Search of human proteins with 153946393

Search of human proteins with 153946393

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|153946393 macrophage stimulating 1 receptor precursor [Homo
sapiens]
         (1400 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|153946393 macrophage stimulating 1 receptor precursor [Homo s...  2877   0.0  
gi|42741655 met proto-oncogene isoform b precursor [Homo sapiens]     720   0.0  
gi|188595716 met proto-oncogene isoform a precursor [Homo sapiens]    713   0.0  
gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens]              228   4e-59
gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]     226   2e-58
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]     222   2e-57
gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]     222   2e-57
gi|54607018 RYK receptor-like tyrosine kinase isoform 2 [Homo sa...   214   4e-55
gi|54607020 RYK receptor-like tyrosine kinase isoform 1 [Homo sa...   213   8e-55
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur...   207   6e-53
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu...   206   1e-52
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs...   206   1e-52
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu...   204   6e-52
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu...   201   3e-51
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu...   201   3e-51
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu...   201   3e-51
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu...   201   3e-51
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu...   201   3e-51
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...   198   3e-50
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu...   196   2e-49
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu...   196   2e-49
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu...   196   2e-49
gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo...   196   2e-49
gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo...   196   2e-49
gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo...   196   2e-49
gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo...   196   2e-49
gi|119395738 insulin receptor isoform Short precursor [Homo sapi...   196   2e-49
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]   196   2e-49
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]   195   3e-49
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur...   194   5e-49

>gi|153946393 macrophage stimulating 1 receptor precursor [Homo
            sapiens]
          Length = 1400

 Score = 2877 bits (7459), Expect = 0.0
 Identities = 1400/1400 (100%), Positives = 1400/1400 (100%)

Query: 1    MELLPPLPQSFLLLLLLPAKPAAGEDWQCPRTPYAASRDFDVKYVVPSFSAGGLVQAMVT 60
            MELLPPLPQSFLLLLLLPAKPAAGEDWQCPRTPYAASRDFDVKYVVPSFSAGGLVQAMVT
Sbjct: 1    MELLPPLPQSFLLLLLLPAKPAAGEDWQCPRTPYAASRDFDVKYVVPSFSAGGLVQAMVT 60

Query: 61   YEGDRNESAVFVAIRNRLHVLGPDLKSVQSLATGPAGDPGCQTCAACGPGPHGPPGDTDT 120
            YEGDRNESAVFVAIRNRLHVLGPDLKSVQSLATGPAGDPGCQTCAACGPGPHGPPGDTDT
Sbjct: 61   YEGDRNESAVFVAIRNRLHVLGPDLKSVQSLATGPAGDPGCQTCAACGPGPHGPPGDTDT 120

Query: 121  KVLVLDPALPALVSCGSSLQGRCFLHDLEPQGTAVHLAAPACLFSAHHNRPDDCPDCVAS 180
            KVLVLDPALPALVSCGSSLQGRCFLHDLEPQGTAVHLAAPACLFSAHHNRPDDCPDCVAS
Sbjct: 121  KVLVLDPALPALVSCGSSLQGRCFLHDLEPQGTAVHLAAPACLFSAHHNRPDDCPDCVAS 180

Query: 181  PLGTRVTVVEQGQASYFYVASSLDAAVAASFSPRSVSIRRLKADASGFAPGFVALSVLPK 240
            PLGTRVTVVEQGQASYFYVASSLDAAVAASFSPRSVSIRRLKADASGFAPGFVALSVLPK
Sbjct: 181  PLGTRVTVVEQGQASYFYVASSLDAAVAASFSPRSVSIRRLKADASGFAPGFVALSVLPK 240

Query: 241  HLVSYSIEYVHSFHTGAFVYFLTVQPASVTDDPSALHTRLARLSATEPELGDYRELVLDC 300
            HLVSYSIEYVHSFHTGAFVYFLTVQPASVTDDPSALHTRLARLSATEPELGDYRELVLDC
Sbjct: 241  HLVSYSIEYVHSFHTGAFVYFLTVQPASVTDDPSALHTRLARLSATEPELGDYRELVLDC 300

Query: 301  RFAPKRRRRGAPEGGQPYPVLRVAHSAPVGAQLATELSIAEGQEVLFGVFVTGKDGGPGV 360
            RFAPKRRRRGAPEGGQPYPVLRVAHSAPVGAQLATELSIAEGQEVLFGVFVTGKDGGPGV
Sbjct: 301  RFAPKRRRRGAPEGGQPYPVLRVAHSAPVGAQLATELSIAEGQEVLFGVFVTGKDGGPGV 360

Query: 361  GPNSVVCAFPIDLLDTLIDEGVERCCESPVHPGLRRGLDFFQSPSFCPNPPGLEALSPNT 420
            GPNSVVCAFPIDLLDTLIDEGVERCCESPVHPGLRRGLDFFQSPSFCPNPPGLEALSPNT
Sbjct: 361  GPNSVVCAFPIDLLDTLIDEGVERCCESPVHPGLRRGLDFFQSPSFCPNPPGLEALSPNT 420

Query: 421  SCRHFPLLVSSSFSRVDLFNGLLGPVQVTALYVTRLDNVTVAHMGTMDGRILQVELVRSL 480
            SCRHFPLLVSSSFSRVDLFNGLLGPVQVTALYVTRLDNVTVAHMGTMDGRILQVELVRSL
Sbjct: 421  SCRHFPLLVSSSFSRVDLFNGLLGPVQVTALYVTRLDNVTVAHMGTMDGRILQVELVRSL 480

Query: 481  NYLLYVSNFSLGDSGQPVQRDVSRLGDHLLFASGDQVFQVPIQGPGCRHFLTCGRCLRAW 540
            NYLLYVSNFSLGDSGQPVQRDVSRLGDHLLFASGDQVFQVPIQGPGCRHFLTCGRCLRAW
Sbjct: 481  NYLLYVSNFSLGDSGQPVQRDVSRLGDHLLFASGDQVFQVPIQGPGCRHFLTCGRCLRAW 540

Query: 541  HFMGCGWCGNMCGQQKECPGSWQQDHCPPKLTEFHPHSGPLRGSTRLTLCGSNFYLHPSG 600
            HFMGCGWCGNMCGQQKECPGSWQQDHCPPKLTEFHPHSGPLRGSTRLTLCGSNFYLHPSG
Sbjct: 541  HFMGCGWCGNMCGQQKECPGSWQQDHCPPKLTEFHPHSGPLRGSTRLTLCGSNFYLHPSG 600

Query: 601  LVPEGTHQVTVGQSPCRPLPKDSSKLRPVPRKDFVEEFECELEPLGTQAVGPTNVSLTVT 660
            LVPEGTHQVTVGQSPCRPLPKDSSKLRPVPRKDFVEEFECELEPLGTQAVGPTNVSLTVT
Sbjct: 601  LVPEGTHQVTVGQSPCRPLPKDSSKLRPVPRKDFVEEFECELEPLGTQAVGPTNVSLTVT 660

Query: 661  NMPPGKHFRVDGTSVLRGFSFMEPVLIAVQPLFGPRAGGTCLTLEGQSLSVGTSRAVLVN 720
            NMPPGKHFRVDGTSVLRGFSFMEPVLIAVQPLFGPRAGGTCLTLEGQSLSVGTSRAVLVN
Sbjct: 661  NMPPGKHFRVDGTSVLRGFSFMEPVLIAVQPLFGPRAGGTCLTLEGQSLSVGTSRAVLVN 720

Query: 721  GTECLLARVSEGQLLCATPPGATVASVPLSLQVGGAQVPGSWTFQYREDPVVLSISPNCG 780
            GTECLLARVSEGQLLCATPPGATVASVPLSLQVGGAQVPGSWTFQYREDPVVLSISPNCG
Sbjct: 721  GTECLLARVSEGQLLCATPPGATVASVPLSLQVGGAQVPGSWTFQYREDPVVLSISPNCG 780

Query: 781  YINSHITICGQHLTSAWHLVLSFHDGLRAVESRCERQLPEQQLCRLPEYVVRDPQGWVAG 840
            YINSHITICGQHLTSAWHLVLSFHDGLRAVESRCERQLPEQQLCRLPEYVVRDPQGWVAG
Sbjct: 781  YINSHITICGQHLTSAWHLVLSFHDGLRAVESRCERQLPEQQLCRLPEYVVRDPQGWVAG 840

Query: 841  NLSARGDGAAGFTLPGFRFLPPPHPPSANLVPLKPEEHAIKFEYIGLGAVADCVGINVTV 900
            NLSARGDGAAGFTLPGFRFLPPPHPPSANLVPLKPEEHAIKFEYIGLGAVADCVGINVTV
Sbjct: 841  NLSARGDGAAGFTLPGFRFLPPPHPPSANLVPLKPEEHAIKFEYIGLGAVADCVGINVTV 900

