Search of human proteins with 150036268

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens]
         (2344 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens]               4628   0.0  
gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens]                 4597   0.0  
gi|5032281 dystrophin Dp427c isoform [Homo sapiens]                  4597   0.0  
gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]                 4597   0.0  
gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]                 4597   0.0  
gi|5032285 dystrophin Dp427l isoform [Homo sapiens]                  4597   0.0  
gi|5032283 dystrophin Dp427m isoform [Homo sapiens]                  4597   0.0  
gi|5032293 dystrophin Dp140 isoform [Homo sapiens]                   2452   0.0  
gi|5032309 dystrophin Dp140b isoform [Homo sapiens]                  2427   0.0  
gi|5032311 dystrophin Dp140ab isoform [Homo sapiens]                 2390   0.0  
gi|5032313 dystrophin Dp140bc isoform [Homo sapiens]                 1908   0.0  
gi|5032295 dystrophin Dp116 isoform [Homo sapiens]                   1907   0.0  
gi|5032307 dystrophin Dp140c isoform [Homo sapiens]                  1888   0.0  
gi|110611228 utrophin [Homo sapiens]                                 1558   0.0  
gi|5032297 dystrophin Dp71 isoform [Homo sapiens]                    1240   0.0  
gi|5032299 dystrophin Dp71b isoform [Homo sapiens]                   1214   0.0  
gi|5032301 dystrophin Dp71a isoform [Homo sapiens]                   1203   0.0  
gi|5032303 dystrophin Dp71ab isoform [Homo sapiens]                  1177   0.0  
gi|148539558 dystrophin related protein 2 [Homo sapiens]              996   0.0  
gi|5032305 dystrophin Dp40 isoform [Homo sapiens]                     693   0.0  
gi|33188443 microfilament and actin filament cross-linker protei...   251   5e-66
gi|33188445 microfilament and actin filament cross-linker protei...   251   5e-66
gi|221316624 dystonin isoform 4 [Homo sapiens]                        248   7e-65
gi|221316622 dystonin isoform 3 [Homo sapiens]                        248   7e-65
gi|221316618 dystonin isoform 2 [Homo sapiens]                        248   7e-65
gi|34577047 dystonin isoform 1 [Homo sapiens]                         248   7e-65
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]             248   7e-65
gi|42717999 dystrobrevin alpha isoform 2 [Homo sapiens]               212   3e-54
gi|42718005 dystrobrevin alpha isoform 1 [Homo sapiens]               206   2e-52
gi|42717997 dystrobrevin alpha isoform 5 [Homo sapiens]               206   2e-52

>gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens]
          Length = 2344

 Score = 4628 bits (12005), Expect = 0.0
 Identities = 2344/2344 (100%), Positives = 2344/2344 (100%)

Query: 1    MTEMILLIFFPAYFLNAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKV 60
            MTEMILLIFFPAYFLNAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKV
Sbjct: 1    MTEMILLIFFPAYFLNAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKV 60

Query: 61   DAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLF 120
            DAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLF
Sbjct: 61   DAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLF 120

Query: 121  QKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEM 180
            QKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEM
Sbjct: 121  QKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEM 180

Query: 181  VIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMN 240
            VIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMN
Sbjct: 181  VIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMN 240

Query: 241  VLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTV 300
            VLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTV
Sbjct: 241  VLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTV 300

Query: 301  LGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL 360
            LGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL
Sbjct: 301  LGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL 360

Query: 361  LDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELN 420
            LDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELN
Sbjct: 361  LDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELN 420

Query: 421  HRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNE 480
            HRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNE
Sbjct: 421  HRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNE 480

Query: 481  GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 540
            GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ
Sbjct: 481  GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 540

Query: 541  YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 600
            YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA
Sbjct: 541  YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 600

Query: 601  AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 660
            AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL
Sbjct: 601  AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 660

Query: 661  TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 720
            TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA
Sbjct: 661  TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 720

Query: 721  ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 780
            ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT
Sbjct: 721  ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 780

Query: 781  EAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL 840
            EAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL
Sbjct: 781  EAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL 840

Query: 841  QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPG 900
            QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPG
Sbjct: 841  QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPG 900

Query: 901  KEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 960
            KEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ
Sbjct: 901  KEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 960

Query: 961  WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEG 1020
            WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEG
Sbjct: 961  WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEG 1020

Query: 1021 PFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELR 1080
            PFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELR
Sbjct: 1021 PFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELR 1080

Query: 1081 AKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTE 1140
            AKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTE
Sbjct: 1081 AKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTE 1140

Query: 1141 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 1200
            LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT
Sbjct: 1141 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 1200

Query: 1201 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 1260
            SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA
Sbjct: 1201 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 1260

Query: 1261 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHM 1320
            KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHM
Sbjct: 1261 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHM 1320

Query: 1321 ITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 1380
            ITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK
Sbjct: 1321 ITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 1380

Query: 1381 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDN 1440
            ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDN
Sbjct: 1381 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDN 1440

Query: 1441 MNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAV 1500
            MNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAV
Sbjct: 1441 MNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAV 1500

Query: 1501 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 1560
            QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT
Sbjct: 1501 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 1560

Query: 1561 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 1620
            RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ
Sbjct: 1561 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 1620

Query: 1621 PVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLN 1680
            PVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLN
Sbjct: 1621 PVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLN 1680

Query: 1681 TRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTT 1740
            TRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTT
Sbjct: 1681 TRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTT 1740

Query: 1741 CWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQN 1800
            CWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQN
Sbjct: 1741 CWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQN 1800

Query: 1801 DQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKT 1860
            DQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKT
Sbjct: 1801 DQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKT 1860

Query: 1861 GIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEP 1920
            GIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEP
Sbjct: 1861 GIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEP 1920

Query: 1921 SVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI 1980
            SVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI
Sbjct: 1921 SVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI 1980

Query: 1981 IGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFR 2040
            IGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFR
Sbjct: 1981 IGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFR 2040

Query: 2041 TKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYA 2100
            TKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYA
Sbjct: 2041 TKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYA 2100

Query: 2101 SRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESE 2160
            SRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESE
Sbjct: 2101 SRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESE 2160

Query: 2161 ERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAE 2220
            ERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAE
Sbjct: 2161 ERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAE 2220

Query: 2221 AKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRS 2280
            AKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRS
Sbjct: 2221 AKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRS 2280

Query: 2281 DSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMR 2340
            DSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMR
Sbjct: 2281 DSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMR 2340

Query: 2341 EDTM 2344
            EDTM
Sbjct: 2341 EDTM 2344


>gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens]
          Length = 2341

 Score = 4597 bits (11924), Expect = 0.0
 Identities = 2328/2331 (99%), Positives = 2329/2331 (99%)

Query: 14   FLNAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ 73
            +  AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ
Sbjct: 11   YKKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ 70

Query: 74   SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 133
            SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES
Sbjct: 71   SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 130

Query: 134  KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 193
            KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ
Sbjct: 131  KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 190

Query: 194  TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL 253
            TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL
Sbjct: 191  TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL 250

Query: 254  TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS 313
            TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS
Sbjct: 251  TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS 310

Query: 314  LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 373
            LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE
Sbjct: 311  LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 370

Query: 374  DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG 433
            DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG
Sbjct: 371  DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG 430

Query: 434  KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 493
            KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL
Sbjct: 431  KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 490

Query: 494  QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 553
            QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD
Sbjct: 491  QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 550

Query: 554  DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK 613
            DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK
Sbjct: 551  DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK 610

Query: 614  RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 673
            RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
Sbjct: 611  RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 670

Query: 674  EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 733
            EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL
Sbjct: 671  EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 730

Query: 734  QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 793
            QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE
Sbjct: 731  QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 790

Query: 794  NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 853
            NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE
Sbjct: 791  NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 850

Query: 854  VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 913
            VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK
Sbjct: 851  VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 910

Query: 914  LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 973
            LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG
Sbjct: 911  LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 970

Query: 974  EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 1033
            EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA
Sbjct: 971  EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 1030

Query: 1034 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1093
            KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI
Sbjct: 1031 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1090

Query: 1094 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 1153
            GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK
Sbjct: 1091 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 1150

Query: 1154 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 1213
            SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI
Sbjct: 1151 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 1210

Query: 1214 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1273
            ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD
Sbjct: 1211 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1270

Query: 1274 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1333
            AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH
Sbjct: 1271 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1330

Query: 1334 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1393
            KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL
Sbjct: 1331 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1390

Query: 1394 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1453
            MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL
Sbjct: 1391 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1450

Query: 1454 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1513
            NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE
Sbjct: 1451 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1510

Query: 1514 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1573
            LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE
Sbjct: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1570

Query: 1574 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1633
            WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH
Sbjct: 1571 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1630

Query: 1634 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 1693
            LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR
Sbjct: 1631 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 1690

Query: 1694 VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 1753
            VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS
Sbjct: 1691 VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 1750

Query: 1754 LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 1813
            LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL
Sbjct: 1751 LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 1810

Query: 1814 TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 1873
            TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK
Sbjct: 1811 TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 1870

Query: 1874 YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 1933
            YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP
Sbjct: 1871 YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 1930

Query: 1934 EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 1993
            EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY
Sbjct: 1931 EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 1990

Query: 1994 DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 2053
            DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY
Sbjct: 1991 DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 2050

Query: 2054 LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 2113
            LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY
Sbjct: 2051 LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 2110

Query: 2114 LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 2173
            LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE
Sbjct: 2111 LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 2170

Query: 2174 EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 2233
            EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA
Sbjct: 2171 EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 2230

Query: 2234 RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 2293
            RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS
Sbjct: 2231 RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 2290

Query: 2294 QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2344
            QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 2291 QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2341


>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
          Length = 3677

 Score = 4597 bits (11923), Expect = 0.0
 Identities = 2328/2328 (100%), Positives = 2328/2328 (100%)

Query: 17   AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL 76
            AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL
Sbjct: 1350 AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL 1409

Query: 77   TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 136
            TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI
Sbjct: 1410 TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1469

Query: 137  LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 196
            LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN
Sbjct: 1470 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1529

Query: 197  PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 256
            PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR
Sbjct: 1530 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1589

Query: 257  SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN 316
            SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN
Sbjct: 1590 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN 1649

Query: 317  SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL 376
            SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL
Sbjct: 1650 SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL 1709

Query: 377  KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS 436
            KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS
Sbjct: 1710 KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS 1769

Query: 437  IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 496
            IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR
Sbjct: 1770 IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1829

Query: 497  ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 556
            ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE
Sbjct: 1830 ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 1889

Query: 557  KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR 616
            KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR
Sbjct: 1890 KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR 1949

Query: 617  EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 676
            EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL
Sbjct: 1950 EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 2009

Query: 677  LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 736
            LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA
Sbjct: 2010 LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 2069

Query: 737  LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE 796
            LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE
Sbjct: 2070 LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE 2129

Query: 797  HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK 856
            HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK
Sbjct: 2130 HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK 2189

Query: 857  QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV 916
            QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV
Sbjct: 2190 QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV 2249

Query: 917  EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE 976
            EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE
Sbjct: 2250 EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE 2309

Query: 977  AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 1036
            AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP
Sbjct: 2310 AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 2369

Query: 1037 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 1096
            DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS
Sbjct: 2370 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 2429

Query: 1097 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 1156
            PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR
Sbjct: 2430 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 2489

Query: 1157 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 1216
            VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI
Sbjct: 2490 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 2549

Query: 1217 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 1276
            QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ
Sbjct: 2550 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 2609

Query: 1277 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV 1336
            KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV
Sbjct: 2610 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV 2669

Query: 1337 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 1396
            SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ
Sbjct: 2670 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 2729

Query: 1397 WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR 1456
            WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR
Sbjct: 2730 WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR 2789

Query: 1457 SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 1516
            SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT
Sbjct: 2790 SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 2849

Query: 1517 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 1576
            KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK
Sbjct: 2850 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 2909

Query: 1577 LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK 1636
            LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK
Sbjct: 2910 LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK 2969

Query: 1637 VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 1696
            VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ
Sbjct: 2970 VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 3029

Query: 1697 LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD 1756
            LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD
Sbjct: 3030 LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD 3089

Query: 1757 LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI 1816
            LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI
Sbjct: 3090 LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI 3149

Query: 1817 YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY 1876
            YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY
Sbjct: 3150 YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY 3209

Query: 1877 LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE 1936
            LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE
Sbjct: 3210 LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE 3269

Query: 1937 AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC 1996
            AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC
Sbjct: 3270 AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC 3329

Query: 1997 QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV 2056
            QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV
Sbjct: 3330 QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV 3389

Query: 2057 QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND 2116
            QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND
Sbjct: 3390 QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND 3449

Query: 2117 SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN 2176
            SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN
Sbjct: 3450 SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN 3509

Query: 2177 RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 2236
            RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ
Sbjct: 3510 RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 3569

Query: 2237 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 2296
            ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS
Sbjct: 3570 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 3629

Query: 2297 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2344
            DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 3630 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 3677



 Score =  186 bits (473), Expect = 2e-46
 Identities = 339/1824 (18%), Positives = 721/1824 (39%), Gaps = 209/1824 (11%)

Query: 56   IADKVDAAQMP--QEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL-QD 112
            + +KV+A +    ++ +K+Q    S +  +E+M       ++ ++   Q++    +  Q 
Sbjct: 751  LKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQL 810

Query: 113  VSMKFRLFQKPAN---FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 169
            +S +    +   N   F  +LQ+ + +    +  L    T   E   ++SQL  C +   
Sbjct: 811  LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 870

Query: 170  SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 229
             LS ++ ++E +    + I  K++ + P  LD    A   H+ ++ + V  R+++L+   
Sbjct: 871  RLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIF 928

Query: 230  KLSRKMR--KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 287
                 MR  + M+ +  W+  ++ +L+           ++  +   +A Q  +++Q+  L
Sbjct: 929  DTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGL 988

Query: 288  KSI-TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 346
              + T V E  K    +     + +   +   W  ++S+  E    L E    +     +
Sbjct: 989  YYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 1048

Query: 347  VDHITKWIIQADTLLDE-------SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 399
            +  + KW+ + D  L E       SE  K Q K+   + L +++  I+P ++S  +    
Sbjct: 1049 IQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQ--CRLLVSDIQTIQPSLNSVNEGGQK 1106

Query: 400  LMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE 459
            +           +E ++ ELN ++  +  ++   K ++    LE+  S  + L E  E  
Sbjct: 1107 IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALK-GGLEKTVSLQKDLSEMHEWM 1165

Query: 460  IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDER----------------KR 503
             Q      E DF     ++ +  V+E+ +  +  QQ+    +                 +
Sbjct: 1166 TQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1225

Query: 504  EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 563
            E +K + + L T +  L    + + K   E+   W++     +   K L+++E KL +  
Sbjct: 1226 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTE 1285

Query: 564  E-PRDERKIKEI----DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-LSKRWRE 617
              P    +I E+    +  ++  ++  N +R  A+ L++ G    +   +++  + RWRE
Sbjct: 1286 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1345

Query: 618  IESKFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 676
            +  +  + ++L    I + +E E  + + ++    I    + Y+ +    +Q   E +++
Sbjct: 1346 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI 1405

Query: 677  LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 736
             +          DL   E SL+ +K   Q           K+ A             Q  
Sbjct: 1406 QS----------DLTSHEISLEEMKKHNQ----------GKEAA-------------QRV 1432

Query: 737  LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL--RKTQIPEN 794
            LSQ+D   +K+    +D   +F R  +K   F   ++     L E +  L   +T+  E 
Sbjct: 1433 LSQIDVAQKKL----QDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1487

Query: 795  WEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 854
                    +   L   + + ++ V  +  TG +I+Q+    +   L E++ +L L + E+
Sbjct: 1488 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1547

Query: 855  CKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVK 913
              ++++RK++LE+   +  + ++++N    WL   D  +       G    L  ++   K
Sbjct: 1548 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGK 1607

Query: 914  LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 973
               +E+  ++  LK + E G  +     +  +++  +E+KL   N  WI V+        
Sbjct: 1608 ATQKEIEKQKVHLKSITEVGEAL---KTVLGKKETLVEDKLSLLNSNWIAVT-------S 1657

Query: 974  EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV-QETEIAVQ 1032
              E  +  L + +K +E  ++ ++H+  W+      L+   +   +   DV +  +  + 
Sbjct: 1658 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELN 1717

Query: 1033 AKQPDVEEILSKGQHLYKEK--PATQPVKRKLEDLSSEWKAVNRLLQELRAKQP--DLAP 1088
              +P V+    +  +L   +     + V+ ++ +L+  + A++  ++  +A  P  +L  
Sbjct: 1718 DIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQ 1777

Query: 1089 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 1148
              + I          + Q V  KE   +K     +       L   +     +TD     
Sbjct: 1778 FNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKRE 1837

Query: 1149 DQVIKSQRVMV--GDLEDINEMIIKQKATM-QDLEQRRPQLEELITAAQNLKNK-TSNQE 1204
            +  IK Q +      L+D+     K+   +     Q + Q ++L+    +++ K  S  E
Sbjct: 1838 EIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPE 1897

Query: 1205 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKD-------------STQWLE----- 1246
             R     +I+ I  +  + +E L   R+Q   + +D             S +W E     
Sbjct: 1898 PRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKF 1955

Query: 1247 -------------AKEEAEQVLGQARAKLESWKEGPYTVDA--IQKKITETKQL------ 1285
                          +EE   V+ +      S+    Y  +   + + + E +QL      
Sbjct: 1956 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 2015

Query: 1286 -AKD-----------------LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA 1327
             AKD                 L+Q    +D+ +      L+  +  +  K+      ++ 
Sbjct: 2016 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDF 2075

Query: 1328 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 1387
             W  ++K   +R+   + +    ++F  D++ F  WLTEAE          RK ++ E+ 
Sbjct: 2076 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-------QFLRKTQIPENW 2128

Query: 1388 KGVKELMKQW--QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 1445
            +  K    +W  ++LQ  I     V   L+   ++I++      DA +LQ +L ++N +W
Sbjct: 2129 EHAK---YKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ-SSKTDASILQEKLGSLNLRW 2184

Query: 1446 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 1505
             E+ K+  + +  LE   +        L E ++WL+  D+  S     G +    +K   
Sbjct: 2185 QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ 2244

Query: 1506 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 1565
            V +    EL  ++ ++    ET    L   P+              PEE+ +     L  
Sbjct: 2245 V-KLLVEELPLRQGILKQLNETGGPVLVSAPIS-------------PEEQDK-----LEN 2285

Query: 1566 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDL 1625
            + ++ N +W K++    + Q +I+  ++ L +L++  ++L+ +L    +     +   ++
Sbjct: 2286 KLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEI 2345

Query: 1626 LIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKL 1685
                 Q+    V+     +   + +V  +    + L        P     LEDL++ WK 
Sbjct: 2346 YNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK-RKLEDLSSEWK- 2403

Query: 1686 LQVAVEDRVRQLHEAHRDFGP------ASQHFLSTSVQGP---WERAISPNKVPYYINHE 1736
               AV   +++L     D  P      AS     T V  P    E AIS  ++P  +  E
Sbjct: 2404 ---AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 2460

Query: 1737 TQTTCWDHPKMTELYQSLADLNNV 1760
                   +   TEL   L+ L+ V
Sbjct: 2461 VPALADFNRAWTELTDWLSLLDQV 2484



 Score =  157 bits (396), Expect = 2e-37
 Identities = 333/1864 (17%), Positives = 730/1864 (39%), Gaps = 289/1864 (15%)

Query: 15   LNAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 74
            L  +R Q+ +       Q++E  L + Q S+T  D ++      ++ A Q   + Q  QS
Sbjct: 931  LPPMRYQETMSAIRTWVQQSETKLSIPQLSVT--DYEIMEQRLGELQALQSSLQEQ--QS 986

Query: 75   DLTSHEISLEEMKKH--NQGKEAAQRVLSQIDVAQKKLQDVSMKF-----RLFQKPANFE 127
             L     +++EM K   ++     Q    +I+   KKL    ++          K    +
Sbjct: 987  GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQ 1046

Query: 128  QRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQ 187
              +Q  K  + EV + L        + E+++ QL  C  L   +  ++  +  V + G++
Sbjct: 1047 NHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQK 1106

Query: 188  IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 247
            I  + + E    L+  +  L   ++ +  +V  RK+ L+  L+ +  ++K+++ + EW+ 
Sbjct: 1107 IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMT 1166

Query: 248  ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE------------VGE 295
              + E  +R      P  L   V   K  ++E ++++  +K +TE              E
Sbjct: 1167 QAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQE 1226

Query: 296  ALKTVLGKKE-------TLVEDKLSLLNSNW------IAVTSRAEEWLNLLLEYQKHMET 342
            ALK  L           T +  K   L   W      ++   +A +WLN +    K  E 
Sbjct: 1227 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTEN 1286

Query: 343  FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLK--AELNDIRPKVDSTRDQAANL 400
                 + I++ +   + L+  SE   P Q   + + L     ++++  +   T +     
Sbjct: 1287 IPGGAEEISEVLDSLENLMRHSE-DNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1345

Query: 401  MANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSD-IQKLLEPLEAE 459
            +       +KL+E  I        ++ H I+     I  K+L  + +D +     P EA+
Sbjct: 1346 LHEEAVRRQKLLEQSIQSAQETEKSL-HLIQESLTFID-KQLAAYIADKVDAAQMPQEAQ 1403

Query: 460  IQQGVNLKEEDFNKDMNEDNEGTVK----------------------ELLQRGDNLQQRI 497
              Q      E   ++M + N+G                          L Q+  N +QR+
Sbjct: 1404 KIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRL 1463

Query: 498  TDERK-REEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKC-LDDI 555
             + +   +E+K+    L+TK    + ++SQ     + +     + K + + ++K     +
Sbjct: 1464 QESKMILDEVKMHLPALETKSVEQEVVQSQ-LNHCVNLYKSLSEVKSEVEMVIKTGRQIV 1522

Query: 556  EKKLASLPEPRDER-------------KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAM 602
            +KK    P+  DER             K+ E  ++L+K  +    +R++   L+E  AA 
Sbjct: 1523 QKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAAT 1582

Query: 603  AVE----------PTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTE------ 646
             +E          P+ +     W +   K  + ++++   I  V E    V+ +      
Sbjct: 1583 DMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVE 1642

Query: 647  ---------------------DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 685
                                 ++ LE      T+   + H+++ +++ + LL+  +    
Sbjct: 1643 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1702

Query: 686  DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 745
                  ++E+ LK +K  L     ++D    +    + +     R  ++  +S+L+ ++ 
Sbjct: 1703 Q-----QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFA 1757

Query: 746  KVNKMYKDRQGRFDRSVEKWRRFHYDI-KIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL 804
             ++  ++ + G+    +++  +F+ DI K+      E +Q +          + K + + 
Sbjct: 1758 AIS--HRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGV----------NLKEEDFN 1805

Query: 805  KEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKK 863
            K++ +D  G  + +++  +   + I  +  + +  I Q+ L + +   +++    S R+K
Sbjct: 1806 KDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL---RSQRRK 1862

Query: 864  RLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLR 922
            +  E  +   +++R  ++ +  L++ +  +AS+P EP  E+++KE   +++   EEL   
Sbjct: 1863 KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP-EPRDERKIKEIDRELQKKKEELNAV 1921

Query: 923  QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 982
            +   + L+E G  + V            E    Q + +W ++     + +    AQI  +
Sbjct: 1922 RRQAEGLSEDGAAMAV------------EPTQIQLSKRWREIESKFAQFRRLNFAQIHTV 1969

Query: 983  GQ--LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEE 1040
             +  +    ED+  +++++     P     EI +    +   +V++   A      D E+
Sbjct: 1970 REETMMVMTEDMPLEISYV-----PSTYLTEITHV--SQALLEVEQLLNAPDLCAKDFED 2022

Query: 1041 ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQT 1100
            +  + + L   K + Q    +++ + S+  A  +                    A+P + 
Sbjct: 2023 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQ-------------------SATPVER 2063

Query: 1101 VTLVTQPVVTKETAISKLEMPSSLMLEV--PALADFNRA---WTE-------LTDWLSLL 1148
            V L        + A+S+L+     + ++       F+R+   W            WL+  
Sbjct: 2064 VKL--------QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEA 2115

Query: 1149 DQVIKSQRVMVGDLEDINEMIIKQKATMQD-LEQRRPQLEELITAAQNLKNKTSNQEART 1207
            +Q ++  ++         +  +K+   +QD + QR+  +  L    + +  ++S  +A +
Sbjct: 2116 EQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDA-S 2171

Query: 1208 IITDRIERIQNQWDEVQEHLQNRRQQ-------LNEMLKDSTQWLEAKEEAEQVLGQARA 1260
            I+ +++  +  +W EV + L +R+++       L+E  +D  +++   EEA+ +   A  
Sbjct: 2172 ILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI---ASI 2228

Query: 1261 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL--RDYSADDTRKV 1318
             LE  KE       +++K+ + K L ++L   Q  +   N+    +L     S ++  K+
Sbjct: 2229 PLEPGKE-----QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2283

Query: 1319 HMITENINASWRSIHKRVSEREAALE-------ETHRLLQQFPLDLEKFLAWL------- 1364
                +  N  W  + + + E++  +E       +  + L+     L   L WL       
Sbjct: 2284 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2343

Query: 1365 ----------------TEAETTA---NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIE 1405
                            TE    A   +V +  ++ + L ++    + + ++ +DL  E +
Sbjct: 2344 EIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWK 2403

Query: 1406 AHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQ 1465
            A   +   L      +   L     +      L        E     L + S L      
Sbjct: 2404 AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA 2463

Query: 1466 WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTL 1525
                + +  EL  WL L D  +  Q  + GD   + +     +A  ++L+ + P      
Sbjct: 2464 LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP------ 2517

Query: 1526 ETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQ 1585
                          LE+L    + L  +   Q    ++  + E +  +W+++  H  + +
Sbjct: 2518 -------------QLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRR 2564

Query: 1586 RKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIA 1645
            ++++E L+   +  EA +E +  L QA     SW+  G   +D++Q  + + K L  ++ 
Sbjct: 2565 QQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE-GPYTVDAIQKKITETKQLAKDLR 2623

Query: 1646 PLKENVSHVNDLARQLTTLGIQLSPYNLS-------TLEDLNTRWKLLQVAVEDRVRQLH 1698
              + NV   NDLA +L      L  Y+           E++N  W+ +   V +R   L 
Sbjct: 2624 QWQTNVDVANDLALKL------LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2677

Query: 1699 EAHR 1702
            E HR
Sbjct: 2678 ETHR 2681



 Score =  107 bits (266), Expect = 2e-22
 Identities = 244/1327 (18%), Positives = 522/1327 (39%), Gaps = 212/1327 (15%)

Query: 304  KETLVEDKLSLLNSNWIAV-TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 362
            +ET V+++++LLNS W  +  +  E+  NL   ++  M+  +Q +  +  W+ + +    
Sbjct: 408  EETEVQEQMNLLNSRWECLRVASMEKQSNL---HRVLMDLQNQKLKELNDWLTKTEERTR 464

Query: 363  ESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 415
            + E++      + LKR       L+ +L   + +V+S       +  + GDH    +E Q
Sbjct: 465  KMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ 524

Query: 416  ISELNHRFAAISHRIKTGKASIPLKELE---QFNSDIQKLLEPLEAEIQQGVNLKEEDFN 472
            +  L  R+A I     T    + L+++    Q  ++ Q L     +E +  VN       
Sbjct: 525  LKVLGDRWANICRW--TEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 582

Query: 473  KDMNEDNEGTVKELLQRGDNLQQRITDERKREEI----KIKQQLLQTKHNALKDLRSQRR 528
            KD NE      K  + + D        E+K++ +     +KQ LL T  N          
Sbjct: 583  KDQNEMLSSLQKLAVLKADL-------EKKKQSMGKLYSLKQDLLSTLKN---------- 625

Query: 529  KKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 588
            K   + +  W       D+  +C D++ +KL        E+   +I + +   +  L   
Sbjct: 626  KSVTQKTEAWL------DNFARCWDNLVQKL--------EKSTAQISQAVTTTQPSLTQT 671

Query: 589  RRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDM 648
                     +         QI +     E+     Q +R    QI TV  E    +  D 
Sbjct: 672  TVM------ETVTTVTTREQILVKHAQEELPPPPPQKKR----QI-TVDSEIRKRLDVD- 719

Query: 649  PLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSS 708
                          IT +   +   E +L +P+        +F++E +  ++K+ +    
Sbjct: 720  --------------ITELHSWITRSEAVLQSPEFA------IFRKEGNFSDLKEKVNA-- 757

Query: 709  GRIDIIHSKKTAALQSATP-------------VERVKLQEALSQLDFQWEKVNKMYKDRQ 755
              I+   ++K   LQ A+              V    +++A  QL+ +W +  ++  +R 
Sbjct: 758  --IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERL 815

Query: 756  GRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW---------EHAKYKWYLKE 806
                     W  +  +I  F   L + EQ    T   ENW         E    K  LK 
Sbjct: 816  N--------WLEYQNNIIAFYNQLQQLEQM---TTTAENWLKIQPTTPSEPTAIKSQLKI 864

Query: 807  LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASI-LQEKLGSLNLRWQEVCKQLSDRKKRL 865
             +D + +   +   +     + I    K    + L     +    +++V   +  R+K L
Sbjct: 865  CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKEL 924

Query: 866  EEQKNILS--EFQRDLNEFVLWLEEADNIASIP-LEPGKEQQLKEKLEQVKLLVEELPLR 922
            +   + L    +Q  ++    W+++++   SIP L     + ++++L +++ L   L  +
Sbjct: 925  QTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQ 984

Query: 923  QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 982
            Q  L  L+ T   +   AP   E   K +++ ++   +W K+S  L E   ++E Q+  L
Sbjct: 985  QSGLYYLSTTVKEMSKKAP--SEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKL 1042

Query: 983  GQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 1039
             +++  ++ L++ +  + ++L    P     EI  +  ++    V +    +Q  QP + 
Sbjct: 1043 RKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD----IQTIQPSLN 1098

Query: 1040 EILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 1097
             +   GQ +  E        ++ +L++L+++W   + + Q++ A++  L  GL       
Sbjct: 1099 SVNEGGQKIKNEAEPEFASRLETELKELNTQW---DHMCQQVYARKEALKGGLE------ 1149

Query: 1098 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 1157
             +TV+L                                +  +E+ +W++  ++    +  
Sbjct: 1150 -KTVSL-------------------------------QKDLSEMHEWMTQAEEEYLERDF 1177

Query: 1158 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 1217
                 +++ + + + K   ++ +Q+  +++ L+T + N     +   A+  +   +E + 
Sbjct: 1178 EYKTPDELQKAVEEMKRAKEEAQQKEAKVK-LLTESVNSVIAQAPPVAQEALKKELETLT 1236

Query: 1218 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 1277
              +  +   L  + + L E+     + L   E+A + L +   KL++ +  P   + I +
Sbjct: 1237 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1296

Query: 1278 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 1337
             +   + L   +R  + N +    LA  L      D+   ++   E  N+ WR +H+   
Sbjct: 1297 VLDSLENL---MRHSEDNPNQIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAV 1351

Query: 1338 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1397
             R+  LE++ +  Q    + EK L  + E+ T  +      +    + D     ++ ++ 
Sbjct: 1352 RRQKLLEQSIQSAQ----ETEKSLHLIQESLTFID-----KQLAAYIADKVDAAQMPQEA 1402

Query: 1398 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1457
            Q +Q ++ +H      + +++Q    +        + Q++L +++ K+  L +K  N   
Sbjct: 1403 QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQ 1461

Query: 1458 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1517
             L+ S        + L E+ + L   + +   Q  +      +    +++++        
Sbjct: 1462 RLQESK-------MILDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEVKSEV 1511

Query: 1518 EPVIMSTLETVRIFLTEQPLEGLE-----KLYQEPRELPPEERAQNVTRLL---RKQAEE 1569
            E VI +  + V+   TE P E  E     KL+         ER Q + + L   RK  +E
Sbjct: 1512 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1571

Query: 1570 VN--TEW 1574
            +N  TEW
Sbjct: 1572 MNVLTEW 1578



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 190/965 (19%), Positives = 382/965 (39%), Gaps = 98/965 (10%)

Query: 778  WLTEAEQFLR-KTQIPENWEHAKYKWYLKE--LQDGIGQRQTVVRTLNATGEEIIQQS-- 832
            WL  AE  L+ + +I  + E  K +++  E  + D +   Q  V  +   G ++I     
Sbjct: 346  WLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD-LTAHQGRVGNILQLGSKLIGTGKL 404

Query: 833  SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWL----EE 888
            S+ + + +QE++  LN RW+  C +++  +K+    + ++    + L E   WL    E 
Sbjct: 405  SEDEETEVQEQMNLLNSRWE--CLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEER 462

Query: 889  ADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD 948
               +   PL P  E  LK +++Q K+L E+L   Q  +  L  T   V+V          
Sbjct: 463  TRKMEEEPLGPDLED-LKRQVQQHKVLQEDLEQEQVRVNSL--THMVVVVDESSGDHATA 519

Query: 949  KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 1008
             LE +LK    +W  + R   ++   ++        +  K + L E+      WLS    
Sbjct: 520  ALEEQLKVLGDRWANICRWTEDRWVLLQ-------DILLKWQRLTEEQCLFSAWLS---E 569

Query: 1009 QLEIYNQPNQEGPFDVQETEIAVQA----------KQPDVEEILSKGQHLY---KEKPAT 1055
            + +  N+ +  G  D  E   ++Q           K+  + ++ S  Q L    K K  T
Sbjct: 570  KEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT 629

Query: 1056 QPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI 1115
            Q  +  L++ +  W   + L+Q+L      ++  +TT   S TQT  + T   VT    I
Sbjct: 630  QKTEAWLDNFARCW---DNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQI 686

Query: 1116 ----SKLEMPS-------SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMV----G 1160
                ++ E+P         + ++       +   TEL  W++  + V++S    +    G
Sbjct: 687  LVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEG 746

Query: 1161 DLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART-IITDRIERIQNQ 1219
            +  D+ E   K  A  ++  ++  +L++   +AQ L  +  N+      I    E++ ++
Sbjct: 747  NFSDLKE---KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 803

Query: 1220 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 1279
            W E  + L  R   L E   +   +    ++ EQ+   A   L+     P    AI+ ++
Sbjct: 804  WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 862

Query: 1280 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 1339
               K     L   Q  ++     ++ L              +       ++ +   V  R
Sbjct: 863  KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA--FTNHFKQVFSDVQAR 920

Query: 1340 EAALEETHRLL--QQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1397
            E  L+     L   ++   +     W+ ++ET  ++ Q +     ++E   G      + 
Sbjct: 921  EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG------EL 974

Query: 1398 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1457
            Q LQ  ++      + L    +++ +    S+ +   Q   + +  +W +L  + +    
Sbjct: 975  QALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1033

Query: 1458 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1517
             LE   ++ +++   +Q L  W+   D  L  + P  GD   ++KQ    R    +++T 
Sbjct: 1034 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 1093

Query: 1518 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 1577
            +P + S              EG +K+     E  PE  ++     L  + +E+NT+W+ +
Sbjct: 1094 QPSLNSV------------NEGGQKI---KNEAEPEFASR-----LETELKELNTQWDHM 1133

Query: 1578 NLHSADWQRKIDETLERLQELQEATDELDLKLRQA--EVIKGSWQPVGDLLIDSLQDHLE 1635
                   +  +   LE+   LQ+   E+   + QA  E ++  ++       D LQ  +E
Sbjct: 1134 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP---DELQKAVE 1190

Query: 1636 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRV 1694
            ++K  + E    +  V  + +    +      ++   L   LE L T ++ L   +  + 
Sbjct: 1191 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1250

Query: 1695 RQLHE 1699
            + L E
Sbjct: 1251 KTLEE 1255



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 76/369 (20%), Positives = 140/369 (37%), Gaps = 28/369 (7%)

Query: 1098 TQTVTLVTQPVVTKETAISKLEMP------SSLMLEVPALADFNRAWTELTDWLSLLDQV 1151
            TQ   + T            LE P      SSLM     L  +  A  E+  WL   +  
Sbjct: 294  TQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDT 353

Query: 1152 IKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNL--------KNKTSNQ 1203
            +++Q  +  D+E + +     +  M DL   + ++  ++     L          +T  Q
Sbjct: 354  LQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQ 413

Query: 1204 EARTIITDRIERIQNQWDEVQEHLQNRRQQL-NEMLKDSTQWLEAKEEAEQVLGQARAKL 1262
            E   ++  R E ++    E Q +L      L N+ LK+   WL   EE  +       K+
Sbjct: 414  EQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTR-------KM 466

Query: 1263 ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMIT 1322
            E    GP  ++ +++++ + K L +DL Q Q  V+    + + +        T  +    
Sbjct: 467  EEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQL 525

Query: 1323 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1382
            + +   W +I +   +R   L++     Q+   +   F AWL+E E   N +     K  
Sbjct: 526  KVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFK-- 583

Query: 1383 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1442
               D   +   +++   L+ ++E        L    Q +L +L+        +  LDN  
Sbjct: 584  ---DQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 640

Query: 1443 FKWSELRKK 1451
              W  L +K
Sbjct: 641  RCWDNLVQK 649



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)

Query: 1405 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 1459
            E H  ++H +  + Q  +   +G +     + R  +  +  +     S   RS     HL
Sbjct: 255  EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 314

Query: 1460 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 1507
            EA  D+              R   +L+E+L WL   +D L  Q  I  D   V+ Q   H
Sbjct: 315  EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 374

Query: 1508 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 1567
              +  +L   +  + + L+          L G  KL ++      EE        +++Q 
Sbjct: 375  EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 416

Query: 1568 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 1622
              +N+ WE L + S + Q  +   L     ++L+EL +   + + + R+ E      +P+
Sbjct: 417  NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 471

Query: 1623 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 1678
            G  L D L+  +++ K L+ +   L++    VN L   +  +      +  + LE+    
Sbjct: 472  GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 527

Query: 1679 LNTRWKLLQVAVEDR 1693
            L  RW  +    EDR
Sbjct: 528  LGDRWANICRWTEDR 542


>gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]
          Length = 3562

 Score = 4597 bits (11923), Expect = 0.0
 Identities = 2328/2328 (100%), Positives = 2328/2328 (100%)

Query: 17   AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL 76
            AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL
Sbjct: 1235 AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL 1294

Query: 77   TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 136
            TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI
Sbjct: 1295 TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1354

Query: 137  LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 196
            LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN
Sbjct: 1355 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1414

Query: 197  PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 256
            PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR
Sbjct: 1415 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1474

Query: 257  SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN 316
            SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN
Sbjct: 1475 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN 1534

Query: 317  SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL 376
            SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL
Sbjct: 1535 SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL 1594

Query: 377  KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS 436
            KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS
Sbjct: 1595 KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS 1654

Query: 437  IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 496
            IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR
Sbjct: 1655 IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1714

Query: 497  ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 556
            ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE
Sbjct: 1715 ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 1774

Query: 557  KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR 616
            KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR
Sbjct: 1775 KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR 1834

Query: 617  EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 676
            EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL
Sbjct: 1835 EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 1894

Query: 677  LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 736
            LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA
Sbjct: 1895 LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 1954

Query: 737  LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE 796
            LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE
Sbjct: 1955 LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE 2014

Query: 797  HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK 856
            HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK
Sbjct: 2015 HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK 2074

Query: 857  QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV 916
            QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV
Sbjct: 2075 QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV 2134

Query: 917  EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE 976
            EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE
Sbjct: 2135 EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE 2194

Query: 977  AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 1036
            AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP
Sbjct: 2195 AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 2254

Query: 1037 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 1096
            DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS
Sbjct: 2255 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 2314

Query: 1097 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 1156
            PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR
Sbjct: 2315 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 2374

Query: 1157 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 1216
            VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI
Sbjct: 2375 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 2434

Query: 1217 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 1276
            QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ
Sbjct: 2435 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 2494

Query: 1277 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV 1336
            KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV
Sbjct: 2495 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV 2554

Query: 1337 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 1396
            SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ
Sbjct: 2555 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 2614

Query: 1397 WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR 1456
            WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR
Sbjct: 2615 WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR 2674

Query: 1457 SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 1516
            SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT
Sbjct: 2675 SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 2734

Query: 1517 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 1576
            KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK
Sbjct: 2735 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 2794

Query: 1577 LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK 1636
            LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK
Sbjct: 2795 LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK 2854

Query: 1637 VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 1696
            VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ
Sbjct: 2855 VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 2914

Query: 1697 LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD 1756
            LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD
Sbjct: 2915 LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD 2974

Query: 1757 LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI 1816
            LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI
Sbjct: 2975 LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI 3034

Query: 1817 YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY 1876
            YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY
Sbjct: 3035 YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY 3094

Query: 1877 LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE 1936
            LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE
Sbjct: 3095 LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE 3154

Query: 1937 AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC 1996
            AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC
Sbjct: 3155 AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC 3214

Query: 1997 QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV 2056
            QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV
Sbjct: 3215 QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV 3274

Query: 2057 QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND 2116
            QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND
Sbjct: 3275 QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND 3334

Query: 2117 SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN 2176
            SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN
Sbjct: 3335 SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN 3394

Query: 2177 RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 2236
            RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ
Sbjct: 3395 RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 3454

Query: 2237 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 2296
            ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS
Sbjct: 3455 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 3514

Query: 2297 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2344
            DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 3515 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 3562



 Score =  186 bits (473), Expect = 2e-46
 Identities = 339/1824 (18%), Positives = 721/1824 (39%), Gaps = 209/1824 (11%)

Query: 56   IADKVDAAQMP--QEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL-QD 112
            + +KV+A +    ++ +K+Q    S +  +E+M       ++ ++   Q++    +  Q 
Sbjct: 636  LKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQL 695

Query: 113  VSMKFRLFQKPAN---FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 169
            +S +    +   N   F  +LQ+ + +    +  L    T   E   ++SQL  C +   
Sbjct: 696  LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 755

Query: 170  SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 229
             LS ++ ++E +    + I  K++ + P  LD    A   H+ ++ + V  R+++L+   
Sbjct: 756  RLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIF 813

Query: 230  KLSRKMR--KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 287
                 MR  + M+ +  W+  ++ +L+           ++  +   +A Q  +++Q+  L
Sbjct: 814  DTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGL 873

Query: 288  KSI-TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 346
              + T V E  K    +     + +   +   W  ++S+  E    L E    +     +
Sbjct: 874  YYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 933

Query: 347  VDHITKWIIQADTLLDE-------SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 399
            +  + KW+ + D  L E       SE  K Q K+   + L +++  I+P ++S  +    
Sbjct: 934  IQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQ--CRLLVSDIQTIQPSLNSVNEGGQK 991

Query: 400  LMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE 459
            +           +E ++ ELN ++  +  ++   K ++    LE+  S  + L E  E  
Sbjct: 992  IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALK-GGLEKTVSLQKDLSEMHEWM 1050

Query: 460  IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDER----------------KR 503
             Q      E DF     ++ +  V+E+ +  +  QQ+    +                 +
Sbjct: 1051 TQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1110

Query: 504  EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 563
            E +K + + L T +  L    + + K   E+   W++     +   K L+++E KL +  
Sbjct: 1111 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTE 1170

Query: 564  E-PRDERKIKEI----DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-LSKRWRE 617
              P    +I E+    +  ++  ++  N +R  A+ L++ G    +   +++  + RWRE
Sbjct: 1171 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1230

Query: 618  IESKFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 676
            +  +  + ++L    I + +E E  + + ++    I    + Y+ +    +Q   E +++
Sbjct: 1231 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI 1290

Query: 677  LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 736
             +          DL   E SL+ +K   Q           K+ A             Q  
Sbjct: 1291 QS----------DLTSHEISLEEMKKHNQ----------GKEAA-------------QRV 1317

Query: 737  LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL--RKTQIPEN 794
            LSQ+D   +K+    +D   +F R  +K   F   ++     L E +  L   +T+  E 
Sbjct: 1318 LSQIDVAQKKL----QDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1372

Query: 795  WEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 854
                    +   L   + + ++ V  +  TG +I+Q+    +   L E++ +L L + E+
Sbjct: 1373 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1432

Query: 855  CKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVK 913
              ++++RK++LE+   +  + ++++N    WL   D  +       G    L  ++   K
Sbjct: 1433 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGK 1492

Query: 914  LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 973
               +E+  ++  LK + E G  +     +  +++  +E+KL   N  WI V+        
Sbjct: 1493 ATQKEIEKQKVHLKSITEVGEAL---KTVLGKKETLVEDKLSLLNSNWIAVT-------S 1542

Query: 974  EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV-QETEIAVQ 1032
              E  +  L + +K +E  ++ ++H+  W+      L+   +   +   DV +  +  + 
Sbjct: 1543 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELN 1602

Query: 1033 AKQPDVEEILSKGQHLYKEK--PATQPVKRKLEDLSSEWKAVNRLLQELRAKQP--DLAP 1088
              +P V+    +  +L   +     + V+ ++ +L+  + A++  ++  +A  P  +L  
Sbjct: 1603 DIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQ 1662

Query: 1089 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 1148
              + I          + Q V  KE   +K     +       L   +     +TD     
Sbjct: 1663 FNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKRE 1722

Query: 1149 DQVIKSQRVMV--GDLEDINEMIIKQKATM-QDLEQRRPQLEELITAAQNLKNK-TSNQE 1204
            +  IK Q +      L+D+     K+   +     Q + Q ++L+    +++ K  S  E
Sbjct: 1723 EIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPE 1782

Query: 1205 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKD-------------STQWLE----- 1246
             R     +I+ I  +  + +E L   R+Q   + +D             S +W E     
Sbjct: 1783 PRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKF 1840

Query: 1247 -------------AKEEAEQVLGQARAKLESWKEGPYTVDA--IQKKITETKQL------ 1285
                          +EE   V+ +      S+    Y  +   + + + E +QL      
Sbjct: 1841 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 1900

Query: 1286 -AKD-----------------LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA 1327
             AKD                 L+Q    +D+ +      L+  +  +  K+      ++ 
Sbjct: 1901 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDF 1960

Query: 1328 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 1387
             W  ++K   +R+   + +    ++F  D++ F  WLTEAE          RK ++ E+ 
Sbjct: 1961 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-------QFLRKTQIPENW 2013

Query: 1388 KGVKELMKQW--QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 1445
            +  K    +W  ++LQ  I     V   L+   ++I++      DA +LQ +L ++N +W
Sbjct: 2014 EHAK---YKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ-SSKTDASILQEKLGSLNLRW 2069

Query: 1446 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 1505
             E+ K+  + +  LE   +        L E ++WL+  D+  S     G +    +K   
Sbjct: 2070 QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ 2129

Query: 1506 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 1565
            V +    EL  ++ ++    ET    L   P+              PEE+ +     L  
Sbjct: 2130 V-KLLVEELPLRQGILKQLNETGGPVLVSAPIS-------------PEEQDK-----LEN 2170

Query: 1566 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDL 1625
            + ++ N +W K++    + Q +I+  ++ L +L++  ++L+ +L    +     +   ++
Sbjct: 2171 KLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEI 2230

Query: 1626 LIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKL 1685
                 Q+    V+     +   + +V  +    + L        P     LEDL++ WK 
Sbjct: 2231 YNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK-RKLEDLSSEWK- 2288

Query: 1686 LQVAVEDRVRQLHEAHRDFGP------ASQHFLSTSVQGP---WERAISPNKVPYYINHE 1736
               AV   +++L     D  P      AS     T V  P    E AIS  ++P  +  E
Sbjct: 2289 ---AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 2345

Query: 1737 TQTTCWDHPKMTELYQSLADLNNV 1760
                   +   TEL   L+ L+ V
Sbjct: 2346 VPALADFNRAWTELTDWLSLLDQV 2369



 Score =  157 bits (396), Expect = 2e-37
 Identities = 333/1864 (17%), Positives = 730/1864 (39%), Gaps = 289/1864 (15%)

Query: 15   LNAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 74
            L  +R Q+ +       Q++E  L + Q S+T  D ++      ++ A Q   + Q  QS
Sbjct: 816  LPPMRYQETMSAIRTWVQQSETKLSIPQLSVT--DYEIMEQRLGELQALQSSLQEQ--QS 871

Query: 75   DLTSHEISLEEMKKH--NQGKEAAQRVLSQIDVAQKKLQDVSMKF-----RLFQKPANFE 127
             L     +++EM K   ++     Q    +I+   KKL    ++          K    +
Sbjct: 872  GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQ 931

Query: 128  QRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQ 187
              +Q  K  + EV + L        + E+++ QL  C  L   +  ++  +  V + G++
Sbjct: 932  NHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQK 991

Query: 188  IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 247
            I  + + E    L+  +  L   ++ +  +V  RK+ L+  L+ +  ++K+++ + EW+ 
Sbjct: 992  IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMT 1051

Query: 248  ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE------------VGE 295
              + E  +R      P  L   V   K  ++E ++++  +K +TE              E
Sbjct: 1052 QAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQE 1111

Query: 296  ALKTVLGKKE-------TLVEDKLSLLNSNW------IAVTSRAEEWLNLLLEYQKHMET 342
            ALK  L           T +  K   L   W      ++   +A +WLN +    K  E 
Sbjct: 1112 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTEN 1171

Query: 343  FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLK--AELNDIRPKVDSTRDQAANL 400
                 + I++ +   + L+  SE   P Q   + + L     ++++  +   T +     
Sbjct: 1172 IPGGAEEISEVLDSLENLMRHSE-DNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1230

Query: 401  MANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSD-IQKLLEPLEAE 459
            +       +KL+E  I        ++ H I+     I  K+L  + +D +     P EA+
Sbjct: 1231 LHEEAVRRQKLLEQSIQSAQETEKSL-HLIQESLTFID-KQLAAYIADKVDAAQMPQEAQ 1288

Query: 460  IQQGVNLKEEDFNKDMNEDNEGTVK----------------------ELLQRGDNLQQRI 497
              Q      E   ++M + N+G                          L Q+  N +QR+
Sbjct: 1289 KIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRL 1348

Query: 498  TDERK-REEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKC-LDDI 555
             + +   +E+K+    L+TK    + ++SQ     + +     + K + + ++K     +
Sbjct: 1349 QESKMILDEVKMHLPALETKSVEQEVVQSQ-LNHCVNLYKSLSEVKSEVEMVIKTGRQIV 1407

Query: 556  EKKLASLPEPRDER-------------KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAM 602
            +KK    P+  DER             K+ E  ++L+K  +    +R++   L+E  AA 
Sbjct: 1408 QKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAAT 1467

Query: 603  AVE----------PTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTE------ 646
             +E          P+ +     W +   K  + ++++   I  V E    V+ +      
Sbjct: 1468 DMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVE 1527

Query: 647  ---------------------DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 685
                                 ++ LE      T+   + H+++ +++ + LL+  +    
Sbjct: 1528 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1587

Query: 686  DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 745
                  ++E+ LK +K  L     ++D    +    + +     R  ++  +S+L+ ++ 
Sbjct: 1588 Q-----QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFA 1642

Query: 746  KVNKMYKDRQGRFDRSVEKWRRFHYDI-KIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL 804
             ++  ++ + G+    +++  +F+ DI K+      E +Q +          + K + + 
Sbjct: 1643 AIS--HRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGV----------NLKEEDFN 1690

Query: 805  KEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKK 863
            K++ +D  G  + +++  +   + I  +  + +  I Q+ L + +   +++    S R+K
Sbjct: 1691 KDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL---RSQRRK 1747

Query: 864  RLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLR 922
            +  E  +   +++R  ++ +  L++ +  +AS+P EP  E+++KE   +++   EEL   
Sbjct: 1748 KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP-EPRDERKIKEIDRELQKKKEELNAV 1806

Query: 923  QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 982
            +   + L+E G  + V            E    Q + +W ++     + +    AQI  +
Sbjct: 1807 RRQAEGLSEDGAAMAV------------EPTQIQLSKRWREIESKFAQFRRLNFAQIHTV 1854

Query: 983  GQ--LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEE 1040
             +  +    ED+  +++++     P     EI +    +   +V++   A      D E+
Sbjct: 1855 REETMMVMTEDMPLEISYV-----PSTYLTEITHV--SQALLEVEQLLNAPDLCAKDFED 1907

Query: 1041 ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQT 1100
            +  + + L   K + Q    +++ + S+  A  +                    A+P + 
Sbjct: 1908 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQ-------------------SATPVER 1948

Query: 1101 VTLVTQPVVTKETAISKLEMPSSLMLEV--PALADFNRA---WTE-------LTDWLSLL 1148
            V L        + A+S+L+     + ++       F+R+   W            WL+  
Sbjct: 1949 VKL--------QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEA 2000

Query: 1149 DQVIKSQRVMVGDLEDINEMIIKQKATMQD-LEQRRPQLEELITAAQNLKNKTSNQEART 1207
            +Q ++  ++         +  +K+   +QD + QR+  +  L    + +  ++S  +A +
Sbjct: 2001 EQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDA-S 2056

Query: 1208 IITDRIERIQNQWDEVQEHLQNRRQQ-------LNEMLKDSTQWLEAKEEAEQVLGQARA 1260
            I+ +++  +  +W EV + L +R+++       L+E  +D  +++   EEA+ +   A  
Sbjct: 2057 ILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI---ASI 2113

Query: 1261 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL--RDYSADDTRKV 1318
             LE  KE       +++K+ + K L ++L   Q  +   N+    +L     S ++  K+
Sbjct: 2114 PLEPGKE-----QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2168

Query: 1319 HMITENINASWRSIHKRVSEREAALE-------ETHRLLQQFPLDLEKFLAWL------- 1364
                +  N  W  + + + E++  +E       +  + L+     L   L WL       
Sbjct: 2169 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2228

Query: 1365 ----------------TEAETTA---NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIE 1405
                            TE    A   +V +  ++ + L ++    + + ++ +DL  E +
Sbjct: 2229 EIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWK 2288

Query: 1406 AHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQ 1465
            A   +   L      +   L     +      L        E     L + S L      
Sbjct: 2289 AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA 2348

Query: 1466 WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTL 1525
                + +  EL  WL L D  +  Q  + GD   + +     +A  ++L+ + P      
Sbjct: 2349 LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP------ 2402

Query: 1526 ETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQ 1585
                          LE+L    + L  +   Q    ++  + E +  +W+++  H  + +
Sbjct: 2403 -------------QLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRR 2449

Query: 1586 RKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIA 1645
            ++++E L+   +  EA +E +  L QA     SW+  G   +D++Q  + + K L  ++ 
Sbjct: 2450 QQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE-GPYTVDAIQKKITETKQLAKDLR 2508

Query: 1646 PLKENVSHVNDLARQLTTLGIQLSPYNLS-------TLEDLNTRWKLLQVAVEDRVRQLH 1698
              + NV   NDLA +L      L  Y+           E++N  W+ +   V +R   L 
Sbjct: 2509 QWQTNVDVANDLALKL------LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2562

Query: 1699 EAHR 1702
            E HR
Sbjct: 2563 ETHR 2566



 Score =  107 bits (266), Expect = 2e-22
 Identities = 244/1327 (18%), Positives = 522/1327 (39%), Gaps = 212/1327 (15%)

Query: 304  KETLVEDKLSLLNSNWIAV-TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 362
            +ET V+++++LLNS W  +  +  E+  NL   ++  M+  +Q +  +  W+ + +    
Sbjct: 293  EETEVQEQMNLLNSRWECLRVASMEKQSNL---HRVLMDLQNQKLKELNDWLTKTEERTR 349

Query: 363  ESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 415
            + E++      + LKR       L+ +L   + +V+S       +  + GDH    +E Q
Sbjct: 350  KMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ 409

Query: 416  ISELNHRFAAISHRIKTGKASIPLKELE---QFNSDIQKLLEPLEAEIQQGVNLKEEDFN 472
            +  L  R+A I     T    + L+++    Q  ++ Q L     +E +  VN       
Sbjct: 410  LKVLGDRWANICRW--TEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 467

Query: 473  KDMNEDNEGTVKELLQRGDNLQQRITDERKREEI----KIKQQLLQTKHNALKDLRSQRR 528
            KD NE      K  + + D        E+K++ +     +KQ LL T  N          
Sbjct: 468  KDQNEMLSSLQKLAVLKADL-------EKKKQSMGKLYSLKQDLLSTLKN---------- 510

Query: 529  KKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 588
            K   + +  W       D+  +C D++ +KL        E+   +I + +   +  L   
Sbjct: 511  KSVTQKTEAWL------DNFARCWDNLVQKL--------EKSTAQISQAVTTTQPSLTQT 556

Query: 589  RRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDM 648
                     +         QI +     E+     Q +R    QI TV  E    +  D 
Sbjct: 557  TVM------ETVTTVTTREQILVKHAQEELPPPPPQKKR----QI-TVDSEIRKRLDVD- 604

Query: 649  PLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSS 708
                          IT +   +   E +L +P+        +F++E +  ++K+ +    
Sbjct: 605  --------------ITELHSWITRSEAVLQSPEFA------IFRKEGNFSDLKEKVNA-- 642

Query: 709  GRIDIIHSKKTAALQSATP-------------VERVKLQEALSQLDFQWEKVNKMYKDRQ 755
              I+   ++K   LQ A+              V    +++A  QL+ +W +  ++  +R 
Sbjct: 643  --IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERL 700

Query: 756  GRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW---------EHAKYKWYLKE 806
                     W  +  +I  F   L + EQ    T   ENW         E    K  LK 
Sbjct: 701  N--------WLEYQNNIIAFYNQLQQLEQM---TTTAENWLKIQPTTPSEPTAIKSQLKI 749

Query: 807  LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASI-LQEKLGSLNLRWQEVCKQLSDRKKRL 865
             +D + +   +   +     + I    K    + L     +    +++V   +  R+K L
Sbjct: 750  CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKEL 809

Query: 866  EEQKNILS--EFQRDLNEFVLWLEEADNIASIP-LEPGKEQQLKEKLEQVKLLVEELPLR 922
            +   + L    +Q  ++    W+++++   SIP L     + ++++L +++ L   L  +
Sbjct: 810  QTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQ 869

Query: 923  QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 982
            Q  L  L+ T   +   AP   E   K +++ ++   +W K+S  L E   ++E Q+  L
Sbjct: 870  QSGLYYLSTTVKEMSKKAP--SEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKL 927

Query: 983  GQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 1039
             +++  ++ L++ +  + ++L    P     EI  +  ++    V +    +Q  QP + 
Sbjct: 928  RKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD----IQTIQPSLN 983

Query: 1040 EILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 1097
             +   GQ +  E        ++ +L++L+++W   + + Q++ A++  L  GL       
Sbjct: 984  SVNEGGQKIKNEAEPEFASRLETELKELNTQW---DHMCQQVYARKEALKGGLE------ 1034

Query: 1098 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 1157
             +TV+L                                +  +E+ +W++  ++    +  
Sbjct: 1035 -KTVSL-------------------------------QKDLSEMHEWMTQAEEEYLERDF 1062

Query: 1158 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 1217
                 +++ + + + K   ++ +Q+  +++ L+T + N     +   A+  +   +E + 
Sbjct: 1063 EYKTPDELQKAVEEMKRAKEEAQQKEAKVK-LLTESVNSVIAQAPPVAQEALKKELETLT 1121

Query: 1218 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 1277
              +  +   L  + + L E+     + L   E+A + L +   KL++ +  P   + I +
Sbjct: 1122 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1181

Query: 1278 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 1337
             +   + L   +R  + N +    LA  L      D+   ++   E  N+ WR +H+   
Sbjct: 1182 VLDSLENL---MRHSEDNPNQIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAV 1236

Query: 1338 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1397
             R+  LE++ +  Q    + EK L  + E+ T  +      +    + D     ++ ++ 
Sbjct: 1237 RRQKLLEQSIQSAQ----ETEKSLHLIQESLTFID-----KQLAAYIADKVDAAQMPQEA 1287

Query: 1398 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1457
            Q +Q ++ +H      + +++Q    +        + Q++L +++ K+  L +K  N   
Sbjct: 1288 QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQ 1346

Query: 1458 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1517
             L+ S        + L E+ + L   + +   Q  +      +    +++++        
Sbjct: 1347 RLQESK-------MILDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEVKSEV 1396

Query: 1518 EPVIMSTLETVRIFLTEQPLEGLE-----KLYQEPRELPPEERAQNVTRLL---RKQAEE 1569
            E VI +  + V+   TE P E  E     KL+         ER Q + + L   RK  +E
Sbjct: 1397 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1456

Query: 1570 VN--TEW 1574
            +N  TEW
Sbjct: 1457 MNVLTEW 1463



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 190/965 (19%), Positives = 382/965 (39%), Gaps = 98/965 (10%)

Query: 778  WLTEAEQFLR-KTQIPENWEHAKYKWYLKE--LQDGIGQRQTVVRTLNATGEEIIQQS-- 832
            WL  AE  L+ + +I  + E  K +++  E  + D +   Q  V  +   G ++I     
Sbjct: 231  WLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD-LTAHQGRVGNILQLGSKLIGTGKL 289

Query: 833  SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWL----EE 888
            S+ + + +QE++  LN RW+  C +++  +K+    + ++    + L E   WL    E 
Sbjct: 290  SEDEETEVQEQMNLLNSRWE--CLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEER 347

Query: 889  ADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD 948
               +   PL P  E  LK +++Q K+L E+L   Q  +  L  T   V+V          
Sbjct: 348  TRKMEEEPLGPDLED-LKRQVQQHKVLQEDLEQEQVRVNSL--THMVVVVDESSGDHATA 404

Query: 949  KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 1008
             LE +LK    +W  + R   ++   ++        +  K + L E+      WLS    
Sbjct: 405  ALEEQLKVLGDRWANICRWTEDRWVLLQ-------DILLKWQRLTEEQCLFSAWLS---E 454

Query: 1009 QLEIYNQPNQEGPFDVQETEIAVQA----------KQPDVEEILSKGQHLY---KEKPAT 1055
            + +  N+ +  G  D  E   ++Q           K+  + ++ S  Q L    K K  T
Sbjct: 455  KEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT 514

Query: 1056 QPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI 1115
            Q  +  L++ +  W   + L+Q+L      ++  +TT   S TQT  + T   VT    I
Sbjct: 515  QKTEAWLDNFARCW---DNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQI 571

Query: 1116 ----SKLEMPS-------SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMV----G 1160
                ++ E+P         + ++       +   TEL  W++  + V++S    +    G
Sbjct: 572  LVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEG 631

Query: 1161 DLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART-IITDRIERIQNQ 1219
            +  D+ E   K  A  ++  ++  +L++   +AQ L  +  N+      I    E++ ++
Sbjct: 632  NFSDLKE---KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 688

Query: 1220 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 1279
            W E  + L  R   L E   +   +    ++ EQ+   A   L+     P    AI+ ++
Sbjct: 689  WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 747

Query: 1280 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 1339
               K     L   Q  ++     ++ L              +       ++ +   V  R
Sbjct: 748  KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA--FTNHFKQVFSDVQAR 805

Query: 1340 EAALEETHRLL--QQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1397
            E  L+     L   ++   +     W+ ++ET  ++ Q +     ++E   G      + 
Sbjct: 806  EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG------EL 859

Query: 1398 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1457
            Q LQ  ++      + L    +++ +    S+ +   Q   + +  +W +L  + +    
Sbjct: 860  QALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 918

Query: 1458 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1517
             LE   ++ +++   +Q L  W+   D  L  + P  GD   ++KQ    R    +++T 
Sbjct: 919  KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 978

Query: 1518 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 1577
            +P + S              EG +K+     E  PE  ++     L  + +E+NT+W+ +
Sbjct: 979  QPSLNSV------------NEGGQKI---KNEAEPEFASR-----LETELKELNTQWDHM 1018

Query: 1578 NLHSADWQRKIDETLERLQELQEATDELDLKLRQA--EVIKGSWQPVGDLLIDSLQDHLE 1635
                   +  +   LE+   LQ+   E+   + QA  E ++  ++       D LQ  +E
Sbjct: 1019 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP---DELQKAVE 1075

Query: 1636 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRV 1694
            ++K  + E    +  V  + +    +      ++   L   LE L T ++ L   +  + 
Sbjct: 1076 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1135

Query: 1695 RQLHE 1699
            + L E
Sbjct: 1136 KTLEE 1140



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 76/369 (20%), Positives = 140/369 (37%), Gaps = 28/369 (7%)

Query: 1098 TQTVTLVTQPVVTKETAISKLEMP------SSLMLEVPALADFNRAWTELTDWLSLLDQV 1151
            TQ   + T            LE P      SSLM     L  +  A  E+  WL   +  
Sbjct: 179  TQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDT 238

Query: 1152 IKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNL--------KNKTSNQ 1203
            +++Q  +  D+E + +     +  M DL   + ++  ++     L          +T  Q
Sbjct: 239  LQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQ 298

Query: 1204 EARTIITDRIERIQNQWDEVQEHLQNRRQQL-NEMLKDSTQWLEAKEEAEQVLGQARAKL 1262
            E   ++  R E ++    E Q +L      L N+ LK+   WL   EE  +       K+
Sbjct: 299  EQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTR-------KM 351

Query: 1263 ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMIT 1322
            E    GP  ++ +++++ + K L +DL Q Q  V+    + + +        T  +    
Sbjct: 352  EEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQL 410

Query: 1323 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1382
            + +   W +I +   +R   L++     Q+   +   F AWL+E E   N +     K  
Sbjct: 411  KVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFK-- 468

Query: 1383 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1442
               D   +   +++   L+ ++E        L    Q +L +L+        +  LDN  
Sbjct: 469  ---DQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 525

Query: 1443 FKWSELRKK 1451
              W  L +K
Sbjct: 526  RCWDNLVQK 534



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)

Query: 1405 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 1459
            E H  ++H +  + Q  +   +G +     + R  +  +  +     S   RS     HL
Sbjct: 140  EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 199

Query: 1460 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 1507
            EA  D+              R   +L+E+L WL   +D L  Q  I  D   V+ Q   H
Sbjct: 200  EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 259

Query: 1508 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 1567
              +  +L   +  + + L+          L G  KL ++      EE        +++Q 
Sbjct: 260  EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 301

Query: 1568 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 1622
              +N+ WE L + S + Q  +   L     ++L+EL +   + + + R+ E      +P+
Sbjct: 302  NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 356

Query: 1623 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 1678
            G  L D L+  +++ K L+ +   L++    VN L   +  +      +  + LE+    
Sbjct: 357  GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 412

Query: 1679 LNTRWKLLQVAVEDR 1693
            L  RW  +    EDR
Sbjct: 413  LGDRWANICRWTEDR 427


>gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]
          Length = 3681

 Score = 4597 bits (11923), Expect = 0.0
 Identities = 2328/2328 (100%), Positives = 2328/2328 (100%)

Query: 17   AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL 76
            AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL
Sbjct: 1354 AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL 1413

Query: 77   TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 136
            TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI
Sbjct: 1414 TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1473

Query: 137  LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 196
            LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN
Sbjct: 1474 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1533

Query: 197  PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 256
            PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR
Sbjct: 1534 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1593

Query: 257  SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN 316
            SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN
Sbjct: 1594 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN 1653

Query: 317  SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL 376
            SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL
Sbjct: 1654 SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL 1713

Query: 377  KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS 436
            KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS
Sbjct: 1714 KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS 1773

Query: 437  IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 496
            IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR
Sbjct: 1774 IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1833

Query: 497  ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 556
            ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE
Sbjct: 1834 ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 1893

Query: 557  KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR 616
            KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR
Sbjct: 1894 KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR 1953

Query: 617  EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 676
            EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL
Sbjct: 1954 EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 2013

Query: 677  LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 736
            LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA
Sbjct: 2014 LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 2073

Query: 737  LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE 796
            LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE
Sbjct: 2074 LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE 2133

Query: 797  HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK 856
            HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK
Sbjct: 2134 HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK 2193

Query: 857  QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV 916
            QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV
Sbjct: 2194 QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV 2253

Query: 917  EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE 976
            EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE
Sbjct: 2254 EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE 2313

Query: 977  AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 1036
            AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP
Sbjct: 2314 AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 2373

Query: 1037 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 1096
            DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS
Sbjct: 2374 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 2433

Query: 1097 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 1156
            PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR
Sbjct: 2434 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 2493

Query: 1157 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 1216
            VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI
Sbjct: 2494 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 2553

Query: 1217 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 1276
            QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ
Sbjct: 2554 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 2613

Query: 1277 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV 1336
            KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV
Sbjct: 2614 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV 2673

Query: 1337 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 1396
            SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ
Sbjct: 2674 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 2733

Query: 1397 WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR 1456
            WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR
Sbjct: 2734 WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR 2793

Query: 1457 SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 1516
            SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT
Sbjct: 2794 SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 2853

Query: 1517 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 1576
            KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK
Sbjct: 2854 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 2913

Query: 1577 LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK 1636
            LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK
Sbjct: 2914 LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK 2973

Query: 1637 VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 1696
            VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ
Sbjct: 2974 VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 3033

Query: 1697 LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD 1756
            LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD
Sbjct: 3034 LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD 3093

Query: 1757 LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI 1816
            LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI
Sbjct: 3094 LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI 3153

Query: 1817 YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY 1876
            YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY
Sbjct: 3154 YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY 3213

Query: 1877 LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE 1936
            LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE
Sbjct: 3214 LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE 3273

Query: 1937 AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC 1996
            AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC
Sbjct: 3274 AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC 3333

Query: 1997 QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV 2056
            QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV
Sbjct: 3334 QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV 3393

Query: 2057 QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND 2116
            QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND
Sbjct: 3394 QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND 3453

Query: 2117 SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN 2176
            SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN
Sbjct: 3454 SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN 3513

Query: 2177 RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 2236
            RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ
Sbjct: 3514 RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 3573

Query: 2237 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 2296
            ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS
Sbjct: 3574 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 3633

Query: 2297 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2344
            DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 3634 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 3681



 Score =  186 bits (473), Expect = 2e-46
 Identities = 339/1824 (18%), Positives = 721/1824 (39%), Gaps = 209/1824 (11%)

Query: 56   IADKVDAAQMP--QEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL-QD 112
            + +KV+A +    ++ +K+Q    S +  +E+M       ++ ++   Q++    +  Q 
Sbjct: 755  LKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQL 814

Query: 113  VSMKFRLFQKPAN---FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 169
            +S +    +   N   F  +LQ+ + +    +  L    T   E   ++SQL  C +   
Sbjct: 815  LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 874

Query: 170  SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 229
             LS ++ ++E +    + I  K++ + P  LD    A   H+ ++ + V  R+++L+   
Sbjct: 875  RLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIF 932

Query: 230  KLSRKMR--KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 287
                 MR  + M+ +  W+  ++ +L+           ++  +   +A Q  +++Q+  L
Sbjct: 933  DTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGL 992

Query: 288  KSI-TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 346
              + T V E  K    +     + +   +   W  ++S+  E    L E    +     +
Sbjct: 993  YYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 1052

Query: 347  VDHITKWIIQADTLLDE-------SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 399
            +  + KW+ + D  L E       SE  K Q K+   + L +++  I+P ++S  +    
Sbjct: 1053 IQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQ--CRLLVSDIQTIQPSLNSVNEGGQK 1110

Query: 400  LMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE 459
            +           +E ++ ELN ++  +  ++   K ++    LE+  S  + L E  E  
Sbjct: 1111 IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALK-GGLEKTVSLQKDLSEMHEWM 1169

Query: 460  IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDER----------------KR 503
             Q      E DF     ++ +  V+E+ +  +  QQ+    +                 +
Sbjct: 1170 TQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1229

Query: 504  EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 563
            E +K + + L T +  L    + + K   E+   W++     +   K L+++E KL +  
Sbjct: 1230 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTE 1289

Query: 564  E-PRDERKIKEI----DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-LSKRWRE 617
              P    +I E+    +  ++  ++  N +R  A+ L++ G    +   +++  + RWRE
Sbjct: 1290 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1349

Query: 618  IESKFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 676
            +  +  + ++L    I + +E E  + + ++    I    + Y+ +    +Q   E +++
Sbjct: 1350 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI 1409

Query: 677  LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 736
             +          DL   E SL+ +K   Q           K+ A             Q  
Sbjct: 1410 QS----------DLTSHEISLEEMKKHNQ----------GKEAA-------------QRV 1436

Query: 737  LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL--RKTQIPEN 794
            LSQ+D   +K+    +D   +F R  +K   F   ++     L E +  L   +T+  E 
Sbjct: 1437 LSQIDVAQKKL----QDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1491

Query: 795  WEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 854
                    +   L   + + ++ V  +  TG +I+Q+    +   L E++ +L L + E+
Sbjct: 1492 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1551

Query: 855  CKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVK 913
              ++++RK++LE+   +  + ++++N    WL   D  +       G    L  ++   K
Sbjct: 1552 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGK 1611

Query: 914  LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 973
               +E+  ++  LK + E G  +     +  +++  +E+KL   N  WI V+        
Sbjct: 1612 ATQKEIEKQKVHLKSITEVGEAL---KTVLGKKETLVEDKLSLLNSNWIAVT-------S 1661

Query: 974  EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV-QETEIAVQ 1032
              E  +  L + +K +E  ++ ++H+  W+      L+   +   +   DV +  +  + 
Sbjct: 1662 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELN 1721

Query: 1033 AKQPDVEEILSKGQHLYKEK--PATQPVKRKLEDLSSEWKAVNRLLQELRAKQP--DLAP 1088
              +P V+    +  +L   +     + V+ ++ +L+  + A++  ++  +A  P  +L  
Sbjct: 1722 DIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQ 1781

Query: 1089 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 1148
              + I          + Q V  KE   +K     +       L   +     +TD     
Sbjct: 1782 FNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKRE 1841

Query: 1149 DQVIKSQRVMV--GDLEDINEMIIKQKATM-QDLEQRRPQLEELITAAQNLKNK-TSNQE 1204
            +  IK Q +      L+D+     K+   +     Q + Q ++L+    +++ K  S  E
Sbjct: 1842 EIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPE 1901

Query: 1205 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKD-------------STQWLE----- 1246
             R     +I+ I  +  + +E L   R+Q   + +D             S +W E     
Sbjct: 1902 PRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKF 1959

Query: 1247 -------------AKEEAEQVLGQARAKLESWKEGPYTVDA--IQKKITETKQL------ 1285
                          +EE   V+ +      S+    Y  +   + + + E +QL      
Sbjct: 1960 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 2019

Query: 1286 -AKD-----------------LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA 1327
             AKD                 L+Q    +D+ +      L+  +  +  K+      ++ 
Sbjct: 2020 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDF 2079

Query: 1328 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 1387
             W  ++K   +R+   + +    ++F  D++ F  WLTEAE          RK ++ E+ 
Sbjct: 2080 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-------QFLRKTQIPENW 2132

Query: 1388 KGVKELMKQW--QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 1445
            +  K    +W  ++LQ  I     V   L+   ++I++      DA +LQ +L ++N +W
Sbjct: 2133 EHAK---YKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ-SSKTDASILQEKLGSLNLRW 2188

Query: 1446 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 1505
             E+ K+  + +  LE   +        L E ++WL+  D+  S     G +    +K   
Sbjct: 2189 QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ 2248

Query: 1506 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 1565
            V +    EL  ++ ++    ET    L   P+              PEE+ +     L  
Sbjct: 2249 V-KLLVEELPLRQGILKQLNETGGPVLVSAPIS-------------PEEQDK-----LEN 2289

Query: 1566 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDL 1625
            + ++ N +W K++    + Q +I+  ++ L +L++  ++L+ +L    +     +   ++
Sbjct: 2290 KLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEI 2349

Query: 1626 LIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKL 1685
                 Q+    V+     +   + +V  +    + L        P     LEDL++ WK 
Sbjct: 2350 YNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK-RKLEDLSSEWK- 2407

Query: 1686 LQVAVEDRVRQLHEAHRDFGP------ASQHFLSTSVQGP---WERAISPNKVPYYINHE 1736
               AV   +++L     D  P      AS     T V  P    E AIS  ++P  +  E
Sbjct: 2408 ---AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 2464

Query: 1737 TQTTCWDHPKMTELYQSLADLNNV 1760
                   +   TEL   L+ L+ V
Sbjct: 2465 VPALADFNRAWTELTDWLSLLDQV 2488



 Score =  157 bits (396), Expect = 2e-37
 Identities = 333/1864 (17%), Positives = 730/1864 (39%), Gaps = 289/1864 (15%)

Query: 15   LNAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 74
            L  +R Q+ +       Q++E  L + Q S+T  D ++      ++ A Q   + Q  QS
Sbjct: 935  LPPMRYQETMSAIRTWVQQSETKLSIPQLSVT--DYEIMEQRLGELQALQSSLQEQ--QS 990

Query: 75   DLTSHEISLEEMKKH--NQGKEAAQRVLSQIDVAQKKLQDVSMKF-----RLFQKPANFE 127
             L     +++EM K   ++     Q    +I+   KKL    ++          K    +
Sbjct: 991  GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQ 1050

Query: 128  QRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQ 187
              +Q  K  + EV + L        + E+++ QL  C  L   +  ++  +  V + G++
Sbjct: 1051 NHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQK 1110

Query: 188  IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 247
            I  + + E    L+  +  L   ++ +  +V  RK+ L+  L+ +  ++K+++ + EW+ 
Sbjct: 1111 IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMT 1170

Query: 248  ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE------------VGE 295
              + E  +R      P  L   V   K  ++E ++++  +K +TE              E
Sbjct: 1171 QAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQE 1230

Query: 296  ALKTVLGKKE-------TLVEDKLSLLNSNW------IAVTSRAEEWLNLLLEYQKHMET 342
            ALK  L           T +  K   L   W      ++   +A +WLN +    K  E 
Sbjct: 1231 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTEN 1290

Query: 343  FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLK--AELNDIRPKVDSTRDQAANL 400
                 + I++ +   + L+  SE   P Q   + + L     ++++  +   T +     
Sbjct: 1291 IPGGAEEISEVLDSLENLMRHSE-DNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1349

Query: 401  MANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSD-IQKLLEPLEAE 459
            +       +KL+E  I        ++ H I+     I  K+L  + +D +     P EA+
Sbjct: 1350 LHEEAVRRQKLLEQSIQSAQETEKSL-HLIQESLTFID-KQLAAYIADKVDAAQMPQEAQ 1407

Query: 460  IQQGVNLKEEDFNKDMNEDNEGTVK----------------------ELLQRGDNLQQRI 497
              Q      E   ++M + N+G                          L Q+  N +QR+
Sbjct: 1408 KIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRL 1467

Query: 498  TDERK-REEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKC-LDDI 555
             + +   +E+K+    L+TK    + ++SQ     + +     + K + + ++K     +
Sbjct: 1468 QESKMILDEVKMHLPALETKSVEQEVVQSQ-LNHCVNLYKSLSEVKSEVEMVIKTGRQIV 1526

Query: 556  EKKLASLPEPRDER-------------KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAM 602
            +KK    P+  DER             K+ E  ++L+K  +    +R++   L+E  AA 
Sbjct: 1527 QKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAAT 1586

Query: 603  AVE----------PTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTE------ 646
             +E          P+ +     W +   K  + ++++   I  V E    V+ +      
Sbjct: 1587 DMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVE 1646

Query: 647  ---------------------DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 685
                                 ++ LE      T+   + H+++ +++ + LL+  +    
Sbjct: 1647 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1706

Query: 686  DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 745
                  ++E+ LK +K  L     ++D    +    + +     R  ++  +S+L+ ++ 
Sbjct: 1707 Q-----QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFA 1761

Query: 746  KVNKMYKDRQGRFDRSVEKWRRFHYDI-KIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL 804
             ++  ++ + G+    +++  +F+ DI K+      E +Q +          + K + + 
Sbjct: 1762 AIS--HRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGV----------NLKEEDFN 1809

Query: 805  KEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKK 863
            K++ +D  G  + +++  +   + I  +  + +  I Q+ L + +   +++    S R+K
Sbjct: 1810 KDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL---RSQRRK 1866

Query: 864  RLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLR 922
            +  E  +   +++R  ++ +  L++ +  +AS+P EP  E+++KE   +++   EEL   
Sbjct: 1867 KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP-EPRDERKIKEIDRELQKKKEELNAV 1925

Query: 923  QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 982
            +   + L+E G  + V            E    Q + +W ++     + +    AQI  +
Sbjct: 1926 RRQAEGLSEDGAAMAV------------EPTQIQLSKRWREIESKFAQFRRLNFAQIHTV 1973

Query: 983  GQ--LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEE 1040
             +  +    ED+  +++++     P     EI +    +   +V++   A      D E+
Sbjct: 1974 REETMMVMTEDMPLEISYV-----PSTYLTEITHV--SQALLEVEQLLNAPDLCAKDFED 2026

Query: 1041 ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQT 1100
            +  + + L   K + Q    +++ + S+  A  +                    A+P + 
Sbjct: 2027 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQ-------------------SATPVER 2067

Query: 1101 VTLVTQPVVTKETAISKLEMPSSLMLEV--PALADFNRA---WTE-------LTDWLSLL 1148
            V L        + A+S+L+     + ++       F+R+   W            WL+  
Sbjct: 2068 VKL--------QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEA 2119

Query: 1149 DQVIKSQRVMVGDLEDINEMIIKQKATMQD-LEQRRPQLEELITAAQNLKNKTSNQEART 1207
            +Q ++  ++         +  +K+   +QD + QR+  +  L    + +  ++S  +A +
Sbjct: 2120 EQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDA-S 2175

Query: 1208 IITDRIERIQNQWDEVQEHLQNRRQQ-------LNEMLKDSTQWLEAKEEAEQVLGQARA 1260
            I+ +++  +  +W EV + L +R+++       L+E  +D  +++   EEA+ +   A  
Sbjct: 2176 ILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI---ASI 2232

