Guide to the Human Genome
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Search of human proteins with 154813193

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|154813193 IQ motif containing E isoform 2 [Homo sapiens]
         (679 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|154813193 IQ motif containing E isoform 2 [Homo sapiens]          1349   0.0  
gi|154813191 IQ motif containing E isoform 1 [Homo sapiens]          1339   0.0  
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    75   3e-13
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    72   1e-12
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    72   2e-12
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    72   2e-12
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           69   2e-11
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           69   2e-11
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           69   2e-11
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     67   4e-11
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...    67   7e-11
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]    67   7e-11
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    65   2e-10
gi|50083293 coiled-coil domain containing 123 [Homo sapiens]           63   8e-10
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             62   2e-09
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    62   2e-09
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    61   3e-09
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi...    61   3e-09
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    61   4e-09
gi|21735548 centrosomal protein 2 [Homo sapiens]                       61   4e-09
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    60   9e-09
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         60   9e-09
gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo sapi...    59   1e-08
gi|221219020 NYD-SP11 protein [Homo sapiens]                           59   1e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        59   1e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        59   1e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         59   1e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         59   1e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         59   1e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         59   1e-08

>gi|154813193 IQ motif containing E isoform 2 [Homo sapiens]
          Length = 679

 Score = 1349 bits (3492), Expect = 0.0
 Identities = 679/679 (100%), Positives = 679/679 (100%)

Query: 1   MFLGTGEPALDTKAKRKAFHKPPPTSPKSPYLSKPRKVASWRSLRTAGSMPLGGRASLTP 60
           MFLGTGEPALDTKAKRKAFHKPPPTSPKSPYLSKPRKVASWRSLRTAGSMPLGGRASLTP
Sbjct: 1   MFLGTGEPALDTKAKRKAFHKPPPTSPKSPYLSKPRKVASWRSLRTAGSMPLGGRASLTP 60

Query: 61  QKLWLGTAKPGSLTQALNSPLTWEHAWTGVPGGTPDCLTDTFRVKRPHLRRSASNGHVPG 120
           QKLWLGTAKPGSLTQALNSPLTWEHAWTGVPGGTPDCLTDTFRVKRPHLRRSASNGHVPG
Sbjct: 61  QKLWLGTAKPGSLTQALNSPLTWEHAWTGVPGGTPDCLTDTFRVKRPHLRRSASNGHVPG 120

Query: 121 TPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTD 180
           TPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTD
Sbjct: 121 TPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTD 180

Query: 181 FVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYY 240
           FVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYY
Sbjct: 181 FVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYY 240

Query: 241 EEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLD 300
           EEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLD
Sbjct: 241 EEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLD 300

Query: 301 RVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSS 360
           RVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSS
Sbjct: 301 RVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSS 360

Query: 361 ALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR 420
           ALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR
Sbjct: 361 ALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR 420

Query: 421 EGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQ 480
           EGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQ
Sbjct: 421 EGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQ 480

Query: 481 DWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKVYKHKKKKAVLDEAAVVLQAAFRGH 540
           DWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKVYKHKKKKAVLDEAAVVLQAAFRGH
Sbjct: 481 DWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKVYKHKKKKAVLDEAAVVLQAAFRGH 540

Query: 541 LTRTKLLASKAHGSEPPSVPGLPDQSSPVPRVPSPIAQATGSPVQEEAIVIIQSALRAHL 600
           LTRTKLLASKAHGSEPPSVPGLPDQSSPVPRVPSPIAQATGSPVQEEAIVIIQSALRAHL
Sbjct: 541 LTRTKLLASKAHGSEPPSVPGLPDQSSPVPRVPSPIAQATGSPVQEEAIVIIQSALRAHL 600

Query: 601 ARARHSATGKRTTTAASTRRRSASATHGDASSPPFLAALPDPSPSGPQALAPLPGDDVNS 660
           ARARHSATGKRTTTAASTRRRSASATHGDASSPPFLAALPDPSPSGPQALAPLPGDDVNS
Sbjct: 601 ARARHSATGKRTTTAASTRRRSASATHGDASSPPFLAALPDPSPSGPQALAPLPGDDVNS 660

Query: 661 DDSDDIVIAPSLPTKNFPV 679
           DDSDDIVIAPSLPTKNFPV
Sbjct: 661 DDSDDIVIAPSLPTKNFPV 679


>gi|154813191 IQ motif containing E isoform 1 [Homo sapiens]
          Length = 695

 Score = 1339 bits (3465), Expect = 0.0
 Identities = 679/695 (97%), Positives = 679/695 (97%), Gaps = 16/695 (2%)

Query: 1   MFLGTGEPALDT----------------KAKRKAFHKPPPTSPKSPYLSKPRKVASWRSL 44
           MFLGTGEPALDT                KAKRKAFHKPPPTSPKSPYLSKPRKVASWRSL
Sbjct: 1   MFLGTGEPALDTGDDSLSAVTFDSDVETKAKRKAFHKPPPTSPKSPYLSKPRKVASWRSL 60

Query: 45  RTAGSMPLGGRASLTPQKLWLGTAKPGSLTQALNSPLTWEHAWTGVPGGTPDCLTDTFRV 104
           RTAGSMPLGGRASLTPQKLWLGTAKPGSLTQALNSPLTWEHAWTGVPGGTPDCLTDTFRV
Sbjct: 61  RTAGSMPLGGRASLTPQKLWLGTAKPGSLTQALNSPLTWEHAWTGVPGGTPDCLTDTFRV 120

Query: 105 KRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSR 164
           KRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSR
Sbjct: 121 KRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSR 180

Query: 165 KDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDM 224
           KDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDM
Sbjct: 181 KDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDM 240

Query: 225 KTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRS 284
           KTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRS
Sbjct: 241 KTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRS 300

Query: 285 VQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHA 344
           VQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHA
Sbjct: 301 VQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHA 360

Query: 345 AEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQ 404
           AEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQ
Sbjct: 361 AEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQ 420

Query: 405 LLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHK 464
           LLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHK
Sbjct: 421 LLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHK 480

Query: 465 AQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKVYKHKKKKA 524
           AQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKVYKHKKKKA
Sbjct: 481 AQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKVYKHKKKKA 540

Query: 525 VLDEAAVVLQAAFRGHLTRTKLLASKAHGSEPPSVPGLPDQSSPVPRVPSPIAQATGSPV 584
           VLDEAAVVLQAAFRGHLTRTKLLASKAHGSEPPSVPGLPDQSSPVPRVPSPIAQATGSPV
Sbjct: 541 VLDEAAVVLQAAFRGHLTRTKLLASKAHGSEPPSVPGLPDQSSPVPRVPSPIAQATGSPV 600

Query: 585 QEEAIVIIQSALRAHLARARHSATGKRTTTAASTRRRSASATHGDASSPPFLAALPDPSP 644
           QEEAIVIIQSALRAHLARARHSATGKRTTTAASTRRRSASATHGDASSPPFLAALPDPSP
Sbjct: 601 QEEAIVIIQSALRAHLARARHSATGKRTTTAASTRRRSASATHGDASSPPFLAALPDPSP 660

Query: 645 SGPQALAPLPGDDVNSDDSDDIVIAPSLPTKNFPV 679
           SGPQALAPLPGDDVNSDDSDDIVIAPSLPTKNFPV
Sbjct: 661 SGPQALAPLPGDDVNSDDSDDIVIAPSLPTKNFPV 695


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 87/430 (20%), Positives = 194/430 (45%), Gaps = 40/430 (9%)

Query: 136  ELKKSLHVQKSDVDLMRTKLRRLEEENSRK--DRQI----EQLLDPSRGTD----FVRTL 185
            +L  S  +++ + +    + ++ EEE +RK  ++Q+     QL D  +  D     + +L
Sbjct: 1331 KLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESL 1390

Query: 186  AEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMK--TTNLEEMRIAMETYYEEV 243
             E +         L QR+ +      + + T ++LQ ++   T +L+  R       ++ 
Sbjct: 1391 EEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQ 1450

Query: 244  HRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTE-------ENQSLK 296
             +   LLA  ++   +   E+       ++  +  LSL+R+++E  E       +N+ L+
Sbjct: 1451 KKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLR 1510

Query: 297  EDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACL 356
             D++ ++S+   + K    +E SK  L +++ E+  +L  +E  +  A E  +      +
Sbjct: 1511 ADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELE-DELQATEDAKLRLEVNM 1569

Query: 357  ASSSALHR---QPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEV---KQLLQAKA 410
             +  A      Q R ++N++ +RL   ++ ++E    L+++  QR L V   K++     
Sbjct: 1570 QAMKAQFERDLQTRDEQNEEKKRL--LIKQVRELEAELEDERKQRALAVASKKKMEIDLK 1627

Query: 411  DLEKELECAREGEEERREREEVLREEIQTLTSKLQEL-----------QEMKKEEKEDCP 459
            DLE ++E A +  +E  ++   L+ +++    +L+E            +E +K+ K    
Sbjct: 1628 DLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEA 1687

Query: 460  EVPHKAQELPAPTPSSRHCEQDWPPDSSE-EGLPRPRSPCSDGRRDAAARVLQAQWKVYK 518
            E+    +EL +   + RH EQ+    + E       +S   D +R   AR+ Q + ++ +
Sbjct: 1688 EILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEE 1747

Query: 519  HKKKKAVLDE 528
             +    +L++
Sbjct: 1748 EQSNMELLND 1757



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 73/374 (19%), Positives = 161/374 (43%), Gaps = 44/374 (11%)

Query: 127  KEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEE-NSRKDRQIE-----QLLDPSRGTD 180
            K+D+   + EL+KS    +  V+ MRT+L  LE+E  + +D ++      Q +      D
Sbjct: 1520 KDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERD 1579

Query: 181  FVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTIS---KLQTDMK--TTNLEEMRIA 235
                  +       +I  +++   +LE + K++   ++   K++ D+K     +E    A
Sbjct: 1580 LQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA 1639

Query: 236  METYYEEVHRLQTL-------LASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQEL 288
             +   +++ +LQ         L  +  +  +   + K   K+ K + + +L L   +   
Sbjct: 1640 RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASS 1699

Query: 289  TEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPV 348
                +  +++ D +       +  +  +   K RL  RI +LE++L   +S+     +  
Sbjct: 1700 ERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRF 1759

Query: 349  RS------------HPPACLASSSALHRQPRGDRNKD----HERLRGAVRD-LKEERTAL 391
            R                   A  S   RQ    +NK+     + L GAV+   K   +AL
Sbjct: 1760 RKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISAL 1819

Query: 392  QEQLLQRDLEVKQLLQAKA-------DLEKEL-ECAREGEEERREREEVLREEIQTLTSK 443
            + ++ Q + +++Q  + +A         EK+L E   + E+ERR  ++  +E+++   ++
Sbjct: 1820 EAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQ-YKEQMEKANAR 1878

Query: 444  LQELQEMKKEEKED 457
            +++L+   +E +E+
Sbjct: 1879 MKQLKRQLEEAEEE 1892



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 92/470 (19%), Positives = 190/470 (40%), Gaps = 80/470 (17%)

Query: 119  PGTPVYREKEDMY---DEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDP 175
            P   V R++E++    +E++++K+     + +++ M  K ++L EE +    Q++   + 
Sbjct: 843  PLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETEL 902

Query: 176  SRGTDFVRT-LAEKRPDASWVINGLKQRILK---------------------LEQQCKEK 213
                + +R  LA K+ +   +++ L+ R+ +                     LE+Q  E+
Sbjct: 903  FAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE 962

Query: 214  DGTISKLQ-----TDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGA 268
            +G   KLQ      + K   +EE  + +E    +  + + L+          L E++  A
Sbjct: 963  EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA 1022

Query: 269  KRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIV 328
            K   K+        R+ QE+   +  L+E L +   T   + K +  ++     L  +I 
Sbjct: 1023 KNLAKI--------RNKQEVMISD--LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA 1072

Query: 329  ELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHER-LRGAVRDLKEE 387
            EL+ ++  ++   +   E ++      LA         RGD    H+      VR+L+ +
Sbjct: 1073 ELQAQIDELKLQLAKKEEELQG----ALA---------RGDDETLHKNNALKVVRELQAQ 1119

Query: 388  RTALQEQLLQRDLEVKQLLQAKADLEKELECAR------------------EGEEERRER 429
               LQE          +  + K DL +ELE  +                  + E+E  E 
Sbjct: 1120 IAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAEL 1179

Query: 430  EEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSE- 488
            ++ L EE +   +++Q++++      E+  E   +A+   A    ++   Q    D+ E 
Sbjct: 1180 KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK---QGLETDNKEL 1236

Query: 489  ----EGLPRPRSPCSDGRRDAAARVLQAQWKVYKHKKKKAVLDEAAVVLQ 534
                + L + ++     R+   A+V +   KV +  + +  L E A  LQ
Sbjct: 1237 ACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 75/366 (20%), Positives = 147/366 (40%), Gaps = 42/366 (11%)

Query: 126  EKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEE-NSRKDRQIEQLLDPSRGTDFVRT 184
            E  D+ D+I EL+       + +D ++ +L + EEE      R  ++ L  +     VR 
Sbjct: 1063 ETTDLQDQIAELQ-------AQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRE 1115

Query: 185  LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMK-----TTNLEEMRIAMETY 239
            L  +  +        K    K E+Q ++    +  L+T+++     T   +E+R   E  
Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE-- 1173

Query: 240  YEEVHRLQTLLASSETTGKKPLGE-KKTGAKRQKKMGSALLSLSRSVQELTEENQSLKED 298
             +EV  L+  L       +  + + ++  A   +++   L    R    L +  Q L+ D
Sbjct: 1174 -QEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETD 1232

Query: 299  LDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLAS 358
               +      + + +   E  + +L  ++ EL  K+S  +  +   AE            
Sbjct: 1233 NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNV 1292

Query: 359  SSALHR-QPRGDR-NKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKA-DLEKE 415
            S+ L   + +G +  KD   L   ++D +E        LLQ +   K  L ++   LE+E
Sbjct: 1293 STLLEEAEKKGIKFAKDAASLESQLQDTQE--------LLQEETRQKLNLSSRIRQLEEE 1344

Query: 416  LECAREGEEERREREEVLREEIQTLTSKL--------------QELQEMKKEEKEDCPEV 461
                +E +EE  E  + L +++  L S+L              + L+E KK+  +D   +
Sbjct: 1345 KNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEAL 1404

Query: 462  PHKAQE 467
              + +E
Sbjct: 1405 SQRLEE 1410



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 51/242 (21%), Positives = 88/242 (36%), Gaps = 35/242 (14%)

Query: 125  REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF--- 181
            +E++++ DEI            +   +  ++ +LEEE   +   +E L D  R T     
Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVD 1767

Query: 182  --------VRTLAEKRPDASWVI----NGLKQRILKLEQQCKEK-DGTISKLQT------ 222
                     R+ A+K  +A   +      LK ++ +LE   K K   TIS L+       
Sbjct: 1768 TLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLE 1827

Query: 223  DMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLS 282
            +      +E   A +       +L+ +    E   +     K+   K   +M      L 
Sbjct: 1828 EQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLE 1887

Query: 283  RSVQELTEENQSLK-------------EDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVE 329
             + +E T  N S +             E L R +ST     +  G + +S  R  RR + 
Sbjct: 1888 EAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLH 1947

Query: 330  LE 331
            LE
Sbjct: 1948 LE 1949


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 75/354 (21%), Positives = 157/354 (44%), Gaps = 33/354 (9%)

Query: 132  DEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPD 191
            +E+ +L++ ++ Q  +++ ++T     E       +++E       G + +R L  K  +
Sbjct: 1337 EEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDE 1396

Query: 192  ASWVINGLKQRILKLEQQCKEKDGTISKLQT------DMKTTNLEEMRIAMETYYEEVHR 245
               +I+  ++ +  L  Q  EK+  ++K+QT      D+      ++ +  + + E + +
Sbjct: 1397 LQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQ 1456

Query: 246  LQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLST 305
            LQ  L   +   ++   E +   + Q+K+ +AL+S     +E  +EN+SL+E+L     T
Sbjct: 1457 LQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISR----KEALKENKSLQEELSLARGT 1512

Query: 306  SPTISKTQGYVE-------WSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLAS 358
               ++K+   VE         K  +L R+  L+++   + +    +    +S   +C + 
Sbjct: 1513 IERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESL 1572

Query: 359  SSALHRQPRGDRNKDHERLRGAVRDLKE----ERTALQEQLLQRDLEVKQLLQAKADLEK 414
              AL         +D E+L   +  LK     E T  QE+  +   E + LLQ+  ++  
Sbjct: 1573 KLALE-----GLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSN 1627

Query: 415  ELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
            E        E  +   E +R+E Q L  KL+  +  KKE ++   E   + +E+
Sbjct: 1628 E-------AERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEM 1674



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 78/391 (19%), Positives = 167/391 (42%), Gaps = 76/391 (19%)

Query: 125  REKED----MYDEIIELKKSLHVQKSDVDLMRTKL-RRLEEENSRKDRQIEQ-LLDPSRG 178
            R KED    + D++ ++  S+H+++  +++ R +  +++ E  ++ + Q++Q + D  +G
Sbjct: 2227 RLKEDNCSVLKDQLRQM--SIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQG 2284

Query: 179  TDFVRTLAEKRPDASWVINGLKQRILKLE-----------------QQCKEKDGTI---- 217
             +  + L  +  +   + +  +  + KLE                 ++CKE+ G +    
Sbjct: 2285 EN--KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGII 2342

Query: 218  ---------SKLQTDMKTTNLEEMRIAMETYYEEVH----RLQTLLASSETTGKKPLGEK 264
                     SK   +   T+L+  R      +EE++    ++ +LL+  E   +  + E 
Sbjct: 2343 RQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAEL 2402

Query: 265  KTGAKRQKKMGSALLSLSRSVQ-ELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRL 323
            +    ++ K    LLS        L EEN+   +  ++++ T  TI K            
Sbjct: 2403 RQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKEN---------- 2452

Query: 324  LRRIVELE---KKLSVMESSKSHAA---EPVRSHPPACLASSSALHRQPRGDRNKDHERL 377
            +++  +L+   K +S +++ +       + +     + +     L ++   + NK  E +
Sbjct: 2453 IQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEI 2512

Query: 378  RGA---VRDLKEERTALQEQLLQ-----------RDLEVKQLLQAKADLEKELECAREGE 423
            RG    + DL  E   L  +L+Q           +D + KQLL+ +    KELE      
Sbjct: 2513 RGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKL 2572

Query: 424  EERREREEVLREEIQTLTSKLQ-ELQEMKKE 453
            EE+ +  E   E+++   + LQ E Q++ KE
Sbjct: 2573 EEKLKESEEANEDLRRSFNALQEEKQDLSKE 2603



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 89/390 (22%), Positives = 162/390 (41%), Gaps = 69/390 (17%)

Query: 110  RRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQI 169
            +++A N     T +  E++ +  ++ EL        S V  +R ++++LE   +  +RQ 
Sbjct: 729  KKNADNNSSAFTALSEERDQLLSQVKEL--------SMVTELRAQVKQLEMNLAEAERQ- 779

Query: 170  EQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNL 229
                   R  D+    A          N L ++I  L  + K KD  I  LQ +     L
Sbjct: 780  -------RRLDYESQTAHD--------NLLTEQIHSLSIEAKSKDVKIEVLQNE-----L 819

Query: 230  EEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQ--- 286
            +++++        +  LQ+ L + E+       E   GA+R + + S +  LS+++    
Sbjct: 820  DDVQLQFSEQSTLIRSLQSQLQNKES-------EVLEGAERVRHISSKVEELSQALSQKE 872

Query: 287  -ELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVEL-EKKLSVMESSK--- 341
             E+T+ +Q L E    V +   TI +    V      +  ++V+L E+K S+    K   
Sbjct: 873  LEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLK 932

Query: 342  ------SHAAEPVRSHPPACLASSSALHR-----QPRGDRNKDHERLRGAVRDLKEERTA 390
                  S A E  +         SS L +      P G  +K  E L+     LK+E   
Sbjct: 933  EQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISK--EELQHEFDLLKKENEQ 990

Query: 391  LQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQ-----------T 439
             + +L    +  K+LLQ  + LE+EL   ++  ++     E  R E++            
Sbjct: 991  RKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKC 1050

Query: 440  LTSKLQELQ-EMKKEEKEDCPEVPHKAQEL 468
            +TSK QE++  +K+   E   E+ H  ++L
Sbjct: 1051 VTSKCQEIEIYLKQTISEKEVELQHIRKDL 1080



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 84/411 (20%), Positives = 162/411 (39%), Gaps = 78/411 (18%)

Query: 128  EDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSR----KDRQIEQLLDPSRGTDFVR 183
            E +   + +++  +  Q  + D +  +L  L+EE  +     DR + +    S   + ++
Sbjct: 1514 ERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLK 1573

Query: 184  T----LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISK-----LQTDMKTTN-LEEMR 233
                 L E +      I  LK   +    + +EK   + K     LQ+    +N  E ++
Sbjct: 1574 LALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQ 1633

Query: 234  IAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQ----ELT 289
              +E   +E   L   L S+E   K+   + +   +  ++M   +   ++S Q    EL 
Sbjct: 1634 HVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELE 1693

Query: 290  EENQ-------------------------SLKEDLDRVLSTSPTISKTQGYVEWSKPRLL 324
            EEN                          S+KE+L+RV     T+SK    +   K  L 
Sbjct: 1694 EENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLS 1753

Query: 325  RRIVELE-------KKLSVMESSKSH------AAEPVRSHP--------------PACLA 357
              + +L+        K + +E+++ H        E  +S P              P C  
Sbjct: 1754 EEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSE 1813

Query: 358  S-SSALHRQPRGDRN-KDHERLRGAVRDLKE--ERTALQEQLLQRDLEVKQLLQAKADLE 413
            S  SA    P   ++   H+ +   ++ + +  ER A  E+  Q++ E  Q L+ + +  
Sbjct: 1814 SVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTL 1873

Query: 414  KELECAREGE----EERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPE 460
                  ++GE    +E   +  +L ++IQ   S++ +L+E  +EEK+D  E
Sbjct: 1874 LSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEE 1924



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 82/391 (20%), Positives = 156/391 (39%), Gaps = 53/391 (13%)

Query: 98   LTDTFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRR 157
            L +  R  R H+    S        + + +ED+ +++I +K S   Q  +V L + K   
Sbjct: 2508 LKEEIRGLRSHMDDLNSENAKLDAELIQYREDL-NQVITIKDSQQKQLLEVQLQQNK--E 2564

Query: 158  LEEENSRKDRQIEQLLDPSRGTDFVRT---LAEKRPDASWVINGLKQRILKLEQQCK--E 212
            LE + ++ + ++++  + +   D  R+   L E++ D S  I  LK  I +L +Q    +
Sbjct: 2565 LENKYAKLEEKLKESEEANE--DLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQ 2622

Query: 213  KDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGE----KKTGA 268
            ++GT+      +K               EEVHRL  L +SS+    +   E    +K  A
Sbjct: 2623 EEGTLGLYHAQLKVKE------------EEVHRLSALFSSSQKRIAELEEELVCVQKEAA 2670

Query: 269  KR----QKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLL 324
            K+    + K+   L  L      +  E ++ +E +  +      + +    V      L 
Sbjct: 2671 KKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLT 2730

Query: 325  RRIVELEKKLSVMESSKSHAAEPV---RSHPPACLASSSALHRQPRGDRNKDH------- 374
             +I    + +S +++S+ HA E +   +    A L   + L  Q   +R +D        
Sbjct: 2731 AQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAF 2790

Query: 375  -------------ERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
                         E+L   +    E+   L  QL     +V+   +A A L+ E +    
Sbjct: 2791 SMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWN 2850

Query: 422  GEEERREREEVLREEIQTLTSKLQELQEMKK 452
              E+ R+ EE  +      ++   E+Q +KK
Sbjct: 2851 ELEKFRKSEEGKQRSAAQPSTSPAEVQSLKK 2881



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 73/348 (20%), Positives = 148/348 (42%), Gaps = 51/348 (14%)

Query: 151  MRTKLRRLEEENSRKDRQI----EQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKL 206
            M  K+ +L EE      +I    EQL   SR  +  +   E+  + S   +GLKQ   ++
Sbjct: 910  MTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVS---SGLKQNYDEM 966

Query: 207  E---QQCKEK---DGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKK- 259
                Q  KE+   +  + K + + +   L+   I  +   + V RL+  LA+ +   KK 
Sbjct: 967  SPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKE 1026

Query: 260  -PLGEKKTGAKRQKKMGSAL-------------LSLSRSVQELTEENQSLKEDLDRVLST 305
             PL E + G   + K                  + L +++ E   E Q +++DL+  L+ 
Sbjct: 1027 IPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAA 1086

Query: 306  SPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQ 365
                 + Q  V+     L  +  +++   + +  +++   + + S+  A    S AL ++
Sbjct: 1087 E---EQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE 1143

Query: 366  -----PRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR 420
                 P    + +H +      +L+E+  AL+++        K+ LQ K  L++ L   +
Sbjct: 1144 TVVISPPCTGSSEHWK-----PELEEKILALEKE--------KEQLQKK--LQEALTSRK 1188

Query: 421  EGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
               ++ +E+E  LREE++        LQE   E+ ++   +  + ++L
Sbjct: 1189 AILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQL 1236



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 69/342 (20%), Positives = 147/342 (42%), Gaps = 38/342 (11%)

Query: 136  ELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEK-----RP 190
            EL++ L  ++ +V  ++    R +E+ S  +R ++ L       +FV+T ++K     + 
Sbjct: 2009 ELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKAL-------EFVQTESQKDLEITKE 2061

Query: 191  DASWVINGLKQRILKLEQQCKEKDGTIS----------KLQTDMKTTNLEEMRIAMETYY 240
            + +  +   K+   +L       D T S          KL+ ++++ N E ++  M+   
Sbjct: 2062 NLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQS-NKESVKSQMKQKD 2120

Query: 241  EEVHRLQTLLASSETTGKKPLGEKKTGAKRQK-KMGSALLSLSRSVQELTEENQSLKEDL 299
            E++ R            KK + EK    +R+K  +   +  +  ++ +  +E Q L+E+L
Sbjct: 2121 EDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENL 2180

Query: 300  DRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASS 359
            D  ++     +K+   ++  + R++    + E+K S    SK    E +R     C    
Sbjct: 2181 DSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKE---EEIRLKEDNC---- 2233

Query: 360  SALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQ-----LLQAKADLEK 414
            S L  Q R   +   E L+  +  L+ ++  + E   Q +++++Q     L     +L  
Sbjct: 2234 SVLKDQLR-QMSIHMEELKINISRLEHDK-QIWESKAQTEVQLQQKVCDTLQGENKELLS 2291

Query: 415  ELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKE 456
            +LE  R      +     L  E+++L  +L +L    ++ KE
Sbjct: 2292 QLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKE 2333



 Score = 37.0 bits (84), Expect = 0.060
 Identities = 54/284 (19%), Positives = 119/284 (41%), Gaps = 37/284 (13%)

Query: 167  RQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKT 226
            +QI+QL +   G +  +   +K  + S  +   K  +L    Q   KDG +  LQ ++  
Sbjct: 1840 QQIDQLKERIAGLEEEK---QKNKEFSQTLENEKNTLLS---QISTKDGELKMLQEEVTK 1893

Query: 227  TNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQ 286
             NL   +I      EE+ R+  L  ++E        E+K     ++++ + L  L+ S+ 
Sbjct: 1894 MNLLNQQIQ-----EELSRVTKLKETAE--------EEKDDL--EERLMNQLAELNGSIG 1938

Query: 287  ELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKL--SVMESSKSHA 344
               ++    +   + + S    + K    +E  K +L++   ++E ++    +E  +   
Sbjct: 1939 NYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQ 1998

Query: 345  AEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQ 404
             EP            +  H +   +  K+ ++    V+ L+++    QE++   +  VK 
Sbjct: 1999 KEP-----------GNKSHAKELQELLKEKQQ---EVKQLQKDCIRYQEKISALERTVKA 2044

Query: 405  LLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQ 448
            L   + + +K+LE  +E   +  E  +  + E+ +    L + Q
Sbjct: 2045 LEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQ 2088



 Score = 34.7 bits (78), Expect = 0.30
 Identities = 72/374 (19%), Positives = 138/374 (36%), Gaps = 77/374 (20%)

Query: 103 RVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEEN 162
           + K   L +        G  V   +    +++ +  KS   ++ +++ ++ KL+  EE  
Sbjct: 101 KAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELI 160

Query: 163 SRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQT 222
           S    Q+ Q              AE+   +S  +    +  + ++QQ +EK+  IS LQ 
Sbjct: 161 STLQAQLTQ------------AQAEQPAQSSTEM----EEFVMMKQQLQEKEEFISTLQA 204

Query: 223 DMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLS 282
            +  T  E+   A +   E+  R +T +   E      L +  T A  + +M   L  L 
Sbjct: 205 QLSQTQAEQ--AAQQVVREKDARFETQVRLHE----DELLQLVTQADVETEMQQKLRVLQ 258

Query: 283 RSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKS 342
           R ++E  E      + +D +L    T ++ +  +             L ++L  ME+   
Sbjct: 259 RKLEEHEESLVGRAQVVD-LLQQELTAAEQRNQI-------------LSQQLQQMEA--- 301

Query: 343 HAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE----QLLQR 398
                                         +H  LR  V   +EE   L E    ++ +R
Sbjct: 302 ------------------------------EHNTLRNTVETEREESKILLEKMELEVAER 331

Query: 399 DLEVKQLLQAKADLEKELECAREGEEERREREEVLRE----EIQTLTSKLQELQEMKKEE 454
            L    L +    L ++ E A + + E   R   L +    E++  TS +  LQ+  +E 
Sbjct: 332 KLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQEL 391

Query: 455 KEDCPEVPHKAQEL 468
           +  C  +  +  +L
Sbjct: 392 QSACDALKDQNSKL 405



 Score = 34.7 bits (78), Expect = 0.30
 Identities = 72/381 (18%), Positives = 145/381 (38%), Gaps = 79/381 (20%)

Query: 127  KEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLA 186
            KE++  E   LKK    +K  +       + L +  SR + ++  L D S+         
Sbjct: 974  KEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESK--------- 1024

Query: 187  EKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRL 246
            ++ P            + + E+   E+D    +      T+  +E+ I +          
Sbjct: 1025 KEIP------------LSETERGEVEEDKENKEYSEKCVTSKCQEIEIYL---------- 1062

Query: 247  QTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEE-NQSLKEDLDRVLST 305
                       K+ + EK+   +  +K     L+     Q L ++ NQ+L++  +++   
Sbjct: 1063 -----------KQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLL 1111

Query: 306  SPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQ 365
               IS+ Q  ++    +L+    +     SV     +   E V   PP C  SS   H +
Sbjct: 1112 QAEISENQAIIQ----KLITSNTDASDGDSV-----ALVKETVVISPP-CTGSSE--HWK 1159

Query: 366  PRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEE 425
            P  +     E++    ++ ++ +  LQE L  R   +K+  + +  L +EL+  ++    
Sbjct: 1160 PELE-----EKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNR 1214

Query: 426  RREREEVLREEIQTLTSKLQELQEMKKE----------EKEDCPEVPHKAQEL------- 468
             +E+ +   +E + +  +L++LQ   +E          ++E C   P   + L       
Sbjct: 1215 LQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQH 1274

Query: 469  -PAPTPSSRHCEQDWPPDSSE 488
               P   S  C  DWP  S +
Sbjct: 1275 HTQPVLESNLC-PDWPSHSED 1294


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 77/352 (21%), Positives = 148/352 (42%), Gaps = 34/352 (9%)

Query: 153  TKLRRLEEENSRKDRQIEQLLDPSRGTD-FVRTL-------AEKRPDASWVINGLKQ--- 201
            TKLR+LEEE +    Q+++ ++  +  +  + TL        +K  D +  +  L++   
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402

Query: 202  ----RILKLEQQCKEKDGTISKLQT---------DMKTTNLEEMRIAMETYYEEVHRLQT 248
                 I  L QQ +EK     KL+          D    +L+  R  +    ++  +   
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462

Query: 249  LLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEE-------NQSLKEDLDR 301
            LLA  +    K   E+       ++  +  LSL+R+++E  E        N+ LK +++ 
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522

Query: 302  VLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
            ++S+   + K    +E SK  L  ++ E++ +L  +E       +          A    
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582

Query: 362  LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEV---KQLLQAKADLEKELEC 418
              R  +    ++ E+ R   R L E  T L+++  QR L     K+L     DLE + + 
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642

Query: 419  AREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPA 470
            A +G EE  ++   L+ +++    +L++ +  + E      E   KA+ L A
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1694



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 78/359 (21%), Positives = 145/359 (40%), Gaps = 38/359 (10%)

Query: 121  TPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRG-- 178
            T  Y EK   YD++ + K  L  +  D+ +     R+L     +K R+ +QLL   +   
Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471

Query: 179  ------TDFVRTLA-EKRPDASWVINGLKQRILKLEQ--------QCKEKDGTISKLQTD 223
                   D     A EK   A  +   L++ +   E+        + + +D   SK    
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531

Query: 224  MKTTNLEEMRIAMETYYEEVH-RLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLS 282
                 LE+ + A+ET  EE+  +L+ L    + T    L       + +  M +      
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL-------RLEVNMQALKGQFE 1584

