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Search of human proteins with 15451902
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15451902 mitogen-activated protein kinase kinase kinase
kinase 3 [Homo sapiens]
(894 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 1848 0.0
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 1174 0.0
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 1174 0.0
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 906 0.0
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 720 0.0
gi|6005810 mitogen-activated protein kinase kinase kinase kinase... 696 0.0
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 268 2e-71
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 267 3e-71
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 267 3e-71
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 267 3e-71
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 266 5e-71
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 266 8e-71
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 266 8e-71
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 266 8e-71
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 266 8e-71
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 266 8e-71
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 266 8e-71
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 266 8e-71
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 266 8e-71
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 262 1e-69
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 262 1e-69
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 262 1e-69
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 262 1e-69
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 262 1e-69
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 261 2e-69
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 259 1e-68
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 256 7e-68
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 244 3e-64
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 240 5e-63
gi|145275208 myosin IIIA [Homo sapiens] 239 1e-62
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 1848 bits (4786), Expect = 0.0
Identities = 894/894 (100%), Positives = 894/894 (100%)
Query: 1 MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQ 60
MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQ
Sbjct: 1 MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQ 60
Query: 61 EIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRET 120
EIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRET
Sbjct: 61 EIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRET 120
Query: 121 LQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAP 180
LQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAP
Sbjct: 121 LQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAP 180
Query: 181 EVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKM 240
EVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKM
Sbjct: 181 EVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKM 240
Query: 241 KWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDF 300
KWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDF
Sbjct: 241 KWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDF 300
Query: 301 DDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLD 360
DDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLD
Sbjct: 301 DDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLD 360
Query: 361 SSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDD 420
SSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDD
Sbjct: 361 SSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDD 420
Query: 421 ESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPP 480
ESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPP
Sbjct: 421 ESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPP 480
Query: 481 PRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTP 540
PRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTP
Sbjct: 481 PRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTP 540
Query: 541 KVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLF 600
KVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLF
Sbjct: 541 KVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLF 600
Query: 601 PRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKF 660
PRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKF
Sbjct: 601 PRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKF 660
Query: 661 SVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPC 720
SVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPC
Sbjct: 661 SVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPC 720
Query: 721 PLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVT 780
PLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVT
Sbjct: 721 PLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVT 780
Query: 781 QLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQG 840
QLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQG
Sbjct: 781 QLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQG 840
Query: 841 RSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY 894
RSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY
Sbjct: 841 RSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY 894
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 1174 bits (3036), Expect = 0.0
Identities = 592/899 (65%), Positives = 704/899 (78%), Gaps = 62/899 (6%)
Query: 1 MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQ 60
+ P D+ RRNPQ+D+EL+QR+GSGTYGDVYKARNV+TGELAA+K+IKLEPG+DF+++QQ
Sbjct: 5 LRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQ 64
Query: 61 EIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRET 120
EI M+K+CKH NIVAYFGSYL R+KLWICME+CGGGSLQDIYHVTGPLSELQIAYV RET
Sbjct: 65 EIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRET 124
Query: 121 LQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAP 180
LQGL YLH+KGKMHRDIKGANILLTD+G VKLADFGV+A+ITATIAKRKSFIGTPYWMAP
Sbjct: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
Query: 181 EVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKM 240
EVAAVE+ GGYNQLCD+WAVGITAIEL ELQPPMFDLHPMRALFLM+KSNFQPPKLKDK
Sbjct: 185 EVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKT 244
Query: 241 KWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQH-LTRSLAIELLDKVNNPD-HSTYH 298
KWS++FH+FVK+ALTKNPKKRPTAE+LL H FV Q L+R+LA+ELLDKVNNPD H+ Y
Sbjct: 245 KWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYT 304