Query: 1261 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL--RDYSADDTRKV 1318
             LE  KE       +++K+ + K L ++L   Q  +   N+    +L     S ++  K+
Sbjct: 2233 PLEPGKE-----QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2287

Query: 1319 HMITENINASWRSIHKRVSEREAALE-------ETHRLLQQFPLDLEKFLAWL------- 1364
                +  N  W  + + + E++  +E       +  + L+     L   L WL       
Sbjct: 2288 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2347

Query: 1365 ----------------TEAETTA---NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIE 1405
                            TE    A   +V +  ++ + L ++    + + ++ +DL  E +
Sbjct: 2348 EIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWK 2407

Query: 1406 AHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQ 1465
            A   +   L      +   L     +      L        E     L + S L      
Sbjct: 2408 AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA 2467

Query: 1466 WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTL 1525
                + +  EL  WL L D  +  Q  + GD   + +     +A  ++L+ + P      
Sbjct: 2468 LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP------ 2521

Query: 1526 ETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQ 1585
                          LE+L    + L  +   Q    ++  + E +  +W+++  H  + +
Sbjct: 2522 -------------QLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRR 2568

Query: 1586 RKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIA 1645
            ++++E L+   +  EA +E +  L QA     SW+  G   +D++Q  + + K L  ++ 
Sbjct: 2569 QQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE-GPYTVDAIQKKITETKQLAKDLR 2627

Query: 1646 PLKENVSHVNDLARQLTTLGIQLSPYNLS-------TLEDLNTRWKLLQVAVEDRVRQLH 1698
              + NV   NDLA +L      L  Y+           E++N  W+ +   V +R   L 
Sbjct: 2628 QWQTNVDVANDLALKL------LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2681

Query: 1699 EAHR 1702
            E HR
Sbjct: 2682 ETHR 2685



 Score =  107 bits (266), Expect = 2e-22
 Identities = 244/1327 (18%), Positives = 522/1327 (39%), Gaps = 212/1327 (15%)

Query: 304  KETLVEDKLSLLNSNWIAV-TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 362
            +ET V+++++LLNS W  +  +  E+  NL   ++  M+  +Q +  +  W+ + +    
Sbjct: 412  EETEVQEQMNLLNSRWECLRVASMEKQSNL---HRVLMDLQNQKLKELNDWLTKTEERTR 468

Query: 363  ESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 415
            + E++      + LKR       L+ +L   + +V+S       +  + GDH    +E Q
Sbjct: 469  KMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ 528

Query: 416  ISELNHRFAAISHRIKTGKASIPLKELE---QFNSDIQKLLEPLEAEIQQGVNLKEEDFN 472
            +  L  R+A I     T    + L+++    Q  ++ Q L     +E +  VN       
Sbjct: 529  LKVLGDRWANICRW--TEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 586

Query: 473  KDMNEDNEGTVKELLQRGDNLQQRITDERKREEI----KIKQQLLQTKHNALKDLRSQRR 528
            KD NE      K  + + D        E+K++ +     +KQ LL T  N          
Sbjct: 587  KDQNEMLSSLQKLAVLKADL-------EKKKQSMGKLYSLKQDLLSTLKN---------- 629

Query: 529  KKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 588
            K   + +  W       D+  +C D++ +KL        E+   +I + +   +  L   
Sbjct: 630  KSVTQKTEAWL------DNFARCWDNLVQKL--------EKSTAQISQAVTTTQPSLTQT 675

Query: 589  RRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDM 648
                     +         QI +     E+     Q +R    QI TV  E    +  D 
Sbjct: 676  TVM------ETVTTVTTREQILVKHAQEELPPPPPQKKR----QI-TVDSEIRKRLDVD- 723

Query: 649  PLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSS 708
                          IT +   +   E +L +P+        +F++E +  ++K+ +    
Sbjct: 724  --------------ITELHSWITRSEAVLQSPEFA------IFRKEGNFSDLKEKVNA-- 761

Query: 709  GRIDIIHSKKTAALQSATP-------------VERVKLQEALSQLDFQWEKVNKMYKDRQ 755
              I+   ++K   LQ A+              V    +++A  QL+ +W +  ++  +R 
Sbjct: 762  --IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERL 819

Query: 756  GRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW---------EHAKYKWYLKE 806
                     W  +  +I  F   L + EQ    T   ENW         E    K  LK 
Sbjct: 820  N--------WLEYQNNIIAFYNQLQQLEQM---TTTAENWLKIQPTTPSEPTAIKSQLKI 868

Query: 807  LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASI-LQEKLGSLNLRWQEVCKQLSDRKKRL 865
             +D + +   +   +     + I    K    + L     +    +++V   +  R+K L
Sbjct: 869  CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKEL 928

Query: 866  EEQKNILS--EFQRDLNEFVLWLEEADNIASIP-LEPGKEQQLKEKLEQVKLLVEELPLR 922
            +   + L    +Q  ++    W+++++   SIP L     + ++++L +++ L   L  +
Sbjct: 929  QTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQ 988

Query: 923  QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 982
            Q  L  L+ T   +   AP   E   K +++ ++   +W K+S  L E   ++E Q+  L
Sbjct: 989  QSGLYYLSTTVKEMSKKAP--SEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKL 1046

Query: 983  GQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 1039
             +++  ++ L++ +  + ++L    P     EI  +  ++    V +    +Q  QP + 
Sbjct: 1047 RKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD----IQTIQPSLN 1102

Query: 1040 EILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 1097
             +   GQ +  E        ++ +L++L+++W   + + Q++ A++  L  GL       
Sbjct: 1103 SVNEGGQKIKNEAEPEFASRLETELKELNTQW---DHMCQQVYARKEALKGGLE------ 1153

Query: 1098 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 1157
             +TV+L                                +  +E+ +W++  ++    +  
Sbjct: 1154 -KTVSL-------------------------------QKDLSEMHEWMTQAEEEYLERDF 1181

Query: 1158 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 1217
                 +++ + + + K   ++ +Q+  +++ L+T + N     +   A+  +   +E + 
Sbjct: 1182 EYKTPDELQKAVEEMKRAKEEAQQKEAKVK-LLTESVNSVIAQAPPVAQEALKKELETLT 1240

Query: 1218 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 1277
              +  +   L  + + L E+     + L   E+A + L +   KL++ +  P   + I +
Sbjct: 1241 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1300

Query: 1278 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 1337
             +   + L   +R  + N +    LA  L      D+   ++   E  N+ WR +H+   
Sbjct: 1301 VLDSLENL---MRHSEDNPNQIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAV 1355

Query: 1338 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1397
             R+  LE++ +  Q    + EK L  + E+ T  +      +    + D     ++ ++ 
Sbjct: 1356 RRQKLLEQSIQSAQ----ETEKSLHLIQESLTFID-----KQLAAYIADKVDAAQMPQEA 1406

Query: 1398 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1457
            Q +Q ++ +H      + +++Q    +        + Q++L +++ K+  L +K  N   
Sbjct: 1407 QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQ 1465

Query: 1458 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1517
             L+ S        + L E+ + L   + +   Q  +      +    +++++        
Sbjct: 1466 RLQESK-------MILDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEVKSEV 1515

Query: 1518 EPVIMSTLETVRIFLTEQPLEGLE-----KLYQEPRELPPEERAQNVTRLL---RKQAEE 1569
            E VI +  + V+   TE P E  E     KL+         ER Q + + L   RK  +E
Sbjct: 1516 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1575

Query: 1570 VN--TEW 1574
            +N  TEW
Sbjct: 1576 MNVLTEW 1582



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 190/965 (19%), Positives = 382/965 (39%), Gaps = 98/965 (10%)

Query: 778  WLTEAEQFLR-KTQIPENWEHAKYKWYLKE--LQDGIGQRQTVVRTLNATGEEIIQQS-- 832
            WL  AE  L+ + +I  + E  K +++  E  + D +   Q  V  +   G ++I     
Sbjct: 350  WLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD-LTAHQGRVGNILQLGSKLIGTGKL 408

Query: 833  SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWL----EE 888
            S+ + + +QE++  LN RW+  C +++  +K+    + ++    + L E   WL    E 
Sbjct: 409  SEDEETEVQEQMNLLNSRWE--CLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEER 466

Query: 889  ADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD 948
               +   PL P  E  LK +++Q K+L E+L   Q  +  L  T   V+V          
Sbjct: 467  TRKMEEEPLGPDLED-LKRQVQQHKVLQEDLEQEQVRVNSL--THMVVVVDESSGDHATA 523

Query: 949  KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 1008
             LE +LK    +W  + R   ++   ++        +  K + L E+      WLS    
Sbjct: 524  ALEEQLKVLGDRWANICRWTEDRWVLLQ-------DILLKWQRLTEEQCLFSAWLS---E 573

Query: 1009 QLEIYNQPNQEGPFDVQETEIAVQA----------KQPDVEEILSKGQHLY---KEKPAT 1055
            + +  N+ +  G  D  E   ++Q           K+  + ++ S  Q L    K K  T
Sbjct: 574  KEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT 633

Query: 1056 QPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI 1115
            Q  +  L++ +  W   + L+Q+L      ++  +TT   S TQT  + T   VT    I
Sbjct: 634  QKTEAWLDNFARCW---DNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQI 690

Query: 1116 ----SKLEMPS-------SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMV----G 1160
                ++ E+P         + ++       +   TEL  W++  + V++S    +    G
Sbjct: 691  LVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEG 750

Query: 1161 DLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART-IITDRIERIQNQ 1219
            +  D+ E   K  A  ++  ++  +L++   +AQ L  +  N+      I    E++ ++
Sbjct: 751  NFSDLKE---KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 807

Query: 1220 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 1279
            W E  + L  R   L E   +   +    ++ EQ+   A   L+     P    AI+ ++
Sbjct: 808  WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 866

Query: 1280 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 1339
               K     L   Q  ++     ++ L              +       ++ +   V  R
Sbjct: 867  KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA--FTNHFKQVFSDVQAR 924

Query: 1340 EAALEETHRLL--QQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1397
            E  L+     L   ++   +     W+ ++ET  ++ Q +     ++E   G      + 
Sbjct: 925  EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG------EL 978

Query: 1398 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1457
            Q LQ  ++      + L    +++ +    S+ +   Q   + +  +W +L  + +    
Sbjct: 979  QALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1037

Query: 1458 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1517
             LE   ++ +++   +Q L  W+   D  L  + P  GD   ++KQ    R    +++T 
Sbjct: 1038 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 1097

Query: 1518 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 1577
            +P + S              EG +K+     E  PE  ++     L  + +E+NT+W+ +
Sbjct: 1098 QPSLNSV------------NEGGQKI---KNEAEPEFASR-----LETELKELNTQWDHM 1137

Query: 1578 NLHSADWQRKIDETLERLQELQEATDELDLKLRQA--EVIKGSWQPVGDLLIDSLQDHLE 1635
                   +  +   LE+   LQ+   E+   + QA  E ++  ++       D LQ  +E
Sbjct: 1138 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP---DELQKAVE 1194

Query: 1636 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRV 1694
            ++K  + E    +  V  + +    +      ++   L   LE L T ++ L   +  + 
Sbjct: 1195 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1254

Query: 1695 RQLHE 1699
            + L E
Sbjct: 1255 KTLEE 1259



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 76/369 (20%), Positives = 140/369 (37%), Gaps = 28/369 (7%)

Query: 1098 TQTVTLVTQPVVTKETAISKLEMP------SSLMLEVPALADFNRAWTELTDWLSLLDQV 1151
            TQ   + T            LE P      SSLM     L  +  A  E+  WL   +  
Sbjct: 298  TQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDT 357

Query: 1152 IKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNL--------KNKTSNQ 1203
            +++Q  +  D+E + +     +  M DL   + ++  ++     L          +T  Q
Sbjct: 358  LQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQ 417

Query: 1204 EARTIITDRIERIQNQWDEVQEHLQNRRQQL-NEMLKDSTQWLEAKEEAEQVLGQARAKL 1262
            E   ++  R E ++    E Q +L      L N+ LK+   WL   EE  +       K+
Sbjct: 418  EQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTR-------KM 470

Query: 1263 ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMIT 1322
            E    GP  ++ +++++ + K L +DL Q Q  V+    + + +        T  +    
Sbjct: 471  EEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQL 529

Query: 1323 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1382
            + +   W +I +   +R   L++     Q+   +   F AWL+E E   N +     K  
Sbjct: 530  KVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFK-- 587

Query: 1383 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1442
               D   +   +++   L+ ++E        L    Q +L +L+        +  LDN  
Sbjct: 588  ---DQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 644

Query: 1443 FKWSELRKK 1451
              W  L +K
Sbjct: 645  RCWDNLVQK 653



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)

Query: 1405 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 1459
            E H  ++H +  + Q  +   +G +     + R  +  +  +     S   RS     HL
Sbjct: 259  EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 318

Query: 1460 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 1507
            EA  D+              R   +L+E+L WL   +D L  Q  I  D   V+ Q   H
Sbjct: 319  EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 378

Query: 1508 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 1567
              +  +L   +  + + L+          L G  KL ++      EE        +++Q 
Sbjct: 379  EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 420

Query: 1568 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 1622
              +N+ WE L + S + Q  +   L     ++L+EL +   + + + R+ E      +P+
Sbjct: 421  NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 475

Query: 1623 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 1678
            G  L D L+  +++ K L+ +   L++    VN L   +  +      +  + LE+    
Sbjct: 476  GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 531

Query: 1679 LNTRWKLLQVAVEDR 1693
            L  RW  +    EDR
Sbjct: 532  LGDRWANICRWTEDR 546


>gi|5032285 dystrophin Dp427l isoform [Homo sapiens]
          Length = 3562

 Score = 4597 bits (11923), Expect = 0.0
 Identities = 2328/2328 (100%), Positives = 2328/2328 (100%)

Query: 17   AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL 76
            AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL
Sbjct: 1235 AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL 1294

Query: 77   TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 136
            TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI
Sbjct: 1295 TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1354

Query: 137  LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 196
            LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN
Sbjct: 1355 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1414

Query: 197  PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 256
            PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR
Sbjct: 1415 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1474

Query: 257  SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN 316
            SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN
Sbjct: 1475 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN 1534

Query: 317  SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL 376
            SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL
Sbjct: 1535 SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL 1594

Query: 377  KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS 436
            KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS
Sbjct: 1595 KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS 1654

Query: 437  IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 496
            IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR
Sbjct: 1655 IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1714

Query: 497  ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 556
            ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE
Sbjct: 1715 ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 1774

Query: 557  KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR 616
            KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR
Sbjct: 1775 KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR 1834

Query: 617  EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 676
            EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL
Sbjct: 1835 EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 1894

Query: 677  LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 736
            LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA
Sbjct: 1895 LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 1954

Query: 737  LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE 796
            LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE
Sbjct: 1955 LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE 2014

Query: 797  HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK 856
            HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK
Sbjct: 2015 HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK 2074

Query: 857  QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV 916
            QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV
Sbjct: 2075 QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV 2134

Query: 917  EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE 976
            EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE
Sbjct: 2135 EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE 2194

Query: 977  AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 1036
            AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP
Sbjct: 2195 AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 2254

Query: 1037 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 1096
            DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS
Sbjct: 2255 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 2314

Query: 1097 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 1156
            PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR
Sbjct: 2315 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 2374

Query: 1157 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 1216
            VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI
Sbjct: 2375 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 2434

Query: 1217 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 1276
            QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ
Sbjct: 2435 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 2494

Query: 1277 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV 1336
            KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV
Sbjct: 2495 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV 2554

Query: 1337 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 1396
            SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ
Sbjct: 2555 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 2614

Query: 1397 WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR 1456
            WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR
Sbjct: 2615 WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR 2674

Query: 1457 SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 1516
            SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT
Sbjct: 2675 SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 2734

Query: 1517 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 1576
            KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK
Sbjct: 2735 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 2794

Query: 1577 LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK 1636
            LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK
Sbjct: 2795 LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK 2854

Query: 1637 VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 1696
            VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ
Sbjct: 2855 VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 2914

Query: 1697 LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD 1756
            LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD
Sbjct: 2915 LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD 2974

Query: 1757 LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI 1816
            LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI
Sbjct: 2975 LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI 3034

Query: 1817 YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY 1876
            YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY
Sbjct: 3035 YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY 3094

Query: 1877 LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE 1936
            LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE
Sbjct: 3095 LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE 3154

Query: 1937 AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC 1996
            AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC
Sbjct: 3155 AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC 3214

Query: 1997 QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV 2056
            QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV
Sbjct: 3215 QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV 3274

Query: 2057 QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND 2116
            QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND
Sbjct: 3275 QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND 3334

Query: 2117 SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN 2176
            SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN
Sbjct: 3335 SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN 3394

Query: 2177 RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 2236
            RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ
Sbjct: 3395 RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 3454

Query: 2237 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 2296
            ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS
Sbjct: 3455 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 3514

Query: 2297 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2344
            DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 3515 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 3562



 Score =  186 bits (473), Expect = 2e-46
 Identities = 339/1824 (18%), Positives = 721/1824 (39%), Gaps = 209/1824 (11%)

Query: 56   IADKVDAAQMP--QEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL-QD 112
            + +KV+A +    ++ +K+Q    S +  +E+M       ++ ++   Q++    +  Q 
Sbjct: 636  LKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQL 695

Query: 113  VSMKFRLFQKPAN---FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 169
            +S +    +   N   F  +LQ+ + +    +  L    T   E   ++SQL  C +   
Sbjct: 696  LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 755

Query: 170  SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 229
             LS ++ ++E +    + I  K++ + P  LD    A   H+ ++ + V  R+++L+   
Sbjct: 756  RLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIF 813

Query: 230  KLSRKMR--KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 287
                 MR  + M+ +  W+  ++ +L+           ++  +   +A Q  +++Q+  L
Sbjct: 814  DTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGL 873

Query: 288  KSI-TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 346
              + T V E  K    +     + +   +   W  ++S+  E    L E    +     +
Sbjct: 874  YYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 933

Query: 347  VDHITKWIIQADTLLDE-------SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 399
            +  + KW+ + D  L E       SE  K Q K+   + L +++  I+P ++S  +    
Sbjct: 934  IQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQ--CRLLVSDIQTIQPSLNSVNEGGQK 991

Query: 400  LMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE 459
            +           +E ++ ELN ++  +  ++   K ++    LE+  S  + L E  E  
Sbjct: 992  IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALK-GGLEKTVSLQKDLSEMHEWM 1050

Query: 460  IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDER----------------KR 503
             Q      E DF     ++ +  V+E+ +  +  QQ+    +                 +
Sbjct: 1051 TQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1110

Query: 504  EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 563
            E +K + + L T +  L    + + K   E+   W++     +   K L+++E KL +  
Sbjct: 1111 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTE 1170

Query: 564  E-PRDERKIKEI----DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-LSKRWRE 617
              P    +I E+    +  ++  ++  N +R  A+ L++ G    +   +++  + RWRE
Sbjct: 1171 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1230

Query: 618  IESKFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 676
            +  +  + ++L    I + +E E  + + ++    I    + Y+ +    +Q   E +++
Sbjct: 1231 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI 1290

Query: 677  LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 736
             +          DL   E SL+ +K   Q           K+ A             Q  
Sbjct: 1291 QS----------DLTSHEISLEEMKKHNQ----------GKEAA-------------QRV 1317

Query: 737  LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL--RKTQIPEN 794
            LSQ+D   +K+    +D   +F R  +K   F   ++     L E +  L   +T+  E 
Sbjct: 1318 LSQIDVAQKKL----QDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1372

Query: 795  WEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 854
                    +   L   + + ++ V  +  TG +I+Q+    +   L E++ +L L + E+
Sbjct: 1373 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1432

Query: 855  CKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVK 913
              ++++RK++LE+   +  + ++++N    WL   D  +       G    L  ++   K
Sbjct: 1433 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGK 1492

Query: 914  LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 973
               +E+  ++  LK + E G  +     +  +++  +E+KL   N  WI V+        
Sbjct: 1493 ATQKEIEKQKVHLKSITEVGEAL---KTVLGKKETLVEDKLSLLNSNWIAVT-------S 1542

Query: 974  EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV-QETEIAVQ 1032
              E  +  L + +K +E  ++ ++H+  W+      L+   +   +   DV +  +  + 
Sbjct: 1543 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELN 1602

Query: 1033 AKQPDVEEILSKGQHLYKEK--PATQPVKRKLEDLSSEWKAVNRLLQELRAKQP--DLAP 1088
              +P V+    +  +L   +     + V+ ++ +L+  + A++  ++  +A  P  +L  
Sbjct: 1603 DIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQ 1662

Query: 1089 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 1148
              + I          + Q V  KE   +K     +       L   +     +TD     
Sbjct: 1663 FNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKRE 1722

Query: 1149 DQVIKSQRVMV--GDLEDINEMIIKQKATM-QDLEQRRPQLEELITAAQNLKNK-TSNQE 1204
            +  IK Q +      L+D+     K+   +     Q + Q ++L+    +++ K  S  E
Sbjct: 1723 EIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPE 1782

Query: 1205 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKD-------------STQWLE----- 1246
             R     +I+ I  +  + +E L   R+Q   + +D             S +W E     
Sbjct: 1783 PRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKF 1840

Query: 1247 -------------AKEEAEQVLGQARAKLESWKEGPYTVDA--IQKKITETKQL------ 1285
                          +EE   V+ +      S+    Y  +   + + + E +QL      
Sbjct: 1841 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 1900

Query: 1286 -AKD-----------------LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA 1327
             AKD                 L+Q    +D+ +      L+  +  +  K+      ++ 
Sbjct: 1901 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDF 1960

Query: 1328 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 1387
             W  ++K   +R+   + +    ++F  D++ F  WLTEAE          RK ++ E+ 
Sbjct: 1961 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-------QFLRKTQIPENW 2013

Query: 1388 KGVKELMKQW--QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 1445
            +  K    +W  ++LQ  I     V   L+   ++I++      DA +LQ +L ++N +W
Sbjct: 2014 EHAK---YKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ-SSKTDASILQEKLGSLNLRW 2069

Query: 1446 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 1505
             E+ K+  + +  LE   +        L E ++WL+  D+  S     G +    +K   
Sbjct: 2070 QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ 2129

Query: 1506 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 1565
            V +    EL  ++ ++    ET    L   P+              PEE+ +     L  
Sbjct: 2130 V-KLLVEELPLRQGILKQLNETGGPVLVSAPIS-------------PEEQDK-----LEN 2170

Query: 1566 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDL 1625
            + ++ N +W K++    + Q +I+  ++ L +L++  ++L+ +L    +     +   ++
Sbjct: 2171 KLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEI 2230

Query: 1626 LIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKL 1685
                 Q+    V+     +   + +V  +    + L        P     LEDL++ WK 
Sbjct: 2231 YNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK-RKLEDLSSEWK- 2288

Query: 1686 LQVAVEDRVRQLHEAHRDFGP------ASQHFLSTSVQGP---WERAISPNKVPYYINHE 1736
               AV   +++L     D  P      AS     T V  P    E AIS  ++P  +  E
Sbjct: 2289 ---AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 2345

Query: 1737 TQTTCWDHPKMTELYQSLADLNNV 1760
                   +   TEL   L+ L+ V
Sbjct: 2346 VPALADFNRAWTELTDWLSLLDQV 2369



 Score =  157 bits (396), Expect = 2e-37
 Identities = 333/1864 (17%), Positives = 730/1864 (39%), Gaps = 289/1864 (15%)

Query: 15   LNAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 74
            L  +R Q+ +       Q++E  L + Q S+T  D ++      ++ A Q   + Q  QS
Sbjct: 816  LPPMRYQETMSAIRTWVQQSETKLSIPQLSVT--DYEIMEQRLGELQALQSSLQEQ--QS 871

Query: 75   DLTSHEISLEEMKKH--NQGKEAAQRVLSQIDVAQKKLQDVSMKF-----RLFQKPANFE 127
             L     +++EM K   ++     Q    +I+   KKL    ++          K    +
Sbjct: 872  GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQ 931

Query: 128  QRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQ 187
              +Q  K  + EV + L        + E+++ QL  C  L   +  ++  +  V + G++
Sbjct: 932  NHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQK 991

Query: 188  IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 247
            I  + + E    L+  +  L   ++ +  +V  RK+ L+  L+ +  ++K+++ + EW+ 
Sbjct: 992  IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMT 1051

Query: 248  ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE------------VGE 295
              + E  +R      P  L   V   K  ++E ++++  +K +TE              E
Sbjct: 1052 QAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQE 1111

Query: 296  ALKTVLGKKE-------TLVEDKLSLLNSNW------IAVTSRAEEWLNLLLEYQKHMET 342
            ALK  L           T +  K   L   W      ++   +A +WLN +    K  E 
Sbjct: 1112 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTEN 1171

Query: 343  FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLK--AELNDIRPKVDSTRDQAANL 400
                 + I++ +   + L+  SE   P Q   + + L     ++++  +   T +     
Sbjct: 1172 IPGGAEEISEVLDSLENLMRHSE-DNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1230

Query: 401  MANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSD-IQKLLEPLEAE 459
            +       +KL+E  I        ++ H I+     I  K+L  + +D +     P EA+
Sbjct: 1231 LHEEAVRRQKLLEQSIQSAQETEKSL-HLIQESLTFID-KQLAAYIADKVDAAQMPQEAQ 1288

Query: 460  IQQGVNLKEEDFNKDMNEDNEGTVK----------------------ELLQRGDNLQQRI 497
              Q      E   ++M + N+G                          L Q+  N +QR+
Sbjct: 1289 KIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRL 1348

Query: 498  TDERK-REEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKC-LDDI 555
             + +   +E+K+    L+TK    + ++SQ     + +     + K + + ++K     +
Sbjct: 1349 QESKMILDEVKMHLPALETKSVEQEVVQSQ-LNHCVNLYKSLSEVKSEVEMVIKTGRQIV 1407

Query: 556  EKKLASLPEPRDER-------------KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAM 602
            +KK    P+  DER             K+ E  ++L+K  +    +R++   L+E  AA 
Sbjct: 1408 QKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAAT 1467

Query: 603  AVE----------PTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTE------ 646
             +E          P+ +     W +   K  + ++++   I  V E    V+ +      
Sbjct: 1468 DMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVE 1527

Query: 647  ---------------------DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 685
                                 ++ LE      T+   + H+++ +++ + LL+  +    
Sbjct: 1528 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1587

Query: 686  DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 745
                  ++E+ LK +K  L     ++D    +    + +     R  ++  +S+L+ ++ 
Sbjct: 1588 Q-----QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFA 1642

Query: 746  KVNKMYKDRQGRFDRSVEKWRRFHYDI-KIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL 804
             ++  ++ + G+    +++  +F+ DI K+      E +Q +          + K + + 
Sbjct: 1643 AIS--HRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGV----------NLKEEDFN 1690

Query: 805  KEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKK 863
            K++ +D  G  + +++  +   + I  +  + +  I Q+ L + +   +++    S R+K
Sbjct: 1691 KDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL---RSQRRK 1747

Query: 864  RLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLR 922
            +  E  +   +++R  ++ +  L++ +  +AS+P EP  E+++KE   +++   EEL   
Sbjct: 1748 KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP-EPRDERKIKEIDRELQKKKEELNAV 1806

Query: 923  QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 982
            +   + L+E G  + V            E    Q + +W ++     + +    AQI  +
Sbjct: 1807 RRQAEGLSEDGAAMAV------------EPTQIQLSKRWREIESKFAQFRRLNFAQIHTV 1854

Query: 983  GQ--LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEE 1040
             +  +    ED+  +++++     P     EI +    +   +V++   A      D E+
Sbjct: 1855 REETMMVMTEDMPLEISYV-----PSTYLTEITHV--SQALLEVEQLLNAPDLCAKDFED 1907

Query: 1041 ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQT 1100
            +  + + L   K + Q    +++ + S+  A  +                    A+P + 
Sbjct: 1908 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQ-------------------SATPVER 1948

Query: 1101 VTLVTQPVVTKETAISKLEMPSSLMLEV--PALADFNRA---WTE-------LTDWLSLL 1148
            V L        + A+S+L+     + ++       F+R+   W            WL+  
Sbjct: 1949 VKL--------QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEA 2000

Query: 1149 DQVIKSQRVMVGDLEDINEMIIKQKATMQD-LEQRRPQLEELITAAQNLKNKTSNQEART 1207
            +Q ++  ++         +  +K+   +QD + QR+  +  L    + +  ++S  +A +
Sbjct: 2001 EQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDA-S 2056

Query: 1208 IITDRIERIQNQWDEVQEHLQNRRQQ-------LNEMLKDSTQWLEAKEEAEQVLGQARA 1260
            I+ +++  +  +W EV + L +R+++       L+E  +D  +++   EEA+ +   A  
Sbjct: 2057 ILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI---ASI 2113

Query: 1261 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL--RDYSADDTRKV 1318
             LE  KE       +++K+ + K L ++L   Q  +   N+    +L     S ++  K+
Sbjct: 2114 PLEPGKE-----QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2168

Query: 1319 HMITENINASWRSIHKRVSEREAALE-------ETHRLLQQFPLDLEKFLAWL------- 1364
                +  N  W  + + + E++  +E       +  + L+     L   L WL       
Sbjct: 2169 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2228

Query: 1365 ----------------TEAETTA---NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIE 1405
                            TE    A   +V +  ++ + L ++    + + ++ +DL  E +
Sbjct: 2229 EIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWK 2288

Query: 1406 AHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQ 1465
            A   +   L      +   L     +      L        E     L + S L      
Sbjct: 2289 AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA 2348

Query: 1466 WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTL 1525
                + +  EL  WL L D  +  Q  + GD   + +     +A  ++L+ + P      
Sbjct: 2349 LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP------ 2402

Query: 1526 ETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQ 1585
                          LE+L    + L  +   Q    ++  + E +  +W+++  H  + +
Sbjct: 2403 -------------QLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRR 2449

Query: 1586 RKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIA 1645
            ++++E L+   +  EA +E +  L QA     SW+  G   +D++Q  + + K L  ++ 
Sbjct: 2450 QQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE-GPYTVDAIQKKITETKQLAKDLR 2508

Query: 1646 PLKENVSHVNDLARQLTTLGIQLSPYNLS-------TLEDLNTRWKLLQVAVEDRVRQLH 1698
              + NV   NDLA +L      L  Y+           E++N  W+ +   V +R   L 
Sbjct: 2509 QWQTNVDVANDLALKL------LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2562

Query: 1699 EAHR 1702
            E HR
Sbjct: 2563 ETHR 2566



 Score =  107 bits (266), Expect = 2e-22
 Identities = 244/1327 (18%), Positives = 522/1327 (39%), Gaps = 212/1327 (15%)

Query: 304  KETLVEDKLSLLNSNWIAV-TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 362
            +ET V+++++LLNS W  +  +  E+  NL   ++  M+  +Q +  +  W+ + +    
Sbjct: 293  EETEVQEQMNLLNSRWECLRVASMEKQSNL---HRVLMDLQNQKLKELNDWLTKTEERTR 349

Query: 363  ESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 415
            + E++      + LKR       L+ +L   + +V+S       +  + GDH    +E Q
Sbjct: 350  KMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ 409

Query: 416  ISELNHRFAAISHRIKTGKASIPLKELE---QFNSDIQKLLEPLEAEIQQGVNLKEEDFN 472
            +  L  R+A I     T    + L+++    Q  ++ Q L     +E +  VN       
Sbjct: 410  LKVLGDRWANICRW--TEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 467

Query: 473  KDMNEDNEGTVKELLQRGDNLQQRITDERKREEI----KIKQQLLQTKHNALKDLRSQRR 528
            KD NE      K  + + D        E+K++ +     +KQ LL T  N          
Sbjct: 468  KDQNEMLSSLQKLAVLKADL-------EKKKQSMGKLYSLKQDLLSTLKN---------- 510

Query: 529  KKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 588
            K   + +  W       D+  +C D++ +KL        E+   +I + +   +  L   
Sbjct: 511  KSVTQKTEAWL------DNFARCWDNLVQKL--------EKSTAQISQAVTTTQPSLTQT 556

Query: 589  RRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDM 648
                     +         QI +     E+     Q +R    QI TV  E    +  D 
Sbjct: 557  TVM------ETVTTVTTREQILVKHAQEELPPPPPQKKR----QI-TVDSEIRKRLDVD- 604

Query: 649  PLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSS 708
                          IT +   +   E +L +P+        +F++E +  ++K+ +    
Sbjct: 605  --------------ITELHSWITRSEAVLQSPEFA------IFRKEGNFSDLKEKVNA-- 642

Query: 709  GRIDIIHSKKTAALQSATP-------------VERVKLQEALSQLDFQWEKVNKMYKDRQ 755
              I+   ++K   LQ A+              V    +++A  QL+ +W +  ++  +R 
Sbjct: 643  --IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERL 700

Query: 756  GRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW---------EHAKYKWYLKE 806
                     W  +  +I  F   L + EQ    T   ENW         E    K  LK 
Sbjct: 701  N--------WLEYQNNIIAFYNQLQQLEQM---TTTAENWLKIQPTTPSEPTAIKSQLKI 749

Query: 807  LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASI-LQEKLGSLNLRWQEVCKQLSDRKKRL 865
             +D + +   +   +     + I    K    + L     +    +++V   +  R+K L
Sbjct: 750  CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKEL 809

Query: 866  EEQKNILS--EFQRDLNEFVLWLEEADNIASIP-LEPGKEQQLKEKLEQVKLLVEELPLR 922
            +   + L    +Q  ++    W+++++   SIP L     + ++++L +++ L   L  +
Sbjct: 810  QTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQ 869

Query: 923  QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 982
            Q  L  L+ T   +   AP   E   K +++ ++   +W K+S  L E   ++E Q+  L
Sbjct: 870  QSGLYYLSTTVKEMSKKAP--SEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKL 927

Query: 983  GQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 1039
             +++  ++ L++ +  + ++L    P     EI  +  ++    V +    +Q  QP + 
Sbjct: 928  RKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD----IQTIQPSLN 983

Query: 1040 EILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 1097
             +   GQ +  E        ++ +L++L+++W   + + Q++ A++  L  GL       
Sbjct: 984  SVNEGGQKIKNEAEPEFASRLETELKELNTQW---DHMCQQVYARKEALKGGLE------ 1034

Query: 1098 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 1157
             +TV+L                                +  +E+ +W++  ++    +  
Sbjct: 1035 -KTVSL-------------------------------QKDLSEMHEWMTQAEEEYLERDF 1062

Query: 1158 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 1217
                 +++ + + + K   ++ +Q+  +++ L+T + N     +   A+  +   +E + 
Sbjct: 1063 EYKTPDELQKAVEEMKRAKEEAQQKEAKVK-LLTESVNSVIAQAPPVAQEALKKELETLT 1121

Query: 1218 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 1277
              +  +   L  + + L E+     + L   E+A + L +   KL++ +  P   + I +
Sbjct: 1122 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1181

Query: 1278 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 1337
             +   + L   +R  + N +    LA  L      D+   ++   E  N+ WR +H+   
Sbjct: 1182 VLDSLENL---MRHSEDNPNQIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAV 1236

Query: 1338 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1397
             R+  LE++ +  Q    + EK L  + E+ T  +      +    + D     ++ ++ 
Sbjct: 1237 RRQKLLEQSIQSAQ----ETEKSLHLIQESLTFID-----KQLAAYIADKVDAAQMPQEA 1287

Query: 1398 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1457
            Q +Q ++ +H      + +++Q    +        + Q++L +++ K+  L +K  N   
Sbjct: 1288 QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQ 1346

Query: 1458 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1517
             L+ S        + L E+ + L   + +   Q  +      +    +++++        
Sbjct: 1347 RLQESK-------MILDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEVKSEV 1396

Query: 1518 EPVIMSTLETVRIFLTEQPLEGLE-----KLYQEPRELPPEERAQNVTRLL---RKQAEE 1569
            E VI +  + V+   TE P E  E     KL+         ER Q + + L   RK  +E
Sbjct: 1397 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1456

Query: 1570 VN--TEW 1574
            +N  TEW
Sbjct: 1457 MNVLTEW 1463



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 190/965 (19%), Positives = 382/965 (39%), Gaps = 98/965 (10%)

Query: 778  WLTEAEQFLR-KTQIPENWEHAKYKWYLKE--LQDGIGQRQTVVRTLNATGEEIIQQS-- 832
            WL  AE  L+ + +I  + E  K +++  E  + D +   Q  V  +   G ++I     
Sbjct: 231  WLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD-LTAHQGRVGNILQLGSKLIGTGKL 289

Query: 833  SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWL----EE 888
            S+ + + +QE++  LN RW+  C +++  +K+    + ++    + L E   WL    E 
Sbjct: 290  SEDEETEVQEQMNLLNSRWE--CLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEER 347

Query: 889  ADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD 948
               +   PL P  E  LK +++Q K+L E+L   Q  +  L  T   V+V          
Sbjct: 348  TRKMEEEPLGPDLED-LKRQVQQHKVLQEDLEQEQVRVNSL--THMVVVVDESSGDHATA 404

Query: 949  KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 1008
             LE +LK    +W  + R   ++   ++        +  K + L E+      WLS    
Sbjct: 405  ALEEQLKVLGDRWANICRWTEDRWVLLQ-------DILLKWQRLTEEQCLFSAWLS---E 454

Query: 1009 QLEIYNQPNQEGPFDVQETEIAVQA----------KQPDVEEILSKGQHLY---KEKPAT 1055
            + +  N+ +  G  D  E   ++Q           K+  + ++ S  Q L    K K  T
Sbjct: 455  KEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT 514

Query: 1056 QPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI 1115
            Q  +  L++ +  W   + L+Q+L      ++  +TT   S TQT  + T   VT    I
Sbjct: 515  QKTEAWLDNFARCW---DNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQI 571

Query: 1116 ----SKLEMPS-------SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMV----G 1160
                ++ E+P         + ++       +   TEL  W++  + V++S    +    G
Sbjct: 572  LVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEG 631

Query: 1161 DLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART-IITDRIERIQNQ 1219
            +  D+ E   K  A  ++  ++  +L++   +AQ L  +  N+      I    E++ ++
Sbjct: 632  NFSDLKE---KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 688

Query: 1220 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 1279
            W E  + L  R   L E   +   +    ++ EQ+   A   L+     P    AI+ ++
Sbjct: 689  WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 747

Query: 1280 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 1339
               K     L   Q  ++     ++ L              +       ++ +   V  R
Sbjct: 748  KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA--FTNHFKQVFSDVQAR 805

Query: 1340 EAALEETHRLL--QQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1397
            E  L+     L   ++   +     W+ ++ET  ++ Q +     ++E   G      + 
Sbjct: 806  EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG------EL 859

Query: 1398 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1457
            Q LQ  ++      + L    +++ +    S+ +   Q   + +  +W +L  + +    
Sbjct: 860  QALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 918

Query: 1458 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1517
             LE   ++ +++   +Q L  W+   D  L  + P  GD   ++KQ    R    +++T 
Sbjct: 919  KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 978

Query: 1518 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 1577
            +P + S              EG +K+     E  PE  ++     L  + +E+NT+W+ +
Sbjct: 979  QPSLNSV------------NEGGQKI---KNEAEPEFASR-----LETELKELNTQWDHM 1018

Query: 1578 NLHSADWQRKIDETLERLQELQEATDELDLKLRQA--EVIKGSWQPVGDLLIDSLQDHLE 1635
                   +  +   LE+   LQ+   E+   + QA  E ++  ++       D LQ  +E
Sbjct: 1019 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP---DELQKAVE 1075

Query: 1636 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRV 1694
            ++K  + E    +  V  + +    +      ++   L   LE L T ++ L   +  + 
Sbjct: 1076 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1135

Query: 1695 RQLHE 1699
            + L E
Sbjct: 1136 KTLEE 1140



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 76/369 (20%), Positives = 140/369 (37%), Gaps = 28/369 (7%)

Query: 1098 TQTVTLVTQPVVTKETAISKLEMP------SSLMLEVPALADFNRAWTELTDWLSLLDQV 1151
            TQ   + T            LE P      SSLM     L  +  A  E+  WL   +  
Sbjct: 179  TQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDT 238

Query: 1152 IKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNL--------KNKTSNQ 1203
            +++Q  +  D+E + +     +  M DL   + ++  ++     L          +T  Q
Sbjct: 239  LQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQ 298

Query: 1204 EARTIITDRIERIQNQWDEVQEHLQNRRQQL-NEMLKDSTQWLEAKEEAEQVLGQARAKL 1262
            E   ++  R E ++    E Q +L      L N+ LK+   WL   EE  +       K+
Sbjct: 299  EQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTR-------KM 351

Query: 1263 ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMIT 1322
            E    GP  ++ +++++ + K L +DL Q Q  V+    + + +        T  +    
Sbjct: 352  EEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQL 410

Query: 1323 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1382
            + +   W +I +   +R   L++     Q+   +   F AWL+E E   N +     K  
Sbjct: 411  KVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFK-- 468

Query: 1383 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1442
               D   +   +++   L+ ++E        L    Q +L +L+        +  LDN  
Sbjct: 469  ---DQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 525

Query: 1443 FKWSELRKK 1451
              W  L +K
Sbjct: 526  RCWDNLVQK 534



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)

Query: 1405 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 1459
            E H  ++H +  + Q  +   +G +     + R  +  +  +     S   RS     HL
Sbjct: 140  EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 199

Query: 1460 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 1507
            EA  D+              R   +L+E+L WL   +D L  Q  I  D   V+ Q   H
Sbjct: 200  EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 259

Query: 1508 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 1567
              +  +L   +  + + L+          L G  KL ++      EE        +++Q 
Sbjct: 260  EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 301

Query: 1568 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 1622
              +N+ WE L + S + Q  +   L     ++L+EL +   + + + R+ E      +P+
Sbjct: 302  NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 356

Query: 1623 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 1678
            G  L D L+  +++ K L+ +   L++    VN L   +  +      +  + LE+    
Sbjct: 357  GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 412

Query: 1679 LNTRWKLLQVAVEDR 1693
            L  RW  +    EDR
Sbjct: 413  LGDRWANICRWTEDR 427


>gi|5032283 dystrophin Dp427m isoform [Homo sapiens]
          Length = 3685

 Score = 4597 bits (11923), Expect = 0.0
 Identities = 2328/2328 (100%), Positives = 2328/2328 (100%)

Query: 17   AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL 76
            AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL
Sbjct: 1358 AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL 1417

Query: 77   TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 136
            TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI
Sbjct: 1418 TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1477

Query: 137  LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 196
            LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN
Sbjct: 1478 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1537

Query: 197  PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 256
            PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR
Sbjct: 1538 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1597

Query: 257  SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN 316
            SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN
Sbjct: 1598 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN 1657

Query: 317  SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL 376
            SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL
Sbjct: 1658 SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL 1717

Query: 377  KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS 436
            KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS
Sbjct: 1718 KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS 1777

Query: 437  IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 496
            IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR
Sbjct: 1778 IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1837

Query: 497  ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 556
            ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE
Sbjct: 1838 ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 1897

Query: 557  KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR 616
            KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR
Sbjct: 1898 KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR 1957

Query: 617  EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 676
            EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL
Sbjct: 1958 EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 2017

Query: 677  LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 736
            LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA
Sbjct: 2018 LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 2077

Query: 737  LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE 796
            LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE
Sbjct: 2078 LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE 2137

Query: 797  HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK 856
            HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK
Sbjct: 2138 HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK 2197

Query: 857  QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV 916
            QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV
Sbjct: 2198 QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV 2257

Query: 917  EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE 976
            EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE
Sbjct: 2258 EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE 2317

Query: 977  AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 1036
            AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP
Sbjct: 2318 AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 2377

Query: 1037 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 1096
            DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS
Sbjct: 2378 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 2437

Query: 1097 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 1156
            PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR
Sbjct: 2438 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 2497

Query: 1157 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 1216
            VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI
Sbjct: 2498 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 2557

Query: 1217 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 1276
            QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ
Sbjct: 2558 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 2617

Query: 1277 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV 1336
            KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV
Sbjct: 2618 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV 2677

Query: 1337 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 1396
            SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ
Sbjct: 2678 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 2737

Query: 1397 WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR 1456
            WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR
Sbjct: 2738 WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR 2797

Query: 1457 SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 1516
            SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT
Sbjct: 2798 SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 2857

Query: 1517 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 1576
            KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK
Sbjct: 2858 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 2917

Query: 1577 LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK 1636
            LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK
Sbjct: 2918 LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK 2977

Query: 1637 VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 1696
            VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ
Sbjct: 2978 VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 3037

Query: 1697 LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD 1756
            LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD
Sbjct: 3038 LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD 3097

Query: 1757 LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI 1816
            LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI
Sbjct: 3098 LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI 3157

Query: 1817 YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY 1876
            YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY
Sbjct: 3158 YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY 3217

Query: 1877 LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE 1936
            LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE
Sbjct: 3218 LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE 3277

Query: 1937 AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC 1996
            AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC
Sbjct: 3278 AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC 3337

Query: 1997 QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV 2056
            QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV
Sbjct: 3338 QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV 3397

Query: 2057 QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND 2116
            QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND
Sbjct: 3398 QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND 3457

Query: 2117 SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN 2176
            SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN
Sbjct: 3458 SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN 3517

Query: 2177 RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 2236
            RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ
Sbjct: 3518 RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 3577

Query: 2237 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 2296
            ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS
Sbjct: 3578 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 3637

Query: 2297 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2344
            DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 3638 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 3685



 Score =  186 bits (473), Expect = 2e-46
 Identities = 339/1824 (18%), Positives = 721/1824 (39%), Gaps = 209/1824 (11%)

Query: 56   IADKVDAAQMP--QEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL-QD 112
            + +KV+A +    ++ +K+Q    S +  +E+M       ++ ++   Q++    +  Q 
Sbjct: 759  LKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQL 818

Query: 113  VSMKFRLFQKPAN---FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 169
            +S +    +   N   F  +LQ+ + +    +  L    T   E   ++SQL  C +   
Sbjct: 819  LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 878

Query: 170  SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 229
             LS ++ ++E +    + I  K++ + P  LD    A   H+ ++ + V  R+++L+   
Sbjct: 879  RLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIF 936

Query: 230  KLSRKMR--KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 287
                 MR  + M+ +  W+  ++ +L+           ++  +   +A Q  +++Q+  L
Sbjct: 937  DTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGL 996

Query: 288  KSI-TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 346
              + T V E  K    +     + +   +   W  ++S+  E    L E    +     +
Sbjct: 997  YYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 1056

Query: 347  VDHITKWIIQADTLLDE-------SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 399
            +  + KW+ + D  L E       SE  K Q K+   + L +++  I+P ++S  +    
Sbjct: 1057 IQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQ--CRLLVSDIQTIQPSLNSVNEGGQK 1114

Query: 400  LMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE 459
            +           +E ++ ELN ++  +  ++   K ++    LE+  S  + L E  E  
Sbjct: 1115 IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALK-GGLEKTVSLQKDLSEMHEWM 1173

Query: 460  IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDER----------------KR 503
             Q      E DF     ++ +  V+E+ +  +  QQ+    +                 +
Sbjct: 1174 TQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1233

Query: 504  EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 563
            E +K + + L T +  L    + + K   E+   W++     +   K L+++E KL +  
Sbjct: 1234 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTE 1293

Query: 564  E-PRDERKIKEI----DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-LSKRWRE 617
              P    +I E+    +  ++  ++  N +R  A+ L++ G    +   +++  + RWRE
Sbjct: 1294 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1353

Query: 618  IESKFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 676
            +  +  + ++L    I + +E E  + + ++    I    + Y+ +    +Q   E +++
Sbjct: 1354 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI 1413

Query: 677  LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 736
             +          DL   E SL+ +K   Q           K+ A             Q  
Sbjct: 1414 QS----------DLTSHEISLEEMKKHNQ----------GKEAA-------------QRV 1440

Query: 737  LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL--RKTQIPEN 794
            LSQ+D   +K+    +D   +F R  +K   F   ++     L E +  L   +T+  E 
Sbjct: 1441 LSQIDVAQKKL----QDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1495

Query: 795  WEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 854
                    +   L   + + ++ V  +  TG +I+Q+    +   L E++ +L L + E+
Sbjct: 1496 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1555

Query: 855  CKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVK 913
              ++++RK++LE+   +  + ++++N    WL   D  +       G    L  ++   K
Sbjct: 1556 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGK 1615

Query: 914  LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 973
               +E+  ++  LK + E G  +     +  +++  +E+KL   N  WI V+        
Sbjct: 1616 ATQKEIEKQKVHLKSITEVGEAL---KTVLGKKETLVEDKLSLLNSNWIAVT-------S 1665

Query: 974  EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV-QETEIAVQ 1032
              E  +  L + +K +E  ++ ++H+  W+      L+   +   +   DV +  +  + 
Sbjct: 1666 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELN 1725

Query: 1033 AKQPDVEEILSKGQHLYKEK--PATQPVKRKLEDLSSEWKAVNRLLQELRAKQP--DLAP 1088
              +P V+    +  +L   +     + V+ ++ +L+  + A++  ++  +A  P  +L  
Sbjct: 1726 DIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQ 1785

Query: 1089 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 1148
              + I          + Q V  KE   +K     +       L   +     +TD     
Sbjct: 1786 FNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKRE 1845

Query: 1149 DQVIKSQRVMV--GDLEDINEMIIKQKATM-QDLEQRRPQLEELITAAQNLKNK-TSNQE 1204
            +  IK Q +      L+D+     K+   +     Q + Q ++L+    +++ K  S  E
Sbjct: 1846 EIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPE 1905

Query: 1205 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKD-------------STQWLE----- 1246
             R     +I+ I  +  + +E L   R+Q   + +D             S +W E     
Sbjct: 1906 PRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKF 1963

Query: 1247 -------------AKEEAEQVLGQARAKLESWKEGPYTVDA--IQKKITETKQL------ 1285
                          +EE   V+ +      S+    Y  +   + + + E +QL      
Sbjct: 1964 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 2023

Query: 1286 -AKD-----------------LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA 1327
             AKD                 L+Q    +D+ +      L+  +  +  K+      ++ 
Sbjct: 2024 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDF 2083

Query: 1328 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 1387
             W  ++K   +R+   + +    ++F  D++ F  WLTEAE          RK ++ E+ 
Sbjct: 2084 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-------QFLRKTQIPENW 2136

Query: 1388 KGVKELMKQW--QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 1445
            +  K    +W  ++LQ  I     V   L+   ++I++      DA +LQ +L ++N +W
Sbjct: 2137 EHAK---YKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ-SSKTDASILQEKLGSLNLRW 2192

Query: 1446 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 1505
             E+ K+  + +  LE   +        L E ++WL+  D+  S     G +    +K   
Sbjct: 2193 QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ 2252

Query: 1506 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 1565
            V +    EL  ++ ++    ET    L   P+              PEE+ +     L  
Sbjct: 2253 V-KLLVEELPLRQGILKQLNETGGPVLVSAPIS-------------PEEQDK-----LEN 2293

Query: 1566 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDL 1625
            + ++ N +W K++    + Q +I+  ++ L +L++  ++L+ +L    +     +   ++
Sbjct: 2294 KLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEI 2353

Query: 1626 LIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKL 1685
                 Q+    V+     +   + +V  +    + L        P     LEDL++ WK 
Sbjct: 2354 YNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK-RKLEDLSSEWK- 2411

Query: 1686 LQVAVEDRVRQLHEAHRDFGP------ASQHFLSTSVQGP---WERAISPNKVPYYINHE 1736
               AV   +++L     D  P      AS     T V  P    E AIS  ++P  +  E
Sbjct: 2412 ---AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 2468

Query: 1737 TQTTCWDHPKMTELYQSLADLNNV 1760
                   +   TEL   L+ L+ V
Sbjct: 2469 VPALADFNRAWTELTDWLSLLDQV 2492



 Score =  157 bits (396), Expect = 2e-37
 Identities = 333/1864 (17%), Positives = 730/1864 (39%), Gaps = 289/1864 (15%)

Query: 15   LNAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 74
            L  +R Q+ +       Q++E  L + Q S+T  D ++      ++ A Q   + Q  QS
Sbjct: 939  LPPMRYQETMSAIRTWVQQSETKLSIPQLSVT--DYEIMEQRLGELQALQSSLQEQ--QS 994

Query: 75   DLTSHEISLEEMKKH--NQGKEAAQRVLSQIDVAQKKLQDVSMKF-----RLFQKPANFE 127
             L     +++EM K   ++     Q    +I+   KKL    ++          K    +
Sbjct: 995  GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQ 1054

Query: 128  QRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQ 187
              +Q  K  + EV + L        + E+++ QL  C  L   +  ++  +  V + G++
Sbjct: 1055 NHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQK 1114

Query: 188  IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 247
            I  + + E    L+  +  L   ++ +  +V  RK+ L+  L+ +  ++K+++ + EW+ 
Sbjct: 1115 IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMT 1174

Query: 248  ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE------------VGE 295
              + E  +R      P  L   V   K  ++E ++++  +K +TE              E
Sbjct: 1175 QAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQE 1234

Query: 296  ALKTVLGKKE-------TLVEDKLSLLNSNW------IAVTSRAEEWLNLLLEYQKHMET 342
            ALK  L           T +  K   L   W      ++   +A +WLN +    K  E 
Sbjct: 1235 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTEN 1294

Query: 343  FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLK--AELNDIRPKVDSTRDQAANL 400
                 + I++ +   + L+  SE   P Q   + + L     ++++  +   T +     
Sbjct: 1295 IPGGAEEISEVLDSLENLMRHSE-DNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1353

Query: 401  MANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSD-IQKLLEPLEAE 459
            +       +KL+E  I        ++ H I+     I  K+L  + +D +     P EA+
Sbjct: 1354 LHEEAVRRQKLLEQSIQSAQETEKSL-HLIQESLTFID-KQLAAYIADKVDAAQMPQEAQ 1411

Query: 460  IQQGVNLKEEDFNKDMNEDNEGTVK----------------------ELLQRGDNLQQRI 497
              Q      E   ++M + N+G                          L Q+  N +QR+
Sbjct: 1412 KIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRL 1471

Query: 498  TDERK-REEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKC-LDDI 555
             + +   +E+K+    L+TK    + ++SQ     + +     + K + + ++K     +
Sbjct: 1472 QESKMILDEVKMHLPALETKSVEQEVVQSQ-LNHCVNLYKSLSEVKSEVEMVIKTGRQIV 1530

Query: 556  EKKLASLPEPRDER-------------KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAM 602
            +KK    P+  DER             K+ E  ++L+K  +    +R++   L+E  AA 
Sbjct: 1531 QKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAAT 1590

Query: 603  AVE----------PTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTE------ 646
             +E          P+ +     W +   K  + ++++   I  V E    V+ +      
Sbjct: 1591 DMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVE 1650

Query: 647  ---------------------DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 685
                                 ++ LE      T+   + H+++ +++ + LL+  +    
Sbjct: 1651 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1710

Query: 686  DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 745
                  ++E+ LK +K  L     ++D    +    + +     R  ++  +S+L+ ++ 
Sbjct: 1711 Q-----QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFA 1765

Query: 746  KVNKMYKDRQGRFDRSVEKWRRFHYDI-KIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL 804
             ++  ++ + G+    +++  +F+ DI K+      E +Q +          + K + + 
Sbjct: 1766 AIS--HRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGV----------NLKEEDFN 1813

Query: 805  KEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKK 863
            K++ +D  G  + +++  +   + I  +  + +  I Q+ L + +   +++    S R+K
Sbjct: 1814 KDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL---RSQRRK 1870

Query: 864  RLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLR 922
            +  E  +   +++R  ++ +  L++ +  +AS+P EP  E+++KE   +++   EEL   
Sbjct: 1871 KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP-EPRDERKIKEIDRELQKKKEELNAV 1929

Query: 923  QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 982
            +   + L+E G  + V            E    Q + +W ++     + +    AQI  +
Sbjct: 1930 RRQAEGLSEDGAAMAV------------EPTQIQLSKRWREIESKFAQFRRLNFAQIHTV 1977

Query: 983  GQ--LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEE 1040
             +  +    ED+  +++++     P     EI +    +   +V++   A      D E+
Sbjct: 1978 REETMMVMTEDMPLEISYV-----PSTYLTEITHV--SQALLEVEQLLNAPDLCAKDFED 2030

Query: 1041 ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQT 1100
            +  + + L   K + Q    +++ + S+  A  +                    A+P + 
Sbjct: 2031 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQ-------------------SATPVER 2071

Query: 1101 VTLVTQPVVTKETAISKLEMPSSLMLEV--PALADFNRA---WTE-------LTDWLSLL 1148
            V L        + A+S+L+     + ++       F+R+   W            WL+  
Sbjct: 2072 VKL--------QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEA 2123

Query: 1149 DQVIKSQRVMVGDLEDINEMIIKQKATMQD-LEQRRPQLEELITAAQNLKNKTSNQEART 1207
            +Q ++  ++         +  +K+   +QD + QR+  +  L    + +  ++S  +A +
Sbjct: 2124 EQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDA-S 2179

Query: 1208 IITDRIERIQNQWDEVQEHLQNRRQQ-------LNEMLKDSTQWLEAKEEAEQVLGQARA 1260
            I+ +++  +  +W EV + L +R+++       L+E  +D  +++   EEA+ +   A  
Sbjct: 2180 ILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI---ASI 2236

Query: 1261 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL--RDYSADDTRKV 1318
             LE  KE       +++K+ + K L ++L   Q  +   N+    +L     S ++  K+
Sbjct: 2237 PLEPGKE-----QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2291

Query: 1319 HMITENINASWRSIHKRVSEREAALE-------ETHRLLQQFPLDLEKFLAWL------- 1364
                +  N  W  + + + E++  +E       +  + L+     L   L WL       
Sbjct: 2292 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2351

Query: 1365 ----------------TEAETTA---NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIE 1405
                            TE    A   +V +  ++ + L ++    + + ++ +DL  E +
Sbjct: 2352 EIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWK 2411

Query: 1406 AHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQ 1465
            A   +   L      +   L     +      L        E     L + S L      
Sbjct: 2412 AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA 2471

Query: 1466 WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTL 1525
                + +  EL  WL L D  +  Q  + GD   + +     +A  ++L+ + P      
Sbjct: 2472 LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP------ 2525

Query: 1526 ETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQ 1585
                          LE+L    + L  +   Q    ++  + E +  +W+++  H  + +
Sbjct: 2526 -------------QLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRR 2572

Query: 1586 RKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIA 1645
            ++++E L+   +  EA +E +  L QA     SW+  G   +D++Q  + + K L  ++ 
Sbjct: 2573 QQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE-GPYTVDAIQKKITETKQLAKDLR 2631

Query: 1646 PLKENVSHVNDLARQLTTLGIQLSPYNLS-------TLEDLNTRWKLLQVAVEDRVRQLH 1698
              + NV   NDLA +L      L  Y+           E++N  W+ +   V +R   L 
Sbjct: 2632 QWQTNVDVANDLALKL------LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2685

Query: 1699 EAHR 1702
            E HR
Sbjct: 2686 ETHR 2689



 Score =  107 bits (266), Expect = 2e-22
 Identities = 244/1327 (18%), Positives = 522/1327 (39%), Gaps = 212/1327 (15%)

Query: 304  KETLVEDKLSLLNSNWIAV-TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 362
            +ET V+++++LLNS W  +  +  E+  NL   ++  M+  +Q +  +  W+ + +    
Sbjct: 416  EETEVQEQMNLLNSRWECLRVASMEKQSNL---HRVLMDLQNQKLKELNDWLTKTEERTR 472

Query: 363  ESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 415
            + E++      + LKR       L+ +L   + +V+S       +  + GDH    +E Q
Sbjct: 473  KMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ 532

Query: 416  ISELNHRFAAISHRIKTGKASIPLKELE---QFNSDIQKLLEPLEAEIQQGVNLKEEDFN 472
            +  L  R+A I     T    + L+++    Q  ++ Q L     +E +  VN       
Sbjct: 533  LKVLGDRWANICRW--TEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 590

Query: 473  KDMNEDNEGTVKELLQRGDNLQQRITDERKREEI----KIKQQLLQTKHNALKDLRSQRR 528
            KD NE      K  + + D        E+K++ +     +KQ LL T  N          
Sbjct: 591  KDQNEMLSSLQKLAVLKADL-------EKKKQSMGKLYSLKQDLLSTLKN---------- 633

Query: 529  KKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 588
            K   + +  W       D+  +C D++ +KL        E+   +I + +   +  L   
Sbjct: 634  KSVTQKTEAWL------DNFARCWDNLVQKL--------EKSTAQISQAVTTTQPSLTQT 679

Query: 589  RRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDM 648
                     +         QI +     E+     Q +R    QI TV  E    +  D 
Sbjct: 680  TVM------ETVTTVTTREQILVKHAQEELPPPPPQKKR----QI-TVDSEIRKRLDVD- 727

Query: 649  PLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSS 708
                          IT +   +   E +L +P+        +F++E +  ++K+ +    
Sbjct: 728  --------------ITELHSWITRSEAVLQSPEFA------IFRKEGNFSDLKEKVNA-- 765

Query: 709  GRIDIIHSKKTAALQSATP-------------VERVKLQEALSQLDFQWEKVNKMYKDRQ 755
              I+   ++K   LQ A+              V    +++A  QL+ +W +  ++  +R 
Sbjct: 766  --IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERL 823

Query: 756  GRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW---------EHAKYKWYLKE 806
                     W  +  +I  F   L + EQ    T   ENW         E    K  LK 
Sbjct: 824  N--------WLEYQNNIIAFYNQLQQLEQM---TTTAENWLKIQPTTPSEPTAIKSQLKI 872

Query: 807  LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASI-LQEKLGSLNLRWQEVCKQLSDRKKRL 865
             +D + +   +   +     + I    K    + L     +    +++V   +  R+K L
Sbjct: 873  CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKEL 932

Query: 866  EEQKNILS--EFQRDLNEFVLWLEEADNIASIP-LEPGKEQQLKEKLEQVKLLVEELPLR 922
            +   + L    +Q  ++    W+++++   SIP L     + ++++L +++ L   L  +
Sbjct: 933  QTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQ 992

Query: 923  QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 982
            Q  L  L+ T   +   AP   E   K +++ ++   +W K+S  L E   ++E Q+  L
Sbjct: 993  QSGLYYLSTTVKEMSKKAP--SEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKL 1050

Query: 983  GQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 1039
             +++  ++ L++ +  + ++L    P     EI  +  ++    V +    +Q  QP + 
Sbjct: 1051 RKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD----IQTIQPSLN 1106

Query: 1040 EILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 1097
             +   GQ +  E        ++ +L++L+++W   + + Q++ A++  L  GL       
Sbjct: 1107 SVNEGGQKIKNEAEPEFASRLETELKELNTQW---DHMCQQVYARKEALKGGLE------ 1157

Query: 1098 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 1157
             +TV+L                                +  +E+ +W++  ++    +  
Sbjct: 1158 -KTVSL-------------------------------QKDLSEMHEWMTQAEEEYLERDF 1185

Query: 1158 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 1217
                 +++ + + + K   ++ +Q+  +++ L+T + N     +   A+  +   +E + 
Sbjct: 1186 EYKTPDELQKAVEEMKRAKEEAQQKEAKVK-LLTESVNSVIAQAPPVAQEALKKELETLT 1244

Query: 1218 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 1277
              +  +   L  + + L E+     + L   E+A + L +   KL++ +  P   + I +
Sbjct: 1245 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1304

Query: 1278 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 1337
             +   + L   +R  + N +    LA  L      D+   ++   E  N+ WR +H+   
Sbjct: 1305 VLDSLENL---MRHSEDNPNQIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAV 1359

Query: 1338 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1397
             R+  LE++ +  Q    + EK L  + E+ T  +      +    + D     ++ ++ 
Sbjct: 1360 RRQKLLEQSIQSAQ----ETEKSLHLIQESLTFID-----KQLAAYIADKVDAAQMPQEA 1410

Query: 1398 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1457
            Q +Q ++ +H      + +++Q    +        + Q++L +++ K+  L +K  N   
Sbjct: 1411 QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQ 1469

Query: 1458 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1517
             L+ S        + L E+ + L   + +   Q  +      +    +++++        
Sbjct: 1470 RLQESK-------MILDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEVKSEV 1519

Query: 1518 EPVIMSTLETVRIFLTEQPLEGLE-----KLYQEPRELPPEERAQNVTRLL---RKQAEE 1569
            E VI +  + V+   TE P E  E     KL+         ER Q + + L   RK  +E
Sbjct: 1520 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1579

Query: 1570 VN--TEW 1574
            +N  TEW
Sbjct: 1580 MNVLTEW 1586



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 190/965 (19%), Positives = 382/965 (39%), Gaps = 98/965 (10%)

Query: 778  WLTEAEQFLR-KTQIPENWEHAKYKWYLKE--LQDGIGQRQTVVRTLNATGEEIIQQS-- 832
            WL  AE  L+ + +I  + E  K +++  E  + D +   Q  V  +   G ++I     
Sbjct: 354  WLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD-LTAHQGRVGNILQLGSKLIGTGKL 412

Query: 833  SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWL----EE 888
            S+ + + +QE++  LN RW+  C +++  +K+    + ++    + L E   WL    E 
Sbjct: 413  SEDEETEVQEQMNLLNSRWE--CLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEER 470

Query: 889  ADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD 948
               +   PL P  E  LK +++Q K+L E+L   Q  +  L  T   V+V          
Sbjct: 471  TRKMEEEPLGPDLED-LKRQVQQHKVLQEDLEQEQVRVNSL--THMVVVVDESSGDHATA 527

Query: 949  KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 1008
             LE +LK    +W  + R   ++   ++        +  K + L E+      WLS    
Sbjct: 528  ALEEQLKVLGDRWANICRWTEDRWVLLQ-------DILLKWQRLTEEQCLFSAWLS---E 577

Query: 1009 QLEIYNQPNQEGPFDVQETEIAVQA----------KQPDVEEILSKGQHLY---KEKPAT 1055
            + +  N+ +  G  D  E   ++Q           K+  + ++ S  Q L    K K  T
Sbjct: 578  KEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT 637

Query: 1056 QPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI 1115
            Q  +  L++ +  W   + L+Q+L      ++  +TT   S TQT  + T   VT    I
Sbjct: 638  QKTEAWLDNFARCW---DNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQI 694

Query: 1116 ----SKLEMPS-------SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMV----G 1160
                ++ E+P         + ++       +   TEL  W++  + V++S    +    G
Sbjct: 695  LVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEG 754

Query: 1161 DLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART-IITDRIERIQNQ 1219
            +  D+ E   K  A  ++  ++  +L++   +AQ L  +  N+      I    E++ ++
Sbjct: 755  NFSDLKE---KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 811

Query: 1220 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 1279
            W E  + L  R   L E   +   +    ++ EQ+   A   L+     P    AI+ ++
Sbjct: 812  WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 870

Query: 1280 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 1339
               K     L   Q  ++     ++ L              +       ++ +   V  R
Sbjct: 871  KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA--FTNHFKQVFSDVQAR 928

Query: 1340 EAALEETHRLL--QQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1397
            E  L+     L   ++   +     W+ ++ET  ++ Q +     ++E   G      + 
Sbjct: 929  EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG------EL 982

Query: 1398 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1457
            Q LQ  ++      + L    +++ +    S+ +   Q   + +  +W +L  + +    
Sbjct: 983  QALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1041

Query: 1458 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1517
             LE   ++ +++   +Q L  W+   D  L  + P  GD   ++KQ    R    +++T 
Sbjct: 1042 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 1101

Query: 1518 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 1577
            +P + S              EG +K+     E  PE  ++     L  + +E+NT+W+ +
Sbjct: 1102 QPSLNSV------------NEGGQKI---KNEAEPEFASR-----LETELKELNTQWDHM 1141

Query: 1578 NLHSADWQRKIDETLERLQELQEATDELDLKLRQA--EVIKGSWQPVGDLLIDSLQDHLE 1635
                   +  +   LE+   LQ+   E+   + QA  E ++  ++       D LQ  +E
Sbjct: 1142 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP---DELQKAVE 1198

Query: 1636 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRV 1694
            ++K  + E    +  V  + +    +      ++   L   LE L T ++ L   +  + 
Sbjct: 1199 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1258

Query: 1695 RQLHE 1699
            + L E
Sbjct: 1259 KTLEE 1263



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 76/369 (20%), Positives = 140/369 (37%), Gaps = 28/369 (7%)

Query: 1098 TQTVTLVTQPVVTKETAISKLEMP------SSLMLEVPALADFNRAWTELTDWLSLLDQV 1151
            TQ   + T            LE P      SSLM     L  +  A  E+  WL   +  
Sbjct: 302  TQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDT 361

Query: 1152 IKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNL--------KNKTSNQ 1203
            +++Q  +  D+E + +     +  M DL   + ++  ++     L          +T  Q
Sbjct: 362  LQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQ 421

Query: 1204 EARTIITDRIERIQNQWDEVQEHLQNRRQQL-NEMLKDSTQWLEAKEEAEQVLGQARAKL 1262
            E   ++  R E ++    E Q +L      L N+ LK+   WL   EE  +       K+
Sbjct: 422  EQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTR-------KM 474

Query: 1263 ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMIT 1322
            E    GP  ++ +++++ + K L +DL Q Q  V+    + + +        T  +    
Sbjct: 475  EEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQL 533

Query: 1323 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1382
            + +   W +I +   +R   L++     Q+   +   F AWL+E E   N +     K  
Sbjct: 534  KVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFK-- 591

Query: 1383 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1442
               D   +   +++   L+ ++E        L    Q +L +L+        +  LDN  
Sbjct: 592  ---DQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 648

Query: 1443 FKWSELRKK 1451
              W  L +K
Sbjct: 649  RCWDNLVQK 657



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)

Query: 1405 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 1459
            E H  ++H +  + Q  +   +G +     + R  +  +  +     S   RS     HL
Sbjct: 263  EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 322

Query: 1460 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 1507
            EA  D+              R   +L+E+L WL   +D L  Q  I  D   V+ Q   H
Sbjct: 323  EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 382

Query: 1508 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 1567
              +  +L   +  + + L+          L G  KL ++      EE        +++Q 
Sbjct: 383  EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 424

Query: 1568 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 1622
              +N+ WE L + S + Q  +   L     ++L+EL +   + + + R+ E      +P+
Sbjct: 425  NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 479

Query: 1623 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 1678
            G  L D L+  +++ K L+ +   L++    VN L   +  +      +  + LE+    
Sbjct: 480  GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 535

Query: 1679 LNTRWKLLQVAVEDR 1693
            L  RW  +    EDR
Sbjct: 536  LGDRWANICRWTEDR 550


>gi|5032293 dystrophin Dp140 isoform [Homo sapiens]
          Length = 1225

 Score = 2452 bits (6355), Expect = 0.0
 Identities = 1225/1225 (100%), Positives = 1225/1225 (100%)

Query: 1120 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 1179
            MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1    MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60

Query: 1180 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 1239
            EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61   EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120

Query: 1240 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 1299
            DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121  DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180

Query: 1300 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 1359
            NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181  NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240

Query: 1360 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 1419
            FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241  FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300

Query: 1420 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 1479
            KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301  KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360

Query: 1480 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 1539
            LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361  LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420

Query: 1540 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 1599
            LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421  LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480

Query: 1600 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 1659
            EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481  EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540

Query: 1660 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 1719
            QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541  QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600

Query: 1720 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 1779
            WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601  WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660

Query: 1780 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 1839
            LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661  LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720

Query: 1840 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 1899
            WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721  WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780

Query: 1900 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 1959
            SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781  SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840

Query: 1960 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 2019
            VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841  VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900

Query: 2020 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 2079
            TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS
Sbjct: 901  TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 960

Query: 2080 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 2139
            APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
Sbjct: 961  APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 1020

Query: 2140 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 2199
            QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
Sbjct: 1021 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 1080

Query: 2200 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 2259
            SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
Sbjct: 1081 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 1140

Query: 2260 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 2319
            QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
Sbjct: 1141 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 1200

Query: 2320 EQLNNSFPSSRGRNTPGKPMREDTM 2344
            EQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 1201 EQLNNSFPSSRGRNTPGKPMREDTM 1225



 Score =  100 bits (249), Expect = 2e-20
 Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)

Query: 664  THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 722
            T ++  L  ++Q++ +  +   D ED+ +     K     L+Q   +++ +I + +    
Sbjct: 20   TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79

Query: 723  QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 780
            +++    R  + + + ++  QW++V +  ++R+ + +            +K   QWL   
Sbjct: 80   KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129

Query: 781  -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 830
             EAEQ L + +   E+W+   Y            K+L   + Q QT V   N    ++++
Sbjct: 130  EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189

Query: 831  QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 890
              S  D   +     ++N  W+ + K++S+R+  LEE   +L +F  DL +F+ WL EA+
Sbjct: 190  DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249

Query: 891  NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 943
              A++  +  ++++L E  + VK L+++    QG       +   L+E    +L S   S
Sbjct: 250  TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309

Query: 944  PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 1003
             ++   L+ +L   N +W ++ +     +  +EA      +L   L++       LL+WL
Sbjct: 310  -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361

Query: 1004 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 1063
                   E+  Q    G F       AVQ KQ DV     +   L  ++P        + 
Sbjct: 362  Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410

Query: 1064 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 1120
               +E   + + +L QE R   P+             Q VT L+ +      T   KL +
Sbjct: 411  IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460

Query: 1121 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 1174
             S+    ++    +  +   E TD L L     +VIK     VGDL  + + + + K KA
Sbjct: 461  HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520

Query: 1175 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 1234
               ++   +  +  +   A+ L           + T  +E +  +W  +Q  +++R +QL
Sbjct: 521  LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578

Query: 1235 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 1289
            +E  +D    S  +L    +       +  K+  +      T      K+TE  Q   DL
Sbjct: 579  HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638

Query: 1290 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 1340
               + +          +   L L LL   +A D    H + +N        I   ++   
Sbjct: 639  NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698

Query: 1341 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 1395
              LE+ H  L   PL ++  L WL     T       T + R+L    G+  L K
Sbjct: 699  DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 128/599 (21%), Positives = 244/599 (40%), Gaps = 58/599 (9%)

Query: 242 LTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 301
           LT+WL+  D  +  +  + G   +++  +   KAT +++E+++  L+ +    + LK   
Sbjct: 22  LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81

Query: 302 GKKE--TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADT 359
             +E  T++ D++  + + W  V    +     L E  K    + +  +   + + QA  
Sbjct: 82  SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141

Query: 360 LLDESEKKKP------QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVE 413
            L ES K+ P      Q+K    K+L  +L   +  VD   D A  L+ +      + V 
Sbjct: 142 KL-ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 200

Query: 414 PQISELNHRFAAISHRIKTGKASI--PLKELEQFNSDIQKLLEPL-EAEIQQGVNLKEED 470
                +N  + +I  R+   +A++    + L+QF  D++K L  L EAE    V L++  
Sbjct: 201 MITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV-LQDAT 259

Query: 471 FNKDMNEDNEGTVKELLQRGDNLQQRI---------TDERKREEIKIKQ-----QLLQTK 516
             + + ED++G VKEL+++  +LQ  I          DE  ++ ++  +      LLQ +
Sbjct: 260 RKERLLEDSKG-VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR 318

Query: 517 HNALKDLRSQRRKKALEI-------SHQWYQYKRQADDLLKCLDDIEKKLA-SLPEPRDE 568
            + +    S+ RKK+L I       S QW +      +LL  L   + +L+   P   D 
Sbjct: 319 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDF 378

Query: 569 RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 628
             +++ +   +  K EL           E       E     L K ++E      + R  
Sbjct: 379 PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQ 438

Query: 629 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 688
           N  ++  +R++   V TE   L +    + +  +I    + L E+++  +  DL  +  E
Sbjct: 439 NVTRL--LRKQAEEVNTEWEKLNLH--SADWQRKIDETLERLQELQEATDELDLKLRQAE 494

Query: 689 DLFKQEESLKNIK-DSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQ---- 743
            +    + + ++  DSLQ    ++  +  +     ++ + V    L   L+ L  Q    
Sbjct: 495 VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVN--DLARQLTTLGIQLSPY 552

Query: 744 ----WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHA 798
                E +N  +K  Q   +  V +    H D          A Q    T +   WE A
Sbjct: 553 NLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRD-------FGPASQHFLSTSVQGPWERA 604



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 87/493 (17%), Positives = 199/493 (40%), Gaps = 64/493 (12%)

Query: 50  KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM-------KKHNQGKEAA------ 96
           K     + D  D  +M  + +    DL      LEE+       K     +EA       
Sbjct: 34  KSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDR 93

Query: 97  -QRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 154
            +R+ +Q D  Q+ LQ+   +   + +    + +  +E++ +L + +  L + +      
Sbjct: 94  IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTV 153

Query: 155 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 214
           + +Q ++     L K L + ++ V++      ++++    ++ +++      +   +  +
Sbjct: 154 DAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSI 213

Query: 215 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG- 273
             +V+ER+  LE+  +L ++   ++     WL  T+ E T     +        E + G 
Sbjct: 214 HKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGV 271

Query: 274 KATQKEIEKQKVHLKSITEV--------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTS 324
           K   K+ +  +  +++ T+V         + L+++ G  +  L++ +L  +N  W  +  
Sbjct: 272 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRK 331

Query: 325 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP--------QQKEDVL 376
           ++    + L       +    ++  +  W+   D   DE  ++ P        Q++ DV 
Sbjct: 332 KSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVH 388

Query: 377 KRLKAELNDIRPKVDSTRDQAANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGK 434
           +  K EL    P + ST +     +  +  +   KL  EP+      R   ++  ++   
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--- 445

Query: 435 ASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ 494
                K+ E+ N++ +KL            NL   D+ + ++E  E  ++EL +  D L 
Sbjct: 446 -----KQAEEVNTEWEKL------------NLHSADWQRKIDETLE-RLQELQEATDELD 487

Query: 495 QRITDERKREEIK 507
            ++   R+ E IK
Sbjct: 488 LKL---RQAEVIK 497



 Score = 35.0 bits (79), Expect = 0.87
 Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)

Query: 926  LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 981
            L ++  + G  L  + ISP E    E+ L Q   Q +     L + +      I  + ++
Sbjct: 984  LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 1042

Query: 982  LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 1041
             G+LE+ L DLEE+  +L      ++ Q E         P ++  T      + P   E+
Sbjct: 1043 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 1098

Query: 1042 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 1098
            +++ + L + K   +   + LED + + ++ ++RL Q L   Q +     TT+ +  T
Sbjct: 1099 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 1156


>gi|5032309 dystrophin Dp140b isoform [Homo sapiens]
          Length = 1243

 Score = 2427 bits (6289), Expect = 0.0
 Identities = 1213/1214 (99%), Positives = 1213/1214 (99%)

Query: 1120 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 1179
            MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1    MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60

Query: 1180 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 1239
            EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61   EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120

Query: 1240 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 1299
            DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121  DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180

Query: 1300 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 1359
            NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181  NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240

Query: 1360 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 1419
            FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241  FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300

Query: 1420 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 1479
            KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301  KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360

Query: 1480 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 1539
            LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361  LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420

Query: 1540 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 1599
            LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421  LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480

Query: 1600 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 1659
            EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481  EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540

Query: 1660 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 1719
            QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541  QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600

Query: 1720 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 1779
            WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601  WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660

Query: 1780 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 1839
            LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661  LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720

Query: 1840 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 1899
            WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721  WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780

Query: 1900 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 1959
            SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781  SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840

Query: 1960 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 2019
            VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841  VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900

Query: 2020 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 2079
            TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS
Sbjct: 901  TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 960

Query: 2080 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 2139
            APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
Sbjct: 961  APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 1020

Query: 2140 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 2199
            QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
Sbjct: 1021 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 1080

Query: 2200 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 2259
            SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
Sbjct: 1081 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 1140

Query: 2260 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 2319
            QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
Sbjct: 1141 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 1200

Query: 2320 EQLNNSFPSSRGRN 2333
            EQLNNSFPSSRG N
Sbjct: 1201 EQLNNSFPSSRGHN 1214



 Score =  100 bits (249), Expect = 2e-20
 Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)

Query: 664  THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 722
            T ++  L  ++Q++ +  +   D ED+ +     K     L+Q   +++ +I + +    
Sbjct: 20   TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79

Query: 723  QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 780
            +++    R  + + + ++  QW++V +  ++R+ + +            +K   QWL   
Sbjct: 80   KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129

Query: 781  -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 830
             EAEQ L + +   E+W+   Y            K+L   + Q QT V   N    ++++
Sbjct: 130  EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189

Query: 831  QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 890
              S  D   +     ++N  W+ + K++S+R+  LEE   +L +F  DL +F+ WL EA+
Sbjct: 190  DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249

Query: 891  NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 943
              A++  +  ++++L E  + VK L+++    QG       +   L+E    +L S   S
Sbjct: 250  TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309

Query: 944  PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 1003
             ++   L+ +L   N +W ++ +     +  +EA      +L   L++       LL+WL
Sbjct: 310  -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361

Query: 1004 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 1063
                   E+  Q    G F       AVQ KQ DV     +   L  ++P        + 
Sbjct: 362  Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410

Query: 1064 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 1120
               +E   + + +L QE R   P+             Q VT L+ +      T   KL +
Sbjct: 411  IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460

Query: 1121 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 1174
             S+    ++    +  +   E TD L L     +VIK     VGDL  + + + + K KA
Sbjct: 461  HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520

Query: 1175 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 1234
               ++   +  +  +   A+ L           + T  +E +  +W  +Q  +++R +QL
Sbjct: 521  LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578