Query: 283  RSVQELTEENQSLKEDLDRVLSTSPT----ISKTQGYVEWSKPRLLRRIVELEKKLSVME 338
            R +Q   E+N+  +  L R L    T      K +     +K +L   + +LE +     
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644

Query: 339  SSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQL--L 396
              +  A + +R      L +     ++   D     + +    ++ +++  +L+  L  L
Sbjct: 1645 KGREEAIKQLRK-----LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1699

Query: 397  QRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEK 455
            Q DL   +  + +ADLEKE E A E       R   L++E + L +++ +L+E  +EE+
Sbjct: 1700 QEDLAAAERARKQADLEKE-ELAEELASSLSGR-NALQDEKRRLEARIAQLEEELEEEQ 1756



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 74/337 (21%), Positives = 135/337 (40%), Gaps = 23/337 (6%)

Query: 138  KKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVIN 197
            KK L     D++L      +  EE  ++ R+++  +      DF R L + R     +  
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK-----DFQRELEDARASRDEIFA 1680

Query: 198  GLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTG 257
              K+     E++ K  +  + +LQ D+        +  +E        L   LASS +  
Sbjct: 1681 TAKEN----EKKAKSLEADLMQLQEDLAAAERARKQADLEK-----EELAEELASSLSGR 1731

Query: 258  KKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVE 317
                 EK+    R  ++   L     +++ +++  +   +  +++ +   T   T    E
Sbjct: 1732 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1791

Query: 318  WSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERL 377
             ++ +L R+  EL  KL  ME +       V+S   + +A+  A   Q      ++    
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGA-------VKSKFKSTIAALEAKIAQLEEQVEQEAREK 1844

Query: 378  RGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEI 437
            + A + LK++   L+E LLQ + E K   Q K   EK     ++ + +  E EE   + I
Sbjct: 1845 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE-SQRI 1903

Query: 438  QTLTSKLQ-ELQEMKKEEKEDCPEVPHKAQELPAPTP 473
                 KLQ EL E  +  +    EV     +L  P P
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1940



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 70/355 (19%), Positives = 153/355 (43%), Gaps = 54/355 (15%)

Query: 129  DMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEK 188
            D+  +I ELK  L  ++ +   ++  L RL++E ++K+  +++          +R L   
Sbjct: 1080 DLQAQIAELKMQLAKKEEE---LQAALARLDDEIAQKNNALKK----------IRELEGH 1126

Query: 189  RPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMK-----TTNLEEMRIAMETYYEEV 243
              D    ++  +    K E+Q ++    +  L+T+++     T   +E+R   E   +EV
Sbjct: 1127 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE---QEV 1183

Query: 244  HRLQTLLASSETTGKKPLGE-KKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRV 302
              L+  L     + +  + E ++  A+  +++   L    R+   L +  Q+L+++   +
Sbjct: 1184 TVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1243

Query: 303  LSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVR------------- 349
                  + + +  VE  K +L  ++ EL+ K S  E +++   + V              
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1303

Query: 350  ----------SHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRD 399
                      +   A L+S     ++   +  +    +   +R L+EER +LQ+Q L  +
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-LDEE 1362

Query: 400  LEVKQLLQAK--------ADLEKELECAREGEEERREREEVLREEIQTLTSKLQE 446
            +E KQ L+          +D +K+L+      E   E ++  ++EI+ LT + +E
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1417



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 85/413 (20%), Positives = 171/413 (41%), Gaps = 73/413 (17%)

Query: 120  GTPVYREKEDMYDEIIELKKSLHVQKSDVDLMR-------TKLRRLEEENSRKDRQIEQL 172
            G  +  E++ M  ++++L++ L  +++    ++        K+++LE+E    D Q  +L
Sbjct: 945  GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 1004

Query: 173  -----LDPSRGTDFVRTLAEKRPDAS----------WVINGLKQRILKLEQQCKEKDGTI 217
                 L   R +D    LAE+   A            +I+ L+ R+ K E+  +E +   
Sbjct: 1005 SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK 1064

Query: 218  SKLQTDMKT---------TNLEEMRIAMETYYEEVH----RLQTLLASSETTGKKPLGEK 264
             KL+ D              + E+++ +    EE+     RL   +A      KK    +
Sbjct: 1065 RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1124

Query: 265  KTGAKRQKKMGS---ALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKP 321
               +  Q+ + S   A     +  ++L EE ++LK +L+  L ++ T  + +   E    
Sbjct: 1125 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE---- 1180

Query: 322  RLLRRIVELEKKLSVMESSKSHAA---EPVRSHPPACLASSSALHRQPRGDRNKDHER-- 376
               + +  L+K L   E ++SH A   E  + H  A    +  L +  R   N D  +  
Sbjct: 1181 ---QEVTVLKKALD--EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1235

Query: 377  -------LRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKAD--------------LEKE 415
                   L G +R L + +  ++ +  + + +V++L    +D              L+ E
Sbjct: 1236 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1295

Query: 416  LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
            +E       E   +   L +++ +L+S+LQ+ QE+ +EE      V  K ++L
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1348



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 61/274 (22%), Positives = 112/274 (40%), Gaps = 30/274 (10%)

Query: 197  NGLKQRILKLEQQCKEKDGTISKLQTDMKT-TNLEEMRIAMETYYEEV----HRLQTLLA 251
            N LK+   K  Q  +EK+    +LQ + +     EEMR+ +    +E+    H ++  L 
Sbjct: 880  NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 939

Query: 252  SSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISK 311
              E  G++   E+K       KM   +L L   ++E  EE    K  L++V + +  I K
Sbjct: 940  EEEDRGQQLQAERK-------KMAQQMLDLEEQLEE--EEAARQKLQLEKVTAEAK-IKK 989

Query: 312  TQGYV--------EWSKPRLL--RRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
             +  +        + SK R L   RI +L   L+  E    +  +    H          
Sbjct: 990  LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1049

Query: 362  LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
            L ++      K  + L    R L+ + +   EQ+     ++ +L    A  E+EL+ A  
Sbjct: 1050 LKKE-----EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1104

Query: 422  GEEERREREEVLREEIQTLTSKLQELQEMKKEEK 455
              ++   ++    ++I+ L   + +LQE    E+
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 85/388 (21%), Positives = 159/388 (40%), Gaps = 32/388 (8%)

Query: 121  TPVYREKEDMYDEI-IELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGT 179
            T +  + E M  E+ + LKK    +KS  +L + K R+LE + S    QI  L   ++  
Sbjct: 1033 TKLKNKHESMISELEVRLKKE---EKSRQELEKLK-RKLEGDASDFHEQIADL--QAQIA 1086

Query: 180  DFVRTLAEKRPDASWVINGLKQRILKLEQQCK---EKDGTISKLQTDMKTTNLEEMRIAM 236
            +    LA+K  +    +  L   I +     K   E +G IS LQ D+ +      +   
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146

Query: 237  ET--YYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKK---MGSALLSLSRS----VQE 287
            +     EE+  L+T L   E T      +++  AKR+++   +  AL   +RS    VQE
Sbjct: 1147 QKRDLGEELEALKTEL---EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203

Query: 288  LTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEP 347
            + +++    E+L   L       + +  ++ +K  L +   +L  +L V+  +K      
Sbjct: 1204 MRQKHAQAVEELTEQLEQ---FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1257

Query: 348  VRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQ 407
               H    L +     +    D  +    L   V  L+ E  ++   L + + +  +L +
Sbjct: 1258 --EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315

Query: 408  AKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
              A L  +L+  +E  +E   ++  +  +++ L  +   LQ+   EE E    +      
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375

Query: 468  LPAPTPSSRHCEQDWPP--DSSEEGLPR 493
            L      S+   QD+    ++ EEG  R
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKR 1403



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 49/187 (26%), Positives = 79/187 (42%), Gaps = 32/187 (17%)

Query: 269  KRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWS--KPRLLRR 326
            +RQ+K  + L  L +   +LTEE   L+E L          ++T+ Y E    + RL  +
Sbjct: 873  ERQQKAENELKELEQKHSQLTEEKNLLQEQLQ---------AETELYAEAEEMRVRLAAK 923

Query: 327  IVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKE 386
              ELE+ L  ME               A L       +Q + +R K  +++      L+E
Sbjct: 924  KQELEEILHEME---------------ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968

Query: 387  ERTALQEQLLQRDLEVKQLLQAK-ADLEKELECAREGEEERREREEVLREEIQTLTSKLQ 445
            E  A Q+  L+     K   +AK   LE E+    +   +  +  ++L E I  LT+ L 
Sbjct: 969  EEAARQKLQLE-----KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023

Query: 446  ELQEMKK 452
            E +E  K
Sbjct: 1024 EEEEKAK 1030



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 38/178 (21%), Positives = 73/178 (41%), Gaps = 20/178 (11%)

Query: 370  RNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERRER 429
            RN    RL   V+ L +  T  +E++  ++ E+++  + +   E EL+   +   +  E 
Sbjct: 837  RNWQWWRLFTKVKPLLQV-TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE 895

Query: 430  EEVLREEIQT--------------LTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSS 475
            + +L+E++Q               L +K QEL+E+  E +    E   + Q+L A     
Sbjct: 896  KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 955

Query: 476  RHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKVY-----KHKKKKAVLDE 528
                 D      EE   R +        +A  + L+ +  V      K  K++ +L+E
Sbjct: 956  AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 40/222 (18%), Positives = 91/222 (40%), Gaps = 16/222 (7%)

Query: 126  EKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR-GTDFVRT 184
            EKE++ +E+       +  + +   +  ++ +LEEE   +   +E + D  R  T     
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775

Query: 185  LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEE-V 243
            L+ +           +    +LE+Q KE              + L EM  A+++ ++  +
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKE------------LRSKLHEMEGAVKSKFKSTI 1823

Query: 244  HRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVL 303
              L+  +A  E   ++   EK+   K  K+    L  +   V++  +  +  KE  ++  
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1883

Query: 304  STSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAA 345
            +    + +     E    R+     +L+++L   E+++S+ A
Sbjct: 1884 ARVKQLKRQLEEAEEESQRINANRRKLQRELD--EATESNEA 1923


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 77/352 (21%), Positives = 148/352 (42%), Gaps = 34/352 (9%)

Query: 153  TKLRRLEEENSRKDRQIEQLLDPSRGTD-FVRTL-------AEKRPDASWVINGLKQ--- 201
            TKLR+LEEE +    Q+++ ++  +  +  + TL        +K  D +  +  L++   
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395

Query: 202  ----RILKLEQQCKEKDGTISKLQT---------DMKTTNLEEMRIAMETYYEEVHRLQT 248
                 I  L QQ +EK     KL+          D    +L+  R  +    ++  +   
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455

Query: 249  LLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEE-------NQSLKEDLDR 301
            LLA  +    K   E+       ++  +  LSL+R+++E  E        N+ LK +++ 
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515

Query: 302  VLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
            ++S+   + K    +E SK  L  ++ E++ +L  +E       +          A    
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575

Query: 362  LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEV---KQLLQAKADLEKELEC 418
              R  +    ++ E+ R   R L E  T L+++  QR L     K+L     DLE + + 
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635

Query: 419  AREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPA 470
            A +G EE  ++   L+ +++    +L++ +  + E      E   KA+ L A
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1687



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 78/359 (21%), Positives = 145/359 (40%), Gaps = 38/359 (10%)

Query: 121  TPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRG-- 178
            T  Y EK   YD++ + K  L  +  D+ +     R+L     +K R+ +QLL   +   
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464

Query: 179  ------TDFVRTLA-EKRPDASWVINGLKQRILKLEQ--------QCKEKDGTISKLQTD 223
                   D     A EK   A  +   L++ +   E+        + + +D   SK    
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524

Query: 224  MKTTNLEEMRIAMETYYEEVH-RLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLS 282
                 LE+ + A+ET  EE+  +L+ L    + T    L       + +  M +      
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL-------RLEVNMQALKGQFE 1577

Query: 283  RSVQELTEENQSLKEDLDRVLSTSPT----ISKTQGYVEWSKPRLLRRIVELEKKLSVME 338
            R +Q   E+N+  +  L R L    T      K +     +K +L   + +LE +     
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637

Query: 339  SSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQL--L 396
              +  A + +R      L +     ++   D     + +    ++ +++  +L+  L  L
Sbjct: 1638 KGREEAIKQLRK-----LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1692

Query: 397  QRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEK 455
            Q DL   +  + +ADLEKE E A E       R   L++E + L +++ +L+E  +EE+
Sbjct: 1693 QEDLAAAERARKQADLEKE-ELAEELASSLSGR-NALQDEKRRLEARIAQLEEELEEEQ 1749



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 74/337 (21%), Positives = 135/337 (40%), Gaps = 23/337 (6%)

Query: 138  KKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVIN 197
            KK L     D++L      +  EE  ++ R+++  +      DF R L + R     +  
Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK-----DFQRELEDARASRDEIFA 1673

Query: 198  GLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTG 257
              K+     E++ K  +  + +LQ D+        +  +E        L   LASS +  
Sbjct: 1674 TAKEN----EKKAKSLEADLMQLQEDLAAAERARKQADLEK-----EELAEELASSLSGR 1724

Query: 258  KKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVE 317
                 EK+    R  ++   L     +++ +++  +   +  +++ +   T   T    E
Sbjct: 1725 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1784

Query: 318  WSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERL 377
             ++ +L R+  EL  KL  ME +       V+S   + +A+  A   Q      ++    
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGA-------VKSKFKSTIAALEAKIAQLEEQVEQEAREK 1837

Query: 378  RGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEI 437
            + A + LK++   L+E LLQ + E K   Q K   EK     ++ + +  E EE   + I
Sbjct: 1838 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE-SQRI 1896

Query: 438  QTLTSKLQ-ELQEMKKEEKEDCPEVPHKAQELPAPTP 473
                 KLQ EL E  +  +    EV     +L  P P
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1933



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 70/355 (19%), Positives = 153/355 (43%), Gaps = 54/355 (15%)

Query: 129  DMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEK 188
            D+  +I ELK  L  ++ +   ++  L RL++E ++K+  +++          +R L   
Sbjct: 1073 DLQAQIAELKMQLAKKEEE---LQAALARLDDEIAQKNNALKK----------IRELEGH 1119

Query: 189  RPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMK-----TTNLEEMRIAMETYYEEV 243
              D    ++  +    K E+Q ++    +  L+T+++     T   +E+R   E   +EV
Sbjct: 1120 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE---QEV 1176

Query: 244  HRLQTLLASSETTGKKPLGE-KKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRV 302
              L+  L     + +  + E ++  A+  +++   L    R+   L +  Q+L+++   +
Sbjct: 1177 TVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1236

Query: 303  LSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVR------------- 349
                  + + +  VE  K +L  ++ EL+ K S  E +++   + V              
Sbjct: 1237 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1296

Query: 350  ----------SHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRD 399
                      +   A L+S     ++   +  +    +   +R L+EER +LQ+Q L  +
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-LDEE 1355

Query: 400  LEVKQLLQAK--------ADLEKELECAREGEEERREREEVLREEIQTLTSKLQE 446
            +E KQ L+          +D +K+L+      E   E ++  ++EI+ LT + +E
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1410



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 85/413 (20%), Positives = 171/413 (41%), Gaps = 73/413 (17%)

Query: 120  GTPVYREKEDMYDEIIELKKSLHVQKSDVDLMR-------TKLRRLEEENSRKDRQIEQL 172
            G  +  E++ M  ++++L++ L  +++    ++        K+++LE+E    D Q  +L
Sbjct: 938  GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 997

Query: 173  -----LDPSRGTDFVRTLAEKRPDAS----------WVINGLKQRILKLEQQCKEKDGTI 217
                 L   R +D    LAE+   A            +I+ L+ R+ K E+  +E +   
Sbjct: 998  SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK 1057

Query: 218  SKLQTDMKT---------TNLEEMRIAMETYYEEVH----RLQTLLASSETTGKKPLGEK 264
             KL+ D              + E+++ +    EE+     RL   +A      KK    +
Sbjct: 1058 RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1117

Query: 265  KTGAKRQKKMGS---ALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKP 321
               +  Q+ + S   A     +  ++L EE ++LK +L+  L ++ T  + +   E    
Sbjct: 1118 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE---- 1173

Query: 322  RLLRRIVELEKKLSVMESSKSHAA---EPVRSHPPACLASSSALHRQPRGDRNKDHER-- 376
               + +  L+K L   E ++SH A   E  + H  A    +  L +  R   N D  +  
Sbjct: 1174 ---QEVTVLKKALD--EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1228

Query: 377  -------LRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKAD--------------LEKE 415
                   L G +R L + +  ++ +  + + +V++L    +D              L+ E
Sbjct: 1229 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1288

Query: 416  LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
            +E       E   +   L +++ +L+S+LQ+ QE+ +EE      V  K ++L
Sbjct: 1289 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1341



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 61/274 (22%), Positives = 112/274 (40%), Gaps = 30/274 (10%)

Query: 197  NGLKQRILKLEQQCKEKDGTISKLQTDMKT-TNLEEMRIAMETYYEEV----HRLQTLLA 251
            N LK+   K  Q  +EK+    +LQ + +     EEMR+ +    +E+    H ++  L 
Sbjct: 873  NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 932

Query: 252  SSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISK 311
              E  G++   E+K       KM   +L L   ++E  EE    K  L++V + +  I K
Sbjct: 933  EEEDRGQQLQAERK-------KMAQQMLDLEEQLEE--EEAARQKLQLEKVTAEAK-IKK 982

Query: 312  TQGYV--------EWSKPRLL--RRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
             +  +        + SK R L   RI +L   L+  E    +  +    H          
Sbjct: 983  LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1042

Query: 362  LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
            L ++      K  + L    R L+ + +   EQ+     ++ +L    A  E+EL+ A  
Sbjct: 1043 LKKE-----EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1097

Query: 422  GEEERREREEVLREEIQTLTSKLQELQEMKKEEK 455
              ++   ++    ++I+ L   + +LQE    E+
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 85/388 (21%), Positives = 159/388 (40%), Gaps = 32/388 (8%)

Query: 121  TPVYREKEDMYDEI-IELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGT 179
            T +  + E M  E+ + LKK    +KS  +L + K R+LE + S    QI  L   ++  
Sbjct: 1026 TKLKNKHESMISELEVRLKKE---EKSRQELEKLK-RKLEGDASDFHEQIADL--QAQIA 1079

Query: 180  DFVRTLAEKRPDASWVINGLKQRILKLEQQCK---EKDGTISKLQTDMKTTNLEEMRIAM 236
            +    LA+K  +    +  L   I +     K   E +G IS LQ D+ +      +   
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139

Query: 237  ET--YYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKK---MGSALLSLSRS----VQE 287
            +     EE+  L+T L   E T      +++  AKR+++   +  AL   +RS    VQE
Sbjct: 1140 QKRDLGEELEALKTEL---EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196

Query: 288  LTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEP 347
            + +++    E+L   L       + +  ++ +K  L +   +L  +L V+  +K      
Sbjct: 1197 MRQKHAQAVEELTEQLEQ---FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1250

Query: 348  VRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQ 407
               H    L +     +    D  +    L   V  L+ E  ++   L + + +  +L +
Sbjct: 1251 --EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308

Query: 408  AKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
              A L  +L+  +E  +E   ++  +  +++ L  +   LQ+   EE E    +      
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368

Query: 468  LPAPTPSSRHCEQDWPP--DSSEEGLPR 493
            L      S+   QD+    ++ EEG  R
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKR 1396



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 49/187 (26%), Positives = 79/187 (42%), Gaps = 32/187 (17%)

Query: 269  KRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWS--KPRLLRR 326
            +RQ+K  + L  L +   +LTEE   L+E L          ++T+ Y E    + RL  +
Sbjct: 866  ERQQKAENELKELEQKHSQLTEEKNLLQEQLQ---------AETELYAEAEEMRVRLAAK 916

Query: 327  IVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKE 386
              ELE+ L  ME               A L       +Q + +R K  +++      L+E
Sbjct: 917  KQELEEILHEME---------------ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961

Query: 387  ERTALQEQLLQRDLEVKQLLQAK-ADLEKELECAREGEEERREREEVLREEIQTLTSKLQ 445
            E  A Q+  L+     K   +AK   LE E+    +   +  +  ++L E I  LT+ L 
Sbjct: 962  EEAARQKLQLE-----KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016

Query: 446  ELQEMKK 452
            E +E  K
Sbjct: 1017 EEEEKAK 1023



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 38/178 (21%), Positives = 73/178 (41%), Gaps = 20/178 (11%)

Query: 370  RNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERRER 429
            RN    RL   V+ L +  T  +E++  ++ E+++  + +   E EL+   +   +  E 
Sbjct: 830  RNWQWWRLFTKVKPLLQV-TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE 888

Query: 430  EEVLREEIQT--------------LTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSS 475
            + +L+E++Q               L +K QEL+E+  E +    E   + Q+L A     
Sbjct: 889  KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 948

Query: 476  RHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKVY-----KHKKKKAVLDE 528
                 D      EE   R +        +A  + L+ +  V      K  K++ +L+E
Sbjct: 949  AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 40/222 (18%), Positives = 91/222 (40%), Gaps = 16/222 (7%)

Query: 126  EKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR-GTDFVRT 184
            EKE++ +E+       +  + +   +  ++ +LEEE   +   +E + D  R  T     
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768

Query: 185  LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEE-V 243
            L+ +           +    +LE+Q KE              + L EM  A+++ ++  +
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKE------------LRSKLHEMEGAVKSKFKSTI 1816

Query: 244  HRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVL 303
              L+  +A  E   ++   EK+   K  K+    L  +   V++  +  +  KE  ++  
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1876

Query: 304  STSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAA 345
            +    + +     E    R+     +L+++L   E+++S+ A
Sbjct: 1877 ARVKQLKRQLEEAEEESQRINANRRKLQRELD--EATESNEA 1916


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 83/366 (22%), Positives = 156/366 (42%), Gaps = 48/366 (13%)

Query: 157  RLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILK----LEQQCKE 212
            +LEEE + ++R   +L          R   E+   A       ++R  +    L Q+  E
Sbjct: 1376 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAE 1435

Query: 213  KDGTISKLQT---------DMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGE 263
            K  T+ +L+          D  T +LE+ R  + T  ++  +   LLA  +    + + E
Sbjct: 1436 KTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEE 1495

Query: 264  KKTGAKRQKKMGSALLSLSRSV-------QELTEENQSLKEDLDRVLSTSPTISKTQ--- 313
            ++      ++  +  LSL+R++       +EL  +N++L+ +L+ +LS+   + K+    
Sbjct: 1496 RERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHEL 1555

Query: 314  ----GYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGD 369
                   E +   L  ++ ELE +L+  E +K      V+       A  +   R  +G 
Sbjct: 1556 ERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQ-------ALKTQHERDLQGR 1608

Query: 370  RNKDHERLRGAVRDLKEERTALQEQLLQRDLEV---KQLLQAKADLEKELECAREGEEE- 425
                 ER R   + L++      E+  QR L V   K+L     +L+ ++  A +G+EE 
Sbjct: 1609 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1668

Query: 426  -------RREREEVLREEIQTLTSK---LQELQEMKKEEKEDCPEVPHKAQELPAPTPSS 475
                   + + +E+ RE  +T TS+     + +E +K  K    EV    +EL A   + 
Sbjct: 1669 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1728

Query: 476  RHCEQD 481
            R  +QD
Sbjct: 1729 RQAQQD 1734



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 89/422 (21%), Positives = 164/422 (38%), Gaps = 72/422 (17%)

Query: 119  PGTPVYREKEDMYDEIIELKKSLHVQKS---DVDLMRTKLRRLEEENSRKDRQIEQLLDP 175
            P   V R+ E +     EL+K   +Q+    +V  ++ ++ +LEEE +R   Q+    + 
Sbjct: 868  PLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAEL 927

Query: 176  SRGTDFVR-TLAEKRPDASWVINGLK---------------------QRILKLEQQCKEK 213
                +  R  LA ++ +   V++ L+                     Q I +LE   + +
Sbjct: 928  CAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAE 987

Query: 214  DGTISKLQ-----TDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGA 268
            +G   KLQ     T+ K    EE  + +E    ++ + + LL            E++   
Sbjct: 988  EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKV 1047

Query: 269  KRQKKMG-------SALLSLSRSVQELTEENQSLKEDLDRVLST-SPTISKTQGYVEWSK 320
            K   K+        + +    R  ++  +E + LK  LD   S     + + Q   E  +
Sbjct: 1048 KSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR 1107

Query: 321  PRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALH------------RQPRG 368
             +L R+  EL+  L+  E      A+ ++S   A  A + A               + R 
Sbjct: 1108 AQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1167

Query: 369  DRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLL---------------------- 406
            D  ++ E LRG + D  +   A QE   +R+ EV +L                       
Sbjct: 1168 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1227

Query: 407  QAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQ 466
            QA  +L ++LE AR G+    +    L  E+  L ++L  LQ  ++E ++    +  + Q
Sbjct: 1228 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1287

Query: 467  EL 468
            E+
Sbjct: 1288 EV 1289



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 88/390 (22%), Positives = 152/390 (38%), Gaps = 84/390 (21%)

Query: 156  RRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDG 215
            RR +     +D ++E+  D  R    +   A K+ +    +  LK ++    Q  +E   
Sbjct: 1615 RRRQLAKQLRDAEVER--DEERKQRTLAVAARKKLEGE--LEELKAQMASAGQGKEEAVK 1670

Query: 216  TISKLQTDMKTT--NLEEMRIAMETYYE--------------EVHRLQTLLASSETTGKK 259
             + K+Q  MK     +EE R + E  +               EV RLQ  LA+S+   ++
Sbjct: 1671 QLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQ 1730

Query: 260  PLGEKKTGAKRQKKMG---SALLSLSRSVQ-------ELTEENQSLKEDLD--------R 301
               ++   A          +A+L   R ++       E  EE QS  E L+        +
Sbjct: 1731 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1790

Query: 302  VLSTSPTISKTQGY---VEWSKPRLLRRIVELEKKL---------------SVMESSKSH 343
            V S +  +S  + +    E  + +L R+I EL  +L               + +ES  + 
Sbjct: 1791 VESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQ 1850

Query: 344  AAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTA---LQEQLLQRDL 400
            A E +       + S   + R  +        RL+  V  ++EER     L++QL + +L
Sbjct: 1851 AEEQLEQETRERILSGKLVRRAEK--------RLKEVVLQVEEERRVADQLRDQLEKGNL 1902

Query: 401  EVKQLLQAKADLEKELECAREGE-------EERREREEVLREEIQTLTSKLQE------- 446
             VKQL +   + E+E   A+ G        E+  E  E +  E+ TL ++L+        
Sbjct: 1903 RVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTT 1962

Query: 447  ---LQEMKKEEKEDCPEVPHKAQELPAPTP 473
                Q  + EE     E   +AQ    P+P
Sbjct: 1963 RTVRQVFRLEEGVASDEEAEEAQPGSGPSP 1992



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 94/450 (20%), Positives = 177/450 (39%), Gaps = 65/450 (14%)

Query: 125  REKEDMYDEIIELKKSLHVQKSDV-DLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVR 183
            R++E    E+ +LK+ L  + S++ + M  + +R EE  ++  R+ E+L           
Sbjct: 1069 RKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQ---------A 1119

Query: 184  TLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEV 243
             LA    +      G + ++LK     +E    +++ Q D+++  +   + A +   +  
Sbjct: 1120 ALARAEDEG-----GARAQLLK---SLREAQAALAEAQEDLESERVARTK-AEKQRRDLG 1170

Query: 244  HRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSR-------SVQELTEENQSLK 296
              L+ L    E T      +++  +KR++++     +L         +VQEL + +    
Sbjct: 1171 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL 1230

Query: 297  EDLDRVLSTSPTISKTQGYVEWSKPRLL--RRIVELEKKLSVMESSKSHAAEPVRSHPPA 354
             +L   L  +      +G   W K RL     + EL  +LS +++++    +  R     
Sbjct: 1231 GELAEQLEQA-----RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE-- 1283

Query: 355  CLASSSALHRQPRGDRNKDH--ERLRGAVRDLKEERTALQE------------------- 393
             L       R   G+R +    E+L+ A  +L+    AL E                   
Sbjct: 1284 -LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQL 1342

Query: 394  ----QLLQRDLEVKQLLQAKAD-LEKELECAREGEEERREREEVLREEIQTLTSKLQELQ 448
                +LLQ +   K  L ++   +E E    RE  EE     E    E+QT  ++L E +
Sbjct: 1343 HDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWR 1402

Query: 449  EMKKEEKE--DCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRD-A 505
              ++EE    +  E   +     A   + R  E+    D  E G  R +    D   D  
Sbjct: 1403 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE 1462

Query: 506  AARVLQAQWKVYKHKKKKAVLDEAAVVLQA 535
              R L +  +  + K  + + +E A VL+A
Sbjct: 1463 QQRQLVSTLEKKQRKFDQLLAEEKAAVLRA 1492



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 78/382 (20%), Positives = 159/382 (41%), Gaps = 60/382 (15%)

Query: 127  KEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEE-NSRKDRQIE-----QLLDPSR--- 177
            K+D+   + EL+++  V +   + +R ++  LE+E  + +D ++      Q L       
Sbjct: 1545 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1604

Query: 178  -------GTDFVRTLAEKRPDASWVIN-GLKQRILKLEQQCKEKDGTISKLQTDMKTT-- 227
                   G +  R LA++  DA    +   KQR L +  + K+ +G + +L+  M +   
Sbjct: 1605 LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAAR-KKLEGELEELKAQMASAGQ 1663

Query: 228  -------NLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLS 280
                    L +M+  M+  + EV         + T+ ++   + +   KR K + + +L 
Sbjct: 1664 GKEEAVKQLRKMQAQMKELWREVE-------ETRTSREEIFSQNRESEKRLKGLEAEVLR 1716

Query: 281  LSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELE--------- 331
            L   +       +  ++D D +       + ++  +   K +L  R+ +LE         
Sbjct: 1717 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN 1776

Query: 332  --------KKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRD 383
                    +KL +   S +      RS      +    L RQ +  R +  E   GA   
Sbjct: 1777 SELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR 1836

Query: 384  LKEERTALQEQLLQRDLEVKQ-----LLQAK--ADLEKEL-ECAREGEEERREREEVLRE 435
             K    AL+ +L Q + +++Q     +L  K     EK L E   + EEERR  ++ LR+
Sbjct: 1837 HKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQ-LRD 1895

Query: 436  EIQTLTSKLQELQEMKKEEKED 457
            +++    ++++L+   +E +E+
Sbjct: 1896 QLEKGNLRVKQLKRQLEEAEEE 1917



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 60/315 (19%), Positives = 122/315 (38%), Gaps = 23/315 (7%)

Query: 158  LEEENSRKDRQIEQLLDPSRGTD-FVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGT 216
            LE +N     ++E LL         V  L      A    N L+ ++ +LE +    +  
Sbjct: 1527 LERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDA 1586

Query: 217  ISKLQTD---MKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKK 273
              +L+     +KT +  +++   E   E   +L   L  +E    +   ++      +KK
Sbjct: 1587 KLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKK 1646

Query: 274  MGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKK 333
            +   L  L   +    +  +   + L ++ +    + +       S+  +  +  E EK+
Sbjct: 1647 LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKR 1706

Query: 334  LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
            L  +E+      E         LA+S    RQ + DR++    +   V +    + A+ E
Sbjct: 1707 LKGLEAEVLRLQEE--------LAASDRARRQAQQDRDE----MADEVANGNLSKAAILE 1754

Query: 394  QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
                   E +QL      LE+ELE  +   E   +R   L  ++++LT++L   +    +
Sbjct: 1755 -------EKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAK 1807

Query: 454  EKEDCPEVPHKAQEL 468
             +    ++  + QEL
Sbjct: 1808 AESGRQQLERQIQEL 1822


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 83/366 (22%), Positives = 156/366 (42%), Gaps = 48/366 (13%)

Query: 157  RLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILK----LEQQCKE 212
            +LEEE + ++R   +L          R   E+   A       ++R  +    L Q+  E
Sbjct: 1368 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAE 1427

Query: 213  KDGTISKLQT---------DMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGE 263
            K  T+ +L+          D  T +LE+ R  + T  ++  +   LLA  +    + + E
Sbjct: 1428 KTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEE 1487

Query: 264  KKTGAKRQKKMGSALLSLSRSV-------QELTEENQSLKEDLDRVLSTSPTISKTQ--- 313
            ++      ++  +  LSL+R++       +EL  +N++L+ +L+ +LS+   + K+    
Sbjct: 1488 RERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHEL 1547

Query: 314  ----GYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGD 369
                   E +   L  ++ ELE +L+  E +K      V+       A  +   R  +G 
Sbjct: 1548 ERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQ-------ALKTQHERDLQGR 1600

Query: 370  RNKDHERLRGAVRDLKEERTALQEQLLQRDLEV---KQLLQAKADLEKELECAREGEEE- 425
                 ER R   + L++      E+  QR L V   K+L     +L+ ++  A +G+EE 
Sbjct: 1601 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1660

Query: 426  -------RREREEVLREEIQTLTSK---LQELQEMKKEEKEDCPEVPHKAQELPAPTPSS 475
                   + + +E+ RE  +T TS+     + +E +K  K    EV    +EL A   + 
Sbjct: 1661 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1720

Query: 476  RHCEQD 481
            R  +QD
Sbjct: 1721 RQAQQD 1726



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 89/422 (21%), Positives = 164/422 (38%), Gaps = 72/422 (17%)

