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Search of human proteins with 156104876
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor
[Homo sapiens]
(1338 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 2699 0.0
gi|229892300 fms-related tyrosine kinase 1 isoform 3 precursor [... 1425 0.0
gi|229892220 fms-related tyrosine kinase 1 isoform 2 precursor [... 1322 0.0
gi|229892302 fms-related tyrosine kinase 1 isoform 4 precursor [... 1049 0.0
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 1039 0.0
gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [... 924 0.0
gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [... 924 0.0
gi|5453870 platelet-derived growth factor receptor alpha precurs... 377 e-104
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 372 e-102
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 372 e-102
gi|27262659 colony stimulating factor 1 receptor precursor [Homo... 361 2e-99
gi|4505683 platelet-derived growth factor receptor beta precurso... 341 3e-93
gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens] 338 3e-92
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 324 4e-88
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 322 1e-87
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 321 3e-87
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 321 3e-87
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 321 3e-87
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 321 3e-87
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 321 3e-87
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 321 3e-87
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 320 6e-87
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 320 6e-87
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 320 8e-87
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 318 2e-86
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 318 2e-86
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 318 3e-86
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 312 1e-84
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 311 3e-84
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 310 6e-84
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 2699 bits (6995), Expect = 0.0
Identities = 1338/1338 (100%), Positives = 1338/1338 (100%)
Query: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK
Sbjct: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
Query: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET
Sbjct: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
Query: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD
Sbjct: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
Query: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV
Sbjct: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
Query: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK
Sbjct: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
Query: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK
Sbjct: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
Query: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA
Sbjct: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
Query: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC
Sbjct: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
Query: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK
Sbjct: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
Query: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM
Sbjct: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
Query: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEA 660
HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEA
Sbjct: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEA 660
Query: 661 PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIER 720
PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIER
Sbjct: 661 PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIER 720
Query: 721 VTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFI 780
VTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFI
Sbjct: 721 VTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFI 780
Query: 781 RKMKRSSSEIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGK 840
RKMKRSSSEIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGK
Sbjct: 781 RKMKRSSSEIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGK 840
Query: 841 VVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTK 900
VVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTK
Sbjct: 841 VVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTK 900
Query: 901 QGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSV 960
QGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSV
Sbjct: 901 QGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSV 960
Query: 961 TSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIH 1020
TSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIH
Sbjct: 961 TSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIH 1020
Query: 1021 RDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKS 1080
RDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKS
Sbjct: 1021 RDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKS 1080
Query: 1081 DVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRD 1140
DVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRD
Sbjct: 1081 DVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRD 1140
Query: 1141 PKERPRFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGFTYSTPAFSEDFFKESISA 1200
PKERPRFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGFTYSTPAFSEDFFKESISA
Sbjct: 1141 PKERPRFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGFTYSTPAFSEDFFKESISA 1200
Query: 1201 PKFNSGSSDDVRYVNAFKFMSLERIKTFEELLPNATSMFDDYQGDSSTLLASPMLKRFTW 1260
PKFNSGSSDDVRYVNAFKFMSLERIKTFEELLPNATSMFDDYQGDSSTLLASPMLKRFTW
Sbjct: 1201 PKFNSGSSDDVRYVNAFKFMSLERIKTFEELLPNATSMFDDYQGDSSTLLASPMLKRFTW 1260
Query: 1261 TDSKPKASLKIDLRVTSKSKESGLSDVSRPSFCHSSCGHVSEGKRRFTYDHAELERKIAC 1320
TDSKPKASLKIDLRVTSKSKESGLSDVSRPSFCHSSCGHVSEGKRRFTYDHAELERKIAC
Sbjct: 1261 TDSKPKASLKIDLRVTSKSKESGLSDVSRPSFCHSSCGHVSEGKRRFTYDHAELERKIAC 1320
Query: 1321 CSPPPDYNSVVLYSTPPI 1338
CSPPPDYNSVVLYSTPPI
Sbjct: 1321 CSPPPDYNSVVLYSTPPI 1338
>gi|229892300 fms-related tyrosine kinase 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 1425 bits (3689), Expect = 0.0
Identities = 706/715 (98%), Positives = 708/715 (99%)
Query: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK
Sbjct: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
Query: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET
Sbjct: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
Query: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD
Sbjct: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
Query: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV
Sbjct: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
Query: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK
Sbjct: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
Query: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK
Sbjct: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
Query: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA
Sbjct: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
Query: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC
Sbjct: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
Query: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK
Sbjct: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
Query: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM
Sbjct: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
Query: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEA 660
HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEA
Sbjct: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEA 660
Query: 661 PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSST 715
PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEP + S+
Sbjct: 661 PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTSTSPSS 715
Score = 49.7 bits (117), Expect = 2e-05
Identities = 50/169 (29%), Positives = 69/169 (40%), Gaps = 19/169 (11%)
Query: 570 GEDLKLSCTVNKFLYRDV--TWILLRTVNNR-TMHYSISKQKMAITKEHSITLNLTIMNV 626
G L L+CT L V TW N R ++ I + +S+ LTI +
Sbjct: 245 GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSV---LTIDKM 301
Query: 627 SLQDSGTYACRARN------VYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTL 680
+D G Y CR R+ V T I K IT++ ++ L TVA S L
Sbjct: 302 QNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVL------ETVAGKRSYRL 355
Query: 681 DCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVY 729
P P++ W K+ ++ L G S L I+ VTEED G Y
Sbjct: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYS-LIIKDVTEEDAGNY 403
Score = 34.3 bits (77), Expect = 0.82
Identities = 58/277 (20%), Positives = 108/277 (38%), Gaps = 45/277 (16%)
Query: 504 SITQRMAIIEGKNKMAS-TLVVADSRISGIYIC----IASNKVGTVGRNISFYITDVPNG 558
SIT+ GK ++ TL A + +G Y C + ++K I +I+D
Sbjct: 75 SITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRP 134
Query: 559 FHVNLEKMP-----TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITK 613
F ++P TEG +L + C V ++T T+ + I K I
Sbjct: 135 FVEMYSEIPEIIHMTEGRELVIPCRVTS---PNITV----TLKKFPLDTLIPDGKRIIWD 187
Query: 614 EHSITLNLTIMNVSLQDSGTYACRAR---NVYTGEEILQKKEITIRDQE--APYLLRNLS 668
I N + ++ G C A ++Y + ++ TI D + P ++ L
Sbjct: 188 SRK---GFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLR 244
Query: 669 DHTVAISSSTTLDCHANGVPEPQITWF---KNNHKIQQEPGIILGPGSSTLF-----IER 720
HT+ ++ + T + Q+TW + N + I + +F I++
Sbjct: 245 GHTLVLNCTATTPLNTR----VQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
Query: 721 VTEEDEGVYHC--------KATNQKGSVESSAYLTVQ 749
+ +D+G+Y C K+ N + A++TV+
Sbjct: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVK 337
>gi|229892220 fms-related tyrosine kinase 1 isoform 2 precursor
[Homo sapiens]
Length = 687
Score = 1322 bits (3422), Expect = 0.0
Identities = 656/658 (99%), Positives = 657/658 (99%)
Query: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK
Sbjct: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
Query: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET
Sbjct: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
Query: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD
Sbjct: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
Query: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV
Sbjct: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
Query: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK
Sbjct: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
Query: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK
Sbjct: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
Query: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA
Sbjct: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
Query: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC
Sbjct: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
Query: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK
Sbjct: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
Query: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM
Sbjct: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
Query: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQ 658
HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIR +
Sbjct: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRGE 658
Score = 49.7 bits (117), Expect = 2e-05
Identities = 50/169 (29%), Positives = 69/169 (40%), Gaps = 19/169 (11%)
Query: 570 GEDLKLSCTVNKFLYRDV--TWILLRTVNNR-TMHYSISKQKMAITKEHSITLNLTIMNV 626
G L L+CT L V TW N R ++ I + +S+ LTI +
Sbjct: 245 GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSV---LTIDKM 301
Query: 627 SLQDSGTYACRARN------VYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTL 680
+D G Y CR R+ V T I K IT++ ++ L TVA S L
Sbjct: 302 QNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVL------ETVAGKRSYRL 355
Query: 681 DCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVY 729
P P++ W K+ ++ L G S L I+ VTEED G Y
Sbjct: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYS-LIIKDVTEEDAGNY 403
Score = 34.3 bits (77), Expect = 0.82
Identities = 58/277 (20%), Positives = 108/277 (38%), Gaps = 45/277 (16%)
Query: 504 SITQRMAIIEGKNKMAS-TLVVADSRISGIYIC----IASNKVGTVGRNISFYITDVPNG 558
SIT+ GK ++ TL A + +G Y C + ++K I +I+D
Sbjct: 75 SITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRP 134
Query: 559 FHVNLEKMP-----TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITK 613
F ++P TEG +L + C V ++T T+ + I K I
Sbjct: 135 FVEMYSEIPEIIHMTEGRELVIPCRVTS---PNITV----TLKKFPLDTLIPDGKRIIWD 187
Query: 614 EHSITLNLTIMNVSLQDSGTYACRAR---NVYTGEEILQKKEITIRDQE--APYLLRNLS 668
I N + ++ G C A ++Y + ++ TI D + P ++ L
Sbjct: 188 SRK---GFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLR 244
Query: 669 DHTVAISSSTTLDCHANGVPEPQITWF---KNNHKIQQEPGIILGPGSSTLF-----IER 720
HT+ ++ + T + Q+TW + N + I + +F I++
Sbjct: 245 GHTLVLNCTATTPLNTR----VQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
Query: 721 VTEEDEGVYHC--------KATNQKGSVESSAYLTVQ 749
+ +D+G+Y C K+ N + A++TV+
Sbjct: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVK 337
>gi|229892302 fms-related tyrosine kinase 1 isoform 4 precursor
[Homo sapiens]
Length = 541
Score = 1049 bits (2713), Expect = 0.0
Identities = 517/518 (99%), Positives = 518/518 (100%)
Query: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK
Sbjct: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
Query: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET
Sbjct: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
Query: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD
Sbjct: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
Query: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV
Sbjct: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
Query: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK
Sbjct: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
Query: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK
Sbjct: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
Query: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA
Sbjct: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
Query: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC
Sbjct: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
Query: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKM 518
DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNK+
Sbjct: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKL 518
Score = 49.7 bits (117), Expect = 2e-05
Identities = 50/169 (29%), Positives = 69/169 (40%), Gaps = 19/169 (11%)
Query: 570 GEDLKLSCTVNKFLYRDV--TWILLRTVNNR-TMHYSISKQKMAITKEHSITLNLTIMNV 626
G L L+CT L V TW N R ++ I + +S+ LTI +
Sbjct: 245 GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSV---LTIDKM 301
Query: 627 SLQDSGTYACRARN------VYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTL 680
+D G Y CR R+ V T I K IT++ ++ L TVA S L
Sbjct: 302 QNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVL------ETVAGKRSYRL 355
Query: 681 DCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVY 729
P P++ W K+ ++ L G S L I+ VTEED G Y
