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Search of human proteins with 109948288
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
sapiens]
(697 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s... 1376 0.0
gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo s... 1264 0.0
gi|4507047 solute carrier family 7 (cationic amino acid transpor... 725 0.0
gi|114326550 solute carrier family 7 (cationic amino acid transp... 664 0.0
gi|114326544 solute carrier family 7 (cationic amino acid transp... 664 0.0
gi|110347453 solute carrier family 7 (cationic amino acid transp... 465 e-131
gi|181337167 solute carrier family 7 (cationic amino acid transp... 443 e-124
gi|187423910 solute carrier family 7, member 9 [Homo sapiens] 100 6e-21
gi|7657591 solute carrier family 7, member 9 [Homo sapiens] 100 6e-21
gi|33286428 solute carrier family 7 (cationic amino acid transpo... 97 4e-20
gi|71979932 solute carrier family 7 (cationic amino acid transpo... 97 7e-20
gi|7657683 solute carrier family 7, (cationic amino acid transpo... 91 4e-18
gi|186910308 solute carrier family 7 member 7 [Homo sapiens] 89 1e-17
gi|186910306 solute carrier family 7 member 7 [Homo sapiens] 89 1e-17
gi|186910304 solute carrier family 7 member 7 [Homo sapiens] 89 1e-17
gi|115648063 solute carrier family 7 (cationic amino acid transp... 84 3e-16
gi|115648022 solute carrier family 7 (cationic amino acid transp... 84 3e-16
gi|9790235 solute carrier family 7, member 10 [Homo sapiens] 79 1e-14
gi|71999149 solute carrier family 7, (cationic amino acid transp... 61 3e-09
gi|33286430 solute carrier family 7 (cationic amino acid transpo... 58 3e-08
gi|225579067 solute carrier family 12, member 4 isoform e [Homo ... 51 4e-06
gi|225579065 solute carrier family 12, member 4 isoform d [Homo ... 51 4e-06
gi|225579063 solute carrier family 12, member 4 isoform c [Homo ... 51 4e-06
gi|225579061 solute carrier family 12, member 4 isoform b [Homo ... 51 4e-06
gi|4827006 solute carrier family 12, member 4 isoform a [Homo sa... 51 4e-06
gi|31881740 solute carrier family 12 (potassium/chloride transpo... 49 2e-05
gi|38569457 solute carrier family 12, member 8 [Homo sapiens] 49 2e-05
gi|110224458 solute carrier family 12, member 6 isoform e [Homo ... 47 6e-05
gi|110224456 solute carrier family 12, member 6 isoform d [Homo ... 47 6e-05
gi|110224454 solute carrier family 12, member 6 isoform c [Homo ... 47 6e-05
>gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
sapiens]
Length = 697
Score = 1376 bits (3562), Expect = 0.0
Identities = 697/697 (100%), Positives = 697/697 (100%)
Query: 1 MKIETSGYNSDKLICRGFIGTPAPPVCDSKFLLSPSSDVRMIPCRAALTFARCLIRRKIV 60
MKIETSGYNSDKLICRGFIGTPAPPVCDSKFLLSPSSDVRMIPCRAALTFARCLIRRKIV
Sbjct: 1 MKIETSGYNSDKLICRGFIGTPAPPVCDSKFLLSPSSDVRMIPCRAALTFARCLIRRKIV 60
Query: 61 TLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASV 120
TLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASV
Sbjct: 61 TLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASV 120
Query: 121 MAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDE 180
MAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDE
Sbjct: 121 MAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDE 180
Query: 181 LLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNIL 240
LLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNIL
Sbjct: 181 LLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNIL 240
Query: 241 VLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAG 300
VLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAG
Sbjct: 241 VLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAG 300
Query: 301 AATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLD 360
AATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLD
Sbjct: 301 AATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLD 360
Query: 361 EKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARV 420
EKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARV
Sbjct: 361 EKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARV 420
Query: 421 SKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLSYD 480
SKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLSYD
Sbjct: 421 SKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLSYD 480
Query: 481 QPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLFCPSLLPTQQSASLVSFLVGFL 540
QPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLFCPSLLPTQQSASLVSFLVGFL
Sbjct: 481 QPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLFCPSLLPTQQSASLVSFLVGFL 540
Query: 541 AFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAIVLTIWRLPQNQQKVAFMVPFL 600
AFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAIVLTIWRLPQNQQKVAFMVPFL
Sbjct: 541 AFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAIVLTIWRLPQNQQKVAFMVPFL 600
Query: 601 PFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFSYGIRHSLEGHLRDENNEEDAY 660
PFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFSYGIRHSLEGHLRDENNEEDAY
Sbjct: 601 PFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFSYGIRHSLEGHLRDENNEEDAY 660
Query: 661 PDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF 697
PDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF
Sbjct: 661 PDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF 697
>gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo
sapiens]
Length = 658
Score = 1264 bits (3271), Expect = 0.0
Identities = 637/658 (96%), Positives = 652/658 (99%), Gaps = 1/658 (0%)
Query: 41 MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA 100
MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA
Sbjct: 1 MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA 60
Query: 101 KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI 160
KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI
Sbjct: 61 KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI 120
Query: 161 LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLL 220
LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLL
Sbjct: 121 LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLL 180
Query: 221 SFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENG 280
SFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENG
