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Search of human proteins with 15011880
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15011880 serine/threonine protein kinase MST4 isoform 1
[Homo sapiens]
(416 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 831 0.0
gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Hom... 654 0.0
gi|109633026 serine/threonine protein kinase MST4 isoform 3 [Hom... 640 0.0
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 598 e-171
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 581 e-166
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 566 e-161
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 313 1e-85
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 305 5e-83
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 261 6e-70
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 259 4e-69
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 259 4e-69
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 259 4e-69
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 259 4e-69
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 259 4e-69
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 259 4e-69
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 259 4e-69
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 259 4e-69
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 258 7e-69
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 254 1e-67
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 254 1e-67
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 253 2e-67
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 253 2e-67
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 253 2e-67
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 253 2e-67
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 248 7e-66
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 248 7e-66
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 248 7e-66
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 244 8e-65
gi|6005810 mitogen-activated protein kinase kinase kinase kinase... 244 8e-65
gi|145275208 myosin IIIA [Homo sapiens] 242 5e-64
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 831 bits (2146), Expect = 0.0
Identities = 416/416 (100%), Positives = 416/416 (100%)
Query: 1 MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA 60
MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA
Sbjct: 1 MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA 60
Query: 61 EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ 120
EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ
Sbjct: 61 EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ 120
Query: 121 IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV 180
IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV
Sbjct: 121 IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV 180
Query: 181 GTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLV 240
GTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLV
Sbjct: 181 GTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLV 240
Query: 241 GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS
Sbjct: 241 GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
Query: 301 DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA 360
DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA
Sbjct: 301 DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA 360
Query: 361 FAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP 416
FAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
Sbjct: 361 FAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP 416
>gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Homo
sapiens]
Length = 339
Score = 654 bits (1688), Expect = 0.0
Identities = 325/327 (99%), Positives = 327/327 (100%)
Query: 90 LKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAAN 149
++GSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAAN
Sbjct: 13 MQGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAAN 72
Query: 150 VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITA 209
VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITA
Sbjct: 73 VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITA 132
Query: 210 IELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELL 269
IELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELL
Sbjct: 133 IELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELL 192
Query: 270 KHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTV 329
KHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTV
Sbjct: 193 KHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTV 252
Query: 330 RKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAE 389
RKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAE
Sbjct: 253 RKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAE 312
Query: 390 AACPGITDKMVKKLIEKFQKCSADESP 416
AACPGITDKMVKKLIEKFQKCSADESP
Sbjct: 313 AACPGITDKMVKKLIEKFQKCSADESP 339
Score = 35.4 bits (80), Expect = 0.096
Identities = 19/34 (55%), Positives = 24/34 (70%), Gaps = 5/34 (14%)
Query: 1 MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGS 34
MAHSPVAVQVPGMQ + +L+ +E +G GS
Sbjct: 1 MAHSPVAVQVPGMQGS-----KLWIIMEYLGGGS 29
>gi|109633026 serine/threonine protein kinase MST4 isoform 3 [Homo
sapiens]
Length = 354
Score = 640 bits (1650), Expect = 0.0
Identities = 343/416 (82%), Positives = 345/416 (82%), Gaps = 62/416 (14%)
Query: 1 MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA 60
MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA
Sbjct: 1 MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA 60
Query: 61 EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ 120
EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ
Sbjct: 61 EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ 120
Query: 121 IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV 180
IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV
Sbjct: 121 IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV 180
Query: 181 GTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLV 240
GTPFWMAPEVIQQSAYDSK TA EL K + I KN+ T
Sbjct: 181 GTPFWMAPEVIQQSAYDSKRP------TAKELLKHK-------------FIVKNSKKT-- 219
Query: 241 GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
SYLTELIDRFKRWKAEGHS
Sbjct: 220 -----------------------------------------SYLTELIDRFKRWKAEGHS 238
Query: 301 DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA 360
DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA
Sbjct: 239 DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA 298
Query: 361 FAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP 416
FAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
Sbjct: 299 FAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP 354
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 598 bits (1542), Expect = e-171
Identities = 310/425 (72%), Positives = 358/425 (84%), Gaps = 17/425 (4%)
Query: 1 MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA 60
MAHSPV +PGMQN ADPEELFTKLE+IGKGSFGEVFKGIDNRTQ+VVAIKIIDLEEA
Sbjct: 1 MAHSPVQSGLPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEA 60
Query: 61 EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ 120
EDEIEDIQQEITVLSQCDS YVTKYYGSYLK +KLWIIMEYLGGGSALDLL GP DE Q
Sbjct: 61 EDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQ 120
Query: 121 IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV 180
IAT+L+EILKGLDYLHSEKKIHRDIKAANVLLSE G+VKLADFGVAGQLTDTQIKRNTFV
Sbjct: 121 IATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFV 180
Query: 181 GTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLV 240
GTPFWMAPEVI+QSAYDSKADIWSLGITAIELA+GEPP+S++HPM+VLFLIPKNNPPTL
Sbjct: 181 GTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLE 240
Query: 241 GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
G+++K KEF++ACLNK+PSFRPTAKELLKHKFI++N+KKTSYLTELIDR+KRWKAE S
Sbjct: 241 GNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAE-QS 299
Query: 301 DDESDSEGSDSESTSREN--NTHPEWSFTTVRKKPDPKKVQNGAEQ--DLVQT------- 349
D+S SE SD+E+ + + + +W F T+R+K DPK ++NGA Q DL +
Sbjct: 300 HDDSSSEDSDAETDGQASGGSDSGDWIF-TIREK-DPKNLENGALQPSDLDRNKMKDIPK 357
Query: 350 ---LSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEK 406
CLS II+P FAELK++ + +IEEL +I +AE ACPGI+D MV +L+++
Sbjct: 358 RPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQR 417
Query: 407 FQKCS 411
Q+ S
Sbjct: 418 LQRYS 422
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 581 bits (1497), Expect = e-166
Identities = 302/416 (72%), Positives = 350/416 (84%), Gaps = 18/416 (4%)
Query: 11 PGMQNNI-ADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQ 69
PG N+ ADPEELFTKLE+IGKGSFGEVFKGIDNRTQ+VVAIKIIDLEEAEDEIEDIQQ
Sbjct: 22 PGGSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQ 81
Query: 70 EITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEIL 129
EITVLSQCDS YVTKYYGSYLK +KLWIIMEYLGGGSALDLL GP DE QIAT+L+EIL
Sbjct: 82 EITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREIL 141
Query: 130 KGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 189
KGLDYLHSEKKIHRDIKAANVLLSE G+VKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE
Sbjct: 142 KGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 201