Query: 299 DFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGF 358
+ DDDD EP + H I ST+RN R E+T SEI F +++F+PPLRKETE E+ S
Sbjct: 305 EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGLS--- 361
Query: 359 LDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGD 418
S+ + L++ + GAN
Sbjct: 362 ------------SDPNFMLQWNP-----FVDGANTG------------------------ 380
Query: 419 DDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRP 478
ST K IPPPLPPKP+ P++ + ++E TIK CP S S A P + +
Sbjct: 381 -----KSTSKRAIPPPLPPKPRISSYPED-NFPDEEKASTIKHCPDSESRA-PQILRRQS 433
Query: 479 PPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPP 538
P P + ++GNG +L E Q R +K+K+D PKP NGLPP
Sbjct: 434 SPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPR-----KKDKRDFPKPAINGLPP 488
Query: 539 TPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQ 598
TPKV MGACFSKVF+GCPLKI+CA+SWI+PDT+DQY+IFG E+GIYTLNLNELHE +MEQ
Sbjct: 489 TPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQ 548
Query: 599 LFPRRCTWLYVMNNCLLSIS-GKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILP 657
LFPR+CTWLYV+NN L+S+S GK QLYSHNL LF++A++ L I H+ PDRILP
Sbjct: 549 LFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKK-PGLAAHIQTHRFPDRILP 607
Query: 658 RKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFP 717
RKF+++ KIP+TK C KCC+VRNPYTGHKYLCGALQ+ IVLL+W EPMQKFMLIKH DFP
Sbjct: 608 RKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFP 667
Query: 718 IPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTE--SDTPQTN 775
+P PL +FEMLV+PEQEYP+VCV +S+G + NQVV+FET+N NS SSWFTE + + Q +
Sbjct: 668 LPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIGAGSQQLD 727
Query: 776 VTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWK 835
HVTQLERDT+LVCLD +KIVNLQG+LKSS+KL+SEL+FDF+IES+VCLQDSVLAFWK
Sbjct: 728 SIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQDSVLAFWK 787
Query: 836 HGMQGRSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY 894
HGMQG+SF+S+EVTQEISD TR+FRLLGSDRVVVLESRPT+NPTA+SNLYILAGHENSY
Sbjct: 788 HGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILAGHENSY 846
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 1174 bits (3036), Expect = 0.0
Identities = 592/899 (65%), Positives = 704/899 (78%), Gaps = 62/899 (6%)
Query: 1 MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQ 60
+ P D+ RRNPQ+D+EL+QR+GSGTYGDVYKARNV+TGELAA+K+IKLEPG+DF+++QQ
Sbjct: 5 LRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQ 64
Query: 61 EIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRET 120
EI M+K+CKH NIVAYFGSYL R+KLWICME+CGGGSLQDIYHVTGPLSELQIAYV RET
Sbjct: 65 EIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRET 124
Query: 121 LQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAP 180
LQGL YLH+KGKMHRDIKGANILLTD+G VKLADFGV+A+ITATIAKRKSFIGTPYWMAP
Sbjct: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
Query: 181 EVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKM 240
EVAAVE+ GGYNQLCD+WAVGITAIEL ELQPPMFDLHPMRALFLM+KSNFQPPKLKDK
Sbjct: 185 EVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKT 244
Query: 241 KWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQH-LTRSLAIELLDKVNNPD-HSTYH 298
KWS++FH+FVK+ALTKNPKKRPTAE+LL H FV Q L+R+LA+ELLDKVNNPD H+ Y
Sbjct: 245 KWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYT 304
Query: 299 DFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGF 358
+ DDDD EP + H I ST+RN R E+T SEI F +++F+PPLRKETE E+ S
Sbjct: 305 EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGLS--- 361
Query: 359 LDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGD 418
S+ + L++ + GAN
Sbjct: 362 ------------SDPNFMLQWNP-----FVDGANTG------------------------ 380
Query: 419 DDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRP 478
ST K IPPPLPPKP+ P++ + ++E TIK CP S S A P + +
Sbjct: 381 -----KSTSKRAIPPPLPPKPRISSYPED-NFPDEEKASTIKHCPDSESRA-PQILRRQS 433
Query: 479 PPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPP 538
P P + ++GNG +L E Q R +K+K+D PKP NGLPP
Sbjct: 434 SPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPR-----KKDKRDFPKPAINGLPP 488
Query: 539 TPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQ 598
TPKV MGACFSKVF+GCPLKI+CA+SWI+PDT+DQY+IFG E+GIYTLNLNELHE +MEQ
Sbjct: 489 TPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQ 548
Query: 599 LFPRRCTWLYVMNNCLLSIS-GKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILP 657
LFPR+CTWLYV+NN L+S+S GK QLYSHNL LF++A++ L I H+ PDRILP
Sbjct: 549 LFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKK-PGLAAHIQTHRFPDRILP 607
Query: 658 RKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFP 717
RKF+++ KIP+TK C KCC+VRNPYTGHKYLCGALQ+ IVLL+W EPMQKFMLIKH DFP
Sbjct: 608 RKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFP 667
Query: 718 IPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTE--SDTPQTN 775
+P PL +FEMLV+PEQEYP+VCV +S+G + NQVV+FET+N NS SSWFTE + + Q +
Sbjct: 668 LPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIGAGSQQLD 727
Query: 776 VTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWK 835
HVTQLERDT+LVCLD +KIVNLQG+LKSS+KL+SEL+FDF+IES+VCLQDSVLAFWK
Sbjct: 728 SIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQDSVLAFWK 787
Query: 836 HGMQGRSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY 894
HGMQG+SF+S+EVTQEISD TR+FRLLGSDRVVVLESRPT+NPTA+SNLYILAGHENSY
Sbjct: 788 HGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILAGHENSY 846
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 906 bits (2342), Expect = 0.0
Identities = 469/893 (52%), Positives = 615/893 (68%), Gaps = 82/893 (9%)
Query: 6 DLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMM 65
D+S ++P++ FEL+QR+G+GTYGDVYKAR+ T ELAA+K++KL+PG+D + +QQEI ++
Sbjct: 6 DVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITIL 65
Query: 66 KDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLY 125
++C+HPN+VAY GSYLR D+LWICMEFCGGGSLQ+IYH TGPL E QIAYV RE L+GL+
Sbjct: 66 RECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLH 125
Query: 126 YLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAV 185
+LHS+GK+HRDIKGAN+LLT G VKLADFGVS ++TA++AKR+SFIGTPYWMAPEVAAV
Sbjct: 126 HLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAV 185
Query: 186 ERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNS 245
ERKGGYN+LCD+WA+GITAIEL ELQPP+F LHPMRAL LM+KS+FQPPKL+DK +W+ +
Sbjct: 186 ERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQN 245
Query: 246 FHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDP 305
FHHF+K+ALTKNPKKRPTAEKLLQHPF TQ L R+L +LLDK ++P H +D +
Sbjct: 246 FHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDP-HLGTPSPEDCEL 304
