Search of human proteins with 157502181

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157502181 two pore segment channel 2 [Homo sapiens]
         (752 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157502181 two pore segment channel 2 [Homo sapiens]               1507   0.0  
gi|219689113 two pore segment channel 1 isoform 1 [Homo sapiens]      187   4e-47
gi|29725622 two pore segment channel 1 isoform 2 [Homo sapiens]       187   4e-47
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1...   101   3e-21
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1...   101   3e-21
gi|193788542 calcium channel, voltage-dependent, L type, alpha 1...   101   3e-21
gi|193788538 calcium channel, voltage-dependent, L type, alpha 1...   101   3e-21
gi|193788536 calcium channel, voltage-dependent, L type, alpha 1...   101   3e-21
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1...   101   3e-21
gi|193794830 calcium channel, voltage-dependent, L type, alpha 1...   101   3e-21
gi|193788530 calcium channel, voltage-dependent, L type, alpha 1...   101   3e-21
gi|193788732 calcium channel, voltage-dependent, L type, alpha 1...    98   2e-20
gi|193788728 calcium channel, voltage-dependent, L type, alpha 1...    98   2e-20
gi|120433602 calcium channel, voltage-dependent, L type, alpha 1...    98   2e-20
gi|193788544 calcium channel, voltage-dependent, L type, alpha 1...    98   2e-20
gi|193788540 calcium channel, voltage-dependent, L type, alpha 1...    98   2e-20
gi|193794832 calcium channel, voltage-dependent, L type, alpha 1...    98   2e-20
gi|193788532 calcium channel, voltage-dependent, L type, alpha 1...    98   2e-20
gi|193788528 calcium channel, voltage-dependent, L type, alpha 1...    98   2e-20
gi|193794828 calcium channel, voltage-dependent, L type, alpha 1...    98   2e-20
gi|193788724 calcium channel, voltage-dependent, L type, alpha 1...    94   4e-19
gi|193788720 calcium channel, voltage-dependent, L type, alpha 1...    94   4e-19
gi|193788526 calcium channel, voltage-dependent, L type, alpha 1...    94   4e-19
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H...    92   1e-18
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H...    92   1e-18
gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E...    92   2e-18
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i...    91   3e-18
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i...    91   3e-18
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i...    91   3e-18
gi|38505280 voltage-dependent calcium channel alpha 1G subunit i...    91   3e-18

>gi|157502181 two pore segment channel 2 [Homo sapiens]
          Length = 752

 Score = 1507 bits (3901), Expect = 0.0
 Identities = 752/752 (100%), Positives = 752/752 (100%)

Query: 1   MAEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYR 60
           MAEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYR
Sbjct: 1   MAEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYR 60

Query: 61  SINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP 120
           SINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP
Sbjct: 61  SINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP 120

Query: 121 PCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC 180
           PCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC
Sbjct: 121 PCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC 180

Query: 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
           HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG
Sbjct: 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240

Query: 241 GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGS 300
           GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGS
Sbjct: 241 GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGS 300

Query: 301 LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ 360
           LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ
Sbjct: 301 LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ 360

Query: 361 NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSP 420
           NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSP
Sbjct: 361 NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSP 420

Query: 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
           FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY
Sbjct: 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480

Query: 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
           LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL
Sbjct: 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540

Query: 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
           WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL
Sbjct: 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600

Query: 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD 660
           FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD
Sbjct: 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD 660

Query: 661 AYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM 720
           AYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM
Sbjct: 661 AYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM 720

Query: 721 TVELLFRDILEEPGEDELTERLSQHPHLWLCR 752
           TVELLFRDILEEPGEDELTERLSQHPHLWLCR
Sbjct: 721 TVELLFRDILEEPGEDELTERLSQHPHLWLCR 752


>gi|219689113 two pore segment channel 1 isoform 1 [Homo sapiens]
          Length = 888

 Score =  187 bits (474), Expect = 4e-47
 Identities = 173/684 (25%), Positives = 306/684 (44%), Gaps = 76/684 (11%)

Query: 39  AARWDLCIDQAVVFIEDAIQY-RSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLA 97
           A  W++   +A +++++     +   H  DA ++  Y   ++++       T  L+L L+
Sbjct: 136 AHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLLLLS 195

Query: 98  FIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLW 157
             E P+       +   A           ++E+  L+V   +L +K    G   F ++  
Sbjct: 196 LCEAPAVPALRLGIYVHA-----------TLELFALMVVVFELCMKLRWLGLHTFIRHKR 244

Query: 158 LLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLL--QNSSMMKKTLKCIRWSLPE 215
            +    VLVV  V+  V L       +R+ R LR  FL+  +    +++ L+ I  SLP 
Sbjct: 245 TMVKTSVLVVQFVEAIVVLVRQMSH-VRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPP 303

Query: 216 MASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNP 275
              + LLL   + +F + G  LF+    D         YF  L  S+ SL VLLTTAN P
Sbjct: 304 FMDILLLLLFFMIIFAILGFYLFSPNPSDP--------YFSTLENSIVSLFVLLTTANFP 355

Query: 276 DVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTR 335
           DVM+P+YS+N    +FFIV+  I   F+MNLL A+++  F     +  ++ L  +R   +
Sbjct: 356 DVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQ 415

Query: 336 AAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEE 395
            A+ +L S        P  +  +    L    K ++ +  +    + +    + LLS ++
Sbjct: 416 HAYRLLISQ-----RRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKD 470

Query: 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVL 455
           F  ++ E+     K    R  +     ++A  +F         N++  +      ++LV+
Sbjct: 471 FYDIY-EVAALKWKAKKNREHWFDELPRTALLIFKGI------NILVKSKAFQYFMYLVV 523

Query: 456 DADVLPAERDDFILGILN----------CVFIVYYLLEMLLKVFALGLRGYLSYPSNVFD 505
             + +    + F+L   N           VF+  Y +E+ LKV  LG   YLS   N+FD
Sbjct: 524 AVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFD 583

Query: 506 GLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKL- 564
             +TV                        +GLL+L         ++V R L+++   KL 
Sbjct: 584 FSVTVF---------------------AFLGLLALALNMEPFYFIVVLRPLQLLRLFKLK 622

Query: 565 --MAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSL---APANG 619
                V  T+  L+  M + G  L++ YY FAI+G+  F G++     N+S    A    
Sbjct: 623 ERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWR 682

Query: 620 SAPCGS---FEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVL 676
           +   G+    E+  Y+ NNFD+   + VTL+ L VVNNW + ++     +  WS++YF+ 
Sbjct: 683 NHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMT 742

Query: 677 WWLVSSVIWVNLFLALILENFLHK 700
           +++V+ V+ + + +A ILE F+ +
Sbjct: 743 FYIVTMVV-MTIIVAFILEAFVFR 765


>gi|29725622 two pore segment channel 1 isoform 2 [Homo sapiens]
          Length = 816

 Score =  187 bits (474), Expect = 4e-47
 Identities = 173/684 (25%), Positives = 306/684 (44%), Gaps = 76/684 (11%)

Query: 39  AARWDLCIDQAVVFIEDAIQY-RSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLA 97
           A  W++   +A +++++     +   H  DA ++  Y   ++++       T  L+L L+
Sbjct: 64  AHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLLLLS 123

Query: 98  FIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLW 157
             E P+       +   A           ++E+  L+V   +L +K    G   F ++  
Sbjct: 124 LCEAPAVPALRLGIYVHA-----------TLELFALMVVVFELCMKLRWLGLHTFIRHKR 172

Query: 158 LLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLL--QNSSMMKKTLKCIRWSLPE 215
            +    VLVV  V+  V L       +R+ R LR  FL+  +    +++ L+ I  SLP 
Sbjct: 173 TMVKTSVLVVQFVEAIVVLVRQMSH-VRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPP 231

Query: 216 MASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNP 275
              + LLL   + +F + G  LF+    D         YF  L  S+ SL VLLTTAN P
Sbjct: 232 FMDILLLLLFFMIIFAILGFYLFSPNPSDP--------YFSTLENSIVSLFVLLTTANFP 283

Query: 276 DVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTR 335
           DVM+P+YS+N    +FFIV+  I   F+MNLL A+++  F     +  ++ L  +R   +
Sbjct: 284 DVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQ 343

Query: 336 AAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEE 395
            A+ +L S        P  +  +    L    K ++ +  +    + +    + LLS ++
Sbjct: 344 HAYRLLISQ-----RRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKD 398

Query: 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVL 455
           F  ++ E+     K    R  +     ++A  +F         N++  +      ++LV+
Sbjct: 399 FYDIY-EVAALKWKAKKNREHWFDELPRTALLIFKGI------NILVKSKAFQYFMYLVV 451

Query: 456 DADVLPAERDDFILGILN----------CVFIVYYLLEMLLKVFALGLRGYLSYPSNVFD 505
             + +    + F+L   N           VF+  Y +E+ LKV  LG   YLS   N+FD
Sbjct: 452 AVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFD 511

Query: 506 GLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKL- 564
             +TV                        +GLL+L         ++V R L+++   KL 
Sbjct: 512 FSVTVF---------------------AFLGLLALALNMEPFYFIVVLRPLQLLRLFKLK 550

Query: 565 --MAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSL---APANG 619
                V  T+  L+  M + G  L++ YY FAI+G+  F G++     N+S    A    
Sbjct: 551 ERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWR 610

Query: 620 SAPCGS---FEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVL 676
           +   G+    E+  Y+ NNFD+   + VTL+ L VVNNW + ++     +  WS++YF+ 
Sbjct: 611 NHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMT 670

Query: 677 WWLVSSVIWVNLFLALILENFLHK 700
           +++V+ V+ + + +A ILE F+ +
Sbjct: 671 FYIVTMVV-MTIIVAFILEAFVFR 693


>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 4 [Homo sapiens]
          Length = 2173

 Score =  101 bits (251), Expect = 3e-21
 Identities = 163/708 (23%), Positives = 295/708 (41%), Gaps = 107/708 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + ILG  + VF   + LE++LK+ A G  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYG-- 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
             +L   S   +    + LLV+ +S ++       G +   +      ++ ++L +L V R
Sbjct: 957  AFLHKGSFCRNYFNILDLLVVSVSLISF------GIQSSAI------NVVKILRVLRVLR 1004

Query: 555  FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGN 611
             LR I   K +  V   V   +   R  G I++V   + ++FA IG+ LF+G +     +
Sbjct: 1005 PLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061

Query: 612  SSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
            S    A       +++         Q   W N   +FD+  AA++ L+ +     W   L
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121

Query: 660  ----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
                D++    GP         I+F+++ ++ +   +N+F+  ++  F
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 131/653 (20%), Positives = 259/653 (39%), Gaps = 139/653 (21%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAGGK---------------QDD----------------------GQD-- 248
            ++ + G+ LF G                 +DD                      G D  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339

Query: 249 RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
           +  +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F+
Sbjct: 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396

Query: 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
           +NL+  ++  +F     K+     F++    R   ++   + G      QA  + P+N  
Sbjct: 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453

Query: 364 QVL-QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
           + + ++   + S   +  E V +    G  +       +L + + +S    +  R  +  
Sbjct: 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511

Query: 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
              +  +       F +L   +   N ++I        + L   +D       N   +  
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566

Query: 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
           +  EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L       
Sbjct: 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619

Query: 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY-- 590
             V LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++  
Sbjct: 620 RCVRLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLF 661

Query: 591 -YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
             +F+++G+ LF G                     +F++++   + FD+F  +L+T++ +
Sbjct: 662 IIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQI 702

Query: 650 MVVNNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
           +   +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 124/690 (17%), Positives = 272/690 (39%), Gaps = 177/690 (25%)

Query: 82   CQRTLSFTIFLILFLAFIETPS-SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
            C R ++ TIF  L L FI   S SL +   V++ +        +  + + +   +F  ++
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH----ILGNADYVFTSIFTLEI 948

Query: 141  SVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFL 195
             +K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+LRP   
Sbjct: 949  ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 196  LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------GKQDDGQ 247
            +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         KQ + +
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 248  DRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
             +   +TY                     F N+  ++ +L  + T    P+++       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P Y+     +IFFI++ +I + F+MN+        F G+++ + Q          
Sbjct: 1129 TEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-------- 1172

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                       GE                Q  +  +LD + +Q +   +++         
Sbjct: 1173 -----------GE----------------QEYKNCELDKNQRQCVEYALKA--------- 1196

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI----- 449
                         ++ + P+ ++Q        ++    YF+YL  ++ L N + +     
Sbjct: 1197 -----------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1241

Query: 450  ---CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG 506
               C+F +              + ILN +F   + +EM+LK+ A   + Y     N FD 
Sbjct: 1242 GQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDA 1288

Query: 507  LLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMA 566
            L+ VV  +++I+   V    H    P M    +         +  V R ++++   + + 
Sbjct: 1289 LI-VVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIR 1347

Query: 567  VVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSF 626
             +  T +   Q +     ++V++++++A+IG+ +F  + +     +     N +      
Sbjct: 1348 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL-----NDTTEINRN------ 1396

Query: 627  EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------------------DAYRRYSG 667
                   NNF  F  A++ L+       WQ  +                   +       
Sbjct: 1397 -------NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS 1449

Query: 668  PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
             ++  YF+ ++++ + + +NLF+A+I++NF
Sbjct: 1450 SFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 45/296 (15%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408


>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 20 [Homo sapiens]
          Length = 2127

 Score =  101 bits (251), Expect = 3e-21
 Identities = 163/708 (23%), Positives = 295/708 (41%), Gaps = 107/708 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + ILG  + VF   + LE++LK+ A G  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYG-- 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
             +L   S   +    + LLV+ +S ++       G +   +      ++ ++L +L V R
Sbjct: 957  AFLHKGSFCRNYFNILDLLVVSVSLISF------GIQSSAI------NVVKILRVLRVLR 1004

Query: 555  FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGN 611
             LR I   K +  V   V   +   R  G I++V   + ++FA IG+ LF+G +     +
Sbjct: 1005 PLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061

Query: 612  SSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
            S    A       +++         Q   W N   +FD+  AA++ L+ +     W   L
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121

Query: 660  ----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
                D++    GP         I+F+++ ++ +   +N+F+  ++  F
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 131/653 (20%), Positives = 259/653 (39%), Gaps = 139/653 (21%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAGGK---------------QDD----------------------GQD-- 248
            ++ + G+ LF G                 +DD                      G D  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339

Query: 249 RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
           +  +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F+
Sbjct: 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396

Query: 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
           +NL+  ++  +F     K+     F++    R   ++   + G      QA  + P+N  
Sbjct: 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453

Query: 364 QVL-QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
           + + ++   + S   +  E V +    G  +       +L + + +S    +  R  +  
Sbjct: 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511

Query: 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
              +  +       F +L   +   N ++I        + L   +D       N   +  
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566

Query: 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
           +  EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L       
Sbjct: 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619

Query: 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY-- 590
             V LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++  
Sbjct: 620 RCVRLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLF 661

Query: 591 -YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
             +F+++G+ LF G                     +F++++   + FD+F  +L+T++ +
Sbjct: 662 IIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQI 702

Query: 650 MVVNNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
           +   +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 123/690 (17%), Positives = 272/690 (39%), Gaps = 188/690 (27%)

Query: 82   CQRTLSFTIFLILFLAFIETPS-SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
            C R ++ TIF  L L FI   S SL +   V++ +        +  + + +   +F  ++
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH----ILGNADYVFTSIFTLEI 948

Query: 141  SVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFL 195
             +K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+LRP   
Sbjct: 949  ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 196  LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------GKQDDGQ 247
            +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         KQ + +
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 248  DRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
             +   +TY                     F N+  ++ +L  + T    P+++       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P Y+     +IFFI++ +I + F+MN+        F G+++ + Q          
Sbjct: 1129 TEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-------- 1172

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                       GE                Q  +  +LD + +Q +   +++         
Sbjct: 1173 -----------GE----------------QEYKNCELDKNQRQCVEYALKA--------- 1196

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI----- 449
                         ++ + P+ ++Q        ++    YF+YL  ++ L N + +     
Sbjct: 1197 -----------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1241

Query: 450  ---CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG 506
               C+F +              + ILN +F   + +EM+LK+ A   + Y     N FD 
Sbjct: 1242 GQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDA 1288

Query: 507  LLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMA 566
            L+ VV  +++I+   V          E    +S+        +  V R ++++   + + 
Sbjct: 1289 LI-VVGSIVDIAITEVN-------NAEENSRISI----TFFRLFRVMRLVKLLSRGEGIR 1336

Query: 567  VVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSF 626
             +  T +   Q +     ++V++++++A+IG+ +F  + +     +     N +      
Sbjct: 1337 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL-----NDTTEINRN------ 1385

Query: 627  EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------------------DAYRRYSG 667
                   NNF  F  A++ L+       WQ  +                   +       
Sbjct: 1386 -------NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS 1438

Query: 668  PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
             ++  YF+ ++++ + + +NLF+A+I++NF
Sbjct: 1439 SFAVFYFISFYMLCAFLIINLFVAVIMDNF 1468



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 45/296 (15%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408


>gi|193788542 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 17 [Homo sapiens]
          Length = 2138

 Score =  101 bits (251), Expect = 3e-21
 Identities = 163/708 (23%), Positives = 295/708 (41%), Gaps = 107/708 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + ILG  + VF   + LE++LK+ A G  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYG-- 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
             +L   S   +    + LLV+ +S ++       G +   +      ++ ++L +L V R
Sbjct: 957  AFLHKGSFCRNYFNILDLLVVSVSLISF------GIQSSAI------NVVKILRVLRVLR 1004

Query: 555  FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGN 611
             LR I   K +  V   V   +   R  G I++V   + ++FA IG+ LF+G +     +
Sbjct: 1005 PLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061

Query: 612  SSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
            S    A       +++         Q   W N   +FD+  AA++ L+ +     W   L
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121

Query: 660  ----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
                D++    GP         I+F+++ ++ +   +N+F+  ++  F
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 131/653 (20%), Positives = 259/653 (39%), Gaps = 139/653 (21%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAGGK---------------QDD----------------------GQD-- 248
            ++ + G+ LF G                 +DD                      G D  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339

Query: 249 RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
           +  +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F+
Sbjct: 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396

Query: 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
           +NL+  ++  +F     K+     F++    R   ++   + G      QA  + P+N  
Sbjct: 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453

Query: 364 QVL-QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
           + + ++   + S   +  E V +    G  +       +L + + +S    +  R  +  
Sbjct: 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511

Query: 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
              +  +       F +L   +   N ++I        + L   +D       N   +  
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566

Query: 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
           +  EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L       
Sbjct: 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619

Query: 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY-- 590
             V LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++  
Sbjct: 620 RCVRLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLF 661

Query: 591 -YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
             +F+++G+ LF G                     +F++++   + FD+F  +L+T++ +
Sbjct: 662 IIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQI 702

Query: 650 MVVNNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
           +   +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 124/690 (17%), Positives = 272/690 (39%), Gaps = 177/690 (25%)

Query: 82   CQRTLSFTIFLILFLAFIETPS-SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
            C R ++ TIF  L L FI   S SL +   V++ +        +  + + +   +F  ++
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH----ILGNADYVFTSIFTLEI 948

