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Search of human proteins with 154354966
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154354966 inner membrane protein, mitochondrial isoform 3
[Homo sapiens]
(747 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154354966 inner membrane protein, mitochondrial isoform 3 [Ho... 1439 0.0
gi|154354964 inner membrane protein, mitochondrial isoform 1 [Ho... 1430 0.0
gi|154354962 inner membrane protein, mitochondrial isoform 2 [Ho... 1424 0.0
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 73 1e-12
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 73 1e-12
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 73 1e-12
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 70 5e-12
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 62 1e-09
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 62 3e-09
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 61 4e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 60 6e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 60 6e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 60 6e-09
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 60 6e-09
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 60 6e-09
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 60 6e-09
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 60 6e-09
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 60 6e-09
gi|42794779 myosin 18A isoform b [Homo sapiens] 60 1e-08
gi|28416946 myosin 18A isoform a [Homo sapiens] 60 1e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 59 1e-08
gi|55770834 centromere protein F [Homo sapiens] 59 2e-08
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 59 2e-08
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 58 3e-08
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 58 4e-08
gi|38044112 restin isoform b [Homo sapiens] 57 5e-08
gi|4506751 restin isoform a [Homo sapiens] 57 5e-08
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 57 6e-08
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 57 8e-08
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 57 8e-08
>gi|154354966 inner membrane protein, mitochondrial isoform 3 [Homo
sapiens]
Length = 747
Score = 1439 bits (3724), Expect = 0.0
Identities = 747/747 (100%), Positives = 747/747 (100%)
Query: 1 MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG 60
MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG
Sbjct: 1 MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG 60
Query: 61 TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE 120
TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE
Sbjct: 61 TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE 120
Query: 121 SKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALSEEASS 180
SKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALSEEASS
Sbjct: 121 SKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALSEEASS 180
Query: 181 SSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNA 240
SSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNA
Sbjct: 181 SSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNA 240
Query: 241 HSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN 300
HSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN
Sbjct: 241 HSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN 300
Query: 301 AKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKR 360
AKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKR
Sbjct: 301 AKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKR 360
Query: 361 ELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHIT 420
ELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHIT
Sbjct: 361 ELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHIT 420
Query: 421 LALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHT 480
LALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHT
Sbjct: 421 LALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHT 480
Query: 481 DHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQ 540
DHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQ
Sbjct: 481 DHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQ 540
Query: 541 AVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQA 600
AVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQA
Sbjct: 541 AVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQA 600
Query: 601 LTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPP 660
LTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPP
Sbjct: 601 LTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPP 660
Query: 661 QQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMT 720
QQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMT
Sbjct: 661 QQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMT 720
Query: 721 LETKQIVEILTAYASAVGIGTTQVQPE 747
LETKQIVEILTAYASAVGIGTTQVQPE
Sbjct: 721 LETKQIVEILTAYASAVGIGTTQVQPE 747
>gi|154354964 inner membrane protein, mitochondrial isoform 1 [Homo
sapiens]
Length = 758
Score = 1430 bits (3702), Expect = 0.0
Identities = 747/758 (98%), Positives = 747/758 (98%), Gaps = 11/758 (1%)
Query: 1 MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG 60
MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG
Sbjct: 1 MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG 60
Query: 61 TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE 120
TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE
Sbjct: 61 TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE 120
Query: 121 SKQPASQLQKQKGDTPASATA-----------GDTLSVPAPAVQPEESLKTDHPEIGEGK 169
SKQPASQLQKQKGDTPASATA GDTLSVPAPAVQPEESLKTDHPEIGEGK
Sbjct: 121 SKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGK 180
Query: 170 PTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA 229
PTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA
Sbjct: 181 PTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA 240
Query: 230 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 289
AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE
Sbjct: 241 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 300
Query: 290 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE 349
ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE
Sbjct: 301 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE 360
Query: 350 LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA 409
LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA
Sbjct: 361 LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA 420
Query: 410 EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR 469
EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR
Sbjct: 421 EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR 480
Query: 470 TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN 529
TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN
Sbjct: 481 TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN 540
Query: 530 TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK 589
TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK
Sbjct: 541 TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK 600
Query: 590 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL 649
ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL
Sbjct: 601 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL 660
Query: 650 SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV 709
SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV
Sbjct: 661 SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV 720
Query: 710 AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE 747
AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE
Sbjct: 721 AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE 758
>gi|154354962 inner membrane protein, mitochondrial isoform 2 [Homo
sapiens]
Length = 757
Score = 1424 bits (3685), Expect = 0.0
Identities = 746/758 (98%), Positives = 746/758 (98%), Gaps = 12/758 (1%)
Query: 1 MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG 60
MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG
Sbjct: 1 MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG 60
Query: 61 TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE 120
TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE
Sbjct: 61 TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE 120
Query: 121 SKQPASQLQKQKGDTPASATA-----------GDTLSVPAPAVQPEESLKTDHPEIGEGK 169
SKQPASQLQKQKGDTPASATA GDTLSVPAPAVQPEESLKTDHPEIGEGK
Sbjct: 121 SKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGK 180
Query: 170 PTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA 229
PTPALSE ASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA
Sbjct: 181 PTPALSE-ASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA 239
Query: 230 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 289
AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE
Sbjct: 240 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 299
Query: 290 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE 349
ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE
Sbjct: 300 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE 359
Query: 350 LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA 409
LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA
Sbjct: 360 LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA 419
Query: 410 EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR 469
EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR
Sbjct: 420 EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR 479
Query: 470 TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN 529
TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN
Sbjct: 480 TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN 539
Query: 530 TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK 589
TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK
Sbjct: 540 TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK 599
Query: 590 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL 649
ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL
Sbjct: 600 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL 659
Query: 650 SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV 709
SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV
Sbjct: 660 SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV 719
Query: 710 AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE 747
AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE
Sbjct: 720 AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE 757
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 72.8 bits (177), Expect = 1e-12
Identities = 117/497 (23%), Positives = 204/497 (41%), Gaps = 66/497 (13%)
Query: 102 KSIQSGPLKISSVSEVMKESKQPASQLQKQKGDT--PASATAGDTLSVPAPAVQPEESLK 159
KS++ ++ E ++ + ++ +KQ+ D A G+ +E
Sbjct: 1136 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1195
Query: 160 TDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQ 219
E+ E K T L EE + I E +E+ R Q + LA+ LE A R
Sbjct: 1196 KREQEVTELKKT--LEEE---TRIHEAAVQELRQRHGQA-------LGELAEQLEQARRG 1243
Query: 220 TASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 279
+ +A + A V + A + L+ A E + Q + V+G + +A E
Sbjct: 1244 KGAWEKTRLALE-AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAE 1302
Query: 280 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK------- 332
AA+ L +A+ ELE + + A+ K + +K +++ E +LH+ L +
Sbjct: 1303 AAEKLQRAQAELENVSGALNEAESKTIRLSK-ELSSTEAQLHDAQELLQEETRAKLALGS 1361
Query: 333 KVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNS 392
+V+A ++EA + + E AR+ REL + + L W+ + + ++
Sbjct: 1362 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQ-LSEWRRRQEEEAGALEAGEEAR- 1419
Query: 393 LIAHAHRRIDQLNRELAEQKAT-------------EKQHITLALEKQK-----LEEK-RA 433
A R + L + LAE+ T E T+ LE+Q+ LE+K R
Sbjct: 1420 --RRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRK 1477
Query: 434 FDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 493
FD +A E + ++A ++R+ E + E E R +A R+ L Q +
Sbjct: 1478 FDQLLA---EEKAAVLRAVEERERAEA-EGREREARALSLTRALEEEQEAREELERQNRA 1533
Query: 494 LKSEFEQNLSEK----LSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAE 549
L++E E LS K S EL+ EQ N LR ++ A
Sbjct: 1534 LRAELEALLSSKDDVGKSVHELERACRVAEQAAN----------DLRAQVTELEDELTAA 1583
Query: 550 EEARKAHQLWLSVEALK 566
E+A+ +L ++V+ALK
Sbjct: 1584 EDAKL--RLEVTVQALK 1598
Score = 40.0 bits (92), Expect = 0.008
Identities = 79/392 (20%), Positives = 155/392 (39%), Gaps = 57/392 (14%)
Query: 189 EEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAA 248
EE RLA ++++ ++ + L + + + + + Q +Q + AH + A
Sbjct: 932 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH-IQELEAHLEAEEGA 990
Query: 249 MDNSEIAGEKKSAQWRTVEGAL-----------KERRKAVDEAADALLKAKEELEKMKSV 297
++ A+ + E L KER+ D A+ +A EE EK+KS+
Sbjct: 991 RQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSL 1050
Query: 298 IENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDD 357
+ K E I D+++ ++K + + E +
Sbjct: 1051 NKLRLKYEAT----------------IADMEDRLRKEEKGRQEL--------------EK 1080
Query: 358 FKRELDSITPEVLPGW--KGMSVSDLADKL--STDDLNSLIAHAHRRIDQLNRELAEQKA 413
KR LD + E+ + +L +L ++L + +A A D+ K+
Sbjct: 1081 LKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE---DEGGARAQLLKS 1137
Query: 414 TEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDA--MENEMRTQ 471
+ LA ++ LE +R + K E++A + ++E+ D+ + E+R++
Sbjct: 1138 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRG-ELEDTLDSTNAQQELRSK 1196
Query: 472 LRRQAAAHTDHLRDVLRVQE---QELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDI 528
++ L + R+ E QEL+ Q L E L+EQ Q RR + + L +
Sbjct: 1197 REQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE-LAEQLEQARR-GKGAWEKTRLAL 1254
Query: 529 NTAYARLRGIEQAVQSHAVAEEEARKAHQLWL 560
+ LR ++Q+ E+ R+ +L L
Sbjct: 1255 EAEVSELRAELSSLQTARQEGEQRRRRLELQL 1286
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 72.8 bits (177), Expect = 1e-12
Identities = 117/497 (23%), Positives = 204/497 (41%), Gaps = 66/497 (13%)
Query: 102 KSIQSGPLKISSVSEVMKESKQPASQLQKQKGDT--PASATAGDTLSVPAPAVQPEESLK 159
KS++ ++ E ++ + ++ +KQ+ D A G+ +E
Sbjct: 1128 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1187
Query: 160 TDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQ 219
E+ E K T L EE + I E +E+ R Q + LA+ LE A R
Sbjct: 1188 KREQEVTELKKT--LEEE---TRIHEAAVQELRQRHGQA-------LGELAEQLEQARRG 1235
Query: 220 TASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 279
+ +A + A V + A + L+ A E + Q + V+G + +A E
Sbjct: 1236 KGAWEKTRLALE-AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAE 1294
Query: 280 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK------- 332
AA+ L +A+ ELE + + A+ K + +K +++ E +LH+ L +
Sbjct: 1295 AAEKLQRAQAELENVSGALNEAESKTIRLSK-ELSSTEAQLHDAQELLQEETRAKLALGS 1353
Query: 333 KVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNS 392
+V+A ++EA + + E AR+ REL + + L W+ + + ++
Sbjct: 1354 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQ-LSEWRRRQEEEAGALEAGEEAR- 1411
Query: 393 LIAHAHRRIDQLNRELAEQKAT-------------EKQHITLALEKQK-----LEEK-RA 433
A R + L + LAE+ T E T+ LE+Q+ LE+K R
Sbjct: 1412 --RRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRK 1469
Query: 434 FDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 493
FD +A E + ++A ++R+ E + E E R +A R+ L Q +
Sbjct: 1470 FDQLLA---EEKAAVLRAVEERERAEA-EGREREARALSLTRALEEEQEAREELERQNRA 1525
Query: 494 LKSEFEQNLSEK----LSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAE 549
L++E E LS K S EL+ EQ N LR ++ A
Sbjct: 1526 LRAELEALLSSKDDVGKSVHELERACRVAEQAAN----------DLRAQVTELEDELTAA 1575
Query: 550 EEARKAHQLWLSVEALK 566
E+A+ +L ++V+ALK
Sbjct: 1576 EDAKL--RLEVTVQALK 1590
Score = 40.0 bits (92), Expect = 0.008
Identities = 79/392 (20%), Positives = 155/392 (39%), Gaps = 57/392 (14%)
Query: 189 EEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAA 248
EE RLA ++++ ++ + L + + + + + Q +Q + AH + A
Sbjct: 924 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH-IQELEAHLEAEEGA 982
Query: 249 MDNSEIAGEKKSAQWRTVEGAL-----------KERRKAVDEAADALLKAKEELEKMKSV 297
++ A+ + E L KER+ D A+ +A EE EK+KS+
Sbjct: 983 RQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSL 1042
Query: 298 IENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDD 357
+ K E I D+++ ++K + + E +
Sbjct: 1043 NKLRLKYEAT----------------IADMEDRLRKEEKGRQEL--------------EK 1072
Query: 358 FKRELDSITPEVLPGW--KGMSVSDLADKL--STDDLNSLIAHAHRRIDQLNRELAEQKA 413
KR LD + E+ + +L +L ++L + +A A D+ K+
Sbjct: 1073 LKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE---DEGGARAQLLKS 1129
Query: 414 TEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDA--MENEMRTQ 471
+ LA ++ LE +R + K E++A + ++E+ D+ + E+R++
Sbjct: 1130 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRG-ELEDTLDSTNAQQELRSK 1188
Query: 472 LRRQAAAHTDHLRDVLRVQE---QELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDI 528
++ L + R+ E QEL+ Q L E L+EQ Q RR + + L +
Sbjct: 1189 REQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE-LAEQLEQARR-GKGAWEKTRLAL 1246
Query: 529 NTAYARLRGIEQAVQSHAVAEEEARKAHQLWL 560
+ LR ++Q+ E+ R+ +L L
Sbjct: 1247 EAEVSELRAELSSLQTARQEGEQRRRRLELQL 1278
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 72.8 bits (177), Expect = 1e-12
Identities = 117/497 (23%), Positives = 204/497 (41%), Gaps = 66/497 (13%)
Query: 102 KSIQSGPLKISSVSEVMKESKQPASQLQKQKGDT--PASATAGDTLSVPAPAVQPEESLK 159
KS++ ++ E ++ + ++ +KQ+ D A G+ +E
Sbjct: 1169 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1228
Query: 160 TDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQ 219
E+ E K T L EE + I E +E+ R Q + LA+ LE A R
Sbjct: 1229 KREQEVTELKKT--LEEE---TRIHEAAVQELRQRHGQA-------LGELAEQLEQARRG 1276
Query: 220 TASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 279
+ +A + A V + A + L+ A E + Q + V+G + +A E
Sbjct: 1277 KGAWEKTRLALE-AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAE 1335
Query: 280 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK------- 332
AA+ L +A+ ELE + + A+ K + +K +++ E +LH+ L +
Sbjct: 1336 AAEKLQRAQAELENVSGALNEAESKTIRLSK-ELSSTEAQLHDAQELLQEETRAKLALGS 1394
Query: 333 KVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNS 392
+V+A ++EA + + E AR+ REL + + L W+ + + ++
Sbjct: 1395 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQ-LSEWRRRQEEEAGALEAGEEAR- 1452
Query: 393 LIAHAHRRIDQLNRELAEQKAT-------------EKQHITLALEKQK-----LEEK-RA 433
A R + L + LAE+ T E T+ LE+Q+ LE+K R
Sbjct: 1453 --RRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRK 1510
Query: 434 FDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 493
FD +A E + ++A ++R+ E + E E R +A R+ L Q +
Sbjct: 1511 FDQLLA---EEKAAVLRAVEERERAEA-EGREREARALSLTRALEEEQEAREELERQNRA 1566
Query: 494 LKSEFEQNLSEK----LSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAE 549
L++E E LS K S EL+ EQ N LR ++ A
Sbjct: 1567 LRAELEALLSSKDDVGKSVHELERACRVAEQAAN----------DLRAQVTELEDELTAA 1616
Query: 550 EEARKAHQLWLSVEALK 566
E+A+ +L ++V+ALK
Sbjct: 1617 EDAKL--RLEVTVQALK 1631
Score = 40.0 bits (92), Expect = 0.008
Identities = 79/392 (20%), Positives = 155/392 (39%), Gaps = 57/392 (14%)
Query: 189 EEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAA 248
EE RLA ++++ ++ + L + + + + + Q +Q + AH + A
Sbjct: 965 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH-IQELEAHLEAEEGA 1023
Query: 249 MDNSEIAGEKKSAQWRTVEGAL-----------KERRKAVDEAADALLKAKEELEKMKSV 297
++ A+ + E L KER+ D A+ +A EE EK+KS+
Sbjct: 1024 RQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSL 1083
Query: 298 IENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDD 357
+ K E I D+++ ++K + + E +
Sbjct: 1084 NKLRLKYEAT----------------IADMEDRLRKEEKGRQEL--------------EK 1113
Query: 358 FKRELDSITPEVLPGW--KGMSVSDLADKL--STDDLNSLIAHAHRRIDQLNRELAEQKA 413
KR LD + E+ + +L +L ++L + +A A D+ K+
Sbjct: 1114 LKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE---DEGGARAQLLKS 1170
Query: 414 TEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDA--MENEMRTQ 471
+ LA ++ LE +R + K E++A + ++E+ D+ + E+R++
Sbjct: 1171 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRG-ELEDTLDSTNAQQELRSK 1229
Query: 472 LRRQAAAHTDHLRDVLRVQE---QELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDI 528
++ L + R+ E QEL+ Q L E L+EQ Q RR + + L +
Sbjct: 1230 REQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE-LAEQLEQARR-GKGAWEKTRLAL 1287
Query: 529 NTAYARLRGIEQAVQSHAVAEEEARKAHQLWL 560
+ LR ++Q+ E+ R+ +L L
Sbjct: 1288 EAEVSELRAELSSLQTARQEGEQRRRRLELQL 1319
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 70.5 bits (171), Expect = 5e-12
Identities = 134/607 (22%), Positives = 251/607 (41%), Gaps = 78/607 (12%)
Query: 151 AVQPEESLKTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVK-IESL 209
A Q +E+L+ P + + L E+ + S R+ E A++E Q QV+ +E
Sbjct: 811 AEQAQEALEQQLPTLRHERSQ--LQEQLAQLS-RQLSGREQELEQARREAQRQVEALERA 867
Query: 210 AKSLEDALRQTASVTLQAIAAQNAA--VQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVE 267
A+ E ++ A + +Q +AA+ + + K A++ S +++ AQ
Sbjct: 868 AREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ----- 922
Query: 268 GALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDL 327
L+ RR+ ++ ALL AKE L E+AG + I A + K +D
Sbjct: 923 --LEARREQLEAEGQALLLAKETL-----------TGELAGLRQQIIATQEKAS---LDK 966
Query: 328 DNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSV--SDLADKL 385
+ + +K+ A+ EA+ + + R + +L + E W+ + + L +L
Sbjct: 967 ELMAQKLVQAEREAQASLR------EQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQL 1020
Query: 386 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLA------------LEKQKLEEK-- 431
+ L+A ++L+ E+A + + + LA EK L EK
Sbjct: 1021 QREQ-EELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLM 1079
Query: 432 --RAFDSAVAKALEHHRSEIQA--EQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVL 487
R + ++ +E + + Q+ EQDR + ++R Q AAAH +R
Sbjct: 1080 GTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVR--- 1136
Query: 488 RVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQA--VQSH 545