Sbjct: 181 SFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENG 240
Query: 281 TSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCF 340
TSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCF
Sbjct: 241 TSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCF 300
Query: 341 MAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPL 400
MAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGS+FP+
Sbjct: 301 MAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPM 360
Query: 401 PRILFAMARDGLLFRFLARV-SKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLM 459
PR+++AMA DGLLF+ LA++ SK ++P+ ATL++G ++ALMAFLFDLKALVDMMSIGTLM
Sbjct: 361 PRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLM 420
Query: 460 AYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLF 519
AYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLF
Sbjct: 421 AYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLF 480
Query: 520 CPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAI 579
CPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAI
Sbjct: 481 CPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAI 540
Query: 580 VLTIWRLPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFS 639
VLTIWRLPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFS
Sbjct: 541 VLTIWRLPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFS 600
Query: 640 YGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF 697
YGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF
Sbjct: 601 YGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF 658
>gi|4507047 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 1 [Homo sapiens]
Length = 629
Score = 725 bits (1871), Expect = 0.0
Identities = 371/615 (60%), Positives = 471/615 (76%), Gaps = 12/615 (1%)
Query: 44 CRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKAD 103
C+ L + ++RRK+V S E+T+L RCL+T DL+ALGVGSTLGAGVYVLAG VA+ +
Sbjct: 3 CKVLLNIGQQMLRRKVVDC-SREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVAREN 61
Query: 104 SGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSY 163
+GP+IV+SFLIAALASV+AGLCY EFGARVPKTGSAYLY+YVTVGELWAFITGWNLILSY
Sbjct: 62 AGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSY 121
Query: 164 VIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTG-LAEYPDFFAVCLILLLAGLLSF 222
+IGTSSVARAWS TFDEL+ + IG+F RT+ +N G LAE PD FAV +IL+L GLL+
Sbjct: 122 IIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTL 181
Query: 223 GVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISAS-AREPPSENGT 281
GVKESA VNK+FT +N+LVL F+MV+GFVKG+V NW+++EE N S ++ G
Sbjct: 182 GVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGK 241
Query: 282 SIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFM 341
G GGFMP+GF+G L+GAATCFYAFVGFDCIATTGEEV+NPQKAIP+GIV SLL+CF+
Sbjct: 242 P--GVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFI 299
Query: 342 AYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLP 401
AYFGVSAALTLMMPY+ LD SPLP AF++VGW AKY VA GSLCALS SLLGSMFP+P
Sbjct: 300 AYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMP 359
Query: 402 RILFAMARDGLLFRFLARVSKR-QSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMA 460
R+++AMA DGLLF+FLA V+ R ++P+ ATL +G ++A+MAFLFDLK LVD+MSIGTL+A
Sbjct: 360 RVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLA 419
Query: 461 YSLVAACVLILRY---QPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTML-QRQGFSMR 516
YSLVAACVL+LRY QP L Y S E D + + S ++SQ+ L + + FS++
Sbjct: 420 YSLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQN-ELASTNDSQLGFLPEAEMFSLK 478
Query: 517 TLFCP-SLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVL 575
T+ P ++ P++ S +V+ +A L++ ++T G A+T+ W++ LLA +L
Sbjct: 479 TILSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALL 538
Query: 576 FVAIVLTIWRLPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFL 635
+ IWR P+++ K++F VPFLP LP SI VN+YLM+QL TWVRF++WM IGF+
Sbjct: 539 CAVVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFI 598
Query: 636 IYFSYGIRHSLEGHL 650
IYF YG+ HS E L
Sbjct: 599 IYFGYGLWHSEEASL 613
>gi|114326550 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 664 bits (1713), Expect = 0.0
Identities = 357/611 (58%), Positives = 449/611 (73%), Gaps = 25/611 (4%)
Query: 42 IPCRAALTFARCLIRRKIVTLDS-LEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA 100
+P +A F + L+RR+ TL+S + +T+L RCLST+DL+ALGVGSTLGAGVYVLAGEVA
Sbjct: 1 MPWQAFRRFGQKLVRRR--TLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVA 58
Query: 101 KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI 160
K +GPSIV+ FL+AAL+SV+AGLCYAEFGARVP++GSAYLY+YVTVGELWAF TGWNLI
Sbjct: 59 KDKAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLI 118
Query: 161 LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTG-LAEYPDFFAVCLILLLAGL 219
LSYVIGT+SVARAWS FD L+ I + L+ ++ LAEYPDFFA+ L+LLL GL
Sbjct: 119 LSYVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGL 178
Query: 220 LSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSEN 279
L+ G ESA V KVFT VN+LVL FVM++GFVKG+V NWK++EE + A + S
Sbjct: 179 LALGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYS-- 236
Query: 280 GTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVC 339
G+GGF+P+GF G L GAATCFYAFVGFDCIATTGEE +NPQ++IP+GIV SL VC
Sbjct: 237 -LGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVC 295
Query: 340 FMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFP 399
F+AYF VS+ALTLMMPYY L +SPLP AF Y+GW PA+YVVA GSLCALSTSLLGSMFP
Sbjct: 296 FLAYFAVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFP 355
Query: 400 LPRILFAMARDGLLFRFLARV-SKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTL 458
+PR+++AMA DGLLFR LAR+ + ++P+ AT+ +G+I+A MAFLF L LVD+MSIGTL
Sbjct: 356 MPRVIYAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTL 415
Query: 459 MAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTL 518
+AYSLV+ CVLILRYQP DQ + E+ L +T++SE ++ L
Sbjct: 416 LAYSLVSICVLILRYQP----DQETKTGEEVEL-QEEAITTESEK---------LTLWGL 461
Query: 519 FCP-SLLPTQQSASLVSFLVGFLAFLVLGLS-VLTTYGVHAITRLEAWSLALLALFLVLF 576
F P + +PT S +V LA L+ L VL + V ++ W+ A++ L L+L
Sbjct: 462 FFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWT-AVVVLLLLLI 520
Query: 577 VAIVLTIWRLPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLI 636
+ I++ IWR PQ+ + F VP LP LP SI VNIYLM+Q++A TW RF +WM IGF I