Query: 1235 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 1289
            +E  +D    S  +L    +       +  K+  +      T      K+TE  Q   DL
Sbjct: 579  HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638

Query: 1290 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 1340
               + +          +   L L LL   +A D    H + +N        I   ++   
Sbjct: 639  NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698

Query: 1341 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 1395
              LE+ H  L   PL ++  L WL     T       T + R+L    G+  L K
Sbjct: 699  DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 128/599 (21%), Positives = 244/599 (40%), Gaps = 58/599 (9%)

Query: 242 LTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 301
           LT+WL+  D  +  +  + G   +++  +   KAT +++E+++  L+ +    + LK   
Sbjct: 22  LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81

Query: 302 GKKE--TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADT 359
             +E  T++ D++  + + W  V    +     L E  K    + +  +   + + QA  
Sbjct: 82  SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141

Query: 360 LLDESEKKKP------QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVE 413
            L ES K+ P      Q+K    K+L  +L   +  VD   D A  L+ +      + V 
Sbjct: 142 KL-ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 200

Query: 414 PQISELNHRFAAISHRIKTGKASI--PLKELEQFNSDIQKLLEPL-EAEIQQGVNLKEED 470
                +N  + +I  R+   +A++    + L+QF  D++K L  L EAE    V L++  
Sbjct: 201 MITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV-LQDAT 259

Query: 471 FNKDMNEDNEGTVKELLQRGDNLQQRI---------TDERKREEIKIKQ-----QLLQTK 516
             + + ED++G VKEL+++  +LQ  I          DE  ++ ++  +      LLQ +
Sbjct: 260 RKERLLEDSKG-VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR 318

Query: 517 HNALKDLRSQRRKKALEI-------SHQWYQYKRQADDLLKCLDDIEKKLA-SLPEPRDE 568
            + +    S+ RKK+L I       S QW +      +LL  L   + +L+   P   D 
Sbjct: 319 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDF 378

Query: 569 RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 628
             +++ +   +  K EL           E       E     L K ++E      + R  
Sbjct: 379 PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQ 438

Query: 629 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 688
           N  ++  +R++   V TE   L +    + +  +I    + L E+++  +  DL  +  E
Sbjct: 439 NVTRL--LRKQAEEVNTEWEKLNLH--SADWQRKIDETLERLQELQEATDELDLKLRQAE 494

Query: 689 DLFKQEESLKNIK-DSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQ---- 743
            +    + + ++  DSLQ    ++  +  +     ++ + V    L   L+ L  Q    
Sbjct: 495 VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVN--DLARQLTTLGIQLSPY 552

Query: 744 ----WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHA 798
                E +N  +K  Q   +  V +    H D          A Q    T +   WE A
Sbjct: 553 NLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRD-------FGPASQHFLSTSVQGPWERA 604



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 87/493 (17%), Positives = 199/493 (40%), Gaps = 64/493 (12%)

Query: 50  KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM-------KKHNQGKEAA------ 96
           K     + D  D  +M  + +    DL      LEE+       K     +EA       
Sbjct: 34  KSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDR 93

Query: 97  -QRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 154
            +R+ +Q D  Q+ LQ+   +   + +    + +  +E++ +L + +  L + +      
Sbjct: 94  IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTV 153

Query: 155 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 214
           + +Q ++     L K L + ++ V++      ++++    ++ +++      +   +  +
Sbjct: 154 DAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSI 213

Query: 215 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG- 273
             +V+ER+  LE+  +L ++   ++     WL  T+ E T     +        E + G 
Sbjct: 214 HKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGV 271

Query: 274 KATQKEIEKQKVHLKSITEV--------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTS 324
           K   K+ +  +  +++ T+V         + L+++ G  +  L++ +L  +N  W  +  
Sbjct: 272 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRK 331

Query: 325 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP--------QQKEDVL 376
           ++    + L       +    ++  +  W+   D   DE  ++ P        Q++ DV 
Sbjct: 332 KSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVH 388

Query: 377 KRLKAELNDIRPKVDSTRDQAANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGK 434
           +  K EL    P + ST +     +  +  +   KL  EP+      R   ++  ++   
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--- 445

Query: 435 ASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ 494
                K+ E+ N++ +KL            NL   D+ + ++E  E  ++EL +  D L 
Sbjct: 446 -----KQAEEVNTEWEKL------------NLHSADWQRKIDETLE-RLQELQEATDELD 487

Query: 495 QRITDERKREEIK 507
            ++   R+ E IK
Sbjct: 488 LKL---RQAEVIK 497



 Score = 35.0 bits (79), Expect = 0.87
 Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)

Query: 926  LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 981
            L ++  + G  L  + ISP E    E+ L Q   Q +     L + +      I  + ++
Sbjct: 984  LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 1042

Query: 982  LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 1041
             G+LE+ L DLEE+  +L      ++ Q E         P ++  T      + P   E+
Sbjct: 1043 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 1098

Query: 1042 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 1098
            +++ + L + K   +   + LED + + ++ ++RL Q L   Q +     TT+ +  T
Sbjct: 1099 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 1156


>gi|5032311 dystrophin Dp140ab isoform [Homo sapiens]
          Length = 1230

 Score = 2390 bits (6193), Expect = 0.0
 Identities = 1200/1214 (98%), Positives = 1200/1214 (98%), Gaps = 13/1214 (1%)

Query: 1120 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 1179
            MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1    MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60

Query: 1180 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 1239
            EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61   EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120

Query: 1240 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 1299
            DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121  DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180

Query: 1300 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 1359
            NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181  NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240

Query: 1360 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 1419
            FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241  FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300

Query: 1420 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 1479
            KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301  KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360

Query: 1480 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 1539
            LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361  LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420

Query: 1540 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 1599
            LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421  LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480

Query: 1600 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 1659
            EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481  EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540

Query: 1660 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 1719
            QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541  QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600

Query: 1720 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 1779
            WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601  WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660

Query: 1780 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 1839
            LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661  LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720

Query: 1840 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 1899
            WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721  WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780

Query: 1900 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 1959
            SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781  SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840

Query: 1960 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 2019
            VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841  VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900

Query: 2020 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 2079
            TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET            
Sbjct: 901  TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET------------ 948

Query: 2080 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 2139
             PASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
Sbjct: 949  -PASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 1007

Query: 2140 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 2199
            QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
Sbjct: 1008 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 1067

Query: 2200 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 2259
            SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
Sbjct: 1068 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 1127

Query: 2260 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 2319
            QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
Sbjct: 1128 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 1187

Query: 2320 EQLNNSFPSSRGRN 2333
            EQLNNSFPSSRG N
Sbjct: 1188 EQLNNSFPSSRGHN 1201



 Score =  100 bits (249), Expect = 2e-20
 Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)

Query: 664  THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 722
            T ++  L  ++Q++ +  +   D ED+ +     K     L+Q   +++ +I + +    
Sbjct: 20   TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79

Query: 723  QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 780
            +++    R  + + + ++  QW++V +  ++R+ + +            +K   QWL   
Sbjct: 80   KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129

Query: 781  -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 830
             EAEQ L + +   E+W+   Y            K+L   + Q QT V   N    ++++
Sbjct: 130  EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189

Query: 831  QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 890
              S  D   +     ++N  W+ + K++S+R+  LEE   +L +F  DL +F+ WL EA+
Sbjct: 190  DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249

Query: 891  NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 943
              A++  +  ++++L E  + VK L+++    QG       +   L+E    +L S   S
Sbjct: 250  TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309

Query: 944  PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 1003
             ++   L+ +L   N +W ++ +     +  +EA      +L   L++       LL+WL
Sbjct: 310  -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361

Query: 1004 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 1063
                   E+  Q    G F       AVQ KQ DV     +   L  ++P        + 
Sbjct: 362  Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410

Query: 1064 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 1120
               +E   + + +L QE R   P+             Q VT L+ +      T   KL +
Sbjct: 411  IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460

Query: 1121 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 1174
             S+    ++    +  +   E TD L L     +VIK     VGDL  + + + + K KA
Sbjct: 461  HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520

Query: 1175 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 1234
               ++   +  +  +   A+ L           + T  +E +  +W  +Q  +++R +QL
Sbjct: 521  LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578

Query: 1235 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 1289
            +E  +D    S  +L    +       +  K+  +      T      K+TE  Q   DL
Sbjct: 579  HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638

Query: 1290 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 1340
               + +          +   L L LL   +A D    H + +N        I   ++   
Sbjct: 639  NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698

Query: 1341 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 1395
              LE+ H  L   PL ++  L WL     T       T + R+L    G+  L K
Sbjct: 699  DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 128/599 (21%), Positives = 244/599 (40%), Gaps = 58/599 (9%)

Query: 242 LTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 301
           LT+WL+  D  +  +  + G   +++  +   KAT +++E+++  L+ +    + LK   
Sbjct: 22  LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81

Query: 302 GKKE--TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADT 359
             +E  T++ D++  + + W  V    +     L E  K    + +  +   + + QA  
Sbjct: 82  SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141

Query: 360 LLDESEKKKP------QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVE 413
            L ES K+ P      Q+K    K+L  +L   +  VD   D A  L+ +      + V 
Sbjct: 142 KL-ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 200

Query: 414 PQISELNHRFAAISHRIKTGKASI--PLKELEQFNSDIQKLLEPL-EAEIQQGVNLKEED 470
                +N  + +I  R+   +A++    + L+QF  D++K L  L EAE    V L++  
Sbjct: 201 MITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV-LQDAT 259

Query: 471 FNKDMNEDNEGTVKELLQRGDNLQQRI---------TDERKREEIKIKQ-----QLLQTK 516
             + + ED++G VKEL+++  +LQ  I          DE  ++ ++  +      LLQ +
Sbjct: 260 RKERLLEDSKG-VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR 318

Query: 517 HNALKDLRSQRRKKALEI-------SHQWYQYKRQADDLLKCLDDIEKKLA-SLPEPRDE 568
            + +    S+ RKK+L I       S QW +      +LL  L   + +L+   P   D 
Sbjct: 319 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDF 378

Query: 569 RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 628
             +++ +   +  K EL           E       E     L K ++E      + R  
Sbjct: 379 PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQ 438

Query: 629 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 688
           N  ++  +R++   V TE   L +    + +  +I    + L E+++  +  DL  +  E
Sbjct: 439 NVTRL--LRKQAEEVNTEWEKLNLH--SADWQRKIDETLERLQELQEATDELDLKLRQAE 494

Query: 689 DLFKQEESLKNIK-DSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQ---- 743
            +    + + ++  DSLQ    ++  +  +     ++ + V    L   L+ L  Q    
Sbjct: 495 VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVN--DLARQLTTLGIQLSPY 552

Query: 744 ----WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHA 798
                E +N  +K  Q   +  V +    H D          A Q    T +   WE A
Sbjct: 553 NLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRD-------FGPASQHFLSTSVQGPWERA 604



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 87/493 (17%), Positives = 199/493 (40%), Gaps = 64/493 (12%)

Query: 50  KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM-------KKHNQGKEAA------ 96
           K     + D  D  +M  + +    DL      LEE+       K     +EA       
Sbjct: 34  KSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDR 93

Query: 97  -QRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 154
            +R+ +Q D  Q+ LQ+   +   + +    + +  +E++ +L + +  L + +      
Sbjct: 94  IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTV 153

Query: 155 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 214
           + +Q ++     L K L + ++ V++      ++++    ++ +++      +   +  +
Sbjct: 154 DAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSI 213

Query: 215 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG- 273
             +V+ER+  LE+  +L ++   ++     WL  T+ E T     +        E + G 
Sbjct: 214 HKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGV 271

Query: 274 KATQKEIEKQKVHLKSITEV--------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTS 324
           K   K+ +  +  +++ T+V         + L+++ G  +  L++ +L  +N  W  +  
Sbjct: 272 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRK 331

Query: 325 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP--------QQKEDVL 376
           ++    + L       +    ++  +  W+   D   DE  ++ P        Q++ DV 
Sbjct: 332 KSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVH 388

Query: 377 KRLKAELNDIRPKVDSTRDQAANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGK 434
           +  K EL    P + ST +     +  +  +   KL  EP+      R   ++  ++   
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--- 445

Query: 435 ASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ 494
                K+ E+ N++ +KL            NL   D+ + ++E  E  ++EL +  D L 
Sbjct: 446 -----KQAEEVNTEWEKL------------NLHSADWQRKIDETLE-RLQELQEATDELD 487

Query: 495 QRITDERKREEIK 507
            ++   R+ E IK
Sbjct: 488 LKL---RQAEVIK 497



 Score = 35.0 bits (79), Expect = 0.87
 Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)

Query: 926  LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 981
            L ++  + G  L  + ISP E    E+ L Q   Q +     L + +      I  + ++
Sbjct: 971  LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 1029

Query: 982  LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 1041
             G+LE+ L DLEE+  +L      ++ Q E         P ++  T      + P   E+
Sbjct: 1030 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 1085

Query: 1042 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 1098
            +++ + L + K   +   + LED + + ++ ++RL Q L   Q +     TT+ +  T
Sbjct: 1086 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 1143


>gi|5032313 dystrophin Dp140bc isoform [Homo sapiens]
          Length = 1133

 Score = 1908 bits (4943), Expect = 0.0
 Identities = 970/1073 (90%), Positives = 988/1073 (92%), Gaps = 52/1073 (4%)

Query: 1120 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 1179
            MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1    MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60

Query: 1180 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 1239
            EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61   EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120

Query: 1240 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 1299
            DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121  DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180

Query: 1300 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 1359
            NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181  NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240

Query: 1360 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 1419
            FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241  FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300

Query: 1420 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 1479
            KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301  KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360

Query: 1480 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 1539
            LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361  LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420

Query: 1540 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 1599
            LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421  LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480

Query: 1600 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 1659
            EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481  EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540

Query: 1660 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 1719
            QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541  QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600

Query: 1720 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 1779
            WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601  WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660

Query: 1780 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 1839
            LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661  LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720

Query: 1840 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 1899
            WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721  WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780

Query: 1900 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 1959
            SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781  SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840

Query: 1960 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 2019
            VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841  VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900

Query: 2020 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 2079
            TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET +          
Sbjct: 901  TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETNL---------- 950

Query: 2080 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 2139
                  Q  +D    + EH               L+   SP E +               
Sbjct: 951  ------QAEYDRLKQQHEHKG-------------LSPLPSPPEMMP-------------- 977

Query: 2140 QDSPLSQPRSPAQILISLES----EERGELERILADLEEENRNLQAEYDRLKQ 2188
                 + P+SP    +  E+    + +G LE  +  LE+ N+ L+++  RL+Q
Sbjct: 978  -----TSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQ 1025



 Score =  306 bits (785), Expect = 1e-82
 Identities = 158/164 (96%), Positives = 159/164 (96%), Gaps = 2/164 (1%)

Query: 2172 LEEENR--NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG 2229
            LE +N   NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
Sbjct: 941  LEGDNMETNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG 1000

Query: 2230 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR 2289
            RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
Sbjct: 1001 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR 1060

Query: 2290 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRN 2333
            VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRG N
Sbjct: 1061 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHN 1104



 Score =  100 bits (249), Expect = 2e-20
 Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)

Query: 664  THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 722
            T ++  L  ++Q++ +  +   D ED+ +     K     L+Q   +++ +I + +    
Sbjct: 20   TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79

Query: 723  QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 780
            +++    R  + + + ++  QW++V +  ++R+ + +            +K   QWL   
Sbjct: 80   KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129

Query: 781  -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 830
             EAEQ L + +   E+W+   Y            K+L   + Q QT V   N    ++++
Sbjct: 130  EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189

Query: 831  QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 890
              S  D   +     ++N  W+ + K++S+R+  LEE   +L +F  DL +F+ WL EA+
Sbjct: 190  DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249

Query: 891  NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 943
              A++  +  ++++L E  + VK L+++    QG       +   L+E    +L S   S
Sbjct: 250  TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309

Query: 944  PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 1003
             ++   L+ +L   N +W ++ +     +  +EA      +L   L++       LL+WL
Sbjct: 310  -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361

Query: 1004 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 1063
                   E+  Q    G F       AVQ KQ DV     +   L  ++P        + 
Sbjct: 362  Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410

Query: 1064 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 1120
               +E   + + +L QE R   P+             Q VT L+ +      T   KL +
Sbjct: 411  IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460

Query: 1121 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 1174
             S+    ++    +  +   E TD L L     +VIK     VGDL  + + + + K KA
Sbjct: 461  HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520

Query: 1175 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 1234
               ++   +  +  +   A+ L           + T  +E +  +W  +Q  +++R +QL
Sbjct: 521  LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578

Query: 1235 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 1289
            +E  +D    S  +L    +       +  K+  +      T      K+TE  Q   DL
Sbjct: 579  HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638

Query: 1290 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 1340
               + +          +   L L LL   +A D    H + +N        I   ++   
Sbjct: 639  NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698

Query: 1341 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 1395
              LE+ H  L   PL ++  L WL     T       T + R+L    G+  L K
Sbjct: 699  DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 128/599 (21%), Positives = 244/599 (40%), Gaps = 58/599 (9%)

Query: 242 LTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 301
           LT+WL+  D  +  +  + G   +++  +   KAT +++E+++  L+ +    + LK   
Sbjct: 22  LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81

Query: 302 GKKE--TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADT 359
             +E  T++ D++  + + W  V    +     L E  K    + +  +   + + QA  
Sbjct: 82  SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141

Query: 360 LLDESEKKKP------QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVE 413
            L ES K+ P      Q+K    K+L  +L   +  VD   D A  L+ +      + V 
Sbjct: 142 KL-ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 200

Query: 414 PQISELNHRFAAISHRIKTGKASI--PLKELEQFNSDIQKLLEPL-EAEIQQGVNLKEED 470
                +N  + +I  R+   +A++    + L+QF  D++K L  L EAE    V L++  
Sbjct: 201 MITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV-LQDAT 259

Query: 471 FNKDMNEDNEGTVKELLQRGDNLQQRI---------TDERKREEIKIKQ-----QLLQTK 516
             + + ED++G VKEL+++  +LQ  I          DE  ++ ++  +      LLQ +
Sbjct: 260 RKERLLEDSKG-VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR 318

Query: 517 HNALKDLRSQRRKKALEI-------SHQWYQYKRQADDLLKCLDDIEKKLA-SLPEPRDE 568
            + +    S+ RKK+L I       S QW +      +LL  L   + +L+   P   D 
Sbjct: 319 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDF 378

Query: 569 RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 628
             +++ +   +  K EL           E       E     L K ++E      + R  
Sbjct: 379 PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQ 438

Query: 629 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 688
           N  ++  +R++   V TE   L +    + +  +I    + L E+++  +  DL  +  E
Sbjct: 439 NVTRL--LRKQAEEVNTEWEKLNLH--SADWQRKIDETLERLQELQEATDELDLKLRQAE 494

Query: 689 DLFKQEESLKNIK-DSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQ---- 743
            +    + + ++  DSLQ    ++  +  +     ++ + V    L   L+ L  Q    
Sbjct: 495 VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVN--DLARQLTTLGIQLSPY 552

Query: 744 ----WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHA 798
                E +N  +K  Q   +  V +    H D          A Q    T +   WE A
Sbjct: 553 NLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRD-------FGPASQHFLSTSVQGPWERA 604



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 87/493 (17%), Positives = 199/493 (40%), Gaps = 64/493 (12%)

Query: 50  KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM-------KKHNQGKEAA------ 96
           K     + D  D  +M  + +    DL      LEE+       K     +EA       
Sbjct: 34  KSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDR 93

Query: 97  -QRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 154
            +R+ +Q D  Q+ LQ+   +   + +    + +  +E++ +L + +  L + +      
Sbjct: 94  IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTV 153

Query: 155 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 214
           + +Q ++     L K L + ++ V++      ++++    ++ +++      +   +  +
Sbjct: 154 DAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSI 213

Query: 215 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG- 273
             +V+ER+  LE+  +L ++   ++     WL  T+ E T     +        E + G 
Sbjct: 214 HKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGV 271

Query: 274 KATQKEIEKQKVHLKSITEV--------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTS 324
           K   K+ +  +  +++ T+V         + L+++ G  +  L++ +L  +N  W  +  
Sbjct: 272 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRK 331

Query: 325 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP--------QQKEDVL 376
           ++    + L       +    ++  +  W+   D   DE  ++ P        Q++ DV 
Sbjct: 332 KSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVH 388

Query: 377 KRLKAELNDIRPKVDSTRDQAANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGK 434
           +  K EL    P + ST +     +  +  +   KL  EP+      R   ++  ++   
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--- 445

Query: 435 ASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ 494
                K+ E+ N++ +KL            NL   D+ + ++E  E  ++EL +  D L 
Sbjct: 446 -----KQAEEVNTEWEKL------------NLHSADWQRKIDETLE-RLQELQEATDELD 487

Query: 495 QRITDERKREEIK 507
            ++   R+ E IK
Sbjct: 488 LKL---RQAEVIK 497


>gi|5032295 dystrophin Dp116 isoform [Homo sapiens]
          Length = 956

 Score = 1907 bits (4939), Expect = 0.0
 Identities = 946/947 (99%), Positives = 947/947 (100%)

Query: 1398 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1457
            +DLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS
Sbjct: 10   KDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 69

Query: 1458 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1517
            HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK
Sbjct: 70   HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 129

Query: 1518 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 1577
            EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL
Sbjct: 130  EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 189

Query: 1578 NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV 1637
            NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV
Sbjct: 190  NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV 249

Query: 1638 KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL 1697
            KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL
Sbjct: 250  KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL 309

Query: 1698 HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 1757
            HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL
Sbjct: 310  HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 369

Query: 1758 NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 1817
            NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY
Sbjct: 370  NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 429

Query: 1818 DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYL 1877
            DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYL
Sbjct: 430  DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYL 489

Query: 1878 FKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEA 1937
            FKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEA
Sbjct: 490  FKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEA 549

Query: 1938 ALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQ 1997
            ALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQ
Sbjct: 550  ALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQ 609

Query: 1998 SCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQ 2057
            SCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQ
Sbjct: 610  SCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQ 669

Query: 2058 TVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDS 2117
            TVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDS
Sbjct: 670  TVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDS 729

Query: 2118 ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENR 2177
            ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENR
Sbjct: 730  ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENR 789

Query: 2178 NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQI 2237
            NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQI
Sbjct: 790  NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQI 849

Query: 2238 LEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSD 2297
            LEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSD
Sbjct: 850  LEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSD 909

Query: 2298 SMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2344
            SMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 910  SMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 956



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 53/235 (22%), Positives = 99/235 (42%), Gaps = 33/235 (14%)

Query: 1140 ELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ-------------- 1185
            EL  WL L D  +  Q  + GD   + +     +A  ++L+ + P               
Sbjct: 87   ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 146

Query: 1186 -----LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKD 1240
                 LE+L    + L  +   Q    ++  + E +  +W+++  H  + +++++E L+ 
Sbjct: 147  QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 206

Query: 1241 STQWLEAKEEAEQVLGQARAKLESWKE-GPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 1299
              +  EA +E +  L QA     SW+  G   +D++Q  + + K L  ++   + NV   
Sbjct: 207  LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 266

Query: 1300 NDLALKL------LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHR 1348
            NDLA +L      L  Y+           E++N  W+ +   V +R   L E HR
Sbjct: 267  NDLARQLTTLGIQLSPYNLSTL-------EDLNTRWKLLQVAVEDRVRQLHEAHR 314



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 79/375 (21%), Positives = 152/375 (40%), Gaps = 34/375 (9%)

Query: 802  WYLKELQDGIGQRQTVVRTLNATGEEIIQQ-SSKTDASILQEKLGSLNLRWQEVCKQLSD 860
            +++K+LQ  I     V   L+   ++I++      DA +LQ +L ++N +W E+ K+  +
Sbjct: 7    YHVKDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 66

Query: 861  RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQV-KLLVEEL 919
             +  LE   +        L E ++WL+  D+  S     G +    +K   V +    EL
Sbjct: 67   IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 126

Query: 920  PLRQGILKQLNETGGPVLVSAPIS-------------PEEQDK-----LENKLKQTNLQW 961
              ++ ++    ET    L   P+              PEE+ +     L  + ++ N +W
Sbjct: 127  KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 186

Query: 962  IKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP 1021
             K++    + Q +I+  ++ L +L++  ++L+ +L    +     +   ++     Q+  
Sbjct: 187  EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHL 246

Query: 1022 FDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK-RKLEDLSSEWK----AVNRLL 1076
              V+     +   + +V  +    + L        P     LEDL++ WK    AV   +
Sbjct: 247  EKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRV 306

Query: 1077 QELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNR 1136
            ++L     D  P      AS     T V  P    E AIS  ++P  +  E       + 
Sbjct: 307  RQLHEAHRDFGP------ASQHFLSTSVQGP---WERAISPNKVPYYINHETQTTCWDHP 357

Query: 1137 AWTELTDWLSLLDQV 1151
              TEL   L+ L+ V
Sbjct: 358  KMTELYQSLADLNNV 372



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 62/314 (19%), Positives = 132/314 (42%), Gaps = 33/314 (10%)

Query: 699 NIKDSLQQSSGRIDIIHSKKTAALQSATPVE----RVKLQEALSQLDFQWEKVNKMYKDR 754
           ++KD   +     D+ H+    + +    +E     V LQ  L  ++F+W ++ K   + 
Sbjct: 8   HVKDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 67

Query: 755 QGRFDRSVEKWRRFHYDIKIFNQWL-TEAEQFLRKTQI--------PENWEHAKYKWYLK 805
           +   + S ++W+R H  ++    WL  + ++  R+  I         +N  H  +K  LK
Sbjct: 68  RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 127

Query: 806 ELQDGIGQRQTVVRTLNATG-----EEIIQ--------QSSKTDASILQEKLGSLNLRWQ 852
             +  I      VR           E++ Q        + ++    +L+++   +N  W+
Sbjct: 128 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 187

Query: 853 EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASI--PLEPGKEQQLKEKLE 910
           ++    +D +++++E    L E Q   +E  L L +A+ I     P+       L++ LE
Sbjct: 188 KLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLE 247

Query: 911 QVKLLVEEL-PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALP 969
           +VK L  E+ PL++ +    +       +   +SP     LE+     N +W  +  A+ 
Sbjct: 248 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED----LNTRWKLLQVAVE 303

Query: 970 EKQGEIEAQIKDLG 983
           ++  ++    +D G
Sbjct: 304 DRVRQLHEAHRDFG 317



 Score = 40.0 bits (92), Expect = 0.027
 Identities = 70/329 (21%), Positives = 138/329 (41%), Gaps = 52/329 (15%)

Query: 1287 KDLR-QWQTNVDVANDL---ALKLLRDYS-ADDTRKVHMITENINASWRSIHKRVSEREA 1341
            KDL+ + + + DV ++L   + K+LR    +DD   +    +N+N  W  + K+     +
Sbjct: 10   KDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 69

Query: 1342 ALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQ 1401
             LE +    ++  L L++ L WL   +       + +R+  +  D   V++     +  +
Sbjct: 70   HLEASSDQWKRLHLSLQELLVWLQLKD------DELSRQAPIGGDFPAVQKQNDVHRAFK 123

Query: 1402 GEIEAHTDVYHNLDENSQKIL--RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN--IRS 1457
             E++    V  +  E  +  L  + LEG +      R L        E R +++   +R 
Sbjct: 124  RELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELP------PEERAQNVTRLLRK 177

Query: 1458 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1517
              E  + +W++L+L   +   W +  D+ L R          +Q+  D     + +LK +
Sbjct: 178  QAEEVNTEWEKLNLHSAD---WQRKIDETLER-------LQELQEATD-----ELDLKLR 222

Query: 1518 E-PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP-EERAQNVTRLLRK---------- 1565
            +  VI  + + V   L +   + LEK+     E+ P +E   +V  L R+          
Sbjct: 223  QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP 282

Query: 1566 ----QAEEVNTEWEKLNLHSADWQRKIDE 1590
                  E++NT W+ L +   D  R++ E
Sbjct: 283  YNLSTLEDLNTRWKLLQVAVEDRVRQLHE 311



 Score = 35.0 bits (79), Expect = 0.87
 Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)

Query: 926  LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 981
            L ++  + G  L  + ISP E    E+ L Q   Q +     L + +      I  + ++
Sbjct: 715  LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 773

Query: 982  LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 1041
             G+LE+ L DLEE+  +L      ++ Q E         P ++  T      + P   E+
Sbjct: 774  RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 829

Query: 1042 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 1098
            +++ + L + K   +   + LED + + ++ ++RL Q L   Q +     TT+ +  T
Sbjct: 830  IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 887



 Score = 31.6 bits (70), Expect = 9.6
 Identities = 42/234 (17%), Positives = 97/234 (41%), Gaps = 34/234 (14%)

Query: 375 VLKRLKAELNDIRPKVDSTRDQAANLMAN--------RGDHCRKLVEPQISELNHRFAAI 426
           +L R    + D++ ++++  D   NL  N         G     L++ ++  +N +++ +
Sbjct: 1   MLHRKTYHVKDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSEL 60

Query: 427 SHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKD------------ 474
                  K S+ ++   + +SD  K L     E+   + LK+++ ++             
Sbjct: 61  R------KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQK 114

Query: 475 MNEDNEGTVKELLQRGDNLQQRITDER---KREEIKIKQQLLQTKHNALKDLRSQR---- 527
            N+ +    +EL  +   +   +   R     + ++  ++L Q       + R+Q     
Sbjct: 115 QNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRL 174

Query: 528 -RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQK 580
            RK+A E++ +W +    + D  + +D+  ++L  L E  DE  +K    E+ K
Sbjct: 175 LRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIK 228


>gi|5032307 dystrophin Dp140c isoform [Homo sapiens]
          Length = 1105

 Score = 1888 bits (4891), Expect = 0.0
 Identities = 947/975 (97%), Positives = 952/975 (97%), Gaps = 4/975 (0%)

Query: 1120 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 1179
            MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1    MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60

Query: 1180 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 1239
            EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61   EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120

Query: 1240 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 1299
            DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121  DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180

Query: 1300 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 1359
            NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181  NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240

Query: 1360 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 1419
            FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241  FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300

Query: 1420 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 1479
            KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301  KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360

Query: 1480 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 1539
            LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361  LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420

Query: 1540 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 1599
            LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421  LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480

Query: 1600 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 1659
            EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481  EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540

Query: 1660 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 1719
            QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541  QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600

Query: 1720 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 1779
            WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601  WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660

Query: 1780 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 1839
            LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661  LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720

Query: 1840 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 1899
            WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721  WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780

Query: 1900 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 1959
            SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781  SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840

Query: 1960 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 2019
            VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841  VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900

Query: 2020 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTV-LEGDNMETPVTLINFWPVD 2078
            TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQ +  E D ++         P+ 
Sbjct: 901  TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQNLQAEYDRLKQQHEHKGLSPLP 960

Query: 2079 SAP---ASSPQLSHD 2090
            S P    +SPQ   D
Sbjct: 961  SPPEMMPTSPQSPRD 975



 Score =  332 bits (851), Expect = 3e-90
 Identities = 167/168 (99%), Positives = 168/168 (100%)

Query: 2177 RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 2236
            +NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ
Sbjct: 938  QNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 997

Query: 2237 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 2296
            ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS
Sbjct: 998  ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 1057

Query: 2297 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2344
            DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 1058 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 1105



 Score =  100 bits (249), Expect = 2e-20
 Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)

Query: 664  THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 722
            T ++  L  ++Q++ +  +   D ED+ +     K     L+Q   +++ +I + +    
Sbjct: 20   TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79

Query: 723  QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 780
            +++    R  + + + ++  QW++V +  ++R+ + +            +K   QWL   
Sbjct: 80   KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129

Query: 781  -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 830
             EAEQ L + +   E+W+   Y            K+L   + Q QT V   N    ++++
Sbjct: 130  EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189

Query: 831  QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 890
              S  D   +     ++N  W+ + K++S+R+  LEE   +L +F  DL +F+ WL EA+
Sbjct: 190  DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249

Query: 891  NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 943
              A++  +  ++++L E  + VK L+++    QG       +   L+E    +L S   S
Sbjct: 250  TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309

Query: 944  PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 1003
             ++   L+ +L   N +W ++ +     +  +EA      +L   L++       LL+WL
Sbjct: 310  -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361

Query: 1004 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 1063
                   E+  Q    G F       AVQ KQ DV     +   L  ++P        + 
Sbjct: 362  Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410

Query: 1064 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 1120
               +E   + + +L QE R   P+             Q VT L+ +      T   KL +
Sbjct: 411  IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460

Query: 1121 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 1174
             S+    ++    +  +   E TD L L     +VIK     VGDL  + + + + K KA
Sbjct: 461  HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520

Query: 1175 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 1234
               ++   +  +  +   A+ L           + T  +E +  +W  +Q  +++R +QL
Sbjct: 521  LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578

Query: 1235 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 1289
            +E  +D    S  +L    +       +  K+  +      T      K+TE  Q   DL
Sbjct: 579  HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638

Query: 1290 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 1340
               + +          +   L L LL   +A D    H + +N        I   ++   
Sbjct: 639  NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698

Query: 1341 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 1395
              LE+ H  L   PL ++  L WL     T       T + R+L    G+  L K
Sbjct: 699  DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 128/599 (21%), Positives = 244/599 (40%), Gaps = 58/599 (9%)

Query: 242 LTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 301
           LT+WL+  D  +  +  + G   +++  +   KAT +++E+++  L+ +    + LK   
Sbjct: 22  LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81

Query: 302 GKKE--TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADT 359
             +E  T++ D++  + + W  V    +     L E  K    + +  +   + + QA  
Sbjct: 82  SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141

Query: 360 LLDESEKKKP------QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVE 413
            L ES K+ P      Q+K    K+L  +L   +  VD   D A  L+ +      + V 
Sbjct: 142 KL-ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 200

Query: 414 PQISELNHRFAAISHRIKTGKASI--PLKELEQFNSDIQKLLEPL-EAEIQQGVNLKEED 470
                +N  + +I  R+   +A++    + L+QF  D++K L  L EAE    V L++  
Sbjct: 201 MITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV-LQDAT 259

Query: 471 FNKDMNEDNEGTVKELLQRGDNLQQRI---------TDERKREEIKIKQ-----QLLQTK 516
             + + ED++G VKEL+++  +LQ  I          DE  ++ ++  +      LLQ +
Sbjct: 260 RKERLLEDSKG-VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR 318

Query: 517 HNALKDLRSQRRKKALEI-------SHQWYQYKRQADDLLKCLDDIEKKLA-SLPEPRDE 568
            + +    S+ RKK+L I       S QW +      +LL  L   + +L+   P   D 
Sbjct: 319 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDF 378

Query: 569 RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 628
             +++ +   +  K EL           E       E     L K ++E      + R  
Sbjct: 379 PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQ 438

Query: 629 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 688
           N  ++  +R++   V TE   L +    + +  +I    + L E+++  +  DL  +  E
Sbjct: 439 NVTRL--LRKQAEEVNTEWEKLNLH--SADWQRKIDETLERLQELQEATDELDLKLRQAE 494

Query: 689 DLFKQEESLKNIK-DSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQ---- 743
            +    + + ++  DSLQ    ++  +  +     ++ + V    L   L+ L  Q    
Sbjct: 495 VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVN--DLARQLTTLGIQLSPY 552

Query: 744 ----WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHA 798
                E +N  +K  Q   +  V +    H D          A Q    T +   WE A
Sbjct: 553 NLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRD-------FGPASQHFLSTSVQGPWERA 604



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 87/493 (17%), Positives = 199/493 (40%), Gaps = 64/493 (12%)

Query: 50  KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM-------KKHNQGKEAA------ 96
           K     + D  D  +M  + +    DL      LEE+       K     +EA       
Sbjct: 34  KSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDR 93

Query: 97  -QRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 154
            +R+ +Q D  Q+ LQ+   +   + +    + +  +E++ +L + +  L + +      
Sbjct: 94  IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTV 153

Query: 155 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 214
           + +Q ++     L K L + ++ V++      ++++    ++ +++      +   +  +
Sbjct: 154 DAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSI 213

Query: 215 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG- 273
             +V+ER+  LE+  +L ++   ++     WL  T+ E T     +        E + G 
Sbjct: 214 HKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGV 271

Query: 274 KATQKEIEKQKVHLKSITEV--------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTS 324
           K   K+ +  +  +++ T+V         + L+++ G  +  L++ +L  +N  W  +  
Sbjct: 272 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRK 331

Query: 325 RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP--------QQKEDVL 376
           ++    + L       +    ++  +  W+   D   DE  ++ P        Q++ DV 
Sbjct: 332 KSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVH 388

Query: 377 KRLKAELNDIRPKVDSTRDQAANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGK 434
           +  K EL    P + ST +     +  +  +   KL  EP+      R   ++  ++   
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--- 445

Query: 435 ASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ 494
                K+ E+ N++ +KL            NL   D+ + ++E  E  ++EL +  D L 
Sbjct: 446 -----KQAEEVNTEWEKL------------NLHSADWQRKIDETLE-RLQELQEATDELD 487

Query: 495 QRITDERKREEIK 507
            ++   R+ E IK
Sbjct: 488 LKL---RQAEVIK 497


>gi|110611228 utrophin [Homo sapiens]
          Length = 3433

 Score = 1558 bits (4034), Expect = 0.0
 Identities = 930/2372 (39%), Positives = 1392/2372 (58%), Gaps = 118/2372 (4%)

Query: 24   LEQSIQSAQETEKSLHLIQESLT-----FIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS 78
            L +S + A   +K L  +QE +T     ++++       +++++A   +E ++ + D+  
Sbjct: 1120 LSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAV--EEMKRAKEDVLQ 1177

Query: 79   HEISLEEMKKHNQGKEA-----AQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQ-- 131
             E+ ++ +K + +   A      Q + S+++V  +  Q +  + R   K    E+     
Sbjct: 1178 KEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIR--GKCHTLEEVWSCW 1235

Query: 132  -ESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV----KSEVEMVIKTGR 186
             E    LD     L  LE +    EV+  + +      +SL  V          + + G+
Sbjct: 1236 IELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQ 1295

Query: 187  QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 246
             ++     ++   + E++ A    Y +L      ++  LEK L++ R+  + + VL E L
Sbjct: 1296 TLIDGGILDDI--ISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESL 1353

Query: 247  AATDMELTK----RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 302
               D +LT     R     +P       A   A +  +E+ + +++S        +T  G
Sbjct: 1354 GELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARG 1413

Query: 303  KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 362
              +  V  +     S    +  +   +   +L+ ++ ++     +  +    +  D +  
Sbjct: 1414 GSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVI-- 1471

Query: 363  ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 422
                   Q   D   +L   L++++ +V++      +++  +     K ++ Q++ L   
Sbjct: 1472 -------QTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVL 1524

Query: 423  FAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDF-NKDMNEDNEG 481
            +  +  ++  GK     ++LE+  S + + ++   A + + ++  E +   K  +E   G
Sbjct: 1525 YNDLGAQVTEGK-----QDLERA-SQLARKMKKEAASLSEWLSATETELVQKSTSEGLLG 1578

Query: 482  TVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQY 541
             +   +    N+ + +  E+++ ++    +      N ++       ++   ++  W + 
Sbjct: 1579 DLDTEISWAKNVLKDL--EKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRV 1636

Query: 542  KRQADDLLKCLDDIEKKLASLPEP---------RDERKIKEIDRELQKKKEELNAVRRQA 592
            +   +D    L + + +L               + E  + EI+++   K+EE+  V+R  
Sbjct: 1637 RTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEI--VKRLV 1694

Query: 593  EGLSEDGAAMAVEPTQIQL--------SKRWREIESKFAQFRRLNFAQIHTVREETMMVM 644
              L  D A + VE  + Q         S     +E K A+  R NF ++    +   +++
Sbjct: 1695 SEL--DDANLQVENVRDQALILMNARGSSSRELVEPKLAELNR-NFEKVSQHIKSAKLLI 1751

Query: 645  TEDMPLEISYVPSTYLTEITHVSQALLE--VEQLLNAPDLCAKDFEDLFKQEESLKNIKD 702
             ++   +      T+ T +       LE  +E +L   +   +  ++  K +E    I++
Sbjct: 1752 AQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEE 1811

Query: 703  SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV 762
             LQ+     +++H             E+++LQ  L    +   K   + + + G+    +
Sbjct: 1812 VLQRGE---EMLHQP-----MEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGI 1863

Query: 763  EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY------LKELQDGIGQRQT 816
                     +   N+ L   +       +PE    A Y+ +      LK ++D + +   
Sbjct: 1864 RSSLLPTDYLVEINKILLCMDDVELSLNVPE-LNTAIYEDFSFQEDSLKNIKDQLDKLGE 1922

Query: 817  VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 876
             +  ++    ++I ++S  +A  +++ L  LN +W  + +  SDRK   +       +F 
Sbjct: 1923 QIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFH 1982

Query: 877  RDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGP 935
             DLN+   W+ EA+ +      PG    L K ++ Q +L V  +   Q     LN TG  
Sbjct: 1983 CDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVG-ISSHQPSFAALNRTGDG 2041

Query: 936  VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQ 995
            ++    +S  +   L+ KL   N +W  +   + ++Q  ++ +        K++     Q
Sbjct: 2042 IVQK--LSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGE-------SKQVMKYRHQ 2092

Query: 996  LNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI--LSKGQ-HLYKEK 1052
            L+ ++ WL+   + ++   +   E   ++QE     Q  +   E++  L++ +  +  +K
Sbjct: 2093 LDEIICWLTKAEHAMQ--KRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDK 2150

Query: 1053 PATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKE 1112
              + P + K+   S   + VN    ++  + P          +S +QT  +   P V K 
Sbjct: 2151 SLSLPERDKI---SESLRTVNMTWNKICREVPTTLKECIQEPSSVSQT-RIAAHPNVQKV 2206

Query: 1113 TAISK---LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMI 1169
              +S    + + S    E+   AD ++  TEL DWL L+DQ++KS  V VGD+E+IN+ +
Sbjct: 2207 VLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTV 2266

Query: 1170 IKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQN 1229
             + K T  DLEQR PQL+ + T AQNLKNK S+ + RT IT+++ER++NQWD  Q  ++ 
Sbjct: 2267 SRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVEL 2326

Query: 1230 RRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDL 1289
            R+QQL +M+ DS QW + +EE E+++ +  A+L   ++     D + K+I++ + L ++L
Sbjct: 2327 RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARR--DPLTKQISDNQILLQEL 2384

Query: 1290 RQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRL 1349
                  V   +++  KLL +Y +DDTR V   TE +  SW ++ + +++R+ ALE   R 
Sbjct: 2385 GPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRT 2444

Query: 1350 LQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTD 1409
            +Q    DLE FL W+ EAETT NVL DA+ +E  L+DS   +EL +Q QD+Q EI+AH D
Sbjct: 2445 VQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHND 2504

Query: 1410 VYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRL 1469
            ++ ++D N QK++++L  S++A +LQ RLD+MN +W++L+ KS +IR+HLEAS+++W RL
Sbjct: 2505 IFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRL 2564

Query: 1470 HLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVR 1529
             +SL+EL+ WL +KD+EL +Q PIGGD PA+Q Q D  +A +RELK KE  +++ ++  R
Sbjct: 2565 LMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQAR 2624

Query: 1530 IFLTEQPLEGLE---KLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQR 1586
            +FL +QP+E  E   +  Q   EL PEERAQ + + +RKQ+ EV  +WE LN  +++WQ+
Sbjct: 2625 VFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQK 2684

Query: 1587 KIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAP 1646
            ++D+ LE+L++LQ A D+LD  +++AE ++  W+PVGDLLIDSLQDH+EK+ A R EIAP
Sbjct: 2685 QVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAP 2744

Query: 1647 LKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGP 1706
            +   V  VNDL+ QL+ L +  S      L+DLN RWKLLQV+V+DR++QL EAHRDFGP
Sbjct: 2745 INFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGP 2804

Query: 1707 ASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYR 1766
            +SQHFLSTSVQ PW+R+IS NKVPYYINH+TQTTCWDHPKMTEL+QSLADLNNVRFSAYR
Sbjct: 2805 SSQHFLSTSVQLPWQRSISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYR 2864

Query: 1767 TAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNN 1826
            TA+K+RRLQKALCLDLL LS   +   QH L QNDQ + +  +INCLTT YD LEQ H +
Sbjct: 2865 TAIKIRRLQKALCLDLLELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKD 2924

Query: 1827 LVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTG 1886
            LVNVPLCVDMCLNWLLNVYDTGRTG+IRV S K G++SL K  LE+KYRYLFK+VA  T 
Sbjct: 2925 LVNVPLCVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTE 2984

Query: 1887 FCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRL 1946
             CDQR+LGLLLHD+IQIPRQLGEVA+FGGSNIEPSVRSCFQ  NNKPEI    F+DWM L
Sbjct: 2985 MCDQRQLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHL 3044

Query: 1947 EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVA 2006
            EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI+GFRYRSLKHFNYD+CQSCFFSGR A
Sbjct: 3045 EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTA 3104

Query: 2007 KGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNME 2066
            KGHK+HYPMVEYC PTTSGEDVRDF KVLKNKFR+K+YFAKHPR+GYLPVQTVLEGDN+E
Sbjct: 3105 KGHKLHYPMVEYCIPTTSGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLE 3164

Query: 2067 TPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDD 2126
            TP+TLI+ WP    P+ SPQL HDDTHSRIE YA+RLA+ME +NGS+L DS S   S++D
Sbjct: 3165 TPITLISMWPEHYDPSQSPQLFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVED 3224

Query: 2127 EHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRL 2186
            EH LIQ YCQ+L  +SP+SQP+SPAQIL S+E EERGELERI+ADLEEE RNLQ EY++L
Sbjct: 3225 EHALIQQYCQTLGGESPVSQPQSPAQILKSVEREERGELERIIADLEEEQRNLQVEYEQL 3284

Query: 2187 KQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLE 2246
            K QH  +GL P+ SPPE + +   +  D+ELIAEAKLLRQHKGRLEARMQILEDHNKQLE
Sbjct: 3285 KDQHLRRGL-PVGSPPESIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLE 3343

Query: 2247 SQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLS 2306
            SQLHRLRQLLEQP++++++NG    SP  S Q S  S  +     G Q   + G EDLL+
Sbjct: 3344 SQLHRLRQLLEQPESDSRINGV---SPWASPQHSALSYSLDPDASGPQFHQAAG-EDLLA 3399

Query: 2307 PPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKP 2338
            PP DTST L EVMEQ++++FPS    N P +P
Sbjct: 3400 PPHDTSTDLTEVMEQIHSTFPSC-CPNVPSRP 3430



 Score =  525 bits (1353), Expect = e-148
 Identities = 426/1574 (27%), Positives = 768/1574 (48%), Gaps = 211/1574 (13%)

Query: 17   AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL 76
            A  +Q  LE+ +Q  +ET++ L ++QESL  +DKQL  Y+ D++DA Q+PQEAQKIQ+++
Sbjct: 1325 AESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEI 1384

Query: 77   TSHEISLEEMKKHNQGKEAAQ------RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRL 130
            ++HE++LEE++++ + +          R  SQ+DV Q+KL++VS KF+LFQKPANFEQR+
Sbjct: 1385 SAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRM 1444

Query: 131  QESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQ 190
             + K +LD VK  L  L+ K V+ +V+Q+ L+ C+ LYK+LSEVK EVE VIKTGR IVQ
Sbjct: 1445 LDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQ 1504

Query: 191  KKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATD 250
            K+QT+NPK +DE++T+LK+ YN+LGA+VTE KQ LE+  +L+RKM+KE   L+EWL+AT+
Sbjct: 1505 KQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATE 1564

Query: 251  MELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVED 310
             EL ++S  EG+  +LD+E++W K   K++EK+K  L +ITE   AL+ ++   E ++E+
Sbjct: 1565 TELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPILEE 1624

Query: 311  KLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQ 370
            +L +LN+ W  V +  E+W N L+ +Q  +E FD NV HI+ W+ QA+ LLDE EKK   
Sbjct: 1625 RLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTS 1684

Query: 371  QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI 430
            ++E+++KRL +EL+D   +V++ RDQA  LM  RG   R+LVEP+++ELN  F  +S  I
Sbjct: 1685 KQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHI 1744

Query: 431  KTGK-------------------ASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDF 471
            K+ K                     +P  +LE+  +DI+ +L+ +E       +L+  D 
Sbjct: 1745 KSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEK------HLESSDE 1798

Query: 472  NKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRK-- 529
            ++ M+E++   ++E+LQRG+ +  +  ++ K+E+I+++  LL T++N +K +  Q+RK  
Sbjct: 1799 DEKMDEES-AQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMG 1857

Query: 530  ---KALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR---------DERKIKEIDRE 577
                 +  S     Y  + + +L C+DD+E  L ++PE            E  +K I  +
Sbjct: 1858 QLASGIRSSLLPTDYLVEINKILLCMDDVELSL-NVPELNTAIYEDFSFQEDSLKNIKDQ 1916

Query: 578  LQKKKEELNAVRRQAEGLSEDGA---AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIH 634
            L K  E++  +  +   +  + +   A+ +  T  QL+ +W  I   ++  +      + 
Sbjct: 1917 LDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAME 1976

Query: 635  TVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE-DLFKQ 693
              R+                    +  ++  ++Q + E E+LL   D CA     DL K 
Sbjct: 1977 EWRQ--------------------FHCDLNDLTQWITEAEELL--VDTCAPGGSLDLEKA 2014

Query: 694  EESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKD 753
                + ++  +         ++      +Q  +  +   L+E L+ L+ +W+ +    KD
Sbjct: 2015 RIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKD 2074

Query: 754  RQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQ 813
            RQ R     ++  ++ + +     WLT+AE  ++K    E  E+ +    L++L   +  
Sbjct: 2075 RQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQ---ELRDLTQEMEV 2131

Query: 814  RQTVVRTLNATGEEIIQQSSKT--DASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNI 871
                ++ LN T  E++   S +  +   + E L ++N+ W ++C+++    K   ++ + 
Sbjct: 2132 HAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSS 2191

Query: 872  LSEFQ----RDLNEFVLWLEEAD--------NIASIPLEPGK------------EQQLKE 907
            +S+ +     ++ + VL    +D        +  SIP +  K            +Q LK 
Sbjct: 2192 VSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKS 2251

Query: 908  KL------EQVKLLVEELPLRQGILKQLNE------TGGPVLVSAPISPEEQDKLENKLK 955
             +      E++   V  + + +  L+Q +       T    L +   S + +  +  KL+
Sbjct: 2252 NIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLE 2311

Query: 956  QTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQ 1015
            +   QW      +  +Q ++E  I D  Q +   E+ EE +            +L I  Q
Sbjct: 2312 RVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMR-------KYEARLYILQQ 2364

Query: 1016 PNQEG-PFDVQETEIAVQAKQPDVEEILSKGQHLYK-----EKPATQPVKRKLEDLSSEW 1069
              ++     + + +I +Q   P    +++    L K         T+ VK   E L + W
Sbjct: 2365 ARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSW 2424

Query: 1070 KAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVP 1129
              +N L Q +  +Q  L     T+ AS       + + +   ET ++             
Sbjct: 2425 --IN-LKQSIADRQNALEAEWRTVQASRRDLENFL-KWIQEAETTVN------------- 2467

Query: 1130 ALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEEL 1189
             L D +     L D  S+L + +K Q      ++DI   I       + ++  R      
Sbjct: 2468 VLVDASHRENALQD--SILARELKQQ------MQDIQAEIDAHNDIFKSIDGNR------ 2513

Query: 1190 ITAAQNLKNKTSNQEARTIITDRIERIQNQWDE-------VQEHLQNRRQQLNEM---LK 1239
                Q +     N E  T++  R++ +  +W++       ++ HL+   ++ N +   L+
Sbjct: 2514 ----QKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLE 2569

Query: 1240 DSTQWLEAKEEAEQVLGQARAKLESWKEGPY--TVDAIQKKITETKQLAKDLRQWQTNVD 1297
            +  +WL  K+E            E  K+ P    V A+Q +    K L ++L++ + +V 
Sbjct: 2570 ELIKWLNMKDE------------ELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVL 2617

Query: 1298 VANDLALKLLRDY----SADDTRKVHMIT-----ENINASWRSIHKRVSEREAALEETHR 1348
             A D A   L D       +  R +   T     E      +++ K+ SE +   E  + 
Sbjct: 2618 NAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNA 2677

Query: 1349 LLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHT 1408
            +   +   ++K L  L + +   + L DA  KE     ++ V+   K   DL        
Sbjct: 2678 VTSNWQKQVDKALEKLRDLQGAMDDL-DADMKE-----AESVRNGWKPVGDL-------- 2723

Query: 1409 DVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSEL-RKKSLNIRSHLEASSDQWK 1467
             +  +L ++ +KI+   E         + +++++ + S L    SL +   L+  + +WK
Sbjct: 2724 -LIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWK 2782

Query: 1468 RLHLSLQELLVWLQ 1481
             L +S+ + L  LQ
Sbjct: 2783 LLQVSVDDRLKQLQ 2796



 Score =  137 bits (346), Expect = 9e-32
 Identities = 333/1726 (19%), Positives = 656/1726 (38%), Gaps = 264/1726 (15%)

Query: 70   QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQR 129
            Q +Q  +   +  LE   K   G    + + +  DV         +   +    A  E+ 
Sbjct: 887  QAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKA 946

Query: 130  LQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV 189
            LQE K + + ++   PAL   + E + ++               V  +VE + K     V
Sbjct: 947  LQEKKTLDEILENQKPALHKLAEETKALEKN-------------VHPDVEKLYKQEFDDV 993

Query: 190  QKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAAT 249
            Q K                  +N+L   V++    LE+     R    +  V+ +W+   
Sbjct: 994  QGK------------------WNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGV 1035

Query: 250  DMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKT--VLGKKETL 307
               L K+ A +G  + L  ++    A   EIE  +  LK++ E+   L++  V G K T 
Sbjct: 1036 KDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIK-TW 1094

Query: 308  VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADT--LLDESE 365
            V+ +L    +    ++       + L E Q+      +++  + +W+ QA+   L  + E
Sbjct: 1095 VQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFE 1154

Query: 366  KKKPQQKEDVLKRLKAELNDIRPK---VDSTRDQAANLMANRGDHCRKLVEPQISELN-- 420
             K P++ E  ++ +K    D+  K   V   +D    L A      ++L     SELN  
Sbjct: 1155 YKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELT----SELNVV 1210

Query: 421  -HRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDN 479
               +  + +RI+ GK       LE+  S   +LL  L+ E      L+E   + ++  + 
Sbjct: 1211 LENYQLLCNRIR-GKC----HTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEK 1265

Query: 480  EGTVKELLQRGDNLQQRITDERKR-EEI-----------KIKQQLLQTKHNALKDLRSQR 527
               V E L+  +++ +   D R +  E+            I  + L+  ++  +DL    
Sbjct: 1266 TDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLA 1325

Query: 528  RKKALEISHQWYQYKRQADDLLKCLD----DIEKKLASLPEPRDE-----RKIKEIDREL 578
              K + +  Q  Q  R+ D +L+ L     +++K+L +    R +     ++ ++I  E+
Sbjct: 1326 ESKQISLEKQ-LQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEI 1384

Query: 579  QKKKEELNAVRR--QAEGLSEDGAAMAVEPTQIQ-LSKRWREIESKFAQFRR-LNFAQIH 634
               +  L  +RR  +++ L+   +  A   +Q+  L ++ RE+ +KF  F++  NF    
Sbjct: 1385 SAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANF---- 1440

Query: 635  TVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE 694
                       E   L+   V      E+ HV    L+V+ +   PD+     +   K  
Sbjct: 1441 -----------EQRMLDCKRVLDGVKAEL-HV----LDVKDV--DPDVIQTHLDKCMKLY 1482

Query: 695  ESLKNIKDSLQQ--SSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 752
            ++L  +K  ++    +GR  I+  ++T   +         + E L+ L   +  +     
Sbjct: 1483 KTLSEVKLEVETVIKTGR-HIVQKQQTDNPKG--------MDEQLTSLKVLYNDLGAQVT 1533

Query: 753  DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE------NWEHAKYKWYLKE 806
            + +   +R+ +  R+   +    ++WL+  E  L +    E      + E +  K  LK+
Sbjct: 1534 EGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKD 1593

Query: 807  LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 866
            L+       T+  + +A  + +I+ S      IL+E+L  LN  W  V     D    L 
Sbjct: 1594 LEKRKADLNTITES-SAALQNLIEGSE----PILEERLCVLNAGWSRVRTWTEDWCNTLM 1648

Query: 867  EQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGIL 926
              +N L  F  ++     WL +A+ +    L+  +++   ++ E VK LV EL      L
Sbjct: 1649 NHQNQLEIFDGNVAHISTWLYQAEAL----LDEIEKKPTSKQEEIVKRLVSELD--DANL 1702

Query: 927  KQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRAL----------PEKQGEIE 976
            +  N     +++        ++ +E KL + N  + KVS+ +          P  Q  + 
Sbjct: 1703 QVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVT 1762

Query: 977  AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 1036
             +  + G     LE LE  + ++L ++               E   +  + +  +  +  
Sbjct: 1763 TETFETGVPFSDLEKLENDIENMLKFV---------------EKHLESSDEDEKMDEESA 1807

Query: 1037 DVEEILSKGQ---HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1093
             +EE+L +G+   H   E    + ++ +L  L + +  +  +  + R K   LA G+ + 
Sbjct: 1808 QIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQR-KMGQLASGIRS- 1865

Query: 1094 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 1153
               PT  +  + + ++  +     L +P    L      DF+     L +        IK
Sbjct: 1866 SLLPTDYLVEINKILLCMDDVELSLNVPE---LNTAIYEDFSFQEDSLKN--------IK 1914

Query: 1154 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 1213
             Q   +G+       +I +K     LE   P+  ++      L  K           DRI
Sbjct: 1915 DQLDKLGE----QIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAK----------WDRI 1960

Query: 1214 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1273
             R+ +      +      +Q +  L D TQW+    EAE++L    A        P    
Sbjct: 1961 NRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWI---TEAEELLVDTCA--------PGGSL 2009

Query: 1274 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1333
             ++K     ++L   +   Q +    N     +++  S  D   +      +N  W +I 
Sbjct: 2010 DLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIV 2069

Query: 1334 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1393
              V +R+  L+   + + ++   L++ + WLT+AE        A +K    E  + ++EL
Sbjct: 2070 AEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAE-------HAMQKRSTTELGENLQEL 2122

Query: 1394 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR------LDNMNFKWSE 1447
                +DL  E+E H +    L+    ++L     SD ++ L  R      L  +N  W++
Sbjct: 2123 ----RDLTQEMEVHAEKLKWLNRTELEML-----SDKSLSLPERDKISESLRTVNMTWNK 2173

Query: 1448 LRKK------------------------------------SLNIRSHLEASSDQWKRLHL 1471
            + ++                                     + ++SH  +       L  
Sbjct: 2174 ICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDK 2233

Query: 1472 SLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIF 1531
            ++ EL  WL L D  L       GD   + K     +  K +L+ + P +       +  
Sbjct: 2234 TITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNL 2293

Query: 1532 LTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV---NTEWEKLNLHSADWQR 1586
              +     +     E  E      +  Q+   L ++Q E++   + +W+     + +  R
Sbjct: 2294 KNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMR 2353

Query: 1587 KIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAP 1646
            K +  L  LQ  Q   D L  ++   +++     P GD ++ +  + L+K+    G    
Sbjct: 2354 KYEARLYILQ--QARRDPLTKQISDNQILLQELGP-GDGIVMAFDNVLQKLLEEYG---- 2406

Query: 1647 LKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVED 1692
              ++  +V +    L T  I L          L   W+ +Q +  D
Sbjct: 2407 -SDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRD 2451



 Score =  133 bits (334), Expect = 2e-30
 Identities = 244/1185 (20%), Positives = 461/1185 (38%), Gaps = 168/1185 (14%)

Query: 572  KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 631
            +++  +L  KK  +  +    E L +     A+   +    K  +E E +    +     
Sbjct: 231  EDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPE 290

Query: 632  QIH-TVREETMMVMTE-DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE- 688
            + H + R ET   +TE DM L+      +Y   +  V   LL  E      D  + D E 
Sbjct: 291  EEHESPRAETPSTVTEVDMDLD------SYQIALEEVLTWLLSAEDTFQEQDDISDDVEE 344

Query: 689  --DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEK 746
              D F   E+      + Q S G + +    +     + +  E  ++QE ++ L+ +WE 
Sbjct: 345  VKDQFATHEAFMMELTAHQSSVGSV-LQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEA 403

Query: 747  VNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL-- 804
            +     DRQ R    + + ++    ++  + WLT  E+ ++K +     +  K    L  
Sbjct: 404  LRVESMDRQSRLHDVLMELQK--KQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLE 461

Query: 805  --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 862
              K LQ  +   Q  V +L      + + S ++  +IL+++L  L  RW  VC+   +R 
Sbjct: 462  EHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERW 521

Query: 863  KRLEEQKNILSEFQRDLNEFVLWL-EEADNIASIPLEPGKEQ-QLKEKLEQVKLLVEELP 920
             RL+E   +  E   +      WL E+ + +  +     K+Q +L   + ++ +L E++ 
Sbjct: 522  NRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDME 581

Query: 921  LRQGILKQLNETG---GPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 977
            +++  L QL+E G   G +L ++  S     K+ +  ++   +W  + + L +   ++  
Sbjct: 582  MKRQTLDQLSEIGQDVGQLLDNSKAS----KKINSDSEELTQRWDSLVQRLEDSSNQVTQ 637

Query: 978  QIKDLGQLEKKLEDL--------------------------------------------E 993
             +  LG  +   +DL                                             
Sbjct: 638  AVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISA 697

Query: 994  EQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQ----PDVEEILSKGQHLY 1049
            E LN +L W + I+   EI      +   ++++   A++ +Q    P  +E+   GQ L 
Sbjct: 698  ELLNWILKWKTAIQT-TEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILV 756

Query: 1050 ----KEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK---QPDLAPGLTTIGASPTQTVT 1102
                KE   T+ +K  LE +SSEWK V++ L++L  K   Q D+      +         
Sbjct: 757  EQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDE------- 809

Query: 1103 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 1162
             + + + TKE  +    +  S    +P+L D      ELT+ L L               
Sbjct: 810  -LEKVIKTKEEWVKHTSISESSRQSLPSLKD--SCQRELTNLLGL--------------- 851

Query: 1163 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 1222
                                 P++E    +   L ++ S   A   +    +    ++  
Sbjct: 852  --------------------HPKIEMARASCSALMSQPS---APDFVQRGFDSFLGRYQA 888

Query: 1223 VQEHLQNRRQQLNEMLKDST--QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKIT 1280
            VQE +++R+Q L   LK      +LE  +  + VL  +  K +        +  ++K + 
Sbjct: 889  VQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQ 948

Query: 1281 ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSERE 1340
            E K L + L   +  +    +    L ++   D  +      +++   W  +   VS   
Sbjct: 949  EKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVS--- 1005

Query: 1341 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLE-DSKGVKELMKQWQD 1399
               ++ H LL++  L L  F A  T  E   + ++D   K++  + D  G++  + Q   
Sbjct: 1006 ---KDLH-LLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSA 1061

Query: 1400 LQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHL 1459
               EIE       N+ E  +  LRS   +     +Q RL +   +  +L K+    +S L
Sbjct: 1062 FVNEIETIESSLKNMKE-IETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRL 1120

Query: 1460 EASSDQWKRLHLSLQELLVWL-QLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 1518
              S ++   L   L E+  W+ Q +++ L R               ++ RA K ++  KE
Sbjct: 1121 SESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRA-KEDVLQKE 1179

Query: 1519 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 1578
              +    + +++   + P  G E   +    L   +   N  R      EEV + W +L 
Sbjct: 1180 VRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIEL- 1238

Query: 1579 LHSAD----WQRKIDETLERLQELQEATDELDLKLRQAEVI-------KGSWQPVGDLLI 1627
            LH  D    W   ++E ++  + L E TD ++  L   E +       +   + +G  LI
Sbjct: 1239 LHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLI 1298

Query: 1628 DS--LQDHL-EKVKALRGEIAPLKENVSHVND-----LARQLTTL 1664
            D   L D + EK++A         E++SH+ +     L +QL  L
Sbjct: 1299 DGGILDDIISEKLEAFNSRY----EDLSHLAESKQISLEKQLQVL 1339



 Score =  117 bits (294), Expect = 1e-25
 Identities = 324/1651 (19%), Positives = 642/1651 (38%), Gaps = 298/1651 (18%)

Query: 130  LQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKS-------LSEVKSEVEMVI 182
            L   ++ L+EV   L + E    EQ+ +   +    + + +       L+  +S V  V+
Sbjct: 311  LDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVL 370

Query: 183  KTGRQIVQKK--QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMN 240
            + G Q++ +     E   E+ E++T L   +  L  +  +R+ +L   L   +K  K++ 
Sbjct: 371  QAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQK--KQLQ 428

Query: 241  VLTEWLAATDMELTKRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALK 298
             L+ WL  T+  + K     ++    +L   +   K+ Q ++E ++V + S+T +   + 
Sbjct: 429  QLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVD 488

Query: 299  TVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQA 357
               G+  T ++ED+L  L   W AV    EE  N L           Q ++ + + +++ 
Sbjct: 489  ENSGESATAILEDQLQKLGERWTAVCRWTEERWNRL-----------QEINILWQELLEE 537

Query: 358  DTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQIS 417
              LL    K    +KE+ L +++           + +DQ                  ++S
Sbjct: 538  QCLL----KAWLTEKEEALNKVQTS---------NFKDQK-----------------ELS 567

Query: 418  ELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNE 477
                R A +   ++  + +  L +L +   D+ +LL+  +A             +K +N 
Sbjct: 568  VSVRRLAILKEDMEMKRQT--LDQLSEIGQDVGQLLDNSKA-------------SKKINS 612

Query: 478  DNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQ 537
            D+E    EL QR D+L QR+ D   +    + +  L       KDL    R +   I+ +
Sbjct: 613  DSE----ELTQRWDSLVQRLEDSSNQVTQAVAK--LGMSQIPQKDLLETVRVREQAITKK 666

Query: 538  WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVR-------R 590
                               K+    P P  +R+I  +D E +KK + ++A         +
Sbjct: 667  ------------------SKQELPPPPPPKKRQI-HVDIEAKKKFDAISAELLNWILKWK 707

Query: 591  QAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDM-- 648
             A   +E    M ++ T  ++ K+ + +E +  Q  R+  A       +T  ++ E M  
Sbjct: 708  TAIQTTEIKEYMKMQDTS-EMKKKLKALEKE--QRERIPRAD---ELNQTGQILVEQMGK 761

Query: 649  ----PLEISYVPSTYLTEITHVSQAL------LEVEQLLNAPDLCAKDFEDLFKQEE--- 695
                  EI  V     +E  +VSQ L      +++++ +NA      + E + K +E   
Sbjct: 762  EGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWV 821

Query: 696  -----------SLKNIKDSLQQSSGRIDIIHSKKTAALQSAT-----PVERVKLQEALSQ 739
                       SL ++KDS Q+    +  +H K   A  S +     P     +Q     
Sbjct: 822  KHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDS 881

Query: 740  LDFQWEKVNKMYKDRQGRFDRSVEKWRRFHY--DIKIFNQWLTEAEQFLRKTQIPENW-- 795
               +++ V +  +DRQ   +  ++      Y   +K     L ++E    K Q+  N   
Sbjct: 882  FLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSE---NKAQVSLNVLN 938

Query: 796  EHAKYKWYLKELQ--DGIGQRQTVVRTLNATGEEIIQQSSKTDA-SILQEKLGSLNLRWQ 852
            + AK +  L+E +  D I + Q       A   + ++++   D   + +++   +  +W 
Sbjct: 939  DLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWN 998

Query: 853  EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIPLEPGKEQQLKEKLEQ 911
            ++   +S     LEE    L  F+ D      W++   D +       G +  L+ +L+Q
Sbjct: 999  KLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQ 1058

Query: 912  VKLLVEELPLRQGILKQLNE-----TGGPVLVSAPISPEEQDKL---ENKLKQTNLQWIK 963
                V E+   +  LK + E       GPV   A I    Q +L   + +L++ + +   
Sbjct: 1059 CSAFVNEIETIESSLKNMKEIETNLRSGPV---AGIKTWVQTRLGDYQTQLEKLSKEIAT 1115

Query: 964  VSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQ-LNHLLLWLSPIRNQLEIYNQPNQEGPF 1022
                L E Q +     KDL ++++ +   EE+ L     + SP   +LE   +  +    
Sbjct: 1116 QKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSP--EELESAVEEMKRAKE 1173

Query: 1023 DVQETEIAVQAKQPDVEEILSK----GQHLYKE--------KPATQPVKRKLEDLSSEWK 1070
            DV + E+ V+  + +++ + +K    GQ L  E        +     ++ K   L   W 
Sbjct: 1174 DVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWS 1233

Query: 1071 AVNRLLQ------------ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI--- 1115
                LL             E R K  ++ P  T       +++  V +      T I   
Sbjct: 1234 CWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIREL 1293

Query: 1116 ---------------SKLEMPSSLMLEVPALADFNRAWTE-LTDWLSLLDQVIKSQRVMV 1159
                            KLE  +S   ++  LA+  +   E     L   DQ+++  +  +
Sbjct: 1294 GQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESL 1353

Query: 1160 GDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ-NLKNKTSNQEARTIIT--DRIERI 1216
            G+L+      +  +     + Q   +++  I+A +  L+    N  ++ + +   R  R 
Sbjct: 1354 GELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARG 1413

Query: 1217 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 1276
             +Q D +Q  L+    +  ++ +    + +   + ++VL   +A+L          D IQ
Sbjct: 1414 GSQMDVLQRKLREVSTKF-QLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQ 1472

Query: 1277 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV 1336
              + +  +L K L + +  V+        +++    D+ + +     ++   +  +  +V
Sbjct: 1473 THLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQV 1532

Query: 1337 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLED-------SKG 1389
            +E +  LE   +L ++   +      WL+  ET   ++Q +T  E LL D       +K 
Sbjct: 1533 TEGKQDLERASQLARKMKKEAASLSEWLSATET--ELVQKST-SEGLLGDLDTEISWAKN 1589

Query: 1390 V-KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSEL 1448
            V K+L K+  DL           + + E+S  +   +EGS+   +L+ RL  +N  WS +
Sbjct: 1590 VLKDLEKRKADL-----------NTITESSAALQNLIEGSEP--ILEERLCVLNAGWSRV 1636

Query: 1449 RKKSLNIRSHLEASSDQWKRLHLSLQELLVWL--------------QLKDDELSRQAPIG 1494
            R  + +  + L    +Q +    ++  +  WL                K +E+ ++    
Sbjct: 1637 RTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSE 1696

Query: 1495 GDFPAVQKQN-------------------------DVHRAFKR--------ELKTKEPVI 1521
             D   +Q +N                         +++R F++        +L   +  +
Sbjct: 1697 LDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPL 1756

Query: 1522 MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHS 1581
               L T   F T  P   LEKL         E   +N+ + + K  E  + E EK++  S
Sbjct: 1757 YQCLVTTETFETGVPFSDLEKL---------ENDIENMLKFVEKHLES-SDEDEKMDEES 1806

Query: 1582 ADWQRKIDETLERLQEL--QEATDELDLKLR 1610
            A    +I+E L+R +E+  Q   D    K+R
Sbjct: 1807 A----QIEEVLQRGEEMLHQPMEDNKKEKIR 1833



 Score =  112 bits (281), Expect = 3e-24
 Identities = 294/1589 (18%), Positives = 628/1589 (39%), Gaps = 227/1589 (14%)

Query: 166  NLYKSLSEVKSEV-EMVIKTGR-QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQ 223
            +L + L +  ++V + V K G  QI QK   E  +  ++ +T  K    EL      +K+
Sbjct: 623  SLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAIT--KKSKQELPPPPPPKKR 680

Query: 224  QLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG-KATQKEIEK 282
            Q+   ++  +K       L  W+      +      E M     SE+    KA +KE  +
Sbjct: 681  QIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRE 740

Query: 283  QKVHLKSITEVGEALKTVLGKKETLVEDKLSLL---NSNWIAVTSRAEEWLNLLLEYQKH 339
            +      + + G+ L   +GK+    E+  ++L   +S W  V+   E+ L   ++ Q+ 
Sbjct: 741  RIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLED-LERKIQLQED 799

Query: 340  METFDQNVDHITKWIIQAD-----TLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTR 394
            +  + + +D + K I   +     T + ES ++     +D  +R    L  + PK++  R
Sbjct: 800  INAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMAR 859

Query: 395  DQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASI-------PLKELEQFNS 447
               + LM+         V+        R+ A+   ++  +  +       P     +   
Sbjct: 860  ASCSALMSQPS--APDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLK 917

Query: 448  DIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIK 507
             ++ +L   E + Q  +N+  +    +     + T+ E+L+       ++ +E K  E  
Sbjct: 918  TLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKN 977

Query: 508  I--------KQQL--LQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 557
            +        KQ+   +Q K N LK L S+      EI+     ++  +  + K +D ++ 
Sbjct: 978  VHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKD 1037

Query: 558  KLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLS----- 612
             L      + +      D  LQ++ ++ +A   + E +      M    T ++       
Sbjct: 1038 FLMKQQAAQGD------DAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGI 1091

Query: 613  KRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLT-EITHVSQALL 671
            K W  ++++   ++     Q+  + +E   + T+   L  S   +  L  ++  + + + 
Sbjct: 1092 KTW--VQTRLGDYQ----TQLEKLSKE---IATQKSRLSESQEKAANLKKDLAEMQEWMT 1142

Query: 672  EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 731
            + E+     D   K  E+L    E +K  K+ + Q   R+ I+       L +  P    
Sbjct: 1143 QAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDN-IKLLAAKVPSGG- 1200

Query: 732  KLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW----RRFHYDIKIFNQWLTEAEQFLR 787
              QE  S+L+   E    +    +G+     E W       HY + +   WL   E+ ++
Sbjct: 1201 --QELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHY-LDLETTWLNTLEERMK 1257

Query: 788  KTQI-PENWEHAKYKWYLKELQDGI---GQRQTVVRTLNATGEEIIQQSSKTDASILQEK 843
             T++ PE  +       L+ L+  +      +T +R L   G+ +I      D  I+ EK
Sbjct: 1258 STEVLPEKTDAVNEA--LESLESVLRHPADNRTQIREL---GQTLIDGGILDD--IISEK 1310

Query: 844  LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE----- 898
            L + N R++++      ++  LE+Q  +L E  + L      L E D   +  L      
Sbjct: 1311 LEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDA 1370

Query: 899  ---PGKEQQLKEKLEQVKLLVEEL-------PL--------RQG-----ILKQLNETGGP 935
               P + Q+++ ++   +L +EEL       PL        R G     + ++L E    
Sbjct: 1371 FQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTK 1430

Query: 936  VLVSAPISPEEQDKLENK---------------------LKQTNL-QWIKVSRALPEKQG 973
              +    +  EQ  L+ K                     + QT+L + +K+ + L E + 
Sbjct: 1431 FQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKL 1490

Query: 974  EIEAQIKDLGQLEKKLE-----DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQE-T 1027
            E+E  IK    + +K +      ++EQL  L +  + +  Q+        EG  D++  +
Sbjct: 1491 EVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQV-------TEGKQDLERAS 1543

Query: 1028 EIAVQAKQ--PDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD 1085
            ++A + K+    + E LS  +    +K  ++ +   L DL +E      +L++L  ++ D
Sbjct: 1544 QLARKMKKEAASLSEWLSATETELVQKSTSEGL---LGDLDTEISWAKNVLKDLEKRKAD 1600

Query: 1086 LAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWL 1145
            L     T  ++  Q +   ++P++ +   +                A ++R  T   DW 
Sbjct: 1601 L--NTITESSAALQNLIEGSEPILEERLCVLN--------------AGWSRVRTWTEDWC 1644

Query: 1146 SLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELIT------------AA 1193
            + L        +  G++  I+  + + +A + ++E++    +E I               
Sbjct: 1645 NTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQV 1704

Query: 1194 QNLKNK------TSNQEARTIITDRIERIQNQWDEVQEHLQNRR----QQLNEMLKDSTQ 1243
            +N++++           +R ++  ++  +   +++V +H+++ +    Q+       +T+
Sbjct: 1705 ENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTE 1764

Query: 1244 WLEA----------KEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 1293
              E           + + E +L      LES  E    +D    +I E  Q  +++    
Sbjct: 1765 TFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDE-KMDEESAQIEEVLQRGEEMLHQP 1823

Query: 1294 TNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQF 1353
               +    + L+LL  ++  +  K   I +      R + +  S   ++L  T  L++  
Sbjct: 1824 MEDNKKEKIRLQLLLLHTRYNKIKAIPIQQ------RKMGQLASGIRSSLLPTDYLVE-- 1875

Query: 1354 PLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHN 1413
               + K L  + + E + NV +  T    + ED    ++ +K  +D   ++     V H 
Sbjct: 1876 ---INKILLCMDDVELSLNVPELNT---AIYEDFSFQEDSLKNIKDQLDKLGEQIAVIH- 1928

Query: 1414 LDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSL 1473
              E    ++    G  +A+ ++  L  +N KW  + +   + +   + + ++W++ H  L
Sbjct: 1929 --EKQPDVILEASG-PEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDL 1985

Query: 1474 QELLVWLQLKDDELSRQAPIGGDFPAV-----QKQNDV-----HRAFKRELKTKEPVIMS 1523
             +L  W+   ++ L      GG          Q++ +V       +F    +T + ++  
Sbjct: 1986 NDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQK 2045

Query: 1524 TLETVRIFLTEQPLEGL----EKLYQEPRELPPEERAQNVTRL-LRKQAEEVNTEWEKLN 1578
              +    FL E+ L GL    + +  E ++  P  + ++   +  R Q +E+   W    
Sbjct: 2046 LSQADGSFLKEK-LAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIIC-WLTKA 2103

Query: 1579 LHSADWQRKIDETLERLQELQEATDELDL 1607
             H+   +R   E  E LQEL++ T E+++
Sbjct: 2104 EHAMQ-KRSTTELGENLQELRDLTQEMEV 2131



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 80/381 (20%), Positives = 155/381 (40%), Gaps = 47/381 (12%)

Query: 1337 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 1396
            +E  + + E    L  + + LE+ L WL  AE T     D +      +D + VK+    
Sbjct: 298  AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDIS------DDVEEVKDQFAT 351

Query: 1397 WQDLQGEIEAH-TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 1455
             +    E+ AH + V   L   +Q I +     ++   +Q ++  +N +W  LR +S++ 
Sbjct: 352  HEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDR 411

Query: 1456 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ--APIGGDFPAVQKQNDVHRAFKRE 1513
            +S L     + ++  L  Q+L  WL L ++ + +    P+  D  ++QK  + H++ + +
Sbjct: 412  QSRLHDVLMELQKKQL--QQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSD 469

Query: 1514 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1573
            L+ ++  + S    V I                      E   ++ T +L  Q +++   
Sbjct: 470  LEAEQVKVNSLTHMVVIV--------------------DENSGESATAILEDQLQKLGER 509

Query: 1574 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1633
            W  +   + +   ++ E     QEL E    L   L + E      + +  +   + +D 
Sbjct: 510  WTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE------EALNKVQTSNFKDQ 563

Query: 1634 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL---------SPYNLSTLEDLNTRWK 1684
             E   ++R  +A LKE++        QL+ +G  +         S    S  E+L  RW 
Sbjct: 564  KELSVSVR-RLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWD 622

Query: 1685 LLQVAVEDRVRQLHEAHRDFG 1705
             L   +ED   Q+ +A    G
Sbjct: 623  SLVQRLEDSSNQVTQAVAKLG 643



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 82/467 (17%), Positives = 183/467 (39%), Gaps = 55/467 (11%)

Query: 13   YFLNAVRRQKLLEQSIQSA---QETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEA 69
            Y L   RR  L +Q   +    QE      ++      + K L  Y +D  D   + +  
Sbjct: 2360 YILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSD--DTRNVKETT 2417

Query: 70   QKIQSDLTSHEISLEEMKKHNQGK-EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQ 128
            + +++   + + S+ + +   + +    Q     ++   K +Q+      +    ++ E 
Sbjct: 2418 EYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHREN 2477

Query: 129  RLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQI 188
             LQ+S +          A E K   Q++ Q++++   +++KS+   + +  MV   G   
Sbjct: 2478 ALQDSIL----------ARELKQQMQDI-QAEIDAHNDIFKSIDGNRQK--MVKALGN-- 2522

Query: 189  VQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAA 248
                 +E    L  R+  +   +N+L AK    +  LE   +   ++   +  L +WL  
Sbjct: 2523 -----SEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNM 2577

Query: 249  TDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKK--ET 306
             D EL K+  + G    L  +    KA ++E+++++    S+    +  +  L  +  E 
Sbjct: 2578 KDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEY---SVLNAVDQARVFLADQPIEA 2634

Query: 307  LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT-KWIIQADTLLDESE 365
              E + +L +   +    RA++    + +    ++   ++++ +T  W  Q D  L+   
Sbjct: 2635 PEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALE--- 2691

Query: 366  KKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAA 425
              K +  +  +  L A++ +     +  +     L+ +  DH  K     I       A 
Sbjct: 2692 --KLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEK-----IMAFREEIAP 2744

Query: 426  ISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFN 472
            I+ ++KT              +D+   L PL+      ++ + +D N
Sbjct: 2745 INFKVKT-------------VNDLSSQLSPLDLHPSLKMSRQLDDLN 2778