Query: 306 EPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEI 365
E P IHS ++ E+T SEI F QVKF P RKET+P +E + + L EE+
Sbjct: 305 ETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLGKEEL 364
Query: 366 YYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHS 425
+ SLL+SV+E L +R
Sbjct: 365 --------------------------SGSLLQSVQEALEERS------------------ 380
Query: 426 TLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSG--SPAKPSQVPPRPPPPRL 483
L + S F QE+ S D+ GTIKR P G P++ P PP L
Sbjct: 381 ---------LTIRSASEF--QELDS-PDDTMGTIKRAPFLGPLPTDPPAEEPLSSPPGTL 428
Query: 484 PPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVH 543
PP +G +S L ++ K+++D + +GLPPTPKVH
Sbjct: 429 PPPP-----SGPNSSPLLPTAWATM--------------KQREDPERSSCHGLPPTPKVH 469
Query: 544 MGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRR 603
MGACFSKVFNGCPL+IH A +WI+P TRDQ+L+ GAEEGIYTLNL+ELHE ++E+L R
Sbjct: 470 MGACFSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHEDTLEKLISHR 529
Query: 604 CTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVS 663
C+WLY +NN LLS+SGK++ +++H+LPGLF+ R Q++P++IP ++L RI+PR+F++S
Sbjct: 530 CSWLYCVNNVLLSLSGKSTHIWAHDLPGLFEQRRLQQQVPLSIPTNRLTQRIIPRRFALS 589
Query: 664 AKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLR 723
KIP+TK C +C VVRNPYTG +L AL TS++LL+W EP+QKF+L+K+ P+P P
Sbjct: 590 TKIPDTKGCLQCRVVRNPYTGATFLLAALPTSLLLLQWYEPLQKFLLLKNFSSPLPSPAG 649
Query: 724 MFEMLVVPEQEYPLVCVGVS--RGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQ 781
M E LV+ +E P VCVG G + + T + + V Q
Sbjct: 650 MLEPLVLDGKELPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIPPEGIPGSAQQVIQ 709
Query: 782 LERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGR 841
++RDTILV + C++IVN+QG + + L+ ELTFDF IE++VCLQDSVLAFW HGMQGR
Sbjct: 710 VDRDTILVSFERCVRIVNMQG--EPTATLAPELTFDFPIETVVCLQDSVLAFWSHGMQGR 767
Query: 842 SFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY 894
S +NEVTQEI+D TRIFR+LG+ R ++LES PTDNP A+SNLYIL GH+++Y
Sbjct: 768 SLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPEAHSNLYILTGHQSTY 820
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 720 bits (1858), Expect = 0.0
Identities = 399/890 (44%), Positives = 542/890 (60%), Gaps = 86/890 (9%)
Query: 6 DLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMM 65
D+ R+P++ ++L+QR+G GTYG+V+KAR+ +G+L A+K++K+EP +D + +Q+EI+++
Sbjct: 7 DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 66
Query: 66 KDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLY 125
K C+H NIVAY GSYL KLWICMEFCG GSLQDIY VTG LSELQI+YV RE LQGL
Sbjct: 67 KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 126
Query: 126 YLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAV 185
YLHS+ K+HRDIKGANIL+ D G V+LADFG+SAQI AT+A+R SFIGTPYWMAPEVAAV
Sbjct: 127 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV 186
Query: 186 ERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNS 245
KGGYN+LCD+W++GITAIELAELQPP+FD+HP+R LFLMTKS +QPP+LK+K KWS +
Sbjct: 187 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAA 246
Query: 246 FHHFVKMALTKNPKKRPTAEKLLQHPFVTQ-HLTRSLAIELLDKVNNPDHS-TYHDFDDD 303
FH+F+K+ LTK+PKKRP+A K+L H V+Q L R L ++LLDK+ NP + D +D+
Sbjct: 247 FHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDE 306
Query: 304 DPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSE 363
+PE A+P RI ST R+ ++ ++F ET P P + L
Sbjct: 307 EPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRP----PANTARLQPPR 362
Query: 364 EIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESK 423
++ RS+ R ++ DD+ DD +
Sbjct: 363 DL----RSS-------------------------------SPRKQLSESSDDDYDDVDI- 386
Query: 424 HSTLKAKIPPPLPPKPK----SIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPP 479
T PPPLPPKPK S P M + G + RC SG P P+ P PP
Sbjct: 387 -PTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRC-ASGPP--PNSPRPGPP 442
Query: 480 PPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPP- 538
P PH H +L +++ KP LPP
Sbjct: 443 PSTSSPH-------------------------LTAHSEPSLWNPPSRELDKPPL--LPPK 475
Query: 539 TPKVHMGAC--FSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSM 596
K+ C K+FNGCPL+IH ++W +P T+DQ+L+ GAEEGI+ LN N+ E ++
Sbjct: 476 KEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRND-QEATL 534
Query: 597 EQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRIL 656
E LFP R TW+Y +NN L+S+SGK LYSH++ GL + P+ AH P R+L
Sbjct: 535 EMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPI---AHISPHRLL 591
Query: 657 PRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDF 716
RK VS KI +TK C+ CCV +G +LCGAL+TS+VLL+W +PM KF+L++ + F
Sbjct: 592 ARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLF 651
Query: 717 PIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNV 776
P+P PL +F +L P E P VC+GVS GR V+ F TV + S W E T
Sbjct: 652 PLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVL-FHTVRFGALSCWLGEMSTEHRGP 710
Query: 777 THVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKH 836
VTQ+E D ++V +D +K+V +G + + E+ +E++ + + AFWKH
Sbjct: 711 VQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLR-TPEIPMTEAVEAVAMVGGQLQAFWKH 769
Query: 837 GMQGRSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYI 886
G+Q + S+++ QE+ D T FRLLGS R VV+E+RP D+PTA SNLYI
Sbjct: 770 GVQVWALGSDQLLQELRDPTLTFRLLGSPRPVVVETRPVDDPTAPSNLYI 819
>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
isoform 2 [Homo sapiens]
Length = 833
Score = 696 bits (1797), Expect = 0.0
Identities = 394/897 (43%), Positives = 536/897 (59%), Gaps = 92/897 (10%)
Query: 6 DLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMM 65
D+ R+P++ ++L+QR+G GTYG+V+KAR+ +G+L A+K++K+EP +D + +Q+EI+++
Sbjct: 7 DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 66
Query: 66 KDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLY 125
K C+H NIVAY GSYL KLWICMEFCG GSLQDIY VTG LSELQI+YV RE LQGL
Sbjct: 67 KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 126
Query: 126 YLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAV 185
YLHS+ K+HRDIKGANIL+ D G V+LADFG+SAQI AT+A+R SFIGTPYWMAPEVAAV
Sbjct: 127 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV 186
Query: 186 ERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNS 245
KGGYN+LCD+W++GITAIELAELQPP+FD+HP+R LFLMTKS +QPP+LK+K KWS +
Sbjct: 187 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAA 246
Query: 246 FHHFVKMALTKNPKKRPTAEKLLQHPFVTQ-HLTRSLAIELLDKVNNPDHS-TYHDFDDD 303
FH+F+K+ LTK+PKKRP+A K+L H V+Q L R L ++LLDK+ NP + D +D+
Sbjct: 247 FHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDE 306
Query: 304 DPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSE 363
