Search of human proteins with 153218660

Search of human proteins with 153218660

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|153218660 cytochrome P450, family 4, subfamily B,
polypeptide 1 isoform b [Homo sapiens]
         (511 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide...  1063   0.0  
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide...  1058   0.0  
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide...   529   e-150
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ...   496   e-140
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ...   472   e-133
gi|30023836 cytochrome P450 4Z1 [Homo sapiens]                        456   e-128
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ...   418   e-117
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...   414   e-115
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...   414   e-115
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide...   409   e-114
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...   409   e-114
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...   399   e-111
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide...   399   e-111
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   248   7e-66
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   148   1e-35
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   146   5e-35
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   142   7e-34
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   139   6e-33
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   139   6e-33
gi|5729796 cytochrome P450, family 46 [Homo sapiens]                  124   2e-28
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H...   111   1e-24
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H...   111   1e-24
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   110   4e-24
gi|239757171 PREDICTED: similar to cytochrome P450, family 4, su...   102   8e-22
gi|239751683 PREDICTED: similar to cytochrome P450, family 4, su...   102   8e-22
gi|239746187 PREDICTED: similar to cytochrome P450, family 4, su...   102   8e-22
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...   102   1e-21
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ...    99   9e-21
gi|225903399 cytochrome P450, family 51, subfamily A, polypeptid...    99   1e-20
gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide ...    99   1e-20

>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform b [Homo sapiens]
          Length = 511

 Score = 1063 bits (2749), Expect = 0.0
 Identities = 511/511 (100%), Positives = 511/511 (100%)

Query: 1   MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE 60
           MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE
Sbjct: 1   MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE 60

Query: 61  IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ 120
           IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ
Sbjct: 61  IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ 120

Query: 121 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 180
           WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI
Sbjct: 121 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 180

Query: 181 FCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLT 240
           FCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLT
Sbjct: 181 FCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLT 240

Query: 241 PHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKL 300
           PHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKL
Sbjct: 241 PHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKL 300

Query: 301 SDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDL 360
           SDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDL
Sbjct: 301 SDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDL 360

Query: 361 GKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWP 420
           GKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWP
Sbjct: 361 GKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWP 420

Query: 421 DPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDP 480
           DPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDP
Sbjct: 421 DPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDP 480

Query: 481 SRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK 511
           SRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
Sbjct: 481 SRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK 511


>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform a [Homo sapiens]
          Length = 512

 Score = 1058 bits (2737), Expect = 0.0
 Identities = 511/512 (99%), Positives = 511/512 (99%), Gaps = 1/512 (0%)

Query: 1   MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE 60
           MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE
Sbjct: 1   MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE 60

Query: 61  IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ 120
           IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ
Sbjct: 61  IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ 120

Query: 121 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 180
           WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI
Sbjct: 121 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 180

Query: 181 FCDVGHMALNTLMKCTFGRGDTGLGH-RDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL 239
           FCDVGHMALNTLMKCTFGRGDTGLGH RDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL
Sbjct: 181 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL 240

Query: 240 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK 299
           TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK
Sbjct: 241 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK 300

Query: 300 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD 359
           LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD
Sbjct: 301 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD 360

Query: 360 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW 419
           LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW
Sbjct: 361 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW 420

Query: 420 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD 479
           PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD
Sbjct: 421 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD 480

Query: 480 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK 511
           PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
Sbjct: 481 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK 512


>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
           [Homo sapiens]
          Length = 519

 Score =  529 bits (1363), Expect = e-150
 Identities = 267/504 (52%), Positives = 336/504 (66%), Gaps = 3/504 (0%)

Query: 3   PSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQ 62
           PS L    S +   AS LIL+L  +K + L L RQ L KA+ +FP PP+HWLFGH  E+Q
Sbjct: 8   PSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQ 67

Query: 63  ETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWI 122
           +   L ++  W   FP A P W       + +Y+PDY K +  R DPK+   Y F   WI
Sbjct: 68  QDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWI 127

Query: 123 GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFC 182
           G GLL+L G  W QHR++LTP FHYD+LKPYV +  +S R+MLDKWEE   +    ++F 
Sbjct: 128 GYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQ 187

Query: 183 DVGHMALNTLMKCTFG-RGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTP 241
            V  M L+T+MKC F  +G   +     SY  A+SDL  L+  R+ +  + ND IY LT 
Sbjct: 188 HVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTS 247

Query: 242 HGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLS 301
            GR   RACQ+AH HTDQVI+ RKA LQ E   +KI+ +RHLDFLDILL A+ E+   LS
Sbjct: 248 AGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILS 307

Query: 302 DADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLG 361
           D DLRAEVDTFMFEGHDTT SGISW LY +A +P+HQ RCREE+  +LGD     W+ L 
Sbjct: 308 DKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLD 367

Query: 362 KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPD 421
           +M Y TMCIKE+ RLYPPVP + R+LS PVTF DGRSLP G ++ + IY LH N  VWP+
Sbjct: 368 QMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPN 427

Query: 422 PEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPS 481
           PEVFD  RF+    S +H  AF+PFS G RNCIG+QFAM+E+KV TA+ LLRFE   DP+
Sbjct: 428 PEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPT 485

Query: 482 RLPIKMPQLVLRSKNGFHLHLKPL 505
           R+PI + +LVL+SKNG HL L+ L
Sbjct: 486 RIPIPIARLVLKSKNGIHLRLRRL 509


>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
           [Homo sapiens]
          Length = 519

 Score =  496 bits (1276), Expect = e-140
 Identities = 254/487 (52%), Positives = 319/487 (65%), Gaps = 3/487 (0%)

Query: 20  LILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPY 79
           LIL+L  +K   L L RQ L KA+ +FP PP+HWLFGH  E Q    L ++      FP 
Sbjct: 25  LILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFPS 84

Query: 80  AHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRK 139
           A P W       + +Y+PDY K +  R DPK+   Y F    IG GLL+L G  W QHR+
Sbjct: 85  ACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHRR 144

Query: 140 LLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFG- 198
           +LTP FH D+LKPYV +  +S R+MLDKWEE   +    ++F  V  M L+T+MK  F  
Sbjct: 145 MLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSH 204

Query: 199 RGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTD 258
           +G   +     SY  A+SDL  L+   + +  + ND IY LT  GR   RACQ+AH HTD
Sbjct: 205 QGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTD 264

Query: 259 QVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHD 318
           QVI+ RKA LQ E   +KI+ +RHLDFLDILL A+ E+   LSD DLRAEVDTFMFEGHD
Sbjct: 265 QVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHD 324

Query: 319 TTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYP 378
           TT SGISW LY +A +P+HQ RCREE+  +LGD     W+ L +M Y TMCIKE+ RLYP
Sbjct: 325 TTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYP 384

Query: 379 PVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKR 438
           PVP + R+LS PVTF DGRSLP G ++ + IY LH N  VWP+ EVFD  RF+    S +
Sbjct: 385 PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAP--GSAQ 442