Query: 119  PGTPVYREKEDMYDEIIELKKSLHVQKS---DVDLMRTKLRRLEEENSRKDRQIEQLLDP 175
            P   V R+ E +     EL+K   +Q+    +V  ++ ++ +LEEE +R   Q+    + 
Sbjct: 860  PLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAEL 919

Query: 176  SRGTDFVR-TLAEKRPDASWVINGLK---------------------QRILKLEQQCKEK 213
                +  R  LA ++ +   V++ L+                     Q I +LE   + +
Sbjct: 920  CAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAE 979

Query: 214  DGTISKLQ-----TDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGA 268
            +G   KLQ     T+ K    EE  + +E    ++ + + LL            E++   
Sbjct: 980  EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKV 1039

Query: 269  KRQKKMG-------SALLSLSRSVQELTEENQSLKEDLDRVLST-SPTISKTQGYVEWSK 320
            K   K+        + +    R  ++  +E + LK  LD   S     + + Q   E  +
Sbjct: 1040 KSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR 1099

Query: 321  PRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALH------------RQPRG 368
             +L R+  EL+  L+  E      A+ ++S   A  A + A               + R 
Sbjct: 1100 AQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1159

Query: 369  DRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLL---------------------- 406
            D  ++ E LRG + D  +   A QE   +R+ EV +L                       
Sbjct: 1160 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1219

Query: 407  QAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQ 466
            QA  +L ++LE AR G+    +    L  E+  L ++L  LQ  ++E ++    +  + Q
Sbjct: 1220 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1279

Query: 467  EL 468
            E+
Sbjct: 1280 EV 1281



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 88/390 (22%), Positives = 152/390 (38%), Gaps = 84/390 (21%)

Query: 156  RRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDG 215
            RR +     +D ++E+  D  R    +   A K+ +    +  LK ++    Q  +E   
Sbjct: 1607 RRRQLAKQLRDAEVER--DEERKQRTLAVAARKKLEGE--LEELKAQMASAGQGKEEAVK 1662

Query: 216  TISKLQTDMKTT--NLEEMRIAMETYYE--------------EVHRLQTLLASSETTGKK 259
             + K+Q  MK     +EE R + E  +               EV RLQ  LA+S+   ++
Sbjct: 1663 QLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQ 1722

Query: 260  PLGEKKTGAKRQKKMG---SALLSLSRSVQ-------ELTEENQSLKEDLD--------R 301
               ++   A          +A+L   R ++       E  EE QS  E L+        +
Sbjct: 1723 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1782

Query: 302  VLSTSPTISKTQGY---VEWSKPRLLRRIVELEKKL---------------SVMESSKSH 343
            V S +  +S  + +    E  + +L R+I EL  +L               + +ES  + 
Sbjct: 1783 VESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQ 1842

Query: 344  AAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTA---LQEQLLQRDL 400
            A E +       + S   + R  +        RL+  V  ++EER     L++QL + +L
Sbjct: 1843 AEEQLEQETRERILSGKLVRRAEK--------RLKEVVLQVEEERRVADQLRDQLEKGNL 1894

Query: 401  EVKQLLQAKADLEKELECAREGE-------EERREREEVLREEIQTLTSKLQE------- 446
             VKQL +   + E+E   A+ G        E+  E  E +  E+ TL ++L+        
Sbjct: 1895 RVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTT 1954

Query: 447  ---LQEMKKEEKEDCPEVPHKAQELPAPTP 473
                Q  + EE     E   +AQ    P+P
Sbjct: 1955 RTVRQVFRLEEGVASDEEAEEAQPGSGPSP 1984



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 94/450 (20%), Positives = 177/450 (39%), Gaps = 65/450 (14%)

Query: 125  REKEDMYDEIIELKKSLHVQKSDV-DLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVR 183
            R++E    E+ +LK+ L  + S++ + M  + +R EE  ++  R+ E+L           
Sbjct: 1061 RKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQ---------A 1111

Query: 184  TLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEV 243
             LA    +      G + ++LK     +E    +++ Q D+++  +   + A +   +  
Sbjct: 1112 ALARAEDEG-----GARAQLLK---SLREAQAALAEAQEDLESERVARTK-AEKQRRDLG 1162

Query: 244  HRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSR-------SVQELTEENQSLK 296
              L+ L    E T      +++  +KR++++     +L         +VQEL + +    
Sbjct: 1163 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL 1222

Query: 297  EDLDRVLSTSPTISKTQGYVEWSKPRLL--RRIVELEKKLSVMESSKSHAAEPVRSHPPA 354
             +L   L  +      +G   W K RL     + EL  +LS +++++    +  R     
Sbjct: 1223 GELAEQLEQA-----RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE-- 1275

Query: 355  CLASSSALHRQPRGDRNKDH--ERLRGAVRDLKEERTALQE------------------- 393
             L       R   G+R +    E+L+ A  +L+    AL E                   
Sbjct: 1276 -LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQL 1334

Query: 394  ----QLLQRDLEVKQLLQAKAD-LEKELECAREGEEERREREEVLREEIQTLTSKLQELQ 448
                +LLQ +   K  L ++   +E E    RE  EE     E    E+QT  ++L E +
Sbjct: 1335 HDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWR 1394

Query: 449  EMKKEEKE--DCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRD-A 505
              ++EE    +  E   +     A   + R  E+    D  E G  R +    D   D  
Sbjct: 1395 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE 1454

Query: 506  AARVLQAQWKVYKHKKKKAVLDEAAVVLQA 535
              R L +  +  + K  + + +E A VL+A
Sbjct: 1455 QQRQLVSTLEKKQRKFDQLLAEEKAAVLRA 1484



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 78/382 (20%), Positives = 159/382 (41%), Gaps = 60/382 (15%)

Query: 127  KEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEE-NSRKDRQIE-----QLLDPSR--- 177
            K+D+   + EL+++  V +   + +R ++  LE+E  + +D ++      Q L       
Sbjct: 1537 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1596

Query: 178  -------GTDFVRTLAEKRPDASWVIN-GLKQRILKLEQQCKEKDGTISKLQTDMKTT-- 227
                   G +  R LA++  DA    +   KQR L +  + K+ +G + +L+  M +   
Sbjct: 1597 LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAAR-KKLEGELEELKAQMASAGQ 1655

Query: 228  -------NLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLS 280
                    L +M+  M+  + EV         + T+ ++   + +   KR K + + +L 
Sbjct: 1656 GKEEAVKQLRKMQAQMKELWREVE-------ETRTSREEIFSQNRESEKRLKGLEAEVLR 1708

Query: 281  LSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELE--------- 331
            L   +       +  ++D D +       + ++  +   K +L  R+ +LE         
Sbjct: 1709 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN 1768

Query: 332  --------KKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRD 383
                    +KL +   S +      RS      +    L RQ +  R +  E   GA   
Sbjct: 1769 SELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR 1828

Query: 384  LKEERTALQEQLLQRDLEVKQ-----LLQAK--ADLEKEL-ECAREGEEERREREEVLRE 435
             K    AL+ +L Q + +++Q     +L  K     EK L E   + EEERR  ++ LR+
Sbjct: 1829 HKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQ-LRD 1887

Query: 436  EIQTLTSKLQELQEMKKEEKED 457
            +++    ++++L+   +E +E+
Sbjct: 1888 QLEKGNLRVKQLKRQLEEAEEE 1909



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 60/315 (19%), Positives = 122/315 (38%), Gaps = 23/315 (7%)

Query: 158  LEEENSRKDRQIEQLLDPSRGTD-FVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGT 216
            LE +N     ++E LL         V  L      A    N L+ ++ +LE +    +  
Sbjct: 1519 LERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDA 1578

Query: 217  ISKLQTD---MKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKK 273
              +L+     +KT +  +++   E   E   +L   L  +E    +   ++      +KK
Sbjct: 1579 KLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKK 1638

Query: 274  MGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKK 333
            +   L  L   +    +  +   + L ++ +    + +       S+  +  +  E EK+
Sbjct: 1639 LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKR 1698

Query: 334  LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
            L  +E+      E         LA+S    RQ + DR++    +   V +    + A+ E
Sbjct: 1699 LKGLEAEVLRLQEE--------LAASDRARRQAQQDRDE----MADEVANGNLSKAAILE 1746

Query: 394  QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
                   E +QL      LE+ELE  +   E   +R   L  ++++LT++L   +    +
Sbjct: 1747 -------EKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAK 1799

Query: 454  EKEDCPEVPHKAQEL 468
             +    ++  + QEL
Sbjct: 1800 AESGRQQLERQIQEL 1814


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 83/366 (22%), Positives = 156/366 (42%), Gaps = 48/366 (13%)

Query: 157  RLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILK----LEQQCKE 212
            +LEEE + ++R   +L          R   E+   A       ++R  +    L Q+  E
Sbjct: 1409 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAE 1468

Query: 213  KDGTISKLQT---------DMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGE 263
            K  T+ +L+          D  T +LE+ R  + T  ++  +   LLA  +    + + E
Sbjct: 1469 KTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEE 1528

Query: 264  KKTGAKRQKKMGSALLSLSRSV-------QELTEENQSLKEDLDRVLSTSPTISKTQ--- 313
            ++      ++  +  LSL+R++       +EL  +N++L+ +L+ +LS+   + K+    
Sbjct: 1529 RERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHEL 1588

Query: 314  ----GYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGD 369
                   E +   L  ++ ELE +L+  E +K      V+       A  +   R  +G 
Sbjct: 1589 ERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQ-------ALKTQHERDLQGR 1641

Query: 370  RNKDHERLRGAVRDLKEERTALQEQLLQRDLEV---KQLLQAKADLEKELECAREGEEE- 425
                 ER R   + L++      E+  QR L V   K+L     +L+ ++  A +G+EE 
Sbjct: 1642 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1701

Query: 426  -------RREREEVLREEIQTLTSK---LQELQEMKKEEKEDCPEVPHKAQELPAPTPSS 475
                   + + +E+ RE  +T TS+     + +E +K  K    EV    +EL A   + 
Sbjct: 1702 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1761

Query: 476  RHCEQD 481
            R  +QD
Sbjct: 1762 RQAQQD 1767



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 89/422 (21%), Positives = 164/422 (38%), Gaps = 72/422 (17%)

Query: 119  PGTPVYREKEDMYDEIIELKKSLHVQKS---DVDLMRTKLRRLEEENSRKDRQIEQLLDP 175
            P   V R+ E +     EL+K   +Q+    +V  ++ ++ +LEEE +R   Q+    + 
Sbjct: 901  PLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAEL 960

Query: 176  SRGTDFVR-TLAEKRPDASWVINGLK---------------------QRILKLEQQCKEK 213
                +  R  LA ++ +   V++ L+                     Q I +LE   + +
Sbjct: 961  CAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAE 1020

Query: 214  DGTISKLQ-----TDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGA 268
            +G   KLQ     T+ K    EE  + +E    ++ + + LL            E++   
Sbjct: 1021 EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKV 1080

Query: 269  KRQKKMG-------SALLSLSRSVQELTEENQSLKEDLDRVLST-SPTISKTQGYVEWSK 320
            K   K+        + +    R  ++  +E + LK  LD   S     + + Q   E  +
Sbjct: 1081 KSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR 1140

Query: 321  PRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALH------------RQPRG 368
             +L R+  EL+  L+  E      A+ ++S   A  A + A               + R 
Sbjct: 1141 AQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1200

Query: 369  DRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLL---------------------- 406
            D  ++ E LRG + D  +   A QE   +R+ EV +L                       
Sbjct: 1201 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1260

Query: 407  QAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQ 466
            QA  +L ++LE AR G+    +    L  E+  L ++L  LQ  ++E ++    +  + Q
Sbjct: 1261 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1320

Query: 467  EL 468
            E+
Sbjct: 1321 EV 1322



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 88/390 (22%), Positives = 152/390 (38%), Gaps = 84/390 (21%)

Query: 156  RRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDG 215
            RR +     +D ++E+  D  R    +   A K+ +    +  LK ++    Q  +E   
Sbjct: 1648 RRRQLAKQLRDAEVER--DEERKQRTLAVAARKKLEGE--LEELKAQMASAGQGKEEAVK 1703

Query: 216  TISKLQTDMKTT--NLEEMRIAMETYYE--------------EVHRLQTLLASSETTGKK 259
             + K+Q  MK     +EE R + E  +               EV RLQ  LA+S+   ++
Sbjct: 1704 QLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQ 1763

Query: 260  PLGEKKTGAKRQKKMG---SALLSLSRSVQ-------ELTEENQSLKEDLD--------R 301
               ++   A          +A+L   R ++       E  EE QS  E L+        +
Sbjct: 1764 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1823

Query: 302  VLSTSPTISKTQGY---VEWSKPRLLRRIVELEKKL---------------SVMESSKSH 343
            V S +  +S  + +    E  + +L R+I EL  +L               + +ES  + 
Sbjct: 1824 VESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQ 1883

Query: 344  AAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTA---LQEQLLQRDL 400
            A E +       + S   + R  +        RL+  V  ++EER     L++QL + +L
Sbjct: 1884 AEEQLEQETRERILSGKLVRRAEK--------RLKEVVLQVEEERRVADQLRDQLEKGNL 1935

Query: 401  EVKQLLQAKADLEKELECAREGE-------EERREREEVLREEIQTLTSKLQE------- 446
             VKQL +   + E+E   A+ G        E+  E  E +  E+ TL ++L+        
Sbjct: 1936 RVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTT 1995

Query: 447  ---LQEMKKEEKEDCPEVPHKAQELPAPTP 473
                Q  + EE     E   +AQ    P+P
Sbjct: 1996 RTVRQVFRLEEGVASDEEAEEAQPGSGPSP 2025



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 94/450 (20%), Positives = 177/450 (39%), Gaps = 65/450 (14%)

Query: 125  REKEDMYDEIIELKKSLHVQKSDV-DLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVR 183
            R++E    E+ +LK+ L  + S++ + M  + +R EE  ++  R+ E+L           
Sbjct: 1102 RKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQ---------A 1152

Query: 184  TLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEV 243
             LA    +      G + ++LK     +E    +++ Q D+++  +   + A +   +  
Sbjct: 1153 ALARAEDEG-----GARAQLLK---SLREAQAALAEAQEDLESERVARTK-AEKQRRDLG 1203

Query: 244  HRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSR-------SVQELTEENQSLK 296
              L+ L    E T      +++  +KR++++     +L         +VQEL + +    
Sbjct: 1204 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL 1263

Query: 297  EDLDRVLSTSPTISKTQGYVEWSKPRLL--RRIVELEKKLSVMESSKSHAAEPVRSHPPA 354
             +L   L  +      +G   W K RL     + EL  +LS +++++    +  R     
Sbjct: 1264 GELAEQLEQA-----RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE-- 1316

Query: 355  CLASSSALHRQPRGDRNKDH--ERLRGAVRDLKEERTALQE------------------- 393
             L       R   G+R +    E+L+ A  +L+    AL E                   
Sbjct: 1317 -LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQL 1375

Query: 394  ----QLLQRDLEVKQLLQAKAD-LEKELECAREGEEERREREEVLREEIQTLTSKLQELQ 448
                +LLQ +   K  L ++   +E E    RE  EE     E    E+QT  ++L E +
Sbjct: 1376 HDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWR 1435

Query: 449  EMKKEEKE--DCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRD-A 505
              ++EE    +  E   +     A   + R  E+    D  E G  R +    D   D  
Sbjct: 1436 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE 1495

Query: 506  AARVLQAQWKVYKHKKKKAVLDEAAVVLQA 535
              R L +  +  + K  + + +E A VL+A
Sbjct: 1496 QQRQLVSTLEKKQRKFDQLLAEEKAAVLRA 1525



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 78/382 (20%), Positives = 159/382 (41%), Gaps = 60/382 (15%)

Query: 127  KEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEE-NSRKDRQIE-----QLLDPSR--- 177
            K+D+   + EL+++  V +   + +R ++  LE+E  + +D ++      Q L       
Sbjct: 1578 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1637

Query: 178  -------GTDFVRTLAEKRPDASWVIN-GLKQRILKLEQQCKEKDGTISKLQTDMKTT-- 227
                   G +  R LA++  DA    +   KQR L +  + K+ +G + +L+  M +   
Sbjct: 1638 LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAAR-KKLEGELEELKAQMASAGQ 1696

Query: 228  -------NLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLS 280
                    L +M+  M+  + EV         + T+ ++   + +   KR K + + +L 
Sbjct: 1697 GKEEAVKQLRKMQAQMKELWREVE-------ETRTSREEIFSQNRESEKRLKGLEAEVLR 1749

Query: 281  LSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELE--------- 331
            L   +       +  ++D D +       + ++  +   K +L  R+ +LE         
Sbjct: 1750 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN 1809

Query: 332  --------KKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRD 383
                    +KL +   S +      RS      +    L RQ +  R +  E   GA   
Sbjct: 1810 SELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR 1869

Query: 384  LKEERTALQEQLLQRDLEVKQ-----LLQAK--ADLEKEL-ECAREGEEERREREEVLRE 435
             K    AL+ +L Q + +++Q     +L  K     EK L E   + EEERR  ++ LR+
Sbjct: 1870 HKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQ-LRD 1928

Query: 436  EIQTLTSKLQELQEMKKEEKED 457
            +++    ++++L+   +E +E+
Sbjct: 1929 QLEKGNLRVKQLKRQLEEAEEE 1950



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 60/315 (19%), Positives = 122/315 (38%), Gaps = 23/315 (7%)

Query: 158  LEEENSRKDRQIEQLLDPSRGTD-FVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGT 216
            LE +N     ++E LL         V  L      A    N L+ ++ +LE +    +  
Sbjct: 1560 LERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDA 1619

Query: 217  ISKLQTD---MKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKK 273
              +L+     +KT +  +++   E   E   +L   L  +E    +   ++      +KK
Sbjct: 1620 KLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKK 1679

Query: 274  MGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKK 333
            +   L  L   +    +  +   + L ++ +    + +       S+  +  +  E EK+
Sbjct: 1680 LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKR 1739

Query: 334  LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
            L  +E+      E         LA+S    RQ + DR++    +   V +    + A+ E
Sbjct: 1740 LKGLEAEVLRLQEE--------LAASDRARRQAQQDRDE----MADEVANGNLSKAAILE 1787

Query: 394  QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
                   E +QL      LE+ELE  +   E   +R   L  ++++LT++L   +    +
Sbjct: 1788 -------EKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAK 1840

Query: 454  EKEDCPEVPHKAQEL 468
             +    ++  + QEL
Sbjct: 1841 AESGRQQLERQIQEL 1855


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 81/394 (20%), Positives = 170/394 (43%), Gaps = 39/394 (9%)

Query: 125  REKEDMYDEIIELKKSLHVQKSDVDLMRTKLR-RLEEENSRK---DRQIEQL-------- 172
            ++ +++  E    K SL  +   V+  +   R +LEEE   K   ++QI  L        
Sbjct: 1311 QDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMK 1370

Query: 173  --LDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKT--TN 228
              ++ S G   + T  E +      + GL QR  +      + + T ++LQ ++     +
Sbjct: 1371 KKMEDSVGC--LETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVD 1428

Query: 229  LEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQEL 288
            L+  R +     ++  +   LLA  +T   K   E+       ++  +  LSL+R+++E 
Sbjct: 1429 LDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEA 1488

Query: 289  TEE-------NQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSK 341
             E+       N+  + +++ ++S+   + K+   +E SK  L +++ E++ +L  +E   
Sbjct: 1489 MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL 1548

Query: 342  SHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLE 401
                +          A  +   R  +G   +  E+ +  VR ++E    L+++  QR + 
Sbjct: 1549 QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMA 1608

Query: 402  V---KQLLQAKADLEKELECAREGEEE--------RREREEVLREEIQTLTSK---LQEL 447
            V   K+L     DLE  ++ A +  +E        + + ++ +RE   T  S+   L + 
Sbjct: 1609 VAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQA 1668

Query: 448  QEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQD 481
            +E +K+ K    E+    +EL A   + R  +Q+
Sbjct: 1669 KENEKKLKSMEAEMIQLQEELAAAERAKRQAQQE 1702



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 69/341 (20%), Positives = 134/341 (39%), Gaps = 56/341 (16%)

Query: 119  PGTPVYREKEDMY---DEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDP 175
            P   V R++E+M    +E++++++     ++ +  M T   +L  E  +   Q++   + 
Sbjct: 836  PLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETEL 895

Query: 176  SRGTDFVRT-LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRI 234
                + +R  L  K+ +   + + L+ R+ + E++C+       K+Q             
Sbjct: 896  CAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQ------------- 942

Query: 235  AMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQS 294
                  + +  L+  L   E+  +K   EK T   + KK+               EE Q 
Sbjct: 943  ------QNIQELEEQLEEEESARQKLQLEKVTTEAKLKKL---------------EEEQI 981

Query: 295  LKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPA 354
            + ED +  L+               K  L  RI E    L+  E      A+    H   
Sbjct: 982  ILEDQNCKLAKE-------------KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM 1028

Query: 355  CLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEK 414
                   L R+      K  + L    R L+ + T L +Q+ +   ++ +L    A  E+
Sbjct: 1029 ITDLEERLRRE-----EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEE 1083

Query: 415  ELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEK 455
            EL+ A    EE   ++ +  ++I+ L S++ ELQE  + E+
Sbjct: 1084 ELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 77/354 (21%), Positives = 158/354 (44%), Gaps = 33/354 (9%)

Query: 199  LKQRILKLEQQCKEKDGTISKLQ-----TDMKTTNLEEMRIAMETYY----EEVHRLQTL 249
            ++Q I +LE+Q +E++    KLQ     T+ K   LEE +I +E       +E   L+  
Sbjct: 941  MQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDR 1000

Query: 250  LASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRV----LST 305
            +A   T   +   + K+ AK + K  + +  L   ++   ++ Q L++   ++       
Sbjct: 1001 IAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDL 1060

Query: 306  SPTISKTQGYVEWSKPRLLRRIVELEKKLSVME---SSKSHAAEPVRSHPPACLASSSAL 362
            S  I++ Q  +   K +L ++  EL+  L+ +E   + K+ A + +R            L
Sbjct: 1061 SDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDL 1120

Query: 363  HRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREG 422
              + R  RNK  ++ R    DL EE  AL+ +L       +  L + A  ++EL   RE 
Sbjct: 1121 ESE-RASRNKAEKQKR----DLGEELEALKTEL-------EDTLDSTA-AQQELRSKRE- 1166

Query: 423  EEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQDW 482
             +E    ++ L EE +T  +++QE+++   +  E+  E   + + + A    ++   ++ 
Sbjct: 1167 -QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE 1225

Query: 483  PPDSSEE--GLPRPRSPCSDGRRDAAARVLQAQWKVYKHKKKKAVLDEAAVVLQ 534
              + + E   L + +      R+   A++ + Q K  + ++ +  L +    LQ
Sbjct: 1226 RGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQ 1279



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 68/354 (19%), Positives = 153/354 (43%), Gaps = 35/354 (9%)

Query: 126  EKEDMYDEIIELKKSLHVQKSDV----DLMRTKLRRLEEENSRKDRQIEQLLD-PSRGTD 180
            +  D+ D+I EL+  +   K  +    + ++  L R+EEE ++K+  ++++ +  S+ ++
Sbjct: 1056 DSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE 1115

Query: 181  FVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMK-----TTNLEEMRIA 235
                L  +R   +           K E+Q ++    +  L+T+++     T   +E+R  
Sbjct: 1116 LQEDLESERASRN-----------KAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSK 1164

Query: 236  METYYEEVHRLQTLLASSETTGKKPLGE-KKTGAKRQKKMGSALLSLSRSVQELTEENQS 294
             E   +EV+ L+  L     T +  + E ++  ++  +++   L    R    L +  Q+
Sbjct: 1165 RE---QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT 1221

Query: 295  LKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPA 354
            L+ +   + +    + + +G  E  + ++  ++ EL+ K +  E  ++  A+ V      
Sbjct: 1222 LENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVE 1281

Query: 355  CLASSSALHRQPRGDRN--KDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADL 412
                +  L +         KD   L   ++D +E       Q L    ++KQ       +
Sbjct: 1282 LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQ-------V 1334

Query: 413  EKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQ 466
            E E    RE  EE  E +  L ++I TL +++ ++++ K E+   C E   + +
Sbjct: 1335 EDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKK-KMEDSVGCLETAEEVK 1387



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 65/373 (17%), Positives = 151/373 (40%), Gaps = 42/373 (11%)

Query: 127  KEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEE-NSRKDRQIE-----QLLDPSRGTD 180
            K+D+   + EL+KS    +  V+ M+T+L  LE+E  + +D ++      Q +      D
Sbjct: 1513 KDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERD 1572

Query: 181  FVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTIS---KLQTDMK--TTNLEEMRIA 235
                  +       ++  +++   +LE + K++   ++   KL+ D+K    +++     
Sbjct: 1573 LQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN 1632

Query: 236  METYYEEVHRLQTL-------LASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQEL 288
             +   +++ +LQ         L  +  + ++ L + K   K+ K M + ++ L   +   
Sbjct: 1633 RDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAA 1692

Query: 289  TEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPV 348
                +  +++ D +       S         K RL  RI +LE++L   + +     + +
Sbjct: 1693 ERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRL 1752

Query: 349  -----------------RSHPPACLASSSALHRQPRGDRNKDHE-------RLRGAVRDL 384
                             RSH      +   L RQ +  + K  E       + + ++  L
Sbjct: 1753 KKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITAL 1812

Query: 385  KEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKL 444
            + +   L+EQL     E +   +     EK+L+      ++ R   E  +++    +++L
Sbjct: 1813 EAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRL 1872

Query: 445  QELQEMKKEEKED 457
            ++L+   +E +E+
Sbjct: 1873 KQLKRQLEEAEEE 1885



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 29/100 (29%), Positives = 51/100 (51%), Gaps = 5/100 (5%)

Query: 372 KDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREG-EEERRERE 430
           K  E+   A   L E  T LQ QL+   L++++ LQA+ +L  E E  R     +++E E
Sbjct: 856 KVREKQLAAENRLTEMET-LQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELE 914

Query: 431 EV---LREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
           E+   L   ++    + Q LQ  KK+ +++  E+  + +E
Sbjct: 915 EICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE 954



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 19/85 (22%), Positives = 42/85 (49%)

Query: 384 LKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSK 443
           ++E++ A + +L + +    QL+  K  L+++L+   E   E  E    L  + Q L   
Sbjct: 857 VREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEI 916

Query: 444 LQELQEMKKEEKEDCPEVPHKAQEL 468
             +L+   +EE+E C  +  + +++
Sbjct: 917 CHDLEARVEEEEERCQHLQAEKKKM 941


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
           sapiens]
          Length = 1116

 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 77/363 (21%), Positives = 155/363 (42%), Gaps = 41/363 (11%)

Query: 125 REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
           R+KE     + E  KSL    ++ D   T L  LEE  + K+R IE+L +  R  D  R 
Sbjct: 588 RDKEKQMSSLKERVKSLQADTTNTD---TALTTLEEALAEKERTIERLKE-QRDRD-ERE 642

Query: 185 LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTD---------MKTTNLEEMRIA 235
             E+  +    +  LK+++  L+    EK+ ++  L+            K + L+ + IA
Sbjct: 643 KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIA 702

Query: 236 METYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSL 295
           +E   EE  ++++ L        K   E    A+   +M   +  L R +    +E+   
Sbjct: 703 LEQKKEECLKMESQL--------KKAHEAALEARASPEMSDRIQHLEREITRYKDESSKA 754

Query: 296 KEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPAC 355
           + ++DR+L     +   +   +     L R++ +  KK++ ++       E V     A 
Sbjct: 755 QAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK-----EQVEKKKSAQ 809

Query: 356 LASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQL-------LQRDLEVKQLLQA 408
           +   +   R+   + N   ++L+ ++R   +    L+E L        +R++ + Q   A
Sbjct: 810 MLEEA---RRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESA 866

Query: 409 KADLEKELECAREGEEERREREEVLREEI----QTLTSKLQELQEMKKEEKEDCPEVPHK 464
           + + EK++E      E+ ++  E ++ ++    Q+L  K   L  ++ E ++   EV   
Sbjct: 867 RTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEM 926

Query: 465 AQE 467
            QE
Sbjct: 927 KQE 929



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 77/356 (21%), Positives = 161/356 (45%), Gaps = 35/356 (9%)

Query: 136 ELKKSLHVQK---SDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEK---- 188
           ELKK   ++K   S + + + + R ++EEN      I+ L D  R    +  L ++    
Sbjct: 193 ELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSS 252

Query: 189 RPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVH-RLQ 247
           R     V    ++   +L  + + +   +  L+       LEEM + +ET  + ++ R +
Sbjct: 253 RTGEPCVAELTEENFQRLHAEHERQAKELFLLRK-----TLEEMELRIETQKQTLNARDE 307

Query: 248 TLLASSETTGKKPLGEKKTGA--KRQKKMGSALLS---LSRSVQELTEENQSLKEDLDRV 302
           ++    E    K L  K T    +R +++  A +    L   +++  +EN  L+E++ R 
Sbjct: 308 SIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRR 367

Query: 303 LSTSPTISKTQGYVEWSKPRLLRRIVEL-EKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
              +P  +KT         + L+ ++E+ + K+S ME       E ++      L S+ A
Sbjct: 368 FENAPDSAKT---------KALQTVIEMKDSKISSMERGLRDLEEEIQ-----MLKSNGA 413

Query: 362 LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
           L  + R +  K  E  R   + +K +   L+E+L  ++ + ++L +  A L+ E+   ++
Sbjct: 414 LSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQ 473

Query: 422 GEEERREREEV-LREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSR 476
            E  R++ E + L+ +++TLT++  + ++  +  KE       +A  L     + R
Sbjct: 474 -ELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALR 528



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 78/366 (21%), Positives = 161/366 (43%), Gaps = 36/366 (9%)

Query: 143 VQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF--VRTLAEKRPDASWVINGLK 200
           + +++VD +R +L   E   ++K +QI+ + +  +GT    +  L +        +N L+
Sbjct: 519 ILQTEVDALRLRLEEKETMLNKKTKQIQDMAE-EKGTQAGEIHDLKDMLDVKERKVNVLQ 577

Query: 201 QRILKLEQQCKEKDGTISKLQTDMK-----TTNLEEMRIAMETYYEEVHRLQTLLASSET 255
           ++I  L++Q ++K+  +S L+  +K     TTN +     +E    E  R    L     
Sbjct: 578 KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRD 637

Query: 256 TGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGY 315
             ++   E+    K+  K     +SL +   +L+E+  SL +  +   S +     + G 
Sbjct: 638 RDEREKQEEIDNYKKDLKDLKEKVSLLQG--DLSEKEASLLDLKEHASSLA-----SSGL 690

Query: 316 VEWSKPRLLRRIVELEKKLSV-MESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDH 374
            + S+ + L   +E +K+  + MES    A E       +   S    H +    R KD 
Sbjct: 691 KKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDE 750

Query: 375 --------ERLRGAVRDLKEERTALQEQLLQRDLEVKQL------LQAKADLEKE----- 415
                   +RL   +++++ E+    +++ + + +VK        L+ K  +EK+     
Sbjct: 751 SSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM 810

Query: 416 LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPH-KAQELPAPTPS 474
           LE AR  E+   +  + L++ ++    +++EL+E  +E  +   E     AQE  A T +
Sbjct: 811 LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA 870

Query: 475 SRHCEQ 480
            +  E+
Sbjct: 871 EKQVEE 876



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 82/396 (20%), Positives = 161/396 (40%), Gaps = 58/396 (14%)

Query: 132 DEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF---------- 181
           +E  E  K + V +S    M+ K+ +L+EE S K+ Q E+L   + G             
Sbjct: 417 EEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELS 476

Query: 182 ------------VRTLAEKRPDASWVINGLKQRILKLEQQC----KEKDGTISKLQ---- 221
                       + TL  +  D+   I  LK+ +   EQ+      E D    +L+    
Sbjct: 477 RKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKET 536

Query: 222 -TDMKTTNLEEMRIAMETYYEEVHRLQTLLASSE---TTGKKPLGEKKTGAKRQKKMGSA 277
             + KT  +++M     T   E+H L+ +L   E      +K +   +   + ++K  S+
Sbjct: 537 MLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSS 596

Query: 278 LLSLSRSVQELTEENQSLKEDLDRVLS----TSPTISKTQGYVEWSKPRLL----RRIVE 329
           L    +S+Q  T    +    L+  L+    T   + + +   E  K   +    + + +
Sbjct: 597 LKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKD 656

Query: 330 LEKKLSVME---SSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKE 386
           L++K+S+++   S K  +   ++ H  A   +SS L +  R       + L  A+   KE
Sbjct: 657 LKEKVSLLQGDLSEKEASLLDLKEH--ASSLASSGLKKDSR------LKTLEIALEQKKE 708

Query: 387 ERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREE--VLREEIQTLTSKL 444
           E   ++ QL +     +  L+A+A  E          E  R ++E    + E+  L   L
Sbjct: 709 ECLKMESQLKKAH---EAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEIL 765

Query: 445 QELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQ 480
           +E++  K ++ +   E+  + ++      + +H EQ
Sbjct: 766 KEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQ 801



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 46/188 (24%), Positives = 82/188 (43%), Gaps = 31/188 (16%)

Query: 131 YDEIIELKKS---LHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAE 187
           + E +E KKS   L   +   D +    ++L++   +KD +IE+L +  R  + V+  AE
Sbjct: 798 HKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALR--ESVQITAE 855