+PE A+P RI ST R+ ++ ++F ET P P + L
Sbjct: 307 EPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRP----PANTARLQPPR 362
Query: 364 EIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESK 423
++ RS+ R ++ DD+ DD +
Sbjct: 363 DL----RSS-------------------------------SPRKQLSESSDDDYDDVDI- 386
Query: 424 HSTLKAKIPPPLPPKPK----SIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPP 479
T PPPLPPKPK S P M + G + RC SG P P+ P PP
Sbjct: 387 -PTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRC-ASGPP--PNSPRPGPP 442
Query: 480 PPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPP- 538
P PH H +L +++ KP LPP
Sbjct: 443 PSTSSPH-------------------------LTAHSEPSLWNPPSRELDKPPL--LPPK 475
Query: 539 TPKVHMGAC--FSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSM 596
K+ C K+FNGCPL+IH ++W +P T+DQ+L+ GAEEGI+ LN N+ E ++
Sbjct: 476 KEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRND-QEATL 534
Query: 597 EQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRIL 656
E LFP R TW+Y +NN L+S+SGK LYSH++ GL + P+ AH P R+L
Sbjct: 535 EMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPI---AHISPHRLL 591
Query: 657 PRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDF 716
RK VS KI +TK C+ CCV +G +LCGAL+TS+VLL+W +PM KF+L++ + F
Sbjct: 592 ARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLF 651
Query: 717 PIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNV 776
P+P PL +F +L P E P VC+GVS GR V+ F TV + S W E T
Sbjct: 652 PLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVL-FHTVRFGALSCWLGEMSTEHRGP 710
Query: 777 THVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKH 836
VTQ+E D ++V +D +K+V +G + + E+ +E++ + + AFWKH
Sbjct: 711 VQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLR-TPEIPMTEAVEAVAMVGGQLQAFWKH 769
Query: 837 GMQGRSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENS 893
G+Q + S+++ QE+ D T FRLLGS R LE T +P N +L G NS
Sbjct: 770 GVQVWALGSDQLLQELRDPTLTFRLLGSPR---LECSGTISPHCN---LLLPGSSNS 820
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 268 bits (685), Expect = 2e-71
Identities = 138/306 (45%), Positives = 197/306 (64%), Gaps = 12/306 (3%)
Query: 6 DLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMM 65
D + P+E F++++++G G+YG VYKA + TG++ AIK + +E D + +EI +M
Sbjct: 20 DSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE--SDLQEIIKEISIM 77
Query: 66 KDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGP-LSELQIAYVSRETLQGL 124
+ C P++V Y+GSY + LWI ME+CG GS+ DI + L+E +IA + + TL+GL
Sbjct: 78 QQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGL 137
Query: 125 YYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAA 184
YLH K+HRDIK NILL GH KLADFGV+ Q+T T+AKR + IGTP+WMAPEV
Sbjct: 138 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI- 196
Query: 185 VERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSN 244
++ GYN + D+W++GITAIE+AE +PP D+HPMRA+F++ + PP + WS+
Sbjct: 197 --QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPELWSD 252
Query: 245 SFHHFVKMALTKNPKKRPTAEKLLQHPFVTQ----HLTRSLAIELLDKVNNPDHSTYHDF 300
+F FVK L K+P++R TA +LLQHPFV + R L E +D S +
Sbjct: 253 NFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREV 312
Query: 301 DDDDPE 306
D DD E
Sbjct: 313 DQDDEE 318
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 267 bits (683), Expect = 3e-71
Identities = 150/338 (44%), Positives = 209/338 (61%), Gaps = 21/338 (6%)
Query: 8 SRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKD 67
S R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + + ++ K
Sbjct: 17 SLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKY 76
Query: 68 CKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYVSRE 119
H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+SRE
Sbjct: 77 SHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISRE 136
Query: 120 TLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMA 179
L+GL +LH +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPYWMA
Sbjct: 137 ILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMA 196
Query: 180 PEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLK 237
PEV A + Y+ DLW+ GITAIE+AE PP+ D+HPMRALFL+ ++ PP+LK
Sbjct: 197 PEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLK 254
Query: 238 DKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN------ 290
K KWS F F++ L KN +RP+ E+LL+HPF+ Q R + I+L D ++
Sbjct: 255 SK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKR 313
Query: 291 -NPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKT 327
D + Y ++ E V S+ NV E T
Sbjct: 314 GEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGEST 351
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 267 bits (683), Expect = 3e-71
Identities = 150/338 (44%), Positives = 209/338 (61%), Gaps = 21/338 (6%)
Query: 8 SRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKD 67
S R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + + ++ K
Sbjct: 17 SLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKY 76
Query: 68 CKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYVSRE 119
H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+SRE
Sbjct: 77 SHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISRE 136
Query: 120 TLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMA 179
L+GL +LH +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPYWMA
Sbjct: 137 ILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMA 196
Query: 180 PEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLK 237
PEV A + Y+ DLW+ GITAIE+AE PP+ D+HPMRALFL+ ++ PP+LK
Sbjct: 197 PEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLK 254
Query: 238 DKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN------ 290
K KWS F F++ L KN +RP+ E+LL+HPF+ Q R + I+L D ++
Sbjct: 255 SK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKR 313
Query: 291 -NPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKT 327
D + Y ++ E V S+ NV E T
Sbjct: 314 GEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGEST 351
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 267 bits (683), Expect = 3e-71
Identities = 150/338 (44%), Positives = 209/338 (61%), Gaps = 21/338 (6%)
Query: 8 SRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKD 67
S R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + + ++ K
Sbjct: 17 SLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKY 76
Query: 68 CKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYVSRE 119
H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+SRE
Sbjct: 77 SHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISRE 136
