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Search of human proteins with 154354964
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154354964 inner membrane protein, mitochondrial isoform 1
[Homo sapiens]
(758 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154354964 inner membrane protein, mitochondrial isoform 1 [Ho... 1458 0.0
gi|154354962 inner membrane protein, mitochondrial isoform 2 [Ho... 1451 0.0
gi|154354966 inner membrane protein, mitochondrial isoform 3 [Ho... 1430 0.0
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 72 2e-12
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 72 2e-12
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 72 2e-12
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 70 6e-12
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 65 2e-10
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 64 7e-10
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 64 7e-10
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 64 7e-10
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 64 7e-10
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 64 7e-10
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 64 7e-10
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 64 7e-10
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 64 7e-10
gi|110611218 ribosome binding protein 1 [Homo sapiens] 62 3e-09
gi|110611220 ribosome binding protein 1 [Homo sapiens] 62 3e-09
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 59 1e-08
gi|42794779 myosin 18A isoform b [Homo sapiens] 59 2e-08
gi|28416946 myosin 18A isoform a [Homo sapiens] 59 2e-08
gi|55770834 centromere protein F [Homo sapiens] 59 2e-08
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 59 2e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 58 3e-08
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 58 3e-08
gi|38044112 restin isoform b [Homo sapiens] 57 5e-08
gi|4506751 restin isoform a [Homo sapiens] 57 5e-08
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 57 6e-08
gi|9910266 kinesin family member 15 [Homo sapiens] 56 1e-07
gi|21735548 centrosomal protein 2 [Homo sapiens] 56 1e-07
>gi|154354964 inner membrane protein, mitochondrial isoform 1 [Homo
sapiens]
Length = 758
Score = 1458 bits (3774), Expect = 0.0
Identities = 758/758 (100%), Positives = 758/758 (100%)
Query: 1 MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG 60
MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG
Sbjct: 1 MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG 60
Query: 61 TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE 120
TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE
Sbjct: 61 TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE 120
Query: 121 SKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGK 180
SKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGK
Sbjct: 121 SKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGK 180
Query: 181 PTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA 240
PTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA
Sbjct: 181 PTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA 240
Query: 241 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 300
AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE
Sbjct: 241 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 300
Query: 301 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE 360
ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE
Sbjct: 301 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE 360
Query: 361 LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA 420
LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA
Sbjct: 361 LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA 420
Query: 421 EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR 480
EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR
Sbjct: 421 EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR 480
Query: 481 TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN 540
TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN
Sbjct: 481 TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN 540
Query: 541 TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK 600
TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK
Sbjct: 541 TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK 600
Query: 601 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL 660
ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL
Sbjct: 601 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL 660
Query: 661 SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV 720
SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV
Sbjct: 661 SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV 720
Query: 721 AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE 758
AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE
Sbjct: 721 AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE 758
>gi|154354962 inner membrane protein, mitochondrial isoform 2 [Homo
sapiens]
Length = 757
Score = 1451 bits (3757), Expect = 0.0
Identities = 757/758 (99%), Positives = 757/758 (99%), Gaps = 1/758 (0%)
Query: 1 MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG 60
MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG
Sbjct: 1 MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG 60
Query: 61 TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE 120
TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE
Sbjct: 61 TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE 120
Query: 121 SKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGK 180
SKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGK
Sbjct: 121 SKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGK 180
Query: 181 PTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA 240
PTPALSE ASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA
Sbjct: 181 PTPALSE-ASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA 239
Query: 241 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 300
AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE
Sbjct: 240 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 299
Query: 301 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE 360
ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE
Sbjct: 300 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE 359
Query: 361 LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA 420
LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA
Sbjct: 360 LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA 419
Query: 421 EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR 480
EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR
Sbjct: 420 EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR 479
Query: 481 TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN 540
TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN
Sbjct: 480 TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN 539
Query: 541 TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK 600
TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK
Sbjct: 540 TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK 599
Query: 601 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL 660
ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL
Sbjct: 600 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL 659
Query: 661 SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV 720
SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV
Sbjct: 660 SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV 719
Query: 721 AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE 758
AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE
Sbjct: 720 AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE 757
>gi|154354966 inner membrane protein, mitochondrial isoform 3 [Homo
sapiens]
Length = 747
Score = 1430 bits (3702), Expect = 0.0
Identities = 747/758 (98%), Positives = 747/758 (98%), Gaps = 11/758 (1%)
Query: 1 MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG 60
MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG
Sbjct: 1 MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG 60
Query: 61 TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE 120
TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE
Sbjct: 61 TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE 120
Query: 121 SKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGK 180
SKQPASQLQKQKGDTPASATA GDTLSVPAPAVQPEESLKTDHPEIGEGK
Sbjct: 121 SKQPASQLQKQKGDTPASATA-----------GDTLSVPAPAVQPEESLKTDHPEIGEGK 169
Query: 181 PTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA 240
PTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA
Sbjct: 170 PTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA 229
Query: 241 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 300
AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE
Sbjct: 230 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 289
Query: 301 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE 360
ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE
Sbjct: 290 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE 349
Query: 361 LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA 420
LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA
Sbjct: 350 LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA 409
Query: 421 EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR 480
EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR
Sbjct: 410 EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR 469
Query: 481 TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN 540
TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN
Sbjct: 470 TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN 529
Query: 541 TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK 600
TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK
Sbjct: 530 TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK 589
Query: 601 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL 660
ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL
Sbjct: 590 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL 649
Query: 661 SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV 720
SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV
Sbjct: 650 SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV 709
Query: 721 AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE 758
AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE
Sbjct: 710 AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE 747
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 72.0 bits (175), Expect = 2e-12
Identities = 123/531 (23%), Positives = 215/531 (40%), Gaps = 87/531 (16%)
Query: 112 SSVSEVMKESKQPASQLQKQKGDTP-----ASATAPTEA---AQIISAAGDTLSVPAPAV 163
S + E M E +Q A +L+ Q G A A A E AQ++ + + + A A
Sbjct: 1090 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1149
Query: 164 QPEESLKT-------DHPEIGE------GKPTPALSEEASSSSIRERPPEEVAARLAQQE 210
+ ES + ++GE G+ L + +R + +EV E
Sbjct: 1150 EDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLE 1209
Query: 211 KQEQVK--------------IESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNIL 256
++ ++ + LA+ LE A R + +A + A V + A + L
Sbjct: 1210 EETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE-AEVSELRAELSSL 1268
Query: 257 KAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKE 316
+ A E + Q + V+G + +A EAA+ L +A+ ELE + + A+ K
Sbjct: 1269 QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1328
Query: 317 VAGAKPHITAAEGKLHNMIVDLDNVVK-------KVQAAQSEAKVVSQYHELVVQARDDF 369
+ +K +++ E +LH+ L + +V+A ++EA + + E AR+
Sbjct: 1329 IRLSK-ELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERA 1387
Query: 370 KRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKAT---- 425
REL + + L W+ + + ++ A R + L + LAE+ T
Sbjct: 1388 GRELQTAQAQ-LSEWRRRQEEEAGALEAGEEAR---RRAAREAEALTQRLAEKTETVDRL 1443
Query: 426 ---------EKQHITLALEKQK-----LEEK-RAFDSAVAKALEHHRSEIQAEQDRKIEE 470
E T+ LE+Q+ LE+K R FD +A E + ++A ++R+ E
Sbjct: 1444 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLA---EEKAAVLRAVEERERAE 1500
Query: 471 VRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEK----LSEQELQFRR 526
+ E E R +A R+ L Q + L++E E LS K S EL+
Sbjct: 1501 A-EGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERAC 1559
Query: 527 LSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALK 577
EQ N LR ++ A E+A+ +L ++V+ALK
Sbjct: 1560 RVAEQAAN----------DLRAQVTELEDELTAAEDAKL--RLEVTVQALK 1598
Score = 40.0 bits (92), Expect = 0.008
Identities = 79/392 (20%), Positives = 155/392 (39%), Gaps = 57/392 (14%)
Query: 200 EEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAA 259
EE RLA ++++ ++ + L + + + + + Q +Q + AH + A
Sbjct: 932 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH-IQELEAHLEAEEGA 990
Query: 260 MDNSEIAGEKKSAQWRTVEGAL-----------KERRKAVDEAADALLKAKEELEKMKSV 308
++ A+ + E L KER+ D A+ +A EE EK+KS+
Sbjct: 991 RQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSL 1050
Query: 309 IENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDD 368
+ K E I D+++ ++K + + E +
Sbjct: 1051 NKLRLKYEAT----------------IADMEDRLRKEEKGRQEL--------------EK 1080
Query: 369 FKRELDSITPEVLPGW--KGMSVSDLADKL--STDDLNSLIAHAHRRIDQLNRELAEQKA 424
KR LD + E+ + +L +L ++L + +A A D+ K+
Sbjct: 1081 LKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE---DEGGARAQLLKS 1137
Query: 425 TEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDA--MENEMRTQ 482
+ LA ++ LE +R + K E++A + ++E+ D+ + E+R++
Sbjct: 1138 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRG-ELEDTLDSTNAQQELRSK 1196
Query: 483 LRRQAAAHTDHLRDVLRVQE---QELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDI 539
++ L + R+ E QEL+ Q L E L+EQ Q RR + + L +
Sbjct: 1197 REQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE-LAEQLEQARR-GKGAWEKTRLAL 1254
Query: 540 NTAYARLRGIEQAVQSHAVAEEEARKAHQLWL 571
+ LR ++Q+ E+ R+ +L L
Sbjct: 1255 EAEVSELRAELSSLQTARQEGEQRRRRLELQL 1286
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 72.0 bits (175), Expect = 2e-12
Identities = 123/531 (23%), Positives = 215/531 (40%), Gaps = 87/531 (16%)
Query: 112 SSVSEVMKESKQPASQLQKQKGDTP-----ASATAPTEA---AQIISAAGDTLSVPAPAV 163
S + E M E +Q A +L+ Q G A A A E AQ++ + + + A A
Sbjct: 1082 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1141
Query: 164 QPEESLKT-------DHPEIGE------GKPTPALSEEASSSSIRERPPEEVAARLAQQE 210
+ ES + ++GE G+ L + +R + +EV E
Sbjct: 1142 EDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLE 1201
Query: 211 KQEQVK--------------IESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNIL 256
++ ++ + LA+ LE A R + +A + A V + A + L
Sbjct: 1202 EETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE-AEVSELRAELSSL 1260
Query: 257 KAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKE 316
+ A E + Q + V+G + +A EAA+ L +A+ ELE + + A+ K
Sbjct: 1261 QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1320
Query: 317 VAGAKPHITAAEGKLHNMIVDLDNVVK-------KVQAAQSEAKVVSQYHELVVQARDDF 369
+ +K +++ E +LH+ L + +V+A ++EA + + E AR+
Sbjct: 1321 IRLSK-ELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERA 1379
Query: 370 KRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKAT---- 425
REL + + L W+ + + ++ A R + L + LAE+ T
Sbjct: 1380 GRELQTAQAQ-LSEWRRRQEEEAGALEAGEEAR---RRAAREAEALTQRLAEKTETVDRL 1435
Query: 426 ---------EKQHITLALEKQK-----LEEK-RAFDSAVAKALEHHRSEIQAEQDRKIEE 470
E T+ LE+Q+ LE+K R FD +A E + ++A ++R+ E
Sbjct: 1436 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLA---EEKAAVLRAVEERERAE 1492
Query: 471 VRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEK----LSEQELQFRR 526
+ E E R +A R+ L Q + L++E E LS K S EL+
Sbjct: 1493 A-EGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERAC 1551
Query: 527 LSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALK 577
EQ N LR ++ A E+A+ +L ++V+ALK
Sbjct: 1552 RVAEQAAN----------DLRAQVTELEDELTAAEDAKL--RLEVTVQALK 1590
Score = 40.0 bits (92), Expect = 0.008
Identities = 79/392 (20%), Positives = 155/392 (39%), Gaps = 57/392 (14%)
Query: 200 EEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAA 259
EE RLA ++++ ++ + L + + + + + Q +Q + AH + A
Sbjct: 924 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH-IQELEAHLEAEEGA 982
Query: 260 MDNSEIAGEKKSAQWRTVEGAL-----------KERRKAVDEAADALLKAKEELEKMKSV 308
++ A+ + E L KER+ D A+ +A EE EK+KS+
Sbjct: 983 RQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSL 1042
Query: 309 IENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDD 368
+ K E I D+++ ++K + + E +
Sbjct: 1043 NKLRLKYEAT----------------IADMEDRLRKEEKGRQEL--------------EK 1072
Query: 369 FKRELDSITPEVLPGW--KGMSVSDLADKL--STDDLNSLIAHAHRRIDQLNRELAEQKA 424
KR LD + E+ + +L +L ++L + +A A D+ K+
Sbjct: 1073 LKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE---DEGGARAQLLKS 1129
Query: 425 TEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDA--MENEMRTQ 482
+ LA ++ LE +R + K E++A + ++E+ D+ + E+R++
Sbjct: 1130 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRG-ELEDTLDSTNAQQELRSK 1188
Query: 483 LRRQAAAHTDHLRDVLRVQE---QELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDI 539
++ L + R+ E QEL+ Q L E L+EQ Q RR + + L +
Sbjct: 1189 REQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE-LAEQLEQARR-GKGAWEKTRLAL 1246
Query: 540 NTAYARLRGIEQAVQSHAVAEEEARKAHQLWL 571
+ LR ++Q+ E+ R+ +L L
Sbjct: 1247 EAEVSELRAELSSLQTARQEGEQRRRRLELQL 1278
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 72.0 bits (175), Expect = 2e-12
Identities = 123/531 (23%), Positives = 215/531 (40%), Gaps = 87/531 (16%)
Query: 112 SSVSEVMKESKQPASQLQKQKGDTP-----ASATAPTEA---AQIISAAGDTLSVPAPAV 163
S + E M E +Q A +L+ Q G A A A E AQ++ + + + A A
Sbjct: 1123 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1182
Query: 164 QPEESLKT-------DHPEIGE------GKPTPALSEEASSSSIRERPPEEVAARLAQQE 210
+ ES + ++GE G+ L + +R + +EV E
Sbjct: 1183 EDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLE 1242
Query: 211 KQEQVK--------------IESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNIL 256
++ ++ + LA+ LE A R + +A + A V + A + L
Sbjct: 1243 EETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE-AEVSELRAELSSL 1301
Query: 257 KAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKE 316
+ A E + Q + V+G + +A EAA+ L +A+ ELE + + A+ K
Sbjct: 1302 QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1361
Query: 317 VAGAKPHITAAEGKLHNMIVDLDNVVK-------KVQAAQSEAKVVSQYHELVVQARDDF 369
+ +K +++ E +LH+ L + +V+A ++EA + + E AR+
Sbjct: 1362 IRLSK-ELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERA 1420
Query: 370 KRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKAT---- 425
REL + + L W+ + + ++ A R + L + LAE+ T
Sbjct: 1421 GRELQTAQAQ-LSEWRRRQEEEAGALEAGEEAR---RRAAREAEALTQRLAEKTETVDRL 1476
Query: 426 ---------EKQHITLALEKQK-----LEEK-RAFDSAVAKALEHHRSEIQAEQDRKIEE 470
E T+ LE+Q+ LE+K R FD +A E + ++A ++R+ E
Sbjct: 1477 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLA---EEKAAVLRAVEERERAE 1533
Query: 471 VRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEK----LSEQELQFRR 526
+ E E R +A R+ L Q + L++E E LS K S EL+
Sbjct: 1534 A-EGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERAC 1592
Query: 527 LSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALK 577
EQ N LR ++ A E+A+ +L ++V+ALK
Sbjct: 1593 RVAEQAAN----------DLRAQVTELEDELTAAEDAKL--RLEVTVQALK 1631
Score = 40.0 bits (92), Expect = 0.008
Identities = 79/392 (20%), Positives = 155/392 (39%), Gaps = 57/392 (14%)
Query: 200 EEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAA 259
EE RLA ++++ ++ + L + + + + + Q +Q + AH + A
Sbjct: 965 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH-IQELEAHLEAEEGA 1023
Query: 260 MDNSEIAGEKKSAQWRTVEGAL-----------KERRKAVDEAADALLKAKEELEKMKSV 308
++ A+ + E L KER+ D A+ +A EE EK+KS+
Sbjct: 1024 RQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSL 1083
Query: 309 IENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDD 368
+ K E I D+++ ++K + + E +
Sbjct: 1084 NKLRLKYEAT----------------IADMEDRLRKEEKGRQEL--------------EK 1113
Query: 369 FKRELDSITPEVLPGW--KGMSVSDLADKL--STDDLNSLIAHAHRRIDQLNRELAEQKA 424
KR LD + E+ + +L +L ++L + +A A D+ K+
Sbjct: 1114 LKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE---DEGGARAQLLKS 1170
Query: 425 TEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDA--MENEMRTQ 482
+ LA ++ LE +R + K E++A + ++E+ D+ + E+R++
Sbjct: 1171 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRG-ELEDTLDSTNAQQELRSK 1229
Query: 483 LRRQAAAHTDHLRDVLRVQE---QELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDI 539
++ L + R+ E QEL+ Q L E L+EQ Q RR + + L +
Sbjct: 1230 REQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE-LAEQLEQARR-GKGAWEKTRLAL 1287
Query: 540 NTAYARLRGIEQAVQSHAVAEEEARKAHQLWL 571
+ LR ++Q+ E+ R+ +L L
Sbjct: 1288 EAEVSELRAELSSLQTARQEGEQRRRRLELQL 1319
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 70.5 bits (171), Expect = 6e-12
Identities = 134/607 (22%), Positives = 251/607 (41%), Gaps = 78/607 (12%)
Query: 162 AVQPEESLKTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVK-IESL 220
A Q +E+L+ P + + L E+ + S R+ E A++E Q QV+ +E
Sbjct: 811 AEQAQEALEQQLPTLRHERSQ--LQEQLAQLS-RQLSGREQELEQARREAQRQVEALERA 867
Query: 221 AKSLEDALRQTASVTLQAIAAQNAA--VQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVE 278
A+ E ++ A + +Q +AA+ + + K A++ S +++ AQ
Sbjct: 868 AREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ----- 922
Query: 279 GALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDL 338
L+ RR+ ++ ALL AKE L E+AG + I A + K +D
Sbjct: 923 --LEARREQLEAEGQALLLAKETL-----------TGELAGLRQQIIATQEKAS---LDK 966
Query: 339 DNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSV--SDLADKL 396
+ + +K+ A+ EA+ + + R + +L + E W+ + + L +L
Sbjct: 967 ELMAQKLVQAEREAQASLR------EQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQL 1020
Query: 397 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLA------------LEKQKLEEK-- 442
+ L+A ++L+ E+A + + + LA EK L EK
Sbjct: 1021 QREQ-EELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLM 1079