Query: 188 K----------RPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDM--KTTNLEEMRIA 235
           +          R +A   +  L   + K++Q+ +     +S  Q  +  K T+L  +R  
Sbjct: 856 REMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE 915

Query: 236 METYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSL 295
              + EEV  ++               E    A  +K    ALL LS S ++  EE  +L
Sbjct: 916 RRKHLEEVLEMKQ--------------EALLAAISEKDANIALLELSSSKKKTQEEVAAL 961

Query: 296 KEDLDRVL 303
           K + DR++
Sbjct: 962 KREKDRLV 969


>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
          Length = 1088

 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 77/363 (21%), Positives = 155/363 (42%), Gaps = 41/363 (11%)

Query: 125 REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
           R+KE     + E  KSL    ++ D   T L  LEE  + K+R IE+L +  R  D  R 
Sbjct: 560 RDKEKQMSSLKERVKSLQADTTNTD---TALTTLEEALAEKERTIERLKE-QRDRD-ERE 614

Query: 185 LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTD---------MKTTNLEEMRIA 235
             E+  +    +  LK+++  L+    EK+ ++  L+            K + L+ + IA
Sbjct: 615 KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIA 674

Query: 236 METYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSL 295
           +E   EE  ++++ L        K   E    A+   +M   +  L R +    +E+   
Sbjct: 675 LEQKKEECLKMESQL--------KKAHEAALEARASPEMSDRIQHLEREITRYKDESSKA 726

Query: 296 KEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPAC 355
           + ++DR+L     +   +   +     L R++ +  KK++ ++       E V     A 
Sbjct: 727 QAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK-----EQVEKKKSAQ 781

Query: 356 LASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQL-------LQRDLEVKQLLQA 408
           +   +   R+   + N   ++L+ ++R   +    L+E L        +R++ + Q   A
Sbjct: 782 MLEEA---RRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESA 838

Query: 409 KADLEKELECAREGEEERREREEVLREEI----QTLTSKLQELQEMKKEEKEDCPEVPHK 464
           + + EK++E      E+ ++  E ++ ++    Q+L  K   L  ++ E ++   EV   
Sbjct: 839 RTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEM 898

Query: 465 AQE 467
            QE
Sbjct: 899 KQE 901



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 75/349 (21%), Positives = 156/349 (44%), Gaps = 43/349 (12%)

Query: 136 ELKKSLHVQK---SDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEK---- 188
           ELKK   ++K   S + + + + R ++EEN      I+ L D  R    +  L ++    
Sbjct: 193 ELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSS 252

Query: 189 RPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVH-RLQ 247
           R     V    ++   +L  + + +   +  L+       LEEM + +ET  + ++ R +
Sbjct: 253 RTGEPCVAELTEENFQRLHAEHERQAKELFLLRK-----TLEEMELRIETQKQTLNARDE 307

Query: 248 TLLASSETTGKKPLGEKKTGA--KRQKKMGSALLS---LSRSVQELTEENQSLKEDLDRV 302
           ++    E    K L  K T    +R +++  A +    L   +++  +EN  L+E++ R 
Sbjct: 308 SIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRR 367

Query: 303 LSTSPTISKTQGYVEWSKPRLLRRIVEL-EKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
              +P  +KT         + L+ ++E+ + K+S ME       E ++      L S+ A
Sbjct: 368 FENAPDSAKT---------KALQTVIEMKDSKISSMERGLRDLEEEIQ-----MLKSNGA 413

Query: 362 LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLE-------VKQLLQAKADLEK 414
           L  + R +  K  E  R   + +K +   ++++L ++D E       ++ L    +D ++
Sbjct: 414 LSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQ 473

Query: 415 ELECAREGEEERREREEVLREEIQTLTSKLQELQEM---KKEEKEDCPE 460
            +E  +E    + +R  +L+ E+  L  +L+E + M   K ++ +D  E
Sbjct: 474 HIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAE 522



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 78/366 (21%), Positives = 161/366 (43%), Gaps = 36/366 (9%)

Query: 143 VQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF--VRTLAEKRPDASWVINGLK 200
           + +++VD +R +L   E   ++K +QI+ + +  +GT    +  L +        +N L+
Sbjct: 491 ILQTEVDALRLRLEEKETMLNKKTKQIQDMAE-EKGTQAGEIHDLKDMLDVKERKVNVLQ 549

Query: 201 QRILKLEQQCKEKDGTISKLQTDMK-----TTNLEEMRIAMETYYEEVHRLQTLLASSET 255
           ++I  L++Q ++K+  +S L+  +K     TTN +     +E    E  R    L     
Sbjct: 550 KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRD 609

Query: 256 TGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGY 315
             ++   E+    K+  K     +SL +   +L+E+  SL +  +   S +     + G 
Sbjct: 610 RDEREKQEEIDNYKKDLKDLKEKVSLLQG--DLSEKEASLLDLKEHASSLA-----SSGL 662

Query: 316 VEWSKPRLLRRIVELEKKLSV-MESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDH 374
            + S+ + L   +E +K+  + MES    A E       +   S    H +    R KD 
Sbjct: 663 KKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDE 722

Query: 375 --------ERLRGAVRDLKEERTALQEQLLQRDLEVKQL------LQAKADLEKE----- 415
                   +RL   +++++ E+    +++ + + +VK        L+ K  +EK+     
Sbjct: 723 SSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM 782

Query: 416 LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPH-KAQELPAPTPS 474
           LE AR  E+   +  + L++ ++    +++EL+E  +E  +   E     AQE  A T +
Sbjct: 783 LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA 842

Query: 475 SRHCEQ 480
            +  E+
Sbjct: 843 EKQVEE 848



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 46/188 (24%), Positives = 82/188 (43%), Gaps = 31/188 (16%)

Query: 131 YDEIIELKKS---LHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAE 187
           + E +E KKS   L   +   D +    ++L++   +KD +IE+L +  R  + V+  AE
Sbjct: 770 HKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALR--ESVQITAE 827

Query: 188 K----------RPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDM--KTTNLEEMRIA 235
           +          R +A   +  L   + K++Q+ +     +S  Q  +  K T+L  +R  
Sbjct: 828 REMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE 887

Query: 236 METYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSL 295
              + EEV  ++               E    A  +K    ALL LS S ++  EE  +L
Sbjct: 888 RRKHLEEVLEMKQ--------------EALLAAISEKDANIALLELSSSKKKTQEEVAAL 933

Query: 296 KEDLDRVL 303
           K + DR++
Sbjct: 934 KREKDRLV 941


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 81/429 (18%), Positives = 178/429 (41%), Gaps = 49/429 (11%)

Query: 118 VPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR 177
           +P   +  E + +  E+  +   L  Q  + +L     ++ EE+  R++ +I++  +   
Sbjct: 258 LPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEK-- 315

Query: 178 GTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAME 237
               ++   EK  +    I   ++++ + E+   EK+  + + Q +M     E+MR   E
Sbjct: 316 ----IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR-QEEMMWEKEEKMRRLEE 370

Query: 238 TYYEEVHRLQTLLASSETTGKKPLGEKKTGA----KRQKKMGSALLSLSRSVQELTEENQ 293
             +E+  +++ L        K    E+K       + Q+K       + R  +++ E+ +
Sbjct: 371 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 430

Query: 294 SLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMES-----SKSHAAEPV 348
            ++E   ++      I + +   E  K +    +   E+K+   E       K H  E +
Sbjct: 431 KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKI 490

Query: 349 RSHPPACLASSSALHRQPRGDRNKDH-------------ERLRGAVRDLKEERTALQEQL 395
           R            +H Q    R ++              E++R     ++E+   +QEQ 
Sbjct: 491 RKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQE 550

Query: 396 LQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTL---TSKLQELQEMKK 452
            ++  E ++ +Q +  + ++ E  RE EE+ RE++E +RE+ + +     K++E +EM +
Sbjct: 551 -EKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQ 609

Query: 453 EEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVLQA 512
           E++E   E   K             CEQ+      EE + R      +   +   R+ Q 
Sbjct: 610 EQEEKMWEQEEKM------------CEQEEKMQEQEEKMRRQ----EEKMWEQEVRLRQQ 653

Query: 513 QWKVYKHKK 521
           + K+ +H++
Sbjct: 654 EEKMQEHQE 662



 Score = 33.1 bits (74), Expect = 0.87
 Identities = 48/176 (27%), Positives = 70/176 (39%), Gaps = 55/176 (31%)

Query: 329 ELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEER 388
           ELE+ LS + + K  A   +        A S  L+R    D             +LKE+ 
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDE------------ELKEKN 223

Query: 389 TALQEQL----------------LQRDLE------VKQLLQAKAD-LEKELECA------ 419
             LQE+L                L+R LE       +Q LQA+AD L KEL+        
Sbjct: 224 AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA 283

Query: 420 -----------REGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHK 464
                       + +EE+  R+E   E+IQ    K+QE +E  +E++E   E   K
Sbjct: 284 QVEENELWNRLNQQQEEKMWRQE---EKIQEWEEKIQEQEEKIREQEEKIREQEEK 336


>gi|50083293 coiled-coil domain containing 123 [Homo sapiens]
          Length = 783

 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 73/318 (22%), Positives = 140/318 (44%), Gaps = 35/318 (11%)

Query: 125 REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
           ++ +++ DE   LK ++H    ++   +TK R L +E S     IE L  PS+G      
Sbjct: 306 KQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLN---IEGL--PSKG------ 354

Query: 185 LAEKRPDASWV--INGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEE 242
                P   W+  I  L   +L  E   KEKD   + L+ +M+   +    +  E   EE
Sbjct: 355 -----PIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKEN--EE 407

Query: 243 VHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRV 302
           +H  Q L  SS  T ++   + +T AK   +    LL      ++L  + +  K+     
Sbjct: 408 LH--QELNKSSAVTSEE-WRQLQTQAKLVLEENKLLL------EQLEIQQRKAKDSHQER 458

Query: 303 LSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASS--S 360
           L     ++K    +E       + + E  ++L ++ +      + +++H    +A     
Sbjct: 459 LQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAK----CQELKTHSDGKIAVEVHK 514

Query: 361 ALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR 420
           ++  + +    K+ E+ R  + +L E+ T LQ Q     LE   L +    LE ELE A+
Sbjct: 515 SIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQ 574

Query: 421 EGEEERREREEVLREEIQ 438
           +   + +++ EVL+++++
Sbjct: 575 KINRKSQKKIEVLKKQVE 592



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 73/348 (20%), Positives = 148/348 (42%), Gaps = 48/348 (13%)

Query: 123 VYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFV 182
           V +E E+++ E   L KS  V   +   ++T+ + + EEN     Q+E            
Sbjct: 401 VVKENEELHQE---LNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQ--------- 448

Query: 183 RTLAEKRPDASWVINGLKQRILKLEQQC--KEKDGTISKLQTDMKTTNLEEMR------I 234
           R   +   +    ++ L ++++ LE +   +EK+   ++ Q ++     +E++      I
Sbjct: 449 RKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKI 508

Query: 235 AMETYYEEVHRLQTLLASSETTGK---KPLGEKKTGAKRQKKMGSALLSLSRSVQELTEE 291
           A+E +   V+ L++ L   E   +   + L EK T  + QKK      SL      LTE+
Sbjct: 509 AVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKK------SLLLEKNSLTEQ 562

Query: 292 NQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSH 351
           N++L+ +L+R    +    K+Q  +E  K ++  + +  E       ++    AE +   
Sbjct: 563 NKALEAELERAQKIN---RKSQKKIEVLKKQV-EKAMGNEMSAHQYLANLVGLAENITQE 618

Query: 352 PPACLASSSALHRQPRGDRNKDHE------RLRGAVRDLKEERTALQEQLLQRDLEVKQL 405
             + +  +  L  +  G  NK  +      +L   V+  K++       +  R LE ++ 
Sbjct: 619 RDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQED 678

Query: 406 LQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
              K           +  +E R   +VL+++ + L   LQ+ +EM+ E
Sbjct: 679 FAGKT---------AQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGE 717



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 65/298 (21%), Positives = 126/298 (42%), Gaps = 25/298 (8%)

Query: 185 LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVH 244
           L EK P +  +    +QR  ++    +EK   + +   D+   N + + + + T  + + 
Sbjct: 214 LCEKPPPSPDITGRARQRYTEIT---REKFEALKEENMDLNNMN-QSLTLELNTMKQAMK 269

Query: 245 RLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRV-- 302
            LQ  L   E   +K    +K  A  Q+     LL L +  QEL +EN  LK  + R+  
Sbjct: 270 ELQLKLKGMEKEKRKLKEAEK--ASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNV 327

Query: 303 -LSTSPT----ISKTQGY-VEW--SKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPA 354
            LS   T    +SK +   +E   SK  +   +++++    ++ + +    E  +    A
Sbjct: 328 ELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKE--KDELNA 385

Query: 355 CLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEK 414
            L     + R    +  K++E L    ++L +      E+  Q   + K +L+    L +
Sbjct: 386 TLKEEMRMFRMRVQEVVKENEELH---QELNKSSAVTSEEWRQLQTQAKLVLEENKLLLE 442

Query: 415 ELEC----AREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
           +LE     A++  +ER +    L +++  L +K    ++   E +E    +  K QEL
Sbjct: 443 QLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQEL 500


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 86/359 (23%), Positives = 147/359 (40%), Gaps = 74/359 (20%)

Query: 133 EIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDA 192
           EI ++K     ++S  +    K+ RL EE +++   I+ L          +T   +RP  
Sbjct: 171 EIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDL----------KTELLQRPGI 220

Query: 193 SWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLAS 252
             V       +LK E         + ++QT M    LE  R + E   +E  +LQ+  AS
Sbjct: 221 EDVA------VLKKE---------LVQVQTLMDNMTLERERES-EKLKDECKKLQSQYAS 264

Query: 253 SETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKT 312
           SE T  +   E   G +        L  L  SV ELT++NQ+L E+L         + K 
Sbjct: 265 SEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL---------LKKE 315

Query: 313 QGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPAC-------LASSSALHR- 364
           Q Y             +LE+K +    SK +    +      C        AS ++LHR 
Sbjct: 316 QDY------------TKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRI 363

Query: 365 ----QPRGDRNK-----------DHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAK 409
                 +G+  +            ++ L+   + L+++R   ++  LQ   E+ QL    
Sbjct: 364 HVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL 423

Query: 410 ADLEKEL-ECAREGEEERREREEVL---REEIQTLTSKLQELQEMKKEEKEDCPEVPHK 464
            + E++L E     +E+R+   E L    +++  L  KL  L+E  KE+  +  E+ H+
Sbjct: 424 LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 75/344 (21%), Positives = 150/344 (43%), Gaps = 41/344 (11%)

Query: 161  ENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQ---RILKLEQQCKEKDGTI 217
            +N+ +D+Q E     ++       L +K+   S + + LK+   + L LEQ+ +E +G I
Sbjct: 673  QNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI 732

Query: 218  SKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQ--KKMG 275
             KL+ D       + +   +   +        L ++E + +  + ++   + R   +K  
Sbjct: 733  KKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKS 792

Query: 276  SALLSLSRSVQELTEENQSLKEDLDRVLSTSP------------TISKTQGYVEWSKPRL 323
             AL S+ + + +  EE Q LK+D + +   +             T+++ Q  V+  K  L
Sbjct: 793  EALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK-VKMEKEAL 851

Query: 324  LRRIVELEKKLS-VMESSKSHAAEPVRSHPPA----------CLASSSALHRQPRG---- 368
            +  +  ++ KLS V +S K+  +E  + +             C      L  Q       
Sbjct: 852  MTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE 911

Query: 369  --DRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEER 426
              +  K  E+ + A   LK E  ++QEQL+Q    +KQ  + +  L+  +   ++  E++
Sbjct: 912  QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK 971

Query: 427  REREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPA 470
            +++ E L+ E+     K+  LQ+ + E K    ++   AQEL A
Sbjct: 972  KKQIEALQGEL-----KIAVLQKTELENKLQ-QQLTQAAQELAA 1009



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 79/366 (21%), Positives = 148/366 (40%), Gaps = 43/366 (11%)

Query: 126 EKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGT--DFVR 183
           E E  Y  +    K L  Q+ + +    +L+    +   K  + E+ L  + G   +  +
Sbjct: 383 EVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQ 442

Query: 184 TLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEV 243
             +EK  D    +  L+ ++ +LE+Q KEK    ++LQ  +  T  +         ++E 
Sbjct: 443 LSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ---------HQEQ 493

Query: 244 HRLQTLLASSETTGKKPLGE--KKTGAKRQKKMG-SALLSLSRSVQELTEENQSLKEDLD 300
             LQ    +     +  L +  ++ G K QK     ALL  S+    L E+    +EDL 
Sbjct: 494 QALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKE---REDLY 550

Query: 301 RVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSS 360
             +      +     ++     L  ++ +L +KL     S   A E +            
Sbjct: 551 AKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQ-----VQEQ 605

Query: 361 ALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQ----LLQA-------K 409
             H +   DR      L  +V +L  +    +E++ Q D+++K     LL A       +
Sbjct: 606 KAHLRAAQDRVLS---LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQR 662

Query: 410 ADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQE-------MKKEEKEDCPEVP 462
           ADL+  L+ A+   +++++    +  ++  +T+KLQ+ QE         KE KE    + 
Sbjct: 663 ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLE 722

Query: 463 HKAQEL 468
            K +EL
Sbjct: 723 QKTEEL 728



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 78/385 (20%), Positives = 161/385 (41%), Gaps = 56/385 (14%)

Query: 126  EKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEE------------------------ 161
            + E+   E  ELKKSL  +K     ++ +L  ++E+                        
Sbjct: 904  QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE 963

Query: 162  ----NSRKDRQIEQL-----LDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKE 212
                + +K +QIE L     +   + T+    L ++   A+  +   K++I  L+   ++
Sbjct: 964  LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEK 1023

Query: 213  KDGTISKLQTDM--KTTNLEEMRIAMETYYEEVHRLQTLLASSET---TGKKPLGEKKTG 267
               T  +LQ+D   + + L   R  +++  E++   Q  L S+        K + E KT 
Sbjct: 1024 SQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKT- 1082

Query: 268  AKRQKKMGSALLSLSRSVQELTEENQSLKE-DLDRVLSTSPTISKTQ--GYVEWSKPRLL 324
            AK   +  SA     +  Q+L E  ++L++   ++ L     +++      +E  K R  
Sbjct: 1083 AKATLEQDSA-----KKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQE 1137

Query: 325  RRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDL 384
            + I +L ++L      KSH  E ++      L  +  L  Q + +     + L+ AV   
Sbjct: 1138 KEITKLNEEL------KSHKLESIKE--ITNLKDAKQLLIQQKLELQGKADSLKAAVEQE 1189

Query: 385  KEERTALQEQLLQRDLEV-KQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSK 443
            K  +  L++Q+ + + E+ K+ ++ +A L  E++    G ++  E E  L  +I  L   
Sbjct: 1190 KRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNEN 1249

Query: 444  LQELQEMKKEEKEDCPEVPHKAQEL 468
            L  +++  +  +    E+  +  +L
Sbjct: 1250 LGTVKKEWQSSQRRVSELEKQTDDL 1274



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 67/320 (20%), Positives = 140/320 (43%), Gaps = 48/320 (15%)

Query: 200  KQRILKLEQQCKEKDGTISKLQTDMKTTNLE--EMRIAMETYYEEVHRLQTLLASSETTG 257
            K  IL LE+ CKE      +LQ  M+ T  E  E++ ++E   E  H+L+  L S +   
Sbjct: 884  KAAILDLEKTCKELK---HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL 940

Query: 258  KKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLD-RVLSTSPTISKTQGYV 316
             +     K   K ++++   +  L +S ++  ++ ++L+ +L   VL  +   +K Q  +
Sbjct: 941  IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000

Query: 317  EWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSAL-------------- 362
              +   L       ++K+SV++++   + E  +          S L              
Sbjct: 1001 TQAAQELAAE----KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKL 1056

Query: 363  ---------HRQPRGDRNKDHERLRGAV-----------RDLKEERTALQEQLLQRDLEV 402
                     +R   G++NK  + L+ A            + L+E   ALQ+   ++ L+ 
Sbjct: 1057 SLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKE 1116

Query: 403  KQLLQAKADLE--KELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPE 460
            K+L+  K+ L   +E++C R+ +E  +  EE+   +++++  ++  L++ K+   +   E
Sbjct: 1117 KELVNEKSKLAEIEEIKC-RQEKEITKLNEELKSHKLESI-KEITNLKDAKQLLIQQKLE 1174

Query: 461  VPHKAQELPAPTPSSRHCEQ 480
            +  KA  L A     +  +Q
Sbjct: 1175 LQGKADSLKAAVEQEKRNQQ 1194



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 44/177 (24%), Positives = 83/177 (46%), Gaps = 41/177 (23%)

Query: 123  VYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFV 182
            V +E+E++  E IE +  LH   S++      +++ EE  ++   QI  L + + GT   
Sbjct: 1200 VKKEEEELKKEFIEKEAKLH---SEIKEKEVGMKKHEENEAKLTMQITAL-NENLGT--- 1252

Query: 183  RTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE- 241
                +K   +S      ++R+ +LE+Q  +  G I+ L+  ++  N +E R  +E   + 
Sbjct: 1253 ---VKKEWQSS------QRRVSELEKQTDDLRGEIAVLEATVQN-NQDERRALLERCLKG 1302

Query: 242  --EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLK 296
              E+ +LQT +                  + Q+K+ +     + +VQEL  ENQSL+
Sbjct: 1303 EGEIEKLQTKVL-----------------ELQRKLDNT----TAAVQELGRENQSLQ 1338


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 106/523 (20%), Positives = 201/523 (38%), Gaps = 86/523 (16%)

Query: 22  PPPTSPKSPYLSKPRKVASWRSLRTAGSMPLGGRASLTPQKLWLGTAKPGSLTQALNSPL 81
           P P  P  P+L     + +   L T   +P     S   ++  L  AK           L
Sbjct: 5   PQPHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPMMSKETRQSKLAEAK---------EQL 55

Query: 82  TWEHAWTGVPGGTPDCLTDTFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSL 141
           T  H  T    GT    T   ++       + ++G        ++    + E   L++ L
Sbjct: 56  TDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQKASHQHQEA--LRREL 113

Query: 142 HVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVING-LK 200
             Q   + ++  +   L+         ++QL   +R  D +  L +     SW   G L+
Sbjct: 114 EAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEAR--DLISRLHD-----SWKFAGELE 166

Query: 201 QRILKLEQQCKEKDGTISKLQTDMKTTNLEEMR--IAMETYYEEVHRLQT---LLASSET 255
           Q +  +  Q K+ D  I +L  +    +LE  R  I  E   E+  +LQ    L+ S ++
Sbjct: 167 QALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKS 226

Query: 256 TGKKPLGEKKTGAKRQK-------------KMGSALLSLSRSVQELTEENQ--------- 293
             +  + E K   +R K              +G  L S+S  +Q   EEN+         
Sbjct: 227 EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQ 286

Query: 294 ---------SLKEDLDRVLSTSPTIS------KTQGYVEWSKPRLLRRIVEL----EKKL 334
                     ++E  +++      I       + Q  + W K   +RR  E+    E+K+
Sbjct: 287 EEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI 346

Query: 335 SVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRN----KDHERLRGAVRDLKEERTA 390
             +E  K H  E +R              ++ R ++     +  E++R     ++E+   
Sbjct: 347 RELEE-KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEM 405

Query: 391 LQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEM 450
           +QEQ  +   + +++ + + +++++ E  R  EE+ RE+E+ +RE+      K++E +EM
Sbjct: 406 MQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQ----EEKIREQEEM 461

Query: 451 KKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPR 493
            +E++E   E               + CEQ+      EE + R
Sbjct: 462 MQEQEEKMGE------------QEGKMCEQEAKMQEQEEKMRR 492



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 69/379 (18%), Positives = 158/379 (41%), Gaps = 32/379 (8%)

Query: 151 MRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQC 210
           ++ KL+ +E E S     +++L         +    + + +A  +   L+    KL+ Q 
Sbjct: 214 LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQV 273

Query: 211 KEKD--GTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGA 268
           +E +    +++ Q +      E+++   E   E+  +++          ++ + EK+   
Sbjct: 274 EENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQ-EEMMWEKEEKM 332

Query: 269 KRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVE----WSKPRLL 324
           +RQ++M        R ++E   E + ++E  ++         + +   +    W +   +
Sbjct: 333 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI 392

Query: 325 R----RIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGA 380
           R    +I E E+ +   E       E +             + RQ    R ++ +++R  
Sbjct: 393 REQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQE-KKIREQ 451

Query: 381 VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTL 440
              ++E+   +QEQ  +   +  ++ + +A ++++ E  R  EE+ RE+E+ +RE+    
Sbjct: 452 EEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQ---- 507

Query: 441 TSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSD 500
             K++E +EM +E++E   E   K             CEQ+      EE + R      +
Sbjct: 508 EEKIREQEEMMQEQEEKMWEQEEKM------------CEQEEKMQEQEEKMRRQ----EE 551

Query: 501 GRRDAAARVLQAQWKVYKH 519
             R+   R+ Q + K+ +H
Sbjct: 552 KMREQEVRLRQQEEKMQEH 570


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 88/444 (19%), Positives = 182/444 (40%), Gaps = 36/444 (8%)

Query: 110  RRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQI 169
            ++S    H       + +ED  + +I++   L  Q  D++    + ++L  +  R  R++
Sbjct: 1000 KKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKL 1059

Query: 170  EQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQ-QCKEKDGTISKLQTDMKTTN 228
            E  L  S+      ++ +   D   +   LK++  +L Q Q K  D  +  LQ   K   
Sbjct: 1060 EGDLKMSQ-----ESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKK--- 1111

Query: 229  LEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQEL 288
            ++E++  +E   EE+    TL A  E        E +  ++R ++   A  +     ++ 
Sbjct: 1112 IKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKR 1171

Query: 289  TEENQSLKEDLDRVL----STSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHA 344
              E Q ++ DL+       +T+ T+ K Q          +  +  +++KL   +S     
Sbjct: 1172 EAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKME 1231

Query: 345  AEPVRSHPPACLASSSALHRQPRGDRN-------KDHERLRGAVRDLKEERTALQEQ--- 394
             + + S+  A   S S + R  R   +       KD ++ +  + DL  ++  LQ Q   
Sbjct: 1232 IDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQ-LIHDLNMQKARLQTQNGE 1290

Query: 395  ----LLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEM 450
                + +++  + QL ++K  L ++LE  +   EE  + +  +   +Q+       L+E 
Sbjct: 1291 LSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQ 1350

Query: 451  KKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVL 510
             +EE+E       KA+   A + ++    Q W      + + R      + ++  A R+ 
Sbjct: 1351 YEEEQE------AKAELQRALSKANSEVAQ-WRTKYETDAIQRTEE-LEEAKKKLAQRLQ 1402

Query: 511  QAQWKVYKHKKKKAVLDEAAVVLQ 534
            +A+        K A L++    LQ
Sbjct: 1403 EAEENTETANSKCASLEKTKQRLQ 1426



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 65/299 (21%), Positives = 123/299 (41%), Gaps = 48/299 (16%)

Query: 200  KQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKK 259
            K+ + + E + KE +  +  L  +     L+ ++   E   +   R + L+ S      K
Sbjct: 864  KEELARSEARRKELEEKMVSLLQEKNDLQLQ-VQSETENLMDAEERCEGLIKSKILLEAK 922

Query: 260  PLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWS 319
             + E     + +++M S L++  R++++   +  SLK D+D +  T   + K +   E  
Sbjct: 923  -VKELTERLEEEEEMNSELVAKKRNLED---KCSSLKRDIDDLELTLTKVEKEKHATENK 978

Query: 320  KPRLLRRIVELEKKLSVMESSKSHAAEPVR-----------------------SHPPACL 356
               L   +  LE+ +S +   K    E  +                             L
Sbjct: 979  VKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDL 1038

Query: 357  ASSSALHRQPRGDRNKDHERLRG-------AVRDLKEERTALQEQLLQRDLEVKQLLQAK 409
              S    ++ R D  +   +L G       ++ DL+ ++  ++E+L +++ E+ Q LQAK
Sbjct: 1039 EGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQ-LQAK 1097

Query: 410  ADLE-----------KELECAREGEEERREREEVLREEIQTLTSKL-QELQEMKKEEKE 456
             D E           KEL+   E  EE  E E  LR +I+   S L +EL+E+ +  +E
Sbjct: 1098 IDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEE 1156



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 73/404 (18%), Positives = 157/404 (38%), Gaps = 86/404 (21%)

Query: 128  EDMYDEIIELKKSLHVQKSDVDLMRTK-----LRRLEEENSRKDRQIEQLLDPSRGTDFV 182
            E+  +   EL+++L    S+V   RTK     ++R EE    K +  ++L +    T+  
Sbjct: 1352 EEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETA 1411

Query: 183  RTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEE 242
             +                 +   LE+  +   G +  L  D     LE    A  T  ++
Sbjct: 1412 NS-----------------KCASLEKTKQRLQGEVEDLMRD-----LERSHTACATLDKK 1449

Query: 243  VHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTE-------ENQSL 295
                  +LA  +    +   E +   K  + + + L  +  + +E+ +       EN++L
Sbjct: 1450 QRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNL 1509

Query: 296  KEDL----DRVLSTSPTIS---KTQGYVEWS----------------------------- 319
            +E++    +++  T   +    KT+  VE                               
Sbjct: 1510 QEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLEL 1569

Query: 320  ---KPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSS---ALHRQPRGDRNKD 373
               K  L R+++E ++++  ++ +   AAE ++S   A + S +    L ++  GD N+ 
Sbjct: 1570 SQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEM 1629

Query: 374  HERLRGAVRDLKEERTAL---QEQLLQRDLEVKQLLQAKADLEKELECAREGEEERRERE 430
              +L  + R + E +  L   Q QL    L +   L++  DL+++L            R 
Sbjct: 1630 EIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIV-------ERRN 1682

Query: 431  EVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPS 474
             +L EE++ +   L++ +  ++  +++  +   + Q L +   S
Sbjct: 1683 GLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTS 1726



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 73/389 (18%), Positives = 168/389 (43%), Gaps = 47/389 (12%)

Query: 109  LRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQ 168
            L R     H     + +++ +    + E K+ L   +++++  + + R L  E  +    
Sbjct: 1432 LMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNA 1491

Query: 169  IEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGT---ISKLQTDMK 225
             E+++D       + TL  +  +    I+ L ++I +  +  +E + T   + + ++D++
Sbjct: 1492 YEEVVDQ------LETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQ 1545

Query: 226  TTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSV 285
               LEE+  ++E    ++ R+Q  L+  ++   + + EK    ++ K+         +SV
Sbjct: 1546 VA-LEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSV 1604

Query: 286  --QELTEENQSLK------EDLD-----------RVLSTSPTISKTQGYVEWSKPRL--- 323
               E+   N +L+       DL+           ++  T   +   QG ++ S+  L   
Sbjct: 1605 LDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDA 1664

Query: 324  LRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGA--V 381
            LR   +L+++L+++E       E +            AL +  R  R  + E L  +  V
Sbjct: 1665 LRSNEDLKEQLAIVERRNGLLLEELEE-------MKVALEQTERTRRLSEQELLDASDRV 1717

Query: 382  RDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERRER---EEVLREEIQ 438
            + L  + T+L     ++ LE   + Q +A++E  ++ +R  EE+ ++      ++ EE++
Sbjct: 1718 QLLHSQNTSLINT--KKKLEA-DIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELK 1774

Query: 439  TLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
                    L+ MKK  ++   ++ H+  E
Sbjct: 1775 KEQDTSAHLERMKKNLEQTVKDLQHRLDE 1803



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 75/360 (20%), Positives = 147/360 (40%), Gaps = 50/360 (13%)

Query: 126  EKEDMYDEIIELKKSLHVQKSD----VDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF 181
            E  +  D +  +K+ L  +KS+    +D M + +  L +  S  +R    + D       
Sbjct: 1206 ELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSE--- 1262

Query: 182  VRTLAEKRPDASWVINGLKQRIL----KLEQQCKEKDGTISKLQTDMK--TTNLEEMRIA 235
            ++   E++      +N  K R+     +L  + +EK+  IS+L    +  T  LEE++  
Sbjct: 1263 IKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQ 1322

Query: 236  METYYEE----VHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSR-------- 283
            ME   +      H LQ+     +   ++   E++  A+ Q+ +  A   +++        
Sbjct: 1323 MEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETD 1382

Query: 284  ---SVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESS 340
                 +EL E  + L + L      + T +     +E +K RL   + +L + L      
Sbjct: 1383 AIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLE----- 1437

Query: 341  KSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDL 400
                    RSH  AC    + L ++ R + +K     +  + + + E  A Q++      
Sbjct: 1438 --------RSHT-AC----ATLDKKQR-NFDKVLAEWKQKLDESQAELEAAQKESRSLST 1483

Query: 401  EVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKK---EEKED 457
            E+ ++  A  ++  +LE  R   +  +E    L E+I      LQE ++ KK   +EK D
Sbjct: 1484 ELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSD 1543



 Score = 36.6 bits (83), Expect = 0.078
 Identities = 28/97 (28%), Positives = 49/97 (50%), Gaps = 7/97 (7%)