Query: 901  GGESCQHEFRGDMVVCPLPPSLQLGQDGAPLQVCVDGECHILGRVVRPGPDGVPQSTLLG 960
            GGESCQHEFRGDMVVCPLPPSLQLGQDGAPLQVCVDGECHILGRVVRPGPDGVPQSTLLG
Sbjct: 901  GGESCQHEFRGDMVVCPLPPSLQLGQDGAPLQVCVDGECHILGRVVRPGPDGVPQSTLLG 960

Query: 961  ILLPLLLLVAALATALVFSYWWRRKQLVLPPNLNDLASLDQTAGATPLPILYSGSDYRSG 1020
            ILLPLLLLVAALATALVFSYWWRRKQLVLPPNLNDLASLDQTAGATPLPILYSGSDYRSG
Sbjct: 961  ILLPLLLLVAALATALVFSYWWRRKQLVLPPNLNDLASLDQTAGATPLPILYSGSDYRSG 1020

Query: 1021 LALPAIDGLDSTTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHERV 1080
            LALPAIDGLDSTTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHERV
Sbjct: 1021 LALPAIDGLDSTTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHERV 1080

Query: 1081 VTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNH 1140
            VTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNH
Sbjct: 1081 VTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNH 1140

Query: 1141 PNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLA 1200
            PNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLA
Sbjct: 1141 PNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLA 1200

Query: 1201 EQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQ 1260
            EQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQ
Sbjct: 1201 EQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQ 1260

Query: 1261 TYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVM 1320
            TYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVM
Sbjct: 1261 TYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVM 1320

Query: 1321 QQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPSTSHEMNVRPEQPQF 1380
            QQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPSTSHEMNVRPEQPQF
Sbjct: 1321 QQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPSTSHEMNVRPEQPQF 1380

Query: 1381 SPMPGNVRRPRPLSEPPRPT 1400
            SPMPGNVRRPRPLSEPPRPT
Sbjct: 1381 SPMPGNVRRPRPLSEPPRPT 1400


>gi|42741655 met proto-oncogene isoform b precursor [Homo sapiens]
          Length = 1390

 Score =  720 bits (1859), Expect = 0.0
 Identities = 482/1406 (34%), Positives = 710/1406 (50%), Gaps = 102/1406 (7%)

Query: 7    LPQSFLLLLLLPAKPAAGEDWQCPRTPYAASRDFDVKYVVPSFSAGGLVQAMVTYEGDRN 66
            L    L+LL    + + GE   C      +  + ++KY +P+F+A   +Q ++ +E    
Sbjct: 7    LAPGILVLLFTLVQRSNGE---CKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHH-- 61

Query: 67   ESAVFVAIRNRLHVLGP-DLKSVQSLATGPAGD-PGCQTCAACGPGPHGPPG---DTDTK 121
               +F+   N ++VL   DL+ V    TGP  + P C  C  C    +   G   D    
Sbjct: 62   ---IFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINM 118

Query: 122  VLVLDPALP-ALVSCGSSLQGRCFLHDLEPQGTAVHLAAPACLFSAHHNRPDDCPDCVAS 180
             LV+D      L+SCGS  +G C  H      TA   +   C+FS     P  CPDCV S
Sbjct: 119  ALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVS 178

Query: 181  PLGTRVTVVEQGQASYFYVASSLDAAVAASFSPRSVSIRRLKADASGFAPGFVA----LS 236
             LG +V    + +   F+V ++++++        S+S+RRLK    GF   F+     + 
Sbjct: 179  ALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFM--FLTDQSYID 236

Query: 237  VLPKHLVSYSIEYVHSFHTGAFVYFLTVQPASVTDDPSALHTRLARLSATEPELGDYREL 296
            VLP+   SY I+YVH+F +  F+YFLTVQ  ++  D    HTR+ R  +    L  Y E+
Sbjct: 237  VLPEFRDSYPIKYVHAFESNNFIYFLTVQRETL--DAQTFHTRIIRFCSINSGLHSYMEM 294

Query: 297  VLDCRFAPKRRRRGAPEGGQPYPVLRVAHSAPVGAQLATELSIAEGQEVLFGVFVTGKDG 356
             L+C    KR++R   +  + + +L+ A+ +  GAQLA ++  +   ++LFGVF   K  
Sbjct: 295  PLECILTEKRKKRSTKK--EVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPD 352

Query: 357  GPGVGPNSVVCAFPI----DLLDTLIDEGVERCCESPVHPGLRRGLDFFQSPSFCPNPPG 412
                   S +CAFPI    D  + ++++   RC +    P      +     +   N  G
Sbjct: 353  SAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFN----RTLLRNSSG 408

Query: 413  LEALSPNTSCRHFPLLVSSSFSRVDLFNGLLGPVQVTALYVTRLDNVTVAHMGTMDGRIL 472
             EA         +    +++  RVDLF G    V +T++      ++T+A++GT +GR +
Sbjct: 409  CEARRDE-----YRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFM 463

Query: 473  QVELVRSLNYLLYVSNFSLGD---SGQPVQRDVSRLGDHLLFASGDQVFQVPIQGPGCRH 529
            QV + RS     +V NF L     S + +         + L  +G ++ ++P+ G GCRH
Sbjct: 464  QVVVSRSGPSTPHV-NFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRH 522

Query: 530  FLTCGRCLRAWHFMGCGWCGNMCGQQKEC-PGSWQQDHCPPKLTEFHPHSGPLRGSTRLT 588
            F +C +CL A  F+ CGWC + C + +EC  G+W Q  C P + +  P+S PL G TRLT
Sbjct: 523  FQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLT 582

Query: 589  LCGSNFYLHPSGLVPEGTHQVTVGQSPCRPLPKDSSKLRPVPRKDFVEEFECELEPLGTQ 648
            +CG +F    +        +V +G   C     +S+          +   +C + P   +
Sbjct: 583  ICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSEST----------MNTLKCTVGPAMNK 632

Query: 649  AVGPTNVSLTVTNMPPGKHFRVDGTSVLRGFSFMEPVLIAVQPLFGPRAGGTCLTLEGQS 708
                 N+S+ ++N          GT+    FS+++PV+ ++ P +GP AGGT LTL G  
Sbjct: 633  HF---NMSIIISNG--------HGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNY 681

Query: 709  LSVGTSRAVLVNGTECLLARVSEGQLLCATPPGATVASVPLSLQVGGAQVPGSWTFQYRE 768
            L+ G SR + + G  C L  VS   L C TP         + L++  A    S  F YRE
Sbjct: 682  LNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETS-IFSYRE 740

Query: 769  DPVVLSISPNCGYIN--SHITICGQHLTSAW--HLVLSFHDGLRAVESRCE-RQLPEQQL 823
            DP+V  I P   +I+  S IT  G++L S     +V++ H+  R     C+ R   E   
Sbjct: 741  DPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIIC 800

Query: 824  CRLPEYVVRDPQGWVAGNLSARGDGAAGFTLPGFRFLPPPHPPSANLVPLKPEEHAIKFE 883
            C  P     + Q  +        DG             P   P    V +      +  E
Sbjct: 801  CTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENV-LE 859

Query: 884  YIGLGAVADCV-GINVTVGGESCQH-EFRGDMVVCPLPPSLQLGQDGAPLQVCVDGECHI 941
              G     + V G  + VG +SC++     + V+C +P  L        ++        +
Sbjct: 860  IKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTV 919

Query: 942  LGRVVRPGPDGVPQSTLLGILLPLLLLVAALATALVFSYWWR-RKQL------------- 987
            LG+V+       P     G++  ++ +  AL   L F  W + RKQ+             
Sbjct: 920  LGKVIVQ-----PDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDAR 974

Query: 988  VLPPNLNDLASLDQTAGATPLPILYSGSDYRSGLALPAIDGLDSTTCVHGASF------- 1040
            V  P+L+ L S    +  T + +     DYR+                    +       
Sbjct: 975  VHTPHLDRLVSARSVSPTTEM-VSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSP 1033

Query: 1041 --SDSEDESCVPLLRKE-SIQLRDLDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVY 1097
              +  + +   PLL+    I L  L+  L+  V+ V+I    ++ H + VIG+GHFG VY
Sbjct: 1034 ILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVY 1093

Query: 1098 HGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLP 1157
            HG  +D    +I CA+KSL+RIT++ +V  FL EG++M+  +HPNVL+L+GI L  EG P
Sbjct: 1094 HGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSP 1153

Query: 1158 HVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLD 1217
             V+LPYM HGDL  FIR+   NPTVKDLI FGLQVA+GM+YLA +KFVHRDLAARNCMLD
Sbjct: 1154 LVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD 1213

Query: 1218 ESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLL 1277
            E FTVKVADFGLARD+ D+EYYSV     A+LPVKWMALESLQT +FTTKSDVWSFGVLL
Sbjct: 1214 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLL 1273