Query: 443 --RAFDSAVAKALEHHRSEIQA--EQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVL 498
R + ++ +E + + Q+ EQDR + ++R Q AAAH +R
Sbjct: 1080 GTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVR--- 1136
Query: 499 RVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQA--VQSH 556
R+QEQ +++ + +E+ RL ++ D ++ A +LR ++ VQ
Sbjct: 1137 RLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQ 1196
Query: 557 AVAE------EEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQ 610
E E A++ L S E L+ ++K + +E ++ L + + K + T
Sbjct: 1197 EAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEART- 1255
Query: 611 ALTAAIPPESLTRGVYSEETLRARFYA---VQKLARRVAMIDETRNSLYQYFLSYLQSLL 667
A+ E+ +E R+R A +Q+L R++ M+D L + L
Sbjct: 1256 ----AVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLA 1311
Query: 668 LFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESR---RVAQDW 724
L + + E + L AS + +L++A + + + +GE R R
Sbjct: 1312 LGERAEKESRRETL--GLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGS 1369
Query: 725 LKEARMT 731
L+EAR T
Sbjct: 1370 LEEARGT 1376
Score = 50.4 bits (119), Expect = 6e-06
Identities = 98/434 (22%), Positives = 172/434 (39%), Gaps = 68/434 (15%)
Query: 186 SEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAA 245
+E A S +R EE+ ARL ++++ +I +L + ++ L S QA++ + +
Sbjct: 1011 AERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESE 1070
Query: 246 VQAVNAH--SNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELE 303
A++ A + E+ +K+ AQ R++ +AL +L
Sbjct: 1071 KTALSEKLMGTRHSLATISLEMERQKRDAQ---------SRQEQDRSTVNALTSELRDLR 1121
Query: 304 KMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVV 363
+ A +EV +L DL K+ + EA+ + L+
Sbjct: 1122 AQREEAAAAHAQEVR-----------RLQEQARDLG---KQRDSCLREAEELRTQLRLLE 1167
Query: 364 QARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAE-- 421
ARD +REL ++ +G V + +L + + + L R E
Sbjct: 1168 DARDGLRRELLEAQRKLRESQEGREV----QRQEAGELRRSLGEGAKEREALRRSNEELR 1223
Query: 422 --QKATEKQHITLALEKQKLEEKRAF----DSAVAKALEHHRSEIQ------AEQDRKIE 469
K E + I+L L + E+K A +AV K R+ +Q E R+++
Sbjct: 1224 SAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQ 1283
Query: 470 EVRDAME--NEMRTQLRRQAA-----------AHTDHLRDVLRVQEQELKSEFEQNLSEK 516
E+R M+ + T+L R+ A A + R+ L ++++ LK E S +
Sbjct: 1284 ELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGE----ASLE 1339
Query: 517 LSEQELQF-RRLSQEQVDNFTLDINTAYARL---RGIEQAVQSHAVAEEEARKAHQLWLS 572
+ QELQ +R QEQ F L RG E+ HA E +A +
Sbjct: 1340 VMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAAR---- 1395
Query: 573 VEALKYSMKTSSAE 586
EA + ++ S+AE
Sbjct: 1396 AEAAELGLRLSAAE 1409
Score = 46.2 bits (108), Expect = 1e-04
Identities = 63/323 (19%), Positives = 137/323 (42%), Gaps = 39/323 (12%)
Query: 255 ILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKK 314
++ +A+ ++ + ++ + L RK + ++ +E+L++++ + A +
Sbjct: 523 LIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQ 582
Query: 315 KEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELD 374
A+ + + + N+ +Q AQ +A+ + Q E + A+++ +R+ D
Sbjct: 583 AH-EDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRD 641
Query: 375 SITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLAL 434
+ E + +V D A + + +HR+++QL E + LA
Sbjct: 642 RLEEE-----QEDAVQDGAR------VRRELERSHRQLEQL----------EGKRSVLAK 680
Query: 435 EKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHL 494
E ++ E + + L+ ++E+ AE K E R +E M T+LR + A+ D L
Sbjct: 681 ELVEVREALSRATLQRDMLQAEKAEV-AEALTKAEAGRVELELSM-TKLRAEEASLQDSL 738
Query: 495 RDVLRVQEQ---------ELKSEFEQNLS-----EKLSEQELQFRRLSQEQVDNFTLDIN 540
+ + E L ++ E+ S ++ +EQE R QE+++ L+
Sbjct: 739 SKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQE 798
Query: 541 TAYARLRG-IEQAVQSHAVAEEE 562
A L G + A Q+ E++
Sbjct: 799 VARQGLEGSLRVAEQAQEALEQQ 821
Score = 38.9 bits (89), Expect = 0.018
Identities = 57/297 (19%), Positives = 125/297 (42%), Gaps = 30/297 (10%)
Query: 216 KIESLAKSLEDALRQTASVTLQAIAAQNA----------AVQAVNAHSNILKAAMDNSEI 265
K+E +L D +R Q+ A+ N+ A+ A +L+ +D +
Sbjct: 1716 KVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQ 1775
Query: 266 AGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHIT 325
A + Q ++ ++ R V + ++A+ +L++++ V+ ++ E A +
Sbjct: 1776 ALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNT-VQ 1834
Query: 326 AAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWK 385
+ + + L ++ + + ++E + V + + + R +R LD + E L +
Sbjct: 1835 KLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHE 1894
Query: 386 GMSVSDLADKLSTD----DLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALE------ 435
+V A+K D +A A R+I QL ++ E+ H LE
Sbjct: 1895 D-TVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVV---VLEQSHSPAQLEVDAQQQ 1950
Query: 436 ----KQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAA 488
+Q++E R+ + + LE R ++ R +EE ++ +++ +LRR +A
Sbjct: 1951 QLELQQEVERLRSAQAQTERTLEA-RERAHRQRVRGLEEQVSTLKGQLQQELRRSSA 2006
Score = 38.5 bits (88), Expect = 0.023
Identities = 85/455 (18%), Positives = 176/455 (38%), Gaps = 55/455 (12%)
Query: 109 LKISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGD-TLSVPAPAVQPEE 167
L++ + + S+ L+KQ D+ + A E Q + D + A + +
Sbjct: 533 LQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQ 592
Query: 168 SLKTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDA 227
L++ + + K A S + + E E + AQ+E + Q + L + EDA
Sbjct: 593 RLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQR--DRLEEEQEDA 650
Query: 228 LRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKA 287
++ A V + + Q S + K E+ +++ T++ + + KA
Sbjct: 651 VQDGARVRRELERSHRQLEQLEGKRSVLAK------ELVEVREALSRATLQRDMLQAEKA 704
Query: 288 VDEAADALLKAKE---ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKK 344
E A+AL KA+ ELE + + A++ + + ++A L +DL+ +V +
Sbjct: 705 --EVAEALTKAEAGRVELELSMTKLR-AEEASLQDSLSKLSALNESLAQDKLDLNRLVAQ 761
Query: 345 VQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSL 404
++ +S + + E + + L+ + E +G+ S
Sbjct: 762 LEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGS-------------- 807
Query: 405 IAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQ 464
L Q+A E+Q TL E+ +L+E+ A S E + + E
Sbjct: 808 ----------LRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREA 857
Query: 465 DRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQF 524
R++E + A R + A +H +++ E + + LSE+ +
Sbjct: 858 QRQVEALERA--------AREKEALAKEHAGLAVQLVAAEREG---RTLSEEATR----- 901
Query: 525 RRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVA 559
RL +E ++ ++ A+L + +++ A
Sbjct: 902 LRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQA 936
Score = 32.3 bits (72), Expect = 1.7
Identities = 72/393 (18%), Positives = 158/393 (40%), Gaps = 72/393 (18%)
Query: 200 EEVAARLAQQEKQEQVKIESLAKSLEDALR---------QTASVTLQAIAAQNAAVQAVN 250
E++ A+ + + +K ++++ LE ALR + + Q++ + +
Sbjct: 94 EDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQA 153
Query: 251 AHSNILKAAMDNSEIAGEKKSAQW-RTVEGALKERRKAVDEAADALLKAKEELEKMKSVI 309
++ L+A + G+++ AQ + ++G + + +K E LL+ ELE+ + +
Sbjct: 154 SYRRKLQAYQE-----GQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQR--L 206
Query: 310 ENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDF 369
+ + + DL++ + +++ Q + ++Q + ++
Sbjct: 207 RDTEHSQ--------------------DLESALIRLEEEQQRSASLAQVNAML------- 239
Query: 370 KRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQH 429
+ +LD G ++S+ K++ D HR E + +H
Sbjct: 240 REQLDQA------GSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEH 293
Query: 430 ITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDA----------MENEM 479
L L +++ R S V E ++ E R V++A E+
Sbjct: 294 SRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRA 353
Query: 480 RTQLRRQA---AAHTDHLRD-VLR---VQEQELKSEFEQ-NLSEKLSEQELQFRRLSQEQ 531
L +QA A + LRD VLR + +Q+++S+ ++ +LS +++E L +RL ++
Sbjct: 354 EAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQN 413
Query: 532 V--DNFTLDINTAYARLRGIEQAVQSHAVAEEE 562
+ D D+ L + +Q A E E
Sbjct: 414 LEKDQVNKDLTEKLEALESLR--LQEQAALETE 444
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 65.5 bits (158), Expect = 2e-10
Identities = 98/487 (20%), Positives = 203/487 (41%), Gaps = 62/487 (12%)
Query: 111 ISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLK 170
+ ++E +KES +LQ + + AS + + + + L + E K
Sbjct: 145 VKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTK 204
Query: 171 TDHP-EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALR 229
TD +G K L + + E EEV+ RL +Q + E L K +ED L
Sbjct: 205 TDELLALGREKGNEILELKCNL----ENKKEEVS-RLEEQMNGLKTSNEHLQKHVEDLLT 259
Query: 230 QTASVTLQAIAAQNAAVQAVNAH---SNILKAAMDNSEIAGEKKSAQWRTVEGALKERRK 286
+ Q + + +NAH SN+ K+A D+SE + + + LKE +
Sbjct: 260 KLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGE 319
Query: 287 AVDEAADALLKAKEELEKM-KSVIENAKK--KEVAGAKPHITAAEGKLHNMIVDLDNVVK 343
A D LL+ ++ ++M K ++E + KE+ A ++A + K I+ + +
Sbjct: 320 ANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRK--GAILSEEELAA 377
Query: 344 KVQAAQSEAKVV------SQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLS 397
A + AK+V ++ + V+ +D + + L +K
Sbjct: 378 MSPTAAAVAKIVKPGMKLTELYNAYVETQDQ------------------LLLEKLENKRI 419
Query: 398 TDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALE-KQKLEEKRAFDSAVAKALEHH 456
L+ ++ + L R+ E + +K +L+++ +Q ++E + KA +
Sbjct: 420 NKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NK 477
Query: 457 RSEIQAEQDRKIE-EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSE 515
+S + +R++E +V+D + ++R L A +H+ ++++E+ S + SE
Sbjct: 478 QSSVLERDNRRMEIQVKD-LSQQIRVLLMELEEARGNHV-----IRDEEVSSADISSSSE 531
Query: 516 KLSEQELQFRRLSQEQVDNFTL--------------DINTAYARLRGIEQAVQSHAVAEE 561
+S+ + +R + + Q N L + T +++ ++ ++S E
Sbjct: 532 VISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELE 591
Query: 562 EARKAHQ 568
+ RK+ Q
Sbjct: 592 QLRKSRQ 598
Score = 53.5 bits (127), Expect = 7e-07
Identities = 86/399 (21%), Positives = 167/399 (41%), Gaps = 54/399 (13%)
Query: 195 RERPPEEVAA----RLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVN 250
RER +E + L + + ++E L KS + ++ S+ Q + Q
Sbjct: 564 REREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTG 623
Query: 251 AHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIE 310
+ +++D+ +A K T + V E+ +A+ +AK L++++ + E
Sbjct: 624 VAIPLHASSLDDVSLASTPKRPS--TSQTVSTPAPVPVIESTEAI-EAKAALKQLQEIFE 680
Query: 311 NAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFK 370
N KK++ K E KL + DL + K+ ++ S+ +E++ + ++
Sbjct: 681 NYKKEKAENEKIQNEQLE-KLQEQVTDLRSQNTKI---STQLDFASKRYEMLQDNVEGYR 736
Query: 371 RELDSITPEVLPGWKGMSVSDLADKLSTDDL---NSLIAHAHRRIDQLNRE--------- 418
RE+ S+ + T DL N +A A R + L +E
Sbjct: 737 REITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEV 796
Query: 419 ---------LAEQKA-----TEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQ 464
LAEQ+ T Q I LE+ + E K+ S + K LEH S ++ +
Sbjct: 797 RLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEK-LEHEISHLKKKL 855
Query: 465 DRKIEEVRDAMENEMRTQL---RRQAAAHTD-HL--RDVLRVQEQELKSEFEQNLSEKLS 518
+ ++E+ R + + QL +RQ T+ HL +++L+ ++E+ + L + LS
Sbjct: 856 ENEVEQ-RHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIAT-----LKQHLS 909
Query: 519 EQELQFRRLSQEQV----DNFTLDINTAYARLRGIEQAV 553
E+Q S ++ + D++ ++LR E+ V
Sbjct: 910 NMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQV 948
Score = 52.0 bits (123), Expect = 2e-06
Identities = 97/456 (21%), Positives = 181/456 (39%), Gaps = 66/456 (14%)
Query: 207 AQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIA 266
A+++ QEQ KI A++ + L AA A+QA + + + + E
Sbjct: 1064 ARRDCQEQAKIAVEAQNKYER-------ELMLHAADVEALQAAKEQVSKMASVRQHLEET 1116
Query: 267 GEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSV----IENAKKKEVAGAKP 322
+K +Q + + +ER + + + + E+LEK + IE K VA K
Sbjct: 1117 TQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKE 1176
Query: 323 HI-------TAAEGKLHNMIVDLDNVVK--------KVQAAQSEAKVVSQYHELVVQARD 367
+ + EGK I+++ ++ + + AQ E+ Q EL+ +
Sbjct: 1177 GVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQ 1236
Query: 368 DFKRELDSITPEVLPGWKGMSV-SDLADKLSTDDL----NSLIAHAHRRIDQ-LNRELAE 421
+ + L++ +V K M+ +L K T ++ N ++ R++Q L + A+
Sbjct: 1237 ELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAK 1296
Query: 422 QKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRT 481
+ E + L +L EK A K LE +A + + +D E R
Sbjct: 1297 VRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYR- 1355
Query: 482 QLRRQAAAHTDHLRDVLRVQEQELKSEF---------EQNLSEKLSEQELQFR---RLSQ 529
+L + HT ++ L + LK+E QNL + L E + R Q
Sbjct: 1356 KLLSEKEVHTKRIQQ-LTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQ 1414
Query: 530 EQVDNFTLDI-----------------NTAYARLRGIEQAV-QSHAVAEEEARKAHQLWL 571
+ +D +DI T Y L+ + V ++ A + + ++ H
Sbjct: 1415 KDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQ 1474
Query: 572 SVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNE 607
++ LK ++ + AET + L S VE ++ S+ E
Sbjct: 1475 EMQELKETL--NQAETKSKSLESQVENLQKTLSEKE 1508
Score = 48.5 bits (114), Expect = 2e-05
Identities = 120/575 (20%), Positives = 227/575 (39%), Gaps = 100/575 (17%)
Query: 66 KWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKESKQPA 125
K + F+ +EK + +K + + + ++ + +SSV ++E+ Q A
Sbjct: 995 KESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRA 1054
Query: 126 SQL----QKQKGDTPASATAPTEAA-----QIISAAGDTLSVPAPAVQPEESLKT-DHPE 175
S Q+ + D A EA +++ A D ++ A Q + H E
Sbjct: 1055 STALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLE 1114
Query: 176 IGEGKPTPALSEEASSSSIRERP-PEEVA---ARLAQQEKQEQV---KIESLAKSLEDAL 228
K L E +S RER +EV+ R EKQ ++ +IE L+ + ++
Sbjct: 1115 ETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASV 1174
Query: 229 RQTASVTLQAIAAQNAAVQA--------VNAHSNILKAAMDNSEIAG-------EKKSAQ 273
++ L ++ Q + I + + +++ E +
Sbjct: 1175 KEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERE 1234
Query: 274 WRTVEGALKERRKAVDEAADALLKAKEELEK---MKSVIENAK--KKEVAGAKPHITAAE 328
+ ++ +L R+ V A + + +E ++K M V+E K ++E + + +
Sbjct: 1235 LQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQ 1294
Query: 329 GKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMS 388
K+ + +D+ +++ A SE + Q + +++ +D KR WK +
Sbjct: 1295 AKVRKLELDI-LPLQEANAELSEKSGMLQAEKKLLE--EDVKR------------WKARN 1339
Query: 389 ---VSDLADKLSTDDLNSLIAHAH---RRIDQLNRELAEQKA---------TEKQHITLA 433
VS D T++ L++ +RI QL E+ KA T Q++ +
Sbjct: 1340 QHLVSQQKDP-DTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQS 1398
Query: 434 LEKQKLEEKRAFDSAVAKALEHHRSEIQAE-----QDRKIEEVRDAMENEMRTQ----LR 484
L K+ L + R + K L+ +IQ + Q +KI E++ Q +
Sbjct: 1399 L-KEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVME 1457
Query: 485 RQAAAHTDHLRDVLRVQE-QELKSEFEQ-------------NLSEKLSEQELQFRRLSQE 530
A + DH + VQE QELK Q NL + LSE+E + R L ++
Sbjct: 1458 TSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQ 1517
Query: 531 QVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARK 565
T+ + + +RLR Q +Q EE+ R+
Sbjct: 1518 -----TVQLQSELSRLR---QDLQDRTTQEEQLRQ 1544
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 63.5 bits (153), Expect = 7e-10
Identities = 112/543 (20%), Positives = 203/543 (37%), Gaps = 63/543 (11%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPE 175
E+ + +Q S L + +G+ A+ A EA + A + V+ E LK E
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123
Query: 176 IGEGKP-----TPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQ 230
+ + L +EA + R E+ A R Q++ ++E K E LRQ
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR---QKQAADAEMEKHKKFAEQTLRQ 2180
Query: 231 TASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 290
A V Q + ++ + N+L + + + + Q R V+E
Sbjct: 2181 KAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-----------RSQVEE 2228
Query: 291 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQS 350
++ EEL K+K+ IE + + + D DN + +Q
Sbjct: 2229 ELFSVRVQMEELSKLKARIEAENRALI-----------------LRDKDNTQRFLQEEAE 2271
Query: 351 EAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHAH 409
+ K V++ + A + R L + E L + ++ L +K+ + + L A A
Sbjct: 2272 KMKQVAEEAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2330
Query: 410 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 469
+ Q +ELA+++A Q + +Q EE + F ++AE+ R++E
Sbjct: 2331 --LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQLE 2377
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQFR 525
+A ++R +A A + R Q +E+ + + +L+ QE +Q
Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTL 2434
Query: 526 RLSQEQVDNFTLDINTAYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSMK 581
+ ++Q D+ + A A L ++ +Q A + EE + Q L E
Sbjct: 2435 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2494
Query: 582 TSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKL 641
S + + +E KA + A E R E R R A +
Sbjct: 2495 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2554
Query: 642 ARR 644
ARR
Sbjct: 2555 ARR 2557
Score = 61.6 bits (148), Expect = 3e-09
Identities = 114/521 (21%), Positives = 204/521 (39%), Gaps = 90/521 (17%)
Query: 110 KISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESL 169
++ +++E K +Q A + ++ A A A+ ++A G+ + A E +L
Sbjct: 1805 RLRALAEEAKRQRQLAEEDAARQ-----RAEAERVLAEKLAAIGEATRLKTEA---EIAL 1856
Query: 170 KTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAA--------RLAQQEKQEQVKIESLA 221
K E L A + + R EE AA RLAQ K ++E
Sbjct: 1857 KEKEAE------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1910
Query: 222 KSLEDALRQTASVTLQAIAAQNAAVQAV---------------NAHSNILKAAMDNSEIA 266
+ED LRQ V + +A + + +A NA + E A
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970
Query: 267 GEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAK-------- 313
+++ A + R E +++ A +EAA A EE+E++K+ +E A+
Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2030
Query: 314 --------------KKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYH 359
K+ A K H A + K + L + + EA+ +
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Query: 360 ELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL--STDDLNSLIAHAHRRIDQLNR 417
E +AR +RE +V + A++L S ++ A A ++L +
Sbjct: 2091 EEAEEARVQAEREAAQSRRQV----------EEAERLKQSAEEQAQARAQAQAAAEKLRK 2140
Query: 418 ELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----ALEHHRSEIQAEQD----RKIE 469
E AEQ+A + E+ L +K+A D+ + K A + R + Q EQ+ R
Sbjct: 2141 E-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFE-QNLSEKLSEQELQFRRLS 528
E D +N + +L+R A T+ R +V+E+ + + LS+ + E + R L
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2255
Query: 529 QEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 569
DN + +++ + + +VA +EA + QL
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296
Score = 60.8 bits (146), Expect = 4e-09
Identities = 118/586 (20%), Positives = 225/586 (38%), Gaps = 80/586 (13%)
Query: 111 ISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAA---GDTLSVPAPAVQPEE 167
+ ++ E+ ++++ +L++ + + E AQ + A S Q E
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1594
Query: 168 SLKTDHPEIGEGKPTPA--LSEEASSSSIRERPPEEV----------------AARLAQQ 209
SL+ +H + + + ++A + RE E+ A +AQQ
Sbjct: 1595 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 210 EKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK 269
+ Q + E + E R+ QA+ + E+A ++
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------ELAEQE 1693
Query: 270 KSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKPHITA 326
Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752
Query: 327 AEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKG 386
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1753 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL------ 1806
Query: 387 MSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKR 443
++++ A + L+ +D A A R + + + E K +AL++++ E +R
Sbjct: 1807 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENER 1865
Query: 444 AFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQE 502
A +A + R E QA Q + IEE + ++L RQ D LR +V+E
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925
Query: 503 Q--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------YARLR 547
+ LK+ FE+ + K +E EL+ R+ D ++ A R R
Sbjct: 1926 EILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1984
Query: 548 GIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAVEAIK 600
E+ VQ AEEEA + + L VE LK ++ + + L A EA +
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2044
Query: 601 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 646
E A + L + + E+++ + + ARR A
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Score = 56.6 bits (135), Expect = 8e-08
Identities = 87/400 (21%), Positives = 165/400 (41%), Gaps = 78/400 (19%)
Query: 175 EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 234
++ E E + +++R EEV R +Q K S+ + L+ LRQ++
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEA 1431
Query: 235 TLQAIAAQNAAVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 290
+QA A Q A + + +++ ++ +E Q EG L+ R +E
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEE 1484
Query: 291 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQ 349
A +A+EE E+++ +++ +++ V+L + VK + +AA+
Sbjct: 1485 AEAQKRQAQEEAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAR 1529
Query: 350 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAH 409
+ + + EL +QA + +R + EV + + A + + +L S A
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFA 1586
Query: 410 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 469
+ QL R L E+ H+ +A +++ E R++ QAE +R E
Sbjct: 1587 EKTAQLERSLQEE------HVAVAQLREEAER---------------RAQQQAEAERARE 1625
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQ 529
E +E R QL+ A LR+Q +E+ + + L++ E + ++
Sbjct: 1626 EAERELE---RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEA 1669
Query: 530 EQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 569
E+ A R + EQAV+ +AE+E K QL
Sbjct: 1670 ER---------EARRRGKAEEQAVRQRELAEQELEKQRQL 1700
Score = 47.0 bits (110), Expect = 7e-05
Identities = 118/580 (20%), Positives = 229/580 (39%), Gaps = 79/580 (13%)
Query: 109 LKISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEES 168
L++ E +E Q ++ QK + + A++ + A L++P P+ P
Sbjct: 1007 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG---VARLSAEAEKVLALPEPS--PAAP 1061
Query: 169 LKTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDAL 228