Query: 372 KDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREE 431
           +D ER +  +   +  R  L+E+++        LLQ K DL+ +++   E   +  ER E
Sbjct: 858 EDFERTKEELARSEARRKELEEKMVS-------LLQEKNDLQLQVQSETENLMDAEERCE 910

Query: 432 VLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
            L +    L +K++EL E  +EE+E   E+  K + L
Sbjct: 911 GLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNL 947


>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
           sapiens]
          Length = 1478

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 78/363 (21%), Positives = 159/363 (43%), Gaps = 36/363 (9%)

Query: 199 LKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE------EVHRLQTLLAS 252
           L++R+ +L+++ +E    +S+ Q +   T  E  R A E          E+ +   +  +
Sbjct: 249 LRERMQQLDRENQELRAAVSQ-QGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQA 307

Query: 253 SETTGKKPL----GEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRV---LST 305
           ++ T K+      G +   A++++   +AL  L   +Q L +E ++ ++ LD+    L++
Sbjct: 308 TQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLAS 367

Query: 306 SP-----------TISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPA 354
            P           T S T+G  E       + + EL +KL  +E  ++   E  R    +
Sbjct: 368 FPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQ--S 425

Query: 355 CLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEK 414
                     Q + D     ERL   +  L+EE +   ++  Q    +++LL   +  E+
Sbjct: 426 AQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEE 485

Query: 415 ELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPS 474
           EL   R  +++++E +E+L +E+++LT +LQ L+    +  +   ++  + ++L      
Sbjct: 486 ELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQL---IQD 542

Query: 475 SRHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARV---LQAQWKVYKHKKK---KAVLDE 528
             H  Q         G P P  P +  + +A   V   LQ  W   + +++   +A LD+
Sbjct: 543 KDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDD 602

Query: 529 AAV 531
             V
Sbjct: 603 TKV 605



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 58/300 (19%), Positives = 134/300 (44%), Gaps = 34/300 (11%)

Query: 159 EEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTIS 218
           ++ ++  D +  Q   PS     ++ L EK       +  L++   K+E+  +++   + 
Sbjct: 377 QKADTASDTKGRQEPIPSDAAQEMQELGEK-------LQALERERTKVEEVNRQQSAQLE 429

Query: 219 KLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSAL 278
           +L  +++    E+ R ++E   +E+  LQ      E +GK    ++    +R +++ +  
Sbjct: 430 QLVKELQLK--EDARASLERLVKEMAPLQ-----EELSGKGQEADQLW--RRLQELLAHT 480

Query: 279 LSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVME 338
            S    + EL  E +  +E+ + +     ++++   ++E    ++ + + +LE++   + 
Sbjct: 481 SSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLI 540

Query: 339 SSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDL----KEERTALQEQ 394
             K H ++ V       LA          G++N+    +  ++++     +EE+  LQE 
Sbjct: 541 QDKDHLSQQVGMLER--LAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEA 598

Query: 395 LL-----QRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQE 449
            L     Q   + ++L QA  +LEKEL       +    R ++L  ++Q L +  Q LQ+
Sbjct: 599 QLDDTKVQEGSQEEELRQANRELEKEL-------QNVVGRNQLLEGKLQALQADYQALQQ 651



 Score = 33.1 bits (74), Expect = 0.87
 Identities = 62/305 (20%), Positives = 116/305 (38%), Gaps = 60/305 (19%)

Query: 199 LKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGK 258
           +K ++ + E   + K+G   +L+ ++     E+ +   E  + E+  L+     S+   +
Sbjct: 691 MKAQMAEKEAILQSKEGECQQLREEV-----EQCQQLAEARHRELRALE-----SQCQQQ 740

Query: 259 KPLGEKKTGAKRQKKMG----------SALLSLSRS--------VQELTEENQSLKEDLD 300
             L E  T  K Q+ +G          +A L+LS++        VQ L  +   L+  + 
Sbjct: 741 TQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMR 800

Query: 301 RVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESS--KSHAAEPVRSHPPACLAS 358
             L     +       E     +LR    L ++L     +  ++H  E ++     C   
Sbjct: 801 AALDDQDKVQSQLSMAE----AVLREHKTLVQQLKEQNEALNRAHVQELLQ-----CSER 851

Query: 359 SSALHRQPRGDRNKDHERLRGAVRDLKE----------ERTALQEQLLQRD-------LE 401
             AL  +   +  +  E LR    +L +          E   LQEQL + +       ++
Sbjct: 852 EGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQ 911

Query: 402 VKQLLQAKADLEKELECA----REGEEERREREEVLREEIQTLTSKLQELQEMKKEEKED 457
           V  L   K  +E+ L CA    ++ +E      E L  ++  L  + + LQE  K  K  
Sbjct: 912 VCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAA 971

Query: 458 CPEVP 462
              +P
Sbjct: 972 AGSLP 976


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 77/360 (21%), Positives = 159/360 (44%), Gaps = 43/360 (11%)

Query: 126  EKEDMYDEIIELKKSLHVQ----KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF 181
            ++E+M  E+   K+ L  +    K D+D +   L ++E+E    + +++ L +   G D 
Sbjct: 928  DEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDE 987

Query: 182  V--------RTLAEKRPDA-------SWVINGLKQRILKLEQQCKEKDGTIS---KLQTD 223
            +        + L E    A          +N L +  +KLEQQ  + +G++    K++ D
Sbjct: 988  IIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMD 1047

Query: 224  MKTTNLE---EMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAK--RQKKMGSAL 278
            ++    +   ++++  E+  +  +  Q L    E   KK        A+   ++ +GS  
Sbjct: 1048 LERAKRKLEGDLKLTQESIMDLENDKQQL---DERLKKKDFELNALNARIEDEQALGS-- 1102

Query: 279  LSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSV-M 337
              L + ++EL    + L+E+L+   +    + K +  +      +  R+ E     SV +
Sbjct: 1103 -QLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQI 1161

Query: 338  ESSKSHAAE---PVRSHPPACL---ASSSAL---HRQPRGDRNKDHERLRGAVRDLKEER 388
            E +K   AE     R    A L   A+++AL   H     +  +  + L+   + L++E+
Sbjct: 1162 EMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEK 1221

Query: 389  TALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQ 448
            +  + +L      ++Q+++AKA+LEK      +   E R + E  +  +  LTS+  +LQ
Sbjct: 1222 SEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ 1281



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 76/369 (20%), Positives = 149/369 (40%), Gaps = 34/369 (9%)

Query: 110  RRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVD--LMRTKLRRLEEENSRKDR 167
            +++    H       + +ED  + + + K  L  Q  D++  L + K  R++ E +++  
Sbjct: 996  KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKL 1055

Query: 168  QIEQLLDPSRGTDFV---RTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDM 224
            + +  L      D     + L E+     + +N L  RI       +++    S+LQ  +
Sbjct: 1056 EGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARI-------EDEQALGSQLQKKL 1108

Query: 225  KTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRS 284
            K     E++  +E   EE+   +T  A  E        E +  ++R ++ G A       
Sbjct: 1109 K-----ELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEM 1163

Query: 285  VQELTEENQSLKEDLDRV-LSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSH 343
             ++   E Q ++ DL+   L    T +  +     S   L  +I  L++    +E  KS 
Sbjct: 1164 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1223

Query: 344  ---AAEPVRSHPPACLASSSALHRQPRG--DRNKDH----ERLRGAVRDLKEERTALQ-- 392
                 + V S+    + + + L +  R   D+  +H    E  + +V DL  +R  LQ  
Sbjct: 1224 FKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283

Query: 393  -----EQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQEL 447
                  QL +++  + QL + K    ++LE  +   EE  + +  L   +Q+       L
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343

Query: 448  QEMKKEEKE 456
            +E  +EE E
Sbjct: 1344 REQYEEETE 1352



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 55/325 (16%), Positives = 139/325 (42%), Gaps = 25/325 (7%)

Query: 132  DEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPD 191
            +E + +KK +    +++++  +   R+  E  ++ + ++ LL  ++          +  D
Sbjct: 1609 NEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ---------IQLDD 1659

Query: 192  ASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLA 251
            A    + LK+ I  +E++       + +L+  ++ T     ++A +   E   R+Q L +
Sbjct: 1660 AVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTE-RSRKLAEQELIETSERVQLLHS 1718

Query: 252  SSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISK 311
             + +              ++KKM + L  L   V+E  +E ++ +E   + ++ +  +++
Sbjct: 1719 QNTSL-----------INQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAE 1767

Query: 312  TQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRN 371
                 + +   L R    +E+ +  ++     A +         L    A  R+   +  
Sbjct: 1768 ELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELE 1827

Query: 372  KDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREE 431
             + +R   +V+ +++    ++E   Q + + K LL+ + DL  +L+   +  + + E  E
Sbjct: 1828 AEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQ-DLVDKLQLKVKAYKRQAEEAE 1886

Query: 432  VLREEIQTLTSKLQELQEMKKEEKE 456
               E+  T  SK +++Q    E +E
Sbjct: 1887 ---EQANTNLSKFRKVQHELDEAEE 1908



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 68/363 (18%), Positives = 134/363 (36%), Gaps = 55/363 (15%)

Query: 125  REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
            +E   +  E+ +LK +       ++  + + + L+EE S     + + L  S  T  +  
Sbjct: 1472 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS----DLTEQLGSSGKT--IHE 1525

Query: 185  LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLE----------EMRI 234
            L + R         L+  + + E   + ++G I + Q +      E          EM  
Sbjct: 1526 LEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 1585

Query: 235  AMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQS 294
            A   +   V  LQT L +   +  + L  KK       +M   L   +R   E  ++ +S
Sbjct: 1586 AKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKS 1645

Query: 295  LKE-------DLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEP 347
            L+         LD  +  +  + +    VE     L   + EL   +   E S+      
Sbjct: 1646 LQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRK----- 1700

Query: 348  VRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQ 407
                    LA    +    R             V+ L  + T+L  Q  + D ++ QL  
Sbjct: 1701 --------LAEQELIETSER-------------VQLLHSQNTSLINQKKKMDADLSQL-- 1737

Query: 408  AKADLEKELECAREGEEERRER---EEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHK 464
             + ++E+ ++  R  EE+ ++      ++ EE++        L+ MKK  ++   ++ H+
Sbjct: 1738 -QTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHR 1796

Query: 465  AQE 467
              E
Sbjct: 1797 LDE 1799



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 29/93 (31%), Positives = 57/93 (61%), Gaps = 9/93 (9%)

Query: 384 LKEERTALQEQL-----LQRDLEVKQ--LLQAKADLEKELECAREGEEERRER-EEVLRE 435
           +KEE T L+E L      +++LE K   LLQ K DL+ +++  ++   +  ER +++++ 
Sbjct: 852 MKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKN 911

Query: 436 EIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
           +IQ L +K++E+ E  ++E+E   E+  K ++L
Sbjct: 912 KIQ-LEAKVKEMNERLEDEEEMNAELTAKKRKL 943



 Score = 37.0 bits (84), Expect = 0.060
 Identities = 76/407 (18%), Positives = 163/407 (40%), Gaps = 64/407 (15%)

Query: 103  RVKRPHLRRSASNGHVP-----GTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRR 157
            R+K+     +A N  +      G+ + ++ +++   I EL++ L  +++     R K+ +
Sbjct: 1079 RLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERT----ARAKVEK 1134

Query: 158  LEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWV---------------------- 195
            L  + SR+  +I + L+ + G   V+    K+ +A +                       
Sbjct: 1135 LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK 1194

Query: 196  ---------------INGLKQRILKLEQQCK-EKDGTISKLQTDMKT-TNLEEMRIAMET 238
                           +  +KQ++ K + + K E D   S ++  +K   NLE+M   +E 
Sbjct: 1195 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED 1254

Query: 239  YYEEVHRL---QTLLASSETTGKKPLGEKKTGA-KRQKKMGSALLS-LSRSVQELTEENQ 293
               E HR    +T  + ++ T ++   + + G   RQ     AL+S L+R     T++ +
Sbjct: 1255 QMNE-HRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLE 1313

Query: 294  SLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLS-----VMESSKSHAAEPV 348
             LK  L+  +     ++            LLR   E E +       V+  + S  A+  
Sbjct: 1314 DLKRQLEEEVKAKNALAHALQSARHDCD-LLREQYEEETEAKAELQRVLSKANSEVAQWR 1372

Query: 349  RSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQA 408
              +    +  +  L    +    +  E    AV  +  + ++L++   +   E++ L+  
Sbjct: 1373 TKYETDAIQRTEELEEAKKKLAQRLQEA-EEAVEAVNAKCSSLEKTKHRLQNEIEDLM-- 1429

Query: 409  KADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEK 455
              D+E+    A   ++++R  +++L E  Q       EL+  +KE +
Sbjct: 1430 -VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEAR 1475


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 96/414 (23%), Positives = 167/414 (40%), Gaps = 65/414 (15%)

Query: 151 MRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQC 210
           +  +L +LEEEN     ++E               AEKR +A W  N        LE Q 
Sbjct: 615 LNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKN------THLEAQL 668

Query: 211 KEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKR 270
           ++ +   ++LQ D++    E+         EE+ +  +     +      L +    AKR
Sbjct: 669 QKAEEAGAELQADLRDIQEEK---------EEIQKKLSESRHQQEAATTQLEQLHQEAKR 719

Query: 271 QKKMGSALLSLSRSVQE---LTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRI 327
           Q+++      L+R+VQE   L  E  +L+  L  V      +++    +  +K  L   +
Sbjct: 720 QEEV------LARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSL 773

Query: 328 VELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLK-- 385
            E +++ SV+E +K      +++   A                    E ++G VR LK  
Sbjct: 774 FEAQQQNSVIEVTKGQLEVQIQTVTQA-------------------KEVIQGEVRCLKLE 814

Query: 386 ---------EERTALQEQLLQRDLEVKQLL-QAKADLEKELECAREG-EEERREREEVLR 434
                    +ER A   QL Q + E K  L Q KA  EKE+   RE  E+ER   ++ L 
Sbjct: 815 LDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELA 874

Query: 435 EEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRP 494
           + +++L  +  EL+   KE++ +   +  + +E      S+  C+     +     L   
Sbjct: 875 KALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESAL-CQMQLETEKERVSLLET 933

Query: 495 RSPCSDGRRDAAARV--LQAQWKVYKHKKKKAV------LDEAAVVLQAAFRGH 540
                    DA+ ++  L+   KV K K+++        L EA   L+ A R H
Sbjct: 934 LLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQH 987



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 82/404 (20%), Positives = 165/404 (40%), Gaps = 66/404 (16%)

Query: 105  KRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSR 164
            K  HL          G  +  +  D+ +E  E++K L   +   +   T+L +L +E  R
Sbjct: 660  KNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKR 719

Query: 165  KDR------QIEQLLDPSRGTDFVRTLAEKRP--DASWVINGL-------KQRILKLEQQ 209
            ++       Q ++ L   +    VR  A +R   D +  + GL       +  + + +QQ
Sbjct: 720  QEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQ 779

Query: 210  CKEKDGTISKLQTDMKT-TNLEE--------MRIAMETYYEEVHRLQTL----LASSETT 256
                + T  +L+  ++T T  +E        +++ ++T   +  + +      LA +E  
Sbjct: 780  NSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQE 839

Query: 257  GKKPLGEKKTGAKR----------------QKKMGSALLSLSRSVQELTEENQSLKEDLD 300
            GK  L ++K   ++                Q+++  AL SL R   EL    +  + +++
Sbjct: 840  GKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEME 899

Query: 301  RVLS------TSPTISKTQGYVEWSKPR--LLRRIVELEKKLSVMESSKSHAAEPVRSHP 352
             + +      T    +  Q  +E  K R  LL  +++ +K+L+          + ++   
Sbjct: 900  AIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQK 959

Query: 353  PACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADL 412
                 ++  L  Q           L+ A R+LKE     ++ L     E   LLQ K DL
Sbjct: 960  LKEQETTGILQTQ-----------LQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDL 1008

Query: 413  EKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKE 456
            +K++E  +     + + + ++ +E+Q    KL+E QE  + +KE
Sbjct: 1009 QKQVEDLKSQLVAQDDSQRLVEQEVQ---EKLRETQEYNRIQKE 1049



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 98/466 (21%), Positives = 196/466 (42%), Gaps = 76/466 (16%)

Query: 125  REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
            ++ + ++ ++ E    L  ++ ++ +++ +L+   E+   K++ ++  LD ++     R 
Sbjct: 1757 QQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQ-----RA 1811

Query: 185  LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVH 244
            LA++  +    +   +Q+    E++ KEK   +         T L+E    ++ + E+  
Sbjct: 1812 LAQRDQELE-ALQQEQQQAQGQEERVKEKADALQGALEQAHMT-LKERHGELQDHKEQAR 1869

Query: 245  RLQTLLASSETTGK---KPLGEKKTGAKRQKKMGSALLSLSRSVQELTEEN--------- 292
            RL+  LA      +   + LG+ +  ++ Q+K   ALL+L +   E  +E+         
Sbjct: 1870 RLEEELAVEGRRVQALEEVLGDLRAESREQEK---ALLALQQQCAEQAQEHEVETRALQD 1926

Query: 293  -----QSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVE-LEKKLSVMESSKSHAAE 346
                 Q++ ++ D+ L      S++  + E +       + E L K  + ++  + H  E
Sbjct: 1927 SWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLE 1986

Query: 347  P-------------VRSHPPACLASSSALHRQPRGDRNK----------DHERLRGAVRD 383
                          +++   AC A S  L    R    +          D ++L+ A+  
Sbjct: 1987 QAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQ 2046

Query: 384  LKEERTALQE--QLLQRDLEVK---QLLQAKADLEKELECAREGEEERREREEVLREEIQ 438
              EE    QE  QLL++ L  +    ++Q K +L +E E     EEE R   + +RE   
Sbjct: 2047 RDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQERE-----EEEIRGLHQSVRELQL 2101

Query: 439  TLTSKLQELQEMKK-EEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSP 497
            TL  K QE+ E+++ +++ +   +PH  +  P         EQ    DS E  L R    
Sbjct: 2102 TLAQKEQEILELRETQQRNNLEALPHSHKTSPME-------EQSLKLDSLEPRLQRELER 2154

Query: 498  CSDGRRDAAARVLQAQWK-------VYKHKKKKAVLDEAAVVLQAA 536
                 R   AR ++ + K       + + K   + L E A+ LQA+
Sbjct: 2155 LQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQAS 2200



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 111/514 (21%), Positives = 213/514 (41%), Gaps = 44/514 (8%)

Query: 117  HVPGTPVYREKE--DMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLD 174
            H+P     RE++     ++I EL+K    Q++   ++  +L  LE+++   + Q  Q+ D
Sbjct: 1491 HLPMAVQEREQKLTVQREQIRELEKDRETQRN---VLEHQLLELEKKDQMIESQRGQVQD 1547

Query: 175  PSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRI 234
              +    +  LA +  +    +   ++ I +LE Q + +   ++ L     T +LEE   
Sbjct: 1548 LKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHL-----TLDLEERSQ 1602

Query: 235  AMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSV-QELTEENQ 293
             ++    ++H L+    S  T   + L E+    K Q++    L      + Q+L   +Q
Sbjct: 1603 ELQAQSSQIHDLE----SHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQ 1658

Query: 294  SLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPP 353
             L    +R+       ++    +E    ++   + E  ++L+         AE  +    
Sbjct: 1659 ELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSK 1718

Query: 354  ACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQL--LQRDLEVKQLLQAKAD 411
            A   S   +    R D+ K+ E  +  + +L+E +  L++QL  L R +    LL ++ +
Sbjct: 1719 AQRGSLEHMKLILR-DKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQRE 1777

Query: 412  -----LEKELECARE-GEEERREREEVLREEIQTLTSKLQELQEMKKEEKE---DCPEVP 462
                 L+++L+ ARE GE + +  +  L E  + L  + QEL+ +++E+++       V 
Sbjct: 1778 QEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVK 1837

Query: 463  HKAQELPAP------TPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKV 516
             KA  L         T   RH E     D  E+          +GRR  A   +    + 
Sbjct: 1838 EKADALQGALEQAHMTLKERHGELQ---DHKEQARRLEEELAVEGRRVQALEEVLGDLRA 1894

Query: 517  YKHKKKKAVLDEAAVVLQAAFRGHLTRTKLLASKAHGSEPPSVPGLPDQSSPVPRVPSPI 576
               +++KA+L   A+  Q A +      +  A +    +  +V    DQ     R     
Sbjct: 1895 ESREQEKALL---ALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALR----- 1946

Query: 577  AQATGSPVQEEAIVIIQSALRAHLARARHSATGK 610
            A++  S  QEEA      AL+  L +A  +  GK
Sbjct: 1947 AESQSSRHQEEAARARAEALQEALGKAHAALQGK 1980



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 72/368 (19%), Positives = 158/368 (42%), Gaps = 40/368 (10%)

Query: 126  EKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTL 185
            E E +  +I EL+K   +QK+ ++L+   L++  +E   +  QI++L       +  R++
Sbjct: 1436 EVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQEL-------EKCRSV 1488

Query: 186  AEKRPDASWVINGLKQRILKLEQQCK--EKDGTISK-------LQTDMKTTNLEEMRIAM 236
             E  P A   +   +Q++    +Q +  EKD    +       L+ + K   +E  R  +
Sbjct: 1489 LEHLPMA---VQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQV 1545

Query: 237  ETYYEEVHRLQTLLASSETTGKKPLGEKK-----TGAKRQKKMGSALLSLSRSVQELTEE 291
            +   +++  L+ L    E    K   ++K      G +  +++  AL  L+  ++E ++E
Sbjct: 1546 QDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRV--ALTHLTLDLEERSQE 1603

Query: 292  NQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSH 351
             Q+    +  + S S  +++     +        +I EL+++   +        + +   
Sbjct: 1604 LQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQ 1663

Query: 352  PPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLE---------- 401
                        RQ +    +D E+++ ++R+   E T  Q QL+Q   E          
Sbjct: 1664 KERIQVLEDQRTRQTK-ILEEDLEQIKLSLRERGRELTT-QRQLMQERAEEGKGPSKAQR 1721

Query: 402  --VKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCP 459
              ++ +     D EKE+EC +E   E +E ++ L +++Q L  K+ E   +  + +++  
Sbjct: 1722 GSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIV 1781

Query: 460  EVPHKAQE 467
             +  + QE
Sbjct: 1782 VLQQQLQE 1789



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 63/338 (18%), Positives = 133/338 (39%), Gaps = 43/338 (12%)

Query: 132  DEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPD 191
            +++   + +L ++  +V+  R + + L+E+   K  Q + L +        +TLAE+  +
Sbjct: 1379 EDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENL--ALLTQTLAEREEE 1436

Query: 192  ASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLA 251
                +  L+ +I +LE+Q + +   +  L  D+K  N E     ++   E++  L+   +
Sbjct: 1437 ----VETLRGQIQELEKQREMQKAALELLSLDLKKRNQE-----VDLQQEQIQELEKCRS 1487

Query: 252  SSE-------------TTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKED 298
              E             T  ++ + E +   + Q+ +    L       ++ E  +   +D
Sbjct: 1488 VLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQD 1547

Query: 299  LDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLAS 358
            L + L T   ++              + I ELE +      + +H    +        A 
Sbjct: 1548 LKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQ 1607

Query: 359  SSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELEC 418
            SS +H                   DL+   T L  +L +RD EVK   +   +L+++ E 
Sbjct: 1608 SSQIH-------------------DLESHSTVLARELQERDQEVKSQREQIEELQRQKEH 1648

Query: 419  AREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKE 456
              +  E R +   + +E IQ L  +     ++ +E+ E
Sbjct: 1649 LTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 83/359 (23%), Positives = 149/359 (41%), Gaps = 61/359 (16%)

Query: 125 REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGT----- 179
           +E  +   E+I+LK    ++K+++    T+L  L  ++ +++   E+++   R T     
Sbjct: 258 KEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILE 317

Query: 180 -----------DFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTN 228
                         R   E++     VI  + Q +++      +  G  + L+ D     
Sbjct: 318 TNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSS--- 374

Query: 229 LEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMG--SALLSLSRSVQ 286
                I  +  Y++  +  TL+ S  T  ++ + +      RQ+  G   A+  L +   
Sbjct: 375 -----IFSQFDYQDADKALTLVRSVLTRRRQAVQD-----LRQQLAGCQEAVNLLQQQHD 424

Query: 287 ELTEENQSLKEDLDRVLSTSPTIS----KTQGYVE-WSKPR--LLRRIVELEKKLSVMES 339
           +  EE ++L++ L ++     T++      QG V+  SK R  L +   EL ++L V+E 
Sbjct: 425 QWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLE- 483

Query: 340 SKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRD 399
               A    R +    L   SA     +G + +  E L  AVR    ER  LQE L+   
Sbjct: 484 --QEAWRLRRVNVELQLQGDSA-----QGQKEEQQEELHLAVR----ERERLQEMLM--G 530

Query: 400 LEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKL----QELQEMKKEE 454
           LE KQ     ++   EL   RE  E      E+LR+E   +T+ L    Q + E+   E
Sbjct: 531 LEAKQ-----SESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSE 584



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 77/370 (20%), Positives = 147/370 (39%), Gaps = 50/370 (13%)

Query: 131 YDEIIELKKSLHVQ--KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEK 188
           ++  +EL  S+  Q    D D   T +R +    +R+ + ++ L     G      L ++
Sbjct: 365 HENSLELDSSIFSQFDYQDADKALTLVRSVL---TRRRQAVQDLRQQLAGCQEAVNLLQQ 421

Query: 189 RPDASWVING--LKQRILKLEQQCKEKDGTISKLQTDMKTTNLE---------EMRIAME 237
           + D  W   G  L+QR+ KL  +     G    LQ ++ + + E         E+R  +E
Sbjct: 422 QHD-QWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLE 480

Query: 238 TYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKE 297
              +E  RL+ +    +  G    G+K+   ++Q+++  A+    R  + L        E
Sbjct: 481 VLEQEAWRLRRVNVELQLQGDSAQGQKE---EQQEELHLAVRERERLQEMLMGLEAKQSE 537

Query: 298 DLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLA 357
            L  +++    +  +                 LE +L   E ++  AA        A L+
Sbjct: 538 SLSELITLREALESSH----------------LEGELLRQEQTEVTAALARAEQSIAELS 581

Query: 358 SSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLL-------QAKA 410
           SS    +    D      +L      L  ++  L +QLLQ + E + +        QA+ 
Sbjct: 582 SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641

Query: 411 DLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPA 470
            L+ +L        E  +R E L E+   L ++LQ+ +E   E + D  ++  + +E+  
Sbjct: 642 ALQVDL-------AEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQK 694

Query: 471 PTPSSRHCEQ 480
               SRH ++
Sbjct: 695 KLSESRHQQE 704



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 66/304 (21%), Positives = 127/304 (41%), Gaps = 44/304 (14%)

Query: 195 VINGLKQRILKLEQQCKEKD-------GTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQ 247
           ++  L+ ++L+    C+E +       G I +   +++  NL+E+ + +E   EE  R +
Sbjct: 55  LVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLE---EEQQRCE 111

Query: 248 TLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSP 307
           +L   +E   +  L  +K     +        +L   V++LT +    +++L R  S   
Sbjct: 112 SL---AEVNTQLRLHMEKADVVNK--------ALREDVEKLTVDWSRARDELMRKESQWQ 160

Query: 308 TISKT-QGYVEWSKPRLL---RRIVELEKKLSVMESSKSH-----AAEPVR---SHPPAC 355
              +  +GY++    RLL   R +V   +    M+S+         AE VR   S    C
Sbjct: 161 MEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCC 220

Query: 356 LASS-SALHRQPRGDRNKDHER------LRGAVRDLKEERTALQEQLLQR----DLEVKQ 404
           L  +  A  R+P G    D         L    ++L++E     ++L+Q     DLE  +
Sbjct: 221 LRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAE 280

Query: 405 LLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHK 464
           L     +L   L  +++  E+  +  + LRE ++ L +   EL E +     +  E    
Sbjct: 281 LQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLS 340

Query: 465 AQEL 468
            Q++
Sbjct: 341 LQQV 344



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 65/369 (17%), Positives = 151/369 (40%), Gaps = 41/369 (11%)

Query: 126  EKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTL 185
            E   +  + ++L+K +   KS +       R +E+E   K R+ ++           + L
Sbjct: 997  ESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEY------NRIQKEL 1050

Query: 186  AEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIA--METYYEEV 243
              ++   +  +   +QR+L L++    +   +S L+ DM+    E+  ++  ME   +EV
Sbjct: 1051 EREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEV 1110

Query: 244  HRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVL 303
               +    + E    + L E +     ++++ ++L +      +L    +S +  L+ + 
Sbjct: 1111 KEKEADFLAQEA---QLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALA 1167

Query: 304  STSPTISKTQGYVEWSK-----PRLLRRIVELEKKLSV----------MESSKSHAAEPV 348
            +     ++ Q   + +       + L  + E   +LS           +E  ++ A    
Sbjct: 1168 AEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLF 1227

Query: 349  RSHPPACLASS----SALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQ 404
            +  P     S+    SALH+      ++D  + +     L+++   L+E+L   + E  Q
Sbjct: 1228 KRGPLLTALSAEAVASALHKL-----HQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQ 1282

Query: 405  LLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQ------EMKKEEKEDC 458
            +     DL+++L   +E + +   ++  L  E+  L   +  LQ      E+++ E +  
Sbjct: 1283 VHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGE 1342

Query: 459  PEVPHKAQE 467
             E+   A+E
Sbjct: 1343 RELLQAAKE 1351



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 25/194 (12%)

Query: 280 SLSRSVQELTEENQSLKEDLDRVL-STSPTISKTQGY---VEWSKPRLLR-RIVELEKKL 334
           SLSR+ QE     Q + +D+ +V+      I++  G+   +E       +    + +K L
Sbjct: 329 SLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKAL 388

Query: 335 SVMES---SKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTAL 391
           +++ S    +  A + +R     C  + + L +Q      ++ + LR  ++ L  ER  L
Sbjct: 389 TLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ-HDQWEEEGKALRQRLQKLTGERDTL 447

Query: 392 QEQLLQRDLEVKQLLQAKAD-LEKELECAREGEEERREREEVLREEIQTLTSKLQELQ-- 448
             Q +         LQ + D L KE E  ++  EE R++ EVL +E   L     ELQ  
Sbjct: 448 AGQTVD--------LQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQ 499

Query: 449 -----EMKKEEKED 457
                  K+E++E+
Sbjct: 500 GDSAQGQKEEQQEE 513


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 78/428 (18%), Positives = 176/428 (41%), Gaps = 52/428 (12%)

Query: 118 VPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR 177
           +P   +  E + +  E+  +   L  Q  + +L     ++ EE+  R++ +I++  +   
Sbjct: 319 LPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEK-- 376

Query: 178 GTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAME 237
               ++   EK  +    I   ++++ + E+   EK+  + + Q +M     E+MR   E
Sbjct: 377 ----IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR-QEEMMWEKEEKMRRQEE 431

Query: 238 TYYEEVHRLQTLLASSETTGKKPLGEKKTGA----KRQKKMGSALLSLSRSVQELTEENQ 293
             +E+  +++ L        K    E+K       + Q+K       + R  +++ E+ +
Sbjct: 432 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 491

Query: 294 SLKEDLDRVLSTSPTISKTQGYVE----------WSKPRLLR----------RIVELEKK 333
            ++E  +++      I + +   E          W +   +R          +I E E+K
Sbjct: 492 KIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEK 551

Query: 334 LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
           +   E       E +             + RQ    R ++ E++R     ++E+    QE
Sbjct: 552 IRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQE-EKIREQEEKIREQEEMTQE 610

Query: 394 QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
           Q  +   + +++ + +  ++++ E  R  EE+ RE+E+ +RE+      K++E +EM +E
Sbjct: 611 QEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQ----EEKIREQEEMMQE 666

Query: 454 EKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQ 513
           ++E   E   K             CEQ+      EE + R      +   +   R+ Q +
Sbjct: 667 QEEKMWEQEEKM------------CEQEEKMQEQEEKMRRQ----EEKMWEQEVRLRQQE 710

Query: 514 WKVYKHKK 521
            K+ +H++
Sbjct: 711 EKMQEHQE 718



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 80/392 (20%), Positives = 153/392 (39%), Gaps = 48/392 (12%)

Query: 137 LKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVI 196
           L++ L  Q   + ++  +   L+         ++QL   +R  D +  L +     SW  
Sbjct: 182 LRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEAR--DLISRLHD-----SWKF 234

Query: 197 NG-LKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMR--IAMETYYEEVHRLQTLLASS 253
            G L+Q +  +  Q K+ D  I +L  +    +LE  R  I  E   E+  +LQ  L   
Sbjct: 235 AGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLV 294

Query: 254 ETTGKKPLGEKKTGAKRQKKMGSALL---SLSRSVQELTEENQSLKEDLDRVLSTSPTIS 310
           E+  K  +       KR+ +    LL    L      L +E QS+   L   +  +   +
Sbjct: 295 ESE-KSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN 353

Query: 311 KTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDR 370
           +     E    R   +I E E+K+   E       E +R                     
Sbjct: 354 RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR--------------------- 392

Query: 371 NKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERRERE 430
            +  E++R      +EE    +E+ ++R  E+  + + +  + ++ E   E EE+ RE E
Sbjct: 393 -EQEEKMRR-----QEEMMWEKEEKMRRQEEM--MWEKEEKMRRQEEMMWEKEEKIRELE 444