Sbjct: 521 IGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAI 580
Query: 637 YFSYGIRHSLE 647
YF YGI+HSLE
Sbjct: 581 YFGYGIQHSLE 591
>gi|114326544 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 664 bits (1713), Expect = 0.0
Identities = 357/611 (58%), Positives = 449/611 (73%), Gaps = 25/611 (4%)
Query: 42 IPCRAALTFARCLIRRKIVTLDS-LEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA 100
+P +A F + L+RR+ TL+S + +T+L RCLST+DL+ALGVGSTLGAGVYVLAGEVA
Sbjct: 1 MPWQAFRRFGQKLVRRR--TLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVA 58
Query: 101 KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI 160
K +GPSIV+ FL+AAL+SV+AGLCYAEFGARVP++GSAYLY+YVTVGELWAF TGWNLI
Sbjct: 59 KDKAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLI 118
Query: 161 LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTG-LAEYPDFFAVCLILLLAGL 219
LSYVIGT+SVARAWS FD L+ I + L+ ++ LAEYPDFFA+ L+LLL GL
Sbjct: 119 LSYVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGL 178
Query: 220 LSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSEN 279
L+ G ESA V KVFT VN+LVL FVM++GFVKG+V NWK++EE + A + S
Sbjct: 179 LALGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYS-- 236
Query: 280 GTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVC 339
G+GGF+P+GF G L GAATCFYAFVGFDCIATTGEE +NPQ++IP+GIV SL VC
Sbjct: 237 -LGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVC 295
Query: 340 FMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFP 399
F+AYF VS+ALTLMMPYY L +SPLP AF Y+GW PA+YVVA GSLCALSTSLLGSMFP
Sbjct: 296 FLAYFAVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFP 355
Query: 400 LPRILFAMARDGLLFRFLARV-SKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTL 458
+PR+++AMA DGLLFR LAR+ + ++P+ AT+ +G+I+A MAFLF L LVD+MSIGTL
Sbjct: 356 MPRVIYAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTL 415
Query: 459 MAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTL 518
+AYSLV+ CVLILRYQP DQ + E+ L +T++SE ++ L
Sbjct: 416 LAYSLVSICVLILRYQP----DQETKTGEEVEL-QEEAITTESEK---------LTLWGL 461
Query: 519 FCP-SLLPTQQSASLVSFLVGFLAFLVLGLS-VLTTYGVHAITRLEAWSLALLALFLVLF 576
F P + +PT S +V LA L+ L VL + V ++ W+ A++ L L+L
Sbjct: 462 FFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWT-AVVVLLLLLI 520
Query: 577 VAIVLTIWRLPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLI 636
+ I++ IWR PQ+ + F VP LP LP SI VNIYLM+Q++A TW RF +WM IGF I
Sbjct: 521 IGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAI 580
Query: 637 YFSYGIRHSLE 647
YF YGI+HSLE
Sbjct: 581 YFGYGIQHSLE 591
>gi|110347453 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 4 [Homo sapiens]
Length = 635
Score = 465 bits (1196), Expect = e-131
Identities = 255/600 (42%), Positives = 370/600 (61%), Gaps = 48/600 (8%)
Query: 63 DSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMA 122
DS +T L RCLST+DL LGVG +G+G+YVL G VAK +GP++++SF +AA+AS++A
Sbjct: 26 DSTMETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGAVAKEVAGPAVLLSFGVAAVASLLA 85
Query: 123 GLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELL 182
LCYAEFGARVP+TGSAYL+TYV++GELWAF+ GWN++L Y+IG ++VARAWSG D +
Sbjct: 86 ALCYAEFGARVPRTGSAYLFTYVSMGELWAFLIGWNVLLEYIIGGAAVARAWSGYLDSMF 145
Query: 183 SKQIGQFLRTYF-RMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILV 241
S I F T+ L YPDF A +ILL + +S G + S+W+N F+A+++LV
Sbjct: 146 SHSIRNFTETHVGSWQVPLLGHYPDFLAAGIILLASAFVSCGARVSSWLNHTFSAISLLV 205
Query: 242 LLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGA 301
+LF+++ GF+ NW E GGF P+GF+G +AG
Sbjct: 206 ILFIVILGFILAQPHNWSADE------------------------GGFAPFGFSGVMAGT 241
Query: 302 ATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDE 361
A+CFYAFVGFD IA + EE +NP++++P+ I SL + AY VS LTLM+P++ LD
Sbjct: 242 ASCFYAFVGFDVIAASSEEAQNPRRSVPLAIAISLAIAAGAYILVSTVLTLMVPWHSLDP 301
Query: 362 KSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVS 421
S L AF G+ A ++VAAGS+CA++T LL +F LPRI++AMA DGL F+ A V
Sbjct: 302 DSALADAFYQRGYRWAGFIVAAGSICAMNTVLLSLLFSLPRIVYAMAADGLFFQVFAHVH 361
Query: 422 KR-QSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLSYD 480
R Q PVA TL G+++A +A L DL++LV +S+GTL+AY+ VA +++LR+Q
Sbjct: 362 PRTQVPVAGTLAFGLLTAFLALLLDLESLVQFLSLGTLLAYTFVATSIIVLRFQ------ 415
Query: 481 QPKCSPEKDGLGSSPRVTSKSESQVT-MLQRQGF---------SMRTLFCPSL--LPTQQ 528
K SP +SP +K +S + LQ G ++ P L L
Sbjct: 416 --KSSPPSSPGPASPGPLTKQQSSFSDHLQLVGTVHASVPEPGELKPALRPYLGFLDGYS 473
Query: 529 SASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWS-LALLALFLVLFVAIVLTIWRLP 587
++V++ +G + + + + +G ++ L W + LL L V+F+ +L +
Sbjct: 474 PGAVVTWALGVMLASAITIGCVLVFG-NSTLHLPHWGYILLLLLTSVMFLLSLLVLGAHQ 532
Query: 588 QNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFSYGIRHSLE 647
Q ++ F +P +P +PA SI++NI LM++LS TWVRFSIW+ +G +YF YGIRHS E
Sbjct: 533 QQYREDLFQIPMVPLIPALSIVLNICLMLKLSYLTWVRFSIWLLMGLAVYFGYGIRHSKE 592
>gi|181337167 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 14 [Homo sapiens]
Length = 771
Score = 443 bits (1140), Expect = e-124
Identities = 269/679 (39%), Positives = 383/679 (56%), Gaps = 118/679 (17%)
Query: 68 TKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYA 127
TKL + L+T+DLI+LGVGS +G G+YV++G VAK +GP ++VSF+IAA+AS+++G+CYA
Sbjct: 47 TKLAQVLTTVDLISLGVGSCVGTGMYVVSGLVAKEMAGPGVIVSFIIAAVASILSGVCYA 106
Query: 128 EFGARVPKT-GSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQI 186
EFG RVPKT GSAY Y+YVTVGE AF GWNLIL Y+IGT++ A A S FD L + I
Sbjct: 107 EFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHTI 166
Query: 187 GQFLR-TYFRMNYTGLAE--YPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLL 243
+++ + +N G E YPD A+ + +++ +++ GVK S N V +N+ V +
Sbjct: 167 SRWMADSVGTLNGLGKGEESYPDLLALLIAVIVTIIVALGVKNSIGFNNVLNVLNLAVWV 226
Query: 244 FVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAAT 303
F+M+AG N W G F+P+G++G L GAAT
Sbjct: 227 FIMIAGLFFINGKYW--------------------------AEGQFLPHGWSGVLQGAAT 260
Query: 304 CFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKS 363
CFYAF+GFD IATTGEE +NP +IP I SL++C AY VS LTLM+PYY +D +S
Sbjct: 261 CFYAFIGFDIIATTGEEAKNPNTSIPYAITASLVICLTAYVSVSVILTLMVPYYTIDTES 320
Query: 364 PLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVSK- 422
PL F G+ AK+VVA GS+ L+ SLLGS+FP+PR+++AMA DGLLFRFLA VS
Sbjct: 321 PLMEMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSY 380