 Score = 35.4 bits (80), Expect = 0.66
 Identities = 33/136 (24%), Positives = 61/136 (44%), Gaps = 4/136 (2%)

Query: 2157 LESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAE 2216
            ++ ++  E+++ L  LE+E R      D L Q  +   +       E +PT        +
Sbjct: 719  MKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQ---ILVEQMGKEGLPTEEIKNVLEK 775

Query: 2217 LIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTS 2276
            + +E K + QH   LE ++Q+ ED N   + QL  L ++++  +   K    + SS  + 
Sbjct: 776  VSSEWKNVSQHLEDLERKIQLQEDINAYFK-QLDELEKVIKTKEEWVKHTSISESSRQSL 834

Query: 2277 LQRSDSSQPMLLRVVG 2292
                DS Q  L  ++G
Sbjct: 835  PSLKDSCQRELTNLLG 850



 Score = 34.3 bits (77), Expect = 1.5
 Identities = 42/192 (21%), Positives = 74/192 (38%), Gaps = 15/192 (7%)

Query: 1513 ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV 1570
            +L  K+ +IM       +   +  ++ + ++   PR+   E  E A N+      Q+   
Sbjct: 236  QLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINI------QSTAP 289

Query: 1571 NTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSL 1630
              E E     +     ++D  L+     Q A +E+   L  AE        + D  ++ +
Sbjct: 290  EEEHESPRAETPSTVTEVDMDLD---SYQIALEEVLTWLLSAEDTFQEQDDISDD-VEEV 345

Query: 1631 QDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---LNTRWKLLQ 1687
            +D     +A   E+   + +V  V     QL T G           E    LN RW+ L+
Sbjct: 346  KDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALR 405

Query: 1688 VAVEDRVRQLHE 1699
            V   DR  +LH+
Sbjct: 406  VESMDRQSRLHD 417


>gi|5032297 dystrophin Dp71 isoform [Homo sapiens]
          Length = 617

 Score = 1240 bits (3208), Expect = 0.0
 Identities = 610/610 (100%), Positives = 610/610 (100%)

Query: 1735 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 1794
            HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8    HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67

Query: 1795 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 1854
            HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68   HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127

Query: 1855 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 1914
            VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128  VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187

Query: 1915 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 1974
            GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188  GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247

Query: 1975 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 2034
            CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248  CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307

Query: 2035 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 2094
            LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS
Sbjct: 308  LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 367

Query: 2095 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 2154
            RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL
Sbjct: 368  RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 427

Query: 2155 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 2214
            ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD
Sbjct: 428  ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 487

Query: 2215 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 2274
            AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS
Sbjct: 488  AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 547

Query: 2275 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT 2334
            TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT
Sbjct: 548  TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT 607

Query: 2335 PGKPMREDTM 2344
            PGKPMREDTM
Sbjct: 608  PGKPMREDTM 617



 Score = 35.0 bits (79), Expect = 0.87
 Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)

Query: 926  LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 981
            L ++  + G  L  + ISP E    E+ L Q   Q +     L + +      I  + ++
Sbjct: 376  LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 434

Query: 982  LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 1041
             G+LE+ L DLEE+  +L      ++ Q E         P ++  T      + P   E+
Sbjct: 435  RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 490

Query: 1042 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 1098
            +++ + L + K   +   + LED + + ++ ++RL Q L   Q +     TT+ +  T
Sbjct: 491  IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 548


>gi|5032299 dystrophin Dp71b isoform [Homo sapiens]
          Length = 635

 Score = 1214 bits (3142), Expect = 0.0
 Identities = 598/599 (99%), Positives = 598/599 (99%)

Query: 1735 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 1794
            HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8    HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67

Query: 1795 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 1854
            HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68   HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127

Query: 1855 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 1914
            VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128  VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187

Query: 1915 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 1974
            GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188  GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247

Query: 1975 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 2034
            CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248  CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307

Query: 2035 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 2094
            LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS
Sbjct: 308  LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 367

Query: 2095 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 2154
            RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL
Sbjct: 368  RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 427

Query: 2155 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 2214
            ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD
Sbjct: 428  ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 487

Query: 2215 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 2274
            AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS
Sbjct: 488  AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 547

Query: 2275 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRN 2333
            TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRG N
Sbjct: 548  TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHN 606



 Score = 35.0 bits (79), Expect = 0.87
 Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)

Query: 926  LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 981
            L ++  + G  L  + ISP E    E+ L Q   Q +     L + +      I  + ++
Sbjct: 376  LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 434

Query: 982  LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 1041
             G+LE+ L DLEE+  +L      ++ Q E         P ++  T      + P   E+
Sbjct: 435  RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 490

Query: 1042 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 1098
            +++ + L + K   +   + LED + + ++ ++RL Q L   Q +     TT+ +  T
Sbjct: 491  IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 548


>gi|5032301 dystrophin Dp71a isoform [Homo sapiens]
          Length = 604

 Score = 1203 bits (3112), Expect = 0.0
 Identities = 597/610 (97%), Positives = 597/610 (97%), Gaps = 13/610 (2%)

Query: 1735 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 1794
            HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8    HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67

Query: 1795 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 1854
            HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68   HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127

Query: 1855 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 1914
            VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128  VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187

Query: 1915 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 1974
            GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188  GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247

Query: 1975 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 2034
            CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248  CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307

Query: 2035 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 2094
            LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET             PASSPQLSHDDTHS
Sbjct: 308  LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET-------------PASSPQLSHDDTHS 354

Query: 2095 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 2154
            RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL
Sbjct: 355  RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 414

Query: 2155 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 2214
            ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD
Sbjct: 415  ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 474

Query: 2215 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 2274
            AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS
Sbjct: 475  AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 534

Query: 2275 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT 2334
            TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT
Sbjct: 535  TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT 594

Query: 2335 PGKPMREDTM 2344
            PGKPMREDTM
Sbjct: 595  PGKPMREDTM 604



 Score = 35.0 bits (79), Expect = 0.87
 Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)

Query: 926  LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 981
            L ++  + G  L  + ISP E    E+ L Q   Q +     L + +      I  + ++
Sbjct: 363  LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 421

Query: 982  LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 1041
             G+LE+ L DLEE+  +L      ++ Q E         P ++  T      + P   E+
Sbjct: 422  RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 477

Query: 1042 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 1098
            +++ + L + K   +   + LED + + ++ ++RL Q L   Q +     TT+ +  T
Sbjct: 478  IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 535


>gi|5032303 dystrophin Dp71ab isoform [Homo sapiens]
          Length = 622

 Score = 1177 bits (3046), Expect = 0.0
 Identities = 585/599 (97%), Positives = 585/599 (97%), Gaps = 13/599 (2%)

Query: 1735 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 1794
            HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8    HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67

Query: 1795 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 1854
            HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68   HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127

Query: 1855 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 1914
            VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128  VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187

Query: 1915 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 1974
            GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188  GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247

Query: 1975 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 2034
            CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248  CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307

Query: 2035 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 2094
            LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET             PASSPQLSHDDTHS
Sbjct: 308  LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET-------------PASSPQLSHDDTHS 354

Query: 2095 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 2154
            RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL
Sbjct: 355  RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 414

Query: 2155 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 2214
            ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD
Sbjct: 415  ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 474

Query: 2215 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 2274
            AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS
Sbjct: 475  AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 534

Query: 2275 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRN 2333
            TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRG N
Sbjct: 535  TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHN 593



 Score = 35.0 bits (79), Expect = 0.87
 Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)

Query: 926  LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 981
            L ++  + G  L  + ISP E    E+ L Q   Q +     L + +      I  + ++
Sbjct: 363  LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 421

Query: 982  LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 1041
             G+LE+ L DLEE+  +L      ++ Q E         P ++  T      + P   E+
Sbjct: 422  RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 477

Query: 1042 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 1098
            +++ + L + K   +   + LED + + ++ ++RL Q L   Q +     TT+ +  T
Sbjct: 478  IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 535


>gi|148539558 dystrophin related protein 2 [Homo sapiens]
          Length = 957

 Score =  996 bits (2574), Expect = 0.0
 Identities = 494/892 (55%), Positives = 651/892 (72%), Gaps = 27/892 (3%)

Query: 1441 MNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAV 1500
            MN  W+E++KKS N+R+ LEA SD   +L L LQE++ WL  KD+ELS Q P+ GD   V
Sbjct: 79   MNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVALV 138

Query: 1501 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 1560
            Q++ + H AF  E+K++ P I S LE+ + FL++ P E LE+ + E ++  P++R QN++
Sbjct: 139  QQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQNLS 198

Query: 1561 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 1620
            R + KQA   +  WEKL     D  R I+ TLE+L E+Q A +EL   L QAE ++ +W+
Sbjct: 199  RFVWKQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAEGVRATWE 258

Query: 1621 PVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLN 1680
            P+GDL IDSL +H++ +K  + E +P+K+ V  VNDLA QL    + LS  N   LE +N
Sbjct: 259  PIGDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAISDVHLSMENSQALEQIN 318

Query: 1681 TRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTT 1740
             RWK LQ +V +R++QL +AHRDFGP SQHFLS+SVQ PWERAISPNKVPYYINH+ QTT
Sbjct: 319  VRWKQLQASVSERLKQLQDAHRDFGPGSQHFLSSSVQVPWERAISPNKVPYYINHQAQTT 378

Query: 1741 CWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQN 1800
            CWDHPKMTELYQ+LADLNN++FSAYRTAMKLRR+QKAL LDL++L+ A +  ++H+L+ +
Sbjct: 379  CWDHPKMTELYQTLADLNNIKFSAYRTAMKLRRVQKALRLDLVTLTTALEIFNEHDLQAS 438

Query: 1801 DQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKT 1860
            +  MD++++I+CLT +Y+RLE+E   LVNVPLCVDM LNWLLNV+D+GR+G++R LSFKT
Sbjct: 439  EHVMDVVEVIHCLTALYERLEEERGILVNVPLCVDMSLNWLLNVFDSGRSGKMRALSFKT 498

Query: 1861 GIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEP 1920
            GI  LC   +++K +YLF QVA+S   CDQR LG+LLH++IQ+PRQLGEVA+FGGSN+EP
Sbjct: 499  GIACLCGTEVKEKLQYLFSQVANSGSQCDQRHLGVLLHEAIQVPRQLGEVAAFGGSNVEP 558

Query: 1921 SVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI 1980
            SVRSCF+F+  KP IEA+ FL+W+ LEPQSMVWL VLHRV  AE  KHQ KC+IC++CPI
Sbjct: 559  SVRSCFRFSTGKPVIEASQFLEWVNLEPQSMVWLAVLHRVTIAEQVKHQTKCSICRQCPI 618

Query: 1981 IGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFR 2040
             GFRYRSLK FN DICQ+CF +GR +KG+K+HYP++EY TPTTS E++RDFA  LKNKFR
Sbjct: 619  KGFRYRSLKQFNVDICQTCFLTGRASKGNKLHYPIMEYYTPTTSSENMRDFATTLKNKFR 678

Query: 2041 TKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYA 2100
            +K YF+KHP+ GYLPVQ+VLE D  ET             PASSP   H DTHSRIEH+A
Sbjct: 679  SKHYFSKHPQRGYLPVQSVLEADYSET-------------PASSPMWPHADTHSRIEHFA 725

Query: 2101 SRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLS--QPRSPAQILISLE 2158
            SRLAEME+ N S+ NDS+SP++SID++  L++H        SP++  +P    Q   S+ 
Sbjct: 726  SRLAEMESQNCSFFNDSLSPDDSIDEDQYLLRH-------SSPITDREPAFGQQAPCSVA 778

Query: 2159 SEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELI 2218
            +E +GEL++ILA LE+ENR LQ E  RLK QHE    +  PS  +    +    R+ EL+
Sbjct: 779  TESKGELQKILAHLEDENRILQGELRRLKWQHEE--AAEAPSLADGSTEAATDHRNEELL 836

Query: 2219 AEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQ 2278
            AEA++LRQHK RLE RMQILEDHNKQLESQL RLR+LL QP  E+  +G+  SS ++S Q
Sbjct: 837  AEARILRQHKSRLETRMQILEDHNKQLESQLQRLRELLLQPPTESDGSGSAGSSLASSPQ 896

Query: 2279 RSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSR 2330
            +S+ S P   R  G  T D+   +D+ S  QD S  LE++ME+L ++FPS R
Sbjct: 897  QSEGSHP---REKGQTTPDTEAADDVGSKSQDVSLCLEDIMEKLRHAFPSVR 945



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 54/235 (22%), Positives = 101/235 (42%), Gaps = 33/235 (14%)

Query: 1140 ELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNK 1199
            E+ DWLS  D+ + +Q  + GD+  + +      A M++++ R P +  ++ +AQ   ++
Sbjct: 113  EIIDWLSQKDEELSAQLPLQGDVALVQQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQ 172

Query: 1200 TSNQE-----ARTIITDRIERIQN--------------QWDEVQEHLQNRRQQLNEMLKD 1240
               +E     + +  T   +RIQN               W+++     ++ + +   L+ 
Sbjct: 173  HPFEELEEPHSESKDTSPKQRIQNLSRFVWKQATVASELWEKLTARCVDQHRHIERTLEQ 232

Query: 1241 STQWLEAKEEAEQVLGQARAKLESWKE-GPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 1299
              +   A EE    L QA     +W+  G   +D++ + I   K   ++    +  V + 
Sbjct: 233  LLEIQGAMEELSTTLSQAEGVRATWEPIGDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLV 292

Query: 1300 NDLALKLLRDYSADDTRKVHMITEN------INASWRSIHKRVSEREAALEETHR 1348
            NDLA +L           VH+  EN      IN  W+ +   VSER   L++ HR
Sbjct: 293  NDLAHQLA-------ISDVHLSMENSQALEQINVRWKQLQASVSERLKQLQDAHR 340



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 72/339 (21%), Positives = 132/339 (38%), Gaps = 51/339 (15%)

Query: 846  SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQ 903
            ++NL W E+ K+  + + RLE   +   + Q  L E + WL + D    A +PL+ G   
Sbjct: 78   AMNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQ-GDVA 136

Query: 904  QLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENK---------- 953
             ++++ E     +EE+  R   +  + E+    L   P    E+   E+K          
Sbjct: 137  LVQQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQN 196

Query: 954  -----LKQTNLQ---WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHL----LL 1001
                  KQ  +    W K++    ++   IE  ++ L +++  +E+L   L+        
Sbjct: 197  LSRFVWKQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAEGVRAT 256

Query: 1002 WLSPIRNQLEIYNQPNQEGPFDVQETEIA-----VQAKQPDVEEILSKGQHLYKEKPATQ 1056
            W  PI   L I + P       + + E +     V+       ++     HL  E     
Sbjct: 257  W-EPI-GDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAISDVHLSMEN---- 310

Query: 1057 PVKRKLEDLSSEWK----AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKE 1112
               + LE ++  WK    +V+  L++L+    D  PG     +S  Q         V  E
Sbjct: 311  --SQALEQINVRWKQLQASVSERLKQLQDAHRDFGPGSQHFLSSSVQ---------VPWE 359

Query: 1113 TAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQV 1151
             AIS  ++P  +  +       +   TEL   L+ L+ +
Sbjct: 360  RAISPNKVPYYINHQAQTTCWDHPKMTELYQTLADLNNI 398



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 35/174 (20%), Positives = 77/174 (44%), Gaps = 14/174 (8%)

Query: 206 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 265
           A+ L +NE+  K    + +LE     S K++  +  + +WL+  D EL+ +  ++G  + 
Sbjct: 78  AMNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVAL 137

Query: 266 LDSEVAWGKATQKEIEKQKVHLKSITEVGEAL----------KTVLGKKETLVEDKL-SL 314
           +  E     A  +E++ +  ++ S+ E  +A           +     K+T  + ++ +L
Sbjct: 138 VQQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQNL 197

Query: 315 LNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLLDESE 365
               W   T  +E W  L    ++  +H+E   + +  I   + +  T L ++E
Sbjct: 198 SRFVWKQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAE 251



 Score = 32.7 bits (73), Expect = 4.3
 Identities = 33/163 (20%), Positives = 73/163 (44%), Gaps = 21/163 (12%)

Query: 716 SKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIF 775
           SK T+  Q    + R   ++A    +  WEK+     D+    +R++E+       ++  
Sbjct: 185 SKDTSPKQRIQNLSRFVWKQATVASEL-WEKLTARCVDQHRHIERTLEQLLEIQGAMEEL 243

Query: 776 NQWLTEAEQFLRKT----------QIPENWEHAK-YKWYLKELQDGIGQRQTVVRTLNAT 824
           +  L++AE  +R T           +PE+ +  K +K     ++DG+     +   L  +
Sbjct: 244 STTLSQAEG-VRATWEPIGDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAIS 302

Query: 825 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEE 867
              +  ++S+         L  +N+RW+++   +S+R K+L++
Sbjct: 303 DVHLSMENSQA--------LEQINVRWKQLQASVSERLKQLQD 337


>gi|5032305 dystrophin Dp40 isoform [Homo sapiens]
          Length = 340

 Score =  693 bits (1789), Expect = 0.0
 Identities = 333/333 (100%), Positives = 333/333 (100%)

Query: 1735 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 1794
            HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8    HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67

Query: 1795 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 1854
            HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68   HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127

Query: 1855 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 1914
            VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128  VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187

Query: 1915 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 1974
            GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188  GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247

Query: 1975 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 2034
            CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248  CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307

Query: 2035 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET 2067
            LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET
Sbjct: 308  LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET 340


>gi|33188443 microfilament and actin filament cross-linker protein
            isoform b [Homo sapiens]
          Length = 5938

 Score =  251 bits (642), Expect = 5e-66
 Identities = 344/1741 (19%), Positives = 730/1741 (41%), Gaps = 207/1741 (11%)

Query: 17   AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEA---QKIQ 73
            A  RQK LE  +  A++  ++   I + L+  +K+LA         A++ Q+    + ++
Sbjct: 3876 AAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALE 3935

Query: 74   SDLTSHEISLEEMKKHNQG-----KEAAQRVLSQ-IDVAQKKLQDVSMKFRLFQKPANFE 127
             D+ +H   + +  K  Q        A Q VLS+ ID  Q +  ++  + R  +K A  +
Sbjct: 3936 EDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEI--QDRCCRKAALLD 3993

Query: 128  QRLQESKMI----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSE 177
            Q L  +++           L EV+  L ++  K  +Q+V+  Q    + L + +   K  
Sbjct: 3994 QALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKN 4053

Query: 178  VEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRK 237
            V+  IK G+ ++++   E    + E++  +K  Y ++    ++  + LE+  +L+ K + 
Sbjct: 4054 VDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQS 4113

Query: 238  EMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQ----KVHLKSITEV 293
                LT WL   + EL    A  G  S    ++   +  QKE++K+    ++ L ++ EV
Sbjct: 4114 TYEELTGWLREVEEEL----ATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEV 4169

Query: 294  GEALKTVLGKKETLVEDKL-SLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITK 352
              AL  ++  +     DKL S  N  +  V+    + ++ +    +  + ++Q  D    
Sbjct: 4170 SRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELA 4229

Query: 353  WIIQADTLLD-----ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDH 407
            W+ +    L        E+ +   +  V K    ++   +  +D      + +    G+ 
Sbjct: 4230 WVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEE 4289

Query: 408  CRKLVEPQISELNHRFAAIS-----HRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQ 462
             + +++ +   L  ++ AIS        +  +A + + +  +   ++   +E   A I Q
Sbjct: 4290 QKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ 4349

Query: 463  --GVNLKEEDFNKDMNE---------DNEGTVKELLQRGDNLQQRITDERKREEIKIKQQ 511
                 +  E   +   E         +++  + +LL+ G  L+     E   EE ++ ++
Sbjct: 4350 LPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLK-----ELNPEEGEMVEE 4404

Query: 512  LLQTKHNALKDLRSQRRKKALEI------SHQWYQYKRQADDLLKCLDDIEKKLASLPE- 564
              Q   N    ++ + R++AL +      S Q  ++  + + +L+ L+++  +L   P  
Sbjct: 4405 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 4464

Query: 565  PRDERKIKEIDR-------ELQKKKEELNAVRRQAE-------GLSEDGAAMAVEPTQIQ 610
            P +  KI+E          EL+K +    A++R+ E       G  +D AA  ++    Q
Sbjct: 4465 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQ 4524

Query: 611  LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 670
            +   W +I+++ A+ R + F  +  + E+              Y  +  LT I      +
Sbjct: 4525 MVFFWEDIKAR-AEEREIKFLDVLELAEKFW------------YDMAALLTTIKDTQDIV 4571

Query: 671  LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 730
             ++E     P +       + +Q E+ + IK+        ++ I       + +    E+
Sbjct: 4572 HDLESPGIDPSI-------IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEK 4624

Query: 731  VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ 790
             ++++++ +++  WE +NK +K+R  + + +++   ++   ++    WL      L  T 
Sbjct: 4625 PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLC-TM 4683

Query: 791  IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSS-KTDASILQEKLGS 846
             P   +    K  L E+++    + Q+Q  +  LN  GE ++++++ +TD  I++E L  
Sbjct: 4684 PPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTE 4743

Query: 847  LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI--ASIPLEPGKEQQ 904
            L   W+ + ++++ R+ +LE     L +FQ  L E + WL   + +  A  P+  G  + 
Sbjct: 4744 LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPIS-GDPKV 4802

Query: 905  LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKV 964
            ++ +L +  +L  ++   Q  ++ +N+ G  +L S+  + ++   L ++L+  N  W  V
Sbjct: 4803 IEVELAKHHVLKNDVLAHQATVETVNKAGNELLESS--AGDDASSLRSRLEAMNQCWESV 4860

Query: 965  SRALPEKQ--------------GEIEAQIKDLGQLEKKL----------EDLEEQLNHLL 1000
             +   E++               EIE  + +L ++E +L          E   EQL+  +
Sbjct: 4861 LQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHM 4920

Query: 1001 LWLSPIRNQLEIYNQPNQEGPFDV-QETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK 1059
               S ++ + E YNQ   +G   +    +    +K      +L +  H+   K   +  K
Sbjct: 4921 ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEER--K 4978

Query: 1060 RKLED---LSSEWK-------------------------AVNRLLQELRAKQP------- 1084
             KLE+   L++E++                          +N +L ++   +        
Sbjct: 4979 SKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNA 5038

Query: 1085 --DLAPGLTTIG-----ASPTQTVTLVTQPVVTKETAISK-----LEMPSSLMLEVPALA 1132
              D    L   G      S  Q V L+   +V+ ++   K     +E   SL        
Sbjct: 5039 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 5098

Query: 1133 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITA 1192
             F+ AW +L DWL   +  + S+  +  D + I   + K K   + L  ++P  +  I  
Sbjct: 5099 QFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRT 5158

Query: 1193 AQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 1252
             + LK KT   E    + + +  ++++WD V      R+ +L E L  S Q+++A +   
Sbjct: 5159 GRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALV 5218

Query: 1253 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 1312
              L +   +L   +     +D +   +   K   K+L +    V V      +L+ + S 
Sbjct: 5219 DWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-SR 5277

Query: 1313 DDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT-- 1370
            DDT  V    + ++  W ++ K    +++ LE+  +  + F   +   L WL+EAE T  
Sbjct: 5278 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 5337

Query: 1371 -ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 1429
                L D T   + L D+   KE MK+ ++ + ++ +   +         +++ ++   D
Sbjct: 5338 FRGALPDDTEALQSLIDTH--KEFMKKVEEKRVDVNSAVAM--------GEVILAVCHPD 5387

Query: 1430 DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR 1489
                ++  +  +  ++ E+   +   +  LE +  +       L+ELL W+Q  +  L +
Sbjct: 5388 CITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQ 5447

Query: 1490 --QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVI--------MSTLETVRIFLTEQPLEG 1539
              Q PI  +   V+     H+ F  E+  K+P +           +E       E+   G
Sbjct: 5448 RDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSG 5507

Query: 1540 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 1599
              K   +P   PP     + +     +  +++  W+++ L + + QRK+++ L+RL+EL+
Sbjct: 5508 GRKSLSQP--TPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELK 5565

Query: 1600 E 1600
            E
Sbjct: 5566 E 5566



 Score =  249 bits (635), Expect = 3e-65
 Identities = 337/1747 (19%), Positives = 735/1747 (42%), Gaps = 180/1747 (10%)

Query: 19   RRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLA---AYIADKVDAAQMPQEAQK---- 71
            R+ K L  +  +A+E E    ++   +  I++QLA    +  ++VD  QM  +       
Sbjct: 3675 RKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQ 3734

Query: 72   --IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQK 122
              IQS     D+   E  +EE+    +   K+ AQR+         +LQ+  +       
Sbjct: 3735 GLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA--------QLQEALLHC----- 3781

Query: 123  PANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 182
               F+  L+     L + +  +   +  S E +VV++Q+     L + L + K+ V+M+ 
Sbjct: 3782 -GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3840

Query: 183  KTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVL 242
              G +I Q  +  + +++  ++ +L+  + EL +K   R++QLE  L L+++  +    +
Sbjct: 3841 AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPI 3900

Query: 243  TEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 302
            +++L+ T+ +L     V    + +  ++   KA +++IE     +    ++G++L ++  
Sbjct: 3901 SDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTS 3960

Query: 303  KKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL 361
              E  ++ +K+  L + +  +  R      LL +   +   F ++   +  W+ + +  L
Sbjct: 3961 PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKL 4020

Query: 362  DESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEP 414
                 K    K+DVL R       L  E+ + +  VD        L+         L++ 
Sbjct: 4021 SSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQE 4078

Query: 415  QISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKD 474
            ++  +  R+A I+  + + KA   L++  Q  +  Q   E L   +++   ++EE     
Sbjct: 4079 KLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYEELTGWLRE---VEEELATSG 4133

Query: 475  MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALE- 533
                    + +  QR   L++ + + R      +    +     AL +L   R ++ L+ 
Sbjct: 4134 GQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVNEVSRALLELVPWRAREGLDK 4187

Query: 534  -ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDREL------QKKKEELN 586
             +S    QYK  +D + + +D+I+  +      R ++  +  D EL      ++K   L 
Sbjct: 4188 LVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQAADAELAWVAETKRKLMALG 4242

Query: 587  AVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ----FRRLNFAQIHTVREETM 641
             +R + +   +  A + V+    I + +    ++  F+     F      Q   ++E+T 
Sbjct: 4243 PIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTE 4299

Query: 642  MVMTEDMPLEI------------SYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 689
             ++ +   + +              + + +      +S  + E   L+      A D E 
Sbjct: 4300 SLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQ 4359

Query: 690  LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 749
            L +Q+E ++ +++S+ +    ID +  K    L+   P E   ++E   + +  + ++ +
Sbjct: 4360 LRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKE 4418

Query: 750  MYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFLRKTQ-IPENWEHAKYKWYLK 805
              + R    D +V +  +   FH  I+   + L      LR    IP   E  K +  + 
Sbjct: 4419 EVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPA--EVDKIRECIS 4476

Query: 806  ELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQL 858
            + +     + + Q     L   GEE+I +S   D  +    +Q+KL  +   W+++  + 
Sbjct: 4477 DNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARA 4536

Query: 859  SDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVE 917
             +R+ +  +   +  +F  D+   +  +++  +I      PG +  + K+++E  + + E
Sbjct: 4537 EEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4596

Query: 918  ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 977
            E       L+ +   G  ++ +      E+ ++   + + N  W  +++   E+  ++E 
Sbjct: 4597 ETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4654

Query: 978  QIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAK 1034
             ++   Q +  L+ + + L++ ++ L    P+   L        E    ++E ++ V  +
Sbjct: 4655 AMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE----MKEFKVEVYQQ 4710

Query: 1035 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 1094
            Q ++E++  +G+ + K+  AT    R +         +   L EL+    +L        
Sbjct: 4711 QIEMEKLNHQGELMLKK--ATDETDRDI---------IREPLTELKHLWENLG------- 4752

Query: 1095 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 1154
                            ++ A  + ++  +L+    AL  F  A  EL  WL+  ++++ +
Sbjct: 4753 ----------------EKIAHRQHKLEGALL----ALGQFQHALEELMSWLTHTEELLDA 4792

Query: 1155 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 1214
            QR + GD + I   + K      D+   +  +E +  A   L   ++  +A + +  R+E
Sbjct: 4793 QRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASS-LRSRLE 4851

Query: 1215 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 1274
             +   W+ V +  + R QQL   L+ +  +    E+    L +  ++L + K      + 
Sbjct: 4852 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPET 4911

Query: 1275 IQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1333
             ++++    +L   L+ + +T   + +   L LL    +    K       +   W  + 
Sbjct: 4912 AREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVS 4971

Query: 1334 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1393
             ++ ER++ LEE   L  +F   L++F+ WLT AE + N+   A+    +L     V   
Sbjct: 4972 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI---ASPPSLILNT---VLSQ 5025

Query: 1394 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1453
            +++ +    E+ AH D    LD+   + L+ L    D VL++  L ++  +W ++ ++S+
Sbjct: 5026 IEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI 5084

Query: 1454 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1513
                 L+ +  + K+ H + ++L+ WL+  +  L  +  I  D   ++ Q   H+ F++ 
Sbjct: 5085 ERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKT 5144

Query: 1514 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1573
            L  K+PV  +T+ T R                + + L PE+ +Q +   L     EV  +
Sbjct: 5145 LGGKQPVYDTTIRTGRAL--------------KEKTLLPED-SQKLDNFL----GEVRDK 5185

Query: 1574 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQD 1632
            W+ +   S + Q K++E L    +  +A   L   L + E      QPV GDL  D + +
Sbjct: 5186 WDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDL--DLVMN 5243

Query: 1633 HLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKL---LQVA 1689
             ++  K  + E+      V  +    R+L       + +    L++L+TRW     L V+
Sbjct: 5244 LMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVS 5303

Query: 1690 VEDRVRQ 1696
             + R+ Q
Sbjct: 5304 KQSRLEQ 5310



 Score =  211 bits (538), Expect = 5e-54
 Identities = 284/1603 (17%), Positives = 653/1603 (40%), Gaps = 161/1603 (10%)

Query: 99   VLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQ 158
            +LS+    QK+L+D+ +  + F + A      +     L   +  L   E    +   +Q
Sbjct: 3872 LLSKAAARQKQLEDILVLAKQFHETA------EPISDFLSVTEKKLANSEPVGTQTAKIQ 3925

Query: 159  SQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKV 218
             Q+     L + +    ++V   +K G+ +           L E++ +L+  Y+E+  + 
Sbjct: 3926 QQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC 3985

Query: 219  TERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQK 278
              +   L++ L  +R   ++   +  WLA  + +L+     +     L  + A   A  +
Sbjct: 3986 CRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNE 4045

Query: 279  EIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 337
            EI  +K ++    + G+AL K   G++  L+++KL  + + +  +T  + + L  L + +
Sbjct: 4046 EIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQAR 4105

Query: 338  KHMETFDQNVDHITKWIIQADTLLDESEKKKPQ-----QKEDVLKRLKAELNDIRPKVDS 392
            +    F    + +T W+ + +  L  S  + P      Q +   K LK E+ + R  +D+
Sbjct: 4106 QLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDT 4165

Query: 393  TRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI--KTGKASIPLKELEQF----N 446
              + +  L+       R+ ++  +S+ N ++  +S  I  +  +    ++  +Q+    +
Sbjct: 4166 VNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAAD 4225

Query: 447  SDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD------- 499
            +++  + E     +  G    E+D      +  +    ++++  D++ +  +        
Sbjct: 4226 AELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT 4285

Query: 500  --ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 557
              E ++  ++ K + L  ++ A+  L S+R  +         Q+    ++L   +++   
Sbjct: 4286 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 4345

Query: 558  KLASLPEPR-DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA-VEPTQIQL-SKR 614
             +A LP P  D  ++++   E+++ +E +   +   + L + G  +  + P + ++  ++
Sbjct: 4346 LIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEK 4405

Query: 615  WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVE 674
            +++ E+ +AQ           ++EE   V    + L+ +   ST +TE     + +LE  
Sbjct: 4406 YQKAENMYAQ-----------IKEE---VRQRALALDEAVSQSTQITEFHDKIEPMLETL 4451

Query: 675  QLLNA----PDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 730
            + L++    P L   + + + +     K+    L++     + +  +    +  +   ++
Sbjct: 4452 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4511

Query: 731  ----VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL 786
                 ++Q+ L Q+ F WE +    ++R+ +F   +E   +F YD+      + + +  +
Sbjct: 4512 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4571

Query: 787  RKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDAS 838
               + P        +  E A+    +KE  DG+ +    +R L   G ++I    +T+  
Sbjct: 4572 HDLESPGIDPSIIKQQVEAAET---IKEETDGLHEELEFIRIL---GADLIFACGETEKP 4625

Query: 839  ILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPL 897
             +++ +  +N  W+ + K   +R ++LE+      ++Q  L     WL+     + ++P 
Sbjct: 4626 EVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4685

Query: 898  EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 957
                   +K++L ++K    E+  +Q  +++LN  G  +L  A     ++D +   L + 
Sbjct: 4686 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKAT-DETDRDIIREPLTEL 4744

Query: 958  NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 1017
               W  +   +  +Q ++E  +  LGQ +  LE+L       + WL+     L+   Q  
Sbjct: 4745 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEEL-------MSWLTHTEELLDA--QRP 4795

Query: 1018 QEGPFDVQETEIA--------VQAKQPDVEEILSKGQHLYKEKPA--TQPVKRKLEDLSS 1067
              G   V E E+A        V A Q  VE +   G  L +         ++ +LE ++ 
Sbjct: 4796 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQ 4855

Query: 1068 EWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 1127
             W++V   LQ+   ++  L   L       ++           ++  +    M S L   
Sbjct: 4856 CWESV---LQKTEEREQQLQSTLQQAQGFHSEI----------EDFLLELTRMESQLSAS 4902

Query: 1128 VPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE 1187
             P       A  +L   + L  Q+   +       E  N+++ K +  +           
Sbjct: 4903 KPTGGLPETAREQLDTHMELYSQLKAKE-------ETYNQLLDKGRLML----------- 4944

Query: 1188 ELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEA 1247
                    L    S   ++T     +  ++ +W  V   ++ R+ +L E L  +T++  +
Sbjct: 4945 --------LSRDDSGSGSKT--EQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNS 4994

Query: 1248 KEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL 1307
             +E    L  A   L         ++ +  +I E K  A ++   +  +   +    +L 
Sbjct: 4995 LQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLK 5054

Query: 1308 RDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEA 1367
                  D   +  +  ++ + W  + +R  ER  +L++  +  +QF    +K + WL +A
Sbjct: 5055 FLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDA 5114

Query: 1368 ETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG 1427
            E+  +       +  +  D   +K  + + ++ Q  +     VY       + +      
Sbjct: 5115 ESHLD------SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLL 5168

Query: 1428 SDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 1487
             +D+  L   L  +  KW  +  KS+  +  LE +     +   +LQ L+ WL   + +L
Sbjct: 5169 PEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQL 5228

Query: 1488 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 1547
            +   P+ GD   V    D H+ F++EL  +   +                   + L +  
Sbjct: 5229 AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTV-------------------QVLKRSG 5269

Query: 1548 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDL 1607
            REL   E +++ T  ++ Q +E++T W+ +   S   Q ++++ L++ +  ++    L  
Sbjct: 5270 RELI--ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 5327

Query: 1608 KLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVKALRGEI 1644
             L +AE        + D       LID+ ++ ++KV+  R ++
Sbjct: 5328 WLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDV 5370



 Score =  209 bits (531), Expect = 3e-53
 Identities = 336/1819 (18%), Positives = 737/1819 (40%), Gaps = 202/1819 (11%)

Query: 24   LEQSIQSAQETEKSLHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEI 81
            LE+  Q  +E ++S   I++ +     QL  +  +  +  + +  ++ +  Q  L + E 
Sbjct: 3445 LEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3504

Query: 82   SLEEMKKHNQGK-------EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANF 126
             ++ ++   QG          A ++L Q +VAQ++  +V  +            +    F
Sbjct: 3505 QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQF 3564

Query: 127  EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 186
              R++E    L ++   L  +     + + +QSQ+         +  +K ++E      R
Sbjct: 3565 HCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECR 3624

Query: 187  QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 246
             +++++ T +   L   + AL     +L  +   R++QLE  L       +++  L +  
Sbjct: 3625 HMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDAT 3684

Query: 247  AATDMELTKRSAVEGMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKE 305
             A +     +  V      ++ ++A  K  QKE ++  ++ L+ +  +G+ L    GK  
Sbjct: 3685 TAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDC 3744

Query: 306  TL--VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDE 363
             +  +E  +  +N+ W  +  +  + +  L E   H   F   ++ +  W+   + L+  
Sbjct: 3745 DVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-- 3802

Query: 364  SEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI 416
            + +K P  +  V+K        L+  L+D +  VD  + +   +  +     R+ +  Q+
Sbjct: 3803 ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQL 3862

Query: 417  SELNHRFAAISHRIKTGKASIPLKELEQ-----------------FNSDIQKLL---EPL 456
              L  R+  +       KA+   K+LE                  F S  +K L   EP+
Sbjct: 3863 ESLESRWTEL-----LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3917

Query: 457  ---EAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLL 513
                A+IQQ + ++ +   +D+ E++   V + ++ G +L   +T   ++  +  K   L
Sbjct: 3918 GTQTAKIQQQI-IRHKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSL 3974

Query: 514  QTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKE 573
            Q +++ ++D   ++     +       +     ++L  L ++E KL+S+        +K+
Sbjct: 3975 QARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKD 4027

Query: 574  IDRELQKKK--------EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQF 625
              +++  ++        EE+   ++  +   ++G A+  + T  ++     +++      
Sbjct: 4028 FKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI---- 4083

Query: 626  RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 685
             +  +A I     + +  + +   L   +  STY      ++  L EVE+ L      + 
Sbjct: 4084 -KTRYADITVTSSKALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSP 4137

Query: 686  DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 745
              E + + ++  K +K  + +    +D ++    A L+      R  L + +S  + Q++
Sbjct: 4138 TGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYK 4197

Query: 746  KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKW 802
             V+     R    D ++++ +++         W+ E ++ L      ++ ++   A+ + 
Sbjct: 4198 LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ- 4256

Query: 803  YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 862
              K     I + +  +  L +   EI     +   ++LQEK  SL  +++ +    S+R 
Sbjct: 4257 VQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERY 4316

Query: 863  KRLEEQKNILSEFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPL 921
             RLE  + ++++F     E   W+EE    IA +P      +QL+++ E+++ L E +  
Sbjct: 4317 ARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAE 4376

Query: 922  RQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQ 978
             +  + +L + G  +     ++PEE + +E K ++    + ++   + ++     E  +Q
Sbjct: 4377 HKPHIDKLLKIGPQL---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQ 4433

Query: 979  IKDLGQLEKKLEDLEEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQ 1032
               + +   K+E + E L +L   L + P+     +++      N+    ++++ + + +
Sbjct: 4434 STQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFE 4493

Query: 1033 AKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK---------- 1082
            A +   EE++ + Q   K+  A + ++ KL+ +   W+ +    +E   K          
Sbjct: 4494 ALKRRGEELIGRSQGADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEK 4552

Query: 1083 -QPDLAPGLTTIG---------ASPTQTVTLVTQPVVTKETA------------------ 1114
               D+A  LTTI           SP    +++ Q V   ET                   
Sbjct: 4553 FWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILG 4612

Query: 1115 ---------ISKLEMPSSLMLEVPALADFNRAWTE---------------------LTDW 1144
                       K E+  S+     A  + N+ W E                     + DW
Sbjct: 4613 ADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDW 4672

Query: 1145 LSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE 1204
            L      + +   +  DL  + + + + K    ++ Q++ ++E+L    + +  K +++ 
Sbjct: 4673 LDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDET 4732

Query: 1205 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLES 1264
             R II + +  +++ W+ + E + +R+ +L   L    Q+  A EE    L      L++
Sbjct: 4733 DRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDA 4792

Query: 1265 WKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITEN 1324
             +        I+ ++ +   L  D+   Q  V+  N    +LL   + DD   +    E 
Sbjct: 4793 QRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEA 4852

Query: 1325 INASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLL 1384
            +N  W S+ ++  ERE  L+ T +  Q F  ++E FL  LT  E+  +    A++    L
Sbjct: 4853 MNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGL 4908

Query: 1385 EDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFK 1444
             ++   +E +    +L  +++A  + Y+ L +  + +L S + S      ++ +  +  K
Sbjct: 4909 PET--AREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQK 4966

Query: 1445 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQN 1504
            W  +  K    +S LE + +       SLQE + WL L +  L+  +P       V  Q 
Sbjct: 4967 WHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI 5026

Query: 1505 DVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR 1564
            + H+ F  E+      I+                   +L Q   +L    + Q+V  L++
Sbjct: 5027 EEHKVFANEVNAHRDQII-------------------ELDQTGNQLKFLSQKQDVV-LIK 5066

Query: 1565 KQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG- 1623
                 V + WEK+   S +  R +D+  +R ++  EA  +L   L  AE    S   +  
Sbjct: 5067 NLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 5126

Query: 1624 --DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNT 1681
              D +   L  H E  K L G+  P+ +         ++ T L       + + L ++  
Sbjct: 5127 DPDKIKLQLSKHKEFQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRD 5184

Query: 1682 RWKLLQVAVEDRVRQLHEA 1700
            +W  +     +R  +L EA
Sbjct: 5185 KWDTVCGKSVERQHKLEEA 5203



 Score =  155 bits (393), Expect = 3e-37
 Identities = 297/1513 (19%), Positives = 615/1513 (40%), Gaps = 181/1513 (11%)

Query: 148  ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENP--KELDERVT 205
            +T + +  V+Q QL     L + L+E +  VE + K  R I++ +    P  + + E   
Sbjct: 2463 DTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTD 2522

Query: 206  ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 265
            ++  H+  L   + ER   L+K +  S+ +++ +  L + +   +  L  +         
Sbjct: 2523 SILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGV 2582

Query: 266  LDSEVAWGKATQKEIEKQKVHLKSITE-VGEALKTVLGKKETLVEDKLSLLN-------- 316
            +   +A     +++I +QK  L++  E V   ++T       +++ KL+ ++        
Sbjct: 2583 IQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCL 2642

Query: 317  ------SNWIAVTSRAEEWLNLLLEYQKHMETF----------DQNVDHITKWIIQADTL 360
                  S+   +  +AE + +L  + Q+ ME            DQ++ H  + I + +  
Sbjct: 2643 QQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNL- 2701

Query: 361  LDESEKKKPQQKEDVLKRLKAELNDIRPKVD--STRDQAANLMANRGDHCRKLVE----- 413
                E +  Q+  D L+ L  EL+     +D    +D+  NL  +  +  + + E     
Sbjct: 2702 ----EMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDA 2757

Query: 414  ----PQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA---------EI 460
                 Q+ E           +K  + SIP  E      +++K +E L++          +
Sbjct: 2758 SSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL 2817

Query: 461  QQGVNLKEEDFNKDMNE----DNEGTVKELLQRGDNLQQRITDE---RKREEIKIKQQLL 513
             + +N K       + E    D++G    +L    +    +      +   EI+     +
Sbjct: 2818 VEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDV 2877

Query: 514  QTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKE 573
              K+  L  +  +R++    I ++  +  ++A+ +L+ L+  E+ L S+       K + 
Sbjct: 2878 NLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTET 2937

Query: 574  IDRELQKKK---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKF-AQFRRLN 629
            +  + +  K    EL     + + + E  A + V     Q ++ W++I+ +  +++ R  
Sbjct: 2938 VKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERAT 2997

Query: 630  FAQIHTVR--EETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVE-QLLNAP----DL 682
               +   R  EE+   +      E    P     E+       L ++  +LNA       
Sbjct: 2998 EVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQF 3057

Query: 683  CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDF 742
              K+FE   +Q E L      +    G + +  S+    LQS    + V+L + L+    
Sbjct: 3058 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQ-KWVELTDKLNSRSS 3116

Query: 743  QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKW 802
            Q ++        Q       EK R     + + +   T+ E   ++ +     E ++ + 
Sbjct: 3117 QIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLE-----ETSEIRS 3171

Query: 803  YLKELQDGIGQRQTVVRTLNA-TGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDR 861
             L++L   + + QT+   L+   GE+ ++         L+++L ++ L  Q +    +DR
Sbjct: 3172 DLEQLDHEVKEAQTLCDELSVLIGEQYLKDE-------LKKRLETVALPLQGLEDLAADR 3224

Query: 862  KKRLEEQKNILSEFQRDLNEFVLWLE--EADNIASIPLEPGKEQQLKEKLEQVKLLVEEL 919
              RL+       +FQ+  +E   WL+  ++    + P+   K ++L+ +L++ +   + L
Sbjct: 3225 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPIS-AKLERLQSQLQENEEFQKSL 3283

Query: 920  PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 979
                G  + +   G  +L+S P   EE+  L+N+L +    W ++S+   ++Q    +++
Sbjct: 3284 NQHSGSYEVIVAEGESLLLSVP-PGEEKRTLQNQLVELKNHWEELSKKTADRQ----SRL 3338

Query: 980  KDLGQLEKK-----------LEDLEEQLNHLLLWLSPI-------------------RNQ 1009
            KD  Q  +K           +ED + +++ L + L P+                   R+ 
Sbjct: 3339 KDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSL 3398

Query: 1010 LEIYN----------QPNQEGPFD----VQETEIAV----QAKQPDVEEI---LSKGQHL 1048
            LEI N          + +++G  D    + +   AV    QAK   +EE+   L + Q  
Sbjct: 3399 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 3458

Query: 1049 YKE-KPATQPVKRKLE--DLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 1105
            +K  +   +  K +LE  D        N+ L++LRA+Q  L      +      T  LV 
Sbjct: 3459 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3518

Query: 1106 QPVVTKETA--ISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLE 1163
                  + +  + + E+     LEV      N     + + L  + Q     R M   L 
Sbjct: 3519 DAPDGSDASQLLHQAEVAQQEFLEVKQRV--NSGCVMMENKLEGIGQFHCRVREMFSQLA 3576

Query: 1164 DINEMIIKQKATMQDLEQRRPQLEELITAAQ-----NLKNKTSNQEARTIITD------- 1211
            D+++ +    A  +D +  + Q+E++           L  + S  E R ++ +       
Sbjct: 3577 DLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLL 3636

Query: 1212 ----RIERIQNQWDEVQEHLQNRRQQLNEML---KDSTQWLEAKEEAEQVLGQARAKLES 1264
                 +E +  Q  ++ E  + R++QL   L   +D  + L+   +A     +A A    
Sbjct: 3637 GLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEAL--Q 3694

Query: 1265 WKEGPYTVDAIQKKITETKQLAKD-LRQWQTNVDVANDLALKLLRDYSAD-DTRKVHMIT 1322
            W  G   V+ I +++ + K   K+ +   Q  +   N L   L++    D D + +    
Sbjct: 3695 WVVGT-EVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDM 3753

Query: 1323 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1382
            E INA W +++K+V++R A L+E      +F   LE  L+WL + E        A +K  
Sbjct: 3754 EEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-----ANQKPP 3808

Query: 1383 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1442
              E  K VK  +++ + LQ  ++        L     +I +S E + D   +  +L+++ 
Sbjct: 3809 SAE-YKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA-DREKITGQLESLE 3866

Query: 1443 FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQK 1502
             +W+EL  K+   +  LE      K+ H + + +  +L + + +L+   P+G     +Q+
Sbjct: 3867 SRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ 3926

Query: 1503 QNDVHRAFKRELK 1515
            Q   H+A + +++
Sbjct: 3927 QIIRHKALEEDIE 3939



 Score =  139 bits (349), Expect = 4e-32
 Identities = 282/1654 (17%), Positives = 682/1654 (41%), Gaps = 187/1654 (11%)

Query: 107  QKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVN 166
            Q+ LQ +  +     K AN   +  ESK   +EV   + A+ + + + E V++Q      
Sbjct: 2892 QESLQAILNRMEEVHKEANSVLQWLESK---EEVLKSMDAMSSPT-KTETVKAQAESNKA 2947

Query: 167  LYKSLSEVKSEVEMVIKTGRQIV----QKKQTENPKELDERVTALKLHYNELGAKVTERK 222
                L +   +++ V +    ++      ++ EN K++ E + +      E+      R+
Sbjct: 2948 FLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEV---TVARQ 3004

Query: 223  QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 282
            +QLE+        +   + L  WL   ++ +     +   P+ L+++    +   KE E 
Sbjct: 3005 RQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEA 3064

Query: 283  QKVHLKSITEVGEALKTVLGK---KETLVEDKLSLLNSNWIAVT-------SRAEEWLNL 332
            ++   + + E  + + T  G      + V+ +L  +N  W+ +T       S+ ++ +  
Sbjct: 3065 RRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVK 3124

Query: 333  LLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDS 392
              +YQ+ ++   + V  + + +     +  + E  K Q +E     ++++L  +  +V  
Sbjct: 3125 STQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEET--SEIRSDLEQLDHEVKE 3182

Query: 393  TRDQAANLMANRG-----DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFN 446
             +     L    G     D  +K +E     L       + RI   +A++   ++ +Q  
Sbjct: 3183 AQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMF 3242

Query: 447  SDIQKLLE----------PLEAEIQ--QGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ 494
             +++  L+          P+ A+++  Q    + E+F K +N+ + G+ + ++  G++L 
Sbjct: 3243 DELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQ-HSGSYEVIVAEGESLL 3301

Query: 495  QRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDD 554
              +    ++  ++ +   L+     L    + R+ +  +   +  +Y+   +DL+  ++D
Sbjct: 3302 LSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED 3361

Query: 555  IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKR 614
             + K++ L    D     +++  L + K  LN V ++   L    +A  +     +  + 
Sbjct: 3362 CKAKMSELRVTLDP---VQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED 3418

Query: 615  WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL--LE 672
               I  + A   +   A    ++ +T  +  E+M   +     ++      V  A   LE
Sbjct: 3419 G--IRDEKAGINQNMDAVTEELQAKTGSL--EEMTQRLREFQESFKNIEKKVEGAKHQLE 3474

Query: 673  VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA---TPVE 729
            +   L +     K+ E L  Q+E L+ ++        ++D + +     ++ A   +   
Sbjct: 3475 IFDALGSQACSNKNLEKLRAQQEVLQALEP-------QVDYLRNFTQGLVEDAPDGSDAS 3527

Query: 730  RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIK-IFNQWLTEAEQFLRK 788
            ++  Q  ++Q +F   +V +         +  +E   +FH  ++ +F+Q     ++    
Sbjct: 3528 QLLHQAEVAQQEFL--EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGM 3585

Query: 789  TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEE---IIQQSSKTDASILQEKLG 845
              I  + +  + +  +++++  + +   +   + A+  E   ++++    D   L+ +L 
Sbjct: 3586 GAIGRDTDSLQSQ--IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELE 3643

Query: 846  SLNLRWQEVCKQLSDRKKRLEEQKNI----LSEFQRDL---NEFVLWLEEADNIASIPLE 898
            +LN +    C +L++R K  +EQ  +    + +F R L   N+     EEA+ +  +   
Sbjct: 3644 ALNKQ----CGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVV-- 3697

Query: 899  PGKEQQL-KEKLEQVKLLVEEL--PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLK 955
             G E ++  ++L   K+  +E   PL+   L+Q+N  G  ++ SA    + Q  LE+ ++
Sbjct: 3698 -GTEVEIINQQLADFKMFQKEQVDPLQMK-LQQVNGLGQGLIQSAGKDCDVQG-LEHDME 3754

Query: 956  QTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQ 1015
            + N +W  +++ + ++  +++  +   G+ +  LE L       L WL+     +     
Sbjct: 3755 EINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPL-------LSWLADTEELIANQKP 3807

Query: 1016 PNQEGPF---DVQETEIA---VQAKQPDVEEILSKGQHLYK--EKPATQPVKRKLEDLSS 1067
            P+ E       +QE ++    +  ++  V+ + ++G  + +  E    + +  +LE L S
Sbjct: 3808 PSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLES 3867

Query: 1068 EWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 1127
             W     LL +  A+Q  L   L                 V+ K+               
Sbjct: 3868 RW---TELLSKAAARQKQLEDIL-----------------VLAKQ--------------- 3892

Query: 1128 VPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE 1187
                  F+     ++D+LS+ ++ + +   +      I + II+ KA  +D+E     + 
Sbjct: 3893 ------FHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVH 3946

Query: 1188 ELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEA 1247
            + +   Q+L + TS  E + +++++I+ +Q ++ E+Q+    +   L++ L ++  + E 
Sbjct: 3947 QAVKIGQSLSSLTSPAE-QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED 4005

Query: 1248 KEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL 1307
            + E    L +   KL S     +  D + ++  +   L +++   + NVD A      LL
Sbjct: 4006 EVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALL 4065

Query: 1308 RDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEA 1367
            +  + ++   +    + I   +  I    S+    LE+  +L  +F    E+   WL E 
Sbjct: 4066 KQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREV 4125

Query: 1368 ETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL----- 1422
            E      ++           + + +  ++ ++L+ E+  H  V   ++E S+ +L     
Sbjct: 4126 E------EELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPW 4179

Query: 1423 RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL 1482
            R+ EG D  V       + N ++  +          ++A+  + ++   +    L W+  
Sbjct: 4180 RAREGLDKLV------SDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAE 4233

Query: 1483 KDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEK 1542
               +L    PI  +      Q  V +AF             +++ +R        + +++
Sbjct: 4234 TKRKLMALGPIRLEQDQTTAQLQVQKAF-------------SIDIIR------HKDSMDE 4274

Query: 1543 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 1602
            L+    E+      +  T +L+++ E +  ++E ++L +++   +++     + +  E  
Sbjct: 4275 LFSHRSEIFGTCGEEQKT-VLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETY 4333

Query: 1603 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 1662
            +EL   + +   +     P   +  + L+   E+++ LR  IA  K ++  +  +  QL 
Sbjct: 4334 EELSPWIEETRALIAQ-LPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLK 4392

Query: 1663 TLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 1696
                +L+P     +E+   + + +   +++ VRQ
Sbjct: 4393 ----ELNPEEGEMVEEKYQKAENMYAQIKEEVRQ 4422



 Score =  120 bits (300), Expect = 2e-26
 Identities = 252/1367 (18%), Positives = 508/1367 (37%), Gaps = 188/1367 (13%)

Query: 434  KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 493
            +A +  +EL+   + + + LE +   I            K + +D +   K L    D  
Sbjct: 1843 QAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTW 1902

Query: 494  QQRITDERKREEIKIKQQLLQTKH--NALKDLRSQRRKKALEISHQWYQYKRQADDLLKC 551
              R+   +   EI+  + L Q       L+DLR+    K L ++ +    +   D L  C
Sbjct: 1903 NSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLC 1962

Query: 552  LDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQL 611
            L   E     L +P  ERK             +L+A+    +    + A         Q+
Sbjct: 1963 LQQYE----DLKQPMAERKA------------QLDALAFDIQFFISEHAQDLSPQQNRQM 2006

Query: 612  SKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 671
             +   E++  F        AQ+  ++     +  E +   +    +T   ++  +   + 
Sbjct: 2007 LRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVG 2066

Query: 672  EVEQLLNAPD--LCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQS----A 725
            + E+ L         +D   L K +  LK+++D +Q  +     +       ++      
Sbjct: 2067 QAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKL 2126

Query: 726  TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYD-------------- 771
            +P E   L+E L Q   Q+E + +  +  Q   + +V    +   +              
Sbjct: 2127 SPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKK 2186

Query: 772  IKIFNQWLTEA------------------------------EQFLRKTQIPENWEH---- 797
            I     W+T                                + ++   Q PE  +     
Sbjct: 2187 IDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEM 2246

Query: 798  --AKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC 855
              A+++  L + Q+ I   Q+    L+  G  +  +  +    +LQ+KLG L  ++    
Sbjct: 2247 MKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQ----MLQQKLGELKEQYSTSL 2302

Query: 856  KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKL 914
             Q     K+++  ++ L +F +D  EF  WLE ++  + ++       + L   L++   
Sbjct: 2303 AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGS 2362

Query: 915  LVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE 974
              E++   +G L+ +  +G  VL            +EN  K+             ++  E
Sbjct: 2363 FSEDVISHKGDLRFVTISGQKVL-----------DMENSFKE------------GKEPSE 2399

Query: 975  IEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 1034
            I   +KD      KL+D  E+   L    + + + L +      +        +  +QA 
Sbjct: 2400 IGNLVKD------KLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQAC 2453

Query: 1035 QPDVEEILS----KGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 1090
            + +VE++LS        + +E+ AT   K+  E+L+     V +L +        +A  +
Sbjct: 2454 EANVEKLLSDTVASDPGVLQEQLAT--TKQLQEELAEHQVPVEKLQK--------VARDI 2503

Query: 1091 TTIGASPT---QTVTLVTQPVVT--KETAISKLEMPSSLMLEVPALADFNRAWTELTDWL 1145
              I   P    + V   T  +++  +  + S  E  S L   +        +   L   +
Sbjct: 2504 MEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSI 2563

Query: 1146 SLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE---ELITAAQNLKNKTSN 1202
              ++Q ++ ++V       I E +       QD+ +++  LE   E++T       +T++
Sbjct: 2564 GEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFM----ETAD 2619

Query: 1203 QEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKL 1262
                 ++  ++  +  +++++    Q +   L ++L  +  +     + +Q +      L
Sbjct: 2620 STTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRML 2679

Query: 1263 ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMIT 1322
             S  +    +    ++I E   L  ++   Q N+D    L  +L     A D  +     
Sbjct: 2680 ASGNQPDQDITHFFQQIQE---LNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRV 2736

Query: 1323 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1382
            +N+   +  + K V ERE         L +F   +  F  WL E E +    + +   + 
Sbjct: 2737 QNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKE 2796

Query: 1383 LLEDSKGVKELMKQWQD---LQGEIEAHTDVYHNL---------DENSQKILRSLEGS-- 1428
            L +  + +K L+  W     L  EI        NL            +  IL S+  S  
Sbjct: 2797 LEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVG 2856

Query: 1429 --------DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWL 1480
                     D   +Q  + ++N K+ +L       +  L+A  ++ + +H     +L WL
Sbjct: 2857 SVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWL 2916

Query: 1481 QLKDDELSRQAPIGG--DFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLE 1538
            + K++ L     +        V+ Q + ++AF  EL+   P I    E          L 
Sbjct: 2917 ESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEA---------LA 2967

Query: 1539 GLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQEL 1598
            GL   Y      P  + A+N     +K  EE+N+ WE+    +   QR+++E+   L   
Sbjct: 2968 GLLVTY------PNSQEAEN----WKKIQEELNSRWERATEVTVARQRQLEESASHLACF 3017

Query: 1599 QEATDELDLKLRQAEVIKGSWQPVGDLLID--SLQDHLEKVKALRGEIAPLKENVSHVND 1656
            Q A  +L   L + E++ G    +G L ID   L    ++V+ +  E    ++    +N+
Sbjct: 3018 QAAESQLRPWLMEKELMMG---VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNE 3074

Query: 1657 LARQLTT--LGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEA 1700
             A+ + T    + LS   +   L+ +N +W  L   +  R  Q+ +A
Sbjct: 3075 AAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQA 3121



 Score =  119 bits (297), Expect = 5e-26
 Identities = 248/1464 (16%), Positives = 575/1464 (39%), Gaps = 237/1464 (16%)

Query: 332  LLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVD 391
            L+   QK   T  Q ++ +  W+ QA+  L   + +  QQ    L++ +++L D++  + 
Sbjct: 2043 LVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ 2102

Query: 392  STRDQAANLMAN----RGDHCRKLVEPQISELNHRF--AAISHRIKTGKASIPLKELEQ- 444
            +     A ++ +      ++  KL   +++ L  +   A   +     +  +  KELE+ 
Sbjct: 2103 NRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEA 2162

Query: 445  FNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQR--------GDNLQQR 496
              S +Q+  E  +A  +   N K+ D   D       +  +LL          G +L++ 
Sbjct: 2163 VTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG 2222

Query: 497  ITD----------------------ERKREEIKIKQQ------------LLQTKHNALKD 522
              D                      + + +E+  +QQ            L Q  HN   +
Sbjct: 2223 ALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPE 2282

Query: 523  LRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERK--IKEIDRELQ- 579
             +   ++K  E+  Q+     Q++  LK +  ++ +L    +   E +  ++  ++EL+ 
Sbjct: 2283 EQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELEN 2342

Query: 580  -----KKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLS-KRWREIESKFAQFRRLNFAQI 633
                    E L ++ ++    SED  +   +   + +S ++  ++E+ F + +    ++I
Sbjct: 2343 MHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEP--SEI 2400

Query: 634  HTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPD-------LCAKD 686
              + ++ +   TE      + + S      +H++  L +  Q  N+ D        C  +
Sbjct: 2401 GNLVKDKLKDATE----RYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEAN 2456

Query: 687  FEDLF------------KQEESLKNIKDSLQQSSGRIDIIH--SKKTAALQSATPVERVK 732
             E L             +Q  + K +++ L +    ++ +   ++    ++     +   
Sbjct: 2457 VEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRH 2516

Query: 733  LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP 792
            +QE    +   ++ ++    +R     +++ + +     ++   Q + E EQ L   Q+ 
Sbjct: 2517 VQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQV- 2575

Query: 793  ENWEHAKYKWYLKELQDGIGQRQTVVR---TLNATGEEI---IQQSSKTDASILQEKLGS 846
                        + L   +  +Q + R   +L AT E +   ++ +  T A++LQ KL  
Sbjct: 2576 ---SSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAE 2632

Query: 847  LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE---- 902
            ++ R++++C Q  +++  L++       F+    +   ++E    + +   +P ++    
Sbjct: 2633 VSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHF 2692

Query: 903  -QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQW 961
             QQ++E   +++   E L   + ++ +L+  G  + +      + QD+++N  K      
Sbjct: 2693 FQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLC-----QHQDRVQNLRKD----- 2742

Query: 962  IKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP 1021
                    E Q  ++ + KD    +++L++  + +     WL      +     P  E  
Sbjct: 2743 ------FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSI-----PPTETS 2791

Query: 1022 FDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRA 1081
               +E E  ++  +  +++  SKG                +E+++ +  ++  L+ E+ A
Sbjct: 2792 MSAKELEKQIEHLKSLLDDWASKG--------------TLVEEINCKGTSLENLIMEITA 2837

Query: 1082 KQPDLAPG--LTTIGAS--------PTQTVTLVTQPVVTKETAISKL-----EMPSSLML 1126
                   G  L ++G+S          + +T +   +        KL     E   SL  
Sbjct: 2838 PDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQA 2897

Query: 1127 EVPALADFNRAWTELTDWLSLLDQVIKSQRVMVG--DLEDINEMIIKQKATMQDLEQRRP 1184
             +  + + ++    +  WL   ++V+KS   M      E +       KA + +LEQ  P
Sbjct: 2898 ILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSP 2957

Query: 1185 QLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQW 1244
            +++++  A   L           ++T    +    W ++QE L +R ++  E+     + 
Sbjct: 2958 KIQKVKEALAGL-----------LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQ 3006

Query: 1245 LEAKEEAEQVLGQARAKLESW---KE------GPYTVD--AIQKKITETKQLAKDLRQWQ 1293
            LE           A ++L  W   KE      GP ++D   +  +  + + + K+    +
Sbjct: 3007 LEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARR 3066

Query: 1294 TNVDVANDLALKLLR---DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLL 1350
               +  N+ A  +L    D S   T +V    ++IN  W  +  +++ R + +++     
Sbjct: 3067 QQHEQLNEAAQGILTGPGDVSL-STSQVQKELQSINQKWVELTDKLNSRSSQIDQA---- 3121

Query: 1351 QQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKE-LMKQWQDLQGEIEAHTD 1409
                         + ++     +LQD + K R +     V+  +  Q + ++ ++E  ++
Sbjct: 3122 -------------IVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSE 3168

Query: 1410 VYHNLDENSQKILRSLEGSDDAVL----------LQRRLDNMNFKWSELRKKSLNIRSHL 1459
            +  +L++   ++  +    D+  +          L++RL+ +      L   + +  + L
Sbjct: 3169 IRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRL 3228

Query: 1460 EASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEP 1519
            +A+    ++      EL  WL  K  + ++  PI      +Q Q   +  F++ L     
Sbjct: 3229 QAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHS- 3287

Query: 1520 VIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNL 1579
                + E +         EG   L   P   P EE+     R L+ Q  E+   WE+L+ 
Sbjct: 3288 ---GSYEVI-------VAEGESLLLSVP---PGEEK-----RTLQNQLVELKNHWEELSK 3329

Query: 1580 HSADWQRKIDETLERLQELQEATDEL-----DLKLRQAEVIKGSWQPVGDLLIDSLQDHL 1634
             +AD Q ++ + +++ Q+ Q   ++L     D K + +E ++ +  PV       L+  L
Sbjct: 3330 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE-LRVTLDPV------QLESSL 3382

Query: 1635 EKVKALRGEIAPLKENVSHVNDLA 1658
             + KA+  E+   +  +  +N  A
Sbjct: 3383 LRSKAMLNEVEKRRSLLEILNSAA 3406



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 155/922 (16%), Positives = 347/922 (37%), Gaps = 160/922 (17%)

Query: 20   RQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDL 76
            RQ  LE ++ +  + + +L  +   LT  ++ L A      D   +  E  K   +++D+
Sbjct: 4758 RQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDV 4817

Query: 77   TSHEISLEEMKK------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR--------LFQK 122
             +H+ ++E + K       +   + A  + S+++   +  + V  K            Q+
Sbjct: 4818 LAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQ 4877

Query: 123  PANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 182
               F   +++  + L  ++  L A +      E  + QL+  + LY  L   +     ++
Sbjct: 4878 AQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLL 4937

Query: 183  KTGR-QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNV 241
              GR  ++ +  + +  + ++ V  L+  ++ + +K+ ERK +LE+ L L+ + +  +  
Sbjct: 4938 DKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQE 4997

Query: 242  LTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 301
               WL   +  L   S    + + + S++   K    E+   +  +  + + G  LK + 
Sbjct: 4998 FINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLS 5057

Query: 302  GKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL 360
             K++  L+++ L  + S W  V  R+                            I+    
Sbjct: 5058 QKQDVVLIKNLLVSVQSRWEKVVQRS----------------------------IERGRS 5089

Query: 361  LDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELN 420
            LD++ +K+ +Q  +  K+L   L D    +DS  +     ++N  D              
Sbjct: 5090 LDDA-RKRAKQFHEAWKKLIDWLEDAESHLDSELE-----ISNDPD-------------- 5129

Query: 421  HRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNE 480
                         K  + L + ++F   +       +  I+ G  LKE+    + ++  +
Sbjct: 5130 -------------KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLD 5176

Query: 481  GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQW-Y 539
              + E+  + D +  +  + + + E  +              L S +   AL+    W Y
Sbjct: 5177 NFLGEVRDKWDTVCGKSVERQHKLEEAL--------------LFSGQFMDALQALVDWLY 5222

Query: 540  QYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDG 599
            + + Q  +      D++  +  +    D  K+    +EL K+   +  ++R    L E+ 
Sbjct: 5223 KVEPQLAEDQPVHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRELIENS 5276

Query: 600  A--AMAVEPTQIQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMPLEISY 654
                  V+    +LS RW  + +   ++  RL  A  Q    R+   M++      E + 
Sbjct: 5277 RDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTL 5336

Query: 655  VPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDII 714
                 L + T   Q+L++  +            E + K EE   ++  ++      + + 
Sbjct: 5337 RFRGALPDDTEALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEVILAVC 5384

Query: 715  HSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI 774
            H      ++    + R + +E L+     W K        Q R + ++ +       ++ 
Sbjct: 5385 HPDCITTIKHWITIIRARFEEVLT-----WAK------QHQQRLETALSELVANAELLEE 5433

Query: 775  FNQWLTEAEQFLRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTLN---- 822
               W+  AE  L +     IP+N +  K     ++ +++E+         V +T      
Sbjct: 5434 LLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI 5493

Query: 823  ------------ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLSDRKKR 864
                        + G + + Q +     IL +      ++  L+ RWQ+V     +R+++
Sbjct: 5494 EPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRK 5553

Query: 865  LEEQKNILSEFQRDLN-EFVLW 885
            L +  + L E +   N +F +W
Sbjct: 5554 LNDALDRLEELKEFANFDFDVW 5575



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 114/578 (19%), Positives = 219/578 (37%), Gaps = 111/578 (19%)

Query: 1112 ETAISKLEMPSSLMLEVPALADFNRAWTELTDWL---SLLDQVIKSQRVMVG-DLEDINE 1167
            E  +S L +  ++ +    +        EL D L    +L++ +K    +V  +LE +N+
Sbjct: 1808 EKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQ 1867

Query: 1168 MIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHL 1227
            +II Q       E     L+ L   A+NL+   S+         R+   QN  +  +  +
Sbjct: 1868 IIISQPQ-----EVPAQLLKALEKDAKNLQKSLSS--VSDTWNSRLLHFQNAVEIEKTKV 1920

Query: 1228 QNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAK 1287
             N+  QL   L+D   W+  K     +L    +  E        VD++   + + + L +
Sbjct: 1921 LNQHTQLEGRLQDLRAWVGNKN---LILNSKGSNSE------IDVDSLNLCLQQYEDLKQ 1971

Query: 1288 DLRQWQTNVD-VANDLALKL---LRDYSADDTRKVHMITENINASWRSI----------- 1332
             + + +  +D +A D+   +    +D S    R++  +   +  S++ I           
Sbjct: 1972 PMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDAL 2031

Query: 1333 --HKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGV 1390
              H +  E+EA ++   +        LE   +W+ +AE      Q  T ++ L    K  
Sbjct: 2032 QGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQ 2091

Query: 1391 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG---SDDAVLLQRRLDNMNFKWSE 1447
             +L    +DLQ +I+       N   +   +++ +EG    +   L  R L       + 
Sbjct: 2092 SDL----KDLQDDIQ-------NRATSFATVVKDIEGFMEENQTKLSPREL-------TA 2133

Query: 1448 LRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 1507
            LR+K    +   EA  ++ +     L+E +                     A+Q++ +  
Sbjct: 2134 LREKLHQAKEQYEALQEETRVAQKELEEAVT-------------------SALQQETEKS 2174

Query: 1508 RAFKRELKTKEPV------IMSTLETVRIFLTEQPLEGLEKL---------------YQE 1546
            +A K   + K+ +      + S   +    LT  P  G+E+L               Y  
Sbjct: 2175 KAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLP--GMEQLSGASLEKGALDTTDGYMG 2232

Query: 1547 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE-----TLERLQELQEA 1601
              + P  E+      +++ + +E+ ++ +   L +   Q  +D+     T E  Q LQ+ 
Sbjct: 2233 VNQAP--EKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQK 2290

Query: 1602 TDEL----DLKLRQAEVIKGSWQPVGDLLIDSLQDHLE 1635
              EL       L Q+E      Q + D L   LQDH E
Sbjct: 2291 LGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKE 2328


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score =  251 bits (642), Expect = 5e-66
 Identities = 344/1741 (19%), Positives = 730/1741 (41%), Gaps = 207/1741 (11%)

Query: 17   AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEA---QKIQ 73
            A  RQK LE  +  A++  ++   I + L+  +K+LA         A++ Q+    + ++
Sbjct: 3374 AAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALE 3433

Query: 74   SDLTSHEISLEEMKKHNQG-----KEAAQRVLSQ-IDVAQKKLQDVSMKFRLFQKPANFE 127
             D+ +H   + +  K  Q        A Q VLS+ ID  Q +  ++  + R  +K A  +
Sbjct: 3434 EDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEI--QDRCCRKAALLD 3491

Query: 128  QRLQESKMI----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSE 177
            Q L  +++           L EV+  L ++  K  +Q+V+  Q    + L + +   K  
Sbjct: 3492 QALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKN 3551

Query: 178  VEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRK 237
            V+  IK G+ ++++   E    + E++  +K  Y ++    ++  + LE+  +L+ K + 
Sbjct: 3552 VDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQS 3611

Query: 238  EMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQ----KVHLKSITEV 293
                LT WL   + EL    A  G  S    ++   +  QKE++K+    ++ L ++ EV
Sbjct: 3612 TYEELTGWLREVEEEL----ATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEV 3667

Query: 294  GEALKTVLGKKETLVEDKL-SLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITK 352
              AL  ++  +     DKL S  N  +  V+    + ++ +    +  + ++Q  D    
Sbjct: 3668 SRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELA 3727

Query: 353  WIIQADTLLD-----ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDH 407
            W+ +    L        E+ +   +  V K    ++   +  +D      + +    G+ 
Sbjct: 3728 WVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEE 3787

Query: 408  CRKLVEPQISELNHRFAAIS-----HRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQ 462
             + +++ +   L  ++ AIS        +  +A + + +  +   ++   +E   A I Q
Sbjct: 3788 QKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ 3847

Query: 463  --GVNLKEEDFNKDMNE---------DNEGTVKELLQRGDNLQQRITDERKREEIKIKQQ 511
                 +  E   +   E         +++  + +LL+ G  L+     E   EE ++ ++
Sbjct: 3848 LPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLK-----ELNPEEGEMVEE 3902

Query: 512  LLQTKHNALKDLRSQRRKKALEI------SHQWYQYKRQADDLLKCLDDIEKKLASLPE- 564
              Q   N    ++ + R++AL +      S Q  ++  + + +L+ L+++  +L   P  
Sbjct: 3903 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 3962

Query: 565  PRDERKIKEIDR-------ELQKKKEELNAVRRQAE-------GLSEDGAAMAVEPTQIQ 610
            P +  KI+E          EL+K +    A++R+ E       G  +D AA  ++    Q
Sbjct: 3963 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQ 4022

Query: 611  LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 670
            +   W +I+++ A+ R + F  +  + E+              Y  +  LT I      +
Sbjct: 4023 MVFFWEDIKAR-AEEREIKFLDVLELAEKFW------------YDMAALLTTIKDTQDIV 4069

Query: 671  LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 730
             ++E     P +       + +Q E+ + IK+        ++ I       + +    E+
Sbjct: 4070 HDLESPGIDPSI-------IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEK 4122

Query: 731  VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ 790
             ++++++ +++  WE +NK +K+R  + + +++   ++   ++    WL      L  T 
Sbjct: 4123 PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLC-TM 4181

Query: 791  IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSS-KTDASILQEKLGS 846
             P   +    K  L E+++    + Q+Q  +  LN  GE ++++++ +TD  I++E L  
Sbjct: 4182 PPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTE 4241

Query: 847  LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI--ASIPLEPGKEQQ 904
            L   W+ + ++++ R+ +LE     L +FQ  L E + WL   + +  A  P+  G  + 
Sbjct: 4242 LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPIS-GDPKV 4300

Query: 905  LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKV 964
            ++ +L +  +L  ++   Q  ++ +N+ G  +L S+  + ++   L ++L+  N  W  V
Sbjct: 4301 IEVELAKHHVLKNDVLAHQATVETVNKAGNELLESS--AGDDASSLRSRLEAMNQCWESV 4358

Query: 965  SRALPEKQ--------------GEIEAQIKDLGQLEKKL----------EDLEEQLNHLL 1000
             +   E++               EIE  + +L ++E +L          E   EQL+  +
Sbjct: 4359 LQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHM 4418

Query: 1001 LWLSPIRNQLEIYNQPNQEGPFDV-QETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK 1059
               S ++ + E YNQ   +G   +    +    +K      +L +  H+   K   +  K
Sbjct: 4419 ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEER--K 4476

Query: 1060 RKLED---LSSEWK-------------------------AVNRLLQELRAKQP------- 1084
             KLE+   L++E++                          +N +L ++   +        
Sbjct: 4477 SKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNA 4536

Query: 1085 --DLAPGLTTIG-----ASPTQTVTLVTQPVVTKETAISK-----LEMPSSLMLEVPALA 1132
              D    L   G      S  Q V L+   +V+ ++   K     +E   SL        
Sbjct: 4537 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 4596

Query: 1133 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITA 1192
             F+ AW +L DWL   +  + S+  +  D + I   + K K   + L  ++P  +  I  
Sbjct: 4597 QFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRT 4656

Query: 1193 AQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 1252
             + LK KT   E    + + +  ++++WD V      R+ +L E L  S Q+++A +   
Sbjct: 4657 GRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALV 4716

Query: 1253 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 1312
              L +   +L   +     +D +   +   K   K+L +    V V      +L+ + S 
Sbjct: 4717 DWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-SR 4775

Query: 1313 DDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT-- 1370
            DDT  V    + ++  W ++ K    +++ LE+  +  + F   +   L WL+EAE T  
Sbjct: 4776 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 4835

Query: 1371 -ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 1429
                L D T   + L D+   KE MK+ ++ + ++ +   +         +++ ++   D
Sbjct: 4836 FRGALPDDTEALQSLIDTH--KEFMKKVEEKRVDVNSAVAM--------GEVILAVCHPD 4885

Query: 1430 DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR 1489
                ++  +  +  ++ E+   +   +  LE +  +       L+ELL W+Q  +  L +
Sbjct: 4886 CITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQ 4945

Query: 1490 --QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVI--------MSTLETVRIFLTEQPLEG 1539
              Q PI  +   V+     H+ F  E+  K+P +           +E       E+   G
Sbjct: 4946 RDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSG 5005

Query: 1540 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 1599
              K   +P   PP     + +     +  +++  W+++ L + + QRK+++ L+RL+EL+
Sbjct: 5006 GRKSLSQP--TPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELK 5063

Query: 1600 E 1600
            E
Sbjct: 5064 E 5064



 Score =  249 bits (635), Expect = 3e-65
 Identities = 337/1747 (19%), Positives = 735/1747 (42%), Gaps = 180/1747 (10%)

Query: 19   RRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLA---AYIADKVDAAQMPQEAQK---- 71
            R+ K L  +  +A+E E    ++   +  I++QLA    +  ++VD  QM  +       
Sbjct: 3173 RKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQ 3232

Query: 72   --IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQK 122
              IQS     D+   E  +EE+    +   K+ AQR+         +LQ+  +       
Sbjct: 3233 GLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA--------QLQEALLHC----- 3279

Query: 123  PANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 182
               F+  L+     L + +  +   +  S E +VV++Q+     L + L + K+ V+M+ 
Sbjct: 3280 -GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3338

Query: 183  KTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVL 242
              G +I Q  +  + +++  ++ +L+  + EL +K   R++QLE  L L+++  +    +
Sbjct: 3339 AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPI 3398

Query: 243  TEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 302
            +++L+ T+ +L     V    + +  ++   KA +++IE     +    ++G++L ++  
Sbjct: 3399 SDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTS 3458

Query: 303  KKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL 361
              E  ++ +K+  L + +  +  R      LL +   +   F ++   +  W+ + +  L
Sbjct: 3459 PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKL 3518

Query: 362  DESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEP 414
                 K    K+DVL R       L  E+ + +  VD        L+         L++ 
Sbjct: 3519 SSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQE 3576

Query: 415  QISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKD 474
            ++  +  R+A I+  + + KA   L++  Q  +  Q   E L   +++   ++EE     
Sbjct: 3577 KLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYEELTGWLRE---VEEELATSG 3631

Query: 475  MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALE- 533
                    + +  QR   L++ + + R      +    +     AL +L   R ++ L+ 
Sbjct: 3632 GQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVNEVSRALLELVPWRAREGLDK 3685

Query: 534  -ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDREL------QKKKEELN 586
             +S    QYK  +D + + +D+I+  +      R ++  +  D EL      ++K   L 
Sbjct: 3686 LVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQAADAELAWVAETKRKLMALG 3740

Query: 587  AVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ----FRRLNFAQIHTVREETM 641
             +R + +   +  A + V+    I + +    ++  F+     F      Q   ++E+T 
Sbjct: 3741 PIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTE 3797

Query: 642  MVMTEDMPLEI------------SYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 689
             ++ +   + +              + + +      +S  + E   L+      A D E 
Sbjct: 3798 SLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQ 3857

Query: 690  LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 749
            L +Q+E ++ +++S+ +    ID +  K    L+   P E   ++E   + +  + ++ +
Sbjct: 3858 LRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKE 3916

Query: 750  MYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFLRKTQ-IPENWEHAKYKWYLK 805
              + R    D +V +  +   FH  I+   + L      LR    IP   E  K +  + 
Sbjct: 3917 EVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPA--EVDKIRECIS 3974

Query: 806  ELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQL 858
            + +     + + Q     L   GEE+I +S   D  +    +Q+KL  +   W+++  + 
Sbjct: 3975 DNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARA 4034

Query: 859  SDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVE 917
             +R+ +  +   +  +F  D+   +  +++  +I      PG +  + K+++E  + + E
Sbjct: 4035 EEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4094

Query: 918  ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 977
            E       L+ +   G  ++ +      E+ ++   + + N  W  +++   E+  ++E 
Sbjct: 4095 ETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4152

Query: 978  QIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAK 1034
             ++   Q +  L+ + + L++ ++ L    P+   L        E    ++E ++ V  +
Sbjct: 4153 AMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE----MKEFKVEVYQQ 4208

Query: 1035 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 1094
            Q ++E++  +G+ + K+  AT    R +         +   L EL+    +L        
Sbjct: 4209 QIEMEKLNHQGELMLKK--ATDETDRDI---------IREPLTELKHLWENLG------- 4250

Query: 1095 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 1154
                            ++ A  + ++  +L+    AL  F  A  EL  WL+  ++++ +
Sbjct: 4251 ----------------EKIAHRQHKLEGALL----ALGQFQHALEELMSWLTHTEELLDA 4290

Query: 1155 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 1214
            QR + GD + I   + K      D+   +  +E +  A   L   ++  +A + +  R+E
Sbjct: 4291 QRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASS-LRSRLE 4349