E+ GK L + S S+I + ++ + + E+V + + + L++A
Sbjct: 1062 TLRSELELTLGK----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQLKEA- 1115
Query: 229 RQTASVTLQAIAAQNAAVQAVNAHSNILKAAMD--NSEIAGEKKSAQ------------- 273
Q TL + A A+++ + A + + D E+ G ++ +
Sbjct: 1116 -QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1174
Query: 274 --WRTVEGALKERRKAVDEAADALLKAKEEL-----------EKMKSVIENAKKK-EVAG 319
WR L ER +AV D + E+L + + + +++A+++ E
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234
Query: 320 AKP--HITAAEGKLHN---MIVDLDNVVKKVQAAQSEAK----VVSQYHELVVQARDDFK 370
A P A +L ++ +++ +KV+ Q AK + Y +V +K
Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT----YK 1290
Query: 371 RELDSIT-----PEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKAT 425
+L+ + P+V G + + + + +L +L + + I + R + E++
Sbjct: 1291 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1350
Query: 426 EKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ--- 482
+Q A E+++L E A ALE R +A K + R+A E + R Q
Sbjct: 1351 AEQQ--RAEERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 483 -LRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDI 539
R +AA + ++ + Q+L+ E + K + E + R +E++ L +
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 540 NTAYARLRGIEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAV 596
+ G E +Q+ A AEE + Q E L+ ++ S + L S V
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1521
Query: 597 EA-IKANCSDNEFTQAL-TAAIPPESLTRGVYSEETLRAR 634
+A +A QAL + E R + E RAR
Sbjct: 1522 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Score = 41.6 bits (96), Expect = 0.003
Identities = 77/357 (21%), Positives = 149/357 (41%), Gaps = 51/357 (14%)
Query: 178 EGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTL 236
E + ++EEA+ S+ + AARL Q +++ + +LA K L++ ++ T
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 237 QAIAAQNAAVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAAD 293
A+ Q A + D ++A E+ RT+E ER++ ++ +A+
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAE 2381
Query: 294 ALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQS 350
A E L+ + + A+ + A+ AE KLH + V VQ +
Sbjct: 2382 A-----ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 351 EAKVVSQYHELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDL 392
+ + E + +A + +RE + + E +L + + S L
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 393 ADKLSTDDLNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAV 449
++K S I +++QL ++ A+Q E+Q ++Q++E++R V
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLV 2549
Query: 450 AKALEHHRSEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 504
A E R + +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2604
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 63.5 bits (153), Expect = 7e-10
Identities = 112/543 (20%), Positives = 203/543 (37%), Gaps = 63/543 (11%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPE 175
E+ + +Q S L + +G+ A+ A EA + A + V+ E LK E
Sbjct: 2068 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2127
Query: 176 IGEGKP-----TPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQ 230
+ + L +EA + R E+ A R Q++ ++E K E LRQ
Sbjct: 2128 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR---QKQAADAEMEKHKKFAEQTLRQ 2184
Query: 231 TASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 290
A V Q + ++ + N+L + + + + Q R V+E
Sbjct: 2185 KAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-----------RSQVEE 2232
Query: 291 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQS 350
++ EEL K+K+ IE + + + D DN + +Q
Sbjct: 2233 ELFSVRVQMEELSKLKARIEAENRALI-----------------LRDKDNTQRFLQEEAE 2275
Query: 351 EAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHAH 409
+ K V++ + A + R L + E L + ++ L +K+ + + L A A
Sbjct: 2276 KMKQVAEEAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2334
Query: 410 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 469
+ Q +ELA+++A Q + +Q EE + F ++AE+ R++E
Sbjct: 2335 --LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQLE 2381
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQFR 525
+A ++R +A A + R Q +E+ + + +L+ QE +Q
Sbjct: 2382 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTL 2438
Query: 526 RLSQEQVDNFTLDINTAYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSMK 581
+ ++Q D+ + A A L ++ +Q A + EE + Q L E
Sbjct: 2439 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2498
Query: 582 TSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKL 641
S + + +E KA + A E R E R R A +
Sbjct: 2499 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2558
Query: 642 ARR 644
ARR
Sbjct: 2559 ARR 2561
Score = 61.6 bits (148), Expect = 3e-09
Identities = 114/521 (21%), Positives = 204/521 (39%), Gaps = 90/521 (17%)
Query: 110 KISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESL 169
++ +++E K +Q A + ++ A A A+ ++A G+ + A E +L
Sbjct: 1809 RLRALAEEAKRQRQLAEEDAARQ-----RAEAERVLAEKLAAIGEATRLKTEA---EIAL 1860
Query: 170 KTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAA--------RLAQQEKQEQVKIESLA 221
K E L A + + R EE AA RLAQ K ++E
Sbjct: 1861 KEKEAE------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1914
Query: 222 KSLEDALRQTASVTLQAIAAQNAAVQAV---------------NAHSNILKAAMDNSEIA 266
+ED LRQ V + +A + + +A NA + E A
Sbjct: 1915 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1974
Query: 267 GEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAK-------- 313
+++ A + R E +++ A +EAA A EE+E++K+ +E A+
Sbjct: 1975 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2034
Query: 314 --------------KKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYH 359
K+ A K H A + K + L + + EA+ +
Sbjct: 2035 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2094
Query: 360 ELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL--STDDLNSLIAHAHRRIDQLNR 417
E +AR +RE +V + A++L S ++ A A ++L +
Sbjct: 2095 EEAEEARVQAEREAAQSRRQV----------EEAERLKQSAEEQAQARAQAQAAAEKLRK 2144
Query: 418 ELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----ALEHHRSEIQAEQD----RKIE 469
E AEQ+A + E+ L +K+A D+ + K A + R + Q EQ+ R
Sbjct: 2145 E-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2199
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFE-QNLSEKLSEQELQFRRLS 528
E D +N + +L+R A T+ R +V+E+ + + LS+ + E + R L
Sbjct: 2200 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2259
Query: 529 QEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 569
DN + +++ + + +VA +EA + QL
Sbjct: 2260 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2300
Score = 60.8 bits (146), Expect = 4e-09
Identities = 118/586 (20%), Positives = 225/586 (38%), Gaps = 80/586 (13%)
Query: 111 ISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAA---GDTLSVPAPAVQPEE 167
+ ++ E+ ++++ +L++ + + E AQ + A S Q E
Sbjct: 1539 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1598
Query: 168 SLKTDHPEIGEGKPTPA--LSEEASSSSIRERPPEEV----------------AARLAQQ 209
SL+ +H + + + ++A + RE E+ A +AQQ
Sbjct: 1599 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1658
Query: 210 EKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK 269
+ Q + E + E R+ QA+ + E+A ++
Sbjct: 1659 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------ELAEQE 1697
Query: 270 KSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKPHITA 326
Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1698 LEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1756
Query: 327 AEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKG 386
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1757 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL------ 1810
Query: 387 MSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKR 443
++++ A + L+ +D A A R + + + E K +AL++++ E +R
Sbjct: 1811 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENER 1869
Query: 444 AFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQE 502
A +A + R E QA Q + IEE + ++L RQ D LR +V+E
Sbjct: 1870 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1929
Query: 503 Q--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------YARLR 547
+ LK+ FE+ + K +E EL+ R+ D ++ A R R
Sbjct: 1930 EILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1988
Query: 548 GIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAVEAIK 600
E+ VQ AEEEA + + L VE LK ++ + + L A EA +
Sbjct: 1989 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2048
Query: 601 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 646
E A + L + + E+++ + + ARR A
Sbjct: 2049 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2094
Score = 56.6 bits (135), Expect = 8e-08
Identities = 87/400 (21%), Positives = 165/400 (41%), Gaps = 78/400 (19%)
Query: 175 EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 234
++ E E + +++R EEV R +Q K S+ + L+ LRQ++
Sbjct: 1378 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEA 1435
Query: 235 TLQAIAAQNAAVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 290
+QA A Q A + + +++ ++ +E Q EG L+ R +E
Sbjct: 1436 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEE 1488
Query: 291 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQ 349
A +A+EE E+++ +++ +++ V+L + VK + +AA+
Sbjct: 1489 AEAQKRQAQEEAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAR 1533
Query: 350 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAH 409
+ + + EL +QA + +R + EV + + A + + +L S A
Sbjct: 1534 EKQRALQALEELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFA 1590
Query: 410 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 469
+ QL R L E+ H+ +A +++ E R++ QAE +R E
Sbjct: 1591 EKTAQLERSLQEE------HVAVAQLREEAER---------------RAQQQAEAERARE 1629
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQ 529
E +E R QL+ A LR+Q +E+ + + L++ E + ++
Sbjct: 1630 EAERELE---RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEA 1673
Query: 530 EQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 569
E+ A R + EQAV+ +AE+E K QL
Sbjct: 1674 ER---------EARRRGKAEEQAVRQRELAEQELEKQRQL 1704
Score = 47.0 bits (110), Expect = 7e-05
Identities = 118/580 (20%), Positives = 229/580 (39%), Gaps = 79/580 (13%)
Query: 109 LKISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEES 168
L++ E +E Q ++ QK + + A++ + A L++P P+ P
Sbjct: 1011 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG---VARLSAEAEKVLALPEPS--PAAP 1065
Query: 169 LKTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDAL 228
E+ GK L + S S+I + ++ + + E+V + + + L++A
Sbjct: 1066 TLRSELELTLGK----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQLKEA- 1119
Query: 229 RQTASVTLQAIAAQNAAVQAVNAHSNILKAAMD--NSEIAGEKKSAQ------------- 273
Q TL + A A+++ + A + + D E+ G ++ +
Sbjct: 1120 -QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1178
Query: 274 --WRTVEGALKERRKAVDEAADALLKAKEEL-----------EKMKSVIENAKKK-EVAG 319
WR L ER +AV D + E+L + + + +++A+++ E
Sbjct: 1179 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1238
Query: 320 AKP--HITAAEGKLHN---MIVDLDNVVKKVQAAQSEAK----VVSQYHELVVQARDDFK 370
A P A +L ++ +++ +KV+ Q AK + Y +V +K
Sbjct: 1239 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT----YK 1294
Query: 371 RELDSIT-----PEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKAT 425
+L+ + P+V G + + + + +L +L + + I + R + E++
Sbjct: 1295 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1354
Query: 426 EKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ--- 482
+Q A E+++L E A ALE R +A K + R+A E + R Q
Sbjct: 1355 AEQQ--RAEERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1405
Query: 483 -LRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDI 539
R +AA + ++ + Q+L+ E + K + E + R +E++ L +
Sbjct: 1406 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1465
Query: 540 NTAYARLRGIEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAV 596
+ G E +Q+ A AEE + Q E L+ ++ S + L S V
Sbjct: 1466 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1525
Query: 597 EA-IKANCSDNEFTQAL-TAAIPPESLTRGVYSEETLRAR 634
+A +A QAL + E R + E RAR
Sbjct: 1526 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1565
Score = 41.6 bits (96), Expect = 0.003
Identities = 77/357 (21%), Positives = 149/357 (41%), Gaps = 51/357 (14%)
Query: 178 EGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTL 236
E + ++EEA+ S+ + AARL Q +++ + +LA K L++ ++ T
Sbjct: 2273 EAEKMKQVAEEAARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328
Query: 237 QAIAAQNAAVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAAD 293
A+ Q A + D ++A E+ RT+E ER++ ++ +A+
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAE 2385
Query: 294 ALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQS 350
A E L+ + + A+ + A+ AE KLH + V VQ +
Sbjct: 2386 A-----ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2440
Query: 351 EAKVVSQYHELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDL 392
+ + E + +A + +RE + + E +L + + S L
Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2500
Query: 393 ADKLSTDDLNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAV 449
++K S I +++QL ++ A+Q E+Q ++Q++E++R V
Sbjct: 2501 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLV 2553
Query: 450 AKALEHHRSEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 504
A E R + +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2554 ASMEEARRRQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2608
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 63.5 bits (153), Expect = 7e-10
Identities = 112/543 (20%), Positives = 203/543 (37%), Gaps = 63/543 (11%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPE 175
E+ + +Q S L + +G+ A+ A EA + A + V+ E LK E
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123
Query: 176 IGEGKP-----TPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQ 230
+ + L +EA + R E+ A R Q++ ++E K E LRQ
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR---QKQAADAEMEKHKKFAEQTLRQ 2180
Query: 231 TASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 290
A V Q + ++ + N+L + + + + Q R V+E
Sbjct: 2181 KAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-----------RSQVEE 2228
Query: 291 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQS 350
++ EEL K+K+ IE + + + D DN + +Q
Sbjct: 2229 ELFSVRVQMEELSKLKARIEAENRALI-----------------LRDKDNTQRFLQEEAE 2271
Query: 351 EAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHAH 409
+ K V++ + A + R L + E L + ++ L +K+ + + L A A
Sbjct: 2272 KMKQVAEEAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2330
Query: 410 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 469
+ Q +ELA+++A Q + +Q EE + F ++AE+ R++E
Sbjct: 2331 --LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQLE 2377
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQFR 525
+A ++R +A A + R Q +E+ + + +L+ QE +Q
Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTL 2434
Query: 526 RLSQEQVDNFTLDINTAYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSMK 581
+ ++Q D+ + A A L ++ +Q A + EE + Q L E
Sbjct: 2435 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2494
Query: 582 TSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKL 641
S + + +E KA + A E R E R R A +
Sbjct: 2495 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2554
Query: 642 ARR 644
ARR
Sbjct: 2555 ARR 2557
Score = 61.6 bits (148), Expect = 3e-09
Identities = 114/521 (21%), Positives = 204/521 (39%), Gaps = 90/521 (17%)
Query: 110 KISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESL 169
++ +++E K +Q A + ++ A A A+ ++A G+ + A E +L
Sbjct: 1805 RLRALAEEAKRQRQLAEEDAARQ-----RAEAERVLAEKLAAIGEATRLKTEA---EIAL 1856
Query: 170 KTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAA--------RLAQQEKQEQVKIESLA 221
K E L A + + R EE AA RLAQ K ++E
Sbjct: 1857 KEKEAE------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1910
Query: 222 KSLEDALRQTASVTLQAIAAQNAAVQAV---------------NAHSNILKAAMDNSEIA 266
+ED LRQ V + +A + + +A NA + E A
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970
Query: 267 GEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAK-------- 313
+++ A + R E +++ A +EAA A EE+E++K+ +E A+
Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2030
Query: 314 --------------KKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYH 359
K+ A K H A + K + L + + EA+ +
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Query: 360 ELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL--STDDLNSLIAHAHRRIDQLNR 417
E +AR +RE +V + A++L S ++ A A ++L +
Sbjct: 2091 EEAEEARVQAEREAAQSRRQV----------EEAERLKQSAEEQAQARAQAQAAAEKLRK 2140
Query: 418 ELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----ALEHHRSEIQAEQD----RKIE 469
E AEQ+A + E+ L +K+A D+ + K A + R + Q EQ+ R
Sbjct: 2141 E-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFE-QNLSEKLSEQELQFRRLS 528
E D +N + +L+R A T+ R +V+E+ + + LS+ + E + R L
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2255
Query: 529 QEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 569
DN + +++ + + +VA +EA + QL
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296
Score = 60.8 bits (146), Expect = 4e-09
Identities = 118/586 (20%), Positives = 225/586 (38%), Gaps = 80/586 (13%)
Query: 111 ISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAA---GDTLSVPAPAVQPEE 167
+ ++ E+ ++++ +L++ + + E AQ + A S Q E
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1594
Query: 168 SLKTDHPEIGEGKPTPA--LSEEASSSSIRERPPEEV----------------AARLAQQ 209
SL+ +H + + + ++A + RE E+ A +AQQ
Sbjct: 1595 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 210 EKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK 269
+ Q + E + E R+ QA+ + E+A ++
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------ELAEQE 1693
Query: 270 KSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKPHITA 326
Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752
Query: 327 AEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKG 386
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1753 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL------ 1806
Query: 387 MSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKR 443
++++ A + L+ +D A A R + + + E K +AL++++ E +R
Sbjct: 1807 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENER 1865
Query: 444 AFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQE 502
A +A + R E QA Q + IEE + ++L RQ D LR +V+E
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925
Query: 503 Q--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------YARLR 547
+ LK+ FE+ + K +E EL+ R+ D ++ A R R
Sbjct: 1926 EILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1984
Query: 548 GIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAVEAIK 600
E+ VQ AEEEA + + L VE LK ++ + + L A EA +
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2044
Query: 601 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 646
E A + L + + E+++ + + ARR A
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Score = 56.6 bits (135), Expect = 8e-08
Identities = 87/400 (21%), Positives = 165/400 (41%), Gaps = 78/400 (19%)
Query: 175 EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 234
++ E E + +++R EEV R +Q K S+ + L+ LRQ++
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEA 1431
Query: 235 TLQAIAAQNAAVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 290
+QA A Q A + + +++ ++ +E Q EG L+ R +E
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEE 1484
Query: 291 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQ 349
A +A+EE E+++ +++ +++ V+L + VK + +AA+
Sbjct: 1485 AEAQKRQAQEEAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAR 1529
Query: 350 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAH 409
+ + + EL +QA + +R + EV + + A + + +L S A
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFA 1586
Query: 410 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 469
+ QL R L E+ H+ +A +++ E R++ QAE +R E
Sbjct: 1587 EKTAQLERSLQEE------HVAVAQLREEAER---------------RAQQQAEAERARE 1625
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQ 529
E +E R QL+ A LR+Q +E+ + + L++ E + ++
Sbjct: 1626 EAERELE---RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEA 1669
Query: 530 EQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 569
E+ A R + EQAV+ +AE+E K QL
Sbjct: 1670 ER---------EARRRGKAEEQAVRQRELAEQELEKQRQL 1700
Score = 47.0 bits (110), Expect = 7e-05
Identities = 118/580 (20%), Positives = 229/580 (39%), Gaps = 79/580 (13%)
Query: 109 LKISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEES 168
L++ E +E Q ++ QK + + A++ + A L++P P+ P
Sbjct: 1007 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG---VARLSAEAEKVLALPEPS--PAAP 1061
Query: 169 LKTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDAL 228
E+ GK L + S S+I + ++ + + E+V + + + L++A
Sbjct: 1062 TLRSELELTLGK----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQLKEA- 1115
Query: 229 RQTASVTLQAIAAQNAAVQAVNAHSNILKAAMD--NSEIAGEKKSAQ------------- 273
Q TL + A A+++ + A + + D E+ G ++ +
Sbjct: 1116 -QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1174
Query: 274 --WRTVEGALKERRKAVDEAADALLKAKEEL-----------EKMKSVIENAKKK-EVAG 319
WR L ER +AV D + E+L + + + +++A+++ E
Sbjct: 1175 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234
Query: 320 AKP--HITAAEGKLHN---MIVDLDNVVKKVQAAQSEAK----VVSQYHELVVQARDDFK 370
A P A +L ++ +++ +KV+ Q AK + Y +V +K
Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT----YK 1290
Query: 371 RELDSIT-----PEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKAT 425
+L+ + P+V G + + + + +L +L + + I + R + E++
Sbjct: 1291 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1350
Query: 426 EKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ--- 482
+Q A E+++L E A ALE R +A K + R+A E + R Q
Sbjct: 1351 AEQQ--RAEERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 483 -LRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDI 539
R +AA + ++ + Q+L+ E + K + E + R +E++ L +
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 540 NTAYARLRGIEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAV 596
+ G E +Q+ A AEE + Q E L+ ++ S + L S V
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1521
Query: 597 EA-IKANCSDNEFTQAL-TAAIPPESLTRGVYSEETLRAR 634
+A +A QAL + E R + E RAR
Sbjct: 1522 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Score = 41.6 bits (96), Expect = 0.003