Query: 1278 WELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVL 1337
            WEL+TRGAPPY  ++ FD+T +L QGRRL QPEYCPD LY+VM +CW     +RP+F  L
Sbjct: 1274 WELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSEL 1333

Query: 1338 VGEVEQIVSALLGDHYVQLPATYMNL 1363
            V  +  I S  +G+HYV + ATY+N+
Sbjct: 1334 VSRISAIFSTFIGEHYVHVNATYVNV 1359


>gi|188595716 met proto-oncogene isoform a precursor [Homo sapiens]
          Length = 1408

 Score =  713 bits (1841), Expect = 0.0
 Identities = 482/1424 (33%), Positives = 710/1424 (49%), Gaps = 120/1424 (8%)

Query: 7    LPQSFLLLLLLPAKPAAGEDWQCPRTPYAASRDFDVKYVVPSFSAGGLVQAMVTYEGDRN 66
            L    L+LL    + + GE   C      +  + ++KY +P+F+A   +Q ++ +E    
Sbjct: 7    LAPGILVLLFTLVQRSNGE---CKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHH-- 61

Query: 67   ESAVFVAIRNRLHVLGP-DLKSVQSLATGPAGD-PGCQTCAACGPGPHGPPG---DTDTK 121
               +F+   N ++VL   DL+ V    TGP  + P C  C  C    +   G   D    
Sbjct: 62   ---IFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINM 118

Query: 122  VLVLDPALP-ALVSCGSSLQGRCFLHDLEPQGTAVHLAAPACLFSAHHNRPDDCPDCVAS 180
             LV+D      L+SCGS  +G C  H      TA   +   C+FS     P  CPDCV S
Sbjct: 119  ALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVS 178

Query: 181  PLGTRVTVVEQGQASYFYVASSLDAAVAASFSPRSVSIRRLKADASGFAPGFVA----LS 236
             LG +V    + +   F+V ++++++        S+S+RRLK    GF   F+     + 
Sbjct: 179  ALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFM--FLTDQSYID 236

Query: 237  VLPKHLVSYSIEYVHSFHTGAFVYFLTVQPASVTDDPSALHTRLARLSATEPELGDYREL 296
            VLP+   SY I+YVH+F +  F+YFLTVQ  ++  D    HTR+ R  +    L  Y E+
Sbjct: 237  VLPEFRDSYPIKYVHAFESNNFIYFLTVQRETL--DAQTFHTRIIRFCSINSGLHSYMEM 294

Query: 297  VLDCRFAPKRRRRGAPEGGQPYPVLRVAHSAPVGAQLATELSIAEGQEVLFGVFVTGKDG 356
             L+C    KR++R   +  + + +L+ A+ +  GAQLA ++  +   ++LFGVF   K  
Sbjct: 295  PLECILTEKRKKRSTKK--EVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPD 352

Query: 357  GPGVGPNSVVCAFPI----DLLDTLIDEGVERCCESPVHPGLRRGLDFFQSPSFCPNPPG 412
                   S +CAFPI    D  + ++++   RC +    P      +     +   N  G
Sbjct: 353  SAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFN----RTLLRNSSG 408

Query: 413  LEALSPNTSCRHFPLLVSSSFSRVDLFNGLLGPVQVTALYVTRLDNVTVAHMGTMDGRIL 472
             EA         +    +++  RVDLF G    V +T++      ++T+A++GT +GR +
Sbjct: 409  CEARRDE-----YRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFM 463

Query: 473  QVELVRSLNYLLYVSNFSLGD---SGQPVQRDVSRLGDHLLFASGDQVFQVPIQGPGCRH 529
            QV + RS     +V NF L     S + +         + L  +G ++ ++P+ G GCRH
Sbjct: 464  QVVVSRSGPSTPHV-NFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRH 522

Query: 530  FLTCGRCLRAWHFMGCGWCGNMCGQQKEC-PGSWQQDHCPPKLTEFHPHSGPLRGSTRLT 588
            F +C +CL A  F+ CGWC + C + +EC  G+W Q  C P + +  P+S PL G TRLT
Sbjct: 523  FQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLT 582

Query: 589  LCGSNFYLHPSGLVPEGTHQVTVGQSPCRPLPKDSSKLRPVPRKDFVEEFECELEPLGTQ 648
            +CG +F    +        +V +G   C     +S+          +   +C + P   +
Sbjct: 583  ICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSEST----------MNTLKCTVGPAMNK 632

Query: 649  AVGPTNVSLTVTNMPPGKHFRVDGTSVLRGFSFMEPVLIAVQPLFGPRAGGTCLTLEGQS 708
                 N+S+ ++N          GT+    FS+++PV+ ++ P +GP AGGT LTL G  
Sbjct: 633  HF---NMSIIISNG--------HGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNY 681

Query: 709  LSVGTSRAVLVNGTECLLARVSEGQLLCATPPGATVASVPLSLQVGGAQVPGSWTFQYRE 768
            L+ G SR + + G  C L  VS   L C TP         + L++  A    S  F YRE
Sbjct: 682  LNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETS-IFSYRE 740

Query: 769  DPVVLSISPNCGYIN--------------------SHITICGQHLTSAW--HLVLSFHDG 806
            DP+V  I P   +I+                    S IT  G++L S     +V++ H+ 
Sbjct: 741  DPIVYEIHPTKSFISTWWKEPLNIVSFLFCFASGGSTITGVGKNLNSVSVPRMVINVHEA 800

Query: 807  LRAVESRCE-RQLPEQQLCRLPEYVVRDPQGWVAGNLSARGDGAAGFTLPGFRFLPPPHP 865
             R     C+ R   E   C  P     + Q  +        DG             P   
Sbjct: 801  GRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFK 860

Query: 866  PSANLVPLKPEEHAIKFEYIGLGAVADCV-GINVTVGGESCQH-EFRGDMVVCPLPPSLQ 923
            P    V +      +  E  G     + V G  + VG +SC++     + V+C +P  L 
Sbjct: 861  PFEKPVMISMGNENV-LEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLL 919

Query: 924  LGQDGAPLQVCVDGECHILGRVVRPGPDGVPQSTLLGILLPLLLLVAALATALVFSYWWR 983
                   ++        +LG+V+       P     G++  ++ +  AL   L F  W +
Sbjct: 920  KLNSELNIEWKQAISSTVLGKVIVQ-----PDQNFTGLIAGVVSISTALLLLLGFFLWLK 974

Query: 984  -RKQL-------------VLPPNLNDLASLDQTAGATPLPILYSGSDYRSGLALPAIDGL 1029
             RKQ+             V  P+L+ L S    +  T + +     DYR+          
Sbjct: 975  KRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEM-VSNESVDYRATFPEDQFPNS 1033

Query: 1030 DSTTCVHGASF---------SDSEDESCVPLLRKE-SIQLRDLDSALLAEVKDVLIPHER 1079
                      +         +  + +   PLL+    I L  L+  L+  V+ V+I    
Sbjct: 1034 SQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSS 1093

Query: 1080 VVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLN 1139
            ++ H + VIG+GHFG VYHG  +D    +I CA+KSL+RIT++ +V  FL EG++M+  +
Sbjct: 1094 LIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFS 1153

Query: 1140 HPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYL 1199
            HPNVL+L+GI L  EG P V+LPYM HGDL  FIR+   NPTVKDLI FGLQVA+GM+YL
Sbjct: 1154 HPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYL 1213

Query: 1200 AEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESL 1259
            A +KFVHRDLAARNCMLDE FTVKVADFGLARD+ D+EYYSV     A+LPVKWMALESL
Sbjct: 1214 ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESL 1273

Query: 1260 QTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQV 1319
            QT +FTTKSDVWSFGVLLWEL+TRGAPPY  ++ FD+T +L QGRRL QPEYCPD LY+V
Sbjct: 1274 QTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEV 1333

Query: 1320 MQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNL 1363
            M +CW     +RP+F  LV  +  I S  +G+HYV + ATY+N+
Sbjct: 1334 MLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNV 1377


>gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens]
          Length = 890

 Score =  228 bits (580), Expect = 4e-59
 Identities = 125/298 (41%), Positives = 181/298 (60%), Gaps = 15/298 (5%)

Query: 1062 LDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSR-IT 1120
            +   L  +++DVLIP ++      R++GKG FG V   +   +  + ++ A+K L   I 
Sbjct: 500  ISDELKEKLEDVLIPEQQFTL--GRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADII 557

Query: 1121 EMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEG-----LPHVLLPYMCHGDLLQFIRS 1175
                +E FLRE   M+  +HP+V  L+G+ L         +P V+LP+M HGDL  F+ +
Sbjct: 558  ASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLA 617

Query: 1176 PQ--RNP---TVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLA 1230
             +   NP    ++ LI F + +A GMEYL+ + F+HRDLAARNCML E  TV VADFGL+
Sbjct: 618  SRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLS 677

