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Search of human proteins with 154354962
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154354962 inner membrane protein, mitochondrial isoform 2
[Homo sapiens]
(757 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154354962 inner membrane protein, mitochondrial isoform 2 [Ho... 1456 0.0
gi|154354964 inner membrane protein, mitochondrial isoform 1 [Ho... 1451 0.0
gi|154354966 inner membrane protein, mitochondrial isoform 3 [Ho... 1424 0.0
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 71 3e-12
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 71 4e-12
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 71 4e-12
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 71 4e-12
gi|110611218 ribosome binding protein 1 [Homo sapiens] 69 2e-11
gi|110611220 ribosome binding protein 1 [Homo sapiens] 69 2e-11
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 65 2e-10
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 65 2e-10
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 65 2e-10
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 65 2e-10
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 65 2e-10
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 65 2e-10
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 65 2e-10
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 65 2e-10
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 65 3e-10
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 60 6e-09
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 59 2e-08
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 59 2e-08
gi|38044112 restin isoform b [Homo sapiens] 58 3e-08
gi|4506751 restin isoform a [Homo sapiens] 58 3e-08
gi|55770834 centromere protein F [Homo sapiens] 58 3e-08
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 58 3e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 58 4e-08
gi|42794779 myosin 18A isoform b [Homo sapiens] 57 5e-08
gi|28416946 myosin 18A isoform a [Homo sapiens] 57 5e-08
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 57 8e-08
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 57 8e-08
>gi|154354962 inner membrane protein, mitochondrial isoform 2 [Homo
sapiens]
Length = 757
Score = 1456 bits (3769), Expect = 0.0
Identities = 757/757 (100%), Positives = 757/757 (100%)
Query: 1 MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG 60
MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG
Sbjct: 1 MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG 60
Query: 61 TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE 120
TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE
Sbjct: 61 TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE 120
Query: 121 SKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGK 180
SKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGK
Sbjct: 121 SKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGK 180
Query: 181 PTPALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAA 240
PTPALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAA
Sbjct: 181 PTPALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAA 240
Query: 241 QNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEE 300
QNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEE
Sbjct: 241 QNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEE 300
Query: 301 LEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHEL 360
LEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHEL
Sbjct: 301 LEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHEL 360
Query: 361 VVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAE 420
VVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAE
Sbjct: 361 VVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAE 420
Query: 421 QKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRT 480
QKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRT
Sbjct: 421 QKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRT 480
Query: 481 QLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINT 540
QLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINT
Sbjct: 481 QLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINT 540
Query: 541 AYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKA 600
AYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKA
Sbjct: 541 AYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKA 600
Query: 601 NCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLS 660
NCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLS
Sbjct: 601 NCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLS 660
Query: 661 YLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVA 720
YLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVA
Sbjct: 661 YLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVA 720
Query: 721 QDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE 757
QDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE
Sbjct: 721 QDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE 757
>gi|154354964 inner membrane protein, mitochondrial isoform 1 [Homo
sapiens]
Length = 758
Score = 1451 bits (3757), Expect = 0.0
Identities = 757/758 (99%), Positives = 757/758 (99%), Gaps = 1/758 (0%)
Query: 1 MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG 60
MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG
Sbjct: 1 MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG 60
Query: 61 TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE 120
TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE
Sbjct: 61 TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE 120
Query: 121 SKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGK 180
SKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGK
Sbjct: 121 SKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGK 180
Query: 181 PTPALSE-ASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA 239
PTPALSE ASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA
Sbjct: 181 PTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA 240
Query: 240 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 299
AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE
Sbjct: 241 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 300
Query: 300 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE 359
ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE
Sbjct: 301 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE 360
Query: 360 LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA 419
LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA
Sbjct: 361 LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA 420
Query: 420 EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR 479
EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR
Sbjct: 421 EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR 480
Query: 480 TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN 539
TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN
Sbjct: 481 TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN 540
Query: 540 TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK 599
TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK
Sbjct: 541 TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK 600
Query: 600 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL 659
ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL
Sbjct: 601 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL 660
Query: 660 SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV 719
SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV
Sbjct: 661 SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV 720
Query: 720 AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE 757
AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE
Sbjct: 721 AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE 758
>gi|154354966 inner membrane protein, mitochondrial isoform 3 [Homo
sapiens]
Length = 747
Score = 1424 bits (3685), Expect = 0.0
Identities = 746/758 (98%), Positives = 746/758 (98%), Gaps = 12/758 (1%)
Query: 1 MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG 60
MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG
Sbjct: 1 MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGG 60
Query: 61 TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE 120
TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE
Sbjct: 61 TILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKE 120
Query: 121 SKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGK 180
SKQPASQLQKQKGDTPASATA GDTLSVPAPAVQPEESLKTDHPEIGEGK
Sbjct: 121 SKQPASQLQKQKGDTPASATA-----------GDTLSVPAPAVQPEESLKTDHPEIGEGK 169
Query: 181 PTPALSE-ASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA 239
PTPALSE ASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA
Sbjct: 170 PTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIA 229
Query: 240 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 299
AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE
Sbjct: 230 AQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 289
Query: 300 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE 359
ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE
Sbjct: 290 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE 349
Query: 360 LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA 419
LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA
Sbjct: 350 LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELA 409
Query: 420 EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR 479
EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR
Sbjct: 410 EQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR 469
Query: 480 TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN 539
TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN
Sbjct: 470 TQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDIN 529
Query: 540 TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK 599
TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK
Sbjct: 530 TAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIK 589
Query: 600 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL 659
ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL
Sbjct: 590 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFL 649
Query: 660 SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV 719
SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV
Sbjct: 650 SYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRV 709
Query: 720 AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE 757
AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE
Sbjct: 710 AQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE 747
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 71.2 bits (173), Expect = 3e-12
Identities = 133/606 (21%), Positives = 249/606 (41%), Gaps = 77/606 (12%)
Query: 162 AVQPEESLKTDHPEIGEGKPTPALSEASSSSIRERPPEEVAARLAQQEKQEQVK-IESLA 220
A Q +E+L+ P + + L E + R+ E A++E Q QV+ +E A
Sbjct: 811 AEQAQEALEQQLPTLRHERSQ--LQEQLAQLSRQLSGREQELEQARREAQRQVEALERAA 868
Query: 221 KSLEDALRQTASVTLQAIAAQNAA--VQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEG 278
+ E ++ A + +Q +AA+ + + K A++ S +++ AQ
Sbjct: 869 REKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ------ 922
Query: 279 ALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLD 338
L+ RR+ ++ ALL AKE L E+AG + I A + K +D +
Sbjct: 923 -LEARREQLEAEGQALLLAKETL-----------TGELAGLRQQIIATQEKAS---LDKE 967
Query: 339 NVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSV--SDLADKLS 396
+ +K+ A+ EA+ + + R + +L + E W+ + + L +L
Sbjct: 968 LMAQKLVQAEREAQASLR------EQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQ 1021
Query: 397 TDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLA------------LEKQKLEEK--- 441
+ L+A ++L+ E+A + + + LA EK L EK
Sbjct: 1022 REQ-EELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMG 1080
Query: 442 -RAFDSAVAKALEHHRSEIQA--EQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLR 498
R + ++ +E + + Q+ EQDR + ++R Q AAAH +R R
Sbjct: 1081 TRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVR---R 1137
Query: 499 VQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQA--VQSHA 556
+QEQ +++ + +E+ RL ++ D ++ A +LR ++ VQ
Sbjct: 1138 LQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQE 1197
Query: 557 VAE------EEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQA 610
E E A++ L S E L+ ++K + +E ++ L + + K + T
Sbjct: 1198 AGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEART-- 1255
Query: 611 LTAAIPPESLTRGVYSEETLRARFYA---VQKLARRVAMIDETRNSLYQYFLSYLQSLLL 667
A+ E+ +E R+R A +Q+L R++ M+D L + L L
Sbjct: 1256 ---AVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLAL 1312
Query: 668 FPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESR---RVAQDWL 724
+ + E + L AS + +L++A + + + +GE R R L
Sbjct: 1313 GERAEKESRRETL--GLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSL 1370
Query: 725 KEARMT 730
+EAR T
Sbjct: 1371 EEARGT 1376
Score = 48.1 bits (113), Expect = 3e-05
Identities = 97/431 (22%), Positives = 170/431 (39%), Gaps = 68/431 (15%)
Query: 188 ASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQA 247
A S +R EE+ ARL ++++ +I +L + ++ L S QA++ + + A
Sbjct: 1014 AQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTA 1073
Query: 248 VNAH--SNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMK 305
++ A + E+ +K+ AQ R++ +AL +L +
Sbjct: 1074 LSEKLMGTRHSLATISLEMERQKRDAQ---------SRQEQDRSTVNALTSELRDLRAQR 1124
Query: 306 SVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQAR 365
A +EV +L DL K+ + EA+ + L+ AR
Sbjct: 1125 EEAAAAHAQEVR-----------RLQEQARDLG---KQRDSCLREAEELRTQLRLLEDAR 1170
Query: 366 DDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAE----Q 421
D +REL ++ +G V + +L + + + L R E
Sbjct: 1171 DGLRRELLEAQRKLRESQEGREV----QRQEAGELRRSLGEGAKEREALRRSNEELRSAV 1226
Query: 422 KATEKQHITLALEKQKLEEKRAF----DSAVAKALEHHRSEIQ------AEQDRKIEEVR 471
K E + I+L L + E+K A +AV K R+ +Q E R+++E+R
Sbjct: 1227 KKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELR 1286
Query: 472 DAME--NEMRTQLRRQAA-----------AHTDHLRDVLRVQEQELKSEFEQNLSEKLSE 518
M+ + T+L R+ A A + R+ L ++++ LK E S ++
Sbjct: 1287 RQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGE----ASLEVMR 1342
Query: 519 QELQF-RRLSQEQVDNFTLDINTAYARL---RGIEQAVQSHAVAEEEARKAHQLWLSVEA 574
QELQ +R QEQ F L RG E+ HA E +A + EA
Sbjct: 1343 QELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAAR----AEA 1398
Query: 575 LKYSMKTSSAE 585
+ ++ S+AE
Sbjct: 1399 AELGLRLSAAE 1409
Score = 46.2 bits (108), Expect = 1e-04
Identities = 63/323 (19%), Positives = 137/323 (42%), Gaps = 39/323 (12%)
Query: 254 ILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKK 313
++ +A+ ++ + ++ + L RK + ++ +E+L++++ + A +
Sbjct: 523 LIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQ 582
Query: 314 KEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELD 373
A+ + + + N+ +Q AQ +A+ + Q E + A+++ +R+ D
Sbjct: 583 AH-EDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRD 641
Query: 374 SITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLAL 433
+ E + +V D A + + +HR+++QL E + LA
Sbjct: 642 RLEEE-----QEDAVQDGAR------VRRELERSHRQLEQL----------EGKRSVLAK 680
Query: 434 EKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHL 493
E ++ E + + L+ ++E+ AE K E R +E M T+LR + A+ D L
Sbjct: 681 ELVEVREALSRATLQRDMLQAEKAEV-AEALTKAEAGRVELELSM-TKLRAEEASLQDSL 738
Query: 494 RDVLRVQEQ---------ELKSEFEQNLS-----EKLSEQELQFRRLSQEQVDNFTLDIN 539
+ + E L ++ E+ S ++ +EQE R QE+++ L+
Sbjct: 739 SKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQE 798
Query: 540 TAYARLRG-IEQAVQSHAVAEEE 561
A L G + A Q+ E++
Sbjct: 799 VARQGLEGSLRVAEQAQEALEQQ 821
Score = 39.7 bits (91), Expect = 0.010
Identities = 68/332 (20%), Positives = 134/332 (40%), Gaps = 34/332 (10%)
Query: 184 ALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNA 243
AL + S R+ EV A Q + + + E ALR +A+A +A
Sbjct: 1681 ALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSA 1740
Query: 244 AVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVD-----------EAAD 292
++ + + L+ A+ E + + AL E RK E AD
Sbjct: 1741 SLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVAD 1800
Query: 293 ALLK---AKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQS 349
L+ A+ +L++++ V+ ++ E A + + + + L ++ + + ++
Sbjct: 1801 LELQRVEAEGQLQQLREVLRQRQEGEAAALNT-VQKLQDERRLLQERLGSLQRALAQLEA 1859
Query: 350 EAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTD----DLNSLIA 405
E + V + + + R +R LD + E L + +V A+K D +A
Sbjct: 1860 EKREVERSALRLEKDRVALRRTLDKVEREKLRSHED-TVRLSAEKGRLDRTLTGAELELA 1918
Query: 406 HAHRRIDQLNRELAEQKATEKQHITLALE----------KQKLEEKRAFDSAVAKALEHH 455
A R+I QL ++ E+ H LE +Q++E R+ + + LE
Sbjct: 1919 EAQRQIQQLEAQVV---VLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEA- 1974
Query: 456 RSEIQAEQDRKIEEVRDAMENEMRTQLRRQAA 487
R ++ R +EE ++ +++ +LRR +A
Sbjct: 1975 RERAHRQRVRGLEEQVSTLKGQLQQELRRSSA 2006
Score = 37.7 bits (86), Expect = 0.040
Identities = 88/446 (19%), Positives = 185/446 (41%), Gaps = 88/446 (19%)
Query: 181 PTPALSEASSSSI-------RERPPEEVAARLAQQE------KQEQVKIESLAKSLEDAL 227
P+PA S++S+ ++ R+ +++ R + +++ ES ++LE+ L
Sbjct: 511 PSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQL 570
Query: 228 RQTASVTLQAIAAQNAA---VQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERR 284
++ T A+ A A VQ + + + +L + + S +A + AQ + E L++ R
Sbjct: 571 QRLRDKTDGAMQAHEDAQREVQRLRSANELL--SREKSNLAHSLQVAQQQAEE--LRQER 626
Query: 285 KAVDEAADALLKAKEELEKMK--SVIENAK-KKEVAGAKPHITAAEGKLHNMIVDLDNVV 341
+ + A + L + ++ LE+ + +V + A+ ++E+ + + EGK + +L V
Sbjct: 627 EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVR 686
Query: 342 KKVQAA-------QSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMS-VSDLAD 393
+ + A Q+E V++ R + + + + E +S +S L +
Sbjct: 687 EALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNE 746
Query: 394 KLSTD--DLNSLIAHAHR------------------------RIDQLNRE---------- 417
L+ D DLN L+A R+++L E
Sbjct: 747 SLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEG 806
Query: 418 ---LAEQ--KATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRD 472
+AEQ +A E+Q TL E+ +L+E+ A S E + + E R++E +
Sbjct: 807 SLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALER 866
Query: 473 AMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVD 532
A R + A +H +++ E + + LSE+ + RL +E ++
Sbjct: 867 A--------AREKEALAKEHAGLAVQLVAAEREG---RTLSEEATR-----LRLEKEALE 910
Query: 533 NFTLDINTAYARLRGIEQAVQSHAVA 558
++ A+L + +++ A
Sbjct: 911 GSLFEVQRQLAQLEARREQLEAEGQA 936
Score = 32.7 bits (73), Expect = 1.3
Identities = 78/418 (18%), Positives = 166/418 (39%), Gaps = 81/418 (19%)
Query: 183 PALSEASSSSIRERPP---------EEVAARLAQQEKQEQVKIESLAKSLEDALR----- 228
PA AS S++E E++ A+ + + +K ++++ LE ALR
Sbjct: 69 PATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGE 128
Query: 229 ----QTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQW-RTVEGALKER 283
+ + Q++ + + ++ L+A + G+++ AQ + ++G + +
Sbjct: 129 LETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQE-----GQQRQAQLVQRLQGKILQY 183
Query: 284 RKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKK 343
+K E LL+ ELE+ + + + + + DL++ + +
Sbjct: 184 KKRCSELEQQLLERSGELEQQR--LRDTEHSQ--------------------DLESALIR 221
Query: 344 VQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSL 403
++ Q + ++Q + ++ + +LD G ++S+ K++ D
Sbjct: 222 LEEEQQRSASLAQVNAML-------REQLDQA------GSANQALSEDIRKVTNDWTRCR 268
Query: 404 IAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQ 463
HR E + +H L L +++ R S V E ++ E
Sbjct: 269 KELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGEL 328
Query: 464 DRKIEEVRDA----------MENEMRTQLRRQA---AAHTDHLRD-VLR---VQEQELKS 506
R V++A E+ L +QA A + LRD VLR + +Q+++S
Sbjct: 329 ARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQS 388
Query: 507 EFEQ-NLSEKLSEQELQFRRLSQEQV--DNFTLDINTAYARLRGIEQAVQSHAVAEEE 561
+ ++ +LS +++E L +RL ++ + D D+ L + +Q A E E
Sbjct: 389 DLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLR--LQEQAALETE 444
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/493 (23%), Positives = 208/493 (42%), Gaps = 57/493 (11%)
Query: 115 SEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESL-KTDH 173
++++K ++ + L + + D + A T+A + G+ L A + E++L T+
Sbjct: 1132 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELE--ALRGELEDTLDSTNA 1189
Query: 174 PEIGEGKPTPALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 233
+ K ++E + E E A + +Q + + LA+ LE A R +
Sbjct: 1190 QQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQA--LGELAEQLEQARRGKGAW 1247
Query: 234 TLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADA 293
+A + A V + A + L+ A E + Q + V+G + +A EAA+
Sbjct: 1248 EKTRLALE-AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK 1306
Query: 294 LLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-------KVQA 346
L +A+ ELE + + A+ K + +K +++ E +LH+ L + +V+A
Sbjct: 1307 LQRAQAELENVSGALNEAESKTIRLSK-ELSSTEAQLHDAQELLQEETRAKLALGSRVRA 1365
Query: 347 AQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAH 406
++EA + + E AR+ REL + + L W+ + + ++
Sbjct: 1366 MEAEAAGLREQLEEEAAARERAGRELQTAQAQ-LSEWRRRQEEEAGALEAGEEAR---RR 1421
Query: 407 AHRRIDQLNRELAEQKAT-------------EKQHITLALEKQK-----LEEK-RAFDSA 447
A R + L + LAE+ T E T+ LE+Q+ LE+K R FD
Sbjct: 1422 AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL 1481
Query: 448 VAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 507
