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Search of human proteins with 154813193
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154813193 IQ motif containing E isoform 2 [Homo sapiens]
(679 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154813193 IQ motif containing E isoform 2 [Homo sapiens] 1349 0.0
gi|154813191 IQ motif containing E isoform 1 [Homo sapiens] 1339 0.0
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 75 3e-13
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 72 1e-12
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 72 2e-12
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 72 2e-12
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 69 2e-11
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 69 2e-11
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 69 2e-11
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 67 4e-11
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 67 7e-11
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 67 7e-11
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 65 2e-10
gi|50083293 coiled-coil domain containing 123 [Homo sapiens] 63 8e-10
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 62 2e-09
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 62 2e-09
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 61 3e-09
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 61 3e-09
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 61 4e-09
gi|21735548 centrosomal protein 2 [Homo sapiens] 61 4e-09
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 60 9e-09
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 60 9e-09
gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo sapi... 59 1e-08
gi|221219020 NYD-SP11 protein [Homo sapiens] 59 1e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 59 1e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 59 1e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 59 1e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 59 1e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 59 1e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 59 1e-08
>gi|154813193 IQ motif containing E isoform 2 [Homo sapiens]
Length = 679
Score = 1349 bits (3492), Expect = 0.0
Identities = 679/679 (100%), Positives = 679/679 (100%)
Query: 1 MFLGTGEPALDTKAKRKAFHKPPPTSPKSPYLSKPRKVASWRSLRTAGSMPLGGRASLTP 60
MFLGTGEPALDTKAKRKAFHKPPPTSPKSPYLSKPRKVASWRSLRTAGSMPLGGRASLTP
Sbjct: 1 MFLGTGEPALDTKAKRKAFHKPPPTSPKSPYLSKPRKVASWRSLRTAGSMPLGGRASLTP 60
Query: 61 QKLWLGTAKPGSLTQALNSPLTWEHAWTGVPGGTPDCLTDTFRVKRPHLRRSASNGHVPG 120
QKLWLGTAKPGSLTQALNSPLTWEHAWTGVPGGTPDCLTDTFRVKRPHLRRSASNGHVPG
Sbjct: 61 QKLWLGTAKPGSLTQALNSPLTWEHAWTGVPGGTPDCLTDTFRVKRPHLRRSASNGHVPG 120
Query: 121 TPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTD 180
TPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTD
Sbjct: 121 TPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTD 180
Query: 181 FVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYY 240
FVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYY
Sbjct: 181 FVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYY 240
Query: 241 EEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLD 300
EEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLD
Sbjct: 241 EEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLD 300
Query: 301 RVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSS 360
RVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSS
Sbjct: 301 RVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSS 360
Query: 361 ALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR 420
ALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR
Sbjct: 361 ALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR 420
Query: 421 EGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQ 480
EGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQ
Sbjct: 421 EGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQ 480
Query: 481 DWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKVYKHKKKKAVLDEAAVVLQAAFRGH 540
DWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKVYKHKKKKAVLDEAAVVLQAAFRGH
Sbjct: 481 DWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKVYKHKKKKAVLDEAAVVLQAAFRGH 540
Query: 541 LTRTKLLASKAHGSEPPSVPGLPDQSSPVPRVPSPIAQATGSPVQEEAIVIIQSALRAHL 600
LTRTKLLASKAHGSEPPSVPGLPDQSSPVPRVPSPIAQATGSPVQEEAIVIIQSALRAHL
Sbjct: 541 LTRTKLLASKAHGSEPPSVPGLPDQSSPVPRVPSPIAQATGSPVQEEAIVIIQSALRAHL 600
Query: 601 ARARHSATGKRTTTAASTRRRSASATHGDASSPPFLAALPDPSPSGPQALAPLPGDDVNS 660
ARARHSATGKRTTTAASTRRRSASATHGDASSPPFLAALPDPSPSGPQALAPLPGDDVNS
Sbjct: 601 ARARHSATGKRTTTAASTRRRSASATHGDASSPPFLAALPDPSPSGPQALAPLPGDDVNS 660
Query: 661 DDSDDIVIAPSLPTKNFPV 679
DDSDDIVIAPSLPTKNFPV
Sbjct: 661 DDSDDIVIAPSLPTKNFPV 679
>gi|154813191 IQ motif containing E isoform 1 [Homo sapiens]
Length = 695
Score = 1339 bits (3465), Expect = 0.0
Identities = 679/695 (97%), Positives = 679/695 (97%), Gaps = 16/695 (2%)
Query: 1 MFLGTGEPALDT----------------KAKRKAFHKPPPTSPKSPYLSKPRKVASWRSL 44
MFLGTGEPALDT KAKRKAFHKPPPTSPKSPYLSKPRKVASWRSL
Sbjct: 1 MFLGTGEPALDTGDDSLSAVTFDSDVETKAKRKAFHKPPPTSPKSPYLSKPRKVASWRSL 60
Query: 45 RTAGSMPLGGRASLTPQKLWLGTAKPGSLTQALNSPLTWEHAWTGVPGGTPDCLTDTFRV 104
RTAGSMPLGGRASLTPQKLWLGTAKPGSLTQALNSPLTWEHAWTGVPGGTPDCLTDTFRV
Sbjct: 61 RTAGSMPLGGRASLTPQKLWLGTAKPGSLTQALNSPLTWEHAWTGVPGGTPDCLTDTFRV 120
Query: 105 KRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSR 164
KRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSR
Sbjct: 121 KRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSR 180
Query: 165 KDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDM 224
KDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDM
Sbjct: 181 KDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDM 240
Query: 225 KTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRS 284
KTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRS
Sbjct: 241 KTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRS 300
Query: 285 VQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHA 344
VQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHA
Sbjct: 301 VQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHA 360
Query: 345 AEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQ 404
AEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQ
Sbjct: 361 AEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQ 420
Query: 405 LLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHK 464
LLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHK
Sbjct: 421 LLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHK 480
Query: 465 AQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKVYKHKKKKA 524
AQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKVYKHKKKKA
Sbjct: 481 AQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKVYKHKKKKA 540
Query: 525 VLDEAAVVLQAAFRGHLTRTKLLASKAHGSEPPSVPGLPDQSSPVPRVPSPIAQATGSPV 584
VLDEAAVVLQAAFRGHLTRTKLLASKAHGSEPPSVPGLPDQSSPVPRVPSPIAQATGSPV
Sbjct: 541 VLDEAAVVLQAAFRGHLTRTKLLASKAHGSEPPSVPGLPDQSSPVPRVPSPIAQATGSPV 600
Query: 585 QEEAIVIIQSALRAHLARARHSATGKRTTTAASTRRRSASATHGDASSPPFLAALPDPSP 644
QEEAIVIIQSALRAHLARARHSATGKRTTTAASTRRRSASATHGDASSPPFLAALPDPSP
Sbjct: 601 QEEAIVIIQSALRAHLARARHSATGKRTTTAASTRRRSASATHGDASSPPFLAALPDPSP 660
Query: 645 SGPQALAPLPGDDVNSDDSDDIVIAPSLPTKNFPV 679
SGPQALAPLPGDDVNSDDSDDIVIAPSLPTKNFPV
Sbjct: 661 SGPQALAPLPGDDVNSDDSDDIVIAPSLPTKNFPV 695
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 74.7 bits (182), Expect = 3e-13
Identities = 87/430 (20%), Positives = 194/430 (45%), Gaps = 40/430 (9%)
Query: 136 ELKKSLHVQKSDVDLMRTKLRRLEEENSRK--DRQI----EQLLDPSRGTD----FVRTL 185
+L S +++ + + + ++ EEE +RK ++Q+ QL D + D + +L
Sbjct: 1331 KLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESL 1390
Query: 186 AEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMK--TTNLEEMRIAMETYYEEV 243
E + L QR+ + + + T ++LQ ++ T +L+ R ++
Sbjct: 1391 EEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQ 1450
Query: 244 HRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTE-------ENQSLK 296
+ LLA ++ + E+ ++ + LSL+R+++E E +N+ L+
Sbjct: 1451 KKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLR 1510
Query: 297 EDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACL 356
D++ ++S+ + K +E SK L +++ E+ +L +E + A E + +
Sbjct: 1511 ADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELE-DELQATEDAKLRLEVNM 1569
Query: 357 ASSSALHR---QPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEV---KQLLQAKA 410
+ A Q R ++N++ +RL ++ ++E L+++ QR L V K++
Sbjct: 1570 QAMKAQFERDLQTRDEQNEEKKRL--LIKQVRELEAELEDERKQRALAVASKKKMEIDLK 1627
Query: 411 DLEKELECAREGEEERREREEVLREEIQTLTSKLQEL-----------QEMKKEEKEDCP 459
DLE ++E A + +E ++ L+ +++ +L+E +E +K+ K
Sbjct: 1628 DLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEA 1687
Query: 460 EVPHKAQELPAPTPSSRHCEQDWPPDSSE-EGLPRPRSPCSDGRRDAAARVLQAQWKVYK 518
E+ +EL + + RH EQ+ + E +S D +R AR+ Q + ++ +
Sbjct: 1688 EILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEE 1747
Query: 519 HKKKKAVLDE 528
+ +L++
Sbjct: 1748 EQSNMELLND 1757
Score = 53.1 bits (126), Expect = 8e-07
Identities = 73/374 (19%), Positives = 161/374 (43%), Gaps = 44/374 (11%)
Query: 127 KEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEE-NSRKDRQIE-----QLLDPSRGTD 180
K+D+ + EL+KS + V+ MRT+L LE+E + +D ++ Q + D
Sbjct: 1520 KDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERD 1579
Query: 181 FVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTIS---KLQTDMK--TTNLEEMRIA 235
+ +I +++ +LE + K++ ++ K++ D+K +E A
Sbjct: 1580 LQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA 1639
Query: 236 METYYEEVHRLQTL-------LASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQEL 288
+ +++ +LQ L + + + + K K+ K + + +L L +
Sbjct: 1640 RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASS 1699
Query: 289 TEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPV 348
+ +++ D + + + + K RL RI +LE++L +S+ +
Sbjct: 1700 ERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRF 1759
Query: 349 RS------------HPPACLASSSALHRQPRGDRNKD----HERLRGAVRD-LKEERTAL 391
R A S RQ +NK+ + L GAV+ K +AL
Sbjct: 1760 RKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISAL 1819
Query: 392 QEQLLQRDLEVKQLLQAKA-------DLEKEL-ECAREGEEERREREEVLREEIQTLTSK 443
+ ++ Q + +++Q + +A EK+L E + E+ERR ++ +E+++ ++
Sbjct: 1820 EAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQ-YKEQMEKANAR 1878
Query: 444 LQELQEMKKEEKED 457
+++L+ +E +E+
Sbjct: 1879 MKQLKRQLEEAEEE 1892
Score = 51.6 bits (122), Expect = 2e-06
Identities = 92/470 (19%), Positives = 190/470 (40%), Gaps = 80/470 (17%)
Query: 119 PGTPVYREKEDMY---DEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDP 175
P V R++E++ +E++++K+ + +++ M K ++L EE + Q++ +
Sbjct: 843 PLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETEL 902
Query: 176 SRGTDFVRT-LAEKRPDASWVINGLKQRILK---------------------LEQQCKEK 213
+ +R LA K+ + +++ L+ R+ + LE+Q E+
Sbjct: 903 FAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE 962
Query: 214 DGTISKLQ-----TDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGA 268
+G KLQ + K +EE + +E + + + L+ L E++ A
Sbjct: 963 EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA 1022
Query: 269 KRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIV 328
K K+ R+ QE+ + L+E L + T + K + ++ L +I
Sbjct: 1023 KNLAKI--------RNKQEVMISD--LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA 1072
Query: 329 ELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHER-LRGAVRDLKEE 387
EL+ ++ ++ + E ++ LA RGD H+ VR+L+ +
Sbjct: 1073 ELQAQIDELKLQLAKKEEELQG----ALA---------RGDDETLHKNNALKVVRELQAQ 1119
Query: 388 RTALQEQLLQRDLEVKQLLQAKADLEKELECAR------------------EGEEERRER 429
LQE + + K DL +ELE + + E+E E
Sbjct: 1120 IAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAEL 1179
Query: 430 EEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSE- 488
++ L EE + +++Q++++ E+ E +A+ A ++ Q D+ E
Sbjct: 1180 KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK---QGLETDNKEL 1236
Query: 489 ----EGLPRPRSPCSDGRRDAAARVLQAQWKVYKHKKKKAVLDEAAVVLQ 534
+ L + ++ R+ A+V + KV + + + L E A LQ
Sbjct: 1237 ACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286
Score = 48.9 bits (115), Expect = 2e-05
Identities = 75/366 (20%), Positives = 147/366 (40%), Gaps = 42/366 (11%)
Query: 126 EKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEE-NSRKDRQIEQLLDPSRGTDFVRT 184
E D+ D+I EL+ + +D ++ +L + EEE R ++ L + VR
Sbjct: 1063 ETTDLQDQIAELQ-------AQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRE 1115
Query: 185 LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMK-----TTNLEEMRIAMETY 239
L + + K K E+Q ++ + L+T+++ T +E+R E
Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE-- 1173
Query: 240 YEEVHRLQTLLASSETTGKKPLGE-KKTGAKRQKKMGSALLSLSRSVQELTEENQSLKED 298
+EV L+ L + + + ++ A +++ L R L + Q L+ D
Sbjct: 1174 -QEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETD 1232
Query: 299 LDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLAS 358
+ + + + E + +L ++ EL K+S + + AE
Sbjct: 1233 NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNV 1292
Query: 359 SSALHR-QPRGDR-NKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKA-DLEKE 415
S+ L + +G + KD L ++D +E LLQ + K L ++ LE+E
Sbjct: 1293 STLLEEAEKKGIKFAKDAASLESQLQDTQE--------LLQEETRQKLNLSSRIRQLEEE 1344
Query: 416 LECAREGEEERREREEVLREEIQTLTSKL--------------QELQEMKKEEKEDCPEV 461
+E +EE E + L +++ L S+L + L+E KK+ +D +
Sbjct: 1345 KNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEAL 1404
Query: 462 PHKAQE 467
+ +E
Sbjct: 1405 SQRLEE 1410
Score = 31.6 bits (70), Expect = 2.5
Identities = 51/242 (21%), Positives = 88/242 (36%), Gaps = 35/242 (14%)
Query: 125 REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF--- 181
+E++++ DEI + + ++ +LEEE + +E L D R T
Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVD 1767
Query: 182 --------VRTLAEKRPDASWVI----NGLKQRILKLEQQCKEK-DGTISKLQT------ 222
R+ A+K +A + LK ++ +LE K K TIS L+
Sbjct: 1768 TLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLE 1827
Query: 223 DMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLS 282
+ +E A + +L+ + E + K+ K +M L
Sbjct: 1828 EQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLE 1887
Query: 283 RSVQELTEENQSLK-------------EDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVE 329
+ +E T N S + E L R +ST + G + +S R RR +
Sbjct: 1888 EAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLH 1947
Query: 330 LE 331
LE
Sbjct: 1948 LE 1949
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 72.4 bits (176), Expect = 1e-12
Identities = 75/354 (21%), Positives = 157/354 (44%), Gaps = 33/354 (9%)
Query: 132 DEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPD 191
+E+ +L++ ++ Q +++ ++T E +++E G + +R L K +
Sbjct: 1337 EEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDE 1396
Query: 192 ASWVINGLKQRILKLEQQCKEKDGTISKLQT------DMKTTNLEEMRIAMETYYEEVHR 245
+I+ ++ + L Q EK+ ++K+QT D+ ++ + + + E + +
Sbjct: 1397 LQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQ 1456
Query: 246 LQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLST 305
LQ L + ++ E + + Q+K+ +AL+S +E +EN+SL+E+L T
Sbjct: 1457 LQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISR----KEALKENKSLQEELSLARGT 1512
Query: 306 SPTISKTQGYVE-------WSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLAS 358
++K+ VE K +L R+ L+++ + + + +S +C +
Sbjct: 1513 IERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESL 1572
Query: 359 SSALHRQPRGDRNKDHERLRGAVRDLKE----ERTALQEQLLQRDLEVKQLLQAKADLEK 414
AL +D E+L + LK E T QE+ + E + LLQ+ ++
Sbjct: 1573 KLALE-----GLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSN 1627
Query: 415 ELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
E E + E +R+E Q L KL+ + KKE ++ E + +E+
Sbjct: 1628 E-------AERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEM 1674
Score = 52.8 bits (125), Expect = 1e-06
Identities = 78/391 (19%), Positives = 167/391 (42%), Gaps = 76/391 (19%)
Query: 125 REKED----MYDEIIELKKSLHVQKSDVDLMRTKL-RRLEEENSRKDRQIEQ-LLDPSRG 178
R KED + D++ ++ S+H+++ +++ R + +++ E ++ + Q++Q + D +G
Sbjct: 2227 RLKEDNCSVLKDQLRQM--SIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQG 2284
Query: 179 TDFVRTLAEKRPDASWVINGLKQRILKLE-----------------QQCKEKDGTI---- 217
+ + L + + + + + + KLE ++CKE+ G +
Sbjct: 2285 EN--KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGII 2342
Query: 218 ---------SKLQTDMKTTNLEEMRIAMETYYEEVH----RLQTLLASSETTGKKPLGEK 264
SK + T+L+ R +EE++ ++ +LL+ E + + E
Sbjct: 2343 RQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAEL 2402
Query: 265 KTGAKRQKKMGSALLSLSRSVQ-ELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRL 323
+ ++ K LLS L EEN+ + ++++ T TI K
Sbjct: 2403 RQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKEN---------- 2452
Query: 324 LRRIVELE---KKLSVMESSKSHAA---EPVRSHPPACLASSSALHRQPRGDRNKDHERL 377
+++ +L+ K +S +++ + + + + + L ++ + NK E +
Sbjct: 2453 IQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEI 2512
Query: 378 RGA---VRDLKEERTALQEQLLQ-----------RDLEVKQLLQAKADLEKELECAREGE 423
RG + DL E L +L+Q +D + KQLL+ + KELE
Sbjct: 2513 RGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKL 2572
Query: 424 EERREREEVLREEIQTLTSKLQ-ELQEMKKE 453
EE+ + E E+++ + LQ E Q++ KE
Sbjct: 2573 EEKLKESEEANEDLRRSFNALQEEKQDLSKE 2603
Score = 50.1 bits (118), Expect = 7e-06
Identities = 89/390 (22%), Positives = 162/390 (41%), Gaps = 69/390 (17%)
Query: 110 RRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQI 169
+++A N T + E++ + ++ EL S V +R ++++LE + +RQ
Sbjct: 729 KKNADNNSSAFTALSEERDQLLSQVKEL--------SMVTELRAQVKQLEMNLAEAERQ- 779
Query: 170 EQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNL 229
R D+ A N L ++I L + K KD I LQ + L
Sbjct: 780 -------RRLDYESQTAHD--------NLLTEQIHSLSIEAKSKDVKIEVLQNE-----L 819
Query: 230 EEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQ--- 286
+++++ + LQ+ L + E+ E GA+R + + S + LS+++
Sbjct: 820 DDVQLQFSEQSTLIRSLQSQLQNKES-------EVLEGAERVRHISSKVEELSQALSQKE 872
Query: 287 -ELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVEL-EKKLSVMESSK--- 341
E+T+ +Q L E V + TI + V + ++V+L E+K S+ K
Sbjct: 873 LEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLK 932
Query: 342 ------SHAAEPVRSHPPACLASSSALHR-----QPRGDRNKDHERLRGAVRDLKEERTA 390
S A E + SS L + P G +K E L+ LK+E
Sbjct: 933 EQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISK--EELQHEFDLLKKENEQ 990
Query: 391 LQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQ-----------T 439
+ +L + K+LLQ + LE+EL ++ ++ E R E++
Sbjct: 991 RKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKC 1050
Query: 440 LTSKLQELQ-EMKKEEKEDCPEVPHKAQEL 468
+TSK QE++ +K+ E E+ H ++L
Sbjct: 1051 VTSKCQEIEIYLKQTISEKEVELQHIRKDL 1080
Score = 48.9 bits (115), Expect = 2e-05
Identities = 84/411 (20%), Positives = 162/411 (39%), Gaps = 78/411 (18%)
Query: 128 EDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSR----KDRQIEQLLDPSRGTDFVR 183
E + + +++ + Q + D + +L L+EE + DR + + S + ++
Sbjct: 1514 ERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLK 1573
Query: 184 T----LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISK-----LQTDMKTTN-LEEMR 233
L E + I LK + + +EK + K LQ+ +N E ++
Sbjct: 1574 LALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQ 1633
Query: 234 IAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQ----ELT 289
+E +E L L S+E K+ + + + ++M + ++S Q EL
Sbjct: 1634 HVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELE 1693
Query: 290 EENQ-------------------------SLKEDLDRVLSTSPTISKTQGYVEWSKPRLL 324
EEN S+KE+L+RV T+SK + K L
Sbjct: 1694 EENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLS 1753
Query: 325 RRIVELE-------KKLSVMESSKSH------AAEPVRSHP--------------PACLA 357
+ +L+ K + +E+++ H E +S P P C
Sbjct: 1754 EEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSE 1813
Query: 358 S-SSALHRQPRGDRN-KDHERLRGAVRDLKE--ERTALQEQLLQRDLEVKQLLQAKADLE 413
S SA P ++ H+ + ++ + + ER A E+ Q++ E Q L+ + +
Sbjct: 1814 SVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTL 1873
Query: 414 KELECAREGE----EERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPE 460
++GE +E + +L ++IQ S++ +L+E +EEK+D E
Sbjct: 1874 LSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEE 1924
Score = 48.9 bits (115), Expect = 2e-05
Identities = 82/391 (20%), Positives = 156/391 (39%), Gaps = 53/391 (13%)
Query: 98 LTDTFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRR 157
L + R R H+ S + + +ED+ +++I +K S Q +V L + K
Sbjct: 2508 LKEEIRGLRSHMDDLNSENAKLDAELIQYREDL-NQVITIKDSQQKQLLEVQLQQNK--E 2564
Query: 158 LEEENSRKDRQIEQLLDPSRGTDFVRT---LAEKRPDASWVINGLKQRILKLEQQCK--E 212
LE + ++ + ++++ + + D R+ L E++ D S I LK I +L +Q +
Sbjct: 2565 LENKYAKLEEKLKESEEANE--DLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQ 2622
Query: 213 KDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGE----KKTGA 268
++GT+ +K EEVHRL L +SS+ + E +K A
Sbjct: 2623 EEGTLGLYHAQLKVKE------------EEVHRLSALFSSSQKRIAELEEELVCVQKEAA 2670
Query: 269 KR----QKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLL 324
K+ + K+ L L + E ++ +E + + + + V L
Sbjct: 2671 KKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLT 2730
Query: 325 RRIVELEKKLSVMESSKSHAAEPV---RSHPPACLASSSALHRQPRGDRNKDH------- 374
+I + +S +++S+ HA E + + A L + L Q +R +D
Sbjct: 2731 AQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAF 2790
Query: 375 -------------ERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
E+L + E+ L QL +V+ +A A L+ E +
Sbjct: 2791 SMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWN 2850
Query: 422 GEEERREREEVLREEIQTLTSKLQELQEMKK 452
E+ R+ EE + ++ E+Q +KK
Sbjct: 2851 ELEKFRKSEEGKQRSAAQPSTSPAEVQSLKK 2881
Score = 40.8 bits (94), Expect = 0.004
Identities = 73/348 (20%), Positives = 148/348 (42%), Gaps = 51/348 (14%)
Query: 151 MRTKLRRLEEENSRKDRQI----EQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKL 206
M K+ +L EE +I EQL SR + + E+ + S +GLKQ ++
Sbjct: 910 MTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVS---SGLKQNYDEM 966
Query: 207 E---QQCKEK---DGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKK- 259
Q KE+ + + K + + + L+ I + + V RL+ LA+ + KK
Sbjct: 967 SPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKE 1026
Query: 260 -PLGEKKTGAKRQKKMGSAL-------------LSLSRSVQELTEENQSLKEDLDRVLST 305
PL E + G + K + L +++ E E Q +++DL+ L+
Sbjct: 1027 IPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAA 1086
Query: 306 SPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQ 365
+ Q V+ L + +++ + + +++ + + S+ A S AL ++
Sbjct: 1087 E---EQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE 1143
Query: 366 -----PRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR 420
P + +H + +L+E+ AL+++ K+ LQ K L++ L +
Sbjct: 1144 TVVISPPCTGSSEHWK-----PELEEKILALEKE--------KEQLQKK--LQEALTSRK 1188
Query: 421 EGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
++ +E+E LREE++ LQE E+ ++ + + ++L
Sbjct: 1189 AILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQL 1236
Score = 40.8 bits (94), Expect = 0.004
Identities = 69/342 (20%), Positives = 147/342 (42%), Gaps = 38/342 (11%)
Query: 136 ELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEK-----RP 190
EL++ L ++ +V ++ R +E+ S +R ++ L +FV+T ++K +
Sbjct: 2009 ELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKAL-------EFVQTESQKDLEITKE 2061
Query: 191 DASWVINGLKQRILKLEQQCKEKDGTIS----------KLQTDMKTTNLEEMRIAMETYY 240
+ + + K+ +L D T S KL+ ++++ N E ++ M+
Sbjct: 2062 NLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQS-NKESVKSQMKQKD 2120
Query: 241 EEVHRLQTLLASSETTGKKPLGEKKTGAKRQK-KMGSALLSLSRSVQELTEENQSLKEDL 299
E++ R KK + EK +R+K + + + ++ + +E Q L+E+L
Sbjct: 2121 EDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENL 2180
Query: 300 DRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASS 359
D ++ +K+ ++ + R++ + E+K S SK E +R C
Sbjct: 2181 DSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKE---EEIRLKEDNC---- 2233
Query: 360 SALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQ-----LLQAKADLEK 414
S L Q R + E L+ + L+ ++ + E Q +++++Q L +L
Sbjct: 2234 SVLKDQLR-QMSIHMEELKINISRLEHDK-QIWESKAQTEVQLQQKVCDTLQGENKELLS 2291
Query: 415 ELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKE 456
+LE R + L E+++L +L +L ++ KE
Sbjct: 2292 QLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKE 2333
Score = 37.0 bits (84), Expect = 0.060
Identities = 54/284 (19%), Positives = 119/284 (41%), Gaps = 37/284 (13%)
Query: 167 RQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKT 226
+QI+QL + G + + +K + S + K +L Q KDG + LQ ++
Sbjct: 1840 QQIDQLKERIAGLEEEK---QKNKEFSQTLENEKNTLLS---QISTKDGELKMLQEEVTK 1893
Query: 227 TNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQ 286
NL +I EE+ R+ L ++E E+K ++++ + L L+ S+
Sbjct: 1894 MNLLNQQIQ-----EELSRVTKLKETAE--------EEKDDL--EERLMNQLAELNGSIG 1938
Query: 287 ELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKL--SVMESSKSHA 344
++ + + + S + K +E K +L++ ++E ++ +E +
Sbjct: 1939 NYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQ 1998
Query: 345 AEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQ 404
EP + H + + K+ ++ V+ L+++ QE++ + VK
Sbjct: 1999 KEP-----------GNKSHAKELQELLKEKQQ---EVKQLQKDCIRYQEKISALERTVKA 2044
Query: 405 LLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQ 448
L + + +K+LE +E + E + + E+ + L + Q
Sbjct: 2045 LEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQ 2088
Score = 34.7 bits (78), Expect = 0.30
Identities = 72/374 (19%), Positives = 138/374 (36%), Gaps = 77/374 (20%)
Query: 103 RVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEEN 162
+ K L + G V + +++ + KS ++ +++ ++ KL+ EE
Sbjct: 101 KAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELI 160
Query: 163 SRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQT 222
S Q+ Q AE+ +S + + + ++QQ +EK+ IS LQ
Sbjct: 161 STLQAQLTQ------------AQAEQPAQSSTEM----EEFVMMKQQLQEKEEFISTLQA 204
Query: 223 DMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLS 282
+ T E+ A + E+ R +T + E L + T A + +M L L
Sbjct: 205 QLSQTQAEQ--AAQQVVREKDARFETQVRLHE----DELLQLVTQADVETEMQQKLRVLQ 258
Query: 283 RSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKS 342
R ++E E + +D +L T ++ + + L ++L ME+
Sbjct: 259 RKLEEHEESLVGRAQVVD-LLQQELTAAEQRNQI-------------LSQQLQQMEA--- 301
Query: 343 HAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE----QLLQR 398
+H LR V +EE L E ++ +R
Sbjct: 302 ------------------------------EHNTLRNTVETEREESKILLEKMELEVAER 331
Query: 399 DLEVKQLLQAKADLEKELECAREGEEERREREEVLRE----EIQTLTSKLQELQEMKKEE 454
L L + L ++ E A + + E R L + E++ TS + LQ+ +E
Sbjct: 332 KLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQEL 391
Query: 455 KEDCPEVPHKAQEL 468
+ C + + +L
Sbjct: 392 QSACDALKDQNSKL 405
Score = 34.7 bits (78), Expect = 0.30
Identities = 72/381 (18%), Positives = 145/381 (38%), Gaps = 79/381 (20%)
Query: 127 KEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLA 186
KE++ E LKK +K + + L + SR + ++ L D S+
Sbjct: 974 KEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESK--------- 1024
Query: 187 EKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRL 246
++ P + + E+ E+D + T+ +E+ I +
Sbjct: 1025 KEIP------------LSETERGEVEEDKENKEYSEKCVTSKCQEIEIYL---------- 1062
Query: 247 QTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEE-NQSLKEDLDRVLST 305
K+ + EK+ + +K L+ Q L ++ NQ+L++ +++
Sbjct: 1063 -----------KQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLL 1111
Query: 306 SPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQ 365
IS+ Q ++ +L+ + SV + E V PP C SS H +
Sbjct: 1112 QAEISENQAIIQ----KLITSNTDASDGDSV-----ALVKETVVISPP-CTGSSE--HWK 1159
Query: 366 PRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEE 425
P + E++ ++ ++ + LQE L R +K+ + + L +EL+ ++
Sbjct: 1160 PELE-----EKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNR 1214
Query: 426 RREREEVLREEIQTLTSKLQELQEMKKE----------EKEDCPEVPHKAQEL------- 468
+E+ + +E + + +L++LQ +E ++E C P + L
Sbjct: 1215 LQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQH 1274
Query: 469 -PAPTPSSRHCEQDWPPDSSE 488
P S C DWP S +
Sbjct: 1275 HTQPVLESNLC-PDWPSHSED 1294
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 71.6 bits (174), Expect = 2e-12
Identities = 77/352 (21%), Positives = 148/352 (42%), Gaps = 34/352 (9%)
Query: 153 TKLRRLEEENSRKDRQIEQLLDPSRGTD-FVRTL-------AEKRPDASWVINGLKQ--- 201
TKLR+LEEE + Q+++ ++ + + + TL +K D + + L++
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402
Query: 202 ----RILKLEQQCKEKDGTISKLQT---------DMKTTNLEEMRIAMETYYEEVHRLQT 248
I L QQ +EK KL+ D +L+ R + ++ +
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Query: 249 LLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEE-------NQSLKEDLDR 301
LLA + K E+ ++ + LSL+R+++E E N+ LK +++
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522
Query: 302 VLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
++S+ + K +E SK L ++ E++ +L +E + A
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582
Query: 362 LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEV---KQLLQAKADLEKELEC 418
R + ++ E+ R R L E T L+++ QR L K+L DLE + +
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642
Query: 419 AREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPA 470
A +G EE ++ L+ +++ +L++ + + E E KA+ L A
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1694
Score = 52.0 bits (123), Expect = 2e-06
Identities = 78/359 (21%), Positives = 145/359 (40%), Gaps = 38/359 (10%)
Query: 121 TPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRG-- 178
T Y EK YD++ + K L + D+ + R+L +K R+ +QLL +
Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471
Query: 179 ------TDFVRTLA-EKRPDASWVINGLKQRILKLEQ--------QCKEKDGTISKLQTD 223
D A EK A + L++ + E+ + + +D SK
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531