Query: 1231 RDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRH 1290
            R I   +YY  +Q   ++LPVKW+ALESL    +T +SDVW+FGV +WE++TRG  PY  
Sbjct: 678  RKIYSGDYY--RQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAG 735

Query: 1291 IDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSAL 1348
            I+  ++ ++L  G RL QP  C + +Y +M QCW ADP  RP+F  L  E+E I+  L
Sbjct: 736  IENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQL 793


>gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]
          Length = 999

 Score =  226 bits (575), Expect = 2e-58
 Identities = 124/332 (37%), Positives = 199/332 (59%), Gaps = 25/332 (7%)

Query: 1037 GASFSDSEDESCVPLLRKESIQLRDLDSALLA---------EVKDVLIPHERVVTHSDRV 1087
            G +F++ + E  V  + K+S   R ++  L +         +++DV+I    ++    ++
Sbjct: 535  GNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLIL--GKI 592

Query: 1088 IGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQ-QVEAFLREGLLMRGLNHPNVLAL 1146
            +G+G FG V  G    +    ++ A+K++      Q ++E FL E   M+  +HPNV+ L
Sbjct: 593  LGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRL 652

Query: 1147 IGIMLP--PEGLPH--VLLPYMCHGDLLQFI------RSPQRNPTVKDLISFGLQVARGM 1196
            +G+ +    +G+P   V+LP+M +GDL  ++        P+  P ++ L+ F + +A GM
Sbjct: 653  LGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIP-LQTLLKFMVDIALGM 711

Query: 1197 EYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMAL 1256
            EYL+ + F+HRDLAARNCML +  TV VADFGL++ I   +YY  +Q R A++PVKW+A+
Sbjct: 712  EYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYY--RQGRIAKMPVKWIAI 769

Query: 1257 ESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSL 1316
            ESL    +T+KSDVW+FGV +WE+ TRG  PY  +   ++  +L  G RL QPE C D L
Sbjct: 770  ESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDEL 829

Query: 1317 YQVMQQCWEADPAVRPTFRVLVGEVEQIVSAL 1348
            Y++M  CW  DP  RPTF VL  ++E+++ +L
Sbjct: 830  YEIMYSCWRTDPLDRPTFSVLRLQLEKLLESL 861


>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
          Length = 885

 Score =  222 bits (566), Expect = 2e-57
 Identities = 121/299 (40%), Positives = 185/299 (61%), Gaps = 18/299 (6%)

Query: 1062 LDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLS-RIT 1120
            +   L  +++DV++   +V     + +G+G FG V  G+ ++Q  + ++ A+K++   I 
Sbjct: 509  ISEELKEKLRDVMVDRHKVAL--GKTLGEGEFGAVMEGQ-LNQDDSILKVAVKTMKIAIC 565

Query: 1121 EMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEG-----LPHVLLPYMCHGDLLQFIR- 1174
               ++E FL E + M+  +HPNV+ LIG+            P V+LP+M HGDL  F+  
Sbjct: 566  TRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLY 625

Query: 1175 -----SPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGL 1229
                  P   PT + L+ F   +A GMEYL+ ++F+HRDLAARNCML+E+ +V VADFGL
Sbjct: 626  SRLGDQPVYLPT-QMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGL 684

Query: 1230 ARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYR 1289
            ++ I + +YY  +Q R A++PVKW+A+ESL    +T+KSDVWSFGV +WE+ TRG  PY 
Sbjct: 685  SKKIYNGDYY--RQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYP 742

Query: 1290 HIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSAL 1348
             ++  ++  +L QG RL QP  C D LY +M +CWE +P  RP+F  L  ++E  + AL
Sbjct: 743  GVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKAL 801


>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
          Length = 894

 Score =  222 bits (566), Expect = 2e-57
 Identities = 121/299 (40%), Positives = 185/299 (61%), Gaps = 18/299 (6%)

Query: 1062 LDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLS-RIT 1120
            +   L  +++DV++   +V     + +G+G FG V  G+ ++Q  + ++ A+K++   I 
Sbjct: 518  ISEELKEKLRDVMVDRHKVAL--GKTLGEGEFGAVMEGQ-LNQDDSILKVAVKTMKIAIC 574

Query: 1121 EMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEG-----LPHVLLPYMCHGDLLQFIR- 1174
               ++E FL E + M+  +HPNV+ LIG+            P V+LP+M HGDL  F+  
Sbjct: 575  TRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLY 634

Query: 1175 -----SPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGL 1229
                  P   PT + L+ F   +A GMEYL+ ++F+HRDLAARNCML+E+ +V VADFGL
Sbjct: 635  SRLGDQPVYLPT-QMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGL 693

Query: 1230 ARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYR 1289
            ++ I + +YY  +Q R A++PVKW+A+ESL    +T+KSDVWSFGV +WE+ TRG  PY 
Sbjct: 694  SKKIYNGDYY--RQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYP 751

Query: 1290 HIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSAL 1348
             ++  ++  +L QG RL QP  C D LY +M +CWE +P  RP+F  L  ++E  + AL
Sbjct: 752  GVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKAL 810


>gi|54607018 RYK receptor-like tyrosine kinase isoform 2 [Homo
            sapiens]
          Length = 607

 Score =  214 bits (546), Expect = 4e-55
 Identities = 129/349 (36%), Positives = 193/349 (55%), Gaps = 23/349 (6%)

Query: 1013 SGSDYRSGLALPAIDGLDSTTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAE--- 1069
            S S    GL+ P+     +T  +   + +++   +  P LR   I+  DL S  L E   
Sbjct: 265  SASSSSQGLSQPSTQ---TTQYLRADTPNNATPITSYPTLR---IEKNDLRSVTLLEAKG 318

Query: 1070 -VKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQ--NRIQCAIKSLSRITEMQQVE 1126
             VKD+ I  ER+      V+ +G FG ++HG  ID+       Q  +K++       QV 
Sbjct: 319  KVKDIAISRERITLKD--VLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVT 376

Query: 1127 AFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQ----RNPTV 1182
              L E   +RGL+H N+L +  + +     P V+LPYM  G+L  F+R  +     NP  
Sbjct: 377  MMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQA 436

Query: 1183 ---KDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYY 1239
               +DL+   +Q+A GM YLA ++ +H+DLAARNC++D++  VK+ D  L+RD+   +Y+
Sbjct: 437  ISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYH 496

Query: 1240 SVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHF 1299
             +  + +   PV+WMALESL    F++ SDVW+FGV LWEL+T G  PY  IDPF++  +
Sbjct: 497  CLGDNENR--PVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAY 554

Query: 1300 LAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSAL 1348
            L  G R+ QP  CPD L+ VM  CW  DP  RP F+ LV  + +  +AL
Sbjct: 555  LKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAAL 603


>gi|54607020 RYK receptor-like tyrosine kinase isoform 1 [Homo
            sapiens]
          Length = 610

 Score =  213 bits (543), Expect = 8e-55
 Identities = 123/312 (39%), Positives = 178/312 (57%), Gaps = 20/312 (6%)

Query: 1050 PLLRKESIQLRDLDSALLAE----VKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQA 1105
            P LR   I+  DL S  L E    VKD+ I  ER+      V+ +G FG ++HG  ID+ 
Sbjct: 302  PTLR---IEKNDLRSVTLLEAKGKVKDIAISRERITLKD--VLQEGTFGRIFHGILIDEK 356

Query: 1106 Q--NRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPY 1163
                  Q  +K++       QV   L E   +RGL+H N+L +  + +     P V+LPY
Sbjct: 357  DPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPY 416

Query: 1164 MCHGDLLQFIRSPQ----RNPTV---KDLISFGLQVARGMEYLAEQKFVHRDLAARNCML 1216
            M  G+L  F+R  +     NP     +DL+   +Q+A GM YLA ++ +H+DLAARNC++
Sbjct: 417  MNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVI 476

Query: 1217 DESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVL 1276
            D++  VK+ D  L+RD+   +Y+ +  + +   PV+WMALESL    F++ SDVW+FGV 
Sbjct: 477  DDTLQVKITDNALSRDLFPMDYHCLGDNENR--PVRWMALESLVNNEFSSASDVWAFGVT 534

Query: 1277 LWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRV 1336
            LWEL+T G  PY  IDPF++  +L  G R+ QP  CPD L+ VM  CW  DP  RP F+ 
Sbjct: 535  LWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQ 594

Query: 1337 LVGEVEQIVSAL 1348
            LV  + +  +AL
Sbjct: 595  LVQCLTEFHAAL 606


>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
            [Homo sapiens]
          Length = 694

 Score =  207 bits (527), Expect = 6e-53
 Identities = 131/366 (35%), Positives = 199/366 (54%), Gaps = 33/366 (9%)