Identities = 77/357 (21%), Positives = 149/357 (41%), Gaps = 51/357 (14%)
Query: 178 EGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTL 236
E + ++EEA+ S+ + AARL Q +++ + +LA K L++ ++ T
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 237 QAIAAQNAAVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAAD 293
A+ Q A + D ++A E+ RT+E ER++ ++ +A+
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAE 2381
Query: 294 ALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQS 350
A E L+ + + A+ + A+ AE KLH + V VQ +
Sbjct: 2382 A-----ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 351 EAKVVSQYHELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDL 392
+ + E + +A + +RE + + E +L + + S L
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 393 ADKLSTDDLNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAV 449
++K S I +++QL ++ A+Q E+Q ++Q++E++R V
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLV 2549
Query: 450 AKALEHHRSEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 504
A E R + +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2604
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 63.5 bits (153), Expect = 7e-10
Identities = 112/543 (20%), Positives = 203/543 (37%), Gaps = 63/543 (11%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPE 175
E+ + +Q S L + +G+ A+ A EA + A + V+ E LK E
Sbjct: 2032 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2091
Query: 176 IGEGKP-----TPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQ 230
+ + L +EA + R E+ A R Q++ ++E K E LRQ
Sbjct: 2092 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR---QKQAADAEMEKHKKFAEQTLRQ 2148
Query: 231 TASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 290
A V Q + ++ + N+L + + + + Q R V+E
Sbjct: 2149 KAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-----------RSQVEE 2196
Query: 291 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQS 350
++ EEL K+K+ IE + + + D DN + +Q
Sbjct: 2197 ELFSVRVQMEELSKLKARIEAENRALI-----------------LRDKDNTQRFLQEEAE 2239
Query: 351 EAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHAH 409
+ K V++ + A + R L + E L + ++ L +K+ + + L A A
Sbjct: 2240 KMKQVAEEAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2298
Query: 410 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 469
+ Q +ELA+++A Q + +Q EE + F ++AE+ R++E
Sbjct: 2299 --LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQLE 2345
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQFR 525
+A ++R +A A + R Q +E+ + + +L+ QE +Q
Sbjct: 2346 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTL 2402
Query: 526 RLSQEQVDNFTLDINTAYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSMK 581
+ ++Q D+ + A A L ++ +Q A + EE + Q L E
Sbjct: 2403 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2462
Query: 582 TSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKL 641
S + + +E KA + A E R E R R A +
Sbjct: 2463 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2522
Query: 642 ARR 644
ARR
Sbjct: 2523 ARR 2525
Score = 61.6 bits (148), Expect = 3e-09
Identities = 114/521 (21%), Positives = 204/521 (39%), Gaps = 90/521 (17%)
Query: 110 KISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESL 169
++ +++E K +Q A + ++ A A A+ ++A G+ + A E +L
Sbjct: 1773 RLRALAEEAKRQRQLAEEDAARQ-----RAEAERVLAEKLAAIGEATRLKTEA---EIAL 1824
Query: 170 KTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAA--------RLAQQEKQEQVKIESLA 221
K E L A + + R EE AA RLAQ K ++E
Sbjct: 1825 KEKEAE------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1878
Query: 222 KSLEDALRQTASVTLQAIAAQNAAVQAV---------------NAHSNILKAAMDNSEIA 266
+ED LRQ V + +A + + +A NA + E A
Sbjct: 1879 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1938
Query: 267 GEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAK-------- 313
+++ A + R E +++ A +EAA A EE+E++K+ +E A+
Sbjct: 1939 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 1998
Query: 314 --------------KKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYH 359
K+ A K H A + K + L + + EA+ +
Sbjct: 1999 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2058
Query: 360 ELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL--STDDLNSLIAHAHRRIDQLNR 417
E +AR +RE +V + A++L S ++ A A ++L +
Sbjct: 2059 EEAEEARVQAEREAAQSRRQV----------EEAERLKQSAEEQAQARAQAQAAAEKLRK 2108
Query: 418 ELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----ALEHHRSEIQAEQD----RKIE 469
E AEQ+A + E+ L +K+A D+ + K A + R + Q EQ+ R
Sbjct: 2109 E-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2163
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFE-QNLSEKLSEQELQFRRLS 528
E D +N + +L+R A T+ R +V+E+ + + LS+ + E + R L
Sbjct: 2164 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2223
Query: 529 QEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 569
DN + +++ + + +VA +EA + QL
Sbjct: 2224 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2264
Score = 60.8 bits (146), Expect = 4e-09
Identities = 118/586 (20%), Positives = 225/586 (38%), Gaps = 80/586 (13%)
Query: 111 ISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAA---GDTLSVPAPAVQPEE 167
+ ++ E+ ++++ +L++ + + E AQ + A S Q E
Sbjct: 1503 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1562
Query: 168 SLKTDHPEIGEGKPTPA--LSEEASSSSIRERPPEEV----------------AARLAQQ 209
SL+ +H + + + ++A + RE E+ A +AQQ
Sbjct: 1563 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1622
Query: 210 EKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK 269
+ Q + E + E R+ QA+ + E+A ++
Sbjct: 1623 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------ELAEQE 1661
Query: 270 KSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKPHITA 326
Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1662 LEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1720
Query: 327 AEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKG 386
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1721 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL------ 1774
Query: 387 MSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKR 443
++++ A + L+ +D A A R + + + E K +AL++++ E +R
Sbjct: 1775 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENER 1833
Query: 444 AFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQE 502
A +A + R E QA Q + IEE + ++L RQ D LR +V+E
Sbjct: 1834 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1893
Query: 503 Q--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------YARLR 547
+ LK+ FE+ + K +E EL+ R+ D ++ A R R
Sbjct: 1894 EILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1952
Query: 548 GIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAVEAIK 600
E+ VQ AEEEA + + L VE LK ++ + + L A EA +
Sbjct: 1953 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2012
Query: 601 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 646
E A + L + + E+++ + + ARR A
Sbjct: 2013 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2058
Score = 56.6 bits (135), Expect = 8e-08
Identities = 87/400 (21%), Positives = 165/400 (41%), Gaps = 78/400 (19%)
Query: 175 EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 234
++ E E + +++R EEV R +Q K S+ + L+ LRQ++
Sbjct: 1342 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEA 1399
Query: 235 TLQAIAAQNAAVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 290
+QA A Q A + + +++ ++ +E Q EG L+ R +E
Sbjct: 1400 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEE 1452
Query: 291 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQ 349
A +A+EE E+++ +++ +++ V+L + VK + +AA+
Sbjct: 1453 AEAQKRQAQEEAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAR 1497
Query: 350 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAH 409
+ + + EL +QA + +R + EV + + A + + +L S A
Sbjct: 1498 EKQRALQALEELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFA 1554
Query: 410 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 469
+ QL R L E+ H+ +A +++ E R++ QAE +R E
Sbjct: 1555 EKTAQLERSLQEE------HVAVAQLREEAER---------------RAQQQAEAERARE 1593
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQ 529
E +E R QL+ A LR+Q +E+ + + L++ E + ++
Sbjct: 1594 EAERELE---RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEA 1637
Query: 530 EQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 569
E+ A R + EQAV+ +AE+E K QL
Sbjct: 1638 ER---------EARRRGKAEEQAVRQRELAEQELEKQRQL 1668
Score = 47.0 bits (110), Expect = 7e-05
Identities = 118/580 (20%), Positives = 229/580 (39%), Gaps = 79/580 (13%)
Query: 109 LKISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEES 168
L++ E +E Q ++ QK + + A++ + A L++P P+ P
Sbjct: 975 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG---VARLSAEAEKVLALPEPS--PAAP 1029
Query: 169 LKTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDAL 228
E+ GK L + S S+I + ++ + + E+V + + + L++A
Sbjct: 1030 TLRSELELTLGK----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQLKEA- 1083
Query: 229 RQTASVTLQAIAAQNAAVQAVNAHSNILKAAMD--NSEIAGEKKSAQ------------- 273
Q TL + A A+++ + A + + D E+ G ++ +
Sbjct: 1084 -QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1142
Query: 274 --WRTVEGALKERRKAVDEAADALLKAKEEL-----------EKMKSVIENAKKK-EVAG 319
WR L ER +AV D + E+L + + + +++A+++ E
Sbjct: 1143 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1202
Query: 320 AKP--HITAAEGKLHN---MIVDLDNVVKKVQAAQSEAK----VVSQYHELVVQARDDFK 370
A P A +L ++ +++ +KV+ Q AK + Y +V +K
Sbjct: 1203 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT----YK 1258
Query: 371 RELDSIT-----PEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKAT 425
+L+ + P+V G + + + + +L +L + + I + R + E++
Sbjct: 1259 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1318
Query: 426 EKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ--- 482
+Q A E+++L E A ALE R +A K + R+A E + R Q
Sbjct: 1319 AEQQ--RAEERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1369
Query: 483 -LRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDI 539
R +AA + ++ + Q+L+ E + K + E + R +E++ L +
Sbjct: 1370 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1429
Query: 540 NTAYARLRGIEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAV 596
+ G E +Q+ A AEE + Q E L+ ++ S + L S V
Sbjct: 1430 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1489
Query: 597 EA-IKANCSDNEFTQAL-TAAIPPESLTRGVYSEETLRAR 634
+A +A QAL + E R + E RAR
Sbjct: 1490 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1529
Score = 41.6 bits (96), Expect = 0.003
Identities = 77/357 (21%), Positives = 149/357 (41%), Gaps = 51/357 (14%)
Query: 178 EGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTL 236
E + ++EEA+ S+ + AARL Q +++ + +LA K L++ ++ T
Sbjct: 2237 EAEKMKQVAEEAARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292
Query: 237 QAIAAQNAAVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAAD 293
A+ Q A + D ++A E+ RT+E ER++ ++ +A+
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAE 2349
Query: 294 ALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQS 350
A E L+ + + A+ + A+ AE KLH + V VQ +
Sbjct: 2350 A-----ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2404
Query: 351 EAKVVSQYHELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDL 392
+ + E + +A + +RE + + E +L + + S L
Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2464
Query: 393 ADKLSTDDLNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAV 449
++K S I +++QL ++ A+Q E+Q ++Q++E++R V
Sbjct: 2465 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLV 2517
Query: 450 AKALEHHRSEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 504
A E R + +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2518 ASMEEARRRQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2572
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 63.5 bits (153), Expect = 7e-10
Identities = 112/543 (20%), Positives = 203/543 (37%), Gaps = 63/543 (11%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPE 175
E+ + +Q S L + +G+ A+ A EA + A + V+ E LK E
Sbjct: 2201 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2260
Query: 176 IGEGKP-----TPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQ 230
+ + L +EA + R E+ A R Q++ ++E K E LRQ
Sbjct: 2261 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR---QKQAADAEMEKHKKFAEQTLRQ 2317
Query: 231 TASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 290
A V Q + ++ + N+L + + + + Q R V+E
Sbjct: 2318 KAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-----------RSQVEE 2365
Query: 291 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQS 350
++ EEL K+K+ IE + + + D DN + +Q
Sbjct: 2366 ELFSVRVQMEELSKLKARIEAENRALI-----------------LRDKDNTQRFLQEEAE 2408
Query: 351 EAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHAH 409
+ K V++ + A + R L + E L + ++ L +K+ + + L A A
Sbjct: 2409 KMKQVAEEAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2467
Query: 410 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 469
+ Q +ELA+++A Q + +Q EE + F ++AE+ R++E
Sbjct: 2468 --LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQLE 2514
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQFR 525
+A ++R +A A + R Q +E+ + + +L+ QE +Q
Sbjct: 2515 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTL 2571
Query: 526 RLSQEQVDNFTLDINTAYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSMK 581
+ ++Q D+ + A A L ++ +Q A + EE + Q L E
Sbjct: 2572 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2631
Query: 582 TSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKL 641
S + + +E KA + A E R E R R A +
Sbjct: 2632 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2691
Query: 642 ARR 644
ARR
Sbjct: 2692 ARR 2694
Score = 61.6 bits (148), Expect = 3e-09
Identities = 114/521 (21%), Positives = 204/521 (39%), Gaps = 90/521 (17%)
Query: 110 KISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESL 169
++ +++E K +Q A + ++ A A A+ ++A G+ + A E +L
Sbjct: 1942 RLRALAEEAKRQRQLAEEDAARQ-----RAEAERVLAEKLAAIGEATRLKTEA---EIAL 1993
Query: 170 KTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAA--------RLAQQEKQEQVKIESLA 221
K E L A + + R EE AA RLAQ K ++E
Sbjct: 1994 KEKEAE------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 2047
Query: 222 KSLEDALRQTASVTLQAIAAQNAAVQAV---------------NAHSNILKAAMDNSEIA 266
+ED LRQ V + +A + + +A NA + E A
Sbjct: 2048 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 2107
Query: 267 GEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAK-------- 313
+++ A + R E +++ A +EAA A EE+E++K+ +E A+
Sbjct: 2108 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2167
Query: 314 --------------KKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYH 359
K+ A K H A + K + L + + EA+ +
Sbjct: 2168 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2227
Query: 360 ELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL--STDDLNSLIAHAHRRIDQLNR 417
E +AR +RE +V + A++L S ++ A A ++L +
Sbjct: 2228 EEAEEARVQAEREAAQSRRQV----------EEAERLKQSAEEQAQARAQAQAAAEKLRK 2277
Query: 418 ELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----ALEHHRSEIQAEQD----RKIE 469
E AEQ+A + E+ L +K+A D+ + K A + R + Q EQ+ R
Sbjct: 2278 E-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2332
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFE-QNLSEKLSEQELQFRRLS 528
E D +N + +L+R A T+ R +V+E+ + + LS+ + E + R L
Sbjct: 2333 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2392
Query: 529 QEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 569
DN + +++ + + +VA +EA + QL
Sbjct: 2393 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2433
Score = 60.8 bits (146), Expect = 4e-09
Identities = 118/586 (20%), Positives = 225/586 (38%), Gaps = 80/586 (13%)
Query: 111 ISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAA---GDTLSVPAPAVQPEE 167
+ ++ E+ ++++ +L++ + + E AQ + A S Q E
Sbjct: 1672 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1731
Query: 168 SLKTDHPEIGEGKPTPA--LSEEASSSSIRERPPEEV----------------AARLAQQ 209
SL+ +H + + + ++A + RE E+ A +AQQ
Sbjct: 1732 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1791
Query: 210 EKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK 269
+ Q + E + E R+ QA+ + E+A ++
Sbjct: 1792 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------ELAEQE 1830
Query: 270 KSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKPHITA 326
Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1831 LEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1889
Query: 327 AEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKG 386
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1890 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL------ 1943
Query: 387 MSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKR 443
++++ A + L+ +D A A R + + + E K +AL++++ E +R
Sbjct: 1944 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENER 2002
Query: 444 AFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQE 502
A +A + R E QA Q + IEE + ++L RQ D LR +V+E
Sbjct: 2003 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 2062
Query: 503 Q--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------YARLR 547
+ LK+ FE+ + K +E EL+ R+ D ++ A R R
Sbjct: 2063 EILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 2121
Query: 548 GIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAVEAIK 600
E+ VQ AEEEA + + L VE LK ++ + + L A EA +
Sbjct: 2122 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2181
Query: 601 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 646
E A + L + + E+++ + + ARR A
Sbjct: 2182 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2227
Score = 56.6 bits (135), Expect = 8e-08
Identities = 87/400 (21%), Positives = 165/400 (41%), Gaps = 78/400 (19%)
Query: 175 EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 234
++ E E + +++R EEV R +Q K S+ + L+ LRQ++
Sbjct: 1511 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEA 1568
Query: 235 TLQAIAAQNAAVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 290
+QA A Q A + + +++ ++ +E Q EG L+ R +E
Sbjct: 1569 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEE 1621
Query: 291 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQ 349
A +A+EE E+++ +++ +++ V+L + VK + +AA+
Sbjct: 1622 AEAQKRQAQEEAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAR 1666
Query: 350 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAH 409
+ + + EL +QA + +R + EV + + A + + +L S A
Sbjct: 1667 EKQRALQALEELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFA 1723
Query: 410 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 469
+ QL R L E+ H+ +A +++ E R++ QAE +R E
Sbjct: 1724 EKTAQLERSLQEE------HVAVAQLREEAER---------------RAQQQAEAERARE 1762
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQ 529
E +E R QL+ A LR+Q +E+ + + L++ E + ++
Sbjct: 1763 EAERELE---RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEA 1806
Query: 530 EQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 569
E+ A R + EQAV+ +AE+E K QL
Sbjct: 1807 ER---------EARRRGKAEEQAVRQRELAEQELEKQRQL 1837
Score = 47.0 bits (110), Expect = 7e-05
Identities = 118/580 (20%), Positives = 229/580 (39%), Gaps = 79/580 (13%)
Query: 109 LKISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEES 168
L++ E +E Q ++ QK + + A++ + A L++P P+ P
Sbjct: 1144 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG---VARLSAEAEKVLALPEPS--PAAP 1198
Query: 169 LKTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDAL 228
E+ GK L + S S+I + ++ + + E+V + + + L++A
Sbjct: 1199 TLRSELELTLGK----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQLKEA- 1252
Query: 229 RQTASVTLQAIAAQNAAVQAVNAHSNILKAAMD--NSEIAGEKKSAQ------------- 273
Q TL + A A+++ + A + + D E+ G ++ +
Sbjct: 1253 -QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1311
Query: 274 --WRTVEGALKERRKAVDEAADALLKAKEEL-----------EKMKSVIENAKKK-EVAG 319
WR L ER +AV D + E+L + + + +++A+++ E
Sbjct: 1312 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1371
Query: 320 AKP--HITAAEGKLHN---MIVDLDNVVKKVQAAQSEAK----VVSQYHELVVQARDDFK 370
A P A +L ++ +++ +KV+ Q AK + Y +V +K
Sbjct: 1372 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT----YK 1427
Query: 371 RELDSIT-----PEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKAT 425
+L+ + P+V G + + + + +L +L + + I + R + E++
Sbjct: 1428 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1487
Query: 426 EKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ--- 482
+Q A E+++L E A ALE R +A K + R+A E + R Q
Sbjct: 1488 AEQQ--RAEERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1538
Query: 483 -LRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDI 539
R +AA + ++ + Q+L+ E + K + E + R +E++ L +
Sbjct: 1539 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1598
Query: 540 NTAYARLRGIEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAV 596
+ G E +Q+ A AEE + Q E L+ ++ S + L S V
Sbjct: 1599 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1658
Query: 597 EA-IKANCSDNEFTQAL-TAAIPPESLTRGVYSEETLRAR 634
+A +A QAL + E R + E RAR
Sbjct: 1659 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1698
Score = 41.6 bits (96), Expect = 0.003
Identities = 77/357 (21%), Positives = 149/357 (41%), Gaps = 51/357 (14%)
Query: 178 EGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTL 236
E + ++EEA+ S+ + AARL Q +++ + +LA K L++ ++ T
Sbjct: 2406 EAEKMKQVAEEAARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461
Query: 237 QAIAAQNAAVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAAD 293
A+ Q A + D ++A E+ RT+E ER++ ++ +A+
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAE 2518
Query: 294 ALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQS 350
A E L+ + + A+ + A+ AE KLH + V VQ +
Sbjct: 2519 A-----ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2573
Query: 351 EAKVVSQYHELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDL 392
+ + E + +A + +RE + + E +L + + S L
Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2633
Query: 393 ADKLSTDDLNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAV 449
++K S I +++QL ++ A+Q E+Q ++Q++E++R V
Sbjct: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLV 2686
Query: 450 AKALEHHRSEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 504
A E R + +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2687 ASMEEARRRQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2741