Query: 141  SVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFL 195
             +K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+LRP   
Sbjct: 949  ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 196  LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------GKQDDGQ 247
            +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         KQ + +
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 248  DRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
             +   +TY                     F N+  ++ +L  + T    P+++       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P Y+     +IFFI++ +I + F+MN+        F G+++ + Q          
Sbjct: 1129 TEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-------- 1172

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                       GE                Q  +  +LD + +Q +   +++         
Sbjct: 1173 -----------GE----------------QEYKNCELDKNQRQCVEYALKA--------- 1196

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI----- 449
                         ++ + P+ ++Q        ++    YF+YL  ++ L N + +     
Sbjct: 1197 -----------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1241

Query: 450  ---CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG 506
               C+F +              + ILN +F   + +EM+LK+ A   + Y     N FD 
Sbjct: 1242 GQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDA 1288

Query: 507  LLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMA 566
            L+ VV  +++I+   V    H    P M    +         +  V R ++++   + + 
Sbjct: 1289 LI-VVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIR 1347

Query: 567  VVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSF 626
             +  T +   Q +     ++V++++++A+IG+ +F  + +     +     N +      
Sbjct: 1348 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL-----NDTTEINRN------ 1396

Query: 627  EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------------------DAYRRYSG 667
                   NNF  F  A++ L+       WQ  +                   +       
Sbjct: 1397 -------NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS 1449

Query: 668  PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
             ++  YF+ ++++ + + +NLF+A+I++NF
Sbjct: 1450 SFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 45/296 (15%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408


>gi|193788538 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 15 [Homo sapiens]
          Length = 2138

 Score =  101 bits (251), Expect = 3e-21
 Identities = 163/708 (23%), Positives = 295/708 (41%), Gaps = 107/708 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + ILG  + VF   + LE++LK+ A G  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYG-- 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
             +L   S   +    + LLV+ +S ++       G +   +      ++ ++L +L V R
Sbjct: 957  AFLHKGSFCRNYFNILDLLVVSVSLISF------GIQSSAI------NVVKILRVLRVLR 1004

Query: 555  FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGN 611
             LR I   K +  V   V   +   R  G I++V   + ++FA IG+ LF+G +     +
Sbjct: 1005 PLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061

Query: 612  SSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
            S    A       +++         Q   W N   +FD+  AA++ L+ +     W   L
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121

Query: 660  ----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
                D++    GP         I+F+++ ++ +   +N+F+  ++  F
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 126/693 (18%), Positives = 278/693 (40%), Gaps = 183/693 (26%)

Query: 82   CQRTLSFTIFLILFLAFIETPS-SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
            C R ++ TIF  L L FI   S SL +   V++ +        +  + + +   +F  ++
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH----ILGNADYVFTSIFTLEI 948

Query: 141  SVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFL 195
             +K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+LRP   
Sbjct: 949  ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 196  LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------GKQDDGQ 247
            +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         KQ + +
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 248  DRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
             +   +TY                     F N+  ++ +L  + T    P+++       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P Y+     +IFFI++ +I + F+MN+        F G+++ + Q          
Sbjct: 1129 TEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-------- 1172

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                       GE                Q  +  +LD + +Q +   +++         
Sbjct: 1173 -----------GE----------------QEYKNCELDKNQRQCVEYALKA--------- 1196

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI----- 449
                         ++ + P+ ++Q        ++    YF+YL  ++ L N + +     
Sbjct: 1197 -----------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1241

Query: 450  ---CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG 506
               C+F +              + ILN +F   + +EM+LK+ A   +GY S P NVFD 
Sbjct: 1242 GQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDF 1288

Query: 507  LL---TVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMK 563
            L+   +++ ++L  +  A +    P    E    +S+        +  V R ++++   +
Sbjct: 1289 LIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISI----TFFRLFRVMRLVKLLSRGE 1344

Query: 564  LMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPC 623
             +  +  T +   Q +     ++V++++++A+IG+ +F  + +     +     N +   
Sbjct: 1345 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL-----NDTTEINRN--- 1396

Query: 624  GSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------------------DAYRR 664
                      NNF  F  A++ L+       WQ  +                   +    
Sbjct: 1397 ----------NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETP 1446

Query: 665  YSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
                ++  YF+ ++++ + + +NLF+A+I++NF
Sbjct: 1447 CGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 131/653 (20%), Positives = 259/653 (39%), Gaps = 139/653 (21%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAGGK---------------QDD----------------------GQD-- 248
            ++ + G+ LF G                 +DD                      G D  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339

Query: 249 RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
           +  +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F+
Sbjct: 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396

Query: 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
           +NL+  ++  +F     K+     F++    R   ++   + G      QA  + P+N  
Sbjct: 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453

Query: 364 QVL-QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
           + + ++   + S   +  E V +    G  +       +L + + +S    +  R  +  
Sbjct: 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511

Query: 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
              +  +       F +L   +   N ++I        + L   +D       N   +  
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566

Query: 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
           +  EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L       
Sbjct: 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619

Query: 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY-- 590
             V LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++  
Sbjct: 620 RCVRLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLF 661

Query: 591 -YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
             +F+++G+ LF G                     +F++++   + FD+F  +L+T++ +
Sbjct: 662 IIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQI 702

Query: 650 MVVNNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
           +   +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 45/296 (15%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408


>gi|193788536 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 14 [Homo sapiens]
          Length = 2138

 Score =  101 bits (251), Expect = 3e-21
 Identities = 163/708 (23%), Positives = 295/708 (41%), Gaps = 107/708 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + ILG  + VF   + LE++LK+ A G  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYG-- 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
             +L   S   +    + LLV+ +S ++       G +   +      ++ ++L +L V R
Sbjct: 957  AFLHKGSFCRNYFNILDLLVVSVSLISF------GIQSSAI------NVVKILRVLRVLR 1004

Query: 555  FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGN 611
             LR I   K +  V   V   +   R  G I++V   + ++FA IG+ LF+G +     +
Sbjct: 1005 PLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061

Query: 612  SSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
            S    A       +++         Q   W N   +FD+  AA++ L+ +     W   L
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121

Query: 660  ----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
                D++    GP         I+F+++ ++ +   +N+F+  ++  F
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 124/690 (17%), Positives = 272/690 (39%), Gaps = 177/690 (25%)

Query: 82   CQRTLSFTIFLILFLAFIETPS-SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
            C R ++ TIF  L L FI   S SL +   V++ +        +  + + +   +F  ++
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH----ILGNADYVFTSIFTLEI 948

Query: 141  SVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFL 195
             +K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+LRP   
Sbjct: 949  ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 196  LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------GKQDDGQ 247
            +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         KQ + +
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 248  DRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
             +   +TY                     F N+  ++ +L  + T    P+++       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P Y+     +IFFI++ +I + F+MN+        F G+++ + Q          
Sbjct: 1129 TEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-------- 1172

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                       GE                Q  +  +LD + +Q +   +++         
Sbjct: 1173 -----------GE----------------QEYKNCELDKNQRQCVEYALKA--------- 1196

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI----- 449
                         ++ + P+ ++Q        ++    YF+YL  ++ L N + +     
Sbjct: 1197 -----------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1241

Query: 450  ---CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG 506
               C+F +              + ILN +F   + +EM+LK+ A   + Y     N FD 
Sbjct: 1242 GQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDA 1288

Query: 507  LLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMA 566
            L+ VV  +++I+   V    H    P M    +         +  V R ++++   + + 
Sbjct: 1289 LI-VVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIR 1347

Query: 567  VVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSF 626
             +  T +   Q +     ++V++++++A+IG+ +F  + +     +     N +      
Sbjct: 1348 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL-----NDTTEINRN------ 1396

Query: 627  EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------------------DAYRRYSG 667
                   NNF  F  A++ L+       WQ  +                   +       
Sbjct: 1397 -------NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS 1449

Query: 668  PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
             ++  YF+ ++++ + + +NLF+A+I++NF
Sbjct: 1450 SFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 68/295 (23%), Positives = 129/295 (43%), Gaps = 43/295 (14%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQ---VFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W     ++     Y  PW  +YFV   +  S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWMQDAMGYELPW--VYFVSLVIFGSFFVLNLVLGVLSGEF 408


>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 12 [Homo sapiens]
          Length = 2146

 Score =  101 bits (251), Expect = 3e-21
 Identities = 163/708 (23%), Positives = 295/708 (41%), Gaps = 107/708 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + ILG  + VF   + LE++LK+ A G  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYG-- 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
             +L   S   +    + LLV+ +S ++       G +   +      ++ ++L +L V R
Sbjct: 957  AFLHKGSFCRNYFNILDLLVVSVSLISF------GIQSSAI------NVVKILRVLRVLR 1004

Query: 555  FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGN 611
             LR I   K +  V   V   +   R  G I++V   + ++FA IG+ LF+G +     +
Sbjct: 1005 PLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061

Query: 612  SSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
            S    A       +++         Q   W N   +FD+  AA++ L+ +     W   L
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121

Query: 660  ----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
                D++    GP         I+F+++ ++ +   +N+F+  ++  F
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 131/653 (20%), Positives = 259/653 (39%), Gaps = 139/653 (21%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAGGK---------------QDD----------------------GQD-- 248
            ++ + G+ LF G                 +DD                      G D  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339

Query: 249 RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
           +  +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F+
Sbjct: 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396

Query: 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
           +NL+  ++  +F     K+     F++    R   ++   + G      QA  + P+N  
Sbjct: 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453

Query: 364 QVL-QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
           + + ++   + S   +  E V +    G  +       +L + + +S    +  R  +  
Sbjct: 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511

Query: 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
              +  +       F +L   +   N ++I        + L   +D       N   +  
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566

Query: 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
           +  EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L       
Sbjct: 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619

Query: 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY-- 590
             V LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++  
Sbjct: 620 RCVRLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLF 661

Query: 591 -YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
             +F+++G+ LF G                     +F++++   + FD+F  +L+T++ +
Sbjct: 662 IIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQI 702

Query: 650 MVVNNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
           +   +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 123/690 (17%), Positives = 272/690 (39%), Gaps = 188/690 (27%)

Query: 82   CQRTLSFTIFLILFLAFIETPS-SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
            C R ++ TIF  L L FI   S SL +   V++ +        +  + + +   +F  ++
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH----ILGNADYVFTSIFTLEI 948

Query: 141  SVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFL 195
             +K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+LRP   
Sbjct: 949  ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 196  LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------GKQDDGQ 247
            +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         KQ + +
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 248  DRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
             +   +TY                     F N+  ++ +L  + T    P+++       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P Y+     +IFFI++ +I + F+MN+        F G+++ + Q          
Sbjct: 1129 TEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-------- 1172

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                       GE                Q  +  +LD + +Q +   +++         
Sbjct: 1173 -----------GE----------------QEYKNCELDKNQRQCVEYALKA--------- 1196

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI----- 449
                         ++ + P+ ++Q        ++    YF+YL  ++ L N + +     
Sbjct: 1197 -----------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1241

Query: 450  ---CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG 506
               C+F +              + ILN +F   + +EM+LK+ A   + Y     N FD 
Sbjct: 1242 GQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDA 1288

Query: 507  LLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMA 566
            L+ VV  +++I+   V          E    +S+        +  V R ++++   + + 
Sbjct: 1289 LI-VVGSIVDIAITEVN-------NAEENSRISI----TFFRLFRVMRLVKLLSRGEGIR 1336

Query: 567  VVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSF 626
             +  T +   Q +     ++V++++++A+IG+ +F  + +     +     N +      
Sbjct: 1337 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL-----NDTTEINRN------ 1385

Query: 627  EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------------------DAYRRYSG 667
                   NNF  F  A++ L+       WQ  +                   +       
Sbjct: 1386 -------NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS 1438

Query: 668  PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
             ++  YF+ ++++ + + +NLF+A+I++NF
Sbjct: 1439 SFAVFYFISFYMLCAFLIINLFVAVIMDNF 1468



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 45/296 (15%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408


>gi|193794830 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 10 [Homo sapiens]
          Length = 2155

 Score =  101 bits (251), Expect = 3e-21
 Identities = 163/708 (23%), Positives = 295/708 (41%), Gaps = 107/708 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + ILG  + VF   + LE++LK+ A G  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYG-- 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
             +L   S   +    + LLV+ +S ++       G +   +      ++ ++L +L V R
Sbjct: 957  AFLHKGSFCRNYFNILDLLVVSVSLISF------GIQSSAI------NVVKILRVLRVLR 1004

Query: 555  FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGN 611
             LR I   K +  V   V   +   R  G I++V   + ++FA IG+ LF+G +     +
Sbjct: 1005 PLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061

Query: 612  SSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
            S    A       +++         Q   W N   +FD+  AA++ L+ +     W   L
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121

Query: 660  ----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
                D++    GP         I+F+++ ++ +   +N+F+  ++  F
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 131/653 (20%), Positives = 259/653 (39%), Gaps = 139/653 (21%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAGGK---------------QDD----------------------GQD-- 248
            ++ + G+ LF G                 +DD                      G D  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339

Query: 249 RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
           +  +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F+
Sbjct: 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396

Query: 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
           +NL+  ++  +F     K+     F++    R   ++   + G      QA  + P+N  
Sbjct: 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453

Query: 364 QVL-QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
           + + ++   + S   +  E V +    G  +       +L + + +S    +  R  +  
Sbjct: 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511

Query: 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
              +  +       F +L   +   N ++I        + L   +D       N   +  
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566

Query: 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
           +  EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L       
Sbjct: 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619

Query: 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY-- 590
             V LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++  
Sbjct: 620 RCVRLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLF 661

Query: 591 -YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
             +F+++G+ LF G                     +F++++   + FD+F  +L+T++ +
Sbjct: 662 IIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQI 702

Query: 650 MVVNNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
           +   +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 130/707 (18%), Positives = 280/707 (39%), Gaps = 194/707 (27%)

Query: 82   CQRTLSFTIFLILFLAFIETPS-SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
            C R ++ TIF  L L FI   S SL +   V++ +        +  + + +   +F  ++
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH----ILGNADYVFTSIFTLEI 948

Query: 141  SVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFL 195
             +K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+LRP   
Sbjct: 949  ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 196  LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------GKQDDGQ 247
            +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         KQ + +
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 248  DRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
             +   +TY                     F N+  ++ +L  + T    P+++       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P Y+     +IFFI++ +I + F+MN+        F G+++ + Q          
Sbjct: 1129 TEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-------- 1172

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                       GE                Q  +  +LD + +Q +   +++         
Sbjct: 1173 -----------GE----------------QEYKNCELDKNQRQCVEYALKA--------- 1196

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI----- 449
                         ++ + P+ ++Q        ++    YF+YL  ++ L N + +     
Sbjct: 1197 -----------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1241

Query: 450  ---CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG 506
               C+F +              + ILN +F   + +EM+LK+ A   +GY S P NVFD 
Sbjct: 1242 GQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFD- 1287

Query: 507  LLTVVLLVLEISTLAVYRLPHPGWRP----EMVGLLSLWDMTRMLN-------MLIVFRF 555
             L V+  ++++            W       +VG +    +T + N        +  FR 
Sbjct: 1288 FLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRL 1347

Query: 556  LRIIPSMKLMA------VVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
             R++  +KL++       +  T +   Q +     ++V++++++A+IG+ +F  + +   
Sbjct: 1348 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL--- 1404

Query: 610  GNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL---------- 659
              +     N +             NNF  F  A++ L+       WQ  +          
Sbjct: 1405 --NDTTEINRN-------------NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCA 1449

Query: 660  ---------DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
                     +        ++  YF+ ++++ + + +NLF+A+I++NF
Sbjct: 1450 PESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1496



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 45/296 (15%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 57/271 (21%), Positives = 110/271 (40%), Gaps = 30/271 (11%)

Query: 69   SSMWLYRRYYSNVCQRTLSFTIFLILF--LAFIETPSSLTSTADVRYRAAPWEPPCGLTE 126
            +++ L  ++Y   C   ++  I  +LF  L  +E    L +     Y + PW     L  
Sbjct: 1232 NTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIV 1291

Query: 127  SVEVLCLLVFAADLSVKGYLF--GWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPL 184
               ++ ++     LS   + F   W  F   L ++G +V + ++ V+     S +     
Sbjct: 1292 IGSIIDVI-----LSETNHYFCDAWNTFDA-LIVVGSIVDIAITEVNNAEENSRISITFF 1345

Query: 185  RIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQD 244
            R+ R++R   LL     ++  L     S   +  V LL+ +   ++ + GM +F     +
Sbjct: 1346 RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN 1405

Query: 245  DGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMI-------------PAYSK------N 285
            D  +  R   FQ  P+++  L    T     D+M+             P+ S        
Sbjct: 1406 DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCG 1465

Query: 286  RAYAIF-FIVFTVIGSLFLMNLLTAIIYSQF 315
             ++A+F FI F ++ +  ++NL  A+I   F
Sbjct: 1466 SSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1496


>gi|193788530 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 9 [Homo sapiens]
          Length = 2157

 Score =  101 bits (251), Expect = 3e-21
 Identities = 163/708 (23%), Positives = 295/708 (41%), Gaps = 107/708 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + ILG  + VF   + LE++LK+ A G  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYG-- 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
             +L   S   +    + LLV+ +S ++       G +   +      ++ ++L +L V R
Sbjct: 957  AFLHKGSFCRNYFNILDLLVVSVSLISF------GIQSSAI------NVVKILRVLRVLR 1004

Query: 555  FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGN 611
             LR I   K +  V   V   +   R  G I++V   + ++FA IG+ LF+G +     +
Sbjct: 1005 PLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061

Query: 612  SSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
            S    A       +++         Q   W N   +FD+  AA++ L+ +     W   L
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121

Query: 660  ----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
                D++    GP         I+F+++ ++ +   +N+F+  ++  F
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 131/653 (20%), Positives = 259/653 (39%), Gaps = 139/653 (21%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAGGK---------------QDD----------------------GQD-- 248
            ++ + G+ LF G                 +DD                      G D  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339

Query: 249 RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
           +  +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F+
Sbjct: 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396

Query: 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
           +NL+  ++  +F     K+     F++    R   ++   + G      QA  + P+N  
Sbjct: 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453

Query: 364 QVL-QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
           + + ++   + S   +  E V +    G  +       +L + + +S    +  R  +  
Sbjct: 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511

Query: 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
              +  +       F +L   +   N ++I        + L   +D       N   +  
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566

Query: 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
           +  EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L       
Sbjct: 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619

Query: 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY-- 590
             V LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++  
Sbjct: 620 RCVRLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLF 661

Query: 591 -YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
             +F+++G+ LF G                     +F++++   + FD+F  +L+T++ +
Sbjct: 662 IIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQI 702

Query: 650 MVVNNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
           +   +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 124/690 (17%), Positives = 272/690 (39%), Gaps = 177/690 (25%)

Query: 82   CQRTLSFTIFLILFLAFIETPS-SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
            C R ++ TIF  L L FI   S SL +   V++ +        +  + + +   +F  ++
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH----ILGNADYVFTSIFTLEI 948