Query: 423 RQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLSYD-- 480
++PV A + +G ++AL+A L L+ L++MMSIGTL+AY+LV+ CVL+LRYQP D
Sbjct: 381 TETPVVACIVSGFLAALLALLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPESDIDGF 440
Query: 481 --------------------QPKCSPEKDG------------------LGSSPRVTSKSE 502
+ CSP +G LG + + KS+
Sbjct: 441 VKFLSEEHTKKKEGILADCEKEACSPVSEGDEFSGPATNTCGAKNLPSLGDNEMLIGKSD 500
Query: 503 SQVTMLQRQGFSMRTLFCPSLLPTQQSASLVSF--LVG---FLAFLVLGL----SVLTTY 553
+ + + ++ L+ L+G + + LGL T
Sbjct: 501 KSTYNVNHPNYGTVDMTTGIEADESENIYLIKLKKLIGPHYYTMRIRLGLPGKMDRPTAA 560
Query: 554 GVHAITRLEAWSLALLALFLVLFV------------------AIVL-------------T 582
H +T + +L LF+++F+ AI+L
Sbjct: 561 TGHTVT------ICVLLLFILMFIFCSFIIFGSDYISEQSWWAILLVVLMVLLISTLVFV 614
Query: 583 IWRLPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFSYGI 642
I + P+N +K+ +M P LPF+PAF++LVNIYLM++LS TW+RF++W +G LIYF YGI
Sbjct: 615 ILQQPENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAVWCFVGLLIYFGYGI 674
Query: 643 RHS-LEGHLRDENNEEDAY 660
+S LE R+E + Y
Sbjct: 675 WNSTLEISAREEALHQSTY 693
>gi|187423910 solute carrier family 7, member 9 [Homo sapiens]
Length = 487
Score = 100 bits (248), Expect = 6e-21
Identities = 92/416 (22%), Positives = 186/416 (44%), Gaps = 51/416 (12%)
Query: 68 TKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADS--GPSIVVSFLIAALASVMAGLC 125
T L + L + I++ VG+ +G+G++V V GP +++ LA++ A LC
Sbjct: 24 TSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAACGVLATLGA-LC 82
Query: 126 YAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQ 185
+AE G + K+G Y Y G + A++ W ++ VI +S A ++
Sbjct: 83 FAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLI--VIKPTSFA---------IICLS 131
Query: 186 IGQFLRTYFRMNYTGLAEYPDFFAVCL----ILLLAGLLSFGVKESAWVNKVFTAVNILV 241
+++ F Y G + P CL IL ++ + S V+ ++V +FTA +++
Sbjct: 132 FSEYVCAPF---YVG-CKPPQIVVKCLAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVI 187
Query: 242 LLFVMVAGFV---KGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTL 298
+ ++++G V +GN N+ S E + +S A NG
Sbjct: 188 VAIIIISGLVLLAQGNTKNFDNSFEGAQ-LSVGAISLAFYNG------------------ 228
Query: 299 AGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYL 358
+A+ G++ + EE+RNP + +P+ I+ + + Y ++ + +M
Sbjct: 229 ------LWAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATE 282
Query: 359 LDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLA 418
L + + V F PA ++V + + G+ F R+++ R+G + + L+
Sbjct: 283 LLQSQAVAVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLS 342
Query: 419 RVS-KRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRY 473
+S +R +P A + G+I+ + D+ +LV+ S + Y L ++++R+
Sbjct: 343 YISVRRLTPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRF 398
>gi|7657591 solute carrier family 7, member 9 [Homo sapiens]
Length = 487
Score = 100 bits (248), Expect = 6e-21
Identities = 92/416 (22%), Positives = 186/416 (44%), Gaps = 51/416 (12%)
Query: 68 TKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADS--GPSIVVSFLIAALASVMAGLC 125
T L + L + I++ VG+ +G+G++V V GP +++ LA++ A LC
Sbjct: 24 TSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAACGVLATLGA-LC 82
Query: 126 YAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQ 185
+AE G + K+G Y Y G + A++ W ++ VI +S A ++
Sbjct: 83 FAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLI--VIKPTSFA---------IICLS 131
Query: 186 IGQFLRTYFRMNYTGLAEYPDFFAVCL----ILLLAGLLSFGVKESAWVNKVFTAVNILV 241
+++ F Y G + P CL IL ++ + S V+ ++V +FTA +++
Sbjct: 132 FSEYVCAPF---YVG-CKPPQIVVKCLAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVI 187
Query: 242 LLFVMVAGFV---KGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTL 298
+ ++++G V +GN N+ S E + +S A NG
Sbjct: 188 VAIIIISGLVLLAQGNTKNFDNSFEGAQ-LSVGAISLAFYNG------------------ 228
Query: 299 AGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYL 358
+A+ G++ + EE+RNP + +P+ I+ + + Y ++ + +M
Sbjct: 229 ------LWAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATE 282
Query: 359 LDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLA 418
L + + V F PA ++V + + G+ F R+++ R+G + + L+
Sbjct: 283 LLQSQAVAVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLS 342
Query: 419 RVS-KRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRY 473
+S +R +P A + G+I+ + D+ +LV+ S + Y L ++++R+
Sbjct: 343 YISVRRLTPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRF 398
>gi|33286428 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 8 isoform a [Homo
sapiens]
Length = 535
Score = 97.4 bits (241), Expect = 4e-20
Identities = 101/395 (25%), Positives = 175/395 (44%), Gaps = 36/395 (9%)
Query: 84 VGSTLGAGVYVLA-GEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLY 142
VG+ +G+G++V G + A S ++ +++ +V+ LCYAE G +PK+G Y Y
Sbjct: 50 VGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSY 109
Query: 143 TYVTVGELWAFITGWNLIL-SYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGL 201
G L F+ W +L Y + +A +S L+ F +
Sbjct: 110 VKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFS-----------NYVLQPLFPTCFPPE 158
Query: 202 AEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKIS 261
+ A+CL LLL + V+ + V +FTA +L L +++ G V+ +
Sbjct: 159 SGLRLLAAICL-LLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWL 217
Query: 262 EEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEV 321
E KN + +EP G + F L G+ +A+ G++ + EE+
Sbjct: 218 EP--KNAFENFQEPDI----------GLVALAF---LQGS----FAYGGWNFLNYVTEEL 258
Query: 322 RNPQKAIPIGIVTSL-LVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYV 380
+P K +P I S+ LV F+ F A +T M P LL + + V F G ++
Sbjct: 259 VDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELL-ASNAVAVTFGEKLLGVMAWI 317
Query: 381 VAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVS-KRQSPVAATLTAGVISAL 439
+ + + GS+F R+ FA AR+G L LA + KR +P+ A L + + L
Sbjct: 318 MPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLL 377
Query: 440 MAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQ 474
M D+ L++ + + Y + A ++LR++
Sbjct: 378 MLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWK 412
>gi|71979932 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 5 [Homo sapiens]
Length = 507
Score = 96.7 bits (239), Expect = 7e-20
Identities = 94/414 (22%), Positives = 179/414 (43%), Gaps = 39/414 (9%)