+A E + ++A ++R+ E + E E R +A R+ L Q + L++E
Sbjct: 1482 LA---EEKAAVLRAVEERERAEA-EGREREARALSLTRALEEEQEAREELERQNRALRAE 1537
Query: 508 FEQNLSEK----LSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEAR 563
E LS K S EL+ EQ N LR ++ A E+A+
Sbjct: 1538 LEALLSSKDDVGKSVHELERACRVAEQAAN----------DLRAQVTELEDELTAAEDAK 1587
Query: 564 KAHQLWLSVEALK 576
+L ++V+ALK
Sbjct: 1588 L--RLEVTVQALK 1598
Score = 40.4 bits (93), Expect = 0.006
Identities = 89/452 (19%), Positives = 176/452 (38%), Gaps = 67/452 (14%)
Query: 149 ISAAGDTLSVPAPAVQPEESLKTDHP-EIGEGKPTPALSEASSSSIRER---------PP 198
++ + L A +Q + L+ E+GE + A E + + E+
Sbjct: 872 VTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEA 931
Query: 199 EEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAA 258
EE RLA ++++ ++ + L + + + + + Q +Q + AH + A
Sbjct: 932 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH-IQELEAHLEAEEGA 990
Query: 259 MDNSEIAGEKKSAQWRTVEGAL-----------KERRKAVDEAADALLKAKEELEKMKSV 307
++ A+ + E L KER+ D A+ +A EE EK+KS+
Sbjct: 991 RQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSL 1050
Query: 308 IENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDD 367
+ K E I D+++ ++K + + E +
Sbjct: 1051 NKLRLKYEAT----------------IADMEDRLRKEEKGRQEL--------------EK 1080
Query: 368 FKRELDSITPEVLPGW--KGMSVSDLADKL--STDDLNSLIAHAHRRIDQLNRELAEQKA 423
KR LD + E+ + +L +L ++L + +A A D+ K+
Sbjct: 1081 LKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE---DEGGARAQLLKS 1137
Query: 424 TEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDA--MENEMRTQ 481
+ LA ++ LE +R + K E++A + ++E+ D+ + E+R++
Sbjct: 1138 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRG-ELEDTLDSTNAQQELRSK 1196
Query: 482 LRRQAAAHTDHLRDVLRVQE---QELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDI 538
++ L + R+ E QEL+ Q L E L+EQ Q RR + + L +
Sbjct: 1197 REQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE-LAEQLEQARR-GKGAWEKTRLAL 1254
Query: 539 NTAYARLRGIEQAVQSHAVAEEEARKAHQLWL 570
+ LR ++Q+ E+ R+ +L L
Sbjct: 1255 EAEVSELRAELSSLQTARQEGEQRRRRLELQL 1286
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/493 (23%), Positives = 208/493 (42%), Gaps = 57/493 (11%)
Query: 115 SEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESL-KTDH 173
++++K ++ + L + + D + A T+A + G+ L A + E++L T+
Sbjct: 1124 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELE--ALRGELEDTLDSTNA 1181
Query: 174 PEIGEGKPTPALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 233
+ K ++E + E E A + +Q + + LA+ LE A R +
Sbjct: 1182 QQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQA--LGELAEQLEQARRGKGAW 1239
Query: 234 TLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADA 293
+A + A V + A + L+ A E + Q + V+G + +A EAA+
Sbjct: 1240 EKTRLALE-AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK 1298
Query: 294 LLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-------KVQA 346
L +A+ ELE + + A+ K + +K +++ E +LH+ L + +V+A
Sbjct: 1299 LQRAQAELENVSGALNEAESKTIRLSK-ELSSTEAQLHDAQELLQEETRAKLALGSRVRA 1357
Query: 347 AQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAH 406
++EA + + E AR+ REL + + L W+ + + ++
Sbjct: 1358 MEAEAAGLREQLEEEAAARERAGRELQTAQAQ-LSEWRRRQEEEAGALEAGEEAR---RR 1413
Query: 407 AHRRIDQLNRELAEQKAT-------------EKQHITLALEKQK-----LEEK-RAFDSA 447
A R + L + LAE+ T E T+ LE+Q+ LE+K R FD
Sbjct: 1414 AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL 1473
Query: 448 VAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 507
+A E + ++A ++R+ E + E E R +A R+ L Q + L++E
Sbjct: 1474 LA---EEKAAVLRAVEERERAEA-EGREREARALSLTRALEEEQEAREELERQNRALRAE 1529
Query: 508 FEQNLSEK----LSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEAR 563
E LS K S EL+ EQ N LR ++ A E+A+
Sbjct: 1530 LEALLSSKDDVGKSVHELERACRVAEQAAN----------DLRAQVTELEDELTAAEDAK 1579
Query: 564 KAHQLWLSVEALK 576
+L ++V+ALK
Sbjct: 1580 L--RLEVTVQALK 1590
Score = 40.4 bits (93), Expect = 0.006
Identities = 89/452 (19%), Positives = 176/452 (38%), Gaps = 67/452 (14%)
Query: 149 ISAAGDTLSVPAPAVQPEESLKTDHP-EIGEGKPTPALSEASSSSIRER---------PP 198
++ + L A +Q + L+ E+GE + A E + + E+
Sbjct: 864 VTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEA 923
Query: 199 EEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAA 258
EE RLA ++++ ++ + L + + + + + Q +Q + AH + A
Sbjct: 924 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH-IQELEAHLEAEEGA 982
Query: 259 MDNSEIAGEKKSAQWRTVEGAL-----------KERRKAVDEAADALLKAKEELEKMKSV 307
++ A+ + E L KER+ D A+ +A EE EK+KS+
Sbjct: 983 RQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSL 1042
Query: 308 IENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDD 367
+ K E I D+++ ++K + + E +
Sbjct: 1043 NKLRLKYEAT----------------IADMEDRLRKEEKGRQEL--------------EK 1072
Query: 368 FKRELDSITPEVLPGW--KGMSVSDLADKL--STDDLNSLIAHAHRRIDQLNRELAEQKA 423
KR LD + E+ + +L +L ++L + +A A D+ K+
Sbjct: 1073 LKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE---DEGGARAQLLKS 1129
Query: 424 TEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDA--MENEMRTQ 481
+ LA ++ LE +R + K E++A + ++E+ D+ + E+R++
Sbjct: 1130 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRG-ELEDTLDSTNAQQELRSK 1188
Query: 482 LRRQAAAHTDHLRDVLRVQE---QELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDI 538
++ L + R+ E QEL+ Q L E L+EQ Q RR + + L +
Sbjct: 1189 REQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE-LAEQLEQARR-GKGAWEKTRLAL 1246
Query: 539 NTAYARLRGIEQAVQSHAVAEEEARKAHQLWL 570
+ LR ++Q+ E+ R+ +L L
Sbjct: 1247 EAEVSELRAELSSLQTARQEGEQRRRRLELQL 1278
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/493 (23%), Positives = 208/493 (42%), Gaps = 57/493 (11%)
Query: 115 SEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESL-KTDH 173
++++K ++ + L + + D + A T+A + G+ L A + E++L T+
Sbjct: 1165 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELE--ALRGELEDTLDSTNA 1222
Query: 174 PEIGEGKPTPALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASV 233
+ K ++E + E E A + +Q + + LA+ LE A R +
Sbjct: 1223 QQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQA--LGELAEQLEQARRGKGAW 1280
Query: 234 TLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADA 293
+A + A V + A + L+ A E + Q + V+G + +A EAA+
Sbjct: 1281 EKTRLALE-AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK 1339
Query: 294 LLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-------KVQA 346
L +A+ ELE + + A+ K + +K +++ E +LH+ L + +V+A
Sbjct: 1340 LQRAQAELENVSGALNEAESKTIRLSK-ELSSTEAQLHDAQELLQEETRAKLALGSRVRA 1398
Query: 347 AQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAH 406
++EA + + E AR+ REL + + L W+ + + ++
Sbjct: 1399 MEAEAAGLREQLEEEAAARERAGRELQTAQAQ-LSEWRRRQEEEAGALEAGEEAR---RR 1454
Query: 407 AHRRIDQLNRELAEQKAT-------------EKQHITLALEKQK-----LEEK-RAFDSA 447
A R + L + LAE+ T E T+ LE+Q+ LE+K R FD
Sbjct: 1455 AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL 1514
Query: 448 VAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 507
+A E + ++A ++R+ E + E E R +A R+ L Q + L++E
Sbjct: 1515 LA---EEKAAVLRAVEERERAEA-EGREREARALSLTRALEEEQEAREELERQNRALRAE 1570
Query: 508 FEQNLSEK----LSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEAR 563
E LS K S EL+ EQ N LR ++ A E+A+
Sbjct: 1571 LEALLSSKDDVGKSVHELERACRVAEQAAN----------DLRAQVTELEDELTAAEDAK 1620
Query: 564 KAHQLWLSVEALK 576
+L ++V+ALK
Sbjct: 1621 L--RLEVTVQALK 1631
Score = 40.4 bits (93), Expect = 0.006
Identities = 89/452 (19%), Positives = 176/452 (38%), Gaps = 67/452 (14%)
Query: 149 ISAAGDTLSVPAPAVQPEESLKTDHP-EIGEGKPTPALSEASSSSIRER---------PP 198
++ + L A +Q + L+ E+GE + A E + + E+
Sbjct: 905 VTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEA 964
Query: 199 EEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAA 258
EE RLA ++++ ++ + L + + + + + Q +Q + AH + A
Sbjct: 965 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH-IQELEAHLEAEEGA 1023
Query: 259 MDNSEIAGEKKSAQWRTVEGAL-----------KERRKAVDEAADALLKAKEELEKMKSV 307
++ A+ + E L KER+ D A+ +A EE EK+KS+
Sbjct: 1024 RQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSL 1083
Query: 308 IENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDD 367
+ K E I D+++ ++K + + E +
Sbjct: 1084 NKLRLKYEAT----------------IADMEDRLRKEEKGRQEL--------------EK 1113
Query: 368 FKRELDSITPEVLPGW--KGMSVSDLADKL--STDDLNSLIAHAHRRIDQLNRELAEQKA 423
KR LD + E+ + +L +L ++L + +A A D+ K+
Sbjct: 1114 LKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE---DEGGARAQLLKS 1170
Query: 424 TEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDA--MENEMRTQ 481
+ LA ++ LE +R + K E++A + ++E+ D+ + E+R++
Sbjct: 1171 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRG-ELEDTLDSTNAQQELRSK 1229
Query: 482 LRRQAAAHTDHLRDVLRVQE---QELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDI 538
++ L + R+ E QEL+ Q L E L+EQ Q RR + + L +
Sbjct: 1230 REQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE-LAEQLEQARR-GKGAWEKTRLAL 1287
Query: 539 NTAYARLRGIEQAVQSHAVAEEEARKAHQLWL 570
+ LR ++Q+ E+ R+ +L L
Sbjct: 1288 EAEVSELRAELSSLQTARQEGEQRRRRLELQL 1319
>gi|110611218 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 68.6 bits (166), Expect = 2e-11
Identities = 135/615 (21%), Positives = 236/615 (38%), Gaps = 64/615 (10%)
Query: 85 LFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEV--MKESKQPASQLQKQKGDTPASATAP 142
L E V PA P P + P+ ++ V+ V M + K +S K+K + + P
Sbjct: 96 LREPVRAPAVAVAPTPVQP----PIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEP 151
Query: 143 TEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALSEASSSSIRERPPEEVA 202
++ + S T P+E TD + E A ++ S S ++ PP +
Sbjct: 152 AVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPP-DAD 210
Query: 203 ARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNS 262
L K + S+ + +A R L I ++ A + H KA
Sbjct: 211 GPLYLPYKTLVSTVGSMVFNEGEAQR------LIEILSEKAGIIQDTWH----KATQKGD 260
Query: 263 EIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAK-KKEVAGAKP 321
+A K+ + + A ++ AV ++ L + EK K+ AK KK++ +
Sbjct: 261 PVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQ 320
Query: 322 HITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLP 381
ITA + + M VK+VQ Q + + + + E + ++ +SI + L
Sbjct: 321 EITAVQAR---MQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDAL- 376
Query: 382 GWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEK 441
+ S + K N+ +A + + ++++EL E+ +Q E++
Sbjct: 377 ---NQATSQVESK-----QNAELAKLRQELSKVSKELVEKSEAVRQD----------EQQ 418
Query: 442 RAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQE 501
R A A A E ++QA R+ EE +E+ +L ++H D + QE
Sbjct: 419 RKALEAKAAAFEKQVLQLQASH-RESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQE 477
Query: 502 QELKSEFEQNLSEKLSEQELQFRRLSQE------QVDNFTLDINTAYARLRGIE---QAV 552
Q+ + L KL E + R +E Q+ + + R+R IE +A
Sbjct: 478 QQQQM---AELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAG 534
Query: 553 QSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSD--NEFTQA 610
Q+ + +A +A + + S E I L AVE K +D + +A
Sbjct: 535 QARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKA 594
Query: 611 LTAAIPPE--------SLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYL 662
+ A E SLT+ E A Q + +A++ E Q + +L
Sbjct: 595 MEALATAEQACKEKLHSLTQAKEESEKQLCLIEA-QTMEALLALLPELSVLAQQNYTEWL 653
Query: 663 QSLLLFPPQQLKPPP 677
Q L P LK PP
Sbjct: 654 QDLKEKGPTLLKHPP 668
>gi|110611220 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 68.6 bits (166), Expect = 2e-11
Identities = 135/615 (21%), Positives = 236/615 (38%), Gaps = 64/615 (10%)
Query: 85 LFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEV--MKESKQPASQLQKQKGDTPASATAP 142
L E V PA P P + P+ ++ V+ V M + K +S K+K + + P
Sbjct: 96 LREPVRAPAVAVAPTPVQP----PIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEP 151
Query: 143 TEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALSEASSSSIRERPPEEVA 202
++ + S T P+E TD + E A ++ S S ++ PP +
Sbjct: 152 AVSSVVNSIQVLTSKAAILETAPKEGRNTDVAQSPEAPKQEAPAKKKSGSKKKGPP-DAD 210
Query: 203 ARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNS 262
L K + S+ + +A R L I ++ A + H KA
Sbjct: 211 GPLYLPYKTLVSTVGSMVFNEGEAQR------LIEILSEKAGIIQDTWH----KATQKGD 260
Query: 263 EIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAK-KKEVAGAKP 321
+A K+ + + A ++ AV ++ L + EK K+ AK KK++ +
Sbjct: 261 PVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQ 320
Query: 322 HITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLP 381
ITA + + M VK+VQ Q + + + + E + ++ +SI + L
Sbjct: 321 EITAVQAR---MQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDAL- 376
Query: 382 GWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEK 441
+ S + K N+ +A + + ++++EL E+ +Q E++
Sbjct: 377 ---NQATSQVESK-----QNAELAKLRQELSKVSKELVEKSEAVRQD----------EQQ 418
Query: 442 RAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQE 501
R A A A E ++QA R+ EE +E+ +L ++H D + QE
Sbjct: 419 RKALEAKAAAFEKQVLQLQASH-RESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQE 477
Query: 502 QELKSEFEQNLSEKLSEQELQFRRLSQE------QVDNFTLDINTAYARLRGIE---QAV 552
Q+ + L KL E + R +E Q+ + + R+R IE +A
Sbjct: 478 QQQQM---AELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAG 534
Query: 553 QSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSD--NEFTQA 610
Q+ + +A +A + + S E I L AVE K +D + +A
Sbjct: 535 QARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKA 594
Query: 611 LTAAIPPE--------SLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYL 662
+ A E SLT+ E A Q + +A++ E Q + +L
Sbjct: 595 MEALATAEQACKEKLHSLTQAKEESEKQLCLIEA-QTMEALLALLPELSVLAQQNYTEWL 653
Query: 663 QSLLLFPPQQLKPPP 677
Q L P LK PP
Sbjct: 654 QDLKEKGPTLLKHPP 668
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 65.1 bits (157), Expect = 2e-10
Identities = 116/544 (21%), Positives = 211/544 (38%), Gaps = 66/544 (12%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPE 175
E+ + +Q S L + +G+ A+ A EA + A + V+ E LK E
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123
Query: 176 IGEGKPTPALSEASSSSIRERPPEEVAARLAQQE----KQEQV---KIESLAKSLEDALR 228
+ + A ++A++ +R+ +E AAR AQ E +Q+Q ++E K E LR
Sbjct: 2124 QAQAR---AQAQAAAEKLRKEAEQE-AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179
Query: 229 QTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVD 288
Q A V Q + ++ + N+L + + + + Q R V+
Sbjct: 2180 QKAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-----------RSQVE 2227
Query: 289 EAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQ 348
E ++ EEL K+K+ IE + + + D DN + +Q
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALI-----------------LRDKDNTQRFLQEEA 2270
Query: 349 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHA 407
+ K V++ + A + R L + E L + ++ L +K+ + + L A A
Sbjct: 2271 EKMKQVAEEAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2329
Query: 408 HRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKI 467
+ Q +ELA+++A Q + +Q EE + F ++AE+ R++
Sbjct: 2330 E--LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQL 2376
Query: 468 EEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQF 523
E +A ++R +A A + R Q +E+ + + +L+ QE +Q
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQT 2433
Query: 524 RRLSQEQVDNFTLDINTAYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSM 579
+ ++Q D+ + A A L ++ +Q A + EE + Q L E
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493
Query: 580 KTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQK 639
S + + +E KA + A E R E R R A +
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553
Query: 640 LARR 643
ARR
Sbjct: 2554 EARR 2557
Score = 62.0 bits (149), Expect = 2e-09
Identities = 120/586 (20%), Positives = 225/586 (38%), Gaps = 81/586 (13%)
Query: 111 ISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAA---GDTLSVPAPAVQPEE 167
+ ++ E+ ++++ +L++ + + E AQ + A S Q E
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1594
Query: 168 SLKTDH---PEIGEGKPTPALSEASSSSIRERPPEEV----------------AARLAQQ 208
SL+ +H ++ E A +A + RE E+ A +AQQ
Sbjct: 1595 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 209 EKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK 268
+ Q + E + E R+ QA+ + E+A ++
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------ELAEQE 1693
Query: 269 KSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKPHITA 325
Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752
Query: 326 AEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKG 385
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1753 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL------ 1806
Query: 386 MSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKR 442
++++ A + L+ +D A A R + + + E K +AL++++ E +R
Sbjct: 1807 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENER 1865
Query: 443 AFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQE 501
A +A + R E QA Q + IEE + ++L RQ D LR +V+E
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925
Query: 502 Q--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------YARLR 546
+ LK+ FE+ + K +E EL+ R+ D ++ A R R
Sbjct: 1926 EILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1984
Query: 547 GIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAVEAIK 599
E+ VQ AEEEA + + L VE LK ++ + + L A EA +
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2044
Query: 600 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 645
E A + L + + E+++ + + ARR A
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Score = 60.5 bits (145), Expect = 6e-09
Identities = 93/422 (22%), Positives = 168/422 (39%), Gaps = 68/422 (16%)
Query: 200 EVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAV----------- 248
++ RLAQ K ++E +ED LRQ V + +A + + +A
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 249 ----NAHSNILKAAMDNSEIAGEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKE 299
NA + E A +++ A + R E +++ A +EAA A E
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Query: 300 ELEKMKSVIENAK----------------------KKEVAGAKPHITAAEGKLHNMIVDL 337
E+E++K+ +E A+ K+ A K H A + K + L
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 338 DNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-- 395
+ + EA+ + E +AR +RE +V + A++L
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV----------EEAERLKQ 2119
Query: 396 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----A 451
S ++ A A ++L +E AEQ+A + E+ L +K+A D+ + K A
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKE-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFA 2174
Query: 452 LEHHRSEIQAEQD----RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 507
+ R + Q EQ+ R E D +N + +L+R A T+ R +V+E+
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 508 FE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 566
+ + LS+ + E + R L DN + +++ + + +VA +EA +
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294
Query: 567 QL 568
QL
Sbjct: 2295 QL 2296
Score = 57.0 bits (136), Expect = 6e-08
Identities = 87/390 (22%), Positives = 164/390 (42%), Gaps = 78/390 (20%)
Query: 184 ALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNA 243
A +E + +++R EEV R +Q K S+ + L+ LRQ++ +QA A Q
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEAEIQAKARQAE 1441
Query: 244 AVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 299
A + + +++ ++ +E Q EG L+ R +EA +A+E
Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEEAEAQKRQAQE 1494
Query: 300 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQSEAKVVSQYH 358
E E+++ +++ +++ V+L + VK + +AA+ + + +
Sbjct: 1495 EAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAREKQRALQALE 1539
Query: 359 ELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNREL 418
EL +QA + +R + EV + + A + + +L S A + QL R L
Sbjct: 1540 ELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 419 AEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEM 478
E+ H+ +A +++ E R++ QAE +R EE +E
Sbjct: 1597 QEE------HVAVAQLREEAER---------------RAQQQAEAERAREEAERELE--- 1632
Query: 479 RTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDI 538
R QL+ A LR+Q +E+ + + L++ E + ++ E+
Sbjct: 1633 RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEAER-------- 1671
Query: 539 NTAYARLRGIEQAVQSHAVAEEEARKAHQL 568
A R + EQAV+ +AE+E K QL
Sbjct: 1672 -EARRRGKAEEQAVRQRELAEQELEKQRQL 1700
Score = 46.2 bits (108), Expect = 1e-04
Identities = 111/511 (21%), Positives = 191/511 (37%), Gaps = 94/511 (18%)
Query: 166 EESLKTDHPEIGEGKPTPALS---EASSSSIRE-------------------RPPEEVAA 203
EE L+ ++ E + PA EA+ +S+++ R +EV
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1161
Query: 204 RLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQA------VNAHSNILKA 257
RL Q+ + V++E + + L + +V Q Q Q ++ L A
Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221
Query: 258 AMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVA 317
+ ++ E+ A A++E+ + ALL EE+E+ +E ++
Sbjct: 1222 WLQDARRRQEQIQAMPLADSQAVREQLRQ----EQALL---EEIERHGEKVEECQRF--- 1271
Query: 318 GAKPHITAAEGKLHNMIVDLDNVVKKVQ----AAQSEAKVVSQYHELVVQARDDFKRELD 373
AK +I A + +L V K Q A+ ++ V E V+Q D +
Sbjct: 1272 -AKQYINAIKD------YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1324
Query: 374 SITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLAL 433
+T T I+ RR+++ R LAEQ+ E
Sbjct: 1325 ELTT------------------LTSQYIKFISETLRRMEEEER-LAEQQRAE-------- 1357
Query: 434 EKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ----LRRQAAAH 489
E+++L E A ALE R +A K + R+A E + R Q R +AA
Sbjct: 1358 ERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1410