R+QEQ +++ + +E+ RL ++ D ++ A +LR ++ VQ
Sbjct: 1137 RLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQ 1196
Query: 546 AVAE------EEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQ 599
E E A++ L S E L+ ++K + +E ++ L + + K + T
Sbjct: 1197 EAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEART- 1255
Query: 600 ALTAAIPPESLTRGVYSEETLRARFYA---VQKLARRVAMIDETRNSLYQYFLSYLQSLL 656
A+ E+ +E R+R A +Q+L R++ M+D L + L
Sbjct: 1256 ----AVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLA 1311
Query: 657 LFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESR---RVAQDW 713
L + + E + L AS + +L++A + + + +GE R R
Sbjct: 1312 LGERAEKESRRETL--GLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGS 1369
Query: 714 LKEARMT 720
L+EAR T
Sbjct: 1370 LEEARGT 1376
Score = 50.4 bits (119), Expect = 6e-06
Identities = 98/434 (22%), Positives = 172/434 (39%), Gaps = 68/434 (15%)
Query: 175 SEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAA 234
+E A S +R EE+ ARL ++++ +I +L + ++ L S QA++ + +
Sbjct: 1011 AERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESE 1070
Query: 235 VQAVNAH--SNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELE 292
A++ A + E+ +K+ AQ R++ +AL +L
Sbjct: 1071 KTALSEKLMGTRHSLATISLEMERQKRDAQ---------SRQEQDRSTVNALTSELRDLR 1121
Query: 293 KMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVV 352
+ A +EV +L DL K+ + EA+ + L+
Sbjct: 1122 AQREEAAAAHAQEVR-----------RLQEQARDLG---KQRDSCLREAEELRTQLRLLE 1167
Query: 353 QARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAE-- 410
ARD +REL ++ +G V + +L + + + L R E
Sbjct: 1168 DARDGLRRELLEAQRKLRESQEGREV----QRQEAGELRRSLGEGAKEREALRRSNEELR 1223
Query: 411 --QKATEKQHITLALEKQKLEEKRAF----DSAVAKALEHHRSEIQ------AEQDRKIE 458
K E + I+L L + E+K A +AV K R+ +Q E R+++
Sbjct: 1224 SAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQ 1283
Query: 459 EVRDAME--NEMRTQLRRQAA-----------AHTDHLRDVLRVQEQELKSEFEQNLSEK 505
E+R M+ + T+L R+ A A + R+ L ++++ LK E S +
Sbjct: 1284 ELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGE----ASLE 1339
Query: 506 LSEQELQF-RRLSQEQVDNFTLDINTAYARL---RGIEQAVQSHAVAEEEARKAHQLWLS 561
+ QELQ +R QEQ F L RG E+ HA E +A +
Sbjct: 1340 VMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAAR---- 1395
Query: 562 VEALKYSMKTSSAE 575
EA + ++ S+AE
Sbjct: 1396 AEAAELGLRLSAAE 1409
Score = 46.2 bits (108), Expect = 1e-04
Identities = 63/323 (19%), Positives = 137/323 (42%), Gaps = 39/323 (12%)
Query: 244 ILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKK 303
++ +A+ ++ + ++ + L RK + ++ +E+L++++ + A +
Sbjct: 523 LIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQ 582
Query: 304 KEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELD 363
A+ + + + N+ +Q AQ +A+ + Q E + A+++ +R+ D
Sbjct: 583 AH-EDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRD 641
Query: 364 SITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLAL 423
+ E + +V D A + + +HR+++QL E + LA
Sbjct: 642 RLEEE-----QEDAVQDGAR------VRRELERSHRQLEQL----------EGKRSVLAK 680
Query: 424 EKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHL 483
E ++ E + + L+ ++E+ AE K E R +E M T+LR + A+ D L
Sbjct: 681 ELVEVREALSRATLQRDMLQAEKAEV-AEALTKAEAGRVELELSM-TKLRAEEASLQDSL 738
Query: 484 RDVLRVQEQ---------ELKSEFEQNLS-----EKLSEQELQFRRLSQEQVDNFTLDIN 529
+ + E L ++ E+ S ++ +EQE R QE+++ L+
Sbjct: 739 SKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQE 798
Query: 530 TAYARLRG-IEQAVQSHAVAEEE 551
A L G + A Q+ E++
Sbjct: 799 VARQGLEGSLRVAEQAQEALEQQ 821
Score = 40.0 bits (92), Expect = 0.008
Identities = 76/407 (18%), Positives = 164/407 (40%), Gaps = 36/407 (8%)
Query: 101 KKSIQSGPLKISSVSEVMKESKQPASQLQ--KQKGDTPASATAGDTLSVPAPAVQPEESL 158
++S+Q+ ++ + E + + K ++L+ K++ A+ T+ + E L
Sbjct: 1606 ERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGEL 1665
Query: 159 KTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALR 218
+ + + + ++ S R+ EV A Q + + + E ALR
Sbjct: 1666 QRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR 1725
Query: 219 QTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVD 278
+A+A +A++ + + L+ A+ E + + AL E RK
Sbjct: 1726 DKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSS 1785
Query: 279 -----------EAADALLK---AKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMI 324
E AD L+ A+ +L++++ V+ ++ E A + + + +
Sbjct: 1786 SLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNT-VQKLQDERRLLQ 1844
Query: 325 VDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADK 384
L ++ + + ++E + V + + + R +R LD + E L + +V A+K
Sbjct: 1845 ERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHED-TVRLSAEK 1903
Query: 385 LSTD----DLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALE----------KQKLEE 430
D +A A R+I QL ++ E+ H LE +Q++E
Sbjct: 1904 GRLDRTLTGAELELAEAQRQIQQLEAQVV---VLEQSHSPAQLEVDAQQQQLELQQEVER 1960
Query: 431 KRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAA 477
R+ + + LE R ++ R +EE ++ +++ +LRR +A
Sbjct: 1961 LRSAQAQTERTLEA-RERAHRQRVRGLEEQVSTLKGQLQQELRRSSA 2006
Score = 36.6 bits (83), Expect = 0.087
Identities = 89/446 (19%), Positives = 181/446 (40%), Gaps = 87/446 (19%)
Query: 170 PTPALSEEASSSSIRE------------RPPEEVAARLAQQEKQEQVKIESLAKSLEDAL 217
P+PA S+ ++ + I R E + L +++ ES ++LE+ L
Sbjct: 511 PSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQL 570
Query: 218 RQTASVTLQAIAAQNAA---VQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERR 274
++ T A+ A A VQ + + + +L + + S +A + AQ + E L++ R
Sbjct: 571 QRLRDKTDGAMQAHEDAQREVQRLRSANELL--SREKSNLAHSLQVAQQQAEE--LRQER 626
Query: 275 KAVDEAADALLKAKEELEKMK--SVIENAK-KKEVAGAKPHITAAEGKLHNMIVDLDNVV 331
+ + A + L + ++ LE+ + +V + A+ ++E+ + + EGK + +L V
Sbjct: 627 EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVR 686
Query: 332 KKVQAA-------QSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMS-VSDLAD 383
+ + A Q+E V++ R + + + + E +S +S L +
Sbjct: 687 EALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNE 746
Query: 384 KLSTD--DLNSLIAHAHR------------------------RIDQLNRE---------- 407
L+ D DLN L+A R+++L E
Sbjct: 747 SLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEG 806
Query: 408 ---LAEQ--KATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRD 462
+AEQ +A E+Q TL E+ +L+E+ A S E + + E R++E +
Sbjct: 807 SLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALER 866
Query: 463 AMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVD 522
A R + A +H +++ E + + LSE+ + RL +E ++
Sbjct: 867 A--------AREKEALAKEHAGLAVQLVAAEREG---RTLSEEATR-----LRLEKEALE 910
Query: 523 NFTLDINTAYARLRGIEQAVQSHAVA 548
++ A+L + +++ A
Sbjct: 911 GSLFEVQRQLAQLEARREQLEAEGQA 936
Score = 32.3 bits (72), Expect = 1.6
Identities = 72/393 (18%), Positives = 158/393 (40%), Gaps = 72/393 (18%)
Query: 189 EEVAARLAQQEKQEQVKIESLAKSLEDALR---------QTASVTLQAIAAQNAAVQAVN 239
E++ A+ + + +K ++++ LE ALR + + Q++ + +
Sbjct: 94 EDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQA 153
Query: 240 AHSNILKAAMDNSEIAGEKKSAQW-RTVEGALKERRKAVDEAADALLKAKEELEKMKSVI 298
++ L+A + G+++ AQ + ++G + + +K E LL+ ELE+ + +
Sbjct: 154 SYRRKLQAYQE-----GQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQR--L 206
Query: 299 ENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDF 358
+ + + DL++ + +++ Q + ++Q + ++
Sbjct: 207 RDTEHSQ--------------------DLESALIRLEEEQQRSASLAQVNAML------- 239
Query: 359 KRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQH 418
+ +LD G ++S+ K++ D HR E + +H
Sbjct: 240 REQLDQA------GSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEH 293
Query: 419 ITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDA----------MENEM 468
L L +++ R S V E ++ E R V++A E+
Sbjct: 294 SRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRA 353
Query: 469 RTQLRRQA---AAHTDHLRD-VLR---VQEQELKSEFEQ-NLSEKLSEQELQFRRLSQEQ 520
L +QA A + LRD VLR + +Q+++S+ ++ +LS +++E L +RL ++
Sbjct: 354 EAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQN 413
Query: 521 V--DNFTLDINTAYARLRGIEQAVQSHAVAEEE 551
+ D D+ L + +Q A E E
Sbjct: 414 LEKDQVNKDLTEKLEALESLR--LQEQAALETE 444
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 62.4 bits (150), Expect = 1e-09
Identities = 108/481 (22%), Positives = 208/481 (43%), Gaps = 66/481 (13%)
Query: 129 QKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALSEEASSSSIRERPP 188
++Q PA+ G A + P + D E PTP +S E S+ PP
Sbjct: 526 REQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTE-PVAPP 584
Query: 189 EEV--AARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAH---SN 243
E++ AA A +E QV + LE +Q L+ Q + + H
Sbjct: 585 EQLSEAALKAMEEAVAQVLEQDQRHLLES--KQEKMQQLREKLCQEEEEEILRLHQQKEQ 642
Query: 244 ILKAAMDNSEIAGEKKSAQWRTVEGA----LKERRKAVDEAADALLKAKEE--LEKMKSV 297
L + + + A E++ A+ R E L+ + ++ +A + ++A++E L+K++
Sbjct: 643 SLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREE 702
Query: 298 IENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQ-SEAKVVSQYHELVVQARD 356
+E+ +K E A + E K M L+ + ++++A++ SE ++ E +Q
Sbjct: 703 LESQQKAERA-------SLEQKNRQM---LEQLKEEIEASEKSEQAALNAAKEKALQQ-- 750
Query: 357 DFKRELDSITPEVLPGWKGMSVSDLADKLST--DDLNSLIAHAHRR-IDQLNRELAEQKA 413
E L G + +V+ L + S + L S + HR + L +++ E +
Sbjct: 751 ---------LREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQ 801
Query: 414 TEKQHITLALEK------QKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENE 467
E+ + L + QK ++ ++ L R E++ E +R+++++++ +
Sbjct: 802 KEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQV 861
Query: 468 M-------RTQLRRQAAAHTDHLRDVL----RVQEQELKSEFEQNLSEKLSEQELQFRRL 516
M + R+Q A HL L R E+EL++ Q ++L ++L+ R
Sbjct: 862 MAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELET-VRQEQHKRL--EDLRRRHR 918
Query: 517 SQE-QVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVE---ALKYSMKTS 572
QE ++ + LD+ T R + ++ + V EE AR+ Q L V+ ALK T+
Sbjct: 919 EQERKLQDLELDLET---RAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATA 975
Query: 573 S 573
+
Sbjct: 976 T 976
Score = 46.2 bits (108), Expect = 1e-04
Identities = 93/427 (21%), Positives = 170/427 (39%), Gaps = 43/427 (10%)
Query: 121 SKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALS--EEA 178
++Q AS LQK + + + A + S+ Q E LK + E E AL+ +E
Sbjct: 690 AEQEAS-LQKLREELESQQKA-ERASLEQKNRQMLEQLK-EEIEASEKSEQAALNAAKEK 746
Query: 179 SSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAI--AAQNAAVQ 236
+ +RE+ E +A EK+ ++E L SLE R+ S + I A Q Q
Sbjct: 747 ALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQ 806
Query: 237 AVNAHSNILKAAMDNS-EIAGEKKSAQWRTVEGALKERRKAVD-EAADALLKAKEE---- 290
+ S +AG + + L+E+R+ V+ E L K KEE
Sbjct: 807 LQKCLGQVEHRVHQKSYHVAGYEHE-----LSSLLREKRQEVEGEHERRLDKMKEEHQQV 861
Query: 291 LEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEA-KVVSQYHE 349
+ K + E ++K+ A H+T G+L + + ++ V+ Q + + + + H
Sbjct: 862 MAKAREQYEAEERKQRAELLGHLT---GELERLQRAHERELETVRQEQHKRLEDLRRRHR 918
Query: 350 LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA 409
+ D + +L++ +V + V + + L + + ++
Sbjct: 919 EQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQ 978
Query: 410 EQKATEKQHITLALEKQKLEE--------KRAFDSAV------AKALEHHRSEIQAEQDR 455
+ + +K+H L Q+L E K +S V ++ L+ H S ++AE +
Sbjct: 979 QLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK 1038
Query: 456 KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRV-QEQELKSEFEQNLSEKLSEQELQFR 514
K +R+ E + H + LR L Q +E+ S Q S+++L
Sbjct: 1039 KQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQ------SKEDLYLD 1092
Query: 515 RLSQEQV 521
LS V
Sbjct: 1093 SLSSHNV 1099
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 61.6 bits (148), Expect = 3e-09
Identities = 99/487 (20%), Positives = 200/487 (41%), Gaps = 58/487 (11%)
Query: 109 LKISSVSEVMKESKQPASQLQKQKGDTPASATAGDTLS--VPAPAVQPEESLKTDHPEIG 166
L++S E M ++ ++++++ T +TL + A +Q +E L+ +
Sbjct: 838 LQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCA 897
Query: 167 EGKPTPA--------LSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALR 218
E + A L E R EE L ++K+ Q I+ L + LE+
Sbjct: 898 EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEES 957
Query: 219 QTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVD 278
+ L+ + + A ++ + IL+ N ++A EKK + R E + +
Sbjct: 958 ARQKLQLEKVTTE-AKLKKLEEEQIILED--QNCKLAKEKKLLEDRIAEFTTNLTEE--E 1012
Query: 279 EAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQ 338
E + +L K K + E M + +E ++E + + KL DL + + ++QA
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLEERLRREEK-QRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 339 SEAKV------------VSQYHELVVQARDDFK--RELDSITPEVLPGWKGMSVS-DLAD 383
+E K+ +++ E Q K REL+S E+ + S + A+
Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAE 1131
Query: 384 KLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALE 443
K D L A D L+ A+Q+ K+ + + K+ LEE+ A + +
Sbjct: 1132 KQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMR 1191
Query: 444 HHRSEI------QAEQDRKI----EEVRDAMENEM-----RTQLRRQAAAHTDHLRDVLR 488
S+ Q EQ +++ E+ + +ENE ++ Q ++H R +
Sbjct: 1192 QKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVE 1251
Query: 489 VQEQELKSEFEQ------NLSEKLSEQELQFRRL------SQEQVDNFTLDINTAYARLR 536
Q QEL+ +F + L++K+++ +++ + S + T D + ++L+
Sbjct: 1252 AQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQ 1311
Query: 537 GIEQAVQ 543
++ +Q
Sbjct: 1312 DTQELLQ 1318
Score = 58.5 bits (140), Expect = 2e-08
Identities = 106/509 (20%), Positives = 208/509 (40%), Gaps = 66/509 (12%)
Query: 174 LSEEASSSS--IRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQ 231
L+EE + S+ ER E AR +++ K SLA++LE+A+ Q A + +
Sbjct: 1450 LAEEKTISAKYAEERDRAEAEAR------EKETKALSLARALEEAMEQKAELERLNKQFR 1503
Query: 232 NAAVQAVNAHSNILKAA--MDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 289
+++ ++ K+ ++ S+ A E++ + +T L+E + DA L+ +
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKT---QLEELEDELQATEDAKLRLEV 1560
Query: 290 ELEKMKSVIE----------NAKKKEVA--------------GAKPHITAAEGKLHNMIV 325
L+ MK+ E KKK++ + AA KL +
Sbjct: 1561 NLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLK 1620
Query: 326 DLDNVVKKVQAAQSEAKVVSQYHELVVQAR------DDFKRELDSITPEVLPGWKGMSVS 379
DL+ + + EA + Q +L Q + DD + + I + K +
Sbjct: 1621 DLEAHIDSANKNRDEA--IKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSM 1678
Query: 380 DLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVA 439
+ A+ + + + A R+ Q ELA++ A LALE+++ E R + +
Sbjct: 1679 E-AEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARI--AQLE 1735
Query: 440 KALEHHRSEIQAEQDR------KIEEVRDAMENE-MRTQLRRQAAAHTDHLRDVLRVQEQ 492
+ LE + + DR +I+++ + E Q A + L+V+ Q
Sbjct: 1736 EELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQ 1795
Query: 493 ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAV-AEEE 551
E++ + ++ E + +L +EQ+DN T + A ++R E+ ++ + ++E
Sbjct: 1796 EMEGTVKSKYKASITALEAKIAQL-EEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE 1854
Query: 552 ARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQAL-TAAIPPESL 610
R A Q + +K + + EA +AN S + + L A +++
Sbjct: 1855 RRNAEQYKDQADKASTRLKQLKRQLEE----AEEEAQRANASRRKLQRELEDATETADAM 1910
Query: 611 TRGVYSEETLRAR----FYAVQKLARRVA 635
R V S + R F +++AR+ A
Sbjct: 1911 NREVSSLKNKLRRGDLPFVVPRRMARKGA 1939
Score = 51.6 bits (122), Expect = 3e-06
Identities = 82/389 (21%), Positives = 176/389 (45%), Gaps = 47/389 (12%)
Query: 174 LSEEASSSSIRERPPEEVAA--RLAQQEK-QEQVKIESLAKSLEDALRQTASVTLQAI-- 228
+++E +RE+ ++AA RL + E Q Q+ E L L++ L+ + +A
Sbjct: 848 MAKEEELVKVREK---QLAAENRLTEMETLQSQLMAEKL--QLQEQLQAETELCAEAEEL 902
Query: 229 -AAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKA 287
A A Q + + L+A ++ E + A+ + ++ ++E + ++E A K
Sbjct: 903 RARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL 962
Query: 288 KEELEKMKSVIENAKKKEVAGAKPHITAAEGK--LHNMIVDLD-NVVKKVQAAQSEAKVV 344
+ E ++ ++ +++++ + A+ K L + I + N+ ++ + ++S AK+
Sbjct: 963 QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLK 1022
Query: 345 SQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTD--DLNSLIAHAHRRID 402
+++ ++ + +RE + + KL D DL+ IA +I
Sbjct: 1023 NKHEAMITDLEERLRREEK----------QRQELEKTRRKLEGDSTDLSDQIAELQAQIA 1072
Query: 403 QLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRD 462
+L +LA+++ E+ LA ++EE+ A + K + E + +I E+++
Sbjct: 1073 ELKMQLAKKE--EELQAALA----RVEEEAAQKNMALKKIR--------ELESQISELQE 1118
Query: 463 AMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVD 522
+E+E + R +A L + L + LK+E E L ++QEL+ +R + +
Sbjct: 1119 DLESERAS--RNKAEKQKRDLGEEL----EALKTELEDTLDSTAAQQELRSKREQEVNIL 1172
Query: 523 NFTLDINTAYARLRGIEQAVQSHAVAEEE 551
TL+ A I++ Q H+ A EE
Sbjct: 1173 KKTLE-EEAKTHEAQIQEMRQKHSQAVEE 1200
Score = 45.4 bits (106), Expect = 2e-04
Identities = 74/335 (22%), Positives = 138/335 (41%), Gaps = 71/335 (21%)
Query: 116 EVMKESKQPASQLQ---KQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTP 172
E +K+ ++ +Q++ ++ DT AS + A A + E+ LK+ E+ + +
Sbjct: 1635 EAIKQLRKLQAQMKDCMRELDDTRASRE-----EILAQAKENEKKLKSMEAEMIQLQEEL 1689
Query: 173 ALSEEASSSSIRERPP--EEVA-----ARLAQQEKQE-QVKIESLAKSLEDALRQTASVT 224
A +E A + +ER +E+A LA +EK+ + +I L + LE+ T +
Sbjct: 1690 AAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIN 1749
Query: 225 LQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADAL 284
+ N + +N N+ ++ +E A ++ Q + +
Sbjct: 1750 -DRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKEL------------------ 1790
Query: 285 LKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVV 344
K +L++M+ +++ K ITA E K+ + LDN K+ QAA + +
Sbjct: 1791 ---KVKLQEMEGTVKSKYKAS-------ITALEAKIAQLEEQLDNETKERQAACKQVRRT 1840
Query: 345 SQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQL 404
+ + V+ DD +R + D ADK ST R+ QL
Sbjct: 1841 EKKLKDVLLQVDDERRNAE-------------QYKDQADKAST------------RLKQL 1875
Query: 405 NRELAEQKATEKQHITLALEKQKLEEKRAFDSAVA 439
R+L E+ E Q + K + E + A ++A A
Sbjct: 1876 KRQL-EEAEEEAQRANASRRKLQRELEDATETADA 1909
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 60.8 bits (146), Expect = 4e-09
Identities = 82/401 (20%), Positives = 172/401 (42%), Gaps = 57/401 (14%)
Query: 185 ERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAH--- 241
E EEV+ RL +Q + E L K +ED L + Q + + +NAH
Sbjct: 227 ENKKEEVS-RLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKL 285
Query: 242 SNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKM-KSVIEN 300
SN+ K+A D+SE + + + LKE +A D LL+ ++ ++M K ++E
Sbjct: 286 SNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEK 345
Query: 301 AKK--KEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVV------SQYHELVV 352
+ KE+ A ++A + K I+ + + A + AK+V ++ + V
Sbjct: 346 IGRLEKELENANDLLSATKRK--GAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYV 403
Query: 353 QARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQK 412
+ +D + + L +K L+ ++ + L R+ E +
Sbjct: 404 ETQDQ------------------LLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYE 445
Query: 413 ATEKQHITLALE-KQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE-EVRDAMENEMRT 470
+K +L+++ +Q ++E + KA + +S + +R++E +V+D + ++R
Sbjct: 446 RAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NKQSSVLERDNRRMEIQVKD-LSQQIRV 502
Query: 471 QLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTL---- 526
L A +H+ ++++E+ S + SE +S+ + +R + + Q N L
Sbjct: 503 LLMELEEARGNHV-----IRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVAL 557
Query: 527 ----------DINTAYARLRGIEQAVQSHAVAEEEARKAHQ 557
+ T +++ ++ ++S E+ RK+ Q
Sbjct: 558 RELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQ 598
Score = 53.5 bits (127), Expect = 7e-07
Identities = 86/399 (21%), Positives = 167/399 (41%), Gaps = 54/399 (13%)
Query: 184 RERPPEEVAA----RLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVN 239
RER +E + L + + ++E L KS + ++ S+ Q + Q
Sbjct: 564 REREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTG 623
Query: 240 AHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIE 299
+ +++D+ +A K T + V E+ +A+ +AK L++++ + E
Sbjct: 624 VAIPLHASSLDDVSLASTPKRPS--TSQTVSTPAPVPVIESTEAI-EAKAALKQLQEIFE 680
Query: 300 NAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFK 359
N KK++ K E KL + DL + K+ ++ S+ +E++ + ++
Sbjct: 681 NYKKEKAENEKIQNEQLE-KLQEQVTDLRSQNTKI---STQLDFASKRYEMLQDNVEGYR 736
Query: 360 RELDSITPEVLPGWKGMSVSDLADKLSTDDL---NSLIAHAHRRIDQLNRE--------- 407
RE+ S+ + T DL N +A A R + L +E
Sbjct: 737 REITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEV 796
Query: 408 ---------LAEQKA-----TEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQ 453
LAEQ+ T Q I LE+ + E K+ S + K LEH S ++ +
Sbjct: 797 RLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEK-LEHEISHLKKKL 855
Query: 454 DRKIEEVRDAMENEMRTQL---RRQAAAHTD-HL--RDVLRVQEQELKSEFEQNLSEKLS 507
+ ++E+ R + + QL +RQ T+ HL +++L+ ++E+ + L + LS
Sbjct: 856 ENEVEQ-RHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIAT-----LKQHLS 909
Query: 508 EQELQFRRLSQEQV----DNFTLDINTAYARLRGIEQAV 542
E+Q S ++ + D++ ++LR E+ V
Sbjct: 910 NMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQV 948
Score = 52.8 bits (125), Expect = 1e-06
Identities = 114/551 (20%), Positives = 212/551 (38%), Gaps = 76/551 (13%)
Query: 111 ISSVSEVMKESKQPASQLQKQ-KGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGK 169
++S+ E + + KQ +++K + SA L V+ E+ D
Sbjct: 969 VTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIES 1028
Query: 170 PTPALSEEASSSSIRERPPEEVAARL---------AQQEKQEQVKIESLAKSLEDALRQT 220
LSE + S + +E R A+++ QEQ KI A++ +
Sbjct: 1029 MEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYER---- 1084
Query: 221 ASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEA 280
L AA A+QA + + + + E +K +Q + + +ER + + +
Sbjct: 1085 ---ELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDE 1141
Query: 281 ADALLKAKEELEKMKSV----IENAKKKEVAGAKPHI-------TAAEGKLHNMIVDLDN 329
+ E+LEK + IE K VA K + + EGK I+++
Sbjct: 1142 VSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILR 1201
Query: 330 VVK--------KVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSV-SD 380
++ + + AQ E+ Q EL+ + + + L++ +V K M+ +
Sbjct: 1202 FIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEE 1261
Query: 381 LADKLSTDDL----NSLIAHAHRRIDQ-LNRELAEQKATEKQHITLALEKQKLEEKRAFD 435