Query: 224 MKTTNLEEMRIAMETYYEEVH-RLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLS 282
LE+ + A+ET EE+ +L+ L + T L + + M +
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL-------RLEVNMQALKGQFE 1584
Query: 283 RSVQELTEENQSLKEDLDRVLSTSPT----ISKTQGYVEWSKPRLLRRIVELEKKLSVME 338
R +Q E+N+ + L R L T K + +K +L + +LE +
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 339 SSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQL--L 396
+ A + +R L + ++ D + + ++ +++ +L+ L L
Sbjct: 1645 KGREEAIKQLRK-----LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1699
Query: 397 QRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEK 455
Q DL + + +ADLEKE E A E R L++E + L +++ +L+E +EE+
Sbjct: 1700 QEDLAAAERARKQADLEKE-ELAEELASSLSGR-NALQDEKRRLEARIAQLEEELEEEQ 1756
Score = 51.2 bits (121), Expect = 3e-06
Identities = 74/337 (21%), Positives = 135/337 (40%), Gaps = 23/337 (6%)
Query: 138 KKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVIN 197
KK L D++L + EE ++ R+++ + DF R L + R +
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK-----DFQRELEDARASRDEIFA 1680
Query: 198 GLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTG 257
K+ E++ K + + +LQ D+ + +E L LASS +
Sbjct: 1681 TAKEN----EKKAKSLEADLMQLQEDLAAAERARKQADLEK-----EELAEELASSLSGR 1731
Query: 258 KKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVE 317
EK+ R ++ L +++ +++ + + +++ + T T E
Sbjct: 1732 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1791
Query: 318 WSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERL 377
++ +L R+ EL KL ME + V+S + +A+ A Q ++
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGA-------VKSKFKSTIAALEAKIAQLEEQVEQEAREK 1844
Query: 378 RGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEI 437
+ A + LK++ L+E LLQ + E K Q K EK ++ + + E EE + I
Sbjct: 1845 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE-SQRI 1903
Query: 438 QTLTSKLQ-ELQEMKKEEKEDCPEVPHKAQELPAPTP 473
KLQ EL E + + EV +L P P
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1940
Score = 50.8 bits (120), Expect = 4e-06
Identities = 70/355 (19%), Positives = 153/355 (43%), Gaps = 54/355 (15%)
Query: 129 DMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEK 188
D+ +I ELK L ++ + ++ L RL++E ++K+ +++ +R L
Sbjct: 1080 DLQAQIAELKMQLAKKEEE---LQAALARLDDEIAQKNNALKK----------IRELEGH 1126
Query: 189 RPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMK-----TTNLEEMRIAMETYYEEV 243
D ++ + K E+Q ++ + L+T+++ T +E+R E +EV
Sbjct: 1127 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE---QEV 1183
Query: 244 HRLQTLLASSETTGKKPLGE-KKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRV 302
L+ L + + + E ++ A+ +++ L R+ L + Q+L+++ +
Sbjct: 1184 TVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1243
Query: 303 LSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVR------------- 349
+ + + VE K +L ++ EL+ K S E +++ + V
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1303
Query: 350 ----------SHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRD 399
+ A L+S ++ + + + +R L+EER +LQ+Q L +
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-LDEE 1362
Query: 400 LEVKQLLQAK--------ADLEKELECAREGEEERREREEVLREEIQTLTSKLQE 446
+E KQ L+ +D +K+L+ E E ++ ++EI+ LT + +E
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1417
Score = 49.3 bits (116), Expect = 1e-05
Identities = 85/413 (20%), Positives = 171/413 (41%), Gaps = 73/413 (17%)
Query: 120 GTPVYREKEDMYDEIIELKKSLHVQKSDVDLMR-------TKLRRLEEENSRKDRQIEQL 172
G + E++ M ++++L++ L +++ ++ K+++LE+E D Q +L
Sbjct: 945 GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 1004
Query: 173 -----LDPSRGTDFVRTLAEKRPDAS----------WVINGLKQRILKLEQQCKEKDGTI 217
L R +D LAE+ A +I+ L+ R+ K E+ +E +
Sbjct: 1005 SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK 1064
Query: 218 SKLQTDMKT---------TNLEEMRIAMETYYEEVH----RLQTLLASSETTGKKPLGEK 264
KL+ D + E+++ + EE+ RL +A KK +
Sbjct: 1065 RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1124
Query: 265 KTGAKRQKKMGS---ALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKP 321
+ Q+ + S A + ++L EE ++LK +L+ L ++ T + + E
Sbjct: 1125 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE---- 1180
Query: 322 RLLRRIVELEKKLSVMESSKSHAA---EPVRSHPPACLASSSALHRQPRGDRNKDHER-- 376
+ + L+K L E ++SH A E + H A + L + R N D +
Sbjct: 1181 ---QEVTVLKKALD--EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1235
Query: 377 -------LRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKAD--------------LEKE 415
L G +R L + + ++ + + + +V++L +D L+ E
Sbjct: 1236 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1295
Query: 416 LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
+E E + L +++ +L+S+LQ+ QE+ +EE V K ++L
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1348
Score = 47.8 bits (112), Expect = 3e-05
Identities = 61/274 (22%), Positives = 112/274 (40%), Gaps = 30/274 (10%)
Query: 197 NGLKQRILKLEQQCKEKDGTISKLQTDMKT-TNLEEMRIAMETYYEEV----HRLQTLLA 251
N LK+ K Q +EK+ +LQ + + EEMR+ + +E+ H ++ L
Sbjct: 880 NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 939
Query: 252 SSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISK 311
E G++ E+K KM +L L ++E EE K L++V + + I K
Sbjct: 940 EEEDRGQQLQAERK-------KMAQQMLDLEEQLEE--EEAARQKLQLEKVTAEAK-IKK 989
Query: 312 TQGYV--------EWSKPRLL--RRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
+ + + SK R L RI +L L+ E + + H
Sbjct: 990 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1049
Query: 362 LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
L ++ K + L R L+ + + EQ+ ++ +L A E+EL+ A
Sbjct: 1050 LKKE-----EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1104
Query: 422 GEEERREREEVLREEIQTLTSKLQELQEMKKEEK 455
++ ++ ++I+ L + +LQE E+
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138
Score = 47.0 bits (110), Expect = 6e-05
Identities = 85/388 (21%), Positives = 159/388 (40%), Gaps = 32/388 (8%)
Query: 121 TPVYREKEDMYDEI-IELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGT 179
T + + E M E+ + LKK +KS +L + K R+LE + S QI L ++
Sbjct: 1033 TKLKNKHESMISELEVRLKKE---EKSRQELEKLK-RKLEGDASDFHEQIADL--QAQIA 1086
Query: 180 DFVRTLAEKRPDASWVINGLKQRILKLEQQCK---EKDGTISKLQTDMKTTNLEEMRIAM 236
+ LA+K + + L I + K E +G IS LQ D+ + +
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146
Query: 237 ET--YYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKK---MGSALLSLSRS----VQE 287
+ EE+ L+T L E T +++ AKR+++ + AL +RS VQE
Sbjct: 1147 QKRDLGEELEALKTEL---EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Query: 288 LTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEP 347
+ +++ E+L L + + ++ +K L + +L +L V+ +K
Sbjct: 1204 MRQKHAQAVEELTEQLEQ---FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1257
Query: 348 VRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQ 407
H L + + D + L V L+ E ++ L + + + +L +
Sbjct: 1258 --EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315
Query: 408 AKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
A L +L+ +E +E ++ + +++ L + LQ+ EE E +
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375
Query: 468 LPAPTPSSRHCEQDWPP--DSSEEGLPR 493
L S+ QD+ ++ EEG R
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKR 1403
Score = 40.8 bits (94), Expect = 0.004
Identities = 49/187 (26%), Positives = 79/187 (42%), Gaps = 32/187 (17%)
Query: 269 KRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWS--KPRLLRR 326
+RQ+K + L L + +LTEE L+E L ++T+ Y E + RL +
Sbjct: 873 ERQQKAENELKELEQKHSQLTEEKNLLQEQLQ---------AETELYAEAEEMRVRLAAK 923
Query: 327 IVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKE 386
ELE+ L ME A L +Q + +R K +++ L+E
Sbjct: 924 KQELEEILHEME---------------ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 387 ERTALQEQLLQRDLEVKQLLQAK-ADLEKELECAREGEEERREREEVLREEIQTLTSKLQ 445
E A Q+ L+ K +AK LE E+ + + + ++L E I LT+ L
Sbjct: 969 EEAARQKLQLE-----KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023
Query: 446 ELQEMKK 452
E +E K
Sbjct: 1024 EEEEKAK 1030
Score = 32.0 bits (71), Expect = 1.9
Identities = 38/178 (21%), Positives = 73/178 (41%), Gaps = 20/178 (11%)
Query: 370 RNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERRER 429
RN RL V+ L + T +E++ ++ E+++ + + E EL+ + + E
Sbjct: 837 RNWQWWRLFTKVKPLLQV-TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE 895
Query: 430 EEVLREEIQT--------------LTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSS 475
+ +L+E++Q L +K QEL+E+ E + E + Q+L A
Sbjct: 896 KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 955
Query: 476 RHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKVY-----KHKKKKAVLDE 528
D EE R + +A + L+ + V K K++ +L+E
Sbjct: 956 AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013
Score = 30.4 bits (67), Expect = 5.6
Identities = 40/222 (18%), Positives = 91/222 (40%), Gaps = 16/222 (7%)
Query: 126 EKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR-GTDFVRT 184
EKE++ +E+ + + + + ++ +LEEE + +E + D R T
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 185 LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEE-V 243
L+ + + +LE+Q KE + L EM A+++ ++ +
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKE------------LRSKLHEMEGAVKSKFKSTI 1823
Query: 244 HRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVL 303
L+ +A E ++ EK+ K K+ L + V++ + + KE ++
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1883
Query: 304 STSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAA 345
+ + + E R+ +L+++L E+++S+ A
Sbjct: 1884 ARVKQLKRQLEEAEEESQRINANRRKLQRELD--EATESNEA 1923
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 71.6 bits (174), Expect = 2e-12
Identities = 77/352 (21%), Positives = 148/352 (42%), Gaps = 34/352 (9%)
Query: 153 TKLRRLEEENSRKDRQIEQLLDPSRGTD-FVRTL-------AEKRPDASWVINGLKQ--- 201
TKLR+LEEE + Q+++ ++ + + + TL +K D + + L++
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395
Query: 202 ----RILKLEQQCKEKDGTISKLQT---------DMKTTNLEEMRIAMETYYEEVHRLQT 248
I L QQ +EK KL+ D +L+ R + ++ +
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Query: 249 LLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEE-------NQSLKEDLDR 301
LLA + K E+ ++ + LSL+R+++E E N+ LK +++
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515
Query: 302 VLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
++S+ + K +E SK L ++ E++ +L +E + A
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575
Query: 362 LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEV---KQLLQAKADLEKELEC 418
R + ++ E+ R R L E T L+++ QR L K+L DLE + +
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635
Query: 419 AREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPA 470
A +G EE ++ L+ +++ +L++ + + E E KA+ L A
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1687
Score = 52.0 bits (123), Expect = 2e-06
Identities = 78/359 (21%), Positives = 145/359 (40%), Gaps = 38/359 (10%)
Query: 121 TPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRG-- 178
T Y EK YD++ + K L + D+ + R+L +K R+ +QLL +
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464
Query: 179 ------TDFVRTLA-EKRPDASWVINGLKQRILKLEQ--------QCKEKDGTISKLQTD 223
D A EK A + L++ + E+ + + +D SK
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524
Query: 224 MKTTNLEEMRIAMETYYEEVH-RLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLS 282
LE+ + A+ET EE+ +L+ L + T L + + M +
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL-------RLEVNMQALKGQFE 1577
Query: 283 RSVQELTEENQSLKEDLDRVLSTSPT----ISKTQGYVEWSKPRLLRRIVELEKKLSVME 338
R +Q E+N+ + L R L T K + +K +L + +LE +
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 339 SSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQL--L 396
+ A + +R L + ++ D + + ++ +++ +L+ L L
Sbjct: 1638 KGREEAIKQLRK-----LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1692
Query: 397 QRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEK 455
Q DL + + +ADLEKE E A E R L++E + L +++ +L+E +EE+
Sbjct: 1693 QEDLAAAERARKQADLEKE-ELAEELASSLSGR-NALQDEKRRLEARIAQLEEELEEEQ 1749
Score = 51.2 bits (121), Expect = 3e-06
Identities = 74/337 (21%), Positives = 135/337 (40%), Gaps = 23/337 (6%)
Query: 138 KKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVIN 197
KK L D++L + EE ++ R+++ + DF R L + R +
Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK-----DFQRELEDARASRDEIFA 1673
Query: 198 GLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTG 257
K+ E++ K + + +LQ D+ + +E L LASS +
Sbjct: 1674 TAKEN----EKKAKSLEADLMQLQEDLAAAERARKQADLEK-----EELAEELASSLSGR 1724
Query: 258 KKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVE 317
EK+ R ++ L +++ +++ + + +++ + T T E
Sbjct: 1725 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1784
Query: 318 WSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERL 377
++ +L R+ EL KL ME + V+S + +A+ A Q ++
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGA-------VKSKFKSTIAALEAKIAQLEEQVEQEAREK 1837
Query: 378 RGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEI 437
+ A + LK++ L+E LLQ + E K Q K EK ++ + + E EE + I
Sbjct: 1838 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE-SQRI 1896
Query: 438 QTLTSKLQ-ELQEMKKEEKEDCPEVPHKAQELPAPTP 473
KLQ EL E + + EV +L P P
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1933
Score = 50.8 bits (120), Expect = 4e-06
Identities = 70/355 (19%), Positives = 153/355 (43%), Gaps = 54/355 (15%)
Query: 129 DMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEK 188
D+ +I ELK L ++ + ++ L RL++E ++K+ +++ +R L
Sbjct: 1073 DLQAQIAELKMQLAKKEEE---LQAALARLDDEIAQKNNALKK----------IRELEGH 1119
Query: 189 RPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMK-----TTNLEEMRIAMETYYEEV 243
D ++ + K E+Q ++ + L+T+++ T +E+R E +EV
Sbjct: 1120 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE---QEV 1176
Query: 244 HRLQTLLASSETTGKKPLGE-KKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRV 302
L+ L + + + E ++ A+ +++ L R+ L + Q+L+++ +
Sbjct: 1177 TVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1236
Query: 303 LSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVR------------- 349
+ + + VE K +L ++ EL+ K S E +++ + V
Sbjct: 1237 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1296
Query: 350 ----------SHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRD 399
+ A L+S ++ + + + +R L+EER +LQ+Q L +
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-LDEE 1355
Query: 400 LEVKQLLQAK--------ADLEKELECAREGEEERREREEVLREEIQTLTSKLQE 446
+E KQ L+ +D +K+L+ E E ++ ++EI+ LT + +E
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1410
Score = 49.3 bits (116), Expect = 1e-05
Identities = 85/413 (20%), Positives = 171/413 (41%), Gaps = 73/413 (17%)
Query: 120 GTPVYREKEDMYDEIIELKKSLHVQKSDVDLMR-------TKLRRLEEENSRKDRQIEQL 172
G + E++ M ++++L++ L +++ ++ K+++LE+E D Q +L
Sbjct: 938 GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 997
Query: 173 -----LDPSRGTDFVRTLAEKRPDAS----------WVINGLKQRILKLEQQCKEKDGTI 217
L R +D LAE+ A +I+ L+ R+ K E+ +E +
Sbjct: 998 SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK 1057
Query: 218 SKLQTDMKT---------TNLEEMRIAMETYYEEVH----RLQTLLASSETTGKKPLGEK 264
KL+ D + E+++ + EE+ RL +A KK +
Sbjct: 1058 RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1117
Query: 265 KTGAKRQKKMGS---ALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKP 321
+ Q+ + S A + ++L EE ++LK +L+ L ++ T + + E
Sbjct: 1118 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE---- 1173
Query: 322 RLLRRIVELEKKLSVMESSKSHAA---EPVRSHPPACLASSSALHRQPRGDRNKDHER-- 376
+ + L+K L E ++SH A E + H A + L + R N D +
Sbjct: 1174 ---QEVTVLKKALD--EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1228
Query: 377 -------LRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKAD--------------LEKE 415
L G +R L + + ++ + + + +V++L +D L+ E
Sbjct: 1229 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1288
Query: 416 LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
+E E + L +++ +L+S+LQ+ QE+ +EE V K ++L
Sbjct: 1289 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1341
Score = 47.8 bits (112), Expect = 3e-05
Identities = 61/274 (22%), Positives = 112/274 (40%), Gaps = 30/274 (10%)
Query: 197 NGLKQRILKLEQQCKEKDGTISKLQTDMKT-TNLEEMRIAMETYYEEV----HRLQTLLA 251
N LK+ K Q +EK+ +LQ + + EEMR+ + +E+ H ++ L
Sbjct: 873 NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 932
Query: 252 SSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISK 311
E G++ E+K KM +L L ++E EE K L++V + + I K
Sbjct: 933 EEEDRGQQLQAERK-------KMAQQMLDLEEQLEE--EEAARQKLQLEKVTAEAK-IKK 982
Query: 312 TQGYV--------EWSKPRLL--RRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
+ + + SK R L RI +L L+ E + + H
Sbjct: 983 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1042
Query: 362 LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
L ++ K + L R L+ + + EQ+ ++ +L A E+EL+ A
Sbjct: 1043 LKKE-----EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1097
Query: 422 GEEERREREEVLREEIQTLTSKLQELQEMKKEEK 455
++ ++ ++I+ L + +LQE E+
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131
Score = 47.0 bits (110), Expect = 6e-05
Identities = 85/388 (21%), Positives = 159/388 (40%), Gaps = 32/388 (8%)
Query: 121 TPVYREKEDMYDEI-IELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGT 179
T + + E M E+ + LKK +KS +L + K R+LE + S QI L ++
Sbjct: 1026 TKLKNKHESMISELEVRLKKE---EKSRQELEKLK-RKLEGDASDFHEQIADL--QAQIA 1079
Query: 180 DFVRTLAEKRPDASWVINGLKQRILKLEQQCK---EKDGTISKLQTDMKTTNLEEMRIAM 236
+ LA+K + + L I + K E +G IS LQ D+ + +
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139
Query: 237 ET--YYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKK---MGSALLSLSRS----VQE 287
+ EE+ L+T L E T +++ AKR+++ + AL +RS VQE
Sbjct: 1140 QKRDLGEELEALKTEL---EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196
Query: 288 LTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEP 347
+ +++ E+L L + + ++ +K L + +L +L V+ +K
Sbjct: 1197 MRQKHAQAVEELTEQLEQ---FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1250
Query: 348 VRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQ 407
H L + + D + L V L+ E ++ L + + + +L +
Sbjct: 1251 --EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308
Query: 408 AKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
A L +L+ +E +E ++ + +++ L + LQ+ EE E +
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368
Query: 468 LPAPTPSSRHCEQDWPP--DSSEEGLPR 493
L S+ QD+ ++ EEG R
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKR 1396
Score = 40.8 bits (94), Expect = 0.004
Identities = 49/187 (26%), Positives = 79/187 (42%), Gaps = 32/187 (17%)
Query: 269 KRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWS--KPRLLRR 326
+RQ+K + L L + +LTEE L+E L ++T+ Y E + RL +
Sbjct: 866 ERQQKAENELKELEQKHSQLTEEKNLLQEQLQ---------AETELYAEAEEMRVRLAAK 916
Query: 327 IVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKE 386
ELE+ L ME A L +Q + +R K +++ L+E
Sbjct: 917 KQELEEILHEME---------------ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 387 ERTALQEQLLQRDLEVKQLLQAK-ADLEKELECAREGEEERREREEVLREEIQTLTSKLQ 445
E A Q+ L+ K +AK LE E+ + + + ++L E I LT+ L
Sbjct: 962 EEAARQKLQLE-----KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016
Query: 446 ELQEMKK 452
E +E K
Sbjct: 1017 EEEEKAK 1023
Score = 32.0 bits (71), Expect = 1.9
Identities = 38/178 (21%), Positives = 73/178 (41%), Gaps = 20/178 (11%)
Query: 370 RNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERRER 429
RN RL V+ L + T +E++ ++ E+++ + + E EL+ + + E
Sbjct: 830 RNWQWWRLFTKVKPLLQV-TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE 888
Query: 430 EEVLREEIQT--------------LTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSS 475
+ +L+E++Q L +K QEL+E+ E + E + Q+L A
Sbjct: 889 KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 948
Query: 476 RHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKVY-----KHKKKKAVLDE 528
D EE R + +A + L+ + V K K++ +L+E
Sbjct: 949 AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006
Score = 30.4 bits (67), Expect = 5.6
Identities = 40/222 (18%), Positives = 91/222 (40%), Gaps = 16/222 (7%)
Query: 126 EKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR-GTDFVRT 184
EKE++ +E+ + + + + ++ +LEEE + +E + D R T
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 185 LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEE-V 243
L+ + + +LE+Q KE + L EM A+++ ++ +
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKE------------LRSKLHEMEGAVKSKFKSTI 1816
Query: 244 HRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVL 303
L+ +A E ++ EK+ K K+ L + V++ + + KE ++
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1876
Query: 304 STSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAA 345
+ + + E R+ +L+++L E+++S+ A
Sbjct: 1877 ARVKQLKRQLEEAEEESQRINANRRKLQRELD--EATESNEA 1916
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 68.6 bits (166), Expect = 2e-11
Identities = 83/366 (22%), Positives = 156/366 (42%), Gaps = 48/366 (13%)
Query: 157 RLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILK----LEQQCKE 212
+LEEE + ++R +L R E+ A ++R + L Q+ E
Sbjct: 1376 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAE 1435
Query: 213 KDGTISKLQT---------DMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGE 263
K T+ +L+ D T +LE+ R + T ++ + LLA + + + E
Sbjct: 1436 KTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEE 1495
Query: 264 KKTGAKRQKKMGSALLSLSRSV-------QELTEENQSLKEDLDRVLSTSPTISKTQ--- 313
++ ++ + LSL+R++ +EL +N++L+ +L+ +LS+ + K+
Sbjct: 1496 RERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHEL 1555
Query: 314 ----GYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGD 369
E + L ++ ELE +L+ E +K V+ A + R +G
Sbjct: 1556 ERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQ-------ALKTQHERDLQGR 1608
Query: 370 RNKDHERLRGAVRDLKEERTALQEQLLQRDLEV---KQLLQAKADLEKELECAREGEEE- 425
ER R + L++ E+ QR L V K+L +L+ ++ A +G+EE
Sbjct: 1609 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1668
Query: 426 -------RREREEVLREEIQTLTSK---LQELQEMKKEEKEDCPEVPHKAQELPAPTPSS 475
+ + +E+ RE +T TS+ + +E +K K EV +EL A +
Sbjct: 1669 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1728
Query: 476 RHCEQD 481
R +QD
Sbjct: 1729 RQAQQD 1734
Score = 53.1 bits (126), Expect = 8e-07
Identities = 89/422 (21%), Positives = 164/422 (38%), Gaps = 72/422 (17%)
Query: 119 PGTPVYREKEDMYDEIIELKKSLHVQKS---DVDLMRTKLRRLEEENSRKDRQIEQLLDP 175
P V R+ E + EL+K +Q+ +V ++ ++ +LEEE +R Q+ +
Sbjct: 868 PLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAEL 927
Query: 176 SRGTDFVR-TLAEKRPDASWVINGLK---------------------QRILKLEQQCKEK 213
+ R LA ++ + V++ L+ Q I +LE + +
Sbjct: 928 CAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAE 987
Query: 214 DGTISKLQ-----TDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGA 268
+G KLQ T+ K EE + +E ++ + + LL E++
Sbjct: 988 EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKV 1047
Query: 269 KRQKKMG-------SALLSLSRSVQELTEENQSLKEDLDRVLST-SPTISKTQGYVEWSK 320
K K+ + + R ++ +E + LK LD S + + Q E +
Sbjct: 1048 KSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR 1107
Query: 321 PRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALH------------RQPRG 368
+L R+ EL+ L+ E A+ ++S A A + A + R
Sbjct: 1108 AQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1167
Query: 369 DRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLL---------------------- 406
D ++ E LRG + D + A QE +R+ EV +L
Sbjct: 1168 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1227
Query: 407 QAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQ 466
QA +L ++LE AR G+ + L E+ L ++L LQ ++E ++ + + Q
Sbjct: 1228 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1287
Query: 467 EL 468
E+
Sbjct: 1288 EV 1289
Score = 45.8 bits (107), Expect = 1e-04
Identities = 88/390 (22%), Positives = 152/390 (38%), Gaps = 84/390 (21%)
Query: 156 RRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDG 215
RR + +D ++E+ D R + A K+ + + LK ++ Q +E
Sbjct: 1615 RRRQLAKQLRDAEVER--DEERKQRTLAVAARKKLEGE--LEELKAQMASAGQGKEEAVK 1670
Query: 216 TISKLQTDMKTT--NLEEMRIAMETYYE--------------EVHRLQTLLASSETTGKK 259
+ K+Q MK +EE R + E + EV RLQ LA+S+ ++
Sbjct: 1671 QLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQ 1730
Query: 260 PLGEKKTGAKRQKKMG---SALLSLSRSVQ-------ELTEENQSLKEDLD--------R 301
++ A +A+L R ++ E EE QS E L+ +
Sbjct: 1731 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1790
Query: 302 VLSTSPTISKTQGY---VEWSKPRLLRRIVELEKKL---------------SVMESSKSH 343
V S + +S + + E + +L R+I EL +L + +ES +
Sbjct: 1791 VESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQ 1850
Query: 344 AAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTA---LQEQLLQRDL 400
A E + + S + R + RL+ V ++EER L++QL + +L
Sbjct: 1851 AEEQLEQETRERILSGKLVRRAEK--------RLKEVVLQVEEERRVADQLRDQLEKGNL 1902
Query: 401 EVKQLLQAKADLEKELECAREGE-------EERREREEVLREEIQTLTSKLQE------- 446
VKQL + + E+E A+ G E+ E E + E+ TL ++L+
Sbjct: 1903 RVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTT 1962
Query: 447 ---LQEMKKEEKEDCPEVPHKAQELPAPTP 473
Q + EE E +AQ P+P
Sbjct: 1963 RTVRQVFRLEEGVASDEEAEEAQPGSGPSP 1992
Score = 45.1 bits (105), Expect = 2e-04
Identities = 94/450 (20%), Positives = 177/450 (39%), Gaps = 65/450 (14%)
Query: 125 REKEDMYDEIIELKKSLHVQKSDV-DLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVR 183
R++E E+ +LK+ L + S++ + M + +R EE ++ R+ E+L
Sbjct: 1069 RKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQ---------A 1119
Query: 184 TLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEV 243
LA + G + ++LK +E +++ Q D+++ + + A + +
Sbjct: 1120 ALARAEDEG-----GARAQLLK---SLREAQAALAEAQEDLESERVARTK-AEKQRRDLG 1170
Query: 244 HRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSR-------SVQELTEENQSLK 296
L+ L E T +++ +KR++++ +L +VQEL + +
Sbjct: 1171 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL 1230
Query: 297 EDLDRVLSTSPTISKTQGYVEWSKPRLL--RRIVELEKKLSVMESSKSHAAEPVRSHPPA 354
+L L + +G W K RL + EL +LS +++++ + R
Sbjct: 1231 GELAEQLEQA-----RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE-- 1283
Query: 355 CLASSSALHRQPRGDRNKDH--ERLRGAVRDLKEERTALQE------------------- 393
L R G+R + E+L+ A +L+ AL E
Sbjct: 1284 -LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQL 1342
Query: 394 ----QLLQRDLEVKQLLQAKAD-LEKELECAREGEEERREREEVLREEIQTLTSKLQELQ 448
+LLQ + K L ++ +E E RE EE E E+QT ++L E +
Sbjct: 1343 HDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWR 1402
Query: 449 EMKKEEKE--DCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRD-A 505
++EE + E + A + R E+ D E G R + D D
Sbjct: 1403 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE 1462
Query: 506 AARVLQAQWKVYKHKKKKAVLDEAAVVLQA 535
R L + + + K + + +E A VL+A
Sbjct: 1463 QQRQLVSTLEKKQRKFDQLLAEEKAAVLRA 1492
Score = 43.1 bits (100), Expect = 8e-04
Identities = 78/382 (20%), Positives = 159/382 (41%), Gaps = 60/382 (15%)
Query: 127 KEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEE-NSRKDRQIE-----QLLDPSR--- 177
K+D+ + EL+++ V + + +R ++ LE+E + +D ++ Q L
Sbjct: 1545 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1604
Query: 178 -------GTDFVRTLAEKRPDASWVIN-GLKQRILKLEQQCKEKDGTISKLQTDMKTT-- 227
G + R LA++ DA + KQR L + + K+ +G + +L+ M +
Sbjct: 1605 LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAAR-KKLEGELEELKAQMASAGQ 1663
Query: 228 -------NLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLS 280
L +M+ M+ + EV + T+ ++ + + KR K + + +L
Sbjct: 1664 GKEEAVKQLRKMQAQMKELWREVE-------ETRTSREEIFSQNRESEKRLKGLEAEVLR 1716
Query: 281 LSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELE--------- 331
L + + ++D D + + ++ + K +L R+ +LE
Sbjct: 1717 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN 1776
Query: 332 --------KKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRD 383
+KL + S + RS + L RQ + R + E GA
Sbjct: 1777 SELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR 1836
Query: 384 LKEERTALQEQLLQRDLEVKQ-----LLQAK--ADLEKEL-ECAREGEEERREREEVLRE 435
K AL+ +L Q + +++Q +L K EK L E + EEERR ++ LR+
Sbjct: 1837 HKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQ-LRD 1895
Query: 436 EIQTLTSKLQELQEMKKEEKED 457
+++ ++++L+ +E +E+
Sbjct: 1896 QLEKGNLRVKQLKRQLEEAEEE 1917
Score = 42.0 bits (97), Expect = 0.002
Identities = 60/315 (19%), Positives = 122/315 (38%), Gaps = 23/315 (7%)
Query: 158 LEEENSRKDRQIEQLLDPSRGTD-FVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGT 216
LE +N ++E LL V L A N L+ ++ +LE + +
Sbjct: 1527 LERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDA 1586
Query: 217 ISKLQTD---MKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKK 273
+L+ +KT + +++ E E +L L +E + ++ +KK
Sbjct: 1587 KLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKK 1646
Query: 274 MGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKK 333
+ L L + + + + L ++ + + + S+ + + E EK+
Sbjct: 1647 LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKR 1706
Query: 334 LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
L +E+ E LA+S RQ + DR++ + V + + A+ E
Sbjct: 1707 LKGLEAEVLRLQEE--------LAASDRARRQAQQDRDE----MADEVANGNLSKAAILE 1754
Query: 394 QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
E +QL LE+ELE + E +R L ++++LT++L + +
Sbjct: 1755 -------EKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAK 1807
Query: 454 EKEDCPEVPHKAQEL 468
+ ++ + QEL
Sbjct: 1808 AESGRQQLERQIQEL 1822
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 68.6 bits (166), Expect = 2e-11
Identities = 83/366 (22%), Positives = 156/366 (42%), Gaps = 48/366 (13%)
Query: 157 RLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILK----LEQQCKE 212
+LEEE + ++R +L R E+ A ++R + L Q+ E
Sbjct: 1368 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAE 1427
Query: 213 KDGTISKLQT---------DMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGE 263
K T+ +L+ D T +LE+ R + T ++ + LLA + + + E
Sbjct: 1428 KTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEE 1487
Query: 264 KKTGAKRQKKMGSALLSLSRSV-------QELTEENQSLKEDLDRVLSTSPTISKTQ--- 313