Query: 431 EVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEG 490
           E + E+      K++E +E ++EE++   +   + QE        +  EQ+      EE 
Sbjct: 445 EKMHEQ-----EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEK 499

Query: 491 LPRPRSPCSDGRRDAAARVLQAQWKVYKHKKK 522
           + R      +  +       Q Q ++++ ++K
Sbjct: 500 MWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 531


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 96/422 (22%), Positives = 174/422 (41%), Gaps = 79/422 (18%)

Query: 128  EDMYDEIIELKKSL-HVQKSDVDLMRTKLRRLEEENSR---KDRQIEQLLDPSRGTDFVR 183
            E + + I E    L H + +  +LMR   R+ +E       ++   E+L + SR  +   
Sbjct: 1855 EKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRARE--- 1911

Query: 184  TLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDM--KTTNLEEMRIAMETYYE 241
             LA +   A  VI+G        E+Q +EK   I +L+ ++   +  L+E+    +   E
Sbjct: 1912 QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQE 1971

Query: 242  EVHRL---------------QTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQ 286
            E   L               Q LL  +E   K+ L  +    K +  +   + +L   V+
Sbjct: 1972 ERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE 2031

Query: 287  E------------------LTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIV 328
            E                  L ++NQ+L++ L+++       +  +   E  +    + I 
Sbjct: 2032 EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDR---EHERDVFQQEIQ 2088

Query: 329  ELEKKLSVM------ESSKSHAAEPVRSH----PPAC---LASSSALHRQPRGDRNKDHE 375
            +LE++L V+         ++   E + +H       C   L S   L R  + +RN++ E
Sbjct: 2089 KLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQ-ERNEEIE 2147

Query: 376  RLRGAVRDLK-----EERTALQEQLLQRDLEVKQLLQAKADL----EKELECAREGEEER 426
            +L   VR+L+     E+R        + +L ++  LQA+ D     EKE+    E  E+ 
Sbjct: 2148 KLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQF 2207

Query: 427  REREEVLREEIQTL-----------TSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSS 475
            RE  E   EE+Q L           T++LQEL++  K  K+D  ++    +E  A +   
Sbjct: 2208 REELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQD 2267

Query: 476  RH 477
            +H
Sbjct: 2268 QH 2269



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 70/348 (20%), Positives = 149/348 (42%), Gaps = 31/348 (8%)

Query: 135  IELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASW 194
            I LK+    +K   +L+   ++  ++++   + Q+E      R T+    L+ ++   + 
Sbjct: 3098 ITLKREQESEKPSQELLEYNIQ--QKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAE 3155

Query: 195  VINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSE 254
            + + L Q  L+LE   K +   + +L         E  R+ ++   +EVH L   LAS +
Sbjct: 3156 LKSELAQTKLELETTLKAQHKHLKEL---------EAFRLEVKDKTDEVHLLNDTLASEQ 3206

Query: 255  TTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQG 314
               KK    +    K + K+G    S  R  +EL +   SL+    R L  +  + + + 
Sbjct: 3207 ---KKSRELQWALEKEKAKLGR---SEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ 3260

Query: 315  YVEWSKPRLLRRIVELEKKLSV-----MESSKSHAAEPVRSHP-PACLASSSALHRQPRG 368
             +  S+ ++  + +  + +LS      +E      +E VR     + L     LH Q + 
Sbjct: 3261 LLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQS 3320

Query: 369  DRNKDHER--------LRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR 420
                   R        L+   + L+E+ + + E L + +      LQ +  +EK+ +  R
Sbjct: 3321 SDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHR 3380

Query: 421  EGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
            +  +  +E     ++++  L SK+++LQ   +E+++   ++  + Q L
Sbjct: 3381 KTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL 3428



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 67/321 (20%), Positives = 138/321 (42%), Gaps = 61/321 (19%)

Query: 145  KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRIL 204
            K  +  + T+L +LE   S KD ++ Q           + + + +    +    L+++I+
Sbjct: 2483 KGSIINLETRLLQLESTVSAKDLELTQCY---------KQIKDMQEQGQFETEMLQKKIV 2533

Query: 205  KLEQQCKEKDGT--ISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLG 262
             L++  +EK     +S++Q +           A++ Y +     QT+ +  E T  + L 
Sbjct: 2534 NLQKIVEEKVAAALVSQIQLE-----------AVQEYAKFCQDNQTISSEPERTNIQNLN 2582

Query: 263  EKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPR 322
            +      R+ ++GS + +L+  + EL  E+Q ++      + TS  + K Q  VE ++  
Sbjct: 2583 QL-----REDELGSDISALTLRISEL--ESQVVE------MHTSLILEKEQ--VEIAEKN 2627

Query: 323  LLRRIVELEKKLSVMESSKSHAAEPVRSHPPACL----ASSSALHRQPRGDRNKDHERLR 378
            +L +  +L +   ++E ++    E  +   P  +     ++   H         + E LR
Sbjct: 2628 VLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR 2687

Query: 379  GA-------VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREE 431
                     +   KE+   LQE+LL ++  +         L+K+L   R+   E +E+  
Sbjct: 2688 AESVATKAELASYKEKAEKLQEELLVKETNM-------TSLQKDLSQVRDHLAEAKEKLS 2740

Query: 432  VLREEIQTLTSKLQELQEMKK 452
            +L +E +T      E+QE KK
Sbjct: 2741 ILEKEDET------EVQESKK 2755



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 73/368 (19%), Positives = 152/368 (41%), Gaps = 44/368 (11%)

Query: 136  ELKKSLHVQKSDVDLMRTKLRRLEEENS-------RKDRQIEQLLDPSRGTDFVRTLAEK 188
            +L+K +   + DV+   ++   LE+E +       ++++ +E+ L+  R     + L E+
Sbjct: 2018 DLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMR-----KFLDEQ 2072

Query: 189  RPDASWVINGLKQRILKLEQQCK--EKDGTISKLQT----------DMKTTNLEEMRIAM 236
              D     +  +Q I KLEQQ K   +   IS+ QT            KT    E+ ++ 
Sbjct: 2073 AIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSK 2132

Query: 237  ETYY-------EEVHRLQTLLASSETT----GKKPLG--EKKTGAKRQKKMGSALLSLSR 283
            E          EE+ +L+  +   E       +K  G  E K     + ++ +   ++ R
Sbjct: 2133 EQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDR 2192

Query: 284  SVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSH 343
              +E+T   + L++  + + + +  + +    +E  K     R+ ELE++  + +     
Sbjct: 2193 KEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEK 2252

Query: 344  AAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQL-LQRDLEV 402
                ++            L     G   +  +     +  L E+ T LQ+QL +  D +V
Sbjct: 2253 LGLAIKESDAMSTQDQHVLF----GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKV 2308

Query: 403  -KQLLQAKADLEKELECAREGEE-ERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPE 460
             ++  +   DLE ++EC    +E  +R REE + +  + +    QEL  + ++   +   
Sbjct: 2309 IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHS 2368

Query: 461  VPHKAQEL 468
            +  +A  L
Sbjct: 2369 LSEEADSL 2376



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 79/353 (22%), Positives = 154/353 (43%), Gaps = 42/353 (11%)

Query: 125 REKEDMYDEIIEL---KKSLHVQKSDVDLMRTKLRRLEEENSRKD--RQIEQLLDPSRGT 179
           REK++   E +EL    + L +Q   +    T LR     ++  D  +  +Q+L   +  
Sbjct: 219 REKDETMREFLELTEQSQKLQIQFQQLQASET-LRNSTHSSTAADLLQAKQQILTHQQQL 277

Query: 180 DFVRTLAE----KRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIA 235
           +    L E    K+ D +  I+ L+++I   E +  +K    +K +   K T +EE+   
Sbjct: 278 EEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTK 337

Query: 236 METYYEEVHRLQTLLASSETTGKKPLGE-KKTGAKRQKKMGSALLSLSRSVQELTEENQS 294
           +    EE   L+  L    TT  K LGE ++   ++ +++ +  L L+ S Q+  + ++ 
Sbjct: 338 I--IEEEKKTLE--LKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE 393

Query: 295 LKEDLDRVLSTSPTISKTQGY----VEWSKPRLLRRIVELEKKLSVMESSK--SHAAEPV 348
           +K+ +  V        K   +    V+  +    R++ +L  +L  M   +      E +
Sbjct: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI 453

Query: 349 RSHPPACLASSSALHRQPRGDR------------NKDHERLRG-AVRDL--KEERTALQE 393
           R H    +A    +  + +G+             N+D  +L   A+ +L  K + T  Q+
Sbjct: 454 RQH----MAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQK 509

Query: 394 QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQE 446
           + L+ +L +  +L+ K  L+++LE   E     RE+ +  R+ I    SKL E
Sbjct: 510 EKLKEELGL--ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE 560



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 65/343 (18%), Positives = 146/343 (42%), Gaps = 42/343 (12%)

Query: 138 KKSLHVQKSDVDLMRTKLRRLEEE--NSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWV 195
           K +L  +++ + L  +KL+ L++   NS+ +    Q+ +  +  + +R   +++      
Sbjct: 685 KDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE 744

Query: 196 INGLKQRILKLEQQCKEKDGTISKLQTDMKTTN---------LEEMRIAMETYYEEVHRL 246
           +  L+ +   LE+Q KEK+  + +    ++  N         LE+M + + T   +  RL
Sbjct: 745 VQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDM-LKIHTPVSQEERL 803

Query: 247 QTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTS 306
              L S ++  K  + EK+                   ++ L EEN+ LK+   + +  +
Sbjct: 804 -IFLDSIKSKSKDSVWEKE-------------------IEILIEENEDLKQ---QCIQLN 840

Query: 307 PTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQP 366
             I K +    +++        EL+++ + +   K    +          +   AL+ + 
Sbjct: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900

Query: 367 RGDR-NKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEE 425
              R N    +++ +V D  E++T + E L   ++  K       +L ++LE  +  + E
Sbjct: 901 HLQRINPTTVKMKSSVFD--EDKTFVAETLEMGEVVEKD----TTELMEKLEVTKREKLE 954

Query: 426 RREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
             +R   L E+++    ++  L E  K  K++  +V  + +EL
Sbjct: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCREL 997



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 69/350 (19%), Positives = 147/350 (42%), Gaps = 47/350 (13%)

Query: 126  EKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTL 185
            E E+  +E+ +L   L +QK +     T+L+ LE+EN      +E+L    + +D + T 
Sbjct: 2210 ELENKNEEVQQLHMQLEIQKKE---STTRLQELEQENKLFKDDMEKLGLAIKESDAMST- 2265

Query: 186  AEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMK-TTNLEEMRIAMETYYEEVH 244
                 D   +     Q I + E +  + +  ++KLQ  +K TT+ + +    E   +   
Sbjct: 2266 ----QDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLET 2321

Query: 245  RLQTLLASSETTGKKPLGE----KKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLD 300
            +++ L++  E   +    E     +   K Q+++ +     S +   L+EE  SLK  LD
Sbjct: 2322 QIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLD 2381

Query: 301  RVLSTS-------PTISKTQGYVE-------WSKPRLLRRIVEL-------EKKLSVMES 339
             V++          T ++   +++       +   +L + +  L       EK  S+ E+
Sbjct: 2382 VVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPEN 2441

Query: 340  SKSHAAEPVRSHPP---ACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLL 396
            S + A + +    P     L   +    + +       E  +G++ +L+     L+  + 
Sbjct: 2442 SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVS 2501

Query: 397  QRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQE 446
             +DLE+ Q  +   D+          +E+ +   E+L+++I  L   ++E
Sbjct: 2502 AKDLELTQCYKQIKDM----------QEQGQFETEMLQKKIVNLQKIVEE 2541



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 71/307 (23%), Positives = 132/307 (42%), Gaps = 51/307 (16%)

Query: 153 TKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKE 212
           T L  +E E + K  +IE+L          R L E R   ++   GL+Q + + E   K+
Sbjct: 155 THLEMMESELAGKQHEIEELN---------RELEEMR--VTYGTEGLQQ-LQEFEAAIKQ 202

Query: 213 KDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAK--- 269
           +DG I++L     T NL++ R       E+   ++  L  +E + K  +  ++  A    
Sbjct: 203 RDGIITQL-----TANLQQAR------REKDETMREFLELTEQSQKLQIQFQQLQASETL 251

Query: 270 RQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVE 329
           R     S    L ++ Q++    Q L+E  D +L       K    ++ S  +   ++ E
Sbjct: 252 RNSTHSSTAADLLQAKQQILTHQQQLEEQ-DHLLEDYQK-KKEDFTMQISFLQEKIKVYE 309

Query: 330 LEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERT 389
           +E+   V  S+K    E           ++  +  + +    KD  +L  A + L E   
Sbjct: 310 MEQDKKVENSNKEEIQEKETIIEEL---NTKIIEEEKKTLELKD--KLTTADKLLGE--- 361

Query: 390 ALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQE 449
            LQEQ++Q++ E+K +         +LE     ++ER+       EEI+ L   ++ELQ+
Sbjct: 362 -LQEQIVQKNQEIKNM---------KLELTNSKQKERQ-----SSEEIKQLMGTVEELQK 406

Query: 450 MKKEEKE 456
              ++ +
Sbjct: 407 RNHKDSQ 413



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 78/358 (21%), Positives = 143/358 (39%), Gaps = 68/358 (18%)

Query: 126  EKEDMYDEIIELKKSLHVQKSDV-----DLMRTKLRRLEEENSRKDRQIEQL----LDPS 176
            E   M D   EL++ L  +K  V     +L +TKL  LE     + + +++L    L+  
Sbjct: 3131 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLE-LETTLKAQHKHLKELEAFRLEVK 3189

Query: 177  RGTDFVRTLAE-------KRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNL 229
              TD V  L +       K  +  W +   K ++ + E++ KE+               L
Sbjct: 3190 DKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEE---------------L 3234

Query: 230  EEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRS----V 285
            E+++ ++E+  +   +L  LL       K+ L E +   + Q+ +  A LS  +     +
Sbjct: 3235 EDLKFSLESQKQRNLQLNLLLEQQ----KQLLNESQQKIESQRMLYDAQLSEEQGRNLEL 3290

Query: 286  QELTEENQ----SLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRR--IVELEKKLSVMES 339
            Q L E  +     +   LDR       +  + G  + S+P L     + EL+K+L    S
Sbjct: 3291 QVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQ-SRPPLPSEDLLKELQKQLEEKHS 3349

Query: 340  SKSHAAEPVRSHPPACLASSSALHRQPRGDRN--------------KDHERLRGAVRDLK 385
                       +    L +   + +  +  R               K HE L+  V DL+
Sbjct: 3350 RIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHE-LQSKVEDLQ 3408

Query: 386  EERTALQEQLLQRDLEVKQLLQAKADLEK-ELECAREGEEERREREEVLREEIQTLTS 442
             +    ++Q+ + DLE ++L     + +K ELE      EE+RE   +L + +   T+
Sbjct: 3409 RQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELE-----REEKRESRRILYQNLNEPTT 3461



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 76/343 (22%), Positives = 136/343 (39%), Gaps = 58/343 (16%)

Query: 148  VDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLE 207
            V L+    +R++E+       +E L    R     R+L  +       +NG K   LK E
Sbjct: 3050 VGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RSLLSEIQALHAQMNGRKIT-LKRE 3103

Query: 208  QQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTG 267
            Q+ ++    + +     K + + EM++ + +  +    LQ  L+S     K  + E K+ 
Sbjct: 3104 QESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSE----KMVVAELKSE 3159

Query: 268  AKRQK-KMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRR 326
              + K ++ + L +  + ++EL      +K+  D V   + T++  Q      K R L+ 
Sbjct: 3160 LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQ-----KKSRELQW 3214

Query: 327  IVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKE 386
             +E EK                                       +  ER +  + DLK 
Sbjct: 3215 ALEKEK-----------------------------------AKLGRSEERDKEELEDLK- 3238

Query: 387  ERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQE 446
               +L+ Q  QR+L++  LL+ +  L  E +  ++ E +R   +  L EE Q    +LQ 
Sbjct: 3239 --FSLESQK-QRNLQLNLLLEQQKQLLNESQ--QKIESQRMLYDAQLSEE-QGRNLELQV 3292

Query: 447  LQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEE 489
            L E +K    +      + +EL A   SS    Q  PP  SE+
Sbjct: 3293 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSED 3335



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 82/382 (21%), Positives = 164/382 (42%), Gaps = 61/382 (15%)

Query: 124  YREKEDMYDEIIELKKSLHVQKSDVDL-MRTKLRRLEEENSRKDRQIEQLLDPSRGTDFV 182
            Y+E ++ Y  ++++K  L   K+  +L  ++KL+ L EE   +      +   S   D  
Sbjct: 861  YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 920

Query: 183  RTLAEKRPDASWVING------------------LKQRILKLEQQCKEKDGTISKLQTDM 224
            +T   +  +   V+                    L QR+  L +Q K+K G IS L  ++
Sbjct: 921  KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV 980

Query: 225  KTTNLEEMRIAMETYYEEV---HRLQTLLASSETTGKKPL---------GEKKTGAKRQK 272
            K+   E+ ++++     E+   H     + S +T     L         G + + +K  K
Sbjct: 981  KSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNK 1040

Query: 273  KMG---SALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVE 329
              G     ++    S + +T   +S +E L  +L   P+++K +  +  ++P       +
Sbjct: 1041 SFGEESKIMVEDKVSFENMTVGEESKQEQL--ILDHLPSVTK-ESSLRATQP---SENDK 1094

Query: 330  LEKKLSVMESSKSHAAEPVRSHPPACLASSSALH-RQPRGDRNKDHERLRGAVRDLKEER 388
            L+K+L+V++S ++     + +    CL+   + H  Q R     + ++   A+  LKEE 
Sbjct: 1095 LQKELNVLKSEQNDLRLQMEAQ-RICLSLVYSTHVDQVREYMENEKDK---ALCSLKEEL 1150

Query: 389  TALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEER---REREEVLREE----IQTLT 441
               QE+ ++   E++++ Q +    K  E   EG+       + ++ + EE    +QTL 
Sbjct: 1151 IFAQEEKIK---ELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLC 1207

Query: 442  SKLQELQ------EMKKEEKED 457
            S L E        E+  E+KE+
Sbjct: 1208 SVLGEYYTPALKCEVNAEDKEN 1229



 Score = 33.9 bits (76), Expect = 0.51
 Identities = 74/366 (20%), Positives = 154/366 (42%), Gaps = 48/366 (13%)

Query: 128  EDMY--DEIIELKKSLH--VQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVR 183
            E+M+  D+   +++S+H  +  S +D  R  +   E+    +   + Q  +  + T+ +R
Sbjct: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLR 1609

Query: 184  T-----LAEKRPDASWVINGLKQRILKLEQQCKEKDGTISK-LQTDMKTTNLEEMRIAME 237
                  +  +R D       L++ I +L +Q  ++    ++ L ++ +   LEE+    +
Sbjct: 1610 QAHMRQMERQREDQEQ----LQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQ 1665

Query: 238  TYYEEVHRLQTLLASSET---TGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQS 294
                   +L   L +S T    G +  GE +    ++K++      +   +  L+ E  +
Sbjct: 1666 LSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEI--LSNERYA 1723

Query: 295  LKEDLDRVLSTSPTISKTQGYVEWSKPR----LLRRIVELEKKLSVMESSKSHAAEPVRS 350
            L++  +R+L     + KT   VE +  R    +L R  + +   S++  S++ A+     
Sbjct: 1724 LQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCV 1783

Query: 351  HPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQR-------DLEVK 403
            H      +  ++      D  ++   +   V    EE T L ++L++        D E +
Sbjct: 1784 HEEHTRVTDESIPSYSGSDMPRNDINMWSKVT---EEGTELSQRLVRSGFAGTEIDPENE 1840

Query: 404  QLL-----QAKADLEKELECAREG----EEERREREEVLREEI---QTLTSKL---QELQ 448
            +L+     + +A +EK LE   E     E  +  + E++RE     Q  T  L   +EL+
Sbjct: 1841 ELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELR 1900

Query: 449  EMKKEE 454
            E   EE
Sbjct: 1901 ERLHEE 1906


>gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo
           sapiens]
          Length = 1002

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 74/349 (21%), Positives = 148/349 (42%), Gaps = 46/349 (13%)

Query: 136 ELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWV 195
           ++ + +H  + + +   ++++ LE   +    Q+ +   P           + + +A  +
Sbjct: 413 QMSEQVHTLREEKECSMSRVQELETSLAELRNQMAEPPPPEPPAGPSEVEQQLQAEAEHL 472

Query: 196 INGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSE- 254
              L+    +L+ Q ++ +G +S+L  + +   LE  R A E + E+    + +L + + 
Sbjct: 473 RKELEGLAGQLQAQVQDNEG-LSRLNREQEERLLELERAA-ELWGEQAEARRQILETMQN 530

Query: 255 --TTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKT 312
             TT  + L + +   ++  ++ S  + L+    E+T   QS +                
Sbjct: 531 DRTTISRALSQNRELKEQLAELQSGFVKLTNENMEITSALQSEQH--------------- 575

Query: 313 QGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNK 372
                  K  L +++ EL++KLS ++ +               L S  A   Q + D+  
Sbjct: 576 ------VKRELGKKLGELQEKLSELKETVE-------------LKSQEAQSLQQQRDQYL 616

Query: 373 DH-ERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREE 431
            H ++   A + L  E+  L  QLL +   V QL Q +A  +   E AR+  +E +ER E
Sbjct: 617 GHLQQYVAAYQQLTSEKEVLHNQLLLQTQLVDQLQQQEAQGKAVAEMARQELQETQERLE 676

Query: 432 VLREEIQTLTSKLQ------ELQEMKKEEKEDCPEVPHKAQELPAPTPS 474
              ++ Q L ++L       E   + +EE+ED  E   +A  +P P PS
Sbjct: 677 AATQQNQQLRAQLSLMAHPGEGDGLDREEEEDEEEEEEEAVAVPQPMPS 725



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 76/387 (19%), Positives = 141/387 (36%), Gaps = 54/387 (13%)

Query: 126 EKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTL 185
           E E +  E+  L   L  Q  D +     L RL  E      Q E+LL+  R  +     
Sbjct: 468 EAEHLRKELEGLAGQLQAQVQDNE----GLSRLNRE------QEERLLELERAAELWGEQ 517

Query: 186 AEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEE--- 242
           AE R      +   +  I +   Q +E    +++LQ+       E M I      E+   
Sbjct: 518 AEARRQILETMQNDRTTISRALSQNRELKEQLAELQSGFVKLTNENMEITSALQSEQHVK 577

Query: 243 ------VHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLK 296
                 +  LQ  L+  + T +    E ++  +++ +    L     + Q+LT E + L 
Sbjct: 578 RELGKKLGELQEKLSELKETVELKSQEAQSLQQQRDQYLGHLQQYVAAYQQLTSEKEVLH 637

Query: 297 EDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKL--SVMESSKSHAAEPVRSHPPA 354
             L         + + +   +       + + E +++L  +  ++ +  A   + +HP  
Sbjct: 638 NQLLLQTQLVDQLQQQEAQGKAVAEMARQELQETQERLEAATQQNQQLRAQLSLMAHP-- 695

Query: 355 CLASSSALHRQPRGDRNKDHER------------------------LRGAVRDLKEERTA 390
                  L R+   D  ++ E                            AV   +EE+  
Sbjct: 696 --GEGDGLDREEEEDEEEEEEEAVAVPQPMPSIPEDLESREAMVAFFNSAVASAEEEQAR 753

Query: 391 LQEQLLQRDLEVKQLLQAKADLEKELECARE-----GEEERREREEVLREEIQTLTSKLQ 445
           L+ QL ++ +  ++L    A  +KE E A       G+    E    L+  ++ L S+  
Sbjct: 754 LRGQLKEQRVRCRRLAHLLASAQKEPEAAAPAPGTGGDSVCGETHRALQGAMEKLQSRFM 813

Query: 446 ELQEMKKEEKEDCPEVPHKAQELPAPT 472
           EL + K + KE   E+ H+  +L   T
Sbjct: 814 ELMQEKADLKERVEELEHRCIQLSGET 840



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 75/370 (20%), Positives = 135/370 (36%), Gaps = 57/370 (15%)

Query: 175 PSRGTDFVRTLAEKRPDASWVINGLKQR--------ILKLEQQ----------CKEKDGT 216
           PS G       A +  DA  V N + +         + +L QQ          C   +G 
Sbjct: 91  PSPGASLTSMAASQNHDADNVPNLMDETKTFSSTESLRQLSQQLNGLVCESATCVNGEGP 150

Query: 217 ISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLG----EKKTGAKRQK 272
            S        +  +++ +A+++ Y    +L   +   +   ++       EKK   ++Q 
Sbjct: 151 ASSANLKDLESRYQQLAVALDSSYVTNKQLNITIEKLKQQNQEITDQLEEEKKECHQKQG 210

Query: 273 KMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLL---RRIVE 329
            +   L    +++  L  E   L+  L     T     + +G  E    RL    RR+ E
Sbjct: 211 ALREQLQVHIQTIGILVSEKAELQTALAH---TQHAARQKEGESEDLASRLQYSRRRVGE 267

Query: 330 LEKKLSVMESSKSHAAEPVRSHPPACLASSSALHR--QPRGDRNKDHERLRGAVRDLKEE 387
           LE+ LS + + +  A    +       A    L++  Q   D  ++   L   +R L  E
Sbjct: 268 LERALSAVSTQQKKADRYNKELTKERDALRLELYKNTQSNEDLKQEKSELEEKLRVLVTE 327

Query: 388 RTALQEQL--LQRDLEVKQLL-------------------------QAKADLEKELECAR 420
           +  +Q  L  LQ+ LE+ +LL                         Q +A L + +E  R
Sbjct: 328 KAGMQLNLEELQKKLEMTELLLQQFSSRCEAPDANQQLQQAMEERAQLEAHLGQVMESVR 387

Query: 421 EGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQ 480
           + + ER +  E L+ E      ++Q++ E     +E+      + QEL       R+   
Sbjct: 388 QLQMERDKYAENLKGESAMWRQRMQQMSEQVHTLREEKECSMSRVQELETSLAELRNQMA 447

Query: 481 DWPPDSSEEG 490
           + PP     G
Sbjct: 448 EPPPPEPPAG 457



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 66/370 (17%), Positives = 140/370 (37%), Gaps = 36/370 (9%)

Query: 126 EKEDMYDEII-------ELKKSLHVQKSDVDLMRTKLRRLEE-------ENSRKDRQIEQ 171
           EKE ++++++       +L++     K+  ++ R +L+  +E       +N +   Q+  
Sbjct: 632 EKEVLHNQLLLQTQLVDQLQQQEAQGKAVAEMARQELQETQERLEAATQQNQQLRAQLSL 691

Query: 172 LLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEE 231
           +  P  G    R   E   +       + Q +  + +  + ++  ++   + + +   E+
Sbjct: 692 MAHPGEGDGLDREEEEDEEEEEEEAVAVPQPMPSIPEDLESREAMVAFFNSAVASAEEEQ 751

Query: 232 MRIAMETYYEEVH--RLQTLLASSETTGKKPLGEKKTGA-----KRQKKMGSALLSLSRS 284
            R+  +   + V   RL  LLAS++   +       TG      +  + +  A+  L   
Sbjct: 752 ARLRGQLKEQRVRCRRLAHLLASAQKEPEAAAPAPGTGGDSVCGETHRALQGAMEKLQSR 811

Query: 285 VQELTEENQSLKEDLD-------RVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVM 337
             EL +E   LKE ++       ++   + TI +     +  +  L  R  E E+ +S +
Sbjct: 812 FMELMQEKADLKERVEELEHRCIQLSGETDTIGEYIALYQSQRAVLKERHREKEEYISRL 871

Query: 338 ESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQ 397
              K              L     L  +  GDRN+ H R   A ++  +E T+      +
Sbjct: 872 AQDKEEMKVK--------LLELQELVLRLVGDRNEWHGRFLAAAQNPADEPTSGAPAPQE 923

Query: 398 RDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKED 457
                +Q    +  L   +E A+    E   R+    ++I  L  ++Q  +E        
Sbjct: 924 LGAANQQGDLCEVSLAGSVEPAQGEAREGSPRDNPTAQQIMQLLREMQNPRERPGLGSNP 983

Query: 458 CPEVPHKAQE 467
           C    ++A E
Sbjct: 984 CIPFFYRADE 993


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 78/378 (20%), Positives = 172/378 (45%), Gaps = 50/378 (13%)

Query: 110  RRSASNGHVPGTPVYREKEDMYDEIIELKKSLH------------VQKSDV---DLMRTK 154
            + + S G  P T   R+   +  E+ E K SL             +++S++    L  T+
Sbjct: 1981 KETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTR 2040

Query: 155  LRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKD 214
             +R+  +  RK  +  + L   R      +L+++    + ++  L Q++ + E++  +++
Sbjct: 2041 GQRIFVQGQRKLAKASRKLIKKR-----ESLSKEPAKLNKILKAL-QKLTRDERKLTQEE 2094

Query: 215  GTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKM 274
              ++K++   +   ++E R+++E    ++         SE T      ++K  A++Q+K+
Sbjct: 2095 IKMTKMK---RALFVKERRLSIEQSKLDIKEWDFSEKRSELTK-----DEKKLARKQRKL 2146

Query: 275  GSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVE-----------WSKPRL 323
             + +  +    +++TEE   L      V+       + +G +E           W K + 
Sbjct: 2147 ANKMRRMINKEEKMTEEESKLARKHSEVILDD----EEEGGIEEEEVIPFLKRRWRKRKE 2202

Query: 324  LRRIVELEKKLSVMES---SKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGA 380
             +R  + ++K S       S+ H +E + S     L    +L  +   +R ++ ER    
Sbjct: 2203 AKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDE-LEKQESLSSEEEEEREEEEEREEEE 2261

Query: 381  VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVL-REEIQT 439
            VR+ +EER   +E+  ++ +E ++  + K   EK+ E  +E EE   E+EE++  EE ++
Sbjct: 2262 VREEEEERKE-EEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETES 2320

Query: 440  LTSKLQELQEMKKEEKED 457
            L+ + +E +    EE+ D
Sbjct: 2321 LSDEEEEEESCSLEEEVD 2338



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 65/336 (19%), Positives = 138/336 (41%), Gaps = 37/336 (11%)

Query: 132  DEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPD 191
            +E+ + +++L  Q+ ++     +L    EE S K+ ++ Q  +  +  +  + LAE+   
Sbjct: 1698 EELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQ--EEGKLVEEKKKLAEEEEA 1755

Query: 192  ASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIA------METYYEEVHR 245
             +W    L +   KL Q+ +       KL    +    EE R+       +E   +   +
Sbjct: 1756 LAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQK 1815

Query: 246  LQTLLASSETTGKKPL---------GEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLK 296
             +  + S E   K  +          EKK  A+ ++K+     +L  + + LT   + L 
Sbjct: 1816 RERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLV 1875

Query: 297  EDLDRVLSTSPTISKTQGYVEWSKPRLLRR---IVELEKKLSVMESSKSHAAEPVRSHPP 353
            +  +++   +  +++ +  +   K  ++++   + E EKKL  +E S +   E +     
Sbjct: 1876 QVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKM 1935

Query: 354  ACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE 413
                  + +  +         +RLRG +   KEE+          +LE+K+L + K  L 
Sbjct: 1936 KLALEKAMVQGK---------KRLRGELDIAKEEKAL--------NLEMKRLAEEKMRLV 1978

Query: 414  KELECAREGEEERREREEVLREEIQTLTSKLQELQE 449
            +  E   +GE     R+  + +  Q L  +   L+E
Sbjct: 1979 EGKETLSKGETPETSRQRKMTQVEQELFERKLSLEE 2014



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 65/312 (20%), Positives = 125/312 (40%), Gaps = 42/312 (13%)

Query: 158  LEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTI 217
            LEEE SR+  + EQ +     T+  R + E+   A   I+  + R  K   Q + K    
Sbjct: 1546 LEEEVSREGEEKEQQV-----TEEQRHIQEEHKWAR--IHRKRARAEKKRAQEERKLAQE 1598

Query: 218  S-KLQTDMKTTNLEEMRIAMETYYE------EVHRLQTLLASSETT----GKKPLGEKKT 266
              KL  + +    EE ++A + Y +      E+ + +   A  E T    G+K   E + 
Sbjct: 1599 EEKLAQEERQLAQEERKLA-QAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEK 1657

Query: 267  GAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRR 326
             A+++KK+      ++R  ++L ++   L E  + +      + + +  ++W +  L + 
Sbjct: 1658 LAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQE 1717

Query: 327  IVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKE 386
            + ELE  +  +   +                       Q  G   ++ ++L      L  
Sbjct: 1718 LEELEWDMEELSWKEEEL-------------------NQEEGKLVEEKKKLAEEEEALAW 1758

Query: 387  ERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSK--- 443
            +R  L E+  +   E + L+Q K  L +  E   E EE    + E L E+   L  K   
Sbjct: 1759 QREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRER 1818

Query: 444  -LQELQEMKKEE 454
             +  ++E+ K +
Sbjct: 1819 WINSMEELTKNK 1830



 Score = 36.6 bits (83), Expect = 0.078
 Identities = 58/298 (19%), Positives = 123/298 (41%), Gaps = 17/298 (5%)