Query: 490 TDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDINTAYARLRG 547
+ ++ + Q+L+ E + K + E + R +E++ L + + G
Sbjct: 1411 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470
Query: 548 IEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAVEA-IKANCS 603
E +Q+ A AEE + Q E L+ ++ S + L S V+A +A
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1530
Query: 604 DNEFTQAL-TAAIPPESLTRGVYSEETLRAR 633
QAL + E R + E RAR
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Score = 40.0 bits (92), Expect = 0.008
Identities = 73/349 (20%), Positives = 144/349 (41%), Gaps = 47/349 (13%)
Query: 185 LSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTLQAIAAQNA 243
+ + + + R + AARL Q +++ + +LA K L++ ++ T A+
Sbjct: 2273 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332
Query: 244 AVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAADALLKAKEE 300
Q A + D ++A E+ RT+E ER++ ++ +A+A E
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAEA-----ER 2384
Query: 301 LEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQSEAKVVSQY 357
L+ + + A+ + A+ AE KLH + V VQ + + +
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444
Query: 358 HELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDLADKLSTDD 399
E + +A + +RE + + E +L + + S L++K S
Sbjct: 2445 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 400 LNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHR 456
I +++QL ++ A+Q E+Q ++Q++E++R VA E R
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLVASMEEARR 2557
Query: 457 SEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 503
+ +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2558 RQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2604
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 65.1 bits (157), Expect = 2e-10
Identities = 116/544 (21%), Positives = 211/544 (38%), Gaps = 66/544 (12%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPE 175
E+ + +Q S L + +G+ A+ A EA + A + V+ E LK E
Sbjct: 2068 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2127
Query: 176 IGEGKPTPALSEASSSSIRERPPEEVAARLAQQE----KQEQV---KIESLAKSLEDALR 228
+ + A ++A++ +R+ +E AAR AQ E +Q+Q ++E K E LR
Sbjct: 2128 QAQAR---AQAQAAAEKLRKEAEQE-AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2183
Query: 229 QTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVD 288
Q A V Q + ++ + N+L + + + + Q R V+
Sbjct: 2184 QKAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-----------RSQVE 2231
Query: 289 EAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQ 348
E ++ EEL K+K+ IE + + + D DN + +Q
Sbjct: 2232 EELFSVRVQMEELSKLKARIEAENRALI-----------------LRDKDNTQRFLQEEA 2274
Query: 349 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHA 407
+ K V++ + A + R L + E L + ++ L +K+ + + L A A
Sbjct: 2275 EKMKQVAEEAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2333
Query: 408 HRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKI 467
+ Q +ELA+++A Q + +Q EE + F ++AE+ R++
Sbjct: 2334 E--LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQL 2380
Query: 468 EEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQF 523
E +A ++R +A A + R Q +E+ + + +L+ QE +Q
Sbjct: 2381 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQT 2437
Query: 524 RRLSQEQVDNFTLDINTAYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSM 579
+ ++Q D+ + A A L ++ +Q A + EE + Q L E
Sbjct: 2438 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2497
Query: 580 KTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQK 639
S + + +E KA + A E R E R R A +
Sbjct: 2498 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2557
Query: 640 LARR 643
ARR
Sbjct: 2558 EARR 2561
Score = 62.0 bits (149), Expect = 2e-09
Identities = 120/586 (20%), Positives = 225/586 (38%), Gaps = 81/586 (13%)
Query: 111 ISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAA---GDTLSVPAPAVQPEE 167
+ ++ E+ ++++ +L++ + + E AQ + A S Q E
Sbjct: 1539 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1598
Query: 168 SLKTDH---PEIGEGKPTPALSEASSSSIRERPPEEV----------------AARLAQQ 208
SL+ +H ++ E A +A + RE E+ A +AQQ
Sbjct: 1599 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1658
Query: 209 EKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK 268
+ Q + E + E R+ QA+ + E+A ++
Sbjct: 1659 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------ELAEQE 1697
Query: 269 KSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKPHITA 325
Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1698 LEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1756
Query: 326 AEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKG 385
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1757 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL------ 1810
Query: 386 MSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKR 442
++++ A + L+ +D A A R + + + E K +AL++++ E +R
Sbjct: 1811 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENER 1869
Query: 443 AFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQE 501
A +A + R E QA Q + IEE + ++L RQ D LR +V+E
Sbjct: 1870 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1929
Query: 502 Q--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------YARLR 546
+ LK+ FE+ + K +E EL+ R+ D ++ A R R
Sbjct: 1930 EILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1988
Query: 547 GIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAVEAIK 599
E+ VQ AEEEA + + L VE LK ++ + + L A EA +
Sbjct: 1989 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2048
Query: 600 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 645
E A + L + + E+++ + + ARR A
Sbjct: 2049 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2094
Score = 60.5 bits (145), Expect = 6e-09
Identities = 93/422 (22%), Positives = 168/422 (39%), Gaps = 68/422 (16%)
Query: 200 EVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAV----------- 248
++ RLAQ K ++E +ED LRQ V + +A + + +A
Sbjct: 1894 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1953
Query: 249 ----NAHSNILKAAMDNSEIAGEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKE 299
NA + E A +++ A + R E +++ A +EAA A E
Sbjct: 1954 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2013
Query: 300 ELEKMKSVIENAK----------------------KKEVAGAKPHITAAEGKLHNMIVDL 337
E+E++K+ +E A+ K+ A K H A + K + L
Sbjct: 2014 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2073
Query: 338 DNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-- 395
+ + EA+ + E +AR +RE +V + A++L
Sbjct: 2074 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV----------EEAERLKQ 2123
Query: 396 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----A 451
S ++ A A ++L +E AEQ+A + E+ L +K+A D+ + K A
Sbjct: 2124 SAEEQAQARAQAQAAAEKLRKE-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFA 2178
Query: 452 LEHHRSEIQAEQD----RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 507
+ R + Q EQ+ R E D +N + +L+R A T+ R +V+E+
Sbjct: 2179 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2238
Query: 508 FE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 566
+ + LS+ + E + R L DN + +++ + + +VA +EA +
Sbjct: 2239 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2298
Query: 567 QL 568
QL
Sbjct: 2299 QL 2300
Score = 57.0 bits (136), Expect = 6e-08
Identities = 87/390 (22%), Positives = 164/390 (42%), Gaps = 78/390 (20%)
Query: 184 ALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNA 243
A +E + +++R EEV R +Q K S+ + L+ LRQ++ +QA A Q
Sbjct: 1388 AQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEAEIQAKARQAE 1445
Query: 244 AVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 299
A + + +++ ++ +E Q EG L+ R +EA +A+E
Sbjct: 1446 AAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEEAEAQKRQAQE 1498
Query: 300 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQSEAKVVSQYH 358
E E+++ +++ +++ V+L + VK + +AA+ + + +
Sbjct: 1499 EAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAREKQRALQALE 1543
Query: 359 ELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNREL 418
EL +QA + +R + EV + + A + + +L S A + QL R L
Sbjct: 1544 ELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600
Query: 419 AEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEM 478
E+ H+ +A +++ E R++ QAE +R EE +E
Sbjct: 1601 QEE------HVAVAQLREEAER---------------RAQQQAEAERAREEAERELE--- 1636
Query: 479 RTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDI 538
R QL+ A LR+Q +E+ + + L++ E + ++ E+
Sbjct: 1637 RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEAER-------- 1675
Query: 539 NTAYARLRGIEQAVQSHAVAEEEARKAHQL 568
A R + EQAV+ +AE+E K QL
Sbjct: 1676 -EARRRGKAEEQAVRQRELAEQELEKQRQL 1704
Score = 46.2 bits (108), Expect = 1e-04
Identities = 111/511 (21%), Positives = 191/511 (37%), Gaps = 94/511 (18%)
Query: 166 EESLKTDHPEIGEGKPTPALS---EASSSSIRE-------------------RPPEEVAA 203
EE L+ ++ E + PA EA+ +S+++ R +EV
Sbjct: 1106 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1165
Query: 204 RLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQA------VNAHSNILKA 257
RL Q+ + V++E + + L + +V Q Q Q ++ L A
Sbjct: 1166 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1225
Query: 258 AMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVA 317
+ ++ E+ A A++E+ + ALL EE+E+ +E ++
Sbjct: 1226 WLQDARRRQEQIQAMPLADSQAVREQLRQ----EQALL---EEIERHGEKVEECQRF--- 1275
Query: 318 GAKPHITAAEGKLHNMIVDLDNVVKKVQ----AAQSEAKVVSQYHELVVQARDDFKRELD 373
AK +I A + +L V K Q A+ ++ V E V+Q D +
Sbjct: 1276 -AKQYINAIKD------YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1328
Query: 374 SITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLAL 433
+T T I+ RR+++ R LAEQ+ E
Sbjct: 1329 ELTT------------------LTSQYIKFISETLRRMEEEER-LAEQQRAE-------- 1361
Query: 434 EKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ----LRRQAAAH 489
E+++L E A ALE R +A K + R+A E + R Q R +AA
Sbjct: 1362 ERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1414
Query: 490 TDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDINTAYARLRG 547
+ ++ + Q+L+ E + K + E + R +E++ L + + G
Sbjct: 1415 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1474
Query: 548 IEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAVEA-IKANCS 603
E +Q+ A AEE + Q E L+ ++ S + L S V+A +A
Sbjct: 1475 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1534
Query: 604 DNEFTQAL-TAAIPPESLTRGVYSEETLRAR 633
QAL + E R + E RAR
Sbjct: 1535 KQRALQALEELRLQAEEAERRLRQAEVERAR 1565
Score = 40.0 bits (92), Expect = 0.008
Identities = 73/349 (20%), Positives = 144/349 (41%), Gaps = 47/349 (13%)
Query: 185 LSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTLQAIAAQNA 243
+ + + + R + AARL Q +++ + +LA K L++ ++ T A+
Sbjct: 2277 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2336
Query: 244 AVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAADALLKAKEE 300
Q A + D ++A E+ RT+E ER++ ++ +A+A E
Sbjct: 2337 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAEA-----ER 2388
Query: 301 LEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQSEAKVVSQY 357
L+ + + A+ + A+ AE KLH + V VQ + + +
Sbjct: 2389 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2448
Query: 358 HELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDLADKLSTDD 399
E + +A + +RE + + E +L + + S L++K S
Sbjct: 2449 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2508
Query: 400 LNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHR 456
I +++QL ++ A+Q E+Q ++Q++E++R VA E R
Sbjct: 2509 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLVASMEEARR 2561
Query: 457 SEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 503
+ +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2562 RQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2608
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 65.1 bits (157), Expect = 2e-10
Identities = 116/544 (21%), Positives = 211/544 (38%), Gaps = 66/544 (12%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPE 175
E+ + +Q S L + +G+ A+ A EA + A + V+ E LK E
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123
Query: 176 IGEGKPTPALSEASSSSIRERPPEEVAARLAQQE----KQEQV---KIESLAKSLEDALR 228
+ + A ++A++ +R+ +E AAR AQ E +Q+Q ++E K E LR
Sbjct: 2124 QAQAR---AQAQAAAEKLRKEAEQE-AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179
Query: 229 QTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVD 288
Q A V Q + ++ + N+L + + + + Q R V+
Sbjct: 2180 QKAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-----------RSQVE 2227
Query: 289 EAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQ 348
E ++ EEL K+K+ IE + + + D DN + +Q
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALI-----------------LRDKDNTQRFLQEEA 2270
Query: 349 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHA 407
+ K V++ + A + R L + E L + ++ L +K+ + + L A A
Sbjct: 2271 EKMKQVAEEAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2329
Query: 408 HRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKI 467
+ Q +ELA+++A Q + +Q EE + F ++AE+ R++
Sbjct: 2330 E--LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQL 2376
Query: 468 EEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQF 523
E +A ++R +A A + R Q +E+ + + +L+ QE +Q
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQT 2433
Query: 524 RRLSQEQVDNFTLDINTAYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSM 579
+ ++Q D+ + A A L ++ +Q A + EE + Q L E
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493
Query: 580 KTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQK 639
S + + +E KA + A E R E R R A +
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553
Query: 640 LARR 643
ARR
Sbjct: 2554 EARR 2557
Score = 62.0 bits (149), Expect = 2e-09
Identities = 120/586 (20%), Positives = 225/586 (38%), Gaps = 81/586 (13%)
Query: 111 ISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAA---GDTLSVPAPAVQPEE 167
+ ++ E+ ++++ +L++ + + E AQ + A S Q E
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1594
Query: 168 SLKTDH---PEIGEGKPTPALSEASSSSIRERPPEEV----------------AARLAQQ 208
SL+ +H ++ E A +A + RE E+ A +AQQ
Sbjct: 1595 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 209 EKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK 268
+ Q + E + E R+ QA+ + E+A ++
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------ELAEQE 1693
Query: 269 KSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKPHITA 325
Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752
Query: 326 AEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKG 385
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1753 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL------ 1806
Query: 386 MSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKR 442
++++ A + L+ +D A A R + + + E K +AL++++ E +R
Sbjct: 1807 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENER 1865
Query: 443 AFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQE 501
A +A + R E QA Q + IEE + ++L RQ D LR +V+E
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925
Query: 502 Q--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------YARLR 546
+ LK+ FE+ + K +E EL+ R+ D ++ A R R
Sbjct: 1926 EILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1984
Query: 547 GIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAVEAIK 599
E+ VQ AEEEA + + L VE LK ++ + + L A EA +
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2044
Query: 600 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 645
E A + L + + E+++ + + ARR A
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Score = 60.5 bits (145), Expect = 6e-09
Identities = 93/422 (22%), Positives = 168/422 (39%), Gaps = 68/422 (16%)
Query: 200 EVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAV----------- 248
++ RLAQ K ++E +ED LRQ V + +A + + +A
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 249 ----NAHSNILKAAMDNSEIAGEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKE 299
NA + E A +++ A + R E +++ A +EAA A E
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Query: 300 ELEKMKSVIENAK----------------------KKEVAGAKPHITAAEGKLHNMIVDL 337
E+E++K+ +E A+ K+ A K H A + K + L
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 338 DNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-- 395
+ + EA+ + E +AR +RE +V + A++L
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV----------EEAERLKQ 2119
Query: 396 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----A 451
S ++ A A ++L +E AEQ+A + E+ L +K+A D+ + K A
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKE-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFA 2174
Query: 452 LEHHRSEIQAEQD----RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 507
+ R + Q EQ+ R E D +N + +L+R A T+ R +V+E+
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 508 FE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 566
+ + LS+ + E + R L DN + +++ + + +VA +EA +
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294
Query: 567 QL 568
QL
Sbjct: 2295 QL 2296
Score = 57.0 bits (136), Expect = 6e-08
Identities = 87/390 (22%), Positives = 164/390 (42%), Gaps = 78/390 (20%)
Query: 184 ALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNA 243
A +E + +++R EEV R +Q K S+ + L+ LRQ++ +QA A Q
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEAEIQAKARQAE 1441
Query: 244 AVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 299
A + + +++ ++ +E Q EG L+ R +EA +A+E
Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEEAEAQKRQAQE 1494
Query: 300 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQSEAKVVSQYH 358
E E+++ +++ +++ V+L + VK + +AA+ + + +
Sbjct: 1495 EAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAREKQRALQALE 1539
Query: 359 ELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNREL 418
EL +QA + +R + EV + + A + + +L S A + QL R L
Sbjct: 1540 ELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 419 AEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEM 478
E+ H+ +A +++ E R++ QAE +R EE +E
Sbjct: 1597 QEE------HVAVAQLREEAER---------------RAQQQAEAERAREEAERELE--- 1632
Query: 479 RTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDI 538
R QL+ A LR+Q +E+ + + L++ E + ++ E+
Sbjct: 1633 RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEAER-------- 1671
Query: 539 NTAYARLRGIEQAVQSHAVAEEEARKAHQL 568
A R + EQAV+ +AE+E K QL
Sbjct: 1672 -EARRRGKAEEQAVRQRELAEQELEKQRQL 1700
Score = 46.2 bits (108), Expect = 1e-04
Identities = 111/511 (21%), Positives = 191/511 (37%), Gaps = 94/511 (18%)
Query: 166 EESLKTDHPEIGEGKPTPALS---EASSSSIRE-------------------RPPEEVAA 203
EE L+ ++ E + PA EA+ +S+++ R +EV
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1161
Query: 204 RLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQA------VNAHSNILKA 257
RL Q+ + V++E + + L + +V Q Q Q ++ L A
Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221
Query: 258 AMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVA 317
+ ++ E+ A A++E+ + ALL EE+E+ +E ++
Sbjct: 1222 WLQDARRRQEQIQAMPLADSQAVREQLRQ----EQALL---EEIERHGEKVEECQRF--- 1271
Query: 318 GAKPHITAAEGKLHNMIVDLDNVVKKVQ----AAQSEAKVVSQYHELVVQARDDFKRELD 373
AK +I A + +L V K Q A+ ++ V E V+Q D +
Sbjct: 1272 -AKQYINAIKD------YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1324
Query: 374 SITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLAL 433
+T T I+ RR+++ R LAEQ+ E
Sbjct: 1325 ELTT------------------LTSQYIKFISETLRRMEEEER-LAEQQRAE-------- 1357
Query: 434 EKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ----LRRQAAAH 489
E+++L E A ALE R +A K + R+A E + R Q R +AA
Sbjct: 1358 ERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1410
Query: 490 TDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDINTAYARLRG 547
+ ++ + Q+L+ E + K + E + R +E++ L + + G
Sbjct: 1411 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470
Query: 548 IEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAVEA-IKANCS 603
E +Q+ A AEE + Q E L+ ++ S + L S V+A +A
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1530
Query: 604 DNEFTQAL-TAAIPPESLTRGVYSEETLRAR 633
QAL + E R + E RAR
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Score = 40.0 bits (92), Expect = 0.008
Identities = 73/349 (20%), Positives = 144/349 (41%), Gaps = 47/349 (13%)
Query: 185 LSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTLQAIAAQNA 243
+ + + + R + AARL Q +++ + +LA K L++ ++ T A+
Sbjct: 2273 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332
Query: 244 AVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAADALLKAKEE 300
Q A + D ++A E+ RT+E ER++ ++ +A+A E
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAEA-----ER 2384
Query: 301 LEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQSEAKVVSQY 357
L+ + + A+ + A+ AE KLH + V VQ + + +
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444
Query: 358 HELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDLADKLSTDD 399
E + +A + +RE + + E +L + + S L++K S
Sbjct: 2445 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 400 LNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHR 456
I +++QL ++ A+Q E+Q ++Q++E++R VA E R
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLVASMEEARR 2557
Query: 457 SEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 503
+ +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2558 RQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2604
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 65.1 bits (157), Expect = 2e-10
Identities = 116/544 (21%), Positives = 211/544 (38%), Gaps = 66/544 (12%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPE 175