Sbjct: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYS-LIIKDVTEEDAGNY 403
Score = 34.3 bits (77), Expect = 0.82
Identities = 58/277 (20%), Positives = 108/277 (38%), Gaps = 45/277 (16%)
Query: 504 SITQRMAIIEGKNKMAS-TLVVADSRISGIYIC----IASNKVGTVGRNISFYITDVPNG 558
SIT+ GK ++ TL A + +G Y C + ++K I +I+D
Sbjct: 75 SITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRP 134
Query: 559 FHVNLEKMP-----TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITK 613
F ++P TEG +L + C V ++T T+ + I K I
Sbjct: 135 FVEMYSEIPEIIHMTEGRELVIPCRVTS---PNITV----TLKKFPLDTLIPDGKRIIWD 187
Query: 614 EHSITLNLTIMNVSLQDSGTYACRAR---NVYTGEEILQKKEITIRDQE--APYLLRNLS 668
I N + ++ G C A ++Y + ++ TI D + P ++ L
Sbjct: 188 SRK---GFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLR 244
Query: 669 DHTVAISSSTTLDCHANGVPEPQITWF---KNNHKIQQEPGIILGPGSSTLF-----IER 720
HT+ ++ + T + Q+TW + N + I + +F I++
Sbjct: 245 GHTLVLNCTATTPLNTR----VQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
Query: 721 VTEEDEGVYHC--------KATNQKGSVESSAYLTVQ 749
+ +D+G+Y C K+ N + A++TV+
Sbjct: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVK 337
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 1039 bits (2687), Expect = 0.0
Identities = 603/1342 (44%), Positives = 819/1342 (61%), Gaps = 57/1342 (4%)
Query: 9 VLLCALLSCLLLTGSSSGS---KLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPE 65
+L AL C+ +S G L P LS++ ++A TL + CRG+ W P
Sbjct: 6 LLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPN 65
Query: 66 MVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIY 125
S +R+ +T+ + G FC TLT+ N TG Y C Y ++ + S IY
Sbjct: 66 NQSGSEQRVEVTECSDGL----FCKTLTIPKVIGNDTGAYKCFY------RETDLASVIY 115
Query: 126 IFISDTGRPFVEMYSEIPEIIHMTEGRE--LVIPCRVTSPNITVTL-KKFPLDTLIPDGK 182
+++ D PF+ S+ ++++TE + +VIPC + N+ V+L ++P +PDG
Sbjct: 116 VYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGN 175
Query: 183 RIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKT-NYLTHRQTNTIIDVQISTPRPVK 241
RI WDS+KGF I + G++ CEA +N Y++ Y+ I DV +S ++
Sbjct: 176 RISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIE 235
Query: 242 LLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRI--DQSNSHANIFYSVLTID 299
L G LVLNCTA T LN + W YP K++ + R QS S F S LTID
Sbjct: 236 LSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTID 295
Query: 300 KMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKV 359
+ D+GLYTC SG K +T V +++K F+ + ++E G+R R+ K
Sbjct: 296 GVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGER-VRIPAKY 354
Query: 360 KAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLT 419
+P PE+ W K+G+P +S + G+ L I +V+E D GNYT++L+ S ++
Sbjct: 355 LGYPPPEIKWYKNGIPL--ESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHV 412
Query: 420 ATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPT-IKWFWH---PCNHNH 475
+L+V V PQI EK++ S D Y G+ Q LTCT Y IP P I W+W C +
Sbjct: 413 VSLVVYVPPQIGEKSLISPVDS--YQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEP 470
Query: 476 SEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYIC 535
S+A E + D GN+IE + A+IEGKNK STLV+ + +S +Y C
Sbjct: 471 SQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKC 530
Query: 536 IASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRT- 594
A NKVG R ISF++T P + + PTE E + L CT ++ + ++TW L
Sbjct: 531 EAVNKVGRGERVISFHVTRGPE-ITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQ 589
Query: 595 ---VNNRTMHYSISKQ-----KMAITKEHSITLNLTIM---NVSLQDSGTYACRARNVYT 643
++ + + K K+ T + T ++ IM N SLQD G Y C A++ T
Sbjct: 590 PLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKT 649
Query: 644 GEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQ 703
+ +++T+ ++ AP + NL + T +I S + C A+G P PQI WFK+N + +
Sbjct: 650 KKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVE 709
Query: 704 EPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLELITLT 763
+ GI+L G+ L I RV +EDEG+Y C+A + G + A+ ++G +K+NLE+I L
Sbjct: 710 DSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILV 769
Query: 764 CTCVAATLFWLLLTLFIRKMKRSSS-EIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEF 822
T V A FWLLL + +R +KR++ E+KT YLSI+MDPDE+PLDE CERLPYDASKWEF
Sbjct: 770 GTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEF 829
Query: 823 ARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKIL 882
R+RLKLGK LGRGAFG+V++A AFGI K+ TCRTVAVKMLKEGAT SE++ALM+ELKIL
Sbjct: 830 PRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKIL 889
Query: 883 THIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKK 942
HIGHHLNVVNLLGACTK GGPLMVIVE+CK+GNLS YL+SKR+ F K K
Sbjct: 890 IHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGK 949
Query: 943 EKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISY 1002
+ + + K RLDS+TSS+S ASSGF E+KSLSDVEEEE + YK+ +T+E LI Y
Sbjct: 950 DYVG-AIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICY 1008
Query: 1003 SFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLP 1062
SFQVA+GMEFL+SRKCIHRDLAARNILLSE NVVKICDFGLARDIYK+PDYVRKGD RLP
Sbjct: 1009 SFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLP 1068
Query: 1063 LKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAP 1122
LKWMAPE+IFD++Y+ +SDVWS+GVLLWEIFSLG SPYPGV++DE+FC RL+EG RMRAP
Sbjct: 1069 LKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAP 1128
Query: 1123 EYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDGKDYI--PINAILT--G 1178
+Y+TPE+YQ MLDCWH +P +RP F+ELVE LG+LLQAN QQDGKDYI PI+ L+
Sbjct: 1129 DYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEE 1188
Query: 1179 NSGFTYSTPAFSEDFFKESISAPKFNSGSSDDV-RYVNAFKFMSLE-RIKTFEEL---LP 1233
+SG + T S +E + PKF+ ++ + +Y+ K S +KTFE++ P
Sbjct: 1189 DSGLSLPTSPVS-CMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEP 1247
Query: 1234 NATSMFDDYQGDSSTLLASPMLKRFTWTDSKPKASLKIDLRVTSKSKESGLSDVSRPSFC 1293
+ DD Q DS +LAS LK + + K S V SKS+ES S+ S +
Sbjct: 1248 EVKVIPDDNQTDSGMVLASEELKTL---EDRTKLSPSFGGMVPSKSRESVASEGSNQTSG 1304
Query: 1294 HSSCGHVSEGKRRFTYDHAELE 1315
+ S G+ S+ Y E E
Sbjct: 1305 YQS-GYHSDDTDTTVYSSEEAE 1325
>gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [Homo
sapiens]
Length = 1363
Score = 924 bits (2389), Expect = 0.0
Identities = 530/1300 (40%), Positives = 749/1300 (57%), Gaps = 77/1300 (5%)
Query: 8 GVLLCALL-SCL-LLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWS--- 62
G LC L CL LL G SG + P L++ H++ G +L + CRG+ +W+
Sbjct: 4 GAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPG 63
Query: 63 ---LPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKE 119
P K+SE + + G + + +C L L+ AN TG Y C Y + +
Sbjct: 64 AQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGT 123
Query: 120 TESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIP 179
T ++ Y+F+ D +PF+ P+ + + + +PC V+ P + VTL+ L P
Sbjct: 124 TAASSYVFVRDFEQPFINK----PDTLLVNRKDAMWVPCLVSIPGLNVTLRS-QSSVLWP 178
Query: 180 DGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTN-YLTHRQTNTIIDVQISTPR 238
DG+ ++WD R+G ++S + L CE T + +N +L H N + D+Q+ +
Sbjct: 179 DGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRK 238
Query: 239 PVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRAS--VRRRIDQSNSHANIFYSVL 296
++LL G LVLNCT N+ V W YP ++ +R RR Q+++ + S+L
Sbjct: 239 SLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELS---SIL 295
Query: 297 TIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLS 356
TI + D G Y C+ +G +T V +++ FI+V+ K +LE AG +L
Sbjct: 296 TIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLP 355
Query: 357 MKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFK 416
+K+ A+P PE W KDG + + + + +L++K+VTE G YT+ L + + +
Sbjct: 356 VKLAAYPPPEFQWYKDGKALSGRHSPH-----ALVLKEVTEASTGTYTLALWNSAAGLRR 410
Query: 417 NLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP-TIKWFWHPCNHNH 475
N++ L+VNV PQI+EK SS P++Y SRQ LTCTAYG+P P +I+W W P
Sbjct: 411 NISLELVVNVPPQIHEKEASS---PSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCK 467
Query: 476 SEARCDFCSNNEESFILDA-------DSNMGNRIESITQRMAIIEGKNKMASTLVVADSR 528
A+ ++ + + N IES+ +EGKNK S LV+ ++
Sbjct: 468 MFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNAN 527
Query: 529 ISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTE----GEDLKLSCTVNKFLY 584
+S +Y C+ SNKVG R I FY+T +P+GF +E P+E G+ + LSC + + Y
Sbjct: 528 VSAMYKCVVSNKVGQDERLIYFYVTTIPDGF--TIESKPSEELLEGQPVLLSCQADSYKY 585
Query: 585 RDVTWILLRTVNNRTMH-----------------YSISKQKMAITKEHSITLNLTIMNVS 627
+ W L H + S +++A H+ TL+L+I V+
Sbjct: 586 EHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHA-TLSLSIPRVA 644
Query: 628 LQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGV 687
+ G Y C ++ + ++ KK ++++ EAP L +NL+D V +S S + C G
Sbjct: 645 PEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGA 704
Query: 688 PEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLT 747
P I W+K+ ++++ G+ L + L I+RV EED G Y C N KG V SSA +
Sbjct: 705 HAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVA 764
Query: 748 VQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKMKRSS-SEIKTDYLSIIMDPDEVPL 806
V+G+ DK ++E++ L T V A FW+LL L M+R + ++IKT YLSIIMDP EVPL
Sbjct: 765 VEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPL 824
Query: 807 DEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEG 866
+EQCE L YDAS+WEF RERL LG+ LG GAFGKVV+ASAFGI K +C TVAVKMLKEG
Sbjct: 825 EEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEG 884
Query: 867 ATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRD 926
ATASE++ALM+ELKIL HIG+HLNVVNLLGACTK GPLMVIVE+CKYGNLSN+L++KRD
Sbjct: 885 ATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRD 944
Query: 927 LFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDS 986
F A ++ + +E + R +S + + + ++++
Sbjct: 945 AF---SPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEA 1001
Query: 987 DGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARD 1046
+ + P+TMEDL+ YSFQVARGMEFL+SRKCIHRDLAARNILLSE++VVKICDFGLARD
Sbjct: 1002 EDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARD 1061
Query: 1047 IYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMD 1106
IYK+PDYVRKG RLPLKWMAPESIFDK+Y+T+SDVWS+GVLLWEIFSLG SPYPGVQ++
Sbjct: 1062 IYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQIN 1121
Query: 1107 EDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDG 1166
E+FC RLR+G RMRAPE +TP I +IML+CW DPK RP F+ELVE LGDLLQ Q+
Sbjct: 1122 EEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEE 1181
Query: 1167 KD--YIPINAILTGNSGFTYSTPAFSEDFFKESISAPKFNSGSSDDVRYVNAFKF----- 1219
++ P ++ + F+ + ++ +P S RY N F
Sbjct: 1182 EEVCMAPRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLA 1241
Query: 1220 -----MSLERIKTFEE--LLPNATSMFDDYQGDSSTLLAS 1252
R+KTFEE + P D Q DS +LAS
Sbjct: 1242 RGAETRGSSRMKTFEEFPMTPTTYKGSVDNQTDSGMVLAS 1281
>gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [Homo
sapiens]
Length = 1298
Score = 924 bits (2389), Expect = 0.0
Identities = 530/1300 (40%), Positives = 749/1300 (57%), Gaps = 77/1300 (5%)
Query: 8 GVLLCALL-SCL-LLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWS--- 62
G LC L CL LL G SG + P L++ H++ G +L + CRG+ +W+
Sbjct: 4 GAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPG 63
Query: 63 ---LPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKE 119
P K+SE + + G + + +C L L+ AN TG Y C Y + +
Sbjct: 64 AQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGT 123
Query: 120 TESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIP 179
T ++ Y+F+ D +PF+ P+ + + + +PC V+ P + VTL+ L P
Sbjct: 124 TAASSYVFVRDFEQPFINK----PDTLLVNRKDAMWVPCLVSIPGLNVTLRS-QSSVLWP 178
Query: 180 DGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTN-YLTHRQTNTIIDVQISTPR 238
DG+ ++WD R+G ++S + L CE T + +N +L H N + D+Q+ +
Sbjct: 179 DGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRK 238
Query: 239 PVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRAS--VRRRIDQSNSHANIFYSVL 296
++LL G LVLNCT N+ V W YP ++ +R RR Q+++ + S+L
Sbjct: 239 SLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELS---SIL 295
Query: 297 TIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLS 356
TI + D G Y C+ +G +T V +++ FI+V+ K +LE AG +L
Sbjct: 296 TIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLP 355
Query: 357 MKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFK 416
+K+ A+P PE W KDG + + + + +L++K+VTE G YT+ L + + +
Sbjct: 356 VKLAAYPPPEFQWYKDGKALSGRHSPH-----ALVLKEVTEASTGTYTLALWNSAAGLRR 410
Query: 417 NLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP-TIKWFWHPCNHNH 475
N++ L+VNV PQI+EK SS P++Y SRQ LTCTAYG+P P +I+W W P
Sbjct: 411 NISLELVVNVPPQIHEKEASS---PSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCK 467
Query: 476 SEARCDFCSNNEESFILDA-------DSNMGNRIESITQRMAIIEGKNKMASTLVVADSR 528
A+ ++ + + N IES+ +EGKNK S LV+ ++
Sbjct: 468 MFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNAN 527
Query: 529 ISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTE----GEDLKLSCTVNKFLY 584
+S +Y C+ SNKVG R I FY+T +P+GF +E P+E G+ + LSC + + Y
Sbjct: 528 VSAMYKCVVSNKVGQDERLIYFYVTTIPDGF--TIESKPSEELLEGQPVLLSCQADSYKY 585
Query: 585 RDVTWILLRTVNNRTMH-----------------YSISKQKMAITKEHSITLNLTIMNVS 627
+ W L H + S +++A H+ TL+L+I V+
Sbjct: 586 EHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHA-TLSLSIPRVA 644
Query: 628 LQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGV 687
+ G Y C ++ + ++ KK ++++ EAP L +NL+D V +S S + C G
Sbjct: 645 PEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGA 704
Query: 688 PEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLT 747
P I W+K+ ++++ G+ L + L I+RV EED G Y C N KG V SSA +
Sbjct: 705 HAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVA 764
Query: 748 VQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKMKRSS-SEIKTDYLSIIMDPDEVPL 806
V+G+ DK ++E++ L T V A FW+LL L M+R + ++IKT YLSIIMDP EVPL
Sbjct: 765 VEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPL 824
Query: 807 DEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEG 866
+EQCE L YDAS+WEF RERL LG+ LG GAFGKVV+ASAFGI K +C TVAVKMLKEG
Sbjct: 825 EEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEG 884
Query: 867 ATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRD 926
ATASE++ALM+ELKIL HIG+HLNVVNLLGACTK GPLMVIVE+CKYGNLSN+L++KRD
Sbjct: 885 ATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRD 944
Query: 927 LFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDS 986
F A ++ + +E + R +S + + + ++++
Sbjct: 945 AF---SPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEA 1001
Query: 987 DGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARD 1046
+ + P+TMEDL+ YSFQVARGMEFL+SRKCIHRDLAARNILLSE++VVKICDFGLARD
Sbjct: 1002 EDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARD 1061
Query: 1047 IYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMD 1106
IYK+PDYVRKG RLPLKWMAPESIFDK+Y+T+SDVWS+GVLLWEIFSLG SPYPGVQ++
Sbjct: 1062 IYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQIN 1121
Query: 1107 EDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDG 1166
E+FC RLR+G RMRAPE +TP I +IML+CW DPK RP F+ELVE LGDLLQ Q+
Sbjct: 1122 EEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEE 1181
Query: 1167 KD--YIPINAILTGNSGFTYSTPAFSEDFFKESISAPKFNSGSSDDVRYVNAFKF----- 1219
++ P ++ + F+ + ++ +P S RY N F
Sbjct: 1182 EEVCMAPRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLA 1241
Query: 1220 -----MSLERIKTFEE--LLPNATSMFDDYQGDSSTLLAS 1252
R+KTFEE + P D Q DS +LAS
Sbjct: 1242 RGAETRGSSRMKTFEEFPMTPTTYKGSVDNQTDSGMVLAS 1281