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 63.5 bits (153), Expect = 7e-10
Identities = 112/543 (20%), Positives = 203/543 (37%), Gaps = 63/543 (11%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPE 175
E+ + +Q S L + +G+ A+ A EA + A + V+ E LK E
Sbjct: 2042 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2101
Query: 176 IGEGKP-----TPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQ 230
+ + L +EA + R E+ A R Q++ ++E K E LRQ
Sbjct: 2102 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR---QKQAADAEMEKHKKFAEQTLRQ 2158
Query: 231 TASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 290
A V Q + ++ + N+L + + + + Q R V+E
Sbjct: 2159 KAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-----------RSQVEE 2206
Query: 291 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQS 350
++ EEL K+K+ IE + + + D DN + +Q
Sbjct: 2207 ELFSVRVQMEELSKLKARIEAENRALI-----------------LRDKDNTQRFLQEEAE 2249
Query: 351 EAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHAH 409
+ K V++ + A + R L + E L + ++ L +K+ + + L A A
Sbjct: 2250 KMKQVAEEAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2308
Query: 410 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 469
+ Q +ELA+++A Q + +Q EE + F ++AE+ R++E
Sbjct: 2309 --LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQLE 2355
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQFR 525
+A ++R +A A + R Q +E+ + + +L+ QE +Q
Sbjct: 2356 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTL 2412
Query: 526 RLSQEQVDNFTLDINTAYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSMK 581
+ ++Q D+ + A A L ++ +Q A + EE + Q L E
Sbjct: 2413 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2472
Query: 582 TSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKL 641
S + + +E KA + A E R E R R A +
Sbjct: 2473 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2532
Query: 642 ARR 644
ARR
Sbjct: 2533 ARR 2535
Score = 61.6 bits (148), Expect = 3e-09
Identities = 114/521 (21%), Positives = 204/521 (39%), Gaps = 90/521 (17%)
Query: 110 KISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESL 169
++ +++E K +Q A + ++ A A A+ ++A G+ + A E +L
Sbjct: 1783 RLRALAEEAKRQRQLAEEDAARQ-----RAEAERVLAEKLAAIGEATRLKTEA---EIAL 1834
Query: 170 KTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAA--------RLAQQEKQEQVKIESLA 221
K E L A + + R EE AA RLAQ K ++E
Sbjct: 1835 KEKEAE------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1888
Query: 222 KSLEDALRQTASVTLQAIAAQNAAVQAV---------------NAHSNILKAAMDNSEIA 266
+ED LRQ V + +A + + +A NA + E A
Sbjct: 1889 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1948
Query: 267 GEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAK-------- 313
+++ A + R E +++ A +EAA A EE+E++K+ +E A+
Sbjct: 1949 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2008
Query: 314 --------------KKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYH 359
K+ A K H A + K + L + + EA+ +
Sbjct: 2009 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2068
Query: 360 ELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL--STDDLNSLIAHAHRRIDQLNR 417
E +AR +RE +V + A++L S ++ A A ++L +
Sbjct: 2069 EEAEEARVQAEREAAQSRRQV----------EEAERLKQSAEEQAQARAQAQAAAEKLRK 2118
Query: 418 ELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----ALEHHRSEIQAEQD----RKIE 469
E AEQ+A + E+ L +K+A D+ + K A + R + Q EQ+ R
Sbjct: 2119 E-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2173
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFE-QNLSEKLSEQELQFRRLS 528
E D +N + +L+R A T+ R +V+E+ + + LS+ + E + R L
Sbjct: 2174 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2233
Query: 529 QEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 569
DN + +++ + + +VA +EA + QL
Sbjct: 2234 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2274
Score = 60.8 bits (146), Expect = 4e-09
Identities = 118/586 (20%), Positives = 225/586 (38%), Gaps = 80/586 (13%)
Query: 111 ISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAA---GDTLSVPAPAVQPEE 167
+ ++ E+ ++++ +L++ + + E AQ + A S Q E
Sbjct: 1513 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1572
Query: 168 SLKTDHPEIGEGKPTPA--LSEEASSSSIRERPPEEV----------------AARLAQQ 209
SL+ +H + + + ++A + RE E+ A +AQQ
Sbjct: 1573 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1632
Query: 210 EKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK 269
+ Q + E + E R+ QA+ + E+A ++
Sbjct: 1633 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------ELAEQE 1671
Query: 270 KSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKPHITA 326
Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1672 LEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1730
Query: 327 AEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKG 386
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1731 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL------ 1784
Query: 387 MSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKR 443
++++ A + L+ +D A A R + + + E K +AL++++ E +R
Sbjct: 1785 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENER 1843
Query: 444 AFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQE 502
A +A + R E QA Q + IEE + ++L RQ D LR +V+E
Sbjct: 1844 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1903
Query: 503 Q--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------YARLR 547
+ LK+ FE+ + K +E EL+ R+ D ++ A R R
Sbjct: 1904 EILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1962
Query: 548 GIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAVEAIK 600
E+ VQ AEEEA + + L VE LK ++ + + L A EA +
Sbjct: 1963 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2022
Query: 601 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 646
E A + L + + E+++ + + ARR A
Sbjct: 2023 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2068
Score = 56.6 bits (135), Expect = 8e-08
Identities = 87/400 (21%), Positives = 165/400 (41%), Gaps = 78/400 (19%)
Query: 175 EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 234
++ E E + +++R EEV R +Q K S+ + L+ LRQ++
Sbjct: 1352 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEA 1409
Query: 235 TLQAIAAQNAAVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 290
+QA A Q A + + +++ ++ +E Q EG L+ R +E
Sbjct: 1410 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEE 1462
Query: 291 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQ 349
A +A+EE E+++ +++ +++ V+L + VK + +AA+
Sbjct: 1463 AEAQKRQAQEEAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAR 1507
Query: 350 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAH 409
+ + + EL +QA + +R + EV + + A + + +L S A
Sbjct: 1508 EKQRALQALEELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFA 1564
Query: 410 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 469
+ QL R L E+ H+ +A +++ E R++ QAE +R E
Sbjct: 1565 EKTAQLERSLQEE------HVAVAQLREEAER---------------RAQQQAEAERARE 1603
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQ 529
E +E R QL+ A LR+Q +E+ + + L++ E + ++
Sbjct: 1604 EAERELE---RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEA 1647
Query: 530 EQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 569
E+ A R + EQAV+ +AE+E K QL
Sbjct: 1648 ER---------EARRRGKAEEQAVRQRELAEQELEKQRQL 1678
Score = 47.0 bits (110), Expect = 7e-05
Identities = 118/580 (20%), Positives = 229/580 (39%), Gaps = 79/580 (13%)
Query: 109 LKISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEES 168
L++ E +E Q ++ QK + + A++ + A L++P P+ P
Sbjct: 985 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG---VARLSAEAEKVLALPEPS--PAAP 1039
Query: 169 LKTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDAL 228
E+ GK L + S S+I + ++ + + E+V + + + L++A
Sbjct: 1040 TLRSELELTLGK----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQLKEA- 1093
Query: 229 RQTASVTLQAIAAQNAAVQAVNAHSNILKAAMD--NSEIAGEKKSAQ------------- 273
Q TL + A A+++ + A + + D E+ G ++ +
Sbjct: 1094 -QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1152
Query: 274 --WRTVEGALKERRKAVDEAADALLKAKEEL-----------EKMKSVIENAKKK-EVAG 319
WR L ER +AV D + E+L + + + +++A+++ E
Sbjct: 1153 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1212
Query: 320 AKP--HITAAEGKLHN---MIVDLDNVVKKVQAAQSEAK----VVSQYHELVVQARDDFK 370
A P A +L ++ +++ +KV+ Q AK + Y +V +K
Sbjct: 1213 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT----YK 1268
Query: 371 RELDSIT-----PEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKAT 425
+L+ + P+V G + + + + +L +L + + I + R + E++
Sbjct: 1269 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1328
Query: 426 EKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ--- 482
+Q A E+++L E A ALE R +A K + R+A E + R Q
Sbjct: 1329 AEQQ--RAEERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1379
Query: 483 -LRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDI 539
R +AA + ++ + Q+L+ E + K + E + R +E++ L +
Sbjct: 1380 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1439
Query: 540 NTAYARLRGIEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAV 596
+ G E +Q+ A AEE + Q E L+ ++ S + L S V
Sbjct: 1440 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1499
Query: 597 EA-IKANCSDNEFTQAL-TAAIPPESLTRGVYSEETLRAR 634
+A +A QAL + E R + E RAR
Sbjct: 1500 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1539
Score = 41.6 bits (96), Expect = 0.003
Identities = 77/357 (21%), Positives = 149/357 (41%), Gaps = 51/357 (14%)
Query: 178 EGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTL 236
E + ++EEA+ S+ + AARL Q +++ + +LA K L++ ++ T
Sbjct: 2247 EAEKMKQVAEEAARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302
Query: 237 QAIAAQNAAVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAAD 293
A+ Q A + D ++A E+ RT+E ER++ ++ +A+
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAE 2359
Query: 294 ALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQS 350
A E L+ + + A+ + A+ AE KLH + V VQ +
Sbjct: 2360 A-----ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2414
Query: 351 EAKVVSQYHELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDL 392
+ + E + +A + +RE + + E +L + + S L
Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474
Query: 393 ADKLSTDDLNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAV 449
++K S I +++QL ++ A+Q E+Q ++Q++E++R V
Sbjct: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLV 2527
Query: 450 AKALEHHRSEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 504
A E R + +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2528 ASMEEARRRQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2582
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 63.5 bits (153), Expect = 7e-10
Identities = 112/543 (20%), Positives = 203/543 (37%), Gaps = 63/543 (11%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPE 175
E+ + +Q S L + +G+ A+ A EA + A + V+ E LK E
Sbjct: 2050 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2109
Query: 176 IGEGKP-----TPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQ 230
+ + L +EA + R E+ A R Q++ ++E K E LRQ
Sbjct: 2110 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR---QKQAADAEMEKHKKFAEQTLRQ 2166
Query: 231 TASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 290
A V Q + ++ + N+L + + + + Q R V+E
Sbjct: 2167 KAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-----------RSQVEE 2214
Query: 291 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQS 350
++ EEL K+K+ IE + + + D DN + +Q
Sbjct: 2215 ELFSVRVQMEELSKLKARIEAENRALI-----------------LRDKDNTQRFLQEEAE 2257
Query: 351 EAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHAH 409
+ K V++ + A + R L + E L + ++ L +K+ + + L A A
Sbjct: 2258 KMKQVAEEAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2316
Query: 410 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 469
+ Q +ELA+++A Q + +Q EE + F ++AE+ R++E
Sbjct: 2317 --LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQLE 2363
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQFR 525
+A ++R +A A + R Q +E+ + + +L+ QE +Q
Sbjct: 2364 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTL 2420
Query: 526 RLSQEQVDNFTLDINTAYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSMK 581
+ ++Q D+ + A A L ++ +Q A + EE + Q L E
Sbjct: 2421 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2480
Query: 582 TSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKL 641
S + + +E KA + A E R E R R A +
Sbjct: 2481 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2540
Query: 642 ARR 644
ARR
Sbjct: 2541 ARR 2543
Score = 61.6 bits (148), Expect = 3e-09
Identities = 114/521 (21%), Positives = 204/521 (39%), Gaps = 90/521 (17%)
Query: 110 KISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESL 169
++ +++E K +Q A + ++ A A A+ ++A G+ + A E +L
Sbjct: 1791 RLRALAEEAKRQRQLAEEDAARQ-----RAEAERVLAEKLAAIGEATRLKTEA---EIAL 1842
Query: 170 KTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAA--------RLAQQEKQEQVKIESLA 221
K E L A + + R EE AA RLAQ K ++E
Sbjct: 1843 KEKEAE------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1896
Query: 222 KSLEDALRQTASVTLQAIAAQNAAVQAV---------------NAHSNILKAAMDNSEIA 266
+ED LRQ V + +A + + +A NA + E A
Sbjct: 1897 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1956
Query: 267 GEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAK-------- 313
+++ A + R E +++ A +EAA A EE+E++K+ +E A+
Sbjct: 1957 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2016
Query: 314 --------------KKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYH 359
K+ A K H A + K + L + + EA+ +
Sbjct: 2017 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2076
Query: 360 ELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL--STDDLNSLIAHAHRRIDQLNR 417
E +AR +RE +V + A++L S ++ A A ++L +
Sbjct: 2077 EEAEEARVQAEREAAQSRRQV----------EEAERLKQSAEEQAQARAQAQAAAEKLRK 2126
Query: 418 ELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----ALEHHRSEIQAEQD----RKIE 469
E AEQ+A + E+ L +K+A D+ + K A + R + Q EQ+ R
Sbjct: 2127 E-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2181
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFE-QNLSEKLSEQELQFRRLS 528
E D +N + +L+R A T+ R +V+E+ + + LS+ + E + R L
Sbjct: 2182 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2241
Query: 529 QEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 569
DN + +++ + + +VA +EA + QL
Sbjct: 2242 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2282
Score = 60.8 bits (146), Expect = 4e-09
Identities = 118/586 (20%), Positives = 225/586 (38%), Gaps = 80/586 (13%)
Query: 111 ISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAA---GDTLSVPAPAVQPEE 167
+ ++ E+ ++++ +L++ + + E AQ + A S Q E
Sbjct: 1521 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1580
Query: 168 SLKTDHPEIGEGKPTPA--LSEEASSSSIRERPPEEV----------------AARLAQQ 209
SL+ +H + + + ++A + RE E+ A +AQQ
Sbjct: 1581 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1640
Query: 210 EKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK 269
+ Q + E + E R+ QA+ + E+A ++
Sbjct: 1641 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------ELAEQE 1679
Query: 270 KSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKPHITA 326
Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1680 LEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1738
Query: 327 AEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKG 386
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1739 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL------ 1792
Query: 387 MSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKR 443
++++ A + L+ +D A A R + + + E K +AL++++ E +R
Sbjct: 1793 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENER 1851
Query: 444 AFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQE 502
A +A + R E QA Q + IEE + ++L RQ D LR +V+E
Sbjct: 1852 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1911
Query: 503 Q--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------YARLR 547
+ LK+ FE+ + K +E EL+ R+ D ++ A R R
Sbjct: 1912 EILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1970
Query: 548 GIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAVEAIK 600
E+ VQ AEEEA + + L VE LK ++ + + L A EA +
Sbjct: 1971 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2030
Query: 601 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 646
E A + L + + E+++ + + ARR A
Sbjct: 2031 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2076
Score = 56.6 bits (135), Expect = 8e-08
Identities = 87/400 (21%), Positives = 165/400 (41%), Gaps = 78/400 (19%)
Query: 175 EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 234
++ E E + +++R EEV R +Q K S+ + L+ LRQ++
Sbjct: 1360 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEA 1417
Query: 235 TLQAIAAQNAAVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 290
+QA A Q A + + +++ ++ +E Q EG L+ R +E
Sbjct: 1418 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEE 1470
Query: 291 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQ 349
A +A+EE E+++ +++ +++ V+L + VK + +AA+
Sbjct: 1471 AEAQKRQAQEEAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAR 1515
Query: 350 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAH 409
+ + + EL +QA + +R + EV + + A + + +L S A
Sbjct: 1516 EKQRALQALEELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFA 1572
Query: 410 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 469
+ QL R L E+ H+ +A +++ E R++ QAE +R E
Sbjct: 1573 EKTAQLERSLQEE------HVAVAQLREEAER---------------RAQQQAEAERARE 1611
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQ 529
E +E R QL+ A LR+Q +E+ + + L++ E + ++
Sbjct: 1612 EAERELE---RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEA 1655
Query: 530 EQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 569
E+ A R + EQAV+ +AE+E K QL
Sbjct: 1656 ER---------EARRRGKAEEQAVRQRELAEQELEKQRQL 1686
Score = 47.0 bits (110), Expect = 7e-05
Identities = 118/580 (20%), Positives = 229/580 (39%), Gaps = 79/580 (13%)
Query: 109 LKISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEES 168
L++ E +E Q ++ QK + + A++ + A L++P P+ P
Sbjct: 993 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG---VARLSAEAEKVLALPEPS--PAAP 1047
Query: 169 LKTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDAL 228
E+ GK L + S S+I + ++ + + E+V + + + L++A
Sbjct: 1048 TLRSELELTLGK----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQLKEA- 1101
Query: 229 RQTASVTLQAIAAQNAAVQAVNAHSNILKAAMD--NSEIAGEKKSAQ------------- 273
Q TL + A A+++ + A + + D E+ G ++ +
Sbjct: 1102 -QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1160
Query: 274 --WRTVEGALKERRKAVDEAADALLKAKEEL-----------EKMKSVIENAKKK-EVAG 319
WR L ER +AV D + E+L + + + +++A+++ E
Sbjct: 1161 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1220
Query: 320 AKP--HITAAEGKLHN---MIVDLDNVVKKVQAAQSEAK----VVSQYHELVVQARDDFK 370
A P A +L ++ +++ +KV+ Q AK + Y +V +K
Sbjct: 1221 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT----YK 1276
Query: 371 RELDSIT-----PEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKAT 425
+L+ + P+V G + + + + +L +L + + I + R + E++
Sbjct: 1277 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1336
Query: 426 EKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ--- 482
+Q A E+++L E A ALE R +A K + R+A E + R Q
Sbjct: 1337 AEQQ--RAEERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1387
Query: 483 -LRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDI 539
R +AA + ++ + Q+L+ E + K + E + R +E++ L +
Sbjct: 1388 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1447
Query: 540 NTAYARLRGIEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAV 596
+ G E +Q+ A AEE + Q E L+ ++ S + L S V
Sbjct: 1448 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1507
Query: 597 EA-IKANCSDNEFTQAL-TAAIPPESLTRGVYSEETLRAR 634
+A +A QAL + E R + E RAR
Sbjct: 1508 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1547
Score = 41.6 bits (96), Expect = 0.003
Identities = 77/357 (21%), Positives = 149/357 (41%), Gaps = 51/357 (14%)
Query: 178 EGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTL 236
E + ++EEA+ S+ + AARL Q +++ + +LA K L++ ++ T
Sbjct: 2255 EAEKMKQVAEEAARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310
Query: 237 QAIAAQNAAVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAAD 293
A+ Q A + D ++A E+ RT+E ER++ ++ +A+
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAE 2367
Query: 294 ALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQS 350
A E L+ + + A+ + A+ AE KLH + V VQ +
Sbjct: 2368 A-----ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2422
Query: 351 EAKVVSQYHELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDL 392
+ + E + +A + +RE + + E +L + + S L
Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2482
Query: 393 ADKLSTDDLNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAV 449
++K S I +++QL ++ A+Q E+Q ++Q++E++R V
Sbjct: 2483 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLV 2535
Query: 450 AKALEHHRSEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 504
A E R + +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2536 ASMEEARRRQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2590
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 63.5 bits (153), Expect = 7e-10
Identities = 112/543 (20%), Positives = 203/543 (37%), Gaps = 63/543 (11%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPE 175
E+ + +Q S L + +G+ A+ A EA + A + V+ E LK E
Sbjct: 2091 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2150
Query: 176 IGEGKP-----TPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQ 230
+ + L +EA + R E+ A R Q++ ++E K E LRQ
Sbjct: 2151 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR---QKQAADAEMEKHKKFAEQTLRQ 2207
Query: 231 TASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 290
A V Q + ++ + N+L + + + + Q R V+E
Sbjct: 2208 KAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-----------RSQVEE 2255
Query: 291 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQS 350
++ EEL K+K+ IE + + + D DN + +Q
Sbjct: 2256 ELFSVRVQMEELSKLKARIEAENRALI-----------------LRDKDNTQRFLQEEAE 2298
Query: 351 EAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHAH 409