Query: 439 HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGF 498
           H  AF+PFS G RNCIG+QFAM+++KV  A+ LLRFE   DP+R+PI M +LVL+SKNG 
Sbjct: 443 HSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGI 502

Query: 499 HLHLKPL 505
           HL L+ L
Sbjct: 503 HLRLRRL 509


>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
           [Homo sapiens]
          Length = 509

 Score =  472 bits (1215), Expect = e-133
 Identities = 235/489 (48%), Positives = 320/489 (65%), Gaps = 9/489 (1%)

Query: 22  LVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAH 81
           L LG L+ I L LRRQ L + +  FP PPTHW  GH   IQ+  +++K+     ++P A 
Sbjct: 22  LALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKFIQDD-NMEKLEEIIEKYPRAF 80

Query: 82  PLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLL 141
           P W G F  F  IY+PDYAK + SR DPK+  +  F    +G+GL  L+GPKW QHR+LL
Sbjct: 81  PFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLL 140

Query: 142 TPGFHYDVLKPYVAVFTESTRIMLDKWEEK-AREGKSFDIFCDVGHMALNTLMKCTFGRG 200
           TPGFH+++LK Y+ V   S ++MLDKWE+  + +  S +++  +  M+L+ +MKC F + 
Sbjct: 141 TPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKE 200

Query: 201 ---DTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHT 257
               T   H    Y  A+ +L+ ++  RL S  YH+D I+ L+P G RF +  +V + +T
Sbjct: 201 TNCQTNSTH--DPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYT 258

Query: 258 DQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGH 317
           D +I+ERK +LQ    +     R++ DFLDI+L A+DE     SD D+ +EV TF+  GH
Sbjct: 259 DTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGH 318

Query: 318 DTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLY 377
           DT  + ISW LYC+AL PEHQ RCREEVR ILGD     WD LG+M+Y TMCIKE+ RL 
Sbjct: 319 DTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLI 378

Query: 378 PPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASK 437
           P VP + R LSKP+TF DG +LPAG  + + I+ LH N AVW +P+VFD LRFS EN+ +
Sbjct: 379 PAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQ 438

Query: 438 RHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKN 496
           RHP+A++PFSAG RNCIGQ+FAM E+KV  A+ LL F  + DP+R P+  P   +L+ KN
Sbjct: 439 RHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTR-PLTFPNHFILKPKN 497

Query: 497 GFHLHLKPL 505
           G +LHLK L
Sbjct: 498 GMYLHLKKL 506


>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
          Length = 505

 Score =  456 bits (1173), Expect = e-128
 Identities = 228/504 (45%), Positives = 321/504 (63%), Gaps = 3/504 (0%)

Query: 1   MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE 60
           M PS+L    +   L    L + L   ++I L  RR+ + +A+  FP PP HW +GH  E
Sbjct: 1   MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHK-E 59

Query: 61  IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ 120
                  +       ++P A PLW G F  F ++++PDYAK +  R DPK+   +     
Sbjct: 60  FYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILES 119

Query: 121 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 180
           W+GRGL+ L+G KW +HR+++ PGF+  +LK ++ + +ES R+ML+KWEE   +    ++
Sbjct: 120 WVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLEL 179

Query: 181 FCDVGHMALNTLMKCTFG-RGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL 239
           F  V  M L+++MKC F  +G   L     SY  AV +L+ +  QR+ +F +HND ++  
Sbjct: 180 FQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKF 239

Query: 240 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK 299
           +  G+ F +  Q  H  T++VI++RK +L+D K+++    +R  DFLDILL A+ E+   
Sbjct: 240 SSQGQIFSKFNQELHQFTEKVIQDRKESLKD-KLKQDTTQKRRWDFLDILLSAKSENTKD 298

Query: 300 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD 359
            S+ADL+AEV TFMF GHDTT+S ISW LYC+A YPEHQ RCR+E+RE+LGD     W+ 
Sbjct: 299 FSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEH 358

Query: 360 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW 419
           L +M Y TMCIKE  RLY PV  + R L KP+TF DGRSLPAG  + ++I+ALH N   W
Sbjct: 359 LSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFW 418

Query: 420 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD 479
            DP+VF+ LRFS EN+ K HP+AF+PFSAG RNCIGQ FA+ E KV  A+ LLRF+ + D
Sbjct: 419 EDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPD 478

Query: 480 PSRLPIKMPQLVLRSKNGFHLHLK 503
            SR P  + Q+VL+SKNG H+  K
Sbjct: 479 HSRPPQPVRQVVLKSKNGIHVFAK 502


>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
           [Homo sapiens]
          Length = 520

 Score =  418 bits (1075), Expect = e-117
 Identities = 225/518 (43%), Positives = 317/518 (61%), Gaps = 22/518 (4%)

Query: 8   LSFSSLGLWASG------LILVLGFLKLIHLLLRRQTL---AKAMDKFPGPPT-HWLFGH 57
           LS S LGLW         L+LV     L H+L          + +  FP PP  +W +GH
Sbjct: 4   LSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGH 63

Query: 58  ALEIQETGSLDKVVSW-AHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPD--- 113
              +  T    +V++     +P    +W G     L++  PD  ++V +     AP    
Sbjct: 64  QGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKF 123

Query: 114 VYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAR 173
            Y F   W+G GLL+  G KW +HR++LTP FH+++LKPY+ +F ES  IM  KW+  A 
Sbjct: 124 FYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLAS 183

Query: 174 EGKS-FDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYH 232
           EG +  D+F  +  M L++L KC F   D+    + S Y  A+ +L+ L+ +R      H
Sbjct: 184 EGSACLDMFEHISLMTLDSLQKCVFSF-DSHCQEKPSEYIAAILELSALVSKRHHEILLH 242

Query: 233 NDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNR---RHLDFLDIL 289
            DF+Y+LTP G+RF RAC++ HD TD VI+ER+  L  + V   +Q +   + LDF+D+L
Sbjct: 243 IDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVL 302

Query: 290 LGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREIL 349
           L ++DED  KLSD D+RAE DTFMFEGHDTT SG+SW LY +A +PE+Q RCR+EV+E+L
Sbjct: 303 LLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELL 362

Query: 350 GDQD--FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISM 407
            D++    +WDDL  + +LTMC+KES RL+PPVP + R +++ +   DGR +P G +  +
Sbjct: 363 KDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLI 422

Query: 408 HIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVT 467
            ++  H N AVWPDPEV+D  RF  EN  +R P AF+PFSAGPRNCIGQ FAM+EMKVV 
Sbjct: 423 SVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVL 482

Query: 468 AMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPL 505
           A+ LLRF    D +  P + P+LVLR++ G  L ++PL
Sbjct: 483 ALTLLRFRVLPDHTE-PRRKPELVLRAEGGLWLRVEPL 519