Query: 1027 DGLDSTTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHE------RV 1080
            DG    T +  +  S++   S  PL+R    +L   +   LA V ++ +P +      R 
Sbjct: 301  DGTPYVTVLKVSLESNASMSSNTPLVR--IARLSSGEGPTLANVSELELPADPKWELSRA 358

Query: 1081 VTHSDRVIGKGHFGVVYHGEYI----DQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMR 1136
                 + +G+G FG V   E I    D+A   +  A+K L      + +   + E  +M+
Sbjct: 359  RLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMK 418

Query: 1137 GLN-HPNVLALIGIMLPPEGLP-HVLLPYMCHGDLLQFIRS---------------PQRN 1179
             +  H N++ L+G     +G P +VL+ Y   G+L +F+R+               P+  
Sbjct: 419  MIGKHKNIINLLGACT--QGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQ 476

Query: 1180 PTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYY 1239
             T KDL+S   QVARGMEYLA QK +HRDLAARN ++ E   +K+ADFGLARD+ + +YY
Sbjct: 477  LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYY 536

Query: 1240 SVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHF 1299
              ++  + RLPVKWMA E+L    +T +SDVWSFGVLLWE+ T G  PY  I   +L   
Sbjct: 537  --KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKL 594

Query: 1300 LAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPAT 1359
            L +G R+ +P  C   LY +M++CW A P+ RPTF+ LV +++++++    D Y+ L A 
Sbjct: 595  LKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAP 654

Query: 1360 YMNLGP 1365
            +    P
Sbjct: 655  FEQYSP 660


>gi|254028242 fibroblast growth factor receptor 3 isoform 3 precursor
            [Homo sapiens]
          Length = 808

 Score =  206 bits (524), Expect = 1e-52
 Identities = 132/376 (35%), Positives = 201/376 (53%), Gaps = 34/376 (9%)

Query: 1018 RSGLALPAIDGLDSTTCVHGASF-SDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIP 1076
            + GL  P +  +         S  S++   S  PL+R    +L   +   LA V ++ +P
Sbjct: 405  KKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR--IARLSSGEGPTLANVSELELP 462

Query: 1077 HE------RVVTHSDRVIGKGHFGVVYHGEYI----DQAQNRIQCAIKSLSRITEMQQVE 1126
             +      R      + +G+G FG V   E I    D+A   +  A+K L      + + 
Sbjct: 463  ADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLS 522

Query: 1127 AFLREGLLMRGLN-HPNVLALIGIMLPPEGLP-HVLLPYMCHGDLLQFIRS--------- 1175
              + E  +M+ +  H N++ L+G     +G P +VL+ Y   G+L +F+R+         
Sbjct: 523  DLVSEMEMMKMIGKHKNIINLLGACT--QGGPLYVLVEYAAKGNLREFLRARRPPGLDYS 580

Query: 1176 ------PQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGL 1229
                  P+   T KDL+S   QVARGMEYLA QK +HRDLAARN ++ E   +K+ADFGL
Sbjct: 581  FDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGL 640

Query: 1230 ARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYR 1289
            ARD+ + +YY  ++  + RLPVKWMA E+L    +T +SDVWSFGVLLWE+ T G  PY 
Sbjct: 641  ARDVHNLDYY--KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYP 698

Query: 1290 HIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALL 1349
             I   +L   L +G R+ +P  C   LY +M++CW A P+ RPTF+ LV +++++++   
Sbjct: 699  GIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTS 758

Query: 1350 GDHYVQLPATYMNLGP 1365
             D Y+ L A +    P
Sbjct: 759  TDEYLDLSAPFEQYSP 774


>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
            [Homo sapiens]
          Length = 806

 Score =  206 bits (524), Expect = 1e-52
 Identities = 132/376 (35%), Positives = 201/376 (53%), Gaps = 34/376 (9%)

Query: 1018 RSGLALPAIDGLDSTTCVHGASF-SDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIP 1076
            + GL  P +  +         S  S++   S  PL+R    +L   +   LA V ++ +P
Sbjct: 403  KKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR--IARLSSGEGPTLANVSELELP 460

Query: 1077 HE------RVVTHSDRVIGKGHFGVVYHGEYI----DQAQNRIQCAIKSLSRITEMQQVE 1126
             +      R      + +G+G FG V   E I    D+A   +  A+K L      + + 
Sbjct: 461  ADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLS 520

Query: 1127 AFLREGLLMRGLN-HPNVLALIGIMLPPEGLP-HVLLPYMCHGDLLQFIRS--------- 1175
              + E  +M+ +  H N++ L+G     +G P +VL+ Y   G+L +F+R+         
Sbjct: 521  DLVSEMEMMKMIGKHKNIINLLGACT--QGGPLYVLVEYAAKGNLREFLRARRPPGLDYS 578

Query: 1176 ------PQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGL 1229
                  P+   T KDL+S   QVARGMEYLA QK +HRDLAARN ++ E   +K+ADFGL
Sbjct: 579  FDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGL 638

Query: 1230 ARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYR 1289
            ARD+ + +YY  ++  + RLPVKWMA E+L    +T +SDVWSFGVLLWE+ T G  PY 
Sbjct: 639  ARDVHNLDYY--KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYP 696

Query: 1290 HIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALL 1349
             I   +L   L +G R+ +P  C   LY +M++CW A P+ RPTF+ LV +++++++   
Sbjct: 697  GIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTS 756

Query: 1350 GDHYVQLPATYMNLGP 1365
             D Y+ L A +    P
Sbjct: 757  TDEYLDLSAPFEQYSP 772


>gi|222144239 fibroblast growth factor receptor 2 isoform 7 precursor
            [Homo sapiens]
          Length = 705

 Score =  204 bits (518), Expect = 6e-52
 Identities = 126/366 (34%), Positives = 198/366 (54%), Gaps = 29/366 (7%)

Query: 1027 DGLDSTTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHE------RV 1080
            DGL     +  ++ S S   S  PL+R  +      D+ +LA V +  +P +      R 
Sbjct: 304  DGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 363

Query: 1081 VTHSDRVIGKGHFGVVYHGEYI----DQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMR 1136
                 + +G+G FG V   E +    D+ +  +  A+K L      + +   + E  +M+
Sbjct: 364  KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 423

Query: 1137 GLN-HPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRS---------------PQRNP 1180
             +  H N++ L+G     +G  +V++ Y   G+L +++R+               P+   
Sbjct: 424  MIGKHKNIINLLGACTQ-DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 482

Query: 1181 TVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYS 1240
            T KDL+S   Q+ARGMEYLA QK +HRDLAARN ++ E+  +K+ADFGLARDI + +YY 
Sbjct: 483  TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY- 541

Query: 1241 VQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFL 1300
             ++  + RLPVKWMA E+L    +T +SDVWSFGVL+WE+ T G  PY  I   +L   L
Sbjct: 542  -KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL 600

Query: 1301 AQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATY 1360
             +G R+ +P  C + LY +M+ CW A P+ RPTF+ LV ++++I++    + Y+ L    
Sbjct: 601  KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPL 660

Query: 1361 MNLGPS 1366
                PS
Sbjct: 661  EQYSPS 666


>gi|222144241 fibroblast growth factor receptor 2 isoform 8 precursor
            [Homo sapiens]
          Length = 704

 Score =  201 bits (512), Expect = 3e-51
 Identities = 123/352 (34%), Positives = 192/352 (54%), Gaps = 29/352 (8%)

Query: 1041 SDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHE------RVVTHSDRVIGKGHFG 1094
            S S   S  PL+R  +      D+ +LA V +  +P +      R      + +G+G FG
Sbjct: 317  SSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFG 376

Query: 1095 VVYHGEYI----DQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLN-HPNVLALIGI 1149
             V   E +    D+ +  +  A+K L      + +   + E  +M+ +  H N++ L+G 
Sbjct: 377  QVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGA 436

Query: 1150 MLPPEGLPHVLLPYMCHGDLLQFIRS---------------PQRNPTVKDLISFGLQVAR 1194
                +G  +V++ Y   G+L +++R+               P+   T KDL+S   Q+AR
Sbjct: 437  CTQ-DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLAR 495

Query: 1195 GMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWM 1254
            GMEYLA QK +HRDLAARN ++ E+  +K+ADFGLARDI + +YY  ++  + RLPVKWM
Sbjct: 496  GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY--KKTTNGRLPVKWM 553

Query: 1255 ALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPD 1314
            A E+L    +T +SDVWSFGVL+WE+ T G  PY  I   +L   L +G R+ +P  C +
Sbjct: 554  APEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTN 613

Query: 1315 SLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPS 1366
             LY +M+ CW A P+ RPTF+ LV ++++I++    + Y+ L        PS
Sbjct: 614  ELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPS 665


>gi|222144237 fibroblast growth factor receptor 2 isoform 6 precursor
            [Homo sapiens]
          Length = 706