++ ++ + LSL+R++ +EL +N++L+ +L+ +LS+ + K+
Sbjct: 1488 RERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHEL 1547
Query: 314 ----GYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGD 369
E + L ++ ELE +L+ E +K V+ A + R +G
Sbjct: 1548 ERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQ-------ALKTQHERDLQGR 1600
Query: 370 RNKDHERLRGAVRDLKEERTALQEQLLQRDLEV---KQLLQAKADLEKELECAREGEEE- 425
ER R + L++ E+ QR L V K+L +L+ ++ A +G+EE
Sbjct: 1601 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1660
Query: 426 -------RREREEVLREEIQTLTSK---LQELQEMKKEEKEDCPEVPHKAQELPAPTPSS 475
+ + +E+ RE +T TS+ + +E +K K EV +EL A +
Sbjct: 1661 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1720
Query: 476 RHCEQD 481
R +QD
Sbjct: 1721 RQAQQD 1726
Score = 53.1 bits (126), Expect = 8e-07
Identities = 89/422 (21%), Positives = 164/422 (38%), Gaps = 72/422 (17%)
Query: 119 PGTPVYREKEDMYDEIIELKKSLHVQKS---DVDLMRTKLRRLEEENSRKDRQIEQLLDP 175
P V R+ E + EL+K +Q+ +V ++ ++ +LEEE +R Q+ +
Sbjct: 860 PLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAEL 919
Query: 176 SRGTDFVR-TLAEKRPDASWVINGLK---------------------QRILKLEQQCKEK 213
+ R LA ++ + V++ L+ Q I +LE + +
Sbjct: 920 CAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAE 979
Query: 214 DGTISKLQ-----TDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGA 268
+G KLQ T+ K EE + +E ++ + + LL E++
Sbjct: 980 EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKV 1039
Query: 269 KRQKKMG-------SALLSLSRSVQELTEENQSLKEDLDRVLST-SPTISKTQGYVEWSK 320
K K+ + + R ++ +E + LK LD S + + Q E +
Sbjct: 1040 KSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR 1099
Query: 321 PRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALH------------RQPRG 368
+L R+ EL+ L+ E A+ ++S A A + A + R
Sbjct: 1100 AQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1159
Query: 369 DRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLL---------------------- 406
D ++ E LRG + D + A QE +R+ EV +L
Sbjct: 1160 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1219
Query: 407 QAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQ 466
QA +L ++LE AR G+ + L E+ L ++L LQ ++E ++ + + Q
Sbjct: 1220 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1279
Query: 467 EL 468
E+
Sbjct: 1280 EV 1281
Score = 45.8 bits (107), Expect = 1e-04
Identities = 88/390 (22%), Positives = 152/390 (38%), Gaps = 84/390 (21%)
Query: 156 RRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDG 215
RR + +D ++E+ D R + A K+ + + LK ++ Q +E
Sbjct: 1607 RRRQLAKQLRDAEVER--DEERKQRTLAVAARKKLEGE--LEELKAQMASAGQGKEEAVK 1662
Query: 216 TISKLQTDMKTT--NLEEMRIAMETYYE--------------EVHRLQTLLASSETTGKK 259
+ K+Q MK +EE R + E + EV RLQ LA+S+ ++
Sbjct: 1663 QLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQ 1722
Query: 260 PLGEKKTGAKRQKKMG---SALLSLSRSVQ-------ELTEENQSLKEDLD--------R 301
++ A +A+L R ++ E EE QS E L+ +
Sbjct: 1723 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1782
Query: 302 VLSTSPTISKTQGY---VEWSKPRLLRRIVELEKKL---------------SVMESSKSH 343
V S + +S + + E + +L R+I EL +L + +ES +
Sbjct: 1783 VESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQ 1842
Query: 344 AAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTA---LQEQLLQRDL 400
A E + + S + R + RL+ V ++EER L++QL + +L
Sbjct: 1843 AEEQLEQETRERILSGKLVRRAEK--------RLKEVVLQVEEERRVADQLRDQLEKGNL 1894
Query: 401 EVKQLLQAKADLEKELECAREGE-------EERREREEVLREEIQTLTSKLQE------- 446
VKQL + + E+E A+ G E+ E E + E+ TL ++L+
Sbjct: 1895 RVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTT 1954
Query: 447 ---LQEMKKEEKEDCPEVPHKAQELPAPTP 473
Q + EE E +AQ P+P
Sbjct: 1955 RTVRQVFRLEEGVASDEEAEEAQPGSGPSP 1984
Score = 45.1 bits (105), Expect = 2e-04
Identities = 94/450 (20%), Positives = 177/450 (39%), Gaps = 65/450 (14%)
Query: 125 REKEDMYDEIIELKKSLHVQKSDV-DLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVR 183
R++E E+ +LK+ L + S++ + M + +R EE ++ R+ E+L
Sbjct: 1061 RKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQ---------A 1111
Query: 184 TLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEV 243
LA + G + ++LK +E +++ Q D+++ + + A + +
Sbjct: 1112 ALARAEDEG-----GARAQLLK---SLREAQAALAEAQEDLESERVARTK-AEKQRRDLG 1162
Query: 244 HRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSR-------SVQELTEENQSLK 296
L+ L E T +++ +KR++++ +L +VQEL + +
Sbjct: 1163 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL 1222
Query: 297 EDLDRVLSTSPTISKTQGYVEWSKPRLL--RRIVELEKKLSVMESSKSHAAEPVRSHPPA 354
+L L + +G W K RL + EL +LS +++++ + R
Sbjct: 1223 GELAEQLEQA-----RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE-- 1275
Query: 355 CLASSSALHRQPRGDRNKDH--ERLRGAVRDLKEERTALQE------------------- 393
L R G+R + E+L+ A +L+ AL E
Sbjct: 1276 -LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQL 1334
Query: 394 ----QLLQRDLEVKQLLQAKAD-LEKELECAREGEEERREREEVLREEIQTLTSKLQELQ 448
+LLQ + K L ++ +E E RE EE E E+QT ++L E +
Sbjct: 1335 HDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWR 1394
Query: 449 EMKKEEKE--DCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRD-A 505
++EE + E + A + R E+ D E G R + D D
Sbjct: 1395 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE 1454
Query: 506 AARVLQAQWKVYKHKKKKAVLDEAAVVLQA 535
R L + + + K + + +E A VL+A
Sbjct: 1455 QQRQLVSTLEKKQRKFDQLLAEEKAAVLRA 1484
Score = 43.1 bits (100), Expect = 8e-04
Identities = 78/382 (20%), Positives = 159/382 (41%), Gaps = 60/382 (15%)
Query: 127 KEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEE-NSRKDRQIE-----QLLDPSR--- 177
K+D+ + EL+++ V + + +R ++ LE+E + +D ++ Q L
Sbjct: 1537 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1596
Query: 178 -------GTDFVRTLAEKRPDASWVIN-GLKQRILKLEQQCKEKDGTISKLQTDMKTT-- 227
G + R LA++ DA + KQR L + + K+ +G + +L+ M +
Sbjct: 1597 LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAAR-KKLEGELEELKAQMASAGQ 1655
Query: 228 -------NLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLS 280
L +M+ M+ + EV + T+ ++ + + KR K + + +L
Sbjct: 1656 GKEEAVKQLRKMQAQMKELWREVE-------ETRTSREEIFSQNRESEKRLKGLEAEVLR 1708
Query: 281 LSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELE--------- 331
L + + ++D D + + ++ + K +L R+ +LE
Sbjct: 1709 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN 1768
Query: 332 --------KKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRD 383
+KL + S + RS + L RQ + R + E GA
Sbjct: 1769 SELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR 1828
Query: 384 LKEERTALQEQLLQRDLEVKQ-----LLQAK--ADLEKEL-ECAREGEEERREREEVLRE 435
K AL+ +L Q + +++Q +L K EK L E + EEERR ++ LR+
Sbjct: 1829 HKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQ-LRD 1887
Query: 436 EIQTLTSKLQELQEMKKEEKED 457
+++ ++++L+ +E +E+
Sbjct: 1888 QLEKGNLRVKQLKRQLEEAEEE 1909
Score = 42.0 bits (97), Expect = 0.002
Identities = 60/315 (19%), Positives = 122/315 (38%), Gaps = 23/315 (7%)
Query: 158 LEEENSRKDRQIEQLLDPSRGTD-FVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGT 216
LE +N ++E LL V L A N L+ ++ +LE + +
Sbjct: 1519 LERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDA 1578
Query: 217 ISKLQTD---MKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKK 273
+L+ +KT + +++ E E +L L +E + ++ +KK
Sbjct: 1579 KLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKK 1638
Query: 274 MGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKK 333
+ L L + + + + L ++ + + + S+ + + E EK+
Sbjct: 1639 LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKR 1698
Query: 334 LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
L +E+ E LA+S RQ + DR++ + V + + A+ E
Sbjct: 1699 LKGLEAEVLRLQEE--------LAASDRARRQAQQDRDE----MADEVANGNLSKAAILE 1746
Query: 394 QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
E +QL LE+ELE + E +R L ++++LT++L + +
Sbjct: 1747 -------EKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAK 1799
Query: 454 EKEDCPEVPHKAQEL 468
+ ++ + QEL
Sbjct: 1800 AESGRQQLERQIQEL 1814
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 68.6 bits (166), Expect = 2e-11
Identities = 83/366 (22%), Positives = 156/366 (42%), Gaps = 48/366 (13%)
Query: 157 RLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILK----LEQQCKE 212
+LEEE + ++R +L R E+ A ++R + L Q+ E
Sbjct: 1409 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAE 1468
Query: 213 KDGTISKLQT---------DMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGE 263
K T+ +L+ D T +LE+ R + T ++ + LLA + + + E
Sbjct: 1469 KTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEE 1528
Query: 264 KKTGAKRQKKMGSALLSLSRSV-------QELTEENQSLKEDLDRVLSTSPTISKTQ--- 313
++ ++ + LSL+R++ +EL +N++L+ +L+ +LS+ + K+
Sbjct: 1529 RERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHEL 1588
Query: 314 ----GYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGD 369
E + L ++ ELE +L+ E +K V+ A + R +G
Sbjct: 1589 ERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQ-------ALKTQHERDLQGR 1641
Query: 370 RNKDHERLRGAVRDLKEERTALQEQLLQRDLEV---KQLLQAKADLEKELECAREGEEE- 425
ER R + L++ E+ QR L V K+L +L+ ++ A +G+EE
Sbjct: 1642 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1701
Query: 426 -------RREREEVLREEIQTLTSK---LQELQEMKKEEKEDCPEVPHKAQELPAPTPSS 475
+ + +E+ RE +T TS+ + +E +K K EV +EL A +
Sbjct: 1702 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1761
Query: 476 RHCEQD 481
R +QD
Sbjct: 1762 RQAQQD 1767
Score = 53.1 bits (126), Expect = 8e-07
Identities = 89/422 (21%), Positives = 164/422 (38%), Gaps = 72/422 (17%)
Query: 119 PGTPVYREKEDMYDEIIELKKSLHVQKS---DVDLMRTKLRRLEEENSRKDRQIEQLLDP 175
P V R+ E + EL+K +Q+ +V ++ ++ +LEEE +R Q+ +
Sbjct: 901 PLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAEL 960
Query: 176 SRGTDFVR-TLAEKRPDASWVINGLK---------------------QRILKLEQQCKEK 213
+ R LA ++ + V++ L+ Q I +LE + +
Sbjct: 961 CAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAE 1020
Query: 214 DGTISKLQ-----TDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGA 268
+G KLQ T+ K EE + +E ++ + + LL E++
Sbjct: 1021 EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKV 1080
Query: 269 KRQKKMG-------SALLSLSRSVQELTEENQSLKEDLDRVLST-SPTISKTQGYVEWSK 320
K K+ + + R ++ +E + LK LD S + + Q E +
Sbjct: 1081 KSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR 1140
Query: 321 PRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALH------------RQPRG 368
+L R+ EL+ L+ E A+ ++S A A + A + R
Sbjct: 1141 AQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1200
Query: 369 DRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLL---------------------- 406
D ++ E LRG + D + A QE +R+ EV +L
Sbjct: 1201 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1260
Query: 407 QAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQ 466
QA +L ++LE AR G+ + L E+ L ++L LQ ++E ++ + + Q
Sbjct: 1261 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1320
Query: 467 EL 468
E+
Sbjct: 1321 EV 1322
Score = 45.8 bits (107), Expect = 1e-04
Identities = 88/390 (22%), Positives = 152/390 (38%), Gaps = 84/390 (21%)
Query: 156 RRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDG 215
RR + +D ++E+ D R + A K+ + + LK ++ Q +E
Sbjct: 1648 RRRQLAKQLRDAEVER--DEERKQRTLAVAARKKLEGE--LEELKAQMASAGQGKEEAVK 1703
Query: 216 TISKLQTDMKTT--NLEEMRIAMETYYE--------------EVHRLQTLLASSETTGKK 259
+ K+Q MK +EE R + E + EV RLQ LA+S+ ++
Sbjct: 1704 QLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQ 1763
Query: 260 PLGEKKTGAKRQKKMG---SALLSLSRSVQ-------ELTEENQSLKEDLD--------R 301
++ A +A+L R ++ E EE QS E L+ +
Sbjct: 1764 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1823
Query: 302 VLSTSPTISKTQGY---VEWSKPRLLRRIVELEKKL---------------SVMESSKSH 343
V S + +S + + E + +L R+I EL +L + +ES +
Sbjct: 1824 VESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQ 1883
Query: 344 AAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTA---LQEQLLQRDL 400
A E + + S + R + RL+ V ++EER L++QL + +L
Sbjct: 1884 AEEQLEQETRERILSGKLVRRAEK--------RLKEVVLQVEEERRVADQLRDQLEKGNL 1935
Query: 401 EVKQLLQAKADLEKELECAREGE-------EERREREEVLREEIQTLTSKLQE------- 446
VKQL + + E+E A+ G E+ E E + E+ TL ++L+
Sbjct: 1936 RVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTT 1995
Query: 447 ---LQEMKKEEKEDCPEVPHKAQELPAPTP 473
Q + EE E +AQ P+P
Sbjct: 1996 RTVRQVFRLEEGVASDEEAEEAQPGSGPSP 2025
Score = 45.1 bits (105), Expect = 2e-04
Identities = 94/450 (20%), Positives = 177/450 (39%), Gaps = 65/450 (14%)
Query: 125 REKEDMYDEIIELKKSLHVQKSDV-DLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVR 183
R++E E+ +LK+ L + S++ + M + +R EE ++ R+ E+L
Sbjct: 1102 RKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQ---------A 1152
Query: 184 TLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEV 243
LA + G + ++LK +E +++ Q D+++ + + A + +
Sbjct: 1153 ALARAEDEG-----GARAQLLK---SLREAQAALAEAQEDLESERVARTK-AEKQRRDLG 1203
Query: 244 HRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSR-------SVQELTEENQSLK 296
L+ L E T +++ +KR++++ +L +VQEL + +
Sbjct: 1204 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL 1263
Query: 297 EDLDRVLSTSPTISKTQGYVEWSKPRLL--RRIVELEKKLSVMESSKSHAAEPVRSHPPA 354
+L L + +G W K RL + EL +LS +++++ + R
Sbjct: 1264 GELAEQLEQA-----RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE-- 1316
Query: 355 CLASSSALHRQPRGDRNKDH--ERLRGAVRDLKEERTALQE------------------- 393
L R G+R + E+L+ A +L+ AL E
Sbjct: 1317 -LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQL 1375
Query: 394 ----QLLQRDLEVKQLLQAKAD-LEKELECAREGEEERREREEVLREEIQTLTSKLQELQ 448
+LLQ + K L ++ +E E RE EE E E+QT ++L E +
Sbjct: 1376 HDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWR 1435
Query: 449 EMKKEEKE--DCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRD-A 505
++EE + E + A + R E+ D E G R + D D
Sbjct: 1436 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE 1495
Query: 506 AARVLQAQWKVYKHKKKKAVLDEAAVVLQA 535
R L + + + K + + +E A VL+A
Sbjct: 1496 QQRQLVSTLEKKQRKFDQLLAEEKAAVLRA 1525
Score = 43.1 bits (100), Expect = 8e-04
Identities = 78/382 (20%), Positives = 159/382 (41%), Gaps = 60/382 (15%)
Query: 127 KEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEE-NSRKDRQIE-----QLLDPSR--- 177
K+D+ + EL+++ V + + +R ++ LE+E + +D ++ Q L
Sbjct: 1578 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1637
Query: 178 -------GTDFVRTLAEKRPDASWVIN-GLKQRILKLEQQCKEKDGTISKLQTDMKTT-- 227
G + R LA++ DA + KQR L + + K+ +G + +L+ M +
Sbjct: 1638 LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAAR-KKLEGELEELKAQMASAGQ 1696
Query: 228 -------NLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLS 280
L +M+ M+ + EV + T+ ++ + + KR K + + +L
Sbjct: 1697 GKEEAVKQLRKMQAQMKELWREVE-------ETRTSREEIFSQNRESEKRLKGLEAEVLR 1749
Query: 281 LSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELE--------- 331
L + + ++D D + + ++ + K +L R+ +LE
Sbjct: 1750 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN 1809
Query: 332 --------KKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRD 383
+KL + S + RS + L RQ + R + E GA
Sbjct: 1810 SELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR 1869
Query: 384 LKEERTALQEQLLQRDLEVKQ-----LLQAK--ADLEKEL-ECAREGEEERREREEVLRE 435
K AL+ +L Q + +++Q +L K EK L E + EEERR ++ LR+
Sbjct: 1870 HKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQ-LRD 1928
Query: 436 EIQTLTSKLQELQEMKKEEKED 457
+++ ++++L+ +E +E+
Sbjct: 1929 QLEKGNLRVKQLKRQLEEAEEE 1950
Score = 42.0 bits (97), Expect = 0.002
Identities = 60/315 (19%), Positives = 122/315 (38%), Gaps = 23/315 (7%)
Query: 158 LEEENSRKDRQIEQLLDPSRGTD-FVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGT 216
LE +N ++E LL V L A N L+ ++ +LE + +
Sbjct: 1560 LERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDA 1619
Query: 217 ISKLQTD---MKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKK 273
+L+ +KT + +++ E E +L L +E + ++ +KK
Sbjct: 1620 KLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKK 1679
Query: 274 MGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKK 333
+ L L + + + + L ++ + + + S+ + + E EK+
Sbjct: 1680 LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKR 1739
Query: 334 LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
L +E+ E LA+S RQ + DR++ + V + + A+ E
Sbjct: 1740 LKGLEAEVLRLQEE--------LAASDRARRQAQQDRDE----MADEVANGNLSKAAILE 1787
Query: 394 QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
E +QL LE+ELE + E +R L ++++LT++L + +
Sbjct: 1788 -------EKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAK 1840
Query: 454 EKEDCPEVPHKAQEL 468
+ ++ + QEL
Sbjct: 1841 AESGRQQLERQIQEL 1855
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 67.4 bits (163), Expect = 4e-11
Identities = 81/394 (20%), Positives = 170/394 (43%), Gaps = 39/394 (9%)
Query: 125 REKEDMYDEIIELKKSLHVQKSDVDLMRTKLR-RLEEENSRK---DRQIEQL-------- 172
++ +++ E K SL + V+ + R +LEEE K ++QI L
Sbjct: 1311 QDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMK 1370
Query: 173 --LDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKT--TN 228
++ S G + T E + + GL QR + + + T ++LQ ++ +
Sbjct: 1371 KKMEDSVGC--LETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVD 1428
Query: 229 LEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQEL 288
L+ R + ++ + LLA +T K E+ ++ + LSL+R+++E
Sbjct: 1429 LDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEA 1488
Query: 289 TEE-------NQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSK 341
E+ N+ + +++ ++S+ + K+ +E SK L +++ E++ +L +E
Sbjct: 1489 MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL 1548
Query: 342 SHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLE 401
+ A + R +G + E+ + VR ++E L+++ QR +
Sbjct: 1549 QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMA 1608
Query: 402 V---KQLLQAKADLEKELECAREGEEE--------RREREEVLREEIQTLTSK---LQEL 447
V K+L DLE ++ A + +E + + ++ +RE T S+ L +
Sbjct: 1609 VAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQA 1668
Query: 448 QEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQD 481
+E +K+ K E+ +EL A + R +Q+
Sbjct: 1669 KENEKKLKSMEAEMIQLQEELAAAERAKRQAQQE 1702
Score = 57.0 bits (136), Expect = 6e-08
Identities = 69/341 (20%), Positives = 134/341 (39%), Gaps = 56/341 (16%)
Query: 119 PGTPVYREKEDMY---DEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDP 175
P V R++E+M +E++++++ ++ + M T +L E + Q++ +
Sbjct: 836 PLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETEL 895
Query: 176 SRGTDFVRT-LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRI 234
+ +R L K+ + + + L+ R+ + E++C+ K+Q
Sbjct: 896 CAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQ------------- 942
Query: 235 AMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQS 294
+ + L+ L E+ +K EK T + KK+ EE Q
Sbjct: 943 ------QNIQELEEQLEEEESARQKLQLEKVTTEAKLKKL---------------EEEQI 981
Query: 295 LKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPA 354
+ ED + L+ K L RI E L+ E A+ H
Sbjct: 982 ILEDQNCKLAKE-------------KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM 1028
Query: 355 CLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEK 414
L R+ K + L R L+ + T L +Q+ + ++ +L A E+
Sbjct: 1029 ITDLEERLRRE-----EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEE 1083
Query: 415 ELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEK 455
EL+ A EE ++ + ++I+ L S++ ELQE + E+
Sbjct: 1084 ELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124
Score = 55.8 bits (133), Expect = 1e-07
Identities = 77/354 (21%), Positives = 158/354 (44%), Gaps = 33/354 (9%)
Query: 199 LKQRILKLEQQCKEKDGTISKLQ-----TDMKTTNLEEMRIAMETYY----EEVHRLQTL 249
++Q I +LE+Q +E++ KLQ T+ K LEE +I +E +E L+
Sbjct: 941 MQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDR 1000
Query: 250 LASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRV----LST 305
+A T + + K+ AK + K + + L ++ ++ Q L++ ++
Sbjct: 1001 IAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDL 1060
Query: 306 SPTISKTQGYVEWSKPRLLRRIVELEKKLSVME---SSKSHAAEPVRSHPPACLASSSAL 362
S I++ Q + K +L ++ EL+ L+ +E + K+ A + +R L
Sbjct: 1061 SDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDL 1120
Query: 363 HRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREG 422
+ R RNK ++ R DL EE AL+ +L + L + A ++EL RE
Sbjct: 1121 ESE-RASRNKAEKQKR----DLGEELEALKTEL-------EDTLDSTA-AQQELRSKRE- 1166
Query: 423 EEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQDW 482
+E ++ L EE +T +++QE+++ + E+ E + + + A ++ ++
Sbjct: 1167 -QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE 1225
Query: 483 PPDSSEE--GLPRPRSPCSDGRRDAAARVLQAQWKVYKHKKKKAVLDEAAVVLQ 534
+ + E L + + R+ A++ + Q K + ++ + L + LQ
Sbjct: 1226 RGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQ 1279
Score = 50.4 bits (119), Expect = 5e-06
Identities = 68/354 (19%), Positives = 153/354 (43%), Gaps = 35/354 (9%)
Query: 126 EKEDMYDEIIELKKSLHVQKSDV----DLMRTKLRRLEEENSRKDRQIEQLLD-PSRGTD 180
+ D+ D+I EL+ + K + + ++ L R+EEE ++K+ ++++ + S+ ++
Sbjct: 1056 DSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE 1115
Query: 181 FVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMK-----TTNLEEMRIA 235
L +R + K E+Q ++ + L+T+++ T +E+R
Sbjct: 1116 LQEDLESERASRN-----------KAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSK 1164
Query: 236 METYYEEVHRLQTLLASSETTGKKPLGE-KKTGAKRQKKMGSALLSLSRSVQELTEENQS 294
E +EV+ L+ L T + + E ++ ++ +++ L R L + Q+
Sbjct: 1165 RE---QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT 1221
Query: 295 LKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPA 354
L+ + + + + + +G E + ++ ++ EL+ K + E ++ A+ V
Sbjct: 1222 LENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVE 1281
Query: 355 CLASSSALHRQPRGDRN--KDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADL 412
+ L + KD L ++D +E Q L ++KQ +
Sbjct: 1282 LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQ-------V 1334
Query: 413 EKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQ 466
E E RE EE E + L ++I TL +++ ++++ K E+ C E + +
Sbjct: 1335 EDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKK-KMEDSVGCLETAEEVK 1387
Score = 49.7 bits (117), Expect = 9e-06
Identities = 65/373 (17%), Positives = 151/373 (40%), Gaps = 42/373 (11%)
Query: 127 KEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEE-NSRKDRQIE-----QLLDPSRGTD 180
K+D+ + EL+KS + V+ M+T+L LE+E + +D ++ Q + D
Sbjct: 1513 KDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERD 1572
Query: 181 FVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTIS---KLQTDMK--TTNLEEMRIA 235
+ ++ +++ +LE + K++ ++ KL+ D+K +++
Sbjct: 1573 LQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN 1632
Query: 236 METYYEEVHRLQTL-------LASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQEL 288
+ +++ +LQ L + + ++ L + K K+ K M + ++ L +
Sbjct: 1633 RDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAA 1692
Query: 289 TEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPV 348
+ +++ D + S K RL RI +LE++L + + + +
Sbjct: 1693 ERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRL 1752
Query: 349 -----------------RSHPPACLASSSALHRQPRGDRNKDHE-------RLRGAVRDL 384
RSH + L RQ + + K E + + ++ L
Sbjct: 1753 KKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITAL 1812
Query: 385 KEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKL 444
+ + L+EQL E + + EK+L+ ++ R E +++ +++L
Sbjct: 1813 EAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRL 1872
Query: 445 QELQEMKKEEKED 457
++L+ +E +E+
Sbjct: 1873 KQLKRQLEEAEEE 1885
Score = 35.8 bits (81), Expect = 0.13
Identities = 29/100 (29%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 372 KDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREG-EEERRERE 430
K E+ A L E T LQ QL+ L++++ LQA+ +L E E R +++E E
Sbjct: 856 KVREKQLAAENRLTEMET-LQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELE 914
Query: 431 EV---LREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
E+ L ++ + Q LQ KK+ +++ E+ + +E
Sbjct: 915 EICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE 954
Score = 32.3 bits (72), Expect = 1.5
Identities = 19/85 (22%), Positives = 42/85 (49%)
Query: 384 LKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSK 443
++E++ A + +L + + QL+ K L+++L+ E E E L + Q L
Sbjct: 857 VREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEI 916
Query: 444 LQELQEMKKEEKEDCPEVPHKAQEL 468
+L+ +EE+E C + + +++
Sbjct: 917 CHDLEARVEEEEERCQHLQAEKKKM 941
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 66.6 bits (161), Expect = 7e-11
Identities = 77/363 (21%), Positives = 155/363 (42%), Gaps = 41/363 (11%)
Query: 125 REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
R+KE + E KSL ++ D T L LEE + K+R IE+L + R D R
Sbjct: 588 RDKEKQMSSLKERVKSLQADTTNTD---TALTTLEEALAEKERTIERLKE-QRDRD-ERE 642
Query: 185 LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTD---------MKTTNLEEMRIA 235
E+ + + LK+++ L+ EK+ ++ L+ K + L+ + IA
Sbjct: 643 KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIA 702
Query: 236 METYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSL 295
+E EE ++++ L K E A+ +M + L R + +E+
Sbjct: 703 LEQKKEECLKMESQL--------KKAHEAALEARASPEMSDRIQHLEREITRYKDESSKA 754
Query: 296 KEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPAC 355
+ ++DR+L + + + L R++ + KK++ ++ E V A
Sbjct: 755 QAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK-----EQVEKKKSAQ 809
Query: 356 LASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQL-------LQRDLEVKQLLQA 408
+ + R+ + N ++L+ ++R + L+E L +R++ + Q A
Sbjct: 810 MLEEA---RRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESA 866
Query: 409 KADLEKELECAREGEEERREREEVLREEI----QTLTSKLQELQEMKKEEKEDCPEVPHK 464
+ + EK++E E+ ++ E ++ ++ Q+L K L ++ E ++ EV
Sbjct: 867 RTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEM 926
Query: 465 AQE 467
QE
Sbjct: 927 KQE 929
Score = 60.5 bits (145), Expect = 5e-09
Identities = 77/356 (21%), Positives = 161/356 (45%), Gaps = 35/356 (9%)
Query: 136 ELKKSLHVQK---SDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEK---- 188
ELKK ++K S + + + + R ++EEN I+ L D R + L ++
Sbjct: 193 ELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSS 252
Query: 189 RPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVH-RLQ 247
R V ++ +L + + + + L+ LEEM + +ET + ++ R +
Sbjct: 253 RTGEPCVAELTEENFQRLHAEHERQAKELFLLRK-----TLEEMELRIETQKQTLNARDE 307
Query: 248 TLLASSETTGKKPLGEKKTGA--KRQKKMGSALLS---LSRSVQELTEENQSLKEDLDRV 302
++ E K L K T +R +++ A + L +++ +EN L+E++ R
Sbjct: 308 SIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRR 367
Query: 303 LSTSPTISKTQGYVEWSKPRLLRRIVEL-EKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
+P +KT + L+ ++E+ + K+S ME E ++ L S+ A
Sbjct: 368 FENAPDSAKT---------KALQTVIEMKDSKISSMERGLRDLEEEIQ-----MLKSNGA 413
Query: 362 LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
L + R + K E R + +K + L+E+L ++ + ++L + A L+ E+ ++
Sbjct: 414 LSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQ 473
Query: 422 GEEERREREEV-LREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSR 476
E R++ E + L+ +++TLT++ + ++ + KE +A L + R
Sbjct: 474 -ELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALR 528
Score = 57.4 bits (137), Expect = 4e-08
Identities = 78/366 (21%), Positives = 161/366 (43%), Gaps = 36/366 (9%)
Query: 143 VQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF--VRTLAEKRPDASWVINGLK 200
+ +++VD +R +L E ++K +QI+ + + +GT + L + +N L+
Sbjct: 519 ILQTEVDALRLRLEEKETMLNKKTKQIQDMAE-EKGTQAGEIHDLKDMLDVKERKVNVLQ 577
Query: 201 QRILKLEQQCKEKDGTISKLQTDMK-----TTNLEEMRIAMETYYEEVHRLQTLLASSET 255
++I L++Q ++K+ +S L+ +K TTN + +E E R L
Sbjct: 578 KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRD 637
Query: 256 TGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGY 315
++ E+ K+ K +SL + +L+E+ SL + + S + + G
Sbjct: 638 RDEREKQEEIDNYKKDLKDLKEKVSLLQG--DLSEKEASLLDLKEHASSLA-----SSGL 690
Query: 316 VEWSKPRLLRRIVELEKKLSV-MESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDH 374
+ S+ + L +E +K+ + MES A E + S H + R KD
Sbjct: 691 KKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDE 750
Query: 375 --------ERLRGAVRDLKEERTALQEQLLQRDLEVKQL------LQAKADLEKE----- 415
+RL +++++ E+ +++ + + +VK L+ K +EK+
Sbjct: 751 SSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM 810
Query: 416 LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPH-KAQELPAPTPS 474
LE AR E+ + + L++ ++ +++EL+E +E + E AQE A T +
Sbjct: 811 LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA 870
Query: 475 SRHCEQ 480
+ E+
Sbjct: 871 EKQVEE 876
Score = 47.8 bits (112), Expect = 3e-05
Identities = 82/396 (20%), Positives = 161/396 (40%), Gaps = 58/396 (14%)
Query: 132 DEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF---------- 181
+E E K + V +S M+ K+ +L+EE S K+ Q E+L + G
Sbjct: 417 EEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELS 476
Query: 182 ------------VRTLAEKRPDASWVINGLKQRILKLEQQC----KEKDGTISKLQ---- 221
+ TL + D+ I LK+ + EQ+ E D +L+
Sbjct: 477 RKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKET 536
Query: 222 -TDMKTTNLEEMRIAMETYYEEVHRLQTLLASSE---TTGKKPLGEKKTGAKRQKKMGSA 277
+ KT +++M T E+H L+ +L E +K + + + ++K S+
Sbjct: 537 MLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSS 596
Query: 278 LLSLSRSVQELTEENQSLKEDLDRVLS----TSPTISKTQGYVEWSKPRLL----RRIVE 329
L +S+Q T + L+ L+ T + + + E K + + + +
Sbjct: 597 LKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKD 656
Query: 330 LEKKLSVME---SSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKE 386
L++K+S+++ S K + ++ H A +SS L + R + L A+ KE
Sbjct: 657 LKEKVSLLQGDLSEKEASLLDLKEH--ASSLASSGLKKDSR------LKTLEIALEQKKE 708
Query: 387 ERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREE--VLREEIQTLTSKL 444
E ++ QL + + L+A+A E E R ++E + E+ L L
Sbjct: 709 ECLKMESQLKKAH---EAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEIL 765
Query: 445 QELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQ 480
+E++ K ++ + E+ + ++ + +H EQ
Sbjct: 766 KEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQ 801
Score = 41.2 bits (95), Expect = 0.003
Identities = 46/188 (24%), Positives = 82/188 (43%), Gaps = 31/188 (16%)