E+ + +Q S L + +G+ A+ A EA + A + V+ E LK E
Sbjct: 2032 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2091
Query: 176 IGEGKPTPALSEASSSSIRERPPEEVAARLAQQE----KQEQV---KIESLAKSLEDALR 228
+ + A ++A++ +R+ +E AAR AQ E +Q+Q ++E K E LR
Sbjct: 2092 QAQAR---AQAQAAAEKLRKEAEQE-AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2147
Query: 229 QTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVD 288
Q A V Q + ++ + N+L + + + + Q R V+
Sbjct: 2148 QKAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-----------RSQVE 2195
Query: 289 EAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQ 348
E ++ EEL K+K+ IE + + + D DN + +Q
Sbjct: 2196 EELFSVRVQMEELSKLKARIEAENRALI-----------------LRDKDNTQRFLQEEA 2238
Query: 349 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHA 407
+ K V++ + A + R L + E L + ++ L +K+ + + L A A
Sbjct: 2239 EKMKQVAEEAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2297
Query: 408 HRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKI 467
+ Q +ELA+++A Q + +Q EE + F ++AE+ R++
Sbjct: 2298 E--LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQL 2344
Query: 468 EEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQF 523
E +A ++R +A A + R Q +E+ + + +L+ QE +Q
Sbjct: 2345 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQT 2401
Query: 524 RRLSQEQVDNFTLDINTAYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSM 579
+ ++Q D+ + A A L ++ +Q A + EE + Q L E
Sbjct: 2402 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2461
Query: 580 KTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQK 639
S + + +E KA + A E R E R R A +
Sbjct: 2462 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2521
Query: 640 LARR 643
ARR
Sbjct: 2522 EARR 2525
Score = 62.0 bits (149), Expect = 2e-09
Identities = 120/586 (20%), Positives = 225/586 (38%), Gaps = 81/586 (13%)
Query: 111 ISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAA---GDTLSVPAPAVQPEE 167
+ ++ E+ ++++ +L++ + + E AQ + A S Q E
Sbjct: 1503 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1562
Query: 168 SLKTDH---PEIGEGKPTPALSEASSSSIRERPPEEV----------------AARLAQQ 208
SL+ +H ++ E A +A + RE E+ A +AQQ
Sbjct: 1563 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1622
Query: 209 EKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK 268
+ Q + E + E R+ QA+ + E+A ++
Sbjct: 1623 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------ELAEQE 1661
Query: 269 KSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKPHITA 325
Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1662 LEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1720
Query: 326 AEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKG 385
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1721 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL------ 1774
Query: 386 MSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKR 442
++++ A + L+ +D A A R + + + E K +AL++++ E +R
Sbjct: 1775 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENER 1833
Query: 443 AFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQE 501
A +A + R E QA Q + IEE + ++L RQ D LR +V+E
Sbjct: 1834 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1893
Query: 502 Q--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------YARLR 546
+ LK+ FE+ + K +E EL+ R+ D ++ A R R
Sbjct: 1894 EILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1952
Query: 547 GIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAVEAIK 599
E+ VQ AEEEA + + L VE LK ++ + + L A EA +
Sbjct: 1953 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2012
Query: 600 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 645
E A + L + + E+++ + + ARR A
Sbjct: 2013 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2058
Score = 60.5 bits (145), Expect = 6e-09
Identities = 93/422 (22%), Positives = 168/422 (39%), Gaps = 68/422 (16%)
Query: 200 EVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAV----------- 248
++ RLAQ K ++E +ED LRQ V + +A + + +A
Sbjct: 1858 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1917
Query: 249 ----NAHSNILKAAMDNSEIAGEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKE 299
NA + E A +++ A + R E +++ A +EAA A E
Sbjct: 1918 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1977
Query: 300 ELEKMKSVIENAK----------------------KKEVAGAKPHITAAEGKLHNMIVDL 337
E+E++K+ +E A+ K+ A K H A + K + L
Sbjct: 1978 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2037
Query: 338 DNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-- 395
+ + EA+ + E +AR +RE +V + A++L
Sbjct: 2038 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV----------EEAERLKQ 2087
Query: 396 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----A 451
S ++ A A ++L +E AEQ+A + E+ L +K+A D+ + K A
Sbjct: 2088 SAEEQAQARAQAQAAAEKLRKE-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFA 2142
Query: 452 LEHHRSEIQAEQD----RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 507
+ R + Q EQ+ R E D +N + +L+R A T+ R +V+E+
Sbjct: 2143 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2202
Query: 508 FE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 566
+ + LS+ + E + R L DN + +++ + + +VA +EA +
Sbjct: 2203 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2262
Query: 567 QL 568
QL
Sbjct: 2263 QL 2264
Score = 57.0 bits (136), Expect = 6e-08
Identities = 87/390 (22%), Positives = 164/390 (42%), Gaps = 78/390 (20%)
Query: 184 ALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNA 243
A +E + +++R EEV R +Q K S+ + L+ LRQ++ +QA A Q
Sbjct: 1352 AQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEAEIQAKARQAE 1409
Query: 244 AVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 299
A + + +++ ++ +E Q EG L+ R +EA +A+E
Sbjct: 1410 AAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEEAEAQKRQAQE 1462
Query: 300 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQSEAKVVSQYH 358
E E+++ +++ +++ V+L + VK + +AA+ + + +
Sbjct: 1463 EAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAREKQRALQALE 1507
Query: 359 ELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNREL 418
EL +QA + +R + EV + + A + + +L S A + QL R L
Sbjct: 1508 ELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564
Query: 419 AEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEM 478
E+ H+ +A +++ E R++ QAE +R EE +E
Sbjct: 1565 QEE------HVAVAQLREEAER---------------RAQQQAEAERAREEAERELE--- 1600
Query: 479 RTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDI 538
R QL+ A LR+Q +E+ + + L++ E + ++ E+
Sbjct: 1601 RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEAER-------- 1639
Query: 539 NTAYARLRGIEQAVQSHAVAEEEARKAHQL 568
A R + EQAV+ +AE+E K QL
Sbjct: 1640 -EARRRGKAEEQAVRQRELAEQELEKQRQL 1668
Score = 46.2 bits (108), Expect = 1e-04
Identities = 111/511 (21%), Positives = 191/511 (37%), Gaps = 94/511 (18%)
Query: 166 EESLKTDHPEIGEGKPTPALS---EASSSSIRE-------------------RPPEEVAA 203
EE L+ ++ E + PA EA+ +S+++ R +EV
Sbjct: 1070 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1129
Query: 204 RLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQA------VNAHSNILKA 257
RL Q+ + V++E + + L + +V Q Q Q ++ L A
Sbjct: 1130 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1189
Query: 258 AMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVA 317
+ ++ E+ A A++E+ + ALL EE+E+ +E ++
Sbjct: 1190 WLQDARRRQEQIQAMPLADSQAVREQLRQ----EQALL---EEIERHGEKVEECQRF--- 1239
Query: 318 GAKPHITAAEGKLHNMIVDLDNVVKKVQ----AAQSEAKVVSQYHELVVQARDDFKRELD 373
AK +I A + +L V K Q A+ ++ V E V+Q D +
Sbjct: 1240 -AKQYINAIKD------YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1292
Query: 374 SITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLAL 433
+T T I+ RR+++ R LAEQ+ E
Sbjct: 1293 ELTT------------------LTSQYIKFISETLRRMEEEER-LAEQQRAE-------- 1325
Query: 434 EKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ----LRRQAAAH 489
E+++L E A ALE R +A K + R+A E + R Q R +AA
Sbjct: 1326 ERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1378
Query: 490 TDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDINTAYARLRG 547
+ ++ + Q+L+ E + K + E + R +E++ L + + G
Sbjct: 1379 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1438
Query: 548 IEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAVEA-IKANCS 603
E +Q+ A AEE + Q E L+ ++ S + L S V+A +A
Sbjct: 1439 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1498
Query: 604 DNEFTQAL-TAAIPPESLTRGVYSEETLRAR 633
QAL + E R + E RAR
Sbjct: 1499 KQRALQALEELRLQAEEAERRLRQAEVERAR 1529
Score = 40.0 bits (92), Expect = 0.008
Identities = 73/349 (20%), Positives = 144/349 (41%), Gaps = 47/349 (13%)
Query: 185 LSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTLQAIAAQNA 243
+ + + + R + AARL Q +++ + +LA K L++ ++ T A+
Sbjct: 2241 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2300
Query: 244 AVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAADALLKAKEE 300
Q A + D ++A E+ RT+E ER++ ++ +A+A E
Sbjct: 2301 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAEA-----ER 2352
Query: 301 LEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQSEAKVVSQY 357
L+ + + A+ + A+ AE KLH + V VQ + + +
Sbjct: 2353 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2412
Query: 358 HELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDLADKLSTDD 399
E + +A + +RE + + E +L + + S L++K S
Sbjct: 2413 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2472
Query: 400 LNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHR 456
I +++QL ++ A+Q E+Q ++Q++E++R VA E R
Sbjct: 2473 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLVASMEEARR 2525
Query: 457 SEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 503
+ +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2526 RQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2572
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 65.1 bits (157), Expect = 2e-10
Identities = 116/544 (21%), Positives = 211/544 (38%), Gaps = 66/544 (12%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPE 175
E+ + +Q S L + +G+ A+ A EA + A + V+ E LK E
Sbjct: 2201 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2260
Query: 176 IGEGKPTPALSEASSSSIRERPPEEVAARLAQQE----KQEQV---KIESLAKSLEDALR 228
+ + A ++A++ +R+ +E AAR AQ E +Q+Q ++E K E LR
Sbjct: 2261 QAQAR---AQAQAAAEKLRKEAEQE-AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2316
Query: 229 QTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVD 288
Q A V Q + ++ + N+L + + + + Q R V+
Sbjct: 2317 QKAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-----------RSQVE 2364
Query: 289 EAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQ 348
E ++ EEL K+K+ IE + + + D DN + +Q
Sbjct: 2365 EELFSVRVQMEELSKLKARIEAENRALI-----------------LRDKDNTQRFLQEEA 2407
Query: 349 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHA 407
+ K V++ + A + R L + E L + ++ L +K+ + + L A A
Sbjct: 2408 EKMKQVAEEAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2466
Query: 408 HRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKI 467
+ Q +ELA+++A Q + +Q EE + F ++AE+ R++
Sbjct: 2467 E--LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQL 2513
Query: 468 EEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQF 523
E +A ++R +A A + R Q +E+ + + +L+ QE +Q
Sbjct: 2514 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQT 2570
Query: 524 RRLSQEQVDNFTLDINTAYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSM 579
+ ++Q D+ + A A L ++ +Q A + EE + Q L E
Sbjct: 2571 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2630
Query: 580 KTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQK 639
S + + +E KA + A E R E R R A +
Sbjct: 2631 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2690
Query: 640 LARR 643
ARR
Sbjct: 2691 EARR 2694
Score = 62.0 bits (149), Expect = 2e-09
Identities = 120/586 (20%), Positives = 225/586 (38%), Gaps = 81/586 (13%)
Query: 111 ISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAA---GDTLSVPAPAVQPEE 167
+ ++ E+ ++++ +L++ + + E AQ + A S Q E
Sbjct: 1672 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1731
Query: 168 SLKTDH---PEIGEGKPTPALSEASSSSIRERPPEEV----------------AARLAQQ 208
SL+ +H ++ E A +A + RE E+ A +AQQ
Sbjct: 1732 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1791
Query: 209 EKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK 268
+ Q + E + E R+ QA+ + E+A ++
Sbjct: 1792 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------ELAEQE 1830
Query: 269 KSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKPHITA 325
Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1831 LEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1889
Query: 326 AEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKG 385
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1890 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL------ 1943
Query: 386 MSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKR 442
++++ A + L+ +D A A R + + + E K +AL++++ E +R
Sbjct: 1944 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENER 2002
Query: 443 AFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQE 501
A +A + R E QA Q + IEE + ++L RQ D LR +V+E
Sbjct: 2003 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 2062
Query: 502 Q--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------YARLR 546
+ LK+ FE+ + K +E EL+ R+ D ++ A R R
Sbjct: 2063 EILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 2121
Query: 547 GIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAVEAIK 599
E+ VQ AEEEA + + L VE LK ++ + + L A EA +
Sbjct: 2122 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2181
Query: 600 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 645
E A + L + + E+++ + + ARR A
Sbjct: 2182 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2227
Score = 60.5 bits (145), Expect = 6e-09
Identities = 93/422 (22%), Positives = 168/422 (39%), Gaps = 68/422 (16%)
Query: 200 EVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAV----------- 248
++ RLAQ K ++E +ED LRQ V + +A + + +A
Sbjct: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086
Query: 249 ----NAHSNILKAAMDNSEIAGEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKE 299
NA + E A +++ A + R E +++ A +EAA A E
Sbjct: 2087 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2146
Query: 300 ELEKMKSVIENAK----------------------KKEVAGAKPHITAAEGKLHNMIVDL 337
E+E++K+ +E A+ K+ A K H A + K + L
Sbjct: 2147 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2206
Query: 338 DNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-- 395
+ + EA+ + E +AR +RE +V + A++L
Sbjct: 2207 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV----------EEAERLKQ 2256
Query: 396 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----A 451
S ++ A A ++L +E AEQ+A + E+ L +K+A D+ + K A
Sbjct: 2257 SAEEQAQARAQAQAAAEKLRKE-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFA 2311
Query: 452 LEHHRSEIQAEQD----RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 507
+ R + Q EQ+ R E D +N + +L+R A T+ R +V+E+
Sbjct: 2312 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2371
Query: 508 FE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 566
+ + LS+ + E + R L DN + +++ + + +VA +EA +
Sbjct: 2372 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2431
Query: 567 QL 568
QL
Sbjct: 2432 QL 2433
Score = 57.0 bits (136), Expect = 6e-08
Identities = 87/390 (22%), Positives = 164/390 (42%), Gaps = 78/390 (20%)
Query: 184 ALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNA 243
A +E + +++R EEV R +Q K S+ + L+ LRQ++ +QA A Q
Sbjct: 1521 AQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEAEIQAKARQAE 1578
Query: 244 AVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 299
A + + +++ ++ +E Q EG L+ R +EA +A+E
Sbjct: 1579 AAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEEAEAQKRQAQE 1631
Query: 300 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQSEAKVVSQYH 358
E E+++ +++ +++ V+L + VK + +AA+ + + +
Sbjct: 1632 EAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAREKQRALQALE 1676
Query: 359 ELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNREL 418
EL +QA + +R + EV + + A + + +L S A + QL R L
Sbjct: 1677 ELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733
Query: 419 AEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEM 478
E+ H+ +A +++ E R++ QAE +R EE +E
Sbjct: 1734 QEE------HVAVAQLREEAER---------------RAQQQAEAERAREEAERELE--- 1769
Query: 479 RTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDI 538
R QL+ A LR+Q +E+ + + L++ E + ++ E+
Sbjct: 1770 RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEAER-------- 1808
Query: 539 NTAYARLRGIEQAVQSHAVAEEEARKAHQL 568
A R + EQAV+ +AE+E K QL
Sbjct: 1809 -EARRRGKAEEQAVRQRELAEQELEKQRQL 1837
Score = 46.2 bits (108), Expect = 1e-04
Identities = 111/511 (21%), Positives = 191/511 (37%), Gaps = 94/511 (18%)
Query: 166 EESLKTDHPEIGEGKPTPALS---EASSSSIRE-------------------RPPEEVAA 203
EE L+ ++ E + PA EA+ +S+++ R +EV
Sbjct: 1239 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1298
Query: 204 RLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQA------VNAHSNILKA 257
RL Q+ + V++E + + L + +V Q Q Q ++ L A
Sbjct: 1299 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1358
Query: 258 AMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVA 317
+ ++ E+ A A++E+ + ALL EE+E+ +E ++
Sbjct: 1359 WLQDARRRQEQIQAMPLADSQAVREQLRQ----EQALL---EEIERHGEKVEECQRF--- 1408
Query: 318 GAKPHITAAEGKLHNMIVDLDNVVKKVQ----AAQSEAKVVSQYHELVVQARDDFKRELD 373
AK +I A + +L V K Q A+ ++ V E V+Q D +
Sbjct: 1409 -AKQYINAIKD------YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1461
Query: 374 SITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLAL 433
+T T I+ RR+++ R LAEQ+ E
Sbjct: 1462 ELTT------------------LTSQYIKFISETLRRMEEEER-LAEQQRAE-------- 1494
Query: 434 EKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ----LRRQAAAH 489
E+++L E A ALE R +A K + R+A E + R Q R +AA
Sbjct: 1495 ERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1547
Query: 490 TDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDINTAYARLRG 547
+ ++ + Q+L+ E + K + E + R +E++ L + + G
Sbjct: 1548 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1607
Query: 548 IEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAVEA-IKANCS 603
E +Q+ A AEE + Q E L+ ++ S + L S V+A +A
Sbjct: 1608 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1667
Query: 604 DNEFTQAL-TAAIPPESLTRGVYSEETLRAR 633
QAL + E R + E RAR
Sbjct: 1668 KQRALQALEELRLQAEEAERRLRQAEVERAR 1698
Score = 40.0 bits (92), Expect = 0.008
Identities = 73/349 (20%), Positives = 144/349 (41%), Gaps = 47/349 (13%)
Query: 185 LSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTLQAIAAQNA 243
+ + + + R + AARL Q +++ + +LA K L++ ++ T A+
Sbjct: 2410 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2469
Query: 244 AVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAADALLKAKEE 300
Q A + D ++A E+ RT+E ER++ ++ +A+A E
Sbjct: 2470 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAEA-----ER 2521
Query: 301 LEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQSEAKVVSQY 357
L+ + + A+ + A+ AE KLH + V VQ + + +
Sbjct: 2522 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2581
Query: 358 HELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDLADKLSTDD 399
E + +A + +RE + + E +L + + S L++K S
Sbjct: 2582 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2641
Query: 400 LNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHR 456
I +++QL ++ A+Q E+Q ++Q++E++R VA E R
Sbjct: 2642 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLVASMEEARR 2694
Query: 457 SEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 503
+ +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2695 RQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2741
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 65.1 bits (157), Expect = 2e-10
Identities = 116/544 (21%), Positives = 211/544 (38%), Gaps = 66/544 (12%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPE 175
E+ + +Q S L + +G+ A+ A EA + A + V+ E LK E
Sbjct: 2042 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2101
Query: 176 IGEGKPTPALSEASSSSIRERPPEEVAARLAQQE----KQEQV---KIESLAKSLEDALR 228
+ + A ++A++ +R+ +E AAR AQ E +Q+Q ++E K E LR
Sbjct: 2102 QAQAR---AQAQAAAEKLRKEAEQE-AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2157
Query: 229 QTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVD 288
Q A V Q + ++ + N+L + + + + Q R V+
Sbjct: 2158 QKAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-----------RSQVE 2205
Query: 289 EAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQ 348
E ++ EEL K+K+ IE + + + D DN + +Q
Sbjct: 2206 EELFSVRVQMEELSKLKARIEAENRALI-----------------LRDKDNTQRFLQEEA 2248
Query: 349 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHA 407
+ K V++ + A + R L + E L + ++ L +K+ + + L A A
Sbjct: 2249 EKMKQVAEEAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2307
Query: 408 HRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKI 467
+ Q +ELA+++A Q + +Q EE + F ++AE+ R++
Sbjct: 2308 E--LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQL 2354
Query: 468 EEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQF 523
E +A ++R +A A + R Q +E+ + + +L+ QE +Q
Sbjct: 2355 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQT 2411
Query: 524 RRLSQEQVDNFTLDINTAYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSM 579
+ ++Q D+ + A A L ++ +Q A + EE + Q L E
Sbjct: 2412 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2471
Query: 580 KTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQK 639