Query: 190 VIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKE 249
VI+QSAYDSKADIWSLGITAIELA+GEPP+S++HPM+VLFLIPKNNPPTL G+++K KE
Sbjct: 202 VIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKE 261
Query: 250 FIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGS 309
F++ACLNK+PSFRPTAKELLKHKFI++N+KKTSYLTELIDR+KRWKAE S D+S SE S
Sbjct: 262 FVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAE-QSHDDSSSEDS 320
Query: 310 DSESTSREN--NTHPEWSFTTVRKKPDPKKVQNGAEQ--DLVQT----------LSCLSM 355
D+E+ + + + +W F T+R+K DPK ++NGA Q DL + CLS
Sbjct: 321 DAETDGQASGGSDSGDWIF-TIREK-DPKNLENGALQPSDLDRNKMKDIPKRPFSQCLST 378
Query: 356 IITPAFAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCS 411
II+P FAELK++ + +IEEL +I +AE ACPGI+D MV +L+++ Q+ S
Sbjct: 379 IISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYS 434
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 566 bits (1459), Expect = e-161
Identities = 286/408 (70%), Positives = 335/408 (82%), Gaps = 11/408 (2%)
Query: 14 QNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITV 73
Q++ DPEELFTKL+RIGKGSFGEV+KGIDN T++VVAIKIIDLEEAEDEIEDIQQEITV
Sbjct: 10 QHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITV 69
Query: 74 LSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLD 133
LSQCDS Y+T+Y+GSYLK +KLWIIMEYLGGGSALDLL+ GP +E IAT+L+EILKGLD
Sbjct: 70 LSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLD 129
Query: 134 YLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQ 193
YLHSE+KIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI+Q
Sbjct: 130 YLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ 189
Query: 194 SAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDA 253
SAYD KADIWSLGITAIELAKGEPPNSD+HPMRVLFLIPKN+PPTL G +K FKEF++A
Sbjct: 190 SAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEA 249
Query: 254 CLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSES 313
CLNKDP FRPTAKELLKHKFI + +KKTS+LTELIDR+KRWK+EGH +ES SE SD +
Sbjct: 250 CLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHG-EESSSEDSDIDG 308
Query: 314 TSRENNTHPEWSF-TTVRKKPDPK--------KVQNGAEQDLVQTLS-CLSMIITPAFAE 363
+ + P W+F T+R P K Q AE Q S CLS ++ P F E
Sbjct: 309 EAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKPAEPVKRQPRSQCLSTLVRPVFGE 368
Query: 364 LKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCS 411
LK++ + + A+EELE + ++AE +CPGI+DK++ L+E+ Q+ S
Sbjct: 369 LKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFS 416
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 313 bits (803), Expect = 1e-85
Identities = 160/306 (52%), Positives = 213/306 (69%), Gaps = 8/306 (2%)
Query: 20 PEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 79
PEE+F LE++G+GS+G VFK I + QVVAIK + +E ++++I +EI+++ QCDS
Sbjct: 23 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES---DLQEIIKEISIMQQCDS 79
Query: 80 SYVTKYYGSYLKGSKLWIIMEYLGGGSALDL--LRAGPFDEFQIATMLKEILKGLDYLHS 137
YV KYYGSY K + LWI+MEY G GS D+ LR E +IAT+LK LKGL+YLH
Sbjct: 80 PYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 139
Query: 138 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYD 197
+KIHRDIKA N+LL+ +G KLADFGVAGQLTDT KRNT +GTPFWMAPEVIQ+ Y+
Sbjct: 140 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 199
Query: 198 SKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGD--FTKSFKEFIDACL 255
ADIWSLGIT+IE+A+G+PP +D+HPMR +F+IP N PPT ++ F +F+ CL
Sbjct: 200 CVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCL 259
Query: 256 NKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTS 315
K+P R TA +LL+H FI KN+K S L +LI KA+ H + + + E + S
Sbjct: 260 VKNPEQRATATQLLQHPFI-KNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDE 318
Query: 316 RENNTH 321
E ++H
Sbjct: 319 DELDSH 324
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 305 bits (781), Expect = 5e-83
Identities = 155/302 (51%), Positives = 213/302 (70%), Gaps = 13/302 (4%)
Query: 20 PEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 79
PEE+F LE++G+GS+G V+K I T Q+VAIK + +E ++++I +EI+++ QCDS
Sbjct: 26 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVES---DLQEIIKEISIMQQCDS 82
Query: 80 SYVTKYYGSYLKGSKLWIIMEYLGGGSALDL--LRAGPFDEFQIATMLKEILKGLDYLHS 137
+V KYYGSY K + LWI+MEY G GS D+ LR E +IAT+L+ LKGL+YLH
Sbjct: 83 PHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHF 142
Query: 138 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYD 197
+KIHRDIKA N+LL+ +G KLADFGVAGQLTDT KRNT +GTPFWMAPEVIQ+ Y+
Sbjct: 143 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 202
Query: 198 SKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGD--FTKSFKEFIDACL 255
