Search of human proteins with 15277417

Search of human proteins with 15277417

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15277417 capping protein alpha 3 [Homo sapiens]
         (299 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|15277417 capping protein alpha 3 [Homo sapiens]                    615   e-176
gi|5453599 capping protein (actin filament) muscle Z-line, alpha...   195   5e-50
gi|5453597 F-actin capping protein alpha-1 subunit [Homo sapiens]     191   5e-49
gi|149773468 RAD51 associated protein 2 [Homo sapiens]                 32   0.89 
gi|196049380 3-hydroxy-3-methylglutaryl-Coenzyme A reductase iso...    31   1.2  
gi|4557643 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isofo...    31   1.2  
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]                    31   1.2  
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu...    31   1.5  
gi|8922430 centrosomal protein 27kDa isoform 1 [Homo sapiens]          30   2.0  
gi|22035702 synaptogyrin 4 [Homo sapiens]                              30   2.0  
gi|55770862 thyroglobulin [Homo sapiens]                               30   3.4  
gi|215599324 coiled-coil domain containing 114 isoform 2 [Homo s...    30   3.4  
gi|133922609 hypothetical protein LOC23383 [Homo sapiens]              30   3.4  
gi|194394168 centrosomal protein 27kDa isoform 2 [Homo sapiens]        29   4.4  
gi|154354979 myosin X [Homo sapiens]                                   28   7.5  
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]                28   9.8  
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                28   9.8  
gi|134152708 arginine and glutamate rich 1 [Homo sapiens]              28   9.8  

>gi|15277417 capping protein alpha 3 [Homo sapiens]
          Length = 299

 Score =  615 bits (1585), Expect = e-176
 Identities = 299/299 (100%), Positives = 299/299 (100%)

Query: 1   MTLSVLSRKDKERVIRRLLLQAPPGEFVNAFDDLCLLIRDEKLMHHQGECAGHQHCQKYS 60
           MTLSVLSRKDKERVIRRLLLQAPPGEFVNAFDDLCLLIRDEKLMHHQGECAGHQHCQKYS
Sbjct: 1   MTLSVLSRKDKERVIRRLLLQAPPGEFVNAFDDLCLLIRDEKLMHHQGECAGHQHCQKYS 60

Query: 61  VPLCIDGNPVLLSHHNVMGDYRFFDHQSKLSFKYDLLQNQLKDIQSHGIIQNEAEYLRVV 120
           VPLCIDGNPVLLSHHNVMGDYRFFDHQSKLSFKYDLLQNQLKDIQSHGIIQNEAEYLRVV
Sbjct: 61  VPLCIDGNPVLLSHHNVMGDYRFFDHQSKLSFKYDLLQNQLKDIQSHGIIQNEAEYLRVV 120

Query: 121 LLCALKLYVNDHYPKGNCNMLRKTVKSKEYLIACIEDHNYETGECWNGLWKSKWIFQVNP 180
           LLCALKLYVNDHYPKGNCNMLRKTVKSKEYLIACIEDHNYETGECWNGLWKSKWIFQVNP
Sbjct: 121 LLCALKLYVNDHYPKGNCNMLRKTVKSKEYLIACIEDHNYETGECWNGLWKSKWIFQVNP 180

Query: 181 FLTQVTGRIFVQAHFFRCVNLHIEISKDLKESLEIVNQAQLALSFARLVEEQENKFQAAV 240
           FLTQVTGRIFVQAHFFRCVNLHIEISKDLKESLEIVNQAQLALSFARLVEEQENKFQAAV
Sbjct: 181 FLTQVTGRIFVQAHFFRCVNLHIEISKDLKESLEIVNQAQLALSFARLVEEQENKFQAAV 240