Query: 1215 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 1274
             +   W+ V +  + R QQL   L+ +  +    E+    L +  ++L + K      + 
Sbjct: 4350 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPET 4409

Query: 1275 IQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1333
             ++++    +L   L+ + +T   + +   L LL    +    K       +   W  + 
Sbjct: 4410 AREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVS 4469

Query: 1334 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1393
             ++ ER++ LEE   L  +F   L++F+ WLT AE + N+   A+    +L     V   
Sbjct: 4470 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI---ASPPSLILNT---VLSQ 4523

Query: 1394 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1453
            +++ +    E+ AH D    LD+   + L+ L    D VL++  L ++  +W ++ ++S+
Sbjct: 4524 IEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI 4582

Query: 1454 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1513
                 L+ +  + K+ H + ++L+ WL+  +  L  +  I  D   ++ Q   H+ F++ 
Sbjct: 4583 ERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKT 4642

Query: 1514 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1573
            L  K+PV  +T+ T R                + + L PE+ +Q +   L     EV  +
Sbjct: 4643 LGGKQPVYDTTIRTGRAL--------------KEKTLLPED-SQKLDNFL----GEVRDK 4683

Query: 1574 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQD 1632
            W+ +   S + Q K++E L    +  +A   L   L + E      QPV GDL  D + +
Sbjct: 4684 WDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDL--DLVMN 4741

Query: 1633 HLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKL---LQVA 1689
             ++  K  + E+      V  +    R+L       + +    L++L+TRW     L V+
Sbjct: 4742 LMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVS 4801

Query: 1690 VEDRVRQ 1696
             + R+ Q
Sbjct: 4802 KQSRLEQ 4808



 Score =  211 bits (538), Expect = 5e-54
 Identities = 284/1603 (17%), Positives = 653/1603 (40%), Gaps = 161/1603 (10%)

Query: 99   VLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQ 158
            +LS+    QK+L+D+ +  + F + A      +     L   +  L   E    +   +Q
Sbjct: 3370 LLSKAAARQKQLEDILVLAKQFHETA------EPISDFLSVTEKKLANSEPVGTQTAKIQ 3423

Query: 159  SQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKV 218
             Q+     L + +    ++V   +K G+ +           L E++ +L+  Y+E+  + 
Sbjct: 3424 QQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC 3483

Query: 219  TERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQK 278
              +   L++ L  +R   ++   +  WLA  + +L+     +     L  + A   A  +
Sbjct: 3484 CRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNE 3543

Query: 279  EIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 337
            EI  +K ++    + G+AL K   G++  L+++KL  + + +  +T  + + L  L + +
Sbjct: 3544 EIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQAR 3603

Query: 338  KHMETFDQNVDHITKWIIQADTLLDESEKKKPQ-----QKEDVLKRLKAELNDIRPKVDS 392
            +    F    + +T W+ + +  L  S  + P      Q +   K LK E+ + R  +D+
Sbjct: 3604 QLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDT 3663

Query: 393  TRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI--KTGKASIPLKELEQF----N 446
              + +  L+       R+ ++  +S+ N ++  +S  I  +  +    ++  +Q+    +
Sbjct: 3664 VNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAAD 3723

Query: 447  SDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD------- 499
            +++  + E     +  G    E+D      +  +    ++++  D++ +  +        
Sbjct: 3724 AELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT 3783

Query: 500  --ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 557
              E ++  ++ K + L  ++ A+  L S+R  +         Q+    ++L   +++   
Sbjct: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 3843

Query: 558  KLASLPEPR-DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA-VEPTQIQL-SKR 614
             +A LP P  D  ++++   E+++ +E +   +   + L + G  +  + P + ++  ++
Sbjct: 3844 LIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEK 3903

Query: 615  WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVE 674
            +++ E+ +AQ           ++EE   V    + L+ +   ST +TE     + +LE  
Sbjct: 3904 YQKAENMYAQ-----------IKEE---VRQRALALDEAVSQSTQITEFHDKIEPMLETL 3949

Query: 675  QLLNA----PDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 730
            + L++    P L   + + + +     K+    L++     + +  +    +  +   ++
Sbjct: 3950 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4009

Query: 731  ----VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL 786
                 ++Q+ L Q+ F WE +    ++R+ +F   +E   +F YD+      + + +  +
Sbjct: 4010 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4069

Query: 787  RKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDAS 838
               + P        +  E A+    +KE  DG+ +    +R L   G ++I    +T+  
Sbjct: 4070 HDLESPGIDPSIIKQQVEAAET---IKEETDGLHEELEFIRIL---GADLIFACGETEKP 4123

Query: 839  ILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPL 897
             +++ +  +N  W+ + K   +R ++LE+      ++Q  L     WL+     + ++P 
Sbjct: 4124 EVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4183

Query: 898  EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 957
                   +K++L ++K    E+  +Q  +++LN  G  +L  A     ++D +   L + 
Sbjct: 4184 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKAT-DETDRDIIREPLTEL 4242

Query: 958  NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 1017
               W  +   +  +Q ++E  +  LGQ +  LE+L       + WL+     L+   Q  
Sbjct: 4243 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEEL-------MSWLTHTEELLDA--QRP 4293

Query: 1018 QEGPFDVQETEIA--------VQAKQPDVEEILSKGQHLYKEKPA--TQPVKRKLEDLSS 1067
              G   V E E+A        V A Q  VE +   G  L +         ++ +LE ++ 
Sbjct: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQ 4353

Query: 1068 EWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 1127
             W++V   LQ+   ++  L   L       ++           ++  +    M S L   
Sbjct: 4354 CWESV---LQKTEEREQQLQSTLQQAQGFHSEI----------EDFLLELTRMESQLSAS 4400

Query: 1128 VPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE 1187
             P       A  +L   + L  Q+   +       E  N+++ K +  +           
Sbjct: 4401 KPTGGLPETAREQLDTHMELYSQLKAKE-------ETYNQLLDKGRLML----------- 4442

Query: 1188 ELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEA 1247
                    L    S   ++T     +  ++ +W  V   ++ R+ +L E L  +T++  +
Sbjct: 4443 --------LSRDDSGSGSKT--EQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNS 4492

Query: 1248 KEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL 1307
             +E    L  A   L         ++ +  +I E K  A ++   +  +   +    +L 
Sbjct: 4493 LQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLK 4552

Query: 1308 RDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEA 1367
                  D   +  +  ++ + W  + +R  ER  +L++  +  +QF    +K + WL +A
Sbjct: 4553 FLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDA 4612

Query: 1368 ETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG 1427
            E+  +       +  +  D   +K  + + ++ Q  +     VY       + +      
Sbjct: 4613 ESHLD------SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLL 4666

Query: 1428 SDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 1487
             +D+  L   L  +  KW  +  KS+  +  LE +     +   +LQ L+ WL   + +L
Sbjct: 4667 PEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQL 4726

Query: 1488 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 1547
            +   P+ GD   V    D H+ F++EL  +   +                   + L +  
Sbjct: 4727 AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTV-------------------QVLKRSG 4767

Query: 1548 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDL 1607
            REL   E +++ T  ++ Q +E++T W+ +   S   Q ++++ L++ +  ++    L  
Sbjct: 4768 RELI--ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 4825

Query: 1608 KLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVKALRGEI 1644
             L +AE        + D       LID+ ++ ++KV+  R ++
Sbjct: 4826 WLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDV 4868



 Score =  209 bits (531), Expect = 3e-53
 Identities = 336/1819 (18%), Positives = 737/1819 (40%), Gaps = 202/1819 (11%)

Query: 24   LEQSIQSAQETEKSLHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEI 81
            LE+  Q  +E ++S   I++ +     QL  +  +  +  + +  ++ +  Q  L + E 
Sbjct: 2943 LEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002

Query: 82   SLEEMKKHNQGK-------EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANF 126
             ++ ++   QG          A ++L Q +VAQ++  +V  +            +    F
Sbjct: 3003 QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQF 3062

Query: 127  EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 186
              R++E    L ++   L  +     + + +QSQ+         +  +K ++E      R
Sbjct: 3063 HCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECR 3122

Query: 187  QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 246
             +++++ T +   L   + AL     +L  +   R++QLE  L       +++  L +  
Sbjct: 3123 HMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDAT 3182

Query: 247  AATDMELTKRSAVEGMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKE 305
             A +     +  V      ++ ++A  K  QKE ++  ++ L+ +  +G+ L    GK  
Sbjct: 3183 TAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDC 3242

Query: 306  TL--VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDE 363
             +  +E  +  +N+ W  +  +  + +  L E   H   F   ++ +  W+   + L+  
Sbjct: 3243 DVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-- 3300

Query: 364  SEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI 416
            + +K P  +  V+K        L+  L+D +  VD  + +   +  +     R+ +  Q+
Sbjct: 3301 ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQL 3360

Query: 417  SELNHRFAAISHRIKTGKASIPLKELEQ-----------------FNSDIQKLL---EPL 456
              L  R+  +       KA+   K+LE                  F S  +K L   EP+
Sbjct: 3361 ESLESRWTEL-----LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3415

Query: 457  ---EAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLL 513
                A+IQQ + ++ +   +D+ E++   V + ++ G +L   +T   ++  +  K   L
Sbjct: 3416 GTQTAKIQQQI-IRHKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSL 3472

Query: 514  QTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKE 573
            Q +++ ++D   ++     +       +     ++L  L ++E KL+S+        +K+
Sbjct: 3473 QARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKD 3525

Query: 574  IDRELQKKK--------EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQF 625
              +++  ++        EE+   ++  +   ++G A+  + T  ++     +++      
Sbjct: 3526 FKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI---- 3581

Query: 626  RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 685
             +  +A I     + +  + +   L   +  STY      ++  L EVE+ L      + 
Sbjct: 3582 -KTRYADITVTSSKALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSP 3635

Query: 686  DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 745
              E + + ++  K +K  + +    +D ++    A L+      R  L + +S  + Q++
Sbjct: 3636 TGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYK 3695

Query: 746  KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKW 802
             V+     R    D ++++ +++         W+ E ++ L      ++ ++   A+ + 
Sbjct: 3696 LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ- 3754

Query: 803  YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 862
              K     I + +  +  L +   EI     +   ++LQEK  SL  +++ +    S+R 
Sbjct: 3755 VQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERY 3814

Query: 863  KRLEEQKNILSEFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPL 921
             RLE  + ++++F     E   W+EE    IA +P      +QL+++ E+++ L E +  
Sbjct: 3815 ARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAE 3874

Query: 922  RQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQ 978
             +  + +L + G  +     ++PEE + +E K ++    + ++   + ++     E  +Q
Sbjct: 3875 HKPHIDKLLKIGPQL---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQ 3931

Query: 979  IKDLGQLEKKLEDLEEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQ 1032
               + +   K+E + E L +L   L + P+     +++      N+    ++++ + + +
Sbjct: 3932 STQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFE 3991

Query: 1033 AKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK---------- 1082
            A +   EE++ + Q   K+  A + ++ KL+ +   W+ +    +E   K          
Sbjct: 3992 ALKRRGEELIGRSQGADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEK 4050

Query: 1083 -QPDLAPGLTTIG---------ASPTQTVTLVTQPVVTKETA------------------ 1114
               D+A  LTTI           SP    +++ Q V   ET                   
Sbjct: 4051 FWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILG 4110

Query: 1115 ---------ISKLEMPSSLMLEVPALADFNRAWTE---------------------LTDW 1144
                       K E+  S+     A  + N+ W E                     + DW
Sbjct: 4111 ADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDW 4170

Query: 1145 LSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE 1204
            L      + +   +  DL  + + + + K    ++ Q++ ++E+L    + +  K +++ 
Sbjct: 4171 LDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDET 4230

Query: 1205 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLES 1264
             R II + +  +++ W+ + E + +R+ +L   L    Q+  A EE    L      L++
Sbjct: 4231 DRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDA 4290

Query: 1265 WKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITEN 1324
             +        I+ ++ +   L  D+   Q  V+  N    +LL   + DD   +    E 
Sbjct: 4291 QRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEA 4350

Query: 1325 INASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLL 1384
            +N  W S+ ++  ERE  L+ T +  Q F  ++E FL  LT  E+  +    A++    L
Sbjct: 4351 MNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGL 4406

Query: 1385 EDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFK 1444
             ++   +E +    +L  +++A  + Y+ L +  + +L S + S      ++ +  +  K
Sbjct: 4407 PET--AREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQK 4464

Query: 1445 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQN 1504
            W  +  K    +S LE + +       SLQE + WL L +  L+  +P       V  Q 
Sbjct: 4465 WHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI 4524

Query: 1505 DVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR 1564
            + H+ F  E+      I+                   +L Q   +L    + Q+V  L++
Sbjct: 4525 EEHKVFANEVNAHRDQII-------------------ELDQTGNQLKFLSQKQDVV-LIK 4564

Query: 1565 KQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG- 1623
                 V + WEK+   S +  R +D+  +R ++  EA  +L   L  AE    S   +  
Sbjct: 4565 NLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 4624

Query: 1624 --DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNT 1681
              D +   L  H E  K L G+  P+ +         ++ T L       + + L ++  
Sbjct: 4625 DPDKIKLQLSKHKEFQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRD 4682

Query: 1682 RWKLLQVAVEDRVRQLHEA 1700
            +W  +     +R  +L EA
Sbjct: 4683 KWDTVCGKSVERQHKLEEA 4701



 Score =  155 bits (393), Expect = 3e-37
 Identities = 297/1513 (19%), Positives = 615/1513 (40%), Gaps = 181/1513 (11%)

Query: 148  ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENP--KELDERVT 205
            +T + +  V+Q QL     L + L+E +  VE + K  R I++ +    P  + + E   
Sbjct: 1961 DTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTD 2020

Query: 206  ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 265
            ++  H+  L   + ER   L+K +  S+ +++ +  L + +   +  L  +         
Sbjct: 2021 SILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGV 2080

Query: 266  LDSEVAWGKATQKEIEKQKVHLKSITE-VGEALKTVLGKKETLVEDKLSLLN-------- 316
            +   +A     +++I +QK  L++  E V   ++T       +++ KL+ ++        
Sbjct: 2081 IQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCL 2140

Query: 317  ------SNWIAVTSRAEEWLNLLLEYQKHMETF----------DQNVDHITKWIIQADTL 360
                  S+   +  +AE + +L  + Q+ ME            DQ++ H  + I + +  
Sbjct: 2141 QQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNL- 2199

Query: 361  LDESEKKKPQQKEDVLKRLKAELNDIRPKVD--STRDQAANLMANRGDHCRKLVE----- 413
                E +  Q+  D L+ L  EL+     +D    +D+  NL  +  +  + + E     
Sbjct: 2200 ----EMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDA 2255

Query: 414  ----PQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA---------EI 460
                 Q+ E           +K  + SIP  E      +++K +E L++          +
Sbjct: 2256 SSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL 2315

Query: 461  QQGVNLKEEDFNKDMNE----DNEGTVKELLQRGDNLQQRITDE---RKREEIKIKQQLL 513
             + +N K       + E    D++G    +L    +    +      +   EI+     +
Sbjct: 2316 VEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDV 2375

Query: 514  QTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKE 573
              K+  L  +  +R++    I ++  +  ++A+ +L+ L+  E+ L S+       K + 
Sbjct: 2376 NLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTET 2435

Query: 574  IDRELQKKK---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKF-AQFRRLN 629
            +  + +  K    EL     + + + E  A + V     Q ++ W++I+ +  +++ R  
Sbjct: 2436 VKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERAT 2495

Query: 630  FAQIHTVR--EETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVE-QLLNAP----DL 682
               +   R  EE+   +      E    P     E+       L ++  +LNA       
Sbjct: 2496 EVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQF 2555

Query: 683  CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDF 742
              K+FE   +Q E L      +    G + +  S+    LQS    + V+L + L+    
Sbjct: 2556 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQ-KWVELTDKLNSRSS 2614

Query: 743  QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKW 802
            Q ++        Q       EK R     + + +   T+ E   ++ +     E ++ + 
Sbjct: 2615 QIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLE-----ETSEIRS 2669

Query: 803  YLKELQDGIGQRQTVVRTLNA-TGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDR 861
             L++L   + + QT+   L+   GE+ ++         L+++L ++ L  Q +    +DR
Sbjct: 2670 DLEQLDHEVKEAQTLCDELSVLIGEQYLKDE-------LKKRLETVALPLQGLEDLAADR 2722

Query: 862  KKRLEEQKNILSEFQRDLNEFVLWLE--EADNIASIPLEPGKEQQLKEKLEQVKLLVEEL 919
              RL+       +FQ+  +E   WL+  ++    + P+   K ++L+ +L++ +   + L
Sbjct: 2723 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPIS-AKLERLQSQLQENEEFQKSL 2781

Query: 920  PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 979
                G  + +   G  +L+S P   EE+  L+N+L +    W ++S+   ++Q    +++
Sbjct: 2782 NQHSGSYEVIVAEGESLLLSVP-PGEEKRTLQNQLVELKNHWEELSKKTADRQ----SRL 2836

Query: 980  KDLGQLEKK-----------LEDLEEQLNHLLLWLSPI-------------------RNQ 1009
            KD  Q  +K           +ED + +++ L + L P+                   R+ 
Sbjct: 2837 KDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSL 2896

Query: 1010 LEIYN----------QPNQEGPFD----VQETEIAV----QAKQPDVEEI---LSKGQHL 1048
            LEI N          + +++G  D    + +   AV    QAK   +EE+   L + Q  
Sbjct: 2897 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 2956

Query: 1049 YKE-KPATQPVKRKLE--DLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 1105
            +K  +   +  K +LE  D        N+ L++LRA+Q  L      +      T  LV 
Sbjct: 2957 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3016

Query: 1106 QPVVTKETA--ISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLE 1163
                  + +  + + E+     LEV      N     + + L  + Q     R M   L 
Sbjct: 3017 DAPDGSDASQLLHQAEVAQQEFLEVKQRV--NSGCVMMENKLEGIGQFHCRVREMFSQLA 3074

Query: 1164 DINEMIIKQKATMQDLEQRRPQLEELITAAQ-----NLKNKTSNQEARTIITD------- 1211
            D+++ +    A  +D +  + Q+E++           L  + S  E R ++ +       
Sbjct: 3075 DLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLL 3134

Query: 1212 ----RIERIQNQWDEVQEHLQNRRQQLNEML---KDSTQWLEAKEEAEQVLGQARAKLES 1264
                 +E +  Q  ++ E  + R++QL   L   +D  + L+   +A     +A A    
Sbjct: 3135 GLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEAL--Q 3192

Query: 1265 WKEGPYTVDAIQKKITETKQLAKD-LRQWQTNVDVANDLALKLLRDYSAD-DTRKVHMIT 1322
            W  G   V+ I +++ + K   K+ +   Q  +   N L   L++    D D + +    
Sbjct: 3193 WVVGT-EVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDM 3251

Query: 1323 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1382
            E INA W +++K+V++R A L+E      +F   LE  L+WL + E        A +K  
Sbjct: 3252 EEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-----ANQKPP 3306

Query: 1383 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1442
              E  K VK  +++ + LQ  ++        L     +I +S E + D   +  +L+++ 
Sbjct: 3307 SAE-YKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA-DREKITGQLESLE 3364

Query: 1443 FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQK 1502
             +W+EL  K+   +  LE      K+ H + + +  +L + + +L+   P+G     +Q+
Sbjct: 3365 SRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ 3424

Query: 1503 QNDVHRAFKRELK 1515
            Q   H+A + +++
Sbjct: 3425 QIIRHKALEEDIE 3437



 Score =  142 bits (359), Expect = 3e-33
 Identities = 328/1739 (18%), Positives = 672/1739 (38%), Gaps = 276/1739 (15%)

Query: 28   IQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMK 87
            I   + T++ L  ++  L  +  +  +++     ++ +P     ++S+L      L E  
Sbjct: 1091 IAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPT----LRSELNL----LVEKM 1142

Query: 88   KHNQGKEAAQ-RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPA 146
             H  G        L  +DV  + +QD  +  +       +E +L + +++L +    L A
Sbjct: 1143 DHVYGLSTVYLNKLKTVDVIVRSIQDAELLVK------GYEIKLSQEEVVLAD----LSA 1192

Query: 147  LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENP-KELD---- 201
            LE          S L H ++  K  + V S ++  I   + + ++     P + LD    
Sbjct: 1193 LEAH-------WSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERY 1245

Query: 202  -ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 260
             E+ + L+  ++ + A++  R+ +LE   ++    R     L +W+  T  +       +
Sbjct: 1246 QEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQ 1305

Query: 261  GMPSNLDSE-VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNW 319
               S + SE ++   A   EIE+ +  L    +  +   T++   E  +    + + S  
Sbjct: 1306 AEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQ 1365

Query: 320  IAVTSR----------AEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 369
             +   R           +E+++L   Y   +    Q+V    K+I  A   L+E EK   
Sbjct: 1366 KSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHV----KYISDALRRLEEEEKVVE 1421

Query: 370  QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRK-LVEPQI--SELNHRFAAI 426
            ++K++ ++++K  L  +     +T+ +A +          K ++E Q+   EL  +   +
Sbjct: 1422 EEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQV 1481

Query: 427  SHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKEL 486
            S  IKT +  +             KL E  + +I + +N      NK  ++  +G+  +L
Sbjct: 1482 SEAIKTSQIFLAKHG--------HKLSEKEKKQISEQLNA----LNKAYHDLCDGSANQL 1529

Query: 487  LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQ--RRKKALEISHQWYQYKRQ 544
             Q    LQ ++  + +++ ++ KQQ   T H  L+DL S   + ++AL   HQ    ++ 
Sbjct: 1530 QQ----LQSQLAHQTEQKTLQ-KQQ--NTCHQQLEDLCSWVGQAERALA-GHQGRTTQQD 1581

Query: 545  ADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAV 604
               L K   D+                K++  ++Q +      V +  EG  E+      
Sbjct: 1582 LSALQKNQSDL----------------KDLQDDIQNRATSFATVVKDIEGFMEEN----- 1620

Query: 605  EPTQIQLSKR-WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEI 663
               Q +LS R    +  K  Q +     Q   ++EET +   E     +    ++ L + 
Sbjct: 1621 ---QTKLSPRELTALREKLHQAKE----QYEALQEETRVAQKE-----LEEAVTSALQQE 1668

Query: 664  THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQ 723
            T  S+A              AK+  +  K+ ++L +   S+  S G++          L 
Sbjct: 1669 TEKSKA--------------AKELAENKKKIDALLDWVTSVGSSGGQL-------LTNLP 1707

Query: 724  SATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE 783
                +    L++        +  VN+  +    + D+  E  +  H ++      L++ +
Sbjct: 1708 GMEQLSGASLEKGALDTTDGYMGVNQAPE----KLDKQCEMMKARHQEL------LSQQQ 1757

Query: 784  QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEK 843
             F+  TQ  + +                         L+  G  +  +  +    +LQ+K
Sbjct: 1758 NFILATQSAQAF-------------------------LDQHGHNLTPEEQQ----MLQQK 1788

Query: 844  LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKE 902
            LG L  ++     Q     K+++  ++ L +F +D  EF  WLE ++  + ++       
Sbjct: 1789 LGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSP 1848

Query: 903  QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWI 962
            + L   L++     E++   +G L+ +  +G  VL            +EN  K+      
Sbjct: 1849 ETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVL-----------DMENSFKE------ 1891

Query: 963  KVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPF 1022
                   ++  EI   +KD      KL+D  E+   L    + + + L +      +   
Sbjct: 1892 ------GKEPSEIGNLVKD------KLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQN 1939

Query: 1023 DVQETEIAVQAKQPDVEEILS----KGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE 1078
                 +  +QA + +VE++LS        + +E+ AT   K+  E+L+     V +L + 
Sbjct: 1940 SADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLAT--TKQLQEELAEHQVPVEKLQK- 1996

Query: 1079 LRAKQPDLAPGLTTIGASPT---QTVTLVTQPVVT--KETAISKLEMPSSLMLEVPALAD 1133
                   +A  +  I   P    + V   T  +++  +  + S  E  S L   +     
Sbjct: 1997 -------VARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQS 2049

Query: 1134 FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE---ELI 1190
               +   L   +  ++Q ++ ++V       I E +       QD+ +++  LE   E++
Sbjct: 2050 VQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMV 2109

Query: 1191 TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE 1250
            T       +T++     ++  ++  +  +++++    Q +   L ++L  +  +     +
Sbjct: 2110 TRFM----ETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGK 2165

Query: 1251 AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 1310
             +Q +      L S  +    +    ++I E   L  ++   Q N+D    L  +L    
Sbjct: 2166 LQQFMENKSRMLASGNQPDQDITHFFQQIQE---LNLEMEDQQENLDTLEHLVTELSSCG 2222

Query: 1311 SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 1370
             A D  +     +N+   +  + K V ERE         L +F   +  F  WL E E +
Sbjct: 2223 FALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGS 2282

Query: 1371 ANVLQDATRKERLLEDSKGVKELMKQWQD---LQGEIEAHTDVYHNL---------DENS 1418
                + +   + L +  + +K L+  W     L  EI        NL            +
Sbjct: 2283 IPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKT 2342

Query: 1419 QKILRSLEGS----------DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKR 1468
              IL S+  S           D   +Q  + ++N K+ +L       +  L+A  ++ + 
Sbjct: 2343 GSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEE 2402

Query: 1469 LHLSLQELLVWLQLKDDELSRQAPIGG--DFPAVQKQNDVHRAFKRELKTKEPVIMSTLE 1526
            +H     +L WL+ K++ L     +        V+ Q + ++AF  EL+   P I    E
Sbjct: 2403 VHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKE 2462

Query: 1527 TVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQR 1586
                      L GL   Y      P  + A+N     +K  EE+N+ WE+    +   QR
Sbjct: 2463 A---------LAGLLVTY------PNSQEAEN----WKKIQEELNSRWERATEVTVARQR 2503

Query: 1587 KIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID--SLQDHLEKVKALRGEI 1644
            +++E+   L   Q A  +L   L + E++ G    +G L ID   L    ++V+ +  E 
Sbjct: 2504 QLEESASHLACFQAAESQLRPWLMEKELMMG---VLGPLSIDPNMLNAQKQQVQFMLKEF 2560

Query: 1645 APLKENVSHVNDLARQLTT--LGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEA 1700
               ++    +N+ A+ + T    + LS   +   L+ +N +W  L   +  R  Q+ +A
Sbjct: 2561 EARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQA 2619



 Score =  139 bits (349), Expect = 4e-32
 Identities = 282/1654 (17%), Positives = 682/1654 (41%), Gaps = 187/1654 (11%)

Query: 107  QKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVN 166
            Q+ LQ +  +     K AN   +  ESK   +EV   + A+ + + + E V++Q      
Sbjct: 2390 QESLQAILNRMEEVHKEANSVLQWLESK---EEVLKSMDAMSSPT-KTETVKAQAESNKA 2445

Query: 167  LYKSLSEVKSEVEMVIKTGRQIV----QKKQTENPKELDERVTALKLHYNELGAKVTERK 222
                L +   +++ V +    ++      ++ EN K++ E + +      E+      R+
Sbjct: 2446 FLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEV---TVARQ 2502

Query: 223  QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 282
            +QLE+        +   + L  WL   ++ +     +   P+ L+++    +   KE E 
Sbjct: 2503 RQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEA 2562

Query: 283  QKVHLKSITEVGEALKTVLGK---KETLVEDKLSLLNSNWIAVT-------SRAEEWLNL 332
            ++   + + E  + + T  G      + V+ +L  +N  W+ +T       S+ ++ +  
Sbjct: 2563 RRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVK 2622

Query: 333  LLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDS 392
              +YQ+ ++   + V  + + +     +  + E  K Q +E     ++++L  +  +V  
Sbjct: 2623 STQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEET--SEIRSDLEQLDHEVKE 2680

Query: 393  TRDQAANLMANRG-----DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFN 446
             +     L    G     D  +K +E     L       + RI   +A++   ++ +Q  
Sbjct: 2681 AQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMF 2740

Query: 447  SDIQKLLE----------PLEAEIQ--QGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ 494
             +++  L+          P+ A+++  Q    + E+F K +N+ + G+ + ++  G++L 
Sbjct: 2741 DELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQ-HSGSYEVIVAEGESLL 2799

Query: 495  QRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDD 554
              +    ++  ++ +   L+     L    + R+ +  +   +  +Y+   +DL+  ++D
Sbjct: 2800 LSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED 2859

Query: 555  IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKR 614
             + K++ L    D     +++  L + K  LN V ++   L    +A  +     +  + 
Sbjct: 2860 CKAKMSELRVTLDP---VQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED 2916

Query: 615  WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL--LE 672
               I  + A   +   A    ++ +T  +  E+M   +     ++      V  A   LE
Sbjct: 2917 G--IRDEKAGINQNMDAVTEELQAKTGSL--EEMTQRLREFQESFKNIEKKVEGAKHQLE 2972

Query: 673  VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA---TPVE 729
            +   L +     K+ E L  Q+E L+ ++        ++D + +     ++ A   +   
Sbjct: 2973 IFDALGSQACSNKNLEKLRAQQEVLQALEP-------QVDYLRNFTQGLVEDAPDGSDAS 3025

Query: 730  RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIK-IFNQWLTEAEQFLRK 788
            ++  Q  ++Q +F   +V +         +  +E   +FH  ++ +F+Q     ++    
Sbjct: 3026 QLLHQAEVAQQEFL--EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGM 3083

Query: 789  TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEE---IIQQSSKTDASILQEKLG 845
              I  + +  + +  +++++  + +   +   + A+  E   ++++    D   L+ +L 
Sbjct: 3084 GAIGRDTDSLQSQ--IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELE 3141

Query: 846  SLNLRWQEVCKQLSDRKKRLEEQKNI----LSEFQRDL---NEFVLWLEEADNIASIPLE 898
            +LN +    C +L++R K  +EQ  +    + +F R L   N+     EEA+ +  +   
Sbjct: 3142 ALNKQ----CGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVV-- 3195

Query: 899  PGKEQQL-KEKLEQVKLLVEEL--PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLK 955
             G E ++  ++L   K+  +E   PL+   L+Q+N  G  ++ SA    + Q  LE+ ++
Sbjct: 3196 -GTEVEIINQQLADFKMFQKEQVDPLQMK-LQQVNGLGQGLIQSAGKDCDVQG-LEHDME 3252

Query: 956  QTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQ 1015
            + N +W  +++ + ++  +++  +   G+ +  LE L       L WL+     +     
Sbjct: 3253 EINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPL-------LSWLADTEELIANQKP 3305

Query: 1016 PNQEGPF---DVQETEIA---VQAKQPDVEEILSKGQHLYK--EKPATQPVKRKLEDLSS 1067
            P+ E       +QE ++    +  ++  V+ + ++G  + +  E    + +  +LE L S
Sbjct: 3306 PSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLES 3365

Query: 1068 EWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 1127
             W     LL +  A+Q  L   L                 V+ K+               
Sbjct: 3366 RW---TELLSKAAARQKQLEDIL-----------------VLAKQ--------------- 3390

Query: 1128 VPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE 1187
                  F+     ++D+LS+ ++ + +   +      I + II+ KA  +D+E     + 
Sbjct: 3391 ------FHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVH 3444

Query: 1188 ELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEA 1247
            + +   Q+L + TS  E + +++++I+ +Q ++ E+Q+    +   L++ L ++  + E 
Sbjct: 3445 QAVKIGQSLSSLTSPAE-QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED 3503

Query: 1248 KEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL 1307
            + E    L +   KL S     +  D + ++  +   L +++   + NVD A      LL
Sbjct: 3504 EVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALL 3563

Query: 1308 RDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEA 1367
            +  + ++   +    + I   +  I    S+    LE+  +L  +F    E+   WL E 
Sbjct: 3564 KQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREV 3623

Query: 1368 ETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL----- 1422
            E      ++           + + +  ++ ++L+ E+  H  V   ++E S+ +L     
Sbjct: 3624 E------EELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPW 3677

Query: 1423 RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL 1482
            R+ EG D  V       + N ++  +          ++A+  + ++   +    L W+  
Sbjct: 3678 RAREGLDKLV------SDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAE 3731

Query: 1483 KDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEK 1542
               +L    PI  +      Q  V +AF             +++ +R        + +++
Sbjct: 3732 TKRKLMALGPIRLEQDQTTAQLQVQKAF-------------SIDIIR------HKDSMDE 3772

Query: 1543 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 1602
            L+    E+      +  T +L+++ E +  ++E ++L +++   +++     + +  E  
Sbjct: 3773 LFSHRSEIFGTCGEEQKT-VLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETY 3831

Query: 1603 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 1662
            +EL   + +   +     P   +  + L+   E+++ LR  IA  K ++  +  +  QL 
Sbjct: 3832 EELSPWIEETRALIAQ-LPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLK 3890

Query: 1663 TLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 1696
                +L+P     +E+   + + +   +++ VRQ
Sbjct: 3891 ----ELNPEEGEMVEEKYQKAENMYAQIKEEVRQ 3920



 Score =  137 bits (344), Expect = 2e-31
 Identities = 325/1863 (17%), Positives = 723/1863 (38%), Gaps = 328/1863 (17%)

Query: 14   FLNAVRRQKLLEQSIQSAQETEKS--LHLIQESLTFID--------KQLAAYIADKVDA- 62
            +LN ++   ++ +SIQ A+   K   + L QE +   D          L  +++D  D  
Sbjct: 1152 YLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKN 1211

Query: 63   ----------AQMPQEAQKIQSDLTSHEISLEE-MKKHNQGKEAAQRVLSQIDVAQKKLQ 111
                      A+    A+++        + LE   +K +Q +E   RV++Q+++ Q +L+
Sbjct: 1212 SVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELE 1271

Query: 112  DVSMKFRLFQ----------KPANFEQRLQ-----ESKMILDEVKMHLPALETKSVEQEV 156
             +      ++          +    +Q +      E   +L E      AL     E E 
Sbjct: 1272 SIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTAL---FAEIER 1328

Query: 157  VQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE---------LDERVTAL 207
             Q++L+ C    +  S +  + E+ + T +  V+ +Q    K          + +    L
Sbjct: 1329 NQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDL 1388

Query: 208  KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 267
            +  Y  L    T+  + +   L   R++ +E  V+ E        + K   + G  S L 
Sbjct: 1389 RTRYTALVTLTTQHVKYISDAL---RRLEEEEKVVEE---EKQEHVEKVKELLGWVSTLA 1442

Query: 268  SEVAWGKATQKE------IEK----QKVHLKSIT----EVGEALKT-----------VLG 302
                 GKAT  E      IEK    Q+V  + +T    +V EA+KT           +  
Sbjct: 1443 RNTQ-GKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSE 1501

Query: 303  KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEY----------QKHMETFDQNVDHITK 352
            K++  + ++L+ LN  +  +   +   L  L             QK   T  Q ++ +  
Sbjct: 1502 KEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCS 1561

Query: 353  WIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMAN----RGDHC 408
            W+ QA+  L   + +  QQ    L++ +++L D++  + +     A ++ +      ++ 
Sbjct: 1562 WVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQ 1621

Query: 409  RKLVEPQISELNHRF--AAISHRIKTGKASIPLKELEQ-FNSDIQKLLEPLEAEIQQGVN 465
             KL   +++ L  +   A   +     +  +  KELE+   S +Q+  E  +A  +   N
Sbjct: 1622 TKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN 1681

Query: 466  LKEEDFNKDMNEDNEGTVKELLQR--------GDNLQQRITD------------------ 499
             K+ D   D       +  +LL          G +L++   D                  
Sbjct: 1682 KKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQ 1741

Query: 500  ----ERKREEIKIKQQ------------LLQTKHNALKDLRSQRRKKALEISHQWYQYKR 543
                + + +E+  +QQ            L Q  HN   + +   ++K  E+  Q+     
Sbjct: 1742 CEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLA 1801

Query: 544  QADDLLKCLDDIEKKLASLPEPRDERK--IKEIDRELQ------KKKEELNAVRRQAEGL 595
            Q++  LK +  ++ +L    +   E +  ++  ++EL+         E L ++ ++    
Sbjct: 1802 QSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSF 1861

Query: 596  SEDGAAMAVEPTQIQLS-KRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISY 654
            SED  +   +   + +S ++  ++E+ F + +    ++I  + ++ +   TE      + 
Sbjct: 1862 SEDVISHKGDLRFVTISGQKVLDMENSFKEGKEP--SEIGNLVKDKLKDATE----RYTA 1915

Query: 655  VPSTYLTEITHVSQALLEVEQLLNAPD-------LCAKDFEDLF------------KQEE 695
            + S      +H++  L +  Q  N+ D        C  + E L             +Q  
Sbjct: 1916 LHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLA 1975

Query: 696  SLKNIKDSLQQSSGRIDIIH--SKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKD 753
            + K +++ L +    ++ +   ++    ++     +   +QE    +   ++ ++    +
Sbjct: 1976 TTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAE 2035

Query: 754  RQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQ 813
            R     +++ + +     ++   Q + E EQ L   Q+             + L   +  
Sbjct: 2036 RSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQV----SSLSSGVIQEALATNMKL 2091

Query: 814  RQTVVR---TLNATGEEI---IQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEE 867
            +Q + R   +L AT E +   ++ +  T A++LQ KL  ++ R++++C Q  +++  L++
Sbjct: 2092 KQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKK 2151

Query: 868  QKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE-----QQLKEKLEQVKLLVEELPLR 922
                   F+    +   ++E    + +   +P ++     QQ++E   +++   E L   
Sbjct: 2152 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL 2211

Query: 923  QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 982
            + ++ +L+  G  + +      + QD+++N  K              E Q  ++ + KD 
Sbjct: 2212 EHLVTELSSCGFALDLC-----QHQDRVQNLRKD-----------FTELQKTVKEREKDA 2255

Query: 983  GQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEIL 1042
               +++L++  + +     WL      +     P  E     +E E  ++  +  +++  
Sbjct: 2256 SSCQEQLDEFRKLVRTFQKWLKETEGSI-----PPTETSMSAKELEKQIEHLKSLLDDWA 2310

Query: 1043 SKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPG--LTTIGAS---- 1096
            SKG                +E+++ +  ++  L+ E+ A       G  L ++G+S    
Sbjct: 2311 SKG--------------TLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSV 2356

Query: 1097 ----PTQTVTLVTQPVVTKETAISKL-----EMPSSLMLEVPALADFNRAWTELTDWLSL 1147
                  + +T +   +        KL     E   SL   +  + + ++    +  WL  
Sbjct: 2357 NGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLES 2416

Query: 1148 LDQVIKSQRVMVG--DLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEA 1205
             ++V+KS   M      E +       KA + +LEQ  P+++++  A   L         
Sbjct: 2417 KEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL--------- 2467

Query: 1206 RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESW 1265
              ++T    +    W ++QE L +R ++  E+     + LE           A ++L  W
Sbjct: 2468 --LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPW 2525

Query: 1266 ---KE------GPYTVD--AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR---DYS 1311
               KE      GP ++D   +  +  + + + K+    +   +  N+ A  +L    D S
Sbjct: 2526 LMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVS 2585

Query: 1312 ADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTA 1371
               T +V    ++IN  W  +  +++ R + +++                  + ++    
Sbjct: 2586 L-STSQVQKELQSINQKWVELTDKLNSRSSQIDQA-----------------IVKSTQYQ 2627

Query: 1372 NVLQDATRKERLLEDSKGVKE-LMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 1430
             +LQD + K R +     V+  +  Q + ++ ++E  +++  +L++   ++  +    D+
Sbjct: 2628 ELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDE 2687

Query: 1431 AVL----------LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWL 1480
              +          L++RL+ +      L   + +  + L+A+    ++      EL  WL
Sbjct: 2688 LSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWL 2747

Query: 1481 QLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGL 1540
              K  + ++  PI      +Q Q   +  F++ L         + E +         EG 
Sbjct: 2748 DDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHS----GSYEVI-------VAEGE 2796

Query: 1541 EKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 1600
              L   P   P EE+     R L+ Q  E+   WE+L+  +AD Q ++ + +++ Q+ Q 
Sbjct: 2797 SLLLSVP---PGEEK-----RTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW 2848

Query: 1601 ATDEL-----DLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVN 1655
              ++L     D K + +E ++ +  PV       L+  L + KA+  E+   +  +  +N
Sbjct: 2849 HVEDLVPWIEDCKAKMSE-LRVTLDPV------QLESSLLRSKAMLNEVEKRRSLLEILN 2901

Query: 1656 DLA 1658
              A
Sbjct: 2902 SAA 2904



 Score = 88.6 bits (218), Expect = 7e-17
 Identities = 209/1165 (17%), Positives = 451/1165 (38%), Gaps = 201/1165 (17%)

Query: 617  EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 676
            E+E+  A+F+ L  +  +  +EET+  M              Y++E+ ++   L E EQ 
Sbjct: 1021 EVEACKARFQHLMKSMENEDKEETVAKM--------------YISELKNIRLRLEEYEQR 1066

Query: 677  L--NAPDLCAKDFEDLFKQEESLK-----NIKDSLQQSSGRIDIIHSKKTAALQ-----S 724
            +      L +   +    Q+ +L+     + ++ LQQ    +D +  K  + L      S
Sbjct: 1067 VVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSS 1126

Query: 725  ATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQ 784
            + P  R +L   + ++D  +  ++ +Y ++    D  V   +     +K +   L++ E 
Sbjct: 1127 SVPTLRSELNLLVEKMDHVYG-LSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEV 1185

Query: 785  FLRKTQIPE-NWEHAKYKWYLKELQDGIGQRQTVVRTLN---ATGEEIIQQSSKT----- 835
             L      E +W   ++  +L +++D    + +V   L+   A  + + +Q S+      
Sbjct: 1186 VLADLSALEAHWSTLRH--WLSDVKD----KNSVFSVLDEEIAKAKVVAEQMSRLTPERN 1239

Query: 836  -DASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIAS 894
             D    QEK   L  RW  V  QL  R+  LE  + +L +++      + W+EE      
Sbjct: 1240 LDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQE 1299

Query: 895  IPLEPGKEQQ---LKEKLEQVKLLVEELPLRQGILKQLNETGGPV----------LVSAP 941
            + ++PG+ +    L E+L Q   L  E+   Q  L Q  +               L++  
Sbjct: 1300 M-MKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYK 1358

Query: 942  ISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA-------QIKDLGQLEKKLEDLE- 993
               E Q K   K ++       +++   + +    A        +K +    ++LE+ E 
Sbjct: 1359 AFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEK 1418

Query: 994  ----------EQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILS 1043
                      E++  LL W+S +          N +G     ET+ +   ++  +E+ + 
Sbjct: 1419 VVEEEKQEHVEKVKELLGWVSTLAR--------NTQGKATSSETKESTDIEKAILEQQVL 1470

Query: 1044 KGQHLYKEKPATQPVK----------RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1093
              +   K++  ++ +K           KL +   E K ++  L  L     DL  G    
Sbjct: 1471 SEELTTKKEQVSEAIKTSQIFLAKHGHKLSE--KEKKQISEQLNALNKAYHDLCDG---- 1524

Query: 1094 GASPTQTVTLVTQPV-VTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVI 1152
              S  Q   L +Q    T++  + K +      LE            +L  W+   ++ +
Sbjct: 1525 --SANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLE------------DLCSWVGQAERAL 1570

Query: 1153 KSQ--RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNL--KNKTS-NQEART 1207
                 R    DL  + +     K    D++ R      ++   +    +N+T  +    T
Sbjct: 1571 AGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELT 1630

Query: 1208 IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLES--- 1264
             + +++ + + Q++ +QE  +  +++L E +  + Q    K +A + L + + K+++   
Sbjct: 1631 ALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLD 1690

Query: 1265 W---------------------------------KEGPYTVDAIQKKITETKQLAK---- 1287
            W                                  +G   V+   +K+ +  ++ K    
Sbjct: 1691 WVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQ 1750

Query: 1288 DLRQWQTNVDVANDLALKLLRDYSADDT-RKVHMITENINASWRSIHKRVSEREAALEET 1346
            +L   Q N  +A   A   L  +  + T  +  M+ + +          +++ EA L++ 
Sbjct: 1751 ELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQV 1810

Query: 1347 HRL---LQQFPLDLEKFLAWLTEAE-TTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 1402
              L   LQ+F  D ++F +WL  +E    N+ +  +  E L         L+K+      
Sbjct: 1811 QTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETL-------PSLLKRQGSFSE 1863

Query: 1403 EIEAHTDVYHNLDENSQKIL-------RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 1455
            ++ +H      +  + QK+L          E S+   L++ +L +   +++ L  K   +
Sbjct: 1864 DVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRL 1923

Query: 1456 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAVQKQNDVHRAFKRE 1513
             SHL     Q+ +   S   L  W+Q  +  + +     +  D   +Q+Q    +  + E
Sbjct: 1924 GSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEE 1983

Query: 1514 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1573
            L                   + P+E L+K+ ++  E+  E    +  R +++  + + + 
Sbjct: 1984 LAEH----------------QVPVEKLQKVARDIMEIEGEPAPDH--RHVQETTDSILSH 2025

Query: 1574 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEV-IKGSWQPVGDLLIDSLQD 1632
            ++ L+   A+    + + + + Q +QE+ + L   + + E  ++G  + V  L    +Q+
Sbjct: 2026 FQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG--KQVSSLSSGVIQE 2083

Query: 1633 HLEKVKALRGEIAPLKENVSHVNDL 1657
             L     L+ +IA  K ++    ++
Sbjct: 2084 ALATNMKLKQDIARQKSSLEATREM 2108



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 155/922 (16%), Positives = 347/922 (37%), Gaps = 160/922 (17%)

Query: 20   RQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDL 76
            RQ  LE ++ +  + + +L  +   LT  ++ L A      D   +  E  K   +++D+
Sbjct: 4256 RQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDV 4315

Query: 77   TSHEISLEEMKK------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR--------LFQK 122
             +H+ ++E + K       +   + A  + S+++   +  + V  K            Q+
Sbjct: 4316 LAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQ 4375

Query: 123  PANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 182
               F   +++  + L  ++  L A +      E  + QL+  + LY  L   +     ++
Sbjct: 4376 AQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLL 4435

Query: 183  KTGR-QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNV 241
              GR  ++ +  + +  + ++ V  L+  ++ + +K+ ERK +LE+ L L+ + +  +  
Sbjct: 4436 DKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQE 4495

Query: 242  LTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 301
               WL   +  L   S    + + + S++   K    E+   +  +  + + G  LK + 
Sbjct: 4496 FINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLS 4555

Query: 302  GKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL 360
             K++  L+++ L  + S W  V  R+                            I+    
Sbjct: 4556 QKQDVVLIKNLLVSVQSRWEKVVQRS----------------------------IERGRS 4587

Query: 361  LDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELN 420
            LD++ +K+ +Q  +  K+L   L D    +DS  +     ++N  D              
Sbjct: 4588 LDDA-RKRAKQFHEAWKKLIDWLEDAESHLDSELE-----ISNDPD-------------- 4627

Query: 421  HRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNE 480
                         K  + L + ++F   +       +  I+ G  LKE+    + ++  +
Sbjct: 4628 -------------KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLD 4674

Query: 481  GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQW-Y 539
              + E+  + D +  +  + + + E  +              L S +   AL+    W Y
Sbjct: 4675 NFLGEVRDKWDTVCGKSVERQHKLEEAL--------------LFSGQFMDALQALVDWLY 4720

Query: 540  QYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDG 599
            + + Q  +      D++  +  +    D  K+    +EL K+   +  ++R    L E+ 
Sbjct: 4721 KVEPQLAEDQPVHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRELIENS 4774

Query: 600  A--AMAVEPTQIQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMPLEISY 654
                  V+    +LS RW  + +   ++  RL  A  Q    R+   M++      E + 
Sbjct: 4775 RDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTL 4834

Query: 655  VPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDII 714
                 L + T   Q+L++  +            E + K EE   ++  ++      + + 
Sbjct: 4835 RFRGALPDDTEALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEVILAVC 4882

Query: 715  HSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI 774
            H      ++    + R + +E L+     W K        Q R + ++ +       ++ 
Sbjct: 4883 HPDCITTIKHWITIIRARFEEVLT-----WAK------QHQQRLETALSELVANAELLEE 4931

Query: 775  FNQWLTEAEQFLRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTLN---- 822
               W+  AE  L +     IP+N +  K     ++ +++E+         V +T      
Sbjct: 4932 LLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI 4991

Query: 823  ------------ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLSDRKKR 864
                        + G + + Q +     IL +      ++  L+ RWQ+V     +R+++
Sbjct: 4992 EPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRK 5051

Query: 865  LEEQKNILSEFQRDLN-EFVLW 885
            L +  + L E +   N +F +W
Sbjct: 5052 LNDALDRLEELKEFANFDFDVW 5073



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 187/989 (18%), Positives = 373/989 (37%), Gaps = 189/989 (19%)

Query: 748  NKMYKDRQGRFDRSVEK----WRRFHYDIKIFNQWLTEAEQFLRKT-QIPENWEHAKYKW 802
            NK   +   R ++S +K    W + H + K    W      +LRK   + + W   K + 
Sbjct: 926  NKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISW-----NYLRKDLDLVQTWNLEKLR- 979

Query: 803  YLKELQDGIGQRQTVVRTLNATGEEIIQQS------SKTDASILQEKLGSLNLRWQEVCK 856
                     G+   +++ L A  E+ +Q S      S  D   L+E++ +   R+Q + K
Sbjct: 980  -----SSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMK 1034

Query: 857  QLSDRKKR-------LEEQKNI---LSEFQRDLNEFV-----------LWLEEADNIASI 895
             + +  K        + E KNI   L E+++ + + +            W + A  IA  
Sbjct: 1035 SMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQ 1094

Query: 896  PLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVS-APISPEEQDKLE--- 951
                   QQL+  L+ V +  +       + +  + +  P L S   +  E+ D +    
Sbjct: 1095 EHTQEDLQQLRSDLDAVSMKCDSF-----LHQSPSSSSVPTLRSELNLLVEKMDHVYGLS 1149

Query: 952  ----NKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLED---LEEQLNHLLLWLS 1004
                NKLK  ++    + R++ + +  ++     L Q E  L D   LE   + L  WLS
Sbjct: 1150 TVYLNKLKTVDV----IVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLS 1205

Query: 1005 PIRNQLEIYNQPNQE---GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRK 1061
             ++++  +++  ++E        ++       +  D+E    KG  L +       V  +
Sbjct: 1206 DVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQER---WHRVIAQ 1262

Query: 1062 LEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMP 1121
            LE   SE +++  +L + RA    L   +           T   Q ++    A     + 
Sbjct: 1263 LEIRQSELESIQEVLGDYRACHGTLIKWIEE---------TTAQQEMMKPGQAEDSRVLS 1313

Query: 1122 SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 1181
              L  +    A+  R  T+       LDQ  K  +     ++D    ++  KA ++  ++
Sbjct: 1314 EQLSQQTALFAEIERNQTK-------LDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQK 1366

Query: 1182 RRPQLEELITAAQNLKNKTSNQEAR-----TIITDRIERIQN---QWDEVQEHLQNRRQQ 1233
               +   +++++  +  +  +   R     T+ T  ++ I +   + +E ++ ++  +Q+
Sbjct: 1367 SPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQE 1426

Query: 1234 LNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 1293
              E +K+   W+           Q +A     KE       I+K I E + L+++L   +
Sbjct: 1427 HVEKVKELLGWVSTLARNT----QGKATSSETKES----TDIEKAILEQQVLSEELTTKK 1478

Query: 1294 TNVDVANDLALKLLRDYSAD-DTRKVHMITENINASWRSIHK---------RVSEREAAL 1343
              V  A   +   L  +      ++   I+E +NA  ++ H          +  + + A 
Sbjct: 1479 EQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAH 1538

Query: 1344 EETHRLLQQ----FPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD 1399
            +   + LQ+        LE   +W+ +AE      Q  T ++ L    K   +L    +D
Sbjct: 1539 QTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDL----KD 1594

Query: 1400 LQGEIEAHTDVYHNLDENSQKILRSLEG---SDDAVLLQRRLDNMNFKWSELRKKSLNIR 1456
            LQ +I+       N   +   +++ +EG    +   L  R L       + LR+K    +
Sbjct: 1595 LQDDIQ-------NRATSFATVVKDIEGFMEENQTKLSPREL-------TALREKLHQAK 1640

Query: 1457 SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 1516
               EA  ++ +     L+E +                     A+Q++ +  +A K   + 
Sbjct: 1641 EQYEALQEETRVAQKELEEAVT-------------------SALQQETEKSKAAKELAEN 1681

Query: 1517 KEPV------IMSTLETVRIFLTEQPLEGLEKL---------------YQEPRELPPEER 1555
            K+ +      + S   +    LT  P  G+E+L               Y    + P  E+
Sbjct: 1682 KKKIDALLDWVTSVGSSGGQLLTNLP--GMEQLSGASLEKGALDTTDGYMGVNQAP--EK 1737

Query: 1556 AQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE-----TLERLQELQEATDEL----D 1606
                  +++ + +E+ ++ +   L +   Q  +D+     T E  Q LQ+   EL     
Sbjct: 1738 LDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYS 1797

Query: 1607 LKLRQAEVIKGSWQPVGDLLIDSLQDHLE 1635
              L Q+E      Q + D L   LQDH E
Sbjct: 1798 TSLAQSEAELKQVQTLQDELQKFLQDHKE 1826


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score =  248 bits (632), Expect = 7e-65
 Identities = 348/1764 (19%), Positives = 734/1764 (41%), Gaps = 167/1764 (9%)

Query: 15   LNAVRRQ--KLLEQSIQSAQETEKSLHLIQESLTFIDK-QLAAYIADKVDAAQMP--QEA 69
            L A+ +Q  KLL+++    ++ E ++  ++E  + + +  +    A++ + +Q P   E 
Sbjct: 3198 LEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMET 3257

Query: 70   QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR 118
            + I   L   ++  +E  +  QGK+     L Q  I  A K          L DV+ +++
Sbjct: 3258 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWK 3317

Query: 119  -LFQKPANFEQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNH 163
             L +K A    +LQE+ +     +  L +L              +  S E +VV++Q+  
Sbjct: 3318 TLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQE 3377

Query: 164  CVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQ 223
               L + L + KS VE++ + G +I    +  +  ++ ++++ L   +  L  K   R +
Sbjct: 3378 QKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNR 3437

Query: 224  QLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQ 283
            QLE    ++++  + +  L EWL   +  L     +    S L+ ++A  KA + +I   
Sbjct: 3438 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3497

Query: 284  KVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 342
              HL     +G++LK +  +++  +V+ KL      +I +  ++     LL +   + + 
Sbjct: 3498 NKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKI 3557

Query: 343  FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 402
            F ++   +  W+ +    L  S+        + L + ++EL  ++  +   +      + 
Sbjct: 3558 FGEDEVELMNWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALL 3615

Query: 403  NRGDHCRKLVEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL-------- 452
            N  +  ++    ++  +  +  AI  R K  T  ++   K LEQ     ++L        
Sbjct: 3616 NGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3675

Query: 453  --LEPLEAEI--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDE 500
              L+ +E E+   +   LK E+ +      K++ ++  N   + + L    +    +   
Sbjct: 3676 TWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPW 3735

Query: 501  RKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLA 560
            R RE ++        ++  + D  +Q+ ++      +  Q+ + AD  L  + + EKKL 
Sbjct: 3736 RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLM 3795

Query: 561  SLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIES 620
            SL + R E+   +   +LQ +K     + R  + +  D    +        S+  ++   
Sbjct: 3796 SLGDIRLEQD--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMK 3851

Query: 621  KFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAP 680
            K       N+  I  +  E  + +     L ++    TY      +   L E + +++  
Sbjct: 3852 KKLDKVLKNYDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQL 3906

Query: 681  DLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQL 740
               A ++E L +Q+E  + +++ + +    ID ++ K    L   +P E   +QE     
Sbjct: 3907 PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAA 3965

Query: 741  DFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHA 798
            D  + ++ +  K R    D ++ +  +FH  I   +Q L   E+ + + + P +   E  
Sbjct: 3966 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVE 4022

Query: 799  KYKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRW 851
            K K  + E ++    + + Q +  TL   GEE+I +S  TD  I    +Q+KL  +   W
Sbjct: 4023 KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIW 4082

Query: 852  QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLE 910
            + +   + +R+ +L +   +  +F  D    ++ +++  +      +PG +  + K++ E
Sbjct: 4083 ENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQE 4142

Query: 911  QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRAL 968
              + + EE+   Q  L  +   G  ++ +      E DK  ++  + + N  W  +++A 
Sbjct: 4143 AAETIREEIDGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAW 4198

Query: 969  PEKQGEIEAQIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQ 1025
             ++  ++E  ++   Q +  L+   D  +     L  +SPI   LE   Q  +E    ++
Sbjct: 4199 KDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LK 4254

Query: 1026 ETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD 1085
            + +     +Q ++E +  + + L K K   +  K  ++D   E K +   L+E       
Sbjct: 4255 QFKSEAYQQQIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER------ 4307

Query: 1086 LAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWL 1145
                                  ++ ++    KLE   +L+    AL  F  A  EL  WL
Sbjct: 4308 ----------------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWL 4336

Query: 1146 SLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEA 1205
            +  + ++  Q+ + GD + I   + K      D+   +  +E +  A  +L   ++ +EA
Sbjct: 4337 THTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEA 4396

Query: 1206 RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESW 1265
              +  +++E +  +W  V E  + R+QQL+  L+ +  +    E+ +Q L      L + 
Sbjct: 4397 SNL-QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLAS 4455

Query: 1266 KEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENI 1325
            K      +  ++++    ++       +           ++L          +     N+
Sbjct: 4456 KPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNL 4515

Query: 1326 NASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLE 1385
               W S+  +++ER+  LEE   L  +F   L+ F+ WLT+AE T NV   A+R   +L+
Sbjct: 4516 KEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILD 4572

Query: 1386 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 1445
                V   + + +    E+ +H +    LD+     L+      D VL++  L ++  +W
Sbjct: 4573 T---VLFQIDEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRW 4628

Query: 1446 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 1505
             ++ ++ +     L+ +  + K+ H +  +L+ WL+  +  L  +  I  D   ++ Q  
Sbjct: 4629 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4688

Query: 1506 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 1565
             H+ F++ L  K  V  +T  T                    R L  +    +    L  
Sbjct: 4689 QHKEFQKSLGAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDD 4729

Query: 1566 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GD 1624
               E+  +W+ +   S + Q K++E L    +  +A   L   L + E      QPV GD
Sbjct: 4730 MLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD 4789

Query: 1625 LLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWK 1684
              ID + + ++  KA + E+     +V  +   AR+L       S +    +++L+TRW+
Sbjct: 4790 --IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWE 4847

Query: 1685 LL-------QVAVEDRVRQLHEAH 1701
             +       Q  +E  +RQ  E H
Sbjct: 4848 TVCALSISKQTRLEAALRQAEEFH 4871



 Score =  216 bits (549), Expect = 3e-55
 Identities = 302/1617 (18%), Positives = 647/1617 (40%), Gaps = 189/1617 (11%)

Query: 97   QRVLSQIDVAQKKLQDVSMKFRLFQK---PAN-----FEQRLQESKMILDEV-KMHLPAL 147
            + +L++ +   ++L+ +S+  + F +   P N      E+RL   + I  +  K+     
Sbjct: 3426 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3485

Query: 148  ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTAL 207
            + K++E +++    NH  +L++++S  +S   +  +  + +VQ K           +   
Sbjct: 3486 QHKALEDDII----NHNKHLHQAVSIGQSLKVLSSREDKDMVQSK-----------LDFS 3530

Query: 208  KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 267
            ++ Y E+  K   R + L++ L  ++   ++   L  WL     +L+K S  +     L 
Sbjct: 3531 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3590

Query: 268  SEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 326
             + +  +  Q++I  +K ++      G E LK   G +  +++DKL  + + +  +T  +
Sbjct: 3591 KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3650

Query: 327  EEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDVL---KRLKA 381
             +    L +  +         + +  W+  ++ + L  E++  K ++        K LK 
Sbjct: 3651 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3710

Query: 382  ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI--KTGKASIPL 439
            E  + +  +DS  + ++ L+       R+ +E  ++E N R+  +S  I  K  +    +
Sbjct: 3711 EAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3770

Query: 440  KELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED---NEGTVKE 485
               +QF+              +KL+   +  ++Q     +    K    +   ++  + +
Sbjct: 3771 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDD 3830

Query: 486  LLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQA 545
            L++ G  +    ++E K + +K K   +   ++ +  + S+R  +         Q+    
Sbjct: 3831 LVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETY 3889

Query: 546  DDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEELNAVRRQAEG 594
            ++L   L + +  ++ LP P            + R+++E+  E +   +++N    Q   
Sbjct: 3890 EELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 3949

Query: 595  LSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISY 654
            LS  G   +++   +     + +I+      ++   A    + + T      D  LE   
Sbjct: 3950 LSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDKIDQILESLE 4005

Query: 655  VPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDII 714
                 L +   +S  + ++++ ++     + D E L    E+LK   + +   SG  D  
Sbjct: 4006 RIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4065

Query: 715  HSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI 774
             S K              +Q+ L Q+ F WE ++ + ++R+ +    +E   +F  D   
Sbjct: 4066 ISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMS 4112

Query: 775  FNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGE 826
                + + + F+R  + P        +  E A+    ++E  DG+ +   +V  L   G 
Sbjct: 4113 LIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDIVINL---GS 4166

Query: 827  EIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWL 886
            E+I    + D  I+++ +  LN  W  + K   DR  +LEE      ++Q  L     W+
Sbjct: 4167 ELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWV 4226

Query: 887  EEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPE 945
            + A   +AS+       + +K+++E++K    E   +Q  +++LN     +L       E
Sbjct: 4227 DIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT---E 4283

Query: 946  EQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 1003
            E DK  +++ L +  L W  +   +  +Q ++E  +  LGQ +  L++L       L WL
Sbjct: 4284 ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-------LAWL 4336

Query: 1004 SPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQHLYKEKPAT 1055
            +     L    Q    G     E E+A        V A Q  VE +   G  L +     
Sbjct: 4337 THTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGE 4394

Query: 1056 QP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKET 1113
            +   ++ KLE L+  W+ V                                      ++T
Sbjct: 4395 EASNLQNKLEVLNQRWQNV-------------------------------------LEKT 4417

Query: 1114 AISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK 1173
               K ++  +L         F+    +L  WL+  ++ + + + + G  E   E +    
Sbjct: 4418 EQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM 4473

Query: 1174 ATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 1233
                  E +    + L+   Q +  +   + A T I   I  ++ +W+ V+  L  R+ +
Sbjct: 4474 EVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVETKLNERKTK 4532

Query: 1234 LNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 1293
            L E L  + ++  + ++    L QA   L         +D +  +I E K  A ++   +
Sbjct: 4533 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHR 4592

Query: 1294 TNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQF 1353
              +   +     L       D   +  +  ++ + W  + +R+ ER  +L++  +  +QF
Sbjct: 4593 EQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQF 4652

Query: 1354 PLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHN 1413
                 K + WL E+E + +       +  +  D   +K  + Q ++ Q  + A   VY  
Sbjct: 4653 HEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDT 4706

Query: 1414 LDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSL 1473
             +   + +      +DD + L   L  +  KW  +  KS+  ++ LE +     +   +L
Sbjct: 4707 TNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4766

Query: 1474 QELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLT 1533
            Q L+ WL   + +L+   P+ GD   V    D H+AF++EL  +                
Sbjct: 4767 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT--------------- 4811

Query: 1534 EQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLE 1593
                  ++ L +  REL   E +++ +  ++ Q +E++T WE +   S   Q +++  L 
Sbjct: 4812 ----SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALR 4865

Query: 1594 RLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVKALRGEI 1644
            + +E       L   L +AE        + D       LID  ++ ++K++  R E+
Sbjct: 4866 QAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAEL 4922



 Score =  212 bits (540), Expect = 3e-54
 Identities = 302/1584 (19%), Positives = 628/1584 (39%), Gaps = 175/1584 (11%)

Query: 102  QIDVAQKKLQDVSMKFRLFQKPAN-----FEQRLQESKMI----------LDEVKMHLPA 146
            ++ + Q KL+ +  +++   K +       EQ LQ ++ +          LD+V++ L +
Sbjct: 3628 EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLS 3687

Query: 147  LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTA 206
             ET+ ++ E           L K     K+ ++ + +    +++       + L++ V  
Sbjct: 3688 YETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE 3747

Query: 207  LKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNL 266
                Y  +   +T++ ++++  +  S++  +  +    W+  T+ +L     +       
Sbjct: 3748 DNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT 3807

Query: 267  DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSR 325
             +++   K    EI + K  +  + + G  + T   ++E   ++ KL  +  N+  +   
Sbjct: 3808 SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQI 3867

Query: 326  AEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD-------ESEKKKPQQKED-VLK 377
              E    L   Q  +  F +  + +  W+ +  +++        E E  + QQ+E   L+
Sbjct: 3868 NSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLR 3927

Query: 378  RLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASI 437
             L AE      K++ T  Q   L    G      ++ +    +  ++ I   +K    ++
Sbjct: 3928 ELIAEHKPHIDKMNKTGPQLLELSPGEGFS----IQEKYVAADTLYSQIKEDVKKRAVAL 3983

Query: 438  P--LKELEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTV------- 483
               + +  QF+  I ++LE LE  +++      ++ + E   + ++E+   +V       
Sbjct: 3984 DEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQP 4043

Query: 484  --KELLQRGDNLQQRITDERKREEIKIKQQLLQTK---HNALKDLRSQRRKKALEISHQW 538
              + L QRG+ +  R     K    K  Q  L         +  L  +R  K L++    
Sbjct: 4044 LYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4103

Query: 539  YQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKKEELNAVRRQAE---G 594
             ++      L+  + D +  +  L +P  D   +K+     +  +EE++ ++ + +    
Sbjct: 4104 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVIN 4163

Query: 595  LSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISY 654
            L  +  A   EP +  + K   E+ S +    +    +I  + EE M    +        
Sbjct: 4164 LGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL-EEAMQAAVQ-------- 4214

Query: 655  VPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDII 714
                Y   +  V   +      L +      D E + +Q E LK  K    Q    ++ +
Sbjct: 4215 ----YQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERL 4270

Query: 715  HSKKTAALQSATPV-ERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 773
            + +    L+  T   ++  +Q+ L +L   W+ + +   +RQ + + ++    +F + + 
Sbjct: 4271 NHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4330

Query: 774  IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQ 830
                WLT  E  L + Q P   +    +  L +   LQ+ +   Q+ V  +N  G ++I+
Sbjct: 4331 ELLAWLTHTEGLLSE-QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIE 4389

Query: 831  QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 890
             S+  +AS LQ KL  LN RWQ V ++   RK++L+        F  ++ +   WL + +
Sbjct: 4390 SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTE 4449

Query: 891  N--IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQ- 947
               +AS PL  G  +  KE+L     +      ++   K L + G  +L   P S E   
Sbjct: 4450 RHLLASKPLG-GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4508

Query: 948  DKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIR 1007
            D+  N LK+   +W  V   L E++ ++E  +    +    L+D        + WL+   
Sbjct: 4509 DQDINNLKE---KWESVETKLNERKTKLEEALNLAMEFHNSLQDF-------INWLTQAE 4558

Query: 1008 NQLEIYNQPN---QEGPFDVQETEI---AVQAKQPDVEEILSKGQHL--YKEKPATQPVK 1059
              L + ++P+       F + E ++    V + +  + E+   G HL  + +K     +K
Sbjct: 4559 QTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK 4618

Query: 1060 RKLEDLSSEW-KAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKL 1118
              L  + S W K V RL++  R                                      
Sbjct: 4619 NLLISVQSRWEKVVQRLVERGR-------------------------------------- 4640

Query: 1119 EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD 1178
                SL         F+ AW++L +WL   ++ + S+  +  D + I   + + K   + 
Sbjct: 4641 ----SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKS 4696

Query: 1179 LEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEML 1238
            L  +    +      ++LK KTS  +    + D +  ++++WD +      R+ +L E L
Sbjct: 4697 LGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEAL 4756

Query: 1239 KDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDV 1298
              S Q+ +A +     L +   +L   +     +D +   I   K   K+L +  ++V  
Sbjct: 4757 LFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQA 4816

Query: 1299 ANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLE 1358
                A +L+   S DD+  V +  + ++  W ++      ++  LE   R  ++F   + 
Sbjct: 4817 LKRSARELIEG-SRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVH 4875

Query: 1359 KFLAWLTEAETTAN---VLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLD 1415
              L WL EAE T     VL D     R L D    KE MK+ ++ + E+   T +   + 
Sbjct: 4876 ALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQH--KEFMKKLEEKRAELNKATTMGDTV- 4932

Query: 1416 ENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE 1475
                    ++   D    ++  +  +  ++ E+   +   +  L ++          L+ 
Sbjct: 4933 -------LAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEA 4985

Query: 1476 LLVWLQLKDDELSRQAP--IGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVR---- 1529
            LL WLQ  +  L+ +    I  +   V+     H+ F  E+  K+P +    +T +    
Sbjct: 4986 LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAA 5045

Query: 1530 --------IFLTEQPLEGLEK-----LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 1576
                    I + ++   G ++     LY    +   E +   V  L+ K        W++
Sbjct: 5046 DPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSK--------WQQ 5097

Query: 1577 LNLHSADWQRKIDETLERLQELQE 1600
            + L + + +RK+++ L+RL+EL+E
Sbjct: 5098 VWLLALERRRKLNDALDRLEELRE 5121



 Score =  206 bits (525), Expect = 2e-52
 Identities = 321/1772 (18%), Positives = 710/1772 (40%), Gaps = 195/1772 (11%)

Query: 22   KLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEI 81
            K L Q +    E   S     E++T   K+      +     Q  +E   I   L S   
Sbjct: 2980 KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAY 3039

Query: 82   SLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF--------------RLFQKPANFE 127
            S + +      +++ Q +  Q+D+A++  QD+ ++                + Q+ +   
Sbjct: 3040 SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS 3099

Query: 128  QRLQESKMILD---------------------EVKMHLPALETKSVEQEVVQSQLNHCVN 166
            Q++ E    L+                     E    L ++     + E +Q Q      
Sbjct: 3100 QQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKA 3159

Query: 167  LYKSLSEVKSEVEMVIKTGRQIVQKKQTE-NPKELDERVTALKLHYNELGAKVTERKQQL 225
              K L  + +  +   KT + ++  ++T  +   +   + AL    N+L  +   R++Q+
Sbjct: 3160 FLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3219

Query: 226  EKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQK-EIEKQK 284
            E  +K   +   ++   +  L   +     +  V      ++ ++   K  QK EIE  +
Sbjct: 3220 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3279

Query: 285  VHLKSITEVGEALKTVLGKKETL--VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 342
               + +  +G+ L     K  +   +E  L  +N+ W  +  +  +    L E   H   
Sbjct: 3280 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3339

Query: 343  FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 402
            F   ++ +  W++  + L+  + +K P  +  V+K    E   ++  +D  R     ++ 
Sbjct: 3340 FQDALESLLSWMVDTEELV--ANQKPPSAEFKVVKAQIQEQKLLQRLLDD-RKSTVEVIK 3396

Query: 403  NRGDHCRKLVEP--------QISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 454
              G+      EP        Q+S L+ R+ A+ ++ +T       ++LE  +   Q+  E
Sbjct: 3397 REGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN-----RQLEGISVVAQQFHE 3451

Query: 455  PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK--REEIKIKQQL 512
             LE   +    +++   N +        ++E + +   L+  I +  K   + + I Q L
Sbjct: 3452 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL 3511

Query: 513  LQTKHNALKDLRSQRRKKALEISHQWY-QYKRQADDLLKCLDDIEKKLASLPEPRDERKI 571
                    KD+   +    L+ S  WY + + ++    + L           E  DE ++
Sbjct: 3512 KVLSSREDKDMVQSK----LDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGE--DEVEL 3565

Query: 572  KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 631
                 E+  K  +L+      EGL +  + + V    I L K  + ++        LN  
Sbjct: 3566 MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK--QNVDQAL-----LNGL 3618

Query: 632  QI--HTVREETMMVMTEDMPLEISYVPSTYL-TEITHVSQALLEVEQLLNA--PDLCA-- 684
            ++   T  +E +++  +   ++  Y   T L T++    +  L++ + L++   +LC   
Sbjct: 3619 ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWL 3678

Query: 685  -------KDFE-DLFKQEESL------KNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 730
                     +E  + K EE+       K +K   + +   +D ++   +A L+      R
Sbjct: 3679 DKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAR 3738

Query: 731  VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK-- 788
              L++ +++ + ++  V+     +    D ++ + ++F         W+TE E+ L    
Sbjct: 3739 EGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLG 3798

Query: 789  -TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSL 847
              ++ ++   A+ +   K     I + + ++  L  +G +I+   S+ +   +++KL  +
Sbjct: 3799 DIRLEQDQTSAQLQ-VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKV 3857

Query: 848  NLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIAS-IPLEPGKEQQLK 906
               +  +C+  S+R  +LE  ++++++F     E   WL E  +I S +P    + + L+
Sbjct: 3858 LKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLR 3917

Query: 907  EKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSR 966
            ++ E+ + L E +   +  + ++N+TG  +L    +SP E   ++ K    +  + ++  
Sbjct: 3918 QQQEEHRQLRELIAEHKPHIDKMNKTGPQLL---ELSPGEGFSIQEKYVAADTLYSQIKE 3974

Query: 967  ALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL-SPIRNQLEIYNQPNQEGPFDVQ 1025
             + ++   ++  I    Q   K++ + E L  ++  L  P     E+  +  +E   + +
Sbjct: 3975 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEV--EKIKEQISENK 4032

Query: 1026 ETEIAVQAKQPDVEEILSKGQHLYKEKPAT------QPVKRKLEDLSSEWKAVNRLLQEL 1079
               + ++  QP  E +  +G+ +      T      + V+ KL+ +   W+ ++ L++E 
Sbjct: 4033 NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEER 4092

Query: 1080 RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 1139
             AK                                          +L+V  LA+  + W 
Sbjct: 4093 EAK------------------------------------------LLDVMELAE--KFW- 4107

Query: 1140 ELTDWLSLLDQVIKSQRVMVGDLED--INEMIIK-QKATMQDLEQRRPQLEELITAAQNL 1196
               D +SL+   IK  +  + DLED  I+  ++K Q+   + + +    L+E +    NL
Sbjct: 4108 --CDHMSLI-VTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 4164

Query: 1197 KNK---TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 1253
             ++      +  + I+   I+ + + WD + +  ++R  +L E ++ + Q+ +  +    
Sbjct: 4165 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 4224

Query: 1254 VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 1313
             +  A  KL S       ++ ++++I E KQ   +  Q Q  ++  N  A  LL+  + +
Sbjct: 4225 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4284

Query: 1314 -DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN 1372
             D   V      +   W S+ +R+  R+  LE     L QF   L++ LAWLT  E    
Sbjct: 4285 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL-- 4342

Query: 1373 VLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAV 1432
                 + ++ +  D K ++  + +   LQ ++ AH      +++    ++ S  G ++A 
Sbjct: 4343 ----LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG-EEAS 4397

Query: 1433 LLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP 1492
             LQ +L+ +N +W  + +K+   +  L+ +  Q K  H  +++L  WL   +  L    P
Sbjct: 4398 NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKP 4457

Query: 1493 IGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP 1552
            +GG     ++Q +VH       + KE    S ++  +  L   P      + Q+   L  
Sbjct: 4458 LGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNL-- 4515

Query: 1553 EERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQA 1612
                                +WE +     + + K++E L    E   +  +    L QA
Sbjct: 4516 ------------------KEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQA 4557

Query: 1613 E-VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPY 1671
            E  +  + +P   L++D++   +++ K    E+   +E +  ++     L     +    
Sbjct: 4558 EQTLNVASRP--SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4615

Query: 1672 NL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 1702
             + + L  + +RW+ +   + +R R L +A +
Sbjct: 4616 LIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4647



 Score =  198 bits (503), Expect = 6e-50
 Identities = 343/1820 (18%), Positives = 730/1820 (40%), Gaps = 205/1820 (11%)

Query: 24   LEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE---AQKIQSDLTSHE 80
            ++Q+I  + + +  L  + + L+ +D +L++ +A       M Q+   AQK++ ++   +
Sbjct: 2674 IDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEK 2733

Query: 81   ISL---------------EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN 125
              +               EE  K    ++    + S  DV QK    V            
Sbjct: 2734 KQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2793

Query: 126  FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTG 185
            F+Q  ++ +  LD  K         S + +V++S +    +  K+L+      E  I  G
Sbjct: 2794 FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEG 2853

Query: 186  RQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEW 245
              ++ K Q      L  ++  +K +++    +V ER+ +L++ L+ + K ++++  L  W
Sbjct: 2854 ENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2913

Query: 246  LAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKK 304
            +      L + +  ++  P+  ++ +A  K+ QKE+++    ++ +     +L +V    
Sbjct: 2914 IDKCQNNLEEIKFCLD--PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2971

Query: 305  ETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDES 364
            + +V D+   L      VT +       L    +  + F +      + +  A   LD  
Sbjct: 2972 KEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH 3031

Query: 365  EKKKPQQKED----VLKRLKAELNDIRPKVDSTRDQAANLMANRGD-HCRKLVEPQISEL 419
            +    Q   +    +L+  +  L  ++ +VD  +  A +L+    D      V  Q+  +
Sbjct: 3032 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETI 3091

Query: 420  NHRFAAISHRI--KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNE 477
                + +S ++  K       L+ +  F + I+++         +  ++     + +  +
Sbjct: 3092 AQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQ 3151

Query: 478  DNEGTVKELLQR-------GDNLQQR-----ITDERKREEIKIKQQL--LQTKHNALKDL 523
              + T+K  L++        DN  +       T+E   + + IK+ L  L  + N L D 
Sbjct: 3152 KQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLD- 3210

Query: 524  RSQRRKKALEIS----HQWYQYKRQADDLLKCLDDIEK-------KLASLPEPRDERKI- 571
            R+Q R++ +E +     ++Y   ++   LL+  ++ E+       +  ++ +  +  K+ 
Sbjct: 3211 RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVF 3270

Query: 572  -KEIDRELQKKKEELNAVRRQAEGLSEDGA----AMAVEPTQIQLSKRWREIESKFAQ-F 625
             KE    LQ K++++N +    +GL +  A       +E     ++ RW+ +  K AQ  
Sbjct: 3271 QKEEIEPLQGKQQDVNWL---GQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRA 3327

Query: 626  RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 685
             +L  A +H  R                     +   +  +   +++ E+L+      + 
Sbjct: 3328 AQLQEALLHCGR---------------------FQDALESLLSWMVDTEELVANQKPPSA 3366

Query: 686  DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 745
            +F+ +  Q +  K ++  L      +++I  +      +A P ++VK+ + LS LD +WE
Sbjct: 3367 EFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWE 3426

Query: 746  KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL- 804
             +    + R  + +      ++FH  ++  N+WLT  E+ L   + P   + +K +  + 
Sbjct: 3427 ALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE-PIGTQASKLEEQIA 3485

Query: 805  --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 862
              K L+D I      +    + G+ +   SS+ D  ++Q KL    + + E+ ++   R 
Sbjct: 3486 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3545

Query: 863  KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIPLEPGKEQQLKEKLEQVKLLVEELPL 921
            + L++       F  D  E + WL E  D ++ + ++    + L ++  ++++L E++ L
Sbjct: 3546 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3605

Query: 922  R-----QGILKQL----NETGGPVLV------SAPISPEEQDKLENKLKQTNLQWIKVSR 966
            R     Q +L  L      TG  VL+      +     ++  KL   + +T  Q ++++R
Sbjct: 3606 RKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3665

Query: 967  ALPEKQGEI--------------EAQI-------------KDLGQLEKKLEDLEEQLNHL 999
             L     E+              E Q+             K+L +  K  + L + LN +
Sbjct: 3666 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEV 3725

Query: 1000 ---LLWLSP--IRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPA 1054
               LL L P   R  LE     + E    V +T   +  K  +++  + + Q   +   A
Sbjct: 3726 SSALLELVPWRAREGLEKMVAEDNERYRLVSDT---ITQKVEEIDAAILRSQQFDQAADA 3782

Query: 1055 -------TQPVKRKLEDLSSEWKAVNRLLQELRA------KQPDLAPGL--------TTI 1093
                   T+     L D+  E    +  LQ  +       +  D+   L        T  
Sbjct: 3783 ELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3842

Query: 1094 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW---TELTDWLSLLDQ 1150
                 Q++      V+     I ++     L LE  A +  N+ W    EL  WL+    
Sbjct: 3843 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE-RAQSLVNQFWETYEELWPWLTETQS 3901

Query: 1151 VIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIIT 1210
            +I        + E + +   + +   + + + +P ++++      L   +  +     I 
Sbjct: 3902 IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS--IQ 3959

Query: 1211 DRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP- 1269
            ++       + +++E ++ R   L+E +  STQ+    ++ +Q+L      +E  ++ P 
Sbjct: 3960 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQF---HDKIDQILESLERIVERLRQPPS 4016

Query: 1270 --YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL-RDYSADDTRKVHMITENIN 1326
                V+ I+++I+E K ++ D+ + Q   +       +++ R    D       + + ++
Sbjct: 4017 ISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLD 4076

Query: 1327 AS---WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 1383
                 W +IH  V EREA L +   L ++F  D    +  + + +     L+D      +
Sbjct: 4077 QMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSV 4136

Query: 1384 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 1443
            ++  +   E ++  +++ G ++   D+  NL       L +  G  D  ++++ +D +N 
Sbjct: 4137 VKQQQEAAETIR--EEIDG-LQEELDIVINLGSE----LIAACGEPDKPIVKKSIDELNS 4189