 Score =  201 bits (512), Expect = 3e-51
 Identities = 123/352 (34%), Positives = 192/352 (54%), Gaps = 29/352 (8%)

Query: 1041 SDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHE------RVVTHSDRVIGKGHFG 1094
            S S   S  PL+R  +      D+ +LA V +  +P +      R      + +G+G FG
Sbjct: 319  SSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFG 378

Query: 1095 VVYHGEYI----DQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLN-HPNVLALIGI 1149
             V   E +    D+ +  +  A+K L      + +   + E  +M+ +  H N++ L+G 
Sbjct: 379  QVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGA 438

Query: 1150 MLPPEGLPHVLLPYMCHGDLLQFIRS---------------PQRNPTVKDLISFGLQVAR 1194
                +G  +V++ Y   G+L +++R+               P+   T KDL+S   Q+AR
Sbjct: 439  CTQ-DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLAR 497

Query: 1195 GMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWM 1254
            GMEYLA QK +HRDLAARN ++ E+  +K+ADFGLARDI + +YY  ++  + RLPVKWM
Sbjct: 498  GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY--KKTTNGRLPVKWM 555

Query: 1255 ALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPD 1314
            A E+L    +T +SDVWSFGVL+WE+ T G  PY  I   +L   L +G R+ +P  C +
Sbjct: 556  APEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTN 615

Query: 1315 SLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPS 1366
             LY +M+ CW A P+ RPTF+ LV ++++I++    + Y+ L        PS
Sbjct: 616  ELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPS 667


>gi|222144233 fibroblast growth factor receptor 2 isoform 4 precursor
            [Homo sapiens]
          Length = 709

 Score =  201 bits (512), Expect = 3e-51
 Identities = 123/352 (34%), Positives = 192/352 (54%), Gaps = 29/352 (8%)

Query: 1041 SDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHE------RVVTHSDRVIGKGHFG 1094
            S S   S  PL+R  +      D+ +LA V +  +P +      R      + +G+G FG
Sbjct: 322  SSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFG 381

Query: 1095 VVYHGEYI----DQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLN-HPNVLALIGI 1149
             V   E +    D+ +  +  A+K L      + +   + E  +M+ +  H N++ L+G 
Sbjct: 382  QVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGA 441

Query: 1150 MLPPEGLPHVLLPYMCHGDLLQFIRS---------------PQRNPTVKDLISFGLQVAR 1194
                +G  +V++ Y   G+L +++R+               P+   T KDL+S   Q+AR
Sbjct: 442  CTQ-DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLAR 500

Query: 1195 GMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWM 1254
            GMEYLA QK +HRDLAARN ++ E+  +K+ADFGLARDI + +YY  ++  + RLPVKWM
Sbjct: 501  GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY--KKTTNGRLPVKWM 558

Query: 1255 ALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPD 1314
            A E+L    +T +SDVWSFGVL+WE+ T G  PY  I   +L   L +G R+ +P  C +
Sbjct: 559  APEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTN 618

Query: 1315 SLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPS 1366
             LY +M+ CW A P+ RPTF+ LV ++++I++    + Y+ L        PS
Sbjct: 619  ELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPS 670


>gi|221316639 fibroblast growth factor receptor 2 isoform 1 precursor
            [Homo sapiens]
          Length = 821

 Score =  201 bits (512), Expect = 3e-51
 Identities = 123/352 (34%), Positives = 192/352 (54%), Gaps = 29/352 (8%)

Query: 1041 SDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHE------RVVTHSDRVIGKGHFG 1094
            S S   S  PL+R  +      D+ +LA V +  +P +      R      + +G+G FG
Sbjct: 434  SSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFG 493

Query: 1095 VVYHGEYI----DQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLN-HPNVLALIGI 1149
             V   E +    D+ +  +  A+K L      + +   + E  +M+ +  H N++ L+G 
Sbjct: 494  QVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGA 553

Query: 1150 MLPPEGLPHVLLPYMCHGDLLQFIRS---------------PQRNPTVKDLISFGLQVAR 1194
                +G  +V++ Y   G+L +++R+               P+   T KDL+S   Q+AR
Sbjct: 554  CTQ-DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLAR 612

Query: 1195 GMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWM 1254
            GMEYLA QK +HRDLAARN ++ E+  +K+ADFGLARDI + +YY  ++  + RLPVKWM
Sbjct: 613  GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY--KKTTNGRLPVKWM 670

Query: 1255 ALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPD 1314
            A E+L    +T +SDVWSFGVL+WE+ T G  PY  I   +L   L +G R+ +P  C +
Sbjct: 671  APEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTN 730

Query: 1315 SLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPS 1366
             LY +M+ CW A P+ RPTF+ LV ++++I++    + Y+ L        PS
Sbjct: 731  ELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPS 782


>gi|221316638 fibroblast growth factor receptor 2 isoform 2 precursor
            [Homo sapiens]
          Length = 822

 Score =  201 bits (512), Expect = 3e-51
 Identities = 123/352 (34%), Positives = 192/352 (54%), Gaps = 29/352 (8%)

Query: 1041 SDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHE------RVVTHSDRVIGKGHFG 1094
            S S   S  PL+R  +      D+ +LA V +  +P +      R      + +G+G FG
Sbjct: 435  SSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFG 494

Query: 1095 VVYHGEYI----DQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLN-HPNVLALIGI 1149
             V   E +    D+ +  +  A+K L      + +   + E  +M+ +  H N++ L+G 
Sbjct: 495  QVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGA 554

Query: 1150 MLPPEGLPHVLLPYMCHGDLLQFIRS---------------PQRNPTVKDLISFGLQVAR 1194
                +G  +V++ Y   G+L +++R+               P+   T KDL+S   Q+AR
Sbjct: 555  CTQ-DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLAR 613

Query: 1195 GMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWM 1254
            GMEYLA QK +HRDLAARN ++ E+  +K+ADFGLARDI + +YY  ++  + RLPVKWM
Sbjct: 614  GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY--KKTTNGRLPVKWM 671

Query: 1255 ALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPD 1314
            A E+L    +T +SDVWSFGVL+WE+ T G  PY  I   +L   L +G R+ +P  C +
Sbjct: 672  APEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTN 731

Query: 1315 SLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPS 1366
             LY +M+ CW A P+ RPTF+ LV ++++I++    + Y+ L        PS
Sbjct: 732  ELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPS 783


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
            sapiens]
          Length = 1367

 Score =  198 bits (503), Expect = 3e-50
 Identities = 118/330 (35%), Positives = 187/330 (56%), Gaps = 27/330 (8%)

Query: 1072 DVLIPHERVVTHS----DRVIGKGHFGVVYHGE----YIDQAQNRIQCAIKSLSRITEMQ 1123
            DV +P E  V        R +G+G FG+VY G       D+ + R+  AIK+++    M+
Sbjct: 985  DVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRV--AIKTVNEAASMR 1042

Query: 1124 QVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPH-VLLPYMCHGDLLQFIRS--PQRN- 1179
            +   FL E  +M+  N  +V+ L+G++   +G P  V++  M  GDL  ++RS  P+   
Sbjct: 1043 ERIEFLNEASVMKEFNCHHVVRLLGVV--SQGQPTLVIMELMTRGDLKSYLRSLRPEMEN 1100

Query: 1180 ------PTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDI 1233
                  P++  +I    ++A GM YL   KFVHRDLAARNCM+ E FTVK+ DFG+ RDI
Sbjct: 1101 NPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI 1160

Query: 1234 LDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDP 1293
             + +YY  ++     LPV+WM+ ESL+   FTT SDVWSFGV+LWE+ T    PY+ +  
Sbjct: 1161 YETDYY--RKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSN 1218

Query: 1294 FDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHY 1353
              +  F+ +G  L +P+ CPD L+++M+ CW+ +P +RP+F  ++  +++ +    G   
Sbjct: 1219 EQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEP--GFRE 1276

Query: 1354 VQLPATYMNLGPSTSHEMNVRPEQPQFSPM 1383
            V    +  N  P    E+++ PE  +  P+
Sbjct: 1277 VSFYYSEENKLPE-PEELDLEPENMESVPL 1305


>gi|222144244 fibroblast growth factor receptor 2 isoform 9 precursor
            [Homo sapiens]
          Length = 680

 Score =  196 bits (497), Expect = 2e-49
 Identities = 119/332 (35%), Positives = 186/332 (56%), Gaps = 29/332 (8%)

Query: 1041 SDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHE------RVVTHSDRVIGKGHFG 1094
            S S   S  PL+R  +      D+ +LA V +  +P +      R      + +G+G FG
Sbjct: 346  SSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFG 405

Query: 1095 VVYHGEYI----DQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLN-HPNVLALIGI 1149
             V   E +    D+ +  +  A+K L      + +   + E  +M+ +  H N++ L+G 
Sbjct: 406  QVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGA 465