Query: 204  LKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGE 263
            LK E+  +  +  +S    + +  + EE+     T  EEV R         T  ++ + E
Sbjct: 1516 LKWEEWKQVWENMLSSKSKEQQYKDEEEV-----TLEEEVSREGEEKEQQVTEEQRHIQE 1570

Query: 264  KKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRL 323
            +   A+  +K   A    ++  ++L +E + L ++  ++      ++  Q YV+ ++   
Sbjct: 1571 EHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLA--QAYVKITQDD- 1627

Query: 324  LRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLR--GAV 381
             R + + E K +  E + +   E +             L ++      ++ +  +  G +
Sbjct: 1628 -REMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKL 1686

Query: 382  RDLKEERTALQEQLLQR----DLEVKQLLQAKADLEKELECAREGEEERREREEVLREEI 437
             ++K       E+L QR    D + K+L Q   +LE ++E     EEE  + E  L EE 
Sbjct: 1687 AEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEK 1746

Query: 438  QTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPR 495
            + L  + + L   +++  E+  ++  + + L          ++  P +  EE L R R
Sbjct: 1747 KKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEE--EERLGRKR 1802


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 69/347 (19%), Positives = 147/347 (42%), Gaps = 27/347 (7%)

Query: 125  REKEDMYDEIIELKKSLH---VQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF 181
            R++  + +EI+ LK S       K++++L   ++R   E+  R   Q E  L+ +R    
Sbjct: 1918 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAARQRQL 1975

Query: 182  VRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
                  +R +A   +    Q+ L  E++   +           +   LEE+   ++   E
Sbjct: 1976 AAEEERRRREAEERV----QKSLAAEEEAARQ-----------RKAALEEVE-RLKAKVE 2019

Query: 242  EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDR 301
            E  RL+   A  E+  +  L ++    + Q +  +   ++ +  QEL +  Q  +  LD+
Sbjct: 2020 EARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078

Query: 302  VLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
            +   +    +     E ++ +  R   +  +++   E  K  A E  ++      A + A
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-----AQAQA 2133

Query: 362  LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
               + R +  ++  R   A +    ++ A   ++ +     +Q L+ KA +E+EL   R 
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2193

Query: 422  GEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
              EE   ++ +L EE+Q L ++  E    + + +E+   V  + +EL
Sbjct: 2194 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2240



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 80/384 (20%), Positives = 161/384 (41%), Gaps = 60/384 (15%)

Query: 125  REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
            +EK     E   LK    + +   +L + + RRL+E+   K++  +QL + ++G  F RT
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQG--FQRT 2367

Query: 185  LAEKRPDASWVINGLKQRILKLE---QQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
            L  +R           QR L++    ++ K +   +S+ Q   +  + +  R   E   E
Sbjct: 2368 LEAER-----------QRQLEMSAEAERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGE 2415

Query: 242  EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQ--SLKEDL 299
            ++HR +       T  +    +++      +++  A+  L R  ++L +E +   LK + 
Sbjct: 2416 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2475

Query: 300  DRVLSTSPTISKTQGYVEW---SKPRLLRR--IVELEK-KLSVMESSKSHAAEPVRSHPP 353
             + +     + +TQ   +     K  LL+R   +E EK KL  +   +   A+ +R    
Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-- 2533

Query: 354  ACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE 413
                      ++ +    ++ +RL  ++ + +  +   +E + ++  E++QL        
Sbjct: 2534 ---------QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL-------- 2576

Query: 414  KELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTP 473
                     E++RR++EE+L EE Q L  +LQ L+E  +       EV           P
Sbjct: 2577 ---------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2627

Query: 474  SSRHC----EQDWPPDSSEEGLPR 493
            + R        +  P+ S +GL R
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRR 2651



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 82/370 (22%), Positives = 162/370 (43%), Gaps = 46/370 (12%)

Query: 101  TFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLR---- 156
            +F  K   L RS    HV    +  E E    +  E +++    + +++  + K      
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643

Query: 157  -RLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRIL---KLEQQCKE 212
             RL+ E   + + + Q  +  +  +     A +R  A      ++QR L   +LE+Q + 
Sbjct: 1644 LRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQL 1700

Query: 213  KDGTISK--------LQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEK 264
             +GT  +        ++   +T   E+ R  +E   EE+ RLQ   A++  T K+   E 
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE---EELARLQREAAAA--TQKRQELEA 1755

Query: 265  KTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLL 324
            +  AK + +M   L S +R+ +E    ++  K+ L+        +++     E ++ R L
Sbjct: 1756 EL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRAL 1809

Query: 325  RRIVELEKKLSVMESSKSHA-AEPVRSHPPACLASSSALHRQPR---GDRNKDHERLRGA 380
                + +++L+  ++++  A AE V +   A +  ++ L  +      ++  ++ERLR  
Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869

Query: 381  VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTL 440
              D   +R  L+EQ  Q           KAD+E+ L   R+  +   ER++ L E+  TL
Sbjct: 1870 AEDEAFQRRRLEEQAAQH----------KADIEERLAQLRKASDSELERQKGLVED--TL 1917

Query: 441  TSKLQELQEM 450
              + Q  +E+
Sbjct: 1918 RQRRQVEEEI 1927



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 59/271 (21%), Positives = 107/271 (39%), Gaps = 37/271 (13%)

Query: 199  LKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGK 258
            L  R+    +  +EK   +  L+ +++    E  R   +   E   ++Q  L +++ + +
Sbjct: 1517 LASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575

Query: 259  KPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEW 318
              L  K+               L RS+QE       L+E+ +R         + Q   E 
Sbjct: 1576 AELQSKRAS------FAEKTAQLERSLQEEHVAVAQLREEAER---------RAQQQAEA 1620

Query: 319  SKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLR 378
             + R      E E++L   E  +  A E +R    A   +      Q   ++ K+     
Sbjct: 1621 ERAR-----EEAEREL---ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1672

Query: 379  GAVRDLKEERTALQEQLLQRDLEVKQLL-----QAKADLEKELECAREGEEERREREEVL 433
               R   EE+   Q +L +++LE ++ L     Q +   E+EL   R   E+  ++ ++L
Sbjct: 1673 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1732

Query: 434  REEIQTL-------TSKLQELQ-EMKKEEKE 456
             EE+  L       T K QEL+ E+ K   E
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAE 1763



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 64/353 (18%), Positives = 137/353 (38%), Gaps = 32/353 (9%)

Query: 145  KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRI- 203
            K   +L   + R+L  E  R+ R+ E+ +  S   +     A +R  A   +  LK ++ 
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVERLKAKVE 2019

Query: 204  --LKLEQQCKEKDGTISKLQTD--MKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKK 259
               +L ++ +++     +L  +   K    EE   A     +E   LQ  L   ++   +
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQTLQQEQSVLDQ 2078

Query: 260  PLGEKKTGAKRQKKMGSALLSLSRS-------VQELTEENQSLKEDLDRVLSTSPTISKT 312
              GE +   +  ++   A +   R        V+E     QS +E             K 
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2138

Query: 313  QGYVEWSKPRLLR-RIVELEKKLSV---MESSKSHAAEPVRSHPPACLASSSALHRQPRG 368
            +   E    R  +     L +K +    ME  K  A + +R         ++   +    
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198

Query: 369  DRNK-----DHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE--------KE 415
            D  K     + +RL+    +   +R+ ++E+L    +++++L + KA +E        ++
Sbjct: 2199 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2258

Query: 416  LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
             +  +   +E  E+ + + EE   L+   QE   +++  +ED  +    A+++
Sbjct: 2259 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 60/262 (22%), Positives = 108/262 (41%), Gaps = 33/262 (12%)

Query: 230  EEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQ---------KKMGSALLS 280
            EE R+A +   EE  RL  + A+ E   ++ L E    AK Q         ++M   ++ 
Sbjct: 1346 EEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403

Query: 281  LSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGY----VEWSKPRLLRRIVELEKKLSV 336
               +  +  ++ +S++E+L ++  +S    + +       E S+ R+   I  +  +L  
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1463

Query: 337  MESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLL 396
             E  +  A   ++    A  A +     Q R    ++ ERLR  V+D  + +   + +L 
Sbjct: 1464 TERQRGGAEGELQ----ALRARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELA 1518

Query: 397  QR-------DLEVKQLLQAKADLEKELECA----REGEEERREREEVLREEIQTLTSKLQ 445
             R         E ++ LQA  +L  + E A    R+ E ER  + +V  E  Q   S   
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEA 1576

Query: 446  ELQEMKKEEKEDCPEVPHKAQE 467
            ELQ  +    E   ++    QE
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQE 1598



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 82/418 (19%), Positives = 159/418 (38%), Gaps = 75/418 (17%)

Query: 118  VPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR 177
            + GT    E    ++E ++  +++     +++  +  L++L  +   +    + L D  R
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1154

Query: 178  GTDFV-RTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAM 236
            G   V   L ++  +    +   ++R+ +L ++ +         QTD++   LE++   +
Sbjct: 1155 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV-----LAQTDVRQRELEQLGRQL 1209

Query: 237  ETYYEEVHRLQTLLASS----ETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEEN 292
              Y E    L   L  +    E     PL + +   + Q +   ALL       E  EE 
Sbjct: 1210 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQA-VREQLRQEQALLEEIERHGEKVEEC 1268

Query: 293  Q------------------SLKEDLDRVLST-------SPTISKTQGYVE----WSKPRL 323
            Q                  + K  L+ V S        S + S  Q YV+    +S+   
Sbjct: 1269 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1328

Query: 324  L--RRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAV 381
            L  + I  + + L  ME  +   AE  R+     LA   A   + R       +    A 
Sbjct: 1329 LTSQYIKFISETLRRMEEEE-RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1387

Query: 382  RDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEE----------ERRER-- 429
            R+ KE +  +QE++++R+       Q K  +++EL+  R+  E          E  ER  
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447

Query: 430  ---EEVLRE-----------------EIQTLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
               EE +R                  E+Q L ++ +E +  K++ +E+   +  + Q+
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1505



 Score = 36.6 bits (83), Expect = 0.078
 Identities = 51/260 (19%), Positives = 97/260 (37%), Gaps = 40/260 (15%)

Query: 201  QRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKP 260
            QR  + E Q K         Q +    +L+E  +A+    EE  R     A  +   ++ 
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR----AQQQAEAERA 1623

Query: 261  LGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSK 320
              E +   +R +   +  L L    +E+ ++    + + ++    +   ++ +G  E   
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683

Query: 321  PRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGA 380
             R        +++L+  E  K              LA  +A   Q R    ++  RLR  
Sbjct: 1684 VR--------QRELAEQELEKQRQ-----------LAEGTA---QQRLAAEQELIRLRAE 1721

Query: 381  VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR-----------EGEEERRER 429
                +++R  L+E+L +   E     Q + +LE EL   R             EEE R  
Sbjct: 1722 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1781

Query: 430  EEVLREEIQTLTSKLQELQE 449
             E  ++ ++    + +EL E
Sbjct: 1782 SEKSKQRLEAEAGRFRELAE 1801



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 31/180 (17%), Positives = 73/180 (40%), Gaps = 11/180 (6%)

Query: 281  LSRSVQELTEEN----QSLKEDLDRVLSTSPTISKTQGYVE---WSKPRLLRRIVELEKK 333
            +S +++ + EE     Q   E+ +R+      + K +   E    +K +  R   EL+++
Sbjct: 1337 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1396

Query: 334  LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
            +      +  AA   +    +       L +    +      +   A R     R  ++E
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS----RLRIEE 1452

Query: 394  QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
            ++    L+++   + +   E EL+  R   EE   ++   +EE + L  ++Q+  + K++
Sbjct: 1453 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 69/347 (19%), Positives = 147/347 (42%), Gaps = 27/347 (7%)

Query: 125  REKEDMYDEIIELKKSLH---VQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF 181
            R++  + +EI+ LK S       K++++L   ++R   E+  R   Q E  L+ +R    
Sbjct: 1922 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAARQRQL 1979

Query: 182  VRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
                  +R +A   +    Q+ L  E++   +           +   LEE+   ++   E
Sbjct: 1980 AAEEERRRREAEERV----QKSLAAEEEAARQ-----------RKAALEEVE-RLKAKVE 2023

Query: 242  EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDR 301
            E  RL+   A  E+  +  L ++    + Q +  +   ++ +  QEL +  Q  +  LD+
Sbjct: 2024 EARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2082

Query: 302  VLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
            +   +    +     E ++ +  R   +  +++   E  K  A E  ++      A + A
Sbjct: 2083 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-----AQAQA 2137

Query: 362  LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
               + R +  ++  R   A +    ++ A   ++ +     +Q L+ KA +E+EL   R 
Sbjct: 2138 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2197

Query: 422  GEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
              EE   ++ +L EE+Q L ++  E    + + +E+   V  + +EL
Sbjct: 2198 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2244



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 80/384 (20%), Positives = 161/384 (41%), Gaps = 60/384 (15%)

Query: 125  REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
            +EK     E   LK    + +   +L + + RRL+E+   K++  +QL + ++G  F RT
Sbjct: 2317 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQG--FQRT 2371

Query: 185  LAEKRPDASWVINGLKQRILKLE---QQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
            L  +R           QR L++    ++ K +   +S+ Q   +  + +  R   E   E
Sbjct: 2372 LEAER-----------QRQLEMSAEAERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGE 2419

Query: 242  EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQ--SLKEDL 299
            ++HR +       T  +    +++      +++  A+  L R  ++L +E +   LK + 
Sbjct: 2420 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2479

Query: 300  DRVLSTSPTISKTQGYVEW---SKPRLLRR--IVELEK-KLSVMESSKSHAAEPVRSHPP 353
             + +     + +TQ   +     K  LL+R   +E EK KL  +   +   A+ +R    
Sbjct: 2480 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-- 2537

Query: 354  ACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE 413
                      ++ +    ++ +RL  ++ + +  +   +E + ++  E++QL        
Sbjct: 2538 ---------QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL-------- 2580

Query: 414  KELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTP 473
                     E++RR++EE+L EE Q L  +LQ L+E  +       EV           P
Sbjct: 2581 ---------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2631

Query: 474  SSRHC----EQDWPPDSSEEGLPR 493
            + R        +  P+ S +GL R
Sbjct: 2632 NGRDALDGPAAEAEPEHSFDGLRR 2655



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 82/370 (22%), Positives = 162/370 (43%), Gaps = 46/370 (12%)

Query: 101  TFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLR---- 156
            +F  K   L RS    HV    +  E E    +  E +++    + +++  + K      
Sbjct: 1588 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1647

Query: 157  -RLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRIL---KLEQQCKE 212
             RL+ E   + + + Q  +  +  +     A +R  A      ++QR L   +LE+Q + 
Sbjct: 1648 LRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQL 1704

Query: 213  KDGTISK--------LQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEK 264
             +GT  +        ++   +T   E+ R  +E   EE+ RLQ   A++  T K+   E 
Sbjct: 1705 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE---EELARLQREAAAA--TQKRQELEA 1759

Query: 265  KTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLL 324
            +  AK + +M   L S +R+ +E    ++  K+ L+        +++     E ++ R L
Sbjct: 1760 EL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRAL 1813

Query: 325  RRIVELEKKLSVMESSKSHA-AEPVRSHPPACLASSSALHRQPR---GDRNKDHERLRGA 380
                + +++L+  ++++  A AE V +   A +  ++ L  +      ++  ++ERLR  
Sbjct: 1814 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1873

Query: 381  VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTL 440
              D   +R  L+EQ  Q           KAD+E+ L   R+  +   ER++ L E+  TL
Sbjct: 1874 AEDEAFQRRRLEEQAAQH----------KADIEERLAQLRKASDSELERQKGLVED--TL 1921

Query: 441  TSKLQELQEM 450
              + Q  +E+
Sbjct: 1922 RQRRQVEEEI 1931



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 59/271 (21%), Positives = 107/271 (39%), Gaps = 37/271 (13%)

Query: 199  LKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGK 258
            L  R+    +  +EK   +  L+ +++    E  R   +   E   ++Q  L +++ + +
Sbjct: 1521 LASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579

Query: 259  KPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEW 318
              L  K+               L RS+QE       L+E+ +R         + Q   E 
Sbjct: 1580 AELQSKRAS------FAEKTAQLERSLQEEHVAVAQLREEAER---------RAQQQAEA 1624

Query: 319  SKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLR 378
             + R      E E++L   E  +  A E +R    A   +      Q   ++ K+     
Sbjct: 1625 ERAR-----EEAEREL---ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1676

Query: 379  GAVRDLKEERTALQEQLLQRDLEVKQLL-----QAKADLEKELECAREGEEERREREEVL 433
               R   EE+   Q +L +++LE ++ L     Q +   E+EL   R   E+  ++ ++L
Sbjct: 1677 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1736

Query: 434  REEIQTL-------TSKLQELQ-EMKKEEKE 456
             EE+  L       T K QEL+ E+ K   E
Sbjct: 1737 EEELARLQREAAAATQKRQELEAELAKVRAE 1767



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 64/353 (18%), Positives = 137/353 (38%), Gaps = 32/353 (9%)

Query: 145  KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRI- 203
            K   +L   + R+L  E  R+ R+ E+ +  S   +     A +R  A   +  LK ++ 
Sbjct: 1966 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVERLKAKVE 2023

Query: 204  --LKLEQQCKEKDGTISKLQTD--MKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKK 259
               +L ++ +++     +L  +   K    EE   A     +E   LQ  L   ++   +
Sbjct: 2024 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQTLQQEQSVLDQ 2082

Query: 260  PLGEKKTGAKRQKKMGSALLSLSRS-------VQELTEENQSLKEDLDRVLSTSPTISKT 312
              GE +   +  ++   A +   R        V+E     QS +E             K 
Sbjct: 2083 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2142

Query: 313  QGYVEWSKPRLLR-RIVELEKKLSV---MESSKSHAAEPVRSHPPACLASSSALHRQPRG 368
            +   E    R  +     L +K +    ME  K  A + +R         ++   +    
Sbjct: 2143 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2202

Query: 369  DRNK-----DHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE--------KE 415
            D  K     + +RL+    +   +R+ ++E+L    +++++L + KA +E        ++
Sbjct: 2203 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2262

Query: 416  LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
             +  +   +E  E+ + + EE   L+   QE   +++  +ED  +    A+++
Sbjct: 2263 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2315



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 60/262 (22%), Positives = 108/262 (41%), Gaps = 33/262 (12%)

Query: 230  EEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQ---------KKMGSALLS 280
            EE R+A +   EE  RL  + A+ E   ++ L E    AK Q         ++M   ++ 
Sbjct: 1350 EEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1407

Query: 281  LSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGY----VEWSKPRLLRRIVELEKKLSV 336
               +  +  ++ +S++E+L ++  +S    + +       E S+ R+   I  +  +L  
Sbjct: 1408 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1467

Query: 337  MESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLL 396
             E  +  A   ++    A  A +     Q R    ++ ERLR  V+D  + +   + +L 
Sbjct: 1468 TERQRGGAEGELQ----ALRARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELA 1522

Query: 397  QR-------DLEVKQLLQAKADLEKELECA----REGEEERREREEVLREEIQTLTSKLQ 445
             R         E ++ LQA  +L  + E A    R+ E ER  + +V  E  Q   S   
Sbjct: 1523 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEA 1580

Query: 446  ELQEMKKEEKEDCPEVPHKAQE 467
            ELQ  +    E   ++    QE
Sbjct: 1581 ELQSKRASFAEKTAQLERSLQE 1602



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 82/418 (19%), Positives = 159/418 (38%), Gaps = 75/418 (17%)

Query: 118  VPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR 177
            + GT    E    ++E ++  +++     +++  +  L++L  +   +    + L D  R
Sbjct: 1099 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1158

Query: 178  GTDFV-RTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAM 236
            G   V   L ++  +    +   ++R+ +L ++ +         QTD++   LE++   +
Sbjct: 1159 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV-----LAQTDVRQRELEQLGRQL 1213

Query: 237  ETYYEEVHRLQTLLASS----ETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEEN 292
              Y E    L   L  +    E     PL + +   + Q +   ALL       E  EE 
Sbjct: 1214 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQA-VREQLRQEQALLEEIERHGEKVEEC 1272

Query: 293  Q------------------SLKEDLDRVLST-------SPTISKTQGYVE----WSKPRL 323
            Q                  + K  L+ V S        S + S  Q YV+    +S+   
Sbjct: 1273 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1332

Query: 324  L--RRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAV 381
            L  + I  + + L  ME  +   AE  R+     LA   A   + R       +    A 
Sbjct: 1333 LTSQYIKFISETLRRMEEEE-RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1391

Query: 382  RDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEE----------ERRER-- 429
            R+ KE +  +QE++++R+       Q K  +++EL+  R+  E          E  ER  
Sbjct: 1392 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1451

Query: 430  ---EEVLRE-----------------EIQTLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
               EE +R                  E+Q L ++ +E +  K++ +E+   +  + Q+
Sbjct: 1452 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1509



 Score = 36.6 bits (83), Expect = 0.078
 Identities = 51/260 (19%), Positives = 97/260 (37%), Gaps = 40/260 (15%)

Query: 201  QRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKP 260
            QR  + E Q K         Q +    +L+E  +A+    EE  R     A  +   ++ 
Sbjct: 1575 QRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR----AQQQAEAERA 1627

Query: 261  LGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSK 320
              E +   +R +   +  L L    +E+ ++    + + ++    +   ++ +G  E   
Sbjct: 1628 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1687

Query: 321  PRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGA 380
             R        +++L+  E  K              LA  +A   Q R    ++  RLR  
Sbjct: 1688 VR--------QRELAEQELEKQRQ-----------LAEGTA---QQRLAAEQELIRLRAE 1725

Query: 381  VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR-----------EGEEERRER 429
                +++R  L+E+L +   E     Q + +LE EL   R             EEE R  
Sbjct: 1726 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1785

Query: 430  EEVLREEIQTLTSKLQELQE 449
             E  ++ ++    + +EL E
Sbjct: 1786 SEKSKQRLEAEAGRFRELAE 1805



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 31/180 (17%), Positives = 73/180 (40%), Gaps = 11/180 (6%)

Query: 281  LSRSVQELTEEN----QSLKEDLDRVLSTSPTISKTQGYVE---WSKPRLLRRIVELEKK 333
            +S +++ + EE     Q   E+ +R+      + K +   E    +K +  R   EL+++
Sbjct: 1341 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1400

Query: 334  LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
            +      +  AA   +    +       L +    +      +   A R     R  ++E
Sbjct: 1401 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS----RLRIEE 1456

Query: 394  QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
            ++    L+++   + +   E EL+  R   EE   ++   +EE + L  ++Q+  + K++
Sbjct: 1457 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1516


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 69/347 (19%), Positives = 147/347 (42%), Gaps = 27/347 (7%)

Query: 125  REKEDMYDEIIELKKSLH---VQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF 181
            R++  + +EI+ LK S       K++++L   ++R   E+  R   Q E  L+ +R    
Sbjct: 1918 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAARQRQL 1975

Query: 182  VRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
                  +R +A   +    Q+ L  E++   +           +   LEE+   ++   E
Sbjct: 1976 AAEEERRRREAEERV----QKSLAAEEEAARQ-----------RKAALEEVE-RLKAKVE 2019

Query: 242  EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDR 301
            E  RL+   A  E+  +  L ++    + Q +  +   ++ +  QEL +  Q  +  LD+
Sbjct: 2020 EARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078

Query: 302  VLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
            +   +    +     E ++ +  R   +  +++   E  K  A E  ++      A + A
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-----AQAQA 2133

Query: 362  LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
               + R +  ++  R   A +    ++ A   ++ +     +Q L+ KA +E+EL   R 
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2193

Query: 422  GEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
              EE   ++ +L EE+Q L ++  E    + + +E+   V  + +EL
Sbjct: 2194 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2240



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 80/384 (20%), Positives = 161/384 (41%), Gaps = 60/384 (15%)

Query: 125  REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
            +EK     E   LK    + +   +L + + RRL+E+   K++  +QL + ++G  F RT
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQG--FQRT 2367

Query: 185  LAEKRPDASWVINGLKQRILKLE---QQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
            L  +R           QR L++    ++ K +   +S+ Q   +  + +  R   E   E
Sbjct: 2368 LEAER-----------QRQLEMSAEAERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGE 2415

Query: 242  EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQ--SLKEDL 299
            ++HR +       T  +    +++      +++  A+  L R  ++L +E +   LK + 
Sbjct: 2416 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2475

Query: 300  DRVLSTSPTISKTQGYVEW---SKPRLLRR--IVELEK-KLSVMESSKSHAAEPVRSHPP 353
             + +     + +TQ   +     K  LL+R   +E EK KL  +   +   A+ +R    
Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-- 2533

Query: 354  ACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE 413
                      ++ +    ++ +RL  ++ + +  +   +E + ++  E++QL        
Sbjct: 2534 ---------QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL-------- 2576

Query: 414  KELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTP 473
                     E++RR++EE+L EE Q L  +LQ L+E  +       EV           P
Sbjct: 2577 ---------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2627

Query: 474  SSRHC----EQDWPPDSSEEGLPR 493
            + R        +  P+ S +GL R
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRR 2651



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 82/370 (22%), Positives = 162/370 (43%), Gaps = 46/370 (12%)

Query: 101  TFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLR---- 156
            +F  K   L RS    HV    +  E E    +  E +++    + +++  + K      
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643

Query: 157  -RLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRIL---KLEQQCKE 212
             RL+ E   + + + Q  +  +  +     A +R  A      ++QR L   +LE+Q + 
Sbjct: 1644 LRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQL 1700

Query: 213  KDGTISK--------LQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEK 264
             +GT  +        ++   +T   E+ R  +E   EE+ RLQ   A++  T K+   E 
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE---EELARLQREAAAA--TQKRQELEA 1755

Query: 265  KTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLL 324
            +  AK + +M   L S +R+ +E    ++  K+ L+        +++     E ++ R L
Sbjct: 1756 EL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRAL 1809

Query: 325  RRIVELEKKLSVMESSKSHA-AEPVRSHPPACLASSSALHRQPR---GDRNKDHERLRGA 380
                + +++L+  ++++  A AE V +   A +  ++ L  +      ++  ++ERLR  
Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869

Query: 381  VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTL 440
              D   +R  L+EQ  Q           KAD+E+ L   R+  +   ER++ L E+  TL
Sbjct: 1870 AEDEAFQRRRLEEQAAQH----------KADIEERLAQLRKASDSELERQKGLVED--TL 1917

Query: 441  TSKLQELQEM 450
              + Q  +E+
Sbjct: 1918 RQRRQVEEEI 1927



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 59/271 (21%), Positives = 107/271 (39%), Gaps = 37/271 (13%)

Query: 199  LKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGK 258
            L  R+    +  +EK   +  L+ +++    E  R   +   E   ++Q  L +++ + +
Sbjct: 1517 LASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575

Query: 259  KPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEW 318
              L  K+               L RS+QE       L+E+ +R         + Q   E 
Sbjct: 1576 AELQSKRAS------FAEKTAQLERSLQEEHVAVAQLREEAER---------RAQQQAEA 1620

Query: 319  SKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLR 378
             + R      E E++L   E  +  A E +R    A   +      Q   ++ K+     
Sbjct: 1621 ERAR-----EEAEREL---ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1672

Query: 379  GAVRDLKEERTALQEQLLQRDLEVKQLL-----QAKADLEKELECAREGEEERREREEVL 433
               R   EE+   Q +L +++LE ++ L     Q +   E+EL   R   E+  ++ ++L
Sbjct: 1673 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1732

Query: 434  REEIQTL-------TSKLQELQ-EMKKEEKE 456
             EE+  L       T K QEL+ E+ K   E
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAE 1763



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 64/353 (18%), Positives = 137/353 (38%), Gaps = 32/353 (9%)

Query: 145  KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRI- 203
            K   +L   + R+L  E  R+ R+ E+ +  S   +     A +R  A   +  LK ++ 
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVERLKAKVE 2019

Query: 204  --LKLEQQCKEKDGTISKLQTD--MKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKK 259
               +L ++ +++     +L  +   K    EE   A     +E   LQ  L   ++   +
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQTLQQEQSVLDQ 2078

Query: 260  PLGEKKTGAKRQKKMGSALLSLSRS-------VQELTEENQSLKEDLDRVLSTSPTISKT 312
              GE +   +  ++   A +   R        V+E     QS +E             K 
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2138

Query: 313  QGYVEWSKPRLLR-RIVELEKKLSV---MESSKSHAAEPVRSHPPACLASSSALHRQPRG 368
            +   E    R  +     L +K +    ME  K  A + +R         ++   +    
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198

Query: 369  DRNK-----DHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE--------KE 415
            D  K     + +RL+    +   +R+ ++E+L    +++++L + KA +E        ++
Sbjct: 2199 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2258

Query: 416  LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
             +  +   +E  E+ + + EE   L+   QE   +++  +ED  +    A+++
Sbjct: 2259 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 60/262 (22%), Positives = 108/262 (41%), Gaps = 33/262 (12%)

Query: 230  EEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQ---------KKMGSALLS 280
            EE R+A +   EE  RL  + A+ E   ++ L E    AK Q         ++M   ++ 
Sbjct: 1346 EEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403

Query: 281  LSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGY----VEWSKPRLLRRIVELEKKLSV 336
               +  +  ++ +S++E+L ++  +S    + +       E S+ R+   I  +  +L  
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1463

Query: 337  MESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLL 396
             E  +  A   ++    A  A +     Q R    ++ ERLR  V+D  + +   + +L 
Sbjct: 1464 TERQRGGAEGELQ----ALRARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELA 1518

Query: 397  QR-------DLEVKQLLQAKADLEKELECA----REGEEERREREEVLREEIQTLTSKLQ 445
             R         E ++ LQA  +L  + E A    R+ E ER  + +V  E  Q   S   
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEA 1576

Query: 446  ELQEMKKEEKEDCPEVPHKAQE 467
            ELQ  +    E   ++    QE
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQE 1598



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 82/418 (19%), Positives = 159/418 (38%), Gaps = 75/418 (17%)

Query: 118  VPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR 177
            + GT    E    ++E ++  +++     +++  +  L++L  +   +    + L D  R
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1154

Query: 178  GTDFV-RTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAM 236
            G   V   L ++  +    +   ++R+ +L ++ +         QTD++   LE++   +
Sbjct: 1155 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV-----LAQTDVRQRELEQLGRQL 1209

Query: 237  ETYYEEVHRLQTLLASS----ETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEEN 292
              Y E    L   L  +    E     PL + +   + Q +   ALL       E  EE 
Sbjct: 1210 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQA-VREQLRQEQALLEEIERHGEKVEEC 1268

Query: 293  Q------------------SLKEDLDRVLST-------SPTISKTQGYVE----WSKPRL 323
            Q                  + K  L+ V S        S + S  Q YV+    +S+   
Sbjct: 1269 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1328

Query: 324  L--RRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAV 381
            L  + I  + + L  ME  +   AE  R+     LA   A   + R       +    A 
Sbjct: 1329 LTSQYIKFISETLRRMEEEE-RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1387

Query: 382  RDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEE----------ERRER-- 429
            R+ KE +  +QE++++R+       Q K  +++EL+  R+  E          E  ER  
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447

Query: 430  ---EEVLRE-----------------EIQTLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
               EE +R                  E+Q L ++ +E +  K++ +E+   +  + Q+
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1505



 Score = 36.6 bits (83), Expect = 0.078
 Identities = 51/260 (19%), Positives = 97/260 (37%), Gaps = 40/260 (15%)

Query: 201  QRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKP 260
            QR  + E Q K         Q +    +L+E  +A+    EE  R     A  +   ++ 
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR----AQQQAEAERA 1623

Query: 261  LGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSK 320
              E +   +R +   +  L L    +E+ ++    + + ++    +   ++ +G  E   
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683

Query: 321  PRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGA 380
             R        +++L+  E  K              LA  +A   Q R    ++  RLR  
Sbjct: 1684 VR--------QRELAEQELEKQRQ-----------LAEGTA---QQRLAAEQELIRLRAE 1721

Query: 381  VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR-----------EGEEERRER 429
                +++R  L+E+L +   E     Q + +LE EL   R             EEE R  
Sbjct: 1722 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1781

Query: 430  EEVLREEIQTLTSKLQELQE 449
             E  ++ ++    + +EL E
Sbjct: 1782 SEKSKQRLEAEAGRFRELAE 1801



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 31/180 (17%), Positives = 73/180 (40%), Gaps = 11/180 (6%)

Query: 281  LSRSVQELTEEN----QSLKEDLDRVLSTSPTISKTQGYVE---WSKPRLLRRIVELEKK 333
            +S +++ + EE     Q   E+ +R+      + K +   E    +K +  R   EL+++
Sbjct: 1337 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1396

Query: 334  LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
            +      +  AA   +    +       L +    +      +   A R     R  ++E
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS----RLRIEE 1452

Query: 394  QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
            ++    L+++   + +   E EL+  R   EE   ++   +EE + L  ++Q+  + K++
Sbjct: 1453 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 69/347 (19%), Positives = 147/347 (42%), Gaps = 27/347 (7%)

Query: 125  REKEDMYDEIIELKKSLH---VQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF 181
            R++  + +EI+ LK S       K++++L   ++R   E+  R   Q E  L+ +R    
Sbjct: 1886 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAARQRQL 1943

Query: 182  VRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
                  +R +A   +    Q+ L  E++   +           +   LEE+   ++   E
Sbjct: 1944 AAEEERRRREAEERV----QKSLAAEEEAARQ-----------RKAALEEVE-RLKAKVE 1987