Query: 1444 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 1503
             W  L K   +    LE +     +    LQ +  W+ +   +L+  +PIG D   V++Q
Sbjct: 4190 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4249

Query: 1504 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 1563
             +  + FK E                    +Q +E +E+L  +   L  +   ++    +
Sbjct: 4250 IEELKQFKSE------------------AYQQQIE-MERLNHQAELLLKKVTEESDKHTV 4290

Query: 1564 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 1623
            +    E+   W+ L     + Q K++  L  L + Q A DEL   L   E +    +PVG
Sbjct: 4291 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4350

Query: 1624 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTR 1682
                 +++  L K   L+ ++   +  V  VN     L          NL + LE LN R
Sbjct: 4351 G-DPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4409

Query: 1683 WKLLQVAVEDRVRQLHEAHR 1702
            W+ +    E R +QL  A R
Sbjct: 4410 WQNVLEKTEQRKQQLDGALR 4429



 Score =  191 bits (486), Expect = 6e-48
 Identities = 304/1643 (18%), Positives = 676/1643 (41%), Gaps = 168/1643 (10%)

Query: 36   KSLHLIQESLTFIDKQLAAYIADKVDA---AQMPQEAQKIQSDLTSHEISLEEMKKH-NQ 91
            ++L   +E++    K+L A +A   +A    +M    ++   DL   +  LE + K  N+
Sbjct: 3148 ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK 3207

Query: 92   GKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKS 151
              + AQ    Q++   K+L++             F  +L+E  ++L + + H  +     
Sbjct: 3208 LLDRAQAREEQVEGTIKRLEE-------------FYSKLKEFSILLQKAEEHEESQGPVG 3254

Query: 152  VEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTALKL 209
            +E E +  QLN      K  +  ++ + + V   G+ ++Q   ++ + + L+  +  +  
Sbjct: 3255 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3314

Query: 210  HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 269
             +  L  KV +R  QL++ L    + +  +  L  W+  T+  +  +         + ++
Sbjct: 3315 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQ 3374

Query: 270  VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEE 328
            +   K  Q+ ++ +K  ++ I   GE + T     + + +  +LSLL+S W A+ ++AE 
Sbjct: 3375 IQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAET 3434

Query: 329  WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELNDI 386
                L       + F + ++ + +W+   +  L   E    Q    E+ + + KA  +DI
Sbjct: 3435 RNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDI 3494

Query: 387  RPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 441
                          Q+  ++++R D  + +V+ ++      F+ + + I+  + S    E
Sbjct: 3495 INHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSRSE 3546

Query: 442  LEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRITD 499
            L Q      K+    E E+   +N   +  +K   +D   EG  K+        + R+  
Sbjct: 3547 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRVLQ 3600

Query: 500  ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL 559
            E   + +  KQ + Q   N L+ L+     + L I  +    K +  D+ K   D+ K L
Sbjct: 3601 E---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3657

Query: 560  ASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWRE 617
                +    R++     EL     K E+  +  + + L  + A+ A +    +L K  + 
Sbjct: 3658 EQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEAKN 3714

Query: 618  IESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 673
             ++       ++ A +  V    RE    ++ ED       V  T   ++  +  A+L  
Sbjct: 3715 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAILRS 3773

Query: 674  EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV-- 731
            +Q   A D       +  K+  SL +I+    Q+S ++ +  +     L+    ++ +  
Sbjct: 3774 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3833

Query: 732  ---KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ--------- 777
               K+  A S+ + Q   +K++K+ K+       + E++ +      + NQ         
Sbjct: 3834 SGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELW 3893

Query: 778  -WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK 834
             WLTE +  + +   P  E     + +   ++L++ I + +  +  +N TG ++++ S  
Sbjct: 3894 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3953

Query: 835  TDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADNIA 893
               SI QEK  + +  + ++ + +  R   L+E  +  ++F   +++ +  LE   + + 
Sbjct: 3954 EGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4012

Query: 894  SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDKLE 951
              P    + +++KE++ + K +  ++   Q + + L + G  ++  +  + ++     ++
Sbjct: 4013 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4072

Query: 952  NKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIRNQ 1009
            +KL Q    W  +   + E+    EA++ D+ +L +K        +H  L++ +   ++ 
Sbjct: 4073 DKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQDF 4123

Query: 1010 LEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVKRK 1061
            +     P  +     Q+ E A      +   Q +++ +++ G  L     +P    VK+ 
Sbjct: 4124 IRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS 4183

Query: 1062 LEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMP 1121
            +++L+S W ++N+  ++                                    I KLE  
Sbjct: 4184 IDELNSAWDSLNKAWKD-----------------------------------RIDKLEEA 4208

Query: 1122 SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 1181
                  + A   +      + DW+ +    + S   +  DLE + + I + K    +  Q
Sbjct: 4209 ------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4262

Query: 1182 RRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDS 1241
            ++ ++E L   A+ L  K + +  +  + D +  ++  WD ++E + NR+ +L   L   
Sbjct: 4263 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4322

Query: 1242 TQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVAND 1301
             Q+  A +E    L      L   K       AI+ ++ +   L  D+   Q+ V+  N 
Sbjct: 4323 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4382

Query: 1302 LALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFL 1361
                L+   + ++   +    E +N  W+++ ++  +R+  L+   R  + F  ++E   
Sbjct: 4383 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQ 4442

Query: 1362 AWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKI 1421
             WLT+ E      +     + L    +  KE +    ++    EA  + Y +L +  Q++
Sbjct: 4443 QWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQM 4496

Query: 1422 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 1481
            L     S +   + + ++N+  KW  +  K    ++ LE + +     H SLQ+ + WL 
Sbjct: 4497 LARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4555

Query: 1482 LKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQPLE 1538
              +  L+  +        V  Q D H+ F  E+ +    I+   +T   ++ F  +Q + 
Sbjct: 4556 QAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4615

Query: 1539 GLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQRKI 1588
             ++ L      +  + R + V + L          RK+A++ +  W KL     +W  + 
Sbjct: 4616 LIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLEES 4666

Query: 1589 DETLERLQELQEATDELDLKLRQ 1611
            +++L+   E+    D++  +L Q
Sbjct: 4667 EKSLDSELEIANDPDKIKTQLAQ 4689



 Score =  176 bits (447), Expect = 2e-43
 Identities = 370/1827 (20%), Positives = 735/1827 (40%), Gaps = 273/1827 (14%)

Query: 21   QKLLEQSIQSAQETEKSL-HLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSH 79
            QK ++ S Q+  E  K+  + ++E+   + ++  A I  K++ A++  E   ++++ +  
Sbjct: 1633 QKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKK 1692

Query: 80   EISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDE 139
            E+   +       KE  ++V +   + + K +  ++   L     + E+   + K ++++
Sbjct: 1693 EL---DKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQ 1749

Query: 140  VKMHLPALETKSV---EQEVVQSQLNHCV---------NLYKSLSEVKSEVEMVIKTGRQ 187
               H    + KS    E EV  + L   V         NL +   +VK++ E +I   + 
Sbjct: 1750 NGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQA 1809

Query: 188  IVQKKQT--------------ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS- 232
            ++   Q+              E  ++L + +  LK+HY E     +E+K +L   L+   
Sbjct: 1810 VIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHY-ETALAESEKKMKLTHSLQEEL 1868

Query: 233  RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 292
             K   +      WL  ++ EL    A     + L +++   K+  +++   K  L+ IT 
Sbjct: 1869 EKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITI 1928

Query: 293  VG----EALKTVL----GKKETL-----VEDKLSLLNSNWIAVTSRAEEWLN----LLLE 335
             G    EA K+      GK +T      V+ KL      + ++ S+     N    L+ +
Sbjct: 1929 SGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK 1988

Query: 336  YQKHMETFDQNVDHITKWIIQADTLLDES---EKKKPQQKEDVLKRLKAELNDIRPKVDS 392
            YQ + +     +  +      A   L E    + K  Q++ +  K L+ +++  +  V+ 
Sbjct: 1989 YQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEK 2048

Query: 393  TRDQAANLMANRGD--HCRKLVEPQISELNHRFAAISHRIK------------------- 431
             +  A  L+  RG     +  ++  + ++  R+  +S  +                    
Sbjct: 2049 LKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDG 2108

Query: 432  -------TGKASIPLKELEQF---NSDIQKLLEP---LEAEI---QQGVNLKEEDFNKDM 475
                    G     LKE  Q    ++ +Q ++     LE +I   Q  +N   E   K M
Sbjct: 2109 LDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFM 2168

Query: 476  NEDNEGTVKELLQRGDNLQQRITD-ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEI 534
               +  T   L  +  +L  R ++   K +E   K + L+TK    ++L S++ +  LE 
Sbjct: 2169 ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL-SEKLQTFLET 2227

Query: 535  SHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQ--A 592
              Q           L  +D   K +  L +   E   + +  E +K  E L+++ ++  +
Sbjct: 2228 KTQ----------ALTEVDVPGKDVTELSQYMQESTSEFL--EHKKHLEVLHSLLKEISS 2275

Query: 593  EGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEI 652
             GL  D  A+ +E T   LSK+++E+E               T++E+   V +    L+ 
Sbjct: 2276 HGLPSD-KALVLEKTN-NLSKKFKEMED--------------TIKEKKEAVTSCQEQLDA 2319

Query: 653  SYVPSTYLTE-ITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEE--SLKNIKDSLQQSSG 709
              V    L   I   ++ +  V+    A DL  K  ED  K +E  SLK  +     +SG
Sbjct: 2320 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDL-GKSLEDTKKLQEKWSLKTPEIQKVNNSG 2378

Query: 710  RIDIIH--------SKKTAALQS----------ATPVER-------VKLQEALSQLDFQW 744
             I + +        +K  AA++S          AT  E          +++ ++ +   +
Sbjct: 2379 -ISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2437

Query: 745  EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK---TQIPENWEHAKYK 801
            E +  + KD+    +  + K ++   +     QWL +  +   K   T  P + E  K +
Sbjct: 2438 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2497

Query: 802  -WYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKT-DASILQEKLGSLNLRWQEVCKQLS 859
                K  +  + Q    V+ L     E+++++  T +A   ++ L  ++ +WQE+ +   
Sbjct: 2498 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2557

Query: 860  DRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASI--PLEPGKEQQLKEKLEQVKLLVE 917
            DR+++LEE  N L++FQ    +   WL E + + S+  PL       L  + +QV++L++
Sbjct: 2558 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQ 2616

Query: 918  ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 977
            E   R+   +QL   G  +L      P  +  ++ +L     +W  ++  L ++   I+ 
Sbjct: 2617 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2676

Query: 978  QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPD 1037
             I    Q +  L  L ++L+ L   LS   + L +   P+       Q+ E A + KQ  
Sbjct: 2677 AIVKSTQYQSLLRSLSDKLSDLDNKLS---SSLAVSTHPDAMN----QQLETAQKMKQEI 2729

Query: 1038 VEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGA 1095
             +E   +   Q L ++  A    +    +LS + + + +  +++  K  +    L +  A
Sbjct: 2730 QQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACA 2789

Query: 1096 SPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 1155
            S  Q                                  F +   +   WL    +     
Sbjct: 2790 SSHQ----------------------------------FQQMSRDFQAWLDTKKEEQNKS 2815

Query: 1156 RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIER 1215
              +   L+ +  +I   K   + L  +    E+ I   +NL  KT   E +  +  ++  
Sbjct: 2816 HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSE-KAALQLQLNT 2874

Query: 1216 IQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 1275
            I+  WD   + ++ R  +L E L+ + ++ E  E     + + +  LE  K   + +D  
Sbjct: 2875 IKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIK---FCLDPA 2931

Query: 1276 --QKKITETKQLAKDLRQWQTNVDVANDLALKLL------RDYSADDTR----KVHMITE 1323
              +  I + K L K++ Q    V++ N+ A  LL      ++   D+ +    KV M+TE
Sbjct: 2932 EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE 2991

Query: 1324 NINAS---WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 1380
             +++      ++ ++  E +   +E+ R LQ     L+               + D+   
Sbjct: 2992 QLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD---------------IHDSLGS 3036

Query: 1381 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDN 1440
            +     +K +  L  Q + LQ  ++   D+   L ++        +G+ D +L   +++ 
Sbjct: 3037 QAY--SNKYLTMLQTQQKSLQA-LKHQVDLAKRLAQDLVVEASDSKGTSDVLL---QVET 3090

Query: 1441 MNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAV 1500
            +  + S L ++     S LE           +++E+       DDEL   AP+G D   +
Sbjct: 3091 IAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETL 3150

Query: 1501 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 1560
            QKQ +  +AF ++L+       +  +T ++ L                    EE + ++ 
Sbjct: 3151 QKQKETIKAFLKKLEALMASNDNANKTCKMMLA------------------TEETSPDLV 3192

Query: 1561 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 1620
              +++  E ++ +  KL   +   + +++ T++RL+E      E  + L++AE  + S  
Sbjct: 3193 G-IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQG 3251

Query: 1621 PVGDLLIDSLQDHLEKVKAL-RGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST---- 1675
            PVG +  +++   L   K   + EI PL+     VN L + L    IQ +  + ST    
Sbjct: 3252 PVG-METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL----IQSAAKSTSTQGLE 3306

Query: 1676 --LEDLNTRWKLLQVAVEDRVRQLHEA 1700
              L+D+N RWK L   V  R  QL EA
Sbjct: 3307 HDLDDVNARWKTLNKKVAQRAAQLQEA 3333



 Score =  161 bits (407), Expect = 8e-39
 Identities = 282/1447 (19%), Positives = 579/1447 (40%), Gaps = 202/1447 (13%)

Query: 33   ETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS-HEISLEEMKKHNQ 91
            ETEK L  + +     D+  A     K    ++ +    I   + S H+I     ++  Q
Sbjct: 3789 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ 3848

Query: 92   G-KEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN-FEQRLQESKMILDEVKMHLPALET 149
              K+   +VL   D   +   +  ++    Q   N F +  +E    L E +  +  L  
Sbjct: 3849 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3908

Query: 150  KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 209
             ++E E ++ Q      L + ++E K  ++ + KTG Q+++    E    + E+  A   
Sbjct: 3909 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG-FSIQEKYVAADT 3967

Query: 210  HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 269
             Y+++   V +R   L++ +  S +   +++ + E L      L +  ++      +  +
Sbjct: 3968 LYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 4027

Query: 270  VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-----LVEDKLSLLNSNWIAVTS 324
            ++  K    ++EK +   +++ + GE +    G  +       V+DKL  +   W  + +
Sbjct: 4028 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4087

Query: 325  RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP-------QQKEDVLK 377
              EE    LL+  +  E F    DH++  +   DT     + + P       +Q+++  +
Sbjct: 4088 LVEEREAKLLDVMELAEKFW--CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4145

Query: 378  RLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT--GKA 435
             ++ E++ ++ ++D   +  + L+A  G+  + +V+  I ELN  + +++   K    K 
Sbjct: 4146 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4205

Query: 436  SIPLKELEQFNSDIQKL--------------------LEPLEAEIQQGVNLKEEDFNKDM 475
               ++   Q+   +Q +                    LE ++ +I++    K E + + +
Sbjct: 4206 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4265

Query: 476  NEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEIS 535
                   ++ L  + + L +++T+E  +  ++     L+   ++L++    R+ K     
Sbjct: 4266 E------MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGAL 4319

Query: 536  HQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEID--------RELQKKKEELNA 587
                Q++   D+LL  L   E  L+       + K  EI+         ++   +  + A
Sbjct: 4320 LALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEA 4379

Query: 588  VRRQAEGLSEDGAAMAVEPTQIQL---SKRWREIESKFAQFRR-----LNFAQ-IHTVRE 638
            V +    L E  A       Q +L   ++RW+ +  K  Q ++     L  A+  H   E
Sbjct: 4380 VNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIE 4439

Query: 639  ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 698
            +    +T+     ++  P   L E           EQL    ++CA  FE    +EE+ K
Sbjct: 4440 DLQQWLTDTERHLLASKPLGGLPETAK--------EQLNVHMEVCAA-FE---AKEETYK 4487

Query: 699  NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 758
            ++    QQ   R       K+A            + + ++ L  +WE V     +R+ + 
Sbjct: 4488 SLMQKGQQMLARCP-----KSA---------ETNIDQDINNLKEKWESVETKLNERKTKL 4533

Query: 759  DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPEN------WEHAKYKWYLKELQDGIG 812
            + ++     FH  ++ F  WLT+AEQ L     P        ++  ++K +  E+     
Sbjct: 4534 EEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS--- 4590

Query: 813  QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 872
             R+ ++  L+ TG  +   S K D  +++  L S+  RW++V ++L +R + L++ +   
Sbjct: 4591 HREQIIE-LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRA 4649

Query: 873  SEFQRDLNEFVLWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNE 931
             +F    ++ + WLEE++      LE   +  ++K +L Q K   + L  +  +    N 
Sbjct: 4650 KQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4709

Query: 932  TGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLED 991
            TG  +     ++ ++  KL++ L +   +W  +     E+Q ++E  +   GQ    L+ 
Sbjct: 4710 TGRSLKEKTSLA-DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQA 4768

Query: 992  LEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE 1051
            L +       WL  +  QL   +QP   G  D+    I       D  +   K   L K 
Sbjct: 4769 LID-------WLYRVEPQLA-EDQP-VHGDIDLVMNLI-------DNHKAFQK--ELGKR 4810

Query: 1052 KPATQPVKRKLEDL------SSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 1105
              + Q +KR   +L       S W  V   +QEL  +                +TV  ++
Sbjct: 4811 TSSVQALKRSARELIEGSRDDSSWVKVQ--MQELSTRW---------------ETVCALS 4853

Query: 1106 QPVVTK-ETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 1164
                T+ E A+ + E             +F+     L +WL+  +Q ++   V+  D + 
Sbjct: 4854 ISKQTRLEAALRQAE-------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4900

Query: 1165 INEMIIKQKATMQDLEQRRPQLEELITAAQNL------KNKTSNQEARTIITDRIERIQN 1218
            +  +I + K  M+ LE++R +L +  T    +       + T+ +   TII  R E +  
Sbjct: 4901 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 4960

Query: 1219 QWDEVQEHLQN------RRQQLNEMLKDSTQWLEAK-------------EEAEQVLGQAR 1259
               + Q+ L +       +Q+L E L    QW E               EE + ++ + +
Sbjct: 4961 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 5020

Query: 1260 AKLESWKEGPYTVDAIQKKITET-KQLAKDLRQWQTNVDV-----ANDLALKLLRDYSAD 1313
              +E        VD    K+T+T K+ A D    Q+++ V     A          Y + 
Sbjct: 5021 TFMEEMTRKQPDVD----KVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5076

Query: 1314 DTRKVHMITENIN---ASWRSIHKRVSEREAALEETHRLLQQ------FPLDL--EKFLA 1362
               ++      +N   + W+ +     ER   L +    L++      F  D+  +K++ 
Sbjct: 5077 SQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMR 5136

Query: 1363 WLTEAET 1369
            W+   ++
Sbjct: 5137 WMNHKKS 5143



 Score =  159 bits (401), Expect = 4e-38
 Identities = 321/1720 (18%), Positives = 690/1720 (40%), Gaps = 221/1720 (12%)

Query: 30   SAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKH 89
            S++E       + E+L  I   LA +  DK+   +  +  +++++   S+ +   E  K 
Sbjct: 1506 SSEEISTKKEQLSEALQTIQLFLAKH-GDKMTDEERNELEKQVKTLQESYNLLFSESLKQ 1564

Query: 90   NQGKEAAQRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRL---QESKMILDEVKMHLP 145
             Q  + +  V  +  +  ++ Q+   K + +       E RL   QE+ MI D   + L 
Sbjct: 1565 LQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGT-VELK 1623

Query: 146  ALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVT 205
              ++K   QE +Q  +       ++L+EV    E  +K   +   K   E+   +++++ 
Sbjct: 1624 KYQSK---QEELQKDMQGSA---QALAEVVKNTENFLKENGE---KLSQEDKALIEQKLN 1674

Query: 206  ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 265
              K+   +L  K  + K++L+K +  + K        TE +AA       ++ +E +   
Sbjct: 1675 EAKIKCEQLNLKAEQSKKELDKVVTTAIKEE------TEKVAAVKQLEESKTKIENL--- 1725

Query: 266  LDSEVAWGKATQKEIEKQKV-HLKSITEVGEALKTVLGKKETLVEDKLS--LLNSNWIAV 322
                + W     K+ E+    H + I + G   +   GK     ED+++  LL ++    
Sbjct: 1726 ----LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQ 1781

Query: 323  TSRAEEWLNLLLEYQKHMETFDQNVDHITKWII---QADTLLD-ESEKKKPQQKEDVLKR 378
                +E  NL  +YQK     ++ +      II    A  LL+ + +   P++KE + K 
Sbjct: 1782 VGTTQE--NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN 1839

Query: 379  LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP 438
            +K    +++   ++   ++   M          ++ ++ + +  +    H ++  +    
Sbjct: 1840 MK----ELKVHYETALAESEKKMK-----LTHSLQEELEKFDADYTEFEHWLQQSEQE-- 1888

Query: 439  LKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRIT 498
            L+ LE    DI  L+  L+         +++ F++D+   ++G ++ +   G+ + +   
Sbjct: 1889 LENLEAGADDINGLMTKLK---------RQKSFSEDVIS-HKGDLRYITISGNRVLEAAK 1938

Query: 499  DERKREEIKIK--------QQLLQTKHNALKDLRSQRR---KKALEISHQWYQYKRQADD 547
               KR+  K+         Q+ L    +  + L S+         ++  ++  Y+  +  
Sbjct: 1939 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1998

Query: 548  LLKCLDDIEKKLAS-LPEP---------RDERKIKEIDRELQKKKEELNAVRRQAEGLSE 597
            LL  L   E   +  L EP         R   + K +  ++  ++  +  +++ AE L +
Sbjct: 1999 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 2058

Query: 598  DGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPS 657
              A  ++ P +  + K   +I  ++    +     ++   E+  + +T  + ++      
Sbjct: 2059 --ARGSLLPAKNDIQKTLDDIVGRYEDLSK----SVNERNEKLQITLTRSLSVQDGL--D 2110

Query: 658  TYLTEITHVSQALLEVEQL-LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 716
              L  + +V  +L E  Q+ LN+  L     +D+  +   L+      Q S   I+ ++ 
Sbjct: 2111 EMLDWMGNVESSLKEQGQVPLNSTAL-----QDIISKNIMLEQDIAGRQSS---INAMNE 2162

Query: 717  KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFN 776
            K    +++  P     LQ  +  L  ++ + +  +K+   + +    K   F    +   
Sbjct: 2163 KVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQ 2222

Query: 777  QWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD 836
             +L    Q L +  +P   +  +   Y++E      + +  +  L++  +EI      +D
Sbjct: 2223 TFLETKTQALTEVDVPGK-DVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSD 2281

Query: 837  ASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIP 896
             +++ EK  +L+ +++E+   + ++K+ +   +  L  FQ  +     W++E      I 
Sbjct: 2282 KALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIV 2341

Query: 897  LEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV--LVSAPISPEEQDKL---- 950
                  + L + LE  K L E+  L+   ++++N +G  +  L+SA  +P +        
Sbjct: 2342 QPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSG 2401

Query: 951  ------ENKLKQTNLQWI-KVSRALPEKQGEIEAQIKDLGQLEK-----------KLEDL 992
                  E     T   W  K   ++ +   +I    +DLG L K           KL+  
Sbjct: 2402 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2461

Query: 993  EEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP----------DVEEIL 1042
            +E+ + ++ WL  +      + Q     P D +  +  V+  +            V+E+ 
Sbjct: 2462 QEESSAMMQWLQKMNKTATKWQQT--PAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELK 2519

Query: 1043 SKGQHLYKEKPATQPV---KRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 1099
             K   L +E P T      K+ L ++ S+W+ +N+L  + + K  + +  LT       Q
Sbjct: 2520 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQ 2579

Query: 1100 TVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMV 1159
                + Q +V KE  +S L                          LS+   ++ +QR  V
Sbjct: 2580 ----LKQWLVEKELMVSVLGP------------------------LSIDPNMLNTQRQQV 2611

Query: 1160 GDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEA-RTIITDRIERIQN 1218
                         +  +Q+   R+PQ E+L  A Q + ++     + R I+ +++  +  
Sbjct: 2612 -------------QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQ 2658

Query: 1219 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 1278
            +WD +   L +R   +++ +  STQ+          L     KL S        DA+ ++
Sbjct: 2659 KWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQ 2718

Query: 1279 ITETKQLAKDLRQWQTNVDVA----NDLALKLLRDY-SADDTRKVHMITENINASWRSIH 1333
            +   +++ ++++Q +  + VA     DL+  +  +Y  A+ +R++  I ++     +   
Sbjct: 2719 LETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAE 2778

Query: 1334 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1393
              V   ++A   +H+  QQ   D   F AWL   +   N     + K  +LE       L
Sbjct: 2779 NHVQHLQSACASSHQ-FQQMSRD---FQAWLDTKKEEQNKSHPISAKLDVLE------SL 2828

Query: 1394 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1453
            +K  +D    + A + +Y       + +L   +GS+ A  LQ +L+ +   W    K+  
Sbjct: 2829 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA-LQLQLNTIKTNWDTFNKQVK 2887

Query: 1454 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR----QAPIGGD-----FPAVQKQN 1504
               + L+ S ++  +    ++ L  W+    + L        P  G+       ++QK+ 
Sbjct: 2888 ERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEM 2947

Query: 1505 DVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERA-QNVTRLL 1563
            D H      L      ++S  E  +  +T++    ++K+     +L  ++   +N+T+  
Sbjct: 2948 DQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 3007

Query: 1564 RKQAEEVNTEWEKLNLHSADWQRKIDETL-------ERLQELQEATDELDLKLRQAEVIK 1616
             K+ +EV+ E  K  L  A  Q  I ++L       + L  LQ     L     Q ++ K
Sbjct: 3008 -KEFQEVSKE-SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAK 3065

Query: 1617 GSWQPVGDLLIDS-----LQDHLEKVKALRGEIAPLKENV 1651
               Q   DL++++       D L +V+ +  E + L + V
Sbjct: 3066 RLAQ---DLVVEASDSKGTSDVLLQVETIAQEHSTLSQQV 3102



 Score =  149 bits (376), Expect = 3e-35
 Identities = 324/1747 (18%), Positives = 698/1747 (39%), Gaps = 230/1747 (13%)

Query: 50   KQLAAYIA-DKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-EAAQRVLSQIDVAQ 107
            K L+  IA D  +  +  +E + +Q  ++S ++++E++KK  +   +A   +L   +  Q
Sbjct: 2012 KHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 2071

Query: 108  KKLQDVSMKFRLFQKPAN-----FEQRLQESKMI---LDEVKMHLPALETKSVEQEVV-- 157
            K L D+  ++    K  N      +  L  S  +   LDE+   +  +E+   EQ  V  
Sbjct: 2072 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2131

Query: 158  -----QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYN 212
                 Q  ++  + L + ++  +S +  + +  ++ ++         L  ++  L   ++
Sbjct: 2132 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFS 2191

Query: 213  ELG-------AKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 265
            E         AK+ E K ++E    LS K++  +   T+  A T++++  +   E +   
Sbjct: 2192 EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ--ALTEVDVPGKDVTE-LSQY 2248

Query: 266  LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSR 325
            +    +     +K +E     LK I+  G      L   + LV +K + L+  +  +   
Sbjct: 2249 MQESTSEFLEHKKHLEVLHSLLKEISSHG------LPSDKALVLEKTNNLSKKFKEMEDT 2302

Query: 326  AEEWLNLLLEYQKHMETFDQNVDHITKW---------IIQ----ADTLLDESEKKKPQQK 372
             +E    +   Q+ ++ F   V  +  W         I+Q    A+ L    E  K  Q+
Sbjct: 2303 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2362

Query: 373  EDVLKRLKAE--------LNDIRPKV-------------------DSTRDQAANLMANRG 405
            +  LK  + +        L ++   V                   + T        AN+G
Sbjct: 2363 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2422

Query: 406  ---------------DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDI 449
                           +    L++ +I+ELN + + +    +   A +  L+++ +  +  
Sbjct: 2423 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2482

Query: 450  QKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIK 509
            Q+   P + E  +    + + F  ++ + N   V+EL  +   L +   D  +    K  
Sbjct: 2483 QQTPAPTDTEAVKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQM 2541

Query: 510  QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDE 568
               + +K   L  L   R++K  E S+   Q++     L + L + E  ++ L P   D 
Sbjct: 2542 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP 2601

Query: 569  RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 628
              +    +++Q   +E    + Q E L+  G  +   P +          +       + 
Sbjct: 2602 NMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGE----------DPSLRGIVKE 2651

Query: 629  NFAQIHTVREETMMVMTEDMP--LEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAK 685
              A + T + +++     D    ++ + V ST Y + +  +S  L +++  L++    + 
Sbjct: 2652 QLAAV-TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST 2710

Query: 686  DFEDLFKQEESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQ 743
              + + +Q E+ + +K  +QQ   +I +  +  +  +AL        VK +   ++L  Q
Sbjct: 2711 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQ 2762

Query: 744  WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 803
             E + K +KD + + +  V+  +        F Q   + + +L   +  +N  H      
Sbjct: 2763 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHP-ISAK 2821

Query: 804  LKELQDGIGQRQTVVRTLNAT----------GEEIIQQSSKTDASILQEKLGSLNLRWQE 853
            L  L+  I   +   +TL A           GE ++ ++  ++ + LQ +L ++   W  
Sbjct: 2822 LDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDT 2881

Query: 854  VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLE 910
              KQ+ +R+ +L+E      +++  +     W+++  +N+  I   L+P + +    KL 
Sbjct: 2882 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKL- 2940

Query: 911  QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPE 970
              K L +E+    G+++ LN T   +L    I  E     ENK                 
Sbjct: 2941 --KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK----------------- 2980

Query: 971  KQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA 1030
                          L +K++ + EQL+     L  +  + + + + ++E      + ++ 
Sbjct: 2981 -------------SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES-----KRQLQ 3022

Query: 1031 VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 1090
               +Q D+ + L    +  K     Q  ++ L+ L  +     RL Q+L  +  D     
Sbjct: 3023 CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD----- 3077

Query: 1091 TTIGASPTQTVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLL 1148
                +  T  V L  + +  + + +S+   E  S L  ++  +  F     E+    +  
Sbjct: 3078 ----SKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEF 3133

Query: 1149 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 1208
            D  + S   +  D E +     KQK T++   ++   LE L+ +  N  NKT      T 
Sbjct: 3134 DDELDSMAPVGRDAETLQ----KQKETIKAFLKK---LEALMASNDNA-NKTCKMMLATE 3185

Query: 1209 ITDR--------IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 1260
             T          +E +  Q +++ +  Q R +Q+   +K   ++    +E   +L +A  
Sbjct: 3186 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 3245

Query: 1261 KLESWKEGPYTVDAIQKKITETKQLAKD-LRQWQTNVDVANDLALKLLRDYS-ADDTRKV 1318
              ES        + I +++   K   K+ +   Q      N L   L++  + +  T+ +
Sbjct: 3246 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3305

Query: 1319 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 1378
                +++NA W++++K+V++R A L+E      +F   LE  L+W+ + E        A 
Sbjct: 3306 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----AN 3360

Query: 1379 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 1438
            +K    E  K VK  +++ + LQ  ++        +    +KI  + E +D   +L ++L
Sbjct: 3361 QKPPSAE-FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQL 3418

Query: 1439 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFP 1498
              ++ +W  L  K+      LE  S   ++ H +L+ L  WL   +  L    PIG    
Sbjct: 3419 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3478

Query: 1499 AVQKQNDVHRAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPE 1553
             +++Q   H+A + ++      +   +S  +++++  + +  + ++    + +   +  +
Sbjct: 3479 KLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3538

Query: 1554 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLK 1608
            E++ + + LL++         E   +   +W  ++ + L +L     +T+ L     +L+
Sbjct: 3539 EKSHSRSELLQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR 3597

Query: 1609 LRQAEVIKGSWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHV 1654
            + Q +++    Q V   L++ L              QD LE +KA   +I  L  +V+  
Sbjct: 3598 VLQEDILLRK-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3656

Query: 1655 NDLARQL 1661
             + A QL
Sbjct: 3657 LEQALQL 3663



 Score = 92.4 bits (228), Expect = 5e-18
 Identities = 321/1840 (17%), Positives = 702/1840 (38%), Gaps = 349/1840 (18%)

Query: 20   RQKLLEQSI--QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLT 77
            R+ LL+ S+  Q+  E E ++  +Q+ L ++D+                    ++Q D T
Sbjct: 614  RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEM-------------------QVQLDRT 654

Query: 78   SHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMIL 137
                 L  ++ H +  +   R + +                       FE  L+E+K  +
Sbjct: 655  EWGSDLPSVESHLENHKNVHRAIEE-----------------------FESSLKEAK--I 689

Query: 138  DEVKMHLPALETKSVEQEVVQSQ----LNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 193
             E++M  P   T + +   ++SQ    LN   N  + L  + + V         + +K++
Sbjct: 690  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 749

Query: 194  TENPKELDERVTAL---KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATD 250
             E   +  ER T +   K ++ EL  ++ ++++ ++   +++ ++  E +          
Sbjct: 750  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH---------- 799

Query: 251  MELTKRSAVEGMPSNLDSEVAW----GKATQKEIEKQKVHLKSITEVGEALKTVLGKKET 306
                 R  +E   + + ++ +W     +  ++ I++   + +   +  EA   +   K+ 
Sbjct: 800  ---PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDA 856

Query: 307  LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK 366
             ++ K S   S+ I       +  +L+ E  +  E   Q    I   + +A T++    +
Sbjct: 857  -IQRKYSCDRSSSI------HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII----Q 905

Query: 367  KKPQQKEDVLKR---LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRF 423
             KP+  +  LK    +KA  +  + ++   +D    L  N      K++ P  +E     
Sbjct: 906  LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPS 965

Query: 424  AAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN----LKEEDFNKDMNEDN 479
               +      +A      +EQ   ++  L       ++  V+    + E D    +   N
Sbjct: 966  VCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID---RIRASN 1022

Query: 480  EGTVKELL-----QRGDNLQQRITD--ERKREE--------IKIKQQLLQTKHNALKDLR 524
              ++K +L     Q   NLQ R  D  E  +E          ++++++   K    + L+
Sbjct: 1023 VASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLK 1082

Query: 525  SQRRKKALEISHQWY--QYKRQADDLLKCLDDIEKKLASLPEPRDE--------RKIKEI 574
            S  R++  E  +  Y  + +     L  C D + +++ + P  RD+         + +++
Sbjct: 1083 SAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT-PLERDDLHESVFRITEQEKL 1141

Query: 575  DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIH 634
             +EL++ K++L  +  + E      AA +  PT                           
Sbjct: 1142 KKELERLKDDLGTITNKCEEFFSQAAASSSVPT--------------------------- 1174

Query: 635  TVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLNAPDLCAKDFEDLF 691
             +R E  +V+ ++M  ++  + STY+ ++  V+  L      E L+   +    + E + 
Sbjct: 1175 -LRSELNVVL-QNMN-QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVI 1231

Query: 692  KQEESLKNIKDSLQQSSGRID----IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKV 747
              + +++N+  +L+Q    +D    + H+ +    ++    + +        LDF W K 
Sbjct: 1232 ADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKE 1291

Query: 748  NKMYKDRQGRFDRSVEKWRRFHYDIKI---------------------FNQWLTEAEQFL 786
                     + D+ VE+W+  H  I                        + W+ + E   
Sbjct: 1292 ---------KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1342

Query: 787  RKTQI--PENWEHA-----KYKWYLKEL---QDGIGQRQTVVRTLNATGEEIIQQSSKTD 836
            RK Q   PEN +       + K  + E+   Q  + + Q      +AT ++   Q+    
Sbjct: 1343 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYR 1402

Query: 837  ASILQEKLGSLNLRWQE-----VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 891
            A +  ++   +  R  +     + ++  D + R      +++++ +   + +  LEE   
Sbjct: 1403 AMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEE-- 1460

Query: 892  IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLE 951
                  E   E++ KE +E+ K L + +      LK   + G P      IS EE    +
Sbjct: 1461 ------EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1514

Query: 952  NKLKQTNLQWIKV------SRALPEKQGEIEAQIKDLGQ--------------------- 984
             +L +  LQ I++       +   E++ E+E Q+K L +                     
Sbjct: 1515 EQLSEA-LQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGD 1573

Query: 985  --LEKKL-----EDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPD 1037
              +E+K+     ++ +E+L  +   L+   N+L  + +    G   V+  +   Q+KQ +
Sbjct: 1574 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKY--QSKQEE 1631

Query: 1038 VEEILSKGQHLYKE--KPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIG 1094
            +++ +        E  K     +K   E LS E KA + + L E + K   L        
Sbjct: 1632 LQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSK 1691

Query: 1095 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD----- 1149
                + VT   +    K  A+ +LE  S   +E             L DWLS +D     
Sbjct: 1692 KELDKVVTTAIKEETEKVAAVKQLE-ESKTKIE------------NLLDWLSNVDKDSER 1738

Query: 1150 ------QVIKSQ---------RVMVGDLEDINEMIIKQKA------TMQDLEQR----RP 1184
                  QVI+           +  +G+ +++N  +++         T ++L Q+    + 
Sbjct: 1739 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1798

Query: 1185 QLEELITAAQNLKNKTSN------QEARTIITDRIERIQNQWDEVQEHLQN------RRQ 1232
            Q E++I+  Q +   T +      ++ + +  +  E++Q    E++ H +       ++ 
Sbjct: 1799 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1858

Query: 1233 QLNEMLKDSTQWLEAK-EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQ 1291
            +L   L++  +  +A   E E  L Q+  +LE+ + G   ++ +  K+   K  ++D+  
Sbjct: 1859 KLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 1918

Query: 1292 WQTN---VDVANDLALKLLRDYSADDT---------RKVHMITENINASWRSIHKRVSER 1339
             + +   + ++ +  L+  +  S  D          R+V    ++    +RS++ + +  
Sbjct: 1919 HKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVL 1978

Query: 1340 EAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD 1399
               L++     Q +       LA L   E TA+        E +  D K ++  +++ + 
Sbjct: 1979 GNNLKDLVDKYQHYEDASCGLLAGLQACEATAS----KHLSEPIAVDPKNLQRQLEETKA 2034

Query: 1400 LQGEIEAHTDVYHNLDENSQKILRS----LEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 1455
            LQG+I +       L + ++ +L +    L   +D   +Q+ LD++  ++ +L K     
Sbjct: 2035 LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND---IQKTLDDIVGRYEDLSKSVNER 2091

Query: 1456 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ-------------- 1501
               L+ +  +   +   L E+L W+   +  L  Q  +  +  A+Q              
Sbjct: 2092 NEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIA 2151

Query: 1502 -KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 1560
             +Q+ ++   ++  K  E    ST  +++  + +      E  ++    L   E  +   
Sbjct: 2152 GRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKV 2211

Query: 1561 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 1620
             L    +E++ T  E       +      +  E  Q +QE+T E     +  EV+    +
Sbjct: 2212 ELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLK 2271

Query: 1621 PVGD--------LLIDSLQDHLEKVKALRGEIAPLKENVS 1652
             +          L+++   +  +K K +   I   KE V+
Sbjct: 2272 EISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVT 2311



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 216/1059 (20%), Positives = 424/1059 (40%), Gaps = 156/1059 (14%)

Query: 692  KQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMY 751
            K ++ L+ +KD L   + + +   S+  AA  S+ P  R +L   L  ++ Q   ++  Y
Sbjct: 1140 KLKKELERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMN-QVYSMSSTY 1196

Query: 752  KDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQD 809
             D+    +  ++  +     +K++   L E E  +      EN      +W   + E + 
Sbjct: 1197 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 1256

Query: 810  GIGQRQTVVRTLNATGEEIIQQSSKTDASI--LQEKLGSLNLRWQEVCKQLSDRKKRLEE 867
                 +  ++   A  +E+ +   + D      +EK   L  RWQ V  Q+ +R + LE 
Sbjct: 1257 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 1316

Query: 868  QKNILSEFQRDLNEFVLWLEEADNIASIPLE--PGKEQQLKEKLEQVKLLVEELPLRQGI 925
                L  ++   +    W+++ +       E  P   + L  +L Q K+LV E+ ++Q  
Sbjct: 1317 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1376

Query: 926  LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 985
            + +  +       SA +   E   +  +    + Q   V R     Q   +  I++   L
Sbjct: 1377 MDECQKYAEQY--SATVKDYELQTMTYRAMVDSQQKSPVKRR--RMQSSADLIIQEFMDL 1432

Query: 986  EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKG 1045
              +   L   +   + +      +LE      +E   + ++ E   +AK+  +++ +S  
Sbjct: 1433 RTRYTALVTLMTQYIKFAGDSLKRLE-----EEEKSLEEEKKEHVEKAKE--LQKWVSNI 1485

Query: 1046 QHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL 1103
                K  EK    P  +  + +SSE         E+  K+  L+  L TI          
Sbjct: 1486 SKTLKDAEKAGKPPFSK--QKISSE---------EISTKKEQLSEALQTI---------- 1524

Query: 1104 VTQPVVTKETAISKLEMPSSLMLEVPALAD-FNRAWTELTDWLSLLDQVIKSQRVMVGDL 1162
              Q  + K       E  + L  +V  L + +N  ++E       L Q+ +SQ    GD+
Sbjct: 1525 --QLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES------LKQLQESQTS--GDV 1574

Query: 1163 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE--RIQNQW 1220
            + + E I+ ++   Q+ +++   + +L+T  +N      +QEA  I    +E  + Q++ 
Sbjct: 1575 K-VEEKIVAER--QQEYKEKLQGICDLLTQTEN--RLIGHQEAFMIGDGTVELKKYQSKQ 1629

Query: 1221 DEVQEHLQNRRQQLNEMLKDSTQWL---------EAKEEAEQVLGQARAKLE-------- 1263
            +E+Q+ +Q   Q L E++K++  +L         E K   EQ L +A+ K E        
Sbjct: 1630 EELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQ 1689

Query: 1264 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 1323
            S KE    V    K+ TE     K L + +T ++   D    + +D     T+   +I +
Sbjct: 1690 SKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQ 1749

Query: 1324 NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQ-DATRKER 1382
            N        H +  + ++A+ E                    E E   N+L+ D   +  
Sbjct: 1750 N------GTHFQEGDGKSAIGE--------------------EDEVNGNLLETDVDGQVG 1783

Query: 1383 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1442
              +++     L +Q+Q ++ + E        +    Q ++ + + +   VLL+++   ++
Sbjct: 1784 TTQEN-----LNQQYQKVKAQHE-------KIISQHQAVIIATQSAQ--VLLEKQGQYLS 1829

Query: 1443 FKWSE-LRKKSLNIRSHLE---ASSDQWKRLHLSLQELLV-----------WLQLKDDEL 1487
             +  E L+K    ++ H E   A S++  +L  SLQE L            WLQ  + EL
Sbjct: 1830 PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL 1889

Query: 1488 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLT-EQPLEGLEKLYQ- 1545
                    D       N +    KR+    E VI    +   I ++  + LE  +   + 
Sbjct: 1890 ENLEAGADDI------NGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKR 1943

Query: 1546 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 1605
            +  ++      + V R L    +   + + K N+        + + +++ Q  ++A+  L
Sbjct: 1944 DGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLG----NNLKDLVDKYQHYEDASCGL 1999

Query: 1606 --DLKLRQAEVIKGSWQPVGDLLID--SLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 1661
               L+  +A   K   +P+    +D  +LQ  LE+ KAL+G+I+  +  V  +   A  L
Sbjct: 2000 LAGLQACEATASKHLSEPIA---VDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVL 2056

Query: 1662 TTLGIQLSPYN---LSTLEDLNTRWKLLQVAVEDRVRQL 1697
                  L P       TL+D+  R++ L  +V +R  +L
Sbjct: 2057 LDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL 2095


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score =  248 bits (632), Expect = 7e-65
 Identities = 348/1764 (19%), Positives = 734/1764 (41%), Gaps = 167/1764 (9%)

Query: 15   LNAVRRQ--KLLEQSIQSAQETEKSLHLIQESLTFIDK-QLAAYIADKVDAAQMP--QEA 69
            L A+ +Q  KLL+++    ++ E ++  ++E  + + +  +    A++ + +Q P   E 
Sbjct: 3209 LEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMET 3268

Query: 70   QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR 118
            + I   L   ++  +E  +  QGK+     L Q  I  A K          L DV+ +++
Sbjct: 3269 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWK 3328

Query: 119  -LFQKPANFEQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNH 163
             L +K A    +LQE+ +     +  L +L              +  S E +VV++Q+  
Sbjct: 3329 TLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQE 3388

Query: 164  CVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQ 223
               L + L + KS VE++ + G +I    +  +  ++ ++++ L   +  L  K   R +
Sbjct: 3389 QKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNR 3448

Query: 224  QLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQ 283
            QLE    ++++  + +  L EWL   +  L     +    S L+ ++A  KA + +I   
Sbjct: 3449 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3508

Query: 284  KVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 342
              HL     +G++LK +  +++  +V+ KL      +I +  ++     LL +   + + 
Sbjct: 3509 NKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKI 3568

Query: 343  FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 402
            F ++   +  W+ +    L  S+        + L + ++EL  ++  +   +      + 
Sbjct: 3569 FGEDEVELMNWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALL 3626

Query: 403  NRGDHCRKLVEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL-------- 452
            N  +  ++    ++  +  +  AI  R K  T  ++   K LEQ     ++L        
Sbjct: 3627 NGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3686

Query: 453  --LEPLEAEI--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDE 500
              L+ +E E+   +   LK E+ +      K++ ++  N   + + L    +    +   
Sbjct: 3687 TWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPW 3746

Query: 501  RKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLA 560
            R RE ++        ++  + D  +Q+ ++      +  Q+ + AD  L  + + EKKL 
Sbjct: 3747 RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLM 3806

Query: 561  SLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIES 620
            SL + R E+   +   +LQ +K     + R  + +  D    +        S+  ++   
Sbjct: 3807 SLGDIRLEQD--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMK 3862

Query: 621  KFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAP 680
            K       N+  I  +  E  + +     L ++    TY      +   L E + +++  
Sbjct: 3863 KKLDKVLKNYDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQL 3917

Query: 681  DLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQL 740
               A ++E L +Q+E  + +++ + +    ID ++ K    L   +P E   +QE     
Sbjct: 3918 PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAA 3976

Query: 741  DFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHA 798
            D  + ++ +  K R    D ++ +  +FH  I   +Q L   E+ + + + P +   E  
Sbjct: 3977 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVE 4033

Query: 799  KYKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRW 851
            K K  + E ++    + + Q +  TL   GEE+I +S  TD  I    +Q+KL  +   W
Sbjct: 4034 KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIW 4093

Query: 852  QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLE 910
            + +   + +R+ +L +   +  +F  D    ++ +++  +      +PG +  + K++ E
Sbjct: 4094 ENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQE 4153

Query: 911  QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRAL 968
              + + EE+   Q  L  +   G  ++ +      E DK  ++  + + N  W  +++A 
Sbjct: 4154 AAETIREEIDGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAW 4209

Query: 969  PEKQGEIEAQIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQ 1025
             ++  ++E  ++   Q +  L+   D  +     L  +SPI   LE   Q  +E    ++
Sbjct: 4210 KDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LK 4265

Query: 1026 ETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD 1085
            + +     +Q ++E +  + + L K K   +  K  ++D   E K +   L+E       
Sbjct: 4266 QFKSEAYQQQIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER------ 4318

Query: 1086 LAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWL 1145
                                  ++ ++    KLE   +L+    AL  F  A  EL  WL
Sbjct: 4319 ----------------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWL 4347

Query: 1146 SLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEA 1205
            +  + ++  Q+ + GD + I   + K      D+   +  +E +  A  +L   ++ +EA
Sbjct: 4348 THTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEA 4407

Query: 1206 RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESW 1265
              +  +++E +  +W  V E  + R+QQL+  L+ +  +    E+ +Q L      L + 
Sbjct: 4408 SNL-QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLAS 4466

Query: 1266 KEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENI 1325
            K      +  ++++    ++       +           ++L          +     N+
Sbjct: 4467 KPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNL 4526

Query: 1326 NASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLE 1385
               W S+  +++ER+  LEE   L  +F   L+ F+ WLT+AE T NV   A+R   +L+
Sbjct: 4527 KEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILD 4583

Query: 1386 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 1445
                V   + + +    E+ +H +    LD+     L+      D VL++  L ++  +W
Sbjct: 4584 T---VLFQIDEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRW 4639

Query: 1446 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 1505
             ++ ++ +     L+ +  + K+ H +  +L+ WL+  +  L  +  I  D   ++ Q  
Sbjct: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4699

Query: 1506 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 1565
             H+ F++ L  K  V  +T  T                    R L  +    +    L  
Sbjct: 4700 QHKEFQKSLGAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDD 4740

Query: 1566 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GD 1624
               E+  +W+ +   S + Q K++E L    +  +A   L   L + E      QPV GD
Sbjct: 4741 MLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD 4800

Query: 1625 LLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWK 1684
              ID + + ++  KA + E+     +V  +   AR+L       S +    +++L+TRW+
Sbjct: 4801 --IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWE 4858

Query: 1685 LL-------QVAVEDRVRQLHEAH 1701
             +       Q  +E  +RQ  E H
Sbjct: 4859 TVCALSISKQTRLEAALRQAEEFH 4882



 Score =  216 bits (549), Expect = 3e-55
 Identities = 302/1617 (18%), Positives = 647/1617 (40%), Gaps = 189/1617 (11%)

Query: 97   QRVLSQIDVAQKKLQDVSMKFRLFQK---PAN-----FEQRLQESKMILDEV-KMHLPAL 147
            + +L++ +   ++L+ +S+  + F +   P N      E+RL   + I  +  K+     
Sbjct: 3437 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3496

Query: 148  ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTAL 207
            + K++E +++    NH  +L++++S  +S   +  +  + +VQ K           +   
Sbjct: 3497 QHKALEDDII----NHNKHLHQAVSIGQSLKVLSSREDKDMVQSK-----------LDFS 3541

Query: 208  KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 267
            ++ Y E+  K   R + L++ L  ++   ++   L  WL     +L+K S  +     L 
Sbjct: 3542 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3601

Query: 268  SEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 326
             + +  +  Q++I  +K ++      G E LK   G +  +++DKL  + + +  +T  +
Sbjct: 3602 KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3661

Query: 327  EEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDVL---KRLKA 381
             +    L +  +         + +  W+  ++ + L  E++  K ++        K LK 
Sbjct: 3662 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3721

Query: 382  ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI--KTGKASIPL 439
            E  + +  +DS  + ++ L+       R+ +E  ++E N R+  +S  I  K  +    +
Sbjct: 3722 EAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3781

Query: 440  KELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED---NEGTVKE 485
               +QF+              +KL+   +  ++Q     +    K    +   ++  + +
Sbjct: 3782 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDD 3841

Query: 486  LLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQA 545
            L++ G  +    ++E K + +K K   +   ++ +  + S+R  +         Q+    
Sbjct: 3842 LVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETY 3900

Query: 546  DDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEELNAVRRQAEG 594
            ++L   L + +  ++ LP P            + R+++E+  E +   +++N    Q   
Sbjct: 3901 EELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 3960

Query: 595  LSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISY 654
            LS  G   +++   +     + +I+      ++   A    + + T      D  LE   
Sbjct: 3961 LSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDKIDQILESLE 4016

Query: 655  VPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDII 714
                 L +   +S  + ++++ ++     + D E L    E+LK   + +   SG  D  
Sbjct: 4017 RIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4076

Query: 715  HSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI 774
             S K              +Q+ L Q+ F WE ++ + ++R+ +    +E   +F  D   
Sbjct: 4077 ISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMS 4123

Query: 775  FNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGE 826
                + + + F+R  + P        +  E A+    ++E  DG+ +   +V  L   G 
Sbjct: 4124 LIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDIVINL---GS 4177

Query: 827  EIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWL 886
            E+I    + D  I+++ +  LN  W  + K   DR  +LEE      ++Q  L     W+
Sbjct: 4178 ELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWV 4237

Query: 887  EEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPE 945
            + A   +AS+       + +K+++E++K    E   +Q  +++LN     +L       E
Sbjct: 4238 DIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT---E 4294

Query: 946  EQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 1003
            E DK  +++ L +  L W  +   +  +Q ++E  +  LGQ +  L++L       L WL
Sbjct: 4295 ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-------LAWL 4347

Query: 1004 SPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQHLYKEKPAT 1055
            +     L    Q    G     E E+A        V A Q  VE +   G  L +     
Sbjct: 4348 THTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGE 4405

Query: 1056 QP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKET 1113
            +   ++ KLE L+  W+ V                                      ++T
Sbjct: 4406 EASNLQNKLEVLNQRWQNV-------------------------------------LEKT 4428

Query: 1114 AISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK 1173
               K ++  +L         F+    +L  WL+  ++ + + + + G  E   E +    
Sbjct: 4429 EQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM 4484

Query: 1174 ATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 1233
                  E +    + L+   Q +  +   + A T I   I  ++ +W+ V+  L  R+ +
Sbjct: 4485 EVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVETKLNERKTK 4543

Query: 1234 LNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 1293
            L E L  + ++  + ++    L QA   L         +D +  +I E K  A ++   +
Sbjct: 4544 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHR 4603

Query: 1294 TNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQF 1353
              +   +     L       D   +  +  ++ + W  + +R+ ER  +L++  +  +QF
Sbjct: 4604 EQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQF 4663

Query: 1354 PLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHN 1413
                 K + WL E+E + +       +  +  D   +K  + Q ++ Q  + A   VY  
Sbjct: 4664 HEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDT 4717

Query: 1414 LDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSL 1473
             +   + +      +DD + L   L  +  KW  +  KS+  ++ LE +     +   +L
Sbjct: 4718 TNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4777

Query: 1474 QELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLT 1533
            Q L+ WL   + +L+   P+ GD   V    D H+AF++EL  +                
Sbjct: 4778 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT--------------- 4822

Query: 1534 EQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLE 1593
                  ++ L +  REL   E +++ +  ++ Q +E++T WE +   S   Q +++  L 
Sbjct: 4823 ----SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALR 4876

Query: 1594 RLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVKALRGEI 1644
            + +E       L   L +AE        + D       LID  ++ ++K++  R E+
Sbjct: 4877 QAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAEL 4933



 Score =  212 bits (540), Expect = 3e-54
 Identities = 302/1584 (19%), Positives = 628/1584 (39%), Gaps = 175/1584 (11%)

Query: 102  QIDVAQKKLQDVSMKFRLFQKPAN-----FEQRLQESKMI----------LDEVKMHLPA 146
            ++ + Q KL+ +  +++   K +       EQ LQ ++ +          LD+V++ L +
Sbjct: 3639 EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLS 3698

Query: 147  LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTA 206
             ET+ ++ E           L K     K+ ++ + +    +++       + L++ V  
Sbjct: 3699 YETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE 3758

Query: 207  LKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNL 266
                Y  +   +T++ ++++  +  S++  +  +    W+  T+ +L     +       
Sbjct: 3759 DNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT 3818

Query: 267  DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSR 325
             +++   K    EI + K  +  + + G  + T   ++E   ++ KL  +  N+  +   
Sbjct: 3819 SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQI 3878

Query: 326  AEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD-------ESEKKKPQQKED-VLK 377
              E    L   Q  +  F +  + +  W+ +  +++        E E  + QQ+E   L+
Sbjct: 3879 NSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLR 3938

Query: 378  RLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASI 437
             L AE      K++ T  Q   L    G      ++ +    +  ++ I   +K    ++
Sbjct: 3939 ELIAEHKPHIDKMNKTGPQLLELSPGEGFS----IQEKYVAADTLYSQIKEDVKKRAVAL 3994

Query: 438  P--LKELEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTV------- 483
               + +  QF+  I ++LE LE  +++      ++ + E   + ++E+   +V       
Sbjct: 3995 DEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQP 4054

Query: 484  --KELLQRGDNLQQRITDERKREEIKIKQQLLQTK---HNALKDLRSQRRKKALEISHQW 538
              + L QRG+ +  R     K    K  Q  L         +  L  +R  K L++    
Sbjct: 4055 LYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4114

Query: 539  YQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKKEELNAVRRQAE---G 594
             ++      L+  + D +  +  L +P  D   +K+     +  +EE++ ++ + +    
Sbjct: 4115 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVIN 4174

Query: 595  LSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISY 654
            L  +  A   EP +  + K   E+ S +    +    +I  + EE M    +        
Sbjct: 4175 LGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL-EEAMQAAVQ-------- 4225

Query: 655  VPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDII 714
                Y   +  V   +      L +      D E + +Q E LK  K    Q    ++ +
Sbjct: 4226 ----YQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERL 4281

Query: 715  HSKKTAALQSATPV-ERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 773
            + +    L+  T   ++  +Q+ L +L   W+ + +   +RQ + + ++    +F + + 
Sbjct: 4282 NHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4341

Query: 774  IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQ 830
                WLT  E  L + Q P   +    +  L +   LQ+ +   Q+ V  +N  G ++I+
Sbjct: 4342 ELLAWLTHTEGLLSE-QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIE 4400

Query: 831  QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 890
             S+  +AS LQ KL  LN RWQ V ++   RK++L+        F  ++ +   WL + +
Sbjct: 4401 SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTE 4460

Query: 891  N--IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQ- 947
               +AS PL  G  +  KE+L     +      ++   K L + G  +L   P S E   
Sbjct: 4461 RHLLASKPLG-GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4519

Query: 948  DKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIR 1007
            D+  N LK+   +W  V   L E++ ++E  +    +    L+D        + WL+   
Sbjct: 4520 DQDINNLKE---KWESVETKLNERKTKLEEALNLAMEFHNSLQDF-------INWLTQAE 4569

Query: 1008 NQLEIYNQPN---QEGPFDVQETEI---AVQAKQPDVEEILSKGQHL--YKEKPATQPVK 1059
              L + ++P+       F + E ++    V + +  + E+   G HL  + +K     +K
Sbjct: 4570 QTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK 4629

Query: 1060 RKLEDLSSEW-KAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKL 1118
              L  + S W K V RL++  R                                      
Sbjct: 4630 NLLISVQSRWEKVVQRLVERGR-------------------------------------- 4651

Query: 1119 EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD 1178
                SL         F+ AW++L +WL   ++ + S+  +  D + I   + + K   + 
Sbjct: 4652 ----SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKS 4707

Query: 1179 LEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEML 1238
            L  +    +      ++LK KTS  +    + D +  ++++WD +      R+ +L E L
Sbjct: 4708 LGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEAL 4767

Query: 1239 KDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDV 1298
              S Q+ +A +     L +   +L   +     +D +   I   K   K+L +  ++V  
Sbjct: 4768 LFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQA 4827

Query: 1299 ANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLE 1358
                A +L+   S DD+  V +  + ++  W ++      ++  LE   R  ++F   + 
Sbjct: 4828 LKRSARELIEG-SRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVH 4886

Query: 1359 KFLAWLTEAETTAN---VLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLD 1415
              L WL EAE T     VL D     R L D    KE MK+ ++ + E+   T +   + 
Sbjct: 4887 ALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQH--KEFMKKLEEKRAELNKATTMGDTV- 4943

Query: 1416 ENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE 1475
                    ++   D    ++  +  +  ++ E+   +   +  L ++          L+ 
Sbjct: 4944 -------LAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEA 4996

Query: 1476 LLVWLQLKDDELSRQAP--IGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVR---- 1529
            LL WLQ  +  L+ +    I  +   V+     H+ F  E+  K+P +    +T +    
Sbjct: 4997 LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAA 5056

Query: 1530 --------IFLTEQPLEGLEK-----LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 1576
                    I + ++   G ++     LY    +   E +   V  L+ K        W++
Sbjct: 5057 DPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSK--------WQQ 5108

Query: 1577 LNLHSADWQRKIDETLERLQELQE 1600
            + L + + +RK+++ L+RL+EL+E
Sbjct: 5109 VWLLALERRRKLNDALDRLEELRE 5132



 Score =  206 bits (525), Expect = 2e-52
 Identities = 321/1772 (18%), Positives = 710/1772 (40%), Gaps = 195/1772 (11%)

Query: 22   KLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEI 81
            K L Q +    E   S     E++T   K+      +     Q  +E   I   L S   
Sbjct: 2991 KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAY 3050

Query: 82   SLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF--------------RLFQKPANFE 127
            S + +      +++ Q +  Q+D+A++  QD+ ++                + Q+ +   
Sbjct: 3051 SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS 3110

Query: 128  QRLQESKMILD---------------------EVKMHLPALETKSVEQEVVQSQLNHCVN 166
            Q++ E    L+                     E    L ++     + E +Q Q      
Sbjct: 3111 QQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKA 3170

Query: 167  LYKSLSEVKSEVEMVIKTGRQIVQKKQTE-NPKELDERVTALKLHYNELGAKVTERKQQL 225
              K L  + +  +   KT + ++  ++T  +   +   + AL    N+L  +   R++Q+
Sbjct: 3171 FLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3230

Query: 226  EKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQK-EIEKQK 284
            E  +K   +   ++   +  L   +     +  V      ++ ++   K  QK EIE  +
Sbjct: 3231 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3290

Query: 285  VHLKSITEVGEALKTVLGKKETL--VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 342
               + +  +G+ L     K  +   +E  L  +N+ W  +  +  +    L E   H   
Sbjct: 3291 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3350

Query: 343  FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 402
            F   ++ +  W++  + L+  + +K P  +  V+K    E   ++  +D  R     ++ 
Sbjct: 3351 FQDALESLLSWMVDTEELV--ANQKPPSAEFKVVKAQIQEQKLLQRLLDD-RKSTVEVIK 3407

Query: 403  NRGDHCRKLVEP--------QISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 454
              G+      EP        Q+S L+ R+ A+ ++ +T       ++LE  +   Q+  E
Sbjct: 3408 REGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN-----RQLEGISVVAQQFHE 3462

Query: 455  PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK--REEIKIKQQL 512
             LE   +    +++   N +        ++E + +   L+  I +  K   + + I Q L
Sbjct: 3463 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL 3522

Query: 513  LQTKHNALKDLRSQRRKKALEISHQWY-QYKRQADDLLKCLDDIEKKLASLPEPRDERKI 571
                    KD+   +    L+ S  WY + + ++    + L           E  DE ++
Sbjct: 3523 KVLSSREDKDMVQSK----LDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGE--DEVEL 3576

Query: 572  KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 631
                 E+  K  +L+      EGL +  + + V    I L K  + ++        LN  
Sbjct: 3577 MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK--QNVDQAL-----LNGL 3629

Query: 632  QI--HTVREETMMVMTEDMPLEISYVPSTYL-TEITHVSQALLEVEQLLNA--PDLCA-- 684
            ++   T  +E +++  +   ++  Y   T L T++    +  L++ + L++   +LC   
Sbjct: 3630 ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWL 3689

Query: 685  -------KDFE-DLFKQEESL------KNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 730
                     +E  + K EE+       K +K   + +   +D ++   +A L+      R
Sbjct: 3690 DKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAR 3749

Query: 731  VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK-- 788
              L++ +++ + ++  V+     +    D ++ + ++F         W+TE E+ L    
Sbjct: 3750 EGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLG 3809

Query: 789  -TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSL 847
              ++ ++   A+ +   K     I + + ++  L  +G +I+   S+ +   +++KL  +
Sbjct: 3810 DIRLEQDQTSAQLQ-VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKV 3868

Query: 848  NLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIAS-IPLEPGKEQQLK 906
               +  +C+  S+R  +LE  ++++++F     E   WL E  +I S +P    + + L+
Sbjct: 3869 LKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLR 3928

Query: 907  EKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSR 966
            ++ E+ + L E +   +  + ++N+TG  +L    +SP E   ++ K    +  + ++  
Sbjct: 3929 QQQEEHRQLRELIAEHKPHIDKMNKTGPQLL---ELSPGEGFSIQEKYVAADTLYSQIKE 3985

Query: 967  ALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL-SPIRNQLEIYNQPNQEGPFDVQ 1025
             + ++   ++  I    Q   K++ + E L  ++  L  P     E+  +  +E   + +
Sbjct: 3986 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEV--EKIKEQISENK 4043

Query: 1026 ETEIAVQAKQPDVEEILSKGQHLYKEKPAT------QPVKRKLEDLSSEWKAVNRLLQEL 1079
               + ++  QP  E +  +G+ +      T      + V+ KL+ +   W+ ++ L++E 
Sbjct: 4044 NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEER 4103

Query: 1080 RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 1139
             AK                                          +L+V  LA+  + W 
Sbjct: 4104 EAK------------------------------------------LLDVMELAE--KFW- 4118

Query: 1140 ELTDWLSLLDQVIKSQRVMVGDLED--INEMIIK-QKATMQDLEQRRPQLEELITAAQNL 1196
               D +SL+   IK  +  + DLED  I+  ++K Q+   + + +    L+E +    NL
Sbjct: 4119 --CDHMSLI-VTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 4175

Query: 1197 KNK---TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 1253
             ++      +  + I+   I+ + + WD + +  ++R  +L E ++ + Q+ +  +    
Sbjct: 4176 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 4235

Query: 1254 VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 1313
             +  A  KL S       ++ ++++I E KQ   +  Q Q  ++  N  A  LL+  + +
Sbjct: 4236 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4295

Query: 1314 -DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN 1372
             D   V      +   W S+ +R+  R+  LE     L QF   L++ LAWLT  E    
Sbjct: 4296 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL-- 4353

Query: 1373 VLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAV 1432
                 + ++ +  D K ++  + +   LQ ++ AH      +++    ++ S  G ++A 
Sbjct: 4354 ----LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG-EEAS 4408

Query: 1433 LLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP 1492
             LQ +L+ +N +W  + +K+   +  L+ +  Q K  H  +++L  WL   +  L    P
Sbjct: 4409 NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKP 4468

Query: 1493 IGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP 1552
            +GG     ++Q +VH       + KE    S ++  +  L   P      + Q+   L  
Sbjct: 4469 LGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNL-- 4526

Query: 1553 EERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQA 1612
                                +WE +     + + K++E L    E   +  +    L QA
Sbjct: 4527 ------------------KEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQA 4568

Query: 1613 E-VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPY 1671
            E  +  + +P   L++D++   +++ K    E+   +E +  ++     L     +    
Sbjct: 4569 EQTLNVASRP--SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4626

Query: 1672 NL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 1702
             + + L  + +RW+ +   + +R R L +A +
Sbjct: 4627 LIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4658



 Score =  198 bits (503), Expect = 6e-50
 Identities = 343/1820 (18%), Positives = 730/1820 (40%), Gaps = 205/1820 (11%)

Query: 24   LEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE---AQKIQSDLTSHE 80
            ++Q+I  + + +  L  + + L+ +D +L++ +A       M Q+   AQK++ ++   +
Sbjct: 2685 IDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEK 2744

Query: 81   ISL---------------EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN 125
              +               EE  K    ++    + S  DV QK    V            
Sbjct: 2745 KQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2804

Query: 126  FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTG 185
            F+Q  ++ +  LD  K         S + +V++S +    +  K+L+      E  I  G
Sbjct: 2805 FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEG 2864

Query: 186  RQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEW 245
              ++ K Q      L  ++  +K +++    +V ER+ +L++ L+ + K ++++  L  W
Sbjct: 2865 ENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2924

Query: 246  LAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKK 304
            +      L + +  ++  P+  ++ +A  K+ QKE+++    ++ +     +L +V    
Sbjct: 2925 IDKCQNNLEEIKFCLD--PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2982

Query: 305  ETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDES 364
            + +V D+   L      VT +       L    +  + F +      + +  A   LD  
Sbjct: 2983 KEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH 3042

Query: 365  EKKKPQQKED----VLKRLKAELNDIRPKVDSTRDQAANLMANRGD-HCRKLVEPQISEL 419
            +    Q   +    +L+  +  L  ++ +VD  +  A +L+    D      V  Q+  +
Sbjct: 3043 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETI 3102

Query: 420  NHRFAAISHRI--KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNE 477
                + +S ++  K       L+ +  F + I+++         +  ++     + +  +
Sbjct: 3103 AQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQ 3162

Query: 478  DNEGTVKELLQR-------GDNLQQR-----ITDERKREEIKIKQQL--LQTKHNALKDL 523
              + T+K  L++        DN  +       T+E   + + IK+ L  L  + N L D 
Sbjct: 3163 KQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLD- 3221

Query: 524  RSQRRKKALEIS----HQWYQYKRQADDLLKCLDDIEK-------KLASLPEPRDERKI- 571
            R+Q R++ +E +     ++Y   ++   LL+  ++ E+       +  ++ +  +  K+ 
Sbjct: 3222 RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVF 3281

Query: 572  -KEIDRELQKKKEELNAVRRQAEGLSEDGA----AMAVEPTQIQLSKRWREIESKFAQ-F 625
             KE    LQ K++++N +    +GL +  A       +E     ++ RW+ +  K AQ  
Sbjct: 3282 QKEEIEPLQGKQQDVNWL---GQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRA 3338

Query: 626  RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 685
             +L  A +H  R                     +   +  +   +++ E+L+      + 
Sbjct: 3339 AQLQEALLHCGR---------------------FQDALESLLSWMVDTEELVANQKPPSA 3377

Query: 686  DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 745
            +F+ +  Q +  K ++  L      +++I  +      +A P ++VK+ + LS LD +WE
Sbjct: 3378 EFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWE 3437

Query: 746  KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL- 804
             +    + R  + +      ++FH  ++  N+WLT  E+ L   + P   + +K +  + 
Sbjct: 3438 ALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE-PIGTQASKLEEQIA 3496

Query: 805  --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 862
              K L+D I      +    + G+ +   SS+ D  ++Q KL    + + E+ ++   R 
Sbjct: 3497 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3556

Query: 863  KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIPLEPGKEQQLKEKLEQVKLLVEELPL 921
            + L++       F  D  E + WL E  D ++ + ++    + L ++  ++++L E++ L
Sbjct: 3557 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3616

Query: 922  R-----QGILKQL----NETGGPVLV------SAPISPEEQDKLENKLKQTNLQWIKVSR 966
            R     Q +L  L      TG  VL+      +     ++  KL   + +T  Q ++++R
Sbjct: 3617 RKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3676

Query: 967  ALPEKQGEI--------------EAQI-------------KDLGQLEKKLEDLEEQLNHL 999
             L     E+              E Q+             K+L +  K  + L + LN +
Sbjct: 3677 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEV 3736

Query: 1000 ---LLWLSP--IRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPA 1054
               LL L P   R  LE     + E    V +T   +  K  +++  + + Q   +   A
Sbjct: 3737 SSALLELVPWRAREGLEKMVAEDNERYRLVSDT---ITQKVEEIDAAILRSQQFDQAADA 3793

Query: 1055 -------TQPVKRKLEDLSSEWKAVNRLLQELRA------KQPDLAPGL--------TTI 1093
                   T+     L D+  E    +  LQ  +       +  D+   L        T  
Sbjct: 3794 ELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3853

Query: 1094 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW---TELTDWLSLLDQ 1150
                 Q++      V+     I ++     L LE  A +  N+ W    EL  WL+    
Sbjct: 3854 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE-RAQSLVNQFWETYEELWPWLTETQS 3912

Query: 1151 VIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIIT 1210
            +I        + E + +   + +   + + + +P ++++      L   +  +     I 
Sbjct: 3913 IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS--IQ 3970

Query: 1211 DRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP- 1269
            ++       + +++E ++ R   L+E +  STQ+    ++ +Q+L      +E  ++ P 
Sbjct: 3971 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQF---HDKIDQILESLERIVERLRQPPS 4027

Query: 1270 --YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL-RDYSADDTRKVHMITENIN 1326
                V+ I+++I+E K ++ D+ + Q   +       +++ R    D       + + ++
Sbjct: 4028 ISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLD 4087

Query: 1327 AS---WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 1383
                 W +IH  V EREA L +   L ++F  D    +  + + +     L+D      +
Sbjct: 4088 QMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSV 4147

Query: 1384 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 1443
            ++  +   E ++  +++ G ++   D+  NL       L +  G  D  ++++ +D +N 
Sbjct: 4148 VKQQQEAAETIR--EEIDG-LQEELDIVINLGSE----LIAACGEPDKPIVKKSIDELNS 4200

Query: 1444 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 1503
             W  L K   +    LE +     +    LQ +  W+ +   +L+  +PIG D   V++Q
Sbjct: 4201 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4260

Query: 1504 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 1563
             +  + FK E                    +Q +E +E+L  +   L  +   ++    +
Sbjct: 4261 IEELKQFKSE------------------AYQQQIE-MERLNHQAELLLKKVTEESDKHTV 4301

Query: 1564 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 1623
            +    E+   W+ L     + Q K++  L  L + Q A DEL   L   E +    +PVG
Sbjct: 4302 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4361

Query: 1624 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTR 1682
                 +++  L K   L+ ++   +  V  VN     L          NL + LE LN R
Sbjct: 4362 G-DPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4420

Query: 1683 WKLLQVAVEDRVRQLHEAHR 1702
            W+ +    E R +QL  A R
Sbjct: 4421 WQNVLEKTEQRKQQLDGALR 4440



 Score =  191 bits (486), Expect = 6e-48
 Identities = 304/1643 (18%), Positives = 676/1643 (41%), Gaps = 168/1643 (10%)

Query: 36   KSLHLIQESLTFIDKQLAAYIADKVDA---AQMPQEAQKIQSDLTSHEISLEEMKKH-NQ 91
            ++L   +E++    K+L A +A   +A    +M    ++   DL   +  LE + K  N+
Sbjct: 3159 ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK 3218

Query: 92   GKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKS 151
              + AQ    Q++   K+L++             F  +L+E  ++L + + H  +     
Sbjct: 3219 LLDRAQAREEQVEGTIKRLEE-------------FYSKLKEFSILLQKAEEHEESQGPVG 3265

Query: 152  VEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTALKL 209
            +E E +  QLN      K  +  ++ + + V   G+ ++Q   ++ + + L+  +  +  
Sbjct: 3266 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3325

Query: 210  HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 269
             +  L  KV +R  QL++ L    + +  +  L  W+  T+  +  +         + ++
Sbjct: 3326 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQ 3385

Query: 270  VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEE 328
            +   K  Q+ ++ +K  ++ I   GE + T     + + +  +LSLL+S W A+ ++AE 
Sbjct: 3386 IQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAET 3445

Query: 329  WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELNDI 386
                L       + F + ++ + +W+   +  L   E    Q    E+ + + KA  +DI
Sbjct: 3446 RNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDI 3505

Query: 387  RPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 441
                          Q+  ++++R D  + +V+ ++      F+ + + I+  + S    E
Sbjct: 3506 INHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSRSE 3557

Query: 442  LEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRITD 499
            L Q      K+    E E+   +N   +  +K   +D   EG  K+        + R+  
Sbjct: 3558 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRVLQ 3611

Query: 500  ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL 559
            E   + +  KQ + Q   N L+ L+     + L I  +    K +  D+ K   D+ K L
Sbjct: 3612 E---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3668

Query: 560  ASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWRE 617
                +    R++     EL     K E+  +  + + L  + A+ A +    +L K  + 
Sbjct: 3669 EQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEAKN 3725

Query: 618  IESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 673
             ++       ++ A +  V    RE    ++ ED       V  T   ++  +  A+L  
Sbjct: 3726 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAILRS 3784

Query: 674  EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV-- 731
            +Q   A D       +  K+  SL +I+    Q+S ++ +  +     L+    ++ +  
Sbjct: 3785 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3844

Query: 732  ---KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ--------- 777
               K+  A S+ + Q   +K++K+ K+       + E++ +      + NQ         
Sbjct: 3845 SGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELW 3904

Query: 778  -WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK 834
             WLTE +  + +   P  E     + +   ++L++ I + +  +  +N TG ++++ S  
Sbjct: 3905 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3964

Query: 835  TDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADNIA 893
               SI QEK  + +  + ++ + +  R   L+E  +  ++F   +++ +  LE   + + 
Sbjct: 3965 EGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4023

Query: 894  SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDKLE 951
              P    + +++KE++ + K +  ++   Q + + L + G  ++  +  + ++     ++
Sbjct: 4024 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4083

Query: 952  NKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIRNQ 1009
            +KL Q    W  +   + E+    EA++ D+ +L +K        +H  L++ +   ++ 
Sbjct: 4084 DKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQDF 4134

Query: 1010 LEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVKRK 1061
            +     P  +     Q+ E A      +   Q +++ +++ G  L     +P    VK+ 
Sbjct: 4135 IRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS 4194

Query: 1062 LEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMP 1121
            +++L+S W ++N+  ++                                    I KLE  
Sbjct: 4195 IDELNSAWDSLNKAWKD-----------------------------------RIDKLEEA 4219

Query: 1122 SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 1181
                  + A   +      + DW+ +    + S   +  DLE + + I + K    +  Q
Sbjct: 4220 ------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4273

Query: 1182 RRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDS 1241
            ++ ++E L   A+ L  K + +  +  + D +  ++  WD ++E + NR+ +L   L   
Sbjct: 4274 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4333

Query: 1242 TQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVAND 1301
             Q+  A +E    L      L   K       AI+ ++ +   L  D+   Q+ V+  N 
Sbjct: 4334 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4393

Query: 1302 LALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFL 1361
                L+   + ++   +    E +N  W+++ ++  +R+  L+   R  + F  ++E   
Sbjct: 4394 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQ 4453

Query: 1362 AWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKI 1421
             WLT+ E      +     + L    +  KE +    ++    EA  + Y +L +  Q++
Sbjct: 4454 QWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQM 4507

Query: 1422 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 1481
            L     S +   + + ++N+  KW  +  K    ++ LE + +     H SLQ+ + WL 
Sbjct: 4508 LARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4566

Query: 1482 LKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQPLE 1538
              +  L+  +        V  Q D H+ F  E+ +    I+   +T   ++ F  +Q + 
Sbjct: 4567 QAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4626

Query: 1539 GLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQRKI 1588
             ++ L      +  + R + V + L          RK+A++ +  W KL     +W  + 
Sbjct: 4627 LIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLEES 4677

Query: 1589 DETLERLQELQEATDELDLKLRQ 1611
            +++L+   E+    D++  +L Q
Sbjct: 4678 EKSLDSELEIANDPDKIKTQLAQ 4700



 Score =  176 bits (447), Expect = 2e-43
 Identities = 370/1827 (20%), Positives = 735/1827 (40%), Gaps = 273/1827 (14%)

Query: 21   QKLLEQSIQSAQETEKSL-HLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSH 79
            QK ++ S Q+  E  K+  + ++E+   + ++  A I  K++ A++  E   ++++ +  
Sbjct: 1644 QKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKK 1703

Query: 80   EISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDE 139
            E+   +       KE  ++V +   + + K +  ++   L     + E+   + K ++++
Sbjct: 1704 EL---DKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQ 1760

Query: 140  VKMHLPALETKSV---EQEVVQSQLNHCV---------NLYKSLSEVKSEVEMVIKTGRQ 187
               H    + KS    E EV  + L   V         NL +   +VK++ E +I   + 
Sbjct: 1761 NGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQA 1820

Query: 188  IVQKKQT--------------ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS- 232
            ++   Q+              E  ++L + +  LK+HY E     +E+K +L   L+   
Sbjct: 1821 VIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHY-ETALAESEKKMKLTHSLQEEL 1879

Query: 233  RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 292
             K   +      WL  ++ EL    A     + L +++   K+  +++   K  L+ IT 
Sbjct: 1880 EKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITI 1939

Query: 293  VG----EALKTVL----GKKETL-----VEDKLSLLNSNWIAVTSRAEEWLN----LLLE 335
             G    EA K+      GK +T      V+ KL      + ++ S+     N    L+ +
Sbjct: 1940 SGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK 1999

Query: 336  YQKHMETFDQNVDHITKWIIQADTLLDES---EKKKPQQKEDVLKRLKAELNDIRPKVDS 392
            YQ + +     +  +      A   L E    + K  Q++ +  K L+ +++  +  V+ 
Sbjct: 2000 YQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEK 2059

Query: 393  TRDQAANLMANRGD--HCRKLVEPQISELNHRFAAISHRIK------------------- 431
             +  A  L+  RG     +  ++  + ++  R+  +S  +                    
Sbjct: 2060 LKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDG 2119

Query: 432  -------TGKASIPLKELEQF---NSDIQKLLEP---LEAEI---QQGVNLKEEDFNKDM 475
                    G     LKE  Q    ++ +Q ++     LE +I   Q  +N   E   K M
Sbjct: 2120 LDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFM 2179

Query: 476  NEDNEGTVKELLQRGDNLQQRITD-ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEI 534
               +  T   L  +  +L  R ++   K +E   K + L+TK    ++L S++ +  LE 
Sbjct: 2180 ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL-SEKLQTFLET 2238

Query: 535  SHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQ--A 592
              Q           L  +D   K +  L +   E   + +  E +K  E L+++ ++  +
Sbjct: 2239 KTQ----------ALTEVDVPGKDVTELSQYMQESTSEFL--EHKKHLEVLHSLLKEISS 2286

Query: 593  EGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEI 652
             GL  D  A+ +E T   LSK+++E+E               T++E+   V +    L+ 
Sbjct: 2287 HGLPSD-KALVLEKTN-NLSKKFKEMED--------------TIKEKKEAVTSCQEQLDA 2330

Query: 653  SYVPSTYLTE-ITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEE--SLKNIKDSLQQSSG 709
              V    L   I   ++ +  V+    A DL  K  ED  K +E  SLK  +     +SG
Sbjct: 2331 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDL-GKSLEDTKKLQEKWSLKTPEIQKVNNSG 2389