+ K V++ + A + R L + E L + ++ L +K+ + + L A A
Sbjct: 2299 KMKQVAEEAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2357
Query: 410 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 469
+ Q +ELA+++A Q + +Q EE + F ++AE+ R++E
Sbjct: 2358 --LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQLE 2404
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQFR 525
+A ++R +A A + R Q +E+ + + +L+ QE +Q
Sbjct: 2405 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTL 2461
Query: 526 RLSQEQVDNFTLDINTAYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSMK 581
+ ++Q D+ + A A L ++ +Q A + EE + Q L E
Sbjct: 2462 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2521
Query: 582 TSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKL 641
S + + +E KA + A E R E R R A +
Sbjct: 2522 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2581
Query: 642 ARR 644
ARR
Sbjct: 2582 ARR 2584
Score = 61.6 bits (148), Expect = 3e-09
Identities = 114/521 (21%), Positives = 204/521 (39%), Gaps = 90/521 (17%)
Query: 110 KISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESL 169
++ +++E K +Q A + ++ A A A+ ++A G+ + A E +L
Sbjct: 1832 RLRALAEEAKRQRQLAEEDAARQ-----RAEAERVLAEKLAAIGEATRLKTEA---EIAL 1883
Query: 170 KTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAA--------RLAQQEKQEQVKIESLA 221
K E L A + + R EE AA RLAQ K ++E
Sbjct: 1884 KEKEAE------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1937
Query: 222 KSLEDALRQTASVTLQAIAAQNAAVQAV---------------NAHSNILKAAMDNSEIA 266
+ED LRQ V + +A + + +A NA + E A
Sbjct: 1938 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1997
Query: 267 GEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAK-------- 313
+++ A + R E +++ A +EAA A EE+E++K+ +E A+
Sbjct: 1998 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2057
Query: 314 --------------KKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYH 359
K+ A K H A + K + L + + EA+ +
Sbjct: 2058 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2117
Query: 360 ELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL--STDDLNSLIAHAHRRIDQLNR 417
E +AR +RE +V + A++L S ++ A A ++L +
Sbjct: 2118 EEAEEARVQAEREAAQSRRQV----------EEAERLKQSAEEQAQARAQAQAAAEKLRK 2167
Query: 418 ELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----ALEHHRSEIQAEQD----RKIE 469
E AEQ+A + E+ L +K+A D+ + K A + R + Q EQ+ R
Sbjct: 2168 E-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2222
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFE-QNLSEKLSEQELQFRRLS 528
E D +N + +L+R A T+ R +V+E+ + + LS+ + E + R L
Sbjct: 2223 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2282
Query: 529 QEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 569
DN + +++ + + +VA +EA + QL
Sbjct: 2283 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2323
Score = 60.8 bits (146), Expect = 4e-09
Identities = 118/586 (20%), Positives = 225/586 (38%), Gaps = 80/586 (13%)
Query: 111 ISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAA---GDTLSVPAPAVQPEE 167
+ ++ E+ ++++ +L++ + + E AQ + A S Q E
Sbjct: 1562 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1621
Query: 168 SLKTDHPEIGEGKPTPA--LSEEASSSSIRERPPEEV----------------AARLAQQ 209
SL+ +H + + + ++A + RE E+ A +AQQ
Sbjct: 1622 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1681
Query: 210 EKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK 269
+ Q + E + E R+ QA+ + E+A ++
Sbjct: 1682 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------ELAEQE 1720
Query: 270 KSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKPHITA 326
Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1721 LEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1779
Query: 327 AEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKG 386
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1780 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL------ 1833
Query: 387 MSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKR 443
++++ A + L+ +D A A R + + + E K +AL++++ E +R
Sbjct: 1834 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENER 1892
Query: 444 AFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQE 502
A +A + R E QA Q + IEE + ++L RQ D LR +V+E
Sbjct: 1893 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1952
Query: 503 Q--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------YARLR 547
+ LK+ FE+ + K +E EL+ R+ D ++ A R R
Sbjct: 1953 EILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 2011
Query: 548 GIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAVEAIK 600
E+ VQ AEEEA + + L VE LK ++ + + L A EA +
Sbjct: 2012 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2071
Query: 601 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 646
E A + L + + E+++ + + ARR A
Sbjct: 2072 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2117
Score = 56.6 bits (135), Expect = 8e-08
Identities = 87/400 (21%), Positives = 165/400 (41%), Gaps = 78/400 (19%)
Query: 175 EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 234
++ E E + +++R EEV R +Q K S+ + L+ LRQ++
Sbjct: 1401 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEA 1458
Query: 235 TLQAIAAQNAAVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 290
+QA A Q A + + +++ ++ +E Q EG L+ R +E
Sbjct: 1459 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEE 1511
Query: 291 AADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQ 349
A +A+EE E+++ +++ +++ V+L + VK + +AA+
Sbjct: 1512 AEAQKRQAQEEAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAR 1556
Query: 350 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAH 409
+ + + EL +QA + +R + EV + + A + + +L S A
Sbjct: 1557 EKQRALQALEELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFA 1613
Query: 410 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIE 469
+ QL R L E+ H+ +A +++ E R++ QAE +R E
Sbjct: 1614 EKTAQLERSLQEE------HVAVAQLREEAER---------------RAQQQAEAERARE 1652
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQ 529
E +E R QL+ A LR+Q +E+ + + L++ E + ++
Sbjct: 1653 EAERELE---RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEA 1696
Query: 530 EQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 569
E+ A R + EQAV+ +AE+E K QL
Sbjct: 1697 ER---------EARRRGKAEEQAVRQRELAEQELEKQRQL 1727
Score = 47.0 bits (110), Expect = 7e-05
Identities = 118/580 (20%), Positives = 229/580 (39%), Gaps = 79/580 (13%)
Query: 109 LKISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEES 168
L++ E +E Q ++ QK + + A++ + A L++P P+ P
Sbjct: 1034 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG---VARLSAEAEKVLALPEPS--PAAP 1088
Query: 169 LKTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDAL 228
E+ GK L + S S+I + ++ + + E+V + + + L++A
Sbjct: 1089 TLRSELELTLGK----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQLKEA- 1142
Query: 229 RQTASVTLQAIAAQNAAVQAVNAHSNILKAAMD--NSEIAGEKKSAQ------------- 273
Q TL + A A+++ + A + + D E+ G ++ +
Sbjct: 1143 -QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1201
Query: 274 --WRTVEGALKERRKAVDEAADALLKAKEEL-----------EKMKSVIENAKKK-EVAG 319
WR L ER +AV D + E+L + + + +++A+++ E
Sbjct: 1202 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1261
Query: 320 AKP--HITAAEGKLHN---MIVDLDNVVKKVQAAQSEAK----VVSQYHELVVQARDDFK 370
A P A +L ++ +++ +KV+ Q AK + Y +V +K
Sbjct: 1262 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT----YK 1317
Query: 371 RELDSIT-----PEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKAT 425
+L+ + P+V G + + + + +L +L + + I + R + E++
Sbjct: 1318 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1377
Query: 426 EKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ--- 482
+Q A E+++L E A ALE R +A K + R+A E + R Q
Sbjct: 1378 AEQQ--RAEERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1428
Query: 483 -LRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDI 539
R +AA + ++ + Q+L+ E + K + E + R +E++ L +
Sbjct: 1429 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1488
Query: 540 NTAYARLRGIEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAV 596
+ G E +Q+ A AEE + Q E L+ ++ S + L S V
Sbjct: 1489 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1548
Query: 597 EA-IKANCSDNEFTQAL-TAAIPPESLTRGVYSEETLRAR 634
+A +A QAL + E R + E RAR
Sbjct: 1549 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1588
Score = 41.6 bits (96), Expect = 0.003
Identities = 77/357 (21%), Positives = 149/357 (41%), Gaps = 51/357 (14%)
Query: 178 EGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTL 236
E + ++EEA+ S+ + AARL Q +++ + +LA K L++ ++ T
Sbjct: 2296 EAEKMKQVAEEAARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351
Query: 237 QAIAAQNAAVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAAD 293
A+ Q A + D ++A E+ RT+E ER++ ++ +A+
Sbjct: 2352 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAE 2408
Query: 294 ALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQS 350
A E L+ + + A+ + A+ AE KLH + V VQ +
Sbjct: 2409 A-----ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2463
Query: 351 EAKVVSQYHELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDL 392
+ + E + +A + +RE + + E +L + + S L
Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2523
Query: 393 ADKLSTDDLNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAV 449
++K S I +++QL ++ A+Q E+Q ++Q++E++R V
Sbjct: 2524 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLV 2576
Query: 450 AKALEHHRSEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 504
A E R + +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2577 ASMEEARRRQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2631
>gi|110611218 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 61.6 bits (148), Expect = 3e-09
Identities = 135/623 (21%), Positives = 234/623 (37%), Gaps = 79/623 (12%)
Query: 85 LFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEV--MKESKQPASQLQKQKGDTPASATAP 142
L E V PA P P + P+ ++ V+ V M + K +S K+K + + P
Sbjct: 96 LREPVRAPAVAVAPTPVQP----PIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEP 151
Query: 143 TEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALSEEASSSSIRERPPEEV 202
++ + S T P+E TD + E A +++ S S +++ P +
Sbjct: 152 AVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGS--KKKGPPDA 209
Query: 203 AARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDN 262
L K + S+ + +A R L I ++ A + H KA
Sbjct: 210 DGPLYLPYKTLVSTVGSMVFNEGEAQR------LIEILSEKAGIIQDTWH----KATQKG 259
Query: 263 SEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKP 322
+A K+ L+E+ K + + AK +L ++ KE+A K
Sbjct: 260 DPVAILKRQ---------LEEKEKLLATEQEDAAVAKSKLRELN--------KEMAAEKA 302
Query: 323 HITAAEGKLHNMIVDLDNVVKKVQAAQ--SEAKVVSQYHELVVQARDDFKRELDSITPEV 380
A E K+ +V + + VQA S + V + +L + R + +L++ P
Sbjct: 303 KAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIR-TLQEQLEN-GPNT 360
Query: 381 LPGWKGMSVSDLADKLS------TDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLAL 434
S L D L+ N+ +A + + ++++EL E+ +Q
Sbjct: 361 QLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQD----- 415
Query: 435 EKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHL 494
E++R A A A E ++QA R+ EE +E+ +L ++H
Sbjct: 416 -----EQQRKALEAKAAAFEKQVLQLQASH-RESEEALQKRLDEVSRELCHTQSSHASLR 469
Query: 495 RDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQE------QVDNFTLDINTAYARLRG 548
D + QEQ+ + L KL E + R +E Q+ + + R+R
Sbjct: 470 ADAEKAQEQQQQM---AELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRS 526
Query: 549 IE---QAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSD 605
IE +A Q+ + +A +A + + S E I L AVE K +D
Sbjct: 527 IEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNND 586
Query: 606 --NEFTQALTAAIPPE--------SLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSL 655
+ +A+ A E SLT+ E A Q + +A++ E
Sbjct: 587 LREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEA-QTMEALLALLPELSVLA 645
Query: 656 YQYFLSYLQSLLLFPPQQLKPPP 678
Q + +LQ L P LK PP
Sbjct: 646 QQNYTEWLQDLKEKGPTLLKHPP 668
Score = 45.1 bits (105), Expect = 2e-04
Identities = 98/470 (20%), Positives = 182/470 (38%), Gaps = 58/470 (12%)
Query: 160 APAVQPEESLKTDHPEIGEGKPTPALSEEASSSSIRERP----PEEVAARLAQQEKQEQV 215
A A Q +E KT H ++ + K + ++ + E+P P+ A +E V
Sbjct: 41 ALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREPV 100
Query: 216 KIESLAKS---LEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSA 272
+ ++A + ++ + T+ A+ + A + K A ++ S
Sbjct: 101 RAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSI 160
Query: 273 QWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLH 332
Q T + A+ E A E + + E K E KK+ K A+G L+
Sbjct: 161 QVLTSKAAILE--TAPKEGRNTDVAQSPEAPKQ----EAPAKKKSGSKKKGPPDADGPLY 214
Query: 333 NMIVDLDNVVKKVQAAQSEA-KVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSD 391
L + V + + EA +++ E +D + + P + + +
Sbjct: 215 LPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAI---LKRQLEE 271
Query: 392 LADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKL----EEKRAFDS 447
L+T+ ++ +A + ++ +LN+E+A +KA K A K++L +E A +
Sbjct: 272 KEKLLATEQEDAAVAKS--KLRELNKEMAAEKA--KAAAGEAKVKKQLVAREQEITAVQA 327
Query: 448 AVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKS 507
+ + H E+Q Q KI +++ +EN TQL R LRD L +++S
Sbjct: 328 RMQASYREHVKEVQQLQG-KIRTLQEQLENGPNTQLAR-LQQENSILRDALNQATSQVES 385
Query: 508 -------EFEQNLSEKLSE---------QELQFRRLSQEQVDNFTLDINTAYARLRGIEQ 551
+ Q LS+ E Q+ Q R+ + + F + A R E+
Sbjct: 386 KQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEE 445
Query: 552 AVQ---------------SHAVAEEEARKAHQLWLSVEALKYSMKTSSAE 586
A+Q SHA +A KA + + L +++S AE
Sbjct: 446 ALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAE 495
>gi|110611220 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 61.6 bits (148), Expect = 3e-09
Identities = 135/623 (21%), Positives = 234/623 (37%), Gaps = 79/623 (12%)
Query: 85 LFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEV--MKESKQPASQLQKQKGDTPASATAP 142
L E V PA P P + P+ ++ V+ V M + K +S K+K + + P
Sbjct: 96 LREPVRAPAVAVAPTPVQP----PIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEP 151
Query: 143 TEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALSEEASSSSIRERPPEEV 202
++ + S T P+E TD + E A +++ S S +++ P +
Sbjct: 152 AVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGS--KKKGPPDA 209
Query: 203 AARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDN 262
L K + S+ + +A R L I ++ A + H KA
Sbjct: 210 DGPLYLPYKTLVSTVGSMVFNEGEAQR------LIEILSEKAGIIQDTWH----KATQKG 259
Query: 263 SEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKP 322
+A K+ L+E+ K + + AK +L ++ KE+A K
Sbjct: 260 DPVAILKRQ---------LEEKEKLLATEQEDAAVAKSKLRELN--------KEMAAEKA 302
Query: 323 HITAAEGKLHNMIVDLDNVVKKVQAAQ--SEAKVVSQYHELVVQARDDFKRELDSITPEV 380
A E K+ +V + + VQA S + V + +L + R + +L++ P
Sbjct: 303 KAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIR-TLQEQLEN-GPNT 360
Query: 381 LPGWKGMSVSDLADKLS------TDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLAL 434
S L D L+ N+ +A + + ++++EL E+ +Q
Sbjct: 361 QLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQD----- 415
Query: 435 EKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHL 494
E++R A A A E ++QA R+ EE +E+ +L ++H
Sbjct: 416 -----EQQRKALEAKAAAFEKQVLQLQASH-RESEEALQKRLDEVSRELCHTQSSHASLR 469
Query: 495 RDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQE------QVDNFTLDINTAYARLRG 548
D + QEQ+ + L KL E + R +E Q+ + + R+R
Sbjct: 470 ADAEKAQEQQQQM---AELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRS 526
Query: 549 IE---QAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSD 605
IE +A Q+ + +A +A + + S E I L AVE K +D
Sbjct: 527 IEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNND 586
Query: 606 --NEFTQALTAAIPPE--------SLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSL 655
+ +A+ A E SLT+ E A Q + +A++ E
Sbjct: 587 LREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEA-QTMEALLALLPELSVLA 645
Query: 656 YQYFLSYLQSLLLFPPQQLKPPP 678
Q + +LQ L P LK PP
Sbjct: 646 QQNYTEWLQDLKEKGPTLLKHPP 668
Score = 45.1 bits (105), Expect = 2e-04
Identities = 98/470 (20%), Positives = 182/470 (38%), Gaps = 58/470 (12%)
Query: 160 APAVQPEESLKTDHPEIGEGKPTPALSEEASSSSIRERP----PEEVAARLAQQEKQEQV 215
A A Q +E KT H ++ + K + ++ + E+P P+ A +E V
Sbjct: 41 ALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREPV 100
Query: 216 KIESLAKS---LEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSA 272
+ ++A + ++ + T+ A+ + A + K A ++ S
Sbjct: 101 RAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSI 160
Query: 273 QWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLH 332
Q T + A+ E A E + + E K E KK+ K A+G L+
Sbjct: 161 QVLTSKAAILE--TAPKEGRNTDVAQSPEAPKQ----EAPAKKKSGSKKKGPPDADGPLY 214
Query: 333 NMIVDLDNVVKKVQAAQSEA-KVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSD 391
L + V + + EA +++ E +D + + P + + +
Sbjct: 215 LPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAI---LKRQLEE 271
Query: 392 LADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKL----EEKRAFDS 447
L+T+ ++ +A + ++ +LN+E+A +KA K A K++L +E A +
Sbjct: 272 KEKLLATEQEDAAVAKS--KLRELNKEMAAEKA--KAAAGEAKVKKQLVAREQEITAVQA 327
Query: 448 AVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKS 507
+ + H E+Q Q KI +++ +EN TQL R LRD L +++S
Sbjct: 328 RMQASYREHVKEVQQLQG-KIRTLQEQLENGPNTQLAR-LQQENSILRDALNQATSQVES 385
Query: 508 -------EFEQNLSEKLSE---------QELQFRRLSQEQVDNFTLDINTAYARLRGIEQ 551
+ Q LS+ E Q+ Q R+ + + F + A R E+
Sbjct: 386 KQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEE 445
Query: 552 AVQ---------------SHAVAEEEARKAHQLWLSVEALKYSMKTSSAE 586
A+Q SHA +A KA + + L +++S AE
Sbjct: 446 ALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAE 495
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 59.3 bits (142), Expect = 1e-08
Identities = 86/412 (20%), Positives = 170/412 (41%), Gaps = 48/412 (11%)
Query: 185 LSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNA 244
L E R EE L ++K+ Q I+ L + LE+ + L+ + + A
Sbjct: 913 LEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTE-A 971
Query: 245 AVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEK 304
++ + IL+ N ++A EKK + R E + +E + +L K K + E
Sbjct: 972 KLKKLEEEQIILED--QNCKLAKEKKLLEDRIAEFTTNLTEE--EEKSKSLAKLKNKHEA 1027
Query: 305 MKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKV---------- 354
M + +E ++E + + KL DL + + ++QA +E K+
Sbjct: 1028 MITDLEERLRREEK-QRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQ 1086
Query: 355 --VSQYHELVVQARDDFK--RELDSITPEVLPGWKGMSVS-DLADKLSTDDLNSLIAHAH 409
+++ E Q K REL+S E+ + S + A+K D L A
Sbjct: 1087 AALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT 1146
Query: 410 RRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEI------QAE 463
D L+ A+Q+ K+ + + K+ LEE+ A + + S+ Q E
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206
Query: 464 QDRKI----EEVRDAMENEM-----RTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQ--- 511
Q +++ E+ + +ENE ++ Q ++H R + Q QEL+ +F +
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266
Query: 512 ---NLSEKLSEQELQFRRL------SQEQVDNFTLDINTAYARLRGIEQAVQ 554
L++K+++ +++ + S + T D + ++L+ ++ +Q
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ 1318
Score = 58.5 bits (140), Expect = 2e-08
Identities = 106/509 (20%), Positives = 208/509 (40%), Gaps = 66/509 (12%)
Query: 185 LSEEASSSS--IRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQ 242
L+EE + S+ ER E AR +++ K SLA++LE+A+ Q A + +
Sbjct: 1450 LAEEKTISAKYAEERDRAEAEAR------EKETKALSLARALEEAMEQKAELERLNKQFR 1503
Query: 243 NAAVQAVNAHSNILKAA--MDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 300
+++ ++ K+ ++ S+ A E++ + +T L+E + DA L+ +
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKT---QLEELEDELQATEDAKLRLEV 1560
Query: 301 ELEKMKSVIE----------NAKKKEVA--------------GAKPHITAAEGKLHNMIV 336
L+ MK+ E KKK++ + AA KL +
Sbjct: 1561 NLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLK 1620
Query: 337 DLDNVVKKVQAAQSEAKVVSQYHELVVQAR------DDFKRELDSITPEVLPGWKGMSVS 390
DL+ + + EA + Q +L Q + DD + + I + K +
Sbjct: 1621 DLEAHIDSANKNRDEA--IKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSM 1678
Query: 391 DLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVA 450
+ A+ + + + A R+ Q ELA++ A LALE+++ E R + +
Sbjct: 1679 E-AEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARI--AQLE 1735
Query: 451 KALEHHRSEIQAEQDR------KIEEVRDAMENE-MRTQLRRQAAAHTDHLRDVLRVQEQ 503
+ LE + + DR +I+++ + E Q A + L+V+ Q
Sbjct: 1736 EELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQ 1795
Query: 504 ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAV-AEEE 562
E++ + ++ E + +L +EQ+DN T + A ++R E+ ++ + ++E
Sbjct: 1796 EMEGTVKSKYKASITALEAKIAQL-EEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE 1854
Query: 563 ARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQAL-TAAIPPESL 621
R A Q + +K + + EA +AN S + + L A +++
Sbjct: 1855 RRNAEQYKDQADKASTRLKQLKRQLEE----AEEEAQRANASRRKLQRELEDATETADAM 1910
Query: 622 TRGVYSEETLRAR----FYAVQKLARRVA 646
R V S + R F +++AR+ A
Sbjct: 1911 NREVSSLKNKLRRGDLPFVVPRRMARKGA 1939
Score = 51.6 bits (122), Expect = 3e-06
Identities = 82/389 (21%), Positives = 176/389 (45%), Gaps = 47/389 (12%)
Query: 185 LSEEASSSSIRERPPEEVAA--RLAQQEK-QEQVKIESLAKSLEDALRQTASVTLQAI-- 239
+++E +RE+ ++AA RL + E Q Q+ E L L++ L+ + +A
Sbjct: 848 MAKEEELVKVREK---QLAAENRLTEMETLQSQLMAEKL--QLQEQLQAETELCAEAEEL 902
Query: 240 -AAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKA 298
A A Q + + L+A ++ E + A+ + ++ ++E + ++E A K
Sbjct: 903 RARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL 962
Query: 299 KEELEKMKSVIENAKKKEVAGAKPHITAAEGK--LHNMIVDLD-NVVKKVQAAQSEAKVV 355
+ E ++ ++ +++++ + A+ K L + I + N+ ++ + ++S AK+
Sbjct: 963 QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLK 1022
Query: 356 SQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTD--DLNSLIAHAHRRID 413
+++ ++ + +RE + + KL D DL+ IA +I
Sbjct: 1023 NKHEAMITDLEERLRREEK----------QRQELEKTRRKLEGDSTDLSDQIAELQAQIA 1072
Query: 414 QLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRD 473
+L +LA+++ E+ LA ++EE+ A + K + E + +I E+++
Sbjct: 1073 ELKMQLAKKE--EELQAALA----RVEEEAAQKNMALKKIR--------ELESQISELQE 1118
Query: 474 AMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVD 533
