLRDKDALWQK 1154
DL+R + + ERL +EL + ++A +QK
Sbjct: 1139 RSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQK 1176
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.126 0.346
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,989,484
Number of Sequences: 37866
Number of extensions: 2701981
Number of successful extensions: 51902
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 679
Number of HSP's successfully gapped in prelim test: 1442
Number of HSP's that attempted gapping in prelim test: 18398
Number of HSP's gapped (non-prelim): 12787
length of query: 1478
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1363
effective length of database: 13,892,928
effective search space: 18936060864
effective search space used: 18936060864
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.