Query: 141  SVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFL 195
             +K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+LRP   
Sbjct: 949  ILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 196  LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------GKQDDGQ 247
            +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         KQ + +
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 248  DRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
             +   +TY                     F N+  ++ +L  + T    P+++       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P Y+     +IFFI++ +I + F+MN+        F G+++ + Q          
Sbjct: 1129 TEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-------- 1172

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                       GE                Q  +  +LD + +Q +   +++         
Sbjct: 1173 -----------GE----------------QEYKNCELDKNQRQCVEYALKA--------- 1196

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI----- 449
                         ++ + P+ ++Q        ++    YF+YL  ++ L N + +     
Sbjct: 1197 -----------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1241

Query: 450  ---CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG 506
               C+F +              + ILN +F   + +EM+LK+ A   + Y     N FD 
Sbjct: 1242 GQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDA 1288

Query: 507  LLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMA 566
            L+ VV  +++I+   V    H    P M    +         +  V R ++++   + + 
Sbjct: 1289 LI-VVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIR 1347

Query: 567  VVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSF 626
             +  T +   Q +     ++V++++++A+IG+ +F  + +     +     N +      
Sbjct: 1348 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL-----NDTTEINRN------ 1396

Query: 627  EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------------------DAYRRYSG 667
                   NNF  F  A++ L+       WQ  +                   +       
Sbjct: 1397 -------NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS 1449

Query: 668  PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
             ++  YF+ ++++ + + +NLF+A+I++NF
Sbjct: 1450 SFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 45/296 (15%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408


>gi|193788732 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 5 [Homo sapiens]
          Length = 2166

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 161/708 (22%), Positives = 293/708 (41%), Gaps = 107/708 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + IL   + VF   + +E+ LK+ A G  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYG-- 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
             +L   S   +    + LLV+ +S ++       G +   +      ++ ++L +L V R
Sbjct: 957  AFLHKGSFCRNYFNILDLLVVSVSLISF------GIQSSAI------NVVKILRVLRVLR 1004

Query: 555  FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGN 611
             LR I   K +  V   V   +   R  G I++V   + ++FA IG+ LF+G +     +
Sbjct: 1005 PLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061

Query: 612  SSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
            S    A       +++         Q   W N   +FD+  AA++ L+ +     W   L
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121

Query: 660  ----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
                D++    GP         I+F+++ ++ +   +N+F+  ++  F
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 131/653 (20%), Positives = 259/653 (39%), Gaps = 139/653 (21%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAGGK---------------QDD----------------------GQD-- 248
            ++ + G+ LF G                 +DD                      G D  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339

Query: 249 RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
           +  +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F+
Sbjct: 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396

Query: 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
           +NL+  ++  +F     K+     F++    R   ++   + G      QA  + P+N  
Sbjct: 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453

Query: 364 QVL-QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
           + + ++   + S   +  E V +    G  +       +L + + +S    +  R  +  
Sbjct: 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511

Query: 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
              +  +       F +L   +   N ++I        + L   +D       N   +  
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566

Query: 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
           +  EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L       
Sbjct: 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619

Query: 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY-- 590
             V LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++  
Sbjct: 620 RCVRLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLF 661

Query: 591 -YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
             +F+++G+ LF G                     +F++++   + FD+F  +L+T++ +
Sbjct: 662 IIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQI 702

Query: 650 MVVNNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
           +   +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 129/717 (17%), Positives = 277/717 (38%), Gaps = 203/717 (28%)

Query: 82   CQRTLSFTIFLILFLAFIETPS-SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
            C R ++ TIF  L L FI   S SL +   V++ +        +    +++   +F  ++
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH----ILFYFDIVFTTIFTIEI 948

Query: 141  SVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFL 195
            ++K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+LRP   
Sbjct: 949  ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 196  LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------GKQDDGQ 247
            +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         KQ + +
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 248  DRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
             +   +TY                     F N+  ++ +L  + T    P+++       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P Y+     +IFFI++ +I + F+MN+        F G+++ + Q          
Sbjct: 1129 TEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-------- 1172

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                       GE                Q  +  +LD + +Q +   +++         
Sbjct: 1173 -----------GE----------------QEYKNCELDKNQRQCVEYALKA--------- 1196

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI----- 449
                         ++ + P+ ++Q        ++    YF+YL  ++ L N + +     
Sbjct: 1197 -----------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1241

Query: 450  ---CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG 506
               C+F +              + ILN +F   + +EM+LK+ A   +GY S P NVFD 
Sbjct: 1242 GQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDF 1288

Query: 507  L---------------------------LTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
            L                           L VV  +++I+   V    H    P M    +
Sbjct: 1289 LIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEEN 1348

Query: 540  LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
                     +  V R ++++   + +  +  T +   Q +     ++V++++++A+IG+ 
Sbjct: 1349 SRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ 1408

Query: 600  LFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL 659
            +F  + +     +     N +             NNF  F  A++ L+       WQ  +
Sbjct: 1409 VFGKIAL-----NDTTEINRN-------------NNFQTFPQAVLLLFRCATGEAWQDIM 1450

Query: 660  -------------------DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
                               +        ++  YF+ ++++ + + +NLF+A+I++NF
Sbjct: 1451 LACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1507



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 45/296 (15%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408


>gi|193788728 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 3 [Homo sapiens]
          Length = 2179

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 161/708 (22%), Positives = 293/708 (41%), Gaps = 107/708 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + IL   + VF   + +E+ LK+ A G  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYG-- 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
             +L   S   +    + LLV+ +S ++       G +   +      ++ ++L +L V R
Sbjct: 957  AFLHKGSFCRNYFNILDLLVVSVSLISF------GIQSSAI------NVVKILRVLRVLR 1004

Query: 555  FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGN 611
             LR I   K +  V   V   +   R  G I++V   + ++FA IG+ LF+G +     +
Sbjct: 1005 PLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061

Query: 612  SSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
            S    A       +++         Q   W N   +FD+  AA++ L+ +     W   L
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121

Query: 660  ----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
                D++    GP         I+F+++ ++ +   +N+F+  ++  F
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 131/653 (20%), Positives = 259/653 (39%), Gaps = 139/653 (21%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAGGK---------------QDD----------------------GQD-- 248
            ++ + G+ LF G                 +DD                      G D  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339

Query: 249 RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
           +  +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F+
Sbjct: 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396

Query: 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
           +NL+  ++  +F     K+     F++    R   ++   + G      QA  + P+N  
Sbjct: 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453

Query: 364 QVL-QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
           + + ++   + S   +  E V +    G  +       +L + + +S    +  R  +  
Sbjct: 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511

Query: 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
              +  +       F +L   +   N ++I        + L   +D       N   +  
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566

Query: 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
           +  EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L       
Sbjct: 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619

Query: 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY-- 590
             V LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++  
Sbjct: 620 RCVRLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLF 661

Query: 591 -YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
             +F+++G+ LF G                     +F++++   + FD+F  +L+T++ +
Sbjct: 662 IIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQI 702

Query: 650 MVVNNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
           +   +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 129/714 (18%), Positives = 280/714 (39%), Gaps = 203/714 (28%)

Query: 82   CQRTLSFTIFLILFLAFIETPS-SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
            C R ++ TIF  L L FI   S SL +   V++ +        +    +++   +F  ++
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH----ILFYFDIVFTTIFTIEI 948

Query: 141  SVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFL 195
            ++K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+LRP   
Sbjct: 949  ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 196  LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------GKQDDGQ 247
            +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         KQ + +
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 248  DRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
             +   +TY                     F N+  ++ +L  + T    P+++       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P Y+     +IFFI++ +I + F+MN+        F G+++ + Q          
Sbjct: 1129 TEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-------- 1172

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                       GE                Q  +  +LD + +Q +   +++         
Sbjct: 1173 -----------GE----------------QEYKNCELDKNQRQCVEYALKA--------- 1196

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI----- 449
                         ++ + P+ ++Q        ++    YF+YL  ++ L N + +     
Sbjct: 1197 -----------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1241

Query: 450  ---CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG 506
               C+F +              + ILN +F   + +EM+LK+ A   + Y     N FD 
Sbjct: 1242 GQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDA 1288

Query: 507  LLTVVLLVLEISTLAVYRLPHPGWRPEM------------------VGLLSLWDMTRMLN 548
            L+ VV  +++I+   V    H    P M                   G  +  + +R+  
Sbjct: 1289 LI-VVGSIVDIAITEVNPAEHTQCSPSMGPSCSHPPLAVLTAPPVADGFQNAEENSRI-- 1345

Query: 549  MLIVFRFLRIIPSMKLMA------VVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFR 602
             +  FR  R++  +KL++       +  T +   Q +     ++V++++++A+IG+ +F 
Sbjct: 1346 SITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFG 1405

Query: 603  GVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL--- 659
             + +     +     N +             NNF  F  A++ L+       WQ  +   
Sbjct: 1406 KIAL-----NDTTEINRN-------------NNFQTFPQAVLLLFRCATGEAWQDIMLAC 1447

Query: 660  ----------------DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
                            +        ++  YF+ ++++ + + +NLF+A+I++NF
Sbjct: 1448 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1501



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 45/296 (15%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408


>gi|120433602 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 18 [Homo sapiens]
          Length = 2138

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 161/708 (22%), Positives = 293/708 (41%), Gaps = 107/708 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + IL   + VF   + +E+ LK+ A G  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYG-- 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
             +L   S   +    + LLV+ +S ++       G +   +      ++ ++L +L V R
Sbjct: 957  AFLHKGSFCRNYFNILDLLVVSVSLISF------GIQSSAI------NVVKILRVLRVLR 1004

Query: 555  FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGN 611
             LR I   K +  V   V   +   R  G I++V   + ++FA IG+ LF+G +     +
Sbjct: 1005 PLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061

Query: 612  SSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
            S    A       +++         Q   W N   +FD+  AA++ L+ +     W   L
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121

Query: 660  ----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
                D++    GP         I+F+++ ++ +   +N+F+  ++  F
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 124/690 (17%), Positives = 273/690 (39%), Gaps = 177/690 (25%)

Query: 82   CQRTLSFTIFLILFLAFIETPS-SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
            C R ++ TIF  L L FI   S SL +   V++ +        +    +++   +F  ++
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH----ILFYFDIVFTTIFTIEI 948

Query: 141  SVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFL 195
            ++K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+LRP   
Sbjct: 949  ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 196  LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------GKQDDGQ 247
            +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         KQ + +
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 248  DRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
             +   +TY                     F N+  ++ +L  + T    P+++       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P Y+     +IFFI++ +I + F+MN+        F G+++ + Q          
Sbjct: 1129 TEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-------- 1172

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                       GE                Q  +  +LD + +Q +   +++         
Sbjct: 1173 -----------GE----------------QEYKNCELDKNQRQCVEYALKA--------- 1196

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI----- 449
                         ++ + P+ ++Q        ++    YF+YL  ++ L N + +     
Sbjct: 1197 -----------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1241

Query: 450  ---CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG 506
               C+F +              + ILN +F   + +EM+LK+ A   + Y     N FD 
Sbjct: 1242 GQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDA 1288

Query: 507  LLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMA 566
            L+ VV  +++I+   V    H    P M    +         +  V R ++++   + + 
Sbjct: 1289 LI-VVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIR 1347

Query: 567  VVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSF 626
             +  T +   Q +     ++V++++++A+IG+ +F  + +     +     N +      
Sbjct: 1348 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL-----NDTTEINRN------ 1396

Query: 627  EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------------------DAYRRYSG 667
                   NNF  F  A++ L+       WQ  +                   +       
Sbjct: 1397 -------NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS 1449

Query: 668  PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
             ++  YF+ ++++ + + +NLF+A+I++NF
Sbjct: 1450 SFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 131/653 (20%), Positives = 259/653 (39%), Gaps = 139/653 (21%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAGGK---------------QDD----------------------GQD-- 248
            ++ + G+ LF G                 +DD                      G D  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339

Query: 249 RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
           +  +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F+
Sbjct: 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396

Query: 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
           +NL+  ++  +F     K+     F++    R   ++   + G      QA  + P+N  
Sbjct: 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453

Query: 364 QVL-QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
           + + ++   + S   +  E V +    G  +       +L + + +S    +  R  +  
Sbjct: 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511

Query: 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
              +  +       F +L   +   N ++I        + L   +D       N   +  
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566

Query: 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
           +  EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L       
Sbjct: 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619

Query: 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY-- 590
             V LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++  
Sbjct: 620 RCVRLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLF 661

Query: 591 -YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
             +F+++G+ LF G                     +F++++   + FD+F  +L+T++ +
Sbjct: 662 IIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQI 702

Query: 650 MVVNNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
           +   +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 45/296 (15%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408


>gi|193788544 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 19 [Homo sapiens]
          Length = 2135

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 161/708 (22%), Positives = 293/708 (41%), Gaps = 107/708 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 492  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 547

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 548  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 605

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 606  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 665

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 666  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 724

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 725  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 784

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 785  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 838

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 839  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 898

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + IL   + VF   + +E+ LK+ A G  
Sbjct: 899  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYG-- 953

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
             +L   S   +    + LLV+ +S ++       G +   +      ++ ++L +L V R
Sbjct: 954  AFLHKGSFCRNYFNILDLLVVSVSLISF------GIQSSAI------NVVKILRVLRVLR 1001

Query: 555  FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGN 611
             LR I   K +  V   V   +   R  G I++V   + ++FA IG+ LF+G +     +
Sbjct: 1002 PLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1058

Query: 612  SSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
            S    A       +++         Q   W N   +FD+  AA++ L+ +     W   L
Sbjct: 1059 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1118

Query: 660  ----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
                D++    GP         I+F+++ ++ +   +N+F+  ++  F
Sbjct: 1119 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1166



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 126/693 (18%), Positives = 279/693 (40%), Gaps = 183/693 (26%)

Query: 82   CQRTLSFTIFLILFLAFIETPS-SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
            C R ++ TIF  L L FI   S SL +   V++ +        +    +++   +F  ++
Sbjct: 890  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH----ILFYFDIVFTTIFTIEI 945

Query: 141  SVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFL 195
            ++K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+LRP   
Sbjct: 946  ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRA 1005

Query: 196  LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------GKQDDGQ 247
            +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         KQ + +
Sbjct: 1006 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1065

Query: 248  DRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
             +   +TY                     F N+  ++ +L  + T    P+++       
Sbjct: 1066 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1125

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P Y+     +IFFI++ +I + F+MN+        F G+++ + Q          
Sbjct: 1126 TEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-------- 1169

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                       GE                Q  +  +LD + +Q +   +++         
Sbjct: 1170 -----------GE----------------QEYKNCELDKNQRQCVEYALKA--------- 1193

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI----- 449
                         ++ + P+ ++Q        ++    YF+YL  ++ L N + +     
Sbjct: 1194 -----------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1238

Query: 450  ---CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG 506
               C+F +              + ILN +F   + +EM+LK+ A   +GY S P NVFD 
Sbjct: 1239 GQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDF 1285

Query: 507  LL---TVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMK 563
            L+   +++ ++L  +  A +    P    E    +S+        +  V R ++++   +
Sbjct: 1286 LIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISI----TFFRLFRVMRLVKLLSRGE 1341

Query: 564  LMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPC 623
             +  +  T +   Q +     ++V++++++A+IG+ +F  + +     +     N +   
Sbjct: 1342 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL-----NDTTEINRN--- 1393

Query: 624  GSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------------------DAYRR 664
                      NNF  F  A++ L+       WQ  +                   +    
Sbjct: 1394 ----------NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETP 1443

Query: 665  YSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
                ++  YF+ ++++ + + +NLF+A+I++NF
Sbjct: 1444 CGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1476



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 131/650 (20%), Positives = 259/650 (39%), Gaps = 136/650 (20%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAG------------GKQDD----------------------GQD--RER 251
            ++ + G+ LF G              +DD                      G D  +  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIAAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHG 339

Query: 252 LTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNL 306
           +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F++NL
Sbjct: 340 ITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFVLNL 396

Query: 307 LTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVL 366
           +  ++  +F     K+     F++    R   ++   + G      QA  + P+N  + +
Sbjct: 397 VLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENEDEGM 453

Query: 367 -QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFL 422
            ++   + S   +  E V +    G  +       +L + + +S    +  R  +     
Sbjct: 454 DEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNRFCR 511

Query: 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLL 482
           +  +       F +L   +   N ++I        + L   +D       N   +  +  
Sbjct: 512 RKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLALFTA 566

Query: 483 EMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRPEMV 535
           EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L         V
Sbjct: 567 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL-------RCV 619

Query: 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY---YV 592
            LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++    +
Sbjct: 620 RLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLFIII 661

Query: 593 FAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV 652
           F+++G+ LF G                     +F++++   + FD+F  +L+T++ ++  
Sbjct: 662 FSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQILTG 702

Query: 653 NNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
            +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 EDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 752



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 70/293 (23%), Positives = 130/293 (44%), Gaps = 42/293 (14%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G + 
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 607 ALPGN-SSLAPANGSAPCG-----------------SFEQLEYWANNFDDFAAALVTLWN 648
               N   +A  +  +PC                   ++  ++   NFD+FA A++T++ 
Sbjct: 296 KTCYNQEGIAAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQ 355

Query: 649 LMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
            + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 CITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 405


>gi|193788540 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 16 [Homo sapiens]
          Length = 2138

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 161/708 (22%), Positives = 293/708 (41%), Gaps = 107/708 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + IL   + VF   + +E+ LK+ A G  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYG-- 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
             +L   S   +    + LLV+ +S ++       G +   +      ++ ++L +L V R
Sbjct: 957  AFLHKGSFCRNYFNILDLLVVSVSLISF------GIQSSAI------NVVKILRVLRVLR 1004

Query: 555  FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGN 611
             LR I   K +  V   V   +   R  G I++V   + ++FA IG+ LF+G +     +
Sbjct: 1005 PLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061

Query: 612  SSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
            S    A       +++         Q   W N   +FD+  AA++ L+ +     W   L
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121

Query: 660  ----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
                D++    GP         I+F+++ ++ +   +N+F+  ++  F
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 126/693 (18%), Positives = 279/693 (40%), Gaps = 183/693 (26%)

Query: 82   CQRTLSFTIFLILFLAFIETPS-SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
            C R ++ TIF  L L FI   S SL +   V++ +        +    +++   +F  ++
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH----ILFYFDIVFTTIFTIEI 948

Query: 141  SVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFL 195
            ++K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+LRP   
Sbjct: 949  ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 196  LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------GKQDDGQ 247
            +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         KQ + +
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 248  DRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
             +   +TY                     F N+  ++ +L  + T    P+++       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P Y+     +IFFI++ +I + F+MN+        F G+++ + Q          
Sbjct: 1129 TEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-------- 1172

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                       GE                Q  +  +LD + +Q +   +++         
Sbjct: 1173 -----------GE----------------QEYKNCELDKNQRQCVEYALKA--------- 1196

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI----- 449
                         ++ + P+ ++Q        ++    YF+YL  ++ L N + +     
Sbjct: 1197 -----------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1241

Query: 450  ---CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG 506
               C+F +              + ILN +F   + +EM+LK+ A   +GY S P NVFD 
Sbjct: 1242 GQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDF 1288

Query: 507  LL---TVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMK 563
            L+   +++ ++L  +  A +    P    E    +S+        +  V R ++++   +
Sbjct: 1289 LIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISI----TFFRLFRVMRLVKLLSRGE 1344