Query: 66 EDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSI-VVSFLIAALASVMAGL 124
E L R ++ ++ +A+ VG+ +G+G++V V K P + +V + + S++ L
Sbjct: 42 EGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGAL 101
Query: 125 CYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSK 184
CYAE G + K+G Y Y G L AF+ W +L +I SS +++
Sbjct: 102 CYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELL--IIRPSS---------QYIVAL 150
Query: 185 QIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLF 244
+L E A +LLL + + VK + V F A +L L
Sbjct: 151 VFATYLLKPLFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALAL 210
Query: 245 VMVAGFV---KGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGA 301
+++ GFV KG+V+N + F GT + G + ++G
Sbjct: 211 IILLGFVQIGKGDVSNLDPNFSF--------------EGTKL-DVGNIVLALYSG----- 250
Query: 302 ATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDE 361
+A+ G++ + EE+ NP + +P+ I+ SL + + Y + A + +
Sbjct: 251 ---LFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLS 307
Query: 362 KSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVS 421
+ V F G +++ + S+ GS+F R+ F +R+G L L+ +
Sbjct: 308 SEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIH 367
Query: 422 KR-QSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQ 474
+ +PV + + V++ L AF D+ ++++ S + +L ++ LR++
Sbjct: 368 PQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHR 421
>gi|7657683 solute carrier family 7, (cationic amino acid
transporter, y+ system) member 11 [Homo sapiens]
Length = 501
Score = 90.9 bits (224), Expect = 4e-18
Identities = 98/423 (23%), Positives = 185/423 (43%), Gaps = 59/423 (13%)
Query: 66 EDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAK--ADSGPSIVVSFLIAALASVMAG 123
E +L R ++ + +++ +G+ +GAG+++ V + G S+ + + + + S+
Sbjct: 36 EKVQLKRKVTLLRGVSIIIGTIIGAGIFISPKGVLQNTGSVGMSLTI-WTVCGVLSLFGA 94
Query: 124 LCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLS 183
L YAE G + K+G Y Y G L AF+ W +L +I ++ A ++S
Sbjct: 95 LSYAELGTTIKKSGGHYTYILEVFGPLPAFVRVWVELL--IIRPAATA---------VIS 143
Query: 184 KQIGQFLRTYFRMNYTGLAEYPDFFAVCL----ILLLAGLLSFGVKESAWVNKVFTAVNI 239
G+++ F + E P+ + I ++ L S V SA + T +
Sbjct: 144 LAFGRYILEPFFIQ----CEIPELAIKLITAVGITVVMVLNSMSVSWSARIQIFLTFCKL 199
Query: 240 LVLLFVMVAG---FVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTG 296
+L ++V G +KG N+K + F S+ R P + Y YG
Sbjct: 200 TAILIIIVPGVMQLIKGQTQNFK--DAFSGRDSSITRLP-----LAFY-------YG--- 242
Query: 297 TLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYF--GVSAALTLMM 354
YA+ G+ + EEV NP+K IP+ I S+ + + Y V+ T+
Sbjct: 243 --------MYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINA 294
Query: 355 PYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALST--SLLGSMFPLPRILFAMARDGL 412
LL + + +G + +A ALS S+ G +F + R+ + +R+G
Sbjct: 295 EELLLSNAVAVTFSERLLG----NFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGH 350
Query: 413 LFRFLARVS-KRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLIL 471
L L+ + ++ +P+ A + ++ +M F DL +L++ +S + L A ++ L
Sbjct: 351 LPEILSMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYL 410
Query: 472 RYQ 474
RY+
Sbjct: 411 RYK 413
>gi|186910308 solute carrier family 7 member 7 [Homo sapiens]
Length = 511
Score = 89.4 bits (220), Expect = 1e-17
Identities = 97/414 (23%), Positives = 177/414 (42%), Gaps = 41/414 (9%)
Query: 66 EDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA--KADSGPSIVVSFLIAALASVMAG 123
E KL + +S ++ + L VG+ +G+G++V V A G S+V+ + + L SV
Sbjct: 29 EQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVI-WAVGGLFSVFGA 87
Query: 124 LCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLS 183
LCYAE G + K+G++Y Y G AFI W +L +I +S A + TF +
Sbjct: 88 LCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLL--IIEPTSQAII-AITFANYMV 144
Query: 184 KQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLL 243
+ + F + A A C+ LL ++ VK V +FT +L L+
Sbjct: 145 QPL-------FPSCFAPYAASRLLAAACICLLTFINCAY-VKWGTLVQDIFTYAKVLALI 196
Query: 244 FVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFT-GTLAGAA 302
V+VAG V+ G S + F F G +A A
Sbjct: 197 AVIVAGIVRLG------------------------QGASTHFENSFEGSSFAVGDIALAL 232
Query: 303 -TCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDE 361
+ +++ G+D + EE++NP++ +P+ I S+ + + Y + A ++ +
Sbjct: 233 YSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYTVLDMRDILA 292
Query: 362 KSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVS 421
+ V F +G +++ + L S+ R+ F +R+G L + +
Sbjct: 293 SDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGHLPDAICMIH 352
Query: 422 -KRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQ 474
+R +PV + L G+++ + + D+ L++ S L L LR++
Sbjct: 353 VERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWK 406
>gi|186910306 solute carrier family 7 member 7 [Homo sapiens]
Length = 511
Score = 89.4 bits (220), Expect = 1e-17
Identities = 97/414 (23%), Positives = 177/414 (42%), Gaps = 41/414 (9%)
Query: 66 EDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA--KADSGPSIVVSFLIAALASVMAG 123
E KL + +S ++ + L VG+ +G+G++V V A G S+V+ + + L SV
Sbjct: 29 EQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVI-WAVGGLFSVFGA 87
Query: 124 LCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLS 183
LCYAE G + K+G++Y Y G AFI W +L +I +S A + TF +
Sbjct: 88 LCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLL--IIEPTSQAII-AITFANYMV 144
Query: 184 KQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLL 243
+ + F + A A C+ LL ++ VK V +FT +L L+
Sbjct: 145 QPL-------FPSCFAPYAASRLLAAACICLLTFINCAY-VKWGTLVQDIFTYAKVLALI 196
Query: 244 FVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFT-GTLAGAA 302
V+VAG V+ G S + F F G +A A
Sbjct: 197 AVIVAGIVRLG------------------------QGASTHFENSFEGSSFAVGDIALAL 232
Query: 303 -TCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDE 361
+ +++ G+D + EE++NP++ +P+ I S+ + + Y + A ++ +
Sbjct: 233 YSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYTVLDMRDILA 292
Query: 362 KSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVS 421
+ V F +G +++ + L S+ R+ F +R+G L + +
Sbjct: 293 SDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGHLPDAICMIH 352
Query: 422 -KRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQ 474
+R +PV + L G+++ + + D+ L++ S L L LR++