Query: 710  RIDIIH--------SKKTAALQS----------ATPVER-------VKLQEALSQLDFQW 744
             I + +        +K  AA++S          AT  E          +++ ++ +   +
Sbjct: 2390 -ISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2448

Query: 745  EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK---TQIPENWEHAKYK 801
            E +  + KD+    +  + K ++   +     QWL +  +   K   T  P + E  K +
Sbjct: 2449 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2508

Query: 802  -WYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKT-DASILQEKLGSLNLRWQEVCKQLS 859
                K  +  + Q    V+ L     E+++++  T +A   ++ L  ++ +WQE+ +   
Sbjct: 2509 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2568

Query: 860  DRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASI--PLEPGKEQQLKEKLEQVKLLVE 917
            DR+++LEE  N L++FQ    +   WL E + + S+  PL       L  + +QV++L++
Sbjct: 2569 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQ 2627

Query: 918  ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 977
            E   R+   +QL   G  +L      P  +  ++ +L     +W  ++  L ++   I+ 
Sbjct: 2628 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2687

Query: 978  QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPD 1037
             I    Q +  L  L ++L+ L   LS   + L +   P+       Q+ E A + KQ  
Sbjct: 2688 AIVKSTQYQSLLRSLSDKLSDLDNKLS---SSLAVSTHPDAMN----QQLETAQKMKQEI 2740

Query: 1038 VEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGA 1095
             +E   +   Q L ++  A    +    +LS + + + +  +++  K  +    L +  A
Sbjct: 2741 QQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACA 2800

Query: 1096 SPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 1155
            S  Q                                  F +   +   WL    +     
Sbjct: 2801 SSHQ----------------------------------FQQMSRDFQAWLDTKKEEQNKS 2826

Query: 1156 RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIER 1215
              +   L+ +  +I   K   + L  +    E+ I   +NL  KT   E +  +  ++  
Sbjct: 2827 HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSE-KAALQLQLNT 2885

Query: 1216 IQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 1275
            I+  WD   + ++ R  +L E L+ + ++ E  E     + + +  LE  K   + +D  
Sbjct: 2886 IKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIK---FCLDPA 2942

Query: 1276 --QKKITETKQLAKDLRQWQTNVDVANDLALKLL------RDYSADDTR----KVHMITE 1323
              +  I + K L K++ Q    V++ N+ A  LL      ++   D+ +    KV M+TE
Sbjct: 2943 EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE 3002

Query: 1324 NINAS---WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 1380
             +++      ++ ++  E +   +E+ R LQ     L+               + D+   
Sbjct: 3003 QLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD---------------IHDSLGS 3047

Query: 1381 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDN 1440
            +     +K +  L  Q + LQ  ++   D+   L ++        +G+ D +L   +++ 
Sbjct: 3048 QAY--SNKYLTMLQTQQKSLQA-LKHQVDLAKRLAQDLVVEASDSKGTSDVLL---QVET 3101

Query: 1441 MNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAV 1500
            +  + S L ++     S LE           +++E+       DDEL   AP+G D   +
Sbjct: 3102 IAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETL 3161

Query: 1501 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 1560
            QKQ +  +AF ++L+       +  +T ++ L                    EE + ++ 
Sbjct: 3162 QKQKETIKAFLKKLEALMASNDNANKTCKMMLA------------------TEETSPDLV 3203

Query: 1561 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 1620
              +++  E ++ +  KL   +   + +++ T++RL+E      E  + L++AE  + S  
Sbjct: 3204 G-IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQG 3262

Query: 1621 PVGDLLIDSLQDHLEKVKAL-RGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST---- 1675
            PVG +  +++   L   K   + EI PL+     VN L + L    IQ +  + ST    
Sbjct: 3263 PVG-METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL----IQSAAKSTSTQGLE 3317

Query: 1676 --LEDLNTRWKLLQVAVEDRVRQLHEA 1700
              L+D+N RWK L   V  R  QL EA
Sbjct: 3318 HDLDDVNARWKTLNKKVAQRAAQLQEA 3344



 Score =  161 bits (407), Expect = 8e-39
 Identities = 282/1447 (19%), Positives = 579/1447 (40%), Gaps = 202/1447 (13%)

Query: 33   ETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS-HEISLEEMKKHNQ 91
            ETEK L  + +     D+  A     K    ++ +    I   + S H+I     ++  Q
Sbjct: 3800 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ 3859

Query: 92   G-KEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN-FEQRLQESKMILDEVKMHLPALET 149
              K+   +VL   D   +   +  ++    Q   N F +  +E    L E +  +  L  
Sbjct: 3860 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3919

Query: 150  KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 209
             ++E E ++ Q      L + ++E K  ++ + KTG Q+++    E    + E+  A   
Sbjct: 3920 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG-FSIQEKYVAADT 3978

Query: 210  HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 269
             Y+++   V +R   L++ +  S +   +++ + E L      L +  ++      +  +
Sbjct: 3979 LYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 4038

Query: 270  VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-----LVEDKLSLLNSNWIAVTS 324
            ++  K    ++EK +   +++ + GE +    G  +       V+DKL  +   W  + +
Sbjct: 4039 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4098

Query: 325  RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP-------QQKEDVLK 377
              EE    LL+  +  E F    DH++  +   DT     + + P       +Q+++  +
Sbjct: 4099 LVEEREAKLLDVMELAEKFW--CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4156

Query: 378  RLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT--GKA 435
             ++ E++ ++ ++D   +  + L+A  G+  + +V+  I ELN  + +++   K    K 
Sbjct: 4157 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4216

Query: 436  SIPLKELEQFNSDIQKL--------------------LEPLEAEIQQGVNLKEEDFNKDM 475
               ++   Q+   +Q +                    LE ++ +I++    K E + + +
Sbjct: 4217 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4276

Query: 476  NEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEIS 535
                   ++ L  + + L +++T+E  +  ++     L+   ++L++    R+ K     
Sbjct: 4277 E------MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGAL 4330

Query: 536  HQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEID--------RELQKKKEELNA 587
                Q++   D+LL  L   E  L+       + K  EI+         ++   +  + A
Sbjct: 4331 LALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEA 4390

Query: 588  VRRQAEGLSEDGAAMAVEPTQIQL---SKRWREIESKFAQFRR-----LNFAQ-IHTVRE 638
            V +    L E  A       Q +L   ++RW+ +  K  Q ++     L  A+  H   E
Sbjct: 4391 VNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIE 4450

Query: 639  ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 698
            +    +T+     ++  P   L E           EQL    ++CA  FE    +EE+ K
Sbjct: 4451 DLQQWLTDTERHLLASKPLGGLPETAK--------EQLNVHMEVCAA-FE---AKEETYK 4498

Query: 699  NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 758
            ++    QQ   R       K+A            + + ++ L  +WE V     +R+ + 
Sbjct: 4499 SLMQKGQQMLARCP-----KSA---------ETNIDQDINNLKEKWESVETKLNERKTKL 4544

Query: 759  DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPEN------WEHAKYKWYLKELQDGIG 812
            + ++     FH  ++ F  WLT+AEQ L     P        ++  ++K +  E+     
Sbjct: 4545 EEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS--- 4601

Query: 813  QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 872
             R+ ++  L+ TG  +   S K D  +++  L S+  RW++V ++L +R + L++ +   
Sbjct: 4602 HREQIIE-LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRA 4660

Query: 873  SEFQRDLNEFVLWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNE 931
             +F    ++ + WLEE++      LE   +  ++K +L Q K   + L  +  +    N 
Sbjct: 4661 KQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4720

Query: 932  TGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLED 991
            TG  +     ++ ++  KL++ L +   +W  +     E+Q ++E  +   GQ    L+ 
Sbjct: 4721 TGRSLKEKTSLA-DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQA 4779

Query: 992  LEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE 1051
            L +       WL  +  QL   +QP   G  D+    I       D  +   K   L K 
Sbjct: 4780 LID-------WLYRVEPQLA-EDQP-VHGDIDLVMNLI-------DNHKAFQK--ELGKR 4821

Query: 1052 KPATQPVKRKLEDL------SSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 1105
              + Q +KR   +L       S W  V   +QEL  +                +TV  ++
Sbjct: 4822 TSSVQALKRSARELIEGSRDDSSWVKVQ--MQELSTRW---------------ETVCALS 4864

Query: 1106 QPVVTK-ETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 1164
                T+ E A+ + E             +F+     L +WL+  +Q ++   V+  D + 
Sbjct: 4865 ISKQTRLEAALRQAE-------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4911

Query: 1165 INEMIIKQKATMQDLEQRRPQLEELITAAQNL------KNKTSNQEARTIITDRIERIQN 1218
            +  +I + K  M+ LE++R +L +  T    +       + T+ +   TII  R E +  
Sbjct: 4912 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 4971

Query: 1219 QWDEVQEHLQN------RRQQLNEMLKDSTQWLEAK-------------EEAEQVLGQAR 1259
               + Q+ L +       +Q+L E L    QW E               EE + ++ + +
Sbjct: 4972 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 5031

Query: 1260 AKLESWKEGPYTVDAIQKKITET-KQLAKDLRQWQTNVDV-----ANDLALKLLRDYSAD 1313
              +E        VD    K+T+T K+ A D    Q+++ V     A          Y + 
Sbjct: 5032 TFMEEMTRKQPDVD----KVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5087

Query: 1314 DTRKVHMITENIN---ASWRSIHKRVSEREAALEETHRLLQQ------FPLDL--EKFLA 1362
               ++      +N   + W+ +     ER   L +    L++      F  D+  +K++ 
Sbjct: 5088 SQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMR 5147

Query: 1363 WLTEAET 1369
            W+   ++
Sbjct: 5148 WMNHKKS 5154



 Score =  159 bits (401), Expect = 4e-38
 Identities = 321/1720 (18%), Positives = 690/1720 (40%), Gaps = 221/1720 (12%)

Query: 30   SAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKH 89
            S++E       + E+L  I   LA +  DK+   +  +  +++++   S+ +   E  K 
Sbjct: 1517 SSEEISTKKEQLSEALQTIQLFLAKH-GDKMTDEERNELEKQVKTLQESYNLLFSESLKQ 1575

Query: 90   NQGKEAAQRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRL---QESKMILDEVKMHLP 145
             Q  + +  V  +  +  ++ Q+   K + +       E RL   QE+ MI D   + L 
Sbjct: 1576 LQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGT-VELK 1634

Query: 146  ALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVT 205
              ++K   QE +Q  +       ++L+EV    E  +K   +   K   E+   +++++ 
Sbjct: 1635 KYQSK---QEELQKDMQGSA---QALAEVVKNTENFLKENGE---KLSQEDKALIEQKLN 1685

Query: 206  ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 265
              K+   +L  K  + K++L+K +  + K        TE +AA       ++ +E +   
Sbjct: 1686 EAKIKCEQLNLKAEQSKKELDKVVTTAIKEE------TEKVAAVKQLEESKTKIENL--- 1736

Query: 266  LDSEVAWGKATQKEIEKQKV-HLKSITEVGEALKTVLGKKETLVEDKLS--LLNSNWIAV 322
                + W     K+ E+    H + I + G   +   GK     ED+++  LL ++    
Sbjct: 1737 ----LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQ 1792

Query: 323  TSRAEEWLNLLLEYQKHMETFDQNVDHITKWII---QADTLLD-ESEKKKPQQKEDVLKR 378
                +E  NL  +YQK     ++ +      II    A  LL+ + +   P++KE + K 
Sbjct: 1793 VGTTQE--NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN 1850

Query: 379  LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP 438
            +K    +++   ++   ++   M          ++ ++ + +  +    H ++  +    
Sbjct: 1851 MK----ELKVHYETALAESEKKMK-----LTHSLQEELEKFDADYTEFEHWLQQSEQE-- 1899

Query: 439  LKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRIT 498
            L+ LE    DI  L+  L+         +++ F++D+   ++G ++ +   G+ + +   
Sbjct: 1900 LENLEAGADDINGLMTKLK---------RQKSFSEDVIS-HKGDLRYITISGNRVLEAAK 1949

Query: 499  DERKREEIKIK--------QQLLQTKHNALKDLRSQRR---KKALEISHQWYQYKRQADD 547
               KR+  K+         Q+ L    +  + L S+         ++  ++  Y+  +  
Sbjct: 1950 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 2009

Query: 548  LLKCLDDIEKKLAS-LPEP---------RDERKIKEIDRELQKKKEELNAVRRQAEGLSE 597
            LL  L   E   +  L EP         R   + K +  ++  ++  +  +++ AE L +
Sbjct: 2010 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 2069

Query: 598  DGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPS 657
              A  ++ P +  + K   +I  ++    +     ++   E+  + +T  + ++      
Sbjct: 2070 --ARGSLLPAKNDIQKTLDDIVGRYEDLSK----SVNERNEKLQITLTRSLSVQDGL--D 2121

Query: 658  TYLTEITHVSQALLEVEQL-LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 716
              L  + +V  +L E  Q+ LN+  L     +D+  +   L+      Q S   I+ ++ 
Sbjct: 2122 EMLDWMGNVESSLKEQGQVPLNSTAL-----QDIISKNIMLEQDIAGRQSS---INAMNE 2173

Query: 717  KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFN 776
            K    +++  P     LQ  +  L  ++ + +  +K+   + +    K   F    +   
Sbjct: 2174 KVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQ 2233

Query: 777  QWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD 836
             +L    Q L +  +P   +  +   Y++E      + +  +  L++  +EI      +D
Sbjct: 2234 TFLETKTQALTEVDVPGK-DVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSD 2292

Query: 837  ASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIP 896
             +++ EK  +L+ +++E+   + ++K+ +   +  L  FQ  +     W++E      I 
Sbjct: 2293 KALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIV 2352

Query: 897  LEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV--LVSAPISPEEQDKL---- 950
                  + L + LE  K L E+  L+   ++++N +G  +  L+SA  +P +        
Sbjct: 2353 QPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSG 2412

Query: 951  ------ENKLKQTNLQWI-KVSRALPEKQGEIEAQIKDLGQLEK-----------KLEDL 992
                  E     T   W  K   ++ +   +I    +DLG L K           KL+  
Sbjct: 2413 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2472

Query: 993  EEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP----------DVEEIL 1042
            +E+ + ++ WL  +      + Q     P D +  +  V+  +            V+E+ 
Sbjct: 2473 QEESSAMMQWLQKMNKTATKWQQT--PAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELK 2530

Query: 1043 SKGQHLYKEKPATQPV---KRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 1099
             K   L +E P T      K+ L ++ S+W+ +N+L  + + K  + +  LT       Q
Sbjct: 2531 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQ 2590

Query: 1100 TVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMV 1159
                + Q +V KE  +S L                          LS+   ++ +QR  V
Sbjct: 2591 ----LKQWLVEKELMVSVLGP------------------------LSIDPNMLNTQRQQV 2622

Query: 1160 GDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEA-RTIITDRIERIQN 1218
                         +  +Q+   R+PQ E+L  A Q + ++     + R I+ +++  +  
Sbjct: 2623 -------------QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQ 2669

Query: 1219 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 1278
            +WD +   L +R   +++ +  STQ+          L     KL S        DA+ ++
Sbjct: 2670 KWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQ 2729

Query: 1279 ITETKQLAKDLRQWQTNVDVA----NDLALKLLRDY-SADDTRKVHMITENINASWRSIH 1333
            +   +++ ++++Q +  + VA     DL+  +  +Y  A+ +R++  I ++     +   
Sbjct: 2730 LETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAE 2789

Query: 1334 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1393
              V   ++A   +H+  QQ   D   F AWL   +   N     + K  +LE       L
Sbjct: 2790 NHVQHLQSACASSHQ-FQQMSRD---FQAWLDTKKEEQNKSHPISAKLDVLE------SL 2839

Query: 1394 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1453
            +K  +D    + A + +Y       + +L   +GS+ A  LQ +L+ +   W    K+  
Sbjct: 2840 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA-LQLQLNTIKTNWDTFNKQVK 2898

Query: 1454 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR----QAPIGGD-----FPAVQKQN 1504
               + L+ S ++  +    ++ L  W+    + L        P  G+       ++QK+ 
Sbjct: 2899 ERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEM 2958

Query: 1505 DVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERA-QNVTRLL 1563
            D H      L      ++S  E  +  +T++    ++K+     +L  ++   +N+T+  
Sbjct: 2959 DQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 3018

Query: 1564 RKQAEEVNTEWEKLNLHSADWQRKIDETL-------ERLQELQEATDELDLKLRQAEVIK 1616
             K+ +EV+ E  K  L  A  Q  I ++L       + L  LQ     L     Q ++ K
Sbjct: 3019 -KEFQEVSKE-SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAK 3076

Query: 1617 GSWQPVGDLLIDS-----LQDHLEKVKALRGEIAPLKENV 1651
               Q   DL++++       D L +V+ +  E + L + V
Sbjct: 3077 RLAQ---DLVVEASDSKGTSDVLLQVETIAQEHSTLSQQV 3113



 Score =  149 bits (376), Expect = 3e-35
 Identities = 324/1747 (18%), Positives = 698/1747 (39%), Gaps = 230/1747 (13%)

Query: 50   KQLAAYIA-DKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-EAAQRVLSQIDVAQ 107
            K L+  IA D  +  +  +E + +Q  ++S ++++E++KK  +   +A   +L   +  Q
Sbjct: 2023 KHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 2082

Query: 108  KKLQDVSMKFRLFQKPAN-----FEQRLQESKMI---LDEVKMHLPALETKSVEQEVV-- 157
            K L D+  ++    K  N      +  L  S  +   LDE+   +  +E+   EQ  V  
Sbjct: 2083 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2142

Query: 158  -----QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYN 212
                 Q  ++  + L + ++  +S +  + +  ++ ++         L  ++  L   ++
Sbjct: 2143 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFS 2202

Query: 213  ELG-------AKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 265
            E         AK+ E K ++E    LS K++  +   T+  A T++++  +   E +   
Sbjct: 2203 EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ--ALTEVDVPGKDVTE-LSQY 2259

Query: 266  LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSR 325
            +    +     +K +E     LK I+  G      L   + LV +K + L+  +  +   
Sbjct: 2260 MQESTSEFLEHKKHLEVLHSLLKEISSHG------LPSDKALVLEKTNNLSKKFKEMEDT 2313

Query: 326  AEEWLNLLLEYQKHMETFDQNVDHITKW---------IIQ----ADTLLDESEKKKPQQK 372
             +E    +   Q+ ++ F   V  +  W         I+Q    A+ L    E  K  Q+
Sbjct: 2314 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2373

Query: 373  EDVLKRLKAE--------LNDIRPKV-------------------DSTRDQAANLMANRG 405
            +  LK  + +        L ++   V                   + T        AN+G
Sbjct: 2374 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2433

Query: 406  ---------------DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDI 449
                           +    L++ +I+ELN + + +    +   A +  L+++ +  +  
Sbjct: 2434 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2493

Query: 450  QKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIK 509
            Q+   P + E  +    + + F  ++ + N   V+EL  +   L +   D  +    K  
Sbjct: 2494 QQTPAPTDTEAVKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQM 2552

Query: 510  QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDE 568
               + +K   L  L   R++K  E S+   Q++     L + L + E  ++ L P   D 
Sbjct: 2553 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP 2612

Query: 569  RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 628
              +    +++Q   +E    + Q E L+  G  +   P +          +       + 
Sbjct: 2613 NMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGE----------DPSLRGIVKE 2662

Query: 629  NFAQIHTVREETMMVMTEDMP--LEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAK 685
              A + T + +++     D    ++ + V ST Y + +  +S  L +++  L++    + 
Sbjct: 2663 QLAAV-TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST 2721

Query: 686  DFEDLFKQEESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQ 743
              + + +Q E+ + +K  +QQ   +I +  +  +  +AL        VK +   ++L  Q
Sbjct: 2722 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQ 2773

Query: 744  WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 803
             E + K +KD + + +  V+  +        F Q   + + +L   +  +N  H      
Sbjct: 2774 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHP-ISAK 2832

Query: 804  LKELQDGIGQRQTVVRTLNAT----------GEEIIQQSSKTDASILQEKLGSLNLRWQE 853
            L  L+  I   +   +TL A           GE ++ ++  ++ + LQ +L ++   W  
Sbjct: 2833 LDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDT 2892

Query: 854  VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLE 910
              KQ+ +R+ +L+E      +++  +     W+++  +N+  I   L+P + +    KL 
Sbjct: 2893 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKL- 2951

Query: 911  QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPE 970
              K L +E+    G+++ LN T   +L    I  E     ENK                 
Sbjct: 2952 --KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK----------------- 2991

Query: 971  KQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA 1030
                          L +K++ + EQL+     L  +  + + + + ++E      + ++ 
Sbjct: 2992 -------------SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES-----KRQLQ 3033

Query: 1031 VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 1090
               +Q D+ + L    +  K     Q  ++ L+ L  +     RL Q+L  +  D     
Sbjct: 3034 CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD----- 3088

Query: 1091 TTIGASPTQTVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLL 1148
                +  T  V L  + +  + + +S+   E  S L  ++  +  F     E+    +  
Sbjct: 3089 ----SKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEF 3144

Query: 1149 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 1208
            D  + S   +  D E +     KQK T++   ++   LE L+ +  N  NKT      T 
Sbjct: 3145 DDELDSMAPVGRDAETLQ----KQKETIKAFLKK---LEALMASNDNA-NKTCKMMLATE 3196

Query: 1209 ITDR--------IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 1260
             T          +E +  Q +++ +  Q R +Q+   +K   ++    +E   +L +A  
Sbjct: 3197 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 3256

Query: 1261 KLESWKEGPYTVDAIQKKITETKQLAKD-LRQWQTNVDVANDLALKLLRDYS-ADDTRKV 1318
              ES        + I +++   K   K+ +   Q      N L   L++  + +  T+ +
Sbjct: 3257 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3316

Query: 1319 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 1378
                +++NA W++++K+V++R A L+E      +F   LE  L+W+ + E        A 
Sbjct: 3317 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----AN 3371

Query: 1379 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 1438
            +K    E  K VK  +++ + LQ  ++        +    +KI  + E +D   +L ++L
Sbjct: 3372 QKPPSAE-FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQL 3429

Query: 1439 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFP 1498
              ++ +W  L  K+      LE  S   ++ H +L+ L  WL   +  L    PIG    
Sbjct: 3430 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3489

Query: 1499 AVQKQNDVHRAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPE 1553
             +++Q   H+A + ++      +   +S  +++++  + +  + ++    + +   +  +
Sbjct: 3490 KLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3549

Query: 1554 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLK 1608
            E++ + + LL++         E   +   +W  ++ + L +L     +T+ L     +L+
Sbjct: 3550 EKSHSRSELLQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR 3608

Query: 1609 LRQAEVIKGSWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHV 1654
            + Q +++    Q V   L++ L              QD LE +KA   +I  L  +V+  
Sbjct: 3609 VLQEDILLRK-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3667

Query: 1655 NDLARQL 1661
             + A QL
Sbjct: 3668 LEQALQL 3674



 Score = 92.4 bits (228), Expect = 5e-18
 Identities = 321/1840 (17%), Positives = 702/1840 (38%), Gaps = 349/1840 (18%)

Query: 20   RQKLLEQSI--QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLT 77
            R+ LL+ S+  Q+  E E ++  +Q+ L ++D+                    ++Q D T
Sbjct: 625  RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEM-------------------QVQLDRT 665

Query: 78   SHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMIL 137
                 L  ++ H +  +   R + +                       FE  L+E+K  +
Sbjct: 666  EWGSDLPSVESHLENHKNVHRAIEE-----------------------FESSLKEAK--I 700

Query: 138  DEVKMHLPALETKSVEQEVVQSQ----LNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 193
             E++M  P   T + +   ++SQ    LN   N  + L  + + V         + +K++
Sbjct: 701  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760

Query: 194  TENPKELDERVTAL---KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATD 250
             E   +  ER T +   K ++ EL  ++ ++++ ++   +++ ++  E +          
Sbjct: 761  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH---------- 810

Query: 251  MELTKRSAVEGMPSNLDSEVAW----GKATQKEIEKQKVHLKSITEVGEALKTVLGKKET 306
                 R  +E   + + ++ +W     +  ++ I++   + +   +  EA   +   K+ 
Sbjct: 811  ---PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDA 867

Query: 307  LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK 366
             ++ K S   S+ I       +  +L+ E  +  E   Q    I   + +A T++    +
Sbjct: 868  -IQRKYSCDRSSSI------HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII----Q 916

Query: 367  KKPQQKEDVLKR---LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRF 423
             KP+  +  LK    +KA  +  + ++   +D    L  N      K++ P  +E     
Sbjct: 917  LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPS 976

Query: 424  AAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN----LKEEDFNKDMNEDN 479
               +      +A      +EQ   ++  L       ++  V+    + E D    +   N
Sbjct: 977  VCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID---RIRASN 1033

Query: 480  EGTVKELL-----QRGDNLQQRITD--ERKREE--------IKIKQQLLQTKHNALKDLR 524
              ++K +L     Q   NLQ R  D  E  +E          ++++++   K    + L+
Sbjct: 1034 VASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLK 1093

Query: 525  SQRRKKALEISHQWY--QYKRQADDLLKCLDDIEKKLASLPEPRDE--------RKIKEI 574
            S  R++  E  +  Y  + +     L  C D + +++ + P  RD+         + +++
Sbjct: 1094 SAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT-PLERDDLHESVFRITEQEKL 1152

Query: 575  DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIH 634
             +EL++ K++L  +  + E      AA +  PT                           
Sbjct: 1153 KKELERLKDDLGTITNKCEEFFSQAAASSSVPT--------------------------- 1185

Query: 635  TVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLNAPDLCAKDFEDLF 691
             +R E  +V+ ++M  ++  + STY+ ++  V+  L      E L+   +    + E + 
Sbjct: 1186 -LRSELNVVL-QNMN-QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVI 1242

Query: 692  KQEESLKNIKDSLQQSSGRID----IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKV 747
              + +++N+  +L+Q    +D    + H+ +    ++    + +        LDF W K 
Sbjct: 1243 ADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKE 1302

Query: 748  NKMYKDRQGRFDRSVEKWRRFHYDIKI---------------------FNQWLTEAEQFL 786
                     + D+ VE+W+  H  I                        + W+ + E   
Sbjct: 1303 ---------KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1353

Query: 787  RKTQI--PENWEHA-----KYKWYLKEL---QDGIGQRQTVVRTLNATGEEIIQQSSKTD 836
            RK Q   PEN +       + K  + E+   Q  + + Q      +AT ++   Q+    
Sbjct: 1354 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYR 1413

Query: 837  ASILQEKLGSLNLRWQE-----VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 891
            A +  ++   +  R  +     + ++  D + R      +++++ +   + +  LEE   
Sbjct: 1414 AMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEE-- 1471

Query: 892  IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLE 951
                  E   E++ KE +E+ K L + +      LK   + G P      IS EE    +
Sbjct: 1472 ------EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1525

Query: 952  NKLKQTNLQWIKV------SRALPEKQGEIEAQIKDLGQ--------------------- 984
             +L +  LQ I++       +   E++ E+E Q+K L +                     
Sbjct: 1526 EQLSEA-LQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGD 1584

Query: 985  --LEKKL-----EDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPD 1037
              +E+K+     ++ +E+L  +   L+   N+L  + +    G   V+  +   Q+KQ +
Sbjct: 1585 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKY--QSKQEE 1642

Query: 1038 VEEILSKGQHLYKE--KPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIG 1094
            +++ +        E  K     +K   E LS E KA + + L E + K   L        
Sbjct: 1643 LQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSK 1702

Query: 1095 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD----- 1149
                + VT   +    K  A+ +LE  S   +E             L DWLS +D     
Sbjct: 1703 KELDKVVTTAIKEETEKVAAVKQLE-ESKTKIE------------NLLDWLSNVDKDSER 1749

Query: 1150 ------QVIKSQ---------RVMVGDLEDINEMIIKQKA------TMQDLEQR----RP 1184
                  QVI+           +  +G+ +++N  +++         T ++L Q+    + 
Sbjct: 1750 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1809

Query: 1185 QLEELITAAQNLKNKTSN------QEARTIITDRIERIQNQWDEVQEHLQN------RRQ 1232
            Q E++I+  Q +   T +      ++ + +  +  E++Q    E++ H +       ++ 
Sbjct: 1810 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1869

Query: 1233 QLNEMLKDSTQWLEAK-EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQ 1291
            +L   L++  +  +A   E E  L Q+  +LE+ + G   ++ +  K+   K  ++D+  
Sbjct: 1870 KLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 1929

Query: 1292 WQTN---VDVANDLALKLLRDYSADDT---------RKVHMITENINASWRSIHKRVSER 1339
             + +   + ++ +  L+  +  S  D          R+V    ++    +RS++ + +  
Sbjct: 1930 HKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVL 1989

Query: 1340 EAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD 1399
               L++     Q +       LA L   E TA+        E +  D K ++  +++ + 
Sbjct: 1990 GNNLKDLVDKYQHYEDASCGLLAGLQACEATAS----KHLSEPIAVDPKNLQRQLEETKA 2045

Query: 1400 LQGEIEAHTDVYHNLDENSQKILRS----LEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 1455
            LQG+I +       L + ++ +L +    L   +D   +Q+ LD++  ++ +L K     
Sbjct: 2046 LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND---IQKTLDDIVGRYEDLSKSVNER 2102

Query: 1456 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ-------------- 1501
               L+ +  +   +   L E+L W+   +  L  Q  +  +  A+Q              
Sbjct: 2103 NEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIA 2162

Query: 1502 -KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 1560
             +Q+ ++   ++  K  E    ST  +++  + +      E  ++    L   E  +   
Sbjct: 2163 GRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKV 2222

Query: 1561 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 1620
             L    +E++ T  E       +      +  E  Q +QE+T E     +  EV+    +
Sbjct: 2223 ELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLK 2282

Query: 1621 PVGD--------LLIDSLQDHLEKVKALRGEIAPLKENVS 1652
             +          L+++   +  +K K +   I   KE V+
Sbjct: 2283 EISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVT 2322



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 216/1059 (20%), Positives = 424/1059 (40%), Gaps = 156/1059 (14%)

Query: 692  KQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMY 751
            K ++ L+ +KD L   + + +   S+  AA  S+ P  R +L   L  ++ Q   ++  Y
Sbjct: 1151 KLKKELERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMN-QVYSMSSTY 1207

Query: 752  KDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQD 809
             D+    +  ++  +     +K++   L E E  +      EN      +W   + E + 
Sbjct: 1208 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 1267

Query: 810  GIGQRQTVVRTLNATGEEIIQQSSKTDASI--LQEKLGSLNLRWQEVCKQLSDRKKRLEE 867
                 +  ++   A  +E+ +   + D      +EK   L  RWQ V  Q+ +R + LE 
Sbjct: 1268 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 1327

Query: 868  QKNILSEFQRDLNEFVLWLEEADNIASIPLE--PGKEQQLKEKLEQVKLLVEELPLRQGI 925
                L  ++   +    W+++ +       E  P   + L  +L Q K+LV E+ ++Q  
Sbjct: 1328 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1387

Query: 926  LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 985
            + +  +       SA +   E   +  +    + Q   V R     Q   +  I++   L
Sbjct: 1388 MDECQKYAEQY--SATVKDYELQTMTYRAMVDSQQKSPVKRR--RMQSSADLIIQEFMDL 1443

Query: 986  EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKG 1045
              +   L   +   + +      +LE      +E   + ++ E   +AK+  +++ +S  
Sbjct: 1444 RTRYTALVTLMTQYIKFAGDSLKRLE-----EEEKSLEEEKKEHVEKAKE--LQKWVSNI 1496

Query: 1046 QHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL 1103
                K  EK    P  +  + +SSE         E+  K+  L+  L TI          
Sbjct: 1497 SKTLKDAEKAGKPPFSK--QKISSE---------EISTKKEQLSEALQTI---------- 1535

Query: 1104 VTQPVVTKETAISKLEMPSSLMLEVPALAD-FNRAWTELTDWLSLLDQVIKSQRVMVGDL 1162
              Q  + K       E  + L  +V  L + +N  ++E       L Q+ +SQ    GD+
Sbjct: 1536 --QLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES------LKQLQESQTS--GDV 1585

Query: 1163 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE--RIQNQW 1220
            + + E I+ ++   Q+ +++   + +L+T  +N      +QEA  I    +E  + Q++ 
Sbjct: 1586 K-VEEKIVAER--QQEYKEKLQGICDLLTQTEN--RLIGHQEAFMIGDGTVELKKYQSKQ 1640

Query: 1221 DEVQEHLQNRRQQLNEMLKDSTQWL---------EAKEEAEQVLGQARAKLE-------- 1263
            +E+Q+ +Q   Q L E++K++  +L         E K   EQ L +A+ K E        
Sbjct: 1641 EELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQ 1700

Query: 1264 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 1323
            S KE    V    K+ TE     K L + +T ++   D    + +D     T+   +I +
Sbjct: 1701 SKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQ 1760

Query: 1324 NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQ-DATRKER 1382
            N        H +  + ++A+ E                    E E   N+L+ D   +  
Sbjct: 1761 N------GTHFQEGDGKSAIGE--------------------EDEVNGNLLETDVDGQVG 1794

Query: 1383 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1442
              +++     L +Q+Q ++ + E        +    Q ++ + + +   VLL+++   ++
Sbjct: 1795 TTQEN-----LNQQYQKVKAQHE-------KIISQHQAVIIATQSAQ--VLLEKQGQYLS 1840

Query: 1443 FKWSE-LRKKSLNIRSHLE---ASSDQWKRLHLSLQELLV-----------WLQLKDDEL 1487
             +  E L+K    ++ H E   A S++  +L  SLQE L            WLQ  + EL
Sbjct: 1841 PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL 1900

Query: 1488 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLT-EQPLEGLEKLYQ- 1545
                    D       N +    KR+    E VI    +   I ++  + LE  +   + 
Sbjct: 1901 ENLEAGADDI------NGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKR 1954

Query: 1546 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 1605
            +  ++      + V R L    +   + + K N+        + + +++ Q  ++A+  L
Sbjct: 1955 DGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLG----NNLKDLVDKYQHYEDASCGL 2010

Query: 1606 --DLKLRQAEVIKGSWQPVGDLLID--SLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 1661
               L+  +A   K   +P+    +D  +LQ  LE+ KAL+G+I+  +  V  +   A  L
Sbjct: 2011 LAGLQACEATASKHLSEPIA---VDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVL 2067

Query: 1662 TTLGIQLSPYN---LSTLEDLNTRWKLLQVAVEDRVRQL 1697
                  L P       TL+D+  R++ L  +V +R  +L
Sbjct: 2068 LDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL 2106


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score =  248 bits (632), Expect = 7e-65
 Identities = 348/1764 (19%), Positives = 734/1764 (41%), Gaps = 167/1764 (9%)

Query: 15   LNAVRRQ--KLLEQSIQSAQETEKSLHLIQESLTFIDK-QLAAYIADKVDAAQMP--QEA 69
            L A+ +Q  KLL+++    ++ E ++  ++E  + + +  +    A++ + +Q P   E 
Sbjct: 3347 LEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMET 3406

Query: 70   QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR 118
            + I   L   ++  +E  +  QGK+     L Q  I  A K          L DV+ +++
Sbjct: 3407 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWK 3466

Query: 119  -LFQKPANFEQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNH 163
             L +K A    +LQE+ +     +  L +L              +  S E +VV++Q+  
Sbjct: 3467 TLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQE 3526

Query: 164  CVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQ 223
               L + L + KS VE++ + G +I    +  +  ++ ++++ L   +  L  K   R +
Sbjct: 3527 QKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNR 3586

Query: 224  QLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQ 283
            QLE    ++++  + +  L EWL   +  L     +    S L+ ++A  KA + +I   
Sbjct: 3587 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3646

Query: 284  KVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 342
              HL     +G++LK +  +++  +V+ KL      +I +  ++     LL +   + + 
Sbjct: 3647 NKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKI 3706

Query: 343  FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 402
            F ++   +  W+ +    L  S+        + L + ++EL  ++  +   +      + 
Sbjct: 3707 FGEDEVELMNWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALL 3764

Query: 403  NRGDHCRKLVEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL-------- 452
            N  +  ++    ++  +  +  AI  R K  T  ++   K LEQ     ++L        
Sbjct: 3765 NGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3824

Query: 453  --LEPLEAEI--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDE 500
              L+ +E E+   +   LK E+ +      K++ ++  N   + + L    +    +   
Sbjct: 3825 TWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPW 3884

Query: 501  RKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLA 560
            R RE ++        ++  + D  +Q+ ++      +  Q+ + AD  L  + + EKKL 
Sbjct: 3885 RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLM 3944

Query: 561  SLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIES 620
            SL + R E+   +   +LQ +K     + R  + +  D    +        S+  ++   
Sbjct: 3945 SLGDIRLEQD--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMK 4000

Query: 621  KFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAP 680
            K       N+  I  +  E  + +     L ++    TY      +   L E + +++  
Sbjct: 4001 KKLDKVLKNYDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQL 4055

Query: 681  DLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQL 740
               A ++E L +Q+E  + +++ + +    ID ++ K    L   +P E   +QE     
Sbjct: 4056 PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAA 4114

Query: 741  DFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHA 798
            D  + ++ +  K R    D ++ +  +FH  I   +Q L   E+ + + + P +   E  
Sbjct: 4115 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVE 4171

Query: 799  KYKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRW 851
            K K  + E ++    + + Q +  TL   GEE+I +S  TD  I    +Q+KL  +   W
Sbjct: 4172 KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIW 4231

Query: 852  QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLE 910
            + +   + +R+ +L +   +  +F  D    ++ +++  +      +PG +  + K++ E
Sbjct: 4232 ENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQE 4291

Query: 911  QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRAL 968
              + + EE+   Q  L  +   G  ++ +      E DK  ++  + + N  W  +++A 
Sbjct: 4292 AAETIREEIDGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAW 4347

Query: 969  PEKQGEIEAQIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQ 1025
             ++  ++E  ++   Q +  L+   D  +     L  +SPI   LE   Q  +E    ++
Sbjct: 4348 KDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LK 4403

Query: 1026 ETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD 1085
            + +     +Q ++E +  + + L K K   +  K  ++D   E K +   L+E       
Sbjct: 4404 QFKSEAYQQQIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER------ 4456

Query: 1086 LAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWL 1145
                                  ++ ++    KLE   +L+    AL  F  A  EL  WL
Sbjct: 4457 ----------------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWL 4485

Query: 1146 SLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEA 1205
            +  + ++  Q+ + GD + I   + K      D+   +  +E +  A  +L   ++ +EA
Sbjct: 4486 THTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEA 4545

Query: 1206 RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESW 1265
              +  +++E +  +W  V E  + R+QQL+  L+ +  +    E+ +Q L      L + 
Sbjct: 4546 SNL-QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLAS 4604

Query: 1266 KEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENI 1325
            K      +  ++++    ++       +           ++L          +     N+
Sbjct: 4605 KPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNL 4664

Query: 1326 NASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLE 1385
               W S+  +++ER+  LEE   L  +F   L+ F+ WLT+AE T NV   A+R   +L+
Sbjct: 4665 KEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILD 4721

Query: 1386 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 1445
                V   + + +    E+ +H +    LD+     L+      D VL++  L ++  +W
Sbjct: 4722 T---VLFQIDEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRW 4777

Query: 1446 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 1505
             ++ ++ +     L+ +  + K+ H +  +L+ WL+  +  L  +  I  D   ++ Q  
Sbjct: 4778 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4837

Query: 1506 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 1565
             H+ F++ L  K  V  +T  T                    R L  +    +    L  
Sbjct: 4838 QHKEFQKSLGAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDD 4878

Query: 1566 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GD 1624
               E+  +W+ +   S + Q K++E L    +  +A   L   L + E      QPV GD
Sbjct: 4879 MLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD 4938

Query: 1625 LLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWK 1684
              ID + + ++  KA + E+     +V  +   AR+L       S +    +++L+TRW+
Sbjct: 4939 --IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWE 4996

Query: 1685 LL-------QVAVEDRVRQLHEAH 1701
             +       Q  +E  +RQ  E H
Sbjct: 4997 TVCALSISKQTRLEAALRQAEEFH 5020



 Score =  216 bits (549), Expect = 3e-55
 Identities = 302/1617 (18%), Positives = 647/1617 (40%), Gaps = 189/1617 (11%)

Query: 97   QRVLSQIDVAQKKLQDVSMKFRLFQK---PAN-----FEQRLQESKMILDEV-KMHLPAL 147
            + +L++ +   ++L+ +S+  + F +   P N      E+RL   + I  +  K+     
Sbjct: 3575 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3634

Query: 148  ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTAL 207
            + K++E +++    NH  +L++++S  +S   +  +  + +VQ K           +   
Sbjct: 3635 QHKALEDDII----NHNKHLHQAVSIGQSLKVLSSREDKDMVQSK-----------LDFS 3679

Query: 208  KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 267
            ++ Y E+  K   R + L++ L  ++   ++   L  WL     +L+K S  +     L 
Sbjct: 3680 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3739

Query: 268  SEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 326
             + +  +  Q++I  +K ++      G E LK   G +  +++DKL  + + +  +T  +
Sbjct: 3740 KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3799

Query: 327  EEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDVL---KRLKA 381
             +    L +  +         + +  W+  ++ + L  E++  K ++        K LK 
Sbjct: 3800 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3859

Query: 382  ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI--KTGKASIPL 439
            E  + +  +DS  + ++ L+       R+ +E  ++E N R+  +S  I  K  +    +
Sbjct: 3860 EAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3919

Query: 440  KELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED---NEGTVKE 485
               +QF+              +KL+   +  ++Q     +    K    +   ++  + +
Sbjct: 3920 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDD 3979

Query: 486  LLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQA 545
            L++ G  +    ++E K + +K K   +   ++ +  + S+R  +         Q+    
Sbjct: 3980 LVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETY 4038

Query: 546  DDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEELNAVRRQAEG 594
            ++L   L + +  ++ LP P            + R+++E+  E +   +++N    Q   
Sbjct: 4039 EELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 4098

Query: 595  LSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISY 654
            LS  G   +++   +     + +I+      ++   A    + + T      D  LE   
Sbjct: 4099 LSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDKIDQILESLE 4154

Query: 655  VPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDII 714
                 L +   +S  + ++++ ++     + D E L    E+LK   + +   SG  D  
Sbjct: 4155 RIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4214

Query: 715  HSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI 774
             S K              +Q+ L Q+ F WE ++ + ++R+ +    +E   +F  D   
Sbjct: 4215 ISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMS 4261

Query: 775  FNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGE 826
                + + + F+R  + P        +  E A+    ++E  DG+ +   +V  L   G 
Sbjct: 4262 LIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDIVINL---GS 4315

Query: 827  EIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWL 886
            E+I    + D  I+++ +  LN  W  + K   DR  +LEE      ++Q  L     W+
Sbjct: 4316 ELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWV 4375

Query: 887  EEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPE 945
            + A   +AS+       + +K+++E++K    E   +Q  +++LN     +L       E
Sbjct: 4376 DIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT---E 4432

Query: 946  EQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 1003
            E DK  +++ L +  L W  +   +  +Q ++E  +  LGQ +  L++L       L WL
Sbjct: 4433 ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-------LAWL 4485

Query: 1004 SPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQHLYKEKPAT 1055
            +     L    Q    G     E E+A        V A Q  VE +   G  L +     
Sbjct: 4486 THTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGE 4543

Query: 1056 QP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKET 1113
            +   ++ KLE L+  W+ V                                      ++T
Sbjct: 4544 EASNLQNKLEVLNQRWQNV-------------------------------------LEKT 4566

Query: 1114 AISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK 1173
               K ++  +L         F+    +L  WL+  ++ + + + + G  E   E +    
Sbjct: 4567 EQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM 4622

Query: 1174 ATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 1233
                  E +    + L+   Q +  +   + A T I   I  ++ +W+ V+  L  R+ +
Sbjct: 4623 EVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVETKLNERKTK 4681

Query: 1234 LNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 1293
            L E L  + ++  + ++    L QA   L         +D +  +I E K  A ++   +
Sbjct: 4682 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHR 4741

Query: 1294 TNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQF 1353
              +   +     L       D   +  +  ++ + W  + +R+ ER  +L++  +  +QF
Sbjct: 4742 EQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQF 4801

Query: 1354 PLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHN 1413
                 K + WL E+E + +       +  +  D   +K  + Q ++ Q  + A   VY  
Sbjct: 4802 HEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDT 4855

Query: 1414 LDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSL 1473
             +   + +      +DD + L   L  +  KW  +  KS+  ++ LE +     +   +L
Sbjct: 4856 TNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4915

Query: 1474 QELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLT 1533
            Q L+ WL   + +L+   P+ GD   V    D H+AF++EL  +                
Sbjct: 4916 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT--------------- 4960

Query: 1534 EQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLE 1593
                  ++ L +  REL   E +++ +  ++ Q +E++T WE +   S   Q +++  L 
Sbjct: 4961 ----SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALR 5014

Query: 1594 RLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVKALRGEI 1644
            + +E       L   L +AE        + D       LID  ++ ++K++  R E+
Sbjct: 5015 QAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAEL 5071



 Score =  212 bits (540), Expect = 3e-54
 Identities = 302/1584 (19%), Positives = 628/1584 (39%), Gaps = 175/1584 (11%)

Query: 102  QIDVAQKKLQDVSMKFRLFQKPAN-----FEQRLQESKMI----------LDEVKMHLPA 146
            ++ + Q KL+ +  +++   K +       EQ LQ ++ +          LD+V++ L +
Sbjct: 3777 EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLS 3836

Query: 147  LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTA 206
             ET+ ++ E           L K     K+ ++ + +    +++       + L++ V  
Sbjct: 3837 YETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE 3896

Query: 207  LKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNL 266
                Y  +   +T++ ++++  +  S++  +  +    W+  T+ +L     +       
Sbjct: 3897 DNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT 3956

Query: 267  DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSR 325
             +++   K    EI + K  +  + + G  + T   ++E   ++ KL  +  N+  +   
Sbjct: 3957 SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQI 4016

Query: 326  AEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD-------ESEKKKPQQKED-VLK 377
              E    L   Q  +  F +  + +  W+ +  +++        E E  + QQ+E   L+
Sbjct: 4017 NSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLR 4076

Query: 378  RLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASI 437
             L AE      K++ T  Q   L    G      ++ +    +  ++ I   +K    ++
Sbjct: 4077 ELIAEHKPHIDKMNKTGPQLLELSPGEGFS----IQEKYVAADTLYSQIKEDVKKRAVAL 4132

Query: 438  P--LKELEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTV------- 483
               + +  QF+  I ++LE LE  +++      ++ + E   + ++E+   +V       
Sbjct: 4133 DEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQP 4192

Query: 484  --KELLQRGDNLQQRITDERKREEIKIKQQLLQTK---HNALKDLRSQRRKKALEISHQW 538
              + L QRG+ +  R     K    K  Q  L         +  L  +R  K L++    
Sbjct: 4193 LYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4252

Query: 539  YQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKKEELNAVRRQAE---G 594
             ++      L+  + D +  +  L +P  D   +K+     +  +EE++ ++ + +    
Sbjct: 4253 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVIN 4312

Query: 595  LSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISY 654
            L  +  A   EP +  + K   E+ S +    +    +I  + EE M    +        
Sbjct: 4313 LGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL-EEAMQAAVQ-------- 4363

Query: 655  VPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDII 714
                Y   +  V   +      L +      D E + +Q E LK  K    Q    ++ +
Sbjct: 4364 ----YQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERL 4419

Query: 715  HSKKTAALQSATPV-ERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 773
            + +    L+  T   ++  +Q+ L +L   W+ + +   +RQ + + ++    +F + + 
Sbjct: 4420 NHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4479

Query: 774  IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQ 830
                WLT  E  L + Q P   +    +  L +   LQ+ +   Q+ V  +N  G ++I+
Sbjct: 4480 ELLAWLTHTEGLLSE-QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIE 4538

Query: 831  QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 890
             S+  +AS LQ KL  LN RWQ V ++   RK++L+        F  ++ +   WL + +
Sbjct: 4539 SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTE 4598

Query: 891  N--IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQ- 947
               +AS PL  G  +  KE+L     +      ++   K L + G  +L   P S E   
Sbjct: 4599 RHLLASKPLG-GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4657

Query: 948  DKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIR 1007
            D+  N LK+   +W  V   L E++ ++E  +    +    L+D        + WL+   
Sbjct: 4658 DQDINNLKE---KWESVETKLNERKTKLEEALNLAMEFHNSLQDF-------INWLTQAE 4707

Query: 1008 NQLEIYNQPN---QEGPFDVQETEI---AVQAKQPDVEEILSKGQHL--YKEKPATQPVK 1059
              L + ++P+       F + E ++    V + +  + E+   G HL  + +K     +K
Sbjct: 4708 QTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK 4767

Query: 1060 RKLEDLSSEW-KAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKL 1118
              L  + S W K V RL++  R                                      
Sbjct: 4768 NLLISVQSRWEKVVQRLVERGR-------------------------------------- 4789

Query: 1119 EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD 1178
                SL         F+ AW++L +WL   ++ + S+  +  D + I   + + K   + 
Sbjct: 4790 ----SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKS 4845

Query: 1179 LEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEML 1238
            L  +    +      ++LK KTS  +    + D +  ++++WD +      R+ +L E L
Sbjct: 4846 LGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEAL 4905

Query: 1239 KDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDV 1298
              S Q+ +A +     L +   +L   +     +D +   I   K   K+L +  ++V  
Sbjct: 4906 LFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQA 4965

Query: 1299 ANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLE 1358
                A +L+   S DD+  V +  + ++  W ++      ++  LE   R  ++F   + 
Sbjct: 4966 LKRSARELIEG-SRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVH 5024

Query: 1359 KFLAWLTEAETTAN---VLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLD 1415
              L WL EAE T     VL D     R L D    KE MK+ ++ + E+   T +   + 
Sbjct: 5025 ALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQH--KEFMKKLEEKRAELNKATTMGDTV- 5081

Query: 1416 ENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE 1475
                    ++   D    ++  +  +  ++ E+   +   +  L ++          L+ 
Sbjct: 5082 -------LAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEA 5134

Query: 1476 LLVWLQLKDDELSRQAP--IGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVR---- 1529
            LL WLQ  +  L+ +    I  +   V+     H+ F  E+  K+P +    +T +    
Sbjct: 5135 LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAA 5194

Query: 1530 --------IFLTEQPLEGLEK-----LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 1576
                    I + ++   G ++     LY    +   E +   V  L+ K        W++
Sbjct: 5195 DPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSK--------WQQ 5246

Query: 1577 LNLHSADWQRKIDETLERLQELQE 1600
            + L + + +RK+++ L+RL+EL+E
Sbjct: 5247 VWLLALERRRKLNDALDRLEELRE 5270



 Score =  206 bits (525), Expect = 2e-52
 Identities = 321/1772 (18%), Positives = 710/1772 (40%), Gaps = 195/1772 (11%)

Query: 22   KLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEI 81
            K L Q +    E   S     E++T   K+      +     Q  +E   I   L S   
Sbjct: 3129 KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAY 3188

Query: 82   SLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF--------------RLFQKPANFE 127
            S + +      +++ Q +  Q+D+A++  QD+ ++                + Q+ +   
Sbjct: 3189 SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS 3248

Query: 128  QRLQESKMILD---------------------EVKMHLPALETKSVEQEVVQSQLNHCVN 166
            Q++ E    L+                     E    L ++     + E +Q Q      
Sbjct: 3249 QQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKA 3308

Query: 167  LYKSLSEVKSEVEMVIKTGRQIVQKKQTE-NPKELDERVTALKLHYNELGAKVTERKQQL 225
              K L  + +  +   KT + ++  ++T  +   +   + AL    N+L  +   R++Q+
Sbjct: 3309 FLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3368

Query: 226  EKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQK-EIEKQK 284
            E  +K   +   ++   +  L   +     +  V      ++ ++   K  QK EIE  +
Sbjct: 3369 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3428

Query: 285  VHLKSITEVGEALKTVLGKKETL--VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 342
               + +  +G+ L     K  +   +E  L  +N+ W  +  +  +    L E   H   
Sbjct: 3429 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3488

Query: 343  FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 402
            F   ++ +  W++  + L+  + +K P  +  V+K    E   ++  +D  R     ++ 
Sbjct: 3489 FQDALESLLSWMVDTEELV--ANQKPPSAEFKVVKAQIQEQKLLQRLLDD-RKSTVEVIK 3545

Query: 403  NRGDHCRKLVEP--------QISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 454
              G+      EP        Q+S L+ R+ A+ ++ +T       ++LE  +   Q+  E
Sbjct: 3546 REGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN-----RQLEGISVVAQQFHE 3600

Query: 455  PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK--REEIKIKQQL 512
             LE   +    +++   N +        ++E + +   L+  I +  K   + + I Q L
Sbjct: 3601 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL 3660

Query: 513  LQTKHNALKDLRSQRRKKALEISHQWY-QYKRQADDLLKCLDDIEKKLASLPEPRDERKI 571
                    KD+   +    L+ S  WY + + ++    + L           E  DE ++
Sbjct: 3661 KVLSSREDKDMVQSK----LDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGE--DEVEL 3714

Query: 572  KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 631
                 E+  K  +L+      EGL +  + + V    I L K  + ++        LN  
Sbjct: 3715 MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK--QNVDQAL-----LNGL 3767

Query: 632  QI--HTVREETMMVMTEDMPLEISYVPSTYL-TEITHVSQALLEVEQLLNA--PDLCA-- 684
            ++   T  +E +++  +   ++  Y   T L T++    +  L++ + L++   +LC   
Sbjct: 3768 ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWL 3827

Query: 685  -------KDFE-DLFKQEESL------KNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 730
                     +E  + K EE+       K +K   + +   +D ++   +A L+      R
Sbjct: 3828 DKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAR 3887

Query: 731  VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK-- 788
              L++ +++ + ++  V+     +    D ++ + ++F         W+TE E+ L    
Sbjct: 3888 EGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLG 3947

Query: 789  -TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSL 847
              ++ ++   A+ +   K     I + + ++  L  +G +I+   S+ +   +++KL  +
Sbjct: 3948 DIRLEQDQTSAQLQ-VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKV 4006

Query: 848  NLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIAS-IPLEPGKEQQLK 906
               +  +C+  S+R  +LE  ++++++F     E   WL E  +I S +P    + + L+
Sbjct: 4007 LKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLR 4066

Query: 907  EKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSR 966
            ++ E+ + L E +   +  + ++N+TG  +L    +SP E   ++ K    +  + ++  
Sbjct: 4067 QQQEEHRQLRELIAEHKPHIDKMNKTGPQLL---ELSPGEGFSIQEKYVAADTLYSQIKE 4123

Query: 967  ALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL-SPIRNQLEIYNQPNQEGPFDVQ 1025
             + ++   ++  I    Q   K++ + E L  ++  L  P     E+  +  +E   + +
Sbjct: 4124 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEV--EKIKEQISENK 4181

Query: 1026 ETEIAVQAKQPDVEEILSKGQHLYKEKPAT------QPVKRKLEDLSSEWKAVNRLLQEL 1079
               + ++  QP  E +  +G+ +      T      + V+ KL+ +   W+ ++ L++E 
Sbjct: 4182 NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEER 4241

Query: 1080 RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 1139
             AK                                          +L+V  LA+  + W 
Sbjct: 4242 EAK------------------------------------------LLDVMELAE--KFW- 4256

Query: 1140 ELTDWLSLLDQVIKSQRVMVGDLED--INEMIIK-QKATMQDLEQRRPQLEELITAAQNL 1196
               D +SL+   IK  +  + DLED  I+  ++K Q+   + + +    L+E +    NL
Sbjct: 4257 --CDHMSLI-VTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 4313

Query: 1197 KNK---TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 1253
             ++      +  + I+   I+ + + WD + +  ++R  +L E ++ + Q+ +  +    
Sbjct: 4314 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 4373

Query: 1254 VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 1313
             +  A  KL S       ++ ++++I E KQ   +  Q Q  ++  N  A  LL+  + +
Sbjct: 4374 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4433

Query: 1314 -DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN 1372
             D   V      +   W S+ +R+  R+  LE     L QF   L++ LAWLT  E    
Sbjct: 4434 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL-- 4491

Query: 1373 VLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAV 1432
                 + ++ +  D K ++  + +   LQ ++ AH      +++    ++ S  G ++A 
Sbjct: 4492 ----LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG-EEAS 4546

Query: 1433 LLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP 1492
             LQ +L+ +N +W  + +K+   +  L+ +  Q K  H  +++L  WL   +  L    P
Sbjct: 4547 NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKP 4606

Query: 1493 IGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP 1552
            +GG     ++Q +VH       + KE    S ++  +  L   P      + Q+   L  
Sbjct: 4607 LGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNL-- 4664

Query: 1553 EERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQA 1612
                                +WE +     + + K++E L    E   +  +    L QA
Sbjct: 4665 ------------------KEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQA 4706

Query: 1613 E-VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPY 1671
            E  +  + +P   L++D++   +++ K    E+   +E +  ++     L     +    
Sbjct: 4707 EQTLNVASRP--SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4764

Query: 1672 NL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 1702
             + + L  + +RW+ +   + +R R L +A +
Sbjct: 4765 LIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4796



 Score =  198 bits (503), Expect = 6e-50
 Identities = 343/1820 (18%), Positives = 730/1820 (40%), Gaps = 205/1820 (11%)

Query: 24   LEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE---AQKIQSDLTSHE 80
            ++Q+I  + + +  L  + + L+ +D +L++ +A       M Q+   AQK++ ++   +
Sbjct: 2823 IDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEK 2882

Query: 81   ISL---------------EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN 125
              +               EE  K    ++    + S  DV QK    V            
Sbjct: 2883 KQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2942

Query: 126  FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTG 185
            F+Q  ++ +  LD  K         S + +V++S +    +  K+L+      E  I  G
Sbjct: 2943 FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEG 3002

Query: 186  RQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEW 245
              ++ K Q      L  ++  +K +++    +V ER+ +L++ L+ + K ++++  L  W
Sbjct: 3003 ENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 3062

Query: 246  LAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKK 304
            +      L + +  ++  P+  ++ +A  K+ QKE+++    ++ +     +L +V    
Sbjct: 3063 IDKCQNNLEEIKFCLD--PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 3120

Query: 305  ETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDES 364
            + +V D+   L      VT +       L    +  + F +      + +  A   LD  
Sbjct: 3121 KEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH 3180

Query: 365  EKKKPQQKED----VLKRLKAELNDIRPKVDSTRDQAANLMANRGD-HCRKLVEPQISEL 419
            +    Q   +    +L+  +  L  ++ +VD  +  A +L+    D      V  Q+  +
Sbjct: 3181 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETI 3240

Query: 420  NHRFAAISHRI--KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNE 477
                + +S ++  K       L+ +  F + I+++         +  ++     + +  +
Sbjct: 3241 AQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQ 3300

Query: 478  DNEGTVKELLQR-------GDNLQQR-----ITDERKREEIKIKQQL--LQTKHNALKDL 523
              + T+K  L++        DN  +       T+E   + + IK+ L  L  + N L D 
Sbjct: 3301 KQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLD- 3359

Query: 524  RSQRRKKALEIS----HQWYQYKRQADDLLKCLDDIEK-------KLASLPEPRDERKI- 571
            R+Q R++ +E +     ++Y   ++   LL+  ++ E+       +  ++ +  +  K+ 
Sbjct: 3360 RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVF 3419

Query: 572  -KEIDRELQKKKEELNAVRRQAEGLSEDGA----AMAVEPTQIQLSKRWREIESKFAQ-F 625
             KE    LQ K++++N +    +GL +  A       +E     ++ RW+ +  K AQ  
Sbjct: 3420 QKEEIEPLQGKQQDVNWL---GQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRA 3476

Query: 626  RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 685
             +L  A +H  R                     +   +  +   +++ E+L+      + 
Sbjct: 3477 AQLQEALLHCGR---------------------FQDALESLLSWMVDTEELVANQKPPSA 3515

Query: 686  DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 745
            +F+ +  Q +  K ++  L      +++I  +      +A P ++VK+ + LS LD +WE
Sbjct: 3516 EFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWE 3575

Query: 746  KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL- 804
             +    + R  + +      ++FH  ++  N+WLT  E+ L   + P   + +K +  + 
Sbjct: 3576 ALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE-PIGTQASKLEEQIA 3634

Query: 805  --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 862
              K L+D I      +    + G+ +   SS+ D  ++Q KL    + + E+ ++   R 
Sbjct: 3635 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3694

Query: 863  KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIPLEPGKEQQLKEKLEQVKLLVEELPL 921
            + L++       F  D  E + WL E  D ++ + ++    + L ++  ++++L E++ L
Sbjct: 3695 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3754

Query: 922  R-----QGILKQL----NETGGPVLV------SAPISPEEQDKLENKLKQTNLQWIKVSR 966
            R     Q +L  L      TG  VL+      +     ++  KL   + +T  Q ++++R
Sbjct: 3755 RKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3814

Query: 967  ALPEKQGEI--------------EAQI-------------KDLGQLEKKLEDLEEQLNHL 999
             L     E+              E Q+             K+L +  K  + L + LN +
Sbjct: 3815 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEV 3874

Query: 1000 ---LLWLSP--IRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPA 1054
               LL L P   R  LE     + E    V +T   +  K  +++  + + Q   +   A
Sbjct: 3875 SSALLELVPWRAREGLEKMVAEDNERYRLVSDT---ITQKVEEIDAAILRSQQFDQAADA 3931

Query: 1055 -------TQPVKRKLEDLSSEWKAVNRLLQELRA------KQPDLAPGL--------TTI 1093
                   T+     L D+  E    +  LQ  +       +  D+   L        T  
Sbjct: 3932 ELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3991

Query: 1094 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW---TELTDWLSLLDQ 1150
                 Q++      V+     I ++     L LE  A +  N+ W    EL  WL+    
Sbjct: 3992 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE-RAQSLVNQFWETYEELWPWLTETQS 4050

Query: 1151 VIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIIT 1210
            +I        + E + +   + +   + + + +P ++++      L   +  +     I 
Sbjct: 4051 IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS--IQ 4108

Query: 1211 DRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP- 1269
            ++       + +++E ++ R   L+E +  STQ+    ++ +Q+L      +E  ++ P 
Sbjct: 4109 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQF---HDKIDQILESLERIVERLRQPPS 4165

Query: 1270 --YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL-RDYSADDTRKVHMITENIN 1326
                V+ I+++I+E K ++ D+ + Q   +       +++ R    D       + + ++
Sbjct: 4166 ISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLD 4225

Query: 1327 AS---WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 1383
                 W +IH  V EREA L +   L ++F  D    +  + + +     L+D      +
Sbjct: 4226 QMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSV 4285

Query: 1384 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 1443
            ++  +   E ++  +++ G ++   D+  NL       L +  G  D  ++++ +D +N 
Sbjct: 4286 VKQQQEAAETIR--EEIDG-LQEELDIVINLGSE----LIAACGEPDKPIVKKSIDELNS 4338

Query: 1444 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 1503
             W  L K   +    LE +     +    LQ +  W+ +   +L+  +PIG D   V++Q
Sbjct: 4339 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4398

Query: 1504 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 1563
             +  + FK E                    +Q +E +E+L  +   L  +   ++    +
Sbjct: 4399 IEELKQFKSE------------------AYQQQIE-MERLNHQAELLLKKVTEESDKHTV 4439

Query: 1564 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 1623
            +    E+   W+ L     + Q K++  L  L + Q A DEL   L   E +    +PVG
Sbjct: 4440 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4499

Query: 1624 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTR 1682
                 +++  L K   L+ ++   +  V  VN     L          NL + LE LN R
Sbjct: 4500 G-DPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4558

Query: 1683 WKLLQVAVEDRVRQLHEAHR 1702
            W+ +    E R +QL  A R
Sbjct: 4559 WQNVLEKTEQRKQQLDGALR 4578



 Score =  191 bits (486), Expect = 6e-48
 Identities = 304/1643 (18%), Positives = 676/1643 (41%), Gaps = 168/1643 (10%)

Query: 36   KSLHLIQESLTFIDKQLAAYIADKVDA---AQMPQEAQKIQSDLTSHEISLEEMKKH-NQ 91
            ++L   +E++    K+L A +A   +A    +M    ++   DL   +  LE + K  N+
Sbjct: 3297 ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK 3356

Query: 92   GKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKS 151
              + AQ    Q++   K+L++             F  +L+E  ++L + + H  +     
Sbjct: 3357 LLDRAQAREEQVEGTIKRLEE-------------FYSKLKEFSILLQKAEEHEESQGPVG 3403

Query: 152  VEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTALKL 209
            +E E +  QLN      K  +  ++ + + V   G+ ++Q   ++ + + L+  +  +  
Sbjct: 3404 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3463

Query: 210  HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 269
             +  L  KV +R  QL++ L    + +  +  L  W+  T+  +  +         + ++
Sbjct: 3464 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQ 3523

Query: 270  VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEE 328
            +   K  Q+ ++ +K  ++ I   GE + T     + + +  +LSLL+S W A+ ++AE 
Sbjct: 3524 IQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAET 3583

Query: 329  WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELNDI 386
                L       + F + ++ + +W+   +  L   E    Q    E+ + + KA  +DI
Sbjct: 3584 RNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDI 3643

Query: 387  RPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 441
                          Q+  ++++R D  + +V+ ++      F+ + + I+  + S    E
Sbjct: 3644 INHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSRSE 3695

Query: 442  LEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRITD 499
            L Q      K+    E E+   +N   +  +K   +D   EG  K+        + R+  
Sbjct: 3696 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRVLQ 3749

Query: 500  ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL 559
            E   + +  KQ + Q   N L+ L+     + L I  +    K +  D+ K   D+ K L
Sbjct: 3750 E---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3806

Query: 560  ASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWRE 617
                +    R++     EL     K E+  +  + + L  + A+ A +    +L K  + 
Sbjct: 3807 EQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEAKN 3863

Query: 618  IESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 673
             ++       ++ A +  V    RE    ++ ED       V  T   ++  +  A+L  
Sbjct: 3864 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAILRS 3922

Query: 674  EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV-- 731
            +Q   A D       +  K+  SL +I+    Q+S ++ +  +     L+    ++ +  
Sbjct: 3923 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3982

Query: 732  ---KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ--------- 777
               K+  A S+ + Q   +K++K+ K+       + E++ +      + NQ         
Sbjct: 3983 SGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELW 4042

Query: 778  -WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK 834
             WLTE +  + +   P  E     + +   ++L++ I + +  +  +N TG ++++ S  
Sbjct: 4043 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 4102

Query: 835  TDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADNIA 893
               SI QEK  + +  + ++ + +  R   L+E  +  ++F   +++ +  LE   + + 
Sbjct: 4103 EGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4161

Query: 894  SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDKLE 951
              P    + +++KE++ + K +  ++   Q + + L + G  ++  +  + ++     ++
Sbjct: 4162 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4221

Query: 952  NKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIRNQ 1009
            +KL Q    W  +   + E+    EA++ D+ +L +K        +H  L++ +   ++ 
Sbjct: 4222 DKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQDF 4272

Query: 1010 LEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVKRK 1061
            +     P  +     Q+ E A      +   Q +++ +++ G  L     +P    VK+ 
Sbjct: 4273 IRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS 4332

Query: 1062 LEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMP 1121
            +++L+S W ++N+  ++                                    I KLE  
Sbjct: 4333 IDELNSAWDSLNKAWKD-----------------------------------RIDKLEEA 4357

Query: 1122 SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 1181
                  + A   +      + DW+ +    + S   +  DLE + + I + K    +  Q
Sbjct: 4358 ------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4411

Query: 1182 RRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDS 1241
            ++ ++E L   A+ L  K + +  +  + D +  ++  WD ++E + NR+ +L   L   
Sbjct: 4412 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4471

Query: 1242 TQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVAND 1301
             Q+  A +E    L      L   K       AI+ ++ +   L  D+   Q+ V+  N 
Sbjct: 4472 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4531

Query: 1302 LALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFL 1361
                L+   + ++   +    E +N  W+++ ++  +R+  L+   R  + F  ++E   
Sbjct: 4532 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQ 4591

Query: 1362 AWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKI 1421
             WLT+ E      +     + L    +  KE +    ++    EA  + Y +L +  Q++
Sbjct: 4592 QWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQM 4645

Query: 1422 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 1481
            L     S +   + + ++N+  KW  +  K    ++ LE + +     H SLQ+ + WL 
Sbjct: 4646 LARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4704

Query: 1482 LKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQPLE 1538
              +  L+  +        V  Q D H+ F  E+ +    I+   +T   ++ F  +Q + 
Sbjct: 4705 QAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4764

Query: 1539 GLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQRKI 1588
             ++ L      +  + R + V + L          RK+A++ +  W KL     +W  + 
Sbjct: 4765 LIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLEES 4815

Query: 1589 DETLERLQELQEATDELDLKLRQ 1611
            +++L+   E+    D++  +L Q
Sbjct: 4816 EKSLDSELEIANDPDKIKTQLAQ 4838



 Score =  176 bits (447), Expect = 2e-43
 Identities = 370/1827 (20%), Positives = 735/1827 (40%), Gaps = 273/1827 (14%)

Query: 21   QKLLEQSIQSAQETEKSL-HLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSH 79
            QK ++ S Q+  E  K+  + ++E+   + ++  A I  K++ A++  E   ++++ +  
Sbjct: 1782 QKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKK 1841

Query: 80   EISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDE 139
            E+   +       KE  ++V +   + + K +  ++   L     + E+   + K ++++
Sbjct: 1842 EL---DKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQ 1898

Query: 140  VKMHLPALETKSV---EQEVVQSQLNHCV---------NLYKSLSEVKSEVEMVIKTGRQ 187
               H    + KS    E EV  + L   V         NL +   +VK++ E +I   + 
Sbjct: 1899 NGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQA 1958

Query: 188  IVQKKQT--------------ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS- 232
            ++   Q+              E  ++L + +  LK+HY E     +E+K +L   L+   
Sbjct: 1959 VIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHY-ETALAESEKKMKLTHSLQEEL 2017

Query: 233  RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 292
             K   +      WL  ++ EL    A     + L +++   K+  +++   K  L+ IT 
Sbjct: 2018 EKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITI 2077

Query: 293  VG----EALKTVL----GKKETL-----VEDKLSLLNSNWIAVTSRAEEWLN----LLLE 335
             G    EA K+      GK +T      V+ KL      + ++ S+     N    L+ +
Sbjct: 2078 SGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK 2137

Query: 336  YQKHMETFDQNVDHITKWIIQADTLLDES---EKKKPQQKEDVLKRLKAELNDIRPKVDS 392
            YQ + +     +  +      A   L E    + K  Q++ +  K L+ +++  +  V+ 
Sbjct: 2138 YQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEK 2197

Query: 393  TRDQAANLMANRGD--HCRKLVEPQISELNHRFAAISHRIK------------------- 431
             +  A  L+  RG     +  ++  + ++  R+  +S  +                    
Sbjct: 2198 LKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDG 2257

Query: 432  -------TGKASIPLKELEQF---NSDIQKLLEP---LEAEI---QQGVNLKEEDFNKDM 475
                    G     LKE  Q    ++ +Q ++     LE +I   Q  +N   E   K M
Sbjct: 2258 LDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFM 2317

Query: 476  NEDNEGTVKELLQRGDNLQQRITD-ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEI 534
               +  T   L  +  +L  R ++   K +E   K + L+TK    ++L S++ +  LE 
Sbjct: 2318 ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL-SEKLQTFLET 2376

Query: 535  SHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQ--A 592
              Q           L  +D   K +  L +   E   + +  E +K  E L+++ ++  +
Sbjct: 2377 KTQ----------ALTEVDVPGKDVTELSQYMQESTSEFL--EHKKHLEVLHSLLKEISS 2424

Query: 593  EGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEI 652
             GL  D  A+ +E T   LSK+++E+E               T++E+   V +    L+ 
Sbjct: 2425 HGLPSD-KALVLEKTN-NLSKKFKEMED--------------TIKEKKEAVTSCQEQLDA 2468

Query: 653  SYVPSTYLTE-ITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEE--SLKNIKDSLQQSSG 709
              V    L   I   ++ +  V+    A DL  K  ED  K +E  SLK  +     +SG
Sbjct: 2469 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDL-GKSLEDTKKLQEKWSLKTPEIQKVNNSG 2527

Query: 710  RIDIIH--------SKKTAALQS----------ATPVER-------VKLQEALSQLDFQW 744
             I + +        +K  AA++S          AT  E          +++ ++ +   +
Sbjct: 2528 -ISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2586

Query: 745  EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK---TQIPENWEHAKYK 801
            E +  + KD+    +  + K ++   +     QWL +  +   K   T  P + E  K +
Sbjct: 2587 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2646

Query: 802  -WYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKT-DASILQEKLGSLNLRWQEVCKQLS 859
                K  +  + Q    V+ L     E+++++  T +A   ++ L  ++ +WQE+ +   
Sbjct: 2647 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2706

Query: 860  DRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASI--PLEPGKEQQLKEKLEQVKLLVE 917
            DR+++LEE  N L++FQ    +   WL E + + S+  PL       L  + +QV++L++
Sbjct: 2707 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQ 2765

Query: 918  ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 977
            E   R+   +QL   G  +L      P  +  ++ +L     +W  ++  L ++   I+ 
Sbjct: 2766 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2825

Query: 978  QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPD 1037
             I    Q +  L  L ++L+ L   LS   + L +   P+       Q+ E A + KQ  
Sbjct: 2826 AIVKSTQYQSLLRSLSDKLSDLDNKLS---SSLAVSTHPDAMN----QQLETAQKMKQEI 2878

Query: 1038 VEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGA 1095
             +E   +   Q L ++  A    +    +LS + + + +  +++  K  +    L +  A
Sbjct: 2879 QQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACA 2938

Query: 1096 SPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 1155
            S  Q                                  F +   +   WL    +     
Sbjct: 2939 SSHQ----------------------------------FQQMSRDFQAWLDTKKEEQNKS 2964

Query: 1156 RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIER 1215
              +   L+ +  +I   K   + L  +    E+ I   +NL  KT   E +  +  ++  
Sbjct: 2965 HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSE-KAALQLQLNT 3023

Query: 1216 IQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 1275
            I+  WD   + ++ R  +L E L+ + ++ E  E     + + +  LE  K   + +D  
Sbjct: 3024 IKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIK---FCLDPA 3080

Query: 1276 --QKKITETKQLAKDLRQWQTNVDVANDLALKLL------RDYSADDTR----KVHMITE 1323
              +  I + K L K++ Q    V++ N+ A  LL      ++   D+ +    KV M+TE
Sbjct: 3081 EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE 3140

Query: 1324 NINAS---WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 1380
             +++      ++ ++  E +   +E+ R LQ     L+               + D+   
Sbjct: 3141 QLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD---------------IHDSLGS 3185

Query: 1381 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDN 1440
            +     +K +  L  Q + LQ  ++   D+   L ++        +G+ D +L   +++ 
Sbjct: 3186 QAY--SNKYLTMLQTQQKSLQA-LKHQVDLAKRLAQDLVVEASDSKGTSDVLL---QVET 3239

Query: 1441 MNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAV 1500
            +  + S L ++     S LE           +++E+       DDEL   AP+G D   +
Sbjct: 3240 IAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETL 3299

Query: 1501 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 1560
            QKQ +  +AF ++L+       +  +T ++ L                    EE + ++ 
Sbjct: 3300 QKQKETIKAFLKKLEALMASNDNANKTCKMMLA------------------TEETSPDLV 3341

Query: 1561 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 1620
              +++  E ++ +  KL   +   + +++ T++RL+E      E  + L++AE  + S  
Sbjct: 3342 G-IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQG 3400

Query: 1621 PVGDLLIDSLQDHLEKVKAL-RGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST---- 1675
            PVG +  +++   L   K   + EI PL+     VN L + L    IQ +  + ST    
Sbjct: 3401 PVG-METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL----IQSAAKSTSTQGLE 3455

Query: 1676 --LEDLNTRWKLLQVAVEDRVRQLHEA 1700
              L+D+N RWK L   V  R  QL EA
Sbjct: 3456 HDLDDVNARWKTLNKKVAQRAAQLQEA 3482



 Score =  161 bits (407), Expect = 8e-39
 Identities = 282/1447 (19%), Positives = 579/1447 (40%), Gaps = 202/1447 (13%)

Query: 33   ETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS-HEISLEEMKKHNQ 91
            ETEK L  + +     D+  A     K    ++ +    I   + S H+I     ++  Q
Sbjct: 3938 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ 3997

Query: 92   G-KEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN-FEQRLQESKMILDEVKMHLPALET 149
              K+   +VL   D   +   +  ++    Q   N F +  +E    L E +  +  L  
Sbjct: 3998 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 4057

Query: 150  KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 209
             ++E E ++ Q      L + ++E K  ++ + KTG Q+++    E    + E+  A   
Sbjct: 4058 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG-FSIQEKYVAADT 4116

Query: 210  HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 269
             Y+++   V +R   L++ +  S +   +++ + E L      L +  ++      +  +
Sbjct: 4117 LYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 4176

Query: 270  VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-----LVEDKLSLLNSNWIAVTS 324
            ++  K    ++EK +   +++ + GE +    G  +       V+DKL  +   W  + +
Sbjct: 4177 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4236

Query: 325  RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP-------QQKEDVLK 377
              EE    LL+  +  E F    DH++  +   DT     + + P       +Q+++  +
Sbjct: 4237 LVEEREAKLLDVMELAEKFW--CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4294

Query: 378  RLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT--GKA 435
             ++ E++ ++ ++D   +  + L+A  G+  + +V+  I ELN  + +++   K    K 
Sbjct: 4295 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4354

Query: 436  SIPLKELEQFNSDIQKL--------------------LEPLEAEIQQGVNLKEEDFNKDM 475
               ++   Q+   +Q +                    LE ++ +I++    K E + + +
Sbjct: 4355 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4414

Query: 476  NEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEIS 535
                   ++ L  + + L +++T+E  +  ++     L+   ++L++    R+ K     
Sbjct: 4415 E------MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGAL 4468

Query: 536  HQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEID--------RELQKKKEELNA 587
                Q++   D+LL  L   E  L+       + K  EI+         ++   +  + A
Sbjct: 4469 LALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEA 4528

Query: 588  VRRQAEGLSEDGAAMAVEPTQIQL---SKRWREIESKFAQFRR-----LNFAQ-IHTVRE 638
            V +    L E  A       Q +L   ++RW+ +  K  Q ++     L  A+  H   E
Sbjct: 4529 VNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIE 4588

Query: 639  ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 698
            +    +T+     ++  P   L E           EQL    ++CA  FE    +EE+ K
Sbjct: 4589 DLQQWLTDTERHLLASKPLGGLPETAK--------EQLNVHMEVCAA-FE---AKEETYK 4636

Query: 699  NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 758
            ++    QQ   R       K+A            + + ++ L  +WE V     +R+ + 
Sbjct: 4637 SLMQKGQQMLARCP-----KSA---------ETNIDQDINNLKEKWESVETKLNERKTKL 4682

Query: 759  DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPEN------WEHAKYKWYLKELQDGIG 812
            + ++     FH  ++ F  WLT+AEQ L     P        ++  ++K +  E+     
Sbjct: 4683 EEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS--- 4739

Query: 813  QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 872
             R+ ++  L+ TG  +   S K D  +++  L S+  RW++V ++L +R + L++ +   
Sbjct: 4740 HREQIIE-LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRA 4798

Query: 873  SEFQRDLNEFVLWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNE 931
             +F    ++ + WLEE++      LE   +  ++K +L Q K   + L  +  +    N 
Sbjct: 4799 KQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4858

Query: 932  TGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLED 991
            TG  +     ++ ++  KL++ L +   +W  +     E+Q ++E  +   GQ    L+ 
Sbjct: 4859 TGRSLKEKTSLA-DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQA 4917

Query: 992  LEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE 1051
            L +       WL  +  QL   +QP   G  D+    I       D  +   K   L K 
Sbjct: 4918 LID-------WLYRVEPQLA-EDQP-VHGDIDLVMNLI-------DNHKAFQK--ELGKR 4959

Query: 1052 KPATQPVKRKLEDL------SSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 1105
              + Q +KR   +L       S W  V   +QEL  +                +TV  ++
Sbjct: 4960 TSSVQALKRSARELIEGSRDDSSWVKVQ--MQELSTRW---------------ETVCALS 5002

Query: 1106 QPVVTK-ETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 1164
                T+ E A+ + E             +F+     L +WL+  +Q ++   V+  D + 
Sbjct: 5003 ISKQTRLEAALRQAE-------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 5049

Query: 1165 INEMIIKQKATMQDLEQRRPQLEELITAAQNL------KNKTSNQEARTIITDRIERIQN 1218
            +  +I + K  M+ LE++R +L +  T    +       + T+ +   TII  R E +  
Sbjct: 5050 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 5109

Query: 1219 QWDEVQEHLQN------RRQQLNEMLKDSTQWLEAK-------------EEAEQVLGQAR 1259
               + Q+ L +       +Q+L E L    QW E               EE + ++ + +
Sbjct: 5110 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 5169

Query: 1260 AKLESWKEGPYTVDAIQKKITET-KQLAKDLRQWQTNVDV-----ANDLALKLLRDYSAD 1313
              +E        VD    K+T+T K+ A D    Q+++ V     A          Y + 
Sbjct: 5170 TFMEEMTRKQPDVD----KVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5225