>gi|5453870 platelet-derived growth factor receptor alpha precursor
[Homo sapiens]
Length = 1089
Score = 377 bits (967), Expect = e-104
Identities = 305/1006 (30%), Positives = 473/1006 (47%), Gaps = 145/1006 (14%)
Query: 228 TIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNS 287
++I Q+S P + + LN + + +++W YP + + + V R +++NS
Sbjct: 19 SLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNS 78
Query: 288 HANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIY------DKAFITVKHRKQ 341
+F +VL + GLYTC + ++ HIY D AF+ +
Sbjct: 79 --GLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDY 136
Query: 342 QVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAG 401
V+ V S + + +P + +G+ +R +G++ G
Sbjct: 137 LVI--VEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSR---QGFN-----------G 180
Query: 402 NYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPD------PALYPLGSRQILTCT 455
+T+ I ++ V T+ NV Y +S D +Y G ++TC
Sbjct: 181 TFTVGPYICEATVKGKKFQTIPFNV----YALKATSELDLEMEALKTVYKSGETIVVTCA 236
Query: 456 AYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGK 515
+ ++W + E + + EE ++ SI
Sbjct: 237 VFNNEVVDLQWTYP------GEVKGKGITMLEEI-----------KVPSI---------- 269
Query: 516 NKMASTLVVADSRI--SGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDL 573
K+ TL V ++ + SG Y C A V I+ GF + ++ ++ E +
Sbjct: 270 -KLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGF-IEIKPTFSQLEAV 327
Query: 574 KLS------CTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLN--LTIMN 625
L V + ++W+ NN T+ ++++ + K I L ++
Sbjct: 328 NLHEVKHFVVEVRAYPPPRISWLK----NNLTLIENLTEITTDVEKIQEIRYRSKLKLIR 383
Query: 626 VSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHAN 685
+DSG Y A+N E+ ++ + Q +L + DH + + T+ C A
Sbjct: 384 AKEEDSGHYTIVAQN----EDAVKSYTFELLTQVPSSILDLVDDHHGS-TGGQTVRCTAE 438
Query: 686 GVPEPQITWF--KNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESS 743
G P P I W K+ K E + + + I + D + T K +
Sbjct: 439 GTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIA 498
Query: 744 AYLTVQGTSDKSNLELITLTCTC-----VAATLFWLLLTLFIRKM-------KRSSSEIK 791
+ N EL + T VAA + LL+ + I + ++ EI+
Sbjct: 499 VRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIR 558
Query: 792 TDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKK 851
+ I + +LPYD S+WEF R+ L LG+ LG GAFGKVV+ +A+G+ +
Sbjct: 559 WRVIESISPDGHEYIYVDPMQLPYD-SRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSR 617
Query: 852 SPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEY 911
S VAVKMLK A +SE +ALM+ELKI+TH+G HLN+VNLLGACTK G P+ +I EY
Sbjct: 618 SQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSG-PIYIITEY 676
Query: 912 CKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSE--SFASS 969
C YG+L NYL RD F L P+K K E + G P +S S SF ++
Sbjct: 677 CFYGDLVNYLHKNRDSF-------LSHHPEKPKKELDIF-GLNPADESTRSYVILSFENN 728
Query: 970 GFQEDKSLSD-------VEEEE------------DSDGFYK------------------E 992
G D +D +E +E D YK E
Sbjct: 729 GDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSE 788
Query: 993 PITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPD 1052
+T+ DL+S+++QVARGMEFL+S+ C+HRDLAARN+LL++ +VKICDFGLARDI + +
Sbjct: 789 GLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSN 848
Query: 1053 YVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSR 1112
YV KG T LP+KWMAPESIFD +Y+T SDVWSYG+LLWEIFSLGG+PYPG+ +D F ++
Sbjct: 849 YVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNK 908
Query: 1113 LREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLL 1158
++ G RM P+++T E+Y+IM+ CW+ +P++RP F L E + +LL
Sbjct: 909 IKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
Score = 147 bits (370), Expect = 9e-35
Identities = 155/557 (27%), Positives = 242/557 (43%), Gaps = 74/557 (13%)
Query: 14 LLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKESER 73
+L CLL S +L P + + ++Q + L+C GE+ W P M +ES
Sbjct: 10 VLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP-MSEEESSD 68
Query: 74 LSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGR 133
+ I N F + L +++A A HTG Y+C Y T + + IYI++ D
Sbjct: 69 VEIRNEE--NNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDV 126
Query: 134 PFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFI 193
FV + ++ + + +IPCR T P VTL + ++P +DSR+GF
Sbjct: 127 AFVPL-GMTDYLVIVEDDDSAIIPCRTTDPETPVTLHN--SEGVVPAS----YDSRQGF- 178
Query: 194 ISNATYKEIGLLTCEATVNGHLYKT---NYLTHRQTNTIIDVQISTPRPVKLLRGHTLVL 250
N T+ +G CEATV G ++T N + T+ +D+++ + V G T+V+
Sbjct: 179 --NGTF-TVGPYICEATVKGKKFQTIPFNVYALKATSE-LDLEMEALKTV-YKSGETIVV 233
Query: 251 NCTATTPLNTRVQMTWSYPDE-KNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLY 309
C N V + W+YP E K K ++ I + + Y+ LT+ + KD G Y
Sbjct: 234 TCAVFN--NEVVDLQWTYPGEVKGKGITMLEEIKVPS--IKLVYT-LTVPEATVKDSGDY 288
Query: 310 TCRVRSG----PSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSP 365
C R K V SVH +K FI +K Q LE V ++V+A+P P
Sbjct: 289 ECAARQATREVKEMKKVTISVH--EKGFIEIKPTFSQ-LEAVNLHEVKHFVVEVRAYPPP 345
Query: 366 EVVWLKDGLPATEKSARYLT----------RGYSLIIKDVTEEDAGNYTILLSIKQSNVF 415
+ WLK+ L E T R +I+ EED+G+YTI+ + +
Sbjct: 346 RISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIR-AKEEDSGHYTIV--AQNEDAV 402
Query: 416 KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNH 475
K+ T L+ V I + + Q + CTA G P P I+W C
Sbjct: 403 KSYTFELLTQVPSSILDLVDDH------HGSTGGQTVRCTAEGTPLPDIEWM--ICK--- 451
Query: 476 SEARCDFCSNNEESFILDADSNMGNRIESITQR-MAIIEGK---NKMASTLVVADSRISG 531
+C NNE S+ + A +N+ N I I R + +EG+ K+ T+ V
Sbjct: 452 DIKKC----NNETSWTILA-NNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVR------ 500
Query: 532 IYICIASNKVGTVGRNI 548
C+A N +G R +
Sbjct: 501 ---CLAKNLLGAENREL 514
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 372 bits (956), Expect = e-102
Identities = 247/677 (36%), Positives = 366/677 (54%), Gaps = 75/677 (11%)
Query: 520 STLVVADSRI--SGIYICIASNKVGTVGRNISFYITDVPNGF-----HVNLEKMPTEGED 572
+TL ++ +R+ SG+++C A+N G+ N++ + V GF +N +GE+
Sbjct: 273 ATLTISSARVNDSGVFMCYANNTFGSA--NVTTTLEVVDKGFINIFPMINTTVFVNDGEN 330
Query: 573 LKLSCTVNKFLYRD-VTWILL-RTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQD 630
+ L F + WI + RT ++ Y S+ + I + L+LT + + +
Sbjct: 331 VDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNI--RYVSELHLTRLKGT--E 386
Query: 631 SGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEP 690
GTY N I + + + Y D V + L C A G PEP
Sbjct: 387 GGTYTFLVSNSDVNAAIAFNVYVNTKPEILTY------DRLV----NGMLQCVAAGFPEP 436
Query: 691 QITWFKNNHKIQQEPGIIL----------GPGSSTLFIERVTEED----EGVYHCKATNQ 736
I W+ Q+ +L GP L ++ + G CKA N
Sbjct: 437 TIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYND 496
Query: 737 KGSVESSAYLTVQGTSDKSNLELIT---LTCTCVAATLFWLLLTLFIRKMKRSSSEIKTD 793
G ++SAY L T + VA + +++ L + +++ E++
Sbjct: 497 VG--KTSAYFNFAFKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWK 554
Query: 794 YLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSP 853
+ I + V +D +LPYD KWEF R RL GK+LG GAFGKVV+A+A+G+ KS
Sbjct: 555 VVEEINGNNYVYIDPT--QLPYD-HKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSD 611
Query: 854 TCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCK 913
TVAVKMLK A +E +ALM+ELK+L+++G+H+N+VNLLGACT GGP +VI EYC
Sbjct: 612 AAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTI-GGPTLVITEYCC 670
Query: 914 YGNLSNYLKSKRDLFFLNK-----DAALHMEPKKEK-------------MEPGLEQGKKP 955
YG+L N+L+ KRD F +K +AAL+ K M+PG+
Sbjct: 671 YGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPT 730
Query: 956 RLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSS 1015
+ D S S + D + + +E++E + + +EDL+S+S+QVA+GM FL+S
Sbjct: 731 KADKRRSVR--IGSYIERDVTPAIMEDDELA-------LDLEDLLSFSYQVAKGMAFLAS 781
Query: 1016 RKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKI 1075
+ CIHRDLAARNILL+ + KICDFGLARDI + +YV KG+ RLP+KWMAPESIF+ +
Sbjct: 782 KNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCV 841
Query: 1076 YSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLD 1135
Y+ +SDVWSYG+ LWE+FSLG SPYPG+ +D F ++EG RM +PE++ E+Y IM
Sbjct: 842 YTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKT 901
Query: 1136 CWHRDPKERPRFAELVE 1152
CW DP +RP F ++V+
Sbjct: 902 CWDADPLKRPTFKQIVQ 918
Score = 93.2 bits (230), Expect = 1e-18
Identities = 122/500 (24%), Positives = 207/500 (41%), Gaps = 81/500 (16%)
Query: 5 WDTGVLLCALLSCLLL-TGSSSGS----KLKDPELSLKGTQHIMQAGQTLHLQCRGEAAH 59
WD LC LL L + TGSS S + P + + I++ G + L C
Sbjct: 8 WD---FLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFV 64
Query: 60 KWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKE 119
KW+ E++ + +E KQ + A+A +TG Y+C + K
Sbjct: 65 KWTF-EILDETNEN------------KQ--NEWITEKAEATNTGKYTC-------TNKHG 102
Query: 120 TESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIP 179
++IY+F+ D + F+ + ++ E + ++ C +T P +T K +P
Sbjct: 103 LSNSIYVFVRDPAKLFL-----VDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLP 157
Query: 180 DGKRIIWDSRKGFIISNA--TYKEIGLLTCEATVNGH--LYKTNYLTHRQTNTIIDVQIS 235
R I D + G +I + Y + L C G L + L R + V +S
Sbjct: 158 KDLRFIPDPKAGIMIKSVKRAYHRL-CLHCSVDQEGKSVLSEKFILKVRPAFKAVPV-VS 215
Query: 236 TPRPVKLLR-GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFY- 293
+ LLR G + CT +++ V TW +N + ++ + + S H + Y
Sbjct: 216 VSKASYLLREGEEFTVTCTIKD-VSSSVYSTWK---RENSQTKLQEKYN-SWHHGDFNYE 270
Query: 294 --SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKR 351
+ LTI + D G++ C + +V T++ + DK FI + + G+
Sbjct: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGE- 329
Query: 352 SYRLSMKVKAFPSPE-VVWLKDGLPATEKSARYLTRGYSLIIKDVTE--------EDAGN 402
+ L ++ +AFP PE W+ T+K Y I+ V+E + G
Sbjct: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGT 389
Query: 403 YTILLSIKQSNVFKNLTATLIVNVKPQI--YEKAVSSFPDPALYPLGSRQILTCTAYGIP 460
YT L+S S+V + + VN KP+I Y++ V+ +L C A G P
Sbjct: 390 YTFLVS--NSDVNAAIAFNVYVNTKPEILTYDRLVNG-------------MLQCVAAGFP 434
Query: 461 QPTIKWFWHPCNHNHSEARC 480
+PTI W++ P +E RC
Sbjct: 435 EPTIDWYFCP----GTEQRC 450
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 372 bits (956), Expect = e-102
Identities = 246/680 (36%), Positives = 367/680 (53%), Gaps = 77/680 (11%)
Query: 520 STLVVADSRI--SGIYICIASNKVGTVGRNISFYITDVPNGF-----HVNLEKMPTEGED 572
+TL ++ +R+ SG+++C A+N G+ N++ + V GF +N +GE+
Sbjct: 273 ATLTISSARVNDSGVFMCYANNTFGSA--NVTTTLEVVDKGFINIFPMINTTVFVNDGEN 330
Query: 573 LKLSCTVNKFLYRD-VTWILL-RTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQD 630
+ L F + WI + RT ++ Y S+ + I + L+LT + + +
Sbjct: 331 VDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNI--RYVSELHLTRLKGT--E 386
Query: 631 SGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEP 690
GTY N I + + + Y D V + L C A G PEP
Sbjct: 387 GGTYTFLVSNSDVNAAIAFNVYVNTKPEILTY------DRLV----NGMLQCVAAGFPEP 436
Query: 691 QITWFKNNHKIQQEPGIIL----------GPGSSTLFIERVTEED----EGVYHCKATNQ 736
I W+ Q+ +L GP L ++ + G CKA N
Sbjct: 437 TIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYND 496
Query: 737 KGSVESSAYLTVQGTSDKSNLELITLTC------TCVAATLFWLLLTLFIRKMKRSSSEI 790
G + +G ++K + TL VA + +++ L + +++ E+
Sbjct: 497 VGKTSAYFNFAFKG-NNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEV 555
Query: 791 KTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIK 850
+ + I + V +D +LPYD KWEF R RL GK+LG GAFGKVV+A+A+G+
Sbjct: 556 QWKVVEEINGNNYVYIDPT--QLPYD-HKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLI 612
Query: 851 KSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVE 910
KS TVAVKMLK A +E +ALM+ELK+L+++G+H+N+VNLLGACT GGP +VI E
Sbjct: 613 KSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTI-GGPTLVITE 671
Query: 911 YCKYGNLSNYLKSKRDLFFLNK-----DAALHMEPKKEK-------------MEPGLEQG 952
YC YG+L N+L+ KRD F +K +AAL+ K M+PG+
Sbjct: 672 YCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYV 731
Query: 953 KKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEF 1012
+ D S S + D + + +E++E + + +EDL+S+S+QVA+GM F
Sbjct: 732 VPTKADKRRSVR--IGSYIERDVTPAIMEDDELA-------LDLEDLLSFSYQVAKGMAF 782
Query: 1013 LSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIF 1072
L+S+ CIHRDLAARNILL+ + KICDFGLARDI + +YV KG+ RLP+KWMAPESIF
Sbjct: 783 LASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIF 842
Query: 1073 DKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQI 1132
+ +Y+ +SDVWSYG+ LWE+FSLG SPYPG+ +D F ++EG RM +PE++ E+Y I
Sbjct: 843 NCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDI 902
Query: 1133 MLDCWHRDPKERPRFAELVE 1152
M CW DP +RP F ++V+
Sbjct: 903 MKTCWDADPLKRPTFKQIVQ 922
Score = 93.2 bits (230), Expect = 1e-18
Identities = 122/500 (24%), Positives = 207/500 (41%), Gaps = 81/500 (16%)
Query: 5 WDTGVLLCALLSCLLL-TGSSSGS----KLKDPELSLKGTQHIMQAGQTLHLQCRGEAAH 59
WD LC LL L + TGSS S + P + + I++ G + L C
Sbjct: 8 WD---FLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFV 64
Query: 60 KWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKE 119
KW+ E++ + +E KQ + A+A +TG Y+C + K
Sbjct: 65 KWTF-EILDETNEN------------KQ--NEWITEKAEATNTGKYTC-------TNKHG 102
Query: 120 TESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIP 179
++IY+F+ D + F+ + ++ E + ++ C +T P +T K +P
Sbjct: 103 LSNSIYVFVRDPAKLFL-----VDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLP 157
Query: 180 DGKRIIWDSRKGFIISNA--TYKEIGLLTCEATVNGH--LYKTNYLTHRQTNTIIDVQIS 235
R I D + G +I + Y + L C G L + L R + V +S
Sbjct: 158 KDLRFIPDPKAGIMIKSVKRAYHRL-CLHCSVDQEGKSVLSEKFILKVRPAFKAVPV-VS 215
Query: 236 TPRPVKLLR-GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFY- 293
+ LLR G + CT +++ V TW +N + ++ + + S H + Y
Sbjct: 216 VSKASYLLREGEEFTVTCTIKD-VSSSVYSTWK---RENSQTKLQEKYN-SWHHGDFNYE 270
Query: 294 --SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKR 351
+ LTI + D G++ C + +V T++ + DK FI + + G+
Sbjct: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGE- 329
Query: 352 SYRLSMKVKAFPSPE-VVWLKDGLPATEKSARYLTRGYSLIIKDVTE--------EDAGN 402
+ L ++ +AFP PE W+ T+K Y I+ V+E + G
Sbjct: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGT 389
Query: 403 YTILLSIKQSNVFKNLTATLIVNVKPQI--YEKAVSSFPDPALYPLGSRQILTCTAYGIP 460
YT L+S S+V + + VN KP+I Y++ V+ +L C A G P
Sbjct: 390 YTFLVS--NSDVNAAIAFNVYVNTKPEILTYDRLVNG-------------MLQCVAAGFP 434
Query: 461 QPTIKWFWHPCNHNHSEARC 480
+PTI W++ P +E RC
Sbjct: 435 EPTIDWYFCP----GTEQRC 450
>gi|27262659 colony stimulating factor 1 receptor precursor [Homo
sapiens]
Length = 972
Score = 361 bits (927), Expect = 2e-99
Identities = 256/756 (33%), Positives = 383/756 (50%), Gaps = 69/756 (9%)
Query: 477 EARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVV--ADSRISGIYI 534
EA CS + D N +I Q+ + + TL + D + +G Y
Sbjct: 218 EAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYS 277
Query: 535 CIASNKVGTVGRNISFYITD---VPNGFHVNLEKMPTEGEDLKLSCTVNKFL-YRDVTWI 590
C+ASN G ++ F + + + NL + T GE L L V + + W
Sbjct: 278 CVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWT 337
Query: 591 LLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQK 650
L ++ ++ T H+ TL+L + S ++G Y+ ARN G
Sbjct: 338 YLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPS--EAGRYSFLARN--PGGWRALT 393
Query: 651 KEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFK-NNHKIQQEPGIIL 709
E+T+R ++ I+ S TL C A+G P+P +TW + + H + + +L
Sbjct: 394 FELTLRYPPEVSVIWTF------INGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVL 447
Query: 710 GPGS------------------STLFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGT 751
S L +E T E Y C+A N GS S A++ +