L K T ++ N ++ R++Q L + A+ + E + L +L EK
Sbjct: 1262 LMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGML 1321
Query: 436 SAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELK 495
A K LE +A + + +D E R +L + HT ++ L + LK
Sbjct: 1322 QAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYR-KLLSEKEVHTKRIQQ-LTEEIGRLK 1379
Query: 496 SEF---------EQNLSEKLSEQELQFR---RLSQEQVDNFTLDI--------------- 528
+E QNL + L E + R Q+ +D +DI
Sbjct: 1380 AEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGR 1439
Query: 529 --NTAYARLRGIEQAV-QSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAV 585
T Y L+ + V ++ A + + ++ H ++ LK ++ + AET + L S V
Sbjct: 1440 RYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETL--NQAETKSKSLESQV 1497
Query: 586 EAIKANCSDNE 596
E ++ S+ E
Sbjct: 1498 ENLQKTLSEKE 1508
Score = 45.8 bits (107), Expect = 1e-04
Identities = 77/332 (23%), Positives = 139/332 (41%), Gaps = 68/332 (20%)
Query: 266 VEGALKERRKAVDEAADALLKAKEELEK---MKSVIENAK--KKEVAGAKPHITAAEGKL 320
++ +L R+ V A + + +E ++K M V+E K ++E + + + K+
Sbjct: 1238 LQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKV 1297
Query: 321 HNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMS--- 377
+ +D+ +++ A SE + Q + +++ +D KR WK +
Sbjct: 1298 RKLELDI-LPLQEANAELSEKSGMLQAEKKLLE--EDVKR------------WKARNQHL 1342
Query: 378 VSDLADKLSTDDLNSLIAHAH---RRIDQLNRELAEQKA---------TEKQHITLALEK 425
VS D T++ L++ +RI QL E+ KA T Q++ +L K
Sbjct: 1343 VSQQKDP-DTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSL-K 1400
Query: 426 QKLEEKRAFDSAVAKALEHHRSEIQAE-----QDRKIEEVRDAMENEMRTQ----LRRQA 476
+ L + R + K L+ +IQ + Q +KI E++ Q + A
Sbjct: 1401 EDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSA 1460
Query: 477 AAHTDHLRDVLRVQE-QELKSEFEQ-------------NLSEKLSEQELQFRRLSQEQVD 522
+ DH + VQE QELK Q NL + LSE+E + R L ++
Sbjct: 1461 QSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQ--- 1517
Query: 523 NFTLDINTAYARLRGIEQAVQSHAVAEEEARK 554
T+ + + +RLR Q +Q EE+ R+
Sbjct: 1518 --TVQLQSELSRLR---QDLQDRTTQEEQLRQ 1544
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 60.5 bits (145), Expect = 6e-09
Identities = 93/422 (22%), Positives = 168/422 (39%), Gaps = 68/422 (16%)
Query: 190 EVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAV----------- 238
++ RLAQ K ++E +ED LRQ V + +A + + +A
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 239 ----NAHSNILKAAMDNSEIAGEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKE 289
NA + E A +++ A + R E +++ A +EAA A E
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Query: 290 ELEKMKSVIENAK----------------------KKEVAGAKPHITAAEGKLHNMIVDL 327
E+E++K+ +E A+ K+ A K H A + K + L
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 328 DNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-- 385
+ + EA+ + E +AR +RE +V + A++L
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV----------EEAERLKQ 2119
Query: 386 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----A 441
S ++ A A ++L +E AEQ+A + E+ L +K+A D+ + K A
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKE-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFA 2174
Query: 442 LEHHRSEIQAEQD----RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 497
+ R + Q EQ+ R E D +N + +L+R A T+ R +V+E+
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 498 FE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 556
+ + LS+ + E + R L DN + +++ + + +VA +EA +
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294
Query: 557 QL 558
QL
Sbjct: 2295 QL 2296
Score = 60.1 bits (144), Expect = 7e-09
Identities = 106/527 (20%), Positives = 205/527 (38%), Gaps = 42/527 (7%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALS 175
E+ + +Q S L + +G+ A+ A + VQ E ++ E + +
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 176 EEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAV 235
EE + + + + E + A+QE + + E + ALRQ + + + A
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAE------QAALRQKQAADAEMEKHKKFAE 2175
Query: 236 QAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMK 295
Q + + + + + + E+ Q ++ L+ + EAA + +EEL ++
Sbjct: 2176 QTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 296 SVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQAR 355
+E E++ K I A L ++ D DN + +Q + K V++ + A
Sbjct: 2235 VQME-----ELSKLKARIEAENRAL--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287
Query: 356 DDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHAHRRIDQLNRELAEQKAT 414
+ R L + E L + ++ L +K+ + + L A A + Q +ELA+++A
Sbjct: 2288 QEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQAR 2344
Query: 415 EKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRR 474
Q + +Q EE + F ++AE+ R++E +A ++R
Sbjct: 2345 RLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMS 2393
Query: 475 QAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQFRRLSQEQVDNFTLDINT 530
+A A + R Q +E+ + + +L+ QE +Q + ++Q D+ +
Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 531 AYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVE 586
A A L ++ +Q A + EE + Q L E S + + +E
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510
Query: 587 AIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARR 633
KA + A E R E R R A + ARR
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557
Score = 58.5 bits (140), Expect = 2e-08
Identities = 111/530 (20%), Positives = 204/530 (38%), Gaps = 77/530 (14%)
Query: 153 QPEESLKTDHPEIGEGKPTPA--LSEEASSSSIRERPPEEV----------------AAR 194
Q E SL+ +H + + + ++A + RE E+ A
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650
Query: 195 LAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEI 254
+AQQ+ Q + E + E R+ QA+ + E+
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------EL 1689
Query: 255 AGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKP 311
A ++ Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1690 AEQELEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQ 1748
Query: 312 HITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLP 371
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL-- 1806
Query: 372 GWKGMSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKL 428
++++ A + L+ +D A A R + + + E K +AL++++
Sbjct: 1807 ----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEA 1861
Query: 429 EEKRAFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVL 487
E +R A +A + R E QA Q + IEE + ++L RQ D LR
Sbjct: 1862 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1921
Query: 488 RVQEQ--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------Y 532
+V+E+ LK+ FE+ + K +E EL+ R+ D ++ A
Sbjct: 1922 QVEEEILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980
Query: 533 ARLRGIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAV 585
R R E+ VQ AEEEA + + L VE LK ++ + + L A
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040
Query: 586 EAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 635
EA + E A + L + + E+++ + + ARR A
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Score = 56.6 bits (135), Expect = 8e-08
Identities = 87/400 (21%), Positives = 165/400 (41%), Gaps = 78/400 (19%)
Query: 164 EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 223
++ E E + +++R EEV R +Q K S+ + L+ LRQ++
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEA 1431
Query: 224 TLQAIAAQNAAVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 279
+QA A Q A + + +++ ++ +E Q EG L+ R +E
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEE 1484
Query: 280 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQ 338
A +A+EE E+++ +++ +++ V+L + VK + +AA+
Sbjct: 1485 AEAQKRQAQEEAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAR 1529
Query: 339 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAH 398
+ + + EL +QA + +R + EV + + A + + +L S A
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFA 1586
Query: 399 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 458
+ QL R L E+ H+ +A +++ E R++ QAE +R E
Sbjct: 1587 EKTAQLERSLQEE------HVAVAQLREEAER---------------RAQQQAEAERARE 1625
Query: 459 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQ 518
E +E R QL+ A LR+Q +E+ + + L++ E + ++
Sbjct: 1626 EAERELE---RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEA 1669
Query: 519 EQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 558
E+ A R + EQAV+ +AE+E K QL
Sbjct: 1670 ER---------EARRRGKAEEQAVRQRELAEQELEKQRQL 1700
Score = 48.1 bits (113), Expect = 3e-05
Identities = 121/577 (20%), Positives = 227/577 (39%), Gaps = 84/577 (14%)
Query: 109 LKISSVSEVMKESKQPASQLQKQ--------KGDTPASATAGDTLSVPAPAVQPEESLKT 160
L++ E +E Q ++ QK KG SA A L++P P+ P
Sbjct: 1007 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS--PAAPTLR 1064
Query: 161 DHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQT 220
E+ GK L + S S+I + ++ + + E+V + + + L++A Q
Sbjct: 1065 SELELTLGK----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQLKEA--QA 1117
Query: 221 ASVTLQAIAAQNAAVQAVNAHSNILKAAMD--NSEIAGEKKSAQ---------------W 263
TL + A A+++ + A + + D E+ G ++ + W
Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177
Query: 264 RTVEGALKERRKAVDEAADALLKAKEEL-----------EKMKSVIENAKKK-EVAGAKP 311
R L ER +AV D + E+L + + + +++A+++ E A P
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237
Query: 312 --HITAAEGKLHN---MIVDLDNVVKKVQAAQSEAK----VVSQYHELVVQARDDFKREL 362
A +L ++ +++ +KV+ Q AK + Y +V +K +L
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT----YKAQL 1293
Query: 363 DSIT-----PEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQ 417
+ + P+V G + + + + +L +L + + I + R + E++ +Q
Sbjct: 1294 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1353
Query: 418 HITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ----LR 473
A E+++L E A ALE R +A K + R+A E + R Q R
Sbjct: 1354 Q--RAEERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 474 RQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDINTA 531
+AA + ++ + Q+L+ E + K + E + R +E++ L +
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464
Query: 532 YARLRGIEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAVEA- 587
+ G E +Q+ A AEE + Q E L+ ++ S + L S V+A
Sbjct: 1465 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524
Query: 588 IKANCSDNEFTQAL-TAAIPPESLTRGVYSEETLRAR 623
+A QAL + E R + E RAR
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Score = 41.6 bits (96), Expect = 0.003
Identities = 77/357 (21%), Positives = 149/357 (41%), Gaps = 51/357 (14%)
Query: 167 EGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTL 225
E + ++EEA+ S+ + AARL Q +++ + +LA K L++ ++ T
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 226 QAIAAQNAAVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAAD 282
A+ Q A + D ++A E+ RT+E ER++ ++ +A+
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAE 2381
Query: 283 ALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQS 339
A E L+ + + A+ + A+ AE KLH + V VQ +
Sbjct: 2382 A-----ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 340 EAKVVSQYHELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDL 381
+ + E + +A + +RE + + E +L + + S L
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 382 ADKLSTDDLNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAV 438
++K S I +++QL ++ A+Q E+Q ++Q++E++R V
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLV 2549
Query: 439 AKALEHHRSEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 493
A E R + +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2604
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 60.5 bits (145), Expect = 6e-09
Identities = 93/422 (22%), Positives = 168/422 (39%), Gaps = 68/422 (16%)
Query: 190 EVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAV----------- 238
++ RLAQ K ++E +ED LRQ V + +A + + +A
Sbjct: 1894 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1953
Query: 239 ----NAHSNILKAAMDNSEIAGEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKE 289
NA + E A +++ A + R E +++ A +EAA A E
Sbjct: 1954 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2013
Query: 290 ELEKMKSVIENAK----------------------KKEVAGAKPHITAAEGKLHNMIVDL 327
E+E++K+ +E A+ K+ A K H A + K + L
Sbjct: 2014 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2073
Query: 328 DNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-- 385
+ + EA+ + E +AR +RE +V + A++L
Sbjct: 2074 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV----------EEAERLKQ 2123
Query: 386 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----A 441
S ++ A A ++L +E AEQ+A + E+ L +K+A D+ + K A
Sbjct: 2124 SAEEQAQARAQAQAAAEKLRKE-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFA 2178
Query: 442 LEHHRSEIQAEQD----RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 497
+ R + Q EQ+ R E D +N + +L+R A T+ R +V+E+
Sbjct: 2179 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2238
Query: 498 FE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 556
+ + LS+ + E + R L DN + +++ + + +VA +EA +
Sbjct: 2239 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2298
Query: 557 QL 558
QL
Sbjct: 2299 QL 2300
Score = 60.1 bits (144), Expect = 7e-09
Identities = 106/527 (20%), Positives = 205/527 (38%), Gaps = 42/527 (7%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALS 175
E+ + +Q S L + +G+ A+ A + VQ E ++ E + +
Sbjct: 2068 ELQQTLQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVEEAERLKQSA 2125
Query: 176 EEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAV 235
EE + + + + E + A+QE + + E + ALRQ + + + A
Sbjct: 2126 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAE------QAALRQKQAADAEMEKHKKFAE 2179
Query: 236 QAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMK 295
Q + + + + + + E+ Q ++ L+ + EAA + +EEL ++
Sbjct: 2180 QTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2238
Query: 296 SVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQAR 355
+E E++ K I A L ++ D DN + +Q + K V++ + A
Sbjct: 2239 VQME-----ELSKLKARIEAENRAL--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2291
Query: 356 DDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHAHRRIDQLNRELAEQKAT 414
+ R L + E L + ++ L +K+ + + L A A + Q +ELA+++A
Sbjct: 2292 QEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQAR 2348
Query: 415 EKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRR 474
Q + +Q EE + F ++AE+ R++E +A ++R
Sbjct: 2349 RLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMS 2397
Query: 475 QAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQFRRLSQEQVDNFTLDINT 530
+A A + R Q +E+ + + +L+ QE +Q + ++Q D+ +
Sbjct: 2398 RAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQRQQSDHDAERLRE 2454
Query: 531 AYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVE 586
A A L ++ +Q A + EE + Q L E S + + +E
Sbjct: 2455 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2514
Query: 587 AIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARR 633
KA + A E R E R R A + ARR
Sbjct: 2515 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2561
Score = 58.5 bits (140), Expect = 2e-08
Identities = 111/530 (20%), Positives = 204/530 (38%), Gaps = 77/530 (14%)
Query: 153 QPEESLKTDHPEIGEGKPTPA--LSEEASSSSIRERPPEEV----------------AAR 194
Q E SL+ +H + + + ++A + RE E+ A
Sbjct: 1595 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1654
Query: 195 LAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEI 254
+AQQ+ Q + E + E R+ QA+ + E+
Sbjct: 1655 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------EL 1693
Query: 255 AGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKP 311
A ++ Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1694 AEQELEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQ 1752
Query: 312 HITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLP 371
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1753 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL-- 1810
Query: 372 GWKGMSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKL 428
++++ A + L+ +D A A R + + + E K +AL++++
Sbjct: 1811 ----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEA 1865
Query: 429 EEKRAFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVL 487
E +R A +A + R E QA Q + IEE + ++L RQ D LR
Sbjct: 1866 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1925
Query: 488 RVQEQ--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------Y 532
+V+E+ LK+ FE+ + K +E EL+ R+ D ++ A
Sbjct: 1926 QVEEEILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1984
Query: 533 ARLRGIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAV 585
R R E+ VQ AEEEA + + L VE LK ++ + + L A
Sbjct: 1985 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2044
Query: 586 EAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 635
EA + E A + L + + E+++ + + ARR A
Sbjct: 2045 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2094
Score = 56.6 bits (135), Expect = 8e-08
Identities = 87/400 (21%), Positives = 165/400 (41%), Gaps = 78/400 (19%)
Query: 164 EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 223
++ E E + +++R EEV R +Q K S+ + L+ LRQ++
Sbjct: 1378 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEA 1435
Query: 224 TLQAIAAQNAAVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 279
+QA A Q A + + +++ ++ +E Q EG L+ R +E
Sbjct: 1436 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEE 1488
Query: 280 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQ 338
A +A+EE E+++ +++ +++ V+L + VK + +AA+
Sbjct: 1489 AEAQKRQAQEEAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAR 1533
Query: 339 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAH 398
+ + + EL +QA + +R + EV + + A + + +L S A
Sbjct: 1534 EKQRALQALEELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFA 1590
Query: 399 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 458
+ QL R L E+ H+ +A +++ E R++ QAE +R E
Sbjct: 1591 EKTAQLERSLQEE------HVAVAQLREEAER---------------RAQQQAEAERARE 1629
Query: 459 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQ 518
E +E R QL+ A LR+Q +E+ + + L++ E + ++
Sbjct: 1630 EAERELE---RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEA 1673
Query: 519 EQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 558
E+ A R + EQAV+ +AE+E K QL
Sbjct: 1674 ER---------EARRRGKAEEQAVRQRELAEQELEKQRQL 1704
Score = 48.1 bits (113), Expect = 3e-05
Identities = 121/577 (20%), Positives = 227/577 (39%), Gaps = 84/577 (14%)
Query: 109 LKISSVSEVMKESKQPASQLQKQ--------KGDTPASATAGDTLSVPAPAVQPEESLKT 160
L++ E +E Q ++ QK KG SA A L++P P+ P
Sbjct: 1011 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS--PAAPTLR 1068
Query: 161 DHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQT 220
E+ GK L + S S+I + ++ + + E+V + + + L++A Q
Sbjct: 1069 SELELTLGK----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQLKEA--QA 1121
Query: 221 ASVTLQAIAAQNAAVQAVNAHSNILKAAMD--NSEIAGEKKSAQ---------------W 263
TL + A A+++ + A + + D E+ G ++ + W
Sbjct: 1122 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1181
Query: 264 RTVEGALKERRKAVDEAADALLKAKEEL-----------EKMKSVIENAKKK-EVAGAKP 311
R L ER +AV D + E+L + + + +++A+++ E A P
Sbjct: 1182 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1241
Query: 312 --HITAAEGKLHN---MIVDLDNVVKKVQAAQSEAK----VVSQYHELVVQARDDFKREL 362
A +L ++ +++ +KV+ Q AK + Y +V +K +L
Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT----YKAQL 1297
Query: 363 DSIT-----PEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQ 417
+ + P+V G + + + + +L +L + + I + R + E++ +Q
Sbjct: 1298 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1357
Query: 418 HITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ----LR 473
A E+++L E A ALE R +A K + R+A E + R Q R
Sbjct: 1358 Q--RAEERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1408
Query: 474 RQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDINTA 531
+AA + ++ + Q+L+ E + K + E + R +E++ L +
Sbjct: 1409 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1468
Query: 532 YARLRGIEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAVEA- 587
+ G E +Q+ A AEE + Q E L+ ++ S + L S V+A
Sbjct: 1469 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1528
Query: 588 IKANCSDNEFTQAL-TAAIPPESLTRGVYSEETLRAR 623
+A QAL + E R + E RAR
Sbjct: 1529 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1565
Score = 41.6 bits (96), Expect = 0.003
Identities = 77/357 (21%), Positives = 149/357 (41%), Gaps = 51/357 (14%)
Query: 167 EGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTL 225
E + ++EEA+ S+ + AARL Q +++ + +LA K L++ ++ T
Sbjct: 2273 EAEKMKQVAEEAARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328
Query: 226 QAIAAQNAAVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAAD 282
A+ Q A + D ++A E+ RT+E ER++ ++ +A+
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAE 2385
Query: 283 ALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQS 339
A E L+ + + A+ + A+ AE KLH + V VQ +
Sbjct: 2386 A-----ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2440
Query: 340 EAKVVSQYHELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDL 381
+ + E + +A + +RE + + E +L + + S L
Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2500
Query: 382 ADKLSTDDLNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAV 438
++K S I +++QL ++ A+Q E+Q ++Q++E++R V
Sbjct: 2501 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLV 2553
Query: 439 AKALEHHRSEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 493
A E R + +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2554 ASMEEARRRQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2608
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 60.5 bits (145), Expect = 6e-09
Identities = 93/422 (22%), Positives = 168/422 (39%), Gaps = 68/422 (16%)
Query: 190 EVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAV----------- 238
++ RLAQ K ++E +ED LRQ V + +A + + +A
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 239 ----NAHSNILKAAMDNSEIAGEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKE 289
NA + E A +++ A + R E +++ A +EAA A E
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Query: 290 ELEKMKSVIENAK----------------------KKEVAGAKPHITAAEGKLHNMIVDL 327