Query: 120 TLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMA 179
L+GL +LH +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPYWMA
Sbjct: 137 ILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMA 196
Query: 180 PEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLK 237
PEV A + Y+ DLW+ GITAIE+AE PP+ D+HPMRALFL+ ++ PP+LK
Sbjct: 197 PEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLK 254
Query: 238 DKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN------ 290
K KWS F F++ L KN +RP+ E+LL+HPF+ Q R + I+L D ++
Sbjct: 255 SK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKR 313
Query: 291 -NPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKT 327
D + Y ++ E V S+ NV E T
Sbjct: 314 GEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGEST 351
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 266 bits (681), Expect = 5e-71
Identities = 142/283 (50%), Positives = 195/283 (68%), Gaps = 10/283 (3%)
Query: 8 SRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGED-FAVVQQEIIMMK 66
SR +P+E F + RIG G++G+VYK + +T E+ AIK+I LE ED +QQEI ++
Sbjct: 12 SRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLS 71
Query: 67 DCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYY 126
C P I YFGSYL+ KLWI ME+ GGGS D+ GPL E IA + RE L+GL Y
Sbjct: 72 QCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK-PGPLEETYIATILREILKGLDY 130
Query: 127 LHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE 186
LHS+ K+HRDIK AN+LL++ G VKLADFGV+ Q+T T KR +F+GTP+WMAPEV
Sbjct: 131 LHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI--- 187
Query: 187 RKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSF 246
++ Y+ D+W++GITAIELA+ +PP DLHPMR LFL+ K++ PP L+ + S F
Sbjct: 188 KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNS--PPTLEG--QHSKPF 243
Query: 247 HHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTR-SLAIELLDK 288
FV+ L K+P+ RPTA++LL+H F+T++ + S EL+D+
Sbjct: 244 KEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDR 286
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 266 bits (679), Expect = 8e-71
Identities = 141/297 (47%), Positives = 197/297 (66%), Gaps = 15/297 (5%)
Query: 6 DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64
DLS R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + Q+ ++
Sbjct: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINML 73
Query: 65 MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116
K H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+
Sbjct: 74 KKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYI 133
Query: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
RE L+GL +LH +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPY
Sbjct: 134 CREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
Query: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234
WMAPEV A + Y+ DLW++GITAIE+AE PP+ D+HPMRALFL+ ++ P
Sbjct: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAP 251
Query: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN 290
+LK K KWS F F++ L KN +RP E+L++HPF+ Q R + I+L D ++
Sbjct: 252 RLKSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHID 307
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 266 bits (679), Expect = 8e-71
Identities = 141/297 (47%), Positives = 197/297 (66%), Gaps = 15/297 (5%)
Query: 6 DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64
DLS R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + Q+ ++
Sbjct: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINML 73
Query: 65 MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116
K H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+
Sbjct: 74 KKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYI 133
Query: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
RE L+GL +LH +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPY
Sbjct: 134 CREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
Query: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234
WMAPEV A + Y+ DLW++GITAIE+AE PP+ D+HPMRALFL+ ++ P
Sbjct: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAP 251
Query: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN 290
+LK K KWS F F++ L KN +RP E+L++HPF+ Q R + I+L D ++
Sbjct: 252 RLKSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHID 307
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 266 bits (679), Expect = 8e-71
Identities = 141/297 (47%), Positives = 197/297 (66%), Gaps = 15/297 (5%)
Query: 6 DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64
DLS R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + Q+ ++
Sbjct: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINML 73
Query: 65 MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116
K H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+
Sbjct: 74 KKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYI 133
Query: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
RE L+GL +LH +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPY
Sbjct: 134 CREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
Query: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234
WMAPEV A + Y+ DLW++GITAIE+AE PP+ D+HPMRALFL+ ++ P
Sbjct: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAP 251
Query: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN 290
+LK K KWS F F++ L KN +RP E+L++HPF+ Q R + I+L D ++
Sbjct: 252 RLKSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHID 307
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 266 bits (679), Expect = 8e-71
Identities = 141/297 (47%), Positives = 197/297 (66%), Gaps = 15/297 (5%)
Query: 6 DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64
DLS R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + Q+ ++
Sbjct: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINML 73
Query: 65 MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116
K H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+
Sbjct: 74 KKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYI 133
Query: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
RE L+GL +LH +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPY
Sbjct: 134 CREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
Query: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234
WMAPEV A + Y+ DLW++GITAIE+AE PP+ D+HPMRALFL+ ++ P
Sbjct: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAP 251
Query: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN 290
+LK K KWS F F++ L KN +RP E+L++HPF+ Q R + I+L D ++
Sbjct: 252 RLKSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHID 307
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 266 bits (679), Expect = 8e-71