Sbjct: 353 VERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWK 406
>gi|186910304 solute carrier family 7 member 7 [Homo sapiens]
Length = 511
Score = 89.4 bits (220), Expect = 1e-17
Identities = 97/414 (23%), Positives = 177/414 (42%), Gaps = 41/414 (9%)
Query: 66 EDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA--KADSGPSIVVSFLIAALASVMAG 123
E KL + +S ++ + L VG+ +G+G++V V A G S+V+ + + L SV
Sbjct: 29 EQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVI-WAVGGLFSVFGA 87
Query: 124 LCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLS 183
LCYAE G + K+G++Y Y G AFI W +L +I +S A + TF +
Sbjct: 88 LCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLL--IIEPTSQAII-AITFANYMV 144
Query: 184 KQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLL 243
+ + F + A A C+ LL ++ VK V +FT +L L+
Sbjct: 145 QPL-------FPSCFAPYAASRLLAAACICLLTFINCAY-VKWGTLVQDIFTYAKVLALI 196
Query: 244 FVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFT-GTLAGAA 302
V+VAG V+ G S + F F G +A A
Sbjct: 197 AVIVAGIVRLG------------------------QGASTHFENSFEGSSFAVGDIALAL 232
Query: 303 -TCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDE 361
+ +++ G+D + EE++NP++ +P+ I S+ + + Y + A ++ +
Sbjct: 233 YSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYTVLDMRDILA 292
Query: 362 KSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVS 421
+ V F +G +++ + L S+ R+ F +R+G L + +
Sbjct: 293 SDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGHLPDAICMIH 352
Query: 422 -KRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQ 474
+R +PV + L G+++ + + D+ L++ S L L LR++
Sbjct: 353 VERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWK 406
>gi|115648063 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 6 [Homo sapiens]
Length = 515
Score = 84.3 bits (207), Expect = 3e-16
Identities = 94/423 (22%), Positives = 173/423 (40%), Gaps = 55/423 (13%)
Query: 64 SLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA--KADSGPSIVVSFLIAALASVM 121
S E +L + +S ++ ++L VG+ +G+G++V V A G S++V + I L SV+
Sbjct: 35 SSETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIV-WAIGGLFSVV 93
Query: 122 AGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDEL 181
LCYAE G + K+G++Y Y G AFI W +L
Sbjct: 94 GALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLL-------------------- 133
Query: 182 LSKQIGQFLRTYFRMNYTGLAEYPD---------FFAVCLILLLAGLLSFGVKESAWVNK 232
+ + GQ + NY +P A I LL + VK V
Sbjct: 134 VVEPTGQAIIAITFANYIIQPSFPSCDPPYLACRLLAAACICLLTFVNCAYVKWGTRVQD 193
Query: 233 VFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPY 292
FT ++ L+ ++V G VK + SE F S+ + + + ++Y A
Sbjct: 194 TFTYAKVVALIAIIVMGLVKLCQGH---SEHFQDAFEGSSWDMGNLS-LALYSA------ 243
Query: 293 GFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTL 352
+++ G+D + EE++NP++ +P+ I S+ + + Y + A
Sbjct: 244 ------------LFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYT 291
Query: 353 MMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGL 412
++ + + V F +G + + + L S+F R+ F +R+G
Sbjct: 292 VLNISDVLSSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGH 351
Query: 413 LFRFLARVS-KRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLIL 471
L L+ + +R +P+ A L ++ + + D+ L++ S L L L
Sbjct: 352 LPDLLSMIHIERFTPIPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYL 411
Query: 472 RYQ 474
R++
Sbjct: 412 RWK 414
>gi|115648022 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 6 [Homo sapiens]
Length = 515
Score = 84.3 bits (207), Expect = 3e-16
Identities = 94/423 (22%), Positives = 173/423 (40%), Gaps = 55/423 (13%)
Query: 64 SLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA--KADSGPSIVVSFLIAALASVM 121
S E +L + +S ++ ++L VG+ +G+G++V V A G S++V + I L SV+
Sbjct: 35 SSETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIV-WAIGGLFSVV 93
Query: 122 AGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDEL 181
LCYAE G + K+G++Y Y G AFI W +L
Sbjct: 94 GALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLL-------------------- 133
Query: 182 LSKQIGQFLRTYFRMNYTGLAEYPD---------FFAVCLILLLAGLLSFGVKESAWVNK 232
+ + GQ + NY +P A I LL + VK V
Sbjct: 134 VVEPTGQAIIAITFANYIIQPSFPSCDPPYLACRLLAAACICLLTFVNCAYVKWGTRVQD 193
Query: 233 VFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPY 292
FT ++ L+ ++V G VK + SE F S+ + + + ++Y A
Sbjct: 194 TFTYAKVVALIAIIVMGLVKLCQGH---SEHFQDAFEGSSWDMGNLS-LALYSA------ 243
Query: 293 GFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTL 352
+++ G+D + EE++NP++ +P+ I S+ + + Y + A
Sbjct: 244 ------------LFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYT 291
Query: 353 MMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGL 412
++ + + V F +G + + + L S+F R+ F +R+G
Sbjct: 292 VLNISDVLSSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGH 351
Query: 413 LFRFLARVS-KRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLIL 471
L L+ + +R +P+ A L ++ + + D+ L++ S L L L
Sbjct: 352 LPDLLSMIHIERFTPIPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYL 411
Query: 472 RYQ 474
R++
Sbjct: 412 RWK 414
>gi|9790235 solute carrier family 7, member 10 [Homo sapiens]
Length = 523
Score = 79.0 bits (193), Expect = 1e-14
Identities = 86/397 (21%), Positives = 170/397 (42%), Gaps = 40/397 (10%)
Query: 84 VGSTLGAGVYVLAGEVAKADSGPSIVVS-FLIAALASVMAGLCYAEFGARVPKTGSAYLY 142
+G+ +G+G+++ V + + + +++ + + LCYAE G +PK+G Y Y
Sbjct: 50 IGNIIGSGIFISPKGVLEHSGSVGLALFVWVLGGGVTALGSLCYAELGVAIPKSGGDYAY 109
Query: 143 TYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLA 202
G L F+ W+ +L ++ +S+A ++S ++ N
Sbjct: 110 VTEIFGGLAGFLLLWSAVL--IMYPTSLA---------VISMTFSNYVLQPVFPNCIPPT 158
Query: 203 EYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFV---KGNVANWK 259
++ ++LL + S V+ + + +FT +L L ++ G + +G+ +
Sbjct: 159 TASRVLSMACLMLLTWVNSSSVRWATRIQDMFTGGKLLALSLIIGVGLLQIFQGHFEELR 218
Query: 260 ISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGE 319
S F ++ S G + F L G+ +AF G++ + E
Sbjct: 219 PSNAFAFWMTPSV---------------GHLALAF---LQGS----FAFSGWNFLNYVTE 256
Query: 320 EVRNPQKAIPIGIVTSL-LVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAK 378
E+ + +K +P I S+ LV F+ F A T M P LL + + V F G
Sbjct: 257 EMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELLSSNA-VAVTFGEKLLGYFS 315
Query: 379 YVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVSKRQ-SPVAATLTAGVIS 437