Query: 131 YDEIIELKKS---LHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAE 187
+ E +E KKS L + D + ++L++ +KD +IE+L + R + V+ AE
Sbjct: 798 HKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALR--ESVQITAE 855
Query: 188 K----------RPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDM--KTTNLEEMRIA 235
+ R +A + L + K++Q+ + +S Q + K T+L +R
Sbjct: 856 REMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE 915
Query: 236 METYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSL 295
+ EEV ++ E A +K ALL LS S ++ EE +L
Sbjct: 916 RRKHLEEVLEMKQ--------------EALLAAISEKDANIALLELSSSKKKTQEEVAAL 961
Query: 296 KEDLDRVL 303
K + DR++
Sbjct: 962 KREKDRLV 969
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 66.6 bits (161), Expect = 7e-11
Identities = 77/363 (21%), Positives = 155/363 (42%), Gaps = 41/363 (11%)
Query: 125 REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
R+KE + E KSL ++ D T L LEE + K+R IE+L + R D R
Sbjct: 560 RDKEKQMSSLKERVKSLQADTTNTD---TALTTLEEALAEKERTIERLKE-QRDRD-ERE 614
Query: 185 LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTD---------MKTTNLEEMRIA 235
E+ + + LK+++ L+ EK+ ++ L+ K + L+ + IA
Sbjct: 615 KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIA 674
Query: 236 METYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSL 295
+E EE ++++ L K E A+ +M + L R + +E+
Sbjct: 675 LEQKKEECLKMESQL--------KKAHEAALEARASPEMSDRIQHLEREITRYKDESSKA 726
Query: 296 KEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPAC 355
+ ++DR+L + + + L R++ + KK++ ++ E V A
Sbjct: 727 QAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK-----EQVEKKKSAQ 781
Query: 356 LASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQL-------LQRDLEVKQLLQA 408
+ + R+ + N ++L+ ++R + L+E L +R++ + Q A
Sbjct: 782 MLEEA---RRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESA 838
Query: 409 KADLEKELECAREGEEERREREEVLREEI----QTLTSKLQELQEMKKEEKEDCPEVPHK 464
+ + EK++E E+ ++ E ++ ++ Q+L K L ++ E ++ EV
Sbjct: 839 RTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEM 898
Query: 465 AQE 467
QE
Sbjct: 899 KQE 901
Score = 62.0 bits (149), Expect = 2e-09
Identities = 75/349 (21%), Positives = 156/349 (44%), Gaps = 43/349 (12%)
Query: 136 ELKKSLHVQK---SDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEK---- 188
ELKK ++K S + + + + R ++EEN I+ L D R + L ++
Sbjct: 193 ELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSS 252
Query: 189 RPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVH-RLQ 247
R V ++ +L + + + + L+ LEEM + +ET + ++ R +
Sbjct: 253 RTGEPCVAELTEENFQRLHAEHERQAKELFLLRK-----TLEEMELRIETQKQTLNARDE 307
Query: 248 TLLASSETTGKKPLGEKKTGA--KRQKKMGSALLS---LSRSVQELTEENQSLKEDLDRV 302
++ E K L K T +R +++ A + L +++ +EN L+E++ R
Sbjct: 308 SIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRR 367
Query: 303 LSTSPTISKTQGYVEWSKPRLLRRIVEL-EKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
+P +KT + L+ ++E+ + K+S ME E ++ L S+ A
Sbjct: 368 FENAPDSAKT---------KALQTVIEMKDSKISSMERGLRDLEEEIQ-----MLKSNGA 413
Query: 362 LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLE-------VKQLLQAKADLEK 414
L + R + K E R + +K + ++++L ++D E ++ L +D ++
Sbjct: 414 LSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQ 473
Query: 415 ELECAREGEEERREREEVLREEIQTLTSKLQELQEM---KKEEKEDCPE 460
+E +E + +R +L+ E+ L +L+E + M K ++ +D E
Sbjct: 474 HIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAE 522
Score = 57.4 bits (137), Expect = 4e-08
Identities = 78/366 (21%), Positives = 161/366 (43%), Gaps = 36/366 (9%)
Query: 143 VQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF--VRTLAEKRPDASWVINGLK 200
+ +++VD +R +L E ++K +QI+ + + +GT + L + +N L+
Sbjct: 491 ILQTEVDALRLRLEEKETMLNKKTKQIQDMAE-EKGTQAGEIHDLKDMLDVKERKVNVLQ 549
Query: 201 QRILKLEQQCKEKDGTISKLQTDMK-----TTNLEEMRIAMETYYEEVHRLQTLLASSET 255
++I L++Q ++K+ +S L+ +K TTN + +E E R L
Sbjct: 550 KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRD 609
Query: 256 TGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGY 315
++ E+ K+ K +SL + +L+E+ SL + + S + + G
Sbjct: 610 RDEREKQEEIDNYKKDLKDLKEKVSLLQG--DLSEKEASLLDLKEHASSLA-----SSGL 662
Query: 316 VEWSKPRLLRRIVELEKKLSV-MESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDH 374
+ S+ + L +E +K+ + MES A E + S H + R KD
Sbjct: 663 KKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDE 722
Query: 375 --------ERLRGAVRDLKEERTALQEQLLQRDLEVKQL------LQAKADLEKE----- 415
+RL +++++ E+ +++ + + +VK L+ K +EK+
Sbjct: 723 SSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM 782
Query: 416 LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPH-KAQELPAPTPS 474
LE AR E+ + + L++ ++ +++EL+E +E + E AQE A T +
Sbjct: 783 LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA 842
Query: 475 SRHCEQ 480
+ E+
Sbjct: 843 EKQVEE 848
Score = 41.2 bits (95), Expect = 0.003
Identities = 46/188 (24%), Positives = 82/188 (43%), Gaps = 31/188 (16%)
Query: 131 YDEIIELKKS---LHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAE 187
+ E +E KKS L + D + ++L++ +KD +IE+L + R + V+ AE
Sbjct: 770 HKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALR--ESVQITAE 827
Query: 188 K----------RPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDM--KTTNLEEMRIA 235
+ R +A + L + K++Q+ + +S Q + K T+L +R
Sbjct: 828 REMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE 887
Query: 236 METYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSL 295
+ EEV ++ E A +K ALL LS S ++ EE +L
Sbjct: 888 RRKHLEEVLEMKQ--------------EALLAAISEKDANIALLELSSSKKKTQEEVAAL 933
Query: 296 KEDLDRVL 303
K + DR++
Sbjct: 934 KREKDRLV 941
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 65.5 bits (158), Expect = 2e-10
Identities = 81/429 (18%), Positives = 178/429 (41%), Gaps = 49/429 (11%)
Query: 118 VPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR 177
+P + E + + E+ + L Q + +L ++ EE+ R++ +I++ +
Sbjct: 258 LPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEK-- 315
Query: 178 GTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAME 237
++ EK + I ++++ + E+ EK+ + + Q +M E+MR E
Sbjct: 316 ----IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR-QEEMMWEKEEKMRRLEE 370
Query: 238 TYYEEVHRLQTLLASSETTGKKPLGEKKTGA----KRQKKMGSALLSLSRSVQELTEENQ 293
+E+ +++ L K E+K + Q+K + R +++ E+ +
Sbjct: 371 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 430
Query: 294 SLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMES-----SKSHAAEPV 348
++E ++ I + + E K + + E+K+ E K H E +
Sbjct: 431 KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKI 490
Query: 349 RSHPPACLASSSALHRQPRGDRNKDH-------------ERLRGAVRDLKEERTALQEQL 395
R +H Q R ++ E++R ++E+ +QEQ
Sbjct: 491 RKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQE 550
Query: 396 LQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTL---TSKLQELQEMKK 452
++ E ++ +Q + + ++ E RE EE+ RE++E +RE+ + + K++E +EM +
Sbjct: 551 -EKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQ 609
Query: 453 EEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVLQA 512
E++E E K CEQ+ EE + R + + R+ Q
Sbjct: 610 EQEEKMWEQEEKM------------CEQEEKMQEQEEKMRRQ----EEKMWEQEVRLRQQ 653
Query: 513 QWKVYKHKK 521
+ K+ +H++
Sbjct: 654 EEKMQEHQE 662
Score = 33.1 bits (74), Expect = 0.87
Identities = 48/176 (27%), Positives = 70/176 (39%), Gaps = 55/176 (31%)
Query: 329 ELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEER 388
ELE+ LS + + K A + A S L+R D +LKE+
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDE------------ELKEKN 223
Query: 389 TALQEQL----------------LQRDLE------VKQLLQAKAD-LEKELECA------ 419
LQE+L L+R LE +Q LQA+AD L KEL+
Sbjct: 224 AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA 283
Query: 420 -----------REGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHK 464
+ +EE+ R+E E+IQ K+QE +E +E++E E K
Sbjct: 284 QVEENELWNRLNQQQEEKMWRQE---EKIQEWEEKIQEQEEKIREQEEKIREQEEK 336
>gi|50083293 coiled-coil domain containing 123 [Homo sapiens]
Length = 783
Score = 63.2 bits (152), Expect = 8e-10
Identities = 73/318 (22%), Positives = 140/318 (44%), Gaps = 35/318 (11%)
Query: 125 REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
++ +++ DE LK ++H ++ +TK R L +E S IE L PS+G
Sbjct: 306 KQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLN---IEGL--PSKG------ 354
Query: 185 LAEKRPDASWV--INGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEE 242
P W+ I L +L E KEKD + L+ +M+ + + E EE
Sbjct: 355 -----PIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKEN--EE 407
Query: 243 VHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRV 302
+H Q L SS T ++ + +T AK + LL ++L + + K+
Sbjct: 408 LH--QELNKSSAVTSEE-WRQLQTQAKLVLEENKLLL------EQLEIQQRKAKDSHQER 458
Query: 303 LSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASS--S 360
L ++K +E + + E ++L ++ + + +++H +A
Sbjct: 459 LQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAK----CQELKTHSDGKIAVEVHK 514
Query: 361 ALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR 420
++ + + K+ E+ R + +L E+ T LQ Q LE L + LE ELE A+
Sbjct: 515 SIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQ 574
Query: 421 EGEEERREREEVLREEIQ 438
+ + +++ EVL+++++
Sbjct: 575 KINRKSQKKIEVLKKQVE 592
Score = 44.7 bits (104), Expect = 3e-04
Identities = 73/348 (20%), Positives = 148/348 (42%), Gaps = 48/348 (13%)
Query: 123 VYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFV 182
V +E E+++ E L KS V + ++T+ + + EEN Q+E
Sbjct: 401 VVKENEELHQE---LNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQ--------- 448
Query: 183 RTLAEKRPDASWVINGLKQRILKLEQQC--KEKDGTISKLQTDMKTTNLEEMR------I 234
R + + ++ L ++++ LE + +EK+ ++ Q ++ +E++ I
Sbjct: 449 RKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKI 508
Query: 235 AMETYYEEVHRLQTLLASSETTGK---KPLGEKKTGAKRQKKMGSALLSLSRSVQELTEE 291
A+E + V+ L++ L E + + L EK T + QKK SL LTE+
Sbjct: 509 AVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKK------SLLLEKNSLTEQ 562
Query: 292 NQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSH 351
N++L+ +L+R + K+Q +E K ++ + + E ++ AE +
Sbjct: 563 NKALEAELERAQKIN---RKSQKKIEVLKKQV-EKAMGNEMSAHQYLANLVGLAENITQE 618
Query: 352 PPACLASSSALHRQPRGDRNKDHE------RLRGAVRDLKEERTALQEQLLQRDLEVKQL 405
+ + + L + G NK + +L V+ K++ + R LE ++
Sbjct: 619 RDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQED 678
Query: 406 LQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
K + +E R +VL+++ + L LQ+ +EM+ E
Sbjct: 679 FAGKT---------AQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGE 717
Score = 44.3 bits (103), Expect = 4e-04
Identities = 65/298 (21%), Positives = 126/298 (42%), Gaps = 25/298 (8%)
Query: 185 LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVH 244
L EK P + + +QR ++ +EK + + D+ N + + + + T + +
Sbjct: 214 LCEKPPPSPDITGRARQRYTEIT---REKFEALKEENMDLNNMN-QSLTLELNTMKQAMK 269
Query: 245 RLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRV-- 302
LQ L E +K +K A Q+ LL L + QEL +EN LK + R+
Sbjct: 270 ELQLKLKGMEKEKRKLKEAEK--ASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNV 327
Query: 303 -LSTSPT----ISKTQGY-VEW--SKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPA 354
LS T +SK + +E SK + +++++ ++ + + E + A
Sbjct: 328 ELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKE--KDELNA 385
Query: 355 CLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEK 414
L + R + K++E L ++L + E+ Q + K +L+ L +
Sbjct: 386 TLKEEMRMFRMRVQEVVKENEELH---QELNKSSAVTSEEWRQLQTQAKLVLEENKLLLE 442
Query: 415 ELEC----AREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
+LE A++ +ER + L +++ L +K ++ E +E + K QEL
Sbjct: 443 QLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQEL 500
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 62.0 bits (149), Expect = 2e-09
Identities = 86/359 (23%), Positives = 147/359 (40%), Gaps = 74/359 (20%)
Query: 133 EIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDA 192
EI ++K ++S + K+ RL EE +++ I+ L +T +RP
Sbjct: 171 EIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDL----------KTELLQRPGI 220
Query: 193 SWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLAS 252
V +LK E + ++QT M LE R + E +E +LQ+ AS
Sbjct: 221 EDVA------VLKKE---------LVQVQTLMDNMTLERERES-EKLKDECKKLQSQYAS 264
Query: 253 SETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKT 312
SE T + E G + L L SV ELT++NQ+L E+L + K
Sbjct: 265 SEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL---------LKKE 315
Query: 313 QGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPAC-------LASSSALHR- 364
Q Y +LE+K + SK + + C AS ++LHR
Sbjct: 316 QDY------------TKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRI 363
Query: 365 ----QPRGDRNK-----------DHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAK 409
+G+ + ++ L+ + L+++R ++ LQ E+ QL
Sbjct: 364 HVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL 423
Query: 410 ADLEKEL-ECAREGEEERREREEVL---REEIQTLTSKLQELQEMKKEEKEDCPEVPHK 464
+ E++L E +E+R+ E L +++ L KL L+E KE+ + E+ H+
Sbjct: 424 LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482
Score = 59.7 bits (143), Expect = 9e-09
Identities = 75/344 (21%), Positives = 150/344 (43%), Gaps = 41/344 (11%)
Query: 161 ENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQ---RILKLEQQCKEKDGTI 217
+N+ +D+Q E ++ L +K+ S + + LK+ + L LEQ+ +E +G I
Sbjct: 673 QNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI 732
Query: 218 SKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQ--KKMG 275
KL+ D + + + + L ++E + + + ++ + R +K
Sbjct: 733 KKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKS 792
Query: 276 SALLSLSRSVQELTEENQSLKEDLDRVLSTSP------------TISKTQGYVEWSKPRL 323
AL S+ + + + EE Q LK+D + + + T+++ Q V+ K L
Sbjct: 793 EALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK-VKMEKEAL 851
Query: 324 LRRIVELEKKLS-VMESSKSHAAEPVRSHPPA----------CLASSSALHRQPRG---- 368
+ + ++ KLS V +S K+ +E + + C L Q
Sbjct: 852 MTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE 911
Query: 369 --DRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEER 426
+ K E+ + A LK E ++QEQL+Q +KQ + + L+ + ++ E++
Sbjct: 912 QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK 971
Query: 427 REREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPA 470
+++ E L+ E+ K+ LQ+ + E K ++ AQEL A
Sbjct: 972 KKQIEALQGEL-----KIAVLQKTELENKLQ-QQLTQAAQELAA 1009
Score = 55.5 bits (132), Expect = 2e-07
Identities = 79/366 (21%), Positives = 148/366 (40%), Gaps = 43/366 (11%)
Query: 126 EKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGT--DFVR 183
E E Y + K L Q+ + + +L+ + K + E+ L + G + +
Sbjct: 383 EVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQ 442
Query: 184 TLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEV 243
+EK D + L+ ++ +LE+Q KEK ++LQ + T + ++E
Sbjct: 443 LSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ---------HQEQ 493
Query: 244 HRLQTLLASSETTGKKPLGE--KKTGAKRQKKMG-SALLSLSRSVQELTEENQSLKEDLD 300
LQ + + L + ++ G K QK ALL S+ L E+ +EDL
Sbjct: 494 QALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKE---REDLY 550
Query: 301 RVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSS 360
+ + ++ L ++ +L +KL S A E +
Sbjct: 551 AKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQ-----VQEQ 605
Query: 361 ALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQ----LLQA-------K 409
H + DR L +V +L + +E++ Q D+++K LL A +
Sbjct: 606 KAHLRAAQDRVLS---LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQR 662
Query: 410 ADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQE-------MKKEEKEDCPEVP 462
ADL+ L+ A+ +++++ + ++ +T+KLQ+ QE KE KE +
Sbjct: 663 ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLE 722
Query: 463 HKAQEL 468
K +EL
Sbjct: 723 QKTEEL 728
Score = 48.1 bits (113), Expect = 3e-05
Identities = 78/385 (20%), Positives = 161/385 (41%), Gaps = 56/385 (14%)
Query: 126 EKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEE------------------------ 161
+ E+ E ELKKSL +K ++ +L ++E+
Sbjct: 904 QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE 963
Query: 162 ----NSRKDRQIEQL-----LDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKE 212
+ +K +QIE L + + T+ L ++ A+ + K++I L+ ++
Sbjct: 964 LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEK 1023
Query: 213 KDGTISKLQTDM--KTTNLEEMRIAMETYYEEVHRLQTLLASSET---TGKKPLGEKKTG 267
T +LQ+D + + L R +++ E++ Q L S+ K + E KT
Sbjct: 1024 SQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKT- 1082
Query: 268 AKRQKKMGSALLSLSRSVQELTEENQSLKE-DLDRVLSTSPTISKTQ--GYVEWSKPRLL 324
AK + SA + Q+L E ++L++ ++ L +++ +E K R
Sbjct: 1083 AKATLEQDSA-----KKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQE 1137
Query: 325 RRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDL 384
+ I +L ++L KSH E ++ L + L Q + + + L+ AV
Sbjct: 1138 KEITKLNEEL------KSHKLESIKE--ITNLKDAKQLLIQQKLELQGKADSLKAAVEQE 1189
Query: 385 KEERTALQEQLLQRDLEV-KQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSK 443
K + L++Q+ + + E+ K+ ++ +A L E++ G ++ E E L +I L
Sbjct: 1190 KRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNEN 1249
Query: 444 LQELQEMKKEEKEDCPEVPHKAQEL 468
L +++ + + E+ + +L
Sbjct: 1250 LGTVKKEWQSSQRRVSELEKQTDDL 1274
Score = 45.4 bits (106), Expect = 2e-04
Identities = 67/320 (20%), Positives = 140/320 (43%), Gaps = 48/320 (15%)
Query: 200 KQRILKLEQQCKEKDGTISKLQTDMKTTNLE--EMRIAMETYYEEVHRLQTLLASSETTG 257
K IL LE+ CKE +LQ M+ T E E++ ++E E H+L+ L S +
Sbjct: 884 KAAILDLEKTCKELK---HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL 940
Query: 258 KKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLD-RVLSTSPTISKTQGYV 316
+ K K ++++ + L +S ++ ++ ++L+ +L VL + +K Q +
Sbjct: 941 IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000
Query: 317 EWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSAL-------------- 362
+ L ++K+SV++++ + E + S L
Sbjct: 1001 TQAAQELAAE----KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKL 1056
Query: 363 ---------HRQPRGDRNKDHERLRGAV-----------RDLKEERTALQEQLLQRDLEV 402
+R G++NK + L+ A + L+E ALQ+ ++ L+
Sbjct: 1057 SLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKE 1116
Query: 403 KQLLQAKADLE--KELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPE 460
K+L+ K+ L +E++C R+ +E + EE+ +++++ ++ L++ K+ + E
Sbjct: 1117 KELVNEKSKLAEIEEIKC-RQEKEITKLNEELKSHKLESI-KEITNLKDAKQLLIQQKLE 1174
Query: 461 VPHKAQELPAPTPSSRHCEQ 480
+ KA L A + +Q
Sbjct: 1175 LQGKADSLKAAVEQEKRNQQ 1194
Score = 36.2 bits (82), Expect = 0.10
Identities = 44/177 (24%), Positives = 83/177 (46%), Gaps = 41/177 (23%)
Query: 123 VYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFV 182
V +E+E++ E IE + LH S++ +++ EE ++ QI L + + GT
Sbjct: 1200 VKKEEEELKKEFIEKEAKLH---SEIKEKEVGMKKHEENEAKLTMQITAL-NENLGT--- 1252
Query: 183 RTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE- 241
+K +S ++R+ +LE+Q + G I+ L+ ++ N +E R +E +
Sbjct: 1253 ---VKKEWQSS------QRRVSELEKQTDDLRGEIAVLEATVQN-NQDERRALLERCLKG 1302
Query: 242 --EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLK 296
E+ +LQT + + Q+K+ + + +VQEL ENQSL+
Sbjct: 1303 EGEIEKLQTKVL-----------------ELQRKLDNT----TAAVQELGRENQSLQ 1338
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 61.6 bits (148), Expect = 2e-09
Identities = 106/523 (20%), Positives = 201/523 (38%), Gaps = 86/523 (16%)
Query: 22 PPPTSPKSPYLSKPRKVASWRSLRTAGSMPLGGRASLTPQKLWLGTAKPGSLTQALNSPL 81
P P P P+L + + L T +P S ++ L AK L
Sbjct: 5 PQPHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPMMSKETRQSKLAEAK---------EQL 55
Query: 82 TWEHAWTGVPGGTPDCLTDTFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSL 141
T H T GT T ++ + ++G ++ + E L++ L
Sbjct: 56 TDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQKASHQHQEA--LRREL 113
Query: 142 HVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVING-LK 200
Q + ++ + L+ ++QL +R D + L + SW G L+
Sbjct: 114 EAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEAR--DLISRLHD-----SWKFAGELE 166
Query: 201 QRILKLEQQCKEKDGTISKLQTDMKTTNLEEMR--IAMETYYEEVHRLQT---LLASSET 255
Q + + Q K+ D I +L + +LE R I E E+ +LQ L+ S ++
Sbjct: 167 QALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKS 226
Query: 256 TGKKPLGEKKTGAKRQK-------------KMGSALLSLSRSVQELTEENQ--------- 293
+ + E K +R K +G L S+S +Q EEN+
Sbjct: 227 EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQ 286
Query: 294 ---------SLKEDLDRVLSTSPTIS------KTQGYVEWSKPRLLRRIVEL----EKKL 334
++E +++ I + Q + W K +RR E+ E+K+
Sbjct: 287 EEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI 346
Query: 335 SVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRN----KDHERLRGAVRDLKEERTA 390
+E K H E +R ++ R ++ + E++R ++E+
Sbjct: 347 RELEE-KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEM 405
Query: 391 LQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEM 450
+QEQ + + +++ + + +++++ E R EE+ RE+E+ +RE+ K++E +EM
Sbjct: 406 MQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQ----EEKIREQEEM 461
Query: 451 KKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPR 493
+E++E E + CEQ+ EE + R
Sbjct: 462 MQEQEEKMGE------------QEGKMCEQEAKMQEQEEKMRR 492
Score = 56.6 bits (135), Expect = 7e-08
Identities = 69/379 (18%), Positives = 158/379 (41%), Gaps = 32/379 (8%)
Query: 151 MRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQC 210
++ KL+ +E E S +++L + + + +A + L+ KL+ Q
Sbjct: 214 LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQV 273
Query: 211 KEKD--GTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGA 268
+E + +++ Q + E+++ E E+ +++ ++ + EK+
Sbjct: 274 EENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQ-EEMMWEKEEKM 332
Query: 269 KRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVE----WSKPRLL 324
+RQ++M R ++E E + ++E ++ + + + W + +
Sbjct: 333 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI 392
Query: 325 R----RIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGA 380
R +I E E+ + E E + + RQ R ++ +++R
Sbjct: 393 REQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQE-KKIREQ 451
Query: 381 VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTL 440
++E+ +QEQ + + ++ + +A ++++ E R EE+ RE+E+ +RE+
Sbjct: 452 EEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQ---- 507
Query: 441 TSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSD 500
K++E +EM +E++E E K CEQ+ EE + R +
Sbjct: 508 EEKIREQEEMMQEQEEKMWEQEEKM------------CEQEEKMQEQEEKMRRQ----EE 551
Query: 501 GRRDAAARVLQAQWKVYKH 519
R+ R+ Q + K+ +H
Sbjct: 552 KMREQEVRLRQQEEKMQEH 570
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 61.2 bits (147), Expect = 3e-09
Identities = 88/444 (19%), Positives = 182/444 (40%), Gaps = 36/444 (8%)
Query: 110 RRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQI 169
++S H + +ED + +I++ L Q D++ + ++L + R R++
Sbjct: 1000 KKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKL 1059
Query: 170 EQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQ-QCKEKDGTISKLQTDMKTTN 228
E L S+ ++ + D + LK++ +L Q Q K D + LQ K
Sbjct: 1060 EGDLKMSQ-----ESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKK--- 1111
Query: 229 LEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQEL 288
++E++ +E EE+ TL A E E + ++R ++ A + ++
Sbjct: 1112 IKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKR 1171
Query: 289 TEENQSLKEDLDRVL----STSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHA 344
E Q ++ DL+ +T+ T+ K Q + + +++KL +S
Sbjct: 1172 EAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKME 1231
Query: 345 AEPVRSHPPACLASSSALHRQPRGDRN-------KDHERLRGAVRDLKEERTALQEQ--- 394
+ + S+ A S S + R R + KD ++ + + DL ++ LQ Q
Sbjct: 1232 IDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQ-LIHDLNMQKARLQTQNGE 1290
Query: 395 ----LLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEM 450
+ +++ + QL ++K L ++LE + EE + + + +Q+ L+E
Sbjct: 1291 LSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQ 1350
Query: 451 KKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVL 510
+EE+E KA+ A + ++ Q W + + R + ++ A R+
Sbjct: 1351 YEEEQE------AKAELQRALSKANSEVAQ-WRTKYETDAIQRTEE-LEEAKKKLAQRLQ 1402
Query: 511 QAQWKVYKHKKKKAVLDEAAVVLQ 534
+A+ K A L++ LQ
Sbjct: 1403 EAEENTETANSKCASLEKTKQRLQ 1426
Score = 48.9 bits (115), Expect = 2e-05
Identities = 65/299 (21%), Positives = 123/299 (41%), Gaps = 48/299 (16%)
Query: 200 KQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKK 259
K+ + + E + KE + + L + L+ ++ E + R + L+ S K
Sbjct: 864 KEELARSEARRKELEEKMVSLLQEKNDLQLQ-VQSETENLMDAEERCEGLIKSKILLEAK 922
Query: 260 PLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWS 319
+ E + +++M S L++ R++++ + SLK D+D + T + K + E
Sbjct: 923 -VKELTERLEEEEEMNSELVAKKRNLED---KCSSLKRDIDDLELTLTKVEKEKHATENK 978
Query: 320 KPRLLRRIVELEKKLSVMESSKSHAAEPVR-----------------------SHPPACL 356
L + LE+ +S + K E + L
Sbjct: 979 VKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDL 1038
Query: 357 ASSSALHRQPRGDRNKDHERLRG-------AVRDLKEERTALQEQLLQRDLEVKQLLQAK 409
S ++ R D + +L G ++ DL+ ++ ++E+L +++ E+ Q LQAK
Sbjct: 1039 EGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQ-LQAK 1097
Query: 410 ADLE-----------KELECAREGEEERREREEVLREEIQTLTSKL-QELQEMKKEEKE 456
D E KEL+ E EE E E LR +I+ S L +EL+E+ + +E
Sbjct: 1098 IDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEE 1156
Score = 47.4 bits (111), Expect = 4e-05
Identities = 73/404 (18%), Positives = 157/404 (38%), Gaps = 86/404 (21%)
Query: 128 EDMYDEIIELKKSLHVQKSDVDLMRTK-----LRRLEEENSRKDRQIEQLLDPSRGTDFV 182
E+ + EL+++L S+V RTK ++R EE K + ++L + T+
Sbjct: 1352 EEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETA 1411
Query: 183 RTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEE 242
+ + LE+ + G + L D LE A T ++
Sbjct: 1412 NS-----------------KCASLEKTKQRLQGEVEDLMRD-----LERSHTACATLDKK 1449
Query: 243 VHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTE-------ENQSL 295
+LA + + E + K + + + L + + +E+ + EN++L
Sbjct: 1450 QRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNL 1509
Query: 296 KEDL----DRVLSTSPTIS---KTQGYVEWS----------------------------- 319
+E++ +++ T + KT+ VE
Sbjct: 1510 QEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLEL 1569
Query: 320 ---KPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSS---ALHRQPRGDRNKD 373
K L R+++E ++++ ++ + AAE ++S A + S + L ++ GD N+
Sbjct: 1570 SQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEM 1629
Query: 374 HERLRGAVRDLKEERTAL---QEQLLQRDLEVKQLLQAKADLEKELECAREGEEERRERE 430
+L + R + E + L Q QL L + L++ DL+++L R
Sbjct: 1630 EIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIV-------ERRN 1682
Query: 431 EVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPS 474
+L EE++ + L++ + ++ +++ + + Q L + S
Sbjct: 1683 GLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTS 1726
Score = 47.0 bits (110), Expect = 6e-05
Identities = 73/389 (18%), Positives = 168/389 (43%), Gaps = 47/389 (12%)
Query: 109 LRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQ 168
L R H + +++ + + E K+ L +++++ + + R L E +
Sbjct: 1432 LMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNA 1491
Query: 169 IEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGT---ISKLQTDMK 225
E+++D + TL + + I+ L ++I + + +E + T + + ++D++
Sbjct: 1492 YEEVVDQ------LETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQ 1545
Query: 226 TTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSV 285
LEE+ ++E ++ R+Q L+ ++ + + EK ++ K+ +SV
Sbjct: 1546 VA-LEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSV 1604
Query: 286 --QELTEENQSLK------EDLD-----------RVLSTSPTISKTQGYVEWSKPRL--- 323
E+ N +L+ DL+ ++ T + QG ++ S+ L
Sbjct: 1605 LDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDA 1664
Query: 324 LRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGA--V 381
LR +L+++L+++E E + AL + R R + E L + V
Sbjct: 1665 LRSNEDLKEQLAIVERRNGLLLEELEE-------MKVALEQTERTRRLSEQELLDASDRV 1717
Query: 382 RDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERRER---EEVLREEIQ 438
+ L + T+L ++ LE + Q +A++E ++ +R EE+ ++ ++ EE++
Sbjct: 1718 QLLHSQNTSLINT--KKKLEA-DIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELK 1774
Query: 439 TLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
L+ MKK ++ ++ H+ E
Sbjct: 1775 KEQDTSAHLERMKKNLEQTVKDLQHRLDE 1803
Score = 45.4 bits (106), Expect = 2e-04
Identities = 75/360 (20%), Positives = 147/360 (40%), Gaps = 50/360 (13%)
Query: 126 EKEDMYDEIIELKKSLHVQKSD----VDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF 181
E + D + +K+ L +KS+ +D M + + L + S +R + D
Sbjct: 1206 ELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSE--- 1262
Query: 182 VRTLAEKRPDASWVINGLKQRIL----KLEQQCKEKDGTISKLQTDMK--TTNLEEMRIA 235
++ E++ +N K R+ +L + +EK+ IS+L + T LEE++
Sbjct: 1263 IKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQ 1322
Query: 236 METYYEE----VHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSR-------- 283
ME + H LQ+ + ++ E++ A+ Q+ + A +++
Sbjct: 1323 MEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETD 1382
Query: 284 ---SVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESS 340
+EL E + L + L + T + +E +K RL + +L + L
Sbjct: 1383 AIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLE----- 1437
Query: 341 KSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDL 400
RSH AC + L ++ R + +K + + + + E A Q++
Sbjct: 1438 --------RSHT-AC----ATLDKKQR-NFDKVLAEWKQKLDESQAELEAAQKESRSLST 1483
Query: 401 EVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKK---EEKED 457
E+ ++ A ++ +LE R + +E L E+I LQE ++ KK +EK D
Sbjct: 1484 ELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSD 1543
Score = 36.6 bits (83), Expect = 0.078
Identities = 28/97 (28%), Positives = 49/97 (50%), Gaps = 7/97 (7%)
Query: 372 KDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREE 431
+D ER + + + R L+E+++ LLQ K DL+ +++ E + ER E
Sbjct: 858 EDFERTKEELARSEARRKELEEKMVS-------LLQEKNDLQLQVQSETENLMDAEERCE 910
Query: 432 VLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
L + L +K++EL E +EE+E E+ K + L
Sbjct: 911 GLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNL 947
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