E+E++K+ +E A+ K+ A K H A + K + L
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 328 DNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-- 385
+ + EA+ + E +AR +RE +V + A++L
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV----------EEAERLKQ 2119
Query: 386 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----A 441
S ++ A A ++L +E AEQ+A + E+ L +K+A D+ + K A
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKE-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFA 2174
Query: 442 LEHHRSEIQAEQD----RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 497
+ R + Q EQ+ R E D +N + +L+R A T+ R +V+E+
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 498 FE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 556
+ + LS+ + E + R L DN + +++ + + +VA +EA +
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294
Query: 557 QL 558
QL
Sbjct: 2295 QL 2296
Score = 60.1 bits (144), Expect = 7e-09
Identities = 106/527 (20%), Positives = 205/527 (38%), Gaps = 42/527 (7%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALS 175
E+ + +Q S L + +G+ A+ A + VQ E ++ E + +
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 176 EEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAV 235
EE + + + + E + A+QE + + E + ALRQ + + + A
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAE------QAALRQKQAADAEMEKHKKFAE 2175
Query: 236 QAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMK 295
Q + + + + + + E+ Q ++ L+ + EAA + +EEL ++
Sbjct: 2176 QTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 296 SVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQAR 355
+E E++ K I A L ++ D DN + +Q + K V++ + A
Sbjct: 2235 VQME-----ELSKLKARIEAENRAL--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287
Query: 356 DDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHAHRRIDQLNRELAEQKAT 414
+ R L + E L + ++ L +K+ + + L A A + Q +ELA+++A
Sbjct: 2288 QEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQAR 2344
Query: 415 EKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRR 474
Q + +Q EE + F ++AE+ R++E +A ++R
Sbjct: 2345 RLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMS 2393
Query: 475 QAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQFRRLSQEQVDNFTLDINT 530
+A A + R Q +E+ + + +L+ QE +Q + ++Q D+ +
Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 531 AYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVE 586
A A L ++ +Q A + EE + Q L E S + + +E
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510
Query: 587 AIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARR 633
KA + A E R E R R A + ARR
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557
Score = 58.5 bits (140), Expect = 2e-08
Identities = 111/530 (20%), Positives = 204/530 (38%), Gaps = 77/530 (14%)
Query: 153 QPEESLKTDHPEIGEGKPTPA--LSEEASSSSIRERPPEEV----------------AAR 194
Q E SL+ +H + + + ++A + RE E+ A
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650
Query: 195 LAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEI 254
+AQQ+ Q + E + E R+ QA+ + E+
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------EL 1689
Query: 255 AGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKP 311
A ++ Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1690 AEQELEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQ 1748
Query: 312 HITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLP 371
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL-- 1806
Query: 372 GWKGMSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKL 428
++++ A + L+ +D A A R + + + E K +AL++++
Sbjct: 1807 ----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEA 1861
Query: 429 EEKRAFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVL 487
E +R A +A + R E QA Q + IEE + ++L RQ D LR
Sbjct: 1862 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1921
Query: 488 RVQEQ--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------Y 532
+V+E+ LK+ FE+ + K +E EL+ R+ D ++ A
Sbjct: 1922 QVEEEILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980
Query: 533 ARLRGIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAV 585
R R E+ VQ AEEEA + + L VE LK ++ + + L A
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040
Query: 586 EAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 635
EA + E A + L + + E+++ + + ARR A
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Score = 56.6 bits (135), Expect = 8e-08
Identities = 87/400 (21%), Positives = 165/400 (41%), Gaps = 78/400 (19%)
Query: 164 EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 223
++ E E + +++R EEV R +Q K S+ + L+ LRQ++
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEA 1431
Query: 224 TLQAIAAQNAAVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 279
+QA A Q A + + +++ ++ +E Q EG L+ R +E
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEE 1484
Query: 280 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQ 338
A +A+EE E+++ +++ +++ V+L + VK + +AA+
Sbjct: 1485 AEAQKRQAQEEAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAR 1529
Query: 339 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAH 398
+ + + EL +QA + +R + EV + + A + + +L S A
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFA 1586
Query: 399 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 458
+ QL R L E+ H+ +A +++ E R++ QAE +R E
Sbjct: 1587 EKTAQLERSLQEE------HVAVAQLREEAER---------------RAQQQAEAERARE 1625
Query: 459 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQ 518
E +E R QL+ A LR+Q +E+ + + L++ E + ++
Sbjct: 1626 EAERELE---RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEA 1669
Query: 519 EQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 558
E+ A R + EQAV+ +AE+E K QL
Sbjct: 1670 ER---------EARRRGKAEEQAVRQRELAEQELEKQRQL 1700
Score = 48.1 bits (113), Expect = 3e-05
Identities = 121/577 (20%), Positives = 227/577 (39%), Gaps = 84/577 (14%)
Query: 109 LKISSVSEVMKESKQPASQLQKQ--------KGDTPASATAGDTLSVPAPAVQPEESLKT 160
L++ E +E Q ++ QK KG SA A L++P P+ P
Sbjct: 1007 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS--PAAPTLR 1064
Query: 161 DHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQT 220
E+ GK L + S S+I + ++ + + E+V + + + L++A Q
Sbjct: 1065 SELELTLGK----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQLKEA--QA 1117
Query: 221 ASVTLQAIAAQNAAVQAVNAHSNILKAAMD--NSEIAGEKKSAQ---------------W 263
TL + A A+++ + A + + D E+ G ++ + W
Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177
Query: 264 RTVEGALKERRKAVDEAADALLKAKEEL-----------EKMKSVIENAKKK-EVAGAKP 311
R L ER +AV D + E+L + + + +++A+++ E A P
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237
Query: 312 --HITAAEGKLHN---MIVDLDNVVKKVQAAQSEAK----VVSQYHELVVQARDDFKREL 362
A +L ++ +++ +KV+ Q AK + Y +V +K +L
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT----YKAQL 1293
Query: 363 DSIT-----PEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQ 417
+ + P+V G + + + + +L +L + + I + R + E++ +Q
Sbjct: 1294 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1353
Query: 418 HITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ----LR 473
A E+++L E A ALE R +A K + R+A E + R Q R
Sbjct: 1354 Q--RAEERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 474 RQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDINTA 531
+AA + ++ + Q+L+ E + K + E + R +E++ L +
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464
Query: 532 YARLRGIEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAVEA- 587
+ G E +Q+ A AEE + Q E L+ ++ S + L S V+A
Sbjct: 1465 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524
Query: 588 IKANCSDNEFTQAL-TAAIPPESLTRGVYSEETLRAR 623
+A QAL + E R + E RAR
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Score = 41.6 bits (96), Expect = 0.003
Identities = 77/357 (21%), Positives = 149/357 (41%), Gaps = 51/357 (14%)
Query: 167 EGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTL 225
E + ++EEA+ S+ + AARL Q +++ + +LA K L++ ++ T
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 226 QAIAAQNAAVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAAD 282
A+ Q A + D ++A E+ RT+E ER++ ++ +A+
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAE 2381
Query: 283 ALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQS 339
A E L+ + + A+ + A+ AE KLH + V VQ +
Sbjct: 2382 A-----ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 340 EAKVVSQYHELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDL 381
+ + E + +A + +RE + + E +L + + S L
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 382 ADKLSTDDLNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAV 438
++K S I +++QL ++ A+Q E+Q ++Q++E++R V
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLV 2549
Query: 439 AKALEHHRSEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 493
A E R + +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2604
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 60.5 bits (145), Expect = 6e-09
Identities = 93/422 (22%), Positives = 168/422 (39%), Gaps = 68/422 (16%)
Query: 190 EVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAV----------- 238
++ RLAQ K ++E +ED LRQ V + +A + + +A
Sbjct: 1858 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1917
Query: 239 ----NAHSNILKAAMDNSEIAGEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKE 289
NA + E A +++ A + R E +++ A +EAA A E
Sbjct: 1918 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1977
Query: 290 ELEKMKSVIENAK----------------------KKEVAGAKPHITAAEGKLHNMIVDL 327
E+E++K+ +E A+ K+ A K H A + K + L
Sbjct: 1978 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2037
Query: 328 DNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-- 385
+ + EA+ + E +AR +RE +V + A++L
Sbjct: 2038 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV----------EEAERLKQ 2087
Query: 386 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----A 441
S ++ A A ++L +E AEQ+A + E+ L +K+A D+ + K A
Sbjct: 2088 SAEEQAQARAQAQAAAEKLRKE-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFA 2142
Query: 442 LEHHRSEIQAEQD----RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 497
+ R + Q EQ+ R E D +N + +L+R A T+ R +V+E+
Sbjct: 2143 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2202
Query: 498 FE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 556
+ + LS+ + E + R L DN + +++ + + +VA +EA +
Sbjct: 2203 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2262
Query: 557 QL 558
QL
Sbjct: 2263 QL 2264
Score = 60.1 bits (144), Expect = 7e-09
Identities = 106/527 (20%), Positives = 205/527 (38%), Gaps = 42/527 (7%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALS 175
E+ + +Q S L + +G+ A+ A + VQ E ++ E + +
Sbjct: 2032 ELQQTLQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVEEAERLKQSA 2089
Query: 176 EEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAV 235
EE + + + + E + A+QE + + E + ALRQ + + + A
Sbjct: 2090 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAE------QAALRQKQAADAEMEKHKKFAE 2143
Query: 236 QAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMK 295
Q + + + + + + E+ Q ++ L+ + EAA + +EEL ++
Sbjct: 2144 QTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2202
Query: 296 SVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQAR 355
+E E++ K I A L ++ D DN + +Q + K V++ + A
Sbjct: 2203 VQME-----ELSKLKARIEAENRAL--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2255
Query: 356 DDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHAHRRIDQLNRELAEQKAT 414
+ R L + E L + ++ L +K+ + + L A A + Q +ELA+++A
Sbjct: 2256 QEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQAR 2312
Query: 415 EKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRR 474
Q + +Q EE + F ++AE+ R++E +A ++R
Sbjct: 2313 RLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMS 2361
Query: 475 QAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQFRRLSQEQVDNFTLDINT 530
+A A + R Q +E+ + + +L+ QE +Q + ++Q D+ +
Sbjct: 2362 RAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQRQQSDHDAERLRE 2418
Query: 531 AYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVE 586
A A L ++ +Q A + EE + Q L E S + + +E
Sbjct: 2419 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2478
Query: 587 AIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARR 633
KA + A E R E R R A + ARR
Sbjct: 2479 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2525
Score = 58.5 bits (140), Expect = 2e-08
Identities = 111/530 (20%), Positives = 204/530 (38%), Gaps = 77/530 (14%)
Query: 153 QPEESLKTDHPEIGEGKPTPA--LSEEASSSSIRERPPEEV----------------AAR 194
Q E SL+ +H + + + ++A + RE E+ A
Sbjct: 1559 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1618
Query: 195 LAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEI 254
+AQQ+ Q + E + E R+ QA+ + E+
Sbjct: 1619 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------EL 1657
Query: 255 AGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKP 311
A ++ Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1658 AEQELEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQ 1716
Query: 312 HITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLP 371
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1717 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL-- 1774
Query: 372 GWKGMSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKL 428
++++ A + L+ +D A A R + + + E K +AL++++
Sbjct: 1775 ----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEA 1829
Query: 429 EEKRAFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVL 487
E +R A +A + R E QA Q + IEE + ++L RQ D LR
Sbjct: 1830 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1889
Query: 488 RVQEQ--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------Y 532
+V+E+ LK+ FE+ + K +E EL+ R+ D ++ A
Sbjct: 1890 QVEEEILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1948
Query: 533 ARLRGIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAV 585
R R E+ VQ AEEEA + + L VE LK ++ + + L A
Sbjct: 1949 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2008
Query: 586 EAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 635
EA + E A + L + + E+++ + + ARR A
Sbjct: 2009 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2058
Score = 56.6 bits (135), Expect = 8e-08
Identities = 87/400 (21%), Positives = 165/400 (41%), Gaps = 78/400 (19%)
Query: 164 EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 223
++ E E + +++R EEV R +Q K S+ + L+ LRQ++
Sbjct: 1342 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEA 1399
Query: 224 TLQAIAAQNAAVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 279
+QA A Q A + + +++ ++ +E Q EG L+ R +E
Sbjct: 1400 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEE 1452
Query: 280 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQ 338
A +A+EE E+++ +++ +++ V+L + VK + +AA+
Sbjct: 1453 AEAQKRQAQEEAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAR 1497
Query: 339 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAH 398
+ + + EL +QA + +R + EV + + A + + +L S A
Sbjct: 1498 EKQRALQALEELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFA 1554
Query: 399 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 458
+ QL R L E+ H+ +A +++ E R++ QAE +R E
Sbjct: 1555 EKTAQLERSLQEE------HVAVAQLREEAER---------------RAQQQAEAERARE 1593
Query: 459 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQ 518
E +E R QL+ A LR+Q +E+ + + L++ E + ++
Sbjct: 1594 EAERELE---RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEA 1637
Query: 519 EQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 558
E+ A R + EQAV+ +AE+E K QL
Sbjct: 1638 ER---------EARRRGKAEEQAVRQRELAEQELEKQRQL 1668
Score = 48.1 bits (113), Expect = 3e-05
Identities = 121/577 (20%), Positives = 227/577 (39%), Gaps = 84/577 (14%)
Query: 109 LKISSVSEVMKESKQPASQLQKQ--------KGDTPASATAGDTLSVPAPAVQPEESLKT 160
L++ E +E Q ++ QK KG SA A L++P P+ P
Sbjct: 975 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS--PAAPTLR 1032
Query: 161 DHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQT 220
E+ GK L + S S+I + ++ + + E+V + + + L++A Q
Sbjct: 1033 SELELTLGK----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQLKEA--QA 1085
Query: 221 ASVTLQAIAAQNAAVQAVNAHSNILKAAMD--NSEIAGEKKSAQ---------------W 263
TL + A A+++ + A + + D E+ G ++ + W
Sbjct: 1086 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1145
Query: 264 RTVEGALKERRKAVDEAADALLKAKEEL-----------EKMKSVIENAKKK-EVAGAKP 311
R L ER +AV D + E+L + + + +++A+++ E A P
Sbjct: 1146 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1205
Query: 312 --HITAAEGKLHN---MIVDLDNVVKKVQAAQSEAK----VVSQYHELVVQARDDFKREL 362
A +L ++ +++ +KV+ Q AK + Y +V +K +L
Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT----YKAQL 1261
Query: 363 DSIT-----PEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQ 417
+ + P+V G + + + + +L +L + + I + R + E++ +Q
Sbjct: 1262 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1321
Query: 418 HITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ----LR 473
A E+++L E A ALE R +A K + R+A E + R Q R
Sbjct: 1322 Q--RAEERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1372
Query: 474 RQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDINTA 531
+AA + ++ + Q+L+ E + K + E + R +E++ L +
Sbjct: 1373 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1432
Query: 532 YARLRGIEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAVEA- 587
+ G E +Q+ A AEE + Q E L+ ++ S + L S V+A
Sbjct: 1433 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1492
Query: 588 IKANCSDNEFTQAL-TAAIPPESLTRGVYSEETLRAR 623
+A QAL + E R + E RAR
Sbjct: 1493 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1529
Score = 41.6 bits (96), Expect = 0.003
Identities = 77/357 (21%), Positives = 149/357 (41%), Gaps = 51/357 (14%)
Query: 167 EGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTL 225
E + ++EEA+ S+ + AARL Q +++ + +LA K L++ ++ T
Sbjct: 2237 EAEKMKQVAEEAARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292
Query: 226 QAIAAQNAAVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAAD 282
A+ Q A + D ++A E+ RT+E ER++ ++ +A+
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAE 2349
Query: 283 ALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQS 339
A E L+ + + A+ + A+ AE KLH + V VQ +
Sbjct: 2350 A-----ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2404
Query: 340 EAKVVSQYHELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDL 381
+ + E + +A + +RE + + E +L + + S L
Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2464
Query: 382 ADKLSTDDLNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAV 438
++K S I +++QL ++ A+Q E+Q ++Q++E++R V
Sbjct: 2465 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLV 2517
Query: 439 AKALEHHRSEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 493
A E R + +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2518 ASMEEARRRQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2572
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 60.5 bits (145), Expect = 6e-09
Identities = 93/422 (22%), Positives = 168/422 (39%), Gaps = 68/422 (16%)
Query: 190 EVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAV----------- 238
++ RLAQ K ++E +ED LRQ V + +A + + +A
Sbjct: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086
Query: 239 ----NAHSNILKAAMDNSEIAGEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKE 289
NA + E A +++ A + R E +++ A +EAA A E
Sbjct: 2087 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2146
Query: 290 ELEKMKSVIENAK----------------------KKEVAGAKPHITAAEGKLHNMIVDL 327
E+E++K+ +E A+ K+ A K H A + K + L
Sbjct: 2147 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2206
Query: 328 DNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-- 385
+ + EA+ + E +AR +RE +V + A++L
Sbjct: 2207 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV----------EEAERLKQ 2256
Query: 386 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----A 441
S ++ A A ++L +E AEQ+A + E+ L +K+A D+ + K A
Sbjct: 2257 SAEEQAQARAQAQAAAEKLRKE-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFA 2311
Query: 442 LEHHRSEIQAEQD----RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 497
+ R + Q EQ+ R E D +N + +L+R A T+ R +V+E+
Sbjct: 2312 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2371
Query: 498 FE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 556
+ + LS+ + E + R L DN + +++ + + +VA +EA +
Sbjct: 2372 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2431
Query: 557 QL 558
QL
Sbjct: 2432 QL 2433
Score = 60.1 bits (144), Expect = 7e-09
Identities = 106/527 (20%), Positives = 205/527 (38%), Gaps = 42/527 (7%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALS 175
E+ + +Q S L + +G+ A+ A + VQ E ++ E + +
Sbjct: 2201 ELQQTLQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVEEAERLKQSA 2258
Query: 176 EEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAV 235
EE + + + + E + A+QE + + E + ALRQ + + + A
Sbjct: 2259 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAE------QAALRQKQAADAEMEKHKKFAE 2312
Query: 236 QAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMK 295
Q + + + + + + E+ Q ++ L+ + EAA + +EEL ++
Sbjct: 2313 QTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2371
Query: 296 SVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQAR 355
+E E++ K I A L ++ D DN + +Q + K V++ + A
Sbjct: 2372 VQME-----ELSKLKARIEAENRAL--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2424
Query: 356 DDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHAHRRIDQLNRELAEQKAT 414
+ R L + E L + ++ L +K+ + + L A A + Q +ELA+++A
Sbjct: 2425 QEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQAR 2481
Query: 415 EKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRR 474
Q + +Q EE + F ++AE+ R++E +A ++R
Sbjct: 2482 RLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMS 2530
Query: 475 QAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQFRRLSQEQVDNFTLDINT 530
+A A + R Q +E+ + + +L+ QE +Q + ++Q D+ +
Sbjct: 2531 RAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587