S + + +E KA + A E R E R R A +
Sbjct: 2472 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2531
Query: 640 LARR 643
ARR
Sbjct: 2532 EARR 2535
Score = 62.0 bits (149), Expect = 2e-09
Identities = 120/586 (20%), Positives = 225/586 (38%), Gaps = 81/586 (13%)
Query: 111 ISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAA---GDTLSVPAPAVQPEE 167
+ ++ E+ ++++ +L++ + + E AQ + A S Q E
Sbjct: 1513 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1572
Query: 168 SLKTDH---PEIGEGKPTPALSEASSSSIRERPPEEV----------------AARLAQQ 208
SL+ +H ++ E A +A + RE E+ A +AQQ
Sbjct: 1573 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1632
Query: 209 EKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK 268
+ Q + E + E R+ QA+ + E+A ++
Sbjct: 1633 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------ELAEQE 1671
Query: 269 KSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKPHITA 325
Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1672 LEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1730
Query: 326 AEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKG 385
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1731 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL------ 1784
Query: 386 MSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKR 442
++++ A + L+ +D A A R + + + E K +AL++++ E +R
Sbjct: 1785 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENER 1843
Query: 443 AFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQE 501
A +A + R E QA Q + IEE + ++L RQ D LR +V+E
Sbjct: 1844 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1903
Query: 502 Q--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------YARLR 546
+ LK+ FE+ + K +E EL+ R+ D ++ A R R
Sbjct: 1904 EILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1962
Query: 547 GIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAVEAIK 599
E+ VQ AEEEA + + L VE LK ++ + + L A EA +
Sbjct: 1963 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2022
Query: 600 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 645
E A + L + + E+++ + + ARR A
Sbjct: 2023 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2068
Score = 60.5 bits (145), Expect = 6e-09
Identities = 93/422 (22%), Positives = 168/422 (39%), Gaps = 68/422 (16%)
Query: 200 EVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAV----------- 248
++ RLAQ K ++E +ED LRQ V + +A + + +A
Sbjct: 1868 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1927
Query: 249 ----NAHSNILKAAMDNSEIAGEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKE 299
NA + E A +++ A + R E +++ A +EAA A E
Sbjct: 1928 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1987
Query: 300 ELEKMKSVIENAK----------------------KKEVAGAKPHITAAEGKLHNMIVDL 337
E+E++K+ +E A+ K+ A K H A + K + L
Sbjct: 1988 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2047
Query: 338 DNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-- 395
+ + EA+ + E +AR +RE +V + A++L
Sbjct: 2048 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV----------EEAERLKQ 2097
Query: 396 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----A 451
S ++ A A ++L +E AEQ+A + E+ L +K+A D+ + K A
Sbjct: 2098 SAEEQAQARAQAQAAAEKLRKE-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFA 2152
Query: 452 LEHHRSEIQAEQD----RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 507
+ R + Q EQ+ R E D +N + +L+R A T+ R +V+E+
Sbjct: 2153 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2212
Query: 508 FE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 566
+ + LS+ + E + R L DN + +++ + + +VA +EA +
Sbjct: 2213 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2272
Query: 567 QL 568
QL
Sbjct: 2273 QL 2274
Score = 57.0 bits (136), Expect = 6e-08
Identities = 87/390 (22%), Positives = 164/390 (42%), Gaps = 78/390 (20%)
Query: 184 ALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNA 243
A +E + +++R EEV R +Q K S+ + L+ LRQ++ +QA A Q
Sbjct: 1362 AQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEAEIQAKARQAE 1419
Query: 244 AVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 299
A + + +++ ++ +E Q EG L+ R +EA +A+E
Sbjct: 1420 AAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEEAEAQKRQAQE 1472
Query: 300 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQSEAKVVSQYH 358
E E+++ +++ +++ V+L + VK + +AA+ + + +
Sbjct: 1473 EAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAREKQRALQALE 1517
Query: 359 ELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNREL 418
EL +QA + +R + EV + + A + + +L S A + QL R L
Sbjct: 1518 ELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574
Query: 419 AEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEM 478
E+ H+ +A +++ E R++ QAE +R EE +E
Sbjct: 1575 QEE------HVAVAQLREEAER---------------RAQQQAEAERAREEAERELE--- 1610
Query: 479 RTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDI 538
R QL+ A LR+Q +E+ + + L++ E + ++ E+
Sbjct: 1611 RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEAER-------- 1649
Query: 539 NTAYARLRGIEQAVQSHAVAEEEARKAHQL 568
A R + EQAV+ +AE+E K QL
Sbjct: 1650 -EARRRGKAEEQAVRQRELAEQELEKQRQL 1678
Score = 46.2 bits (108), Expect = 1e-04
Identities = 111/511 (21%), Positives = 191/511 (37%), Gaps = 94/511 (18%)
Query: 166 EESLKTDHPEIGEGKPTPALS---EASSSSIRE-------------------RPPEEVAA 203
EE L+ ++ E + PA EA+ +S+++ R +EV
Sbjct: 1080 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1139
Query: 204 RLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQA------VNAHSNILKA 257
RL Q+ + V++E + + L + +V Q Q Q ++ L A
Sbjct: 1140 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1199
Query: 258 AMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVA 317
+ ++ E+ A A++E+ + ALL EE+E+ +E ++
Sbjct: 1200 WLQDARRRQEQIQAMPLADSQAVREQLRQ----EQALL---EEIERHGEKVEECQRF--- 1249
Query: 318 GAKPHITAAEGKLHNMIVDLDNVVKKVQ----AAQSEAKVVSQYHELVVQARDDFKRELD 373
AK +I A + +L V K Q A+ ++ V E V+Q D +
Sbjct: 1250 -AKQYINAIKD------YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1302
Query: 374 SITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLAL 433
+T T I+ RR+++ R LAEQ+ E
Sbjct: 1303 ELTT------------------LTSQYIKFISETLRRMEEEER-LAEQQRAE-------- 1335
Query: 434 EKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ----LRRQAAAH 489
E+++L E A ALE R +A K + R+A E + R Q R +AA
Sbjct: 1336 ERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1388
Query: 490 TDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDINTAYARLRG 547
+ ++ + Q+L+ E + K + E + R +E++ L + + G
Sbjct: 1389 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1448
Query: 548 IEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAVEA-IKANCS 603
E +Q+ A AEE + Q E L+ ++ S + L S V+A +A
Sbjct: 1449 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1508
Query: 604 DNEFTQAL-TAAIPPESLTRGVYSEETLRAR 633
QAL + E R + E RAR
Sbjct: 1509 KQRALQALEELRLQAEEAERRLRQAEVERAR 1539
Score = 40.0 bits (92), Expect = 0.008
Identities = 73/349 (20%), Positives = 144/349 (41%), Gaps = 47/349 (13%)
Query: 185 LSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTLQAIAAQNA 243
+ + + + R + AARL Q +++ + +LA K L++ ++ T A+
Sbjct: 2251 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2310
Query: 244 AVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAADALLKAKEE 300
Q A + D ++A E+ RT+E ER++ ++ +A+A E
Sbjct: 2311 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAEA-----ER 2362
Query: 301 LEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQSEAKVVSQY 357
L+ + + A+ + A+ AE KLH + V VQ + + +
Sbjct: 2363 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2422
Query: 358 HELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDLADKLSTDD 399
E + +A + +RE + + E +L + + S L++K S
Sbjct: 2423 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2482
Query: 400 LNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHR 456
I +++QL ++ A+Q E+Q ++Q++E++R VA E R
Sbjct: 2483 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLVASMEEARR 2535
Query: 457 SEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 503
+ +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2536 RQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2582
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 65.1 bits (157), Expect = 2e-10
Identities = 116/544 (21%), Positives = 211/544 (38%), Gaps = 66/544 (12%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPE 175
E+ + +Q S L + +G+ A+ A EA + A + V+ E LK E
Sbjct: 2050 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2109
Query: 176 IGEGKPTPALSEASSSSIRERPPEEVAARLAQQE----KQEQV---KIESLAKSLEDALR 228
+ + A ++A++ +R+ +E AAR AQ E +Q+Q ++E K E LR
Sbjct: 2110 QAQAR---AQAQAAAEKLRKEAEQE-AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2165
Query: 229 QTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVD 288
Q A V Q + ++ + N+L + + + + Q R V+
Sbjct: 2166 QKAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-----------RSQVE 2213
Query: 289 EAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQ 348
E ++ EEL K+K+ IE + + + D DN + +Q
Sbjct: 2214 EELFSVRVQMEELSKLKARIEAENRALI-----------------LRDKDNTQRFLQEEA 2256
Query: 349 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHA 407
+ K V++ + A + R L + E L + ++ L +K+ + + L A A
Sbjct: 2257 EKMKQVAEEAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2315
Query: 408 HRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKI 467
+ Q +ELA+++A Q + +Q EE + F ++AE+ R++
Sbjct: 2316 E--LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQL 2362
Query: 468 EEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQF 523
E +A ++R +A A + R Q +E+ + + +L+ QE +Q
Sbjct: 2363 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQT 2419
Query: 524 RRLSQEQVDNFTLDINTAYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSM 579
+ ++Q D+ + A A L ++ +Q A + EE + Q L E
Sbjct: 2420 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2479
Query: 580 KTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQK 639
S + + +E KA + A E R E R R A +
Sbjct: 2480 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2539
Query: 640 LARR 643
ARR
Sbjct: 2540 EARR 2543
Score = 62.0 bits (149), Expect = 2e-09
Identities = 120/586 (20%), Positives = 225/586 (38%), Gaps = 81/586 (13%)
Query: 111 ISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAA---GDTLSVPAPAVQPEE 167
+ ++ E+ ++++ +L++ + + E AQ + A S Q E
Sbjct: 1521 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1580
Query: 168 SLKTDH---PEIGEGKPTPALSEASSSSIRERPPEEV----------------AARLAQQ 208
SL+ +H ++ E A +A + RE E+ A +AQQ
Sbjct: 1581 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1640
Query: 209 EKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK 268
+ Q + E + E R+ QA+ + E+A ++
Sbjct: 1641 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------ELAEQE 1679
Query: 269 KSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKPHITA 325
Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1680 LEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1738
Query: 326 AEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKG 385
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1739 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL------ 1792
Query: 386 MSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKR 442
++++ A + L+ +D A A R + + + E K +AL++++ E +R
Sbjct: 1793 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENER 1851
Query: 443 AFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQE 501
A +A + R E QA Q + IEE + ++L RQ D LR +V+E
Sbjct: 1852 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1911
Query: 502 Q--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------YARLR 546
+ LK+ FE+ + K +E EL+ R+ D ++ A R R
Sbjct: 1912 EILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1970
Query: 547 GIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAVEAIK 599
E+ VQ AEEEA + + L VE LK ++ + + L A EA +
Sbjct: 1971 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2030
Query: 600 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 645
E A + L + + E+++ + + ARR A
Sbjct: 2031 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2076
Score = 60.5 bits (145), Expect = 6e-09
Identities = 93/422 (22%), Positives = 168/422 (39%), Gaps = 68/422 (16%)
Query: 200 EVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAV----------- 248
++ RLAQ K ++E +ED LRQ V + +A + + +A
Sbjct: 1876 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1935
Query: 249 ----NAHSNILKAAMDNSEIAGEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKE 299
NA + E A +++ A + R E +++ A +EAA A E
Sbjct: 1936 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1995
Query: 300 ELEKMKSVIENAK----------------------KKEVAGAKPHITAAEGKLHNMIVDL 337
E+E++K+ +E A+ K+ A K H A + K + L
Sbjct: 1996 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2055
Query: 338 DNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-- 395
+ + EA+ + E +AR +RE +V + A++L
Sbjct: 2056 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV----------EEAERLKQ 2105
Query: 396 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----A 451
S ++ A A ++L +E AEQ+A + E+ L +K+A D+ + K A
Sbjct: 2106 SAEEQAQARAQAQAAAEKLRKE-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFA 2160
Query: 452 LEHHRSEIQAEQD----RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 507
+ R + Q EQ+ R E D +N + +L+R A T+ R +V+E+
Sbjct: 2161 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2220
Query: 508 FE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 566
+ + LS+ + E + R L DN + +++ + + +VA +EA +
Sbjct: 2221 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2280
Query: 567 QL 568
QL
Sbjct: 2281 QL 2282
Score = 57.0 bits (136), Expect = 6e-08
Identities = 87/390 (22%), Positives = 164/390 (42%), Gaps = 78/390 (20%)
Query: 184 ALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNA 243
A +E + +++R EEV R +Q K S+ + L+ LRQ++ +QA A Q
Sbjct: 1370 AQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEAEIQAKARQAE 1427
Query: 244 AVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 299
A + + +++ ++ +E Q EG L+ R +EA +A+E
Sbjct: 1428 AAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEEAEAQKRQAQE 1480
Query: 300 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQSEAKVVSQYH 358
E E+++ +++ +++ V+L + VK + +AA+ + + +
Sbjct: 1481 EAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAREKQRALQALE 1525
Query: 359 ELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNREL 418
EL +QA + +R + EV + + A + + +L S A + QL R L
Sbjct: 1526 ELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1582
Query: 419 AEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEM 478
E+ H+ +A +++ E R++ QAE +R EE +E
Sbjct: 1583 QEE------HVAVAQLREEAER---------------RAQQQAEAERAREEAERELE--- 1618
Query: 479 RTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDI 538
R QL+ A LR+Q +E+ + + L++ E + ++ E+
Sbjct: 1619 RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEAER-------- 1657
Query: 539 NTAYARLRGIEQAVQSHAVAEEEARKAHQL 568
A R + EQAV+ +AE+E K QL
Sbjct: 1658 -EARRRGKAEEQAVRQRELAEQELEKQRQL 1686
Score = 46.2 bits (108), Expect = 1e-04
Identities = 111/511 (21%), Positives = 191/511 (37%), Gaps = 94/511 (18%)
Query: 166 EESLKTDHPEIGEGKPTPALS---EASSSSIRE-------------------RPPEEVAA 203
EE L+ ++ E + PA EA+ +S+++ R +EV
Sbjct: 1088 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1147
Query: 204 RLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQA------VNAHSNILKA 257
RL Q+ + V++E + + L + +V Q Q Q ++ L A
Sbjct: 1148 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1207
Query: 258 AMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVA 317
+ ++ E+ A A++E+ + ALL EE+E+ +E ++
Sbjct: 1208 WLQDARRRQEQIQAMPLADSQAVREQLRQ----EQALL---EEIERHGEKVEECQRF--- 1257
Query: 318 GAKPHITAAEGKLHNMIVDLDNVVKKVQ----AAQSEAKVVSQYHELVVQARDDFKRELD 373
AK +I A + +L V K Q A+ ++ V E V+Q D +
Sbjct: 1258 -AKQYINAIKD------YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1310
Query: 374 SITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLAL 433
+T T I+ RR+++ R LAEQ+ E
Sbjct: 1311 ELTT------------------LTSQYIKFISETLRRMEEEER-LAEQQRAE-------- 1343
Query: 434 EKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ----LRRQAAAH 489
E+++L E A ALE R +A K + R+A E + R Q R +AA
Sbjct: 1344 ERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1396
Query: 490 TDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDINTAYARLRG 547
+ ++ + Q+L+ E + K + E + R +E++ L + + G
Sbjct: 1397 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1456
Query: 548 IEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAVEA-IKANCS 603
E +Q+ A AEE + Q E L+ ++ S + L S V+A +A
Sbjct: 1457 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1516
Query: 604 DNEFTQAL-TAAIPPESLTRGVYSEETLRAR 633
QAL + E R + E RAR
Sbjct: 1517 KQRALQALEELRLQAEEAERRLRQAEVERAR 1547
Score = 40.0 bits (92), Expect = 0.008
Identities = 73/349 (20%), Positives = 144/349 (41%), Gaps = 47/349 (13%)
Query: 185 LSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTLQAIAAQNA 243
+ + + + R + AARL Q +++ + +LA K L++ ++ T A+
Sbjct: 2259 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2318
Query: 244 AVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAADALLKAKEE 300
Q A + D ++A E+ RT+E ER++ ++ +A+A E
Sbjct: 2319 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAEA-----ER 2370
Query: 301 LEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQSEAKVVSQY 357
L+ + + A+ + A+ AE KLH + V VQ + + +
Sbjct: 2371 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2430
Query: 358 HELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDLADKLSTDD 399
E + +A + +RE + + E +L + + S L++K S
Sbjct: 2431 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2490
Query: 400 LNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHR 456
I +++QL ++ A+Q E+Q ++Q++E++R VA E R
Sbjct: 2491 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLVASMEEARR 2543
Query: 457 SEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 503
+ +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2544 RQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2590
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 65.1 bits (157), Expect = 2e-10
Identities = 116/544 (21%), Positives = 211/544 (38%), Gaps = 66/544 (12%)
Query: 116 EVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPE 175
E+ + +Q S L + +G+ A+ A EA + A + V+ E LK E
Sbjct: 2091 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2150
Query: 176 IGEGKPTPALSEASSSSIRERPPEEVAARLAQQE----KQEQV---KIESLAKSLEDALR 228
+ + A ++A++ +R+ +E AAR AQ E +Q+Q ++E K E LR
Sbjct: 2151 QAQAR---AQAQAAAEKLRKEAEQE-AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2206
Query: 229 QTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVD 288
Q A V Q + ++ + N+L + + + + Q R V+
Sbjct: 2207 QKAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-----------RSQVE 2254
Query: 289 EAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQ 348
E ++ EEL K+K+ IE + + + D DN + +Q
Sbjct: 2255 EELFSVRVQMEELSKLKARIEAENRALI-----------------LRDKDNTQRFLQEEA 2297
Query: 349 SEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-STDDLNSLIAHA 407
+ K V++ + A + R L + E L + ++ L +K+ + + L A A
Sbjct: 2298 EKMKQVAEEAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2356
Query: 408 HRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKI 467
+ Q +ELA+++A Q + +Q EE + F ++AE+ R++
Sbjct: 2357 E--LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT-----------LEAERQRQL 2403
Query: 468 EEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE----LQF 523
E +A ++R +A A + R Q +E+ + + +L+ QE +Q
Sbjct: 2404 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQT 2460
Query: 524 RRLSQEQVDNFTLDINTAYARLRGIEQAVQSHA----VAEEEARKAHQLWLSVEALKYSM 579
+ ++Q D+ + A A L ++ +Q A + EE + Q L E
Sbjct: 2461 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2520
Query: 580 KTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQK 639
S + + +E KA + A E R E R R A +
Sbjct: 2521 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2580
Query: 640 LARR 643
ARR
Sbjct: 2581 EARR 2584
Score = 62.0 bits (149), Expect = 2e-09
Identities = 120/586 (20%), Positives = 225/586 (38%), Gaps = 81/586 (13%)
Query: 111 ISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAA---GDTLSVPAPAVQPEE 167
+ ++ E+ ++++ +L++ + + E AQ + A S Q E
Sbjct: 1562 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1621
Query: 168 SLKTDH---PEIGEGKPTPALSEASSSSIRERPPEEV----------------AARLAQQ 208
SL+ +H ++ E A +A + RE E+ A +AQQ
Sbjct: 1622 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1681
Query: 209 EKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK 268
+ Q + E + E R+ QA+ + E+A ++
Sbjct: 1682 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR---------------------ELAEQE 1720
Query: 269 KSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIEN---AKKKEVAGAKPHITA 325
Q + EG ++R A E L E+ E+ + ++E ++E A A
Sbjct: 1721 LEKQRQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1779
Query: 326 AEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKG 385
E +L + +++ ++ A+ E++ S+ + ++A REL +
Sbjct: 1780 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL------ 1833
Query: 386 MSVSDLADK---LSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKR 442
++++ A + L+ +D A A R + + + E K +AL++++ E +R
Sbjct: 1834 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENER 1892