Length = 1478
Score = 61.2 bits (147), Expect = 3e-09
Identities = 78/363 (21%), Positives = 159/363 (43%), Gaps = 36/363 (9%)
Query: 199 LKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE------EVHRLQTLLAS 252
L++R+ +L+++ +E +S+ Q + T E R A E E+ + + +
Sbjct: 249 LRERMQQLDRENQELRAAVSQ-QGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQA 307
Query: 253 SETTGKKPL----GEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRV---LST 305
++ T K+ G + A++++ +AL L +Q L +E ++ ++ LD+ L++
Sbjct: 308 TQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLAS 367
Query: 306 SP-----------TISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPA 354
P T S T+G E + + EL +KL +E ++ E R +
Sbjct: 368 FPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQ--S 425
Query: 355 CLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEK 414
Q + D ERL + L+EE + ++ Q +++LL + E+
Sbjct: 426 AQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEE 485
Query: 415 ELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPS 474
EL R +++++E +E+L +E+++LT +LQ L+ + + ++ + ++L
Sbjct: 486 ELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQL---IQD 542
Query: 475 SRHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARV---LQAQWKVYKHKKK---KAVLDE 528
H Q G P P P + + +A V LQ W + +++ +A LD+
Sbjct: 543 KDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDD 602
Query: 529 AAV 531
V
Sbjct: 603 TKV 605
Score = 43.9 bits (102), Expect = 5e-04
Identities = 58/300 (19%), Positives = 134/300 (44%), Gaps = 34/300 (11%)
Query: 159 EEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTIS 218
++ ++ D + Q PS ++ L EK + L++ K+E+ +++ +
Sbjct: 377 QKADTASDTKGRQEPIPSDAAQEMQELGEK-------LQALERERTKVEEVNRQQSAQLE 429
Query: 219 KLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSAL 278
+L +++ E+ R ++E +E+ LQ E +GK ++ +R +++ +
Sbjct: 430 QLVKELQLK--EDARASLERLVKEMAPLQ-----EELSGKGQEADQLW--RRLQELLAHT 480
Query: 279 LSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVME 338
S + EL E + +E+ + + ++++ ++E ++ + + +LE++ +
Sbjct: 481 SSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLI 540
Query: 339 SSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDL----KEERTALQEQ 394
K H ++ V LA G++N+ + ++++ +EE+ LQE
Sbjct: 541 QDKDHLSQQVGMLER--LAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEA 598
Query: 395 LL-----QRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQE 449
L Q + ++L QA +LEKEL + R ++L ++Q L + Q LQ+
Sbjct: 599 QLDDTKVQEGSQEEELRQANRELEKEL-------QNVVGRNQLLEGKLQALQADYQALQQ 651
Score = 33.1 bits (74), Expect = 0.87
Identities = 62/305 (20%), Positives = 116/305 (38%), Gaps = 60/305 (19%)
Query: 199 LKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGK 258
+K ++ + E + K+G +L+ ++ E+ + E + E+ L+ S+ +
Sbjct: 691 MKAQMAEKEAILQSKEGECQQLREEV-----EQCQQLAEARHRELRALE-----SQCQQQ 740
Query: 259 KPLGEKKTGAKRQKKMG----------SALLSLSRS--------VQELTEENQSLKEDLD 300
L E T K Q+ +G +A L+LS++ VQ L + L+ +
Sbjct: 741 TQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMR 800
Query: 301 RVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESS--KSHAAEPVRSHPPACLAS 358
L + E +LR L ++L + ++H E ++ C
Sbjct: 801 AALDDQDKVQSQLSMAE----AVLREHKTLVQQLKEQNEALNRAHVQELLQ-----CSER 851
Query: 359 SSALHRQPRGDRNKDHERLRGAVRDLKE----------ERTALQEQLLQRD-------LE 401
AL + + + E LR +L + E LQEQL + + ++
Sbjct: 852 EGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQ 911
Query: 402 VKQLLQAKADLEKELECA----REGEEERREREEVLREEIQTLTSKLQELQEMKKEEKED 457
V L K +E+ L CA ++ +E E L ++ L + + LQE K K
Sbjct: 912 VCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAA 971
Query: 458 CPEVP 462
+P
Sbjct: 972 AGSLP 976
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 60.8 bits (146), Expect = 4e-09
Identities = 77/360 (21%), Positives = 159/360 (44%), Gaps = 43/360 (11%)
Query: 126 EKEDMYDEIIELKKSLHVQ----KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF 181
++E+M E+ K+ L + K D+D + L ++E+E + +++ L + G D
Sbjct: 928 DEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDE 987
Query: 182 V--------RTLAEKRPDA-------SWVINGLKQRILKLEQQCKEKDGTIS---KLQTD 223
+ + L E A +N L + +KLEQQ + +G++ K++ D
Sbjct: 988 IIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMD 1047
Query: 224 MKTTNLE---EMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAK--RQKKMGSAL 278
++ + ++++ E+ + + Q L E KK A+ ++ +GS
Sbjct: 1048 LERAKRKLEGDLKLTQESIMDLENDKQQL---DERLKKKDFELNALNARIEDEQALGS-- 1102
Query: 279 LSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSV-M 337
L + ++EL + L+E+L+ + + K + + + R+ E SV +
Sbjct: 1103 -QLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQI 1161
Query: 338 ESSKSHAAE---PVRSHPPACL---ASSSAL---HRQPRGDRNKDHERLRGAVRDLKEER 388
E +K AE R A L A+++AL H + + + L+ + L++E+
Sbjct: 1162 EMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEK 1221
Query: 389 TALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQ 448
+ + +L ++Q+++AKA+LEK + E R + E + + LTS+ +LQ
Sbjct: 1222 SEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ 1281
Score = 48.5 bits (114), Expect = 2e-05
Identities = 76/369 (20%), Positives = 149/369 (40%), Gaps = 34/369 (9%)
Query: 110 RRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVD--LMRTKLRRLEEENSRKDR 167
+++ H + +ED + + + K L Q D++ L + K R++ E +++
Sbjct: 996 KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKL 1055
Query: 168 QIEQLLDPSRGTDFV---RTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDM 224
+ + L D + L E+ + +N L RI +++ S+LQ +
Sbjct: 1056 EGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARI-------EDEQALGSQLQKKL 1108
Query: 225 KTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRS 284
K E++ +E EE+ +T A E E + ++R ++ G A
Sbjct: 1109 K-----ELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEM 1163
Query: 285 VQELTEENQSLKEDLDRV-LSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSH 343
++ E Q ++ DL+ L T + + S L +I L++ +E KS
Sbjct: 1164 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1223
Query: 344 ---AAEPVRSHPPACLASSSALHRQPRG--DRNKDH----ERLRGAVRDLKEERTALQ-- 392
+ V S+ + + + L + R D+ +H E + +V DL +R LQ
Sbjct: 1224 FKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283
Query: 393 -----EQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQEL 447
QL +++ + QL + K ++LE + EE + + L +Q+ L
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 448 QEMKKEEKE 456
+E +EE E
Sbjct: 1344 REQYEEETE 1352
Score = 46.2 bits (108), Expect = 1e-04
Identities = 55/325 (16%), Positives = 139/325 (42%), Gaps = 25/325 (7%)
Query: 132 DEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPD 191
+E + +KK + +++++ + R+ E ++ + ++ LL ++ + D
Sbjct: 1609 NEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ---------IQLDD 1659
Query: 192 ASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLA 251
A + LK+ I +E++ + +L+ ++ T ++A + E R+Q L +
Sbjct: 1660 AVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTE-RSRKLAEQELIETSERVQLLHS 1718
Query: 252 SSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISK 311
+ + ++KKM + L L V+E +E ++ +E + ++ + +++
Sbjct: 1719 QNTSL-----------INQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAE 1767
Query: 312 TQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRN 371
+ + L R +E+ + ++ A + L A R+ +
Sbjct: 1768 ELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELE 1827
Query: 372 KDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREE 431
+ +R +V+ +++ ++E Q + + K LL+ + DL +L+ + + + E E
Sbjct: 1828 AEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQ-DLVDKLQLKVKAYKRQAEEAE 1886
Query: 432 VLREEIQTLTSKLQELQEMKKEEKE 456
E+ T SK +++Q E +E
Sbjct: 1887 ---EQANTNLSKFRKVQHELDEAEE 1908
Score = 40.0 bits (92), Expect = 0.007
Identities = 68/363 (18%), Positives = 134/363 (36%), Gaps = 55/363 (15%)
Query: 125 REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
+E + E+ +LK + ++ + + + L+EE S + + L S T +
Sbjct: 1472 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS----DLTEQLGSSGKT--IHE 1525
Query: 185 LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLE----------EMRI 234
L + R L+ + + E + ++G I + Q + E EM
Sbjct: 1526 LEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 1585
Query: 235 AMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQS 294
A + V LQT L + + + L KK +M L +R E ++ +S
Sbjct: 1586 AKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKS 1645
Query: 295 LKE-------DLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEP 347
L+ LD + + + + VE L + EL + E S+
Sbjct: 1646 LQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRK----- 1700
Query: 348 VRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQ 407
LA + R V+ L + T+L Q + D ++ QL
Sbjct: 1701 --------LAEQELIETSER-------------VQLLHSQNTSLINQKKKMDADLSQL-- 1737
Query: 408 AKADLEKELECAREGEEERRER---EEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHK 464
+ ++E+ ++ R EE+ ++ ++ EE++ L+ MKK ++ ++ H+
Sbjct: 1738 -QTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHR 1796
Query: 465 AQE 467
E
Sbjct: 1797 LDE 1799
Score = 39.7 bits (91), Expect = 0.009
Identities = 29/93 (31%), Positives = 57/93 (61%), Gaps = 9/93 (9%)
Query: 384 LKEERTALQEQL-----LQRDLEVKQ--LLQAKADLEKELECAREGEEERRER-EEVLRE 435
+KEE T L+E L +++LE K LLQ K DL+ +++ ++ + ER +++++
Sbjct: 852 MKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKN 911
Query: 436 EIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
+IQ L +K++E+ E ++E+E E+ K ++L
Sbjct: 912 KIQ-LEAKVKEMNERLEDEEEMNAELTAKKRKL 943
Score = 37.0 bits (84), Expect = 0.060
Identities = 76/407 (18%), Positives = 163/407 (40%), Gaps = 64/407 (15%)
Query: 103 RVKRPHLRRSASNGHVP-----GTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRR 157
R+K+ +A N + G+ + ++ +++ I EL++ L +++ R K+ +
Sbjct: 1079 RLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERT----ARAKVEK 1134
Query: 158 LEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWV---------------------- 195
L + SR+ +I + L+ + G V+ K+ +A +
Sbjct: 1135 LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK 1194
Query: 196 ---------------INGLKQRILKLEQQCK-EKDGTISKLQTDMKT-TNLEEMRIAMET 238
+ +KQ++ K + + K E D S ++ +K NLE+M +E
Sbjct: 1195 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED 1254
Query: 239 YYEEVHRL---QTLLASSETTGKKPLGEKKTGA-KRQKKMGSALLS-LSRSVQELTEENQ 293
E HR +T + ++ T ++ + + G RQ AL+S L+R T++ +
Sbjct: 1255 QMNE-HRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLE 1313
Query: 294 SLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLS-----VMESSKSHAAEPV 348
LK L+ + ++ LLR E E + V+ + S A+
Sbjct: 1314 DLKRQLEEEVKAKNALAHALQSARHDCD-LLREQYEEETEAKAELQRVLSKANSEVAQWR 1372
Query: 349 RSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQA 408
+ + + L + + E AV + + ++L++ + E++ L+
Sbjct: 1373 TKYETDAIQRTEELEEAKKKLAQRLQEA-EEAVEAVNAKCSSLEKTKHRLQNEIEDLM-- 1429
Query: 409 KADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEK 455
D+E+ A ++++R +++L E Q EL+ +KE +
Sbjct: 1430 -VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEAR 1475
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 60.8 bits (146), Expect = 4e-09
Identities = 96/414 (23%), Positives = 167/414 (40%), Gaps = 65/414 (15%)
Query: 151 MRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQC 210
+ +L +LEEEN ++E AEKR +A W N LE Q
Sbjct: 615 LNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKN------THLEAQL 668
Query: 211 KEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKR 270
++ + ++LQ D++ E+ EE+ + + + L + AKR
Sbjct: 669 QKAEEAGAELQADLRDIQEEK---------EEIQKKLSESRHQQEAATTQLEQLHQEAKR 719
Query: 271 QKKMGSALLSLSRSVQE---LTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRI 327
Q+++ L+R+VQE L E +L+ L V +++ + +K L +
Sbjct: 720 QEEV------LARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSL 773
Query: 328 VELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLK-- 385
E +++ SV+E +K +++ A E ++G VR LK
Sbjct: 774 FEAQQQNSVIEVTKGQLEVQIQTVTQA-------------------KEVIQGEVRCLKLE 814
Query: 386 ---------EERTALQEQLLQRDLEVKQLL-QAKADLEKELECAREG-EEERREREEVLR 434
+ER A QL Q + E K L Q KA EKE+ RE E+ER ++ L
Sbjct: 815 LDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELA 874
Query: 435 EEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRP 494
+ +++L + EL+ KE++ + + + +E S+ C+ + L
Sbjct: 875 KALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESAL-CQMQLETEKERVSLLET 933
Query: 495 RSPCSDGRRDAAARV--LQAQWKVYKHKKKKAV------LDEAAVVLQAAFRGH 540
DA+ ++ L+ KV K K+++ L EA L+ A R H
Sbjct: 934 LLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQH 987
Score = 57.8 bits (138), Expect = 3e-08
Identities = 82/404 (20%), Positives = 165/404 (40%), Gaps = 66/404 (16%)
Query: 105 KRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSR 164
K HL G + + D+ +E E++K L + + T+L +L +E R
Sbjct: 660 KNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKR 719
Query: 165 KDR------QIEQLLDPSRGTDFVRTLAEKRP--DASWVINGL-------KQRILKLEQQ 209
++ Q ++ L + VR A +R D + + GL + + + +QQ
Sbjct: 720 QEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQ 779
Query: 210 CKEKDGTISKLQTDMKT-TNLEE--------MRIAMETYYEEVHRLQTL----LASSETT 256
+ T +L+ ++T T +E +++ ++T + + + LA +E
Sbjct: 780 NSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQE 839
Query: 257 GKKPLGEKKTGAKR----------------QKKMGSALLSLSRSVQELTEENQSLKEDLD 300
GK L ++K ++ Q+++ AL SL R EL + + +++
Sbjct: 840 GKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEME 899
Query: 301 RVLS------TSPTISKTQGYVEWSKPR--LLRRIVELEKKLSVMESSKSHAAEPVRSHP 352
+ + T + Q +E K R LL +++ +K+L+ + ++
Sbjct: 900 AIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQK 959
Query: 353 PACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADL 412
++ L Q L+ A R+LKE ++ L E LLQ K DL
Sbjct: 960 LKEQETTGILQTQ-----------LQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDL 1008
Query: 413 EKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKE 456
+K++E + + + + ++ +E+Q KL+E QE + +KE
Sbjct: 1009 QKQVEDLKSQLVAQDDSQRLVEQEVQ---EKLRETQEYNRIQKE 1049
Score = 57.4 bits (137), Expect = 4e-08
Identities = 98/466 (21%), Positives = 196/466 (42%), Gaps = 76/466 (16%)
Query: 125 REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
++ + ++ ++ E L ++ ++ +++ +L+ E+ K++ ++ LD ++ R
Sbjct: 1757 QQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQ-----RA 1811
Query: 185 LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVH 244
LA++ + + +Q+ E++ KEK + T L+E ++ + E+
Sbjct: 1812 LAQRDQELE-ALQQEQQQAQGQEERVKEKADALQGALEQAHMT-LKERHGELQDHKEQAR 1869
Query: 245 RLQTLLASSETTGK---KPLGEKKTGAKRQKKMGSALLSLSRSVQELTEEN--------- 292
RL+ LA + + LG+ + ++ Q+K ALL+L + E +E+
Sbjct: 1870 RLEEELAVEGRRVQALEEVLGDLRAESREQEK---ALLALQQQCAEQAQEHEVETRALQD 1926
Query: 293 -----QSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVE-LEKKLSVMESSKSHAAE 346
Q++ ++ D+ L S++ + E + + E L K + ++ + H E
Sbjct: 1927 SWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLE 1986
Query: 347 P-------------VRSHPPACLASSSALHRQPRGDRNK----------DHERLRGAVRD 383
+++ AC A S L R + D ++L+ A+
Sbjct: 1987 QAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQ 2046
Query: 384 LKEERTALQE--QLLQRDLEVK---QLLQAKADLEKELECAREGEEERREREEVLREEIQ 438
EE QE QLL++ L + ++Q K +L +E E EEE R + +RE
Sbjct: 2047 RDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQERE-----EEEIRGLHQSVRELQL 2101
Query: 439 TLTSKLQELQEMKK-EEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSP 497
TL K QE+ E+++ +++ + +PH + P EQ DS E L R
Sbjct: 2102 TLAQKEQEILELRETQQRNNLEALPHSHKTSPME-------EQSLKLDSLEPRLQRELER 2154
Query: 498 CSDGRRDAAARVLQAQWK-------VYKHKKKKAVLDEAAVVLQAA 536
R AR ++ + K + + K + L E A+ LQA+
Sbjct: 2155 LQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQAS 2200
Score = 57.0 bits (136), Expect = 6e-08
Identities = 111/514 (21%), Positives = 213/514 (41%), Gaps = 44/514 (8%)
Query: 117 HVPGTPVYREKE--DMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLD 174
H+P RE++ ++I EL+K Q++ ++ +L LE+++ + Q Q+ D
Sbjct: 1491 HLPMAVQEREQKLTVQREQIRELEKDRETQRN---VLEHQLLELEKKDQMIESQRGQVQD 1547
Query: 175 PSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRI 234
+ + LA + + + ++ I +LE Q + + ++ L T +LEE
Sbjct: 1548 LKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHL-----TLDLEERSQ 1602
Query: 235 AMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSV-QELTEENQ 293
++ ++H L+ S T + L E+ K Q++ L + Q+L +Q
Sbjct: 1603 ELQAQSSQIHDLE----SHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQ 1658
Query: 294 SLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPP 353
L +R+ ++ +E ++ + E ++L+ AE +
Sbjct: 1659 ELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSK 1718
Query: 354 ACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQL--LQRDLEVKQLLQAKAD 411
A S + R D+ K+ E + + +L+E + L++QL L R + LL ++ +
Sbjct: 1719 AQRGSLEHMKLILR-DKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQRE 1777
Query: 412 -----LEKELECARE-GEEERREREEVLREEIQTLTSKLQELQEMKKEEKE---DCPEVP 462
L+++L+ ARE GE + + + L E + L + QEL+ +++E+++ V
Sbjct: 1778 QEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVK 1837
Query: 463 HKAQELPAP------TPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKV 516
KA L T RH E D E+ +GRR A + +
Sbjct: 1838 EKADALQGALEQAHMTLKERHGELQ---DHKEQARRLEEELAVEGRRVQALEEVLGDLRA 1894
Query: 517 YKHKKKKAVLDEAAVVLQAAFRGHLTRTKLLASKAHGSEPPSVPGLPDQSSPVPRVPSPI 576
+++KA+L A+ Q A + + A + + +V DQ R
Sbjct: 1895 ESREQEKALL---ALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALR----- 1946
Query: 577 AQATGSPVQEEAIVIIQSALRAHLARARHSATGK 610
A++ S QEEA AL+ L +A + GK
Sbjct: 1947 AESQSSRHQEEAARARAEALQEALGKAHAALQGK 1980
Score = 53.1 bits (126), Expect = 8e-07
Identities = 72/368 (19%), Positives = 158/368 (42%), Gaps = 40/368 (10%)
Query: 126 EKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTL 185
E E + +I EL+K +QK+ ++L+ L++ +E + QI++L + R++
Sbjct: 1436 EVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQEL-------EKCRSV 1488
Query: 186 AEKRPDASWVINGLKQRILKLEQQCK--EKDGTISK-------LQTDMKTTNLEEMRIAM 236
E P A + +Q++ +Q + EKD + L+ + K +E R +
Sbjct: 1489 LEHLPMA---VQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQV 1545
Query: 237 ETYYEEVHRLQTLLASSETTGKKPLGEKK-----TGAKRQKKMGSALLSLSRSVQELTEE 291
+ +++ L+ L E K ++K G + +++ AL L+ ++E ++E
Sbjct: 1546 QDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRV--ALTHLTLDLEERSQE 1603
Query: 292 NQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSH 351
Q+ + + S S +++ + +I EL+++ + + +
Sbjct: 1604 LQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQ 1663
Query: 352 PPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLE---------- 401
RQ + +D E+++ ++R+ E T Q QL+Q E
Sbjct: 1664 KERIQVLEDQRTRQTK-ILEEDLEQIKLSLRERGRELTT-QRQLMQERAEEGKGPSKAQR 1721
Query: 402 --VKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCP 459
++ + D EKE+EC +E E +E ++ L +++Q L K+ E + + +++
Sbjct: 1722 GSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIV 1781
Query: 460 EVPHKAQE 467
+ + QE
Sbjct: 1782 VLQQQLQE 1789
Score = 48.9 bits (115), Expect = 2e-05
Identities = 63/338 (18%), Positives = 133/338 (39%), Gaps = 43/338 (12%)
Query: 132 DEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPD 191
+++ + +L ++ +V+ R + + L+E+ K Q + L + +TLAE+ +
Sbjct: 1379 EDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENL--ALLTQTLAEREEE 1436
Query: 192 ASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLA 251
+ L+ +I +LE+Q + + + L D+K N E ++ E++ L+ +
Sbjct: 1437 ----VETLRGQIQELEKQREMQKAALELLSLDLKKRNQE-----VDLQQEQIQELEKCRS 1487
Query: 252 SSE-------------TTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKED 298
E T ++ + E + + Q+ + L ++ E + +D
Sbjct: 1488 VLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQD 1547
Query: 299 LDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLAS 358
L + L T ++ + I ELE + + +H + A
Sbjct: 1548 LKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQ 1607
Query: 359 SSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELEC 418
SS +H DL+ T L +L +RD EVK + +L+++ E
Sbjct: 1608 SSQIH-------------------DLESHSTVLARELQERDQEVKSQREQIEELQRQKEH 1648
Query: 419 AREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKE 456
+ E R + + +E IQ L + ++ +E+ E
Sbjct: 1649 LTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686
Score = 47.4 bits (111), Expect = 4e-05
Identities = 83/359 (23%), Positives = 149/359 (41%), Gaps = 61/359 (16%)
Query: 125 REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGT----- 179
+E + E+I+LK ++K+++ T+L L ++ +++ E+++ R T
Sbjct: 258 KEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILE 317
Query: 180 -----------DFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTN 228
R E++ VI + Q +++ + G + L+ D
Sbjct: 318 TNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSS--- 374
Query: 229 LEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMG--SALLSLSRSVQ 286
I + Y++ + TL+ S T ++ + + RQ+ G A+ L +
Sbjct: 375 -----IFSQFDYQDADKALTLVRSVLTRRRQAVQD-----LRQQLAGCQEAVNLLQQQHD 424
Query: 287 ELTEENQSLKEDLDRVLSTSPTIS----KTQGYVE-WSKPR--LLRRIVELEKKLSVMES 339
+ EE ++L++ L ++ T++ QG V+ SK R L + EL ++L V+E
Sbjct: 425 QWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLE- 483
Query: 340 SKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRD 399
A R + L SA +G + + E L AVR ER LQE L+
Sbjct: 484 --QEAWRLRRVNVELQLQGDSA-----QGQKEEQQEELHLAVR----ERERLQEMLM--G 530
Query: 400 LEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKL----QELQEMKKEE 454
LE KQ ++ EL RE E E+LR+E +T+ L Q + E+ E
Sbjct: 531 LEAKQ-----SESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSE 584
Score = 47.4 bits (111), Expect = 4e-05
Identities = 77/370 (20%), Positives = 147/370 (39%), Gaps = 50/370 (13%)
Query: 131 YDEIIELKKSLHVQ--KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEK 188
++ +EL S+ Q D D T +R + +R+ + ++ L G L ++
Sbjct: 365 HENSLELDSSIFSQFDYQDADKALTLVRSVL---TRRRQAVQDLRQQLAGCQEAVNLLQQ 421
Query: 189 RPDASWVING--LKQRILKLEQQCKEKDGTISKLQTDMKTTNLE---------EMRIAME 237
+ D W G L+QR+ KL + G LQ ++ + + E E+R +E
Sbjct: 422 QHD-QWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLE 480
Query: 238 TYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKE 297
+E RL+ + + G G+K+ ++Q+++ A+ R + L E
Sbjct: 481 VLEQEAWRLRRVNVELQLQGDSAQGQKE---EQQEELHLAVRERERLQEMLMGLEAKQSE 537
Query: 298 DLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLA 357
L +++ + + LE +L E ++ AA A L+
Sbjct: 538 SLSELITLREALESSH----------------LEGELLRQEQTEVTAALARAEQSIAELS 581
Query: 358 SSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLL-------QAKA 410
SS + D +L L ++ L +QLLQ + E + + QA+
Sbjct: 582 SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641
Query: 411 DLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPA 470
L+ +L E +R E L E+ L ++LQ+ +E E + D ++ + +E+
Sbjct: 642 ALQVDL-------AEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQK 694
Query: 471 PTPSSRHCEQ 480
SRH ++
Sbjct: 695 KLSESRHQQE 704
Score = 40.4 bits (93), Expect = 0.005
Identities = 66/304 (21%), Positives = 127/304 (41%), Gaps = 44/304 (14%)
Query: 195 VINGLKQRILKLEQQCKEKD-------GTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQ 247
++ L+ ++L+ C+E + G I + +++ NL+E+ + +E EE R +
Sbjct: 55 LVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLE---EEQQRCE 111
Query: 248 TLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSP 307
+L +E + L +K + +L V++LT + +++L R S
Sbjct: 112 SL---AEVNTQLRLHMEKADVVNK--------ALREDVEKLTVDWSRARDELMRKESQWQ 160
Query: 308 TISKT-QGYVEWSKPRLL---RRIVELEKKLSVMESSKSH-----AAEPVR---SHPPAC 355
+ +GY++ RLL R +V + M+S+ AE VR S C
Sbjct: 161 MEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCC 220
Query: 356 LASS-SALHRQPRGDRNKDHER------LRGAVRDLKEERTALQEQLLQR----DLEVKQ 404
L + A R+P G D L ++L++E ++L+Q DLE +
Sbjct: 221 LRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAE 280
Query: 405 LLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHK 464
L +L L +++ E+ + + LRE ++ L + EL E + + E
Sbjct: 281 LQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLS 340
Query: 465 AQEL 468
Q++
Sbjct: 341 LQQV 344
Score = 37.4 bits (85), Expect = 0.046
Identities = 65/369 (17%), Positives = 151/369 (40%), Gaps = 41/369 (11%)
Query: 126 EKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTL 185
E + + ++L+K + KS + R +E+E K R+ ++ + L
Sbjct: 997 ESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEY------NRIQKEL 1050
Query: 186 AEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIA--METYYEEV 243
++ + + +QR+L L++ + +S L+ DM+ E+ ++ ME +EV
Sbjct: 1051 EREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEV 1110
Query: 244 HRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVL 303
+ + E + L E + ++++ ++L + +L +S + L+ +
Sbjct: 1111 KEKEADFLAQEA---QLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALA 1167
Query: 304 STSPTISKTQGYVEWSK-----PRLLRRIVELEKKLSV----------MESSKSHAAEPV 348
+ ++ Q + + + L + E +LS +E ++ A
Sbjct: 1168 AEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLF 1227
Query: 349 RSHPPACLASS----SALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQ 404
+ P S+ SALH+ ++D + + L+++ L+E+L + E Q
Sbjct: 1228 KRGPLLTALSAEAVASALHKL-----HQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQ 1282
Query: 405 LLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQ------EMKKEEKEDC 458
+ DL+++L +E + + ++ L E+ L + LQ E+++ E +
Sbjct: 1283 VHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGE 1342
Query: 459 PEVPHKAQE 467
E+ A+E
Sbjct: 1343 RELLQAAKE 1351
Score = 34.3 bits (77), Expect = 0.39
Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 25/194 (12%)
Query: 280 SLSRSVQELTEENQSLKEDLDRVL-STSPTISKTQGY---VEWSKPRLLR-RIVELEKKL 334
SLSR+ QE Q + +D+ +V+ I++ G+ +E + + +K L
Sbjct: 329 SLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKAL 388
Query: 335 SVMES---SKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTAL 391
+++ S + A + +R C + + L +Q ++ + LR ++ L ER L
Sbjct: 389 TLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ-HDQWEEEGKALRQRLQKLTGERDTL 447
Query: 392 QEQLLQRDLEVKQLLQAKAD-LEKELECAREGEEERREREEVLREEIQTLTSKLQELQ-- 448
Q + LQ + D L KE E ++ EE R++ EVL +E L ELQ
Sbjct: 448 AGQTVD--------LQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQ 499
Query: 449 -----EMKKEEKED 457
K+E++E+
Sbjct: 500 GDSAQGQKEEQQEE 513
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 59.7 bits (143), Expect = 9e-09
Identities = 78/428 (18%), Positives = 176/428 (41%), Gaps = 52/428 (12%)
Query: 118 VPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR 177
+P + E + + E+ + L Q + +L ++ EE+ R++ +I++ +
Sbjct: 319 LPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEK-- 376
Query: 178 GTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAME 237
++ EK + I ++++ + E+ EK+ + + Q +M E+MR E
Sbjct: 377 ----IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR-QEEMMWEKEEKMRRQEE 431
Query: 238 TYYEEVHRLQTLLASSETTGKKPLGEKKTGA----KRQKKMGSALLSLSRSVQELTEENQ 293
+E+ +++ L K E+K + Q+K + R +++ E+ +
Sbjct: 432 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 491
Query: 294 SLKEDLDRVLSTSPTISKTQGYVE----------WSKPRLLR----------RIVELEKK 333
++E +++ I + + E W + +R +I E E+K
Sbjct: 492 KIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEK 551
Query: 334 LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
+ E E + + RQ R ++ E++R ++E+ QE
Sbjct: 552 IRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQE-EKIREQEEKIREQEEMTQE 610
Query: 394 QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
Q + + +++ + + ++++ E R EE+ RE+E+ +RE+ K++E +EM +E
Sbjct: 611 QEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQ----EEKIREQEEMMQE 666
Query: 454 EKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQ 513
++E E K CEQ+ EE + R + + R+ Q +
Sbjct: 667 QEEKMWEQEEKM------------CEQEEKMQEQEEKMRRQ----EEKMWEQEVRLRQQE 710
Query: 514 WKVYKHKK 521
K+ +H++
Sbjct: 711 EKMQEHQE 718
Score = 43.9 bits (102), Expect = 5e-04
Identities = 80/392 (20%), Positives = 153/392 (39%), Gaps = 48/392 (12%)
Query: 137 LKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVI 196
L++ L Q + ++ + L+ ++QL +R D + L + SW
Sbjct: 182 LRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEAR--DLISRLHD-----SWKF 234
Query: 197 NG-LKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMR--IAMETYYEEVHRLQTLLASS 253
G L+Q + + Q K+ D I +L + +LE R I E E+ +LQ L
Sbjct: 235 AGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLV 294
Query: 254 ETTGKKPLGEKKTGAKRQKKMGSALL---SLSRSVQELTEENQSLKEDLDRVLSTSPTIS 310
E+ K + KR+ + LL L L +E QS+ L + + +
Sbjct: 295 ESE-KSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN 353
Query: 311 KTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDR 370
+ E R +I E E+K+ E E +R
Sbjct: 354 RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR--------------------- 392
Query: 371 NKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERRERE 430
+ E++R +EE +E+ ++R E+ + + + + ++ E E EE+ RE E
Sbjct: 393 -EQEEKMRR-----QEEMMWEKEEKMRRQEEM--MWEKEEKMRRQEEMMWEKEEKIRELE 444
Query: 431 EVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEG 490
E + E+ K++E +E ++EE++ + + QE + EQ+ EE
Sbjct: 445 EKMHEQ-----EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEK 499
Query: 491 LPRPRSPCSDGRRDAAARVLQAQWKVYKHKKK 522
+ R + + Q Q ++++ ++K
Sbjct: 500 MWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 531
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 59.7 bits (143), Expect = 9e-09
Identities = 96/422 (22%), Positives = 174/422 (41%), Gaps = 79/422 (18%)
Query: 128 EDMYDEIIELKKSL-HVQKSDVDLMRTKLRRLEEENSR---KDRQIEQLLDPSRGTDFVR 183
E + + I E L H + + +LMR R+ +E ++ E+L + SR +
Sbjct: 1855 EKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRARE--- 1911
Query: 184 TLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDM--KTTNLEEMRIAMETYYE 241
LA + A VI+G E+Q +EK I +L+ ++ + L+E+ + E
Sbjct: 1912 QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQE 1971