Sbjct: 448 QVWDDPYPEVLSQEPFHKVTVQSLLTVE--TLEHNQTYECRAHNSVGS-GSWAFIPISAG 504
Query: 752 S-----DKSNLELITLTCTCVAATLFWLLLTLFIRKMKRSSSEIKTDYLS-------IIM 799
+ D+ + + C + A L LLL L + ++ +++ + +
Sbjct: 505 AHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFI 564
Query: 800 DPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVA 859
DP ++P +E KWEF R L+ GK+LG GAFGKVV+A+AFG+ K VA
Sbjct: 565 DPTQLPYNE----------KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVA 614
Query: 860 VKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSN 919
VKMLK A A E +ALM+ELKI++H+G H N+VNLLGACT GGP++VI EYC YG+L N
Sbjct: 615 VKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACT-HGGPVLVITEYCCYGDLLN 673
Query: 920 YLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKK-PRLDSVTSSESFASSGFQEDKSLS 978
+L+ K + L + +P+ + KK R DS SS+ + S S
Sbjct: 674 FLRRKAEAM-LGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTS 732
Query: 979 --DVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVV 1036
D E+D D P+ + DL+ +S QVA+GM FL+S+ CIHRD+AARN+LL+ +V
Sbjct: 733 SNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA 792
Query: 1037 KICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLG 1096
KI DFGLARDI + +Y+ KG+ RLP+KWMAPESIFD +Y+ +SDVWSYG+LLWEIFSLG
Sbjct: 793 KIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLG 852
Query: 1097 GSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGD 1156
+PYPG+ ++ F +++G +M P ++ IY IM CW +P RP F +++
Sbjct: 853 LNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTF----QQICS 908
Query: 1157 LLQANVQQDGKDYIPINAILTGNSGFTYSTPAFSED 1192
LQ Q+D ++ N + SG + S+ + E+
Sbjct: 909 FLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEE 944
Score = 65.5 bits (158), Expect = 3e-10
Identities = 97/459 (21%), Positives = 186/459 (40%), Gaps = 66/459 (14%)
Query: 42 IMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANH 101
+++ G T+ L+C G + +W P S ++ S L+ N A +
Sbjct: 31 VVKPGATVTLRCVGNGSVEWDGPP-----SPHWTLYSDGSS-------SILSTNNATFQN 78
Query: 102 TGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVT 161
TG Y C P +AI++++ D RP+ + E+ + E ++ ++PC +T
Sbjct: 79 TGTYRCTEPGDPLGGS----AAIHLYVKDPARPWNVLAQEVV----VFEDQDALLPCLLT 130
Query: 162 SPNIT--VTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTN 219
P + V+L + L+ + GF I A + + C A + G +
Sbjct: 131 DPVLEAGVSLVRVRGRPLMRH-TNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSI 189
Query: 220 YLTHRQTNTIIDVQISTPRPVKL--LRGHTLVLNCTATTPLNTRVQMTWS-YPDEKNKRA 276
+ + I T P +L +RG + C+A++ V + + + N +
Sbjct: 190 SIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASS-----VDVNFDVFLQHNNTKL 244
Query: 277 SVRRRIDQSNSHANIFYSVLTI--DKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFI 334
++ + QS+ H N + VLT+ D++ + G Y+C + S + + + A++
Sbjct: 245 AIPQ---QSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYL 301
Query: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVV-W-----LKDGLP------ATEKSAR 382
+ + + E G+ L + V+A+P + W D P AT K
Sbjct: 302 NLSSEQNLIQEVTVGE-GLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTY 360
Query: 383 YLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPA 442
T ++L + + +AG Y+ L + ++ LT L + P++ + +F
Sbjct: 361 RHT--FTLSLPRLKPSEAGRYSFLA--RNPGGWRALTFELTLRYPPEV--SVIWTF---- 410
Query: 443 LYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD 481
+ L C A G PQP + W C+ H++ RCD
Sbjct: 411 ---INGSGTLLCAASGYPQPNVTWL--QCS-GHTD-RCD 442
>gi|4505683 platelet-derived growth factor receptor beta precursor
[Homo sapiens]
Length = 1106
Score = 341 bits (874), Expect = 3e-93
Identities = 243/717 (33%), Positives = 369/717 (51%), Gaps = 66/717 (9%)
Query: 499 GNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNG 558
G +E +T + + + + A+ SG Y C + V + IT V +G
Sbjct: 255 GRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESG 314
Query: 559 FHVNLEKMPT-EGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSI 617
+ L ++ T + +L S T+ +L +NRT+ S + + T+ S
Sbjct: 315 YVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSE 374
Query: 618 TL---NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAI 674
T LT++ V + ++G Y RA + ++ + +I + P + LS+ +
Sbjct: 375 TRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINV-----PVRVLELSE-SHPD 428
Query: 675 SSSTTLDCHANGVPEPQITWF--KNNHKIQQE-PGIILGPGS---STLFIERVTEEDEGV 728
S T+ C G+P+P I W ++ + +E P +LG S S L E+E
Sbjct: 429 SGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQE 488
Query: 729 YHCKATNQKGSVES--SAYLTVQGTSDKSNLELITLT------CTCVAATLFWLLLT--- 777
+ +T + V+ S T++ + E+I + ++A L ++LT
Sbjct: 489 FEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIIS 548
Query: 778 ---LFIRKMKRSSSEIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLG 834
L + K+ EI+ + + + +LPYD S WE R++L LG++LG
Sbjct: 549 LIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYD-STWELPRDQLVLGRTLG 607
Query: 835 RGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNL 894
GAFG+VV+A+A G+ S VAVKMLK A +SE +ALM+ELKI++H+G HLNVVNL
Sbjct: 608 SGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNL 667
Query: 895 LGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKK 954
LGACTK GGP+ +I EYC+YG+L +YL + F L + P E L G
Sbjct: 668 LGACTK-GGPIYIITEYCRYGDLVDYLHRNKHTF-LQHHSDKRRPPSAELYSNALPVGLP 725
Query: 955 -PRLDSVTSSESFASSGFQEDKSLS---------DVEEEEDSDGFYKEP----------- 993
P S+T +D+S+ DV+ + Y P
Sbjct: 726 LPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPER 785
Query: 994 ------------ITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDF 1041
++ DL+ +S+QVA GMEFL+S+ C+HRDLAARN+L+ E +VKICDF
Sbjct: 786 TCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDF 845
Query: 1042 GLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYP 1101
GLARDI ++ +Y+ KG T LPLKWMAPESIF+ +Y+T SDVWS+G+LLWEIF+LGG+PYP
Sbjct: 846 GLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYP 905
Query: 1102 GVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLL 1158
+ M+E F + ++ G RM P +++ EIY+IM CW + RP F++LV L LL
Sbjct: 906 ELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLL 962
Score = 108 bits (269), Expect = 4e-23
Identities = 127/478 (26%), Positives = 205/478 (42%), Gaps = 62/478 (12%)
Query: 8 GVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMV 67
G LL L LL S G + P G + ++ T L C G A W E +
Sbjct: 14 GELLLLSLLLLLEPQISQGLVVTPP-----GPELVLNVSSTFVLTCSGSAPVVW---ERM 65
Query: 68 SKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESA--IY 125
S+E + + A ++G F S LTL TG Y C + S+ ET+ +Y
Sbjct: 66 SQEPPQ----EMAKAQDGT-FSSVLTLTNLTGLDTGEYFCTH---NDSRGLETDERKRLY 117
Query: 126 IFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRII 185
IF+ D F+ +E I +TE E+ IPCRVT P + VTL + D +P +
Sbjct: 118 IFVPDPTVGFLPNDAE-ELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALP----VP 172
Query: 186 WDSRKGF--IISNATYKEIGLLTCEATVNGHLYKTN-YLTHRQTNTIIDVQISTPRPVKL 242
+D ++GF I + +Y C+ T+ ++ Y +R + I+V ++ + V +
Sbjct: 173 YDHQRGFSGIFEDRSY------ICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTV-V 225
Query: 243 LRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQ 302
+G + L C N V W+YP +++ R V D S+L I +
Sbjct: 226 RQGENITLMCIVIG--NEVVNFEWTYPRKESGRL-VEPVTDFLLDMPYHIRSILHIPSAE 282
Query: 303 NKDKGLYTCRVRSG----PSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMK 358
+D G YTC V K++N + + + ++ + + L+ RS L +
Sbjct: 283 LEDSGTYTCNVTESVNDHQDEKAIN--ITVVESGYVRLL-GEVGTLQFAELHRSRTLQVV 339
Query: 359 VKAFPSPEVVWLKDGLPATEKSARYL---TRGYS-------LIIKDVTEEDAGNYTILLS 408
+A+P P V+W KD + SA + TR S L + V +AG+YT+
Sbjct: 340 FEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAF 399
Query: 409 IKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
+ + V L+ L +NV ++ E + S +P Q + C G+PQP I W
Sbjct: 400 HEDAEV--QLSFQLQINVPVRVLELSES-------HPDSGEQTVRCRGRGMPQPNIIW 448
>gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens]
Length = 993
Score = 338 bits (866), Expect = 3e-92
Identities = 213/518 (41%), Positives = 299/518 (57%), Gaps = 49/518 (9%)
Query: 672 VAISSSTTLDCHANGVPEPQITWFKNNHKIQQ-----EPGI--------ILGP--GSSTL 716
+A +S++ C ++G P P TW K + K G+ + G SSTL
Sbjct: 442 LAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTL 501
Query: 717 FIERVTEEDEG-VYHCKATNQKGSVESSAYLTVQGTSD--KSNLELITLTCTCVAATLFW 773
++E +G + C A N G+ + L G + N+ C+ LF
Sbjct: 502 ---NMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCL---LFI 555
Query: 774 LLLTLFI----RKMKRSSSEIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKL 829
++LTL I +K R S+++ ++ D + +D + YD KWEF RE L+
Sbjct: 556 VVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFR--EYEYDL-KWEFPRENLEF 612
Query: 830 GKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHL 889
GK LG GAFGKV+ A+A+GI K+ VAVKMLKE A +SE +ALM+ELK++T +G H
Sbjct: 613 GKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHE 672
Query: 890 NVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFF-----LNKDAALHMEPKKEK 944
N+VNLLGACT G P+ +I EYC YG+L NYL+SKR+ F + K+ P +
Sbjct: 673 NIVNLLGACTLSG-PIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQS 731
Query: 945 MEPGLEQGKK-----PRLDSVTS--SESFASSGFQEDKSLSDVEEEEDSDGFYKEPITME 997
G + P D ++ SF S E ++ +EEEED + +T E
Sbjct: 732 HPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLN-----VLTFE 786
Query: 998 DLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKG 1057
DL+ +++QVA+GMEFL + C+HRDLAARN+L++ VVKICDFGLARDI + +YV +G
Sbjct: 787 DLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRG 846
Query: 1058 DTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGM 1117
+ RLP+KWMAPES+F+ IY+ KSDVWSYG+LLWEIFSLG +PYPG+ +D +F ++ G
Sbjct: 847 NARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGF 906
Query: 1118 RMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLG 1155
+M P Y+T EIY IM CW D ++RP F L LG
Sbjct: 907 KMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLG 944
Score = 44.3 bits (103), Expect = 8e-04
Identities = 69/326 (21%), Positives = 112/326 (34%), Gaps = 60/326 (18%)
Query: 245 GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNK 304
G L + C A +N +TW ++ + + S + I + +
Sbjct: 265 GEPLWIRCKAVH-VNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARN 323
Query: 305 DKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPS 364
D G YTC PS ++ V I +K FI + + + + S++ KA+P
Sbjct: 324 DTGYYTCSSSKHPSQSAL---VTIVEKGFINATNSSEDY--EIDQYEEFCFSVRFKAYPQ 378
Query: 365 PEVVWL--KDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATL 422
W + P +K L GYS+ + G Y + K TL
Sbjct: 379 IRCTWTFSRKSFPCEQKG---LDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMF--TL 433
Query: 423 IVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDF 482
+ KPQ+ +A S +C + G P P+ W W C+ D
Sbjct: 434 NIRRKPQVLAEA-------------SASQASCFSDGYPLPS--WTWKKCS--------DK 470
Query: 483 CSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVG 542
N E + NR + G+ +STL ++++ + C A N +G
Sbjct: 471 SPNCTEEITEGVWNRKANR---------KVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLG 521
Query: 543 T---------------VGRNISFYIT 553
T + NISFY T
Sbjct: 522 TSCETILLNSPGPFPFIQDNISFYAT 547
Score = 31.2 bits (69), Expect = 7.0
Identities = 17/78 (21%), Positives = 36/78 (46%), Gaps = 8/78 (10%)
Query: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGS 448
S++I +TE AG Y + + + +N T++ V I + + P + +
Sbjct: 127 SMVILKMTETQAGEYLLFIQSEATNY------TILFTVS--IRNTLLYTLRRPYFRKMEN 178
Query: 449 RQILTCTAYGIPQPTIKW 466
+ L C + +P+P ++W
Sbjct: 179 QDALVCISESVPEPIVEW 196
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 324 bits (830), Expect = 4e-88
Identities = 224/632 (35%), Positives = 313/632 (49%), Gaps = 118/632 (18%)
Query: 621 LTIMNVSLQDSGTYACRARNVYT-----------------GEEILQKKEITIRDQEAPYL 663
L ++N S +DSG Y+CR R E+ + E T D APY
Sbjct: 94 LQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYW 153
Query: 664 LR--NLSDHTVAISSSTTLD--CHANGVPEPQITWFKNNHKIQQEP---GIILGPGSSTL 716
R + +A+ ++ T+ C A G P P I+W KN + + E GI L +L
Sbjct: 154 TRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSL 213
Query: 717 FIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDK-----------------SNLEL 759
+E V D G Y C N+ GS+ + L V S S++E
Sbjct: 214 VMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEF 273
Query: 760 ITLTCTCVAATLFWL-----------------LLTLFIRKMKRSSSEIKTDYLSII-MDP 801
+ + WL + L + +S T + I +
Sbjct: 274 HCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSS 333
Query: 802 DEVPLDEQCERLPYDAS-KWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR--TV 858
E P L A KWE +R RL LGK LG G FG+VV A A GI K + TV
Sbjct: 334 GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTV 393
Query: 859 AVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLS 918
AVKMLK+ AT + L++E++++ IG H N++NLLGACT QGGPL V+VEY GNL
Sbjct: 394 AVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QGGPLYVLVEYAAKGNLR 452
Query: 919 NYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLS 978
+L+++R PGL D S
Sbjct: 453 EFLRARRP--------------------PGL------------------------DYSFD 468
Query: 979 DVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKI 1038
+ E E +T +DL+S ++QVARGME+L+S+KCIHRDLAARN+L++E+NV+KI
Sbjct: 469 TCKPPE-------EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKI 521
Query: 1039 CDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGS 1098
DFGLARD++ Y + + RLP+KWMAPE++FD++Y+ +SDVWS+GVLLWEIF+LGGS
Sbjct: 522 ADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGS 581
Query: 1099 PYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLL 1158
PYPG+ ++E F L+EG RM P T ++Y IM +CWH P +RP F +LVE L +L
Sbjct: 582 PYPGIPVEELF-KLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVL 640
Query: 1159 QANVQQDGKDYIPINAILTGNSGFTYSTPAFS 1190
+Y+ ++A S TP+ S
Sbjct: 641 TVT---STDEYLDLSAPFEQYSPGGQDTPSSS 669
Score = 43.5 bits (101), Expect = 0.001
Identities = 34/141 (24%), Positives = 57/141 (40%), Gaps = 10/141 (7%)
Query: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEK----SARYLTRGYSL 390
T R + L V + R P+P + WLK+G + + + +SL
Sbjct: 154 TRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSL 213
Query: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
+++ V D GNYT ++ N F ++ T ++V + + + + P LGS
Sbjct: 214 VMESVVPSDRGNYTCVV----ENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGS 269
Query: 449 RQILTCTAYGIPQPTIKWFWH 469
C Y QP I+W H
Sbjct: 270 DVEFHCKVYSDAQPHIQWLKH 290
>gi|222144233 fibroblast growth factor receptor 2 isoform 4 precursor
[Homo sapiens]
Length = 709
Score = 322 bits (826), Expect = 1e-87
Identities = 218/625 (34%), Positives = 309/625 (49%), Gaps = 134/625 (21%)
Query: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEIT----------------------IRDQ 658
L I + +DSG YAC A E +T ++
Sbjct: 92 LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNK 151
Query: 659 EAPYLLRNLSD----HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEP---GIILGP 711
APY H V +++ C A G P P + W KN + +QE G +
Sbjct: 152 RAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRN 211
Query: 712 GSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNL----ELITLTCTCV 767
+L +E V D+G Y C N+ GS+ + +L V + + + + + C+
Sbjct: 212 QHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPGREKEITASPDYLEIAIYCI 271
Query: 768 AATLF-WLLLTLFIRKMKRSSSEIKTDYLS---IIMDPDEVPLDEQCE------------ 811
L +++T+ + +MK ++ K D+ S + +PL Q
Sbjct: 272 GVFLIACMVVTVILCRMKNTTK--KPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSN 329