ADIWSLGITAIE+A+G+PP +D+HPMR +F+IP N PPT ++ +F +F+ CL
Sbjct: 203 CVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCL 262
Query: 256 NKDPSFRPTAKELLKHKFIVKNSKKTSYLTELID-----RFKRWKAEGHSDDESDSEGSD 310
K P R TA +LL+H F V+++K S L +LI+ + KR +++ D+ D E S+
Sbjct: 263 VKSPEQRATATQLLQHPF-VRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSE 321
Query: 311 SE 312
+
Sbjct: 322 ED 323
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 261 bits (668), Expect = 6e-70
Identities = 149/344 (43%), Positives = 213/344 (61%), Gaps = 19/344 (5%)
Query: 11 PGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQE 70
PG + +P+E F ++RIG G++G+V+K + T ++ AIK+I LE ED +QQE
Sbjct: 3 PGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGED-FAVVQQE 61
Query: 71 ITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEIL 129
I ++ C + Y+GSYL+ KLWI ME+ GGGS D+ GP E QIA + +E L
Sbjct: 62 IIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETL 121
Query: 130 KGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 189
+GL YLHS+ K+HRDIK AN+LL++ G VKLADFGV+ Q+T T KR +F+GTP+WMAPE
Sbjct: 122 QGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPE 181
Query: 190 VI---QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNN--PPTLVG--D 242
V ++ Y+ D+W++GITAIELA+ +PP D+HPMR LFL+ K+N PP L
Sbjct: 182 VAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMK 241
Query: 243 FTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSD- 301
++ SF F+ L K+P RPTA++LL+H F+ ++ + S EL+D+ + D
Sbjct: 242 WSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTR-SLAIELLDKVNNPDHSTYHDF 300
Query: 302 DESDSEGSDS-----ESTS---RENNTHPEWSFTTVRKKPDPKK 337
D+ D E + STS RE T E +F V+ P +K
Sbjct: 301 DDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRK 344
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 259 bits (661), Expect = 4e-69
Identities = 141/320 (44%), Positives = 201/320 (62%), Gaps = 18/320 (5%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ DE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K + +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241
APEVI + YD K+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L
Sbjct: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
Query: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
++K F+ FI++CL K+ S RP ++L+KH FI + +L D R K +
Sbjct: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
Query: 301 DDESDSEGSDSESTSRENNT 320
DE++ E S SE EN++
Sbjct: 316 KDETEYEYSGSEEEEEENDS 335
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 259 bits (661), Expect = 4e-69
Identities = 141/320 (44%), Positives = 201/320 (62%), Gaps = 18/320 (5%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ DE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K + +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241
APEVI + YD K+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L
Sbjct: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
Query: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
++K F+ FI++CL K+ S RP ++L+KH FI + +L D R K +
Sbjct: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
Query: 301 DDESDSEGSDSESTSRENNT 320
DE++ E S SE EN++
Sbjct: 316 KDETEYEYSGSEEEEEENDS 335
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 259 bits (661), Expect = 4e-69
Identities = 141/320 (44%), Positives = 201/320 (62%), Gaps = 18/320 (5%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ DE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K + +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241
APEVI + YD K+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L
Sbjct: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
Query: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
++K F+ FI++CL K+ S RP ++L+KH FI + +L D R K +
Sbjct: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
Query: 301 DDESDSEGSDSESTSRENNT 320
DE++ E S SE EN++
Sbjct: 316 KDETEYEYSGSEEEEEENDS 335
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 259 bits (661), Expect = 4e-69
Identities = 141/320 (44%), Positives = 201/320 (62%), Gaps = 18/320 (5%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ DE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K + +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241
APEVI + YD K+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L
Sbjct: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
Query: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
++K F+ FI++CL K+ S RP ++L+KH FI + +L D R K +
Sbjct: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
Query: 301 DDESDSEGSDSESTSRENNT 320
DE++ E S SE EN++
Sbjct: 316 KDETEYEYSGSEEEEEENDS 335