Query: 241 LEELQELSNEALRKILRRDLPVTRTLIDWHRILSDLNLVMYPKLGYVIYSRSVLCNWII 299
           LEELQELSNEALRKILRRDLPVTRTLIDWHRILSDLNLVMYPKLGYVIYSRSVLCNWII
Sbjct: 241 LEELQELSNEALRKILRRDLPVTRTLIDWHRILSDLNLVMYPKLGYVIYSRSVLCNWII 299


>gi|5453599 capping protein (actin filament) muscle Z-line, alpha 2
           [Homo sapiens]
          Length = 286

 Score =  195 bits (495), Expect = 5e-50
 Identities = 98/271 (36%), Positives = 162/271 (59%), Gaps = 4/271 (1%)

Query: 6   LSRKDKERVIRRLLLQAPPGEFVNAFDDLCLLIRDEKLMHHQGECAGHQHCQKYSVPLCI 65
           LS ++K R+  + ++ APPGEF   F+D+ LL+ ++ L+      A  Q+      P+ I
Sbjct: 8   LSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKI 67

Query: 66  DG--NPVLLSHHNVMGDYRFFDHQSKLSFKYDLLQNQLKDIQSHGIIQNEAEYLRVVLLC 123
           +G  + VL++ H  +G+ +F D ++++ FK+D L+ +  D +   + +N  E  R  +  
Sbjct: 68  EGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPCEV-ENAVESWRTSVET 126

Query: 124 ALKLYVNDHYPKGNCNMLRKTVKSKEYLIACIEDHNYETGECWNGLWKSKWIFQVNPFLT 183
           AL+ YV +HYP G C +  K +  ++ +IACIE H ++    WNG W+S+W F + P  T
Sbjct: 127 ALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTT 186

Query: 184 QVTGRIFVQAHFFRCVNLHIEISKDLKESLEIVNQAQLALSFARLVEEQENKFQAAVLEE 243
           QV G + +Q H++   N+ +   KD+++SL + N+ Q A  F ++VE  EN++Q A+ E 
Sbjct: 187 QVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISEN 246

Query: 244 LQELSNEALRKILRRDLPVTRTLIDWHRILS 274
            Q +S+    K LRR LPVTRT IDW++ILS
Sbjct: 247 YQTMSDTTF-KALRRQLPVTRTKIDWNKILS 276


>gi|5453597 F-actin capping protein alpha-1 subunit [Homo sapiens]
          Length = 286

 Score =  191 bits (486), Expect = 5e-49
 Identities = 99/271 (36%), Positives = 158/271 (58%), Gaps = 4/271 (1%)

Query: 6   LSRKDKERVIRRLLLQAPPGEFVNAFDDLCLLIRDEKLMHHQGECAGHQHCQKYSVPLCI 65
           +S ++K R+  + +  APPGEF   F+D+ LL+ ++ L+      A  Q+      P+ I
Sbjct: 8   VSDEEKVRIAAKFITHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNMDQFTPVKI 67

Query: 66  DG--NPVLLSHHNVMGDYRFFDHQSKLSFKYDLLQNQLKDIQSHGIIQNEAEYLRVVLLC 123
           +G  + VL++ H  +G+ RF D ++K+SFK+D L+ +  D Q         +  R     
Sbjct: 68  EGYEDQVLITEHGDLGNSRFLDPRNKISFKFDHLRKEASDPQPEEA-DGGLKSWRESCDS 126

Query: 124 ALKLYVNDHYPKGNCNMLRKTVKSKEYLIACIEDHNYETGECWNGLWKSKWIFQVNPFLT 183
           AL+ YV DHY  G C +  KT+  ++ +IACIE H ++    WNG W+S+W F + P   
Sbjct: 127 ALRAYVKDHYSNGFCTVYAKTIDGQQTIIACIESHQFQPKNFWNGRWRSEWKFTITPPTA 186