Query: 812 -------------------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASA 846
LP D KWEF R++L LGK LG G FG+VV A A
Sbjct: 330 TPLVRITTRLSSTADTPMLAGVSEYELPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEA 388
Query: 847 FGIKKSPTCR--TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGP 904
GI K TVAVKMLK+ AT + L++E++++ IG H N++NLLGACT Q GP
Sbjct: 389 VGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGP 447
Query: 905 LMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSE 964
L VIVEY GNL YL+++R PG+E
Sbjct: 448 LYVIVEYASKGNLREYLRARRP--------------------PGMEYSY----------- 476
Query: 965 SFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLA 1024
++ V EE+ +T +DL+S ++Q+ARGME+L+S+KCIHRDLA
Sbjct: 477 -----------DINRVPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLA 516
Query: 1025 ARNILLSENNVVKICDFGLARDIYKNPDYVRKGDT-RLPLKWMAPESIFDKIYSTKSDVW 1083
ARN+L++ENNV+KI DFGLARDI N DY +K RLP+KWMAPE++FD++Y+ +SDVW
Sbjct: 517 ARNVLVTENNVMKIADFGLARDI-NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 575
Query: 1084 SYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKE 1143
S+GVL+WEIF+LGGSPYPG+ ++E F L+EG RM P T E+Y +M DCWH P +
Sbjct: 576 SFGVLMWEIFTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 634
Query: 1144 RPRFAELVEKLGDLLQANVQQDGKD 1168
RP F +LVE L +L ++ D
Sbjct: 635 RPTFKQLVEDLDRILTLTTNEEYLD 659
Score = 35.8 bits (81), Expect = 0.28
Identities = 30/120 (25%), Positives = 53/120 (44%), Gaps = 11/120 (9%)
Query: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRG--YSL 390
T + ++ L V + + P P + WLK+G + Y R +SL
Sbjct: 157 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPD---PALYPLG 447
I++ V D GNYT ++ N + ++ T ++V EK +++ PD A+Y +G
Sbjct: 217 IMESVVPSDKGNYTCVV----ENEYGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIG 272
>gi|222144241 fibroblast growth factor receptor 2 isoform 8 precursor
[Homo sapiens]
Length = 704
Score = 321 bits (823), Expect = 3e-87
Identities = 217/612 (35%), Positives = 307/612 (50%), Gaps = 120/612 (19%)
Query: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISSST 678
+L + +V D G Y C N Y ++ R P L L ++ + +
Sbjct: 100 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 159
Query: 679 TLDCHANGVPEPQITWFKNNHKIQQEPG--------IILGPGSST-------LFIERVTE 723
C +P I W K+ K + G ++ G +T L+I VT
Sbjct: 160 EFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTF 219
Query: 724 EDEGVYHCKATNQKGSVESSAYLTVQGTSDK-----SNLELITLTCTCVAATLF-WLLLT 777
ED G Y C A N G SA+LTV + ++ + + + C+ L +++T
Sbjct: 220 EDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVT 279
Query: 778 LFIRKMKRSSSEIKTDYLS---IIMDPDEVPLDEQCE----------------------- 811
+ + +MK ++ K D+ S + +PL Q
Sbjct: 280 VILCRMKNTTK--KPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSST 337
Query: 812 ------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR--T 857
LP D KWEF R++L LGK LG G FG+VV A A GI K T
Sbjct: 338 ADTPMLAGVSEYELPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVT 396
Query: 858 VAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNL 917
VAVKMLK+ AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY GNL
Sbjct: 397 VAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNL 455
Query: 918 SNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSL 977
YL+++R PG+E +
Sbjct: 456 REYLRARRP--------------------PGMEYSY----------------------DI 473
Query: 978 SDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVK 1037
+ V EE+ +T +DL+S ++Q+ARGME+L+S+KCIHRDLAARN+L++ENNV+K
Sbjct: 474 NRVPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMK 524
Query: 1038 ICDFGLARDIYKNPDYVRKGDT-RLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLG 1096
I DFGLARDI N DY +K RLP+KWMAPE++FD++Y+ +SDVWS+GVL+WEIF+LG
Sbjct: 525 IADFGLARDI-NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLG 583
Query: 1097 GSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGD 1156
GSPYPG+ ++E F L+EG RM P T E+Y +M DCWH P +RP F +LVE L
Sbjct: 584 GSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 642
Query: 1157 LLQANVQQDGKD 1168
+L ++ D
Sbjct: 643 ILTLTTNEEYLD 654
Score = 45.8 bits (107), Expect = 3e-04
Identities = 29/105 (27%), Positives = 47/105 (44%), Gaps = 7/105 (6%)
Query: 651 KEITIRDQEAPYLLRNLSD----HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE-- 704
++ T+ + APY H V +++ C A G P P + W KN + +QE
Sbjct: 29 EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88
Query: 705 -PGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTV 748
G + +L +E V D+G Y C N+ GS+ + +L V
Sbjct: 89 IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDV 133
Score = 43.1 bits (100), Expect = 0.002
Identities = 38/160 (23%), Positives = 66/160 (41%), Gaps = 11/160 (6%)
Query: 317 PSFKSV-NTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG-- 373
PSF V +T++ + T + ++ L V + + P P + WLK+G
Sbjct: 23 PSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKE 82
Query: 374 LPATEKSARYLTRG--YSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIY 431
+ Y R +SLI++ V D GNYT ++ N + ++ T ++V +
Sbjct: 83 FKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV----ENEYGSINHTYHLDVVERSP 138
Query: 432 EKAV--SSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWH 469
+ + + P A +G C Y QP I+W H
Sbjct: 139 HRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKH 178
Score = 34.3 bits (77), Expect = 0.82
Identities = 47/179 (26%), Positives = 75/179 (41%), Gaps = 37/179 (20%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE--------TV 347
L ++ + DKG YTC V + + S+N + H+ + + + +L+ TV
Sbjct: 101 LIMESVVPSDKGNYTCVVEN--EYGSINHTYHLD----VVERSPHRPILQAGLPANASTV 154
Query: 348 AGKRSYRLSMKVKAFPSPEVVWLK-----------DGLPATE--KSARYLTRGYS---LI 391
G KV + P + W+K DGLP + K+A T L
Sbjct: 155 VGG-DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLY 213
Query: 392 IKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPD---PALYPLG 447
I++VT EDAG YT L F + T++ EK +++ PD A+Y +G
Sbjct: 214 IRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL---PAPGREKEITASPDYLEIAIYCIG 269
>gi|222144235 fibroblast growth factor receptor 2 isoform 5 precursor
[Homo sapiens]
Length = 707
Score = 321 bits (822), Expect = 3e-87
Identities = 217/613 (35%), Positives = 307/613 (50%), Gaps = 122/613 (19%)
Query: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISSST 678
+L + +V D G Y C N Y ++ R P L L ++ + +
Sbjct: 126 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 185
Query: 679 TLDCHANGVPEPQITWFKNNHKIQQEPG--------IILGPGSST-------LFIERVTE 723
C +P I W K+ K + G ++ G +T L+I VT
Sbjct: 186 EFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTF 245
Query: 724 EDEGVYHCKATNQKGSVESSAYLTVQGTSDK-----SNLELITLTCTCVAATLF-WLLLT 777
ED G Y C A N G SA+LTV + ++ + + + C+ L +++T
Sbjct: 246 EDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVT 305
Query: 778 LFIRKMKRSSSEIKTDYLS---IIMDPDEVPLDEQCE----------------------- 811
+ + +MK ++ K D+ S + +PL Q
Sbjct: 306 VILCRMKNTTK--KPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLS 363
Query: 812 --------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR- 856
LP D KWEF R++L LGK LG G FG+VV A A GI K
Sbjct: 364 STADTPMLAGVSEYELPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 422
Query: 857 -TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYG 915
TVAVKMLK+ AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY G
Sbjct: 423 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKG 481
Query: 916 NLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDK 975
NL YL+++R PG+E
Sbjct: 482 NLREYLRARRP--------------------PGMEYSY---------------------- 499
Query: 976 SLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNV 1035
++ V EE+ +T +DL+S ++Q+ARGME+L+S+KCIHRDLAARN+L++ENNV
Sbjct: 500 DINRVPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 550
Query: 1036 VKICDFGLARDIYKNPDYVRKGDT-RLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFS 1094
+KI DFGLARDI N DY +K RLP+KWMAPE++FD++Y+ +SDVWS+GVL+WEIF+
Sbjct: 551 MKIADFGLARDI-NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 609
Query: 1095 LGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL 1154
LGGSPYPG+ ++E F L+EG RM P T E+Y +M DCWH P +RP F +LVE L
Sbjct: 610 LGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 668
Query: 1155 GDLLQANVQQDGK 1167
+L ++ K
Sbjct: 669 DRILTLTTNEEEK 681
Score = 45.1 bits (105), Expect = 5e-04
Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 3/82 (3%)
Query: 670 HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGPGSSTLFIERVTEEDE 726
H V +++ C A G P P + W KN + +QE G + +L +E V D+
Sbjct: 78 HAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDK 137
Query: 727 GVYHCKATNQKGSVESSAYLTV 748
G Y C N+ GS+ + +L V
Sbjct: 138 GNYTCVVENEYGSINHTYHLDV 159
Score = 40.4 bits (93), Expect = 0.011
Identities = 33/141 (23%), Positives = 57/141 (40%), Gaps = 10/141 (7%)
Query: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRG--YSL 390
T + ++ L V + + P P + WLK+G + Y R +SL
Sbjct: 68 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 127
Query: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
I++ V D GNYT ++ N + ++ T ++V + + + + P A +G
Sbjct: 128 IMESVVPSDKGNYTCVV----ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 183
Query: 449 RQILTCTAYGIPQPTIKWFWH 469
C Y QP I+W H
Sbjct: 184 DVEFVCKVYSDAQPHIQWIKH 204
Score = 34.3 bits (77), Expect = 0.82
Identities = 47/179 (26%), Positives = 75/179 (41%), Gaps = 37/179 (20%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE--------TV 347
L ++ + DKG YTC V + + S+N + H+ + + + +L+ TV
Sbjct: 127 LIMESVVPSDKGNYTCVVEN--EYGSINHTYHLD----VVERSPHRPILQAGLPANASTV 180
Query: 348 AGKRSYRLSMKVKAFPSPEVVWLK-----------DGLPATE--KSARYLTRGYS---LI 391
G KV + P + W+K DGLP + K+A T L
Sbjct: 181 VGG-DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLY 239
Query: 392 IKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPD---PALYPLG 447
I++VT EDAG YT L F + T++ EK +++ PD A+Y +G
Sbjct: 240 IRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL---PAPGREKEITASPDYLEIAIYCIG 295
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 321 bits (822), Expect = 3e-87
Identities = 219/613 (35%), Positives = 307/613 (50%), Gaps = 118/613 (19%)
Query: 618 TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISS 676
T ++ + +V D G Y C N Y + ++ R P L L ++ TVA+ S
Sbjct: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 180
Query: 677 STTLDCHANGVPEPQITWFK----NNHKIQQEP----GIILGPGSST-------LFIERV 721
+ C P+P I W K N KI + I+ G +T L + V
Sbjct: 181 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 240
Query: 722 TEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLEL-----ITLTCTCVAATLFWLLL 776
+ ED G Y C A N G SA+LTV ++ + + + C A L ++
Sbjct: 241 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 300
Query: 777 -TLFIRKMKRSSSEIKTDY---LSIIMDPDEVPLDEQCE--------------------- 811
++ + KMK + K+D+ +++ +PL Q
Sbjct: 301 GSVIVYKMKSGTK--KSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL 358
Query: 812 --------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRT 857
LP D +WE R+RL LGK LG G FG+VV A A G+ K R
Sbjct: 359 SSSGTPMLAGVSEYELPEDP-RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 417
Query: 858 --VAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYG 915
VAVKMLK AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY G
Sbjct: 418 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKG 476
Query: 916 NLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDK 975
NL YL+++R PGLE P +
Sbjct: 477 NLREYLQARRP--------------------PGLEYCYNPSHNP---------------- 500
Query: 976 SLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNV 1035
+E ++ +DL+S ++QVARGME+L+S+KCIHRDLAARN+L++E+NV
Sbjct: 501 ---------------EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV 545
Query: 1036 VKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSL 1095
+KI DFGLARDI+ Y + + RLP+KWMAPE++FD+IY+ +SDVWS+GVLLWEIF+L
Sbjct: 546 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL 605
Query: 1096 GGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLG 1155
GGSPYPGV ++E F L+EG RM P T E+Y +M DCWH P +RP F +LVE L
Sbjct: 606 GGSPYPGVPVEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 664
Query: 1156 DLLQANVQQDGKD 1168
++ Q+ D
Sbjct: 665 RIVALTSNQEYLD 677
Score = 47.4 bits (111), Expect = 9e-05
Identities = 35/143 (24%), Positives = 59/143 (41%), Gaps = 14/143 (9%)
Query: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEK------SARYLTRGY 388
T + ++ L V ++ + P+P + WLK+G RY T +
Sbjct: 65 TSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT--W 122
Query: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPL 446
S+I+ V D GNYT ++ N + ++ T ++V + + + + P L
Sbjct: 123 SIIMDSVVPSDKGNYTCIVE----NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 178
Query: 447 GSRQILTCTAYGIPQPTIKWFWH 469
GS C Y PQP I+W H
Sbjct: 179 GSNVEFMCKVYSDPQPHIQWLKH 201
Score = 40.8 bits (94), Expect = 0.009
Identities = 20/82 (24%), Positives = 38/82 (46%), Gaps = 3/82 (3%)
Query: 670 HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGPGSSTLFIERVTEEDE 726
H V + + C ++G P P + W KN + + + G + + ++ ++ V D+
Sbjct: 75 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 134
Query: 727 GVYHCKATNQKGSVESSAYLTV 748
G Y C N+ GS+ + L V
Sbjct: 135 GNYTCIVENEYGSINHTYQLDV 156
Score = 35.0 bits (79), Expect = 0.48
Identities = 38/134 (28%), Positives = 59/134 (44%), Gaps = 29/134 (21%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE-------TVA 348
+ +D + DKG YTC V + + S+N H Y + + + + +L+ TVA
Sbjct: 124 IIMDSVVPSDKGNYTCIVEN--EYGSIN---HTY-QLDVVERSPHRPILQAGLPANKTVA 177
Query: 349 GKRSYRLSMKVKAFPSPEVVWLK-----------DGLPATE--KSARYLTRGYS---LII 392
+ KV + P P + WLK D LP + K+A T L +
Sbjct: 178 LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHL 237
Query: 393 KDVTEEDAGNYTIL 406
++V+ EDAG YT L
Sbjct: 238 RNVSFEDAGEYTCL 251
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 321 bits (822), Expect = 3e-87
Identities = 219/613 (35%), Positives = 307/613 (50%), Gaps = 118/613 (19%)
Query: 618 TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISS 676
T ++ + +V D G Y C N Y + ++ R P L L ++ TVA+ S
Sbjct: 123 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 182
Query: 677 STTLDCHANGVPEPQITWFK----NNHKIQQEP----GIILGPGSST-------LFIERV 721
+ C P+P I W K N KI + I+ G +T L + V
Sbjct: 183 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 242
Query: 722 TEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLEL-----ITLTCTCVAATLFWLLL 776
+ ED G Y C A N G SA+LTV ++ + + + C A L ++
Sbjct: 243 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 302
Query: 777 -TLFIRKMKRSSSEIKTDY---LSIIMDPDEVPLDEQCE--------------------- 811
++ + KMK + K+D+ +++ +PL Q
Sbjct: 303 GSVIVYKMKSGTK--KSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL 360
Query: 812 --------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRT 857
LP D +WE R+RL LGK LG G FG+VV A A G+ K R
Sbjct: 361 SSSGTPMLAGVSEYELPEDP-RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 419
Query: 858 --VAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYG 915
VAVKMLK AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY G
Sbjct: 420 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKG 478
Query: 916 NLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDK 975
NL YL+++R PGLE P +