+E+E + R +A L + L + LK+E E L ++QEL+ +R + +
Sbjct: 1119 DLESERAS--RNKAEKQKRDLGEEL----EALKTELEDTLDSTAAQQELRSKREQEVNIL 1172
Query: 534 NFTLDINTAYARLRGIEQAVQSHAVAEEE 562
TL+ A I++ Q H+ A EE
Sbjct: 1173 KKTLE-EEAKTHEAQIQEMRQKHSQAVEE 1200
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 58.5 bits (140), Expect = 2e-08
Identities = 86/430 (20%), Positives = 186/430 (43%), Gaps = 53/430 (12%)
Query: 184 ALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQN 243
+L E S +E E A++ +Q + + K++ + L++ + + +
Sbjct: 1518 SLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEM 1577
Query: 244 AAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELE 303
+ HS +++ + E A + + + +E L+E E +L+ K ELE
Sbjct: 1578 EMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEY----EDKQKVLREKRELE 1633
Query: 304 -KMKSVIENAKKKEVAGAK---PHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYH 359
K+ ++ + +++ K + + L + + LD++ + + A++ +Q
Sbjct: 1634 GKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLE 1693
Query: 360 E------LVVQARDDFKRELDSITPEVLPGWKGMSV------------SDLADKLSTD-- 399
E V+AR + E++ + ++ K + +++ ++L D
Sbjct: 1694 ESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQE 1753
Query: 400 DLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHR-- 457
D+N L+ + Q +R+LA+ + Q EKQ+L+EK + + LE
Sbjct: 1754 DMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVD 1813
Query: 458 SEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKL 517
+ + Q+ KI E+ +E E RTQ++R + L L+ ++L E +Q ++ +
Sbjct: 1814 KSLVSRQEAKIRELETRLEFE-RTQVKR-----LESLASRLKENMEKLTEERDQRIAAEN 1867
Query: 518 SEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEA-RKAHQLWLSVEAL 576
E+E Q +RL ++ LR ++ + A E EA RK H+L + +E+L
Sbjct: 1868 REKE-QNKRLQRQ---------------LRDTKEEMGELARKEAEASRKKHELEMDLESL 1911
Query: 577 KYSMKTSSAE 586
+ + ++ A+
Sbjct: 1912 EAANQSLQAD 1921
Score = 47.8 bits (112), Expect = 4e-05
Identities = 77/368 (20%), Positives = 147/368 (39%), Gaps = 59/368 (16%)
Query: 188 EASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQ 247
E +S ER E A++L E E+++ E K L+ A+ Q ++
Sbjct: 1293 ELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQ--------TQYDALKKQMEVME 1344
Query: 248 AVNAHSNILKAAMDNSEIAGEKKSAQWR-TVEGALKE----RRKAVDEAADAL---LKAK 299
+ +++AA N E+ + +WR E A++E +++ E D L + K
Sbjct: 1345 MEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNK 1404
Query: 300 EELEK-----------MKSVIENAKKK------EVAGAKPHITAAEGKLHNMIVDLDNVV 342
+LE+ + ++ KKK E+ K H+ + + H +L+
Sbjct: 1405 RQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNH----ELEKKQ 1460
Query: 343 KKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLN 402
++ + S+A +Q +L R+ +RE D + E L +L D++
Sbjct: 1461 RRFDSELSQAHEEAQREKL---QREKLQREKDMLLAEAF---------SLKQQLEEKDMD 1508
Query: 403 SLIAHAHRRIDQLNRELAEQKATE-KQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQ 461
IA +++ L EL + + E K +LA K++L + A + L+ IQ
Sbjct: 1509 --IAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQ 1566
Query: 462 AEQDRKI------EEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSE 515
+ K+ E +R EM ++ A + L+ E +L+ E+E
Sbjct: 1567 MLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEAR-QSCQKKLKQMEVQLEEEYEDKQKV 1625
Query: 516 KLSEQELQ 523
++EL+
Sbjct: 1626 LREKRELE 1633
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 58.5 bits (140), Expect = 2e-08
Identities = 86/430 (20%), Positives = 186/430 (43%), Gaps = 53/430 (12%)
Query: 184 ALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQN 243
+L E S +E E A++ +Q + + K++ + L++ + + +
Sbjct: 1518 SLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEM 1577
Query: 244 AAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELE 303
+ HS +++ + E A + + + +E L+E E +L+ K ELE
Sbjct: 1578 EMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEY----EDKQKVLREKRELE 1633
Query: 304 -KMKSVIENAKKKEVAGAK---PHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYH 359
K+ ++ + +++ K + + L + + LD++ + + A++ +Q
Sbjct: 1634 GKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLE 1693
Query: 360 E------LVVQARDDFKRELDSITPEVLPGWKGMSV------------SDLADKLSTD-- 399
E V+AR + E++ + ++ K + +++ ++L D
Sbjct: 1694 ESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQE 1753
Query: 400 DLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHR-- 457
D+N L+ + Q +R+LA+ + Q EKQ+L+EK + + LE
Sbjct: 1754 DMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVD 1813
Query: 458 SEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKL 517
+ + Q+ KI E+ +E E RTQ++R + L L+ ++L E +Q ++ +
Sbjct: 1814 KSLVSRQEAKIRELETRLEFE-RTQVKR-----LESLASRLKENMEKLTEERDQRIAAEN 1867
Query: 518 SEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEA-RKAHQLWLSVEAL 576
E+E Q +RL ++ LR ++ + A E EA RK H+L + +E+L
Sbjct: 1868 REKE-QNKRLQRQ---------------LRDTKEEMGELARKEAEASRKKHELEMDLESL 1911
Query: 577 KYSMKTSSAE 586
+ + ++ A+
Sbjct: 1912 EAANQSLQAD 1921
Score = 47.8 bits (112), Expect = 4e-05
Identities = 77/368 (20%), Positives = 147/368 (39%), Gaps = 59/368 (16%)
Query: 188 EASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQ 247
E +S ER E A++L E E+++ E K L+ A+ Q ++
Sbjct: 1293 ELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQ--------TQYDALKKQMEVME 1344
Query: 248 AVNAHSNILKAAMDNSEIAGEKKSAQWR-TVEGALKE----RRKAVDEAADAL---LKAK 299
+ +++AA N E+ + +WR E A++E +++ E D L + K
Sbjct: 1345 MEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNK 1404
Query: 300 EELEK-----------MKSVIENAKKK------EVAGAKPHITAAEGKLHNMIVDLDNVV 342
+LE+ + ++ KKK E+ K H+ + + H +L+
Sbjct: 1405 RQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNH----ELEKKQ 1460
Query: 343 KKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLN 402
++ + S+A +Q +L R+ +RE D + E L +L D++
Sbjct: 1461 RRFDSELSQAHEEAQREKL---QREKLQREKDMLLAEAF---------SLKQQLEEKDMD 1508
Query: 403 SLIAHAHRRIDQLNRELAEQKATE-KQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQ 461
IA +++ L EL + + E K +LA K++L + A + L+ IQ
Sbjct: 1509 --IAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQ 1566
Query: 462 AEQDRKI------EEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSE 515
+ K+ E +R EM ++ A + L+ E +L+ E+E
Sbjct: 1567 MLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEAR-QSCQKKLKQMEVQLEEEYEDKQKV 1625
Query: 516 KLSEQELQ 523
++EL+
Sbjct: 1626 LREKRELE 1633
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 58.5 bits (140), Expect = 2e-08
Identities = 91/428 (21%), Positives = 188/428 (43%), Gaps = 41/428 (9%)
Query: 154 DTLSVPAPAV-QPEESLKTDHPEIGEGKPTPALSEEASSSSIRERPP-----EEVAARLA 207
DT+S A+ Q E +K E+ + + + + ++E+ + L
Sbjct: 1968 DTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELL 2027
Query: 208 QQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAG 267
+ + Q K++SL K + AL T IA N + + S L+A + S+
Sbjct: 2028 KDKTHLQEKLQSLEKDSQ-ALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDY-- 2084
Query: 268 EKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAA 327
EK + + +E AL E+ E A L +EE+ +++ IE + + A K + A
Sbjct: 2085 EKLNVS-KALEAALVEK----GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIA 2139
Query: 328 EGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGM 387
E KL + D++ KV+ + E ++ + ELV+ ++ K E++++ ++ + +
Sbjct: 2140 E-KLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSL 2198
Query: 388 SVSDL---ADKLSTDDLNSLIAHAHRRIDQLNRELAEQKA--TEKQHITLALEKQK---- 438
V +L + ++L I ++ +L++ L+ K+ EK+ + ++++
Sbjct: 2199 KVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAV 2258
Query: 439 ---LEEKRAFDSAVAKALEHHRSEIQAEQ--DRKIEEVRDAMENEMRTQLRRQAAAHTDH 493
+ + + AVA EQ D IEE E+++R + + A
Sbjct: 2259 EMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEE-----EHQLRNSIEKLRARLEAD 2313
Query: 494 LRDVLRVQEQELKSEFEQNLSE---KLSEQELQFRRLSQE----QVDNFTLDINTAYARL 546
+ L V +Q +SE +L + + E+EL+ R +QE + +N ++ T A++
Sbjct: 2314 EKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKI 2373
Query: 547 RGIEQAVQ 554
G+ Q+++
Sbjct: 2374 EGMTQSLR 2381
Score = 47.4 bits (111), Expect = 5e-05
Identities = 98/495 (19%), Positives = 216/495 (43%), Gaps = 48/495 (9%)
Query: 119 KESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGE 178
KE K ++ Q+ + + E ++++ D L V A + S K E
Sbjct: 306 KEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDEL-VRTTAQYDQASTKYTALEQKL 364
Query: 179 GKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQA 238
K T LS + ++ E+ ++ ++EK+ Q ++ +S + ++ + ++A
Sbjct: 365 KKLTEDLSCQRQNAESARCSLEQ---KIKEKEKEFQEELSRQQRSFQTLDQEC--IQMKA 419
Query: 239 IAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKA 298
Q QA N H N+L+A +D K ++ + +E L+E ++ + A A +
Sbjct: 420 RLTQELQ-QAKNMH-NVLQAELD-------KLTSVKQQLENNLEEFKQKLCRAEQAFQAS 470
Query: 299 KEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQS-----EAK 353
+ + +++ +E KK+ K H ++ ++ +L N+ + + +Q+ +AK
Sbjct: 471 QIKENELRRSMEEMKKENNL-LKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAK 529
Query: 354 VVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRID 413
SQ ++ ++ ++ +S+T E L ++V+DL + D L+ I+
Sbjct: 530 NTSQ-ETMLRDLQEKINQQENSLTLEKLK----LAVADLEKQ--RDCSQDLLKKREHHIE 582
Query: 414 QLNRELAEQKATEKQHIT-LALEKQKLEEKR-------AFDSAVAKALEHHRSEIQAEQD 465
QLN +L++ + K ++ L L+K++ EE + + S K L SE + Q
Sbjct: 583 QLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQS 642
Query: 466 R--------KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKL 517
+ K ++++ NE L + +R++ V + + Q L+
Sbjct: 643 KINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYME 702
Query: 518 SEQELQFR-RLSQEQVDNFTLDINTAYARLRGIEQAVQ--SHAVAEEEARKAHQLWLSVE 574
+Q+ +F + Q++++N L + ++ +E +Q S+ + +++ R L E
Sbjct: 703 LQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKD-RCYQDLHAEYE 761
Query: 575 ALKYSMKTSSAETPT 589
+L+ +K+ A T
Sbjct: 762 SLRDLLKSKDASLVT 776
Score = 34.3 bits (77), Expect = 0.44
Identities = 62/356 (17%), Positives = 136/356 (38%), Gaps = 72/356 (20%)
Query: 256 LKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKK 315
L+ +D + +++ Q ++E AL+++++ V+ K E +++ + E+ +K
Sbjct: 23 LEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKT 82
Query: 316 ------EVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDF 369
E+ + + EG+L++ ++ + ++++ +SE + Q + + +
Sbjct: 83 KQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPC 142
Query: 370 KRELDSITPEVLPG--WKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEK 427
T + P + G DL +K N+E+ E+K E
Sbjct: 143 NTPQKIFTTPLTPSQYYSGSKYEDLKEKY-------------------NKEVEERKRLEA 183
Query: 428 QHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQA 487
+ AL+ +K + + + + H++ ++ + N RT +RR
Sbjct: 184 E--VKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDF 241
Query: 488 AAH-------------------------------TDHLRDVLRVQEQELKSEFEQNLSEK 516
+A + HL D L+ Q QEL++ K
Sbjct: 242 SASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRN--------K 293
Query: 517 LSEQELQFRRLSQE---QVDNF-TLDINTAYARLRGIEQAVQSHAVAEEEARKAHQ 568
++E EL+ + +E QV+ F L + A++ IE+ + +E R Q
Sbjct: 294 INELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQ 349
Score = 34.3 bits (77), Expect = 0.44
Identities = 56/330 (16%), Positives = 137/330 (41%), Gaps = 49/330 (14%)
Query: 207 AQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQA--------VNAHSNILKA 258
++Q+ +E +E+ K+++ L Q+ + + + A+N + + +N N L
Sbjct: 495 SEQKAREVCHLEAELKNIKQCLNQSQNFA-EEMKAKNTSQETMLRDLQEKINQQENSL-- 551
Query: 259 AMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKK--KE 316
++ ++A Q + LK+R +++ D L K ++E + + S +E KK +E
Sbjct: 552 TLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEE 611
Query: 317 VAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSI 376
+ K + + + ++ +++ + +Q+ + + + ++ ++ R L+
Sbjct: 612 LKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLE-- 669
Query: 377 TPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEK 436
+ ++L+ I + H +D + E+ QK L
Sbjct: 670 -------------------MDRENLSVEIRNLHNVLDSKSVEVETQK----------LAY 700
Query: 437 QKLEEKRAF-DSAVAKALEHH--RSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDH 493
+L++K F D K +E+ ++ Q +E + NE+ + R H ++
Sbjct: 701 MELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEY 760
Query: 494 --LRDVLRVQEQELKSEFEQNLSEKLSEQE 521
LRD+L+ ++ L + + S +Q+
Sbjct: 761 ESLRDLLKSKDASLVTNEDHQRSLLAFDQQ 790
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 58.5 bits (140), Expect = 2e-08
Identities = 58/250 (23%), Positives = 109/250 (43%), Gaps = 28/250 (11%)
Query: 302 LEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHEL 361
+EK + +EN ++KE A E K L+ V K + + V Q E
Sbjct: 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRR----LEEVKLK---REERLRKVLQARER 587
Query: 362 VVQARDDFKRELDSITPEVLPGWKGMSVSDLAD-----KLSTDDLNSLIAHAHRRIDQLN 416
V Q +++ K++++ ++ + LA+ K + + + A + +
Sbjct: 588 VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR 647
Query: 417 RELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRD--- 473
+Q+ E++H L +K++ E++R +A AK L R + + EQ+R+ +E R+
Sbjct: 648 LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQER 707
Query: 474 ------------AMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE 521
A + R Q R QA LR+Q+++L+ E E+ +K +Q
Sbjct: 708 REQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK-KKKEEQQR 766
Query: 522 LQFRRLSQEQ 531
L R+L +EQ
Sbjct: 767 LAERQLQEEQ 776
Score = 38.5 bits (88), Expect = 0.023
Identities = 32/139 (23%), Positives = 67/139 (48%), Gaps = 13/139 (9%)
Query: 438 KLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDV 497
+++ K +F + LE+ R + +AEQ R R +E + R +L + LR V
Sbjct: 527 RMDPKCSFVEKERQRLENLRRKEEAEQLR-----RQKVEEDKRRRLEEVKLKREERLRKV 581
Query: 498 LRVQE--QELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQS 555
L+ +E +++K E ++ + +K ++ + + + +E++ A ++ + V++
Sbjct: 582 LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKM----EEVEA 637
Query: 556 HAVAEEEARKAHQLWLSVE 574
EEEAR+ WL E
Sbjct: 638 RRKQEEEARRLR--WLQQE 654
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 58.2 bits (139), Expect = 3e-08
Identities = 102/500 (20%), Positives = 210/500 (42%), Gaps = 64/500 (12%)
Query: 102 KSIQSGPLKISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAP 161
K ++ +I+ + E + K ++ +KQK D A + + DTL A
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEA------LKTELEDTLDTTAA 1164
Query: 162 AVQPEESLKTDHP-EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESL 220
++ L+T E+ E K AL EE + A++ ++ +E L
Sbjct: 1165 ----QQELRTKREQEVAELKK--ALEEETKNHE----------AQIQDMRQRHATALEEL 1208
Query: 221 AKSLEDALRQTASV--TLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVE 278
++ LE A R A++ Q + N + + +L+ SE +K AQ + +
Sbjct: 1209 SEQLEQAKRFKANLEKNKQGLETDN---KELACEVKVLQQVKAESEHKRKKLDAQVQELH 1265
Query: 279 GALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDL 338
+ E + E A+ K + EL+ + +++E A+KK + AK + E +L + L
Sbjct: 1266 AKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAK-DAASLESQLQDTQELL 1324
Query: 339 D-------NVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGM---- 387
N+ +++ + E + + E +AR + ++++ ++ ++ K +
Sbjct: 1325 QEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDL 1384
Query: 388 ----SVSDLADKLSTD--DLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQK--- 438
S+ + KL D L+ + D+L + + E +T+ L+ Q+
Sbjct: 1385 GTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEK-TKNRLQQELDDLTVDLDHQRQVA 1443
Query: 439 --LEEK-RAFDSAVAK--------ALEHHRSEIQA-EQDRKIEEVRDAMEN--EMRTQLR 484
LE+K + FD +A+ A E R+E +A E++ K + A+E E + +
Sbjct: 1444 SNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFE 1503
Query: 485 RQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYA 544
RQ + D++ ++ K+ E S++ EQ+++ R E++++ A
Sbjct: 1504 RQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKL 1563
Query: 545 RLRGIEQAVQSHAVAEEEAR 564
RL QA+++ + + R
Sbjct: 1564 RLEVNMQAMKAQFERDLQTR 1583
Score = 57.8 bits (138), Expect = 4e-08
Identities = 97/433 (22%), Positives = 169/433 (39%), Gaps = 73/433 (16%)
Query: 200 EEVAARLAQQEKQE-QVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKA 258
EE ++ Q EK++ Q I+ L + L++ + L+ + A+ + IL
Sbjct: 934 EEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAE---AKIKKMEEEILLL 990
Query: 259 AMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVA 318
NS+ EKK + R E + + + +E A L K + + E M S +E KKE
Sbjct: 991 EDQNSKFIKEKKLMEDRIAECSSQLAEE--EEKAKNLAKIRNKQEVMISDLEERLKKEEK 1048
Query: 319 GAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQ---ARDDFK----- 370
+ + A+ KL DL + + ++QA E K+ E +Q AR D +
Sbjct: 1049 -TRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN 1107
Query: 371 ------RELDSITPEVLPGWKGMSVS-DLADKLSTDDLNSLIAHAHRRIDQLNRELAEQK 423
REL + E+ ++ S + A+K D L A D L+ A+Q+
Sbjct: 1108 NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE 1167
Query: 424 ATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVR----------- 472
K+ +A K+ LEE+ A + + + E ++E+ +
Sbjct: 1168 LRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQ 1227
Query: 473 ----DAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQN------LSEKLSEQEL 522
D E ++ +Q A ++H R L Q QEL ++ + L+EK S+ +
Sbjct: 1228 GLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN 1287
Query: 523 QFRRLS---------------------------QEQVDNFTLDINTAYARLRGIEQ---A 552
+ +S QE + T +R+R +E+ +
Sbjct: 1288 ELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNS 1347
Query: 553 VQSHAVAEEEARK 565
+Q EEEARK
Sbjct: 1348 LQEQQEEEEEARK 1360
Score = 48.9 bits (115), Expect = 2e-05
Identities = 111/572 (19%), Positives = 221/572 (38%), Gaps = 54/572 (9%)
Query: 73 ESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKESKQPASQLQKQK 132
E+ K + K+ + V + + +Q K+S + E + AS+LQ +
Sbjct: 1230 ETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNEL 1289
Query: 133 GDTPASATAPTEAAQI-ISAAGDTLSVPAPAVQPEESLKTD-HPEIGEGKPTPALSEEAS 190
+ +T EA + I A D S+ + +E L+ + ++ L EE +
Sbjct: 1290 DNV---STLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKN 1346
Query: 191 SSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLED-------------ALRQTASVTLQ 237
S ++ EE L +Q Q ++ K ++D L + A Q
Sbjct: 1347 SLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQ 1406
Query: 238 AIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE--AADAL 295
+ + A + N L+ +D+ + + + R V L++++K D+ A +
Sbjct: 1407 RLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQ----RQVASNLEKKQKKFDQLLAEEKS 1462
Query: 296 LKAK--EELEKMKSVIENAKKKEVAGAKPHITAAEGK-------------LHNMIVDLDN 340
+ A+ EE ++ ++ + K ++ A+ A E K + +++ D+
Sbjct: 1463 ISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDD 1522
Query: 341 VVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLP---GWKGMSVSDLADKLS 397
V K V + + + Q E + ++ + EL + L + M D +
Sbjct: 1523 VGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQT 1582
Query: 398 TDDLNSLIAHAHRRIDQLNREL-AEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHH 456
D+ N R + + REL AE + KQ K+K+E A +A
Sbjct: 1583 RDEQNE---EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA 1639
Query: 457 RSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQ--NLS 514
R E+ +Q RK++ + E+ +A A D + + E++LKS + L
Sbjct: 1640 RDEV-IKQLRKLQAQMKDYQRELE-----EARASRDEIFAQSKESEKKLKSLEAEILQLQ 1693
Query: 515 EKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVE 574
E+L+ E R QE+ + N+A + +++ + A + + + ++E
Sbjct: 1694 EELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNME 1753
Query: 575 ALKYSMKTSSAETPTIPLGSAVEAIKANCSDN 606
L + ++ + T+ A E A SDN
Sbjct: 1754 LLNDRFRKTTLQVDTLNAELAAERSAAQKSDN 1785
Score = 48.1 bits (113), Expect = 3e-05
Identities = 105/509 (20%), Positives = 198/509 (38%), Gaps = 117/509 (22%)
Query: 189 ASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQA 248
A SI R EE R + ++++ K SLA++LE+AL Q +
Sbjct: 1458 AEEKSISARYAEE-RDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDL 1516
Query: 249 VNAHSNILKAA--MDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMK 306
+++ ++ K ++ S+ A E++ + RT L++ +A + DA L+ + ++ MK
Sbjct: 1517 MSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATE---DAKLRLEVNMQAMK 1573
Query: 307 SVIE---------NAKKK------------EVAGAKPHITAAEGKLHNMIVDLDNVVKKV 345
+ E N +KK E+ + A M +DL ++ ++
Sbjct: 1574 AQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQI 1633
Query: 346 QAA-QSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSL 404
+AA ++ +V+ Q +L Q +D ++REL+ + S D++
Sbjct: 1634 EAANKARDEVIKQLRKLQAQMKD-YQRELEEA------------------RASRDEI--- 1671
Query: 405 IAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQ--- 461
A+ K +EK+ +L E +L+E+ A + E R E+
Sbjct: 1672 --------------FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEI 1717
Query: 462 ---------------------AEQDRKIEEVRDAME-------------NEMRTQL--RR 485
A+ + ++EE + ME + + +L R
Sbjct: 1718 TNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER 1777
Query: 486 QAAAHTDHLRDVLRVQEQELKSEFEQ-------NLSEKLSEQELQFRRLSQEQVDNFTLD 538
AA +D+ R L Q +ELK++ ++ +S E + +L +EQ++ +
Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQL-EEQLEQEAKE 1836
Query: 539 INTAYARLRGIEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVE 597
A +R E+ ++ E+E R A Q +E MK + + E
Sbjct: 1837 RAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEE----AEEE 1892
Query: 598 AIKANCSDNEFTQALTAAIPP-ESLTRGV 625
A +AN S + + L A E L+R V
Sbjct: 1893 ATRANASRRKLQRELDDATEANEGLSREV 1921
Score = 32.0 bits (71), Expect = 2.2
Identities = 53/252 (21%), Positives = 105/252 (41%), Gaps = 34/252 (13%)
Query: 413 DQLNRELAEQKATEKQHITLALEKQKLEE-KRAFDSAVAKALEHHRSEIQAEQDRK---- 467
+QL E E+ LA +KQ+LEE +S V + E R++I + +K
Sbjct: 894 EQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEE--EEERNQILQNEKKKMQAH 951
Query: 468 IEEVRDAMENEMRTQLRRQAAAHTDHLR------DVLRVQEQELKSEFEQNLSE-KLSEQ 520
I+++ + ++ E + + Q T + ++L +++Q K E+ L E +++E
Sbjct: 952 IQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011
Query: 521 ELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSM 580
Q +E+ N N + +E+ ++ +E KA + K
Sbjct: 1012 SSQLAE-EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKR--------KLDG 1062
Query: 581 KTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRAR--FYAV 638
+T+ + L + ++ +K + E + L A L RG +ETL V
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKE--EELQGA-----LARG--DDETLHKNNALKVV 1113
Query: 639 QKLARRVAMIDE 650