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  414 bits (1064), Expect = e-115
 Identities = 222/522 (42%), Positives = 316/522 (60%), Gaps = 20/522 (3%)

Query: 6   LSLSFSSLGLWASG----LILVLGFLKLIHLLLRRQTL---AKAMDKFPGPPT-HWLFGH 57
           LSLS+  LG  A+     L+LV G   L  +L    T     + +  FP PP  +W +GH
Sbjct: 4   LSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGH 63

Query: 58  ALEIQETGS-LDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPD--- 113
              +  T   +  +      +P    LW G     L +  PD  + + S     AP    
Sbjct: 64  QGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMI 123

Query: 114 VYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAR 173
            Y F   W+G GLL+  G KW +HR++LTP FH+++LKPY+ +F +S  IM DKW+  A 
Sbjct: 124 FYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLAS 183

Query: 174 EGKS-FDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYH 232
           EG +  D+F  +  M L++L KC F   ++    + S Y  A+ +L+  +++R      H
Sbjct: 184 EGSARLDMFEHISLMTLDSLQKCVFSF-ESNCQEKPSEYIAAILELSAFVEKRNQQILLH 242

Query: 233 NDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNR---RHLDFLDIL 289
            DF+Y+LTP G+RF RAC + HD TD VI+ER+  L  + +   ++N+   + LDF+D+L
Sbjct: 243 TDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVL 302

Query: 290 LGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREIL 349
           L ++DED  +LSD D+RAE DTFMFEGHDTT SG+SW LY +A +PE+Q +CR+EV+E+L
Sbjct: 303 LLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELL 362

Query: 350 GDQD--FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISM 407
            D++    +WDDL ++ +LTMCIKES RL+PPVP + R  ++     DGR +P G +  +
Sbjct: 363 KDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLI 422

Query: 408 HIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVT 467
           +I  +H N  VWPDPEV+D  RF  EN  +R P AF+PFSAGPRNCIGQ FAM+EMKVV 
Sbjct: 423 NIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482

Query: 468 AMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGS 509
           A+ LL F   L     P + P+L+LR++ G  L ++PLG  S
Sbjct: 483 ALTLLHFRI-LPTHTEPRRKPELILRAEGGLWLRVEPLGANS 523


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  414 bits (1064), Expect = e-115
 Identities = 222/522 (42%), Positives = 316/522 (60%), Gaps = 20/522 (3%)

Query: 6   LSLSFSSLGLWASG----LILVLGFLKLIHLLLRRQTL---AKAMDKFPGPPT-HWLFGH 57
           LSLS+  LG  A+     L+LV G   L  +L    T     + +  FP PP  +W +GH
Sbjct: 4   LSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGH 63

Query: 58  ALEIQETGS-LDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPD--- 113
              +  T   +  +      +P    LW G     L +  PD  + + S     AP    
Sbjct: 64  QGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMI 123

Query: 114 VYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAR 173
            Y F   W+G GLL+  G KW +HR++LTP FH+++LKPY+ +F +S  IM DKW+  A 
Sbjct: 124 FYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLAS 183

Query: 174 EGKS-FDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYH 232
           EG +  D+F  +  M L++L KC F   ++    + S Y  A+ +L+  +++R      H
Sbjct: 184 EGSARLDMFEHISLMTLDSLQKCVFSF-ESNCQEKPSEYIAAILELSAFVEKRNQQILLH 242

Query: 233 NDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNR---RHLDFLDIL 289
            DF+Y+LTP G+RF RAC + HD TD VI+ER+  L  + +   ++N+   + LDF+D+L
Sbjct: 243 TDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVL 302

Query: 290 LGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREIL 349
           L ++DED  +LSD D+RAE DTFMFEGHDTT SG+SW LY +A +PE+Q +CR+EV+E+L
Sbjct: 303 LLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELL 362

Query: 350 GDQD--FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISM 407
            D++    +WDDL ++ +LTMCIKES RL+PPVP + R  ++     DGR +P G +  +
Sbjct: 363 KDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLI 422

Query: 408 HIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVT 467
           +I  +H N  VWPDPEV+D  RF  EN  +R P AF+PFSAGPRNCIGQ FAM+EMKVV 
Sbjct: 423 NIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482

Query: 468 AMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGS 509
           A+ LL F   L     P + P+L+LR++ G  L ++PLG  S
Sbjct: 483 ALTLLHFRI-LPTHTEPRRKPELILRAEGGLWLRVEPLGANS 523


>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
           [Homo sapiens]
          Length = 520

 Score =  409 bits (1051), Expect = e-114
 Identities = 229/519 (44%), Positives = 312/519 (60%), Gaps = 24/519 (4%)

Query: 8   LSFSSLGLWASG------LILVLGFLKLIHLLLRRQTLAKAMDK---FPGPPT-HWLFGH 57
           LS SSLGLW         L+LV     L  +L    T      +   FP PP  +W  GH
Sbjct: 4   LSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGH 63

Query: 58  A--LEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGD---PKAP 112
              +   E G L    S A  F      W G +   + I+ P Y K V        PK  
Sbjct: 64  LGLIHSSEEGLL-YTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDK 122

Query: 113 DVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKA 172
             Y F   W+G GLL+  G KW +HR++LTP FH+++LKPY+ +F ES  IM  KW+  A
Sbjct: 123 VFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLA 182

Query: 173 REGKS-FDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQY 231
            EG +  D+F  +  M L++L KC F   D+    + S Y  A+ +L+ L+ +R      
Sbjct: 183 SEGSARLDMFEHISLMTLDSLQKCVFSF-DSHCQEKPSEYIAAILELSALVTKRHQQILL 241

Query: 232 HNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNR---RHLDFLDI 288
           + DF+Y+LTP G+RF RAC++ HD TD VI+ER+  L  + V   +Q +   + LDF+D+
Sbjct: 242 YIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDV 301

Query: 289 LLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREI 348
           LL ++DED  KLSD D+RAE DTFMFEGHDTT SG+SW LY +A +PE+Q RCR+EV+E+
Sbjct: 302 LLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQEL 361

Query: 349 LGDQD--FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLIS 406
           L D++    +WDDL ++ +LTMCIKES RL+PPVP V R  ++ +   DGR +P G +  
Sbjct: 362 LKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICL 421

Query: 407 MHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVV 466
           + ++  H N AVWPDPEV+D  RF  +N  +R P AF+PFSAGPRNCIGQ FAM+EMKVV
Sbjct: 422 ISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVV 481

Query: 467 TAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPL 505
             + LLRF    D +  P + P+LVLR++ G  L ++PL
Sbjct: 482 LGLTLLRFRVLPDHTE-PRRKPELVLRAEGGLWLRVEPL 519


>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score =  409 bits (1051), Expect = e-114
 Identities = 223/521 (42%), Positives = 321/521 (61%), Gaps = 20/521 (3%)