Query: 564  LMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPC 623
             +  +  T +   Q +     ++V++++++A+IG+ +F  + +     +     N +   
Sbjct: 1345 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL-----NDTTEINRN--- 1396

Query: 624  GSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------------------DAYRR 664
                      NNF  F  A++ L+       WQ  +                   +    
Sbjct: 1397 ----------NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETP 1446

Query: 665  YSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
                ++  YF+ ++++ + + +NLF+A+I++NF
Sbjct: 1447 CGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 131/653 (20%), Positives = 259/653 (39%), Gaps = 139/653 (21%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAGGK---------------QDD----------------------GQD-- 248
            ++ + G+ LF G                 +DD                      G D  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339

Query: 249 RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
           +  +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F+
Sbjct: 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396

Query: 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
           +NL+  ++  +F     K+     F++    R   ++   + G      QA  + P+N  
Sbjct: 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453

Query: 364 QVL-QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
           + + ++   + S   +  E V +    G  +       +L + + +S    +  R  +  
Sbjct: 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511

Query: 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
              +  +       F +L   +   N ++I        + L   +D       N   +  
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566

Query: 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
           +  EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L       
Sbjct: 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619

Query: 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY-- 590
             V LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++  
Sbjct: 620 RCVRLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLF 661

Query: 591 -YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
             +F+++G+ LF G                     +F++++   + FD+F  +L+T++ +
Sbjct: 662 IIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQI 702

Query: 650 MVVNNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
           +   +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 45/296 (15%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408


>gi|193794832 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoforom 13 [Homo sapiens]
          Length = 2144

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 161/708 (22%), Positives = 293/708 (41%), Gaps = 107/708 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + IL   + VF   + +E+ LK+ A G  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYG-- 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
             +L   S   +    + LLV+ +S ++       G +   +      ++ ++L +L V R
Sbjct: 957  AFLHKGSFCRNYFNILDLLVVSVSLISF------GIQSSAI------NVVKILRVLRVLR 1004

Query: 555  FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGN 611
             LR I   K +  V   V   +   R  G I++V   + ++FA IG+ LF+G +     +
Sbjct: 1005 PLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061

Query: 612  SSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
            S    A       +++         Q   W N   +FD+  AA++ L+ +     W   L
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121

Query: 660  ----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
                D++    GP         I+F+++ ++ +   +N+F+  ++  F
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 131/653 (20%), Positives = 259/653 (39%), Gaps = 139/653 (21%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAGGK---------------QDD----------------------GQD-- 248
            ++ + G+ LF G                 +DD                      G D  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339

Query: 249 RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
           +  +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F+
Sbjct: 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396

Query: 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
           +NL+  ++  +F     K+     F++    R   ++   + G      QA  + P+N  
Sbjct: 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453

Query: 364 QVL-QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
           + + ++   + S   +  E V +    G  +       +L + + +S    +  R  +  
Sbjct: 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511

Query: 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
              +  +       F +L   +   N ++I        + L   +D       N   +  
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566

Query: 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
           +  EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L       
Sbjct: 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619

Query: 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY-- 590
             V LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++  
Sbjct: 620 RCVRLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLF 661

Query: 591 -YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
             +F+++G+ LF G                     +F++++   + FD+F  +L+T++ +
Sbjct: 662 IIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQI 702

Query: 650 MVVNNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
           +   +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 121/690 (17%), Positives = 269/690 (38%), Gaps = 190/690 (27%)

Query: 82   CQRTLSFTIFLILFLAFIETPS-SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
            C R ++ TIF  L L FI   S SL +   V++ +        +    +++   +F  ++
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH----ILFYFDIVFTTIFTIEI 948

Query: 141  SVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFL 195
            ++K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+LRP   
Sbjct: 949  ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 196  LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------GKQDDGQ 247
            +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         KQ + +
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 248  DRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
             +   +TY                     F N+  ++ +L  + T    P+++       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P Y+     +IFFI++ +I + F+MN+        F G+++ + Q          
Sbjct: 1129 TEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-------- 1172

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                       GE                Q  +  +LD + +Q +   +++         
Sbjct: 1173 -----------GE----------------QEYKNCELDKNQRQCVEYALKA--------- 1196

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI----- 449
                         ++ + P+ ++Q        ++    YF+YL  ++ L N + +     
Sbjct: 1197 -----------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1241

Query: 450  ---CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG 506
               C+F +              + ILN +F   + +EM+LK+ A   + Y     N FD 
Sbjct: 1242 GQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDA 1288

Query: 507  LLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMA 566
            L+ V  +V     +A+        R  +              +  V R ++++   + + 
Sbjct: 1289 LIVVGSIV----DIAITENAEENSRISIT----------FFRLFRVMRLVKLLSRGEGIR 1334

Query: 567  VVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSF 626
             +  T +   Q +     ++V++++++A+IG+ +F  + +     +     N +      
Sbjct: 1335 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL-----NDTTEINRN------ 1383

Query: 627  EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------------------DAYRRYSG 667
                   NNF  F  A++ L+       WQ  +                   +       
Sbjct: 1384 -------NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS 1436

Query: 668  PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
             ++  YF+ ++++ + + +NLF+A+I++NF
Sbjct: 1437 SFAVFYFISFYMLCAFLIINLFVAVIMDNF 1466



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 45/296 (15%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408


>gi|193788532 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 11 [Homo sapiens]
          Length = 2146

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 161/708 (22%), Positives = 293/708 (41%), Gaps = 107/708 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + IL   + VF   + +E+ LK+ A G  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYG-- 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
             +L   S   +    + LLV+ +S ++       G +   +      ++ ++L +L V R
Sbjct: 957  AFLHKGSFCRNYFNILDLLVVSVSLISF------GIQSSAI------NVVKILRVLRVLR 1004

Query: 555  FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGN 611
             LR I   K +  V   V   +   R  G I++V   + ++FA IG+ LF+G +     +
Sbjct: 1005 PLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061

Query: 612  SSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
            S    A       +++         Q   W N   +FD+  AA++ L+ +     W   L
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121

Query: 660  ----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
                D++    GP         I+F+++ ++ +   +N+F+  ++  F
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 131/653 (20%), Positives = 259/653 (39%), Gaps = 139/653 (21%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAGGK---------------QDD----------------------GQD-- 248
            ++ + G+ LF G                 +DD                      G D  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339

Query: 249 RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
           +  +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F+
Sbjct: 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396

Query: 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
           +NL+  ++  +F     K+     F++    R   ++   + G      QA  + P+N  
Sbjct: 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453

Query: 364 QVL-QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
           + + ++   + S   +  E V +    G  +       +L + + +S    +  R  +  
Sbjct: 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511

Query: 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
              +  +       F +L   +   N ++I        + L   +D       N   +  
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566

Query: 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
           +  EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L       
Sbjct: 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619

Query: 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY-- 590
             V LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++  
Sbjct: 620 RCVRLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLF 661

Query: 591 -YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
             +F+++G+ LF G                     +F++++   + FD+F  +L+T++ +
Sbjct: 662 IIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQI 702

Query: 650 MVVNNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
           +   +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 123/690 (17%), Positives = 273/690 (39%), Gaps = 188/690 (27%)

Query: 82   CQRTLSFTIFLILFLAFIETPS-SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
            C R ++ TIF  L L FI   S SL +   V++ +        +    +++   +F  ++
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH----ILFYFDIVFTTIFTIEI 948

Query: 141  SVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFL 195
            ++K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+LRP   
Sbjct: 949  ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 196  LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------GKQDDGQ 247
            +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         KQ + +
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 248  DRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
             +   +TY                     F N+  ++ +L  + T    P+++       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P Y+     +IFFI++ +I + F+MN+        F G+++ + Q          
Sbjct: 1129 TEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-------- 1172

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                       GE                Q  +  +LD + +Q +   +++         
Sbjct: 1173 -----------GE----------------QEYKNCELDKNQRQCVEYALKA--------- 1196

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI----- 449
                         ++ + P+ ++Q        ++    YF+YL  ++ L N + +     
Sbjct: 1197 -----------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1241

Query: 450  ---CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG 506
               C+F +              + ILN +F   + +EM+LK+ A   + Y     N FD 
Sbjct: 1242 GQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDA 1288

Query: 507  LLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMA 566
            L+ VV  +++I+   V          E    +S+        +  V R ++++   + + 
Sbjct: 1289 LI-VVGSIVDIAITEVN-------NAEENSRISI----TFFRLFRVMRLVKLLSRGEGIR 1336

Query: 567  VVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSF 626
             +  T +   Q +     ++V++++++A+IG+ +F  + +     +     N +      
Sbjct: 1337 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL-----NDTTEINRN------ 1385

Query: 627  EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------------------DAYRRYSG 667
                   NNF  F  A++ L+       WQ  +                   +       
Sbjct: 1386 -------NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS 1438

Query: 668  PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
             ++  YF+ ++++ + + +NLF+A+I++NF
Sbjct: 1439 SFAVFYFISFYMLCAFLIINLFVAVIMDNF 1468



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 45/296 (15%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408


>gi|193788528 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 8 [Homo sapiens]
          Length = 2157

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 161/708 (22%), Positives = 293/708 (41%), Gaps = 107/708 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + IL   + VF   + +E+ LK+ A G  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYG-- 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
             +L   S   +    + LLV+ +S ++       G +   +      ++ ++L +L V R
Sbjct: 957  AFLHKGSFCRNYFNILDLLVVSVSLISF------GIQSSAI------NVVKILRVLRVLR 1004

Query: 555  FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGN 611
             LR I   K +  V   V   +   R  G I++V   + ++FA IG+ LF+G +     +
Sbjct: 1005 PLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061

Query: 612  SSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
            S    A       +++         Q   W N   +FD+  AA++ L+ +     W   L
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121

Query: 660  ----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
                D++    GP         I+F+++ ++ +   +N+F+  ++  F
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 124/690 (17%), Positives = 273/690 (39%), Gaps = 177/690 (25%)

Query: 82   CQRTLSFTIFLILFLAFIETPS-SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
            C R ++ TIF  L L FI   S SL +   V++ +        +    +++   +F  ++
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH----ILFYFDIVFTTIFTIEI 948

Query: 141  SVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFL 195
            ++K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+LRP   
Sbjct: 949  ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 196  LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------GKQDDGQ 247
            +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         KQ + +
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 248  DRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
             +   +TY                     F N+  ++ +L  + T    P+++       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P Y+     +IFFI++ +I + F+MN+        F G+++ + Q          
Sbjct: 1129 TEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-------- 1172

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                       GE                Q  +  +LD + +Q +   +++         
Sbjct: 1173 -----------GE----------------QEYKNCELDKNQRQCVEYALKA--------- 1196

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI----- 449
                         ++ + P+ ++Q        ++    YF+YL  ++ L N + +     
Sbjct: 1197 -----------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1241

Query: 450  ---CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG 506
               C+F +              + ILN +F   + +EM+LK+ A   + Y     N FD 
Sbjct: 1242 GQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDA 1288

Query: 507  LLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMA 566
            L+ VV  +++I+   V    H    P M    +         +  V R ++++   + + 
Sbjct: 1289 LI-VVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIR 1347

Query: 567  VVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSF 626
             +  T +   Q +     ++V++++++A+IG+ +F  + +     +     N +      
Sbjct: 1348 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL-----NDTTEINRN------ 1396

Query: 627  EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------------------DAYRRYSG 667
                   NNF  F  A++ L+       WQ  +                   +       
Sbjct: 1397 -------NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS 1449

Query: 668  PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
             ++  YF+ ++++ + + +NLF+A+I++NF
Sbjct: 1450 SFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 131/653 (20%), Positives = 259/653 (39%), Gaps = 139/653 (21%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAGGK---------------QDD----------------------GQD-- 248
            ++ + G+ LF G                 +DD                      G D  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339

Query: 249 RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
           +  +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F+
Sbjct: 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396

Query: 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
           +NL+  ++  +F     K+     F++    R   ++   + G      QA  + P+N  
Sbjct: 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453

Query: 364 QVL-QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
           + + ++   + S   +  E V +    G  +       +L + + +S    +  R  +  
Sbjct: 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511

Query: 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
              +  +       F +L   +   N ++I        + L   +D       N   +  
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566

Query: 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
           +  EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L       
Sbjct: 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619

Query: 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY-- 590
             V LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++  
Sbjct: 620 RCVRLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLF 661

Query: 591 -YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
             +F+++G+ LF G                     +F++++   + FD+F  +L+T++ +
Sbjct: 662 IIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQI 702

Query: 650 MVVNNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
           +   +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 45/296 (15%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408


>gi|193794828 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 7 [Homo sapiens]
          Length = 2157

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 161/708 (22%), Positives = 293/708 (41%), Gaps = 107/708 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + IL   + VF   + +E+ LK+ A G  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYG-- 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
             +L   S   +    + LLV+ +S ++       G +   +      ++ ++L +L V R
Sbjct: 957  AFLHKGSFCRNYFNILDLLVVSVSLISF------GIQSSAI------NVVKILRVLRVLR 1004

Query: 555  FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGN 611
             LR I   K +  V   V   +   R  G I++V   + ++FA IG+ LF+G +     +
Sbjct: 1005 PLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061

Query: 612  SSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
            S    A       +++         Q   W N   +FD+  AA++ L+ +     W   L
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121

Query: 660  ----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
                D++    GP         I+F+++ ++ +   +N+F+  ++  F
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF 1169



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 126/693 (18%), Positives = 279/693 (40%), Gaps = 183/693 (26%)

Query: 82   CQRTLSFTIFLILFLAFIETPS-SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
            C R ++ TIF  L L FI   S SL +   V++ +        +    +++   +F  ++
Sbjct: 893  CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH----ILFYFDIVFTTIFTIEI 948

Query: 141  SVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFL 195
            ++K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+LRP   
Sbjct: 949  ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRA 1008

Query: 196  LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------GKQDDGQ 247
            +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         KQ + +
Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068

Query: 248  DRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
             +   +TY                     F N+  ++ +L  + T    P+++       
Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P Y+     +IFFI++ +I + F+MN+        F G+++ + Q          
Sbjct: 1129 TEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-------- 1172

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                       GE                Q  +  +LD + +Q +   +++         
Sbjct: 1173 -----------GE----------------QEYKNCELDKNQRQCVEYALKA--------- 1196

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI----- 449
                         ++ + P+ ++Q        ++    YF+YL  ++ L N + +     
Sbjct: 1197 -----------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTICLAMQHY 1241

Query: 450  ---CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG 506
               C+F +              + ILN +F   + +EM+LK+ A   +GY S P NVFD 
Sbjct: 1242 GQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDF 1288

Query: 507  LL---TVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMK 563
            L+   +++ ++L  +  A +    P    E    +S+        +  V R ++++   +
Sbjct: 1289 LIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISI----TFFRLFRVMRLVKLLSRGE 1344

Query: 564  LMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPC 623
             +  +  T +   Q +     ++V++++++A+IG+ +F  + +     +     N +   
Sbjct: 1345 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL-----NDTTEINRN--- 1396

Query: 624  GSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------------------DAYRR 664
                      NNF  F  A++ L+       WQ  +                   +    
Sbjct: 1397 ----------NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETP 1446

Query: 665  YSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
                ++  YF+ ++++ + + +NLF+A+I++NF
Sbjct: 1447 CGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 131/653 (20%), Positives = 259/653 (39%), Gaps = 139/653 (21%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAGGK---------------QDD----------------------GQD-- 248
            ++ + G+ LF G                 +DD                      G D  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339

Query: 249 RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
           +  +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F+
Sbjct: 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396

Query: 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
           +NL+  ++  +F     K+     F++    R   ++   + G      QA  + P+N  
Sbjct: 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453

Query: 364 QVL-QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
           + + ++   + S   +  E V +    G  +       +L + + +S    +  R  +  
Sbjct: 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511

Query: 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
              +  +       F +L   +   N ++I        + L   +D       N   +  
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566

Query: 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
           +  EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L       
Sbjct: 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619

Query: 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY-- 590
             V LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++  
Sbjct: 620 RCVRLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLF 661

Query: 591 -YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
             +F+++G+ LF G                     +F++++   + FD+F  +L+T++ +
Sbjct: 662 IIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQI 702

Query: 650 MVVNNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
           +   +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 45/296 (15%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408


>gi|193788724 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 2 [Homo sapiens]
          Length = 2186

 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 159/722 (22%), Positives = 297/722 (41%), Gaps = 115/722 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + IL   + VF   + +E+ LK+  LG  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKI--LGNA 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPG-----------WRPEMVGLLSLWDM 543
             Y      VF  + T+  ++L+++    +   H G                V L+S    
Sbjct: 957  DY------VFTSIFTLE-IILKMTAYGAFL--HKGSFCRNYFNILDLLVVSVSLISFGIQ 1007

Query: 544  TRMLNMLIVFRFLRIIPSMKLM---AVVASTVLGLVQNMRAFGGILVV---VYYVFAIIG 597
            +  +N++ + R LR++  ++ +     +   V  +   +R  G I++V   + ++FA IG
Sbjct: 1008 SSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIG 1067

Query: 598  INLFRGVIVALPGNSSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVT 645
            + LF+G +     +S    A       +++         Q   W N   +FD+  AA++ 
Sbjct: 1068 VQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMA 1127

Query: 646  LWNLMVVNNWQVFL----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILE 695
            L+ +     W   L    D++    GP         I+F+++ ++ +   +N+F+  ++ 
Sbjct: 1128 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1187

Query: 696  NF 697
             F
Sbjct: 1188 TF 1189



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 131/653 (20%), Positives = 259/653 (39%), Gaps = 139/653 (21%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAGGK---------------QDD----------------------GQD-- 248
            ++ + G+ LF G                 +DD                      G D  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339

Query: 249 RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
           +  +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F+
Sbjct: 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396

Query: 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
           +NL+  ++  +F     K+     F++    R   ++   + G      QA  + P+N  
Sbjct: 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453

Query: 364 QVL-QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
           + + ++   + S   +  E V +    G  +       +L + + +S    +  R  +  
Sbjct: 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511

Query: 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
              +  +       F +L   +   N ++I        + L   +D       N   +  
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566

Query: 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
           +  EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L       
Sbjct: 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619

Query: 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY-- 590
             V LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++  
Sbjct: 620 RCVRLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLF 661

Query: 591 -YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
             +F+++G+ LF G                     +F++++   + FD+F  +L+T++ +
Sbjct: 662 IIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQI 702

Query: 650 MVVNNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
           +   +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 116/663 (17%), Positives = 253/663 (38%), Gaps = 198/663 (29%)

Query: 135  VFAADLSVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRL 189
            +F  ++ +K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+
Sbjct: 963  IFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRV 1022

Query: 190  LRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------G 241
            LRP   +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         
Sbjct: 1023 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSS 1082

Query: 242  KQDDGQDRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI 279
            KQ + + +   +TY                     F N+  ++ +L  + T    P+++ 
Sbjct: 1083 KQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLY 1142

Query: 280  -----------PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLF 328
                       P Y+     +IFFI++ +I + F+MN+        F G+++ + Q    
Sbjct: 1143 RSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-- 1192