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 259 bits (661), Expect = 4e-69
Identities = 141/320 (44%), Positives = 201/320 (62%), Gaps = 18/320 (5%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ DE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K + +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241
APEVI + YD K+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L
Sbjct: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
Query: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
++K F+ FI++CL K+ S RP ++L+KH FI + +L D R K +
Sbjct: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
Query: 301 DDESDSEGSDSESTSRENNT 320
DE++ E S SE EN++
Sbjct: 316 KDETEYEYSGSEEEEEENDS 335
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 259 bits (661), Expect = 4e-69
Identities = 141/320 (44%), Positives = 201/320 (62%), Gaps = 18/320 (5%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ DE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K + +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241
APEVI + YD K+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L
Sbjct: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
Query: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
++K F+ FI++CL K+ S RP ++L+KH FI + +L D R K +
Sbjct: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
Query: 301 DDESDSEGSDSESTSRENNT 320
DE++ E S SE EN++
Sbjct: 316 KDETEYEYSGSEEEEEENDS 335
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 259 bits (661), Expect = 4e-69
Identities = 141/320 (44%), Positives = 201/320 (62%), Gaps = 18/320 (5%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ DE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K + +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241
APEVI + YD K+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L
Sbjct: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
Query: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
++K F+ FI++CL K+ S RP ++L+KH FI + +L D R K +
Sbjct: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
Query: 301 DDESDSEGSDSESTSRENNT 320
DE++ E S SE EN++
Sbjct: 316 KDETEYEYSGSEEEEEENDS 335
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 259 bits (661), Expect = 4e-69
Identities = 141/320 (44%), Positives = 201/320 (62%), Gaps = 18/320 (5%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ DE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K + +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241
APEVI + YD K+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L
Sbjct: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
Query: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
++K F+ FI++CL K+ S RP ++L+KH FI + +L D R K +
Sbjct: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
Query: 301 DDESDSEGSDSESTSRENNT 320
DE++ E S SE EN++
Sbjct: 316 KDETEYEYSGSEEEEEENDS 335
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 258 bits (659), Expect = 7e-69
Identities = 133/283 (46%), Positives = 194/283 (68%), Gaps = 10/283 (3%)
Query: 16 NIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLS 75
++ DP + F L+R+G G++G+V+K D T ++ A+KI+ L+ +D I +QQEIT+L
Sbjct: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDD-ISSLQQEITILR 66
Query: 76 QCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDY 134
+C V Y GSYL+ +LWI ME+ GGGS ++ A GP +E QIA + +E LKGL +
Sbjct: 67 ECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHH 126
Query: 135 LHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI--- 191
LHS+ KIHRDIK AN+LL+ QGDVKLADFGV+G+LT + KR +F+GTP+WMAPEV
Sbjct: 127 LHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVE 186
Query: 192 QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNN--PPTLVGD--FTKSF 247
++ Y+ D+W+LGITAIEL + +PP +HPMR L L+ K++ PP L +T++F
Sbjct: 187 RKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNF 246
Query: 248 KEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDR 290
F+ L K+P RPTA++LL+H F + + + LT+L+D+
Sbjct: 247 HHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPR-ALLTQLLDK 288
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 254 bits (648), Expect = 1e-67
Identities = 130/297 (43%), Positives = 188/297 (63%), Gaps = 9/297 (3%)
Query: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
+P++ + ++R+G G++G+V+K + T ++ A+KII LE +D IQQEI ++ +C
Sbjct: 15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQEIFMVKECK 73
Query: 79 SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHS 137
+ Y+GSYL KLWI MEY GGGS D+ GP E QIA + +E L+GL YLH+
Sbjct: 74 HCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHT 133