Query: 531 AYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVE 586
A A L ++ +Q A + EE + Q L E S + + +E
Sbjct: 2588 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2647
Query: 587 AIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARR 633
KA + A E R E R R A + ARR
Sbjct: 2648 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2694
Score = 58.5 bits (140), Expect = 2e-08
Identities = 111/530 (20%), Positives = 204/530 (38%), Gaps = 77/530 (14%)
Query: 153 QPEESLKTDHPEIGEGKPTPA--LSEEASSSSIRERPPEEV----------------AAR 194
Q E SL+ +H + + + ++A + RE E+ A
Sbjct: 1728 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1787
Query: 195 LAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEI 254
+AQQ+ Q + E + E R+ QA+ + E+
Sbjct: 1788 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------EL 1826
Query: 255 AGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKP 311
A ++ Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1827 AEQELEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQ 1885
Query: 312 HITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLP 371
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1886 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL-- 1943
Query: 372 GWKGMSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKL 428
++++ A + L+ +D A A R + + + E K +AL++++
Sbjct: 1944 ----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEA 1998
Query: 429 EEKRAFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVL 487
E +R A +A + R E QA Q + IEE + ++L RQ D LR
Sbjct: 1999 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 2058
Query: 488 RVQEQ--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------Y 532
+V+E+ LK+ FE+ + K +E EL+ R+ D ++ A
Sbjct: 2059 QVEEEILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2117
Query: 533 ARLRGIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAV 585
R R E+ VQ AEEEA + + L VE LK ++ + + L A
Sbjct: 2118 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2177
Query: 586 EAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 635
EA + E A + L + + E+++ + + ARR A
Sbjct: 2178 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2227
Score = 56.6 bits (135), Expect = 8e-08
Identities = 87/400 (21%), Positives = 165/400 (41%), Gaps = 78/400 (19%)
Query: 164 EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 223
++ E E + +++R EEV R +Q K S+ + L+ LRQ++
Sbjct: 1511 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEA 1568
Query: 224 TLQAIAAQNAAVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 279
+QA A Q A + + +++ ++ +E Q EG L+ R +E
Sbjct: 1569 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEE 1621
Query: 280 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQ 338
A +A+EE E+++ +++ +++ V+L + VK + +AA+
Sbjct: 1622 AEAQKRQAQEEAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAR 1666
Query: 339 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAH 398
+ + + EL +QA + +R + EV + + A + + +L S A
Sbjct: 1667 EKQRALQALEELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFA 1723
Query: 399 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 458
+ QL R L E+ H+ +A +++ E R++ QAE +R E
Sbjct: 1724 EKTAQLERSLQEE------HVAVAQLREEAER---------------RAQQQAEAERARE 1762
Query: 459 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQ 518
E +E R QL+ A LR+Q +E+ + + L++ E + ++
Sbjct: 1763 EAERELE---RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEA 1806
Query: 519 EQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 558
E+ A R + EQAV+ +AE+E K QL
Sbjct: 1807 ER---------EARRRGKAEEQAVRQRELAEQELEKQRQL 1837
Score = 48.1 bits (113), Expect = 3e-05
Identities = 121/577 (20%), Positives = 227/577 (39%), Gaps = 84/577 (14%)
Query: 109 LKISSVSEVMKESKQPASQLQKQ--------KGDTPASATAGDTLSVPAPAVQPEESLKT 160
L++ E +E Q ++ QK KG SA A L++P P+ P
Sbjct: 1144 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS--PAAPTLR 1201
Query: 161 DHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQT 220
E+ GK L + S S+I + ++ + + E+V + + + L++A Q
Sbjct: 1202 SELELTLGK----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQLKEA--QA 1254
Query: 221 ASVTLQAIAAQNAAVQAVNAHSNILKAAMD--NSEIAGEKKSAQ---------------W 263
TL + A A+++ + A + + D E+ G ++ + W
Sbjct: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314
Query: 264 RTVEGALKERRKAVDEAADALLKAKEEL-----------EKMKSVIENAKKK-EVAGAKP 311
R L ER +AV D + E+L + + + +++A+++ E A P
Sbjct: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374
Query: 312 --HITAAEGKLHN---MIVDLDNVVKKVQAAQSEAK----VVSQYHELVVQARDDFKREL 362
A +L ++ +++ +KV+ Q AK + Y +V +K +L
Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT----YKAQL 1430
Query: 363 DSIT-----PEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQ 417
+ + P+V G + + + + +L +L + + I + R + E++ +Q
Sbjct: 1431 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1490
Query: 418 HITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ----LR 473
A E+++L E A ALE R +A K + R+A E + R Q R
Sbjct: 1491 Q--RAEERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1541
Query: 474 RQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDINTA 531
+AA + ++ + Q+L+ E + K + E + R +E++ L +
Sbjct: 1542 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1601
Query: 532 YARLRGIEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAVEA- 587
+ G E +Q+ A AEE + Q E L+ ++ S + L S V+A
Sbjct: 1602 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1661
Query: 588 IKANCSDNEFTQAL-TAAIPPESLTRGVYSEETLRAR 623
+A QAL + E R + E RAR
Sbjct: 1662 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1698
Score = 41.6 bits (96), Expect = 0.003
Identities = 77/357 (21%), Positives = 149/357 (41%), Gaps = 51/357 (14%)
Query: 167 EGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTL 225
E + ++EEA+ S+ + AARL Q +++ + +LA K L++ ++ T
Sbjct: 2406 EAEKMKQVAEEAARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461
Query: 226 QAIAAQNAAVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAAD 282
A+ Q A + D ++A E+ RT+E ER++ ++ +A+
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAE 2518
Query: 283 ALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQS 339
A E L+ + + A+ + A+ AE KLH + V VQ +
Sbjct: 2519 A-----ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2573
Query: 340 EAKVVSQYHELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDL 381
+ + E + +A + +RE + + E +L + + S L
Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2633
Query: 382 ADKLSTDDLNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAV 438
++K S I +++QL ++ A+Q E+Q ++Q++E++R V
Sbjct: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLV 2686
Query: 439 AKALEHHRSEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 493
A E R + +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2687 ASMEEARRRQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2741
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 60.5 bits (145), Expect = 6e-09
Identities = 93/422 (22%), Positives = 168/422 (39%), Gaps = 68/422 (16%)
Query: 190 EVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAV----------- 238
++ RLAQ K ++E +ED LRQ V + +A + + +A
Sbjct: 1868 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1927
Query: 239 ----NAHSNILKAAMDNSEIAGEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKE 289
NA + E A +++ A + R E +++ A +EAA A E
Sbjct: 1928 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1987
Query: 290 ELEKMKSVIENAK----------------------KKEVAGAKPHITAAEGKLHNMIVDL 327
E+E++K+ +E A+ K+ A K H A + K + L
Sbjct: 1988 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2047
Query: 328 DNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-- 385
+ + EA+ + E +AR +RE +V + A++L
Sbjct: 2048 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV----------EEAERLKQ 2097
Query: 386 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----A 441
S ++ A A ++L +E AEQ+A + E+ L +K+A D+ + K A
Sbjct: 2098 SAEEQAQARAQAQAAAEKLRKE-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFA 2152
Query: 442 LEHHRSEIQAEQD----RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 497
+ R + Q EQ+ R E D +N + +L+R A T+ R +V+E+
Sbjct: 2153 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2212
Query: 498 FE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 556
+ + LS+ + E + R L DN + +++ + + +VA +EA +
Sbjct: 2213 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2272
Query: 557 QL 558
QL
Sbjct: 2273 QL 2274
Score = 60.1 bits (144), Expect = 7e-09
Identities = 106/527 (20%), Positives = 205/527 (38%), Gaps = 42/527 (7%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALS 175
E+ + +Q S L + +G+ A+ A + VQ E ++ E + +
Sbjct: 2042 ELQQTLQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVEEAERLKQSA 2099
Query: 176 EEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAV 235
EE + + + + E + A+QE + + E + ALRQ + + + A
Sbjct: 2100 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAE------QAALRQKQAADAEMEKHKKFAE 2153
Query: 236 QAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMK 295
Q + + + + + + E+ Q ++ L+ + EAA + +EEL ++
Sbjct: 2154 QTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2212
Query: 296 SVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQAR 355
+E E++ K I A L ++ D DN + +Q + K V++ + A
Sbjct: 2213 VQME-----ELSKLKARIEAENRAL--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2265
Query: 356 DDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHAHRRIDQLNRELAEQKAT 414
+ R L + E L + ++ L +K+ + + L A A + Q +ELA+++A
Sbjct: 2266 QEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQAR 2322
Query: 415 EKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRR 474
Q + +Q EE + F ++AE+ R++E +A ++R
Sbjct: 2323 RLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMS 2371
Query: 475 QAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQFRRLSQEQVDNFTLDINT 530
+A A + R Q +E+ + + +L+ QE +Q + ++Q D+ +
Sbjct: 2372 RAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQRQQSDHDAERLRE 2428
Query: 531 AYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVE 586
A A L ++ +Q A + EE + Q L E S + + +E
Sbjct: 2429 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2488
Query: 587 AIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARR 633
KA + A E R E R R A + ARR
Sbjct: 2489 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2535
Score = 58.5 bits (140), Expect = 2e-08
Identities = 111/530 (20%), Positives = 204/530 (38%), Gaps = 77/530 (14%)
Query: 153 QPEESLKTDHPEIGEGKPTPA--LSEEASSSSIRERPPEEV----------------AAR 194
Q E SL+ +H + + + ++A + RE E+ A
Sbjct: 1569 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1628
Query: 195 LAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEI 254
+AQQ+ Q + E + E R+ QA+ + E+
Sbjct: 1629 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------EL 1667
Query: 255 AGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKP 311
A ++ Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1668 AEQELEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQ 1726
Query: 312 HITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLP 371
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1727 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL-- 1784
Query: 372 GWKGMSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKL 428
++++ A + L+ +D A A R + + + E K +AL++++
Sbjct: 1785 ----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEA 1839
Query: 429 EEKRAFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVL 487
E +R A +A + R E QA Q + IEE + ++L RQ D LR
Sbjct: 1840 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1899
Query: 488 RVQEQ--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------Y 532
+V+E+ LK+ FE+ + K +E EL+ R+ D ++ A
Sbjct: 1900 QVEEEILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1958
Query: 533 ARLRGIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAV 585
R R E+ VQ AEEEA + + L VE LK ++ + + L A
Sbjct: 1959 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2018
Query: 586 EAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 635
EA + E A + L + + E+++ + + ARR A
Sbjct: 2019 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2068
Score = 56.6 bits (135), Expect = 8e-08
Identities = 87/400 (21%), Positives = 165/400 (41%), Gaps = 78/400 (19%)
Query: 164 EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 223
++ E E + +++R EEV R +Q K S+ + L+ LRQ++
Sbjct: 1352 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEA 1409
Query: 224 TLQAIAAQNAAVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 279
+QA A Q A + + +++ ++ +E Q EG L+ R +E
Sbjct: 1410 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEE 1462
Query: 280 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQ 338
A +A+EE E+++ +++ +++ V+L + VK + +AA+
Sbjct: 1463 AEAQKRQAQEEAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAR 1507
Query: 339 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAH 398
+ + + EL +QA + +R + EV + + A + + +L S A
Sbjct: 1508 EKQRALQALEELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFA 1564
Query: 399 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 458
+ QL R L E+ H+ +A +++ E R++ QAE +R E
Sbjct: 1565 EKTAQLERSLQEE------HVAVAQLREEAER---------------RAQQQAEAERARE 1603
Query: 459 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQ 518
E +E R QL+ A LR+Q +E+ + + L++ E + ++
Sbjct: 1604 EAERELE---RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEA 1647
Query: 519 EQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 558
E+ A R + EQAV+ +AE+E K QL
Sbjct: 1648 ER---------EARRRGKAEEQAVRQRELAEQELEKQRQL 1678
Score = 48.1 bits (113), Expect = 3e-05
Identities = 121/577 (20%), Positives = 227/577 (39%), Gaps = 84/577 (14%)
Query: 109 LKISSVSEVMKESKQPASQLQKQ--------KGDTPASATAGDTLSVPAPAVQPEESLKT 160
L++ E +E Q ++ QK KG SA A L++P P+ P
Sbjct: 985 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS--PAAPTLR 1042
Query: 161 DHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQT 220
E+ GK L + S S+I + ++ + + E+V + + + L++A Q
Sbjct: 1043 SELELTLGK----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQLKEA--QA 1095
Query: 221 ASVTLQAIAAQNAAVQAVNAHSNILKAAMD--NSEIAGEKKSAQ---------------W 263
TL + A A+++ + A + + D E+ G ++ + W
Sbjct: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155
Query: 264 RTVEGALKERRKAVDEAADALLKAKEEL-----------EKMKSVIENAKKK-EVAGAKP 311
R L ER +AV D + E+L + + + +++A+++ E A P
Sbjct: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
Query: 312 --HITAAEGKLHN---MIVDLDNVVKKVQAAQSEAK----VVSQYHELVVQARDDFKREL 362
A +L ++ +++ +KV+ Q AK + Y +V +K +L
Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT----YKAQL 1271
Query: 363 DSIT-----PEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQ 417
+ + P+V G + + + + +L +L + + I + R + E++ +Q
Sbjct: 1272 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1331
Query: 418 HITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ----LR 473
A E+++L E A ALE R +A K + R+A E + R Q R
Sbjct: 1332 Q--RAEERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1382
Query: 474 RQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDINTA 531
+AA + ++ + Q+L+ E + K + E + R +E++ L +
Sbjct: 1383 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1442
Query: 532 YARLRGIEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAVEA- 587
+ G E +Q+ A AEE + Q E L+ ++ S + L S V+A
Sbjct: 1443 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1502
Query: 588 IKANCSDNEFTQAL-TAAIPPESLTRGVYSEETLRAR 623
+A QAL + E R + E RAR
Sbjct: 1503 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1539
Score = 41.6 bits (96), Expect = 0.003
Identities = 77/357 (21%), Positives = 149/357 (41%), Gaps = 51/357 (14%)
Query: 167 EGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTL 225
E + ++EEA+ S+ + AARL Q +++ + +LA K L++ ++ T
Sbjct: 2247 EAEKMKQVAEEAARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302
Query: 226 QAIAAQNAAVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAAD 282
A+ Q A + D ++A E+ RT+E ER++ ++ +A+
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAE 2359
Query: 283 ALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQS 339
A E L+ + + A+ + A+ AE KLH + V VQ +
Sbjct: 2360 A-----ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2414
Query: 340 EAKVVSQYHELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDL 381
+ + E + +A + +RE + + E +L + + S L
Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474
Query: 382 ADKLSTDDLNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAV 438
++K S I +++QL ++ A+Q E+Q ++Q++E++R V
Sbjct: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLV 2527
Query: 439 AKALEHHRSEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 493
A E R + +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2528 ASMEEARRRQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2582
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 60.5 bits (145), Expect = 6e-09
Identities = 93/422 (22%), Positives = 168/422 (39%), Gaps = 68/422 (16%)
Query: 190 EVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAV----------- 238
++ RLAQ K ++E +ED LRQ V + +A + + +A
Sbjct: 1876 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1935
Query: 239 ----NAHSNILKAAMDNSEIAGEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKE 289
NA + E A +++ A + R E +++ A +EAA A E
Sbjct: 1936 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1995
Query: 290 ELEKMKSVIENAK----------------------KKEVAGAKPHITAAEGKLHNMIVDL 327
E+E++K+ +E A+ K+ A K H A + K + L
Sbjct: 1996 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2055
Query: 328 DNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-- 385
+ + EA+ + E +AR +RE +V + A++L
Sbjct: 2056 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV----------EEAERLKQ 2105
Query: 386 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----A 441
S ++ A A ++L +E AEQ+A + E+ L +K+A D+ + K A
Sbjct: 2106 SAEEQAQARAQAQAAAEKLRKE-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFA 2160
Query: 442 LEHHRSEIQAEQD----RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 497
+ R + Q EQ+ R E D +N + +L+R A T+ R +V+E+
Sbjct: 2161 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2220
Query: 498 FE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 556
+ + LS+ + E + R L DN + +++ + + +VA +EA +
Sbjct: 2221 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2280
Query: 557 QL 558
QL
Sbjct: 2281 QL 2282
Score = 60.1 bits (144), Expect = 7e-09
Identities = 106/527 (20%), Positives = 205/527 (38%), Gaps = 42/527 (7%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALS 175
E+ + +Q S L + +G+ A+ A + VQ E ++ E + +
Sbjct: 2050 ELQQTLQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVEEAERLKQSA 2107
Query: 176 EEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAV 235
EE + + + + E + A+QE + + E + ALRQ + + + A
Sbjct: 2108 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAE------QAALRQKQAADAEMEKHKKFAE 2161
Query: 236 QAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMK 295
Q + + + + + + E+ Q ++ L+ + EAA + +EEL ++
Sbjct: 2162 QTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2220
Query: 296 SVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQAR 355
+E E++ K I A L ++ D DN + +Q + K V++ + A
Sbjct: 2221 VQME-----ELSKLKARIEAENRAL--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2273
Query: 356 DDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHAHRRIDQLNRELAEQKAT 414
+ R L + E L + ++ L +K+ + + L A A + Q +ELA+++A
Sbjct: 2274 QEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQAR 2330
Query: 415 EKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRR 474
Q + +Q EE + F ++AE+ R++E +A ++R
Sbjct: 2331 RLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMS 2379
Query: 475 QAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQFRRLSQEQVDNFTLDINT 530
+A A + R Q +E+ + + +L+ QE +Q + ++Q D+ +
Sbjct: 2380 RAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQRQQSDHDAERLRE 2436
Query: 531 AYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVE 586
A A L ++ +Q A + EE + Q L E S + + +E
Sbjct: 2437 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2496
Query: 587 AIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARR 633
KA + A E R E R R A + ARR
Sbjct: 2497 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2543
Score = 58.5 bits (140), Expect = 2e-08
Identities = 111/530 (20%), Positives = 204/530 (38%), Gaps = 77/530 (14%)
Query: 153 QPEESLKTDHPEIGEGKPTPA--LSEEASSSSIRERPPEEV----------------AAR 194
Q E SL+ +H + + + ++A + RE E+ A
Sbjct: 1577 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1636
Query: 195 LAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEI 254
+AQQ+ Q + E + E R+ QA+ + E+
Sbjct: 1637 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------EL 1675
Query: 255 AGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKP 311
A ++ Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1676 AEQELEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQ 1734
Query: 312 HITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLP 371
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1735 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL-- 1792
Query: 372 GWKGMSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKL 428
++++ A + L+ +D A A R + + + E K +AL++++
Sbjct: 1793 ----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEA 1847
Query: 429 EEKRAFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVL 487
E +R A +A + R E QA Q + IEE + ++L RQ D LR
Sbjct: 1848 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1907
Query: 488 RVQEQ--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------Y 532
+V+E+ LK+ FE+ + K +E EL+ R+ D ++ A
Sbjct: 1908 QVEEEILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1966
Query: 533 ARLRGIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAV 585
R R E+ VQ AEEEA + + L VE LK ++ + + L A
Sbjct: 1967 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2026
Query: 586 EAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 635