Query: 329  RRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGS 388
                             GE                Q  +  +LD + +Q +   +++   
Sbjct: 1193 -----------------GE----------------QEYKNCELDKNQRQCVEYALKA--- 1216

Query: 389  VLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVS 448
                               ++ + P+ ++Q        ++    YF+YL  ++ L N + 
Sbjct: 1217 -----------------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTIC 1255

Query: 449  I--------CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP 500
            +        C+F +              + ILN +F   + +EM+LK+ A   +GY S P
Sbjct: 1256 LAMQHYGQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKGYFSDP 1302

Query: 501  SNVFDGL---------------------------LTVVLLVLEISTLAVYRLPHPGWRPE 533
             NVFD L                           L VV  +++I+   V    H    P 
Sbjct: 1303 WNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPS 1362

Query: 534  MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVF 593
            M    +         +  V R ++++   + +  +  T +   Q +     ++V++++++
Sbjct: 1363 MNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 1422

Query: 594  AIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVN 653
            A+IG+ +F  + +     +     N +             NNF  F  A++ L+      
Sbjct: 1423 AVIGMQVFGKIAL-----NDTTEINRN-------------NNFQTFPQAVLLLFRCATGE 1464

Query: 654  NWQVFL-------------------DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
             WQ  +                   +        ++  YF+ ++++ + + +NLF+A+I+
Sbjct: 1465 AWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIM 1524

Query: 695  ENF 697
            +NF
Sbjct: 1525 DNF 1527



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 45/296 (15%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408


>gi|193788720 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 1 [Homo sapiens]
          Length = 2221

 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 159/722 (22%), Positives = 297/722 (41%), Gaps = 115/722 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + IL   + VF   + +E+ LK+  LG  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKI--LGNA 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPG-----------WRPEMVGLLSLWDM 543
             Y      VF  + T+  ++L+++    +   H G                V L+S    
Sbjct: 957  DY------VFTSIFTLE-IILKMTAYGAFL--HKGSFCRNYFNILDLLVVSVSLISFGIQ 1007

Query: 544  TRMLNMLIVFRFLRIIPSMKLM---AVVASTVLGLVQNMRAFGGILVV---VYYVFAIIG 597
            +  +N++ + R LR++  ++ +     +   V  +   +R  G I++V   + ++FA IG
Sbjct: 1008 SSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIG 1067

Query: 598  INLFRGVIVALPGNSSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVT 645
            + LF+G +     +S    A       +++         Q   W N   +FD+  AA++ 
Sbjct: 1068 VQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMA 1127

Query: 646  LWNLMVVNNWQVFL----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILE 695
            L+ +     W   L    D++    GP         I+F+++ ++ +   +N+F+  ++ 
Sbjct: 1128 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1187

Query: 696  NF 697
             F
Sbjct: 1188 TF 1189



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 131/653 (20%), Positives = 259/653 (39%), Gaps = 139/653 (21%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAGGK---------------QDD----------------------GQD-- 248
            ++ + G+ LF G                 +DD                      G D  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339

Query: 249 RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
           +  +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F+
Sbjct: 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396

Query: 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
           +NL+  ++  +F     K+     F++    R   ++   + G      QA  + P+N  
Sbjct: 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453

Query: 364 QVL-QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
           + + ++   + S   +  E V +    G  +       +L + + +S    +  R  +  
Sbjct: 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511

Query: 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
              +  +       F +L   +   N ++I        + L   +D       N   +  
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566

Query: 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
           +  EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L       
Sbjct: 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619

Query: 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY-- 590
             V LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++  
Sbjct: 620 RCVRLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLF 661

Query: 591 -YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
             +F+++G+ LF G                     +F++++   + FD+F  +L+T++ +
Sbjct: 662 IIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQI 702

Query: 650 MVVNNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
           +   +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 116/663 (17%), Positives = 253/663 (38%), Gaps = 198/663 (29%)

Query: 135  VFAADLSVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRL 189
            +F  ++ +K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+
Sbjct: 963  IFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRV 1022

Query: 190  LRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------G 241
            LRP   +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         
Sbjct: 1023 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSS 1082

Query: 242  KQDDGQDRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI 279
            KQ + + +   +TY                     F N+  ++ +L  + T    P+++ 
Sbjct: 1083 KQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLY 1142

Query: 280  -----------PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLF 328
                       P Y+     +IFFI++ +I + F+MN+        F G+++ + Q    
Sbjct: 1143 RSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-- 1192

Query: 329  RRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGS 388
                             GE                Q  +  +LD + +Q +   +++   
Sbjct: 1193 -----------------GE----------------QEYKNCELDKNQRQCVEYALKA--- 1216

Query: 389  VLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVS 448
                               ++ + P+ ++Q        ++    YF+YL  ++ L N + 
Sbjct: 1217 -----------------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTIC 1255

Query: 449  I--------CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP 500
            +        C+F +              + ILN +F   + +EM+LK+ A   +GY S P
Sbjct: 1256 LAMQHYGQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKGYFSDP 1302

Query: 501  SNVFDGL---------------------------LTVVLLVLEISTLAVYRLPHPGWRPE 533
             NVFD L                           L VV  +++I+   V    H    P 
Sbjct: 1303 WNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPS 1362

Query: 534  MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVF 593
            M    +         +  V R ++++   + +  +  T +   Q +     ++V++++++
Sbjct: 1363 MNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIY 1422

Query: 594  AIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVN 653
            A+IG+ +F  + +     +     N +             NNF  F  A++ L+      
Sbjct: 1423 AVIGMQVFGKIAL-----NDTTEINRN-------------NNFQTFPQAVLLLFRCATGE 1464

Query: 654  NWQVFL-------------------DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
             WQ  +                   +        ++  YF+ ++++ + + +NLF+A+I+
Sbjct: 1465 AWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIM 1524

Query: 695  ENF 697
            +NF
Sbjct: 1525 DNF 1527



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 45/296 (15%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408


>gi|193788526 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 6 [Homo sapiens]
          Length = 2158

 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 159/722 (22%), Positives = 297/722 (41%), Gaps = 115/722 (15%)

Query: 64   HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
            HR+  S    Y R ++  C+R     +      +L++FL F+ T     + A   Y    
Sbjct: 495  HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550

Query: 118  WEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVV---LVVSLVDWT 173
            W      T +  +L L  F A++ +K Y  G  A+F          VV   ++ +++  T
Sbjct: 551  WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608

Query: 174  VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
              +S +    LR  RLLR F + +  + +   +  +  S+  +AS+ LLL + + +F++ 
Sbjct: 609  KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668

Query: 234  GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYS----KNR 286
            GM LF GGK +  + + R + F N P+SL ++  +LT  +   VM   I AY        
Sbjct: 669  GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGM 727

Query: 287  AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG-----YLMKSLQTSLFRRRLGTRAAFEVL 341
               I+FI+  + G+  L+N+  AI               K  +    R++L   A+ E  
Sbjct: 728  LVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 787

Query: 342  SSMVGEGGAFPQAVGVKPQNLLQV-----------LQKVQLDSSHKQAMMEKVRSYGSVL 390
              +V +      AVG   +  +++             K+ +D        +K   Y +  
Sbjct: 788  QELVEK-----PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDK-SPYPNPE 841

Query: 391  LSAEEFQK--------LFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
             + EE ++            L    +KE   P PE  + F+ S+   F       + + I
Sbjct: 842  TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901

Query: 442  ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGLR 494
               NL  I  F++L +  L AE         + IL   + VF   + +E+ LK+  LG  
Sbjct: 902  -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKI--LGNA 956

Query: 495  GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPG-----------WRPEMVGLLSLWDM 543
             Y      VF  + T+  ++L+++    +   H G                V L+S    
Sbjct: 957  DY------VFTSIFTLE-IILKMTAYGAFL--HKGSFCRNYFNILDLLVVSVSLISFGIQ 1007

Query: 544  TRMLNMLIVFRFLRIIPSMKLM---AVVASTVLGLVQNMRAFGGILVV---VYYVFAIIG 597
            +  +N++ + R LR++  ++ +     +   V  +   +R  G I++V   + ++FA IG
Sbjct: 1008 SSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIG 1067

Query: 598  INLFRGVIVALPGNSSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVT 645
            + LF+G +     +S    A       +++         Q   W N   +FD+  AA++ 
Sbjct: 1068 VQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMA 1127

Query: 646  LWNLMVVNNWQVFL----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILE 695
            L+ +     W   L    D++    GP         I+F+++ ++ +   +N+F+  ++ 
Sbjct: 1128 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1187

Query: 696  NF 697
             F
Sbjct: 1188 TF 1189



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 131/653 (20%), Positives = 259/653 (39%), Gaps = 139/653 (21%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
           E VE L L++F  +  +K    G LF    + +N W L   +++VV L    +  +    
Sbjct: 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219

Query: 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
                         + LR  R+LRP  L+     ++  L  I  ++  +  + LL+   +
Sbjct: 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279

Query: 228 CLFTMFGMLLFAGGK---------------QDD----------------------GQD-- 248
            ++ + G+ LF G                 +DD                      G D  
Sbjct: 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339

Query: 249 RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
           +  +T F N   ++ ++   +T     DV+   Y  N A       I+F+   +IGS F+
Sbjct: 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396

Query: 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
           +NL+  ++  +F     K+     F++    R   ++   + G      QA  + P+N  
Sbjct: 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453

Query: 364 QVL-QKVQLDSSHKQAMMEKVRS---YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
           + + ++   + S   +  E V +    G  +       +L + + +S    +  R  +  
Sbjct: 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511

Query: 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
              +  +       F +L   +   N ++I        + L   +D       N   +  
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566

Query: 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
           +  EMLLK+++LGL+ Y     N FD      G+L  +L+  +I S L +  L       
Sbjct: 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619

Query: 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY-- 590
             V LL ++ +TR  N L                  ++ V  L+ ++R+   +L++++  
Sbjct: 620 RCVRLLRIFKITRYWNSL------------------SNLVASLLNSVRSIASLLLLLFLF 661

Query: 591 -YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
             +F+++G+ LF G                     +F++++   + FD+F  +L+T++ +
Sbjct: 662 IIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQI 702

Query: 650 MVVNNW-QVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
           +   +W  V  D    Y GP        IYF++ ++  + I +N+FLA+ ++N
Sbjct: 703 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 111/636 (17%), Positives = 249/636 (39%), Gaps = 172/636 (27%)

Query: 135  VFAADLSVKGYLFG-WAH---FQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRL 189
            +F  ++ +K   +G + H   F +N + +  L+V+ VSL+ + +  S +   + LR+ R+
Sbjct: 963  IFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRV 1022

Query: 190  LRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------G 241
            LRP   +  +  +K  ++C+  ++  + ++ ++  +   +F   G+ LF G         
Sbjct: 1023 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSS 1082

Query: 242  KQDDGQDRER-LTY---------------------FQNLPESLTSLLVLLTTANNPDVMI 279
            KQ + + +   +TY                     F N+  ++ +L  + T    P+++ 
Sbjct: 1083 KQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLY 1142

Query: 280  -----------PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLF 328
                       P Y+     +IFFI++ +I + F+MN+        F G+++ + Q    
Sbjct: 1143 RSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI--------FVGFVIVTFQEQ-- 1192

Query: 329  RRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGS 388
                             GE                Q  +  +LD + +Q +   +++   
Sbjct: 1193 -----------------GE----------------QEYKNCELDKNQRQCVEYALKA--- 1216

Query: 389  VLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVS 448
                               ++ + P+ ++Q        ++    YF+YL  ++ L N + 
Sbjct: 1217 -----------------RPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLILLNTIC 1255

Query: 449  I--------CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP 500
            +        C+F +              + ILN +F   + +EM+LK+ A   + Y    
Sbjct: 1256 LAMQHYGQSCLFKIA-------------MNILNMLFTGLFTVEMILKLIAFKPKHYFCDA 1302

Query: 501  SNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIP 560
             N FD L+ VV  +++I+   V    H    P M    +         +  V R ++++ 
Sbjct: 1303 WNTFDALI-VVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLS 1361

Query: 561  SMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGS 620
              + +  +  T +   Q +     ++V++++++A+IG+ +F  + +     +     N +
Sbjct: 1362 RGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL-----NDTTEINRN 1416

Query: 621  APCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------------------DA 661
                         NNF  F  A++ L+       WQ  +                   + 
Sbjct: 1417 -------------NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEG 1463

Query: 662  YRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
                   ++  YF+ ++++ + + +NLF+A+I++NF
Sbjct: 1464 ETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1499



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 45/296 (15%)

Query: 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
           F+ +  L   AN V++ +++    D   A   +  L  +  +F++ + +E  LKV A GL
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGL 183

Query: 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
                 YL    N+ D ++ VV L   +LE +T A            + G  + +D+ + 
Sbjct: 184 LFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KA 235

Query: 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-- 604
           L    V R LR++  +  + VV ++++  +  +     +++ V  ++AIIG+ LF G   
Sbjct: 236 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMH 295

Query: 605 --------IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVT 645
                   I  +P     +P            NG+     ++  ++   NFD+FA A++T
Sbjct: 296 KTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLT 355

Query: 646 LWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
           ++  + +  W   L    DA  R    W  IYFV   ++ S   +NL L ++   F
Sbjct: 356 VFQCITMEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408


>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform b [Homo sapiens]
          Length = 2347

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 80/301 (26%), Positives = 138/301 (45%), Gaps = 38/301 (12%)

Query: 418  QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDA-DVLPAERDDFILGILNCVF 476
            Q+ F  S Q +  H  FD++  +    N    CV + L+  D+ P   +   L + N +F
Sbjct: 1280 QNRFRVSCQKVITHKMFDHVVLVFIFLN----CVTIALERPDIDPGSTERVFLSVSNYIF 1335

Query: 477  IVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
               ++ EM++KV ALGL      YL    N+ DGLL +V LV  +  +A           
Sbjct: 1336 TAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMA----------- 1384

Query: 533  EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV--- 589
               G   +  + R+L +L   R LR+I     + +V  T   L+ ++R  G I+++    
Sbjct: 1385 -SAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVET---LISSLRPIGNIVLICCAF 1440

Query: 590  YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
            + +F I+G+ LF+G      G  +   +  +    +  +      NFD+   AL++L+ L
Sbjct: 1441 FIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVL 1500

Query: 650  MVVNNWQVF----LDAYR------RYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
               + W       LDA        +   PW  +YF+ + L+ S   +N+F+ +++ENF H
Sbjct: 1501 SSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF-H 1559

Query: 700  K 700
            K
Sbjct: 1560 K 1560



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 66/234 (28%), Positives = 109/234 (46%), Gaps = 35/234 (14%)

Query: 469  LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
            L I N VF   + LEMLLK+ A G  GY+  P N+FDG++ VV+ V EI   A       
Sbjct: 825  LEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGII-VVISVWEIVGQA------- 876

Query: 529  GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
                   G LS+    R+L +L + RFL   P+++   VV   ++  + N+  F  +L++
Sbjct: 877  ------DGGLSVLRTFRLLRVLKLVRFL---PALRRQLVV---LVKTMDNVATFCTLLML 924

Query: 589  VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWN 648
              ++F+I+G++LF              P                  NFD    A+VT++ 
Sbjct: 925  FIFIFSILGMHLFGCKFSLKTDTGDTVPDR---------------KNFDSLLWAIVTVFQ 969

Query: 649  LMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
            ++   +W V L      +  W+ +YFV      + +  NL +A+++E F  + D
Sbjct: 970  ILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGD 1023



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 73/297 (24%), Positives = 129/297 (43%), Gaps = 45/297 (15%)

Query: 414  RPEYQ--SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGI 471
            RP Y   SP  +S   L   +Y D     I   N++++     ++    P   D+  L  
Sbjct: 1591 RPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMS----MEHYNQPKSLDE-ALKY 1645

Query: 472  LNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWR 531
             N VF + ++ E  LK+ A G R +     N  D  L +VLL L   TL           
Sbjct: 1646 CNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLD--LAIVLLSLMGITLEEI-------- 1695

Query: 532  PEMVGLLSLWD-MTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY 590
             EM   L +   + R++ +L + R L+++     M  +  TV+  +  +   G + ++++
Sbjct: 1696 -EMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLF 1754

Query: 591  YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLM 650
            +++A +G+ LF        G    +  N   PC   E L   A  F +F  A +TL+ + 
Sbjct: 1755 FIYAALGVELF--------GRLECSEDN---PC---EGLSRHAT-FSNFGMAFLTLFRVS 1799

Query: 651  VVNNWQ-VFLDAYRR----------YSGPWSKIYFVLWWLVSSVIWVNLFLALILEN 696
              +NW  +  D  R           Y    S +YFV + LV+  + VN+ +A+++++
Sbjct: 1800 TGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKH 1856



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 63/279 (22%), Positives = 117/279 (41%), Gaps = 52/279 (18%)

Query: 82   CQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESV-----EVLCLLVF 136
            CQ+ ++  +F  + L FI       +   +       +P  G TE V       +   +F
Sbjct: 1287 CQKVITHKMFDHVVLVFI-----FLNCVTIALERPDIDP--GSTERVFLSVSNYIFTAIF 1339

Query: 137  AADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLS-------LVCHEPLR 185
             A++ VK    G L G   + ++ W L   ++++VSLVD  V+++       L     LR
Sbjct: 1340 VAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLR 1399

Query: 186  IRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG-KQD 244
            + R LRP  ++  +  +K  ++ +  SL  + ++ L+      +F + G+ LF G     
Sbjct: 1400 LLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYC 1459

Query: 245  DGQDRERLT-----------------YFQNLPESLTSLLVLLTTANNPDVMI-------- 279
            +G D   ++                  F NL ++L SL VL +     ++M         
Sbjct: 1460 EGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGV 1519

Query: 280  ---PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQF 315
               P  + N    ++FI F +I S F++N+   ++   F
Sbjct: 1520 DQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 58/270 (21%), Positives = 118/270 (43%), Gaps = 55/270 (20%)

Query: 91   FLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEV---LCLLVFAADLSVKGYLF 147
            +L LF+ FI   + +T + +       +  P  L E+++    +  +VF  + ++K   F
Sbjct: 1612 YLDLFITFIICVNVITMSME------HYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAF 1665

Query: 148  GWAHFQKNLWLLGYLVVLVVSLVDWTVS---------LSLVCHEPLRIRRLLRPFFLLQN 198
            G+  F K+ W    L ++++SL+  T+          ++      +R+ R+ R   LL+ 
Sbjct: 1666 GFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKM 1725

Query: 199  SSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDR-----ERLT 253
            ++ M+  L  +  +LP++ ++GLL  +   ++   G+ LF  G+ +  +D       R  
Sbjct: 1726 ATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF--GRLECSEDNPCEGLSRHA 1783

Query: 254  YFQNLPESLTSLLVLLTTANNPDVM-----------------IPAYSKNRAYAIFFIVFT 296
             F N   +  +L  + T  N   +M                 +PA S      ++F+ F 
Sbjct: 1784 TFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALS-----PVYFVTFV 1838

Query: 297  VIGSLFLMNLLTAIIYSQFRGYLMKSLQTS 326
            ++    L+N++ A+        LMK L+ S
Sbjct: 1839 LVAQFVLVNVVVAV--------LMKHLEES 1860