Query: 1150 MLPPEGLPHVLLPYMCHGDLLQFIRS---------------PQRNPTVKDLISFGLQVAR 1194
                +G  +V++ Y   G+L +++R+               P+   T KDL+S   Q+AR
Sbjct: 466  CTQ-DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLAR 524

Query: 1195 GMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWM 1254
            GMEYLA QK +HRDLAARN ++ E+  +K+ADFGLARDI + +YY  ++  + RLPVKWM
Sbjct: 525  GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY--KKTTNGRLPVKWM 582

Query: 1255 ALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPD 1314
            A E+L    +T +SDVWSFGVL+WE+ T G  PY  I   +L   L +G R+ +P  C +
Sbjct: 583  APEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTN 642

Query: 1315 SLYQVMQQCWEADPAVRPTFRVLVGEVEQIVS 1346
             LY +M+ CW A P+ RPTF+ LV ++++I++
Sbjct: 643  ELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT 674


>gi|222144231 fibroblast growth factor receptor 2 isoform 3 precursor
            [Homo sapiens]
          Length = 769

 Score =  196 bits (497), Expect = 2e-49
 Identities = 119/332 (35%), Positives = 186/332 (56%), Gaps = 29/332 (8%)

Query: 1041 SDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHE------RVVTHSDRVIGKGHFG 1094
            S S   S  PL+R  +      D+ +LA V +  +P +      R      + +G+G FG
Sbjct: 435  SSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFG 494

Query: 1095 VVYHGEYI----DQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLN-HPNVLALIGI 1149
             V   E +    D+ +  +  A+K L      + +   + E  +M+ +  H N++ L+G 
Sbjct: 495  QVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGA 554

Query: 1150 MLPPEGLPHVLLPYMCHGDLLQFIRS---------------PQRNPTVKDLISFGLQVAR 1194
                +G  +V++ Y   G+L +++R+               P+   T KDL+S   Q+AR
Sbjct: 555  CTQ-DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLAR 613

Query: 1195 GMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWM 1254
            GMEYLA QK +HRDLAARN ++ E+  +K+ADFGLARDI + +YY  ++  + RLPVKWM
Sbjct: 614  GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY--KKTTNGRLPVKWM 671

Query: 1255 ALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPD 1314
            A E+L    +T +SDVWSFGVL+WE+ T G  PY  I   +L   L +G R+ +P  C +
Sbjct: 672  APEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTN 731

Query: 1315 SLYQVMQQCWEADPAVRPTFRVLVGEVEQIVS 1346
             LY +M+ CW A P+ RPTF+ LV ++++I++
Sbjct: 732  ELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT 763


>gi|222144235 fibroblast growth factor receptor 2 isoform 5 precursor
            [Homo sapiens]
          Length = 707

 Score =  196 bits (497), Expect = 2e-49
 Identities = 119/332 (35%), Positives = 186/332 (56%), Gaps = 29/332 (8%)

Query: 1041 SDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHE------RVVTHSDRVIGKGHFG 1094
            S S   S  PL+R  +      D+ +LA V +  +P +      R      + +G+G FG
Sbjct: 345  SSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFG 404

Query: 1095 VVYHGEYI----DQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLN-HPNVLALIGI 1149
             V   E +    D+ +  +  A+K L      + +   + E  +M+ +  H N++ L+G 
Sbjct: 405  QVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGA 464

Query: 1150 MLPPEGLPHVLLPYMCHGDLLQFIRS---------------PQRNPTVKDLISFGLQVAR 1194
                +G  +V++ Y   G+L +++R+               P+   T KDL+S   Q+AR
Sbjct: 465  CTQ-DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLAR 523

Query: 1195 GMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWM 1254
            GMEYLA QK +HRDLAARN ++ E+  +K+ADFGLARDI + +YY  ++  + RLPVKWM
Sbjct: 524  GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY--KKTTNGRLPVKWM 581

Query: 1255 ALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPD 1314
            A E+L    +T +SDVWSFGVL+WE+ T G  PY  I   +L   L +G R+ +P  C +
Sbjct: 582  APEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTN 641

Query: 1315 SLYQVMQQCWEADPAVRPTFRVLVGEVEQIVS 1346
             LY +M+ CW A P+ RPTF+ LV ++++I++
Sbjct: 642  ELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT 673


>gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
            sapiens]
          Length = 1009

 Score =  196 bits (497), Expect = 2e-49
 Identities = 121/368 (32%), Positives = 193/368 (52%), Gaps = 35/368 (9%)

Query: 1042 DSEDESCVPLLRKESIQLR--------DLDSALLAEVKDVL----------IPHERVVTH 1083
            D E  + +P +   +++ R         ++S + AE+ D            I  E VV +
Sbjct: 369  DGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLN 428

Query: 1084 SDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNV 1143
              R++G+G FG VY G Y +    +I  A+K+  +   +   E F+ E ++M+ L+HP++
Sbjct: 429  --RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 486

Query: 1144 LALIGIMLP-PEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQ 1202
            + LIGI+   P  +   L PY   G+L  ++   + +  V  L+ + LQ+ + M YL   
Sbjct: 487  VKLIGIIEEEPTWIIMELYPY---GELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESI 543

Query: 1203 KFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTY 1262
              VHRD+A RN ++     VK+ DFGL+R I D +YY        RLP+KWM+ ES+   
Sbjct: 544  NCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASV---TRLPIKWMSPESINFR 600

Query: 1263 RFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQ 1322
            RFTT SDVW F V +WE+L+ G  P+  ++  D+   L +G RLP+P+ CP  LY +M +
Sbjct: 601  RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR 660

Query: 1323 CWEADPAVRPTFRVLV---GEVEQIVSALLGDHYVQLPATYMN---LGPSTSHEMNVRPE 1376
            CW+ DP+ RP F  LV    +V Q+   +  +   +  A Y     L P+   E   +P 
Sbjct: 661  CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQ--ERNARYRTPKILEPTAFQEPPPKPS 718

Query: 1377 QPQFSPMP 1384
            +P++ P P
Sbjct: 719  RPKYRPPP 726


>gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo
            sapiens]
          Length = 967

 Score =  196 bits (497), Expect = 2e-49
 Identities = 121/368 (32%), Positives = 193/368 (52%), Gaps = 35/368 (9%)

Query: 1042 DSEDESCVPLLRKESIQLR--------DLDSALLAEVKDVL----------IPHERVVTH 1083
            D E  + +P +   +++ R         ++S + AE+ D            I  E VV +
Sbjct: 369  DGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLN 428

Query: 1084 SDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNV 1143
              R++G+G FG VY G Y +    +I  A+K+  +   +   E F+ E ++M+ L+HP++
Sbjct: 429  --RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 486

Query: 1144 LALIGIMLP-PEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQ 1202
            + LIGI+   P  +   L PY   G+L  ++   + +  V  L+ + LQ+ + M YL   
Sbjct: 487  VKLIGIIEEEPTWIIMELYPY---GELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESI 543

Query: 1203 KFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTY 1262
              VHRD+A RN ++     VK+ DFGL+R I D +YY        RLP+KWM+ ES+   
Sbjct: 544  NCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASV---TRLPIKWMSPESINFR 600

Query: 1263 RFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQ 1322
            RFTT SDVW F V +WE+L+ G  P+  ++  D+   L +G RLP+P+ CP  LY +M +
Sbjct: 601  RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR 660

Query: 1323 CWEADPAVRPTFRVLV---GEVEQIVSALLGDHYVQLPATYMN---LGPSTSHEMNVRPE 1376
            CW+ DP+ RP F  LV    +V Q+   +  +   +  A Y     L P+   E   +P 
Sbjct: 661  CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQ--ERNARYRTPKILEPTAFQEPPPKPS 718

Query: 1377 QPQFSPMP 1384
            +P++ P P
Sbjct: 719  RPKYRPPP 726


>gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
            sapiens]
          Length = 1009

 Score =  196 bits (497), Expect = 2e-49
 Identities = 121/368 (32%), Positives = 193/368 (52%), Gaps = 35/368 (9%)

Query: 1042 DSEDESCVPLLRKESIQLR--------DLDSALLAEVKDVL----------IPHERVVTH 1083
            D E  + +P +   +++ R         ++S + AE+ D            I  E VV +
Sbjct: 369  DGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLN 428

Query: 1084 SDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNV 1143
              R++G+G FG VY G Y +    +I  A+K+  +   +   E F+ E ++M+ L+HP++
Sbjct: 429  --RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 486

Query: 1144 LALIGIMLP-PEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQ 1202
            + LIGI+   P  +   L PY   G+L  ++   + +  V  L+ + LQ+ + M YL   
Sbjct: 487  VKLIGIIEEEPTWIIMELYPY---GELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESI 543