Query: 242  EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDR 301
            E  RL+   A  E+  +  L ++    + Q +  +   ++ +  QEL +  Q  +  LD+
Sbjct: 1988 EARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2046

Query: 302  VLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
            +   +    +     E ++ +  R   +  +++   E  K  A E  ++      A + A
Sbjct: 2047 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-----AQAQA 2101

Query: 362  LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
               + R +  ++  R   A +    ++ A   ++ +     +Q L+ KA +E+EL   R 
Sbjct: 2102 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2161

Query: 422  GEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
              EE   ++ +L EE+Q L ++  E    + + +E+   V  + +EL
Sbjct: 2162 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2208



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 80/384 (20%), Positives = 161/384 (41%), Gaps = 60/384 (15%)

Query: 125  REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
            +EK     E   LK    + +   +L + + RRL+E+   K++  +QL + ++G  F RT
Sbjct: 2281 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQG--FQRT 2335

Query: 185  LAEKRPDASWVINGLKQRILKLE---QQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
            L  +R           QR L++    ++ K +   +S+ Q   +  + +  R   E   E
Sbjct: 2336 LEAER-----------QRQLEMSAEAERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGE 2383

Query: 242  EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQ--SLKEDL 299
            ++HR +       T  +    +++      +++  A+  L R  ++L +E +   LK + 
Sbjct: 2384 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2443

Query: 300  DRVLSTSPTISKTQGYVEW---SKPRLLRR--IVELEK-KLSVMESSKSHAAEPVRSHPP 353
             + +     + +TQ   +     K  LL+R   +E EK KL  +   +   A+ +R    
Sbjct: 2444 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-- 2501

Query: 354  ACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE 413
                      ++ +    ++ +RL  ++ + +  +   +E + ++  E++QL        
Sbjct: 2502 ---------QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL-------- 2544

Query: 414  KELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTP 473
                     E++RR++EE+L EE Q L  +LQ L+E  +       EV           P
Sbjct: 2545 ---------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2595

Query: 474  SSRHC----EQDWPPDSSEEGLPR 493
            + R        +  P+ S +GL R
Sbjct: 2596 NGRDALDGPAAEAEPEHSFDGLRR 2619



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 82/370 (22%), Positives = 162/370 (43%), Gaps = 46/370 (12%)

Query: 101  TFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLR---- 156
            +F  K   L RS    HV    +  E E    +  E +++    + +++  + K      
Sbjct: 1552 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1611

Query: 157  -RLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRIL---KLEQQCKE 212
             RL+ E   + + + Q  +  +  +     A +R  A      ++QR L   +LE+Q + 
Sbjct: 1612 LRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQL 1668

Query: 213  KDGTISK--------LQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEK 264
             +GT  +        ++   +T   E+ R  +E   EE+ RLQ   A++  T K+   E 
Sbjct: 1669 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE---EELARLQREAAAA--TQKRQELEA 1723

Query: 265  KTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLL 324
            +  AK + +M   L S +R+ +E    ++  K+ L+        +++     E ++ R L
Sbjct: 1724 EL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRAL 1777

Query: 325  RRIVELEKKLSVMESSKSHA-AEPVRSHPPACLASSSALHRQPR---GDRNKDHERLRGA 380
                + +++L+  ++++  A AE V +   A +  ++ L  +      ++  ++ERLR  
Sbjct: 1778 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1837

Query: 381  VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTL 440
              D   +R  L+EQ  Q           KAD+E+ L   R+  +   ER++ L E+  TL
Sbjct: 1838 AEDEAFQRRRLEEQAAQH----------KADIEERLAQLRKASDSELERQKGLVED--TL 1885

Query: 441  TSKLQELQEM 450
              + Q  +E+
Sbjct: 1886 RQRRQVEEEI 1895



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 59/271 (21%), Positives = 107/271 (39%), Gaps = 37/271 (13%)

Query: 199  LKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGK 258
            L  R+    +  +EK   +  L+ +++    E  R   +   E   ++Q  L +++ + +
Sbjct: 1485 LASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543

Query: 259  KPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEW 318
              L  K+               L RS+QE       L+E+ +R         + Q   E 
Sbjct: 1544 AELQSKRAS------FAEKTAQLERSLQEEHVAVAQLREEAER---------RAQQQAEA 1588

Query: 319  SKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLR 378
             + R      E E++L   E  +  A E +R    A   +      Q   ++ K+     
Sbjct: 1589 ERAR-----EEAEREL---ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1640

Query: 379  GAVRDLKEERTALQEQLLQRDLEVKQLL-----QAKADLEKELECAREGEEERREREEVL 433
               R   EE+   Q +L +++LE ++ L     Q +   E+EL   R   E+  ++ ++L
Sbjct: 1641 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1700

Query: 434  REEIQTL-------TSKLQELQ-EMKKEEKE 456
             EE+  L       T K QEL+ E+ K   E
Sbjct: 1701 EEELARLQREAAAATQKRQELEAELAKVRAE 1731



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 64/353 (18%), Positives = 137/353 (38%), Gaps = 32/353 (9%)

Query: 145  KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRI- 203
            K   +L   + R+L  E  R+ R+ E+ +  S   +     A +R  A   +  LK ++ 
Sbjct: 1930 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVERLKAKVE 1987

Query: 204  --LKLEQQCKEKDGTISKLQTD--MKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKK 259
               +L ++ +++     +L  +   K    EE   A     +E   LQ  L   ++   +
Sbjct: 1988 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQTLQQEQSVLDQ 2046

Query: 260  PLGEKKTGAKRQKKMGSALLSLSRS-------VQELTEENQSLKEDLDRVLSTSPTISKT 312
              GE +   +  ++   A +   R        V+E     QS +E             K 
Sbjct: 2047 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2106

Query: 313  QGYVEWSKPRLLR-RIVELEKKLSV---MESSKSHAAEPVRSHPPACLASSSALHRQPRG 368
            +   E    R  +     L +K +    ME  K  A + +R         ++   +    
Sbjct: 2107 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2166

Query: 369  DRNK-----DHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE--------KE 415
            D  K     + +RL+    +   +R+ ++E+L    +++++L + KA +E        ++
Sbjct: 2167 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2226

Query: 416  LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
             +  +   +E  E+ + + EE   L+   QE   +++  +ED  +    A+++
Sbjct: 2227 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2279



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 60/262 (22%), Positives = 108/262 (41%), Gaps = 33/262 (12%)

Query: 230  EEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQ---------KKMGSALLS 280
            EE R+A +   EE  RL  + A+ E   ++ L E    AK Q         ++M   ++ 
Sbjct: 1314 EEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1371

Query: 281  LSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGY----VEWSKPRLLRRIVELEKKLSV 336
               +  +  ++ +S++E+L ++  +S    + +       E S+ R+   I  +  +L  
Sbjct: 1372 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1431

Query: 337  MESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLL 396
             E  +  A   ++    A  A +     Q R    ++ ERLR  V+D  + +   + +L 
Sbjct: 1432 TERQRGGAEGELQ----ALRARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELA 1486

Query: 397  QR-------DLEVKQLLQAKADLEKELECA----REGEEERREREEVLREEIQTLTSKLQ 445
             R         E ++ LQA  +L  + E A    R+ E ER  + +V  E  Q   S   
Sbjct: 1487 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEA 1544

Query: 446  ELQEMKKEEKEDCPEVPHKAQE 467
            ELQ  +    E   ++    QE
Sbjct: 1545 ELQSKRASFAEKTAQLERSLQE 1566



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 82/418 (19%), Positives = 159/418 (38%), Gaps = 75/418 (17%)

Query: 118  VPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR 177
            + GT    E    ++E ++  +++     +++  +  L++L  +   +    + L D  R
Sbjct: 1063 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1122

Query: 178  GTDFV-RTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAM 236
            G   V   L ++  +    +   ++R+ +L ++ +         QTD++   LE++   +
Sbjct: 1123 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV-----LAQTDVRQRELEQLGRQL 1177

Query: 237  ETYYEEVHRLQTLLASS----ETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEEN 292
              Y E    L   L  +    E     PL + +   + Q +   ALL       E  EE 
Sbjct: 1178 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQA-VREQLRQEQALLEEIERHGEKVEEC 1236

Query: 293  Q------------------SLKEDLDRVLST-------SPTISKTQGYVE----WSKPRL 323
            Q                  + K  L+ V S        S + S  Q YV+    +S+   
Sbjct: 1237 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1296

Query: 324  L--RRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAV 381
            L  + I  + + L  ME  +   AE  R+     LA   A   + R       +    A 
Sbjct: 1297 LTSQYIKFISETLRRMEEEE-RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1355

Query: 382  RDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEE----------ERRER-- 429
            R+ KE +  +QE++++R+       Q K  +++EL+  R+  E          E  ER  
Sbjct: 1356 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1415

Query: 430  ---EEVLRE-----------------EIQTLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
               EE +R                  E+Q L ++ +E +  K++ +E+   +  + Q+
Sbjct: 1416 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1473



 Score = 36.6 bits (83), Expect = 0.078
 Identities = 51/260 (19%), Positives = 97/260 (37%), Gaps = 40/260 (15%)

Query: 201  QRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKP 260
            QR  + E Q K         Q +    +L+E  +A+    EE  R     A  +   ++ 
Sbjct: 1539 QRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR----AQQQAEAERA 1591

Query: 261  LGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSK 320
              E +   +R +   +  L L    +E+ ++    + + ++    +   ++ +G  E   
Sbjct: 1592 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1651

Query: 321  PRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGA 380
             R        +++L+  E  K              LA  +A   Q R    ++  RLR  
Sbjct: 1652 VR--------QRELAEQELEKQRQ-----------LAEGTA---QQRLAAEQELIRLRAE 1689

Query: 381  VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR-----------EGEEERRER 429
                +++R  L+E+L +   E     Q + +LE EL   R             EEE R  
Sbjct: 1690 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1749

Query: 430  EEVLREEIQTLTSKLQELQE 449
             E  ++ ++    + +EL E
Sbjct: 1750 SEKSKQRLEAEAGRFRELAE 1769



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 31/180 (17%), Positives = 73/180 (40%), Gaps = 11/180 (6%)

Query: 281  LSRSVQELTEEN----QSLKEDLDRVLSTSPTISKTQGYVE---WSKPRLLRRIVELEKK 333
            +S +++ + EE     Q   E+ +R+      + K +   E    +K +  R   EL+++
Sbjct: 1305 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1364

Query: 334  LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
            +      +  AA   +    +       L +    +      +   A R     R  ++E
Sbjct: 1365 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS----RLRIEE 1420

Query: 394  QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
            ++    L+++   + +   E EL+  R   EE   ++   +EE + L  ++Q+  + K++
Sbjct: 1421 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1480


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 69/347 (19%), Positives = 147/347 (42%), Gaps = 27/347 (7%)

Query: 125  REKEDMYDEIIELKKSLH---VQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF 181
            R++  + +EI+ LK S       K++++L   ++R   E+  R   Q E  L+ +R    
Sbjct: 2055 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAARQRQL 2112

Query: 182  VRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
                  +R +A   +    Q+ L  E++   +           +   LEE+   ++   E
Sbjct: 2113 AAEEERRRREAEERV----QKSLAAEEEAARQ-----------RKAALEEVE-RLKAKVE 2156

Query: 242  EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDR 301
            E  RL+   A  E+  +  L ++    + Q +  +   ++ +  QEL +  Q  +  LD+
Sbjct: 2157 EARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2215

Query: 302  VLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
            +   +    +     E ++ +  R   +  +++   E  K  A E  ++      A + A
Sbjct: 2216 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-----AQAQA 2270

Query: 362  LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
               + R +  ++  R   A +    ++ A   ++ +     +Q L+ KA +E+EL   R 
Sbjct: 2271 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2330

Query: 422  GEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
              EE   ++ +L EE+Q L ++  E    + + +E+   V  + +EL
Sbjct: 2331 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2377



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 80/384 (20%), Positives = 161/384 (41%), Gaps = 60/384 (15%)

Query: 125  REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
            +EK     E   LK    + +   +L + + RRL+E+   K++  +QL + ++G  F RT
Sbjct: 2450 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQG--FQRT 2504

Query: 185  LAEKRPDASWVINGLKQRILKLE---QQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
            L  +R           QR L++    ++ K +   +S+ Q   +  + +  R   E   E
Sbjct: 2505 LEAER-----------QRQLEMSAEAERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGE 2552

Query: 242  EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQ--SLKEDL 299
            ++HR +       T  +    +++      +++  A+  L R  ++L +E +   LK + 
Sbjct: 2553 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2612

Query: 300  DRVLSTSPTISKTQGYVEW---SKPRLLRR--IVELEK-KLSVMESSKSHAAEPVRSHPP 353
             + +     + +TQ   +     K  LL+R   +E EK KL  +   +   A+ +R    
Sbjct: 2613 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-- 2670

Query: 354  ACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE 413
                      ++ +    ++ +RL  ++ + +  +   +E + ++  E++QL        
Sbjct: 2671 ---------QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL-------- 2713

Query: 414  KELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTP 473
                     E++RR++EE+L EE Q L  +LQ L+E  +       EV           P
Sbjct: 2714 ---------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2764

Query: 474  SSRHC----EQDWPPDSSEEGLPR 493
            + R        +  P+ S +GL R
Sbjct: 2765 NGRDALDGPAAEAEPEHSFDGLRR 2788



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 82/370 (22%), Positives = 162/370 (43%), Gaps = 46/370 (12%)

Query: 101  TFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLR---- 156
            +F  K   L RS    HV    +  E E    +  E +++    + +++  + K      
Sbjct: 1721 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1780

Query: 157  -RLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRIL---KLEQQCKE 212
             RL+ E   + + + Q  +  +  +     A +R  A      ++QR L   +LE+Q + 
Sbjct: 1781 LRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQL 1837

Query: 213  KDGTISK--------LQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEK 264
             +GT  +        ++   +T   E+ R  +E   EE+ RLQ   A++  T K+   E 
Sbjct: 1838 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE---EELARLQREAAAA--TQKRQELEA 1892

Query: 265  KTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLL 324
            +  AK + +M   L S +R+ +E    ++  K+ L+        +++     E ++ R L
Sbjct: 1893 EL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRAL 1946

Query: 325  RRIVELEKKLSVMESSKSHA-AEPVRSHPPACLASSSALHRQPR---GDRNKDHERLRGA 380
                + +++L+  ++++  A AE V +   A +  ++ L  +      ++  ++ERLR  
Sbjct: 1947 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 2006

Query: 381  VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTL 440
              D   +R  L+EQ  Q           KAD+E+ L   R+  +   ER++ L E+  TL
Sbjct: 2007 AEDEAFQRRRLEEQAAQH----------KADIEERLAQLRKASDSELERQKGLVED--TL 2054

Query: 441  TSKLQELQEM 450
              + Q  +E+
Sbjct: 2055 RQRRQVEEEI 2064



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 59/271 (21%), Positives = 107/271 (39%), Gaps = 37/271 (13%)

Query: 199  LKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGK 258
            L  R+    +  +EK   +  L+ +++    E  R   +   E   ++Q  L +++ + +
Sbjct: 1654 LASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712

Query: 259  KPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEW 318
              L  K+               L RS+QE       L+E+ +R         + Q   E 
Sbjct: 1713 AELQSKRAS------FAEKTAQLERSLQEEHVAVAQLREEAER---------RAQQQAEA 1757

Query: 319  SKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLR 378
             + R      E E++L   E  +  A E +R    A   +      Q   ++ K+     
Sbjct: 1758 ERAR-----EEAEREL---ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1809

Query: 379  GAVRDLKEERTALQEQLLQRDLEVKQLL-----QAKADLEKELECAREGEEERREREEVL 433
               R   EE+   Q +L +++LE ++ L     Q +   E+EL   R   E+  ++ ++L
Sbjct: 1810 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1869

Query: 434  REEIQTL-------TSKLQELQ-EMKKEEKE 456
             EE+  L       T K QEL+ E+ K   E
Sbjct: 1870 EEELARLQREAAAATQKRQELEAELAKVRAE 1900



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 64/353 (18%), Positives = 137/353 (38%), Gaps = 32/353 (9%)

Query: 145  KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRI- 203
            K   +L   + R+L  E  R+ R+ E+ +  S   +     A +R  A   +  LK ++ 
Sbjct: 2099 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVERLKAKVE 2156

Query: 204  --LKLEQQCKEKDGTISKLQTD--MKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKK 259
               +L ++ +++     +L  +   K    EE   A     +E   LQ  L   ++   +
Sbjct: 2157 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQTLQQEQSVLDQ 2215

Query: 260  PLGEKKTGAKRQKKMGSALLSLSRS-------VQELTEENQSLKEDLDRVLSTSPTISKT 312
              GE +   +  ++   A +   R        V+E     QS +E             K 
Sbjct: 2216 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2275

Query: 313  QGYVEWSKPRLLR-RIVELEKKLSV---MESSKSHAAEPVRSHPPACLASSSALHRQPRG 368
            +   E    R  +     L +K +    ME  K  A + +R         ++   +    
Sbjct: 2276 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2335

Query: 369  DRNK-----DHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE--------KE 415
            D  K     + +RL+    +   +R+ ++E+L    +++++L + KA +E        ++
Sbjct: 2336 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2395

Query: 416  LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
             +  +   +E  E+ + + EE   L+   QE   +++  +ED  +    A+++
Sbjct: 2396 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2448



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 60/262 (22%), Positives = 108/262 (41%), Gaps = 33/262 (12%)

Query: 230  EEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQ---------KKMGSALLS 280
            EE R+A +   EE  RL  + A+ E   ++ L E    AK Q         ++M   ++ 
Sbjct: 1483 EEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540

Query: 281  LSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGY----VEWSKPRLLRRIVELEKKLSV 336
               +  +  ++ +S++E+L ++  +S    + +       E S+ R+   I  +  +L  
Sbjct: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1600

Query: 337  MESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLL 396
             E  +  A   ++    A  A +     Q R    ++ ERLR  V+D  + +   + +L 
Sbjct: 1601 TERQRGGAEGELQ----ALRARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELA 1655

Query: 397  QR-------DLEVKQLLQAKADLEKELECA----REGEEERREREEVLREEIQTLTSKLQ 445
             R         E ++ LQA  +L  + E A    R+ E ER  + +V  E  Q   S   
Sbjct: 1656 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEA 1713

Query: 446  ELQEMKKEEKEDCPEVPHKAQE 467
            ELQ  +    E   ++    QE
Sbjct: 1714 ELQSKRASFAEKTAQLERSLQE 1735



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 82/418 (19%), Positives = 159/418 (38%), Gaps = 75/418 (17%)

Query: 118  VPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR 177
            + GT    E    ++E ++  +++     +++  +  L++L  +   +    + L D  R
Sbjct: 1232 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1291

Query: 178  GTDFV-RTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAM 236
            G   V   L ++  +    +   ++R+ +L ++ +         QTD++   LE++   +
Sbjct: 1292 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV-----LAQTDVRQRELEQLGRQL 1346

Query: 237  ETYYEEVHRLQTLLASS----ETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEEN 292
              Y E    L   L  +    E     PL + +   + Q +   ALL       E  EE 
Sbjct: 1347 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQA-VREQLRQEQALLEEIERHGEKVEEC 1405

Query: 293  Q------------------SLKEDLDRVLST-------SPTISKTQGYVE----WSKPRL 323
            Q                  + K  L+ V S        S + S  Q YV+    +S+   
Sbjct: 1406 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1465

Query: 324  L--RRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAV 381
            L  + I  + + L  ME  +   AE  R+     LA   A   + R       +    A 
Sbjct: 1466 LTSQYIKFISETLRRMEEEE-RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1524

Query: 382  RDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEE----------ERRER-- 429
            R+ KE +  +QE++++R+       Q K  +++EL+  R+  E          E  ER  
Sbjct: 1525 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1584

Query: 430  ---EEVLRE-----------------EIQTLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
               EE +R                  E+Q L ++ +E +  K++ +E+   +  + Q+
Sbjct: 1585 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1642



 Score = 36.6 bits (83), Expect = 0.078
 Identities = 51/260 (19%), Positives = 97/260 (37%), Gaps = 40/260 (15%)

Query: 201  QRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKP 260
            QR  + E Q K         Q +    +L+E  +A+    EE  R     A  +   ++ 
Sbjct: 1708 QRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR----AQQQAEAERA 1760

Query: 261  LGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSK 320
              E +   +R +   +  L L    +E+ ++    + + ++    +   ++ +G  E   
Sbjct: 1761 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1820

Query: 321  PRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGA 380
             R        +++L+  E  K              LA  +A   Q R    ++  RLR  
Sbjct: 1821 VR--------QRELAEQELEKQRQ-----------LAEGTA---QQRLAAEQELIRLRAE 1858

Query: 381  VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR-----------EGEEERRER 429
                +++R  L+E+L +   E     Q + +LE EL   R             EEE R  
Sbjct: 1859 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1918

Query: 430  EEVLREEIQTLTSKLQELQE 449
             E  ++ ++    + +EL E
Sbjct: 1919 SEKSKQRLEAEAGRFRELAE 1938



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 31/180 (17%), Positives = 73/180 (40%), Gaps = 11/180 (6%)

Query: 281  LSRSVQELTEEN----QSLKEDLDRVLSTSPTISKTQGYVE---WSKPRLLRRIVELEKK 333
            +S +++ + EE     Q   E+ +R+      + K +   E    +K +  R   EL+++
Sbjct: 1474 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1533

Query: 334  LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
            +      +  AA   +    +       L +    +      +   A R     R  ++E
Sbjct: 1534 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS----RLRIEE 1589

Query: 394  QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
            ++    L+++   + +   E EL+  R   EE   ++   +EE + L  ++Q+  + K++
Sbjct: 1590 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1649


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 69/347 (19%), Positives = 147/347 (42%), Gaps = 27/347 (7%)

Query: 125  REKEDMYDEIIELKKSLH---VQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDF 181
            R++  + +EI+ LK S       K++++L   ++R   E+  R   Q E  L+ +R    
Sbjct: 1896 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAARQRQL 1953

Query: 182  VRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
                  +R +A   +    Q+ L  E++   +           +   LEE+   ++   E
Sbjct: 1954 AAEEERRRREAEERV----QKSLAAEEEAARQ-----------RKAALEEVE-RLKAKVE 1997

Query: 242  EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDR 301
            E  RL+   A  E+  +  L ++    + Q +  +   ++ +  QEL +  Q  +  LD+
Sbjct: 1998 EARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2056

Query: 302  VLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSA 361
            +   +    +     E ++ +  R   +  +++   E  K  A E  ++      A + A
Sbjct: 2057 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR-----AQAQA 2111

Query: 362  LHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECARE 421
               + R +  ++  R   A +    ++ A   ++ +     +Q L+ KA +E+EL   R 
Sbjct: 2112 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2171

Query: 422  GEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
              EE   ++ +L EE+Q L ++  E    + + +E+   V  + +EL
Sbjct: 2172 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2218



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 80/384 (20%), Positives = 161/384 (41%), Gaps = 60/384 (15%)

Query: 125  REKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRT 184
            +EK     E   LK    + +   +L + + RRL+E+   K++  +QL + ++G  F RT
Sbjct: 2291 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED---KEQMAQQLAEETQG--FQRT 2345

Query: 185  LAEKRPDASWVINGLKQRILKLE---QQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYE 241
            L  +R           QR L++    ++ K +   +S+ Q   +  + +  R   E   E
Sbjct: 2346 LEAER-----------QRQLEMSAEAERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGE 2393

Query: 242  EVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQ--SLKEDL 299
            ++HR +       T  +    +++      +++  A+  L R  ++L +E +   LK + 
Sbjct: 2394 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2453

Query: 300  DRVLSTSPTISKTQGYVEW---SKPRLLRR--IVELEK-KLSVMESSKSHAAEPVRSHPP 353
             + +     + +TQ   +     K  LL+R   +E EK KL  +   +   A+ +R    
Sbjct: 2454 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE-- 2511

Query: 354  ACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE 413
                      ++ +    ++ +RL  ++ + +  +   +E + ++  E++QL        
Sbjct: 2512 ---------QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL-------- 2554

Query: 414  KELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTP 473
                     E++RR++EE+L EE Q L  +LQ L+E  +       EV           P
Sbjct: 2555 ---------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2605

Query: 474  SSRHC----EQDWPPDSSEEGLPR 493
            + R        +  P+ S +GL R
Sbjct: 2606 NGRDALDGPAAEAEPEHSFDGLRR 2629



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 82/370 (22%), Positives = 162/370 (43%), Gaps = 46/370 (12%)

Query: 101  TFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLR---- 156
            +F  K   L RS    HV    +  E E    +  E +++    + +++  + K      
Sbjct: 1562 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1621

Query: 157  -RLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRIL---KLEQQCKE 212
             RL+ E   + + + Q  +  +  +     A +R  A      ++QR L   +LE+Q + 
Sbjct: 1622 LRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEE--QAVRQRELAEQELEKQRQL 1678

Query: 213  KDGTISK--------LQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEK 264
             +GT  +        ++   +T   E+ R  +E   EE+ RLQ   A++  T K+   E 
Sbjct: 1679 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE---EELARLQREAAAA--TQKRQELEA 1733

Query: 265  KTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLL 324
            +  AK + +M   L S +R+ +E    ++  K+ L+        +++     E ++ R L
Sbjct: 1734 EL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRAL 1787

Query: 325  RRIVELEKKLSVMESSKSHA-AEPVRSHPPACLASSSALHRQPR---GDRNKDHERLRGA 380
                + +++L+  ++++  A AE V +   A +  ++ L  +      ++  ++ERLR  
Sbjct: 1788 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1847

Query: 381  VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTL 440
              D   +R  L+EQ  Q           KAD+E+ L   R+  +   ER++ L E+  TL
Sbjct: 1848 AEDEAFQRRRLEEQAAQH----------KADIEERLAQLRKASDSELERQKGLVED--TL 1895

Query: 441  TSKLQELQEM 450
              + Q  +E+
Sbjct: 1896 RQRRQVEEEI 1905



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 59/271 (21%), Positives = 107/271 (39%), Gaps = 37/271 (13%)

Query: 199  LKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGK 258
            L  R+    +  +EK   +  L+ +++    E  R   +   E   ++Q  L +++ + +
Sbjct: 1495 LASRVKAEAEAAREKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553

Query: 259  KPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEW 318
              L  K+               L RS+QE       L+E+ +R         + Q   E 
Sbjct: 1554 AELQSKRAS------FAEKTAQLERSLQEEHVAVAQLREEAER---------RAQQQAEA 1598

Query: 319  SKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLR 378
             + R      E E++L   E  +  A E +R    A   +      Q   ++ K+     
Sbjct: 1599 ERAR-----EEAEREL---ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1650

Query: 379  GAVRDLKEERTALQEQLLQRDLEVKQLL-----QAKADLEKELECAREGEEERREREEVL 433
               R   EE+   Q +L +++LE ++ L     Q +   E+EL   R   E+  ++ ++L
Sbjct: 1651 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1710

Query: 434  REEIQTL-------TSKLQELQ-EMKKEEKE 456
             EE+  L       T K QEL+ E+ K   E
Sbjct: 1711 EEELARLQREAAAATQKRQELEAELAKVRAE 1741



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 64/353 (18%), Positives = 137/353 (38%), Gaps = 32/353 (9%)

Query: 145  KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRI- 203
            K   +L   + R+L  E  R+ R+ E+ +  S   +     A +R  A   +  LK ++ 
Sbjct: 1940 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVERLKAKVE 1997

Query: 204  --LKLEQQCKEKDGTISKLQTD--MKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKK 259
               +L ++ +++     +L  +   K    EE   A     +E   LQ  L   ++   +
Sbjct: 1998 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQTLQQEQSVLDQ 2056

Query: 260  PLGEKKTGAKRQKKMGSALLSLSRS-------VQELTEENQSLKEDLDRVLSTSPTISKT 312
              GE +   +  ++   A +   R        V+E     QS +E             K 
Sbjct: 2057 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2116

Query: 313  QGYVEWSKPRLLR-RIVELEKKLSV---MESSKSHAAEPVRSHPPACLASSSALHRQPRG 368
            +   E    R  +     L +K +    ME  K  A + +R         ++   +    
Sbjct: 2117 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2176

Query: 369  DRNK-----DHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLE--------KE 415
            D  K     + +RL+    +   +R+ ++E+L    +++++L + KA +E        ++
Sbjct: 2177 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2236

Query: 416  LECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQEL 468
             +  +   +E  E+ + + EE   L+   QE   +++  +ED  +    A+++
Sbjct: 2237 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2289



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 60/262 (22%), Positives = 108/262 (41%), Gaps = 33/262 (12%)

Query: 230  EEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQ---------KKMGSALLS 280
            EE R+A +   EE  RL  + A+ E   ++ L E    AK Q         ++M   ++ 
Sbjct: 1324 EEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381

Query: 281  LSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGY----VEWSKPRLLRRIVELEKKLSV 336
               +  +  ++ +S++E+L ++  +S    + +       E S+ R+   I  +  +L  
Sbjct: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1441

Query: 337  MESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLL 396
             E  +  A   ++    A  A +     Q R    ++ ERLR  V+D  + +   + +L 
Sbjct: 1442 TERQRGGAEGELQ----ALRARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELA 1496

Query: 397  QR-------DLEVKQLLQAKADLEKELECA----REGEEERREREEVLREEIQTLTSKLQ 445
             R         E ++ LQA  +L  + E A    R+ E ER  + +V  E  Q   S   
Sbjct: 1497 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEA 1554

Query: 446  ELQEMKKEEKEDCPEVPHKAQE 467
            ELQ  +    E   ++    QE
Sbjct: 1555 ELQSKRASFAEKTAQLERSLQE 1576



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 82/418 (19%), Positives = 159/418 (38%), Gaps = 75/418 (17%)

Query: 118  VPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSR 177
            + GT    E    ++E ++  +++     +++  +  L++L  +   +    + L D  R
Sbjct: 1073 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1132

Query: 178  GTDFV-RTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAM 236
            G   V   L ++  +    +   ++R+ +L ++ +         QTD++   LE++   +
Sbjct: 1133 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV-----LAQTDVRQRELEQLGRQL 1187

Query: 237  ETYYEEVHRLQTLLASS----ETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEEN 292
              Y E    L   L  +    E     PL + +   + Q +   ALL       E  EE 
Sbjct: 1188 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQA-VREQLRQEQALLEEIERHGEKVEEC 1246

Query: 293  Q------------------SLKEDLDRVLST-------SPTISKTQGYVE----WSKPRL 323
            Q                  + K  L+ V S        S + S  Q YV+    +S+   
Sbjct: 1247 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1306

Query: 324  L--RRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAV 381
            L  + I  + + L  ME  +   AE  R+     LA   A   + R       +    A 
Sbjct: 1307 LTSQYIKFISETLRRMEEEE-RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1365

Query: 382  RDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEE----------ERRER-- 429
            R+ KE +  +QE++++R+       Q K  +++EL+  R+  E          E  ER  
Sbjct: 1366 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1425

Query: 430  ---EEVLRE-----------------EIQTLTSKLQELQEMKKEEKEDCPEVPHKAQE 467
               EE +R                  E+Q L ++ +E +  K++ +E+   +  + Q+
Sbjct: 1426 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1483



 Score = 36.6 bits (83), Expect = 0.078
 Identities = 51/260 (19%), Positives = 97/260 (37%), Gaps = 40/260 (15%)

Query: 201  QRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKP 260
            QR  + E Q K         Q +    +L+E  +A+    EE  R     A  +   ++ 
Sbjct: 1549 QRSAEAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERR----AQQQAEAERA 1601

Query: 261  LGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSK 320
              E +   +R +   +  L L    +E+ ++    + + ++    +   ++ +G  E   
Sbjct: 1602 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1661

Query: 321  PRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGA 380
             R        +++L+  E  K              LA  +A   Q R    ++  RLR  
Sbjct: 1662 VR--------QRELAEQELEKQRQ-----------LAEGTA---QQRLAAEQELIRLRAE 1699

Query: 381  VRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAR-----------EGEEERRER 429
                +++R  L+E+L +   E     Q + +LE EL   R             EEE R  
Sbjct: 1700 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1759

Query: 430  EEVLREEIQTLTSKLQELQE 449
             E  ++ ++    + +EL E
Sbjct: 1760 SEKSKQRLEAEAGRFRELAE 1779



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 31/180 (17%), Positives = 73/180 (40%), Gaps = 11/180 (6%)

Query: 281  LSRSVQELTEEN----QSLKEDLDRVLSTSPTISKTQGYVE---WSKPRLLRRIVELEKK 333
            +S +++ + EE     Q   E+ +R+      + K +   E    +K +  R   EL+++
Sbjct: 1315 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1374

Query: 334  LSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQE 393
            +      +  AA   +    +       L +    +      +   A R     R  ++E
Sbjct: 1375 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS----RLRIEE 1430

Query: 394  QLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKE 453
            ++    L+++   + +   E EL+  R   EE   ++   +EE + L  ++Q+  + K++
Sbjct: 1431 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1490


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.127    0.364 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,947,642
Number of Sequences: 37866
Number of extensions: 1634162
Number of successful extensions: 18970
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 434
Number of HSP's successfully gapped in prelim test: 1037
Number of HSP's that attempted gapping in prelim test: 10102
Number of HSP's gapped (non-prelim): 5783
length of query: 679
length of database: 18,247,518
effective HSP length: 109
effective length of query: 570
effective length of database: 14,120,124
effective search space: 8048470680
effective search space used: 8048470680
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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