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 37/173 (21%), Positives = 86/173 (49%), Gaps = 17/173 (9%)

Query: 433 YFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALG 492
           +F+++  L+ + N V++ +F   +     +ER + IL   +     ++ +EM++K+ ALG
Sbjct: 101 WFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCN-ILEAFDAFIFAFFAVEMVIKMVALG 159

Query: 493 LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
           L G   Y  + ++ L   ++    ++ +  Y L         V L ++    R + +L  
Sbjct: 160 LFGQKCYLGDTWNRLDFFIV----VAGMMEYSLD-----GHNVSLSAI----RTVRVLRP 206

Query: 553 FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
            R +  +PSM+++  +    L ++ N+     +   V+++F I+G+ L+ G++
Sbjct: 207 LRAINRVPSMRILVTLLLDTLPMLGNVLL---LCFFVFFIFGIVGVQLWAGLL 256



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 49/211 (23%), Positives = 101/211 (47%), Gaps = 20/211 (9%)

Query: 119  EPPCGLTESVEVLCLL---VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV- 174
            E P  LT ++E+  ++   +FA ++ +K    G   + +N + +   +++V+S+  W + 
Sbjct: 816  EQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISV--WEIV 873

Query: 175  -----SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCL 229
                  LS+     LR  RLLR   L++    +++ L  +  ++  +A+   LL + + +
Sbjct: 874  GQADGGLSV-----LRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFI 928

Query: 230  FTMFGMLLFA---GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNR 286
            F++ GM LF      K D G        F +L  ++ ++  +LT  +   V+    +   
Sbjct: 929  FSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTS 988

Query: 287  AYA-IFFIVFTVIGSLFLMNLLTAIIYSQFR 316
            ++A ++F+     G+  L NLL AI+   F+
Sbjct: 989  SWAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 27/122 (22%), Positives = 56/122 (45%), Gaps = 3/122 (2%)

Query: 122 CGLTESVEVLCLLVFAADLSVKGY---LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSL 178
           C + E+ +      FA ++ +K     LFG   +  + W      ++V  ++++++    
Sbjct: 133 CNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHN 192

Query: 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
           V    +R  R+LRP   +     M+  +  +  +LP + +V LL      +F + G+ L+
Sbjct: 193 VSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252

Query: 239 AG 240
           AG
Sbjct: 253 AG 254



 Score = 33.5 bits (75), Expect = 0.75
 Identities = 17/62 (27%), Positives = 33/62 (53%), Gaps = 1/62 (1%)

Query: 255 FQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-IFFIVFTVIGSLFLMNLLTAIIYS 313
           F N+  +  ++  ++T     D+M      +  Y  I+FI+  ++GS F++NL   +I +
Sbjct: 361 FDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 420

Query: 314 QF 315
           QF
Sbjct: 421 QF 422



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 20/69 (28%), Positives = 34/69 (49%), Gaps = 8/69 (11%)

Query: 633 ANNFDDFAAALVTLWNLMVVNNW----QVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNL 688
           A NFD+   A + ++ ++ +  W       +DA+  Y+     IYF+L  +V S   +NL
Sbjct: 358 AINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNF----IYFILLIIVGSFFMINL 413

Query: 689 FLALILENF 697
            L +I   F
Sbjct: 414 CLVVIATQF 422


>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform a [Homo sapiens]
          Length = 2353

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 80/301 (26%), Positives = 138/301 (45%), Gaps = 38/301 (12%)

Query: 418  QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDA-DVLPAERDDFILGILNCVF 476
            Q+ F  S Q +  H  FD++  +    N    CV + L+  D+ P   +   L + N +F
Sbjct: 1280 QNRFRVSCQKVITHKMFDHVVLVFIFLN----CVTIALERPDIDPGSTERVFLSVSNYIF 1335

Query: 477  IVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
               ++ EM++KV ALGL      YL    N+ DGLL +V LV  +  +A           
Sbjct: 1336 TAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMA----------- 1384

Query: 533  EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV--- 589
               G   +  + R+L +L   R LR+I     + +V  T   L+ ++R  G I+++    
Sbjct: 1385 -SAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVET---LISSLRPIGNIVLICCAF 1440

Query: 590  YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
            + +F I+G+ LF+G      G  +   +  +    +  +      NFD+   AL++L+ L
Sbjct: 1441 FIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVL 1500

Query: 650  MVVNNWQVF----LDAYR------RYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
               + W       LDA        +   PW  +YF+ + L+ S   +N+F+ +++ENF H
Sbjct: 1501 SSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF-H 1559

Query: 700  K 700
            K
Sbjct: 1560 K 1560



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 66/234 (28%), Positives = 109/234 (46%), Gaps = 35/234 (14%)

Query: 469  LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
            L I N VF   + LEMLLK+ A G  GY+  P N+FDG++ VV+ V EI   A       
Sbjct: 825  LEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGII-VVISVWEIVGQA------- 876

Query: 529  GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
                   G LS+    R+L +L + RFL   P+++   VV   ++  + N+  F  +L++
Sbjct: 877  ------DGGLSVLRTFRLLRVLKLVRFL---PALRRQLVV---LVKTMDNVATFCTLLML 924

Query: 589  VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWN 648
              ++F+I+G++LF              P                  NFD    A+VT++ 
Sbjct: 925  FIFIFSILGMHLFGCKFSLKTDTGDTVPDR---------------KNFDSLLWAIVTVFQ 969

Query: 649  LMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
            ++   +W V L      +  W+ +YFV      + +  NL +A+++E F  + D
Sbjct: 970  ILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGD 1023



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 73/297 (24%), Positives = 129/297 (43%), Gaps = 45/297 (15%)

Query: 414  RPEYQ--SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGI 471
            RP Y   SP  +S   L   +Y D     I   N++++     ++    P   D+  L  
Sbjct: 1597 RPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMS----MEHYNQPKSLDE-ALKY 1651

Query: 472  LNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWR 531
             N VF + ++ E  LK+ A G R +     N  D  L +VLL L   TL           
Sbjct: 1652 CNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLD--LAIVLLSLMGITLEEI-------- 1701

Query: 532  PEMVGLLSLWD-MTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY 590
             EM   L +   + R++ +L + R L+++     M  +  TV+  +  +   G + ++++
Sbjct: 1702 -EMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLF 1760

Query: 591  YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLM 650
            +++A +G+ LF        G    +  N   PC   E L   A  F +F  A +TL+ + 
Sbjct: 1761 FIYAALGVELF--------GRLECSEDN---PC---EGLSRHAT-FSNFGMAFLTLFRVS 1805

Query: 651  VVNNWQ-VFLDAYRR----------YSGPWSKIYFVLWWLVSSVIWVNLFLALILEN 696
              +NW  +  D  R           Y    S +YFV + LV+  + VN+ +A+++++
Sbjct: 1806 TGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKH 1862



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 63/279 (22%), Positives = 117/279 (41%), Gaps = 52/279 (18%)

Query: 82   CQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESV-----EVLCLLVF 136
            CQ+ ++  +F  + L FI       +   +       +P  G TE V       +   +F
Sbjct: 1287 CQKVITHKMFDHVVLVFI-----FLNCVTIALERPDIDP--GSTERVFLSVSNYIFTAIF 1339

Query: 137  AADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLS-------LVCHEPLR 185
             A++ VK    G L G   + ++ W L   ++++VSLVD  V+++       L     LR
Sbjct: 1340 VAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLR 1399

Query: 186  IRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG-KQD 244
            + R LRP  ++  +  +K  ++ +  SL  + ++ L+      +F + G+ LF G     
Sbjct: 1400 LLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYC 1459

Query: 245  DGQDRERLT-----------------YFQNLPESLTSLLVLLTTANNPDVMI-------- 279
            +G D   ++                  F NL ++L SL VL +     ++M         
Sbjct: 1460 EGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGV 1519

Query: 280  ---PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQF 315
               P  + N    ++FI F +I S F++N+   ++   F
Sbjct: 1520 DQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 58/270 (21%), Positives = 118/270 (43%), Gaps = 55/270 (20%)

Query: 91   FLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEV---LCLLVFAADLSVKGYLF 147
            +L LF+ FI   + +T + +       +  P  L E+++    +  +VF  + ++K   F
Sbjct: 1618 YLDLFITFIICVNVITMSME------HYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAF 1671

Query: 148  GWAHFQKNLWLLGYLVVLVVSLVDWTVS---------LSLVCHEPLRIRRLLRPFFLLQN 198
            G+  F K+ W    L ++++SL+  T+          ++      +R+ R+ R   LL+ 
Sbjct: 1672 GFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKM 1731

Query: 199  SSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDR-----ERLT 253
            ++ M+  L  +  +LP++ ++GLL  +   ++   G+ LF  G+ +  +D       R  
Sbjct: 1732 ATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF--GRLECSEDNPCEGLSRHA 1789

Query: 254  YFQNLPESLTSLLVLLTTANNPDVM-----------------IPAYSKNRAYAIFFIVFT 296
             F N   +  +L  + T  N   +M                 +PA S      ++F+ F 
Sbjct: 1790 TFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALS-----PVYFVTFV 1844

Query: 297  VIGSLFLMNLLTAIIYSQFRGYLMKSLQTS 326
            ++    L+N++ A+        LMK L+ S
Sbjct: 1845 LVAQFVLVNVVVAV--------LMKHLEES 1866



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 37/173 (21%), Positives = 86/173 (49%), Gaps = 17/173 (9%)

Query: 433 YFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALG 492
           +F+++  L+ + N V++ +F   +     +ER + IL   +     ++ +EM++K+ ALG
Sbjct: 101 WFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCN-ILEAFDAFIFAFFAVEMVIKMVALG 159

Query: 493 LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
           L G   Y  + ++ L   ++    ++ +  Y L         V L ++    R + +L  
Sbjct: 160 LFGQKCYLGDTWNRLDFFIV----VAGMMEYSLD-----GHNVSLSAI----RTVRVLRP 206

Query: 553 FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
            R +  +PSM+++  +    L ++ N+     +   V+++F I+G+ L+ G++
Sbjct: 207 LRAINRVPSMRILVTLLLDTLPMLGNVLL---LCFFVFFIFGIVGVQLWAGLL 256



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 49/211 (23%), Positives = 101/211 (47%), Gaps = 20/211 (9%)

Query: 119  EPPCGLTESVEVLCLL---VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV- 174
            E P  LT ++E+  ++   +FA ++ +K    G   + +N + +   +++V+S+  W + 
Sbjct: 816  EQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISV--WEIV 873

Query: 175  -----SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCL 229
                  LS+     LR  RLLR   L++    +++ L  +  ++  +A+   LL + + +
Sbjct: 874  GQADGGLSV-----LRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFI 928

Query: 230  FTMFGMLLFA---GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNR 286
            F++ GM LF      K D G        F +L  ++ ++  +LT  +   V+    +   
Sbjct: 929  FSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTS 988

Query: 287  AYA-IFFIVFTVIGSLFLMNLLTAIIYSQFR 316
            ++A ++F+     G+  L NLL AI+   F+
Sbjct: 989  SWAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 27/122 (22%), Positives = 56/122 (45%), Gaps = 3/122 (2%)

Query: 122 CGLTESVEVLCLLVFAADLSVKGY---LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSL 178
           C + E+ +      FA ++ +K     LFG   +  + W      ++V  ++++++    
Sbjct: 133 CNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHN 192

Query: 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
           V    +R  R+LRP   +     M+  +  +  +LP + +V LL      +F + G+ L+
Sbjct: 193 VSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252

Query: 239 AG 240
           AG
Sbjct: 253 AG 254



 Score = 33.5 bits (75), Expect = 0.75
 Identities = 17/62 (27%), Positives = 33/62 (53%), Gaps = 1/62 (1%)

Query: 255 FQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-IFFIVFTVIGSLFLMNLLTAIIYS 313
           F N+  +  ++  ++T     D+M      +  Y  I+FI+  ++GS F++NL   +I +
Sbjct: 361 FDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 420

Query: 314 QF 315
           QF
Sbjct: 421 QF 422



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 20/69 (28%), Positives = 34/69 (49%), Gaps = 8/69 (11%)

Query: 633 ANNFDDFAAALVTLWNLMVVNNW----QVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNL 688
           A NFD+   A + ++ ++ +  W       +DA+  Y+     IYF+L  +V S   +NL
Sbjct: 358 AINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNF----IYFILLIIVGSFFMINL 413

Query: 689 FLALILENF 697
            L +I   F
Sbjct: 414 CLVVIATQF 422


>gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E
           subunit [Homo sapiens]
          Length = 2270

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 140/639 (21%), Positives = 262/639 (41%), Gaps = 126/639 (19%)

Query: 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSLVC 180
           E  E   + +F  +  +K    G++F    + +N W ++ ++VVL   L   T       
Sbjct: 125 EKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILA--TAGTHFNT 182

Query: 181 H---EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLL 237
           H     LR  R+LRP  L+     ++  LK I  ++  +  +GLLL   + +F + G+  
Sbjct: 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242

Query: 238 FAGGKQD----------DGQD----------------------RERLTYFQNLPESLTSL 265
           ++G              +G D                       + +T F N+  ++ ++
Sbjct: 243 YSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTV 302

Query: 266 LVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNLLTAIIYSQF----- 315
              +T      V+   Y+ N A       ++FI   +IGS F++NL+  ++  +F     
Sbjct: 303 FQCITMEGWTTVL---YNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERE 359

Query: 316 -----RGYLMKSLQTSLFRRRLGTRA----AFEVLSSMVGEGGAFPQAVGVKPQNLLQVL 366
                R ++    Q  + R   G RA    A EV+ +   +             + L+VL
Sbjct: 360 RVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAG---------TSALEVL 410

Query: 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQ-SA 425
           ++  +  S  +AM         V +S+     L     +S   +      ++   L+ S 
Sbjct: 411 RRATIKRSRTEAMTRDSSDEHCVDISSVG-TPLARASIKSAKVDGVSYFRHKERLLRISI 469

Query: 426 QFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEML 485
           + +     F ++  +++L  L + CV +V        +    +L     +F+  +LLEM 
Sbjct: 470 RHMVKSQVFYWI--VLSLVALNTACVAIVHHNQ---PQWLTHLLYYAEFLFLGLFLLEMS 524

Query: 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
           LK++ +G R Y     N FD  +TV   + E+    V+ +  PG              + 
Sbjct: 525 LKMYGMGPRLYFHSSFNCFDFGVTVGS-IFEV----VWAIFRPG-------------TSF 566

Query: 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY---VFAIIGINLFR 602
            +++L   R LRI    K  A + + V+ L+ +M++   +L +++    VFA++G+ LF 
Sbjct: 567 GISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 626

Query: 603 GVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNW-QVFLDA 661
           G      G  S                     NFD F AA++T++ ++   +W +V  + 
Sbjct: 627 GRFNFNDGTPSA--------------------NFDTFPAAIMTVFQILTGEDWNEVMYNG 666

Query: 662 YRRY----SGPWSKIYFVLWWLVSSVIWVNLFLALILEN 696
            R      SG WS IYF++  L  +   +N+FLA+ ++N
Sbjct: 667 IRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDN 705



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 60/266 (22%), Positives = 105/266 (39%), Gaps = 56/266 (21%)

Query: 466  DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRL 525
            +  L  LN  F + + LE +LKV A G   Y     N+FD  +TV+  + EI       +
Sbjct: 1507 ELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFD-FITVIGSITEIILTDSKLV 1565

Query: 526  PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
               G+                ++ L +FR  R+I  ++    +   +   VQ+ +A   +
Sbjct: 1566 NTSGFN---------------MSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1610

Query: 586  ---LVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAA 642
               + ++++++AIIG+ +F        GN  L            E      NNF  F  +
Sbjct: 1611 CLLIAMLFFIYAIIGMQVF--------GNIKL----------DEESHINRHNNFRSFFGS 1652

Query: 643  LVTLWNLMVVNNWQVFL-------------------DAYRRYSGPWSKIYFVLWWLVSSV 683
            L+ L+       WQ  +                   +   R     + +YFV +    S 
Sbjct: 1653 LMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSF 1712

Query: 684  IWVNLFLALILENFLHKWDPRSHLQP 709
            + +NLF+A+I++NF +     S L P
Sbjct: 1713 LMLNLFVAVIMDNFEYLTRDSSILGP 1738



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 64/306 (20%), Positives = 132/306 (43%), Gaps = 36/306 (11%)

Query: 419  SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
            +P  ++  ++    YF+    L+  A+ ++    L  +  VL     + +L   + VF  
Sbjct: 1140 NPIRRACHYIVNLRYFEMCILLVIAASSIA----LAAEDPVLTNSERNKVLRYFDYVFTG 1195

Query: 479  YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
             +  EM++K+   GL   +    + F  L  ++  V+ +  L  + L +       +G  
Sbjct: 1196 VFTFEMVIKMIDQGL---ILQDGSYFRDLWNILDFVVVVGALVAFALANA------LGTN 1246

Query: 539  SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV---YYVFAI 595
               D+ + +  L V R LR + ++K +  + +    +V +++    IL+V     ++FA+
Sbjct: 1247 KGRDI-KTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAV 1305

Query: 596  IGINLFRGVIVALPGNSSLAPAN--GSAPCGSFEQLEY----WAN---NFDDFAAALVTL 646
            I + LF+G       +S        G+       ++E     W     ++D+   AL+TL
Sbjct: 1306 IAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTL 1365

Query: 647  WNLMVVNNW----QVFLDAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILEN 696
            + +     W    Q  +D      GP         I++V++++V    +VN+F+ALI+  
Sbjct: 1366 FTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIIT 1425

Query: 697  FLHKWD 702
            F  + D
Sbjct: 1426 FQEQGD 1431



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 60/285 (21%), Positives = 117/285 (41%), Gaps = 42/285 (14%)

Query: 434 FDYLGNLIALANLVSICVFLVLDA-----DVLPAERDDFILGILNCVFIVYYLLEMLLKV 488
           F+Y+     LA +++ C+ L L+      D  P  R    L      FI  +  E  +K+
Sbjct: 91  FEYM----ILATIIANCIVLALEQHLPEDDKTPMSRR---LEKTEPYFIGIFCFEAGIKI 143

Query: 489 FALGLRGYL-SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRML 547
            ALG   +  SY  N ++ +  +V+L   ++T   +   H                 R L
Sbjct: 144 VALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVD--------------LRTL 189

Query: 548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI-- 605
             + V R L+++  +  + +V  +++  +  +   G +L     +FAIIG+  + G +  
Sbjct: 190 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249

Query: 606 VALPGNSSLAPA-NGSAPCG------SFEQLEYWANN-----FDDFAAALVTLWNLMVVN 653
                NS +    +   PCG       +E  ++   N     FD+   A++T++  + + 
Sbjct: 250 ACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITME 309

Query: 654 NW-QVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
            W  V  +        W+ +YF+   ++ S   +NL L ++   F
Sbjct: 310 GWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEF 354



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 46/232 (19%), Positives = 97/232 (41%), Gaps = 50/232 (21%)