EA + E A + L + + E+++ + + ARR A
Sbjct: 2027 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2076
Score = 56.6 bits (135), Expect = 8e-08
Identities = 87/400 (21%), Positives = 165/400 (41%), Gaps = 78/400 (19%)
Query: 164 EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 223
++ E E + +++R EEV R +Q K S+ + L+ LRQ++
Sbjct: 1360 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEA 1417
Query: 224 TLQAIAAQNAAVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 279
+QA A Q A + + +++ ++ +E Q EG L+ R +E
Sbjct: 1418 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEE 1470
Query: 280 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQ 338
A +A+EE E+++ +++ +++ V+L + VK + +AA+
Sbjct: 1471 AEAQKRQAQEEAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAR 1515
Query: 339 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAH 398
+ + + EL +QA + +R + EV + + A + + +L S A
Sbjct: 1516 EKQRALQALEELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFA 1572
Query: 399 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 458
+ QL R L E+ H+ +A +++ E R++ QAE +R E
Sbjct: 1573 EKTAQLERSLQEE------HVAVAQLREEAER---------------RAQQQAEAERARE 1611
Query: 459 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQ 518
E +E R QL+ A LR+Q +E+ + + L++ E + ++
Sbjct: 1612 EAERELE---RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEA 1655
Query: 519 EQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 558
E+ A R + EQAV+ +AE+E K QL
Sbjct: 1656 ER---------EARRRGKAEEQAVRQRELAEQELEKQRQL 1686
Score = 48.1 bits (113), Expect = 3e-05
Identities = 121/577 (20%), Positives = 227/577 (39%), Gaps = 84/577 (14%)
Query: 109 LKISSVSEVMKESKQPASQLQKQ--------KGDTPASATAGDTLSVPAPAVQPEESLKT 160
L++ E +E Q ++ QK KG SA A L++P P+ P
Sbjct: 993 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS--PAAPTLR 1050
Query: 161 DHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQT 220
E+ GK L + S S+I + ++ + + E+V + + + L++A Q
Sbjct: 1051 SELELTLGK----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQLKEA--QA 1103
Query: 221 ASVTLQAIAAQNAAVQAVNAHSNILKAAMD--NSEIAGEKKSAQ---------------W 263
TL + A A+++ + A + + D E+ G ++ + W
Sbjct: 1104 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1163
Query: 264 RTVEGALKERRKAVDEAADALLKAKEEL-----------EKMKSVIENAKKK-EVAGAKP 311
R L ER +AV D + E+L + + + +++A+++ E A P
Sbjct: 1164 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1223
Query: 312 --HITAAEGKLHN---MIVDLDNVVKKVQAAQSEAK----VVSQYHELVVQARDDFKREL 362
A +L ++ +++ +KV+ Q AK + Y +V +K +L
Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT----YKAQL 1279
Query: 363 DSIT-----PEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQ 417
+ + P+V G + + + + +L +L + + I + R + E++ +Q
Sbjct: 1280 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1339
Query: 418 HITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ----LR 473
A E+++L E A ALE R +A K + R+A E + R Q R
Sbjct: 1340 Q--RAEERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1390
Query: 474 RQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDINTA 531
+AA + ++ + Q+L+ E + K + E + R +E++ L +
Sbjct: 1391 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1450
Query: 532 YARLRGIEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAVEA- 587
+ G E +Q+ A AEE + Q E L+ ++ S + L S V+A
Sbjct: 1451 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1510
Query: 588 IKANCSDNEFTQAL-TAAIPPESLTRGVYSEETLRAR 623
+A QAL + E R + E RAR
Sbjct: 1511 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1547
Score = 41.6 bits (96), Expect = 0.003
Identities = 77/357 (21%), Positives = 149/357 (41%), Gaps = 51/357 (14%)
Query: 167 EGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTL 225
E + ++EEA+ S+ + AARL Q +++ + +LA K L++ ++ T
Sbjct: 2255 EAEKMKQVAEEAARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310
Query: 226 QAIAAQNAAVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAAD 282
A+ Q A + D ++A E+ RT+E ER++ ++ +A+
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAE 2367
Query: 283 ALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQS 339
A E L+ + + A+ + A+ AE KLH + V VQ +
Sbjct: 2368 A-----ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2422
Query: 340 EAKVVSQYHELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDL 381
+ + E + +A + +RE + + E +L + + S L
Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2482
Query: 382 ADKLSTDDLNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAV 438
++K S I +++QL ++ A+Q E+Q ++Q++E++R V
Sbjct: 2483 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLV 2535
Query: 439 AKALEHHRSEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 493
A E R + +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2536 ASMEEARRRQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2590
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 60.5 bits (145), Expect = 6e-09
Identities = 93/422 (22%), Positives = 168/422 (39%), Gaps = 68/422 (16%)
Query: 190 EVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAV----------- 238
++ RLAQ K ++E +ED LRQ V + +A + + +A
Sbjct: 1917 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1976
Query: 239 ----NAHSNILKAAMDNSEIAGEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKE 289
NA + E A +++ A + R E +++ A +EAA A E
Sbjct: 1977 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2036
Query: 290 ELEKMKSVIENAK----------------------KKEVAGAKPHITAAEGKLHNMIVDL 327
E+E++K+ +E A+ K+ A K H A + K + L
Sbjct: 2037 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2096
Query: 328 DNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-- 385
+ + EA+ + E +AR +RE +V + A++L
Sbjct: 2097 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV----------EEAERLKQ 2146
Query: 386 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----A 441
S ++ A A ++L +E AEQ+A + E+ L +K+A D+ + K A
Sbjct: 2147 SAEEQAQARAQAQAAAEKLRKE-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFA 2201
Query: 442 LEHHRSEIQAEQD----RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 497
+ R + Q EQ+ R E D +N + +L+R A T+ R +V+E+
Sbjct: 2202 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2261
Query: 498 FE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 556
+ + LS+ + E + R L DN + +++ + + +VA +EA +
Sbjct: 2262 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2321
Query: 557 QL 558
QL
Sbjct: 2322 QL 2323
Score = 60.1 bits (144), Expect = 7e-09
Identities = 106/527 (20%), Positives = 205/527 (38%), Gaps = 42/527 (7%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALS 175
E+ + +Q S L + +G+ A+ A + VQ E ++ E + +
Sbjct: 2091 ELQQTLQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVEEAERLKQSA 2148
Query: 176 EEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAV 235
EE + + + + E + A+QE + + E + ALRQ + + + A
Sbjct: 2149 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAE------QAALRQKQAADAEMEKHKKFAE 2202
Query: 236 QAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMK 295
Q + + + + + + E+ Q ++ L+ + EAA + +EEL ++
Sbjct: 2203 QTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2261
Query: 296 SVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQAR 355
+E E++ K I A L ++ D DN + +Q + K V++ + A
Sbjct: 2262 VQME-----ELSKLKARIEAENRAL--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2314
Query: 356 DDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHAHRRIDQLNRELAEQKAT 414
+ R L + E L + ++ L +K+ + + L A A + Q +ELA+++A
Sbjct: 2315 QEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQAR 2371
Query: 415 EKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRR 474
Q + +Q EE + F ++AE+ R++E +A ++R
Sbjct: 2372 RLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMS 2420
Query: 475 QAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQFRRLSQEQVDNFTLDINT 530
+A A + R Q +E+ + + +L+ QE +Q + ++Q D+ +
Sbjct: 2421 RAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477
Query: 531 AYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVE 586
A A L ++ +Q A + EE + Q L E S + + +E
Sbjct: 2478 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2537
Query: 587 AIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARR 633
KA + A E R E R R A + ARR
Sbjct: 2538 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2584
Score = 58.5 bits (140), Expect = 2e-08
Identities = 111/530 (20%), Positives = 204/530 (38%), Gaps = 77/530 (14%)
Query: 153 QPEESLKTDHPEIGEGKPTPA--LSEEASSSSIRERPPEEV----------------AAR 194
Q E SL+ +H + + + ++A + RE E+ A
Sbjct: 1618 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1677
Query: 195 LAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEI 254
+AQQ+ Q + E + E R+ QA+ + E+
Sbjct: 1678 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------EL 1716
Query: 255 AGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKP 311
A ++ Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1717 AEQELEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQ 1775
Query: 312 HITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLP 371
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1776 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL-- 1833
Query: 372 GWKGMSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKL 428
++++ A + L+ +D A A R + + + E K +AL++++
Sbjct: 1834 ----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEA 1888
Query: 429 EEKRAFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVL 487
E +R A +A + R E QA Q + IEE + ++L RQ D LR
Sbjct: 1889 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1948
Query: 488 RVQEQ--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------Y 532
+V+E+ LK+ FE+ + K +E EL+ R+ D ++ A
Sbjct: 1949 QVEEEILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2007
Query: 533 ARLRGIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAV 585
R R E+ VQ AEEEA + + L VE LK ++ + + L A
Sbjct: 2008 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2067
Query: 586 EAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 635
EA + E A + L + + E+++ + + ARR A
Sbjct: 2068 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2117
Score = 56.6 bits (135), Expect = 8e-08
Identities = 87/400 (21%), Positives = 165/400 (41%), Gaps = 78/400 (19%)
Query: 164 EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 223
++ E E + +++R EEV R +Q K S+ + L+ LRQ++
Sbjct: 1401 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEA 1458
Query: 224 TLQAIAAQNAAVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 279
+QA A Q A + + +++ ++ +E Q EG L+ R +E
Sbjct: 1459 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEE 1511
Query: 280 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQ 338
A +A+EE E+++ +++ +++ V+L + VK + +AA+
Sbjct: 1512 AEAQKRQAQEEAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAR 1556
Query: 339 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAH 398
+ + + EL +QA + +R + EV + + A + + +L S A
Sbjct: 1557 EKQRALQALEELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFA 1613
Query: 399 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 458
+ QL R L E+ H+ +A +++ E R++ QAE +R E
Sbjct: 1614 EKTAQLERSLQEE------HVAVAQLREEAER---------------RAQQQAEAERARE 1652
Query: 459 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQ 518
E +E R QL+ A LR+Q +E+ + + L++ E + ++
Sbjct: 1653 EAERELE---RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEA 1696
Query: 519 EQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 558
E+ A R + EQAV+ +AE+E K QL
Sbjct: 1697 ER---------EARRRGKAEEQAVRQRELAEQELEKQRQL 1727
Score = 48.1 bits (113), Expect = 3e-05
Identities = 121/577 (20%), Positives = 227/577 (39%), Gaps = 84/577 (14%)
Query: 109 LKISSVSEVMKESKQPASQLQKQ--------KGDTPASATAGDTLSVPAPAVQPEESLKT 160
L++ E +E Q ++ QK KG SA A L++P P+ P
Sbjct: 1034 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS--PAAPTLR 1091
Query: 161 DHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQT 220
E+ GK L + S S+I + ++ + + E+V + + + L++A Q
Sbjct: 1092 SELELTLGK----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQLKEA--QA 1144
Query: 221 ASVTLQAIAAQNAAVQAVNAHSNILKAAMD--NSEIAGEKKSAQ---------------W 263
TL + A A+++ + A + + D E+ G ++ + W
Sbjct: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204
Query: 264 RTVEGALKERRKAVDEAADALLKAKEEL-----------EKMKSVIENAKKK-EVAGAKP 311
R L ER +AV D + E+L + + + +++A+++ E A P
Sbjct: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
Query: 312 --HITAAEGKLHN---MIVDLDNVVKKVQAAQSEAK----VVSQYHELVVQARDDFKREL 362
A +L ++ +++ +KV+ Q AK + Y +V +K +L
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT----YKAQL 1320
Query: 363 DSIT-----PEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQ 417
+ + P+V G + + + + +L +L + + I + R + E++ +Q
Sbjct: 1321 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1380
Query: 418 HITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ----LR 473
A E+++L E A ALE R +A K + R+A E + R Q R
Sbjct: 1381 Q--RAEERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1431
Query: 474 RQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDINTA 531
+AA + ++ + Q+L+ E + K + E + R +E++ L +
Sbjct: 1432 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1491
Query: 532 YARLRGIEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAVEA- 587
+ G E +Q+ A AEE + Q E L+ ++ S + L S V+A
Sbjct: 1492 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1551
Query: 588 IKANCSDNEFTQAL-TAAIPPESLTRGVYSEETLRAR 623
+A QAL + E R + E RAR
Sbjct: 1552 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1588
Score = 41.6 bits (96), Expect = 0.003
Identities = 77/357 (21%), Positives = 149/357 (41%), Gaps = 51/357 (14%)
Query: 167 EGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTL 225
E + ++EEA+ S+ + AARL Q +++ + +LA K L++ ++ T
Sbjct: 2296 EAEKMKQVAEEAARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351
Query: 226 QAIAAQNAAVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAAD 282
A+ Q A + D ++A E+ RT+E ER++ ++ +A+
Sbjct: 2352 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAE 2408
Query: 283 ALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQS 339
A E L+ + + A+ + A+ AE KLH + V VQ +
Sbjct: 2409 A-----ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2463
Query: 340 EAKVVSQYHELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDL 381
+ + E + +A + +RE + + E +L + + S L
Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2523
Query: 382 ADKLSTDDLNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAV 438
++K S I +++QL ++ A+Q E+Q ++Q++E++R V
Sbjct: 2524 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLV 2576
Query: 439 AKALEHHRSEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 493
A E R + +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2577 ASMEEARRRQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2631
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 59.7 bits (143), Expect = 1e-08
Identities = 98/493 (19%), Positives = 209/493 (42%), Gaps = 64/493 (12%)
Query: 110 KISSVSEVMKESKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGK 169
++S E + K +LQ++K D L A +++ + K D G +
Sbjct: 1466 ELSQAHEEAQREKLQREKLQREK----------DMLLAEAFSLKQQLEEK-DMDIAGFTQ 1514
Query: 170 PTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA 229
+L E S +E E A++ +Q + + K++ + L++ + +
Sbjct: 1515 KVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLR 1574
Query: 230 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 289
+ + HS +++ + E A + + + +E L+E E +L+ K
Sbjct: 1575 LEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEY----EDKQKVLREKR 1630
Query: 290 ELE-KMKSVIENAKKKEVAGAK---PHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVS 345
ELE K+ ++ + +++ K + + L + + LD++ + + A++ +
Sbjct: 1631 ELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKN 1690
Query: 346 QYHE------LVVQARDDFKRELDSITPEVLPGWKGMSV------------SDLADKLST 387
Q E V+AR + E++ + ++ K + +++ ++L
Sbjct: 1691 QLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEE 1750
Query: 388 D--DLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHH 445
D D+N L+ + Q +R+LA+ + Q EKQ+L+EK + + LE
Sbjct: 1751 DQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQS 1810
Query: 446 R--SEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLS 503
+ + Q+ KI E+ +E E RTQ++R + L L+ ++L E +Q ++
Sbjct: 1811 MVDKSLVSRQEAKIRELETRLEFE-RTQVKR-----LESLASRLKENMEKLTEERDQRIA 1864
Query: 504 EKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEA-RKAHQLWLSV 562
+ E+E Q +RL ++ LR ++ + A E EA RK H+L + +
Sbjct: 1865 AENREKE-QNKRLQRQ---------------LRDTKEEMGELARKEAEASRKKHELEMDL 1908
Query: 563 EALKYSMKTSSAE 575
E+L+ + ++ A+
Sbjct: 1909 ESLEAANQSLQAD 1921
Score = 47.8 bits (112), Expect = 4e-05
Identities = 77/368 (20%), Positives = 147/368 (39%), Gaps = 59/368 (16%)
Query: 177 EASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQ 236
E +S ER E A++L E E+++ E K L+ A+ Q ++
Sbjct: 1293 ELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQ--------TQYDALKKQMEVME 1344
Query: 237 AVNAHSNILKAAMDNSEIAGEKKSAQWR-TVEGALKE----RRKAVDEAADAL---LKAK 288
+ +++AA N E+ + +WR E A++E +++ E D L + K
Sbjct: 1345 MEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNK 1404
Query: 289 EELEK-----------MKSVIENAKKK------EVAGAKPHITAAEGKLHNMIVDLDNVV 331
+LE+ + ++ KKK E+ K H+ + + H +L+
Sbjct: 1405 RQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNH----ELEKKQ 1460
Query: 332 KKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLN 391
++ + S+A +Q +L R+ +RE D + E L +L D++
Sbjct: 1461 RRFDSELSQAHEEAQREKL---QREKLQREKDMLLAEAF---------SLKQQLEEKDMD 1508
Query: 392 SLIAHAHRRIDQLNRELAEQKATE-KQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQ 450
IA +++ L EL + + E K +LA K++L + A + L+ IQ
Sbjct: 1509 --IAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQ 1566
Query: 451 AEQDRKI------EEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSE 504
+ K+ E +R EM ++ A + L+ E +L+ E+E
Sbjct: 1567 MLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEAR-QSCQKKLKQMEVQLEEEYEDKQKV 1625
Query: 505 KLSEQELQ 512
++EL+
Sbjct: 1626 LREKRELE 1633
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 59.7 bits (143), Expect = 1e-08
Identities = 98/493 (19%), Positives = 209/493 (42%), Gaps = 64/493 (12%)
Query: 110 KISSVSEVMKESKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGK 169
++S E + K +LQ++K D L A +++ + K D G +
Sbjct: 1466 ELSQAHEEAQREKLQREKLQREK----------DMLLAEAFSLKQQLEEK-DMDIAGFTQ 1514
Query: 170 PTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA 229
+L E S +E E A++ +Q + + K++ + L++ + +
Sbjct: 1515 KVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLR 1574
Query: 230 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 289
+ + HS +++ + E A + + + +E L+E E +L+ K
Sbjct: 1575 LEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEY----EDKQKVLREKR 1630
Query: 290 ELE-KMKSVIENAKKKEVAGAK---PHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVS 345
ELE K+ ++ + +++ K + + L + + LD++ + + A++ +
Sbjct: 1631 ELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKN 1690
Query: 346 QYHE------LVVQARDDFKRELDSITPEVLPGWKGMSV------------SDLADKLST 387
Q E V+AR + E++ + ++ K + +++ ++L
Sbjct: 1691 QLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEE 1750
Query: 388 D--DLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHH 445
D D+N L+ + Q +R+LA+ + Q EKQ+L+EK + + LE
Sbjct: 1751 DQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQS 1810
Query: 446 R--SEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLS 503
+ + Q+ KI E+ +E E RTQ++R + L L+ ++L E +Q ++
Sbjct: 1811 MVDKSLVSRQEAKIRELETRLEFE-RTQVKR-----LESLASRLKENMEKLTEERDQRIA 1864
Query: 504 EKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEA-RKAHQLWLSV 562
+ E+E Q +RL ++ LR ++ + A E EA RK H+L + +
Sbjct: 1865 AENREKE-QNKRLQRQ---------------LRDTKEEMGELARKEAEASRKKHELEMDL 1908
Query: 563 EALKYSMKTSSAE 575
E+L+ + ++ A+
Sbjct: 1909 ESLEAANQSLQAD 1921
Score = 47.8 bits (112), Expect = 4e-05
Identities = 77/368 (20%), Positives = 147/368 (39%), Gaps = 59/368 (16%)
Query: 177 EASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQ 236
E +S ER E A++L E E+++ E K L+ A+ Q ++
Sbjct: 1293 ELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQ--------TQYDALKKQMEVME 1344
Query: 237 AVNAHSNILKAAMDNSEIAGEKKSAQWR-TVEGALKE----RRKAVDEAADAL---LKAK 288
+ +++AA N E+ + +WR E A++E +++ E D L + K
Sbjct: 1345 MEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNK 1404
Query: 289 EELEK-----------MKSVIENAKKK------EVAGAKPHITAAEGKLHNMIVDLDNVV 331
+LE+ + ++ KKK E+ K H+ + + H +L+
Sbjct: 1405 RQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNH----ELEKKQ 1460
Query: 332 KKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLN 391
++ + S+A +Q +L R+ +RE D + E L +L D++
Sbjct: 1461 RRFDSELSQAHEEAQREKL---QREKLQREKDMLLAEAF---------SLKQQLEEKDMD 1508
Query: 392 SLIAHAHRRIDQLNRELAEQKATE-KQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQ 450
IA +++ L EL + + E K +LA K++L + A + L+ IQ
Sbjct: 1509 --IAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQ 1566
Query: 451 AEQDRKI------EEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSE 504
+ K+ E +R EM ++ A + L+ E +L+ E+E
Sbjct: 1567 MLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEAR-QSCQKKLKQMEVQLEEEYEDKQKV 1625
Query: 505 KLSEQELQ 512
++EL+
Sbjct: 1626 LREKRELE 1633
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 59.3 bits (142), Expect = 1e-08
Identities = 101/491 (20%), Positives = 207/491 (42%), Gaps = 57/491 (11%)
Query: 102 KSIQSGPLKISSVSEVMKESKQPASQLQKQKGDTPASATAGDTL---SVPAPAVQPEESL 158
K ++ +I+ + E + K ++ +KQK D A T ++ A Q E
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRT 1170
Query: 159 KTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALR 218
K + E+ E K AL EE + A++ ++ +E L++ LE A R
Sbjct: 1171 KREQ-EVAELKK--ALEEETKNHE----------AQIQDMRQRHATALEELSEQLEQAKR 1217
Query: 219 QTASV--TLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKA 276
A++ Q + N + + +L+ SE +K AQ + + + E +
Sbjct: 1218 FKANLEKNKQGLETDN---KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRL 1274