Sbjct: 479 NLREYLQARRP--------------------PGLEYCYNPSHNP---------------- 502
Query: 976 SLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNV 1035
+E ++ +DL+S ++QVARGME+L+S+KCIHRDLAARN+L++E+NV
Sbjct: 503 ---------------EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV 547
Query: 1036 VKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSL 1095
+KI DFGLARDI+ Y + + RLP+KWMAPE++FD+IY+ +SDVWS+GVLLWEIF+L
Sbjct: 548 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL 607
Query: 1096 GGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLG 1155
GGSPYPGV ++E F L+EG RM P T E+Y +M DCWH P +RP F +LVE L
Sbjct: 608 GGSPYPGVPVEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 666
Query: 1156 DLLQANVQQDGKD 1168
++ Q+ D
Sbjct: 667 RIVALTSNQEYLD 679
Score = 47.4 bits (111), Expect = 9e-05
Identities = 35/143 (24%), Positives = 59/143 (41%), Gaps = 14/143 (9%)
Query: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEK------SARYLTRGY 388
T + ++ L V ++ + P+P + WLK+G RY T +
Sbjct: 67 TSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT--W 124
Query: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPL 446
S+I+ V D GNYT ++ N + ++ T ++V + + + + P L
Sbjct: 125 SIIMDSVVPSDKGNYTCIVE----NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 180
Query: 447 GSRQILTCTAYGIPQPTIKWFWH 469
GS C Y PQP I+W H
Sbjct: 181 GSNVEFMCKVYSDPQPHIQWLKH 203
Score = 40.8 bits (94), Expect = 0.009
Identities = 20/82 (24%), Positives = 38/82 (46%), Gaps = 3/82 (3%)
Query: 670 HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGPGSSTLFIERVTEEDE 726
H V + + C ++G P P + W KN + + + G + + ++ ++ V D+
Sbjct: 77 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 136
Query: 727 GVYHCKATNQKGSVESSAYLTV 748
G Y C N+ GS+ + L V
Sbjct: 137 GNYTCIVENEYGSINHTYQLDV 158
Score = 35.0 bits (79), Expect = 0.48
Identities = 38/134 (28%), Positives = 59/134 (44%), Gaps = 29/134 (21%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE-------TVA 348
+ +D + DKG YTC V + + S+N H Y + + + + +L+ TVA
Sbjct: 126 IIMDSVVPSDKGNYTCIVEN--EYGSIN---HTY-QLDVVERSPHRPILQAGLPANKTVA 179
Query: 349 GKRSYRLSMKVKAFPSPEVVWLK-----------DGLPATE--KSARYLTRGYS---LII 392
+ KV + P P + WLK D LP + K+A T L +
Sbjct: 180 LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHL 239
Query: 393 KDVTEEDAGNYTIL 406
++V+ EDAG YT L
Sbjct: 240 RNVSFEDAGEYTCL 253
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 321 bits (822), Expect = 3e-87
Identities = 219/613 (35%), Positives = 307/613 (50%), Gaps = 118/613 (19%)
Query: 618 TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISS 676
T ++ + +V D G Y C N Y + ++ R P L L ++ TVA+ S
Sbjct: 210 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 269
Query: 677 STTLDCHANGVPEPQITWFK----NNHKIQQEP----GIILGPGSST-------LFIERV 721
+ C P+P I W K N KI + I+ G +T L + V
Sbjct: 270 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 329
Query: 722 TEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLEL-----ITLTCTCVAATLFWLLL 776
+ ED G Y C A N G SA+LTV ++ + + + C A L ++
Sbjct: 330 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 389
Query: 777 -TLFIRKMKRSSSEIKTDY---LSIIMDPDEVPLDEQCE--------------------- 811
++ + KMK + K+D+ +++ +PL Q
Sbjct: 390 GSVIVYKMKSGTK--KSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL 447
Query: 812 --------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRT 857
LP D +WE R+RL LGK LG G FG+VV A A G+ K R
Sbjct: 448 SSSGTPMLAGVSEYELPEDP-RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 506
Query: 858 --VAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYG 915
VAVKMLK AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY G
Sbjct: 507 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKG 565
Query: 916 NLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDK 975
NL YL+++R PGLE P +
Sbjct: 566 NLREYLQARRP--------------------PGLEYCYNPSHNP---------------- 589
Query: 976 SLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNV 1035
+E ++ +DL+S ++QVARGME+L+S+KCIHRDLAARN+L++E+NV
Sbjct: 590 ---------------EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV 634
Query: 1036 VKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSL 1095
+KI DFGLARDI+ Y + + RLP+KWMAPE++FD+IY+ +SDVWS+GVLLWEIF+L
Sbjct: 635 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL 694
Query: 1096 GGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLG 1155
GGSPYPGV ++E F L+EG RM P T E+Y +M DCWH P +RP F +LVE L
Sbjct: 695 GGSPYPGVPVEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 753
Query: 1156 DLLQANVQQDGKD 1168
++ Q+ D
Sbjct: 754 RIVALTSNQEYLD 766
Score = 47.4 bits (111), Expect = 9e-05
Identities = 35/143 (24%), Positives = 59/143 (41%), Gaps = 14/143 (9%)
Query: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEK------SARYLTRGY 388
T + ++ L V ++ + P+P + WLK+G RY T +
Sbjct: 154 TSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT--W 211
Query: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPL 446
S+I+ V D GNYT ++ N + ++ T ++V + + + + P L
Sbjct: 212 SIIMDSVVPSDKGNYTCIVE----NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 267
Query: 447 GSRQILTCTAYGIPQPTIKWFWH 469
GS C Y PQP I+W H
Sbjct: 268 GSNVEFMCKVYSDPQPHIQWLKH 290
Score = 40.8 bits (94), Expect = 0.009
Identities = 20/82 (24%), Positives = 38/82 (46%), Gaps = 3/82 (3%)
Query: 670 HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGPGSSTLFIERVTEEDE 726
H V + + C ++G P P + W KN + + + G + + ++ ++ V D+
Sbjct: 164 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 223
Query: 727 GVYHCKATNQKGSVESSAYLTV 748
G Y C N+ GS+ + L V
Sbjct: 224 GNYTCIVENEYGSINHTYQLDV 245
Score = 35.0 bits (79), Expect = 0.48
Identities = 38/134 (28%), Positives = 59/134 (44%), Gaps = 29/134 (21%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE-------TVA 348
+ +D + DKG YTC V + + S+N H Y + + + + +L+ TVA
Sbjct: 213 IIMDSVVPSDKGNYTCIVEN--EYGSIN---HTY-QLDVVERSPHRPILQAGLPANKTVA 266
Query: 349 GKRSYRLSMKVKAFPSPEVVWLK-----------DGLPATE--KSARYLTRGYS---LII 392
+ KV + P P + WLK D LP + K+A T L +
Sbjct: 267 LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHL 326
Query: 393 KDVTEEDAGNYTIL 406
++V+ EDAG YT L
Sbjct: 327 RNVSFEDAGEYTCL 340
>gi|105990522 fibroblast growth factor receptor 1 isoform 1 precursor
[Homo sapiens]
Length = 822
Score = 321 bits (822), Expect = 3e-87
Identities = 219/613 (35%), Positives = 307/613 (50%), Gaps = 118/613 (19%)
Query: 618 TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISS 676
T ++ + +V D G Y C N Y + ++ R P L L ++ TVA+ S
Sbjct: 212 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 271
Query: 677 STTLDCHANGVPEPQITWFK----NNHKIQQEP----GIILGPGSST-------LFIERV 721
+ C P+P I W K N KI + I+ G +T L + V
Sbjct: 272 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 331
Query: 722 TEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLEL-----ITLTCTCVAATLFWLLL 776
+ ED G Y C A N G SA+LTV ++ + + + C A L ++
Sbjct: 332 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 391
Query: 777 -TLFIRKMKRSSSEIKTDY---LSIIMDPDEVPLDEQCE--------------------- 811
++ + KMK + K+D+ +++ +PL Q
Sbjct: 392 GSVIVYKMKSGTK--KSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL 449
Query: 812 --------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRT 857
LP D +WE R+RL LGK LG G FG+VV A A G+ K R
Sbjct: 450 SSSGTPMLAGVSEYELPEDP-RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 508
Query: 858 --VAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYG 915
VAVKMLK AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY G
Sbjct: 509 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKG 567
Query: 916 NLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDK 975
NL YL+++R PGLE P +
Sbjct: 568 NLREYLQARRP--------------------PGLEYCYNPSHNP---------------- 591
Query: 976 SLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNV 1035
+E ++ +DL+S ++QVARGME+L+S+KCIHRDLAARN+L++E+NV
Sbjct: 592 ---------------EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV 636
Query: 1036 VKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSL 1095
+KI DFGLARDI+ Y + + RLP+KWMAPE++FD+IY+ +SDVWS+GVLLWEIF+L
Sbjct: 637 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL 696
Query: 1096 GGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLG 1155
GGSPYPGV ++E F L+EG RM P T E+Y +M DCWH P +RP F +LVE L
Sbjct: 697 GGSPYPGVPVEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 755
Query: 1156 DLLQANVQQDGKD 1168
++ Q+ D
Sbjct: 756 RIVALTSNQEYLD 768
Score = 47.4 bits (111), Expect = 9e-05
Identities = 35/143 (24%), Positives = 59/143 (41%), Gaps = 14/143 (9%)
Query: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEK------SARYLTRGY 388
T + ++ L V ++ + P+P + WLK+G RY T +
Sbjct: 156 TSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT--W 213
Query: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPL 446
S+I+ V D GNYT ++ N + ++ T ++V + + + + P L
Sbjct: 214 SIIMDSVVPSDKGNYTCIVE----NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 269
Query: 447 GSRQILTCTAYGIPQPTIKWFWH 469
GS C Y PQP I+W H
Sbjct: 270 GSNVEFMCKVYSDPQPHIQWLKH 292
Score = 40.8 bits (94), Expect = 0.009
Identities = 20/82 (24%), Positives = 38/82 (46%), Gaps = 3/82 (3%)
Query: 670 HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGPGSSTLFIERVTEEDE 726
H V + + C ++G P P + W KN + + + G + + ++ ++ V D+
Sbjct: 166 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 225
Query: 727 GVYHCKATNQKGSVESSAYLTV 748
G Y C N+ GS+ + L V
Sbjct: 226 GNYTCIVENEYGSINHTYQLDV 247
Score = 35.0 bits (79), Expect = 0.48
Identities = 38/134 (28%), Positives = 59/134 (44%), Gaps = 29/134 (21%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE-------TVA 348
+ +D + DKG YTC V + + S+N H Y + + + + +L+ TVA
Sbjct: 215 IIMDSVVPSDKGNYTCIVEN--EYGSIN---HTY-QLDVVERSPHRPILQAGLPANKTVA 268
Query: 349 GKRSYRLSMKVKAFPSPEVVWLK-----------DGLPATE--KSARYLTRGYS---LII 392
+ KV + P P + WLK D LP + K+A T L +
Sbjct: 269 LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHL 328
Query: 393 KDVTEEDAGNYTIL 406
++V+ EDAG YT L
Sbjct: 329 RNVSFEDAGEYTCL 342
>gi|222144237 fibroblast growth factor receptor 2 isoform 6 precursor
[Homo sapiens]
Length = 706
Score = 320 bits (820), Expect = 6e-87
Identities = 217/614 (35%), Positives = 307/614 (50%), Gaps = 122/614 (19%)
Query: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISSST 678
+L + +V D G Y C N Y ++ R P L L ++ + +
Sbjct: 100 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 159
Query: 679 TLDCHANGVPEPQITWFKNNHKIQQEPG--------IILGPGSST-------LFIERVTE 723
C +P I W K+ K + G ++ G +T L+I VT
Sbjct: 160 EFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTF 219
Query: 724 EDEGVYHCKATNQKGSVESSAYLTVQGTSDK-----SNLELITLTCTCVAATLF-WLLLT 777
ED G Y C A N G SA+LTV + ++ + + + C+ L +++T
Sbjct: 220 EDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVT 279
Query: 778 LFIRKMKRSSSEIKTDYLS---IIMDPDEVPLDEQCE----------------------- 811
+ + +MK ++ K D+ S + +PL Q
Sbjct: 280 VILCRMKNTTK--KPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLS 337
Query: 812 --------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR- 856
LP D KWEF R++L LGK LG G FG+VV A A GI K
Sbjct: 338 STADTPMLAGVSEYELPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 396
Query: 857 -TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYG 915
TVAVKMLK+ AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY G
Sbjct: 397 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKG 455
Query: 916 NLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDK 975
NL YL+++R PG+E
Sbjct: 456 NLREYLRARRP--------------------PGMEYSY---------------------- 473
Query: 976 SLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNV 1035
++ V EE+ +T +DL+S ++Q+ARGME+L+S+KCIHRDLAARN+L++ENNV
Sbjct: 474 DINRVPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 524
Query: 1036 VKICDFGLARDIYKNPDYVRKGDT-RLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFS 1094
+KI DFGLARDI N DY +K RLP+KWMAPE++FD++Y+ +SDVWS+GVL+WEIF+
Sbjct: 525 MKIADFGLARDI-NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 583
Query: 1095 LGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL 1154
LGGSPYPG+ ++E F L+EG RM P T E+Y +M DCWH P +RP F +LVE L
Sbjct: 584 LGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 642
Query: 1155 GDLLQANVQQDGKD 1168
+L ++ D
Sbjct: 643 DRILTLTTNEEYLD 656
Score = 45.8 bits (107), Expect = 3e-04
Identities = 29/105 (27%), Positives = 47/105 (44%), Gaps = 7/105 (6%)
Query: 651 KEITIRDQEAPYLLRNLSD----HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE-- 704
++ T+ + APY H V +++ C A G P P + W KN + +QE
Sbjct: 29 EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88
Query: 705 -PGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTV 748
G + +L +E V D+G Y C N+ GS+ + +L V
Sbjct: 89 IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDV 133
Score = 43.1 bits (100), Expect = 0.002
Identities = 38/160 (23%), Positives = 66/160 (41%), Gaps = 11/160 (6%)
Query: 317 PSFKSV-NTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG-- 373
PSF V +T++ + T + ++ L V + + P P + WLK+G
Sbjct: 23 PSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKE 82
Query: 374 LPATEKSARYLTRG--YSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIY 431
+ Y R +SLI++ V D GNYT ++ N + ++ T ++V +
Sbjct: 83 FKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV----ENEYGSINHTYHLDVVERSP 138
Query: 432 EKAV--SSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWH 469
+ + + P A +G C Y QP I+W H
Sbjct: 139 HRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKH 178
Score = 34.3 bits (77), Expect = 0.82
Identities = 47/179 (26%), Positives = 75/179 (41%), Gaps = 37/179 (20%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE--------TV 347
L ++ + DKG YTC V + + S+N + H+ + + + +L+ TV
Sbjct: 101 LIMESVVPSDKGNYTCVVEN--EYGSINHTYHLD----VVERSPHRPILQAGLPANASTV 154
Query: 348 AGKRSYRLSMKVKAFPSPEVVWLK-----------DGLPATE--KSARYLTRGYS---LI 391
G KV + P + W+K DGLP + K+A T L
Sbjct: 155 VGG-DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLY 213
Query: 392 IKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPD---PALYPLG 447
I++VT EDAG YT L F + T++ EK +++ PD A+Y +G
Sbjct: 214 IRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL---PAPGREKEITASPDYLEIAIYCIG 269
>gi|221316639 fibroblast growth factor receptor 2 isoform 1 precursor
[Homo sapiens]
Length = 821
Score = 320 bits (820), Expect = 6e-87
Identities = 217/614 (35%), Positives = 307/614 (50%), Gaps = 122/614 (19%)
Query: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISSST 678
+L + +V D G Y C N Y ++ R P L L ++ + +
Sbjct: 215 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274
Query: 679 TLDCHANGVPEPQITWFKNNHKIQQEPG--------IILGPGSST-------LFIERVTE 723
C +P I W K+ K + G ++ G +T L+I VT
Sbjct: 275 EFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTF 334
Query: 724 EDEGVYHCKATNQKGSVESSAYLTVQGTSDK-----SNLELITLTCTCVAATLF-WLLLT 777
ED G Y C A N G SA+LTV + ++ + + + C+ L +++T
Sbjct: 335 EDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVT 394
Query: 778 LFIRKMKRSSSEIKTDYLS---IIMDPDEVPLDEQCE----------------------- 811
+ + +MK ++ K D+ S + +PL Q
Sbjct: 395 VILCRMKNTTK--KPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLS 452
Query: 812 --------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR- 856
LP D KWEF R++L LGK LG G FG+VV A A GI K