++L ++A + E
Sbjct: 1114 RELQAQIAELQE 1125
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 58.2 bits (139), Expect = 3e-08
Identities = 58/249 (23%), Positives = 108/249 (43%), Gaps = 28/249 (11%)
Query: 303 EKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELV 362
EK + +EN ++KE A E K L+ V K + + V Q E V
Sbjct: 532 EKERQRLENLRRKEEAEQLRRQKVEEDKRRR----LEEVKLK---REERLRKVLQARERV 584
Query: 363 VQARDDFKRELDSITPEVLPGWKGMSVSDLAD-----KLSTDDLNSLIAHAHRRIDQLNR 417
Q +++ K++++ ++ + LA+ K + + + A + +
Sbjct: 585 EQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL 644
Query: 418 ELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRD---- 473
+Q+ E++H L +K++ E++R +A AK L R + + EQ+R+ +E R+
Sbjct: 645 RWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR 704
Query: 474 -----------AMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL 522
A + R Q R QA LR+Q+++L+ E E+ +K +Q L
Sbjct: 705 EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK-KKKEEQQRL 763
Query: 523 QFRRLSQEQ 531
R+L +EQ
Sbjct: 764 AERQLQEEQ 772
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 57.4 bits (137), Expect = 5e-08
Identities = 92/410 (22%), Positives = 178/410 (43%), Gaps = 62/410 (15%)
Query: 186 SEEASSSSI-RERPPEEVAARLAQQEKQE--QVKIESLAKSLEDALRQTASVTLQAIAAQ 242
+E + +SSI RE E+ Q+ E QVK E+L K L+ + A + +A++ Q
Sbjct: 767 AESSKASSITRELQGRELKLTNLQENLSEVSQVK-ETLEKELQILKEKFAEASEEAVSVQ 825
Query: 243 NAAVQAVNA-HSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEE 301
+ + VN H + M +S++ EK +E +E+ DE + L+KAKE+
Sbjct: 826 RSMQETVNKLHQKEEQFNMLSSDL--EKLRENLADMEAKFREK----DEREEQLIKAKEK 879
Query: 302 LEK-----MKSVIENA------------KKKEVAGAKPHITAAEGKLHNMIVDLDNVVKK 344
LE MK +N+ K+++V + +T A + ++++ K
Sbjct: 880 LENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVK 939
Query: 345 VQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLST--DDLN 402
+ +Q EA + ++ K+EL+ +SDL K+ T +
Sbjct: 940 AEQSQQEA----------AKKHEEEKKELE------------RKLSDLEKKMETSHNQCQ 977
Query: 403 SLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQA 462
L A R + + ++ + TL + KL+ R +S + + LE R QA
Sbjct: 978 ELKARYERATSETKTK--HEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK--QA 1033
Query: 463 EQDRKIEEVRDAME-NEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLS--EKLSE 519
++ + + DAM+ E T+ + + A + + + EL + E NL E+L++
Sbjct: 1034 DKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNK 1093
Query: 520 QELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 569
+ + + ++++ F +I T + +++ Q A+ EE + A +L
Sbjct: 1094 SK-ELLTVENQKMEEFRKEIET--LKQAAAQKSQQLSALQEENVKLAEEL 1140
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 57.4 bits (137), Expect = 5e-08
Identities = 92/410 (22%), Positives = 178/410 (43%), Gaps = 62/410 (15%)
Query: 186 SEEASSSSI-RERPPEEVAARLAQQEKQE--QVKIESLAKSLEDALRQTASVTLQAIAAQ 242
+E + +SSI RE E+ Q+ E QVK E+L K L+ + A + +A++ Q
Sbjct: 802 AESSKASSITRELQGRELKLTNLQENLSEVSQVK-ETLEKELQILKEKFAEASEEAVSVQ 860
Query: 243 NAAVQAVNA-HSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEE 301
+ + VN H + M +S++ EK +E +E+ DE + L+KAKE+
Sbjct: 861 RSMQETVNKLHQKEEQFNMLSSDL--EKLRENLADMEAKFREK----DEREEQLIKAKEK 914
Query: 302 LEK-----MKSVIENA------------KKKEVAGAKPHITAAEGKLHNMIVDLDNVVKK 344
LE MK +N+ K+++V + +T A + ++++ K
Sbjct: 915 LENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVK 974
Query: 345 VQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLST--DDLN 402
+ +Q EA + ++ K+EL+ +SDL K+ T +
Sbjct: 975 AEQSQQEA----------AKKHEEEKKELE------------RKLSDLEKKMETSHNQCQ 1012
Query: 403 SLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQA 462
L A R + + ++ + TL + KL+ R +S + + LE R QA
Sbjct: 1013 ELKARYERATSETKTK--HEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK--QA 1068
Query: 463 EQDRKIEEVRDAME-NEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLS--EKLSE 519
++ + + DAM+ E T+ + + A + + + EL + E NL E+L++
Sbjct: 1069 DKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNK 1128
Query: 520 QELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 569
+ + + ++++ F +I T + +++ Q A+ EE + A +L
Sbjct: 1129 SK-ELLTVENQKMEEFRKEIET--LKQAAAQKSQQLSALQEENVKLAEEL 1175
Score = 36.2 bits (82), Expect = 0.12
Identities = 31/124 (25%), Positives = 65/124 (52%), Gaps = 8/124 (6%)
Query: 405 IAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQ 464
+A A + ++ +ELA + QH+ L LE K+++ R A + ++++ E+
Sbjct: 378 VAKATSHVGEIEQELALARDGHDQHV-LELEA-KMDQLRTMVEAADREKVELLNQLE-EE 434
Query: 465 DRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQF 524
RK+E+++ +E E T+ + +H R++E E FE+ ++KL ++EL+
Sbjct: 435 KRKVEDLQFRVEEESITKGDLETQTKLEH----ARIKELEQSLLFEKTKADKL-QRELED 489
Query: 525 RRLS 528
R++
Sbjct: 490 TRVA 493
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 57.0 bits (136), Expect = 6e-08
Identities = 108/526 (20%), Positives = 214/526 (40%), Gaps = 88/526 (16%)
Query: 114 VSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPE----ESL 169
+S ++E + SQL + K A E + + + A A+Q + L
Sbjct: 1288 LSRQLEEKESIVSQLSRSK---QAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLL 1344
Query: 170 KTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALR 229
+ + E EGK + ++S + + + + + E+ E+ K + LA+ L+D+
Sbjct: 1345 REQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK-KKLAQRLQDSEE 1403
Query: 230 QTASV---------TLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRT---- 276
Q +V T Q + + + +N L AA+D + +K A+W+T
Sbjct: 1404 QVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEE 1463
Query: 277 ----VEGALKERR----------KAVDEAADALLKAKEELEKM--------KSVIENAK- 313
+E +LKE R A +EA D L K E + + + + EN K
Sbjct: 1464 SQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKT 1523
Query: 314 -------KKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAK-----VVSQYHEL 361
+K++ K I A + + + + ++Q ++ K +++ E
Sbjct: 1524 IHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEE 1583
Query: 362 VVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSL---IAHAHRRIDQLNRE 418
+ Q + +++R ++++ + + + + K DLN + ++HA+R+ + +
Sbjct: 1584 IEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKH 1643
Query: 419 LAEQKATEKQ---HITLALEKQK-LEEKRAFDSAVAKALEHHRSEI-----QAEQDRKIE 469
L + K H+ AL Q+ L+E+ A A L+ E+ Q E+ RK+
Sbjct: 1644 LRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLA 1703
Query: 470 EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFE------QNLSEK----LSE 519
E ++ +++ R QL H + L +L+SE E +N EK +++
Sbjct: 1704 E-QELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITD 1762
Query: 520 QELQFRRLSQEQVDNFTLDINTAYARL-RGIEQAVQ--SHAVAEEE 562
+ L +EQ D + R+ + +EQ V+ H + E E
Sbjct: 1763 AAMMAEELKKEQ------DTSAHLERMKKNLEQTVKDLQHRLDEAE 1802
Score = 48.9 bits (115), Expect = 2e-05
Identities = 111/546 (20%), Positives = 210/546 (38%), Gaps = 69/546 (12%)
Query: 115 SEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHP 174
+E KE + QK K + S E + + + VQ E D
Sbjct: 844 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE 903
Query: 175 EIGEGKPTPALSEEASSSSIRERPP--EEVAARLAQQEKQEQVKIESLAKSLEDALRQTA 232
E + EA + ER EE+ A L ++++ + + L K ++D A
Sbjct: 904 ERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 963
Query: 233 SVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAA 292
V + A +N S + + +++ EKK+ Q + AL + + A ++
Sbjct: 964 KVEKEKHATENKVKNLTEELSGLDETI---AKLTREKKALQ-EAHQQALDDLQ-AEEDKV 1018
Query: 293 DALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEA 352
++L K K +LE+ +E++ ++E + VDL+ +K++ A
Sbjct: 1019 NSLNKTKSKLEQQVEDLESSLEQE---------------KKLRVDLERNKRKLEGDLKLA 1063
Query: 353 KVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSL-----IAH 407
+ E ++ +D K++LD + K L K+ + L I
Sbjct: 1064 Q------ESILDLEND-KQQLDERLKK-----KDFEYCQLQSKVEDEQTLGLQFQKKIKE 1111
Query: 408 AHRRIDQLNREL----AEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAE 463
RI++L E+ A + TEKQ A E ++L E+ V + +AE
Sbjct: 1112 LQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAE 1171
Query: 464 ---QDRKIEEV---RDAMENEMRTQLRRQAAAHTDHLRDVLRVQE--QELKSEFEQNLSE 515
R +EE +AM +R + A + + ++ RV++ ++ KSEF+ + +
Sbjct: 1172 FLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDD 1231
Query: 516 KLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEA 575
S E + S+ ++ + + RG + +Q +++E +K+ L EA
Sbjct: 1232 LSSSMESVSK--SKANLEKICRTLEDQLSEARGKNEEIQ-RSLSELTTQKSR---LQTEA 1285
Query: 576 LKYSMKTSSAETPTIPLGSAVEAI------------KANCSDNEFTQALTAAIPPESLTR 623
+ S + E+ L + +A + N + N AL ++ L R
Sbjct: 1286 GELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLR 1345
Query: 624 GVYSEE 629
Y EE
Sbjct: 1346 EQYEEE 1351
Score = 46.2 bits (108), Expect = 1e-04
Identities = 91/419 (21%), Positives = 175/419 (41%), Gaps = 58/419 (13%)
Query: 200 EEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQ------AIAAQNAAVQAVNAHS 253
E+ A L +Q + I L KS + + A + L A+ + A + +
Sbjct: 1507 EQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLEL 1566
Query: 254 NILKAAMD------NSEIAGEKKSAQWRTVE---GALKERRKAVDEAADALLKAKEELEK 304
+K+ +D + EI K++ Q RTVE AL ++ +EA K + +L +
Sbjct: 1567 TQVKSEIDRKIAEKDEEIEQLKRNYQ-RTVETMQSALDAEVRSRNEAIRLKKKMEGDLNE 1625
Query: 305 MKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDN--------------VVKKVQAAQS 350
++ + +A ++ K H+ + +G+L + + LD+ V ++ Q+
Sbjct: 1626 IEIQLSHANRQAAETLK-HLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQA 1684
Query: 351 EAKVVSQYHELVVQARDDFKREL-DSITPEVLPGWKGMSVSDLADKLSTD--DLNSLIAH 407
E + + E +AR ++EL DS L + S+ KL TD L S +
Sbjct: 1685 EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVED 1744
Query: 408 AHRRIDQLNRELAEQKAT-----------EKQHITLALEKQK--LEE-----KRAFDSAV 449
A R D N E +KA ++Q + LE+ K LE+ + D A
Sbjct: 1745 ASR--DARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1802
Query: 450 AKALEHHRSEIQAEQDRKIEEVRDAMENEMR--TQLRRQAAAHTDHLRDVLRVQEQELKS 507
AL+ + +IQ + R I E+ +E E + T+ + + ++++ E++ K+
Sbjct: 1803 QLALKGGKKQIQKLETR-IRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKN 1861
Query: 508 EFE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARK 565
Q+L +KL + ++R ++E + + +E+A + +AE + K
Sbjct: 1862 VLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNK 1920
Score = 33.9 bits (76), Expect = 0.58
Identities = 75/368 (20%), Positives = 155/368 (42%), Gaps = 33/368 (8%)
Query: 218 ESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK---KSAQW 274
E+L K + + LR T ++ I HS +L N + G + K
Sbjct: 654 ENLNKLMSN-LRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPN 712
Query: 275 RTVEGALKERRKAVDEAA---DALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAE--G 329
R + G K+R + ++ +A + +K+ EK+ + I+ + G A G
Sbjct: 713 RILYGDFKQRYRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLG 772
Query: 330 KLHNMIVD-LDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMS 388
L M D L ++ + QA + ++ ++V + F + + + + W M
Sbjct: 773 TLEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCIQYNIRSFMNVKHWPWMK 832
Query: 389 ----VSDLADKLSTD-DLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLE-EK 442
+ L T+ ++ ++ + D+L + A++K E++ +TL EK L+ +
Sbjct: 833 LFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQV 892
Query: 443 RAFDSAVAKALEHHRSEIQA--EQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRV 500
+A + A E I+A + + KI+EV + E+E ++ + A L D
Sbjct: 893 QAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDE--EEINAELTAKKRKLED---- 946
Query: 501 QEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAE 560
+ ELK + + +L L++ E + + ++ +V N T L G+++ + +
Sbjct: 947 ECSELKKDID-DLELTLAKVEKE-KHATENKVKNLT-------EELSGLDETIAKLTREK 997
Query: 561 EEARKAHQ 568
+ ++AHQ
Sbjct: 998 KALQEAHQ 1005
>gi|9910266 kinesin family member 15 [Homo sapiens]
Length = 1388
Score = 56.2 bits (134), Expect = 1e-07
Identities = 109/503 (21%), Positives = 210/503 (41%), Gaps = 70/503 (13%)
Query: 102 KSIQSGPLKISSVSEVMKESK-QPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPA 160
+S+Q L + ++ E K K Q SQL K +T T PT+A Q+ S P
Sbjct: 621 QSLQKANLNLENLLEATKACKRQEVSQLNKIHAETLKIITTPTKAYQLHSR-------PV 673
Query: 161 PAVQPE----ESLKTDHPEIGE----GKPTPALSEEASSSSIRER---PPEEVAARLAQ- 208
P + PE SL T + I + +P P E + +I E E+++A A+
Sbjct: 674 PKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKL 733
Query: 209 -QEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAG 267
+E+ + +K++ LE Q + + + + N+L
Sbjct: 734 DEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLNVL----------- 782
Query: 268 EKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAA 327
EK+ + +T LK V + L A +EL +K + K + K +
Sbjct: 783 EKQLQETQTKNDFLKSE---VHDLRVVLHSADKELSSVKLEYSSFKTNQ---EKEFNKLS 836
Query: 328 EGKLHNMIVDLDNV-VKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKG 386
E +H + + LDN+ ++ + +S+A + Y L ++ K E+D ++ + +
Sbjct: 837 ERHMH-VQLQLDNLRLENEKLLESKACLQDSYDNL----QEIMKFEIDQLSRNL----QN 887
Query: 387 MSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALE---KQKLEEKR 443
+ K ++L L+ R ++L+ + E K + I LE ++K +E
Sbjct: 888 FKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETA 947
Query: 444 AFDSAVAK---------ALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHL 494
+ +AK A E S ++ +D + V D M N+++ +LR T+ +
Sbjct: 948 KCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLM-NQIQ-ELRTSVCEKTETI 1005
Query: 495 RDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQ 554
D L+ + +++ ++ L ++ + L + +++VD LD+ RLR + + ++
Sbjct: 1006 -DTLKQELKDINCKYNSALVDREESRVL----IKKQEVD--ILDLKET-LRLRILSEDIE 1057
Query: 555 SHAVAEEEARKAHQLWLSVEALK 577
+ E+ A QL + EA K
Sbjct: 1058 RDMLCEDLAHATEQLNMLTEASK 1080
Score = 32.7 bits (73), Expect = 1.3
Identities = 66/404 (16%), Positives = 155/404 (38%), Gaps = 62/404 (15%)
Query: 200 EEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAA 259
E+V + L + ++ + L +++ LR + + I ++ +N N
Sbjct: 967 EKVISSLEKSRDSDKKVVADLMNQIQE-LRTSVCEKTETIDTLKQELKDINCKYNSALVD 1025
Query: 260 MDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKE--- 316
+ S + +K+ ++ L+ R + D D L + + +++ A KK
Sbjct: 1026 REESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGL 1085
Query: 317 VAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSI 376
+ A+ +T E + + L+ ++V+ ++E + E V+ + + D
Sbjct: 1086 LQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAE-----DPQ 1140
Query: 377 TPEVLPGWKGMSVSDLADKLSTDD------------LNSLIAHAHRRIDQLNRELAEQKA 424
+P+ P ++ + LA L T + L L+ + + N E+ K
Sbjct: 1141 SPKTPPHFQ----THLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKE 1196
Query: 425 TEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLR 484
++ L LE Q+L EK +Q + D +++ Q
Sbjct: 1197 QLREMENLRLESQQLIEKNWL--------------LQGQLD------------DIKRQKE 1230
Query: 485 RQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDINTA 542
H D+ Q+LK+E E+++ E+L++ ++ + ++ + + + N
Sbjct: 1231 NSDQNHPDN---------QQLKNEQEESIKERLAKSKIVEEMLKMKADLEEVQSALYNKE 1281
Query: 543 YARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAE 586
LR ++ ++ + + ++ QL +E + + +S E
Sbjct: 1282 MECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQE 1325
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 55.8 bits (133), Expect = 1e-07
Identities = 99/461 (21%), Positives = 179/461 (38%), Gaps = 101/461 (21%)
Query: 164 QPEESLKTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQ--VKIESLA 221
Q E+ L+ H ++GE +S + +R E V + QE +EQ +K +SL
Sbjct: 1754 QLEQQLQGLHRKVGE-----------TSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQ 1802
Query: 222 KSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGAL 281
L++A R A+A ++ ++A+ + A E EK A ++GAL
Sbjct: 1803 SQLDEAQR--------ALAQRDQELEALQQEQ---QQAQGQEERVKEKADA----LQGAL 1847
Query: 282 KERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNV 341
++ + E L KE+ +++ +E+A + A E L ++ +
Sbjct: 1848 EQAHMTLKERHGELQDHKEQARRLE--------EELAVEGRRVQALEEVLGDLRAESREQ 1899
Query: 342 VKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDL 401
K + A Q + +Q HE+ +A D + ++ E
Sbjct: 1900 EKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKE---------------------- 1937
Query: 402 NSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQ 461
R +L AE +++ Q + L+E A + E H E Q
Sbjct: 1938 ---------RDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLE-Q 1987
Query: 462 AEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELK------SEFEQNLSE 515
AE R +E ++ + AH+ L + LR+QE E++ E Q L +
Sbjct: 1988 AELSRSLEASTATLQASLDA-----CQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQ 2042
Query: 516 KLSEQELQFRR-----------LSQEQVDNF-----TLDINTAYARLRGIEQAVQ--SHA 557
L++++ + R L+Q +N L +RG+ Q+V+
Sbjct: 2043 ALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLT 2102
Query: 558 VAEEEAR----KAHQLWLSVEALKYSMKTSSAETPTIPLGS 594
+A++E + Q ++EAL +S KTS E ++ L S
Sbjct: 2103 LAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDS 2143
Score = 52.4 bits (124), Expect = 2e-06
Identities = 94/442 (21%), Positives = 186/442 (42%), Gaps = 51/442 (11%)
Query: 187 EEASSSSIRERPP-EEVAARLAQQEKQEQVKIESLAKSLEDA------LRQTASVTLQAI 239
+E ++RER +E+ L ++ + ++ +L ++LE + LRQ + A+
Sbjct: 511 QEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAAL 570
Query: 240 AAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAK 299
A ++ +++ N LK + + A K SA + AL + +++ LL+ +
Sbjct: 571 ARAEQSIAELSSSENTLKTEVADLRAAAVKLSA----LNEALALDKVGLNQQ---LLQLE 623
Query: 300 EELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYH 359
EE + + S +E AAE + + VDL K+ +A + +
Sbjct: 624 EENQSVCSRME---------------AAEQARNALQVDLAEAEKRREALWEKNTHLEAQL 668
Query: 360 ELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNREL 419
+ +A + + +L I E K +S S + +T L L A R+ + L R +
Sbjct: 669 QKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAV 728
Query: 420 AEQKATEKQHITLAL-------EKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVR 472
E++A ++ L + ++Q L E+ S+ + LE E Q +Q+ IE +
Sbjct: 729 QEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQ-QQNSVIEVTK 787
Query: 473 DAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQV 532
+E +++T ++V++ + + LK E + S+ E++ R+L+Q +
Sbjct: 788 GQLEVQIQT---------VTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQ 838
Query: 533 DNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPL 592
+ T A + + Q + E+ R HQ L+ + E
Sbjct: 839 EGKTALEQQKAAHEKEVNQLREKW----EKERSWHQQELAKALESLEREKMELEMRLKEQ 894
Query: 593 GSAVEAIKANCSDNEFTQALTA 614
+ +EAI+A + E TQA +A
Sbjct: 895 QTEMEAIQAQ-REEERTQAESA 915
Score = 50.4 bits (119), Expect = 6e-06
Identities = 98/494 (19%), Positives = 205/494 (41%), Gaps = 47/494 (9%)
Query: 115 SEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHP 174
+E ++ ++ A LQ+Q A A E +++ TL A + E+L+
Sbjct: 1392 NEEVESERERAQALQEQGELKVAQGKALQENLALLT---QTL---AEREEEVETLRGQIQ 1445
Query: 175 EIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 234
E+ + + + E S +++R E L Q++ QE K S+ + L A+++
Sbjct: 1446 ELEKQREMQKAALELLSLDLKKRNQE---VDLQQEQIQELEKCRSVLEHLPMAVQERE-- 1500
Query: 235 TLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADA 294
Q + Q ++ + + +++ + EKK + G +++ +K +
Sbjct: 1501 --QKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECL 1558
Query: 295 LLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKV 354
L+ +E KM+ + KE+ G + A L ++ +DL+ +++QA S+
Sbjct: 1559 ALELEENHHKME--CQQKLIKELEGQRETQRVA---LTHLTLDLEERSQELQAQSSQIHD 1613
Query: 355 VSQYHELVVQARDDFKRELDSITPEV--LPGWKGMSVSDLADK-----LSTDDLNSLIAH 407
+ + ++ + + +E+ S ++ L K DL + L + + L
Sbjct: 1614 LESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQ 1673
Query: 408 AHRRIDQLNRELAEQKATEKQH-ITLALEKQKLEEKRAFDSAVAKA----LEHHR----- 457
R+ L +L + K + ++ L ++Q ++E+ +KA LEH +
Sbjct: 1674 RTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRD 1733
Query: 458 ----SEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNL 513
E Q E +++E++D +E +++ R+ +L +EQE+ +Q L
Sbjct: 1734 KEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSL-----LLSQREQEI-VVLQQQL 1787
Query: 514 SEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEAR-KAHQLWLS 572
E + EL+ + L Q Q+D + L ++Q Q EE + KA L +
Sbjct: 1788 QEAREQGELKEQSL-QSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGA 1846
Query: 573 VEALKYSMKTSSAE 586
+E ++K E
Sbjct: 1847 LEQAHMTLKERHGE 1860
Score = 44.7 bits (104), Expect = 3e-04
Identities = 69/373 (18%), Positives = 159/373 (42%), Gaps = 43/373 (11%)
Query: 111 ISSVSEVMK----ESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPE 166
+SS E+++ E++Q S ++ KG T+A ++I L + + E
Sbjct: 762 LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLE---LDTE 818
Query: 167 ESLKTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQ-EKQEQVKIESLAKSLE 225
S + + A E ++ ++ E+ +L ++ EK+ + LAK+LE
Sbjct: 819 RSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALE 878
Query: 226 DALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWR-TVEGALKER 284
R+ + ++ + Q ++A+ A + +++ + ++ + R ++ L +
Sbjct: 879 SLEREKMELEMR-LKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT 937
Query: 285 RKAVDEAADALLKAKEELEKMK-----------SVIENAKKKEVAGAKPH---ITAAEGK 330
+K + +A+ L + +++++ K + ++ A+++ A+ H + A + +
Sbjct: 938 QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997
Query: 331 LHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQA--------------RDDFKRELDSI 376
+++ D ++ K+V+ +S+ LV Q + + +RE S+
Sbjct: 998 SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
Query: 377 TPEVLPGWKGMSVSDLADKLSTDDLNSLI-----AHAHRRIDQLNRELAEQKATEKQHIT 431
T ++ + + V AD + +L++L A ++ EL Q+ EK+
Sbjct: 1058 TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADF 1117
Query: 432 LALEKQKLEEKRA 444
LA E Q LEE A
Sbjct: 1118 LAQEAQLLEELEA 1130
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.126 0.340
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,968,790
Number of Sequences: 37866
Number of extensions: 1168279
Number of successful extensions: 8319
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 851
Number of HSP's that attempted gapping in prelim test: 6071
Number of HSP's gapped (non-prelim): 2394
length of query: 758
length of database: 18,247,518
effective HSP length: 110
effective length of query: 648
effective length of database: 14,082,258
effective search space: 9125303184
effective search space used: 9125303184
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.