Query: 4   SFLSLSFSSLGLWASG---LILVLGFLKLIHLLLRRQTL----AKAMDKFPGP-PTHWLF 55
           S LSLS+  L   A+    L+LV+G   L+  +L          + +  FP P   +W  
Sbjct: 2   SLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFL 61

Query: 56  GHALEIQETGS-LDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDP---KA 111
           GH   +  T   L  +      +P     W G     +N+  PD  ++V +  D    K 
Sbjct: 62  GHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKD 121

Query: 112 PDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEK 171
              Y     W+G GLL+  G KW  HR+LLTP FH+++LKPY+ +F++S  IM  KW+  
Sbjct: 122 IVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRL 181

Query: 172 AREGKS-FDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQ 230
           A EG +  D+F  +  M L++L KC F   D+    + S Y  A+ +L+ L+ +R   F 
Sbjct: 182 AMEGSTCLDVFEHISLMTLDSLQKCIFSF-DSNCQEKPSEYITAIMELSALVVKRNNQFF 240

Query: 231 YHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNR---RHLDFLD 287
            + DF+Y+LTP GRRF RAC++ HD TD VI+ER+  L  + V   +Q +   + LDF+D
Sbjct: 241 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID 300

Query: 288 ILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVRE 347
           +LL + D++  +LSD D+RAE DTFMF GHDTT SG+SW LY +A +PE+Q RCR+EV+E
Sbjct: 301 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360

Query: 348 ILGDQD--FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLI 405
           +L D++    +WDDL ++ +LTMC+KES RL+PP+P   R  ++ V   D R +P G++ 
Sbjct: 361 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC 420

Query: 406 SMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKV 465
           +++I+A+H N +VWPDPEV+D  RF  ENA KR P AF+PFSAGPRNCIGQ+FAM+EMKV
Sbjct: 421 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV 480

Query: 466 VTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLG 506
           V A+ LLRF   L   R P + P++VLR+++G  L ++PLG
Sbjct: 481 VLALTLLRFRI-LPDHREPRRTPEIVLRAEDGLWLRVEPLG 520


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score =  399 bits (1025), Expect = e-111
 Identities = 212/503 (42%), Positives = 308/503 (61%), Gaps = 16/503 (3%)

Query: 20  LILVLGFLKLIHLLLRRQTL---AKAMDKFPGPPT-HWLFGHALEIQETGS-LDKVVSWA 74
           L+LV+G   L  +L          + +  FP PP  +W +GH   I  T   L      +
Sbjct: 22  LLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKDSTQMS 81

Query: 75  HQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAP--DVYDFFLQ-WIGRGLLVLEG 131
             +     +W G  I F+ +  PD  +++ +     AP  +++  FL+ W+G G+L+  G
Sbjct: 82  ATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGG 141

Query: 132 PKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKS-FDIFCDVGHMALN 190
            KW +HR++LTP FH+++LK Y+ +F +S  IMLDKW+  A EG S  D+F  +  M L+
Sbjct: 142 DKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLD 201

Query: 191 TLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRAC 250
           +L KC F   D+    R S Y   + +L+ L+++R      H DF+Y+L+  GRRF RAC
Sbjct: 202 SLQKCIFSF-DSHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRAC 260

Query: 251 QVAHDHTDQVIRERKAALQDEKVRKKIQNR---RHLDFLDILLGARDEDDIKLSDADLRA 307
           ++ HD TD VIRER+  L  + +    +++   + LDF+D+LL ++DED   LSD D+RA
Sbjct: 261 RLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRA 320

Query: 308 EVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD--FFQWDDLGKMTY 365
           E DTFMF GHDTT SG+SW LY +A +PE+Q RCR+EV+E+L D+D    +WDDL ++ +
Sbjct: 321 EADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPF 380

Query: 366 LTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVF 425
           LTMC+KES RL+PP P + R  ++ +   DGR +P G    + I  +H N  VWPDPEV+
Sbjct: 381 LTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVY 440

Query: 426 DSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPI 485
           D  RF  EN+  R P AF+PFSAGPRNCIGQ FAM+EMKVV A+ LL F F  D +  P 
Sbjct: 441 DPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTE-PR 499

Query: 486 KMPQLVLRSKNGFHLHLKPLGPG 508
           +  +L++R++ G  L ++PL  G
Sbjct: 500 RKLELIMRAEGGLWLRVEPLNVG 522


>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
           [Homo sapiens]
          Length = 531

 Score =  399 bits (1025), Expect = e-111
 Identities = 212/519 (40%), Positives = 308/519 (59%), Gaps = 18/519 (3%)

Query: 6   LSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKA-------MDKFPGPPT-HWLFGH 57
           L L  ++  ++A   +L+     L  LLLR   L ++       +  FP PP  +WL GH
Sbjct: 12  LGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGH 71

Query: 58  -ALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPD--- 113
             + +     L           +   +W G  +  L +  PDY K +       AP    
Sbjct: 72  LGMYLPNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDL 131

Query: 114 VYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAR 173
            Y F   W+G GLL+ +G KW +HR+LLTP FH+D+LKPY+ +F +S  IM  KW   A 
Sbjct: 132 FYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAE 191

Query: 174 -EGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYH 232
               S D+F  +  M L++L KC F   ++    + S Y  A+ +L+ L  +R     ++
Sbjct: 192 GSAVSLDMFEHISLMTLDSLQKCVFSY-NSNCQEKMSDYISAIIELSALSVRRQYRLHHY 250

Query: 233 NDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRK--KIQNRRHLDFLDILL 290
            DFIY+ +  GRRF +AC + H  T +VI+ER+ AL+ +      K +  + LDF+D+LL
Sbjct: 251 LDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLL 310

Query: 291 GARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILG 350
            ARDED  +LSD D+RAE DTFMFEGHDTT+SGISW L+ +A YPE+Q +CREE++E++ 
Sbjct: 311 LARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMK 370

Query: 351 DQDF--FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMH 408
            ++    +WDDL ++ + TMCIKES R YPPV  V RQ ++ +   DGR +P G +  + 
Sbjct: 371 GRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVS 430

Query: 409 IYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTA 468
           IY  H N  VWPD +V++  RF  +N  +R P A++PFSAGPRNCIGQ FAM+E++VV A
Sbjct: 431 IYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVA 490

Query: 469 MCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGP 507
           + LLRF  S+D +R   + P+L+LR++NG  L ++PL P
Sbjct: 491 LTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPLPP 529


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  248 bits (634), Expect = 7e-66
 Identities = 166/522 (31%), Positives = 263/522 (50%), Gaps = 23/522 (4%)

Query: 1   MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRR-QTLAKAMDKFPGPPT----HWLF 55
           M   +L L +  L LW +   L L    L+  LL+R  + A+   +    PT    + L 
Sbjct: 1   MAGLWLGLVWQKLLLWGAASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLV 60