Query: 138 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---QQS 194
+ K+HRDIK AN+LL++ GDVKLADFGVA ++T T KR +F+GTP+WMAPEV +
Sbjct: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNG 193
Query: 195 AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNN--PPTLVG--DFTKSFKEF 250
Y+ DIW++GITAIEL + +PP D+HPMR LFL+ K+N PP L ++ +F F
Sbjct: 194 GYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNF 253
Query: 251 IDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSE 307
+ L K+P RPTA+ LL H F+ + + EL+D+ H + D +
Sbjct: 254 VKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDD 310
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 254 bits (648), Expect = 1e-67
Identities = 130/297 (43%), Positives = 188/297 (63%), Gaps = 9/297 (3%)
Query: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
+P++ + ++R+G G++G+V+K + T ++ A+KII LE +D IQQEI ++ +C
Sbjct: 15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQEIFMVKECK 73
Query: 79 SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHS 137
+ Y+GSYL KLWI MEY GGGS D+ GP E QIA + +E L+GL YLH+
Sbjct: 74 HCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHT 133
Query: 138 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---QQS 194
+ K+HRDIK AN+LL++ GDVKLADFGVA ++T T KR +F+GTP+WMAPEV +
Sbjct: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNG 193
Query: 195 AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNN--PPTLVG--DFTKSFKEF 250
Y+ DIW++GITAIEL + +PP D+HPMR LFL+ K+N PP L ++ +F F
Sbjct: 194 GYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNF 253
Query: 251 IDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSE 307
+ L K+P RPTA+ LL H F+ + + EL+D+ H + D +
Sbjct: 254 VKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDD 310
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 253 bits (646), Expect = 2e-67
Identities = 150/383 (39%), Positives = 226/383 (59%), Gaps = 39/383 (10%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ EDE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K S +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH+ K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241
APEVI + YD ++DIWSLGITAIE+A+G PP DMHPMR LFLIP+N PP L
Sbjct: 196 APEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKS 255
Query: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
++K F +FID CL K RP ++LLK FI + +L D R + +
Sbjct: 256 KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGE 315
Query: 301 DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA 360
+E++ E S SE E+++H E + +P + N + ++
Sbjct: 316 KEETEYEYSGSE---EEDDSHGE--------EGEPSSIMNVPGESTLRR----------E 354
Query: 361 FAELKQQDENNASRNQAIEELEK 383
F L+Q++++N+ + ++L++
Sbjct: 355 FLRLQQENKSNSEALKQQQQLQQ 377
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 253 bits (646), Expect = 2e-67
Identities = 150/383 (39%), Positives = 226/383 (59%), Gaps = 39/383 (10%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ EDE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K S +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH+ K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241
APEVI + YD ++DIWSLGITAIE+A+G PP DMHPMR LFLIP+N PP L
Sbjct: 196 APEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKS 255
Query: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
++K F +FID CL K RP ++LLK FI + +L D R + +
Sbjct: 256 KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGE 315
Query: 301 DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA 360
+E++ E S SE E+++H E + +P + N + ++
Sbjct: 316 KEETEYEYSGSE---EEDDSHGE--------EGEPSSIMNVPGESTLRR----------E 354
Query: 361 FAELKQQDENNASRNQAIEELEK 383
F L+Q++++N+ + ++L++
Sbjct: 355 FLRLQQENKSNSEALKQQQQLQQ 377
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 253 bits (646), Expect = 2e-67
Identities = 150/383 (39%), Positives = 226/383 (59%), Gaps = 39/383 (10%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ EDE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K S +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH+ K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241
APEVI + YD ++DIWSLGITAIE+A+G PP DMHPMR LFLIP+N PP L
Sbjct: 196 APEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKS 255
Query: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
++K F +FID CL K RP ++LLK FI + +L D R + +
Sbjct: 256 KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGE 315
Query: 301 DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA 360
+E++ E S SE E+++H E + +P + N + ++
Sbjct: 316 KEETEYEYSGSE---EEDDSHGE--------EGEPSSIMNVPGESTLRR----------E 354
Query: 361 FAELKQQDENNASRNQAIEELEK 383