Query: 443 AFDSAVAKALEHHRSEIQAEQDR-KIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQE 501
A +A + R E QA Q + IEE + ++L RQ D LR +V+E
Sbjct: 1893 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1952
Query: 502 Q--ELKSEFEQNLSEKLSEQELQFRRLSQEQVDNF----TLDINTA---------YARLR 546
+ LK+ FE+ + K +E EL+ R+ D ++ A R R
Sbjct: 1953 EILALKASFEKAAAGK-AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 2011
Query: 547 GIEQAVQSHAVAEEEARKAHQLWL-SVEALKYS------MKTSSAETPTIPLGSAVEAIK 599
E+ VQ AEEEA + + L VE LK ++ + + L A EA +
Sbjct: 2012 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2071
Query: 600 ANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 645
E A + L + + E+++ + + ARR A
Sbjct: 2072 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2117
Score = 60.5 bits (145), Expect = 6e-09
Identities = 93/422 (22%), Positives = 168/422 (39%), Gaps = 68/422 (16%)
Query: 200 EVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAV----------- 248
++ RLAQ K ++E +ED LRQ V + +A + + +A
Sbjct: 1917 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1976
Query: 249 ----NAHSNILKAAMDNSEIAGEKKSA-----QWRTVEGALKERRKAVDEAADALLKAKE 299
NA + E A +++ A + R E +++ A +EAA A E
Sbjct: 1977 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2036
Query: 300 ELEKMKSVIENAK----------------------KKEVAGAKPHITAAEGKLHNMIVDL 337
E+E++K+ +E A+ K+ A K H A + K + L
Sbjct: 2037 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2096
Query: 338 DNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKL-- 395
+ + EA+ + E +AR +RE +V + A++L
Sbjct: 2097 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV----------EEAERLKQ 2146
Query: 396 STDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAK----A 451
S ++ A A ++L +E AEQ+A + E+ L +K+A D+ + K A
Sbjct: 2147 SAEEQAQARAQAQAAAEKLRKE-AEQEAARRAQ----AEQAALRQKQAADAEMEKHKKFA 2201
Query: 452 LEHHRSEIQAEQD----RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 507
+ R + Q EQ+ R E D +N + +L+R A T+ R +V+E+
Sbjct: 2202 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2261
Query: 508 FE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 566
+ + LS+ + E + R L DN + +++ + + +VA +EA +
Sbjct: 2262 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2321
Query: 567 QL 568
QL
Sbjct: 2322 QL 2323
Score = 57.0 bits (136), Expect = 6e-08
Identities = 87/390 (22%), Positives = 164/390 (42%), Gaps = 78/390 (20%)
Query: 184 ALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNA 243
A +E + +++R EEV R +Q K S+ + L+ LRQ++ +QA A Q
Sbjct: 1411 AQAEREAKELQQRMQEEVVRREEAAVDAQQQK-RSIQEELQQ-LRQSSEAEIQAKARQAE 1468
Query: 244 AVQA----VNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKE 299
A + + +++ ++ +E Q EG L+ R +EA +A+E
Sbjct: 1469 AAERSRLRIEEEIRVVRLQLEATE-------RQRGGAEGELQALRARAEEAEAQKRQAQE 1521
Query: 300 ELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVK-KVQAAQSEAKVVSQYH 358
E E+++ +++ +++ V+L + VK + +AA+ + + +
Sbjct: 1522 EAERLRRQVQDESQRK---------------RQAEVELASRVKAEAEAAREKQRALQALE 1566
Query: 359 ELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNREL 418
EL +QA + +R + EV + + A + + +L S A + QL R L
Sbjct: 1567 ELRLQAEEAERRLRQA---EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1623
Query: 419 AEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEM 478
E+ H+ +A +++ E R++ QAE +R EE +E
Sbjct: 1624 QEE------HVAVAQLREEAER---------------RAQQQAEAERAREEAERELE--- 1659
Query: 479 RTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDI 538
R QL+ A LR+Q +E+ + + L++ E + ++ E+
Sbjct: 1660 RWQLKANEALR-------LRLQAEEVAQQ------KSLAQAEAEKQKEEAER-------- 1698
Query: 539 NTAYARLRGIEQAVQSHAVAEEEARKAHQL 568
A R + EQAV+ +AE+E K QL
Sbjct: 1699 -EARRRGKAEEQAVRQRELAEQELEKQRQL 1727
Score = 46.2 bits (108), Expect = 1e-04
Identities = 111/511 (21%), Positives = 191/511 (37%), Gaps = 94/511 (18%)
Query: 166 EESLKTDHPEIGEGKPTPALS---EASSSSIRE-------------------RPPEEVAA 203
EE L+ ++ E + PA EA+ +S+++ R +EV
Sbjct: 1129 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1188
Query: 204 RLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQA------VNAHSNILKA 257
RL Q+ + V++E + + L + +V Q Q Q ++ L A
Sbjct: 1189 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1248
Query: 258 AMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVA 317
+ ++ E+ A A++E+ + ALL EE+E+ +E ++
Sbjct: 1249 WLQDARRRQEQIQAMPLADSQAVREQLRQ----EQALL---EEIERHGEKVEECQRF--- 1298
Query: 318 GAKPHITAAEGKLHNMIVDLDNVVKKVQ----AAQSEAKVVSQYHELVVQARDDFKRELD 373
AK +I A + +L V K Q A+ ++ V E V+Q D +
Sbjct: 1299 -AKQYINAIKD------YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1351
Query: 374 SITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLAL 433
+T T I+ RR+++ R LAEQ+ E
Sbjct: 1352 ELTT------------------LTSQYIKFISETLRRMEEEER-LAEQQRAE-------- 1384
Query: 434 EKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQ----LRRQAAAH 489
E+++L E A ALE R +A K + R+A E + R Q R +AA
Sbjct: 1385 ERERLAEVEA-------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1437
Query: 490 TDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL--QFRRLSQEQVDNFTLDINTAYARLRG 547
+ ++ + Q+L+ E + K + E + R +E++ L + + G
Sbjct: 1438 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1497
Query: 548 IEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSS--AETPTIPLGSAVEA-IKANCS 603
E +Q+ A AEE + Q E L+ ++ S + L S V+A +A
Sbjct: 1498 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1557
Query: 604 DNEFTQAL-TAAIPPESLTRGVYSEETLRAR 633
QAL + E R + E RAR
Sbjct: 1558 KQRALQALEELRLQAEEAERRLRQAEVERAR 1588
Score = 40.0 bits (92), Expect = 0.008
Identities = 73/349 (20%), Positives = 144/349 (41%), Gaps = 47/349 (13%)
Query: 185 LSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA-KSLEDALRQTASVTLQAIAAQNA 243
+ + + + R + AARL Q +++ + +LA K L++ ++ T A+
Sbjct: 2300 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2359
Query: 244 AVQAVNAHSNILKAAMDNSEIA---GEKKSAQWRTVEGALKERRKAVDEAADALLKAKEE 300
Q A + D ++A E+ RT+E ER++ ++ +A+A E
Sbjct: 2360 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA---ERQRQLEMSAEA-----ER 2411
Query: 301 LEKMKSVIENAKKKEVAGAKPHITAAEG---KLHNMIVDLDNVVKKVQAAQSEAKVVSQY 357
L+ + + A+ + A+ AE KLH + V VQ + + +
Sbjct: 2412 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2471
Query: 358 HELVVQARDDFKRELDSITPE------------------VLPGWKGMSVSDLADKLSTDD 399
E + +A + +RE + + E +L + + S L++K S
Sbjct: 2472 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2531
Query: 400 LNSLIAHAHRRIDQLNRE---LAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHR 456
I +++QL ++ A+Q E+Q ++Q++E++R VA E R
Sbjct: 2532 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-----QQQQMEQER--QRLVASMEEARR 2584
Query: 457 SEIQAEQD--RKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQE 503
+ +AE+ RK EE++ + R Q A LR+ L++ E++
Sbjct: 2585 RQHEAEEGVRRKQEELQQL--EQQRRQQEELLAEENQRLREQLQLLEEQ 2631
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 64.7 bits (156), Expect = 3e-10
Identities = 98/486 (20%), Positives = 202/486 (41%), Gaps = 61/486 (12%)
Query: 111 ISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLK 170
+ ++E +KES +LQ + + AS + + + + L + E K
Sbjct: 145 VKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTK 204
Query: 171 TDHP-EIGEGKPTPALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQ 229
TD +G K L + E EEV+ RL +Q + E L K +ED L +
Sbjct: 205 TDELLALGREKGNEILELKCNL---ENKKEEVS-RLEEQMNGLKTSNEHLQKHVEDLLTK 260
Query: 230 TASVTLQAIAAQNAAVQAVNAH---SNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKA 286
Q + + +NAH SN+ K+A D+SE + + + LKE +A
Sbjct: 261 LKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEA 320
Query: 287 VDEAADALLKAKEELEKM-KSVIENAKK--KEVAGAKPHITAAEGKLHNMIVDLDNVVKK 343
D LL+ ++ ++M K ++E + KE+ A ++A + K I+ + +
Sbjct: 321 NKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRK--GAILSEEELAAM 378
Query: 344 VQAAQSEAKVV------SQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLST 397
A + AK+V ++ + V+ +D + + L +K
Sbjct: 379 SPTAAAVAKIVKPGMKLTELYNAYVETQDQ------------------LLLEKLENKRIN 420
Query: 398 DDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALE-KQKLEEKRAFDSAVAKALEHHR 456
L+ ++ + L R+ E + +K +L+++ +Q ++E + KA + +
Sbjct: 421 KYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NKQ 478
Query: 457 SEIQAEQDRKIE-EVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEK 515
S + +R++E +V+D + ++R L A +H+ ++++E+ S + SE
Sbjct: 479 SSVLERDNRRMEIQVKD-LSQQIRVLLMELEEARGNHV-----IRDEEVSSADISSSSEV 532
Query: 516 LSEQELQFRRLSQEQVDNFTL--------------DINTAYARLRGIEQAVQSHAVAEEE 561
+S+ + +R + + Q N L + T +++ ++ ++S E+
Sbjct: 533 ISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQ 592
Query: 562 ARKAHQ 567
RK+ Q
Sbjct: 593 LRKSRQ 598
Score = 53.5 bits (127), Expect = 7e-07
Identities = 86/399 (21%), Positives = 167/399 (41%), Gaps = 54/399 (13%)
Query: 194 RERPPEEVAA----RLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVN 249
RER +E + L + + ++E L KS + ++ S+ Q + Q
Sbjct: 564 REREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTG 623
Query: 250 AHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIE 309
+ +++D+ +A K T + V E+ +A+ +AK L++++ + E
Sbjct: 624 VAIPLHASSLDDVSLASTPKRPS--TSQTVSTPAPVPVIESTEAI-EAKAALKQLQEIFE 680
Query: 310 NAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFK 369
N KK++ K E KL + DL + K+ ++ S+ +E++ + ++
Sbjct: 681 NYKKEKAENEKIQNEQLE-KLQEQVTDLRSQNTKI---STQLDFASKRYEMLQDNVEGYR 736
Query: 370 RELDSITPEVLPGWKGMSVSDLADKLSTDDL---NSLIAHAHRRIDQLNRE--------- 417
RE+ S+ + T DL N +A A R + L +E
Sbjct: 737 REITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEV 796
Query: 418 ---------LAEQKA-----TEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQ 463
LAEQ+ T Q I LE+ + E K+ S + K LEH S ++ +
Sbjct: 797 RLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEK-LEHEISHLKKKL 855
Query: 464 DRKIEEVRDAMENEMRTQL---RRQAAAHTD-HL--RDVLRVQEQELKSEFEQNLSEKLS 517
+ ++E+ R + + QL +RQ T+ HL +++L+ ++E+ + L + LS
Sbjct: 856 ENEVEQ-RHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIAT-----LKQHLS 909
Query: 518 EQELQFRRLSQEQV----DNFTLDINTAYARLRGIEQAV 552
E+Q S ++ + D++ ++LR E+ V
Sbjct: 910 NMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQV 948
Score = 52.0 bits (123), Expect = 2e-06
Identities = 97/456 (21%), Positives = 181/456 (39%), Gaps = 66/456 (14%)
Query: 206 AQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIA 265
A+++ QEQ KI A++ + L AA A+QA + + + + E
Sbjct: 1064 ARRDCQEQAKIAVEAQNKYER-------ELMLHAADVEALQAAKEQVSKMASVRQHLEET 1116
Query: 266 GEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSV----IENAKKKEVAGAKP 321
+K +Q + + +ER + + + + E+LEK + IE K VA K
Sbjct: 1117 TQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKE 1176
Query: 322 HI-------TAAEGKLHNMIVDLDNVVK--------KVQAAQSEAKVVSQYHELVVQARD 366
+ + EGK I+++ ++ + + AQ E+ Q EL+ +
Sbjct: 1177 GVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQ 1236
Query: 367 DFKRELDSITPEVLPGWKGMSV-SDLADKLSTDDL----NSLIAHAHRRIDQ-LNRELAE 420
+ + L++ +V K M+ +L K T ++ N ++ R++Q L + A+
Sbjct: 1237 ELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAK 1296
Query: 421 QKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRT 480
+ E + L +L EK A K LE +A + + +D E R
Sbjct: 1297 VRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYR- 1355
Query: 481 QLRRQAAAHTDHLRDVLRVQEQELKSEF---------EQNLSEKLSEQELQFR---RLSQ 528
+L + HT ++ L + LK+E QNL + L E + R Q
Sbjct: 1356 KLLSEKEVHTKRIQQ-LTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQ 1414
Query: 529 EQVDNFTLDI-----------------NTAYARLRGIEQAV-QSHAVAEEEARKAHQLWL 570
+ +D +DI T Y L+ + V ++ A + + ++ H
Sbjct: 1415 KDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQ 1474
Query: 571 SVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNE 606
++ LK ++ + AET + L S VE ++ S+ E
Sbjct: 1475 EMQELKETL--NQAETKSKSLESQVENLQKTLSEKE 1508
Score = 47.0 bits (110), Expect = 7e-05
Identities = 120/575 (20%), Positives = 227/575 (39%), Gaps = 101/575 (17%)
Query: 66 KWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKESKQPA 125
K + F+ +EK + +K + + + ++ + +SSV ++E+ Q A
Sbjct: 995 KESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRA 1054
Query: 126 SQL----QKQKGDTPASATAPTEAA-----QIISAAGDTLSVPAPAVQPEESLKT-DHPE 175
S Q+ + D A EA +++ A D ++ A Q + H E
Sbjct: 1055 STALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLE 1114
Query: 176 IGEGKPTPALSEASSS-SIRERP-PEEVA---ARLAQQEKQEQV---KIESLAKSLEDAL 227
K L E +S RER +EV+ R EKQ ++ +IE L+ + ++
Sbjct: 1115 ETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASV 1174
Query: 228 RQTASVTLQAIAAQNAAVQA--------VNAHSNILKAAMDNSEIAG-------EKKSAQ 272
++ L ++ Q + I + + +++ E +
Sbjct: 1175 KEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERE 1234
Query: 273 WRTVEGALKERRKAVDEAADALLKAKEELEK---MKSVIENAK--KKEVAGAKPHITAAE 327
+ ++ +L R+ V A + + +E ++K M V+E K ++E + + +
Sbjct: 1235 LQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQ 1294
Query: 328 GKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMS 387
K+ + +D+ +++ A SE + Q + +++ +D KR WK +
Sbjct: 1295 AKVRKLELDI-LPLQEANAELSEKSGMLQAEKKLLE--EDVKR------------WKARN 1339
Query: 388 ---VSDLADKLSTDDLNSLIAHAH---RRIDQLNRELAEQKA---------TEKQHITLA 432
VS D T++ L++ +RI QL E+ KA T Q++ +
Sbjct: 1340 QHLVSQQKDP-DTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQS 1398
Query: 433 LEKQKLEEKRAFDSAVAKALEHHRSEIQAE-----QDRKIEEVRDAMENEMRTQ----LR 483
L K+ L + R + K L+ +IQ + Q +KI E++ Q +
Sbjct: 1399 L-KEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVME 1457
Query: 484 RQAAAHTDHLRDVLRVQE-QELKSEFEQ-------------NLSEKLSEQELQFRRLSQE 529
A + DH + VQE QELK Q NL + LSE+E + R L ++
Sbjct: 1458 TSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQ 1517
Query: 530 QVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARK 564
T+ + + +RLR Q +Q EE+ R+
Sbjct: 1518 -----TVQLQSELSRLR---QDLQDRTTQEEQLRQ 1544
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 60.5 bits (145), Expect = 6e-09
Identities = 115/527 (21%), Positives = 215/527 (40%), Gaps = 91/527 (17%)
Query: 114 VSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPE----ESL 169
+S ++E + SQL + K A E + + + A A+Q + L
Sbjct: 1288 LSRQLEEKESIVSQLSRSK---QAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLL 1344
Query: 170 KTDHPEIGEGKPT--PALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDAL 227
+ + E EGK ALS+A+S + R E A +E +E K LA+ L+D+
Sbjct: 1345 REQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK--KLAQRLQDSE 1402
Query: 228 RQTASV---------TLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRT--- 275
Q +V T Q + + + +N L AA+D + +K A+W+T
Sbjct: 1403 EQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCE 1462
Query: 276 -----VEGALKERR----------KAVDEAADALLKAKEELEKM--------KSVIENAK 312
+E +LKE R A +EA D L K E + + + + EN K
Sbjct: 1463 ESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGK 1522
Query: 313 --------KKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAK-----VVSQYHE 359
+K++ K I A + + + + ++Q ++ K +++ E
Sbjct: 1523 TIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDE 1582
Query: 360 LVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSL---IAHAHRRIDQLNR 416
+ Q + +++R ++++ + + + + K DLN + ++HA+R+ + +
Sbjct: 1583 EIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLK 1642
Query: 417 ELAEQKATEKQ---HITLALEKQK-LEEKRAFDSAVAKALEHHRSEI-----QAEQDRKI 467
L + K H+ AL Q+ L+E+ A A L+ E+ Q E+ RK+
Sbjct: 1643 HLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKL 1702
Query: 468 EEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFE------QNLSEK----LS 517
E ++ +++ R QL H + L +L+SE E +N EK ++
Sbjct: 1703 AE-QELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAIT 1761
Query: 518 EQELQFRRLSQEQVDNFTLDINTAYARL-RGIEQAVQ--SHAVAEEE 561
+ + L +EQ D + R+ + +EQ V+ H + E E
Sbjct: 1762 DAAMMAEELKKEQ------DTSAHLERMKKNLEQTVKDLQHRLDEAE 1802
Score = 47.4 bits (111), Expect = 5e-05
Identities = 98/473 (20%), Positives = 190/473 (40%), Gaps = 69/473 (14%)
Query: 187 EASSSSIRERPP--EEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAA 244
EA + ER EE+ A L ++++ + + L K ++D A V + A +N
Sbjct: 917 EAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 976
Query: 245 VQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKM 304
S + + +++ EKK+ Q + AL + + A ++ ++L K K +LE+
Sbjct: 977 KNLTEELSGLDETI---AKLTREKKALQ-EAHQQALDDLQ-AEEDKVNSLNKTKSKLEQQ 1031
Query: 305 KSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQA 364
+E++ ++E + VDL+ +K++ A+ E ++
Sbjct: 1032 VEDLESSLEQE---------------KKLRVDLERNKRKLEGDLKLAQ------ESILDL 1070
Query: 365 RDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSL-----IAHAHRRIDQLNREL- 418
+D K++LD + K L K+ + L I RI++L E+
Sbjct: 1071 END-KQQLDERLKK-----KDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIE 1124
Query: 419 ---AEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAE---QDRKIEEV-- 470
A + TEKQ A E ++L E+ V + +AE R +EE
Sbjct: 1125 AERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATL 1184
Query: 471 -RDAMENEMRTQLRRQAAAHTDHLRDVLRVQE--QELKSEFEQNLSEKLSEQELQFRRLS 527
+AM +R + A + + ++ RV++ ++ KSEF+ + + S E + S
Sbjct: 1185 QHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSK--S 1242
Query: 528 QEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETP 587
+ ++ + + RG + +Q +++E +K+ L EA + S + E+
Sbjct: 1243 KANLEKICRTLEDQLSEARGKNEEIQ-RSLSELTTQKSR---LQTEAGELSRQLEEKESI 1298
Query: 588 TIPLGSAVEAI------------KANCSDNEFTQALTAAIPPESLTRGVYSEE 628
L + +A + N + N AL ++ L R Y EE
Sbjct: 1299 VSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEE 1351
Score = 47.0 bits (110), Expect = 7e-05
Identities = 93/434 (21%), Positives = 180/434 (41%), Gaps = 58/434 (13%)
Query: 184 ALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQ------A 237
AL + + + E+ A L +Q + I L KS + + A + L A
Sbjct: 1492 ALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAA 1551
Query: 238 IAAQNAAVQAVNAHSNILKAAMD------NSEIAGEKKSAQWRTVE---GALKERRKAVD 288
+ + A + + +K+ +D + EI K++ Q RTVE AL ++ +
Sbjct: 1552 LEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQ-RTVETMQSALDAEVRSRN 1610
Query: 289 EAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDN--------- 339
EA K + +L +++ + +A ++ K H+ + +G+L + + LD+
Sbjct: 1611 EAIRLKKKMEGDLNEIEIQLSHANRQAAETLK-HLRSVQGQLKDTQLHLDDALRGQEDLK 1669
Query: 340 -----VVKKVQAAQSEAKVVSQYHELVVQARDDFKREL-DSITPEVLPGWKGMSVSDLAD 393
V ++ Q+E + + E +AR ++EL DS L + S+
Sbjct: 1670 EQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKK 1729
Query: 394 KLSTD--DLNSLIAHAHRRIDQLNRELAEQKAT-----------EKQHITLALEKQK--L 438
KL TD L S + A R D N E +KA ++Q + LE+ K L
Sbjct: 1730 KLETDLMQLQSEVEDASR--DARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1787
Query: 439 EE-----KRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMR--TQLRRQAAAHTD 491
E+ + D A AL+ + +IQ + R I E+ +E E + T+ + +
Sbjct: 1788 EQTVKDLQHRLDEAEQLALKGGKKQIQKLETR-IRELEFELEGEQKKNTESVKGLRKYER 1846
Query: 492 HLRDVLRVQEQELKSEFE-QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQ 550
++++ E++ K+ Q+L +KL + ++R ++E + + +E+
Sbjct: 1847 RVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEE 1906
Query: 551 AVQSHAVAEEEARK 564
A + +AE + K
Sbjct: 1907 AEERADIAESQVNK 1920
Score = 33.9 bits (76), Expect = 0.57
Identities = 75/368 (20%), Positives = 155/368 (42%), Gaps = 33/368 (8%)
Query: 217 ESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEK---KSAQW 273
E+L K + + LR T ++ I HS +L N + G + K
Sbjct: 654 ENLNKLMSN-LRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPN 712
Query: 274 RTVEGALKERRKAVDEAA---DALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAE--G 328
R + G K+R + ++ +A + +K+ EK+ + I+ + G A G
Sbjct: 713 RILYGDFKQRYRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLG 772
Query: 329 KLHNMIVD-LDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMS 387
L M D L ++ + QA + ++ ++V + F + + + + W M
Sbjct: 773 TLEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCIQYNIRSFMNVKHWPWMK 832
Query: 388 ----VSDLADKLSTD-DLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLE-EK 441
+ L T+ ++ ++ + D+L + A++K E++ +TL EK L+ +
Sbjct: 833 LFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQV 892
Query: 442 RAFDSAVAKALEHHRSEIQA--EQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRV 499
+A + A E I+A + + KI+EV + E+E ++ + A L D
Sbjct: 893 QAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDE--EEINAELTAKKRKLED---- 946
Query: 500 QEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAE 559
+ ELK + + +L L++ E + + ++ +V N T L G+++ + +
Sbjct: 947 ECSELKKDID-DLELTLAKVEKE-KHATENKVKNLT-------EELSGLDETIAKLTREK 997
Query: 560 EEARKAHQ 567
+ ++AHQ
Sbjct: 998 KALQEAHQ 1005
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 58.9 bits (141), Expect = 2e-08
Identities = 91/445 (20%), Positives = 181/445 (40%), Gaps = 57/445 (12%)
Query: 160 APAVQPEESLKTDHPEIGEGKPTPALSEASSSSIRE---------RPPEEVAARLAQQEK 210
A +Q +E L+ + E + A A + E EE L ++K
Sbjct: 880 AEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK 939
Query: 211 QEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKS 270
+ Q I+ L + LE+ + L+ + + A ++ + IL+ N ++A EKK
Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLEKVTTE-AKLKKLEEEQIILED--QNCKLAKEKKL 996
Query: 271 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKL 330
+ R E + +E + +L K K + E M + +E ++E + + KL
Sbjct: 997 LEDRIAEFTTNLTEE--EEKSKSLAKLKNKHEAMITDLEERLRREEK-QRQELEKTRRKL 1053
Query: 331 HNMIVDLDNVVKKVQAAQSEAKV------------VSQYHELVVQARDDFK--RELDSIT 376
DL + + ++QA +E K+ +++ E Q K REL+S
Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI 1113
Query: 377 PEVLPGWKGMSVS-DLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEK 435
E+ + S + A+K D L A D L+ A+Q+ K+ + + K
Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK 1173
Query: 436 QKLEEKRAFDSAVAKALEHHRSEI------QAEQDRKI----EEVRDAMENEM-----RT 480
+ LEE+ A + + S+ Q EQ +++ E+ + +ENE
Sbjct: 1174 KTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEV 1233
Query: 481 QLRRQAAAHTDHLRDVLRVQEQELKSEFEQ------NLSEKLSEQELQFRRL------SQ 528
++ Q ++H R + Q QEL+ +F + L++K+++ +++ + S
Sbjct: 1234 KVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSD 1293
Query: 529 EQVDNFTLDINTAYARLRGIEQAVQ 553
+ T D + ++L+ ++ +Q
Sbjct: 1294 SKSSKLTKDFSALESQLQDTQELLQ 1318
Score = 58.2 bits (139), Expect = 3e-08
Identities = 98/487 (20%), Positives = 199/487 (40%), Gaps = 58/487 (11%)
Query: 204 RLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAA--MDN 261
R + ++++ K SLA++LE+A+ Q A + + +++ ++ K+ ++
Sbjct: 1466 RAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEK 1525
Query: 262 SEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIE----------NA 311
S+ A E++ + +T L+E + DA L+ + L+ MK+ E
Sbjct: 1526 SKRALEQQVEEMKT---QLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEE 1582
Query: 312 KKKEVA--------------GAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQY 357
KKK++ + AA KL + DL+ + + EA + Q
Sbjct: 1583 KKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA--IKQL 1640
Query: 358 HELVVQAR------DDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRI 411
+L Q + DD + + I + K + + A+ + + + A R+
Sbjct: 1641 RKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSME-AEMIQLQEELAAAERAKRQA 1699
Query: 412 DQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDR------ 465
Q ELA++ A LALE+++ E R + + + LE + + DR
Sbjct: 1700 QQERDELADEIANSSGKGALALEEKRRLEARI--AQLEEELEEEQGNTELINDRLKKANL 1757
Query: 466 KIEEVRDAMENE-MRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFR 524
+I+++ + E Q A + L+V+ QE++ + ++ E +
Sbjct: 1758 QIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1817
Query: 525 RLSQEQVDNFTLDINTAYARLRGIEQAVQSHAV-AEEEARKAHQLWLSVEALKYSMKTSS 583
+L +EQ+DN T + A ++R E+ ++ + ++E R A Q + +K
Sbjct: 1818 QL-EEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLK 1876
Query: 584 AETPTIPLGSAVEAIKANCSDNEFTQAL-TAAIPPESLTRGVYSEETLRAR----FYAVQ 638
+ + EA +AN S + + L A +++ R V S + R F +
Sbjct: 1877 RQLEE----AEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPR 1932
Query: 639 KLARRVA 645
++AR+ A
Sbjct: 1933 RMARKGA 1939
Score = 50.4 bits (119), Expect = 6e-06
Identities = 77/367 (20%), Positives = 164/367 (44%), Gaps = 42/367 (11%)
Query: 204 RLAQQEK-QEQVKIESLAKSLEDALRQTASVTLQAI---AAQNAAVQAVNAHSNILKAAM 259
RL + E Q Q+ E L L++ L+ + +A A A Q + + L+A +
Sbjct: 867 RLTEMETLQSQLMAEKL--QLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARV 924
Query: 260 DNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGA 319
+ E + A+ + ++ ++E + ++E A K + E ++ ++ +++++
Sbjct: 925 EEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILE 984
Query: 320 KPHITAAEGK--LHNMIVDLD-NVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSIT 376
+ A+ K L + I + N+ ++ + ++S AK+ +++ ++ + +RE
Sbjct: 985 DQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEK--- 1041
Query: 377 PEVLPGWKGMSVSDLADKLSTD--DLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALE 434
+ + KL D DL+ IA +I +L +LA+++ E+ LA
Sbjct: 1042 -------QRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKE--EELQAALA-- 1090
Query: 435 KQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLR 494
++EE+ A + K + E + +I E+++ +E+E + R +A L
Sbjct: 1091 --RVEEEAAQKNMALKKIR--------ELESQISELQEDLESERAS--RNKAEKQKRDLG 1138
Query: 495 DVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQS 554
+ L + LK+E E L ++QEL+ +R + + TL+ A I++ Q
Sbjct: 1139 EEL----EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLE-EEAKTHEAQIQEMRQK 1193
Query: 555 HAVAEEE 561
H+ A EE
Sbjct: 1194 HSQAVEE 1200
Score = 40.0 bits (92), Expect = 0.008
Identities = 56/253 (22%), Positives = 99/253 (39%), Gaps = 39/253 (15%)
Query: 200 EVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAM 259
E A R AQQE+ E L D + ++ A+ + + L+
Sbjct: 1693 ERAKRQAQQERDE----------LADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQ 1742
Query: 260 DNSEIAGE---KKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEV 316
N+E+ + K + Q + L R + +A + + + +++K ++ +
Sbjct: 1743 GNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVK 1802
Query: 317 AGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSIT 376
+ K ITA E K+ + LDN K+ QAA + + + + V+ DD +R +
Sbjct: 1803 SKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAE--- 1859
Query: 377 PEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQ 436
D ADK ST R+ QL R+L E+ E Q + K
Sbjct: 1860 ----------QYKDQADKAST------------RLKQLKRQL-EEAEEEAQRANASRRKL 1896
Query: 437 KLEEKRAFDSAVA 449
+ E + A ++A A
Sbjct: 1897 QRELEDATETADA 1909
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 58.5 bits (140), Expect = 2e-08
Identities = 58/250 (23%), Positives = 109/250 (43%), Gaps = 28/250 (11%)
Query: 301 LEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHEL 360
+EK + +EN ++KE A E K L+ V K + + V Q E
Sbjct: 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRR----LEEVKLK---REERLRKVLQARER 587
Query: 361 VVQARDDFKRELDSITPEVLPGWKGMSVSDLAD-----KLSTDDLNSLIAHAHRRIDQLN 415
V Q +++ K++++ ++ + LA+ K + + + A + +
Sbjct: 588 VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR 647
Query: 416 RELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRD--- 472
+Q+ E++H L +K++ E++R +A AK L R + + EQ+R+ +E R+
Sbjct: 648 LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQER 707
Query: 473 ------------AMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQE 520
A + R Q R QA LR+Q+++L+ E E+ +K +Q
Sbjct: 708 REQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK-KKKEEQQR 766
Query: 521 LQFRRLSQEQ 530
L R+L +EQ
Sbjct: 767 LAERQLQEEQ 776
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 58.2 bits (139), Expect = 3e-08
Identities = 92/410 (22%), Positives = 176/410 (42%), Gaps = 61/410 (14%)
Query: 184 ALSEASSSSIRERPPEEVAARLAQQEKQE--QVKIESLAKSLEDALRQTASVTLQAIAAQ 241
A S +SS RE E+ Q+ E QVK E+L K L+ + A + +A++ Q
Sbjct: 767 AESSKASSITRELQGRELKLTNLQENLSEVSQVK-ETLEKELQILKEKFAEASEEAVSVQ 825
Query: 242 NAAVQAVNA-HSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEE 300
+ + VN H + M +S++ EK +E +E+ DE + L+KAKE+
Sbjct: 826 RSMQETVNKLHQKEEQFNMLSSDL--EKLRENLADMEAKFREK----DEREEQLIKAKEK 879
Query: 301 LEK-----MKSVIENA------------KKKEVAGAKPHITAAEGKLHNMIVDLDNVVKK 343
LE MK +N+ K+++V + +T A + ++++ K
Sbjct: 880 LENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVK 939
Query: 344 VQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLST--DDLN 401
+ +Q EA + ++ K+EL+ +SDL K+ T +
Sbjct: 940 AEQSQQEA----------AKKHEEEKKELE------------RKLSDLEKKMETSHNQCQ 977
Query: 402 SLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQA 461
L A R + + ++ + TL + KL+ R +S + + LE R QA
Sbjct: 978 ELKARYERATSETKTK--HEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK--QA 1033
Query: 462 EQDRKIEEVRDAME-NEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLS--EKLSE 518
++ + + DAM+ E T+ + + A + + + EL + E NL E+L++
Sbjct: 1034 DKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNK 1093
Query: 519 QELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 568
+ + + ++++ F +I T + +++ Q A+ EE + A +L
Sbjct: 1094 SK-ELLTVENQKMEEFRKEIET--LKQAAAQKSQQLSALQEENVKLAEEL 1140
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 58.2 bits (139), Expect = 3e-08
Identities = 92/410 (22%), Positives = 176/410 (42%), Gaps = 61/410 (14%)
Query: 184 ALSEASSSSIRERPPEEVAARLAQQEKQE--QVKIESLAKSLEDALRQTASVTLQAIAAQ 241
A S +SS RE E+ Q+ E QVK E+L K L+ + A + +A++ Q
Sbjct: 802 AESSKASSITRELQGRELKLTNLQENLSEVSQVK-ETLEKELQILKEKFAEASEEAVSVQ 860
Query: 242 NAAVQAVNA-HSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEE 300
+ + VN H + M +S++ EK +E +E+ DE + L+KAKE+
Sbjct: 861 RSMQETVNKLHQKEEQFNMLSSDL--EKLRENLADMEAKFREK----DEREEQLIKAKEK 914
Query: 301 LEK-----MKSVIENA------------KKKEVAGAKPHITAAEGKLHNMIVDLDNVVKK 343
LE MK +N+ K+++V + +T A + ++++ K
Sbjct: 915 LENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVK 974
Query: 344 VQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLST--DDLN 401
+ +Q EA + ++ K+EL+ +SDL K+ T +
Sbjct: 975 AEQSQQEA----------AKKHEEEKKELE------------RKLSDLEKKMETSHNQCQ 1012
Query: 402 SLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQA 461
L A R + + ++ + TL + KL+ R +S + + LE R QA
Sbjct: 1013 ELKARYERATSETKTK--HEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK--QA 1068
Query: 462 EQDRKIEEVRDAME-NEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLS--EKLSE 518
++ + + DAM+ E T+ + + A + + + EL + E NL E+L++
Sbjct: 1069 DKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNK 1128
Query: 519 QELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 568
+ + + ++++ F +I T + +++ Q A+ EE + A +L
Sbjct: 1129 SK-ELLTVENQKMEEFRKEIET--LKQAAAQKSQQLSALQEENVKLAEEL 1175
Score = 36.2 bits (82), Expect = 0.12
Identities = 31/124 (25%), Positives = 65/124 (52%), Gaps = 8/124 (6%)
Query: 404 IAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQ 463
+A A + ++ +ELA + QH+ L LE K+++ R A + ++++ E+
Sbjct: 378 VAKATSHVGEIEQELALARDGHDQHV-LELEA-KMDQLRTMVEAADREKVELLNQLE-EE 434
Query: 464 DRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQF 523
RK+E+++ +E E T+ + +H R++E E FE+ ++KL ++EL+
Sbjct: 435 KRKVEDLQFRVEEESITKGDLETQTKLEH----ARIKELEQSLLFEKTKADKL-QRELED 489
Query: 524 RRLS 527
R++
Sbjct: 490 TRVA 493
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 58.2 bits (139), Expect = 3e-08
Identities = 82/372 (22%), Positives = 168/372 (45%), Gaps = 35/372 (9%)
Query: 203 ARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNS 262
+ L + + Q K++SL K + AL T IA N + + S L+A + S
Sbjct: 2024 SELLKDKTHLQEKLQSLEKDSQ-ALSLTKCELENQIAQLNKEKELLVKESESLQARLSES 2082
Query: 263 EIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPH 322
+ EK + + +E AL E+ E A L +EE+ +++ IE + + A K
Sbjct: 2083 DY--EKLNVS-KALEAALVEK----GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQ 2135
Query: 323 ITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPG 382
+ AE KL + D++ KV+ + E ++ + ELV+ ++ K E++++ ++
Sbjct: 2136 LHIAE-KLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEM 2194
Query: 383 WKGMSVSDL---ADKLSTDDLNSLIAHAHRRIDQLNRELAEQKA--TEKQHITLALEKQK 437
+ + V +L + ++L I ++ +L++ L+ K+ EK+ + ++++
Sbjct: 2195 ARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEES 2254
Query: 438 -------LEEKRAFDSAVAKALEHHRSEIQAEQ--DRKIEEVRDAMENEMRTQLRRQAAA 488
+ + + AVA EQ D IEE E+++R + + A
Sbjct: 2255 KTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEE-----EHQLRNSIEKLRAR 2309
Query: 489 HTDHLRDVLRVQEQELKSEFEQNLSE---KLSEQELQFRRLSQE----QVDNFTLDINTA 541
+ L V +Q +SE +L + + E+EL+ R +QE + +N ++ T
Sbjct: 2310 LEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETL 2369
Query: 542 YARLRGIEQAVQ 553
A++ G+ Q+++
Sbjct: 2370 KAKIEGMTQSLR 2381
Score = 47.0 bits (110), Expect = 7e-05
Identities = 81/409 (19%), Positives = 185/409 (45%), Gaps = 44/409 (10%)
Query: 204 RLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSE 263
++ ++EK+ Q ++ +S + ++ + ++A Q QA N H N+L+A +D
Sbjct: 388 KIKEKEKEFQEELSRQQRSFQTLDQEC--IQMKARLTQELQ-QAKNMH-NVLQAELD--- 440
Query: 264 IAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHI 323
K ++ + +E L+E ++ + A A ++ + +++ +E KK+ K H
Sbjct: 441 ----KLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNL-LKSHS 495
Query: 324 TAAEGKLHNMIVDLDNVVKKVQAAQS-----EAKVVSQYHELVVQARDDFKRELDSITPE 378
++ ++ +L N+ + + +Q+ +AK SQ ++ ++ ++ +S+T E
Sbjct: 496 EQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQ-ETMLRDLQEKINQQENSLTLE 554
Query: 379 VLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHIT-LALEKQK 437
L ++V+DL + D L+ I+QLN +L++ + K ++ L L+K++
Sbjct: 555 KLK----LAVADLEKQ--RDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKE 608
Query: 438 LEEKR-------AFDSAVAKALEHHRSEIQAEQDR--------KIEEVRDAMENEMRTQL 482
EE + + S K L SE + Q + K ++++ NE L
Sbjct: 609 YEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTL 668
Query: 483 RRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFR-RLSQEQVDNFTLDINTA 541
+ +R++ V + + Q L+ +Q+ +F + Q++++N L +
Sbjct: 669 EMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQL 728
Query: 542 YARLRGIEQAVQ--SHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPT 588
++ +E +Q S+ + +++ R L E+L+ +K+ A T
Sbjct: 729 TGQVEDLEHKLQLLSNEIMDKD-RCYQDLHAEYESLRDLLKSKDASLVT 776
Score = 34.3 bits (77), Expect = 0.44
Identities = 62/356 (17%), Positives = 136/356 (38%), Gaps = 72/356 (20%)
Query: 255 LKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKK 314
L+ +D + +++ Q ++E AL+++++ V+ K E +++ + E+ +K
Sbjct: 23 LEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKT 82
Query: 315 ------EVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDF 368
E+ + + EG+L++ ++ + ++++ +SE + Q + + +
Sbjct: 83 KQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPC 142
Query: 369 KRELDSITPEVLPG--WKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEK 426
T + P + G DL +K N+E+ E+K E
Sbjct: 143 NTPQKIFTTPLTPSQYYSGSKYEDLKEKY-------------------NKEVEERKRLEA 183
Query: 427 QHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQA 486
+ AL+ +K + + + + H++ ++ + N RT +RR
Sbjct: 184 E--VKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDF 241
Query: 487 AAH-------------------------------TDHLRDVLRVQEQELKSEFEQNLSEK 515
+A + HL D L+ Q QEL++ K
Sbjct: 242 SASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRN--------K 293
Query: 516 LSEQELQFRRLSQE---QVDNF-TLDINTAYARLRGIEQAVQSHAVAEEEARKAHQ 567
++E EL+ + +E QV+ F L + A++ IE+ + +E R Q
Sbjct: 294 INELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQ 349
Score = 34.3 bits (77), Expect = 0.44
Identities = 56/330 (16%), Positives = 137/330 (41%), Gaps = 49/330 (14%)
Query: 206 AQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQA--------VNAHSNILKA 257
++Q+ +E +E+ K+++ L Q+ + + + A+N + + +N N L
Sbjct: 495 SEQKAREVCHLEAELKNIKQCLNQSQNFA-EEMKAKNTSQETMLRDLQEKINQQENSL-- 551
Query: 258 AMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKK--KE 315
++ ++A Q + LK+R +++ D L K ++E + + S +E KK +E
Sbjct: 552 TLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEE 611
Query: 316 VAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSI 375
+ K + + + ++ +++ + +Q+ + + + ++ ++ R L+
Sbjct: 612 LKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLE-- 669
Query: 376 TPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEK 435
+ ++L+ I + H +D + E+ QK L
Sbjct: 670 -------------------MDRENLSVEIRNLHNVLDSKSVEVETQK----------LAY 700
Query: 436 QKLEEKRAF-DSAVAKALEHH--RSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDH 492
+L++K F D K +E+ ++ Q +E + NE+ + R H ++
Sbjct: 701 MELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEY 760
Query: 493 --LRDVLRVQEQELKSEFEQNLSEKLSEQE 520
LRD+L+ ++ L + + S +Q+
Sbjct: 761 ESLRDLLKSKDASLVTNEDHQRSLLAFDQQ 790
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 58.2 bits (139), Expect = 3e-08
Identities = 58/249 (23%), Positives = 108/249 (43%), Gaps = 28/249 (11%)
Query: 302 EKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELV 361
EK + +EN ++KE A E K L+ V K + + V Q E V
Sbjct: 532 EKERQRLENLRRKEEAEQLRRQKVEEDKRRR----LEEVKLK---REERLRKVLQARERV 584
Query: 362 VQARDDFKRELDSITPEVLPGWKGMSVSDLAD-----KLSTDDLNSLIAHAHRRIDQLNR 416
Q +++ K++++ ++ + LA+ K + + + A + +
Sbjct: 585 EQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL 644
Query: 417 ELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRD---- 472
+Q+ E++H L +K++ E++R +A AK L R + + EQ+R+ +E R+
Sbjct: 645 RWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR 704
Query: 473 -----------AMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQEL 521
A + R Q R QA LR+Q+++L+ E E+ +K +Q L
Sbjct: 705 EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK-KKKEEQQRL 763
Query: 522 QFRRLSQEQ 530
R+L +EQ
Sbjct: 764 AERQLQEEQ 772
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 57.8 bits (138), Expect = 4e-08
Identities = 97/433 (22%), Positives = 169/433 (39%), Gaps = 73/433 (16%)
Query: 199 EEVAARLAQQEKQE-QVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKA 257
EE ++ Q EK++ Q I+ L + L++ + L+ + A+ + IL
Sbjct: 934 EEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAE---AKIKKMEEEILLL 990
Query: 258 AMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVA 317
NS+ EKK + R E + + + +E A L K + + E M S +E KKE
Sbjct: 991 EDQNSKFIKEKKLMEDRIAECSSQLAEE--EEKAKNLAKIRNKQEVMISDLEERLKKEEK 1048
Query: 318 GAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQ---ARDDFK----- 369
+ + A+ KL DL + + ++QA E K+ E +Q AR D +
Sbjct: 1049 -TRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN 1107
Query: 370 ------RELDSITPEVLPGWKGMSVS-DLADKLSTDDLNSLIAHAHRRIDQLNRELAEQK 422
REL + E+ ++ S + A+K D L A D L+ A+Q+
Sbjct: 1108 NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE 1167
Query: 423 ATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVR----------- 471
K+ +A K+ LEE+ A + + + E ++E+ +
Sbjct: 1168 LRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQ 1227
Query: 472 ----DAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQN------LSEKLSEQEL 521
D E ++ +Q A ++H R L Q QEL ++ + L+EK S+ +
Sbjct: 1228 GLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN 1287
Query: 522 QFRRLS---------------------------QEQVDNFTLDINTAYARLRGIEQ---A 551
+ +S QE + T +R+R +E+ +
Sbjct: 1288 ELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNS 1347
Query: 552 VQSHAVAEEEARK 564
+Q EEEARK
Sbjct: 1348 LQEQQEEEEEARK 1360
Score = 56.2 bits (134), Expect = 1e-07
Identities = 101/499 (20%), Positives = 210/499 (42%), Gaps = 63/499 (12%)
Query: 102 KSIQSGPLKISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAP 161
K ++ +I+ + E + K ++ +KQK D A + + DTL A
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEA------LKTELEDTLDTTAA 1164
Query: 162 AVQPEESLKTDHP-EIGEGKPTPALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLA 220
++ L+T E+ E K AL E + + A++ ++ +E L+
Sbjct: 1165 ----QQELRTKREQEVAELKK--ALEEETKNH---------EAQIQDMRQRHATALEELS 1209
Query: 221 KSLEDALRQTASV--TLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEG 278
+ LE A R A++ Q + N + + +L+ SE +K AQ + +
Sbjct: 1210 EQLEQAKRFKANLEKNKQGLETDN---KELACEVKVLQQVKAESEHKRKKLDAQVQELHA 1266
Query: 279 ALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLD 338
+ E + E A+ K + EL+ + +++E A+KK + AK + E +L + L
Sbjct: 1267 KVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAK-DAASLESQLQDTQELLQ 1325
Query: 339 -------NVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGM----- 386
N+ +++ + E + + E +AR + ++++ ++ ++ K +
Sbjct: 1326 EETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLG 1385
Query: 387 ---SVSDLADKLSTD--DLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQK---- 437
S+ + KL D L+ + D+L + + E +T+ L+ Q+
Sbjct: 1386 TIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEK-TKNRLQQELDDLTVDLDHQRQVAS 1444
Query: 438 -LEEK-RAFDSAVAK--------ALEHHRSEIQA-EQDRKIEEVRDAMEN--EMRTQLRR 484
LE+K + FD +A+ A E R+E +A E++ K + A+E E + + R
Sbjct: 1445 NLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFER 1504
Query: 485 QAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYAR 544
Q + D++ ++ K+ E S++ EQ+++ R E++++ A R
Sbjct: 1505 QNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLR 1564
Query: 545 LRGIEQAVQSHAVAEEEAR 563
L QA+++ + + R
Sbjct: 1565 LEVNMQAMKAQFERDLQTR 1583
Score = 48.1 bits (113), Expect = 3e-05
Identities = 105/509 (20%), Positives = 198/509 (38%), Gaps = 117/509 (22%)
Query: 188 ASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQA 247
A SI R EE R + ++++ K SLA++LE+AL Q +
Sbjct: 1458 AEEKSISARYAEE-RDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDL 1516
Query: 248 VNAHSNILKAA--MDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMK 305
+++ ++ K ++ S+ A E++ + RT L++ +A + DA L+ + ++ MK
Sbjct: 1517 MSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATE---DAKLRLEVNMQAMK 1573
Query: 306 SVIE---------NAKKK------------EVAGAKPHITAAEGKLHNMIVDLDNVVKKV 344
+ E N +KK E+ + A M +DL ++ ++
Sbjct: 1574 AQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQI 1633
Query: 345 QAA-QSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSL 403
+AA ++ +V+ Q +L Q +D ++REL+ + S D++
Sbjct: 1634 EAANKARDEVIKQLRKLQAQMKD-YQRELEEA------------------RASRDEI--- 1671
Query: 404 IAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQ--- 460
A+ K +EK+ +L E +L+E+ A + E R E+
Sbjct: 1672 --------------FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEI 1717
Query: 461 ---------------------AEQDRKIEEVRDAME-------------NEMRTQL--RR 484
A+ + ++EE + ME + + +L R
Sbjct: 1718 TNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER 1777
Query: 485 QAAAHTDHLRDVLRVQEQELKSEFEQ-------NLSEKLSEQELQFRRLSQEQVDNFTLD 537
AA +D+ R L Q +ELK++ ++ +S E + +L +EQ++ +
Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQL-EEQLEQEAKE 1836
Query: 538 INTAYARLRGIEQAVQS-HAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVE 596
A +R E+ ++ E+E R A Q +E MK + + E
Sbjct: 1837 RAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEE----AEEE 1892
Query: 597 AIKANCSDNEFTQALTAAIPP-ESLTRGV 624
A +AN S + + L A E L+R V
Sbjct: 1893 ATRANASRRKLQRELDDATEANEGLSREV 1921