Query: 56  GHALEIQETGS--LDKVVSWAHQFPYAH--PLWFGQFIGFLNIYEPDYAKAVYSRGDP-K 110
           GHAL ++  G     +++ +  ++ +     LW G  +  + +Y  +  + + +      
Sbjct: 61  GHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGP-VPMVALYNAENVEVILTSSKQID 119

Query: 111 APDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEE 170
              +Y F   W+G GLL   G KW   RK+LTP FH+ +L+ ++ +  E   I++ K E+
Sbjct: 120 KSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEK 179

Query: 171 KAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQ 230
              + ++F+ F  +   AL+ + +   G+      + DS Y  AV  ++ ++ +R+    
Sbjct: 180 HINQ-EAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPW 238

Query: 231 YHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ-------DEKVRKKIQNRRHL 283
              D  Y +   G    ++ Q+ H  T+ VI ER   +        D +     +N+R  
Sbjct: 239 LWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRA 298

Query: 284 DFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCRE 343
            FLD+LL   D++  +LS  D+R EVDTFMFEGHDTT + I+W LY +   PE Q +   
Sbjct: 299 -FLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDH 357

Query: 344 EVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAG 402
           E+ ++ G  D     +DL K+ YL   IKE+ RL+P VP   R +S+       R L   
Sbjct: 358 ELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGT 417

Query: 403 SLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSE 462
             + +  YALHR+   +P+PE F   RF  ENA  RHP+A++PFSAGPRNCIGQ+FA+ E
Sbjct: 418 EAVIIP-YALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVME 476

Query: 463 MKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLK 503
            K + +  L  F    +  R  + +  QL+LR  NG  + LK
Sbjct: 477 EKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLK 518


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  148 bits (373), Expect = 1e-35
 Identities = 96/370 (25%), Positives = 185/370 (50%), Gaps = 22/370 (5%)

Query: 128 VLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHM 187
           + E  +W + R LL+P F    LK  V +  +   +++     +A  GK   +    G  
Sbjct: 120 IAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAY 179

Query: 188 ALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHG---- 243
           +++ +   +FG     L +    +        +   ++L+ F + + F   +T       
Sbjct: 180 SMDVITSTSFGVNIDSLNNPQDPF--------VENTKKLLRFDFLDPFFLSITVFPFLIP 231

Query: 244 -RRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK--- 299
               L  C    + T+ +   RK+  + ++ R +   +  +DFL +++ +++  + +   
Sbjct: 232 ILEVLNICVFPREVTNFL---RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHK 288

Query: 300 -LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWD 358
            LSD +L A+   F+F G++TT+S +S+ +Y +A +P+ Q + +EE+  +L ++    +D
Sbjct: 289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYD 348

Query: 359 DLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAV 418
            + +M YL M + E+ RL+P   ++ R   K V  ++G  +P G ++ +  YALHR+   
Sbjct: 349 TVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVE-INGMFIPKGVVVMIPSYALHRDPKY 407

Query: 419 WPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFS- 477
           W +PE F   RFS +N     P+ + PF +GPRNCIG +FA+  MK+     L  F F  
Sbjct: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467

Query: 478 LDPSRLPIKM 487
              +++P+K+
Sbjct: 468 CKETQIPLKL 477


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  146 bits (368), Expect = 5e-35
 Identities = 110/427 (25%), Positives = 197/427 (46%), Gaps = 32/427 (7%)

Query: 92  LNIYEPDYAKAVYSRGDPKAPDVYDFFLQ--------WIGRGLLVLEGPKWLQHRKLLTP 143
           L I +PD  K V  +      + Y  F          ++   + + E  +W + R LL+P
Sbjct: 82  LAITDPDMIKTVLVK------ECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSP 135

Query: 144 GFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTG 203
            F    LK  V +  +   +++     +A  GK   +    G  +++ +   +FG     
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDS 195

Query: 204 LGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRE 263
           L +    +    +   LL    L  F        +LTP     L A  +       +   
Sbjct: 196 LNNPQDPF--VENTKKLLRFNPLDPFVLSIKVFPFLTP----ILEALNITVFPRKVISFL 249

Query: 264 RKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK----LSDADLRAEVDTFMFEGHDT 319
            K+  Q ++ R K   +  +DFL +++ +++  D +    LSD +L A+   F+F G++T
Sbjct: 250 TKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYET 309

Query: 320 TTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPP 379
           T+S +S+ +Y +A +P+ Q + ++E+  +L ++    +D + ++ YL M + E+ RL+P 
Sbjct: 310 TSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPV 369

Query: 380 VPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRH 439
             ++ R   K V  ++G  +P G ++ +  Y LH +   W +PE F   RFS +N     
Sbjct: 370 AMRLERVCKKDVE-INGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNID 428

Query: 440 PFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSK-NGF 498
           P+ + PF +GPRNCIG +FA+  MK+     L  F F       P K  Q+ L+ +  G 
Sbjct: 429 PYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFK------PCKETQIPLKLRFGGL 482

Query: 499 HLHLKPL 505
            L  KP+
Sbjct: 483 LLTEKPI 489


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  142 bits (358), Expect = 7e-34
 Identities = 106/421 (25%), Positives = 197/421 (46%), Gaps = 44/421 (10%)

Query: 92  LNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRG--------LLVLEGPKWLQHRKLLTP 143
           L I +PD  K V  +      + Y  F   +  G        L   E  +W + R LL+P
Sbjct: 82  LVIMDPDMIKTVLVK------ECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSP 135

Query: 144 GFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTG 203
            F     K  V + ++   +++    ++A   KS ++    G   ++ +    FG     
Sbjct: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDS 195

Query: 204 LGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIY------WLTPHGRRF---LRACQVAH 254
           L +    +        L   ++L+   + + F+       +LTP        L    V H
Sbjct: 196 LNNPQDPF--------LKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTH 247

Query: 255 DHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK----LSDADLRAEVD 310
              + + R +++ L+D++       +  +DF   ++ +++  + K    LSD +L A+  
Sbjct: 248 FLKNSIERMKESRLKDKQ-------KHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300

Query: 311 TFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCI 370
             +F  +DTT++ + + +Y +A +P+ Q + +EE+  +L ++    +D L +M YL M +
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360

Query: 371 KESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRF 430
            E+ RL+P V +V R   K +  ++G  +P G  + + IYALH +   W +PE F   RF
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIE-INGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERF 419

Query: 431 STENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFS-LDPSRLPIKMPQ 489
           S +N      + ++PF AGPRNCIG +FA++ +K+     L  F F     +++P+K+  
Sbjct: 420 SKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDN 479

Query: 490 L 490
           L
Sbjct: 480 L 480


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  139 bits (350), Expect = 6e-33
 Identities = 96/364 (26%), Positives = 182/364 (50%), Gaps = 15/364 (4%)