+V+ + + G +F R+ F+ AR+G L LA + R +P+ A L +
Sbjct: 316 WVMPVSVALSTFGGINGYLFTYSRLCFSGAREGHLPSLLAMIHVRHCTPIPALLVCCGAT 375
Query: 438 ALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQ 474
A++ + D L++ +S + Y + +L+LR++
Sbjct: 376 AVIMLVGDTYTLINYVSFINYLCYGVTILGLLLLRWR 412
>gi|71999149 solute carrier family 7, (cationic amino acid
transporter, y+ system) member 13 [Homo sapiens]
Length = 470
Score = 61.2 bits (147), Expect = 3e-09
Identities = 90/405 (22%), Positives = 162/405 (40%), Gaps = 56/405 (13%)
Query: 88 LGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMA---GLCYAEFGARVPKTGSAYLYTY 144
+GAG++V V A S ++ VS + A +++A LC AE P +G+ Y +
Sbjct: 27 IGAGIFVSPKGVL-AYSCMNVGVSLCVWAGCAILAMTSTLCSAEISISFPCSGAQYYFLK 85
Query: 145 VTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQ--FLRTYFRMNYTGLA 202
G AF+ W S +G+ VA GQ L Y +
Sbjct: 86 RYFGSTVAFLNLWT---SLFLGSGVVA---------------GQALLLAEYSIQPFFPSC 127
Query: 203 EYPDFFAVCL---ILLLAGLL-SFGVKESAWVNKVFTAVNILVLLFVMVAG---FVKGNV 255
P CL +L + G+L S GVKE W+ + + + +L F+ + G ++G
Sbjct: 128 SVPKLPKKCLALAMLWIVGILTSRGVKEVTWLQIASSVLKVSILSFISLTGVVFLIRGKK 187
Query: 256 ANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIA 315
N E F A + + + ++A+ G C
Sbjct: 188 EN---VERFQNAFDAELPD-------------------ISHLIQAIFQGYFAYSGGACFT 225
Query: 316 TTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAA-LTLMMPYYLLDEKSPLPVAFEYVGW 374
E++ P+ IP I T+L + + Y V+ + LT++ P +L + + + + +
Sbjct: 226 LIAGELKKPRTTIPKCIFTALPLVTVVYLLVNISYLTVLTPREILSSDA-VAITWADRAF 284
Query: 375 GPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVSKRQSPVAATLTAG 434
+++ +L ++LL S+F R ++ +++G L ++ SP A L
Sbjct: 285 PSLAWIMPFAISTSLFSNLLISIFKSSRPIYLASQEGQLPLLFNTLNSHSSPFTAVLLLV 344
Query: 435 VISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQ-PGLS 478
+ +L L L L++ + + L+ +L RYQ P LS
Sbjct: 345 TLGSLAIILTSLIDLINYIFFTGSLWSILLMIGILRRRYQEPNLS 389
>gi|33286430 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 8 isoform b [Homo
sapiens]
Length = 332
Score = 58.2 bits (139), Expect = 3e-08
Identities = 47/171 (27%), Positives = 83/171 (48%), Gaps = 3/171 (1%)
Query: 306 YAFVGFDCIATTGEEVRNPQKAIPIGIVTSL-LVCFMAYFGVSAALTLMMPYYLLDEKSP 364
+A+ G++ + EE+ +P K +P I S+ LV F+ F A +T M P LL +
Sbjct: 40 FAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNA- 98
Query: 365 LPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVS-KR 423
+ V F G +++ + + GS+F R+ FA AR+G L LA + KR
Sbjct: 99 VAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKR 158
Query: 424 QSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQ 474
+P+ A L + + LM D+ L++ + + Y + A ++LR++
Sbjct: 159 CTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWK 209
>gi|225579067 solute carrier family 12, member 4 isoform e [Homo
sapiens]
Length = 1054
Score = 50.8 bits (120), Expect = 4e-06
Identities = 47/187 (25%), Positives = 82/187 (43%), Gaps = 16/187 (8%)
Query: 298 LAGAATCFYAFVGFDCIATTG--------EEVRNPQKAIPIGIVTSLLVCFMAYFGVSAA 349
+A AT F VG + TG ++R+ QK+IP+G + +++ + YF
Sbjct: 382 VADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVL 441
Query: 350 LTLMMPYYLLDEKSPLPVAFEYV----GWGPAKYVVAAGSLCALSTSLLGSMFPLPRILF 405
+ +L +K V+ V W P+ +V+ GS + + L S+ PR+L
Sbjct: 442 FGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQ 500
Query: 406 AMARDGLL--FRFLARVSKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSL 463
A+A+D ++ R P A L +I+ L + L + ++S+ LM Y
Sbjct: 501 AIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLF 560
Query: 464 V-AACVL 469
V AC +
Sbjct: 561 VNLACAV 567
>gi|225579065 solute carrier family 12, member 4 isoform d [Homo
sapiens]
Length = 1079
Score = 50.8 bits (120), Expect = 4e-06
Identities = 47/187 (25%), Positives = 82/187 (43%), Gaps = 16/187 (8%)
Query: 298 LAGAATCFYAFVGFDCIATTG--------EEVRNPQKAIPIGIVTSLLVCFMAYFGVSAA 349
+A AT F VG + TG ++R+ QK+IP+G + +++ + YF
Sbjct: 407 VADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVL 466
Query: 350 LTLMMPYYLLDEKSPLPVAFEYV----GWGPAKYVVAAGSLCALSTSLLGSMFPLPRILF 405
+ +L +K V+ V W P+ +V+ GS + + L S+ PR+L
Sbjct: 467 FGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQ 525
Query: 406 AMARDGLL--FRFLARVSKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSL 463
A+A+D ++ R P A L +I+ L + L + ++S+ LM Y
Sbjct: 526 AIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLF 585
Query: 464 V-AACVL 469
V AC +
Sbjct: 586 VNLACAV 592
>gi|225579063 solute carrier family 12, member 4 isoform c [Homo
sapiens]
Length = 1087
Score = 50.8 bits (120), Expect = 4e-06
Identities = 47/187 (25%), Positives = 82/187 (43%), Gaps = 16/187 (8%)
Query: 298 LAGAATCFYAFVGFDCIATTG--------EEVRNPQKAIPIGIVTSLLVCFMAYFGVSAA 349
+A AT F VG + TG ++R+ QK+IP+G + +++ + YF
Sbjct: 415 VADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVL 474
Query: 350 LTLMMPYYLLDEKSPLPVAFEYV----GWGPAKYVVAAGSLCALSTSLLGSMFPLPRILF 405
+ +L +K V+ V W P+ +V+ GS + + L S+ PR+L
Sbjct: 475 FGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQ 533
Query: 406 AMARDGLL--FRFLARVSKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSL 463
A+A+D ++ R P A L +I+ L + L + ++S+ LM Y
Sbjct: 534 AIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLF 593
Query: 464 V-AACVL 469
V AC +
Sbjct: 594 VNLACAV 600
>gi|225579061 solute carrier family 12, member 4 isoform b [Homo
sapiens]
Length = 1079
Score = 50.8 bits (120), Expect = 4e-06
Identities = 47/187 (25%), Positives = 82/187 (43%), Gaps = 16/187 (8%)
Query: 298 LAGAATCFYAFVGFDCIATTG--------EEVRNPQKAIPIGIVTSLLVCFMAYFGVSAA 349
+A AT F VG + TG ++R+ QK+IP+G + +++ + YF
Sbjct: 413 VADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVL 472
Query: 350 LTLMMPYYLLDEKSPLPVAFEYV----GWGPAKYVVAAGSLCALSTSLLGSMFPLPRILF 405
+ +L +K V+ V W P+ +V+ GS + + L S+ PR+L
Sbjct: 473 FGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQ 531
Query: 406 AMARDGLL--FRFLARVSKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSL 463
A+A+D ++ R P A L +I+ L + L + ++S+ LM Y
Sbjct: 532 AIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLF 591
Query: 464 V-AACVL 469
V AC +
Sbjct: 592 VNLACAV 598
>gi|4827006 solute carrier family 12, member 4 isoform a [Homo
sapiens]
Length = 1085
Score = 50.8 bits (120), Expect = 4e-06
Identities = 47/187 (25%), Positives = 82/187 (43%), Gaps = 16/187 (8%)