Query: 184 QVTGRIFVQAHFFRCVNLHIEISKDLKESLEIVNQAQLALSFARLVEEQENKFQAAVLEE 243
           QV G + +Q H++   N+ +   KD+++SL + N+AQ A  F +++E  EN++Q A+ E 
Sbjct: 187 QVVGVLKIQVHYYEDGNVQLVSHKDVQDSLTVSNEAQTAKEFIKIIENAENEYQTAISEN 246

Query: 244 LQELSNEALRKILRRDLPVTRTLIDWHRILS 274
            Q +S+    K LRR LPVTRT IDW++ILS
Sbjct: 247 YQTMSDTTF-KALRRQLPVTRTKIDWNKILS 276


>gi|149773468 RAD51 associated protein 2 [Homo sapiens]
          Length = 1159

 Score = 31.6 bits (70), Expect = 0.89
 Identities = 21/83 (25%), Positives = 38/83 (45%), Gaps = 6/83 (7%)

Query: 87  QSKLSFKYDLLQNQLKDIQSHGII----QNEAEYLRVVLLCALKLYVNDHYPKGNCNMLR 142
           Q++   K   LQN  K +++  I     +N+   L     C  K  ++ +Y   NC+ ++
Sbjct: 300 QNRPDVKKQKLQNDKKTVEAENIFSKCYENDYPSLSSQNTCKRKDLISSNYC--NCSSIQ 357

Query: 143 KTVKSKEYLIACIEDHNYETGEC 165
             V+      A +E+ N+E  EC
Sbjct: 358 CNVRDSRKNFAILENANWEEAEC 380


>gi|196049380 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
           isoform 2 [Homo sapiens]
          Length = 835

 Score = 31.2 bits (69), Expect = 1.2
 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%)

Query: 185 VTGRIFVQAHFF-RCVNLHIEISKDLKESLEIVNQAQLALSFARLVEEQENK 235
           V    FV   FF  CV+L +E+S++ +E   I   +     FAR++EE+ENK
Sbjct: 201 VLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSH----FARVLEEEENK 248


>gi|4557643 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform
           1 [Homo sapiens]
          Length = 888

 Score = 31.2 bits (69), Expect = 1.2
 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%)

Query: 185 VTGRIFVQAHFF-RCVNLHIEISKDLKESLEIVNQAQLALSFARLVEEQENK 235
           V    FV   FF  CV+L +E+S++ +E   I   +     FAR++EE+ENK
Sbjct: 201 VLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSH----FARVLEEEENK 248


>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
          Length = 346

 Score = 31.2 bits (69), Expect = 1.2
 Identities = 16/64 (25%), Positives = 33/64 (51%), Gaps = 2/64 (3%)

Query: 72  LSHHNVMGDYRFFDHQSKLSFKYDLLQNQLKDIQSHGIIQNEAEYLRVVLLCALK--LYV 129
           LSH N++G    F H+S +S  +D ++  L+ I     +     +++  +L  L+   Y+
Sbjct: 69  LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128

Query: 130 NDHY 133
           + H+
Sbjct: 129 HQHW 132


>gi|116875852 HECT domain and ankyrin repeat containing, E3
           ubiquitin protein ligase 1 [Homo sapiens]
          Length = 909

 Score = 30.8 bits (68), Expect = 1.5
 Identities = 20/75 (26%), Positives = 35/75 (46%), Gaps = 10/75 (13%)

Query: 63  LCIDGN-----PVLLSHHNVMGDYRFFDHQSKLSFKYDLLQNQLKDIQSHGIIQNEAEYL 117
           LC+ G       VL+ +H      R F    +++   DL +N L+ +  H   Q+E++YL
Sbjct: 235 LCVQGGYGETCEVLIQYHP-----RLFQTIIQMTQNEDLRENMLRQVLEHLSQQSESQYL 289

Query: 118 RVVLLCALKLYVNDH 132
           +++   A     N H
Sbjct: 290 KILTSLAEVATTNGH 304


>gi|8922430 centrosomal protein 27kDa isoform 1 [Homo sapiens]
          Length = 235