Query: 130 EGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMAL 189
           E  +W + R LL+P F    LK    +  +   +++     +A +GK   +    G  ++
Sbjct: 122 EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSM 181

Query: 190 NTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIY-WLTPHGRRFLR 248
           + +   +FG     L +    +   V      ++   +   + +  ++ +LTP       
Sbjct: 182 DVITGTSFGVNIDSLNNPQDPF---VESTKKFLKFGFLDPLFLSIILFPFLTP----VFE 234

Query: 249 ACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK----LSDAD 304
           A  V+    D +    K+  + +K R   + +  LDFL +++ +++  + +    LSD +
Sbjct: 235 ALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLE 294

Query: 305 LRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMT 364
           L A+   F+F G++TT+S +S+ LY +A +P+ Q + ++E+  +L ++    +D + +M 
Sbjct: 295 LAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQME 354

Query: 365 YLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEV 424
           YL M + E+ RL+P   ++ R   K V  ++G  +P GS++ +  YALH +   W +PE 
Sbjct: 355 YLDMVVNETLRLFPVAIRLERTCKKDVE-INGVFIPKGSMVVIPTYALHHDPKYWTEPEE 413

Query: 425 FDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFS-LDPSRL 483
           F   RFS +  S   P+ + PF  GPRNCIG +FA+  MK+     L  F F     +++
Sbjct: 414 FRPERFSKKKDS-IDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQI 472

Query: 484 PIKM 487
           P+K+
Sbjct: 473 PLKL 476


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  139 bits (350), Expect = 6e-33
 Identities = 106/422 (25%), Positives = 197/422 (46%), Gaps = 45/422 (10%)

Query: 92  LNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRG--------LLVLEGPKWLQHRKLLTP 143
           L I +PD  K V  +      + Y  F   +  G        L   E  +W + R LL+P
Sbjct: 82  LVIMDPDMIKTVLVK------ECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSP 135

Query: 144 GFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTG 203
            F     K  V + ++   +++    ++A   KS ++    G   ++ +    FG     
Sbjct: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDS 195

Query: 204 LGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIY------WLTPHGRRF---LRACQVAH 254
           L +    +        L   ++L+   + + F+       +LTP        L    V H
Sbjct: 196 LNNPQDPF--------LKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTH 247

Query: 255 DHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK----LSDADLRAEVD 310
              + + R +++ L+D++       +  +DF   ++ +++  + K    LSD +L A+  
Sbjct: 248 FLKNSIERMKESRLKDKQ-------KHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300

Query: 311 TFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCI 370
             +F  +DTT++ + + +Y +A +P+ Q + +EE+  +L ++    +D L +M YL M +
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360

Query: 371 KESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVF-DSLR 429
            E+ RL+P V +V R   K +  ++G  +P G  + + IYALH +   W +PE F    R
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIE-INGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESR 419

Query: 430 FSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFS-LDPSRLPIKMP 488
           FS +N      + ++PF AGPRNCIG +FA++ +K+     L  F F     +++P+K+ 
Sbjct: 420 FSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLD 479

Query: 489 QL 490
            L
Sbjct: 480 NL 481


>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
          Length = 500

 Score =  124 bits (312), Expect = 2e-28
 Identities = 105/380 (27%), Positives = 170/380 (44%), Gaps = 28/380 (7%)

Query: 133 KWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTL 192
           +W + R+++   F    L   +  F E    +++  E KA       +   + + A++ L
Sbjct: 133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDIL 192

Query: 193 MKCTFGRGDTGLGHRDSSYYL-AVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQ 251
            K  FG         ++S  L A   L+  ++  L       + +    P  R+ LR  +
Sbjct: 193 AKAAFGM--------ETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVR 244

Query: 252 -----VAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLR 306
                +     D V R R+A  + E+V   I  +     L    GA+D       D  L 
Sbjct: 245 ESIRFLRQVGRDWVQRRREALKRGEEVPADILTQ----ILKAEEGAQD-------DEGLL 293

Query: 307 AEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYL 366
               TF   GH+T+ + +++ +  ++  PE   R + EV E++G + +  ++DLG++ YL
Sbjct: 294 DNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYL 353

Query: 367 TMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFD 426
           +  +KES RLYPP    +R L +  T +DG  +P  + +    Y + R    + DP  F+
Sbjct: 354 SQVLKESLRLYPPAWGTFRLLEEE-TLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFN 412

Query: 427 SLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIK 486
             RF       R  F + PFS G R+CIGQQFA  E+KVV A  L R EF L P +    
Sbjct: 413 PDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGL 470

Query: 487 MPQLVLRSKNGFHLHLKPLG 506
             Q  L+  +     L+P G
Sbjct: 471 QEQATLKPLDPVLCTLRPRG 490


>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  111 bits (278), Expect = 1e-24
 Identities = 111/470 (23%), Positives = 210/470 (44%), Gaps = 71/470 (15%)

Query: 86  GQFIG---FLNIYEPDYAKAV----YSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHR 138
           G ++G   F+ I EPD  K V    +S    +     +F  + +   +L L   +W + R
Sbjct: 80  GYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVR 137

Query: 139 KLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI---FCD-----VGHMALN 190
             L   F  + L   V + +++  ++L   +  A  G +FDI   +C+     V  +A  
Sbjct: 138 GALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFG 197

Query: 191 TLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRAC 250
           T +       D  + H    +   +    L++   L+SF      +  + P+  R     
Sbjct: 198 TPVDSWQAPEDPFVKHCKRFFEFCIPRPILVL---LLSFPSIMVPLARILPNKNR----- 249

Query: 251 QVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDE-DDIKLSDADLRAEV 309
              +   +++IR    AL+D++  ++    R  DFL ++L AR     + + D D+  +V
Sbjct: 250 DELNGFFNKLIRN-VIALRDQQAAEE----RRRDFLQMVLDARHSASPMGVQDFDIVRDV 304

Query: 310 DT--------------------------------FMFEGHDTTTSGISWFLYCMALYPEH 337
            +                                F+  G++  T+ +S+  Y +A  P+ 
Sbjct: 305 FSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDC 364

Query: 338 QHRCREEV---REILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFV 394
           Q +   EV   +E     +F   ++   + YL M I E+ R+YPP  +  R+ ++    +
Sbjct: 365 QEKLLREVDVFKEKHMAPEFCSLEE--GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL 422

Query: 395 DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 454
            G+ +PAG+++ M + ALH +   WP PE F+  RF+ E   +  PF ++PF AGPR+C+
Sbjct: 423 -GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL 481

Query: 455 GQQFAMSEMKVVTAMCLLRFEFSLDP-SRLPIKM-PQLVLRSKNGFHLHL 502
           G +  + E+K+     L +F F   P +++P+++  +  L  KNG ++ +
Sbjct: 482 GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKI 531


>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  111 bits (278), Expect = 1e-24
 Identities = 111/470 (23%), Positives = 210/470 (44%), Gaps = 71/470 (15%)