Query: 242 EVHRL---------------QTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQ 286
E L Q LL +E K+ L + K + + + +L V+
Sbjct: 1972 ERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE 2031
Query: 287 E------------------LTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIV 328
E L ++NQ+L++ L+++ + + E + + I
Sbjct: 2032 EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDR---EHERDVFQQEIQ 2088
Query: 329 ELEKKLSVM------ESSKSHAAEPVRSH----PPAC---LASSSALHRQPRGDRNKDHE 375
+LE++L V+ ++ E + +H C L S L R + +RN++ E
Sbjct: 2089 KLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQ-ERNEEIE 2147
Query: 376 RLRGAVRDLK-----EERTALQEQLLQRDLEVKQLLQAKADL----EKELECAREGEEER 426
+L VR+L+ E+R + +L ++ LQA+ D EKE+ E E+
Sbjct: 2148 KLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQF 2207
Query: 427 REREEVLREEIQTL-----------TSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSS 475
RE E EE+Q L T++LQEL++ K K+D ++ +E A +
Sbjct: 2208 REELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQD 2267
Query: 476 RH 477
+H
Sbjct: 2268 QH 2269
Score = 51.6 bits (122), Expect = 2e-06
Identities = 70/348 (20%), Positives = 149/348 (42%), Gaps = 31/348 (8%)
Query: 135 IELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASW 194
I LK+ +K +L+ ++ ++++ + Q+E R T+ L+ ++ +
Sbjct: 3098 ITLKREQESEKPSQELLEYNIQ--QKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAE 3155
Query: 195 VINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSE 254
+ + L Q L+LE K + + +L E R+ ++ +EVH L LAS +
Sbjct: 3156 LKSELAQTKLELETTLKAQHKHLKEL---------EAFRLEVKDKTDEVHLLNDTLASEQ 3206
Query: 255 TTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQG 314
KK + K + K+G S R +EL + SL+ R L + + + +
Sbjct: 3207 ---KKSRELQWALEKEKAKLGR---SEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ 3260
Query: 315 YVEWSKPRLLRRIVELEKKLSV-----MESSKSHAAEPVRSHP-PACLASSSALHRQPRG 368
+ S+ ++ + + + +LS +E +E VR + L LH Q +
Sbjct: 3261 LLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQS 3320
Query: 369 DRNKDHER--------LRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR 420
R L+ + L+E+ + + E L + + LQ + +EK+ + R
Sbjct: 3321 SDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHR 3380
Query: 421 EGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
+ + +E ++++ L SK+++LQ +E+++ ++ + Q L
Sbjct: 3381 KTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL 3428
Score = 46.2 bits (108), Expect = 1e-04
Identities = 67/321 (20%), Positives = 138/321 (42%), Gaps = 61/321 (19%)
Query: 145 KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRIL 204
K + + T+L +LE S KD ++ Q + + + + + L+++I+
Sbjct: 2483 KGSIINLETRLLQLESTVSAKDLELTQCY---------KQIKDMQEQGQFETEMLQKKIV 2533
Query: 205 KLEQQCKEKDGT--ISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLG 262
L++ +EK +S++Q + A++ Y + QT+ + E T + L
Sbjct: 2534 NLQKIVEEKVAAALVSQIQLE-----------AVQEYAKFCQDNQTISSEPERTNIQNLN 2582
Query: 263 EKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPR 322
+ R+ ++GS + +L+ + EL E+Q ++ + TS + K Q VE ++
Sbjct: 2583 QL-----REDELGSDISALTLRISEL--ESQVVE------MHTSLILEKEQ--VEIAEKN 2627
Query: 323 LLRRIVELEKKLSVMESSKSHAAEPVRSHPPACL----ASSSALHRQPRGDRNKDHERLR 378
+L + +L + ++E ++ E + P + ++ H + E LR
Sbjct: 2628 VLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR 2687
Query: 379 GA-------VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREE 431
+ KE+ LQE+LL ++ + L+K+L R+ E +E+
Sbjct: 2688 AESVATKAELASYKEKAEKLQEELLVKETNM-------TSLQKDLSQVRDHLAEAKEKLS 2740
Query: 432 VLREEIQTLTSKLQELQEMKK 452
+L +E +T E+QE KK
Sbjct: 2741 ILEKEDET------EVQESKK 2755
Score = 44.7 bits (104), Expect = 3e-04
Identities = 73/368 (19%), Positives = 152/368 (41%), Gaps = 44/368 (11%)
Query: 136 ELKKSLHVQKSDVDLMRTKLRRLEEENS-------RKDRQIEQLLDPSRGTDFVRTLAEK 188
+L+K + + DV+ ++ LE+E + ++++ +E+ L+ R + L E+
Sbjct: 2018 DLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMR-----KFLDEQ 2072
Query: 189 RPDASWVINGLKQRILKLEQQCK--EKDGTISKLQT----------DMKTTNLEEMRIAM 236
D + +Q I KLEQQ K + IS+ QT KT E+ ++
Sbjct: 2073 AIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSK 2132
Query: 237 ETYY-------EEVHRLQTLLASSETT----GKKPLG--EKKTGAKRQKKMGSALLSLSR 283
E EE+ +L+ + E +K G E K + ++ + ++ R
Sbjct: 2133 EQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDR 2192
Query: 284 SVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSH 343
+E+T + L++ + + + + + + +E K R+ ELE++ + +
Sbjct: 2193 KEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEK 2252
Query: 344 AAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQL-LQRDLEV 402
++ L G + + + L E+ T LQ+QL + D +V
Sbjct: 2253 LGLAIKESDAMSTQDQHVLF----GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKV 2308
Query: 403 -KQLLQAKADLEKELECAREGEE-ERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPE 460
++ + DLE ++EC +E +R REE + + + + QEL + ++ +
Sbjct: 2309 IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHS 2368
Query: 461 VPHKAQEL 468
+ +A L
Sbjct: 2369 LSEEADSL 2376
Score = 43.9 bits (102), Expect = 5e-04
Identities = 79/353 (22%), Positives = 154/353 (43%), Gaps = 42/353 (11%)
Query: 125 REKEDMYDEIIEL---KKSLHVQKSDVDLMRTKLRRLEEENSRKD--RQIEQLLDPSRGT 179
REK++ E +EL + L +Q + T LR ++ D + +Q+L +
Sbjct: 219 REKDETMREFLELTEQSQKLQIQFQQLQASET-LRNSTHSSTAADLLQAKQQILTHQQQL 277
Query: 180 DFVRTLAE----KRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIA 235
+ L E K+ D + I+ L+++I E + +K +K + K T +EE+
Sbjct: 278 EEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTK 337
Query: 236 METYYEEVHRLQTLLASSETTGKKPLGE-KKTGAKRQKKMGSALLSLSRSVQELTEENQS 294
+ EE L+ L TT K LGE ++ ++ +++ + L L+ S Q+ + ++
Sbjct: 338 I--IEEEKKTLE--LKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE 393
Query: 295 LKEDLDRVLSTSPTISKTQGY----VEWSKPRLLRRIVELEKKLSVMESSK--SHAAEPV 348
+K+ + V K + V+ + R++ +L +L M + E +
Sbjct: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI 453
Query: 349 RSHPPACLASSSALHRQPRGDR------------NKDHERLRG-AVRDL--KEERTALQE 393
R H +A + + +G+ N+D +L A+ +L K + T Q+
Sbjct: 454 RQH----MAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQK 509
Query: 394 QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQE 446
+ L+ +L + +L+ K L+++LE E RE+ + R+ I SKL E
Sbjct: 510 EKLKEELGL--ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE 560
Score = 42.4 bits (98), Expect = 0.001
Identities = 65/343 (18%), Positives = 146/343 (42%), Gaps = 42/343 (12%)
Query: 138 KKSLHVQKSDVDLMRTKLRRLEEE--NSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWV 195
K +L +++ + L +KL+ L++ NS+ + Q+ + + + +R +++
Sbjct: 685 KDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE 744
Query: 196 INGLKQRILKLEQQCKEKDGTISKLQTDMKTTN---------LEEMRIAMETYYEEVHRL 246
+ L+ + LE+Q KEK+ + + ++ N LE+M + + T + RL
Sbjct: 745 VQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDM-LKIHTPVSQEERL 803
Query: 247 QTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTS 306
L S ++ K + EK+ ++ L EEN+ LK+ + + +
Sbjct: 804 -IFLDSIKSKSKDSVWEKE-------------------IEILIEENEDLKQ---QCIQLN 840
Query: 307 PTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQP 366
I K + +++ EL+++ + + K + + AL+ +
Sbjct: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900
Query: 367 RGDR-NKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEE 425
R N +++ +V D E++T + E L ++ K +L ++LE + + E
Sbjct: 901 HLQRINPTTVKMKSSVFD--EDKTFVAETLEMGEVVEKD----TTELMEKLEVTKREKLE 954
Query: 426 RREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
+R L E+++ ++ L E K K++ +V + +EL
Sbjct: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCREL 997
Score = 42.0 bits (97), Expect = 0.002
Identities = 69/350 (19%), Positives = 147/350 (42%), Gaps = 47/350 (13%)
Query: 126 EKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTL 185
E E+ +E+ +L L +QK + T+L+ LE+EN +E+L + +D + T
Sbjct: 2210 ELENKNEEVQQLHMQLEIQKKE---STTRLQELEQENKLFKDDMEKLGLAIKESDAMST- 2265
Query: 186 AEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMK-TTNLEEMRIAMETYYEEVH 244
D + Q I + E + + + ++KLQ +K TT+ + + E +
Sbjct: 2266 ----QDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLET 2321
Query: 245 RLQTLLASSETTGKKPLGE----KKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLD 300
+++ L++ E + E + K Q+++ + S + L+EE SLK LD
Sbjct: 2322 QIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLD 2381
Query: 301 RVLSTS-------PTISKTQGYVE-------WSKPRLLRRIVEL-------EKKLSVMES 339
V++ T ++ +++ + +L + + L EK S+ E+
Sbjct: 2382 VVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPEN 2441
Query: 340 SKSHAAEPVRSHPP---ACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLL 396
S + A + + P L + + + E +G++ +L+ L+ +
Sbjct: 2442 SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVS 2501
Query: 397 QRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQE 446
+DLE+ Q + D+ +E+ + E+L+++I L ++E
Sbjct: 2502 AKDLELTQCYKQIKDM----------QEQGQFETEMLQKKIVNLQKIVEE 2541
Score = 40.0 bits (92), Expect = 0.007
Identities = 71/307 (23%), Positives = 132/307 (42%), Gaps = 51/307 (16%)
Query: 153 TKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKE 212
T L +E E + K +IE+L R L E R ++ GL+Q + + E K+
Sbjct: 155 THLEMMESELAGKQHEIEELN---------RELEEMR--VTYGTEGLQQ-LQEFEAAIKQ 202
Query: 213 KDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAK--- 269
+DG I++L T NL++ R E+ ++ L +E + K + ++ A
Sbjct: 203 RDGIITQL-----TANLQQAR------REKDETMREFLELTEQSQKLQIQFQQLQASETL 251
Query: 270 RQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVE 329
R S L ++ Q++ Q L+E D +L K ++ S + ++ E
Sbjct: 252 RNSTHSSTAADLLQAKQQILTHQQQLEEQ-DHLLEDYQK-KKEDFTMQISFLQEKIKVYE 309
Query: 330 LEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERT 389
+E+ V S+K E ++ + + + KD +L A + L E
Sbjct: 310 MEQDKKVENSNKEEIQEKETIIEEL---NTKIIEEEKKTLELKD--KLTTADKLLGE--- 361
Query: 390 ALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQE 449
LQEQ++Q++ E+K + +LE ++ER+ EEI+ L ++ELQ+
Sbjct: 362 -LQEQIVQKNQEIKNM---------KLELTNSKQKERQ-----SSEEIKQLMGTVEELQK 406
Query: 450 MKKEEKE 456
++ +
Sbjct: 407 RNHKDSQ 413
Score = 40.0 bits (92), Expect = 0.007
Identities = 78/358 (21%), Positives = 143/358 (39%), Gaps = 68/358 (18%)
Query: 126 EKEDMYDEIIELKKSLHVQKSDV-----DLMRTKLRRLEEENSRKDRQIEQL----LDPS 176
E M D EL++ L +K V +L +TKL LE + + +++L L+
Sbjct: 3131 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLE-LETTLKAQHKHLKELEAFRLEVK 3189
Query: 177 RGTDFVRTLAE-------KRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNL 229
TD V L + K + W + K ++ + E++ KE+ L
Sbjct: 3190 DKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEE---------------L 3234
Query: 230 EEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRS----V 285
E+++ ++E+ + +L LL K+ L E + + Q+ + A LS + +
Sbjct: 3235 EDLKFSLESQKQRNLQLNLLLEQQ----KQLLNESQQKIESQRMLYDAQLSEEQGRNLEL 3290
Query: 286 QELTEENQ----SLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRR--IVELEKKLSVMES 339
Q L E + + LDR + + G + S+P L + EL+K+L S
Sbjct: 3291 QVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQ-SRPPLPSEDLLKELQKQLEEKHS 3349
Query: 340 SKSHAAEPVRSHPPACLASSSALHRQPRGDRN--------------KDHERLRGAVRDLK 385
+ L + + + + R K HE L+ V DL+
Sbjct: 3350 RIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHE-LQSKVEDLQ 3408
Query: 386 EERTALQEQLLQRDLEVKQLLQAKADLEK-ELECAREGEEERREREEVLREEIQTLTS 442
+ ++Q+ + DLE ++L + +K ELE EE+RE +L + + T+
Sbjct: 3409 RQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELE-----REEKRESRRILYQNLNEPTT 3461
Score = 39.7 bits (91), Expect = 0.009
Identities = 76/343 (22%), Positives = 136/343 (39%), Gaps = 58/343 (16%)
Query: 148 VDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLE 207
V L+ +R++E+ +E L R R+L + +NG K LK E
Sbjct: 3050 VGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RSLLSEIQALHAQMNGRKIT-LKRE 3103
Query: 208 QQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTG 267
Q+ ++ + + K + + EM++ + + + LQ L+S K + E K+
Sbjct: 3104 QESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSE----KMVVAELKSE 3159
Query: 268 AKRQK-KMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRR 326
+ K ++ + L + + ++EL +K+ D V + T++ Q K R L+
Sbjct: 3160 LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQ-----KKSRELQW 3214
Query: 327 IVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKE 386
+E EK + ER + + DLK
Sbjct: 3215 ALEKEK-----------------------------------AKLGRSEERDKEELEDLK- 3238
Query: 387 ERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQE 446
+L+ Q QR+L++ LL+ + L E + ++ E +R + L EE Q +LQ
Sbjct: 3239 --FSLESQK-QRNLQLNLLLEQQKQLLNESQ--QKIESQRMLYDAQLSEE-QGRNLELQV 3292
Query: 447 LQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEE 489
L E +K + + +EL A SS Q PP SE+
Sbjct: 3293 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSED 3335
Score = 39.3 bits (90), Expect = 0.012
Identities = 82/382 (21%), Positives = 164/382 (42%), Gaps = 61/382 (15%)
Query: 124 YREKEDMYDEIIELKKSLHVQKSDVDL-MRTKLRRLEEENSRKDRQIEQLLDPSRGTDFV 182
Y+E ++ Y ++++K L K+ +L ++KL+ L EE + + S D
Sbjct: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 920
Query: 183 RTLAEKRPDASWVING------------------LKQRILKLEQQCKEKDGTISKLQTDM 224
+T + + V+ L QR+ L +Q K+K G IS L ++
Sbjct: 921 KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV 980
Query: 225 KTTNLEEMRIAMETYYEEV---HRLQTLLASSETTGKKPL---------GEKKTGAKRQK 272
K+ E+ ++++ E+ H + S +T L G + + +K K
Sbjct: 981 KSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNK 1040
Query: 273 KMG---SALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVE 329
G ++ S + +T +S +E L +L P+++K + + ++P +
Sbjct: 1041 SFGEESKIMVEDKVSFENMTVGEESKQEQL--ILDHLPSVTK-ESSLRATQP---SENDK 1094
Query: 330 LEKKLSVMESSKSHAAEPVRSHPPACLASSSALH-RQPRGDRNKDHERLRGAVRDLKEER 388
L+K+L+V++S ++ + + CL+ + H Q R + ++ A+ LKEE
Sbjct: 1095 LQKELNVLKSEQNDLRLQMEAQ-RICLSLVYSTHVDQVREYMENEKDK---ALCSLKEEL 1150
Query: 389 TALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEER---REREEVLREE----IQTLT 441
QE+ ++ E++++ Q + K E EG+ + ++ + EE +QTL
Sbjct: 1151 IFAQEEKIK---ELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLC 1207
Query: 442 SKLQELQ------EMKKEEKED 457
S L E E+ E+KE+
Sbjct: 1208 SVLGEYYTPALKCEVNAEDKEN 1229
Score = 33.9 bits (76), Expect = 0.51
Identities = 74/366 (20%), Positives = 154/366 (42%), Gaps = 48/366 (13%)
Query: 128 EDMY--DEIIELKKSLH--VQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVR 183
E+M+ D+ +++S+H + S +D R + E+ + + Q + + T+ +R
Sbjct: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLR 1609
Query: 184 T-----LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISK-LQTDMKTTNLEEMRIAME 237
+ +R D L++ I +L +Q ++ ++ L ++ + LEE+ +
Sbjct: 1610 QAHMRQMERQREDQEQ----LQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQ 1665
Query: 238 TYYEEVHRLQTLLASSET---TGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQS 294
+L L +S T G + GE + ++K++ + + L+ E +
Sbjct: 1666 LSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEI--LSNERYA 1723
Query: 295 LKEDLDRVLSTSPTISKTQGYVEWSKPR----LLRRIVELEKKLSVMESSKSHAAEPVRS 350
L++ +R+L + KT VE + R +L R + + S++ S++ A+
Sbjct: 1724 LQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCV 1783
Query: 351 HPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQR-------DLEVK 403
H + ++ D ++ + V EE T L ++L++ D E +
Sbjct: 1784 HEEHTRVTDESIPSYSGSDMPRNDINMWSKVT---EEGTELSQRLVRSGFAGTEIDPENE 1840
Query: 404 QLL-----QAKADLEKELECAREG----EEERREREEVLREEI---QTLTSKL---QELQ 448
+L+ + +A +EK LE E E + + E++RE Q T L +EL+
Sbjct: 1841 ELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELR 1900
Query: 449 EMKKEE 454
E EE
Sbjct: 1901 ERLHEE 1906
>gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo
sapiens]
Length = 1002
Score = 59.3 bits (142), Expect = 1e-08
Identities = 74/349 (21%), Positives = 148/349 (42%), Gaps = 46/349 (13%)
Query: 136 ELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWV 195
++ + +H + + + ++++ LE + Q+ + P + + +A +
Sbjct: 413 QMSEQVHTLREEKECSMSRVQELETSLAELRNQMAEPPPPEPPAGPSEVEQQLQAEAEHL 472
Query: 196 INGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSE- 254
L+ +L+ Q ++ +G +S+L + + LE R A E + E+ + +L + +
Sbjct: 473 RKELEGLAGQLQAQVQDNEG-LSRLNREQEERLLELERAA-ELWGEQAEARRQILETMQN 530
Query: 255 --TTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKT 312
TT + L + + ++ ++ S + L+ E+T QS +
Sbjct: 531 DRTTISRALSQNRELKEQLAELQSGFVKLTNENMEITSALQSEQH--------------- 575
Query: 313 QGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNK 372
K L +++ EL++KLS ++ + L S A Q + D+
Sbjct: 576 ------VKRELGKKLGELQEKLSELKETVE-------------LKSQEAQSLQQQRDQYL 616
Query: 373 DH-ERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREE 431
H ++ A + L E+ L QLL + V QL Q +A + E AR+ +E +ER E
Sbjct: 617 GHLQQYVAAYQQLTSEKEVLHNQLLLQTQLVDQLQQQEAQGKAVAEMARQELQETQERLE 676
Query: 432 VLREEIQTLTSKLQ------ELQEMKKEEKEDCPEVPHKAQELPAPTPS 474
++ Q L ++L E + +EE+ED E +A +P P PS
Sbjct: 677 AATQQNQQLRAQLSLMAHPGEGDGLDREEEEDEEEEEEEAVAVPQPMPS 725
Score = 46.6 bits (109), Expect = 8e-05
Identities = 76/387 (19%), Positives = 141/387 (36%), Gaps = 54/387 (13%)
Query: 126 EKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTL 185
E E + E+ L L Q D + L RL E Q E+LL+ R +
Sbjct: 468 EAEHLRKELEGLAGQLQAQVQDNE----GLSRLNRE------QEERLLELERAAELWGEQ 517
Query: 186 AEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEE--- 242
AE R + + I + Q +E +++LQ+ E M I E+
Sbjct: 518 AEARRQILETMQNDRTTISRALSQNRELKEQLAELQSGFVKLTNENMEITSALQSEQHVK 577
Query: 243 ------VHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLK 296
+ LQ L+ + T + E ++ +++ + L + Q+LT E + L
Sbjct: 578 RELGKKLGELQEKLSELKETVELKSQEAQSLQQQRDQYLGHLQQYVAAYQQLTSEKEVLH 637
Query: 297 EDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKL--SVMESSKSHAAEPVRSHPPA 354
L + + + + + + E +++L + ++ + A + +HP
Sbjct: 638 NQLLLQTQLVDQLQQQEAQGKAVAEMARQELQETQERLEAATQQNQQLRAQLSLMAHP-- 695
Query: 355 CLASSSALHRQPRGDRNKDHER------------------------LRGAVRDLKEERTA 390
L R+ D ++ E AV +EE+
Sbjct: 696 --GEGDGLDREEEEDEEEEEEEAVAVPQPMPSIPEDLESREAMVAFFNSAVASAEEEQAR 753
Query: 391 LQEQLLQRDLEVKQLLQAKADLEKELECARE-----GEEERREREEVLREEIQTLTSKLQ 445
L+ QL ++ + ++L A +KE E A G+ E L+ ++ L S+
Sbjct: 754 LRGQLKEQRVRCRRLAHLLASAQKEPEAAAPAPGTGGDSVCGETHRALQGAMEKLQSRFM 813
Query: 446 ELQEMKKEEKEDCPEVPHKAQELPAPT 472
EL + K + KE E+ H+ +L T
Sbjct: 814 ELMQEKADLKERVEELEHRCIQLSGET 840
Score = 37.7 bits (86), Expect = 0.035
Identities = 75/370 (20%), Positives = 135/370 (36%), Gaps = 57/370 (15%)
Query: 175 PSRGTDFVRTLAEKRPDASWVINGLKQR--------ILKLEQQ----------CKEKDGT 216
PS G A + DA V N + + + +L QQ C +G
Sbjct: 91 PSPGASLTSMAASQNHDADNVPNLMDETKTFSSTESLRQLSQQLNGLVCESATCVNGEGP 150
Query: 217 ISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLG----EKKTGAKRQK 272
S + +++ +A+++ Y +L + + ++ EKK ++Q
Sbjct: 151 ASSANLKDLESRYQQLAVALDSSYVTNKQLNITIEKLKQQNQEITDQLEEEKKECHQKQG 210
Query: 273 KMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLL---RRIVE 329
+ L +++ L E L+ L T + +G E RL RR+ E
Sbjct: 211 ALREQLQVHIQTIGILVSEKAELQTALAH---TQHAARQKEGESEDLASRLQYSRRRVGE 267
Query: 330 LEKKLSVMESSKSHAAEPVRSHPPACLASSSALHR--QPRGDRNKDHERLRGAVRDLKEE 387
LE+ LS + + + A + A L++ Q D ++ L +R L E
Sbjct: 268 LERALSAVSTQQKKADRYNKELTKERDALRLELYKNTQSNEDLKQEKSELEEKLRVLVTE 327
Query: 388 RTALQEQL--LQRDLEVKQLL-------------------------QAKADLEKELECAR 420
+ +Q L LQ+ LE+ +LL Q +A L + +E R
Sbjct: 328 KAGMQLNLEELQKKLEMTELLLQQFSSRCEAPDANQQLQQAMEERAQLEAHLGQVMESVR 387
Query: 421 EGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQ 480
+ + ER + E L+ E ++Q++ E +E+ + QEL R+
Sbjct: 388 QLQMERDKYAENLKGESAMWRQRMQQMSEQVHTLREEKECSMSRVQELETSLAELRNQMA 447
Query: 481 DWPPDSSEEG 490
+ PP G
Sbjct: 448 EPPPPEPPAG 457
Score = 37.7 bits (86), Expect = 0.035
Identities = 66/370 (17%), Positives = 140/370 (37%), Gaps = 36/370 (9%)
Query: 126 EKEDMYDEII-------ELKKSLHVQKSDVDLMRTKLRRLEE-------ENSRKDRQIEQ 171
EKE ++++++ +L++ K+ ++ R +L+ +E +N + Q+
Sbjct: 632 EKEVLHNQLLLQTQLVDQLQQQEAQGKAVAEMARQELQETQERLEAATQQNQQLRAQLSL 691
Query: 172 LLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEE 231
+ P G R E + + Q + + + + ++ ++ + + + E+
Sbjct: 692 MAHPGEGDGLDREEEEDEEEEEEEAVAVPQPMPSIPEDLESREAMVAFFNSAVASAEEEQ 751
Query: 232 MRIAMETYYEEVH--RLQTLLASSETTGKKPLGEKKTGA-----KRQKKMGSALLSLSRS 284
R+ + + V RL LLAS++ + TG + + + A+ L
Sbjct: 752 ARLRGQLKEQRVRCRRLAHLLASAQKEPEAAAPAPGTGGDSVCGETHRALQGAMEKLQSR 811
Query: 285 VQELTEENQSLKEDLD-------RVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVM 337
EL +E LKE ++ ++ + TI + + + L R E E+ +S +
Sbjct: 812 FMELMQEKADLKERVEELEHRCIQLSGETDTIGEYIALYQSQRAVLKERHREKEEYISRL 871
Query: 338 ESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQ 397
K L L + GDRN+ H R A ++ +E T+ +
Sbjct: 872 AQDKEEMKVK--------LLELQELVLRLVGDRNEWHGRFLAAAQNPADEPTSGAPAPQE 923
Query: 398 RDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKED 457
+Q + L +E A+ E R+ ++I L ++Q +E
Sbjct: 924 LGAANQQGDLCEVSLAGSVEPAQGEAREGSPRDNPTAQQIMQLLREMQNPRERPGLGSNP 983
Query: 458 CPEVPHKAQE 467
C ++A E
Sbjct: 984 CIPFFYRADE 993
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 58.9 bits (141), Expect = 1e-08
Identities = 78/378 (20%), Positives = 172/378 (45%), Gaps = 50/378 (13%)
Query: 110 RRSASNGHVPGTPVYREKEDMYDEIIELKKSLH------------VQKSDV---DLMRTK 154
+ + S G P T R+ + E+ E K SL +++S++ L T+
Sbjct: 1981 KETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTR 2040
Query: 155 LRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKD 214
+R+ + RK + + L R +L+++ + ++ L Q++ + E++ +++
Sbjct: 2041 GQRIFVQGQRKLAKASRKLIKKR-----ESLSKEPAKLNKILKAL-QKLTRDERKLTQEE 2094
Query: 215 GTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKM 274
++K++ + ++E R+++E ++ SE T ++K A++Q+K+
Sbjct: 2095 IKMTKMK---RALFVKERRLSIEQSKLDIKEWDFSEKRSELTK-----DEKKLARKQRKL 2146
Query: 275 GSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVE-----------WSKPRL 323
+ + + +++TEE L V+ + +G +E W K +
Sbjct: 2147 ANKMRRMINKEEKMTEEESKLARKHSEVILDD----EEEGGIEEEEVIPFLKRRWRKRKE 2202
Query: 324 LRRIVELEKKLSVMES---SKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGA 380
+R + ++K S S+ H +E + S L +L + +R ++ ER
Sbjct: 2203 AKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDE-LEKQESLSSEEEEEREEEEEREEEE 2261
Query: 381 VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVL-REEIQT 439
VR+ +EER +E+ ++ +E ++ + K EK+ E +E EE E+EE++ EE ++
Sbjct: 2262 VREEEEERKE-EEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETES 2320
Query: 440 LTSKLQELQEMKKEEKED 457
L+ + +E + EE+ D
Sbjct: 2321 LSDEEEEEESCSLEEEVD 2338
Score = 43.5 bits (101), Expect = 6e-04
Identities = 65/336 (19%), Positives = 138/336 (41%), Gaps = 37/336 (11%)
Query: 132 DEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPD 191
+E+ + +++L Q+ ++ +L EE S K+ ++ Q + + + + LAE+
Sbjct: 1698 EELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQ--EEGKLVEEKKKLAEEEEA 1755
Query: 192 ASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIA------METYYEEVHR 245
+W L + KL Q+ + KL + EE R+ +E + +
Sbjct: 1756 LAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQK 1815
Query: 246 LQTLLASSETTGKKPL---------GEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLK 296
+ + S E K + EKK A+ ++K+ +L + + LT + L
Sbjct: 1816 RERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLV 1875
Query: 297 EDLDRVLSTSPTISKTQGYVEWSKPRLLRR---IVELEKKLSVMESSKSHAAEPVRSHPP 353
+ +++ + +++ + + K ++++ + E EKKL +E S + E +
Sbjct: 1876 QVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKM 1935
Query: 354 ACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE 413
+ + + +RLRG + KEE+ +LE+K+L + K L
Sbjct: 1936 KLALEKAMVQGK---------KRLRGELDIAKEEKAL--------NLEMKRLAEEKMRLV 1978
Query: 414 KELECAREGEEERREREEVLREEIQTLTSKLQELQE 449
+ E +GE R+ + + Q L + L+E
Sbjct: 1979 EGKETLSKGETPETSRQRKMTQVEQELFERKLSLEE 2014
Score = 37.7 bits (86), Expect = 0.035
Identities = 65/312 (20%), Positives = 125/312 (40%), Gaps = 42/312 (13%)
Query: 158 LEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTI 217
LEEE SR+ + EQ + T+ R + E+ A I+ + R K Q + K
Sbjct: 1546 LEEEVSREGEEKEQQV-----TEEQRHIQEEHKWAR--IHRKRARAEKKRAQEERKLAQE 1598
Query: 218 S-KLQTDMKTTNLEEMRIAMETYYE------EVHRLQTLLASSETT----GKKPLGEKKT 266
KL + + EE ++A + Y + E+ + + A E T G+K E +
Sbjct: 1599 EEKLAQEERQLAQEERKLA-QAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEK 1657
Query: 267 GAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRR 326
A+++KK+ ++R ++L ++ L E + + + + + ++W + L +
Sbjct: 1658 LAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQE 1717
Query: 327 IVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKE 386
+ ELE + + + Q G ++ ++L L
Sbjct: 1718 LEELEWDMEELSWKEEEL-------------------NQEEGKLVEEKKKLAEEEEALAW 1758
Query: 387 ERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSK--- 443
+R L E+ + E + L+Q K L + E E EE + E L E+ L K
Sbjct: 1759 QREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRER 1818
Query: 444 -LQELQEMKKEE 454
+ ++E+ K +
Sbjct: 1819 WINSMEELTKNK 1830
Score = 36.6 bits (83), Expect = 0.078
Identities = 58/298 (19%), Positives = 123/298 (41%), Gaps = 17/298 (5%)
Query: 204 LKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGE 263
LK E+ + + +S + + + EE+ T EEV R T ++ + E
Sbjct: 1516 LKWEEWKQVWENMLSSKSKEQQYKDEEEV-----TLEEEVSREGEEKEQQVTEEQRHIQE 1570
Query: 264 KKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRL 323
+ A+ +K A ++ ++L +E + L ++ ++ ++ Q YV+ ++
Sbjct: 1571 EHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLA--QAYVKITQDD- 1627
Query: 324 LRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLR--GAV 381
R + + E K + E + + E + L ++ ++ + + G +
Sbjct: 1628 -REMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKL 1686
Query: 382 RDLKEERTALQEQLLQR----DLEVKQLLQAKADLEKELECAREGEEERREREEVLREEI 437
++K E+L QR D + K+L Q +LE ++E EEE + E L EE
Sbjct: 1687 AEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEK 1746
Query: 438 QTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPR 495
+ L + + L +++ E+ ++ + + L ++ P + EE L R R
Sbjct: 1747 KKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEE--EERLGRKR 1802
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 58.9 bits (141), Expect = 1e-08
Identities = 69/347 (19%), Positives = 147/347 (42%), Gaps = 27/347 (7%)
Query: 125 REKEDMYDEIIELKKSLH---VQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF 181
R++ + +EI+ LK S K++++L ++R E+ R Q E L+ +R
Sbjct: 1918 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAARQRQL 1975
Query: 182 VRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
+R +A + Q+ L E++ + + LEE+ ++ E
Sbjct: 1976 AAEEERRRREAEERV----QKSLAAEEEAARQ-----------RKAALEEVE-RLKAKVE 2019
Query: 242 EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDR 301
E RL+ A E+ + L ++ + Q + + ++ + QEL + Q + LD+
Sbjct: 2020 EARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078
Query: 302 VLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
+ + + E ++ + R + +++ E K A E ++ A + A
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-----AQAQA 2133
Query: 362 LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
+ R + ++ R A + ++ A ++ + +Q L+ KA +E+EL R
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2193
Query: 422 GEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
EE ++ +L EE+Q L ++ E + + +E+ V + +EL
Sbjct: 2194 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2240
Score = 57.8 bits (138), Expect = 3e-08
Identities = 80/384 (20%), Positives = 161/384 (41%), Gaps = 60/384 (15%)
Query: 125 REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
+EK E LK + + +L + + RRL+E+ K++ +QL + ++G F RT
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQG--FQRT 2367
Query: 185 LAEKRPDASWVINGLKQRILKLE---QQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
L +R QR L++ ++ K + +S+ Q + + + R E E
Sbjct: 2368 LEAER-----------QRQLEMSAEAERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGE 2415
Query: 242 EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQ--SLKEDL 299
++HR + T + +++ +++ A+ L R ++L +E + LK +
Sbjct: 2416 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2475
Query: 300 DRVLSTSPTISKTQGYVEW---SKPRLLRR--IVELEK-KLSVMESSKSHAAEPVRSHPP 353
+ + + +TQ + K LL+R +E EK KL + + A+ +R
Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-- 2533
Query: 354 ACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE 413
++ + ++ +RL ++ + + + +E + ++ E++QL
Sbjct: 2534 ---------QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL-------- 2576
Query: 414 KELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTP 473
E++RR++EE+L EE Q L +LQ L+E + EV P
Sbjct: 2577 ---------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2627
Query: 474 SSRHC----EQDWPPDSSEEGLPR 493
+ R + P+ S +GL R
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRR 2651
Score = 50.4 bits (119), Expect = 5e-06
Identities = 82/370 (22%), Positives = 162/370 (43%), Gaps = 46/370 (12%)
Query: 101 TFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLR---- 156
+F K L RS HV + E E + E +++ + +++ + K
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643
Query: 157 -RLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRIL---KLEQQCKE 212
RL+ E + + + Q + + + A +R A ++QR L +LE+Q +
Sbjct: 1644 LRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQL 1700
Query: 213 KDGTISK--------LQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEK 264
+GT + ++ +T E+ R +E EE+ RLQ A++ T K+ E
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE---EELARLQREAAAA--TQKRQELEA 1755
Query: 265 KTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLL 324
+ AK + +M L S +R+ +E ++ K+ L+ +++ E ++ R L
Sbjct: 1756 EL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRAL 1809
Query: 325 RRIVELEKKLSVMESSKSHA-AEPVRSHPPACLASSSALHRQPR---GDRNKDHERLRGA 380
+ +++L+ ++++ A AE V + A + ++ L + ++ ++ERLR
Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869
Query: 381 VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTL 440
D +R L+EQ Q KAD+E+ L R+ + ER++ L E+ TL