Sbjct: 453 STADTPMLAGVSEYELPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 511
Query: 857 -TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYG 915
TVAVKMLK+ AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY G
Sbjct: 512 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKG 570
Query: 916 NLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDK 975
NL YL+++R PG+E
Sbjct: 571 NLREYLRARRP--------------------PGMEYSY---------------------- 588
Query: 976 SLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNV 1035
++ V EE+ +T +DL+S ++Q+ARGME+L+S+KCIHRDLAARN+L++ENNV
Sbjct: 589 DINRVPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 639
Query: 1036 VKICDFGLARDIYKNPDYVRKGDT-RLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFS 1094
+KI DFGLARDI N DY +K RLP+KWMAPE++FD++Y+ +SDVWS+GVL+WEIF+
Sbjct: 640 MKIADFGLARDI-NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 698
Query: 1095 LGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL 1154
LGGSPYPG+ ++E F L+EG RM P T E+Y +M DCWH P +RP F +LVE L
Sbjct: 699 LGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 757
Query: 1155 GDLLQANVQQDGKD 1168
+L ++ D
Sbjct: 758 DRILTLTTNEEYLD 771
Score = 46.2 bits (108), Expect = 2e-04
Identities = 39/157 (24%), Positives = 58/157 (36%), Gaps = 29/157 (18%)
Query: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEIT----------------------IRDQ 658
L I + +DSG YAC A E +T ++
Sbjct: 92 LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNK 151
Query: 659 EAPYLLRNLSD----HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGP 711
APY H V +++ C A G P P + W KN + +QE G +
Sbjct: 152 RAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRN 211
Query: 712 GSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTV 748
+L +E V D+G Y C N+ GS+ + +L V
Sbjct: 212 QHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDV 248
Score = 40.4 bits (93), Expect = 0.011
Identities = 33/141 (23%), Positives = 57/141 (40%), Gaps = 10/141 (7%)
Query: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRG--YSL 390
T + ++ L V + + P P + WLK+G + Y R +SL
Sbjct: 157 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
I++ V D GNYT ++ N + ++ T ++V + + + + P A +G
Sbjct: 217 IMESVVPSDKGNYTCVV----ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 272
Query: 449 RQILTCTAYGIPQPTIKWFWH 469
C Y QP I+W H
Sbjct: 273 DVEFVCKVYSDAQPHIQWIKH 293
Score = 34.3 bits (77), Expect = 0.82
Identities = 47/179 (26%), Positives = 75/179 (41%), Gaps = 37/179 (20%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE--------TV 347
L ++ + DKG YTC V + + S+N + H+ + + + +L+ TV
Sbjct: 216 LIMESVVPSDKGNYTCVVEN--EYGSINHTYHLD----VVERSPHRPILQAGLPANASTV 269
Query: 348 AGKRSYRLSMKVKAFPSPEVVWLK-----------DGLPATE--KSARYLTRGYS---LI 391
G KV + P + W+K DGLP + K+A T L
Sbjct: 270 VGG-DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLY 328
Query: 392 IKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPD---PALYPLG 447
I++VT EDAG YT L F + T++ EK +++ PD A+Y +G
Sbjct: 329 IRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL---PAPGREKEITASPDYLEIAIYCIG 384
>gi|221316638 fibroblast growth factor receptor 2 isoform 2 precursor
[Homo sapiens]
Length = 822
Score = 320 bits (819), Expect = 8e-87
Identities = 216/615 (35%), Positives = 301/615 (48%), Gaps = 123/615 (20%)
Query: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISSST 678
+L + +V D G Y C N Y ++ R P L L ++ + +
Sbjct: 215 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274
Query: 679 TLDCHANGVPEPQITWFKNNHKIQQEPGI-------------ILGPGSSTLFIERVTEED 725
C +P I W K+ K + G I + L + VTE D
Sbjct: 275 EFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEAD 334
Query: 726 EGVYHCKATNQKGSVESSAYLTVQGTSDKSNLE--------LITLTCTCVAATLF-WLLL 776
G Y CK +N G SA+LTV E + + C+ L +++
Sbjct: 335 AGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVV 394
Query: 777 TLFIRKMKRSSSEIKTDYLS---IIMDPDEVPLDEQCE---------------------- 811
T+ + +MK ++ K D+ S + +PL Q
Sbjct: 395 TVILCRMKNTTK--KPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL 452
Query: 812 ---------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR 856
LP D KWEF R++L LGK LG G FG+VV A A GI K
Sbjct: 453 SSTADTPMLAGVSEYELPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKE 511
Query: 857 --TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKY 914
TVAVKMLK+ AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY
Sbjct: 512 AVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASK 570
Query: 915 GNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQED 974
GNL YL+++R PG+E
Sbjct: 571 GNLREYLRARRP--------------------PGMEYSY--------------------- 589
Query: 975 KSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENN 1034
++ V EE+ +T +DL+S ++Q+ARGME+L+S+KCIHRDLAARN+L++ENN
Sbjct: 590 -DINRVPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN 639
Query: 1035 VVKICDFGLARDIYKNPDYVRKGDT-RLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIF 1093
V+KI DFGLARDI N DY +K RLP+KWMAPE++FD++Y+ +SDVWS+GVL+WEIF
Sbjct: 640 VMKIADFGLARDI-NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIF 698
Query: 1094 SLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEK 1153
+LGGSPYPG+ ++E F L+EG RM P T E+Y +M DCWH P +RP F +LVE
Sbjct: 699 TLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 757
Query: 1154 LGDLLQANVQQDGKD 1168
L +L ++ D
Sbjct: 758 LDRILTLTTNEEYLD 772
Score = 46.2 bits (108), Expect = 2e-04
Identities = 39/157 (24%), Positives = 58/157 (36%), Gaps = 29/157 (18%)
Query: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEIT----------------------IRDQ 658
L I + +DSG YAC A E +T ++
Sbjct: 92 LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNK 151
Query: 659 EAPYLLRNLSD----HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGP 711
APY H V +++ C A G P P + W KN + +QE G +
Sbjct: 152 RAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRN 211
Query: 712 GSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTV 748
+L +E V D+G Y C N+ GS+ + +L V
Sbjct: 212 QHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDV 248
Score = 42.0 bits (97), Expect = 0.004
Identities = 64/300 (21%), Positives = 111/300 (37%), Gaps = 36/300 (12%)
Query: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRG--YSL 390
T + ++ L V + + P P + WLK+G + Y R +SL
Sbjct: 157 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
I++ V D GNYT ++ N + ++ T ++V + + + + P A +G
Sbjct: 217 IMESVVPSDKGNYTCVV----ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 272
Query: 449 RQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQR 508
C Y QP I+W H N S+ D G + +
Sbjct: 273 DVEFVCKVYSDAQPHIQWIKH-VEKNGSKYGPD-----------------GLPYLKVLKH 314
Query: 509 MAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT 568
I ++ + V ++ +G YIC SN +G N S ++T +P EK T
Sbjct: 315 SGINSSNAEVLALFNVTEAD-AGEYICKVSNYIGQA--NQSAWLTVLPKQQAPGREKEIT 371
Query: 569 EGED---LKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMA--ITKEHSITLNLTI 623
D + + C + V ++L + N T S Q +TK + +T+
Sbjct: 372 ASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTV 431
>gi|222144244 fibroblast growth factor receptor 2 isoform 9 precursor
[Homo sapiens]
Length = 680
Score = 318 bits (816), Expect = 2e-86
Identities = 215/605 (35%), Positives = 298/605 (49%), Gaps = 123/605 (20%)
Query: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISSST 678
+L + +V D G Y C N Y ++ R P L L ++ + +
Sbjct: 126 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 185
Query: 679 TLDCHANGVPEPQITWFKNNHKIQQEPGI-------------ILGPGSSTLFIERVTEED 725
C +P I W K+ K + G I + L + VTE D
Sbjct: 186 EFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEAD 245
Query: 726 EGVYHCKATNQKGSVESSAYLTVQGTSDKSNLE--------LITLTCTCVAATLF-WLLL 776
G Y CK +N G SA+LTV E + + C+ L +++
Sbjct: 246 AGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVV 305
Query: 777 TLFIRKMKRSSSEIKTDYLS---IIMDPDEVPLDEQCE---------------------- 811
T+ + +MK ++ K D+ S + +PL Q
Sbjct: 306 TVILCRMKNTTK--KPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL 363
Query: 812 ---------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR 856
LP D KWEF R++L LGK LG G FG+VV A A GI K
Sbjct: 364 SSTADTPMLAGVSEYELPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKE 422
Query: 857 --TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKY 914
TVAVKMLK+ AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY
Sbjct: 423 AVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASK 481
Query: 915 GNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQED 974
GNL YL+++R PG+E
Sbjct: 482 GNLREYLRARRP--------------------PGMEYSY--------------------- 500
Query: 975 KSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENN 1034
++ V EE+ +T +DL+S ++Q+ARGME+L+S+KCIHRDLAARN+L++ENN
Sbjct: 501 -DINRVPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN 550
Query: 1035 VVKICDFGLARDIYKNPDYVRKGDT-RLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIF 1093
V+KI DFGLARDI N DY +K RLP+KWMAPE++FD++Y+ +SDVWS+GVL+WEIF
Sbjct: 551 VMKIADFGLARDI-NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIF 609
Query: 1094 SLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEK 1153
+LGGSPYPG+ ++E F L+EG RM P T E+Y +M DCWH P +RP F +LVE
Sbjct: 610 TLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 668
Query: 1154 LGDLL 1158
L +L
Sbjct: 669 LDRIL 673
Score = 45.1 bits (105), Expect = 5e-04
Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 3/82 (3%)
Query: 670 HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGPGSSTLFIERVTEEDE 726
H V +++ C A G P P + W KN + +QE G + +L +E V D+
Sbjct: 78 HAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDK 137
Query: 727 GVYHCKATNQKGSVESSAYLTV 748
G Y C N+ GS+ + +L V
Sbjct: 138 GNYTCVVENEYGSINHTYHLDV 159
Score = 42.0 bits (97), Expect = 0.004
Identities = 64/300 (21%), Positives = 111/300 (37%), Gaps = 36/300 (12%)
Query: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRG--YSL 390
T + ++ L V + + P P + WLK+G + Y R +SL
Sbjct: 68 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 127
Query: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
I++ V D GNYT ++ N + ++ T ++V + + + + P A +G
Sbjct: 128 IMESVVPSDKGNYTCVV----ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 183
Query: 449 RQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQR 508
C Y QP I+W H N S+ D G + +
Sbjct: 184 DVEFVCKVYSDAQPHIQWIKH-VEKNGSKYGPD-----------------GLPYLKVLKH 225
Query: 509 MAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT 568
I ++ + V ++ +G YIC SN +G N S ++T +P EK T
Sbjct: 226 SGINSSNAEVLALFNVTEAD-AGEYICKVSNYIGQA--NQSAWLTVLPKQQAPGREKEIT 282
Query: 569 EGED---LKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMA--ITKEHSITLNLTI 623
D + + C + V ++L + N T S Q +TK + +T+
Sbjct: 283 ASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTV 342
>gi|222144231 fibroblast growth factor receptor 2 isoform 3 precursor
[Homo sapiens]
Length = 769
Score = 318 bits (816), Expect = 2e-86
Identities = 215/605 (35%), Positives = 298/605 (49%), Gaps = 123/605 (20%)
Query: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISSST 678
+L + +V D G Y C N Y ++ R P L L ++ + +
Sbjct: 215 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274
Query: 679 TLDCHANGVPEPQITWFKNNHKIQQEPGI-------------ILGPGSSTLFIERVTEED 725
C +P I W K+ K + G I + L + VTE D
Sbjct: 275 EFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEAD 334
Query: 726 EGVYHCKATNQKGSVESSAYLTVQGTSDKSNLE--------LITLTCTCVAATLF-WLLL 776
G Y CK +N G SA+LTV E + + C+ L +++
Sbjct: 335 AGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVV 394
Query: 777 TLFIRKMKRSSSEIKTDYLS---IIMDPDEVPLDEQCE---------------------- 811
T+ + +MK ++ K D+ S + +PL Q
Sbjct: 395 TVILCRMKNTTK--KPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL 452
Query: 812 ---------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR 856
LP D KWEF R++L LGK LG G FG+VV A A GI K
Sbjct: 453 SSTADTPMLAGVSEYELPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKE 511
Query: 857 --TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKY 914
TVAVKMLK+ AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY
Sbjct: 512 AVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASK 570
Query: 915 GNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQED 974
GNL YL+++R PG+E
Sbjct: 571 GNLREYLRARRP--------------------PGMEYSY--------------------- 589
Query: 975 KSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENN 1034
++ V EE+ +T +DL+S ++Q+ARGME+L+S+KCIHRDLAARN+L++ENN
Sbjct: 590 -DINRVPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN 639
Query: 1035 VVKICDFGLARDIYKNPDYVRKGDT-RLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIF 1093
V+KI DFGLARDI N DY +K RLP+KWMAPE++FD++Y+ +SDVWS+GVL+WEIF
Sbjct: 640 VMKIADFGLARDI-NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIF 698
Query: 1094 SLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEK 1153
+LGGSPYPG+ ++E F L+EG RM P T E+Y +M DCWH P +RP F +LVE
Sbjct: 699 TLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 757
Query: 1154 LGDLL 1158
L +L
Sbjct: 758 LDRIL 762
Score = 46.2 bits (108), Expect = 2e-04
Identities = 39/157 (24%), Positives = 58/157 (36%), Gaps = 29/157 (18%)
Query: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEIT----------------------IRDQ 658
L I + +DSG YAC A E +T ++
Sbjct: 92 LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNK 151
Query: 659 EAPYLLRNLSD----HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGP 711
APY H V +++ C A G P P + W KN + +QE G +
Sbjct: 152 RAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRN 211
Query: 712 GSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTV 748
+L +E V D+G Y C N+ GS+ + +L V
Sbjct: 212 QHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDV 248
Score = 42.0 bits (97), Expect = 0.004
Identities = 64/300 (21%), Positives = 111/300 (37%), Gaps = 36/300 (12%)
Query: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRG--YSL 390
T + ++ L V + + P P + WLK+G + Y R +SL
Sbjct: 157 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
I++ V D GNYT ++ N + ++ T ++V + + + + P A +G
Sbjct: 217 IMESVVPSDKGNYTCVV----ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 272
Query: 449 RQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQR 508
C Y QP I+W H N S+ D G + +
Sbjct: 273 DVEFVCKVYSDAQPHIQWIKH-VEKNGSKYGPD-----------------GLPYLKVLKH 314
Query: 509 MAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT 568
I ++ + V ++ +G YIC SN +G N S ++T +P EK T
Sbjct: 315 SGINSSNAEVLALFNVTEAD-AGEYICKVSNYIGQA--NQSAWLTVLPKQQAPGREKEIT 371
Query: 569 EGED---LKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMA--ITKEHSITLNLTI 623
D + + C + V ++L + N T S Q +TK + +T+
Sbjct: 372 ASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTV 431
>gi|222144239 fibroblast growth factor receptor 2 isoform 7 precursor
[Homo sapiens]
Length = 705
Score = 318 bits (814), Expect = 3e-86
Identities = 219/618 (35%), Positives = 306/618 (49%), Gaps = 124/618 (20%)
Query: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEIT----------------------IRDQ 658
L I + +DSG YAC A E +T ++
Sbjct: 92 LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNK 151
Query: 659 EAPYLLRNLSD----HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEP---GIILGP 711
APY H V +++ C A G P P + W KN + +QE G +