Query: 298 LAGAATCFYAFVGFDCIATTG--------EEVRNPQKAIPIGIVTSLLVCFMAYFGVSAA 349
+A AT F VG + TG ++R+ QK+IP+G + +++ + YF
Sbjct: 413 VADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVL 472
Query: 350 LTLMMPYYLLDEKSPLPVAFEYV----GWGPAKYVVAAGSLCALSTSLLGSMFPLPRILF 405
+ +L +K V+ V W P+ +V+ GS + + L S+ PR+L
Sbjct: 473 FGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQ 531
Query: 406 AMARDGLL--FRFLARVSKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSL 463
A+A+D ++ R P A L +I+ L + L + ++S+ LM Y
Sbjct: 532 AIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLF 591
Query: 464 V-AACVL 469
V AC +
Sbjct: 592 VNLACAV 598
>gi|31881740 solute carrier family 12 (potassium/chloride
transporters), member 9 [Homo sapiens]
Length = 914
Score = 48.5 bits (114), Expect = 2e-05
Identities = 49/176 (27%), Positives = 78/176 (44%), Gaps = 10/176 (5%)
Query: 302 ATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDE 361
A F G A E+++P +AIP+G + ++ F Y + + LL E
Sbjct: 272 AVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTLLQE 331
Query: 362 KSPLPVAFEYVGWGPAKYV-VAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLAR- 419
A W P + + A +L A +SL+G+ RIL A+ARD L LA
Sbjct: 332 DYGFFRAISL--WPPLVLIGIYATALSASMSSLIGAS----RILHALARDDLFGVILAPA 385
Query: 420 --VSKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRY 473
VS+ +P AA L + + L+ L L ++++ L+AY+ V L L +
Sbjct: 386 KVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEW 441
>gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
Length = 714
Score = 48.5 bits (114), Expect = 2e-05
Identities = 83/374 (22%), Positives = 153/374 (40%), Gaps = 70/374 (18%)
Query: 109 VVSFLI-AALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGT 167
+VSF+I AL +V++G+ E + GS +Y+ ++ + TG + L YV G
Sbjct: 77 LVSFVILVALVTVLSGIGVGERSS----IGSGGVYSMIS--SVLGGQTGGTIGLLYVFGQ 130
Query: 168 SSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKES 227
+ F E +S +G G +V ++L L G+ GVK
Sbjct: 131 CVAGAMYITGFAESISDLLG-----------LGNIWAVRGISVAVLLALLGINLAGVK-- 177
Query: 228 AWVNKVFTAVNILVLLFVMVAGFVKGNVANWK-------ISEEFLKNISASAREPPSENG 280
W+ ++ + +L LL V FV G+ + S E L+N + P E+
Sbjct: 178 -WIIRL--QLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQN-NTLPDYSPGESF 233
Query: 281 TSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTS----- 335
+++G F P TG +AG G ++R P +IP+G + +
Sbjct: 234 FTVFGV--FFPAA-TGVMAGF--------------NMGGDLREPAASIPLGSLAAVGISW 276
Query: 336 -LLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLL 394
L + F+ G + +L+ EK L ++ G + S +
Sbjct: 277 FLYIVFVFLLGAICTREALRYDFLIAEKVSL-----------MGFLFLLGLYISSLASCM 325
Query: 395 GSMFPLPRILFAMARDGLLFRFLARVSK----RQSPVAATLTAGVISALMAFLFDLKALV 450
G ++ PRIL +A++ ++ LA + + ++PVAA +++ F+ + L
Sbjct: 326 GGLYGAPRILQCIAQEKVI-PALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLA 384
Query: 451 DMMSIGTLMAYSLV 464
+++I ++ Y V
Sbjct: 385 PIVTINFMLTYVAV 398
>gi|110224458 solute carrier family 12, member 6 isoform e [Homo
sapiens]
Length = 1135
Score = 47.0 bits (110), Expect = 6e-05
Identities = 51/211 (24%), Positives = 83/211 (39%), Gaps = 21/211 (9%)
Query: 274 EPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTG--------EEVRNPQ 325
E PS + + G+ L T F VG + TG ++++ Q
Sbjct: 444 EKPSAKSSDVLGS-----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQ 498
Query: 326 KAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYV----GWGPAKYVV 381
K+IPIG + ++L Y + +L +K V V W P+ +V+
Sbjct: 499 KSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSW-PSPWVI 557
Query: 382 AAGSLCALSTSLLGSMFPLPRILFAMARDGLL--FRFLARVSKRQSPVAATLTAGVISAL 439
GS + + L S+ PR+L A+A+D ++ R P A L I+ L
Sbjct: 558 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAEL 617
Query: 440 MAFLFDLKALVDMMSIGTLMAYSLV-AACVL 469
+ L + ++S+ LM Y V AC L
Sbjct: 618 GILIASLDLVAPILSMFFLMCYLFVNLACAL 648
>gi|110224456 solute carrier family 12, member 6 isoform d [Homo
sapiens]
Length = 1141
Score = 47.0 bits (110), Expect = 6e-05
Identities = 51/211 (24%), Positives = 83/211 (39%), Gaps = 21/211 (9%)
Query: 274 EPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTG--------EEVRNPQ 325
E PS + + G+ L T F VG + TG ++++ Q
Sbjct: 450 EKPSAKSSDVLGS-----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQ 504
Query: 326 KAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYV----GWGPAKYVV 381
K+IPIG + ++L Y + +L +K V V W P+ +V+
Sbjct: 505 KSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSW-PSPWVI 563
Query: 382 AAGSLCALSTSLLGSMFPLPRILFAMARDGLL--FRFLARVSKRQSPVAATLTAGVISAL 439
GS + + L S+ PR+L A+A+D ++ R P A L I+ L
Sbjct: 564 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAEL 623
Query: 440 MAFLFDLKALVDMMSIGTLMAYSLV-AACVL 469
+ L + ++S+ LM Y V AC L
Sbjct: 624 GILIASLDLVAPILSMFFLMCYLFVNLACAL 654
>gi|110224454 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 47.0 bits (110), Expect = 6e-05
Identities = 51/211 (24%), Positives = 83/211 (39%), Gaps = 21/211 (9%)
Query: 274 EPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTG--------EEVRNPQ 325
E PS + + G+ L T F VG + TG ++++ Q
Sbjct: 400 EKPSAKSSDVLGS-----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQ 454
Query: 326 KAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYV----GWGPAKYVV 381
K+IPIG + ++L Y + +L +K V V W P+ +V+
Sbjct: 455 KSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSW-PSPWVI 513
Query: 382 AAGSLCALSTSLLGSMFPLPRILFAMARDGLL--FRFLARVSKRQSPVAATLTAGVISAL 439
GS + + L S+ PR+L A+A+D ++ R P A L I+ L
Sbjct: 514 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAEL 573
Query: 440 MAFLFDLKALVDMMSIGTLMAYSLV-AACVL 469
+ L + ++S+ LM Y V AC L
Sbjct: 574 GILIASLDLVAPILSMFFLMCYLFVNLACAL 604
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.138 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,343,743
Number of Sequences: 37866
Number of extensions: 1012123
Number of successful extensions: 3387
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 3286
Number of HSP's gapped (non-prelim): 78
length of query: 697
length of database: 18,247,518
effective HSP length: 109
effective length of query: 588
effective length of database: 14,120,124
effective search space: 8302632912
effective search space used: 8302632912
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.