Sbjct: 1870 AEDEAFQRRRLEEQAAQH----------KADIEERLAQLRKASDSELERQKGLVED--TL 1917
Query: 441 TSKLQELQEM 450
+ Q +E+
Sbjct: 1918 RQRRQVEEEI 1927
Score = 40.8 bits (94), Expect = 0.004
Identities = 59/271 (21%), Positives = 107/271 (39%), Gaps = 37/271 (13%)
Query: 199 LKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGK 258
L R+ + +EK + L+ +++ E R + E ++Q L +++ + +
Sbjct: 1517 LASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 259 KPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEW 318
L K+ L RS+QE L+E+ +R + Q E
Sbjct: 1576 AELQSKRAS------FAEKTAQLERSLQEEHVAVAQLREEAER---------RAQQQAEA 1620
Query: 319 SKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLR 378
+ R E E++L E + A E +R A + Q ++ K+
Sbjct: 1621 ERAR-----EEAEREL---ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1672
Query: 379 GAVRDLKEERTALQEQLLQRDLEVKQLL-----QAKADLEKELECAREGEEERREREEVL 433
R EE+ Q +L +++LE ++ L Q + E+EL R E+ ++ ++L
Sbjct: 1673 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1732
Query: 434 REEIQTL-------TSKLQELQ-EMKKEEKE 456
EE+ L T K QEL+ E+ K E
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAE 1763
Score = 39.7 bits (91), Expect = 0.009
Identities = 64/353 (18%), Positives = 137/353 (38%), Gaps = 32/353 (9%)
Query: 145 KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRI- 203
K +L + R+L E R+ R+ E+ + S + A +R A + LK ++
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVERLKAKVE 2019
Query: 204 --LKLEQQCKEKDGTISKLQTD--MKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKK 259
+L ++ +++ +L + K EE A +E LQ L ++ +
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQTLQQEQSVLDQ 2078
Query: 260 PLGEKKTGAKRQKKMGSALLSLSRS-------VQELTEENQSLKEDLDRVLSTSPTISKT 312
GE + + ++ A + R V+E QS +E K
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2138
Query: 313 QGYVEWSKPRLLR-RIVELEKKLSV---MESSKSHAAEPVRSHPPACLASSSALHRQPRG 368
+ E R + L +K + ME K A + +R ++ +
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198
Query: 369 DRNK-----DHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE--------KE 415
D K + +RL+ + +R+ ++E+L +++++L + KA +E ++
Sbjct: 2199 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2258
Query: 416 LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
+ + +E E+ + + EE L+ QE +++ +ED + A+++
Sbjct: 2259 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311
Score = 39.3 bits (90), Expect = 0.012
Identities = 60/262 (22%), Positives = 108/262 (41%), Gaps = 33/262 (12%)
Query: 230 EEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQ---------KKMGSALLS 280
EE R+A + EE RL + A+ E ++ L E AK Q ++M ++
Sbjct: 1346 EEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 281 LSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGY----VEWSKPRLLRRIVELEKKLSV 336
+ + ++ +S++E+L ++ +S + + E S+ R+ I + +L
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1463
Query: 337 MESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLL 396
E + A ++ A A + Q R ++ ERLR V+D + + + +L
Sbjct: 1464 TERQRGGAEGELQ----ALRARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELA 1518
Query: 397 QR-------DLEVKQLLQAKADLEKELECA----REGEEERREREEVLREEIQTLTSKLQ 445
R E ++ LQA +L + E A R+ E ER + +V E Q S
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEA 1576
Query: 446 ELQEMKKEEKEDCPEVPHKAQE 467
ELQ + E ++ QE
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQE 1598
Score = 38.1 bits (87), Expect = 0.027
Identities = 82/418 (19%), Positives = 159/418 (38%), Gaps = 75/418 (17%)
Query: 118 VPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR 177
+ GT E ++E ++ +++ +++ + L++L + + + L D R
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1154
Query: 178 GTDFV-RTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAM 236
G V L ++ + + ++R+ +L ++ + QTD++ LE++ +
Sbjct: 1155 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV-----LAQTDVRQRELEQLGRQL 1209
Query: 237 ETYYEEVHRLQTLLASS----ETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEEN 292
Y E L L + E PL + + + Q + ALL E EE
Sbjct: 1210 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQA-VREQLRQEQALLEEIERHGEKVEEC 1268
Query: 293 Q------------------SLKEDLDRVLST-------SPTISKTQGYVE----WSKPRL 323
Q + K L+ V S S + S Q YV+ +S+
Sbjct: 1269 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1328
Query: 324 L--RRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAV 381
L + I + + L ME + AE R+ LA A + R + A
Sbjct: 1329 LTSQYIKFISETLRRMEEEE-RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1387
Query: 382 RDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEE----------ERRER-- 429
R+ KE + +QE++++R+ Q K +++EL+ R+ E E ER
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 430 ---EEVLRE-----------------EIQTLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
EE +R E+Q L ++ +E + K++ +E+ + + Q+
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1505
Score = 36.6 bits (83), Expect = 0.078
Identities = 51/260 (19%), Positives = 97/260 (37%), Gaps = 40/260 (15%)
Query: 201 QRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKP 260
QR + E Q K Q + +L+E +A+ EE R A + ++
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR----AQQQAEAERA 1623
Query: 261 LGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSK 320
E + +R + + L L +E+ ++ + + ++ + ++ +G E
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 321 PRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGA 380
R +++L+ E K LA +A Q R ++ RLR
Sbjct: 1684 VR--------QRELAEQELEKQRQ-----------LAEGTA---QQRLAAEQELIRLRAE 1721
Query: 381 VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR-----------EGEEERRER 429
+++R L+E+L + E Q + +LE EL R EEE R
Sbjct: 1722 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1781
Query: 430 EEVLREEIQTLTSKLQELQE 449
E ++ ++ + +EL E
Sbjct: 1782 SEKSKQRLEAEAGRFRELAE 1801
Score = 32.3 bits (72), Expect = 1.5
Identities = 31/180 (17%), Positives = 73/180 (40%), Gaps = 11/180 (6%)
Query: 281 LSRSVQELTEEN----QSLKEDLDRVLSTSPTISKTQGYVE---WSKPRLLRRIVELEKK 333
+S +++ + EE Q E+ +R+ + K + E +K + R EL+++
Sbjct: 1337 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1396
Query: 334 LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
+ + AA + + L + + + A R R ++E
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS----RLRIEE 1452
Query: 394 QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
++ L+++ + + E EL+ R EE ++ +EE + L ++Q+ + K++
Sbjct: 1453 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 58.9 bits (141), Expect = 1e-08
Identities = 69/347 (19%), Positives = 147/347 (42%), Gaps = 27/347 (7%)
Query: 125 REKEDMYDEIIELKKSLH---VQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF 181
R++ + +EI+ LK S K++++L ++R E+ R Q E L+ +R
Sbjct: 1922 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAARQRQL 1979
Query: 182 VRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
+R +A + Q+ L E++ + + LEE+ ++ E
Sbjct: 1980 AAEEERRRREAEERV----QKSLAAEEEAARQ-----------RKAALEEVE-RLKAKVE 2023
Query: 242 EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDR 301
E RL+ A E+ + L ++ + Q + + ++ + QEL + Q + LD+
Sbjct: 2024 EARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2082
Query: 302 VLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
+ + + E ++ + R + +++ E K A E ++ A + A
Sbjct: 2083 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-----AQAQA 2137
Query: 362 LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
+ R + ++ R A + ++ A ++ + +Q L+ KA +E+EL R
Sbjct: 2138 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2197
Query: 422 GEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
EE ++ +L EE+Q L ++ E + + +E+ V + +EL
Sbjct: 2198 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2244
Score = 57.8 bits (138), Expect = 3e-08
Identities = 80/384 (20%), Positives = 161/384 (41%), Gaps = 60/384 (15%)
Query: 125 REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
+EK E LK + + +L + + RRL+E+ K++ +QL + ++G F RT
Sbjct: 2317 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQG--FQRT 2371
Query: 185 LAEKRPDASWVINGLKQRILKLE---QQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
L +R QR L++ ++ K + +S+ Q + + + R E E
Sbjct: 2372 LEAER-----------QRQLEMSAEAERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGE 2419
Query: 242 EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQ--SLKEDL 299
++HR + T + +++ +++ A+ L R ++L +E + LK +
Sbjct: 2420 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2479
Query: 300 DRVLSTSPTISKTQGYVEW---SKPRLLRR--IVELEK-KLSVMESSKSHAAEPVRSHPP 353
+ + + +TQ + K LL+R +E EK KL + + A+ +R
Sbjct: 2480 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-- 2537
Query: 354 ACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE 413
++ + ++ +RL ++ + + + +E + ++ E++QL
Sbjct: 2538 ---------QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL-------- 2580
Query: 414 KELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTP 473
E++RR++EE+L EE Q L +LQ L+E + EV P
Sbjct: 2581 ---------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2631
Query: 474 SSRHC----EQDWPPDSSEEGLPR 493
+ R + P+ S +GL R
Sbjct: 2632 NGRDALDGPAAEAEPEHSFDGLRR 2655
Score = 50.4 bits (119), Expect = 5e-06
Identities = 82/370 (22%), Positives = 162/370 (43%), Gaps = 46/370 (12%)
Query: 101 TFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLR---- 156
+F K L RS HV + E E + E +++ + +++ + K
Sbjct: 1588 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1647
Query: 157 -RLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRIL---KLEQQCKE 212
RL+ E + + + Q + + + A +R A ++QR L +LE+Q +
Sbjct: 1648 LRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQL 1704
Query: 213 KDGTISK--------LQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEK 264
+GT + ++ +T E+ R +E EE+ RLQ A++ T K+ E
Sbjct: 1705 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE---EELARLQREAAAA--TQKRQELEA 1759
Query: 265 KTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLL 324
+ AK + +M L S +R+ +E ++ K+ L+ +++ E ++ R L
Sbjct: 1760 EL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRAL 1813
Query: 325 RRIVELEKKLSVMESSKSHA-AEPVRSHPPACLASSSALHRQPR---GDRNKDHERLRGA 380
+ +++L+ ++++ A AE V + A + ++ L + ++ ++ERLR
Sbjct: 1814 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1873
Query: 381 VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTL 440
D +R L+EQ Q KAD+E+ L R+ + ER++ L E+ TL
Sbjct: 1874 AEDEAFQRRRLEEQAAQH----------KADIEERLAQLRKASDSELERQKGLVED--TL 1921
Query: 441 TSKLQELQEM 450
+ Q +E+
Sbjct: 1922 RQRRQVEEEI 1931
Score = 40.8 bits (94), Expect = 0.004
Identities = 59/271 (21%), Positives = 107/271 (39%), Gaps = 37/271 (13%)
Query: 199 LKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGK 258
L R+ + +EK + L+ +++ E R + E ++Q L +++ + +
Sbjct: 1521 LASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579
Query: 259 KPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEW 318
L K+ L RS+QE L+E+ +R + Q E
Sbjct: 1580 AELQSKRAS------FAEKTAQLERSLQEEHVAVAQLREEAER---------RAQQQAEA 1624
Query: 319 SKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLR 378
+ R E E++L E + A E +R A + Q ++ K+
Sbjct: 1625 ERAR-----EEAEREL---ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1676
Query: 379 GAVRDLKEERTALQEQLLQRDLEVKQLL-----QAKADLEKELECAREGEEERREREEVL 433
R EE+ Q +L +++LE ++ L Q + E+EL R E+ ++ ++L
Sbjct: 1677 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1736
Query: 434 REEIQTL-------TSKLQELQ-EMKKEEKE 456
EE+ L T K QEL+ E+ K E
Sbjct: 1737 EEELARLQREAAAATQKRQELEAELAKVRAE 1767
Score = 39.7 bits (91), Expect = 0.009
Identities = 64/353 (18%), Positives = 137/353 (38%), Gaps = 32/353 (9%)
Query: 145 KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRI- 203
K +L + R+L E R+ R+ E+ + S + A +R A + LK ++
Sbjct: 1966 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVERLKAKVE 2023
Query: 204 --LKLEQQCKEKDGTISKLQTD--MKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKK 259
+L ++ +++ +L + K EE A +E LQ L ++ +
Sbjct: 2024 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQTLQQEQSVLDQ 2082
Query: 260 PLGEKKTGAKRQKKMGSALLSLSRS-------VQELTEENQSLKEDLDRVLSTSPTISKT 312
GE + + ++ A + R V+E QS +E K
Sbjct: 2083 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2142
Query: 313 QGYVEWSKPRLLR-RIVELEKKLSV---MESSKSHAAEPVRSHPPACLASSSALHRQPRG 368
+ E R + L +K + ME K A + +R ++ +
Sbjct: 2143 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2202
Query: 369 DRNK-----DHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE--------KE 415
D K + +RL+ + +R+ ++E+L +++++L + KA +E ++
Sbjct: 2203 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2262
Query: 416 LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
+ + +E E+ + + EE L+ QE +++ +ED + A+++
Sbjct: 2263 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2315
Score = 39.3 bits (90), Expect = 0.012
Identities = 60/262 (22%), Positives = 108/262 (41%), Gaps = 33/262 (12%)
Query: 230 EEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQ---------KKMGSALLS 280
EE R+A + EE RL + A+ E ++ L E AK Q ++M ++
Sbjct: 1350 EEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1407
Query: 281 LSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGY----VEWSKPRLLRRIVELEKKLSV 336
+ + ++ +S++E+L ++ +S + + E S+ R+ I + +L
Sbjct: 1408 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1467
Query: 337 MESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLL 396
E + A ++ A A + Q R ++ ERLR V+D + + + +L
Sbjct: 1468 TERQRGGAEGELQ----ALRARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELA 1522
Query: 397 QR-------DLEVKQLLQAKADLEKELECA----REGEEERREREEVLREEIQTLTSKLQ 445
R E ++ LQA +L + E A R+ E ER + +V E Q S
Sbjct: 1523 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEA 1580
Query: 446 ELQEMKKEEKEDCPEVPHKAQE 467
ELQ + E ++ QE
Sbjct: 1581 ELQSKRASFAEKTAQLERSLQE 1602
Score = 38.1 bits (87), Expect = 0.027
Identities = 82/418 (19%), Positives = 159/418 (38%), Gaps = 75/418 (17%)
Query: 118 VPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR 177
+ GT E ++E ++ +++ +++ + L++L + + + L D R
Sbjct: 1099 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1158
Query: 178 GTDFV-RTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAM 236
G V L ++ + + ++R+ +L ++ + QTD++ LE++ +
Sbjct: 1159 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV-----LAQTDVRQRELEQLGRQL 1213
Query: 237 ETYYEEVHRLQTLLASS----ETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEEN 292
Y E L L + E PL + + + Q + ALL E EE
Sbjct: 1214 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQA-VREQLRQEQALLEEIERHGEKVEEC 1272
Query: 293 Q------------------SLKEDLDRVLST-------SPTISKTQGYVE----WSKPRL 323
Q + K L+ V S S + S Q YV+ +S+
Sbjct: 1273 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1332
Query: 324 L--RRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAV 381
L + I + + L ME + AE R+ LA A + R + A
Sbjct: 1333 LTSQYIKFISETLRRMEEEE-RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1391
Query: 382 RDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEE----------ERRER-- 429
R+ KE + +QE++++R+ Q K +++EL+ R+ E E ER
Sbjct: 1392 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1451
Query: 430 ---EEVLRE-----------------EIQTLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
EE +R E+Q L ++ +E + K++ +E+ + + Q+
Sbjct: 1452 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1509
Score = 36.6 bits (83), Expect = 0.078
Identities = 51/260 (19%), Positives = 97/260 (37%), Gaps = 40/260 (15%)
Query: 201 QRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKP 260
QR + E Q K Q + +L+E +A+ EE R A + ++
Sbjct: 1575 QRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR----AQQQAEAERA 1627
Query: 261 LGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSK 320
E + +R + + L L +E+ ++ + + ++ + ++ +G E
Sbjct: 1628 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1687
Query: 321 PRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGA 380
R +++L+ E K LA +A Q R ++ RLR
Sbjct: 1688 VR--------QRELAEQELEKQRQ-----------LAEGTA---QQRLAAEQELIRLRAE 1725
Query: 381 VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR-----------EGEEERRER 429
+++R L+E+L + E Q + +LE EL R EEE R
Sbjct: 1726 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1785
Query: 430 EEVLREEIQTLTSKLQELQE 449
E ++ ++ + +EL E
Sbjct: 1786 SEKSKQRLEAEAGRFRELAE 1805
Score = 32.3 bits (72), Expect = 1.5
Identities = 31/180 (17%), Positives = 73/180 (40%), Gaps = 11/180 (6%)
Query: 281 LSRSVQELTEEN----QSLKEDLDRVLSTSPTISKTQGYVE---WSKPRLLRRIVELEKK 333
+S +++ + EE Q E+ +R+ + K + E +K + R EL+++
Sbjct: 1341 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1400
Query: 334 LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
+ + AA + + L + + + A R R ++E
Sbjct: 1401 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS----RLRIEE 1456
Query: 394 QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
++ L+++ + + E EL+ R EE ++ +EE + L ++Q+ + K++
Sbjct: 1457 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1516
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 58.9 bits (141), Expect = 1e-08
Identities = 69/347 (19%), Positives = 147/347 (42%), Gaps = 27/347 (7%)
Query: 125 REKEDMYDEIIELKKSLH---VQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF 181
R++ + +EI+ LK S K++++L ++R E+ R Q E L+ +R
Sbjct: 1918 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAARQRQL 1975
Query: 182 VRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
+R +A + Q+ L E++ + + LEE+ ++ E
Sbjct: 1976 AAEEERRRREAEERV----QKSLAAEEEAARQ-----------RKAALEEVE-RLKAKVE 2019
Query: 242 EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDR 301
E RL+ A E+ + L ++ + Q + + ++ + QEL + Q + LD+
Sbjct: 2020 EARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078
Query: 302 VLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
+ + + E ++ + R + +++ E K A E ++ A + A
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-----AQAQA 2133
Query: 362 LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
+ R + ++ R A + ++ A ++ + +Q L+ KA +E+EL R
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2193
Query: 422 GEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
EE ++ +L EE+Q L ++ E + + +E+ V + +EL
Sbjct: 2194 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2240
Score = 57.8 bits (138), Expect = 3e-08
Identities = 80/384 (20%), Positives = 161/384 (41%), Gaps = 60/384 (15%)
Query: 125 REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
+EK E LK + + +L + + RRL+E+ K++ +QL + ++G F RT
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQG--FQRT 2367
Query: 185 LAEKRPDASWVINGLKQRILKLE---QQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
L +R QR L++ ++ K + +S+ Q + + + R E E
Sbjct: 2368 LEAER-----------QRQLEMSAEAERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGE 2415
Query: 242 EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQ--SLKEDL 299
++HR + T + +++ +++ A+ L R ++L +E + LK +
Sbjct: 2416 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2475
Query: 300 DRVLSTSPTISKTQGYVEW---SKPRLLRR--IVELEK-KLSVMESSKSHAAEPVRSHPP 353
+ + + +TQ + K LL+R +E EK KL + + A+ +R
Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-- 2533
Query: 354 ACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE 413
++ + ++ +RL ++ + + + +E + ++ E++QL
Sbjct: 2534 ---------QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL-------- 2576
Query: 414 KELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTP 473
E++RR++EE+L EE Q L +LQ L+E + EV P
Sbjct: 2577 ---------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2627
Query: 474 SSRHC----EQDWPPDSSEEGLPR 493
+ R + P+ S +GL R
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRR 2651
Score = 50.4 bits (119), Expect = 5e-06
Identities = 82/370 (22%), Positives = 162/370 (43%), Gaps = 46/370 (12%)
Query: 101 TFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLR---- 156
+F K L RS HV + E E + E +++ + +++ + K
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643
Query: 157 -RLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRIL---KLEQQCKE 212
RL+ E + + + Q + + + A +R A ++QR L +LE+Q +
Sbjct: 1644 LRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQL 1700
Query: 213 KDGTISK--------LQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEK 264
+GT + ++ +T E+ R +E EE+ RLQ A++ T K+ E
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE---EELARLQREAAAA--TQKRQELEA 1755
Query: 265 KTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLL 324
+ AK + +M L S +R+ +E ++ K+ L+ +++ E ++ R L
Sbjct: 1756 EL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRAL 1809
Query: 325 RRIVELEKKLSVMESSKSHA-AEPVRSHPPACLASSSALHRQPR---GDRNKDHERLRGA 380
+ +++L+ ++++ A AE V + A + ++ L + ++ ++ERLR
Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869
Query: 381 VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTL 440
D +R L+EQ Q KAD+E+ L R+ + ER++ L E+ TL
Sbjct: 1870 AEDEAFQRRRLEEQAAQH----------KADIEERLAQLRKASDSELERQKGLVED--TL 1917
Query: 441 TSKLQELQEM 450
+ Q +E+
Sbjct: 1918 RQRRQVEEEI 1927
Score = 40.8 bits (94), Expect = 0.004
Identities = 59/271 (21%), Positives = 107/271 (39%), Gaps = 37/271 (13%)
Query: 199 LKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGK 258
L R+ + +EK + L+ +++ E R + E ++Q L +++ + +
Sbjct: 1517 LASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 259 KPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEW 318
L K+ L RS+QE L+E+ +R + Q E
Sbjct: 1576 AELQSKRAS------FAEKTAQLERSLQEEHVAVAQLREEAER---------RAQQQAEA 1620
Query: 319 SKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLR 378
+ R E E++L E + A E +R A + Q ++ K+
Sbjct: 1621 ERAR-----EEAEREL---ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1672
Query: 379 GAVRDLKEERTALQEQLLQRDLEVKQLL-----QAKADLEKELECAREGEEERREREEVL 433
R EE+ Q +L +++LE ++ L Q + E+EL R E+ ++ ++L
Sbjct: 1673 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1732
Query: 434 REEIQTL-------TSKLQELQ-EMKKEEKE 456
EE+ L T K QEL+ E+ K E
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAE 1763
Score = 39.7 bits (91), Expect = 0.009
Identities = 64/353 (18%), Positives = 137/353 (38%), Gaps = 32/353 (9%)
Query: 145 KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRI- 203
K +L + R+L E R+ R+ E+ + S + A +R A + LK ++
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVERLKAKVE 2019
Query: 204 --LKLEQQCKEKDGTISKLQTD--MKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKK 259
+L ++ +++ +L + K EE A +E LQ L ++ +
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQTLQQEQSVLDQ 2078
Query: 260 PLGEKKTGAKRQKKMGSALLSLSRS-------VQELTEENQSLKEDLDRVLSTSPTISKT 312
GE + + ++ A + R V+E QS +E K
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2138
Query: 313 QGYVEWSKPRLLR-RIVELEKKLSV---MESSKSHAAEPVRSHPPACLASSSALHRQPRG 368
+ E R + L +K + ME K A + +R ++ +
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198
Query: 369 DRNK-----DHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE--------KE 415
D K + +RL+ + +R+ ++E+L +++++L + KA +E ++
Sbjct: 2199 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2258
Query: 416 LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
+ + +E E+ + + EE L+ QE +++ +ED + A+++
Sbjct: 2259 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311
Score = 39.3 bits (90), Expect = 0.012
Identities = 60/262 (22%), Positives = 108/262 (41%), Gaps = 33/262 (12%)
Query: 230 EEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQ---------KKMGSALLS 280
EE R+A + EE RL + A+ E ++ L E AK Q ++M ++
Sbjct: 1346 EEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 281 LSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGY----VEWSKPRLLRRIVELEKKLSV 336
+ + ++ +S++E+L ++ +S + + E S+ R+ I + +L
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1463
Query: 337 MESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLL 396
E + A ++ A A + Q R ++ ERLR V+D + + + +L
Sbjct: 1464 TERQRGGAEGELQ----ALRARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELA 1518
Query: 397 QR-------DLEVKQLLQAKADLEKELECA----REGEEERREREEVLREEIQTLTSKLQ 445
R E ++ LQA +L + E A R+ E ER + +V E Q S
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEA 1576
Query: 446 ELQEMKKEEKEDCPEVPHKAQE 467
ELQ + E ++ QE
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQE 1598
Score = 38.1 bits (87), Expect = 0.027
Identities = 82/418 (19%), Positives = 159/418 (38%), Gaps = 75/418 (17%)
Query: 118 VPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR 177
+ GT E ++E ++ +++ +++ + L++L + + + L D R
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1154
Query: 178 GTDFV-RTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAM 236
G V L ++ + + ++R+ +L ++ + QTD++ LE++ +
Sbjct: 1155 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV-----LAQTDVRQRELEQLGRQL 1209
Query: 237 ETYYEEVHRLQTLLASS----ETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEEN 292
Y E L L + E PL + + + Q + ALL E EE
Sbjct: 1210 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQA-VREQLRQEQALLEEIERHGEKVEEC 1268
Query: 293 Q------------------SLKEDLDRVLST-------SPTISKTQGYVE----WSKPRL 323
Q + K L+ V S S + S Q YV+ +S+
Sbjct: 1269 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1328
Query: 324 L--RRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAV 381
L + I + + L ME + AE R+ LA A + R + A
Sbjct: 1329 LTSQYIKFISETLRRMEEEE-RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1387
Query: 382 RDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEE----------ERRER-- 429
R+ KE + +QE++++R+ Q K +++EL+ R+ E E ER
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 430 ---EEVLRE-----------------EIQTLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
EE +R E+Q L ++ +E + K++ +E+ + + Q+
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1505
Score = 36.6 bits (83), Expect = 0.078
Identities = 51/260 (19%), Positives = 97/260 (37%), Gaps = 40/260 (15%)
Query: 201 QRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKP 260
QR + E Q K Q + +L+E +A+ EE R A + ++
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR----AQQQAEAERA 1623
Query: 261 LGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSK 320
E + +R + + L L +E+ ++ + + ++ + ++ +G E
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 321 PRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGA 380
R +++L+ E K LA +A Q R ++ RLR
Sbjct: 1684 VR--------QRELAEQELEKQRQ-----------LAEGTA---QQRLAAEQELIRLRAE 1721
Query: 381 VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR-----------EGEEERRER 429
+++R L+E+L + E Q + +LE EL R EEE R
Sbjct: 1722 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1781
Query: 430 EEVLREEIQTLTSKLQELQE 449
E ++ ++ + +EL E
Sbjct: 1782 SEKSKQRLEAEAGRFRELAE 1801
Score = 32.3 bits (72), Expect = 1.5
Identities = 31/180 (17%), Positives = 73/180 (40%), Gaps = 11/180 (6%)
Query: 281 LSRSVQELTEEN----QSLKEDLDRVLSTSPTISKTQGYVE---WSKPRLLRRIVELEKK 333
+S +++ + EE Q E+ +R+ + K + E +K + R EL+++
Sbjct: 1337 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1396
Query: 334 LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
+ + AA + + L + + + A R R ++E
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS----RLRIEE 1452
Query: 394 QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
++ L+++ + + E EL+ R EE ++ +EE + L ++Q+ + K++
Sbjct: 1453 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 58.9 bits (141), Expect = 1e-08
Identities = 69/347 (19%), Positives = 147/347 (42%), Gaps = 27/347 (7%)
Query: 125 REKEDMYDEIIELKKSLH---VQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF 181
R++ + +EI+ LK S K++++L ++R E+ R Q E L+ +R
Sbjct: 1886 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAARQRQL 1943
Query: 182 VRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
+R +A + Q+ L E++ + + LEE+ ++ E
Sbjct: 1944 AAEEERRRREAEERV----QKSLAAEEEAARQ-----------RKAALEEVE-RLKAKVE 1987
Query: 242 EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDR 301
E RL+ A E+ + L ++ + Q + + ++ + QEL + Q + LD+
Sbjct: 1988 EARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2046
Query: 302 VLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
+ + + E ++ + R + +++ E K A E ++ A + A
Sbjct: 2047 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-----AQAQA 2101
Query: 362 LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
+ R + ++ R A + ++ A ++ + +Q L+ KA +E+EL R
Sbjct: 2102 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2161
Query: 422 GEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
EE ++ +L EE+Q L ++ E + + +E+ V + +EL
Sbjct: 2162 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2208
Score = 57.8 bits (138), Expect = 3e-08
Identities = 80/384 (20%), Positives = 161/384 (41%), Gaps = 60/384 (15%)
Query: 125 REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
+EK E LK + + +L + + RRL+E+ K++ +QL + ++G F RT
Sbjct: 2281 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQG--FQRT 2335
Query: 185 LAEKRPDASWVINGLKQRILKLE---QQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
L +R QR L++ ++ K + +S+ Q + + + R E E
Sbjct: 2336 LEAER-----------QRQLEMSAEAERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGE 2383
Query: 242 EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQ--SLKEDL 299
++HR + T + +++ +++ A+ L R ++L +E + LK +
Sbjct: 2384 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2443
Query: 300 DRVLSTSPTISKTQGYVEW---SKPRLLRR--IVELEK-KLSVMESSKSHAAEPVRSHPP 353
+ + + +TQ + K LL+R +E EK KL + + A+ +R
Sbjct: 2444 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-- 2501
Query: 354 ACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE 413
++ + ++ +RL ++ + + + +E + ++ E++QL
Sbjct: 2502 ---------QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL-------- 2544
Query: 414 KELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTP 473
E++RR++EE+L EE Q L +LQ L+E + EV P