Query: 135  VFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHE-------- 182
            VF  ++ +K    G +     + ++LW +   VV+V +LV + ++ +L  ++        
Sbjct: 1196 VFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIK 1255

Query: 183  PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG- 241
             LR+ R+LRP   ++    +K    C+  SL  + ++ ++  + + +F +  + LF G  
Sbjct: 1256 SLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKF 1315

Query: 242  --KQDDGQDRERLT------------------------YFQNLPESLTSLLVLLTTANNP 275
                D  +D E+                          ++ N+  +L +L  + T    P
Sbjct: 1316 FYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWP 1375

Query: 276  DVMI-----------PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
             V+            P+ S     +IF++V+ V+   F +N+  A+I   F+
Sbjct: 1376 QVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQ 1427



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 47/232 (20%), Positives = 97/232 (41%), Gaps = 29/232 (12%)

Query: 111  VRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLV 170
            ++Y +AP      L + + +   +VF+ +  +K   FG+ ++ ++ W +   + ++ S+ 
Sbjct: 1497 MKYYSAPCTYELAL-KYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSIT 1555

Query: 171  DWTVSLSLVCHEP------LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLA 224
            +  ++ S + +        L++ R  R   LL+    ++  L     S   +  V LL+A
Sbjct: 1556 EIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIA 1615

Query: 225  IHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLL----------VLLTTANN 274
            +   ++ + GM +F   K D+     R   F++   SL  L           ++L+    
Sbjct: 1616 MLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGE 1675

Query: 275  ----PDVMIPAYSKNR-------AYAIFFIVFTVIGSLFLMNLLTAIIYSQF 315
                PD   P+            AY ++F+ F    S  ++NL  A+I   F
Sbjct: 1676 KGCEPDTTAPSGQNENERCGTDLAY-VYFVSFIFFCSFLMLNLFVAVIMDNF 1726


>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
            isoform 1 [Homo sapiens]
          Length = 2377

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 132/613 (21%), Positives = 248/613 (40%), Gaps = 130/613 (21%)

Query: 135  VFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLS-------LVCHEP 183
            VF A+++VK    G+ FG   + ++ W +   +++++S++D  VS+        L     
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379

Query: 184  LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGK- 242
            LR+ R LRP  ++  +  +K  ++ +  SL  + ++ ++      +F + G+ LF G   
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439

Query: 243  QDDGQDRERLTY-----------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
               G+D   +T                  F NL ++L SL VL +     D+M       
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P  + N    ++FI F +I + F++N+   ++   F        +    RR    
Sbjct: 1500 GVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRRE--- 1556

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                                     +  L+ L+K       +  M++ V + GS   +A 
Sbjct: 1557 -------------------------EKRLRRLEK-----KRRNLMLDDVIASGSSASAAS 1586

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV 454
            E Q              P   +Y    L        HY   ++  +I L N+V++ +   
Sbjct: 1587 EAQC------------KPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGL-NVVTMAMEHY 1633

Query: 455  LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLV 514
                +L     D  L I N +F V ++LE + K+ A G R +     N  D  L +VLL 
Sbjct: 1634 QQPQIL-----DEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLD--LAIVLLS 1686

Query: 515  LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKL---MAVVAST 571
            +   TL            E+    SL     ++ ++ V R  R++  +K+   M  +  T
Sbjct: 1687 IMGITLE-----------EIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDT 1735

Query: 572  VLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEY 631
            V+  +  +   G + ++++++FA +G+ LF  +             + + PC   E L  
Sbjct: 1736 VMQALPQVGNLGLLFMLLFFIFAALGVELFGDL-----------ECDETHPC---EGLGR 1781

Query: 632  WANNFDDFAAALVTLWNLMVVNNWQ-VFLDAYRR-------YSGPWSKIYFVLWWLVSSV 683
             A  F +F  A +TL+ +   +NW  +  D  R        Y+   S IYFV + L +  
Sbjct: 1782 HA-TFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQF 1840

Query: 684  IWVNLFLALILEN 696
            + VN+ +A+++++
Sbjct: 1841 VLVNVVIAVLMKH 1853



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 75/301 (24%), Positives = 135/301 (44%), Gaps = 38/301 (12%)

Query: 418  QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVL-PAERDDFILGILNCVF 476
            QS F      +  H  FD++  +I   N    C+ + ++   + P   +   L + N +F
Sbjct: 1262 QSRFRLLCHRIITHKMFDHVVLVIIFLN----CITIAMERPKIDPHSAERIFLTLSNYIF 1317

Query: 477  IVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
               +L EM +KV ALG     + YL    NV DGLL ++ ++     + V  +   G + 
Sbjct: 1318 TAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVI----DILVSMVSDSGTK- 1372

Query: 533  EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV--- 589
                   +  M R+L +L   R LR+I   + + +V  T   L+ +++  G I+V+    
Sbjct: 1373 -------ILGMLRVLRLLRTLRPLRVISRAQGLKLVVET---LMSSLKPIGNIVVICCAF 1422

Query: 590  YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
            + +F I+G+ LF+G      G  +    N S    +  +      NFD+   AL++L+ L
Sbjct: 1423 FIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVL 1482

Query: 650  MVVNNW-QVFLDAYRRYS---------GPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
               + W  +  D                PW  +YF+ + L+ +   +N+F+ +++ENF H
Sbjct: 1483 ASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF-H 1541

Query: 700  K 700
            K
Sbjct: 1542 K 1542



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 70/262 (26%), Positives = 123/262 (46%), Gaps = 38/262 (14%)

Query: 436 YLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG 495
           Y G  I +A LV+  + + ++    P E  +  L I N VF   + LEMLLK+   G  G
Sbjct: 744 YFGRGIMIAILVNT-LSMGIEYHEQPEELTN-ALEISNIVFTSLFALEMLLKLLVYGPFG 801

Query: 496 YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
           Y+  P N+FDG++ VV+ V EI               +  G LS+    R++ +L + RF
Sbjct: 802 YIKNPYNIFDGVI-VVISVWEIV-------------GQQGGGLSVLRTFRLMRVLKLVRF 847

Query: 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLA 615
           L   P+++   VV   ++  + N+  F  +L++  ++F+I+G++LF G   A   +    
Sbjct: 848 L---PALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKFASERDGDTL 900

Query: 616 PANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFV 675
           P                  NFD    A+VT++ ++   +W   L      +  W+ +YF+
Sbjct: 901 PDR---------------KNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 676 LWWLVSSVIWVNLFLALILENF 697
                 + +  NL +A+++E F
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGF 967



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 50/210 (23%), Positives = 104/210 (49%), Gaps = 19/210 (9%)

Query: 119 EPPCGLTESVEVLCLL---VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV- 174
           E P  LT ++E+  ++   +FA ++ +K  ++G   + KN + +   V++V+S+  W + 
Sbjct: 766 EQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISV--WEIV 823

Query: 175 -----SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCL 229
                 LS+     LR  RL+R   L++    +++ L  +  ++  +A+  +LL + + +
Sbjct: 824 GQQGGGLSV-----LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFI 878

Query: 230 FTMFGMLLFAG--GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
           F++ GM LF      + DG        F +L  ++ ++  +LT  +   V+    +   +
Sbjct: 879 FSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS 938

Query: 288 YA-IFFIVFTVIGSLFLMNLLTAIIYSQFR 316
           +A ++FI     G+  L NLL AI+   F+
Sbjct: 939 WAALYFIALMTFGNYVLFNLLVAILVEGFQ 968



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 67/340 (19%), Positives = 132/340 (38%), Gaps = 98/340 (28%)

Query: 433 YFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALG 492
           +F+ +  L+ L N V++ +F   +     ++R   +    + +F  ++ +EM++K+ ALG
Sbjct: 82  WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFAVEMVVKMVALG 140

Query: 493 LRGYLSYPSNVFDGL--LTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNML 550
           + G   Y  + ++ L    V+  +LE S L +  +               +   R + +L
Sbjct: 141 IFGKKCYLGDTWNRLDFFIVIAGMLEYS-LDLQNVS--------------FSAVRTVRVL 185

Query: 551 IVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI---VA 607
              R +  +PSM+++  +    L ++ N+     +   V+++F I+G+ L+ G++     
Sbjct: 186 RPLRAINRVPSMRILVTLLLDTLPMLGNVLL---LCFFVFFIFGIVGVQLWAGLLRNRCF 242

Query: 608 LPGNSSL----------------------------------------APANGSAPCG-SF 626
           LP N SL                                            G  PCG  +
Sbjct: 243 LPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDY 302

Query: 627 EQL------------EYWAN-------------NFDDFAAALVTLWNLMVVNNW----QV 657
           E              +Y+ N             NFD+   A + ++ ++ +  W      
Sbjct: 303 EAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYF 362

Query: 658 FLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
            +DA+  Y    + IYF+L  +V S   +NL L +I   F
Sbjct: 363 VMDAHSFY----NFIYFILLIIVGSFFMINLCLVVIATQF 398



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 52/233 (22%), Positives = 105/233 (45%), Gaps = 32/233 (13%)

Query: 118  WEPPCGLTESVEV---LCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWT- 173
            ++ P  L E++++   +  ++F  +   K   FG+  F ++ W    L ++++S++  T 
Sbjct: 1633 YQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITL 1692

Query: 174  ----VSLSLVCHEPL----RIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAI 225
                V+ SL  +  +    R+ R+ R   LL+ +  M+  L  +  +LP++ ++GLL  +
Sbjct: 1693 EEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFML 1752

Query: 226  HLCLFTMFGMLLFAGGKQDDGQDRE---RLTYFQNLPESLTSLLVLLTTAN----NPDVM 278
               +F   G+ LF   + D+    E   R   F+N   +  +L  + T  N      D +
Sbjct: 1753 LFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1812

Query: 279  IPAYSKNRAY-----AIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTS 326
                 ++  Y      I+F+ F +     L+N++ A+        LMK L+ S
Sbjct: 1813 RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV--------LMKHLEES 1857



 Score = 37.7 bits (86), Expect = 0.040
 Identities = 26/122 (21%), Positives = 57/122 (46%), Gaps = 3/122 (2%)

Query: 122 CGLTESVEVLCLLVFAADLSVKGY---LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSL 178
           C + ++ +      FA ++ VK     +FG   +  + W      +++  ++++++ L  
Sbjct: 114 CRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN 173

Query: 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
           V    +R  R+LRP   +     M+  +  +  +LP + +V LL      +F + G+ L+
Sbjct: 174 VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233

Query: 239 AG 240
           AG
Sbjct: 234 AG 235



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 17/62 (27%), Positives = 33/62 (53%), Gaps = 1/62 (1%)

Query: 255 FQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-IFFIVFTVIGSLFLMNLLTAIIYS 313
           F N+  +  ++  ++T     D+M      +  Y  I+FI+  ++GS F++NL   +I +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 396

Query: 314 QF 315
           QF
Sbjct: 397 QF 398


>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
            isoform 4 [Homo sapiens]
          Length = 2332

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 132/613 (21%), Positives = 248/613 (40%), Gaps = 130/613 (21%)

Query: 135  VFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLS-------LVCHEP 183
            VF A+++VK    G+ FG   + ++ W +   +++++S++D  VS+        L     
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379

Query: 184  LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGK- 242
            LR+ R LRP  ++  +  +K  ++ +  SL  + ++ ++      +F + G+ LF G   
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439

Query: 243  QDDGQDRERLTY-----------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
               G+D   +T                  F NL ++L SL VL +     D+M       
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P  + N    ++FI F +I + F++N+   ++   F        +    RR    
Sbjct: 1500 GVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRRE--- 1556

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                                     +  L+ L+K       +  M++ V + GS   +A 
Sbjct: 1557 -------------------------EKRLRRLEK-----KRRNLMLDDVIASGSSASAAS 1586

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV 454
            E Q              P   +Y    L        HY   ++  +I L N+V++ +   
Sbjct: 1587 EAQC------------KPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGL-NVVTMAMEHY 1633

Query: 455  LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLV 514
                +L     D  L I N +F V ++LE + K+ A G R +     N  D  L +VLL 
Sbjct: 1634 QQPQIL-----DEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLD--LAIVLLS 1686

Query: 515  LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKL---MAVVAST 571
            +   TL            E+    SL     ++ ++ V R  R++  +K+   M  +  T
Sbjct: 1687 IMGITLE-----------EIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDT 1735

Query: 572  VLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEY 631
            V+  +  +   G + ++++++FA +G+ LF  +             + + PC   E L  
Sbjct: 1736 VMQALPQVGNLGLLFMLLFFIFAALGVELFGDL-----------ECDETHPC---EGLGR 1781

Query: 632  WANNFDDFAAALVTLWNLMVVNNWQ-VFLDAYRR-------YSGPWSKIYFVLWWLVSSV 683
             A  F +F  A +TL+ +   +NW  +  D  R        Y+   S IYFV + L +  
Sbjct: 1782 HA-TFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQF 1840

Query: 684  IWVNLFLALILEN 696
            + VN+ +A+++++
Sbjct: 1841 VLVNVVIAVLMKH 1853



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 75/301 (24%), Positives = 135/301 (44%), Gaps = 38/301 (12%)

Query: 418  QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVL-PAERDDFILGILNCVF 476
            QS F      +  H  FD++  +I   N    C+ + ++   + P   +   L + N +F
Sbjct: 1262 QSRFRLLCHRIITHKMFDHVVLVIIFLN----CITIAMERPKIDPHSAERIFLTLSNYIF 1317

Query: 477  IVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
               +L EM +KV ALG     + YL    NV DGLL ++ ++     + V  +   G + 
Sbjct: 1318 TAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVI----DILVSMVSDSGTK- 1372

Query: 533  EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV--- 589
                   +  M R+L +L   R LR+I   + + +V  T   L+ +++  G I+V+    
Sbjct: 1373 -------ILGMLRVLRLLRTLRPLRVISRAQGLKLVVET---LMSSLKPIGNIVVICCAF 1422

Query: 590  YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
            + +F I+G+ LF+G      G  +    N S    +  +      NFD+   AL++L+ L
Sbjct: 1423 FIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVL 1482

Query: 650  MVVNNW-QVFLDAYRRYS---------GPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
               + W  +  D                PW  +YF+ + L+ +   +N+F+ +++ENF H
Sbjct: 1483 ASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF-H 1541

Query: 700  K 700
            K
Sbjct: 1542 K 1542



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 70/262 (26%), Positives = 123/262 (46%), Gaps = 38/262 (14%)

Query: 436 YLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG 495
           Y G  I +A LV+  + + ++    P E  +  L I N VF   + LEMLLK+   G  G
Sbjct: 744 YFGRGIMIAILVNT-LSMGIEYHEQPEELTN-ALEISNIVFTSLFALEMLLKLLVYGPFG 801

Query: 496 YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
           Y+  P N+FDG++ VV+ V EI               +  G LS+    R++ +L + RF
Sbjct: 802 YIKNPYNIFDGVI-VVISVWEIV-------------GQQGGGLSVLRTFRLMRVLKLVRF 847

Query: 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLA 615
           L   P+++   VV   ++  + N+  F  +L++  ++F+I+G++LF G   A   +    
Sbjct: 848 L---PALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKFASERDGDTL 900

Query: 616 PANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFV 675
           P                  NFD    A+VT++ ++   +W   L      +  W+ +YF+
Sbjct: 901 PDR---------------KNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 676 LWWLVSSVIWVNLFLALILENF 697
                 + +  NL +A+++E F
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGF 967



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 50/210 (23%), Positives = 104/210 (49%), Gaps = 19/210 (9%)

Query: 119 EPPCGLTESVEVLCLL---VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV- 174
           E P  LT ++E+  ++   +FA ++ +K  ++G   + KN + +   V++V+S+  W + 
Sbjct: 766 EQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISV--WEIV 823

Query: 175 -----SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCL 229
                 LS+     LR  RL+R   L++    +++ L  +  ++  +A+  +LL + + +
Sbjct: 824 GQQGGGLSV-----LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFI 878

Query: 230 FTMFGMLLFAG--GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
           F++ GM LF      + DG        F +L  ++ ++  +LT  +   V+    +   +
Sbjct: 879 FSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS 938

Query: 288 YA-IFFIVFTVIGSLFLMNLLTAIIYSQFR 316
           +A ++FI     G+  L NLL AI+   F+
Sbjct: 939 WAALYFIALMTFGNYVLFNLLVAILVEGFQ 968



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 67/340 (19%), Positives = 132/340 (38%), Gaps = 98/340 (28%)

Query: 433 YFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALG 492
           +F+ +  L+ L N V++ +F   +     ++R   +    + +F  ++ +EM++K+ ALG
Sbjct: 82  WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFAVEMVVKMVALG 140

Query: 493 LRGYLSYPSNVFDGL--LTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNML 550
           + G   Y  + ++ L    V+  +LE S L +  +               +   R + +L
Sbjct: 141 IFGKKCYLGDTWNRLDFFIVIAGMLEYS-LDLQNVS--------------FSAVRTVRVL 185

Query: 551 IVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI---VA 607
              R +  +PSM+++  +    L ++ N+     +   V+++F I+G+ L+ G++     
Sbjct: 186 RPLRAINRVPSMRILVTLLLDTLPMLGNVLL---LCFFVFFIFGIVGVQLWAGLLRNRCF 242

Query: 608 LPGNSSL----------------------------------------APANGSAPCG-SF 626
           LP N SL                                            G  PCG  +
Sbjct: 243 LPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDY 302

Query: 627 EQL------------EYWAN-------------NFDDFAAALVTLWNLMVVNNW----QV 657
           E              +Y+ N             NFD+   A + ++ ++ +  W      
Sbjct: 303 EAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYF 362

Query: 658 FLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
            +DA+  Y    + IYF+L  +V S   +NL L +I   F
Sbjct: 363 VMDAHSFY----NFIYFILLIIVGSFFMINLCLVVIATQF 398



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 52/233 (22%), Positives = 105/233 (45%), Gaps = 32/233 (13%)

Query: 118  WEPPCGLTESVEV---LCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWT- 173
            ++ P  L E++++   +  ++F  +   K   FG+  F ++ W    L ++++S++  T 
Sbjct: 1633 YQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITL 1692

Query: 174  ----VSLSLVCHEPL----RIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAI 225
                V+ SL  +  +    R+ R+ R   LL+ +  M+  L  +  +LP++ ++GLL  +
Sbjct: 1693 EEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFML 1752

Query: 226  HLCLFTMFGMLLFAGGKQDDGQDRE---RLTYFQNLPESLTSLLVLLTTAN----NPDVM 278
               +F   G+ LF   + D+    E   R   F+N   +  +L  + T  N      D +
Sbjct: 1753 LFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1812

Query: 279  IPAYSKNRAY-----AIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTS 326
                 ++  Y      I+F+ F +     L+N++ A+        LMK L+ S
Sbjct: 1813 RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV--------LMKHLEES 1857



 Score = 37.7 bits (86), Expect = 0.040
 Identities = 26/122 (21%), Positives = 57/122 (46%), Gaps = 3/122 (2%)

Query: 122 CGLTESVEVLCLLVFAADLSVKGY---LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSL 178
           C + ++ +      FA ++ VK     +FG   +  + W      +++  ++++++ L  
Sbjct: 114 CRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN 173