Query: 277 VDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLD-------N 329
E A+ K + EL+ + +++E A+KK + AK + E +L + L N
Sbjct: 1275 RVELAEKASKLQNELDNVSTLLEEAEKKGIKFAK-DAASLESQLQDTQELLQEETRQKLN 1333
Query: 330 VVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGM--------SVSDL 381
+ +++ + E + + E +AR + ++++ ++ ++ K + S+ +
Sbjct: 1334 LSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEA 1393
Query: 382 ADKLSTD--DLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQK-----LEEK-RA 433
KL D L+ + D+L + + E +T+ L+ Q+ LE+K +
Sbjct: 1394 KKKLLKDAEALSQRLEEKALAYDKLEK-TKNRLQQELDDLTVDLDHQRQVASNLEKKQKK 1452
Query: 434 FDSAVAK--------ALEHHRSEIQA-EQDRKIEEVRDAMEN--EMRTQLRRQAAAHTDH 482
FD +A+ A E R+E +A E++ K + A+E E + + RQ
Sbjct: 1453 FDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRAD 1512
Query: 483 LRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAV 542
+ D++ ++ K+ E S++ EQ+++ R E++++ A RL QA+
Sbjct: 1513 MEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAM 1572
Query: 543 QSHAVAEEEAR 553
++ + + R
Sbjct: 1573 KAQFERDLQTR 1583
Score = 57.8 bits (138), Expect = 4e-08
Identities = 97/433 (22%), Positives = 169/433 (39%), Gaps = 73/433 (16%)
Query: 189 EEVAARLAQQEKQE-QVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKA 247
EE ++ Q EK++ Q I+ L + L++ + L+ + A+ + IL
Sbjct: 934 EEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAE---AKIKKMEEEILLL 990
Query: 248 AMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVA 307
NS+ EKK + R E + + + +E A L K + + E M S +E KKE
Sbjct: 991 EDQNSKFIKEKKLMEDRIAECSSQLAEE--EEKAKNLAKIRNKQEVMISDLEERLKKEEK 1048
Query: 308 GAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQ---ARDDFK----- 359
+ + A+ KL DL + + ++QA E K+ E +Q AR D +
Sbjct: 1049 -TRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN 1107
Query: 360 ------RELDSITPEVLPGWKGMSVS-DLADKLSTDDLNSLIAHAHRRIDQLNRELAEQK 412
REL + E+ ++ S + A+K D L A D L+ A+Q+
Sbjct: 1108 NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE 1167
Query: 413 ATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVR----------- 461
K+ +A K+ LEE+ A + + + E ++E+ +
Sbjct: 1168 LRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQ 1227
Query: 462 ----DAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQN------LSEKLSEQEL 511
D E ++ +Q A ++H R L Q QEL ++ + L+EK S+ +
Sbjct: 1228 GLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN 1287
Query: 512 QFRRLS---------------------------QEQVDNFTLDINTAYARLRGIEQ---A 541
+ +S QE + T +R+R +E+ +
Sbjct: 1288 ELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNS 1347
Query: 542 VQSHAVAEEEARK 554
+Q EEEARK
Sbjct: 1348 LQEQQEEEEEARK 1360
Score = 48.9 bits (115), Expect = 2e-05
Identities = 126/598 (21%), Positives = 230/598 (38%), Gaps = 137/598 (22%)
Query: 101 KKSIQSGPLKISSVSEVMKESKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEE---S 157
KK + I S+ E K+ + A L ++ + A A D L +Q E +
Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE---KALAYDKLEKTKNRLQQELDDLT 1433
Query: 158 LKTDHP-------EIGEGKPTPALSEEASSSS--IRERPPEEVAARLAQQEKQEQVKIES 208
+ DH E + K L+EE S S+ ER E AR +++ K S
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAR------EKETKALS 1487
Query: 209 LAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAA--MDNSEIAGEKKSAQWRTV 266
LA++LE+AL Q + +++ ++ K ++ S+ A E++ + RT
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1547
Query: 267 EGALKERRKAVDEAADALLKAKEELEKMKSVIE---------NAKKK------------E 305
L++ +A + DA L+ + ++ MK+ E N +KK E
Sbjct: 1548 LEELEDELQATE---DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAE 1604
Query: 306 VAGAKPHITAAEGKLHNMIVDLDNVVKKVQAA-QSEAKVVSQYHELVVQARDDFKRELDS 364
+ + A M +DL ++ +++AA ++ +V+ Q +L Q +D ++REL+
Sbjct: 1605 LEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKD-YQRELEE 1663
Query: 365 ITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALE 424
+ S D++ A+ K +EK+ +L E
Sbjct: 1664 A------------------RASRDEI-----------------FAQSKESEKKLKSLEAE 1688
Query: 425 KQKLEEKRAFDSAVAKALEHHRSEIQ------------------------AEQDRKIEEV 460
+L+E+ A + E R E+ A+ + ++EE
Sbjct: 1689 ILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEE 1748
Query: 461 RDAME-------------NEMRTQL--RRQAAAHTDHLRDVLRVQEQELKSEFEQ----- 500
+ ME + + +L R AA +D+ R L Q +ELK++ ++
Sbjct: 1749 QSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV 1808
Query: 501 --NLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQS-HAVAEEEARKAHQ 557
+S E + +L +EQ++ + A +R E+ ++ E+E R A Q
Sbjct: 1809 KSKFKATISALEAKIGQL-EEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQ 1867
Query: 558 LWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPP-ESLTRGV 614
+E MK + + EA +AN S + + L A E L+R V
Sbjct: 1868 YKEQMEKANARMKQLKRQLEE----AEEEATRANASRRKLQRELDDATEANEGLSREV 1921
Score = 47.0 bits (110), Expect = 6e-05
Identities = 107/569 (18%), Positives = 216/569 (37%), Gaps = 59/569 (10%)
Query: 73 ESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKESKQPASQLQKQ- 131
E+ K + K+ + V + + +Q K+S + E + AS+LQ +
Sbjct: 1230 ETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNEL 1289
Query: 132 --------KGDTPASATAGDTLSVPAPAVQPEESLKTD-HPEIGEGKPTPALSEEASSSS 182
+ + A D S+ + +E L+ + ++ L EE +S
Sbjct: 1290 DNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQ 1349
Query: 183 IRERPPEEVAARLAQQEKQEQVKIESLAKSLED-------------ALRQTASVTLQAIA 229
++ EE L +Q Q ++ K ++D L + A Q +
Sbjct: 1350 EQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE 1409
Query: 230 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE--AADALLKA 287
+ A + N L+ +D+ + + + R V L++++K D+ A + + A
Sbjct: 1410 EKALAYDKLEKTKNRLQQELDDLTVDLDHQ----RQVASNLEKKQKKFDQLLAEEKSISA 1465
Query: 288 K--EELEKMKSVIENAKKKEVAGAKPHITAAEGK-------------LHNMIVDLDNVVK 332
+ EE ++ ++ + K ++ A+ A E K + +++ D+V K
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGK 1525
Query: 333 KVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLP---GWKGMSVSDLADKLSTDD 389
V + + + Q E + ++ + EL + L + M D + D+
Sbjct: 1526 NVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDE 1585
Query: 390 LNSLIAHAHRRIDQLNREL-AEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSE 448
N R + + REL AE + KQ K+K+E A +A R E
Sbjct: 1586 QNE---EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDE 1642
Query: 449 IQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQ--NLSEKL 506
+ +Q RK++ + E+ +A A D + + E++LKS + L E+L
Sbjct: 1643 V-IKQLRKLQAQMKDYQRELE-----EARASRDEIFAQSKESEKKLKSLEAEILQLQEEL 1696
Query: 507 SEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALK 566
+ E R QE+ + N+A + +++ + A + + + ++E L
Sbjct: 1697 ASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLN 1756
Query: 567 YSMKTSSAETPTIPLGSAVEAIKANCSDN 595
+ ++ + T+ A E A SDN
Sbjct: 1757 DRFRKTTLQVDTLNAELAAERSAAQKSDN 1785
Score = 32.0 bits (71), Expect = 2.2
Identities = 53/252 (21%), Positives = 105/252 (41%), Gaps = 34/252 (13%)
Query: 402 DQLNRELAEQKATEKQHITLALEKQKLEE-KRAFDSAVAKALEHHRSEIQAEQDRK---- 456
+QL E E+ LA +KQ+LEE +S V + E R++I + +K
Sbjct: 894 EQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEE--EEERNQILQNEKKKMQAH 951
Query: 457 IEEVRDAMENEMRTQLRRQAAAHTDHLR------DVLRVQEQELKSEFEQNLSE-KLSEQ 509
I+++ + ++ E + + Q T + ++L +++Q K E+ L E +++E
Sbjct: 952 IQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011
Query: 510 ELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSM 569
Q +E+ N N + +E+ ++ +E KA + K
Sbjct: 1012 SSQLAE-EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKR--------KLDG 1062
Query: 570 KTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRAR--FYAV 627
+T+ + L + ++ +K + E + L A L RG +ETL V
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKE--EELQGA-----LARG--DDETLHKNNALKVV 1113
Query: 628 QKLARRVAMIDE 639
++L ++A + E
Sbjct: 1114 RELQAQIAELQE 1125
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 58.5 bits (140), Expect = 2e-08
Identities = 91/428 (21%), Positives = 188/428 (43%), Gaps = 41/428 (9%)
Query: 143 DTLSVPAPAV-QPEESLKTDHPEIGEGKPTPALSEEASSSSIRERPP-----EEVAARLA 196
DT+S A+ Q E +K E+ + + + + ++E+ + L
Sbjct: 1968 DTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELL 2027
Query: 197 QQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAG 256
+ + Q K++SL K + AL T IA N + + S L+A + S+
Sbjct: 2028 KDKTHLQEKLQSLEKDSQ-ALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDY-- 2084
Query: 257 EKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAA 316
EK + + +E AL E+ E A L +EE+ +++ IE + + A K + A
Sbjct: 2085 EKLNVS-KALEAALVEK----GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIA 2139
Query: 317 EGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGM 376
E KL + D++ KV+ + E ++ + ELV+ ++ K E++++ ++ + +
Sbjct: 2140 E-KLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSL 2198
Query: 377 SVSDL---ADKLSTDDLNSLIAHAHRRIDQLNRELAEQKA--TEKQHITLALEKQK---- 427
V +L + ++L I ++ +L++ L+ K+ EK+ + ++++
Sbjct: 2199 KVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAV 2258
Query: 428 ---LEEKRAFDSAVAKALEHHRSEIQAEQ--DRKIEEVRDAMENEMRTQLRRQAAAHTDH 482
+ + + AVA EQ D IEE E+++R + + A
Sbjct: 2259 EMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEE-----EHQLRNSIEKLRARLEAD 2313
Query: 483 LRDVLRVQEQELKSEFEQNLSE---KLSEQELQFRRLSQE----QVDNFTLDINTAYARL 535
+ L V +Q +SE +L + + E+EL+ R +QE + +N ++ T A++
Sbjct: 2314 EKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKI 2373
Query: 536 RGIEQAVQ 543
G+ Q+++
Sbjct: 2374 EGMTQSLR 2381
Score = 47.0 bits (110), Expect = 6e-05
Identities = 81/409 (19%), Positives = 185/409 (45%), Gaps = 44/409 (10%)
Query: 194 RLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSE 253
++ ++EK+ Q ++ +S + ++ + ++A Q QA N H N+L+A +D
Sbjct: 388 KIKEKEKEFQEELSRQQRSFQTLDQEC--IQMKARLTQELQ-QAKNMH-NVLQAELD--- 440
Query: 254 IAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHI 313
K ++ + +E L+E ++ + A A ++ + +++ +E KK+ K H
Sbjct: 441 ----KLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNL-LKSHS 495
Query: 314 TAAEGKLHNMIVDLDNVVKKVQAAQS-----EAKVVSQYHELVVQARDDFKRELDSITPE 368
++ ++ +L N+ + + +Q+ +AK SQ ++ ++ ++ +S+T E
Sbjct: 496 EQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQ-ETMLRDLQEKINQQENSLTLE 554
Query: 369 VLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHIT-LALEKQK 427
L ++V+DL + D L+ I+QLN +L++ + K ++ L L+K++
Sbjct: 555 KLK----LAVADLEKQ--RDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKE 608
Query: 428 LEEKR-------AFDSAVAKALEHHRSEIQAEQDR--------KIEEVRDAMENEMRTQL 472
EE + + S K L SE + Q + K ++++ NE L
Sbjct: 609 YEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTL 668
Query: 473 RRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFR-RLSQEQVDNFTLDINTA 531
+ +R++ V + + Q L+ +Q+ +F + Q++++N L +
Sbjct: 669 EMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQL 728
Query: 532 YARLRGIEQAVQ--SHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPT 578
++ +E +Q S+ + +++ R L E+L+ +K+ A T
Sbjct: 729 TGQVEDLEHKLQLLSNEIMDKD-RCYQDLHAEYESLRDLLKSKDASLVT 776
Score = 34.3 bits (77), Expect = 0.43
Identities = 62/356 (17%), Positives = 136/356 (38%), Gaps = 72/356 (20%)
Query: 245 LKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKK 304
L+ +D + +++ Q ++E AL+++++ V+ K E +++ + E+ +K
Sbjct: 23 LEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKT 82
Query: 305 ------EVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDF 358
E+ + + EG+L++ ++ + ++++ +SE + Q + + +
Sbjct: 83 KQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPC 142
Query: 359 KRELDSITPEVLPG--WKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEK 416
T + P + G DL +K N+E+ E+K E
Sbjct: 143 NTPQKIFTTPLTPSQYYSGSKYEDLKEKY-------------------NKEVEERKRLEA 183
Query: 417 QHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQA 476
+ AL+ +K + + + + H++ ++ + N RT +RR
Sbjct: 184 E--VKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDF 241
Query: 477 AAH-------------------------------TDHLRDVLRVQEQELKSEFEQNLSEK 505
+A + HL D L+ Q QEL++ K
Sbjct: 242 SASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRN--------K 293
Query: 506 LSEQELQFRRLSQE---QVDNF-TLDINTAYARLRGIEQAVQSHAVAEEEARKAHQ 557
++E EL+ + +E QV+ F L + A++ IE+ + +E R Q
Sbjct: 294 INELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQ 349
Score = 34.3 bits (77), Expect = 0.43
Identities = 56/330 (16%), Positives = 137/330 (41%), Gaps = 49/330 (14%)
Query: 196 AQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQA--------VNAHSNILKA 247
++Q+ +E +E+ K+++ L Q+ + + + A+N + + +N N L
Sbjct: 495 SEQKAREVCHLEAELKNIKQCLNQSQNFA-EEMKAKNTSQETMLRDLQEKINQQENSL-- 551
Query: 248 AMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKK--KE 305
++ ++A Q + LK+R +++ D L K ++E + + S +E KK +E
Sbjct: 552 TLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEE 611
Query: 306 VAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSI 365
+ K + + + ++ +++ + +Q+ + + + ++ ++ R L+
Sbjct: 612 LKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLE-- 669
Query: 366 TPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEK 425
+ ++L+ I + H +D + E+ QK L
Sbjct: 670 -------------------MDRENLSVEIRNLHNVLDSKSVEVETQK----------LAY 700
Query: 426 QKLEEKRAF-DSAVAKALEHH--RSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDH 482
+L++K F D K +E+ ++ Q +E + NE+ + R H ++
Sbjct: 701 MELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEY 760
Query: 483 --LRDVLRVQEQELKSEFEQNLSEKLSEQE 510
LRD+L+ ++ L + + S +Q+
Sbjct: 761 ESLRDLLKSKDASLVTNEDHQRSLLAFDQQ 790
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 58.5 bits (140), Expect = 2e-08
Identities = 58/250 (23%), Positives = 109/250 (43%), Gaps = 28/250 (11%)
Query: 291 LEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHEL 350
+EK + +EN ++KE A E K L+ V K + + V Q E
Sbjct: 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRR----LEEVKLK---REERLRKVLQARER 587
Query: 351 VVQARDDFKRELDSITPEVLPGWKGMSVSDLAD-----KLSTDDLNSLIAHAHRRIDQLN 405
V Q +++ K++++ ++ + LA+ K + + + A + +
Sbjct: 588 VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR 647
Query: 406 RELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRD--- 462
+Q+ E++H L +K++ E++R +A AK L R + + EQ+R+ +E R+
Sbjct: 648 LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQER 707
Query: 463 ------------AMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE 510
A + R Q R QA LR+Q+++L+ E E+ +K +Q
Sbjct: 708 REQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK-KKKEEQQR 766
Query: 511 LQFRRLSQEQ 520
L R+L +EQ
Sbjct: 767 LAERQLQEEQ 776
Score = 38.5 bits (88), Expect = 0.023
Identities = 32/139 (23%), Positives = 67/139 (48%), Gaps = 13/139 (9%)
Query: 427 KLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDV 486
+++ K +F + LE+ R + +AEQ R R +E + R +L + LR V
Sbjct: 527 RMDPKCSFVEKERQRLENLRRKEEAEQLR-----RQKVEEDKRRRLEEVKLKREERLRKV 581
Query: 487 LRVQE--QELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQS 544
L+ +E +++K E ++ + +K ++ + + + +E++ A ++ + V++
Sbjct: 582 LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKM----EEVEA 637
Query: 545 HAVAEEEARKAHQLWLSVE 563
EEEAR+ WL E
Sbjct: 638 RRKQEEEARRLR--WLQQE 654
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 58.2 bits (139), Expect = 3e-08
Identities = 58/249 (23%), Positives = 108/249 (43%), Gaps = 28/249 (11%)
Query: 292 EKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELV 351
EK + +EN ++KE A E K L+ V K + + V Q E V
Sbjct: 532 EKERQRLENLRRKEEAEQLRRQKVEEDKRRR----LEEVKLK---REERLRKVLQARERV 584
Query: 352 VQARDDFKRELDSITPEVLPGWKGMSVSDLAD-----KLSTDDLNSLIAHAHRRIDQLNR 406
Q +++ K++++ ++ + LA+ K + + + A + +
Sbjct: 585 EQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL 644
Query: 407 ELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRD---- 462
+Q+ E++H L +K++ E++R +A AK L R + + EQ+R+ +E R+
Sbjct: 645 RWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR 704
Query: 463 -----------AMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL 511
A + R Q R QA LR+Q+++L+ E E+ +K +Q L
Sbjct: 705 EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK-KKKEEQQRL 763
Query: 512 QFRRLSQEQ 520
R+L +EQ
Sbjct: 764 AERQLQEEQ 772
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 57.8 bits (138), Expect = 4e-08
Identities = 92/512 (17%), Positives = 214/512 (41%), Gaps = 49/512 (9%)
Query: 110 KISSVSEVMKESKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPE-ESLKTDHPEIGEG 168
KI ++ ++++SK+ S L+K++ D A AG+ + +Q + +L+ ++ E
Sbjct: 524 KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEK 583
Query: 169 KPTPALSEEASSSSIRERPPEEVAARLAQQEK--QEQVKIESLAKSLEDALRQTASVTLQ 226
+ S + + ++ ++ E+ A A Q++ + + L L ++ + + + +Q
Sbjct: 584 LKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQ 643
Query: 227 AIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLK 286
+ A + +L +A E A K+AQ ++ L + A+ + L K
Sbjct: 644 -----------IKAKTELLLSA----EAA---KTAQRADLQNHLDTAQNALQDKQQELNK 685
Query: 287 AKEELEKMKSVIENAKKKEVAGAKPHITAAEGK---LHNMIVDLDNVVKKVQAAQSEAKV 343
+L+++ + +++ K++ + + H+ + K L +L+ +KK++A E K
Sbjct: 686 ITTQLDQVTAKLQD-KQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKA 744
Query: 344 VSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQ 403
+ +Q + +L+ E+ K + + + DL + A I Q
Sbjct: 745 SKEQALQDLQQQRQLNTDLELRATELS---KQLEMEKEIVSSTRLDLQKK-SEALESIKQ 800
Query: 404 LNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQ--------DR 455
+ E+K KQ ++ K++ + + E + +++ E
Sbjct: 801 KLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKD 860
Query: 456 KIEEVRDAMEN---EMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQ 512
K+ +V D+++N E + ++ AA D L +ELK + + + L EQ+
Sbjct: 861 KLSKVSDSLKNSKSEFEKENQKGKAAILD-----LEKTCKELKHQLQVQMENTLKEQKEL 915
Query: 513 FRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTS 572
+ L +E+ + L + + EQ +Q+ ++ ++ QL ++ LK S +
Sbjct: 916 KKSLEKEKEASHQLKLELNSMQ----EQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK 971
Query: 573 SAETPTIPLGSAVEAIKANCSDNEFTQALTAA 604
+ + + ++ +N+ Q LT A
Sbjct: 972 KKQIEALQGELKIAVLQKTELENKLQQQLTQA 1003
Score = 52.8 bits (125), Expect = 1e-06
Identities = 89/411 (21%), Positives = 167/411 (40%), Gaps = 73/411 (17%)
Query: 185 ERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNA---- 240
E+ +E+ +L Q + + + L KSLE + + L+ + Q +QA N
Sbjct: 891 EKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQN 950
Query: 241 --HSNILKAAMDNSEIAGEKKSAQWRTVEGALK----ERRKAVDEAADALLKAKEEL--E 292
L+ ++ + + E+K Q ++G LK ++ + ++ L +A +EL E
Sbjct: 951 EKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAE 1010
Query: 293 KMK-SVIENAKKKEVAGAKPHITAAEGKLHNMIV---DLDNVVKKVQAAQ----SEAKVV 344
K K SV++N +K K + G+ ++ DL +V +K+ AQ S +
Sbjct: 1011 KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQI 1070
Query: 345 SQYHELVVQAR--------DDFKRE---------LDSITPEVLPGWKGMSVSDLA-DKLS 386
++L+ + + D K+E L I E K + +L +K
Sbjct: 1071 GNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKE-----KSLKEKELVNEKSK 1125
Query: 387 TDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHR 446
++ + + I +LN EL K + IT + ++L L +
Sbjct: 1126 LAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQL-------------LIQQK 1172
Query: 447 SEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEF---EQNLS 503
E+Q + D ++ A+E E R Q L+D ++ +E+ELK EF E L
Sbjct: 1173 LELQGKAD----SLKAAVEQEKRNQ---------QILKDQVKKEEEELKKEFIEKEAKLH 1219
Query: 504 EKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARK 554
++ E+E+ ++ +E T+ I L +++ QS E K
Sbjct: 1220 SEIKEKEVGMKK-HEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEK 1269
Score = 44.3 bits (103), Expect = 4e-04
Identities = 71/346 (20%), Positives = 146/346 (42%), Gaps = 41/346 (11%)
Query: 110 KISSVSEVMKESKQPASQLQKQ--KGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGE 167
KIS + ++S++ QLQ ++ AT D SV +E L ++ +IG
Sbjct: 1013 KISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGN 1072
Query: 168 GKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQA 227
L +E ++ A L Q +++ +++ K+L+D ++ + +
Sbjct: 1073 QNK---LIQELKTAK----------ATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKEL 1119
Query: 228 IAAQN--AAVQAVNAHSNI----LKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAA 281
+ ++ A ++ + L + + ++ K+ + + L +++ + A
Sbjct: 1120 VNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA 1179
Query: 282 DALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEA 341
D+L A E+ ++ + ++++ KKE K E KLH+ I + + +KK + ++EA
Sbjct: 1180 DSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHE--ENEA 1237
Query: 342 KVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMS--VSDLADKLSTDDLNSLIA--HA 397
K+ Q L L ++ E W+ VS+L + TDDL IA A
Sbjct: 1238 KLTMQITAL--------NENLGTVKKE----WQSSQRRVSEL--EKQTDDLRGEIAVLEA 1283
Query: 398 HRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALE 443
+ +Q R ++ + + L+ + LE +R D+ A E
Sbjct: 1284 TVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQE 1329
Score = 43.9 bits (102), Expect = 5e-04
Identities = 98/499 (19%), Positives = 195/499 (39%), Gaps = 56/499 (11%)
Query: 115 SEVMKESKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGKPT--- 171
SE +K+ + LQ+Q+ T D+ + Q E +T++ I + K
Sbjct: 106 SEELKKELEKYQGLQQQEAKPDGLVT--DSSAELQSLEQQLEEAQTENFNIKQMKDLFEQ 163
Query: 172 PALSEEASSSSIRERPPEEVAARLAQQEK-----QEQVKIESLAKSLEDALRQTASVTLQ 226
A + I+ + EE + R A ++K +E K ++ + L+ L Q +
Sbjct: 164 KAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDV 223
Query: 227 AIAAQNAAVQAVNAHSNILKAAMDNSEIAGE--KKSAQWRTVEGALKERRKAVDEAADAL 284
A+ + + L+ ++ ++ E K +Q+ + E + + R + + +
Sbjct: 224 AVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEV 283
Query: 285 LKAKEELEKMKSVI-----------ENAKKKEVAGAK---PHITAAEGK------LHNMI 324
+EL+K+KS + EN KKE K H + K LH
Sbjct: 284 AVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKD 343
Query: 325 VDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADK 384
+D + ++ A+++ + +A K EL EV ++ + +
Sbjct: 344 LDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELS----EVETKYQHLKAEFKQLQ 399
Query: 385 LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEH 444