Sbjct: 2545 ---------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2595
Query: 474 SSRHC----EQDWPPDSSEEGLPR 493
+ R + P+ S +GL R
Sbjct: 2596 NGRDALDGPAAEAEPEHSFDGLRR 2619
Score = 50.4 bits (119), Expect = 5e-06
Identities = 82/370 (22%), Positives = 162/370 (43%), Gaps = 46/370 (12%)
Query: 101 TFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLR---- 156
+F K L RS HV + E E + E +++ + +++ + K
Sbjct: 1552 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1611
Query: 157 -RLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRIL---KLEQQCKE 212
RL+ E + + + Q + + + A +R A ++QR L +LE+Q +
Sbjct: 1612 LRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQL 1668
Query: 213 KDGTISK--------LQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEK 264
+GT + ++ +T E+ R +E EE+ RLQ A++ T K+ E
Sbjct: 1669 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE---EELARLQREAAAA--TQKRQELEA 1723
Query: 265 KTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLL 324
+ AK + +M L S +R+ +E ++ K+ L+ +++ E ++ R L
Sbjct: 1724 EL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRAL 1777
Query: 325 RRIVELEKKLSVMESSKSHA-AEPVRSHPPACLASSSALHRQPR---GDRNKDHERLRGA 380
+ +++L+ ++++ A AE V + A + ++ L + ++ ++ERLR
Sbjct: 1778 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1837
Query: 381 VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTL 440
D +R L+EQ Q KAD+E+ L R+ + ER++ L E+ TL
Sbjct: 1838 AEDEAFQRRRLEEQAAQH----------KADIEERLAQLRKASDSELERQKGLVED--TL 1885
Query: 441 TSKLQELQEM 450
+ Q +E+
Sbjct: 1886 RQRRQVEEEI 1895
Score = 40.8 bits (94), Expect = 0.004
Identities = 59/271 (21%), Positives = 107/271 (39%), Gaps = 37/271 (13%)
Query: 199 LKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGK 258
L R+ + +EK + L+ +++ E R + E ++Q L +++ + +
Sbjct: 1485 LASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543
Query: 259 KPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEW 318
L K+ L RS+QE L+E+ +R + Q E
Sbjct: 1544 AELQSKRAS------FAEKTAQLERSLQEEHVAVAQLREEAER---------RAQQQAEA 1588
Query: 319 SKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLR 378
+ R E E++L E + A E +R A + Q ++ K+
Sbjct: 1589 ERAR-----EEAEREL---ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1640
Query: 379 GAVRDLKEERTALQEQLLQRDLEVKQLL-----QAKADLEKELECAREGEEERREREEVL 433
R EE+ Q +L +++LE ++ L Q + E+EL R E+ ++ ++L
Sbjct: 1641 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1700
Query: 434 REEIQTL-------TSKLQELQ-EMKKEEKE 456
EE+ L T K QEL+ E+ K E
Sbjct: 1701 EEELARLQREAAAATQKRQELEAELAKVRAE 1731
Score = 39.7 bits (91), Expect = 0.009
Identities = 64/353 (18%), Positives = 137/353 (38%), Gaps = 32/353 (9%)
Query: 145 KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRI- 203
K +L + R+L E R+ R+ E+ + S + A +R A + LK ++
Sbjct: 1930 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVERLKAKVE 1987
Query: 204 --LKLEQQCKEKDGTISKLQTD--MKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKK 259
+L ++ +++ +L + K EE A +E LQ L ++ +
Sbjct: 1988 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQTLQQEQSVLDQ 2046
Query: 260 PLGEKKTGAKRQKKMGSALLSLSRS-------VQELTEENQSLKEDLDRVLSTSPTISKT 312
GE + + ++ A + R V+E QS +E K
Sbjct: 2047 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2106
Query: 313 QGYVEWSKPRLLR-RIVELEKKLSV---MESSKSHAAEPVRSHPPACLASSSALHRQPRG 368
+ E R + L +K + ME K A + +R ++ +
Sbjct: 2107 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2166
Query: 369 DRNK-----DHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE--------KE 415
D K + +RL+ + +R+ ++E+L +++++L + KA +E ++
Sbjct: 2167 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2226
Query: 416 LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
+ + +E E+ + + EE L+ QE +++ +ED + A+++
Sbjct: 2227 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2279
Score = 39.3 bits (90), Expect = 0.012
Identities = 60/262 (22%), Positives = 108/262 (41%), Gaps = 33/262 (12%)
Query: 230 EEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQ---------KKMGSALLS 280
EE R+A + EE RL + A+ E ++ L E AK Q ++M ++
Sbjct: 1314 EEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1371
Query: 281 LSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGY----VEWSKPRLLRRIVELEKKLSV 336
+ + ++ +S++E+L ++ +S + + E S+ R+ I + +L
Sbjct: 1372 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1431
Query: 337 MESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLL 396
E + A ++ A A + Q R ++ ERLR V+D + + + +L
Sbjct: 1432 TERQRGGAEGELQ----ALRARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELA 1486
Query: 397 QR-------DLEVKQLLQAKADLEKELECA----REGEEERREREEVLREEIQTLTSKLQ 445
R E ++ LQA +L + E A R+ E ER + +V E Q S
Sbjct: 1487 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEA 1544
Query: 446 ELQEMKKEEKEDCPEVPHKAQE 467
ELQ + E ++ QE
Sbjct: 1545 ELQSKRASFAEKTAQLERSLQE 1566
Score = 38.1 bits (87), Expect = 0.027
Identities = 82/418 (19%), Positives = 159/418 (38%), Gaps = 75/418 (17%)
Query: 118 VPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR 177
+ GT E ++E ++ +++ +++ + L++L + + + L D R
Sbjct: 1063 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1122
Query: 178 GTDFV-RTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAM 236
G V L ++ + + ++R+ +L ++ + QTD++ LE++ +
Sbjct: 1123 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV-----LAQTDVRQRELEQLGRQL 1177
Query: 237 ETYYEEVHRLQTLLASS----ETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEEN 292
Y E L L + E PL + + + Q + ALL E EE
Sbjct: 1178 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQA-VREQLRQEQALLEEIERHGEKVEEC 1236
Query: 293 Q------------------SLKEDLDRVLST-------SPTISKTQGYVE----WSKPRL 323
Q + K L+ V S S + S Q YV+ +S+
Sbjct: 1237 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1296
Query: 324 L--RRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAV 381
L + I + + L ME + AE R+ LA A + R + A
Sbjct: 1297 LTSQYIKFISETLRRMEEEE-RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1355
Query: 382 RDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEE----------ERRER-- 429
R+ KE + +QE++++R+ Q K +++EL+ R+ E E ER
Sbjct: 1356 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1415
Query: 430 ---EEVLRE-----------------EIQTLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
EE +R E+Q L ++ +E + K++ +E+ + + Q+
Sbjct: 1416 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1473
Score = 36.6 bits (83), Expect = 0.078
Identities = 51/260 (19%), Positives = 97/260 (37%), Gaps = 40/260 (15%)
Query: 201 QRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKP 260
QR + E Q K Q + +L+E +A+ EE R A + ++
Sbjct: 1539 QRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR----AQQQAEAERA 1591
Query: 261 LGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSK 320
E + +R + + L L +E+ ++ + + ++ + ++ +G E
Sbjct: 1592 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1651
Query: 321 PRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGA 380
R +++L+ E K LA +A Q R ++ RLR
Sbjct: 1652 VR--------QRELAEQELEKQRQ-----------LAEGTA---QQRLAAEQELIRLRAE 1689
Query: 381 VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR-----------EGEEERRER 429
+++R L+E+L + E Q + +LE EL R EEE R
Sbjct: 1690 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1749
Query: 430 EEVLREEIQTLTSKLQELQE 449
E ++ ++ + +EL E
Sbjct: 1750 SEKSKQRLEAEAGRFRELAE 1769
Score = 32.3 bits (72), Expect = 1.5
Identities = 31/180 (17%), Positives = 73/180 (40%), Gaps = 11/180 (6%)
Query: 281 LSRSVQELTEEN----QSLKEDLDRVLSTSPTISKTQGYVE---WSKPRLLRRIVELEKK 333
+S +++ + EE Q E+ +R+ + K + E +K + R EL+++
Sbjct: 1305 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1364
Query: 334 LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
+ + AA + + L + + + A R R ++E
Sbjct: 1365 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS----RLRIEE 1420
Query: 394 QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
++ L+++ + + E EL+ R EE ++ +EE + L ++Q+ + K++
Sbjct: 1421 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1480
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 58.9 bits (141), Expect = 1e-08
Identities = 69/347 (19%), Positives = 147/347 (42%), Gaps = 27/347 (7%)
Query: 125 REKEDMYDEIIELKKSLH---VQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF 181
R++ + +EI+ LK S K++++L ++R E+ R Q E L+ +R
Sbjct: 2055 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAARQRQL 2112
Query: 182 VRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
+R +A + Q+ L E++ + + LEE+ ++ E
Sbjct: 2113 AAEEERRRREAEERV----QKSLAAEEEAARQ-----------RKAALEEVE-RLKAKVE 2156
Query: 242 EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDR 301
E RL+ A E+ + L ++ + Q + + ++ + QEL + Q + LD+
Sbjct: 2157 EARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2215
Query: 302 VLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
+ + + E ++ + R + +++ E K A E ++ A + A
Sbjct: 2216 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-----AQAQA 2270
Query: 362 LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
+ R + ++ R A + ++ A ++ + +Q L+ KA +E+EL R
Sbjct: 2271 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2330
Query: 422 GEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
EE ++ +L EE+Q L ++ E + + +E+ V + +EL
Sbjct: 2331 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2377
Score = 57.8 bits (138), Expect = 3e-08
Identities = 80/384 (20%), Positives = 161/384 (41%), Gaps = 60/384 (15%)
Query: 125 REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
+EK E LK + + +L + + RRL+E+ K++ +QL + ++G F RT
Sbjct: 2450 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQG--FQRT 2504
Query: 185 LAEKRPDASWVINGLKQRILKLE---QQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
L +R QR L++ ++ K + +S+ Q + + + R E E
Sbjct: 2505 LEAER-----------QRQLEMSAEAERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGE 2552
Query: 242 EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQ--SLKEDL 299
++HR + T + +++ +++ A+ L R ++L +E + LK +
Sbjct: 2553 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2612
Query: 300 DRVLSTSPTISKTQGYVEW---SKPRLLRR--IVELEK-KLSVMESSKSHAAEPVRSHPP 353
+ + + +TQ + K LL+R +E EK KL + + A+ +R
Sbjct: 2613 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-- 2670
Query: 354 ACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE 413
++ + ++ +RL ++ + + + +E + ++ E++QL
Sbjct: 2671 ---------QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL-------- 2713
Query: 414 KELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTP 473
E++RR++EE+L EE Q L +LQ L+E + EV P
Sbjct: 2714 ---------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2764
Query: 474 SSRHC----EQDWPPDSSEEGLPR 493
+ R + P+ S +GL R
Sbjct: 2765 NGRDALDGPAAEAEPEHSFDGLRR 2788
Score = 50.4 bits (119), Expect = 5e-06
Identities = 82/370 (22%), Positives = 162/370 (43%), Gaps = 46/370 (12%)
Query: 101 TFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLR---- 156
+F K L RS HV + E E + E +++ + +++ + K
Sbjct: 1721 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1780
Query: 157 -RLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRIL---KLEQQCKE 212
RL+ E + + + Q + + + A +R A ++QR L +LE+Q +
Sbjct: 1781 LRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQL 1837
Query: 213 KDGTISK--------LQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEK 264
+GT + ++ +T E+ R +E EE+ RLQ A++ T K+ E
Sbjct: 1838 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE---EELARLQREAAAA--TQKRQELEA 1892
Query: 265 KTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLL 324
+ AK + +M L S +R+ +E ++ K+ L+ +++ E ++ R L
Sbjct: 1893 EL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRAL 1946
Query: 325 RRIVELEKKLSVMESSKSHA-AEPVRSHPPACLASSSALHRQPR---GDRNKDHERLRGA 380
+ +++L+ ++++ A AE V + A + ++ L + ++ ++ERLR
Sbjct: 1947 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 2006
Query: 381 VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTL 440
D +R L+EQ Q KAD+E+ L R+ + ER++ L E+ TL
Sbjct: 2007 AEDEAFQRRRLEEQAAQH----------KADIEERLAQLRKASDSELERQKGLVED--TL 2054
Query: 441 TSKLQELQEM 450
+ Q +E+
Sbjct: 2055 RQRRQVEEEI 2064
Score = 40.8 bits (94), Expect = 0.004
Identities = 59/271 (21%), Positives = 107/271 (39%), Gaps = 37/271 (13%)
Query: 199 LKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGK 258
L R+ + +EK + L+ +++ E R + E ++Q L +++ + +
Sbjct: 1654 LASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712
Query: 259 KPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEW 318
L K+ L RS+QE L+E+ +R + Q E
Sbjct: 1713 AELQSKRAS------FAEKTAQLERSLQEEHVAVAQLREEAER---------RAQQQAEA 1757
Query: 319 SKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLR 378
+ R E E++L E + A E +R A + Q ++ K+
Sbjct: 1758 ERAR-----EEAEREL---ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1809
Query: 379 GAVRDLKEERTALQEQLLQRDLEVKQLL-----QAKADLEKELECAREGEEERREREEVL 433
R EE+ Q +L +++LE ++ L Q + E+EL R E+ ++ ++L
Sbjct: 1810 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1869
Query: 434 REEIQTL-------TSKLQELQ-EMKKEEKE 456
EE+ L T K QEL+ E+ K E
Sbjct: 1870 EEELARLQREAAAATQKRQELEAELAKVRAE 1900
Score = 39.7 bits (91), Expect = 0.009
Identities = 64/353 (18%), Positives = 137/353 (38%), Gaps = 32/353 (9%)
Query: 145 KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRI- 203
K +L + R+L E R+ R+ E+ + S + A +R A + LK ++
Sbjct: 2099 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVERLKAKVE 2156
Query: 204 --LKLEQQCKEKDGTISKLQTD--MKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKK 259
+L ++ +++ +L + K EE A +E LQ L ++ +
Sbjct: 2157 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQTLQQEQSVLDQ 2215
Query: 260 PLGEKKTGAKRQKKMGSALLSLSRS-------VQELTEENQSLKEDLDRVLSTSPTISKT 312
GE + + ++ A + R V+E QS +E K
Sbjct: 2216 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2275
Query: 313 QGYVEWSKPRLLR-RIVELEKKLSV---MESSKSHAAEPVRSHPPACLASSSALHRQPRG 368
+ E R + L +K + ME K A + +R ++ +
Sbjct: 2276 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2335
Query: 369 DRNK-----DHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE--------KE 415
D K + +RL+ + +R+ ++E+L +++++L + KA +E ++
Sbjct: 2336 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2395
Query: 416 LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
+ + +E E+ + + EE L+ QE +++ +ED + A+++
Sbjct: 2396 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2448
Score = 39.3 bits (90), Expect = 0.012
Identities = 60/262 (22%), Positives = 108/262 (41%), Gaps = 33/262 (12%)
Query: 230 EEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQ---------KKMGSALLS 280
EE R+A + EE RL + A+ E ++ L E AK Q ++M ++
Sbjct: 1483 EEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540
Query: 281 LSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGY----VEWSKPRLLRRIVELEKKLSV 336
+ + ++ +S++E+L ++ +S + + E S+ R+ I + +L
Sbjct: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1600
Query: 337 MESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLL 396
E + A ++ A A + Q R ++ ERLR V+D + + + +L
Sbjct: 1601 TERQRGGAEGELQ----ALRARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELA 1655
Query: 397 QR-------DLEVKQLLQAKADLEKELECA----REGEEERREREEVLREEIQTLTSKLQ 445
R E ++ LQA +L + E A R+ E ER + +V E Q S
Sbjct: 1656 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEA 1713
Query: 446 ELQEMKKEEKEDCPEVPHKAQE 467
ELQ + E ++ QE
Sbjct: 1714 ELQSKRASFAEKTAQLERSLQE 1735
Score = 38.1 bits (87), Expect = 0.027
Identities = 82/418 (19%), Positives = 159/418 (38%), Gaps = 75/418 (17%)
Query: 118 VPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR 177
+ GT E ++E ++ +++ +++ + L++L + + + L D R
Sbjct: 1232 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1291
Query: 178 GTDFV-RTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAM 236
G V L ++ + + ++R+ +L ++ + QTD++ LE++ +
Sbjct: 1292 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV-----LAQTDVRQRELEQLGRQL 1346
Query: 237 ETYYEEVHRLQTLLASS----ETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEEN 292
Y E L L + E PL + + + Q + ALL E EE
Sbjct: 1347 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQA-VREQLRQEQALLEEIERHGEKVEEC 1405
Query: 293 Q------------------SLKEDLDRVLST-------SPTISKTQGYVE----WSKPRL 323
Q + K L+ V S S + S Q YV+ +S+
Sbjct: 1406 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1465
Query: 324 L--RRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAV 381
L + I + + L ME + AE R+ LA A + R + A
Sbjct: 1466 LTSQYIKFISETLRRMEEEE-RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1524
Query: 382 RDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEE----------ERRER-- 429
R+ KE + +QE++++R+ Q K +++EL+ R+ E E ER
Sbjct: 1525 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1584
Query: 430 ---EEVLRE-----------------EIQTLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
EE +R E+Q L ++ +E + K++ +E+ + + Q+
Sbjct: 1585 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1642
Score = 36.6 bits (83), Expect = 0.078
Identities = 51/260 (19%), Positives = 97/260 (37%), Gaps = 40/260 (15%)
Query: 201 QRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKP 260
QR + E Q K Q + +L+E +A+ EE R A + ++
Sbjct: 1708 QRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR----AQQQAEAERA 1760
Query: 261 LGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSK 320
E + +R + + L L +E+ ++ + + ++ + ++ +G E
Sbjct: 1761 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1820
Query: 321 PRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGA 380
R +++L+ E K LA +A Q R ++ RLR
Sbjct: 1821 VR--------QRELAEQELEKQRQ-----------LAEGTA---QQRLAAEQELIRLRAE 1858
Query: 381 VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR-----------EGEEERRER 429
+++R L+E+L + E Q + +LE EL R EEE R
Sbjct: 1859 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1918
Query: 430 EEVLREEIQTLTSKLQELQE 449
E ++ ++ + +EL E
Sbjct: 1919 SEKSKQRLEAEAGRFRELAE 1938
Score = 32.3 bits (72), Expect = 1.5
Identities = 31/180 (17%), Positives = 73/180 (40%), Gaps = 11/180 (6%)
Query: 281 LSRSVQELTEEN----QSLKEDLDRVLSTSPTISKTQGYVE---WSKPRLLRRIVELEKK 333
+S +++ + EE Q E+ +R+ + K + E +K + R EL+++
Sbjct: 1474 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1533
Query: 334 LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
+ + AA + + L + + + A R R ++E
Sbjct: 1534 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS----RLRIEE 1589
Query: 394 QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
++ L+++ + + E EL+ R EE ++ +EE + L ++Q+ + K++
Sbjct: 1590 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1649
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 58.9 bits (141), Expect = 1e-08
Identities = 69/347 (19%), Positives = 147/347 (42%), Gaps = 27/347 (7%)
Query: 125 REKEDMYDEIIELKKSLH---VQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF 181
R++ + +EI+ LK S K++++L ++R E+ R Q E L+ +R
Sbjct: 1896 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAARQRQL 1953
Query: 182 VRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
+R +A + Q+ L E++ + + LEE+ ++ E
Sbjct: 1954 AAEEERRRREAEERV----QKSLAAEEEAARQ-----------RKAALEEVE-RLKAKVE 1997
Query: 242 EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDR 301
E RL+ A E+ + L ++ + Q + + ++ + QEL + Q + LD+
Sbjct: 1998 EARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2056
Query: 302 VLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
+ + + E ++ + R + +++ E K A E ++ A + A
Sbjct: 2057 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-----AQAQA 2111
Query: 362 LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
+ R + ++ R A + ++ A ++ + +Q L+ KA +E+EL R
Sbjct: 2112 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2171
Query: 422 GEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
EE ++ +L EE+Q L ++ E + + +E+ V + +EL
Sbjct: 2172 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2218
Score = 57.8 bits (138), Expect = 3e-08
Identities = 80/384 (20%), Positives = 161/384 (41%), Gaps = 60/384 (15%)
Query: 125 REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
+EK E LK + + +L + + RRL+E+ K++ +QL + ++G F RT
Sbjct: 2291 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQG--FQRT 2345
Query: 185 LAEKRPDASWVINGLKQRILKLE---QQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
L +R QR L++ ++ K + +S+ Q + + + R E E
Sbjct: 2346 LEAER-----------QRQLEMSAEAERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGE 2393
Query: 242 EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQ--SLKEDL 299
++HR + T + +++ +++ A+ L R ++L +E + LK +
Sbjct: 2394 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2453
Query: 300 DRVLSTSPTISKTQGYVEW---SKPRLLRR--IVELEK-KLSVMESSKSHAAEPVRSHPP 353
+ + + +TQ + K LL+R +E EK KL + + A+ +R
Sbjct: 2454 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-- 2511
Query: 354 ACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE 413
++ + ++ +RL ++ + + + +E + ++ E++QL
Sbjct: 2512 ---------QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL-------- 2554
Query: 414 KELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTP 473
E++RR++EE+L EE Q L +LQ L+E + EV P
Sbjct: 2555 ---------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2605
Query: 474 SSRHC----EQDWPPDSSEEGLPR 493
+ R + P+ S +GL R
Sbjct: 2606 NGRDALDGPAAEAEPEHSFDGLRR 2629
Score = 50.4 bits (119), Expect = 5e-06
Identities = 82/370 (22%), Positives = 162/370 (43%), Gaps = 46/370 (12%)
Query: 101 TFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLR---- 156
+F K L RS HV + E E + E +++ + +++ + K
Sbjct: 1562 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1621
Query: 157 -RLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRIL---KLEQQCKE 212
RL+ E + + + Q + + + A +R A ++QR L +LE+Q +
Sbjct: 1622 LRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQL 1678
Query: 213 KDGTISK--------LQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEK 264
+GT + ++ +T E+ R +E EE+ RLQ A++ T K+ E
Sbjct: 1679 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE---EELARLQREAAAA--TQKRQELEA 1733
Query: 265 KTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLL 324
+ AK + +M L S +R+ +E ++ K+ L+ +++ E ++ R L
Sbjct: 1734 EL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRAL 1787
Query: 325 RRIVELEKKLSVMESSKSHA-AEPVRSHPPACLASSSALHRQPR---GDRNKDHERLRGA 380
+ +++L+ ++++ A AE V + A + ++ L + ++ ++ERLR
Sbjct: 1788 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1847
Query: 381 VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTL 440
D +R L+EQ Q KAD+E+ L R+ + ER++ L E+ TL
Sbjct: 1848 AEDEAFQRRRLEEQAAQH----------KADIEERLAQLRKASDSELERQKGLVED--TL 1895
Query: 441 TSKLQELQEM 450
+ Q +E+
Sbjct: 1896 RQRRQVEEEI 1905
Score = 40.8 bits (94), Expect = 0.004
Identities = 59/271 (21%), Positives = 107/271 (39%), Gaps = 37/271 (13%)
Query: 199 LKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGK 258
L R+ + +EK + L+ +++ E R + E ++Q L +++ + +
Sbjct: 1495 LASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553
Query: 259 KPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEW 318
L K+ L RS+QE L+E+ +R + Q E
Sbjct: 1554 AELQSKRAS------FAEKTAQLERSLQEEHVAVAQLREEAER---------RAQQQAEA 1598
Query: 319 SKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLR 378
+ R E E++L E + A E +R A + Q ++ K+
Sbjct: 1599 ERAR-----EEAEREL---ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1650
Query: 379 GAVRDLKEERTALQEQLLQRDLEVKQLL-----QAKADLEKELECAREGEEERREREEVL 433
R EE+ Q +L +++LE ++ L Q + E+EL R E+ ++ ++L
Sbjct: 1651 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1710
Query: 434 REEIQTL-------TSKLQELQ-EMKKEEKE 456
EE+ L T K QEL+ E+ K E
Sbjct: 1711 EEELARLQREAAAATQKRQELEAELAKVRAE 1741
Score = 39.7 bits (91), Expect = 0.009
Identities = 64/353 (18%), Positives = 137/353 (38%), Gaps = 32/353 (9%)
Query: 145 KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRI- 203
K +L + R+L E R+ R+ E+ + S + A +R A + LK ++
Sbjct: 1940 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVERLKAKVE 1997
Query: 204 --LKLEQQCKEKDGTISKLQTD--MKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKK 259
+L ++ +++ +L + K EE A +E LQ L ++ +
Sbjct: 1998 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQTLQQEQSVLDQ 2056
Query: 260 PLGEKKTGAKRQKKMGSALLSLSRS-------VQELTEENQSLKEDLDRVLSTSPTISKT 312
GE + + ++ A + R V+E QS +E K
Sbjct: 2057 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2116
Query: 313 QGYVEWSKPRLLR-RIVELEKKLSV---MESSKSHAAEPVRSHPPACLASSSALHRQPRG 368
+ E R + L +K + ME K A + +R ++ +
Sbjct: 2117 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2176
Query: 369 DRNK-----DHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE--------KE 415
D K + +RL+ + +R+ ++E+L +++++L + KA +E ++
Sbjct: 2177 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2236
Query: 416 LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
+ + +E E+ + + EE L+ QE +++ +ED + A+++
Sbjct: 2237 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2289
Score = 39.3 bits (90), Expect = 0.012
Identities = 60/262 (22%), Positives = 108/262 (41%), Gaps = 33/262 (12%)
Query: 230 EEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQ---------KKMGSALLS 280
EE R+A + EE RL + A+ E ++ L E AK Q ++M ++
Sbjct: 1324 EEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381
Query: 281 LSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGY----VEWSKPRLLRRIVELEKKLSV 336
+ + ++ +S++E+L ++ +S + + E S+ R+ I + +L
Sbjct: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1441
Query: 337 MESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLL 396
E + A ++ A A + Q R ++ ERLR V+D + + + +L
Sbjct: 1442 TERQRGGAEGELQ----ALRARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELA 1496
Query: 397 QR-------DLEVKQLLQAKADLEKELECA----REGEEERREREEVLREEIQTLTSKLQ 445
R E ++ LQA +L + E A R+ E ER + +V E Q S
Sbjct: 1497 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEA 1554
Query: 446 ELQEMKKEEKEDCPEVPHKAQE 467
ELQ + E ++ QE
Sbjct: 1555 ELQSKRASFAEKTAQLERSLQE 1576
Score = 38.1 bits (87), Expect = 0.027
Identities = 82/418 (19%), Positives = 159/418 (38%), Gaps = 75/418 (17%)
Query: 118 VPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR 177
+ GT E ++E ++ +++ +++ + L++L + + + L D R
Sbjct: 1073 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1132
Query: 178 GTDFV-RTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAM 236
G V L ++ + + ++R+ +L ++ + QTD++ LE++ +
Sbjct: 1133 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV-----LAQTDVRQRELEQLGRQL 1187
Query: 237 ETYYEEVHRLQTLLASS----ETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEEN 292
Y E L L + E PL + + + Q + ALL E EE
Sbjct: 1188 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQA-VREQLRQEQALLEEIERHGEKVEEC 1246
Query: 293 Q------------------SLKEDLDRVLST-------SPTISKTQGYVE----WSKPRL 323
Q + K L+ V S S + S Q YV+ +S+
Sbjct: 1247 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1306
Query: 324 L--RRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAV 381
L + I + + L ME + AE R+ LA A + R + A
Sbjct: 1307 LTSQYIKFISETLRRMEEEE-RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1365
Query: 382 RDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEE----------ERRER-- 429
R+ KE + +QE++++R+ Q K +++EL+ R+ E E ER
Sbjct: 1366 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1425
Query: 430 ---EEVLRE-----------------EIQTLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
EE +R E+Q L ++ +E + K++ +E+ + + Q+
Sbjct: 1426 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1483
Score = 36.6 bits (83), Expect = 0.078
Identities = 51/260 (19%), Positives = 97/260 (37%), Gaps = 40/260 (15%)
Query: 201 QRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKP 260
QR + E Q K Q + +L+E +A+ EE R A + ++
Sbjct: 1549 QRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR----AQQQAEAERA 1601
Query: 261 LGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSK 320
E + +R + + L L +E+ ++ + + ++ + ++ +G E
Sbjct: 1602 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1661
Query: 321 PRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGA 380
R +++L+ E K LA +A Q R ++ RLR
Sbjct: 1662 VR--------QRELAEQELEKQRQ-----------LAEGTA---QQRLAAEQELIRLRAE 1699
Query: 381 VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR-----------EGEEERRER 429
+++R L+E+L + E Q + +LE EL R EEE R
Sbjct: 1700 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1759
Query: 430 EEVLREEIQTLTSKLQELQE 449
E ++ ++ + +EL E
Sbjct: 1760 SEKSKQRLEAEAGRFRELAE 1779
Score = 32.3 bits (72), Expect = 1.5
Identities = 31/180 (17%), Positives = 73/180 (40%), Gaps = 11/180 (6%)
Query: 281 LSRSVQELTEEN----QSLKEDLDRVLSTSPTISKTQGYVE---WSKPRLLRRIVELEKK 333
+S +++ + EE Q E+ +R+ + K + E +K + R EL+++
Sbjct: 1315 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1374
Query: 334 LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
+ + AA + + L + + + A R R ++E
Sbjct: 1375 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS----RLRIEE 1430
Query: 394 QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
++ L+++ + + E EL+ R EE ++ +EE + L ++Q+ + K++
Sbjct: 1431 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1490
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,947,642
Number of Sequences: 37866
Number of extensions: 1634162
Number of successful extensions: 18970
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 434
Number of HSP's successfully gapped in prelim test: 1037
Number of HSP's that attempted gapping in prelim test: 10102
Number of HSP's gapped (non-prelim): 5783
length of query: 679
length of database: 18,247,518
effective HSP length: 109
effective length of query: 570
effective length of database: 14,120,124
effective search space: 8048470680
effective search space used: 8048470680
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.