F L+Q++++N+ + ++L++
Sbjct: 355 FLRLQQENKSNSEALKQQQQLQQ 377
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 253 bits (646), Expect = 2e-67
Identities = 150/383 (39%), Positives = 226/383 (59%), Gaps = 39/383 (10%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ EDE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K S +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH+ K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241
APEVI + YD ++DIWSLGITAIE+A+G PP DMHPMR LFLIP+N PP L
Sbjct: 196 APEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKS 255
Query: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
++K F +FID CL K RP ++LLK FI + +L D R + +
Sbjct: 256 KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGE 315
Query: 301 DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA 360
+E++ E S SE E+++H E + +P + N + ++
Sbjct: 316 KEETEYEYSGSE---EEDDSHGE--------EGEPSSIMNVPGESTLRR----------E 354
Query: 361 FAELKQQDENNASRNQAIEELEK 383
F L+Q++++N+ + ++L++
Sbjct: 355 FLRLQQENKSNSEALKQQQQLQQ 377
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 248 bits (633), Expect = 7e-66
Identities = 138/319 (43%), Positives = 197/319 (61%), Gaps = 18/319 (5%)
Query: 15 NNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVL 74
+++ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ EDE E+I+ EI +L
Sbjct: 16 SSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINML 73
Query: 75 SQCDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATM 124
+ + YYG+++K S +LW++ME+ G GS DL++ E IA +
Sbjct: 74 KKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYI 133
Query: 125 LKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPF 184
+EIL+GL +LH IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+
Sbjct: 134 SREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
Query: 185 WMAPEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL 239
WMAPEVI + YD ++D+WS GITAIE+A+G PP DMHPMR LFLIP+N PP L
Sbjct: 194 WMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRL 253
Query: 240 VG-DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEG 298
++K F FI+ CL K+ RP+ ++LLKH FI + +L D R + +
Sbjct: 254 KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKR 313
Query: 299 HSDDESDSEGSDSESTSRE 317
DE++ E S SE E
Sbjct: 314 GEKDETEYEYSGSEEEEEE 332
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 248 bits (633), Expect = 7e-66
Identities = 138/319 (43%), Positives = 197/319 (61%), Gaps = 18/319 (5%)
Query: 15 NNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVL 74
+++ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ EDE E+I+ EI +L
Sbjct: 16 SSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINML 73
Query: 75 SQCDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATM 124
+ + YYG+++K S +LW++ME+ G GS DL++ E IA +
Sbjct: 74 KKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYI 133
Query: 125 LKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPF 184
+EIL+GL +LH IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+
Sbjct: 134 SREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
Query: 185 WMAPEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL 239
WMAPEVI + YD ++D+WS GITAIE+A+G PP DMHPMR LFLIP+N PP L
Sbjct: 194 WMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRL 253
Query: 240 VG-DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEG 298
++K F FI+ CL K+ RP+ ++LLKH FI + +L D R + +
Sbjct: 254 KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKR 313
Query: 299 HSDDESDSEGSDSESTSRE 317
DE++ E S SE E
Sbjct: 314 GEKDETEYEYSGSEEEEEE 332
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 248 bits (633), Expect = 7e-66
Identities = 138/319 (43%), Positives = 197/319 (61%), Gaps = 18/319 (5%)
Query: 15 NNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVL 74
+++ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ EDE E+I+ EI +L
Sbjct: 16 SSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINML 73
Query: 75 SQCDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATM 124
+ + YYG+++K S +LW++ME+ G GS DL++ E IA +
Sbjct: 74 KKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYI 133
Query: 125 LKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPF 184
+EIL+GL +LH IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+
Sbjct: 134 SREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
Query: 185 WMAPEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL 239
WMAPEVI + YD ++D+WS GITAIE+A+G PP DMHPMR LFLIP+N PP L
Sbjct: 194 WMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRL 253
Query: 240 VG-DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEG 298