Sbjct: 152 RAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRN 211
Query: 712 GSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLELITLTC---TCVA 768
+L +E V D+G Y C N+ GS+ + +L V S + L T V
Sbjct: 212 QHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVG 271
Query: 769 ATLFWLLLTL--------FIRKMKRSSSEIKTD---YLSIIMDPDE--------VPLDEQ 809
+ ++ +I+ ++++ S+ D YL ++ E PL
Sbjct: 272 GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKVSAESSSSMNSNTPLVRI 331
Query: 810 CERLPYDAS----------------KWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSP 853
RL A KWEF R++L LGK LG G FG+VV A A GI K
Sbjct: 332 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 391
Query: 854 TCR--TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEY 911
TVAVKMLK+ AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY
Sbjct: 392 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEY 450
Query: 912 CKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGF 971
GNL YL+++R PG+E
Sbjct: 451 ASKGNLREYLRARRP--------------------PGMEYSY------------------ 472
Query: 972 QEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLS 1031
++ V EE+ +T +DL+S ++Q+ARGME+L+S+KCIHRDLAARN+L++
Sbjct: 473 ----DINRVPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT 519
Query: 1032 ENNVVKICDFGLARDIYKNPDYVRKGDT-RLPLKWMAPESIFDKIYSTKSDVWSYGVLLW 1090
ENNV+KI DFGLARDI N DY +K RLP+KWMAPE++FD++Y+ +SDVWS+GVL+W
Sbjct: 520 ENNVMKIADFGLARDI-NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMW 578
Query: 1091 EIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAEL 1150
EIF+LGGSPYPG+ ++E F L+EG RM P T E+Y +M DCWH P +RP F +L
Sbjct: 579 EIFTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQL 637
Query: 1151 VEKLGDLLQANVQQDGKD 1168
VE L +L ++ D
Sbjct: 638 VEDLDRILTLTTNEEYLD 655
Score = 40.4 bits (93), Expect = 0.011
Identities = 33/141 (23%), Positives = 57/141 (40%), Gaps = 10/141 (7%)
Query: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRG--YSL 390
T + ++ L V + + P P + WLK+G + Y R +SL
Sbjct: 157 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
I++ V D GNYT ++ N + ++ T ++V + + + + P A +G
Sbjct: 217 IMESVVPSDKGNYTCVV----ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 272
Query: 449 RQILTCTAYGIPQPTIKWFWH 469
C Y QP I+W H
Sbjct: 273 DVEFVCKVYSDAQPHIQWIKH 293
>gi|254028242 fibroblast growth factor receptor 3 isoform 3 precursor
[Homo sapiens]
Length = 808
Score = 312 bits (800), Expect = 1e-84
Identities = 216/632 (34%), Positives = 307/632 (48%), Gaps = 121/632 (19%)
Query: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISSST 678
+L + +V D G Y C N + ++ R P L L ++ T + S
Sbjct: 212 SLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDV 271
Query: 679 TLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSST------------------LFIER 720
C +P I W K+ + G +GP + L +
Sbjct: 272 EFHCKVYSDAQPHIQWLKH----VEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLAN 327
Query: 721 VTEEDEGVYHCKATNQKGSVESSAYLTVQGT---------SDKSNLELITLTCTCVAATL 771
V+E D G Y C+ATN G E + +L+V G +D++ + V L
Sbjct: 328 VSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFL 387
Query: 772 FWLLLTLF-----------------IRKMKR------------SSSEIKTDYLSII-MDP 801
F L++ + K+ R +S T + I +
Sbjct: 388 FILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSS 447
Query: 802 DEVPLDEQCERLPYDAS-KWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR--TV 858
E P L A KWE +R RL LGK LG G FG+VV A A GI K + TV
Sbjct: 448 GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTV 507
Query: 859 AVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLS 918
AVKMLK+ AT + L++E++++ IG H N++NLLGACT QGGPL V+VEY GNL
Sbjct: 508 AVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QGGPLYVLVEYAAKGNLR 566
Query: 919 NYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLS 978
+L+++R PGL D S
Sbjct: 567 EFLRARRP--------------------PGL------------------------DYSFD 582
Query: 979 DVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKI 1038
+ E E +T +DL+S ++QVARGME+L+S+KCIHRDLAARN+L++E+NV+KI
Sbjct: 583 TCKPPE-------EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKI 635
Query: 1039 CDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGS 1098
DFGLARD++ Y + + RLP+KWMAPE++FD++Y+ +SDVWS+GVLLWEIF+LGGS
Sbjct: 636 ADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGS 695
Query: 1099 PYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLL 1158
PYPG+ ++E F L+EG RM P T ++Y IM +CWH P +RP F +LVE L +L
Sbjct: 696 PYPGIPVEELF-KLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVL 754
Query: 1159 QANVQQDGKDYIPINAILTGNSGFTYSTPAFS 1190
+Y+ ++A S TP+ S
Sbjct: 755 TVT---STDEYLDLSAPFEQYSPGGQDTPSSS 783
Score = 54.7 bits (130), Expect = 6e-07
Identities = 45/152 (29%), Positives = 66/152 (43%), Gaps = 24/152 (15%)
Query: 621 LTIMNVSLQDSGTYACRAR-----------------NVYTGEEILQKKEITIRDQEAPYL 663
L ++N S +DSG Y+CR R + E+ + E T D APY
Sbjct: 94 LQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYW 153
Query: 664 LR--NLSDHTVAISSSTTL--DCHANGVPEPQITWFKNNHKIQQE---PGIILGPGSSTL 716
R + +A+ ++ T+ C A G P P I+W KN + + E GI L +L
Sbjct: 154 TRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSL 213
Query: 717 FIERVTEEDEGVYHCKATNQKGSVESSAYLTV 748
+E V D G Y C N+ GS+ + L V
Sbjct: 214 VMESVVPSDRGNYTCVVENKFGSIRQTYTLDV 245
Score = 43.5 bits (101), Expect = 0.001
Identities = 34/141 (24%), Positives = 57/141 (40%), Gaps = 10/141 (7%)
Query: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEK----SARYLTRGYSL 390
T R + L V + R P+P + WLK+G + + + +SL
Sbjct: 154 TRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSL 213
Query: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
+++ V D GNYT ++ N F ++ T ++V + + + + P LGS
Sbjct: 214 VMESVVPSDRGNYTCVV----ENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGS 269
Query: 449 RQILTCTAYGIPQPTIKWFWH 469
C Y QP I+W H
Sbjct: 270 DVEFHCKVYSDAQPHIQWLKH 290
Score = 38.1 bits (87), Expect = 0.057
Identities = 29/121 (23%), Positives = 50/121 (41%), Gaps = 13/121 (10%)
Query: 531 GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTE-----GEDLKLSCTVNKFLYR 585
G Y C+ NK G++ + + + + + +P G D++ C V
Sbjct: 224 GNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQP 283
Query: 586 DVTWILLRTVNNR------TMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRAR 639
+ W+ VN T + ++ K ++ + E + L L NVS +D G Y CRA
Sbjct: 284 HIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLA--NVSERDGGEYLCRAT 341
Query: 640 N 640
N
Sbjct: 342 N 342
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 311 bits (797), Expect = 3e-84
Identities = 217/626 (34%), Positives = 306/626 (48%), Gaps = 111/626 (17%)
Query: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISSST 678
+L + +V D G Y C N + ++ R P L L ++ T + S
Sbjct: 212 SLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDV 271
Query: 679 TLDCHANGVPEPQITWFK----NNHKIQQEPG----IILGPGSST-------LFIERVTE 723
C +P I W K N K+ + ++ G++T L + VT
Sbjct: 272 EFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTF 331
Query: 724 EDEGVYHCKATNQKGSVESSAYLTVQGT------SDKSNLELITLTCTCVAATLFWLLLT 777
ED G Y C A N G SA+L V +D++ + V LF L++
Sbjct: 332 EDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVA 391
Query: 778 LF-----------------IRKMKR------------SSSEIKTDYLSII-MDPDEVPLD 807
+ K+ R +S T + I + E P
Sbjct: 392 AVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTL 451
Query: 808 EQCERLPYDAS-KWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR--TVAVKMLK 864
L A KWE +R RL LGK LG G FG+VV A A GI K + TVAVKMLK
Sbjct: 452 ANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLK 511
Query: 865 EGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSK 924
+ AT + L++E++++ IG H N++NLLGACT QGGPL V+VEY GNL +L+++
Sbjct: 512 DDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QGGPLYVLVEYAAKGNLREFLRAR 570
Query: 925 RDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEE 984
R PGL D S + E
Sbjct: 571 RP--------------------PGL------------------------DYSFDTCKPPE 586
Query: 985 DSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLA 1044
E +T +DL+S ++QVARGME+L+S+KCIHRDLAARN+L++E+NV+KI DFGLA
Sbjct: 587 -------EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLA 639
Query: 1045 RDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQ 1104
RD++ Y + + RLP+KWMAPE++FD++Y+ +SDVWS+GVLLWEIF+LGGSPYPG+
Sbjct: 640 RDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIP 699
Query: 1105 MDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQ 1164
++E F L+EG RM P T ++Y IM +CWH P +RP F +LVE L +L
Sbjct: 700 VEELF-KLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVT--- 755
Query: 1165 DGKDYIPINAILTGNSGFTYSTPAFS 1190
+Y+ ++A S TP+ S
Sbjct: 756 STDEYLDLSAPFEQYSPGGQDTPSSS 781
Score = 54.7 bits (130), Expect = 6e-07
Identities = 45/152 (29%), Positives = 66/152 (43%), Gaps = 24/152 (15%)
Query: 621 LTIMNVSLQDSGTYACRAR-----------------NVYTGEEILQKKEITIRDQEAPYL 663
L ++N S +DSG Y+CR R + E+ + E T D APY
Sbjct: 94 LQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYW 153
Query: 664 LR--NLSDHTVAISSSTTL--DCHANGVPEPQITWFKNNHKIQQE---PGIILGPGSSTL 716
R + +A+ ++ T+ C A G P P I+W KN + + E GI L +L
Sbjct: 154 TRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSL 213
Query: 717 FIERVTEEDEGVYHCKATNQKGSVESSAYLTV 748
+E V D G Y C N+ GS+ + L V
Sbjct: 214 VMESVVPSDRGNYTCVVENKFGSIRQTYTLDV 245
Score = 43.5 bits (101), Expect = 0.001
Identities = 34/141 (24%), Positives = 57/141 (40%), Gaps = 10/141 (7%)
Query: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEK----SARYLTRGYSL 390
T R + L V + R P+P + WLK+G + + + +SL
Sbjct: 154 TRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSL 213
Query: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
+++ V D GNYT ++ N F ++ T ++V + + + + P LGS
Sbjct: 214 VMESVVPSDRGNYTCVV----ENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGS 269
Query: 449 RQILTCTAYGIPQPTIKWFWH 469
C Y QP I+W H
Sbjct: 270 DVEFHCKVYSDAQPHIQWLKH 290
Score = 36.6 bits (83), Expect = 0.17
Identities = 27/121 (22%), Positives = 52/121 (42%), Gaps = 12/121 (9%)
Query: 531 GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTE-----GEDLKLSCTVNKFLYR 585
G Y C+ NK G++ + + + + + +P G D++ C V
Sbjct: 224 GNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQP 283
Query: 586 DVTWILLRTVN------NRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRAR 639
+ W+ VN + T + ++ K A T + + + L++ NV+ +D+G Y C A
Sbjct: 284 HIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEV-LSLHNVTFEDAGEYTCLAG 342
Query: 640 N 640
N
Sbjct: 343 N 343
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 310 bits (794), Expect = 6e-84
Identities = 213/563 (37%), Positives = 293/563 (52%), Gaps = 83/563 (14%)
Query: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAI-SSST 678
+L + +V D GTY C N ++ R P L L +T A+ S
Sbjct: 208 SLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDV 267
Query: 679 TLDCHANGVPEPQITWFKN---NHKIQQEPGI----------ILGPGSSTLFIERVTEED 725
L C +P I W K+ N G I L++ V+ ED
Sbjct: 268 ELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAED 327
Query: 726 EGVYHCKATNQKGSVESSAYLTV-QGTSDKSNLELITLTCT--CVAATLFWLLLTLFIRK 782
G Y C A N G SA+LTV GT +L +LT + TL + L +
Sbjct: 328 AGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPHLTCDSLTPAGRTKSPTLQFSLESG--SS 385
Query: 783 MKRSSSEIKTDYLSI---IMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFG 839
K SSS ++ LS + V LD LP D WEF R+RL LGK LG G FG
Sbjct: 386 GKSSSSLVRGVRLSSSGPALLAGLVSLD-----LPLDPL-WEFPRDRLVLGKPLGEGCFG 439
Query: 840 KVVQASAFGIK--KSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGA 897
+VV+A AFG+ + TVAVKMLK+ A+ + L++E++++ IG H N++NLLG
Sbjct: 440 QVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGV 499
Query: 898 CTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRL 957
CT++G PL VIVE GNL +L+++R P + P
Sbjct: 500 CTQEG-PLYVIVECAAKGNLREFLRARR--------------PPGPDLSP---------- 534
Query: 958 DSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRK 1017
D SSE P++ L+S ++QVARGM++L SRK
Sbjct: 535 DGPRSSEG---------------------------PLSFPVLVSCAYQVARGMQYLESRK 567
Query: 1018 CIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYS 1077
CIHRDLAARN+L++E+NV+KI DFGLAR ++ Y + + RLP+KWMAPE++FD++Y+
Sbjct: 568 CIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYT 627
Query: 1078 TKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCW 1137
+SDVWS+G+LLWEIF+LGGSPYPG+ ++E F S LREG RM P + PE+Y +M +CW
Sbjct: 628 HQSDVWSFGILLWEIFTLGGSPYPGIPVEELF-SLLREGHRMDRPPHCPPELYGLMRECW 686
Query: 1138 HRDPKERPRFAELVEKLGDLLQA 1160
H P +RP F +LVE L +L A
Sbjct: 687 HAAPSQRPTFKQLVEALDKVLLA 709
Score = 43.1 bits (100), Expect = 0.002
Identities = 42/156 (26%), Positives = 58/156 (37%), Gaps = 28/156 (17%)
Query: 621 LTIMNVSLQDSGTYACRARN---------VYTGEEILQKKEI----TIRD--------QE 659
L I + +D+G Y C AR + TG+ + + + RD Q+
Sbjct: 86 LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQ 145
Query: 660 APYLLR----NLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGPG 712
APY H V ++ C A G P P I W K+ E GI L
Sbjct: 146 APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQ 205
Query: 713 SSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTV 748
+L +E V D G Y C N GS+ + L V
Sbjct: 206 HWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDV 241
Score = 43.1 bits (100), Expect = 0.002
Identities = 33/141 (23%), Positives = 58/141 (41%), Gaps = 10/141 (7%)
Query: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKS----ARYLTRGYSL 390
T R ++ L V + + P+P + WLKDG ++ R + +SL
Sbjct: 150 THPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSL 209
Query: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
+++ V D G YT L+ N ++ +++V + + + + P +GS
Sbjct: 210 VMESVVPSDRGTYTCLV----ENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGS 265
Query: 449 RQILTCTAYGIPQPTIKWFWH 469
L C Y QP I+W H
Sbjct: 266 DVELLCKVYSDAQPHIQWLKH 286
Score = 38.5 bits (88), Expect = 0.044
Identities = 51/216 (23%), Positives = 78/216 (36%), Gaps = 61/216 (28%)
Query: 445 PLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMG-NRIE 503
P G+ C A G P PTI+W + D + G NRI
Sbjct: 163 PAGNTVKFRCPAAGNPTPTIRW------------------------LKDGQAFHGENRIG 198
Query: 504 SITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNL 563
I R + + + ++V +D G Y C+ N VG++ N Y+ DV L
Sbjct: 199 GIRLRH---QHWSLVMESVVPSDR---GTYTCLVENAVGSIRYN---YLLDV-------L 242
Query: 564 EKMP---------------TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYS----I 604
E+ P G D++L C V + W+ +N + +
Sbjct: 243 ERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYV 302
Query: 605 SKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
K A + + L + NVS +D+G Y C A N
Sbjct: 303 QVLKTADINSSEVEV-LYLRNVSAEDAGEYTCLAGN 337
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,172,633
Number of Sequences: 37866
Number of extensions: 2323564
Number of successful extensions: 14850
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 740
Number of HSP's successfully gapped in prelim test: 370
Number of HSP's that attempted gapping in prelim test: 6793
Number of HSP's gapped (non-prelim): 4930
length of query: 1338
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1224
effective length of database: 13,930,794
effective search space: 17051291856
effective search space used: 17051291856
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.