Score = 47.8 bits (112), Expect = 4e-05
Identities = 114/573 (19%), Positives = 226/573 (39%), Gaps = 57/573 (9%)
Query: 73 ESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKESKQPASQLQKQK 132
E+ K + K+ + V + + +Q K+S + E + AS+LQ +
Sbjct: 1230 ETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNEL 1289
Query: 133 GDTPASATAPTEAAQI-ISAAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALSEASSS 191
+ +T EA + I A D S+ + +E L+ + + E +
Sbjct: 1290 DNV---STLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKN 1346
Query: 192 SIRERPPEEVAAR-------LAQQEKQEQVK---------IESLAKSLEDALRQTASVTL 235
S++E+ EE AR LA Q + K IESL ++ + L+ +++
Sbjct: 1347 SLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS- 1405
Query: 236 QAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE--AADA 293
Q + + A + N L+ +D+ + + + R V L++++K D+ A +
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQ----RQVASNLEKKQKKFDQLLAEEK 1461
Query: 294 LLKAK--EELEKMKSVIENAKKKEVAGAKPHITAAEGK-------------LHNMIVDLD 338
+ A+ EE ++ ++ + K ++ A+ A E K + +++ D
Sbjct: 1462 SISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKD 1521
Query: 339 NVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLP---GWKGMSVSDLADKL 395
+V K V + + + Q E + ++ + EL + L + M D
Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1581
Query: 396 STDDLNSLIAHAHRRIDQLNREL-AEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEH 454
+ D+ N R + + REL AE + KQ K+K+E A +A
Sbjct: 1582 TRDEQNE---EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANK 1638
Query: 455 HRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQ--NL 512
R E+ +Q RK++ + E+ +A A D + + E++LKS + L
Sbjct: 1639 ARDEV-IKQLRKLQAQMKDYQRELE-----EARASRDEIFAQSKESEKKLKSLEAEILQL 1692
Query: 513 SEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSV 572
E+L+ E R QE+ + N+A + +++ + A + + + ++
Sbjct: 1693 QEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNM 1752
Query: 573 EALKYSMKTSSAETPTIPLGSAVEAIKANCSDN 605
E L + ++ + T+ A E A SDN
Sbjct: 1753 ELLNDRFRKTTLQVDTLNAELAAERSAAQKSDN 1785
Score = 32.0 bits (71), Expect = 2.2
Identities = 53/252 (21%), Positives = 105/252 (41%), Gaps = 34/252 (13%)
Query: 412 DQLNRELAEQKATEKQHITLALEKQKLEE-KRAFDSAVAKALEHHRSEIQAEQDRK---- 466
+QL E E+ LA +KQ+LEE +S V + E R++I + +K
Sbjct: 894 EQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEE--EEERNQILQNEKKKMQAH 951
Query: 467 IEEVRDAMENEMRTQLRRQAAAHTDHLR------DVLRVQEQELKSEFEQNLSE-KLSEQ 519
I+++ + ++ E + + Q T + ++L +++Q K E+ L E +++E
Sbjct: 952 IQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011
Query: 520 ELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSM 579
Q +E+ N N + +E+ ++ +E KA + K
Sbjct: 1012 SSQLAE-EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKR--------KLDG 1062
Query: 580 KTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRAR--FYAV 637
+T+ + L + ++ +K + E + L A L RG +ETL V
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKE--EELQGA-----LARG--DDETLHKNNALKVV 1113
Query: 638 QKLARRVAMIDE 649
++L ++A + E
Sbjct: 1114 RELQAQIAELQE 1125
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 57.4 bits (137), Expect = 5e-08
Identities = 85/427 (19%), Positives = 185/427 (43%), Gaps = 53/427 (12%)
Query: 186 SEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAV 245
+E S +E E A++ +Q + + K++ + L++ + + +
Sbjct: 1521 AELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEME 1580
Query: 246 QAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELE-KM 304
+ HS +++ + E A + + + +E L+E E +L+ K ELE K+
Sbjct: 1581 RMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEY----EDKQKVLREKRELEGKL 1636
Query: 305 KSVIENAKKKEVAGAK---PHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE-- 359
++ + +++ K + + L + + LD++ + + A++ +Q E
Sbjct: 1637 ATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESE 1696
Query: 360 ----LVVQARDDFKRELDSITPEVLPGWKGMSV------------SDLADKLSTD--DLN 401
V+AR + E++ + ++ K + +++ ++L D D+N
Sbjct: 1697 FTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMN 1756
Query: 402 SLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHR--SEI 459
L+ + Q +R+LA+ + Q EKQ+L+EK + + LE +
Sbjct: 1757 ELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSL 1816
Query: 460 QAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQ 519
+ Q+ KI E+ +E E RTQ++R + L L+ ++L E +Q ++ + E+
Sbjct: 1817 VSRQEAKIRELETRLEFE-RTQVKR-----LESLASRLKENMEKLTEERDQRIAAENREK 1870
Query: 520 ELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEA-RKAHQLWLSVEALKYS 578
E Q +RL ++ LR ++ + A E EA RK H+L + +E+L+ +
Sbjct: 1871 E-QNKRLQRQ---------------LRDTKEEMGELARKEAEASRKKHELEMDLESLEAA 1914
Query: 579 MKTSSAE 585
++ A+
Sbjct: 1915 NQSLQAD 1921
Score = 50.1 bits (118), Expect = 8e-06
Identities = 78/370 (21%), Positives = 149/370 (40%), Gaps = 59/370 (15%)
Query: 185 LSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAA 244
+SE +S ER E A++L E E+++ E K L+ A+ Q
Sbjct: 1291 ISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQ--------TQYDALKKQMEV 1342
Query: 245 VQAVNAHSNILKAAMDNSEIAGEKKSAQWRT-VEGALKE----RRKAVDEAADAL---LK 296
++ + +++AA N E+ + +WR E A++E +++ E D L +
Sbjct: 1343 MEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQ 1402
Query: 297 AKEELEKM-----------KSVIENAKKK------EVAGAKPHITAAEGKLHNMIVDLDN 339
K +LE+ + ++ KKK E+ K H+ + + H +L+
Sbjct: 1403 NKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNH----ELEK 1458
Query: 340 VVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDD 399
++ + S+A +Q +L R+ +RE D + E L +L D
Sbjct: 1459 KQRRFDSELSQAHEEAQREKL---QREKLQREKDMLLAEAF---------SLKQQLEEKD 1506
Query: 400 LNSLIAHAHRRIDQLNRELAEQKATE-KQHITLALEKQKLEEKRAFDSAVAKALEHHRSE 458
++ IA +++ L EL + + E K +LA K++L + A + L+
Sbjct: 1507 MD--IAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGT 1564
Query: 459 IQAEQDRKI------EEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNL 512
IQ + K+ E +R EM ++ A + L+ E +L+ E+E
Sbjct: 1565 IQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEAR-QSCQKKLKQMEVQLEEEYEDKQ 1623
Query: 513 SEKLSEQELQ 522
++EL+
Sbjct: 1624 KVLREKRELE 1633
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 57.4 bits (137), Expect = 5e-08
Identities = 85/427 (19%), Positives = 185/427 (43%), Gaps = 53/427 (12%)
Query: 186 SEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAV 245
+E S +E E A++ +Q + + K++ + L++ + + +
Sbjct: 1521 AELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEME 1580
Query: 246 QAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELE-KM 304
+ HS +++ + E A + + + +E L+E E +L+ K ELE K+
Sbjct: 1581 RMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEY----EDKQKVLREKRELEGKL 1636
Query: 305 KSVIENAKKKEVAGAK---PHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHE-- 359
++ + +++ K + + L + + LD++ + + A++ +Q E
Sbjct: 1637 ATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESE 1696
Query: 360 ----LVVQARDDFKRELDSITPEVLPGWKGMSV------------SDLADKLSTD--DLN 401
V+AR + E++ + ++ K + +++ ++L D D+N
Sbjct: 1697 FTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMN 1756
Query: 402 SLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHR--SEI 459
L+ + Q +R+LA+ + Q EKQ+L+EK + + LE +
Sbjct: 1757 ELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSL 1816
Query: 460 QAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQ 519
+ Q+ KI E+ +E E RTQ++R + L L+ ++L E +Q ++ + E+
Sbjct: 1817 VSRQEAKIRELETRLEFE-RTQVKR-----LESLASRLKENMEKLTEERDQRIAAENREK 1870
Query: 520 ELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEA-RKAHQLWLSVEALKYS 578
E Q +RL ++ LR ++ + A E EA RK H+L + +E+L+ +
Sbjct: 1871 E-QNKRLQRQ---------------LRDTKEEMGELARKEAEASRKKHELEMDLESLEAA 1914
Query: 579 MKTSSAE 585
++ A+
Sbjct: 1915 NQSLQAD 1921
Score = 50.1 bits (118), Expect = 8e-06
Identities = 78/370 (21%), Positives = 149/370 (40%), Gaps = 59/370 (15%)
Query: 185 LSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAA 244
+SE +S ER E A++L E E+++ E K L+ A+ Q
Sbjct: 1291 ISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQ--------TQYDALKKQMEV 1342
Query: 245 VQAVNAHSNILKAAMDNSEIAGEKKSAQWRT-VEGALKE----RRKAVDEAADAL---LK 296
++ + +++AA N E+ + +WR E A++E +++ E D L +
Sbjct: 1343 MEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQ 1402
Query: 297 AKEELEKM-----------KSVIENAKKK------EVAGAKPHITAAEGKLHNMIVDLDN 339
K +LE+ + ++ KKK E+ K H+ + + H +L+
Sbjct: 1403 NKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNH----ELEK 1458
Query: 340 VVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDD 399
++ + S+A +Q +L R+ +RE D + E L +L D
Sbjct: 1459 KQRRFDSELSQAHEEAQREKL---QREKLQREKDMLLAEAF---------SLKQQLEEKD 1506
Query: 400 LNSLIAHAHRRIDQLNRELAEQKATE-KQHITLALEKQKLEEKRAFDSAVAKALEHHRSE 458
++ IA +++ L EL + + E K +LA K++L + A + L+
Sbjct: 1507 MD--IAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGT 1564
Query: 459 IQAEQDRKI------EEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNL 512
IQ + K+ E +R EM ++ A + L+ E +L+ E+E
Sbjct: 1565 IQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEAR-QSCQKKLKQMEVQLEEEYEDKQ 1623
Query: 513 SEKLSEQELQ 522
++EL+
Sbjct: 1624 KVLREKRELE 1633
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 56.6 bits (135), Expect = 8e-08
Identities = 77/416 (18%), Positives = 176/416 (42%), Gaps = 44/416 (10%)
Query: 185 LSEASSSSIRERPPEEVAARLAQQEKQE-QVKIESLAKSLEDALRQTASVTLQAIAAQNA 243
L+E + + + E +L +QEK + QV +E + SLE + V L+ ++
Sbjct: 1516 LTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSE 1575
Query: 244 AVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEK 303
+ V ++ NS+ A E ++ L ++ ++A K + +L +
Sbjct: 1576 LDRKVIEKDEEIEQLKRNSQRAAE-------ALQSVLDAEIRSRNDALRLKKKMEGDLNE 1628
Query: 304 MKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQ 363
M+ + ++ + ++A + H+ +G+L + + LD+ ++ + + + +V + + L+++
Sbjct: 1629 MEIQLGHSNR-QMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLE 1687
Query: 364 ARDDFKRELDSI-TPEVLPGWKGMSVSDLADKLSTDD---------LNSLIAHAHRRIDQ 413
++ K L+ L + + SD L + + L + IA ++
Sbjct: 1688 ELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVEN 1747
Query: 414 LNRELAEQKATEKQHIT----LALEKQKLEEKRAFDSAVAKALEHHRSEIQ--------- 460
+E + K+ IT +A E +K ++ A + K LE ++Q
Sbjct: 1748 SIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1807
Query: 461 -----AEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFE------ 509
+Q +K+E +ENE+ + +R A A + +V+E ++E +
Sbjct: 1808 ALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILR 1867
Query: 510 -QNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARK 564
Q+L +KL + ++R ++E + ++ +E+A + +AE + K
Sbjct: 1868 LQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNK 1923
Score = 52.8 bits (125), Expect = 1e-06
Identities = 102/505 (20%), Positives = 192/505 (38%), Gaps = 52/505 (10%)
Query: 110 KISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESL 169
K S +S++ K + QL++ K A A + ++ + + E+
Sbjct: 1298 KESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEA 1357
Query: 170 KTDHPEIGEGKPTPALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQ 229
K + ALS+A+S + R E A +E +E K LA+ L++A
Sbjct: 1358 KAELQR--------ALSKANSEVAQWRTKYETDAIQRTEELEEAKK--KLAQRLQEAEEN 1407
Query: 230 TASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDE 289
T + + + + Q + L ++ S A + R + L E ++ +DE
Sbjct: 1408 TETANSKCASLEKTK-QRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDE 1466
Query: 290 AADALLKAKEELEKMKSVIENAKK--KEVAGAKPHITAAEGKLHNMIVDLDNVV----KK 343
+ L A++E + + + + +EV + L I DL + K
Sbjct: 1467 SQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKN 1526
Query: 344 VQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSL 403
+Q A+ K+V Q + A ++ + L+ ++L +S +L+
Sbjct: 1527 LQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVK-------SELDRK 1579
Query: 404 IAHAHRRIDQLNRELAEQKATEKQHITLALEKQ------KLEEKRAFDSAVAKALEHHRS 457
+ I+QL R Q+A E L E + +L++K D + H +
Sbjct: 1580 VIEKDEEIEQLKRN--SQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSN 1637
Query: 458 EIQAEQDRKIEEVRDAMENEM---------RTQLRRQAAAHTDHLRDVLRVQEQELKSEF 508
AE + + V+ +++ L+ Q A + +L + +E+K
Sbjct: 1638 RQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAI-VERRNGLLLEELEEMKVAL 1696
Query: 509 EQN-LSEKLSEQEL-------QFRRLSQEQVDNFTLDINTAYARLRG-IEQAVQSHAVAE 559
EQ + +LSEQEL Q + N + A+ + +E ++Q AE
Sbjct: 1697 EQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAE 1756
Query: 560 EEARKA-HQLWLSVEALKYSMKTSS 583
E+A+KA + E LK TS+
Sbjct: 1757 EKAKKAITDAAMMAEELKKEQDTSA 1781
Score = 44.3 bits (103), Expect = 4e-04
Identities = 102/506 (20%), Positives = 211/506 (41%), Gaps = 64/506 (12%)
Query: 110 KISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESL 169
K SS+ + + + ++++K+K T +E + L+ ++Q
Sbjct: 950 KCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQ 1009
Query: 170 KTDHPEIGEGKPTPALSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALR- 228
D ++ E K + ++ E+ +++ L +QEK+ + +E + LE L+
Sbjct: 1010 TLDDLQVEEDKVNGLIK---INAKLEQQTDDLEGSL-EQEKKLRADLERAKRKLEGDLKM 1065
Query: 229 -QTASVTLQAIAAQ-NAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKA 286
Q + + L+ Q ++ + L+A +D+ ++ + + + ++ ++E +
Sbjct: 1066 SQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEE 1125
Query: 287 VDEAADALLKAK---------EELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDL 337
++ A+ L+AK ELE++ +E A A + + E + M DL
Sbjct: 1126 IE--AEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMN-KKREAEFQKMRRDL 1182
Query: 338 DNVVKKVQA---------AQSEAKVVSQYHEL------VVQARDDFKRELDSITPEVLPG 382
+ + +A A S A++ Q L + + + + K E+D + +
Sbjct: 1183 EEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEAL 1242
Query: 383 WKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKAT-EKQHITLALEKQKLEEK 441
K S + + D + + A ++ QL +L QKA + Q+ L+ ++EEK
Sbjct: 1243 SKSKSNIERTCRTVEDQFSEIKAKDEQQT-QLIHDLNMQKARLQTQNGELS---HRVEEK 1298
Query: 442 RAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAH----TDHLRDVL 497
+ S + K+ + +++EE++ ME E + + A AH + H D+L
Sbjct: 1299 ESLISQLTKSKQ--------ALTQQLEELKRQMEEETKA---KNAMAHALQSSRHDCDLL 1347
Query: 498 RVQ---EQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQS 554
R Q EQE K+E ++ LS K + + Q+R + T ++ A +L Q
Sbjct: 1348 REQYEEEQEAKAELQRALS-KANSEVAQWRTKYETDAIQRTEELEEAKKKL------AQR 1400
Query: 555 HAVAEEEARKAHQLWLSVEALKYSMK 580
AEE A+ S+E K ++
Sbjct: 1401 LQEAEENTETANSKCASLEKTKQRLQ 1426
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 56.6 bits (135), Expect = 8e-08
Identities = 112/527 (21%), Positives = 213/527 (40%), Gaps = 94/527 (17%)
Query: 99 LPKKSIQSGPLKISSVSEVMKESKQPAS------QLQKQKGDTPASATAPTEAAQIISAA 152
+ K+ + S L + SE ++ KQ + Q+ KQ +T + T + ++ +
Sbjct: 776 MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETK-IQHEELNNRI 834
Query: 153 GDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALSEASSSSIRERPPEEVAARLAQQEK-- 210
T++ +E+L T+ + + + S +S S E+ ++ A + EK
Sbjct: 835 QTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTC 894
Query: 211 -----QEQVKIES-------LAKSLEDALRQTASVTLQAIAAQNAAVQAVNA------HS 252
Q QV++E+ L KSLE + + L+ + Q +QA N
Sbjct: 895 KELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEE 954
Query: 253 NILKAAMDNSEIAGEKKSAQWRTVEGALK----ERRKAVDEAADALLKAKEEL--EKMK- 305
L+ ++ + + E+K Q ++G LK ++ + ++ L +A +EL EK K
Sbjct: 955 QQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKI 1014
Query: 306 SVIENAKKKEVAGAKPHITAAEGKLHNMIV---DLDNVVKKVQAAQ----SEAKVVSQYH 358
SV++N +K K + G+ ++ DL +V +K+ AQ S + +
Sbjct: 1015 SVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQN 1074
Query: 359 ELVVQAR--------DDFKRE---------LDSITPEVLPGWKGMSVSDLA-DKLSTDDL 400
+L+ + + D K+E L I E K + +L +K ++
Sbjct: 1075 KLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKE-----KSLKEKELVNEKSKLAEI 1129
Query: 401 NSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQ 460
+ + I +LN EL K + IT + ++L L + E+Q
Sbjct: 1130 EEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQL-------------LIQQKLELQ 1176
Query: 461 AEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEF---EQNLSEKLS 517
+ D ++ A+E E R Q L+D ++ +E+ELK EF E L ++
Sbjct: 1177 GKAD----SLKAAVEQEKRNQ---------QILKDQVKKEEEELKKEFIEKEAKLHSEIK 1223
Query: 518 EQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARK 564
E+E+ ++ +E T+ I L +++ QS E K
Sbjct: 1224 EKEVGMKK-HEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEK 1269
Score = 50.8 bits (120), Expect = 5e-06
Identities = 102/527 (19%), Positives = 210/527 (39%), Gaps = 69/527 (13%)
Query: 110 KISSVSEVMKESKQPASQLQKQKGDTPASATA-PTEAAQIISAAGDTLSVPAPAVQPEES 168
KI ++ ++++SK+ S L+K++ D A A E A + ++ Q E
Sbjct: 524 KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEK 583
Query: 169 LKTD-----------HPEIGEGKPTPALSEASSSSIRERPPEEVAARLAQQEKQEQVKIE 217
LK H ++ E K ++ S+ E + +EK Q+ I+
Sbjct: 584 LKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQ 643
Query: 218 SLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVE 277
AK+ + L A AA+ A + H + + A+ + + K + Q V
Sbjct: 644 IKAKT---------ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVT 694
Query: 278 GALKERRKAVDEAADALLKAKEE---LEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMI 334
L+++++ + L + KE+ LE+ +E KK A + + E L ++
Sbjct: 695 AKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQ 754
Query: 335 VDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRE---LDSITPEVLPGWKGMSVSDL 391
A +K + E+V R D +++ L+SI + ++ +
Sbjct: 755 QQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK-------LTKQEE 807
Query: 392 ADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFD--SAVA 449
++ D +L + ++LN + + TE Q + + E E D S V+
Sbjct: 808 EKQILKQDFETLSQETKIQHEELNNRI-QTTVTELQKVKMEKEALMTELSTVKDKLSKVS 866
Query: 450 KALEHHRSEIQAEQDRKIEEVRDAME--NEMRTQLRRQAAAHTDHLRDVLRVQEQELKSE 507
+L++ +SE + E + + D + E++ QL+ Q + + L+ +++ELK
Sbjct: 867 DSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQ-------MENTLK-EQKELKKS 918
Query: 508 FEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQ 567
E+ EK + +L+ L++N+ EQ +Q+ ++ ++ Q
Sbjct: 919 LEK---EKEASHQLK-------------LELNSMQ------EQLIQAQNTLKQNEKEEQQ 956
Query: 568 LWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAA 614
L ++ LK S + + + + ++ +N+ Q LT A
Sbjct: 957 LQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQA 1003
Score = 42.7 bits (99), Expect = 0.001
Identities = 83/431 (19%), Positives = 168/431 (38%), Gaps = 46/431 (10%)
Query: 185 LSEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAA 244
+++ S ER E A + + +E K ++ + L+ L Q + A+ +
Sbjct: 172 IADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELV 231
Query: 245 VQAVNAHSNILKAAMDNSEIAGE--KKSAQWRTVEGALKERRKAVDEAADALLKAKEELE 302
+ L+ ++ ++ E K +Q+ + E + + R + + + +EL+
Sbjct: 232 QVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQ 291
Query: 303 KMKSVI-----------ENAKKKEVAGAK---PHITAAEGK------LHNMIVDLDNVVK 342
K+KS + EN KKE K H + K LH +D +
Sbjct: 292 KLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQS 351
Query: 343 KVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNS 402
++ A+++ + +A K EL EV ++ + + ++
Sbjct: 352 RLSASETSLHRIHVELSEKGEATQKLKEELS----EVETKYQHLKAEFKQLQQQREEKEQ 407
Query: 403 LIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAE 462
I+QL+ +L E TE+Q L +L+E+R S E +++Q +
Sbjct: 408 HGLQLQSEINQLHSKLLE---TERQ---LGEAHGRLKEQRQLSSEKLMDKEQQVADLQLK 461
Query: 463 QDRKIEEVRDAMEN--EMRTQLRRQAAAHTDH--LRDVLRVQEQELKSEFEQNL------ 512
R E++++ + N E++ QL + H + L+ + +E +++ EQ L
Sbjct: 462 LSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDK 521
Query: 513 SEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSV 572
+K+ E ++ S+E + + YA+++ E AV + K H L V
Sbjct: 522 DQKIQNLEALLQK-SKENISLLEKEREDLYAKIQAGEGET---AVLNQLQEKNHTLQEQV 577
Query: 573 EALKYSMKTSS 583
L +K S
Sbjct: 578 TQLTEKLKNQS 588
Score = 40.4 bits (93), Expect = 0.006
Identities = 53/261 (20%), Positives = 114/261 (43%), Gaps = 26/261 (9%)
Query: 203 ARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQN--AAVQAVNAHSNI----LK 256
A L Q +++ +++ K+L+D ++ + + + ++ A ++ + L
Sbjct: 1085 ATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLN 1144
Query: 257 AAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEV 316
+ + ++ K+ + + L +++ + AD+L A E+ ++ + ++++ KKE
Sbjct: 1145 EELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEE 1204
Query: 317 AGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSIT 376
K E KLH+ I + + +KK + ++EAK+ Q L L ++
Sbjct: 1205 EELKKEFIEKEAKLHSEIKEKEVGMKKHE--ENEAKLTMQITAL--------NENLGTVK 1254
Query: 377 PEVLPGWKGMS--VSDLADKLSTDDLNSLIA--HAHRRIDQLNRELAEQKATEKQHITLA 432
E W+ VS+L + TDDL IA A + +Q R ++ + +
Sbjct: 1255 KE----WQSSQRRVSEL--EKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEK 1308
Query: 433 LEKQKLEEKRAFDSAVAKALE 453
L+ + LE +R D+ A E
Sbjct: 1309 LQTKVLELQRKLDNTTAAVQE 1329
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.126 0.340
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,889,878
Number of Sequences: 37866
Number of extensions: 1159382
Number of successful extensions: 8268
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 74
Number of HSP's successfully gapped in prelim test: 841
Number of HSP's that attempted gapping in prelim test: 6060
Number of HSP's gapped (non-prelim): 2368
length of query: 757
length of database: 18,247,518
effective HSP length: 110
effective length of query: 647
effective length of database: 14,082,258
effective search space: 9111220926
effective search space used: 9111220926
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.