Identities = 141/297 (47%), Positives = 197/297 (66%), Gaps = 15/297 (5%)
Query: 6 DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64
DLS R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + Q+ ++
Sbjct: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINML 73
Query: 65 MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116
K H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+
Sbjct: 74 KKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYI 133
Query: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
RE L+GL +LH +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPY
Sbjct: 134 CREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
Query: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234
WMAPEV A + Y+ DLW++GITAIE+AE PP+ D+HPMRALFL+ ++ P
Sbjct: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAP 251
Query: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN 290
+LK K KWS F F++ L KN +RP E+L++HPF+ Q R + I+L D ++
Sbjct: 252 RLKSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHID 307
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 266 bits (679), Expect = 8e-71
Identities = 141/297 (47%), Positives = 197/297 (66%), Gaps = 15/297 (5%)
Query: 6 DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64
DLS R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + Q+ ++
Sbjct: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINML 73
Query: 65 MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116
K H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+
Sbjct: 74 KKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYI 133
Query: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
RE L+GL +LH +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPY
Sbjct: 134 CREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
Query: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234
WMAPEV A + Y+ DLW++GITAIE+AE PP+ D+HPMRALFL+ ++ P
Sbjct: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAP 251
Query: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN 290
+LK K KWS F F++ L KN +RP E+L++HPF+ Q R + I+L D ++
Sbjct: 252 RLKSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHID 307
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 266 bits (679), Expect = 8e-71
Identities = 141/297 (47%), Positives = 197/297 (66%), Gaps = 15/297 (5%)
Query: 6 DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64
DLS R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + Q+ ++
Sbjct: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINML 73
Query: 65 MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116
K H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+
Sbjct: 74 KKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYI 133
Query: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
RE L+GL +LH +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPY
Sbjct: 134 CREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
Query: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234
WMAPEV A + Y+ DLW++GITAIE+AE PP+ D+HPMRALFL+ ++ P
Sbjct: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAP 251
Query: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN 290
+LK K KWS F F++ L KN +RP E+L++HPF+ Q R + I+L D ++
Sbjct: 252 RLKSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHID 307
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 266 bits (679), Expect = 8e-71
Identities = 141/297 (47%), Positives = 197/297 (66%), Gaps = 15/297 (5%)
Query: 6 DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64
DLS R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + Q+ ++
Sbjct: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINML 73
Query: 65 MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116
K H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+
Sbjct: 74 KKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYI 133
Query: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
RE L+GL +LH +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPY
Sbjct: 134 CREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
Query: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234
WMAPEV A + Y+ DLW++GITAIE+AE PP+ D+HPMRALFL+ ++ P
Sbjct: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAP 251
Query: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN 290
+LK K KWS F F++ L KN +RP E+L++HPF+ Q R + I+L D ++
Sbjct: 252 RLKSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHID 307
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 262 bits (669), Expect = 1e-69
Identities = 140/309 (45%), Positives = 199/309 (64%), Gaps = 13/309 (4%)
Query: 3 PGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGED-FAVVQQE 61
PG + +P+E F +++IG G++G+V+K + T ++ AIK+I LE ED +QQE
Sbjct: 11 PGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQE 70
Query: 62 IIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETL 121
I ++ C P + Y+GSYL+ KLWI ME+ GGGS D+ GPL E QIA + RE L
Sbjct: 71 ITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE-PGPLDETQIATILREIL 129
Query: 122 QGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPE 181
+GL YLHS+ K+HRDIK AN+LL+++G VKLADFGV+ Q+T T KR +F+GTP+WMAPE
Sbjct: 130 KGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 189
Query: 182 VAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMK 241
V ++ Y+ D+W++GITAIELA +PP +LHPM+ LFL+ K+N PP L+
Sbjct: 190 VI---KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNN--PPTLEG--N 242
Query: 242 WSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTR-SLAIELLDKVNNPDHSTYHD- 299
+S FV+ L K P RPTA++LL+H F+ ++ + S EL+D+ HD
Sbjct: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDD 302
Query: 300 --FDDDDPE 306
+D D E
Sbjct: 303 SSSEDSDAE 311
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 262 bits (669), Expect = 1e-69
Identities = 156/378 (41%), Positives = 223/378 (58%), Gaps = 39/378 (10%)
Query: 6 DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64
DLS R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + Q+ ++
Sbjct: 14 DLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINML 73
Query: 65 MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116
K H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+
Sbjct: 74 KKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYI 133
Query: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
RE L+GL +LH+ +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPY
Sbjct: 134 CREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
Query: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234