Query: 1203 KFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTY 1262
              VHRD+A RN ++     VK+ DFGL+R I D +YY        RLP+KWM+ ES+   
Sbjct: 544  NCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASV---TRLPIKWMSPESINFR 600

Query: 1263 RFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQ 1322
            RFTT SDVW F V +WE+L+ G  P+  ++  D+   L +G RLP+P+ CP  LY +M +
Sbjct: 601  RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR 660

Query: 1323 CWEADPAVRPTFRVLV---GEVEQIVSALLGDHYVQLPATYMN---LGPSTSHEMNVRPE 1376
            CW+ DP+ RP F  LV    +V Q+   +  +   +  A Y     L P+   E   +P 
Sbjct: 661  CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQ--ERNARYRTPKILEPTAFQEPPPKPS 718

Query: 1377 QPQFSPMP 1384
            +P++ P P
Sbjct: 719  RPKYRPPP 726


>gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
            sapiens]
          Length = 1009

 Score =  196 bits (497), Expect = 2e-49
 Identities = 121/368 (32%), Positives = 193/368 (52%), Gaps = 35/368 (9%)

Query: 1042 DSEDESCVPLLRKESIQLR--------DLDSALLAEVKDVL----------IPHERVVTH 1083
            D E  + +P +   +++ R         ++S + AE+ D            I  E VV +
Sbjct: 369  DGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLN 428

Query: 1084 SDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNV 1143
              R++G+G FG VY G Y +    +I  A+K+  +   +   E F+ E ++M+ L+HP++
Sbjct: 429  --RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 486

Query: 1144 LALIGIMLP-PEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQ 1202
            + LIGI+   P  +   L PY   G+L  ++   + +  V  L+ + LQ+ + M YL   
Sbjct: 487  VKLIGIIEEEPTWIIMELYPY---GELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESI 543

Query: 1203 KFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTY 1262
              VHRD+A RN ++     VK+ DFGL+R I D +YY        RLP+KWM+ ES+   
Sbjct: 544  NCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASV---TRLPIKWMSPESINFR 600

Query: 1263 RFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQ 1322
            RFTT SDVW F V +WE+L+ G  P+  ++  D+   L +G RLP+P+ CP  LY +M +
Sbjct: 601  RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR 660

Query: 1323 CWEADPAVRPTFRVLV---GEVEQIVSALLGDHYVQLPATYMN---LGPSTSHEMNVRPE 1376
            CW+ DP+ RP F  LV    +V Q+   +  +   +  A Y     L P+   E   +P 
Sbjct: 661  CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQ--ERNARYRTPKILEPTAFQEPPPKPS 718

Query: 1377 QPQFSPMP 1384
            +P++ P P
Sbjct: 719  RPKYRPPP 726


>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
          Length = 1370

 Score =  196 bits (497), Expect = 2e-49
 Identities = 110/284 (38%), Positives = 170/284 (59%), Gaps = 24/284 (8%)

Query: 1073 VLIPHERVVTHSD----RVIGKGHFGVVYHGEYID----QAQNRIQCAIKSLSRITEMQQ 1124
            V +P E  V+       R +G+G FG+VY G   D    +A+ R+  A+K+++    +++
Sbjct: 998  VYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRV--AVKTVNESASLRE 1055

Query: 1125 VEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPH-VLLPYMCHGDLLQFIRS-------- 1175
               FL E  +M+G    +V+ L+G++   +G P  V++  M HGDL  ++RS        
Sbjct: 1056 RIEFLNEASVMKGFTCHHVVRLLGVV--SKGQPTLVVMELMAHGDLKSYLRSLRPEAENN 1113

Query: 1176 PQRNP-TVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDIL 1234
            P R P T++++I    ++A GM YL  +KFVHRDLAARNCM+   FTVK+ DFG+ RDI 
Sbjct: 1114 PGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIY 1173

Query: 1235 DREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPF 1294
            + +YY  ++     LPV+WMA ESL+   FTT SD+WSFGV+LWE+ +    PY+ +   
Sbjct: 1174 ETDYY--RKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNE 1231

Query: 1295 DLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLV 1338
             +  F+  G  L QP+ CP+ +  +M+ CW+ +P +RPTF  +V
Sbjct: 1232 QVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIV 1275


>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
          Length = 1382

 Score =  196 bits (497), Expect = 2e-49
 Identities = 110/284 (38%), Positives = 170/284 (59%), Gaps = 24/284 (8%)

Query: 1073 VLIPHERVVTHSD----RVIGKGHFGVVYHGEYID----QAQNRIQCAIKSLSRITEMQQ 1124
            V +P E  V+       R +G+G FG+VY G   D    +A+ R+  A+K+++    +++
Sbjct: 1010 VYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRV--AVKTVNESASLRE 1067

Query: 1125 VEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPH-VLLPYMCHGDLLQFIRS-------- 1175
               FL E  +M+G    +V+ L+G++   +G P  V++  M HGDL  ++RS        
Sbjct: 1068 RIEFLNEASVMKGFTCHHVVRLLGVV--SKGQPTLVVMELMAHGDLKSYLRSLRPEAENN 1125

Query: 1176 PQRNP-TVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDIL 1234
            P R P T++++I    ++A GM YL  +KFVHRDLAARNCM+   FTVK+ DFG+ RDI 
Sbjct: 1126 PGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIY 1185

Query: 1235 DREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPF 1294
            + +YY  ++     LPV+WMA ESL+   FTT SD+WSFGV+LWE+ +    PY+ +   
Sbjct: 1186 ETDYY--RKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNE 1243

Query: 1295 DLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLV 1338
             +  F+  G  L QP+ CP+ +  +M+ CW+ +P +RPTF  +V
Sbjct: 1244 QVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIV 1287


>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
          Length = 2347

 Score =  195 bits (495), Expect = 3e-49
 Identities = 109/281 (38%), Positives = 160/281 (56%), Gaps = 17/281 (6%)

Query: 1087 VIGKGHFGVVYHGEYID---QAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNV 1143
            ++G G FG VY G  +D        I+ A+K+L + +  Q+   FL+E  LM   NHPN+
Sbjct: 1950 LLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNI 2009

Query: 1144 LALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNP------TVKDLISFGLQVARGME 1197
            L  +G+ L  E   +++L  M  GDLL ++R  +         T+ DL+   + +++G  
Sbjct: 2010 LKQLGVCLLNEP-QYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCV 2068

Query: 1198 YLAEQKFVHRDLAARNCMLD-ESFT----VKVADFGLARDILDREYYSVQQHRHARLPVK 1252
            YL    F+HRDLAARNC++  + +T    VK+ DFGLARDI   +YY  ++     LPV+
Sbjct: 2069 YLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYY--RKRGEGLLPVR 2126

Query: 1253 WMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYC 1312
            WMA ESL    FTT+SDVWSFG+L+WE+LT G  PY      D+ +++  G RL  P  C
Sbjct: 2127 WMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNC 2186

Query: 1313 PDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHY 1353
            PD L+ +M QCW  +P  RPTF  +  +++   +  L   Y
Sbjct: 2187 PDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIY 2227


>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
            [Homo sapiens]
          Length = 731

 Score =  194 bits (493), Expect = 5e-49
 Identities = 116/312 (37%), Positives = 176/312 (56%), Gaps = 25/312 (8%)

Query: 1075 IPHERVVTHSDRVIGKGHFGVVYHGEYI----DQAQNRIQCAIKSLSRITEMQQVEAFLR 1130
            +P +R+V    + +G+G FG V   E I    D+     + A+K L      + +   + 
Sbjct: 382  LPRDRLVL--GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLIS 439

Query: 1131 EGLLMRGLN-HPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRS-----------PQR 1178
            E  +M+ +  H N++ L+G     +G  +V++ Y   G+L +++++           P  
Sbjct: 440  EMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSH 498

Query: 1179 NP----TVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDIL 1234
            NP    + KDL+S   QVARGMEYLA +K +HRDLAARN ++ E   +K+ADFGLARDI 
Sbjct: 499  NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH 558

Query: 1235 DREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPF 1294
              +YY  ++  + RLPVKWMA E+L    +T +SDVWSFGVLLWE+ T G  PY  +   
Sbjct: 559  HIDYY--KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE 616

Query: 1295 DLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYV 1354
            +L   L +G R+ +P  C + LY +M+ CW A P+ RPTF+ LV ++++IV+      Y+
Sbjct: 617  ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYL 676

Query: 1355 QLPATYMNLGPS 1366
             L        PS
Sbjct: 677  DLSMPLDQYSPS 688


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.139    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,194,520
Number of Sequences: 37866
Number of extensions: 3456282
Number of successful extensions: 12105
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 548
Number of HSP's successfully gapped in prelim test: 261
Number of HSP's that attempted gapping in prelim test: 9722
Number of HSP's gapped (non-prelim): 1428
length of query: 1400
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1285
effective length of database: 13,892,928
effective search space: 17852412480
effective search space used: 17852412480
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.