 Score = 30.4 bits (67), Expect = 2.0
 Identities = 27/95 (28%), Positives = 47/95 (49%), Gaps = 9/95 (9%)

Query: 182 LTQVTGRIFVQAHFFRCVNLHIEISKDLKESLEIVNQAQLALSFARLVEEQENKFQAAVL 241
           L Q+T    +QA  ++  NL IE+ K  K++ ++V+   LA     L  +  N    AVL
Sbjct: 50  LQQITN---IQAEIYQ-KNLEIELLKLEKDTADVVHPFFLAQKCHTL--QSMNNHLEAVL 103

Query: 242 EELQELSNEALRKILRRDLPVTRTLIDWHRILSDL 276
           +E + L    L+ + + +LP+      +HR +  L
Sbjct: 104 KEKRSLRQRLLKPMCQENLPIEAV---YHRYMVHL 135


>gi|22035702 synaptogyrin 4 [Homo sapiens]
          Length = 234

 Score = 30.4 bits (67), Expect = 2.0
 Identities = 21/66 (31%), Positives = 36/66 (54%), Gaps = 8/66 (12%)

Query: 242 EELQELSNEALRKILRRDLPVTR------TLIDWHRILSD--LNLVMYPKLGYVIYSRSV 293
           + LQEL+N    + LRR   +TR      +LI +  +L+D   N +  P+L  ++ S SV
Sbjct: 5   KSLQELANSEAVQFLRRPKTITRVFEGVFSLIVFSSLLTDGYQNKMESPQLHCILNSNSV 64

Query: 294 LCNWII 299
            C++ +
Sbjct: 65  ACSFAV 70


>gi|55770862 thyroglobulin [Homo sapiens]
          Length = 2768

 Score = 29.6 bits (65), Expect = 3.4
 Identities = 17/54 (31%), Positives = 27/54 (50%), Gaps = 3/54 (5%)

Query: 128 YVNDHYPKGNCNMLRKT--VKSKEYLIACIEDHNYETGECWNGLWKSKWIFQVN 179
           Y  D  P   C + R+T  +K  +Y+  C ED +++T +C N   +S W    N
Sbjct: 24  YQVDAQPLRPCELQRETAFLKQADYVPQCAEDGSFQTVQCQND-GRSCWCVGAN 76


>gi|215599324 coiled-coil domain containing 114 isoform 2 [Homo
           sapiens]
          Length = 670

 Score = 29.6 bits (65), Expect = 3.4
 Identities = 35/142 (24%), Positives = 66/142 (46%), Gaps = 22/142 (15%)

Query: 125 LKLYVNDHYPKGNCNMLRKTVK------------SKEYLIACIEDHNYETGECWNGLWKS 172
           LKL  ND  P  + ++L K  K            S+E L+ C ED   +  +    + +S
Sbjct: 227 LKLKNNDRQP--DPDVLEKREKQAGEVAEGVWKTSQERLVLCYEDALNKLSQL---MGES 281

Query: 173 KWIFQVNPFLTQVTGRIFVQAHFFRCVNLHIE-ISKDLKESLEIVNQAQLALSFARLVEE 231
                V  +L ++  R F + +F    NL +E + +++KE  E +  A+ +     L++E
Sbjct: 282 DPDLLVQKYL-EIEERNFAEFNFINEQNLELEHVQEEIKEMQEALVSARASKDDQHLLQE 340

Query: 232 QENKFQAAVLEELQELSNEALR 253
           Q+ K    + + + ++ +EA R
Sbjct: 341 QQQK---VLQQRMDKVHSEAER 359


>gi|133922609 hypothetical protein LOC23383 [Homo sapiens]
          Length = 613

 Score = 29.6 bits (65), Expect = 3.4
 Identities = 24/84 (28%), Positives = 44/84 (52%), Gaps = 9/84 (10%)