Query: 86  GQFIG---FLNIYEPDYAKAV----YSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHR 138
           G ++G   F+ I EPD  K V    +S    +     +F  + +   +L L   +W + R
Sbjct: 80  GYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVR 137

Query: 139 KLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI---FCD-----VGHMALN 190
             L   F  + L   V + +++  ++L   +  A  G +FDI   +C+     V  +A  
Sbjct: 138 GALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFG 197

Query: 191 TLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRAC 250
           T +       D  + H    +   +    L++   L+SF      +  + P+  R     
Sbjct: 198 TPVDSWQAPEDPFVKHCKRFFEFCIPRPILVL---LLSFPSIMVPLARILPNKNR----- 249

Query: 251 QVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDE-DDIKLSDADLRAEV 309
              +   +++IR    AL+D++  ++    R  DFL ++L AR     + + D D+  +V
Sbjct: 250 DELNGFFNKLIRN-VIALRDQQAAEE----RRRDFLQMVLDARHSASPMGVQDFDIVRDV 304

Query: 310 DT--------------------------------FMFEGHDTTTSGISWFLYCMALYPEH 337
            +                                F+  G++  T+ +S+  Y +A  P+ 
Sbjct: 305 FSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDC 364

Query: 338 QHRCREEV---REILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFV 394
           Q +   EV   +E     +F   ++   + YL M I E+ R+YPP  +  R+ ++    +
Sbjct: 365 QEKLLREVDVFKEKHMAPEFCSLEE--GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL 422

Query: 395 DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 454
            G+ +PAG+++ M + ALH +   WP PE F+  RF+ E   +  PF ++PF AGPR+C+
Sbjct: 423 -GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL 481

Query: 455 GQQFAMSEMKVVTAMCLLRFEFSLDP-SRLPIKM-PQLVLRSKNGFHLHL 502
           G +  + E+K+     L +F F   P +++P+++  +  L  KNG ++ +
Sbjct: 482 GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKI 531


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  110 bits (274), Expect = 4e-24
 Identities = 93/366 (25%), Positives = 151/366 (41%), Gaps = 16/366 (4%)

Query: 131 GPKWLQHRKLLTPGFHYDVL--KPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMA 188
           G  W+ HR+L    F Y     K + +   E T+   D  E    +G+ FD    + +  
Sbjct: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIE--TYKGRPFDFKQLITNAV 187

Query: 189 LNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGR--RF 246
            N      FG   T     D  + + +    + +      F Y+      + P G+  + 
Sbjct: 188 SNITNLIIFGERFT-YEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQL 246

Query: 247 LRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHL--DFLDILLGARDEDDIKLSDAD 304
            R   V +D   ++I +         V +K Q  +H    +LD +   +++     S  +
Sbjct: 247 FRNAAVVYDFLSRLIEKAS-------VNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKEN 299

Query: 305 LRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMT 364
           L   V   +  G +TTT+ + W +  MALYP  Q + ++E+  I+G      WDD  KM 
Sbjct: 300 LIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMP 359

Query: 365 YLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEV 424
           Y    + E  R    VP      +     V G S+P G+ +  ++Y++H +   W DPEV
Sbjct: 360 YTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEV 419

Query: 425 FDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLP 484
           F   RF   +       A +PFS G R+C+G+  A  EM +     L RF        +P
Sbjct: 420 FHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVP 479

Query: 485 IKMPQL 490
              P+L
Sbjct: 480 DLKPRL 485


>gi|239757171 PREDICTED: similar to cytochrome P450, family 4,
           subfamily F, polypeptide 2 [Homo sapiens]
          Length = 190

 Score =  102 bits (254), Expect = 8e-22
 Identities = 57/155 (36%), Positives = 88/155 (56%), Gaps = 5/155 (3%)

Query: 140 LLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKS-FDIFCDVGHMALNTLMKCTFG 198
           +L P FH+++LKPY+ +F ES  IM  KW     E  +  D+F  +  M L++L KC F 
Sbjct: 1   MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60

Query: 199 RGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTD 258
             D+    + S Y  +V +L+ L+ +R      H DF+Y+LT  GR F RAC++ HD  D
Sbjct: 61  F-DSQCQEKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFAD 119

Query: 259 QVIRERKAALQDEKVRKKIQNR---RHLDFLDILL 290
             I+E++  L  + V   +Q +   + LDF+D+LL
Sbjct: 120 AAIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLL 154


>gi|239751683 PREDICTED: similar to cytochrome P450, family 4,
           subfamily F, polypeptide 2 [Homo sapiens]
          Length = 190

 Score =  102 bits (254), Expect = 8e-22
 Identities = 57/155 (36%), Positives = 88/155 (56%), Gaps = 5/155 (3%)

Query: 140 LLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKS-FDIFCDVGHMALNTLMKCTFG 198
           +L P FH+++LKPY+ +F ES  IM  KW     E  +  D+F  +  M L++L KC F 
Sbjct: 1   MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60

Query: 199 RGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTD 258
             D+    + S Y  +V +L+ L+ +R      H DF+Y+LT  GR F RAC++ HD  D
Sbjct: 61  F-DSQCQEKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFAD 119

Query: 259 QVIRERKAALQDEKVRKKIQNR---RHLDFLDILL 290
             I+E++  L  + V   +Q +   + LDF+D+LL
Sbjct: 120 AAIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLL 154


>gi|239746187 PREDICTED: similar to cytochrome P450, family 4,
           subfamily F, polypeptide 2 [Homo sapiens]
          Length = 190

 Score =  102 bits (254), Expect = 8e-22
 Identities = 57/155 (36%), Positives = 88/155 (56%), Gaps = 5/155 (3%)

Query: 140 LLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKS-FDIFCDVGHMALNTLMKCTFG 198
           +L P FH+++LKPY+ +F ES  IM  KW     E  +  D+F  +  M L++L KC F 
Sbjct: 1   MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60

Query: 199 RGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTD 258
             D+    + S Y  +V +L+ L+ +R      H DF+Y+LT  GR F RAC++ HD  D
Sbjct: 61  F-DSQCQEKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFAD 119

Query: 259 QVIRERKAALQDEKVRKKIQNR---RHLDFLDILL 290
             I+E++  L  + V   +Q +   + LDF+D+LL
Sbjct: 120 AAIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLL 154


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score =  102 bits (253), Expect = 1e-21
 Identities = 115/466 (24%), Positives = 203/466 (43%), Gaps = 54/466 (11%)

Query: 47  PGPPTHWLFGHALEIQETGSL----DKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKA 102
           PGP +  L G  L+I   G L    D +V +  ++     +  G F   +++  P   +A
Sbjct: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFES-VHLGSPCLLEA 117