++ I+QL+ +L E TE+Q L +L+E+R S E
Sbjct: 400 QQREEKEQHGLQLQSEINQLHSKLLE---TERQ---LGEAHGRLKEQRQLSSEKLMDKEQ 453
Query: 445 HRSEIQAEQDRKIEEVRDAMEN--EMRTQLRRQAAAHTDH--LRDVLRVQEQELKSEFEQ 500
+++Q + R E++++ + N E++ QL + H + L+ + +E +++ EQ
Sbjct: 454 QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQ 513
Query: 501 NL------SEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARK 554
L +K+ E ++ S+E + + YA+++ E AV + K
Sbjct: 514 VLRQIGDKDQKIQNLEALLQK-SKENISLLEKEREDLYAKIQAGEGET---AVLNQLQEK 569
Query: 555 AHQLWLSVEALKYSMKTSS 573
H L V L +K S
Sbjct: 570 NHTLQEQVTQLTEKLKNQS 588
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 57.4 bits (137), Expect = 5e-08
Identities = 92/410 (22%), Positives = 178/410 (43%), Gaps = 62/410 (15%)
Query: 175 SEEASSSSI-RERPPEEVAARLAQQEKQE--QVKIESLAKSLEDALRQTASVTLQAIAAQ 231
+E + +SSI RE E+ Q+ E QVK E+L K L+ + A + +A++ Q
Sbjct: 767 AESSKASSITRELQGRELKLTNLQENLSEVSQVK-ETLEKELQILKEKFAEASEEAVSVQ 825
Query: 232 NAAVQAVNA-HSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEE 290
+ + VN H + M +S++ EK +E +E+ DE + L+KAKE+
Sbjct: 826 RSMQETVNKLHQKEEQFNMLSSDL--EKLRENLADMEAKFREK----DEREEQLIKAKEK 879
Query: 291 LEK-----MKSVIENA------------KKKEVAGAKPHITAAEGKLHNMIVDLDNVVKK 333
LE MK +N+ K+++V + +T A + ++++ K
Sbjct: 880 LENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVK 939
Query: 334 VQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLST--DDLN 391
+ +Q EA + ++ K+EL+ +SDL K+ T +
Sbjct: 940 AEQSQQEA----------AKKHEEEKKELE------------RKLSDLEKKMETSHNQCQ 977
Query: 392 SLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQA 451
L A R + + ++ + TL + KL+ R +S + + LE R QA
Sbjct: 978 ELKARYERATSETKTK--HEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK--QA 1033
Query: 452 EQDRKIEEVRDAME-NEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLS--EKLSE 508
++ + + DAM+ E T+ + + A + + + EL + E NL E+L++
Sbjct: 1034 DKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNK 1093
Query: 509 QELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 558
+ + + ++++ F +I T + +++ Q A+ EE + A +L
Sbjct: 1094 SK-ELLTVENQKMEEFRKEIET--LKQAAAQKSQQLSALQEENVKLAEEL 1140
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 57.4 bits (137), Expect = 5e-08
Identities = 92/410 (22%), Positives = 178/410 (43%), Gaps = 62/410 (15%)
Query: 175 SEEASSSSI-RERPPEEVAARLAQQEKQE--QVKIESLAKSLEDALRQTASVTLQAIAAQ 231
+E + +SSI RE E+ Q+ E QVK E+L K L+ + A + +A++ Q
Sbjct: 802 AESSKASSITRELQGRELKLTNLQENLSEVSQVK-ETLEKELQILKEKFAEASEEAVSVQ 860
Query: 232 NAAVQAVNA-HSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEE 290
+ + VN H + M +S++ EK +E +E+ DE + L+KAKE+
Sbjct: 861 RSMQETVNKLHQKEEQFNMLSSDL--EKLRENLADMEAKFREK----DEREEQLIKAKEK 914
Query: 291 LEK-----MKSVIENA------------KKKEVAGAKPHITAAEGKLHNMIVDLDNVVKK 333
LE MK +N+ K+++V + +T A + ++++ K
Sbjct: 915 LENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVK 974
Query: 334 VQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLST--DDLN 391
+ +Q EA + ++ K+EL+ +SDL K+ T +
Sbjct: 975 AEQSQQEA----------AKKHEEEKKELE------------RKLSDLEKKMETSHNQCQ 1012
Query: 392 SLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQA 451
L A R + + ++ + TL + KL+ R +S + + LE R QA
Sbjct: 1013 ELKARYERATSETKTK--HEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK--QA 1068
Query: 452 EQDRKIEEVRDAME-NEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLS--EKLSE 508
++ + + DAM+ E T+ + + A + + + EL + E NL E+L++
Sbjct: 1069 DKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNK 1128
Query: 509 QELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 558
+ + + ++++ F +I T + +++ Q A+ EE + A +L
Sbjct: 1129 SK-ELLTVENQKMEEFRKEIET--LKQAAAQKSQQLSALQEENVKLAEEL 1175
Score = 36.2 bits (82), Expect = 0.11
Identities = 31/124 (25%), Positives = 65/124 (52%), Gaps = 8/124 (6%)
Query: 394 IAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQ 453
+A A + ++ +ELA + QH+ L LE K+++ R A + ++++ E+
Sbjct: 378 VAKATSHVGEIEQELALARDGHDQHV-LELEA-KMDQLRTMVEAADREKVELLNQLE-EE 434
Query: 454 DRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQF 513
RK+E+++ +E E T+ + +H R++E E FE+ ++KL ++EL+
Sbjct: 435 KRKVEDLQFRVEEESITKGDLETQTKLEH----ARIKELEQSLLFEKTKADKL-QRELED 489
Query: 514 RRLS 517
R++
Sbjct: 490 TRVA 493
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 57.0 bits (136), Expect = 6e-08
Identities = 105/516 (20%), Positives = 213/516 (41%), Gaps = 82/516 (15%)
Query: 110 KISSVSEVMKESKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPE-ESLKTDHPEIGEG 168
K S VS++ + + Q ++ K A + L+ + + + + L+ + E EG
Sbjct: 1295 KESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEG 1354
Query: 169 KPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV----- 223
K + ++S + + + + + E+ E+ K + LA+ L+D+ Q +V
Sbjct: 1355 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK-KKLAQRLQDSEEQVEAVNAKCA 1413
Query: 224 ----TLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRT--------VEGALK 271
T Q + + + +N L AA+D + +K A+W+T +E +LK
Sbjct: 1414 SLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLK 1473
Query: 272 ERR----------KAVDEAADALLKAKEELEKM--------KSVIENAK--------KKE 305
E R A +EA D L K E + + + + EN K +K+
Sbjct: 1474 ESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQ 1533
Query: 306 VAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAK-----VVSQYHELVVQARDDFKR 360
+ K I A + + + + ++Q ++ K +++ E + Q + +++R
Sbjct: 1534 IELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQR 1593
Query: 361 ELDSITPEVLPGWKGMSVSDLADKLSTDDLNSL---IAHAHRRIDQLNRELAEQKATEKQ 417
++++ + + + + K DLN + ++HA+R+ + + L + K
Sbjct: 1594 TVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKD 1653
Query: 418 ---HITLALEKQK-LEEKRAFDSAVAKALEHHRSEI-----QAEQDRKIEEVRDAMENEM 468
H+ AL Q+ L+E+ A A L+ E+ Q E+ RK+ E ++ +++
Sbjct: 1654 TQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAE-QELLDSNE 1712
Query: 469 RTQLRRQAAAHTDHLRDVLRVQEQELKSEFE------QNLSEK----LSEQELQFRRLSQ 518
R QL H + L +L+SE E +N EK +++ + L +
Sbjct: 1713 RVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKK 1772
Query: 519 EQVDNFTLDINTAYARL-RGIEQAVQ--SHAVAEEE 551
EQ D + R+ + +EQ V+ H + E E
Sbjct: 1773 EQ------DTSAHLERMKKNLEQTVKDLQHRLDEAE 1802
Score = 47.4 bits (111), Expect = 5e-05
Identities = 98/473 (20%), Positives = 190/473 (40%), Gaps = 69/473 (14%)
Query: 177 EASSSSIRERPP--EEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAA 234
EA + ER EE+ A L ++++ + + L K ++D A V + A +N
Sbjct: 917 EAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 976
Query: 235 VQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKM 294
S + + +++ EKK+ Q + AL + + A ++ ++L K K +LE+
Sbjct: 977 KNLTEELSGLDETI---AKLTREKKALQ-EAHQQALDDLQ-AEEDKVNSLNKTKSKLEQQ 1031
Query: 295 KSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQA 354
+E++ ++E + VDL+ +K++ A+ E ++
Sbjct: 1032 VEDLESSLEQE---------------KKLRVDLERNKRKLEGDLKLAQ------ESILDL 1070
Query: 355 RDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSL-----IAHAHRRIDQLNREL- 408
+D K++LD + K L K+ + L I RI++L E+
Sbjct: 1071 END-KQQLDERLKK-----KDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIE 1124
Query: 409 ---AEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAE---QDRKIEEV-- 460
A + TEKQ A E ++L E+ V + +AE R +EE
Sbjct: 1125 AERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATL 1184
Query: 461 -RDAMENEMRTQLRRQAAAHTDHLRDVLRVQE--QELKSEFEQNLSEKLSEQELQFRRLS 517
+AM +R + A + + ++ RV++ ++ KSEF+ + + S E + S
Sbjct: 1185 QHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSK--S 1242
Query: 518 QEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETP 577
+ ++ + + RG + +Q +++E +K+ L EA + S + E+
Sbjct: 1243 KANLEKICRTLEDQLSEARGKNEEIQ-RSLSELTTQKSR---LQTEAGELSRQLEEKESI 1298
Query: 578 TIPLGSAVEAI------------KANCSDNEFTQALTAAIPPESLTRGVYSEE 618
L + +A + N + N AL ++ L R Y EE
Sbjct: 1299 VSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEE 1351
Score = 46.2 bits (108), Expect = 1e-04
Identities = 91/419 (21%), Positives = 175/419 (41%), Gaps = 58/419 (13%)
Query: 189 EEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQ------AIAAQNAAVQAVNAHS 242
E+ A L +Q + I L KS + + A + L A+ + A + +
Sbjct: 1507 EQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLEL 1566
Query: 243 NILKAAMD------NSEIAGEKKSAQWRTVE---GALKERRKAVDEAADALLKAKEELEK 293
+K+ +D + EI K++ Q RTVE AL ++ +EA K + +L +
Sbjct: 1567 TQVKSEIDRKIAEKDEEIEQLKRNYQ-RTVETMQSALDAEVRSRNEAIRLKKKMEGDLNE 1625
Query: 294 MKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDN--------------VVKKVQAAQS 339
++ + +A ++ K H+ + +G+L + + LD+ V ++ Q+
Sbjct: 1626 IEIQLSHANRQAAETLK-HLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQA 1684
Query: 340 EAKVVSQYHELVVQARDDFKREL-DSITPEVLPGWKGMSVSDLADKLSTD--DLNSLIAH 396
E + + E +AR ++EL DS L + S+ KL TD L S +
Sbjct: 1685 EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVED 1744
Query: 397 AHRRIDQLNRELAEQKAT-----------EKQHITLALEKQK--LEE-----KRAFDSAV 438
A R D N E +KA ++Q + LE+ K LE+ + D A
Sbjct: 1745 ASR--DARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1802
Query: 439 AKALEHHRSEIQAEQDRKIEEVRDAMENEMR--TQLRRQAAAHTDHLRDVLRVQEQELKS 496
AL+ + +IQ + R I E+ +E E + T+ + + ++++ E++ K+
Sbjct: 1803 QLALKGGKKQIQKLETR-IRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKN 1861
Query: 497 EFE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARK 554
Q+L +KL + ++R ++E + + +E+A + +AE + K
Sbjct: 1862 VLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNK 1920
Score = 33.9 bits (76), Expect = 0.57
Identities = 75/368 (20%), Positives = 155/368 (42%), Gaps = 33/368 (8%)
Query: 207 ESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK---KSAQW 263
E+L K + + LR T ++ I HS +L N + G + K
Sbjct: 654 ENLNKLMSN-LRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPN 712
Query: 264 RTVEGALKERRKAVDEAA---DALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAE--G 318
R + G K+R + ++ +A + +K+ EK+ + I+ + G A G
Sbjct: 713 RILYGDFKQRYRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLG 772
Query: 319 KLHNMIVD-LDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMS 377
L M D L ++ + QA + ++ ++V + F + + + + W M
Sbjct: 773 TLEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCIQYNIRSFMNVKHWPWMK 832
Query: 378 ----VSDLADKLSTD-DLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLE-EK 431
+ L T+ ++ ++ + D+L + A++K E++ +TL EK L+ +
Sbjct: 833 LFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQV 892
Query: 432 RAFDSAVAKALEHHRSEIQA--EQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRV 489
+A + A E I+A + + KI+EV + E+E ++ + A L D
Sbjct: 893 QAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDE--EEINAELTAKKRKLED---- 946
Query: 490 QEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAE 549
+ ELK + + +L L++ E + + ++ +V N T L G+++ + +
Sbjct: 947 ECSELKKDID-DLELTLAKVEKE-KHATENKVKNLT-------EELSGLDETIAKLTREK 997
Query: 550 EEARKAHQ 557
+ ++AHQ
Sbjct: 998 KALQEAHQ 1005
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 56.6 bits (135), Expect = 8e-08
Identities = 79/424 (18%), Positives = 185/424 (43%), Gaps = 56/424 (13%)
Query: 110 KISSVSEVMKESKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGK 169
KI ++ E +++ ++ S L+++ A T DT
Sbjct: 579 KIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDT------------------------- 613
Query: 170 PTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA 229
AL+ + + +ER E + + + E+++Q +I++ K L+D L++ S+ ++
Sbjct: 614 ---ALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKD-LKEKVSLLQGDLS 669
Query: 230 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 289
+ A++ + H++ L + +G KK ++ +T+E AL+++++ + L KA E
Sbjct: 670 EKEASLLDLKEHASSLAS-------SGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHE 722
Query: 290 ELEKMKSVIENAKK-----KEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVV 344
+ ++ E + + +E+ K + A+ ++ ++ ++K+V+ +++
Sbjct: 723 AALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLL----EILKEVENEKNDKD-- 776
Query: 345 SQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLA----DKL--STDDLNSLIAHAH 398
+ EL Q +D K+ + E + K + + A D L S+ L +
Sbjct: 777 KKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKD 836
Query: 399 RRIDQLNRELAEQ-KATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKI 457
RI++L L E + T ++ + LA E+ + A+E + E+++ K+
Sbjct: 837 DRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELES-MKAKL 895
Query: 458 EEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLS 517
+ ++ E T L A HL +VL ++++ L + + + + ++ +
Sbjct: 896 SSTQQSLA-EKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKT 954
Query: 518 QEQV 521
QE+V
Sbjct: 955 QEEV 958
Score = 53.9 bits (128), Expect = 5e-07
Identities = 68/321 (21%), Positives = 149/321 (46%), Gaps = 42/321 (13%)
Query: 174 LSEEASS---SSIRERPPEEVAARLAQQEKQEQVKIES-LAKSLEDALRQTASVTLQ-AI 228
L E ASS S +++ + +Q+K+E +K+ES L K+ E AL AS + I
Sbjct: 678 LKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRI 737
Query: 229 AAQNAAVQAVNAHSNILKAAMDN-----SEIAGEK--KSAQWRTVEGALKERRKAVDEAA 281
+ S+ +A +D E+ EK K + +E +K++ K V
Sbjct: 738 QHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKV---- 793
Query: 282 DALLKAKEELEKMKS--VIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQS 339
A LK KE++EK KS ++E A+++E ++ + +L + + D+ +++++ A
Sbjct: 794 -ANLKHKEQVEKKKSAQMLEEARRRE-----DNLNDSSQQLQDSLRKKDDRIEELEEALR 847
Query: 340 EAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHR 399
E+ ++ E+V+ + + + E+L M++ + +L + + + ++ +
Sbjct: 848 ESVQITAEREMVLAQEESARTNAEKQVEELL-----MAMEKVKQEL--ESMKAKLSSTQQ 900
Query: 400 RIDQLNRELAEQKATEKQHITLALEKQK------LEEKRAFD-----SAVAKALEHHRSE 448
+ + L +A ++H+ LE ++ + EK A S+ K + +
Sbjct: 901 SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAA 960
Query: 449 IQAEQDRKIEEVRDAMENEMR 469
++ E+DR +++++ +N M+
Sbjct: 961 LKREKDRLVQQLKQQTQNRMK 981
Score = 43.1 bits (100), Expect = 0.001
Identities = 77/421 (18%), Positives = 180/421 (42%), Gaps = 55/421 (13%)
Query: 195 LAQQEKQEQVKIESLAKSLEDALRQTASVTLQA--------IAAQNAAVQAVNAHSNILK 246
L Q+EK+ + E + + E+A + LQ I++ ++ + +LK
Sbjct: 350 LEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLK 409
Query: 247 AAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEV 306
+ N ++ E++ + + +E + K + + L KEEL ++ E KKK
Sbjct: 410 S---NGALSTEEREEEMKQME-VYRSHSKFMKNKVEQL---KEELSSKEAQWEELKKK-A 461
Query: 307 AGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSIT 366
AG + I + +L +L + K++ ++ Q+ E++ ++ ++ +
Sbjct: 462 AGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQ 521
Query: 367 PEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQ 426
EV A +L ++ +++ ++I +++AE+K T+ I +
Sbjct: 522 TEVD-----------ALRLRLEEKETMLNKKTKQI----QDMAEEKGTQAGEIHDLKDML 566
Query: 427 KLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDV 486
++E++ + + K +E+ + +++ ++++++ +++ +++ A T L +
Sbjct: 567 DVKERKV--NVLQKKIENLQEQLR-DKEKQMSSLKERVKSLQADTTNTDTALTT--LEEA 621
Query: 487 LRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHA 546
L +E+ + E+L EQ + R QE++DN+ D+ ++ + Q S
Sbjct: 622 LAEKERTI---------ERLKEQRDRDEREKQEEIDNYKKDLKDLKEKV-SLLQGDLSEK 671
Query: 547 VAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANC--SDNEFTQALTAA 604
A K H L+ LK + + E A+E K C +++ +A AA
Sbjct: 672 EASLLDLKEHASSLASSGLKKDSRLKTLEI-------ALEQKKEECLKMESQLKKAHEAA 724
Query: 605 I 605
+
Sbjct: 725 L 725
Score = 33.1 bits (74), Expect = 0.97
Identities = 82/388 (21%), Positives = 151/388 (38%), Gaps = 65/388 (16%)
Query: 217 LRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKA 276
+R TA + IA+ A + + L S + + A+ T+ L+ + K
Sbjct: 102 VRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMD-LQTQLKE 160
Query: 277 VDEAADALLKAKEELE-KMKSVIENAK-------KKEVAGAKPH---ITAAEGKLHNMIV 325
V D L K E E K+ S + + K KKE A K IT + + +
Sbjct: 161 VLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQE 220
Query: 326 DLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL 385
+ ++ +QA Q E ++ ++L F+++ S T E +L
Sbjct: 221 ENQHMQMTIQALQDELRIQRDLNQL-------FQQDSSSRTGE-----------PCVAEL 262
Query: 386 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHH 445
+ ++ L A R+ +L +K E+ + + +KQ L + D ++ K LE
Sbjct: 263 TEENFQRLHAEHERQAKEL---FLLRKTLEEMELRIETQKQTLNAR---DESIKKLLEML 316
Query: 446 RSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE---LKSEFEQNL 502
+S K + E+ RT+ +A H HL +L +E+E L+ E +
Sbjct: 317 QS--------KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRF 368
Query: 503 SEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQ--------SHAVAEEEAR- 553
+ + + E D+ I++ LR +E+ +Q S EEE +
Sbjct: 369 ENAPDSAKTKALQTVIEMKDS---KISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQ 425
Query: 554 ----KAHQLWL--SVEALKYSMKTSSAE 575
++H ++ VE LK + + A+
Sbjct: 426 MEVYRSHSKFMKNKVEQLKEELSSKEAQ 453
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 56.6 bits (135), Expect = 8e-08
Identities = 79/424 (18%), Positives = 185/424 (43%), Gaps = 56/424 (13%)
Query: 110 KISSVSEVMKESKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGK 169
KI ++ E +++ ++ S L+++ A T DT
Sbjct: 551 KIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDT------------------------- 585
Query: 170 PTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA 229
AL+ + + +ER E + + + E+++Q +I++ K L+D L++ S+ ++
Sbjct: 586 ---ALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKD-LKEKVSLLQGDLS 641
Query: 230 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 289
+ A++ + H++ L + +G KK ++ +T+E AL+++++ + L KA E
Sbjct: 642 EKEASLLDLKEHASSLAS-------SGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHE 694
Query: 290 ELEKMKSVIENAKK-----KEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVV 344
+ ++ E + + +E+ K + A+ ++ ++ ++K+V+ +++
Sbjct: 695 AALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLL----EILKEVENEKNDKD-- 748
Query: 345 SQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLA----DKL--STDDLNSLIAHAH 398
+ EL Q +D K+ + E + K + + A D L S+ L +
Sbjct: 749 KKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKD 808
Query: 399 RRIDQLNRELAEQ-KATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKI 457
RI++L L E + T ++ + LA E+ + A+E + E+++ K+
Sbjct: 809 DRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELES-MKAKL 867
Query: 458 EEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLS 517
+ ++ E T L A HL +VL ++++ L + + + + ++ +
Sbjct: 868 SSTQQSLA-EKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKT 926
Query: 518 QEQV 521
QE+V
Sbjct: 927 QEEV 930
Score = 53.9 bits (128), Expect = 5e-07
Identities = 68/321 (21%), Positives = 149/321 (46%), Gaps = 42/321 (13%)
Query: 174 LSEEASS---SSIRERPPEEVAARLAQQEKQEQVKIES-LAKSLEDALRQTASVTLQ-AI 228
L E ASS S +++ + +Q+K+E +K+ES L K+ E AL AS + I
Sbjct: 650 LKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRI 709
Query: 229 AAQNAAVQAVNAHSNILKAAMDN-----SEIAGEK--KSAQWRTVEGALKERRKAVDEAA 281
+ S+ +A +D E+ EK K + +E +K++ K V
Sbjct: 710 QHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKV---- 765
Query: 282 DALLKAKEELEKMKS--VIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQS 339
A LK KE++EK KS ++E A+++E ++ + +L + + D+ +++++ A
Sbjct: 766 -ANLKHKEQVEKKKSAQMLEEARRRE-----DNLNDSSQQLQDSLRKKDDRIEELEEALR 819
Query: 340 EAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHR 399
E+ ++ E+V+ + + + E+L M++ + +L + + + ++ +
Sbjct: 820 ESVQITAEREMVLAQEESARTNAEKQVEELL-----MAMEKVKQEL--ESMKAKLSSTQQ 872
Query: 400 RIDQLNRELAEQKATEKQHITLALEKQK------LEEKRAFD-----SAVAKALEHHRSE 448
+ + L +A ++H+ LE ++ + EK A S+ K + +
Sbjct: 873 SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAA 932
Query: 449 IQAEQDRKIEEVRDAMENEMR 469
++ E+DR +++++ +N M+
Sbjct: 933 LKREKDRLVQQLKQQTQNRMK 953
Score = 43.9 bits (102), Expect = 5e-04
Identities = 108/475 (22%), Positives = 197/475 (41%), Gaps = 65/475 (13%)
Query: 174 LSEEASSSSIRERPPEEVAARLAQQEKQE-QVKIESLAKSLEDALRQTASVTLQAIAAQN 232
L ++ SSS R E A L ++ Q + E AK L LR+T I Q
Sbjct: 245 LFQQDSSS----RTGEPCVAELTEENFQRLHAEHERQAKELF-LLRKTLEEMELRIETQK 299
Query: 233 AAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEA----ADALLKAK 288
Q +NA +K ++ + G A T E + RR A E ++LL+ K
Sbjct: 300 ---QTLNARDESIKKLLEMLQSKGLSAKA---TEEDHERTRRLAEAEMHVHHLESLLEQK 353
Query: 289 EE-----LEKMKSVIENAKKKEVAGA-KPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAK 342
E+ E+M ENA A + I + K+ +M L ++ +++Q +S
Sbjct: 354 EKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGA 413
Query: 343 VVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSD---LADKLSTDDLNSLIAHAHR 399
+ ++ E ++ + ++ + ++ + +S D LA + + L + + + +
Sbjct: 414 LSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQ 473
Query: 400 RIDQLNRELA--EQKA----TEKQHITLALEKQKL----EEKRAFDSAVAKALE----HH 445
I+ L L EQ+A TE + L LE+++ + K+ D A K + H
Sbjct: 474 HIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHD 533
Query: 446 RSEIQAEQDRKIEEVRDAMENEMRTQLR-------------RQAAAHTDHLRDVLRVQEQ 492
++ ++RK+ ++ +EN ++ QLR + A T + L E+
Sbjct: 534 LKDMLDVKERKVNVLQKKIEN-LQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE 592
Query: 493 ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEA 552
L +E E+ + E+L EQ + R QE++DN+ D+ ++ + Q S A
Sbjct: 593 AL-AEKERTI-ERLKEQRDRDEREKQEEIDNYKKDLKDLKEKV-SLLQGDLSEKEASLLD 649
Query: 553 RKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANC--SDNEFTQALTAAI 605
K H L+ LK + + E A+E K C +++ +A AA+
Sbjct: 650 LKEHASSLASSGLKKDSRLKTLEI-------ALEQKKEECLKMESQLKKAHEAAL 697
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.126 0.341
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,638,997
Number of Sequences: 37866
Number of extensions: 1156303
Number of successful extensions: 8179
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 830
Number of HSP's that attempted gapping in prelim test: 5980
Number of HSP's gapped (non-prelim): 2326
length of query: 747
length of database: 18,247,518
effective HSP length: 110
effective length of query: 637
effective length of database: 14,082,258
effective search space: 8970398346
effective search space used: 8970398346
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.