Query: 202 HIEISKDLKESLEIVNQAQLALSFARLVEEQENKFQ------AAVLEEL--QELSNEALR 253
           H+++   L    +   QA+  L  A L+ +Q  +F+      A++L EL  QE S +A +
Sbjct: 68  HLQLGSVLYHHTKNSEQARSHLEKAWLISQQIPQFEDVKFEAASLLSELYCQENSVDAAK 127

Query: 254 KILRRDLPVTRTLIDWH-RILSDL 276
            +LR+ + +++    WH R+L  L
Sbjct: 128 PLLRKAIQISQQTPYWHCRLLFQL 151


>gi|194394168 centrosomal protein 27kDa isoform 2 [Homo sapiens]
          Length = 204

 Score = 29.3 bits (64), Expect = 4.4
 Identities = 23/87 (26%), Positives = 41/87 (47%), Gaps = 5/87 (5%)

Query: 190 FVQAHFFRCVNLHIEISKDLKESLEIVNQAQLALSFARLVEEQENKFQAAVLEELQELSN 249
           F+ +      NL IE+ K  K++ ++V+   LA     L  +  N    AVL+E + L  
Sbjct: 23  FIASGMVNQKNLEIELLKLEKDTADVVHPFFLAQKCHTL--QSMNNHLEAVLKEKRSLRQ 80

Query: 250 EALRKILRRDLPVTRTLIDWHRILSDL 276
             L+ + + +LP+      +HR +  L
Sbjct: 81  RLLKPMCQENLPIEAV---YHRYMVHL 104


>gi|154354979 myosin X [Homo sapiens]
          Length = 2058

 Score = 28.5 bits (62), Expect = 7.5
 Identities = 16/53 (30%), Positives = 29/53 (54%)

Query: 203 IEISKDLKESLEIVNQAQLALSFARLVEEQENKFQAAVLEELQELSNEALRKI 255
           +E  K+ K+  EI+   +      R+ E+QE     A L++LQE  ++ LR++
Sbjct: 878 LEKQKENKQVEEILRLEKEIEDLQRMKEQQELSLTEASLQKLQERRDQELRRL 930


>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
          Length = 1220

 Score = 28.1 bits (61), Expect = 9.8
 Identities = 18/54 (33%), Positives = 26/54 (48%)

Query: 206 SKDLKESLEIVNQAQLALSFARLVEEQENKFQAAVLEELQELSNEALRKILRRD 259
           +  LKE  EI N+ QL    +   E  + K Q   + EL++   EA R+   RD
Sbjct: 604 NNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERD 657


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 28.1 bits (61), Expect = 9.8
 Identities = 18/54 (33%), Positives = 26/54 (48%)

Query: 206 SKDLKESLEIVNQAQLALSFARLVEEQENKFQAAVLEELQELSNEALRKILRRD 259
           +  LKE  EI N+ QL    +   E  + K Q   + EL++   EA R+   RD
Sbjct: 604 NNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERD 657


>gi|134152708 arginine and glutamate rich 1 [Homo sapiens]
          Length = 273

 Score = 28.1 bits (61), Expect = 9.8
 Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 6/51 (11%)

Query: 205 ISKDLKESLEIVNQAQLALSFARLVEEQENKFQAAVLEELQELSNEALRKI 255
           + K L E LE   QA+LA   AR  EE+  +      EEL+ +  E  RKI
Sbjct: 168 MEKQLLEELERQRQAELAAQKAREEEERAKR------EELERILEENNRKI 212


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.139    0.430 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,140,777
Number of Sequences: 37866
Number of extensions: 482035
Number of successful extensions: 1630
Number of sequences better than 10.0: 18
Number of HSP's better than 10.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 1614
Number of HSP's gapped (non-prelim): 20
length of query: 299
length of database: 18,247,518
effective HSP length: 102
effective length of query: 197
effective length of database: 14,385,186
effective search space: 2833881642
effective search space used: 2833881642
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.