Query: 103 VY-------SRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHR-----KLLTPGFHYDVL 150
           +Y        R + K    Y  + +  G GLL+LEG  W + R     KL+ PG   +V+
Sbjct: 118 LYRTESAYPQRLEIKPWKAYRDYRKE-GYGLLILEGEDWQRVRSAFQKKLMKPG---EVM 173

Query: 151 KPYVAVFTESTRIMLDKWEEKARE-GKSFDIFCDVGHMALNT----LMKCTFGRGDTGLG 205
           K    +  E     + + +E   E G   D++ ++   +  +    L +  FG      G
Sbjct: 174 KLDNKI-NEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAG 232

Query: 206 HRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHT---DQVIR 262
               ++ +A+  +     + +V            TP         +V  DHT   D + +
Sbjct: 233 DEAVNFIMAIKTMMSTFGRMMV------------TPVELHKSLNTKVWQDHTLAWDTIFK 280

Query: 263 ERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTS 322
             KA + +    +K   +   DFL  +         +LS  +L A V        +TT +
Sbjct: 281 SVKACIDNRL--EKYSQQPSADFLCDIYHQN-----RLSKKELYAAVTELQLAAVETTAN 333

Query: 323 GISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQ 382
            + W LY ++  P+ Q +  +E++ +L +    + +DL  M YL  C+KES RL P VP 
Sbjct: 334 SLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPF 393

Query: 383 VYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFA 442
             R L K  T +   +LP G+++ ++   L  +   + D   F   R+  E   K +PFA
Sbjct: 394 TTRTLDK-ATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEK-EKINPFA 451

Query: 443 FMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPS-RLPIKM 487
            +PF  G R CIG++ A  E+++  A+C +  ++ +  +   P++M
Sbjct: 452 HLPFGVGKRMCIGRRLA--ELQLHLALCWIVRKYDIQATDNEPVEM 495


>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 3 [Homo sapiens]
          Length = 420

 Score = 99.0 bits (245), Expect = 9e-21
 Identities = 83/355 (23%), Positives = 160/355 (45%), Gaps = 43/355 (12%)

Query: 92  LNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRG--------LLVLEGPKWLQHRKLLTP 143
           L I +PD  K V  +      + Y  F   +  G        L   E  +W + R LL+P
Sbjct: 82  LVIMDPDMIKTVLVK------ECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSP 135

Query: 144 GFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTG 203
            F     K  V + ++   +++    ++A   KS ++    G   ++ +    FG     
Sbjct: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDS 195

Query: 204 LGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIY------WLTPHGRRF---LRACQVAH 254
           L +    +        L   ++L+   + + F+       +LTP        L    V H
Sbjct: 196 LNNPQDPF--------LKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTH 247

Query: 255 DHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK----LSDADLRAEVD 310
              + + R +++ L+D++       +  +DF   ++ +++  + K    LSD +L A+  
Sbjct: 248 FLKNSIERMKESRLKDKQ-------KHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300

Query: 311 TFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCI 370
             +F  +DTT++ + + +Y +A +P+ Q + +EE+  +L ++    +D L +M YL M +
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360

Query: 371 KESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVF 425
            E+ RL+P V +V R   K +  ++G  +P G  + + IYALH +   W +PE F
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIE-INGVFIPKGLAVMVPIYALHHDPKYWTEPEKF 414


>gi|225903399 cytochrome P450, family 51, subfamily A, polypeptide 1
           isoform 2 [Homo sapiens]
          Length = 404

 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 92/386 (23%), Positives = 160/386 (41%), Gaps = 38/386 (9%)

Query: 108 DPKAPDVYDFFLQWI-GRGLLV-LEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIML 165
           D  A DVY      + G+G+   +  P +L+ +K+L  G +    K +V++  + T+   
Sbjct: 25  DLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYF 84

Query: 166 DKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQR 225
           + W E   +    ++F  +  + + T   C  G+                S L   + Q 
Sbjct: 85  ESWGESGEK----NVFEALSELIILTASHCLHGKE-------------IRSQLNEKVAQL 127

Query: 226 LVSFQYHNDFIYWL------TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQN 279
                       WL       P  RR  RA +   D   + I++R+ +   EK+      
Sbjct: 128 YADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQS--QEKID----- 180

Query: 280 RRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQH 339
               D L  LL A  +D   L+D ++   +   +  G  T+++  +W  + +A     Q 
Sbjct: 181 ----DILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQK 236

Query: 340 RCREEVREILGDQ-DFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRS 398
           +C  E + + G+      +D L  +  L  CIKE+ RL PP+  + R    P T V G +
Sbjct: 237 KCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQT-VAGYT 295

Query: 399 LPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQF 458
           +P G  + +      R    W +   F+  R+  +N +    FA++PF AG   CIG+ F
Sbjct: 296 IPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENF 355

Query: 459 AMSEMKVVTAMCLLRFEFSLDPSRLP 484
           A  ++K + +  L  +EF L     P
Sbjct: 356 AYVQIKTIWSTMLRLYEFDLIDGYFP 381


>gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide 1
           isoform 1 [Homo sapiens]
          Length = 509

 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 92/386 (23%), Positives = 160/386 (41%), Gaps = 38/386 (9%)

Query: 108 DPKAPDVYDFFLQWI-GRGLLV-LEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIML 165
           D  A DVY      + G+G+   +  P +L+ +K+L  G +    K +V++  + T+   
Sbjct: 130 DLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYF 189

Query: 166 DKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQR 225
           + W E   +    ++F  +  + + T   C  G+                S L   + Q 
Sbjct: 190 ESWGESGEK----NVFEALSELIILTASHCLHGKE-------------IRSQLNEKVAQL 232

Query: 226 LVSFQYHNDFIYWL------TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQN 279
                       WL       P  RR  RA +   D   + I++R+ +   EK+      
Sbjct: 233 YADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQS--QEKID----- 285

Query: 280 RRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQH 339
               D L  LL A  +D   L+D ++   +   +  G  T+++  +W  + +A     Q 
Sbjct: 286 ----DILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQK 341

Query: 340 RCREEVREILGDQ-DFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRS 398
           +C  E + + G+      +D L  +  L  CIKE+ RL PP+  + R    P T V G +
Sbjct: 342 KCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQT-VAGYT 400

Query: 399 LPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQF 458
           +P G  + +      R    W +   F+  R+  +N +    FA++PF AG   CIG+ F
Sbjct: 401 IPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENF 460

Query: 459 AMSEMKVVTAMCLLRFEFSLDPSRLP 484
           A  ++K + +  L  +EF L     P
Sbjct: 461 AYVQIKTIWSTMLRLYEFDLIDGYFP 486


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.141    0.452 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,059,938
Number of Sequences: 37866
Number of extensions: 941376
Number of successful extensions: 2538
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 2318
Number of HSP's gapped (non-prelim): 87
length of query: 511
length of database: 18,247,518
effective HSP length: 107
effective length of query: 404
effective length of database: 14,195,856
effective search space: 5735125824
effective search space used: 5735125824
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.