++K F FI+ CL K+ RP+ ++LLKH FI + +L D R + +
Sbjct: 254 KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKR 313
Query: 299 HSDDESDSEGSDSESTSRE 317
DE++ E S SE E
Sbjct: 314 GEKDETEYEYSGSEEEEEE 332
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 244 bits (624), Expect = 8e-65
Identities = 129/312 (41%), Positives = 195/312 (62%), Gaps = 10/312 (3%)
Query: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP + + L+R+G G++GEVFK D + +VA+K++ +E +D++ +Q+EI +L C
Sbjct: 12 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP-DDDVSTLQKEILILKTCR 70
Query: 79 SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHS 137
+ + Y+GSYL KLWI ME+ G GS D+ + G E QI+ + +E+L+GL YLHS
Sbjct: 71 HANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 130
Query: 138 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQ---QS 194
+KKIHRDIK AN+L+++ G+V+LADFG++ Q+ T +R +F+GTP+WMAPEV +
Sbjct: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190
Query: 195 AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKN--NPPTL--VGDFTKSFKEF 250
Y+ DIWSLGITAIELA+ +PP D+HP+RVLFL+ K+ PP L G ++ +F F
Sbjct: 191 GYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNF 250
Query: 251 IDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKR-WKAEGHSDDESDSEGS 309
I L K P RP+A ++L H+ + + + +L+D+ K K D E +
Sbjct: 251 IKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPEL 310
Query: 310 DSESTSRENNTH 321
R +TH
Sbjct: 311 PPAIPRRIRSTH 322
>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
isoform 2 [Homo sapiens]
Length = 833
Score = 244 bits (624), Expect = 8e-65
Identities = 129/312 (41%), Positives = 195/312 (62%), Gaps = 10/312 (3%)
Query: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP + + L+R+G G++GEVFK D + +VA+K++ +E +D++ +Q+EI +L C
Sbjct: 12 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP-DDDVSTLQKEILILKTCR 70
Query: 79 SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHS 137
+ + Y+GSYL KLWI ME+ G GS D+ + G E QI+ + +E+L+GL YLHS
Sbjct: 71 HANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 130
Query: 138 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQ---QS 194
+KKIHRDIK AN+L+++ G+V+LADFG++ Q+ T +R +F+GTP+WMAPEV +
Sbjct: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190
Query: 195 AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKN--NPPTL--VGDFTKSFKEF 250
Y+ DIWSLGITAIELA+ +PP D+HP+RVLFL+ K+ PP L G ++ +F F
Sbjct: 191 GYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNF 250
Query: 251 IDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKR-WKAEGHSDDESDSEGS 309
I L K P RP+A ++L H+ + + + +L+D+ K K D E +
Sbjct: 251 IKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPEL 310
Query: 310 DSESTSRENNTH 321
R +TH
Sbjct: 311 PPAIPRRIRSTH 322
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 242 bits (617), Expect = 5e-64
Identities = 134/295 (45%), Positives = 180/295 (61%), Gaps = 20/295 (6%)
Query: 15 NNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIID-LEEAEDEIEDIQQEITV 73
+N DP + + E IGKG++G+VFK ++ + Q A+KI+D + + ++EIE +
Sbjct: 12 DNFPDPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKA 71
Query: 74 LSQCDSSYVTKYYGSYLK-----GSKLWIIMEYLGGGSALDLL-----RAGPFDEFQIAT 123
LS D V ++YG Y K G KLW+++E GGS DL+ R E IA
Sbjct: 72 LS--DHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAY 129
Query: 124 MLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTP 183
+L E L GL +LH+ K IHRD+K N+LL+ +G VKL DFGV+ QLT T+ +RNT VGTP
Sbjct: 130 ILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTP 189
Query: 184 FWMAPEVIQ-----QSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPT 238
FWMAPEVI + YD++ D WSLGITAIEL G+PP +D+HPMR LF IP+N PP
Sbjct: 190 FWMAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPK 249
Query: 239 LVGD--FTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRF 291
L ++ F +FI CL KD RPT ELL+HKFI + K L + + F
Sbjct: 250 LRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQKQLTEF 304
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,933,367
Number of Sequences: 37866
Number of extensions: 700855
Number of successful extensions: 4776
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 752
Number of HSP's successfully gapped in prelim test: 83
Number of HSP's that attempted gapping in prelim test: 2188
Number of HSP's gapped (non-prelim): 994
length of query: 416
length of database: 18,247,518
effective HSP length: 105
effective length of query: 311
effective length of database: 14,271,588
effective search space: 4438463868
effective search space used: 4438463868
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.