Query: 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
           V    +R  R+LRP   +     M+  +  +  +LP + +V LL      +F + G+ L+
Sbjct: 174 VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233

Query: 239 AG 240
           AG
Sbjct: 234 AG 235



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 17/62 (27%), Positives = 33/62 (53%), Gaps = 1/62 (1%)

Query: 255 FQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-IFFIVFTVIGSLFLMNLLTAIIYS 313
           F N+  +  ++  ++T     D+M      +  Y  I+FI+  ++GS F++NL   +I +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 396

Query: 314 QF 315
           QF
Sbjct: 397 QF 398


>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
            isoform 8 [Homo sapiens]
          Length = 2284

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 132/613 (21%), Positives = 248/613 (40%), Gaps = 130/613 (21%)

Query: 135  VFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLS-------LVCHEP 183
            VF A+++VK    G+ FG   + ++ W +   +++++S++D  VS+        L     
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379

Query: 184  LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGK- 242
            LR+ R LRP  ++  +  +K  ++ +  SL  + ++ ++      +F + G+ LF G   
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439

Query: 243  QDDGQDRERLTY-----------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
               G+D   +T                  F NL ++L SL VL +     D+M       
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P  + N    ++FI F +I + F++N+   ++   F        +    RR    
Sbjct: 1500 GVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRRE--- 1556

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                                     +  L+ L+K       +  M++ V + GS   +A 
Sbjct: 1557 -------------------------EKRLRRLEK-----KRRNLMLDDVIASGSSASAAS 1586

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV 454
            E Q              P   +Y    L        HY   ++  +I L N+V++ +   
Sbjct: 1587 EAQC------------KPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGL-NVVTMAMEHY 1633

Query: 455  LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLV 514
                +L     D  L I N +F V ++LE + K+ A G R +     N  D  L +VLL 
Sbjct: 1634 QQPQIL-----DEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLD--LAIVLLS 1686

Query: 515  LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKL---MAVVAST 571
            +   TL            E+    SL     ++ ++ V R  R++  +K+   M  +  T
Sbjct: 1687 IMGITLE-----------EIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDT 1735

Query: 572  VLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEY 631
            V+  +  +   G + ++++++FA +G+ LF  +             + + PC   E L  
Sbjct: 1736 VMQALPQVGNLGLLFMLLFFIFAALGVELFGDL-----------ECDETHPC---EGLGR 1781

Query: 632  WANNFDDFAAALVTLWNLMVVNNWQ-VFLDAYRR-------YSGPWSKIYFVLWWLVSSV 683
             A  F +F  A +TL+ +   +NW  +  D  R        Y+   S IYFV + L +  
Sbjct: 1782 HA-TFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQF 1840

Query: 684  IWVNLFLALILEN 696
            + VN+ +A+++++
Sbjct: 1841 VLVNVVIAVLMKH 1853



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 75/301 (24%), Positives = 135/301 (44%), Gaps = 38/301 (12%)

Query: 418  QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVL-PAERDDFILGILNCVF 476
            QS F      +  H  FD++  +I   N    C+ + ++   + P   +   L + N +F
Sbjct: 1262 QSRFRLLCHRIITHKMFDHVVLVIIFLN----CITIAMERPKIDPHSAERIFLTLSNYIF 1317

Query: 477  IVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
               +L EM +KV ALG     + YL    NV DGLL ++ ++     + V  +   G + 
Sbjct: 1318 TAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVI----DILVSMVSDSGTK- 1372

Query: 533  EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV--- 589
                   +  M R+L +L   R LR+I   + + +V  T   L+ +++  G I+V+    
Sbjct: 1373 -------ILGMLRVLRLLRTLRPLRVISRAQGLKLVVET---LMSSLKPIGNIVVICCAF 1422

Query: 590  YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
            + +F I+G+ LF+G      G  +    N S    +  +      NFD+   AL++L+ L
Sbjct: 1423 FIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVL 1482

Query: 650  MVVNNW-QVFLDAYRRYS---------GPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
               + W  +  D                PW  +YF+ + L+ +   +N+F+ +++ENF H
Sbjct: 1483 ASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF-H 1541

Query: 700  K 700
            K
Sbjct: 1542 K 1542



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 70/262 (26%), Positives = 123/262 (46%), Gaps = 38/262 (14%)

Query: 436 YLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG 495
           Y G  I +A LV+  + + ++    P E  +  L I N VF   + LEMLLK+   G  G
Sbjct: 744 YFGRGIMIAILVNT-LSMGIEYHEQPEELTN-ALEISNIVFTSLFALEMLLKLLVYGPFG 801

Query: 496 YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
           Y+  P N+FDG++ VV+ V EI               +  G LS+    R++ +L + RF
Sbjct: 802 YIKNPYNIFDGVI-VVISVWEIV-------------GQQGGGLSVLRTFRLMRVLKLVRF 847

Query: 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLA 615
           L   P+++   VV   ++  + N+  F  +L++  ++F+I+G++LF G   A   +    
Sbjct: 848 L---PALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKFASERDGDTL 900

Query: 616 PANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFV 675
           P                  NFD    A+VT++ ++   +W   L      +  W+ +YF+
Sbjct: 901 PDR---------------KNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 676 LWWLVSSVIWVNLFLALILENF 697
                 + +  NL +A+++E F
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGF 967



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 50/210 (23%), Positives = 104/210 (49%), Gaps = 19/210 (9%)

Query: 119 EPPCGLTESVEVLCLL---VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV- 174
           E P  LT ++E+  ++   +FA ++ +K  ++G   + KN + +   V++V+S+  W + 
Sbjct: 766 EQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISV--WEIV 823

Query: 175 -----SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCL 229
                 LS+     LR  RL+R   L++    +++ L  +  ++  +A+  +LL + + +
Sbjct: 824 GQQGGGLSV-----LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFI 878

Query: 230 FTMFGMLLFAG--GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
           F++ GM LF      + DG        F +L  ++ ++  +LT  +   V+    +   +
Sbjct: 879 FSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS 938

Query: 288 YA-IFFIVFTVIGSLFLMNLLTAIIYSQFR 316
           +A ++FI     G+  L NLL AI+   F+
Sbjct: 939 WAALYFIALMTFGNYVLFNLLVAILVEGFQ 968



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 67/340 (19%), Positives = 132/340 (38%), Gaps = 98/340 (28%)

Query: 433 YFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALG 492
           +F+ +  L+ L N V++ +F   +     ++R   +    + +F  ++ +EM++K+ ALG
Sbjct: 82  WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFAVEMVVKMVALG 140

Query: 493 LRGYLSYPSNVFDGL--LTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNML 550
           + G   Y  + ++ L    V+  +LE S L +  +               +   R + +L
Sbjct: 141 IFGKKCYLGDTWNRLDFFIVIAGMLEYS-LDLQNVS--------------FSAVRTVRVL 185

Query: 551 IVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI---VA 607
              R +  +PSM+++  +    L ++ N+     +   V+++F I+G+ L+ G++     
Sbjct: 186 RPLRAINRVPSMRILVTLLLDTLPMLGNVLL---LCFFVFFIFGIVGVQLWAGLLRNRCF 242

Query: 608 LPGNSSL----------------------------------------APANGSAPCG-SF 626
           LP N SL                                            G  PCG  +
Sbjct: 243 LPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDY 302

Query: 627 EQL------------EYWAN-------------NFDDFAAALVTLWNLMVVNNW----QV 657
           E              +Y+ N             NFD+   A + ++ ++ +  W      
Sbjct: 303 EAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYF 362

Query: 658 FLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
            +DA+  Y    + IYF+L  +V S   +NL L +I   F
Sbjct: 363 VMDAHSFY----NFIYFILLIIVGSFFMINLCLVVIATQF 398



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 52/233 (22%), Positives = 105/233 (45%), Gaps = 32/233 (13%)

Query: 118  WEPPCGLTESVEV---LCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWT- 173
            ++ P  L E++++   +  ++F  +   K   FG+  F ++ W    L ++++S++  T 
Sbjct: 1633 YQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITL 1692

Query: 174  ----VSLSLVCHEPL----RIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAI 225
                V+ SL  +  +    R+ R+ R   LL+ +  M+  L  +  +LP++ ++GLL  +
Sbjct: 1693 EEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFML 1752

Query: 226  HLCLFTMFGMLLFAGGKQDDGQDRE---RLTYFQNLPESLTSLLVLLTTAN----NPDVM 278
               +F   G+ LF   + D+    E   R   F+N   +  +L  + T  N      D +
Sbjct: 1753 LFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1812

Query: 279  IPAYSKNRAY-----AIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTS 326
                 ++  Y      I+F+ F +     L+N++ A+        LMK L+ S
Sbjct: 1813 RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV--------LMKHLEES 1857



 Score = 37.7 bits (86), Expect = 0.040
 Identities = 26/122 (21%), Positives = 57/122 (46%), Gaps = 3/122 (2%)

Query: 122 CGLTESVEVLCLLVFAADLSVKGY---LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSL 178
           C + ++ +      FA ++ VK     +FG   +  + W      +++  ++++++ L  
Sbjct: 114 CRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN 173

Query: 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
           V    +R  R+LRP   +     M+  +  +  +LP + +V LL      +F + G+ L+
Sbjct: 174 VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233

Query: 239 AG 240
           AG
Sbjct: 234 AG 235



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 17/62 (27%), Positives = 33/62 (53%), Gaps = 1/62 (1%)

Query: 255 FQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-IFFIVFTVIGSLFLMNLLTAIIYS 313
           F N+  +  ++  ++T     D+M      +  Y  I+FI+  ++GS F++NL   +I +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 396

Query: 314 QF 315
           QF
Sbjct: 397 QF 398


>gi|38505280 voltage-dependent calcium channel alpha 1G subunit
            isoform 6 [Homo sapiens]
          Length = 2306

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 132/613 (21%), Positives = 248/613 (40%), Gaps = 130/613 (21%)

Query: 135  VFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLS-------LVCHEP 183
            VF A+++VK    G+ FG   + ++ W +   +++++S++D  VS+        L     
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356

Query: 184  LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGK- 242
            LR+ R LRP  ++  +  +K  ++ +  SL  + ++ ++      +F + G+ LF G   
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416

Query: 243  QDDGQDRERLTY-----------------FQNLPESLTSLLVLLTTANNPDVMI------ 279
               G+D   +T                  F NL ++L SL VL +     D+M       
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476

Query: 280  -----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
                 P  + N    ++FI F +I + F++N+   ++   F        +    RR    
Sbjct: 1477 GVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRRE--- 1533

Query: 335  RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
                                     +  L+ L+K       +  M++ V + GS   +A 
Sbjct: 1534 -------------------------EKRLRRLEK-----KRRNLMLDDVIASGSSASAAS 1563

Query: 395  EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV 454
            E Q              P   +Y    L        HY   ++  +I L N+V++ +   
Sbjct: 1564 EAQC------------KPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGL-NVVTMAMEHY 1610

Query: 455  LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLV 514
                +L     D  L I N +F V ++LE + K+ A G R +     N  D  L +VLL 
Sbjct: 1611 QQPQIL-----DEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLD--LAIVLLS 1663

Query: 515  LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKL---MAVVAST 571
            +   TL            E+    SL     ++ ++ V R  R++  +K+   M  +  T
Sbjct: 1664 IMGITLE-----------EIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDT 1712

Query: 572  VLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEY 631
            V+  +  +   G + ++++++FA +G+ LF  +             + + PC   E L  
Sbjct: 1713 VMQALPQVGNLGLLFMLLFFIFAALGVELFGDL-----------ECDETHPC---EGLGR 1758

Query: 632  WANNFDDFAAALVTLWNLMVVNNWQ-VFLDAYRR-------YSGPWSKIYFVLWWLVSSV 683
             A  F +F  A +TL+ +   +NW  +  D  R        Y+   S IYFV + L +  
Sbjct: 1759 HA-TFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQF 1817

Query: 684  IWVNLFLALILEN 696
            + VN+ +A+++++
Sbjct: 1818 VLVNVVIAVLMKH 1830



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 75/301 (24%), Positives = 135/301 (44%), Gaps = 38/301 (12%)

Query: 418  QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVL-PAERDDFILGILNCVF 476
            QS F      +  H  FD++  +I   N    C+ + ++   + P   +   L + N +F
Sbjct: 1239 QSRFRLLCHRIITHKMFDHVVLVIIFLN----CITIAMERPKIDPHSAERIFLTLSNYIF 1294

Query: 477  IVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
               +L EM +KV ALG     + YL    NV DGLL ++ ++     + V  +   G + 
Sbjct: 1295 TAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVI----DILVSMVSDSGTK- 1349

Query: 533  EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV--- 589
                   +  M R+L +L   R LR+I   + + +V  T   L+ +++  G I+V+    
Sbjct: 1350 -------ILGMLRVLRLLRTLRPLRVISRAQGLKLVVET---LMSSLKPIGNIVVICCAF 1399

Query: 590  YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
            + +F I+G+ LF+G      G  +    N S    +  +      NFD+   AL++L+ L
Sbjct: 1400 FIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVL 1459

Query: 650  MVVNNW-QVFLDAYRRYS---------GPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
               + W  +  D                PW  +YF+ + L+ +   +N+F+ +++ENF H
Sbjct: 1460 ASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF-H 1518

Query: 700  K 700
            K
Sbjct: 1519 K 1519



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 71/267 (26%), Positives = 125/267 (46%), Gaps = 38/267 (14%)

Query: 436 YLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG 495
           Y G  I +A LV+  + + ++    P E  +  L I N VF   + LEMLLK+   G  G
Sbjct: 744 YFGRGIMIAILVNT-LSMGIEYHEQPEELTN-ALEISNIVFTSLFALEMLLKLLVYGPFG 801

Query: 496 YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
           Y+  P N+FDG++ VV+ V EI               +  G LS+    R++ +L + RF
Sbjct: 802 YIKNPYNIFDGVI-VVISVWEIV-------------GQQGGGLSVLRTFRLMRVLKLVRF 847

Query: 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLA 615
           L   P+++   VV   ++  + N+  F  +L++  ++F+I+G++LF G   A   +    
Sbjct: 848 L---PALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKFASERDGDTL 900

Query: 616 PANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFV 675
           P                  NFD    A+VT++ ++   +W   L      +  W+ +YF+
Sbjct: 901 PDR---------------KNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 676 LWWLVSSVIWVNLFLALILENFLHKWD 702
                 + +  NL +A+++E F  + D
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGFQAEGD 972



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 50/210 (23%), Positives = 104/210 (49%), Gaps = 19/210 (9%)

Query: 119 EPPCGLTESVEVLCLL---VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV- 174
           E P  LT ++E+  ++   +FA ++ +K  ++G   + KN + +   V++V+S+  W + 
Sbjct: 766 EQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISV--WEIV 823

Query: 175 -----SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCL 229
                 LS+     LR  RL+R   L++    +++ L  +  ++  +A+  +LL + + +
Sbjct: 824 GQQGGGLSV-----LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFI 878

Query: 230 FTMFGMLLFAG--GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
           F++ GM LF      + DG        F +L  ++ ++  +LT  +   V+    +   +
Sbjct: 879 FSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS 938

Query: 288 YA-IFFIVFTVIGSLFLMNLLTAIIYSQFR 316
           +A ++FI     G+  L NLL AI+   F+
Sbjct: 939 WAALYFIALMTFGNYVLFNLLVAILVEGFQ 968



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 67/340 (19%), Positives = 132/340 (38%), Gaps = 98/340 (28%)

Query: 433 YFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALG 492
           +F+ +  L+ L N V++ +F   +     ++R   +    + +F  ++ +EM++K+ ALG
Sbjct: 82  WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFAVEMVVKMVALG 140

Query: 493 LRGYLSYPSNVFDGL--LTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNML 550
           + G   Y  + ++ L    V+  +LE S L +  +               +   R + +L
Sbjct: 141 IFGKKCYLGDTWNRLDFFIVIAGMLEYS-LDLQNVS--------------FSAVRTVRVL 185

Query: 551 IVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI---VA 607
              R +  +PSM+++  +    L ++ N+     +   V+++F I+G+ L+ G++     
Sbjct: 186 RPLRAINRVPSMRILVTLLLDTLPMLGNVLL---LCFFVFFIFGIVGVQLWAGLLRNRCF 242

Query: 608 LPGNSSL----------------------------------------APANGSAPCG-SF 626
           LP N SL                                            G  PCG  +
Sbjct: 243 LPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDY 302

Query: 627 EQL------------EYWAN-------------NFDDFAAALVTLWNLMVVNNW----QV 657
           E              +Y+ N             NFD+   A + ++ ++ +  W      
Sbjct: 303 EAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYF 362

Query: 658 FLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
            +DA+  Y    + IYF+L  +V S   +NL L +I   F
Sbjct: 363 VMDAHSFY----NFIYFILLIIVGSFFMINLCLVVIATQF 398



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 52/233 (22%), Positives = 105/233 (45%), Gaps = 32/233 (13%)

Query: 118  WEPPCGLTESVEV---LCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWT- 173
            ++ P  L E++++   +  ++F  +   K   FG+  F ++ W    L ++++S++  T 
Sbjct: 1610 YQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITL 1669

Query: 174  ----VSLSLVCHEPL----RIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAI 225
                V+ SL  +  +    R+ R+ R   LL+ +  M+  L  +  +LP++ ++GLL  +
Sbjct: 1670 EEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFML 1729

Query: 226  HLCLFTMFGMLLFAGGKQDDGQDRE---RLTYFQNLPESLTSLLVLLTTAN----NPDVM 278
               +F   G+ LF   + D+    E   R   F+N   +  +L  + T  N      D +
Sbjct: 1730 LFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1789

Query: 279  IPAYSKNRAY-----AIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTS 326
                 ++  Y      I+F+ F +     L+N++ A+        LMK L+ S
Sbjct: 1790 RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV--------LMKHLEES 1834



 Score = 37.7 bits (86), Expect = 0.040
 Identities = 26/122 (21%), Positives = 57/122 (46%), Gaps = 3/122 (2%)

Query: 122 CGLTESVEVLCLLVFAADLSVKGY---LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSL 178
           C + ++ +      FA ++ VK     +FG   +  + W      +++  ++++++ L  
Sbjct: 114 CRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN 173

Query: 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
           V    +R  R+LRP   +     M+  +  +  +LP + +V LL      +F + G+ L+
Sbjct: 174 VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233

Query: 239 AG 240
           AG
Sbjct: 234 AG 235



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 17/62 (27%), Positives = 33/62 (53%), Gaps = 1/62 (1%)

Query: 255 FQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-IFFIVFTVIGSLFLMNLLTAIIYS 313
           F N+  +  ++  ++T     D+M      +  Y  I+FI+  ++GS F++NL   +I +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 396

Query: 314 QF 315
           QF
Sbjct: 397 QF 398


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.327    0.141    0.440 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,388,717
Number of Sequences: 37866
Number of extensions: 1156286
Number of successful extensions: 5187
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 81
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 3751
Number of HSP's gapped (non-prelim): 712
length of query: 752
length of database: 18,247,518
effective HSP length: 110
effective length of query: 642
effective length of database: 14,082,258
effective search space: 9040809636
effective search space used: 9040809636
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.