WMAPEV A + Y+ D+W++GITAIE+AE PP+ D+HPMRALFL+ ++ PP
Sbjct: 194 WMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPP 251
Query: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLT-RSLAIELLDKVNNP- 292
+LK K KWS F F+ L K RP E+LL+ PF+ T R + I+L D ++
Sbjct: 252 RLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSR 310
Query: 293 -----------DHSTYHDFDDD-----DPEPLVAVPHRIHSTSRN-----VREEKTRSEI 331
++S + DD +P ++ VP ST R +E K+ SE
Sbjct: 311 KKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPG--ESTLRREFLRLQQENKSNSEA 368
Query: 332 TFGQVKFDPPLRKETEPH 349
Q + +++ E H
Sbjct: 369 LKQQQQLQQQQQRDPEAH 386
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 262 bits (669), Expect = 1e-69
Identities = 156/378 (41%), Positives = 223/378 (58%), Gaps = 39/378 (10%)
Query: 6 DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64
DLS R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + Q+ ++
Sbjct: 14 DLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINML 73
Query: 65 MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116
K H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+
Sbjct: 74 KKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYI 133
Query: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
RE L+GL +LH+ +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPY
Sbjct: 134 CREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
Query: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234
WMAPEV A + Y+ D+W++GITAIE+AE PP+ D+HPMRALFL+ ++ PP
Sbjct: 194 WMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPP 251
Query: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLT-RSLAIELLDKVNNP- 292
+LK K KWS F F+ L K RP E+LL+ PF+ T R + I+L D ++
Sbjct: 252 RLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSR 310
Query: 293 -----------DHSTYHDFDDD-----DPEPLVAVPHRIHSTSRN-----VREEKTRSEI 331
++S + DD +P ++ VP ST R +E K+ SE
Sbjct: 311 KKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPG--ESTLRREFLRLQQENKSNSEA 368
Query: 332 TFGQVKFDPPLRKETEPH 349
Q + +++ E H
Sbjct: 369 LKQQQQLQQQQQRDPEAH 386
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 262 bits (669), Expect = 1e-69
Identities = 156/378 (41%), Positives = 223/378 (58%), Gaps = 39/378 (10%)
Query: 6 DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64
DLS R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + Q+ ++
Sbjct: 14 DLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINML 73
Query: 65 MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116
K H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+
Sbjct: 74 KKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYI 133
Query: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
RE L+GL +LH+ +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPY
Sbjct: 134 CREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
Query: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234
WMAPEV A + Y+ D+W++GITAIE+AE PP+ D+HPMRALFL+ ++ PP
Sbjct: 194 WMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPP 251
Query: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLT-RSLAIELLDKVNNP- 292
+LK K KWS F F+ L K RP E+LL+ PF+ T R + I+L D ++
Sbjct: 252 RLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSR 310
Query: 293 -----------DHSTYHDFDDD-----DPEPLVAVPHRIHSTSRN-----VREEKTRSEI 331
++S + DD +P ++ VP ST R +E K+ SE
Sbjct: 311 KKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPG--ESTLRREFLRLQQENKSNSEA 368
Query: 332 TFGQVKFDPPLRKETEPH 349
Q + +++ E H
Sbjct: 369 LKQQQQLQQQQQRDPEAH 386
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 262 bits (669), Expect = 1e-69
Identities = 156/378 (41%), Positives = 223/378 (58%), Gaps = 39/378 (10%)
Query: 6 DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64
DLS R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + Q+ ++
Sbjct: 14 DLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINML 73
Query: 65 MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116
K H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+
Sbjct: 74 KKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYI 133
Query: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
RE L+GL +LH+ +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPY
Sbjct: 134 CREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
Query: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234
WMAPEV A + Y+ D+W++GITAIE+AE PP+ D+HPMRALFL+ ++ PP
Sbjct: 194 WMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPP 251
Query: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLT-RSLAIELLDKVNNP- 292
+LK K KWS F F+ L K RP E+LL+ PF+ T R + I+L D ++
Sbjct: 252 RLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSR 310
Query: 293 -----------DHSTYHDFDDD-----DPEPLVAVPHRIHSTSRN-----VREEKTRSEI 331
++S + DD +P ++ VP ST R +E K+ SE
Sbjct: 311 KKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPG--ESTLRREFLRLQQENKSNSEA 368
Query: 332 TFGQVKFDPPLRKETEPH 349
Q + +++ E H
Sbjct: 369 LKQQQQLQQQQQRDPEAH 386
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 261 bits (668), Expect = 2e-69
Identities = 149/344 (43%), Positives = 213/344 (61%), Gaps = 19/344 (5%)
Query: 3 PGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGED-FAVVQQE 61
PG + +P+E F ++RIG G++G+V+K + T ++ AIK+I LE ED +QQE
Sbjct: 11 PGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQE 70
Query: 62 IIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETL 121
I ++ C + Y+GSYL+ KLWI ME+ GGGS D+ GP E QIA + +E L
Sbjct: 71 ITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEIL 129
Query: 122 QGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPE 181
+GL YLHS+ K+HRDIK AN+LL++ G VKLADFGV+ Q+T T KR +F+GTP+WMAPE
Sbjct: 130 KGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 189
Query: 182 VAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMK 241
V ++ Y+ D+W++GITAIELA+ +PP D+HPMR LFL+ K+N PP L
Sbjct: 190 VI---QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNN--PPTLVG--D 242
Query: 242 WSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTR-SLAIELLDKVNNPDHSTYHDF 300
++ SF F+ L K+P RPTA++LL+H F+ ++ + S EL+D+ + D
Sbjct: 243 FTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSD- 301
Query: 301 DDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRK 344
D+ D E + STS RE T E +F V+ P +K
Sbjct: 302 DESDSEGSDS-----ESTS---RENNTHPEWSFTTVRKKPDPKK 337
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 259 bits (661), Expect = 1e-68
Identities = 138/303 (45%), Positives = 197/303 (65%), Gaps = 13/303 (4%)
Query: 9 RRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGED-FAVVQQEIIMMKD 67
+ +P+E F +++IG G++G+V+K + T ++ AIK+I LE ED +QQEI ++
Sbjct: 29 KADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQ 88
Query: 68 CKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYL 127
C P + Y+GSYL+ KLWI ME+ GGGS D+ GPL E QIA + RE L+GL YL
Sbjct: 89 CDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE-PGPLDETQIATILREILKGLDYL 147
Query: 128 HSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVER 187
HS+ K+HRDIK AN+LL+++G VKLADFGV+ Q+T T KR +F+GTP+WMAPEV +
Sbjct: 148 HSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---K 204
Query: 188 KGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFH 247
+ Y+ D+W++GITAIELA +PP +LHPM+ LFL+ K+N PP L+ +S
Sbjct: 205 QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNN--PPTLEG--NYSKPLK 260
Query: 248 HFVKMALTKNPKKRPTAEKLLQHPFVTQHLTR-SLAIELLDKVNNPDHSTYHD---FDDD 303
FV+ L K P RPTA++LL+H F+ ++ + S EL+D+ HD +D
Sbjct: 261 EFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDS 320
Query: 304 DPE 306
D E
Sbjct: 321 DAE 323
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 256 bits (654), Expect = 7e-68
Identities = 128/282 (45%), Positives = 187/282 (66%), Gaps = 8/282 (2%)
Query: 6 DLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMM 65
D + P+E F++++++G G+YG V+KA + +G++ AIK + +E D + +EI +M
Sbjct: 17 DSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE--SDLQEIIKEISIM 74
Query: 66 KDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGP-LSELQIAYVSRETLQGL 124
+ C P +V Y+GSY + LWI ME+CG GS+ DI + L E +IA + + TL+GL
Sbjct: 75 QQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGL 134
Query: 125 YYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAA 184
YLH K+HRDIK NILL GH KLADFGV+ Q+T T+AKR + IGTP+WMAPEV
Sbjct: 135 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI- 193
Query: 185 VERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSN 244
++ GYN + D+W++GIT+IE+AE +PP D+HPMRA+F++ + PP + WS+
Sbjct: 194 --QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPELWSD 249
Query: 245 SFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELL 286
F FVK L KNP++R TA +LLQHPF+ S+ +L+
Sbjct: 250 DFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLI 291
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 244 bits (623), Expect = 3e-64
Identities = 136/337 (40%), Positives = 196/337 (58%), Gaps = 10/337 (2%)
Query: 11 NPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKH 70
+P E +E++ +G G +G VYKA+N TG LAA KVI+ + E+ EI ++ C H
Sbjct: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH 90
Query: 71 PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIY-HVTGPLSELQIAYVSRETLQGLYYLHS 129
P IV G+Y KLWI +EFC GG++ I + L+E QI V R+ L+ L +LHS
Sbjct: 91 PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHS 150
Query: 130 KGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE--R 187
K +HRD+K N+L+T G ++LADFGVSA+ T+ KR SFIGTPYWMAPEV E +
Sbjct: 151 KRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMK 210
Query: 188 KGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFH 247
Y+ D+W++GIT IE+A+++PP +L+PMR L + KS+ PP L KWS F
Sbjct: 211 DTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSD--PPTLLTPSKWSVEFR 268
Query: 248 HFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEP 307
F+K+AL KNP+ RP+A +LL+HPFV+ + EL+ + D D+ E
Sbjct: 269 DFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEE- 327
Query: 308 LVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRK 344
+ + S + SE++ + D PL +
Sbjct: 328 ----EDAVDAASTLENHTQNSSEVSPPSLNADKPLEE 360
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 240 bits (612), Expect = 5e-63
Identities = 130/308 (42%), Positives = 183/308 (59%), Gaps = 8/308 (2%)
Query: 11 NPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKH 70
NP++ +E+I +G G +G VYKA+N T LAA KVI + E+ EI ++ C H
Sbjct: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDH 88
Query: 71 PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIY-HVTGPLSELQIAYVSRETLQGLYYLHS 129
PNIV ++ + LWI +EFC GG++ + + PL+E QI V ++TL L YLH
Sbjct: 89 PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD 148
Query: 130 KGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE--R 187
+HRD+K NIL T +G +KLADFGVSA+ T TI +R SFIGTPYWMAPEV E +
Sbjct: 149 NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSK 208
Query: 188 KGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFH 247
Y+ D+W++GIT IE+AE++PP +L+PMR L + KS +PP L +WS++F
Sbjct: 209 DRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKS--EPPTLAQPSRWSSNFK 266
Query: 248 HFVKMALTKNPKKRPTAEKLLQHPFVT---QHLTRSLAIELLDKVNNPDHSTYHDFDDDD 304
F+K L KN R T +LLQHPFVT R L E +V + ++++
Sbjct: 267 DFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEE 326
Query: 305 PEPLVAVP 312
E + +P
Sbjct: 327 TENSLPIP 334
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 239 bits (609), Expect = 1e-62
Identities = 126/278 (45%), Positives = 176/278 (63%), Gaps = 17/278 (6%)
Query: 11 NPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKH 70
+P + +E+ + IG GTYG V+K N G+ AA+K++ D + + I+ H
Sbjct: 16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDH 75
Query: 71 PNIVAYFGSYLRRDK-----LWICMEFCGGGSLQDIYHVTGPL------SELQIAYVSRE 119
PN+V ++G Y ++DK LW+ +E C GGS+ D+ V G L SE IAY+ E
Sbjct: 76 PNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDL--VKGFLKRGERMSEPLIAYILHE 133
Query: 120 TLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMA 179
L GL +LH+ +HRD+KG NILLT G VKL DFGVSAQ+T+T +R + +GTP+WMA
Sbjct: 134 ALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMA 193
Query: 180 PEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLK 237
PEV A E++ Y+ CD W++GITAIEL + PP+ DLHPMRALF + ++ PPKL+
Sbjct: 194 PEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRN--PPPKLR 251
Query: 238 DKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQ 275
WS F+ F+ LTK+ +KRPT +LLQH F+TQ
Sbjct: 252 QPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQ 289
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,256,196
Number of Sequences: 37866
Number of extensions: 2021365
Number of successful extensions: 16935
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 740
Number of HSP's successfully gapped in prelim test: 406
Number of HSP's that attempted gapping in prelim test: 11393
Number of HSP's gapped (non-prelim): 3438
length of query: 894
length of database: 18,247,518
effective HSP length: 111
effective length of query: 783
effective length of database: 14,044,392
effective search space: 10996758936
effective search space used: 10996758936
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.