Query: 1314 DTRKVHMITENIN---ASWRSIHKRVSEREAALEETHRLLQQ------FPLDL--EKFLA 1362
               ++      +N   + W+ +     ER   L +    L++      F  D+  +K++ 
Sbjct: 5226 SQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMR 5285

Query: 1363 WLTEAET 1369
            W+   ++
Sbjct: 5286 WMNHKKS 5292



 Score =  159 bits (401), Expect = 4e-38
 Identities = 321/1720 (18%), Positives = 690/1720 (40%), Gaps = 221/1720 (12%)

Query: 30   SAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKH 89
            S++E       + E+L  I   LA +  DK+   +  +  +++++   S+ +   E  K 
Sbjct: 1655 SSEEISTKKEQLSEALQTIQLFLAKH-GDKMTDEERNELEKQVKTLQESYNLLFSESLKQ 1713

Query: 90   NQGKEAAQRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRL---QESKMILDEVKMHLP 145
             Q  + +  V  +  +  ++ Q+   K + +       E RL   QE+ MI D   + L 
Sbjct: 1714 LQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGT-VELK 1772

Query: 146  ALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVT 205
              ++K   QE +Q  +       ++L+EV    E  +K   +   K   E+   +++++ 
Sbjct: 1773 KYQSK---QEELQKDMQGSA---QALAEVVKNTENFLKENGE---KLSQEDKALIEQKLN 1823

Query: 206  ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 265
              K+   +L  K  + K++L+K +  + K        TE +AA       ++ +E +   
Sbjct: 1824 EAKIKCEQLNLKAEQSKKELDKVVTTAIKEE------TEKVAAVKQLEESKTKIENL--- 1874

Query: 266  LDSEVAWGKATQKEIEKQKV-HLKSITEVGEALKTVLGKKETLVEDKLS--LLNSNWIAV 322
                + W     K+ E+    H + I + G   +   GK     ED+++  LL ++    
Sbjct: 1875 ----LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQ 1930

Query: 323  TSRAEEWLNLLLEYQKHMETFDQNVDHITKWII---QADTLLD-ESEKKKPQQKEDVLKR 378
                +E  NL  +YQK     ++ +      II    A  LL+ + +   P++KE + K 
Sbjct: 1931 VGTTQE--NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN 1988

Query: 379  LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP 438
            +K    +++   ++   ++   M          ++ ++ + +  +    H ++  +    
Sbjct: 1989 MK----ELKVHYETALAESEKKMK-----LTHSLQEELEKFDADYTEFEHWLQQSEQE-- 2037

Query: 439  LKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRIT 498
            L+ LE    DI  L+  L+         +++ F++D+   ++G ++ +   G+ + +   
Sbjct: 2038 LENLEAGADDINGLMTKLK---------RQKSFSEDVIS-HKGDLRYITISGNRVLEAAK 2087

Query: 499  DERKREEIKIK--------QQLLQTKHNALKDLRSQRR---KKALEISHQWYQYKRQADD 547
               KR+  K+         Q+ L    +  + L S+         ++  ++  Y+  +  
Sbjct: 2088 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 2147

Query: 548  LLKCLDDIEKKLAS-LPEP---------RDERKIKEIDRELQKKKEELNAVRRQAEGLSE 597
            LL  L   E   +  L EP         R   + K +  ++  ++  +  +++ AE L +
Sbjct: 2148 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 2207

Query: 598  DGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPS 657
              A  ++ P +  + K   +I  ++    +     ++   E+  + +T  + ++      
Sbjct: 2208 --ARGSLLPAKNDIQKTLDDIVGRYEDLSK----SVNERNEKLQITLTRSLSVQDGL--D 2259

Query: 658  TYLTEITHVSQALLEVEQL-LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 716
              L  + +V  +L E  Q+ LN+  L     +D+  +   L+      Q S   I+ ++ 
Sbjct: 2260 EMLDWMGNVESSLKEQGQVPLNSTAL-----QDIISKNIMLEQDIAGRQSS---INAMNE 2311

Query: 717  KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFN 776
            K    +++  P     LQ  +  L  ++ + +  +K+   + +    K   F    +   
Sbjct: 2312 KVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQ 2371

Query: 777  QWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD 836
             +L    Q L +  +P   +  +   Y++E      + +  +  L++  +EI      +D
Sbjct: 2372 TFLETKTQALTEVDVPGK-DVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSD 2430

Query: 837  ASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIP 896
             +++ EK  +L+ +++E+   + ++K+ +   +  L  FQ  +     W++E      I 
Sbjct: 2431 KALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIV 2490

Query: 897  LEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV--LVSAPISPEEQDKL---- 950
                  + L + LE  K L E+  L+   ++++N +G  +  L+SA  +P +        
Sbjct: 2491 QPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSG 2550

Query: 951  ------ENKLKQTNLQWI-KVSRALPEKQGEIEAQIKDLGQLEK-----------KLEDL 992
                  E     T   W  K   ++ +   +I    +DLG L K           KL+  
Sbjct: 2551 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2610

Query: 993  EEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP----------DVEEIL 1042
            +E+ + ++ WL  +      + Q     P D +  +  V+  +            V+E+ 
Sbjct: 2611 QEESSAMMQWLQKMNKTATKWQQT--PAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELK 2668

Query: 1043 SKGQHLYKEKPATQPV---KRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 1099
             K   L +E P T      K+ L ++ S+W+ +N+L  + + K  + +  LT       Q
Sbjct: 2669 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQ 2728

Query: 1100 TVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMV 1159
                + Q +V KE  +S L                          LS+   ++ +QR  V
Sbjct: 2729 ----LKQWLVEKELMVSVLGP------------------------LSIDPNMLNTQRQQV 2760

Query: 1160 GDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEA-RTIITDRIERIQN 1218
                         +  +Q+   R+PQ E+L  A Q + ++     + R I+ +++  +  
Sbjct: 2761 -------------QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQ 2807

Query: 1219 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 1278
            +WD +   L +R   +++ +  STQ+          L     KL S        DA+ ++
Sbjct: 2808 KWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQ 2867

Query: 1279 ITETKQLAKDLRQWQTNVDVA----NDLALKLLRDY-SADDTRKVHMITENINASWRSIH 1333
            +   +++ ++++Q +  + VA     DL+  +  +Y  A+ +R++  I ++     +   
Sbjct: 2868 LETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAE 2927

Query: 1334 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1393
              V   ++A   +H+  QQ   D   F AWL   +   N     + K  +LE       L
Sbjct: 2928 NHVQHLQSACASSHQ-FQQMSRD---FQAWLDTKKEEQNKSHPISAKLDVLE------SL 2977

Query: 1394 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1453
            +K  +D    + A + +Y       + +L   +GS+ A  LQ +L+ +   W    K+  
Sbjct: 2978 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA-LQLQLNTIKTNWDTFNKQVK 3036

Query: 1454 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR----QAPIGGD-----FPAVQKQN 1504
               + L+ S ++  +    ++ L  W+    + L        P  G+       ++QK+ 
Sbjct: 3037 ERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEM 3096

Query: 1505 DVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERA-QNVTRLL 1563
            D H      L      ++S  E  +  +T++    ++K+     +L  ++   +N+T+  
Sbjct: 3097 DQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 3156

Query: 1564 RKQAEEVNTEWEKLNLHSADWQRKIDETL-------ERLQELQEATDELDLKLRQAEVIK 1616
             K+ +EV+ E  K  L  A  Q  I ++L       + L  LQ     L     Q ++ K
Sbjct: 3157 -KEFQEVSKE-SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAK 3214

Query: 1617 GSWQPVGDLLIDS-----LQDHLEKVKALRGEIAPLKENV 1651
               Q   DL++++       D L +V+ +  E + L + V
Sbjct: 3215 RLAQ---DLVVEASDSKGTSDVLLQVETIAQEHSTLSQQV 3251



 Score =  149 bits (376), Expect = 3e-35
 Identities = 324/1747 (18%), Positives = 698/1747 (39%), Gaps = 230/1747 (13%)

Query: 50   KQLAAYIA-DKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-EAAQRVLSQIDVAQ 107
            K L+  IA D  +  +  +E + +Q  ++S ++++E++KK  +   +A   +L   +  Q
Sbjct: 2161 KHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 2220

Query: 108  KKLQDVSMKFRLFQKPAN-----FEQRLQESKMI---LDEVKMHLPALETKSVEQEVV-- 157
            K L D+  ++    K  N      +  L  S  +   LDE+   +  +E+   EQ  V  
Sbjct: 2221 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2280

Query: 158  -----QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYN 212
                 Q  ++  + L + ++  +S +  + +  ++ ++         L  ++  L   ++
Sbjct: 2281 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFS 2340

Query: 213  ELG-------AKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 265
            E         AK+ E K ++E    LS K++  +   T+  A T++++  +   E +   
Sbjct: 2341 EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ--ALTEVDVPGKDVTE-LSQY 2397

Query: 266  LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSR 325
            +    +     +K +E     LK I+  G      L   + LV +K + L+  +  +   
Sbjct: 2398 MQESTSEFLEHKKHLEVLHSLLKEISSHG------LPSDKALVLEKTNNLSKKFKEMEDT 2451

Query: 326  AEEWLNLLLEYQKHMETFDQNVDHITKW---------IIQ----ADTLLDESEKKKPQQK 372
             +E    +   Q+ ++ F   V  +  W         I+Q    A+ L    E  K  Q+
Sbjct: 2452 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2511

Query: 373  EDVLKRLKAE--------LNDIRPKV-------------------DSTRDQAANLMANRG 405
            +  LK  + +        L ++   V                   + T        AN+G
Sbjct: 2512 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2571

Query: 406  ---------------DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDI 449
                           +    L++ +I+ELN + + +    +   A +  L+++ +  +  
Sbjct: 2572 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2631

Query: 450  QKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIK 509
            Q+   P + E  +    + + F  ++ + N   V+EL  +   L +   D  +    K  
Sbjct: 2632 QQTPAPTDTEAVKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQM 2690

Query: 510  QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDE 568
               + +K   L  L   R++K  E S+   Q++     L + L + E  ++ L P   D 
Sbjct: 2691 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP 2750

Query: 569  RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 628
              +    +++Q   +E    + Q E L+  G  +   P +          +       + 
Sbjct: 2751 NMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGE----------DPSLRGIVKE 2800

Query: 629  NFAQIHTVREETMMVMTEDMP--LEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAK 685
              A + T + +++     D    ++ + V ST Y + +  +S  L +++  L++    + 
Sbjct: 2801 QLAAV-TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST 2859

Query: 686  DFEDLFKQEESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQ 743
              + + +Q E+ + +K  +QQ   +I +  +  +  +AL        VK +   ++L  Q
Sbjct: 2860 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQ 2911

Query: 744  WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 803
             E + K +KD + + +  V+  +        F Q   + + +L   +  +N  H      
Sbjct: 2912 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHP-ISAK 2970

Query: 804  LKELQDGIGQRQTVVRTLNAT----------GEEIIQQSSKTDASILQEKLGSLNLRWQE 853
            L  L+  I   +   +TL A           GE ++ ++  ++ + LQ +L ++   W  
Sbjct: 2971 LDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDT 3030

Query: 854  VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLE 910
              KQ+ +R+ +L+E      +++  +     W+++  +N+  I   L+P + +    KL 
Sbjct: 3031 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKL- 3089

Query: 911  QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPE 970
              K L +E+    G+++ LN T   +L    I  E     ENK                 
Sbjct: 3090 --KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK----------------- 3129

Query: 971  KQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA 1030
                          L +K++ + EQL+     L  +  + + + + ++E      + ++ 
Sbjct: 3130 -------------SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES-----KRQLQ 3171

Query: 1031 VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 1090
               +Q D+ + L    +  K     Q  ++ L+ L  +     RL Q+L  +  D     
Sbjct: 3172 CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD----- 3226

Query: 1091 TTIGASPTQTVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLL 1148
                +  T  V L  + +  + + +S+   E  S L  ++  +  F     E+    +  
Sbjct: 3227 ----SKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEF 3282

Query: 1149 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 1208
            D  + S   +  D E +     KQK T++   ++   LE L+ +  N  NKT      T 
Sbjct: 3283 DDELDSMAPVGRDAETLQ----KQKETIKAFLKK---LEALMASNDNA-NKTCKMMLATE 3334

Query: 1209 ITDR--------IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 1260
             T          +E +  Q +++ +  Q R +Q+   +K   ++    +E   +L +A  
Sbjct: 3335 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 3394

Query: 1261 KLESWKEGPYTVDAIQKKITETKQLAKD-LRQWQTNVDVANDLALKLLRDYS-ADDTRKV 1318
              ES        + I +++   K   K+ +   Q      N L   L++  + +  T+ +
Sbjct: 3395 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3454

Query: 1319 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 1378
                +++NA W++++K+V++R A L+E      +F   LE  L+W+ + E        A 
Sbjct: 3455 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----AN 3509

Query: 1379 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 1438
            +K    E  K VK  +++ + LQ  ++        +    +KI  + E +D   +L ++L
Sbjct: 3510 QKPPSAE-FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQL 3567

Query: 1439 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFP 1498
              ++ +W  L  K+      LE  S   ++ H +L+ L  WL   +  L    PIG    
Sbjct: 3568 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3627

Query: 1499 AVQKQNDVHRAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPE 1553
             +++Q   H+A + ++      +   +S  +++++  + +  + ++    + +   +  +
Sbjct: 3628 KLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3687

Query: 1554 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLK 1608
            E++ + + LL++         E   +   +W  ++ + L +L     +T+ L     +L+
Sbjct: 3688 EKSHSRSELLQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR 3746

Query: 1609 LRQAEVIKGSWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHV 1654
            + Q +++    Q V   L++ L              QD LE +KA   +I  L  +V+  
Sbjct: 3747 VLQEDILLRK-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3805

Query: 1655 NDLARQL 1661
             + A QL
Sbjct: 3806 LEQALQL 3812



 Score = 92.4 bits (228), Expect = 5e-18
 Identities = 321/1840 (17%), Positives = 702/1840 (38%), Gaps = 349/1840 (18%)

Query: 20   RQKLLEQSI--QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLT 77
            R+ LL+ S+  Q+  E E ++  +Q+ L ++D+                    ++Q D T
Sbjct: 763  RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEM-------------------QVQLDRT 803

Query: 78   SHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMIL 137
                 L  ++ H +  +   R + +                       FE  L+E+K  +
Sbjct: 804  EWGSDLPSVESHLENHKNVHRAIEE-----------------------FESSLKEAK--I 838

Query: 138  DEVKMHLPALETKSVEQEVVQSQ----LNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 193
             E++M  P   T + +   ++SQ    LN   N  + L  + + V         + +K++
Sbjct: 839  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 898

Query: 194  TENPKELDERVTAL---KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATD 250
             E   +  ER T +   K ++ EL  ++ ++++ ++   +++ ++  E +          
Sbjct: 899  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH---------- 948

Query: 251  MELTKRSAVEGMPSNLDSEVAW----GKATQKEIEKQKVHLKSITEVGEALKTVLGKKET 306
                 R  +E   + + ++ +W     +  ++ I++   + +   +  EA   +   K+ 
Sbjct: 949  ---PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDA 1005

Query: 307  LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK 366
             ++ K S   S+ I       +  +L+ E  +  E   Q    I   + +A T++    +
Sbjct: 1006 -IQRKYSCDRSSSI------HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII----Q 1054

Query: 367  KKPQQKEDVLKR---LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRF 423
             KP+  +  LK    +KA  +  + ++   +D    L  N      K++ P  +E     
Sbjct: 1055 LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPS 1114

Query: 424  AAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN----LKEEDFNKDMNEDN 479
               +      +A      +EQ   ++  L       ++  V+    + E D    +   N
Sbjct: 1115 VCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID---RIRASN 1171

Query: 480  EGTVKELL-----QRGDNLQQRITD--ERKREE--------IKIKQQLLQTKHNALKDLR 524
              ++K +L     Q   NLQ R  D  E  +E          ++++++   K    + L+
Sbjct: 1172 VASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLK 1231

Query: 525  SQRRKKALEISHQWY--QYKRQADDLLKCLDDIEKKLASLPEPRDE--------RKIKEI 574
            S  R++  E  +  Y  + +     L  C D + +++ + P  RD+         + +++
Sbjct: 1232 SAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT-PLERDDLHESVFRITEQEKL 1290

Query: 575  DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIH 634
             +EL++ K++L  +  + E      AA +  PT                           
Sbjct: 1291 KKELERLKDDLGTITNKCEEFFSQAAASSSVPT--------------------------- 1323

Query: 635  TVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLNAPDLCAKDFEDLF 691
             +R E  +V+ ++M  ++  + STY+ ++  V+  L      E L+   +    + E + 
Sbjct: 1324 -LRSELNVVL-QNMN-QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVI 1380

Query: 692  KQEESLKNIKDSLQQSSGRID----IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKV 747
              + +++N+  +L+Q    +D    + H+ +    ++    + +        LDF W K 
Sbjct: 1381 ADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKE 1440

Query: 748  NKMYKDRQGRFDRSVEKWRRFHYDIKI---------------------FNQWLTEAEQFL 786
                     + D+ VE+W+  H  I                        + W+ + E   
Sbjct: 1441 ---------KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1491

Query: 787  RKTQI--PENWEHA-----KYKWYLKEL---QDGIGQRQTVVRTLNATGEEIIQQSSKTD 836
            RK Q   PEN +       + K  + E+   Q  + + Q      +AT ++   Q+    
Sbjct: 1492 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYR 1551

Query: 837  ASILQEKLGSLNLRWQE-----VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 891
            A +  ++   +  R  +     + ++  D + R      +++++ +   + +  LEE   
Sbjct: 1552 AMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEE-- 1609

Query: 892  IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLE 951
                  E   E++ KE +E+ K L + +      LK   + G P      IS EE    +
Sbjct: 1610 ------EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1663

Query: 952  NKLKQTNLQWIKV------SRALPEKQGEIEAQIKDLGQ--------------------- 984
             +L +  LQ I++       +   E++ E+E Q+K L +                     
Sbjct: 1664 EQLSEA-LQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGD 1722

Query: 985  --LEKKL-----EDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPD 1037
              +E+K+     ++ +E+L  +   L+   N+L  + +    G   V+  +   Q+KQ +
Sbjct: 1723 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKY--QSKQEE 1780

Query: 1038 VEEILSKGQHLYKE--KPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIG 1094
            +++ +        E  K     +K   E LS E KA + + L E + K   L        
Sbjct: 1781 LQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSK 1840

Query: 1095 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD----- 1149
                + VT   +    K  A+ +LE  S   +E             L DWLS +D     
Sbjct: 1841 KELDKVVTTAIKEETEKVAAVKQLE-ESKTKIE------------NLLDWLSNVDKDSER 1887

Query: 1150 ------QVIKSQ---------RVMVGDLEDINEMIIKQKA------TMQDLEQR----RP 1184
                  QVI+           +  +G+ +++N  +++         T ++L Q+    + 
Sbjct: 1888 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1947

Query: 1185 QLEELITAAQNLKNKTSN------QEARTIITDRIERIQNQWDEVQEHLQN------RRQ 1232
            Q E++I+  Q +   T +      ++ + +  +  E++Q    E++ H +       ++ 
Sbjct: 1948 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 2007

Query: 1233 QLNEMLKDSTQWLEAK-EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQ 1291
            +L   L++  +  +A   E E  L Q+  +LE+ + G   ++ +  K+   K  ++D+  
Sbjct: 2008 KLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 2067

Query: 1292 WQTN---VDVANDLALKLLRDYSADDT---------RKVHMITENINASWRSIHKRVSER 1339
             + +   + ++ +  L+  +  S  D          R+V    ++    +RS++ + +  
Sbjct: 2068 HKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVL 2127

Query: 1340 EAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD 1399
               L++     Q +       LA L   E TA+        E +  D K ++  +++ + 
Sbjct: 2128 GNNLKDLVDKYQHYEDASCGLLAGLQACEATAS----KHLSEPIAVDPKNLQRQLEETKA 2183

Query: 1400 LQGEIEAHTDVYHNLDENSQKILRS----LEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 1455
            LQG+I +       L + ++ +L +    L   +D   +Q+ LD++  ++ +L K     
Sbjct: 2184 LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND---IQKTLDDIVGRYEDLSKSVNER 2240

Query: 1456 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ-------------- 1501
               L+ +  +   +   L E+L W+   +  L  Q  +  +  A+Q              
Sbjct: 2241 NEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIA 2300

Query: 1502 -KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 1560
             +Q+ ++   ++  K  E    ST  +++  + +      E  ++    L   E  +   
Sbjct: 2301 GRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKV 2360

Query: 1561 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 1620
             L    +E++ T  E       +      +  E  Q +QE+T E     +  EV+    +
Sbjct: 2361 ELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLK 2420

Query: 1621 PVGD--------LLIDSLQDHLEKVKALRGEIAPLKENVS 1652
             +          L+++   +  +K K +   I   KE V+
Sbjct: 2421 EISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVT 2460



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 216/1059 (20%), Positives = 424/1059 (40%), Gaps = 156/1059 (14%)

Query: 692  KQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMY 751
            K ++ L+ +KD L   + + +   S+  AA  S+ P  R +L   L  ++ Q   ++  Y
Sbjct: 1289 KLKKELERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMN-QVYSMSSTY 1345

Query: 752  KDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQD 809
             D+    +  ++  +     +K++   L E E  +      EN      +W   + E + 
Sbjct: 1346 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 1405

Query: 810  GIGQRQTVVRTLNATGEEIIQQSSKTDASI--LQEKLGSLNLRWQEVCKQLSDRKKRLEE 867
                 +  ++   A  +E+ +   + D      +EK   L  RWQ V  Q+ +R + LE 
Sbjct: 1406 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 1465

Query: 868  QKNILSEFQRDLNEFVLWLEEADNIASIPLE--PGKEQQLKEKLEQVKLLVEELPLRQGI 925
                L  ++   +    W+++ +       E  P   + L  +L Q K+LV E+ ++Q  
Sbjct: 1466 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1525

Query: 926  LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 985
            + +  +       SA +   E   +  +    + Q   V R     Q   +  I++   L
Sbjct: 1526 MDECQKYAEQY--SATVKDYELQTMTYRAMVDSQQKSPVKRR--RMQSSADLIIQEFMDL 1581

Query: 986  EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKG 1045
              +   L   +   + +      +LE      +E   + ++ E   +AK+  +++ +S  
Sbjct: 1582 RTRYTALVTLMTQYIKFAGDSLKRLE-----EEEKSLEEEKKEHVEKAKE--LQKWVSNI 1634

Query: 1046 QHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL 1103
                K  EK    P  +  + +SSE         E+  K+  L+  L TI          
Sbjct: 1635 SKTLKDAEKAGKPPFSK--QKISSE---------EISTKKEQLSEALQTI---------- 1673

Query: 1104 VTQPVVTKETAISKLEMPSSLMLEVPALAD-FNRAWTELTDWLSLLDQVIKSQRVMVGDL 1162
              Q  + K       E  + L  +V  L + +N  ++E       L Q+ +SQ    GD+
Sbjct: 1674 --QLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES------LKQLQESQTS--GDV 1723

Query: 1163 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE--RIQNQW 1220
            + + E I+ ++   Q+ +++   + +L+T  +N      +QEA  I    +E  + Q++ 
Sbjct: 1724 K-VEEKIVAER--QQEYKEKLQGICDLLTQTEN--RLIGHQEAFMIGDGTVELKKYQSKQ 1778

Query: 1221 DEVQEHLQNRRQQLNEMLKDSTQWL---------EAKEEAEQVLGQARAKLE-------- 1263
            +E+Q+ +Q   Q L E++K++  +L         E K   EQ L +A+ K E        
Sbjct: 1779 EELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQ 1838

Query: 1264 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 1323
            S KE    V    K+ TE     K L + +T ++   D    + +D     T+   +I +
Sbjct: 1839 SKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQ 1898

Query: 1324 NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQ-DATRKER 1382
            N        H +  + ++A+ E                    E E   N+L+ D   +  
Sbjct: 1899 N------GTHFQEGDGKSAIGE--------------------EDEVNGNLLETDVDGQVG 1932

Query: 1383 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1442
              +++     L +Q+Q ++ + E        +    Q ++ + + +   VLL+++   ++
Sbjct: 1933 TTQEN-----LNQQYQKVKAQHE-------KIISQHQAVIIATQSAQ--VLLEKQGQYLS 1978

Query: 1443 FKWSE-LRKKSLNIRSHLE---ASSDQWKRLHLSLQELLV-----------WLQLKDDEL 1487
             +  E L+K    ++ H E   A S++  +L  SLQE L            WLQ  + EL
Sbjct: 1979 PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL 2038

Query: 1488 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLT-EQPLEGLEKLYQ- 1545
                    D       N +    KR+    E VI    +   I ++  + LE  +   + 
Sbjct: 2039 ENLEAGADDI------NGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKR 2092

Query: 1546 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 1605
            +  ++      + V R L    +   + + K N+        + + +++ Q  ++A+  L
Sbjct: 2093 DGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLG----NNLKDLVDKYQHYEDASCGL 2148

Query: 1606 --DLKLRQAEVIKGSWQPVGDLLID--SLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 1661
               L+  +A   K   +P+    +D  +LQ  LE+ KAL+G+I+  +  V  +   A  L
Sbjct: 2149 LAGLQACEATASKHLSEPIA---VDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVL 2205

Query: 1662 TTLGIQLSPYN---LSTLEDLNTRWKLLQVAVEDRVRQL 1697
                  L P       TL+D+  R++ L  +V +R  +L
Sbjct: 2206 LDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL 2244


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score =  248 bits (632), Expect = 7e-65
 Identities = 348/1764 (19%), Positives = 734/1764 (41%), Gaps = 167/1764 (9%)

Query: 15   LNAVRRQ--KLLEQSIQSAQETEKSLHLIQESLTFIDK-QLAAYIADKVDAAQMP--QEA 69
            L A+ +Q  KLL+++    ++ E ++  ++E  + + +  +    A++ + +Q P   E 
Sbjct: 3169 LEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMET 3228

Query: 70   QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR 118
            + I   L   ++  +E  +  QGK+     L Q  I  A K          L DV+ +++
Sbjct: 3229 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWK 3288

Query: 119  -LFQKPANFEQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNH 163
             L +K A    +LQE+ +     +  L +L              +  S E +VV++Q+  
Sbjct: 3289 TLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQE 3348

Query: 164  CVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQ 223
               L + L + KS VE++ + G +I    +  +  ++ ++++ L   +  L  K   R +
Sbjct: 3349 QKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNR 3408

Query: 224  QLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQ 283
            QLE    ++++  + +  L EWL   +  L     +    S L+ ++A  KA + +I   
Sbjct: 3409 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3468

Query: 284  KVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 342
              HL     +G++LK +  +++  +V+ KL      +I +  ++     LL +   + + 
Sbjct: 3469 NKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKI 3528

Query: 343  FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 402
            F ++   +  W+ +    L  S+        + L + ++EL  ++  +   +      + 
Sbjct: 3529 FGEDEVELMNWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALL 3586

Query: 403  NRGDHCRKLVEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL-------- 452
            N  +  ++    ++  +  +  AI  R K  T  ++   K LEQ     ++L        
Sbjct: 3587 NGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3646

Query: 453  --LEPLEAEI--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDE 500
              L+ +E E+   +   LK E+ +      K++ ++  N   + + L    +    +   
Sbjct: 3647 TWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPW 3706

Query: 501  RKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLA 560
            R RE ++        ++  + D  +Q+ ++      +  Q+ + AD  L  + + EKKL 
Sbjct: 3707 RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLM 3766

Query: 561  SLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIES 620
            SL + R E+   +   +LQ +K     + R  + +  D    +        S+  ++   
Sbjct: 3767 SLGDIRLEQD--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMK 3822

Query: 621  KFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAP 680
            K       N+  I  +  E  + +     L ++    TY      +   L E + +++  
Sbjct: 3823 KKLDKVLKNYDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQL 3877

Query: 681  DLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQL 740
               A ++E L +Q+E  + +++ + +    ID ++ K    L   +P E   +QE     
Sbjct: 3878 PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAA 3936

Query: 741  DFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHA 798
            D  + ++ +  K R    D ++ +  +FH  I   +Q L   E+ + + + P +   E  
Sbjct: 3937 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVE 3993

Query: 799  KYKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRW 851
            K K  + E ++    + + Q +  TL   GEE+I +S  TD  I    +Q+KL  +   W
Sbjct: 3994 KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIW 4053

Query: 852  QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLE 910
            + +   + +R+ +L +   +  +F  D    ++ +++  +      +PG +  + K++ E
Sbjct: 4054 ENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQE 4113

Query: 911  QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRAL 968
              + + EE+   Q  L  +   G  ++ +      E DK  ++  + + N  W  +++A 
Sbjct: 4114 AAETIREEIDGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAW 4169

Query: 969  PEKQGEIEAQIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQ 1025
             ++  ++E  ++   Q +  L+   D  +     L  +SPI   LE   Q  +E    ++
Sbjct: 4170 KDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LK 4225

Query: 1026 ETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD 1085
            + +     +Q ++E +  + + L K K   +  K  ++D   E K +   L+E       
Sbjct: 4226 QFKSEAYQQQIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER------ 4278

Query: 1086 LAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWL 1145
                                  ++ ++    KLE   +L+    AL  F  A  EL  WL
Sbjct: 4279 ----------------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWL 4307

Query: 1146 SLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEA 1205
            +  + ++  Q+ + GD + I   + K      D+   +  +E +  A  +L   ++ +EA
Sbjct: 4308 THTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEA 4367

Query: 1206 RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESW 1265
              +  +++E +  +W  V E  + R+QQL+  L+ +  +    E+ +Q L      L + 
Sbjct: 4368 SNL-QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLAS 4426

Query: 1266 KEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENI 1325
            K      +  ++++    ++       +           ++L          +     N+
Sbjct: 4427 KPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNL 4486

Query: 1326 NASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLE 1385
               W S+  +++ER+  LEE   L  +F   L+ F+ WLT+AE T NV   A+R   +L+
Sbjct: 4487 KEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILD 4543

Query: 1386 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 1445
                V   + + +    E+ +H +    LD+     L+      D VL++  L ++  +W
Sbjct: 4544 T---VLFQIDEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRW 4599

Query: 1446 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 1505
             ++ ++ +     L+ +  + K+ H +  +L+ WL+  +  L  +  I  D   ++ Q  
Sbjct: 4600 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4659

Query: 1506 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 1565
             H+ F++ L  K  V  +T  T                    R L  +    +    L  
Sbjct: 4660 QHKEFQKSLGAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDD 4700

Query: 1566 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GD 1624
               E+  +W+ +   S + Q K++E L    +  +A   L   L + E      QPV GD
Sbjct: 4701 MLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD 4760

Query: 1625 LLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWK 1684
              ID + + ++  KA + E+     +V  +   AR+L       S +    +++L+TRW+
Sbjct: 4761 --IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWE 4818

Query: 1685 LL-------QVAVEDRVRQLHEAH 1701
             +       Q  +E  +RQ  E H
Sbjct: 4819 TVCALSISKQTRLEAALRQAEEFH 4842



 Score =  216 bits (549), Expect = 3e-55
 Identities = 302/1617 (18%), Positives = 647/1617 (40%), Gaps = 189/1617 (11%)

Query: 97   QRVLSQIDVAQKKLQDVSMKFRLFQK---PAN-----FEQRLQESKMILDEV-KMHLPAL 147
            + +L++ +   ++L+ +S+  + F +   P N      E+RL   + I  +  K+     
Sbjct: 3397 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3456

Query: 148  ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTAL 207
            + K++E +++    NH  +L++++S  +S   +  +  + +VQ K           +   
Sbjct: 3457 QHKALEDDII----NHNKHLHQAVSIGQSLKVLSSREDKDMVQSK-----------LDFS 3501

Query: 208  KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 267
            ++ Y E+  K   R + L++ L  ++   ++   L  WL     +L+K S  +     L 
Sbjct: 3502 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3561

Query: 268  SEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 326
             + +  +  Q++I  +K ++      G E LK   G +  +++DKL  + + +  +T  +
Sbjct: 3562 KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3621

Query: 327  EEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDVL---KRLKA 381
             +    L +  +         + +  W+  ++ + L  E++  K ++        K LK 
Sbjct: 3622 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3681

Query: 382  ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI--KTGKASIPL 439
            E  + +  +DS  + ++ L+       R+ +E  ++E N R+  +S  I  K  +    +
Sbjct: 3682 EAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3741

Query: 440  KELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED---NEGTVKE 485
               +QF+              +KL+   +  ++Q     +    K    +   ++  + +
Sbjct: 3742 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDD 3801

Query: 486  LLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQA 545
            L++ G  +    ++E K + +K K   +   ++ +  + S+R  +         Q+    
Sbjct: 3802 LVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETY 3860

Query: 546  DDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEELNAVRRQAEG 594
            ++L   L + +  ++ LP P            + R+++E+  E +   +++N    Q   
Sbjct: 3861 EELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 3920

Query: 595  LSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISY 654
            LS  G   +++   +     + +I+      ++   A    + + T      D  LE   
Sbjct: 3921 LSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDKIDQILESLE 3976

Query: 655  VPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDII 714
                 L +   +S  + ++++ ++     + D E L    E+LK   + +   SG  D  
Sbjct: 3977 RIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4036

Query: 715  HSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI 774
             S K              +Q+ L Q+ F WE ++ + ++R+ +    +E   +F  D   
Sbjct: 4037 ISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMS 4083

Query: 775  FNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGE 826
                + + + F+R  + P        +  E A+    ++E  DG+ +   +V  L   G 
Sbjct: 4084 LIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDIVINL---GS 4137

Query: 827  EIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWL 886
            E+I    + D  I+++ +  LN  W  + K   DR  +LEE      ++Q  L     W+
Sbjct: 4138 ELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWV 4197

Query: 887  EEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPE 945
            + A   +AS+       + +K+++E++K    E   +Q  +++LN     +L       E
Sbjct: 4198 DIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT---E 4254

Query: 946  EQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 1003
            E DK  +++ L +  L W  +   +  +Q ++E  +  LGQ +  L++L       L WL
Sbjct: 4255 ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-------LAWL 4307

Query: 1004 SPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQHLYKEKPAT 1055
            +     L    Q    G     E E+A        V A Q  VE +   G  L +     
Sbjct: 4308 THTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGE 4365

Query: 1056 QP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKET 1113
            +   ++ KLE L+  W+ V                                      ++T
Sbjct: 4366 EASNLQNKLEVLNQRWQNV-------------------------------------LEKT 4388

Query: 1114 AISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK 1173
               K ++  +L         F+    +L  WL+  ++ + + + + G  E   E +    
Sbjct: 4389 EQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM 4444

Query: 1174 ATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 1233
                  E +    + L+   Q +  +   + A T I   I  ++ +W+ V+  L  R+ +
Sbjct: 4445 EVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVETKLNERKTK 4503

Query: 1234 LNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 1293
            L E L  + ++  + ++    L QA   L         +D +  +I E K  A ++   +
Sbjct: 4504 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHR 4563

Query: 1294 TNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQF 1353
              +   +     L       D   +  +  ++ + W  + +R+ ER  +L++  +  +QF
Sbjct: 4564 EQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQF 4623

Query: 1354 PLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHN 1413
                 K + WL E+E + +       +  +  D   +K  + Q ++ Q  + A   VY  
Sbjct: 4624 HEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDT 4677

Query: 1414 LDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSL 1473
             +   + +      +DD + L   L  +  KW  +  KS+  ++ LE +     +   +L
Sbjct: 4678 TNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4737

Query: 1474 QELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLT 1533
            Q L+ WL   + +L+   P+ GD   V    D H+AF++EL  +                
Sbjct: 4738 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT--------------- 4782

Query: 1534 EQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLE 1593
                  ++ L +  REL   E +++ +  ++ Q +E++T WE +   S   Q +++  L 
Sbjct: 4783 ----SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALR 4836

Query: 1594 RLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVKALRGEI 1644
            + +E       L   L +AE        + D       LID  ++ ++K++  R E+
Sbjct: 4837 QAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAEL 4893



 Score =  212 bits (540), Expect = 3e-54
 Identities = 302/1584 (19%), Positives = 628/1584 (39%), Gaps = 175/1584 (11%)

Query: 102  QIDVAQKKLQDVSMKFRLFQKPAN-----FEQRLQESKMI----------LDEVKMHLPA 146
            ++ + Q KL+ +  +++   K +       EQ LQ ++ +          LD+V++ L +
Sbjct: 3599 EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLS 3658

Query: 147  LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTA 206
             ET+ ++ E           L K     K+ ++ + +    +++       + L++ V  
Sbjct: 3659 YETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE 3718

Query: 207  LKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNL 266
                Y  +   +T++ ++++  +  S++  +  +    W+  T+ +L     +       
Sbjct: 3719 DNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT 3778

Query: 267  DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSR 325
             +++   K    EI + K  +  + + G  + T   ++E   ++ KL  +  N+  +   
Sbjct: 3779 SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQI 3838

Query: 326  AEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD-------ESEKKKPQQKED-VLK 377
              E    L   Q  +  F +  + +  W+ +  +++        E E  + QQ+E   L+
Sbjct: 3839 NSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLR 3898

Query: 378  RLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASI 437
             L AE      K++ T  Q   L    G      ++ +    +  ++ I   +K    ++
Sbjct: 3899 ELIAEHKPHIDKMNKTGPQLLELSPGEGFS----IQEKYVAADTLYSQIKEDVKKRAVAL 3954

Query: 438  P--LKELEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTV------- 483
               + +  QF+  I ++LE LE  +++      ++ + E   + ++E+   +V       
Sbjct: 3955 DEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQP 4014

Query: 484  --KELLQRGDNLQQRITDERKREEIKIKQQLLQTK---HNALKDLRSQRRKKALEISHQW 538
              + L QRG+ +  R     K    K  Q  L         +  L  +R  K L++    
Sbjct: 4015 LYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4074

Query: 539  YQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKKEELNAVRRQAE---G 594
             ++      L+  + D +  +  L +P  D   +K+     +  +EE++ ++ + +    
Sbjct: 4075 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVIN 4134

Query: 595  LSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISY 654
            L  +  A   EP +  + K   E+ S +    +    +I  + EE M    +        
Sbjct: 4135 LGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL-EEAMQAAVQ-------- 4185

Query: 655  VPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDII 714
                Y   +  V   +      L +      D E + +Q E LK  K    Q    ++ +
Sbjct: 4186 ----YQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERL 4241

Query: 715  HSKKTAALQSATPV-ERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 773
            + +    L+  T   ++  +Q+ L +L   W+ + +   +RQ + + ++    +F + + 
Sbjct: 4242 NHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4301

Query: 774  IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQ 830
                WLT  E  L + Q P   +    +  L +   LQ+ +   Q+ V  +N  G ++I+
Sbjct: 4302 ELLAWLTHTEGLLSE-QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIE 4360

Query: 831  QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 890
             S+  +AS LQ KL  LN RWQ V ++   RK++L+        F  ++ +   WL + +
Sbjct: 4361 SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTE 4420

Query: 891  N--IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQ- 947
               +AS PL  G  +  KE+L     +      ++   K L + G  +L   P S E   
Sbjct: 4421 RHLLASKPLG-GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4479

Query: 948  DKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIR 1007
            D+  N LK+   +W  V   L E++ ++E  +    +    L+D        + WL+   
Sbjct: 4480 DQDINNLKE---KWESVETKLNERKTKLEEALNLAMEFHNSLQDF-------INWLTQAE 4529

Query: 1008 NQLEIYNQPN---QEGPFDVQETEI---AVQAKQPDVEEILSKGQHL--YKEKPATQPVK 1059
              L + ++P+       F + E ++    V + +  + E+   G HL  + +K     +K
Sbjct: 4530 QTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK 4589

Query: 1060 RKLEDLSSEW-KAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKL 1118
              L  + S W K V RL++  R                                      
Sbjct: 4590 NLLISVQSRWEKVVQRLVERGR-------------------------------------- 4611

Query: 1119 EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD 1178
                SL         F+ AW++L +WL   ++ + S+  +  D + I   + + K   + 
Sbjct: 4612 ----SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKS 4667

Query: 1179 LEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEML 1238
            L  +    +      ++LK KTS  +    + D +  ++++WD +      R+ +L E L
Sbjct: 4668 LGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEAL 4727

Query: 1239 KDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDV 1298
              S Q+ +A +     L +   +L   +     +D +   I   K   K+L +  ++V  
Sbjct: 4728 LFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQA 4787

Query: 1299 ANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLE 1358
                A +L+   S DD+  V +  + ++  W ++      ++  LE   R  ++F   + 
Sbjct: 4788 LKRSARELIEG-SRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVH 4846

Query: 1359 KFLAWLTEAETTAN---VLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLD 1415
              L WL EAE T     VL D     R L D    KE MK+ ++ + E+   T +   + 
Sbjct: 4847 ALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQH--KEFMKKLEEKRAELNKATTMGDTV- 4903

Query: 1416 ENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE 1475
                    ++   D    ++  +  +  ++ E+   +   +  L ++          L+ 
Sbjct: 4904 -------LAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEA 4956

Query: 1476 LLVWLQLKDDELSRQAP--IGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVR---- 1529
            LL WLQ  +  L+ +    I  +   V+     H+ F  E+  K+P +    +T +    
Sbjct: 4957 LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAA 5016

Query: 1530 --------IFLTEQPLEGLEK-----LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 1576
                    I + ++   G ++     LY    +   E +   V  L+ K        W++
Sbjct: 5017 DPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSK--------WQQ 5068

Query: 1577 LNLHSADWQRKIDETLERLQELQE 1600
            + L + + +RK+++ L+RL+EL+E
Sbjct: 5069 VWLLALERRRKLNDALDRLEELRE 5092



 Score =  206 bits (525), Expect = 2e-52
 Identities = 321/1772 (18%), Positives = 710/1772 (40%), Gaps = 195/1772 (11%)

Query: 22   KLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEI 81
            K L Q +    E   S     E++T   K+      +     Q  +E   I   L S   
Sbjct: 2951 KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAY 3010

Query: 82   SLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF--------------RLFQKPANFE 127
            S + +      +++ Q +  Q+D+A++  QD+ ++                + Q+ +   
Sbjct: 3011 SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS 3070

Query: 128  QRLQESKMILD---------------------EVKMHLPALETKSVEQEVVQSQLNHCVN 166
            Q++ E    L+                     E    L ++     + E +Q Q      
Sbjct: 3071 QQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKA 3130

Query: 167  LYKSLSEVKSEVEMVIKTGRQIVQKKQTE-NPKELDERVTALKLHYNELGAKVTERKQQL 225
              K L  + +  +   KT + ++  ++T  +   +   + AL    N+L  +   R++Q+
Sbjct: 3131 FLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3190

Query: 226  EKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQK-EIEKQK 284
            E  +K   +   ++   +  L   +     +  V      ++ ++   K  QK EIE  +
Sbjct: 3191 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3250

Query: 285  VHLKSITEVGEALKTVLGKKETL--VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 342
               + +  +G+ L     K  +   +E  L  +N+ W  +  +  +    L E   H   
Sbjct: 3251 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3310

Query: 343  FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 402
            F   ++ +  W++  + L+  + +K P  +  V+K    E   ++  +D  R     ++ 
Sbjct: 3311 FQDALESLLSWMVDTEELV--ANQKPPSAEFKVVKAQIQEQKLLQRLLDD-RKSTVEVIK 3367

Query: 403  NRGDHCRKLVEP--------QISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 454
              G+      EP        Q+S L+ R+ A+ ++ +T       ++LE  +   Q+  E
Sbjct: 3368 REGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN-----RQLEGISVVAQQFHE 3422

Query: 455  PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK--REEIKIKQQL 512
             LE   +    +++   N +        ++E + +   L+  I +  K   + + I Q L
Sbjct: 3423 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL 3482

Query: 513  LQTKHNALKDLRSQRRKKALEISHQWY-QYKRQADDLLKCLDDIEKKLASLPEPRDERKI 571
                    KD+   +    L+ S  WY + + ++    + L           E  DE ++
Sbjct: 3483 KVLSSREDKDMVQSK----LDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGE--DEVEL 3536

Query: 572  KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 631
                 E+  K  +L+      EGL +  + + V    I L K  + ++        LN  
Sbjct: 3537 MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK--QNVDQAL-----LNGL 3589

Query: 632  QI--HTVREETMMVMTEDMPLEISYVPSTYL-TEITHVSQALLEVEQLLNA--PDLCA-- 684
            ++   T  +E +++  +   ++  Y   T L T++    +  L++ + L++   +LC   
Sbjct: 3590 ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWL 3649

Query: 685  -------KDFE-DLFKQEESL------KNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 730
                     +E  + K EE+       K +K   + +   +D ++   +A L+      R
Sbjct: 3650 DKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAR 3709

Query: 731  VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK-- 788
              L++ +++ + ++  V+     +    D ++ + ++F         W+TE E+ L    
Sbjct: 3710 EGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLG 3769

Query: 789  -TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSL 847
              ++ ++   A+ +   K     I + + ++  L  +G +I+   S+ +   +++KL  +
Sbjct: 3770 DIRLEQDQTSAQLQ-VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKV 3828

Query: 848  NLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIAS-IPLEPGKEQQLK 906
               +  +C+  S+R  +LE  ++++++F     E   WL E  +I S +P    + + L+
Sbjct: 3829 LKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLR 3888

Query: 907  EKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSR 966
            ++ E+ + L E +   +  + ++N+TG  +L    +SP E   ++ K    +  + ++  
Sbjct: 3889 QQQEEHRQLRELIAEHKPHIDKMNKTGPQLL---ELSPGEGFSIQEKYVAADTLYSQIKE 3945

Query: 967  ALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL-SPIRNQLEIYNQPNQEGPFDVQ 1025
             + ++   ++  I    Q   K++ + E L  ++  L  P     E+  +  +E   + +
Sbjct: 3946 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEV--EKIKEQISENK 4003

Query: 1026 ETEIAVQAKQPDVEEILSKGQHLYKEKPAT------QPVKRKLEDLSSEWKAVNRLLQEL 1079
               + ++  QP  E +  +G+ +      T      + V+ KL+ +   W+ ++ L++E 
Sbjct: 4004 NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEER 4063

Query: 1080 RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 1139
             AK                                          +L+V  LA+  + W 
Sbjct: 4064 EAK------------------------------------------LLDVMELAE--KFW- 4078

Query: 1140 ELTDWLSLLDQVIKSQRVMVGDLED--INEMIIK-QKATMQDLEQRRPQLEELITAAQNL 1196
               D +SL+   IK  +  + DLED  I+  ++K Q+   + + +    L+E +    NL
Sbjct: 4079 --CDHMSLI-VTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 4135

Query: 1197 KNK---TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 1253
             ++      +  + I+   I+ + + WD + +  ++R  +L E ++ + Q+ +  +    
Sbjct: 4136 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 4195

Query: 1254 VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 1313
             +  A  KL S       ++ ++++I E KQ   +  Q Q  ++  N  A  LL+  + +
Sbjct: 4196 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4255

Query: 1314 -DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN 1372
             D   V      +   W S+ +R+  R+  LE     L QF   L++ LAWLT  E    
Sbjct: 4256 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL-- 4313

Query: 1373 VLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAV 1432
                 + ++ +  D K ++  + +   LQ ++ AH      +++    ++ S  G ++A 
Sbjct: 4314 ----LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG-EEAS 4368

Query: 1433 LLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP 1492
             LQ +L+ +N +W  + +K+   +  L+ +  Q K  H  +++L  WL   +  L    P
Sbjct: 4369 NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKP 4428

Query: 1493 IGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP 1552
            +GG     ++Q +VH       + KE    S ++  +  L   P      + Q+   L  
Sbjct: 4429 LGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNL-- 4486

Query: 1553 EERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQA 1612
                                +WE +     + + K++E L    E   +  +    L QA
Sbjct: 4487 ------------------KEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQA 4528

Query: 1613 E-VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPY 1671
            E  +  + +P   L++D++   +++ K    E+   +E +  ++     L     +    
Sbjct: 4529 EQTLNVASRP--SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4586

Query: 1672 NL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 1702
             + + L  + +RW+ +   + +R R L +A +
Sbjct: 4587 LIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4618



 Score =  198 bits (503), Expect = 6e-50
 Identities = 343/1820 (18%), Positives = 730/1820 (40%), Gaps = 205/1820 (11%)

Query: 24   LEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE---AQKIQSDLTSHE 80
            ++Q+I  + + +  L  + + L+ +D +L++ +A       M Q+   AQK++ ++   +
Sbjct: 2645 IDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEK 2704

Query: 81   ISL---------------EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN 125
              +               EE  K    ++    + S  DV QK    V            
Sbjct: 2705 KQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2764

Query: 126  FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTG 185
            F+Q  ++ +  LD  K         S + +V++S +    +  K+L+      E  I  G
Sbjct: 2765 FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEG 2824

Query: 186  RQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEW 245
              ++ K Q      L  ++  +K +++    +V ER+ +L++ L+ + K ++++  L  W
Sbjct: 2825 ENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2884

Query: 246  LAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKK 304
            +      L + +  ++  P+  ++ +A  K+ QKE+++    ++ +     +L +V    
Sbjct: 2885 IDKCQNNLEEIKFCLD--PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2942

Query: 305  ETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDES 364
            + +V D+   L      VT +       L    +  + F +      + +  A   LD  
Sbjct: 2943 KEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH 3002

Query: 365  EKKKPQQKED----VLKRLKAELNDIRPKVDSTRDQAANLMANRGD-HCRKLVEPQISEL 419
            +    Q   +    +L+  +  L  ++ +VD  +  A +L+    D      V  Q+  +
Sbjct: 3003 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETI 3062

Query: 420  NHRFAAISHRI--KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNE 477
                + +S ++  K       L+ +  F + I+++         +  ++     + +  +
Sbjct: 3063 AQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQ 3122

Query: 478  DNEGTVKELLQR-------GDNLQQR-----ITDERKREEIKIKQQL--LQTKHNALKDL 523
              + T+K  L++        DN  +       T+E   + + IK+ L  L  + N L D 
Sbjct: 3123 KQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLD- 3181

Query: 524  RSQRRKKALEIS----HQWYQYKRQADDLLKCLDDIEK-------KLASLPEPRDERKI- 571
            R+Q R++ +E +     ++Y   ++   LL+  ++ E+       +  ++ +  +  K+ 
Sbjct: 3182 RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVF 3241

Query: 572  -KEIDRELQKKKEELNAVRRQAEGLSEDGA----AMAVEPTQIQLSKRWREIESKFAQ-F 625
             KE    LQ K++++N +    +GL +  A       +E     ++ RW+ +  K AQ  
Sbjct: 3242 QKEEIEPLQGKQQDVNWL---GQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRA 3298

Query: 626  RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 685
             +L  A +H  R                     +   +  +   +++ E+L+      + 
Sbjct: 3299 AQLQEALLHCGR---------------------FQDALESLLSWMVDTEELVANQKPPSA 3337

Query: 686  DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 745
            +F+ +  Q +  K ++  L      +++I  +      +A P ++VK+ + LS LD +WE
Sbjct: 3338 EFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWE 3397

Query: 746  KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL- 804
             +    + R  + +      ++FH  ++  N+WLT  E+ L   + P   + +K +  + 
Sbjct: 3398 ALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE-PIGTQASKLEEQIA 3456

Query: 805  --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 862
              K L+D I      +    + G+ +   SS+ D  ++Q KL    + + E+ ++   R 
Sbjct: 3457 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3516

Query: 863  KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIPLEPGKEQQLKEKLEQVKLLVEELPL 921
            + L++       F  D  E + WL E  D ++ + ++    + L ++  ++++L E++ L
Sbjct: 3517 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3576

Query: 922  R-----QGILKQL----NETGGPVLV------SAPISPEEQDKLENKLKQTNLQWIKVSR 966
            R     Q +L  L      TG  VL+      +     ++  KL   + +T  Q ++++R
Sbjct: 3577 RKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3636

Query: 967  ALPEKQGEI--------------EAQI-------------KDLGQLEKKLEDLEEQLNHL 999
             L     E+              E Q+             K+L +  K  + L + LN +
Sbjct: 3637 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEV 3696

Query: 1000 ---LLWLSP--IRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPA 1054
               LL L P   R  LE     + E    V +T   +  K  +++  + + Q   +   A
Sbjct: 3697 SSALLELVPWRAREGLEKMVAEDNERYRLVSDT---ITQKVEEIDAAILRSQQFDQAADA 3753

Query: 1055 -------TQPVKRKLEDLSSEWKAVNRLLQELRA------KQPDLAPGL--------TTI 1093
                   T+     L D+  E    +  LQ  +       +  D+   L        T  
Sbjct: 3754 ELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3813

Query: 1094 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW---TELTDWLSLLDQ 1150
                 Q++      V+     I ++     L LE  A +  N+ W    EL  WL+    
Sbjct: 3814 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE-RAQSLVNQFWETYEELWPWLTETQS 3872

Query: 1151 VIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIIT 1210
            +I        + E + +   + +   + + + +P ++++      L   +  +     I 
Sbjct: 3873 IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS--IQ 3930

Query: 1211 DRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP- 1269
            ++       + +++E ++ R   L+E +  STQ+    ++ +Q+L      +E  ++ P 
Sbjct: 3931 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQF---HDKIDQILESLERIVERLRQPPS 3987

Query: 1270 --YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL-RDYSADDTRKVHMITENIN 1326
                V+ I+++I+E K ++ D+ + Q   +       +++ R    D       + + ++
Sbjct: 3988 ISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLD 4047

Query: 1327 AS---WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 1383
                 W +IH  V EREA L +   L ++F  D    +  + + +     L+D      +
Sbjct: 4048 QMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSV 4107

Query: 1384 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 1443
            ++  +   E ++  +++ G ++   D+  NL       L +  G  D  ++++ +D +N 
Sbjct: 4108 VKQQQEAAETIR--EEIDG-LQEELDIVINLGSE----LIAACGEPDKPIVKKSIDELNS 4160

Query: 1444 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 1503
             W  L K   +    LE +     +    LQ +  W+ +   +L+  +PIG D   V++Q
Sbjct: 4161 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4220

Query: 1504 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 1563
             +  + FK E                    +Q +E +E+L  +   L  +   ++    +
Sbjct: 4221 IEELKQFKSE------------------AYQQQIE-MERLNHQAELLLKKVTEESDKHTV 4261

Query: 1564 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 1623
            +    E+   W+ L     + Q K++  L  L + Q A DEL   L   E +    +PVG
Sbjct: 4262 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4321

Query: 1624 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTR 1682
                 +++  L K   L+ ++   +  V  VN     L          NL + LE LN R
Sbjct: 4322 G-DPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4380

Query: 1683 WKLLQVAVEDRVRQLHEAHR 1702
            W+ +    E R +QL  A R
Sbjct: 4381 WQNVLEKTEQRKQQLDGALR 4400



 Score =  191 bits (486), Expect = 6e-48
 Identities = 304/1643 (18%), Positives = 676/1643 (41%), Gaps = 168/1643 (10%)

Query: 36   KSLHLIQESLTFIDKQLAAYIADKVDA---AQMPQEAQKIQSDLTSHEISLEEMKKH-NQ 91
            ++L   +E++    K+L A +A   +A    +M    ++   DL   +  LE + K  N+
Sbjct: 3119 ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK 3178

Query: 92   GKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKS 151
              + AQ    Q++   K+L++             F  +L+E  ++L + + H  +     
Sbjct: 3179 LLDRAQAREEQVEGTIKRLEE-------------FYSKLKEFSILLQKAEEHEESQGPVG 3225

Query: 152  VEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTALKL 209
            +E E +  QLN      K  +  ++ + + V   G+ ++Q   ++ + + L+  +  +  
Sbjct: 3226 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3285

Query: 210  HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 269
             +  L  KV +R  QL++ L    + +  +  L  W+  T+  +  +         + ++
Sbjct: 3286 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQ 3345

Query: 270  VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEE 328
            +   K  Q+ ++ +K  ++ I   GE + T     + + +  +LSLL+S W A+ ++AE 
Sbjct: 3346 IQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAET 3405

Query: 329  WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELNDI 386
                L       + F + ++ + +W+   +  L   E    Q    E+ + + KA  +DI
Sbjct: 3406 RNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDI 3465

Query: 387  RPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 441
                          Q+  ++++R D  + +V+ ++      F+ + + I+  + S    E
Sbjct: 3466 INHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSRSE 3517

Query: 442  LEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRITD 499
            L Q      K+    E E+   +N   +  +K   +D   EG  K+        + R+  
Sbjct: 3518 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRVLQ 3571

Query: 500  ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL 559
            E   + +  KQ + Q   N L+ L+     + L I  +    K +  D+ K   D+ K L
Sbjct: 3572 E---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3628

Query: 560  ASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWRE 617
                +    R++     EL     K E+  +  + + L  + A+ A +    +L K  + 
Sbjct: 3629 EQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEAKN 3685

Query: 618  IESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 673
             ++       ++ A +  V    RE    ++ ED       V  T   ++  +  A+L  
Sbjct: 3686 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAILRS 3744

Query: 674  EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV-- 731
            +Q   A D       +  K+  SL +I+    Q+S ++ +  +     L+    ++ +  
Sbjct: 3745 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3804

Query: 732  ---KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ--------- 777
               K+  A S+ + Q   +K++K+ K+       + E++ +      + NQ         
Sbjct: 3805 SGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELW 3864

Query: 778  -WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK 834
             WLTE +  + +   P  E     + +   ++L++ I + +  +  +N TG ++++ S  
Sbjct: 3865 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3924

Query: 835  TDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADNIA 893
               SI QEK  + +  + ++ + +  R   L+E  +  ++F   +++ +  LE   + + 
Sbjct: 3925 EGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 3983

Query: 894  SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDKLE 951
              P    + +++KE++ + K +  ++   Q + + L + G  ++  +  + ++     ++
Sbjct: 3984 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4043

Query: 952  NKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIRNQ 1009
            +KL Q    W  +   + E+    EA++ D+ +L +K        +H  L++ +   ++ 
Sbjct: 4044 DKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQDF 4094

Query: 1010 LEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVKRK 1061
            +     P  +     Q+ E A      +   Q +++ +++ G  L     +P    VK+ 
Sbjct: 4095 IRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS 4154

Query: 1062 LEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMP 1121
            +++L+S W ++N+  ++                                    I KLE  
Sbjct: 4155 IDELNSAWDSLNKAWKD-----------------------------------RIDKLEEA 4179

Query: 1122 SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 1181
                  + A   +      + DW+ +    + S   +  DLE + + I + K    +  Q
Sbjct: 4180 ------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4233

Query: 1182 RRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDS 1241
            ++ ++E L   A+ L  K + +  +  + D +  ++  WD ++E + NR+ +L   L   
Sbjct: 4234 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4293

Query: 1242 TQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVAND 1301
             Q+  A +E    L      L   K       AI+ ++ +   L  D+   Q+ V+  N 
Sbjct: 4294 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4353

Query: 1302 LALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFL 1361
                L+   + ++   +    E +N  W+++ ++  +R+  L+   R  + F  ++E   
Sbjct: 4354 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQ 4413

Query: 1362 AWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKI 1421
             WLT+ E      +     + L    +  KE +    ++    EA  + Y +L +  Q++
Sbjct: 4414 QWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQM 4467

Query: 1422 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 1481
            L     S +   + + ++N+  KW  +  K    ++ LE + +     H SLQ+ + WL 
Sbjct: 4468 LARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4526

Query: 1482 LKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQPLE 1538
              +  L+  +        V  Q D H+ F  E+ +    I+   +T   ++ F  +Q + 
Sbjct: 4527 QAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4586

Query: 1539 GLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQRKI 1588
             ++ L      +  + R + V + L          RK+A++ +  W KL     +W  + 
Sbjct: 4587 LIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLEES 4637

Query: 1589 DETLERLQELQEATDELDLKLRQ 1611
            +++L+   E+    D++  +L Q
Sbjct: 4638 EKSLDSELEIANDPDKIKTQLAQ 4660



 Score =  176 bits (447), Expect = 2e-43
 Identities = 370/1827 (20%), Positives = 735/1827 (40%), Gaps = 273/1827 (14%)

Query: 21   QKLLEQSIQSAQETEKSL-HLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSH 79
            QK ++ S Q+  E  K+  + ++E+   + ++  A I  K++ A++  E   ++++ +  
Sbjct: 1604 QKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKK 1663

Query: 80   EISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDE 139
            E+   +       KE  ++V +   + + K +  ++   L     + E+   + K ++++
Sbjct: 1664 EL---DKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQ 1720

Query: 140  VKMHLPALETKSV---EQEVVQSQLNHCV---------NLYKSLSEVKSEVEMVIKTGRQ 187
               H    + KS    E EV  + L   V         NL +   +VK++ E +I   + 
Sbjct: 1721 NGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQA 1780

Query: 188  IVQKKQT--------------ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS- 232
            ++   Q+              E  ++L + +  LK+HY E     +E+K +L   L+   
Sbjct: 1781 VIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHY-ETALAESEKKMKLTHSLQEEL 1839

Query: 233  RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 292
             K   +      WL  ++ EL    A     + L +++   K+  +++   K  L+ IT 
Sbjct: 1840 EKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITI 1899

Query: 293  VG----EALKTVL----GKKETL-----VEDKLSLLNSNWIAVTSRAEEWLN----LLLE 335
             G    EA K+      GK +T      V+ KL      + ++ S+     N    L+ +
Sbjct: 1900 SGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK 1959

Query: 336  YQKHMETFDQNVDHITKWIIQADTLLDES---EKKKPQQKEDVLKRLKAELNDIRPKVDS 392
            YQ + +     +  +      A   L E    + K  Q++ +  K L+ +++  +  V+ 
Sbjct: 1960 YQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEK 2019

Query: 393  TRDQAANLMANRGD--HCRKLVEPQISELNHRFAAISHRIK------------------- 431
             +  A  L+  RG     +  ++  + ++  R+  +S  +                    
Sbjct: 2020 LKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDG 2079

Query: 432  -------TGKASIPLKELEQF---NSDIQKLLEP---LEAEI---QQGVNLKEEDFNKDM 475
                    G     LKE  Q    ++ +Q ++     LE +I   Q  +N   E   K M
Sbjct: 2080 LDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFM 2139

Query: 476  NEDNEGTVKELLQRGDNLQQRITD-ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEI 534
               +  T   L  +  +L  R ++   K +E   K + L+TK    ++L S++ +  LE 
Sbjct: 2140 ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL-SEKLQTFLET 2198

Query: 535  SHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQ--A 592
              Q           L  +D   K +  L +   E   + +  E +K  E L+++ ++  +
Sbjct: 2199 KTQ----------ALTEVDVPGKDVTELSQYMQESTSEFL--EHKKHLEVLHSLLKEISS 2246

Query: 593  EGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEI 652
             GL  D  A+ +E T   LSK+++E+E               T++E+   V +    L+ 
Sbjct: 2247 HGLPSD-KALVLEKTN-NLSKKFKEMED--------------TIKEKKEAVTSCQEQLDA 2290

Query: 653  SYVPSTYLTE-ITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEE--SLKNIKDSLQQSSG 709
              V    L   I   ++ +  V+    A DL  K  ED  K +E  SLK  +     +SG
Sbjct: 2291 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDL-GKSLEDTKKLQEKWSLKTPEIQKVNNSG 2349

Query: 710  RIDIIH--------SKKTAALQS----------ATPVER-------VKLQEALSQLDFQW 744
             I + +        +K  AA++S          AT  E          +++ ++ +   +
Sbjct: 2350 -ISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2408

Query: 745  EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK---TQIPENWEHAKYK 801
            E +  + KD+    +  + K ++   +     QWL +  +   K   T  P + E  K +
Sbjct: 2409 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2468

Query: 802  -WYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKT-DASILQEKLGSLNLRWQEVCKQLS 859
                K  +  + Q    V+ L     E+++++  T +A   ++ L  ++ +WQE+ +   
Sbjct: 2469 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2528

Query: 860  DRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASI--PLEPGKEQQLKEKLEQVKLLVE 917
            DR+++LEE  N L++FQ    +   WL E + + S+  PL       L  + +QV++L++
Sbjct: 2529 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQ 2587

Query: 918  ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 977
            E   R+   +QL   G  +L      P  +  ++ +L     +W  ++  L ++   I+ 
Sbjct: 2588 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2647

Query: 978  QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPD 1037
             I    Q +  L  L ++L+ L   LS   + L +   P+       Q+ E A + KQ  
Sbjct: 2648 AIVKSTQYQSLLRSLSDKLSDLDNKLS---SSLAVSTHPDAMN----QQLETAQKMKQEI 2700

Query: 1038 VEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGA 1095
             +E   +   Q L ++  A    +    +LS + + + +  +++  K  +    L +  A
Sbjct: 2701 QQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACA 2760

Query: 1096 SPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 1155
            S  Q                                  F +   +   WL    +     
Sbjct: 2761 SSHQ----------------------------------FQQMSRDFQAWLDTKKEEQNKS 2786

Query: 1156 RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIER 1215
              +   L+ +  +I   K   + L  +    E+ I   +NL  KT   E +  +  ++  
Sbjct: 2787 HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSE-KAALQLQLNT 2845

Query: 1216 IQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 1275
            I+  WD   + ++ R  +L E L+ + ++ E  E     + + +  LE  K   + +D  
Sbjct: 2846 IKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIK---FCLDPA 2902

Query: 1276 --QKKITETKQLAKDLRQWQTNVDVANDLALKLL------RDYSADDTR----KVHMITE 1323
              +  I + K L K++ Q    V++ N+ A  LL      ++   D+ +    KV M+TE
Sbjct: 2903 EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE 2962

Query: 1324 NINAS---WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 1380
             +++      ++ ++  E +   +E+ R LQ     L+               + D+   
Sbjct: 2963 QLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD---------------IHDSLGS 3007

Query: 1381 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDN 1440
            +     +K +  L  Q + LQ  ++   D+   L ++        +G+ D +L   +++ 
Sbjct: 3008 QAY--SNKYLTMLQTQQKSLQA-LKHQVDLAKRLAQDLVVEASDSKGTSDVLL---QVET 3061

Query: 1441 MNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAV 1500
            +  + S L ++     S LE           +++E+       DDEL   AP+G D   +
Sbjct: 3062 IAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETL 3121

Query: 1501 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 1560
            QKQ +  +AF ++L+       +  +T ++ L                    EE + ++ 
Sbjct: 3122 QKQKETIKAFLKKLEALMASNDNANKTCKMMLA------------------TEETSPDLV 3163

Query: 1561 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 1620
              +++  E ++ +  KL   +   + +++ T++RL+E      E  + L++AE  + S  
Sbjct: 3164 G-IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQG 3222

Query: 1621 PVGDLLIDSLQDHLEKVKAL-RGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST---- 1675
            PVG +  +++   L   K   + EI PL+     VN L + L    IQ +  + ST    
Sbjct: 3223 PVG-METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL----IQSAAKSTSTQGLE 3277

Query: 1676 --LEDLNTRWKLLQVAVEDRVRQLHEA 1700
              L+D+N RWK L   V  R  QL EA
Sbjct: 3278 HDLDDVNARWKTLNKKVAQRAAQLQEA 3304



 Score =  161 bits (407), Expect = 8e-39
 Identities = 282/1447 (19%), Positives = 579/1447 (40%), Gaps = 202/1447 (13%)

Query: 33   ETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS-HEISLEEMKKHNQ 91
            ETEK L  + +     D+  A     K    ++ +    I   + S H+I     ++  Q
Sbjct: 3760 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ 3819

Query: 92   G-KEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN-FEQRLQESKMILDEVKMHLPALET 149
              K+   +VL   D   +   +  ++    Q   N F +  +E    L E +  +  L  
Sbjct: 3820 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3879

Query: 150  KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 209
             ++E E ++ Q      L + ++E K  ++ + KTG Q+++    E    + E+  A   
Sbjct: 3880 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG-FSIQEKYVAADT 3938

Query: 210  HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 269
             Y+++   V +R   L++ +  S +   +++ + E L      L +  ++      +  +
Sbjct: 3939 LYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 3998

Query: 270  VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-----LVEDKLSLLNSNWIAVTS 324
            ++  K    ++EK +   +++ + GE +    G  +       V+DKL  +   W  + +
Sbjct: 3999 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4058

Query: 325  RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP-------QQKEDVLK 377
              EE    LL+  +  E F    DH++  +   DT     + + P       +Q+++  +
Sbjct: 4059 LVEEREAKLLDVMELAEKFW--CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4116

Query: 378  RLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT--GKA 435
             ++ E++ ++ ++D   +  + L+A  G+  + +V+  I ELN  + +++   K    K 
Sbjct: 4117 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4176

Query: 436  SIPLKELEQFNSDIQKL--------------------LEPLEAEIQQGVNLKEEDFNKDM 475
               ++   Q+   +Q +                    LE ++ +I++    K E + + +
Sbjct: 4177 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4236

Query: 476  NEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEIS 535
                   ++ L  + + L +++T+E  +  ++     L+   ++L++    R+ K     
Sbjct: 4237 E------MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGAL 4290

Query: 536  HQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEID--------RELQKKKEELNA 587
                Q++   D+LL  L   E  L+       + K  EI+         ++   +  + A
Sbjct: 4291 LALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEA 4350

Query: 588  VRRQAEGLSEDGAAMAVEPTQIQL---SKRWREIESKFAQFRR-----LNFAQ-IHTVRE 638
            V +    L E  A       Q +L   ++RW+ +  K  Q ++     L  A+  H   E
Sbjct: 4351 VNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIE 4410

Query: 639  ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 698
            +    +T+     ++  P   L E           EQL    ++CA  FE    +EE+ K
Sbjct: 4411 DLQQWLTDTERHLLASKPLGGLPETAK--------EQLNVHMEVCAA-FE---AKEETYK 4458

Query: 699  NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 758
            ++    QQ   R       K+A            + + ++ L  +WE V     +R+ + 
Sbjct: 4459 SLMQKGQQMLARCP-----KSA---------ETNIDQDINNLKEKWESVETKLNERKTKL 4504

Query: 759  DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPEN------WEHAKYKWYLKELQDGIG 812
            + ++     FH  ++ F  WLT+AEQ L     P        ++  ++K +  E+     
Sbjct: 4505 EEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS--- 4561

Query: 813  QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 872
             R+ ++  L+ TG  +   S K D  +++  L S+  RW++V ++L +R + L++ +   
Sbjct: 4562 HREQIIE-LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRA 4620

Query: 873  SEFQRDLNEFVLWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNE 931
             +F    ++ + WLEE++      LE   +  ++K +L Q K   + L  +  +    N 
Sbjct: 4621 KQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4680

Query: 932  TGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLED 991
            TG  +     ++ ++  KL++ L +   +W  +     E+Q ++E  +   GQ    L+ 
Sbjct: 4681 TGRSLKEKTSLA-DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQA 4739

Query: 992  LEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE 1051
            L +       WL  +  QL   +QP   G  D+    I       D  +   K   L K 
Sbjct: 4740 LID-------WLYRVEPQLA-EDQP-VHGDIDLVMNLI-------DNHKAFQK--ELGKR 4781

Query: 1052 KPATQPVKRKLEDL------SSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 1105
              + Q +KR   +L       S W  V   +QEL  +                +TV  ++
Sbjct: 4782 TSSVQALKRSARELIEGSRDDSSWVKVQ--MQELSTRW---------------ETVCALS 4824

Query: 1106 QPVVTK-ETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 1164
                T+ E A+ + E             +F+     L +WL+  +Q ++   V+  D + 
Sbjct: 4825 ISKQTRLEAALRQAE-------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4871

Query: 1165 INEMIIKQKATMQDLEQRRPQLEELITAAQNL------KNKTSNQEARTIITDRIERIQN 1218
            +  +I + K  M+ LE++R +L +  T    +       + T+ +   TII  R E +  
Sbjct: 4872 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 4931

Query: 1219 QWDEVQEHLQN------RRQQLNEMLKDSTQWLEAK-------------EEAEQVLGQAR 1259
               + Q+ L +       +Q+L E L    QW E               EE + ++ + +
Sbjct: 4932 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 4991

Query: 1260 AKLESWKEGPYTVDAIQKKITET-KQLAKDLRQWQTNVDV-----ANDLALKLLRDYSAD 1313
              +E        VD    K+T+T K+ A D    Q+++ V     A          Y + 
Sbjct: 4992 TFMEEMTRKQPDVD----KVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5047

Query: 1314 DTRKVHMITENIN---ASWRSIHKRVSEREAALEETHRLLQQ------FPLDL--EKFLA 1362
               ++      +N   + W+ +     ER   L +    L++      F  D+  +K++ 
Sbjct: 5048 SQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMR 5107

Query: 1363 WLTEAET 1369
            W+   ++
Sbjct: 5108 WMNHKKS 5114



 Score =  159 bits (401), Expect = 4e-38
 Identities = 321/1720 (18%), Positives = 690/1720 (40%), Gaps = 221/1720 (12%)

Query: 30   SAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKH 89
            S++E       + E+L  I   LA +  DK+   +  +  +++++   S+ +   E  K 
Sbjct: 1477 SSEEISTKKEQLSEALQTIQLFLAKH-GDKMTDEERNELEKQVKTLQESYNLLFSESLKQ 1535

Query: 90   NQGKEAAQRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRL---QESKMILDEVKMHLP 145
             Q  + +  V  +  +  ++ Q+   K + +       E RL   QE+ MI D   + L 
Sbjct: 1536 LQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGT-VELK 1594

Query: 146  ALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVT 205
              ++K   QE +Q  +       ++L+EV    E  +K   +   K   E+   +++++ 
Sbjct: 1595 KYQSK---QEELQKDMQGSA---QALAEVVKNTENFLKENGE---KLSQEDKALIEQKLN 1645

Query: 206  ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 265
              K+   +L  K  + K++L+K +  + K        TE +AA       ++ +E +   
Sbjct: 1646 EAKIKCEQLNLKAEQSKKELDKVVTTAIKEE------TEKVAAVKQLEESKTKIENL--- 1696

Query: 266  LDSEVAWGKATQKEIEKQKV-HLKSITEVGEALKTVLGKKETLVEDKLS--LLNSNWIAV 322
                + W     K+ E+    H + I + G   +   GK     ED+++  LL ++    
Sbjct: 1697 ----LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQ 1752

Query: 323  TSRAEEWLNLLLEYQKHMETFDQNVDHITKWII---QADTLLD-ESEKKKPQQKEDVLKR 378
                +E  NL  +YQK     ++ +      II    A  LL+ + +   P++KE + K 
Sbjct: 1753 VGTTQE--NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN 1810

Query: 379  LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP 438
            +K    +++   ++   ++   M          ++ ++ + +  +    H ++  +    
Sbjct: 1811 MK----ELKVHYETALAESEKKMK-----LTHSLQEELEKFDADYTEFEHWLQQSEQE-- 1859

Query: 439  LKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRIT 498
            L+ LE    DI  L+  L+         +++ F++D+   ++G ++ +   G+ + +   
Sbjct: 1860 LENLEAGADDINGLMTKLK---------RQKSFSEDVIS-HKGDLRYITISGNRVLEAAK 1909

Query: 499  DERKREEIKIK--------QQLLQTKHNALKDLRSQRR---KKALEISHQWYQYKRQADD 547
               KR+  K+         Q+ L    +  + L S+         ++  ++  Y+  +  
Sbjct: 1910 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1969

Query: 548  LLKCLDDIEKKLAS-LPEP---------RDERKIKEIDRELQKKKEELNAVRRQAEGLSE 597
            LL  L   E   +  L EP         R   + K +  ++  ++  +  +++ AE L +
Sbjct: 1970 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 2029

Query: 598  DGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPS 657
              A  ++ P +  + K   +I  ++    +     ++   E+  + +T  + ++      
Sbjct: 2030 --ARGSLLPAKNDIQKTLDDIVGRYEDLSK----SVNERNEKLQITLTRSLSVQDGL--D 2081

Query: 658  TYLTEITHVSQALLEVEQL-LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 716
              L  + +V  +L E  Q+ LN+  L     +D+  +   L+      Q S   I+ ++ 
Sbjct: 2082 EMLDWMGNVESSLKEQGQVPLNSTAL-----QDIISKNIMLEQDIAGRQSS---INAMNE 2133

Query: 717  KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFN 776
            K    +++  P     LQ  +  L  ++ + +  +K+   + +    K   F    +   
Sbjct: 2134 KVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQ 2193

Query: 777  QWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD 836
             +L    Q L +  +P   +  +   Y++E      + +  +  L++  +EI      +D
Sbjct: 2194 TFLETKTQALTEVDVPGK-DVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSD 2252

Query: 837  ASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIP 896
             +++ EK  +L+ +++E+   + ++K+ +   +  L  FQ  +     W++E      I 
Sbjct: 2253 KALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIV 2312

Query: 897  LEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV--LVSAPISPEEQDKL---- 950
                  + L + LE  K L E+  L+   ++++N +G  +  L+SA  +P +        
Sbjct: 2313 QPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSG 2372

Query: 951  ------ENKLKQTNLQWI-KVSRALPEKQGEIEAQIKDLGQLEK-----------KLEDL 992
                  E     T   W  K   ++ +   +I    +DLG L K           KL+  
Sbjct: 2373 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2432

Query: 993  EEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP----------DVEEIL 1042
            +E+ + ++ WL  +      + Q     P D +  +  V+  +            V+E+ 
Sbjct: 2433 QEESSAMMQWLQKMNKTATKWQQT--PAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELK 2490

Query: 1043 SKGQHLYKEKPATQPV---KRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 1099
             K   L +E P T      K+ L ++ S+W+ +N+L  + + K  + +  LT       Q
Sbjct: 2491 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQ 2550

Query: 1100 TVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMV 1159
                + Q +V KE  +S L                          LS+   ++ +QR  V
Sbjct: 2551 ----LKQWLVEKELMVSVLGP------------------------LSIDPNMLNTQRQQV 2582

Query: 1160 GDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEA-RTIITDRIERIQN 1218
                         +  +Q+   R+PQ E+L  A Q + ++     + R I+ +++  +  
Sbjct: 2583 -------------QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQ 2629

Query: 1219 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 1278
            +WD +   L +R   +++ +  STQ+          L     KL S        DA+ ++
Sbjct: 2630 KWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQ 2689

Query: 1279 ITETKQLAKDLRQWQTNVDVA----NDLALKLLRDY-SADDTRKVHMITENINASWRSIH 1333
            +   +++ ++++Q +  + VA     DL+  +  +Y  A+ +R++  I ++     +   
Sbjct: 2690 LETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAE 2749

Query: 1334 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1393
              V   ++A   +H+  QQ   D   F AWL   +   N     + K  +LE       L
Sbjct: 2750 NHVQHLQSACASSHQ-FQQMSRD---FQAWLDTKKEEQNKSHPISAKLDVLE------SL 2799

Query: 1394 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1453
            +K  +D    + A + +Y       + +L   +GS+ A  LQ +L+ +   W    K+  
Sbjct: 2800 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA-LQLQLNTIKTNWDTFNKQVK 2858

Query: 1454 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR----QAPIGGD-----FPAVQKQN 1504
               + L+ S ++  +    ++ L  W+    + L        P  G+       ++QK+ 
Sbjct: 2859 ERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEM 2918

Query: 1505 DVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERA-QNVTRLL 1563
            D H      L      ++S  E  +  +T++    ++K+     +L  ++   +N+T+  
Sbjct: 2919 DQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 2978

Query: 1564 RKQAEEVNTEWEKLNLHSADWQRKIDETL-------ERLQELQEATDELDLKLRQAEVIK 1616
             K+ +EV+ E  K  L  A  Q  I ++L       + L  LQ     L     Q ++ K
Sbjct: 2979 -KEFQEVSKE-SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAK 3036

Query: 1617 GSWQPVGDLLIDS-----LQDHLEKVKALRGEIAPLKENV 1651
               Q   DL++++       D L +V+ +  E + L + V
Sbjct: 3037 RLAQ---DLVVEASDSKGTSDVLLQVETIAQEHSTLSQQV 3073



 Score =  149 bits (376), Expect = 3e-35
 Identities = 324/1747 (18%), Positives = 698/1747 (39%), Gaps = 230/1747 (13%)

Query: 50   KQLAAYIA-DKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-EAAQRVLSQIDVAQ 107
            K L+  IA D  +  +  +E + +Q  ++S ++++E++KK  +   +A   +L   +  Q
Sbjct: 1983 KHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 2042

Query: 108  KKLQDVSMKFRLFQKPAN-----FEQRLQESKMI---LDEVKMHLPALETKSVEQEVV-- 157
            K L D+  ++    K  N      +  L  S  +   LDE+   +  +E+   EQ  V  
Sbjct: 2043 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2102

Query: 158  -----QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYN 212
                 Q  ++  + L + ++  +S +  + +  ++ ++         L  ++  L   ++
Sbjct: 2103 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFS 2162

Query: 213  ELG-------AKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 265
            E         AK+ E K ++E    LS K++  +   T+  A T++++  +   E +   
Sbjct: 2163 EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ--ALTEVDVPGKDVTE-LSQY 2219

Query: 266  LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSR 325
            +    +     +K +E     LK I+  G      L   + LV +K + L+  +  +   
Sbjct: 2220 MQESTSEFLEHKKHLEVLHSLLKEISSHG------LPSDKALVLEKTNNLSKKFKEMEDT 2273

Query: 326  AEEWLNLLLEYQKHMETFDQNVDHITKW---------IIQ----ADTLLDESEKKKPQQK 372
             +E    +   Q+ ++ F   V  +  W         I+Q    A+ L    E  K  Q+
Sbjct: 2274 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2333

Query: 373  EDVLKRLKAE--------LNDIRPKV-------------------DSTRDQAANLMANRG 405
            +  LK  + +        L ++   V                   + T        AN+G
Sbjct: 2334 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2393

Query: 406  ---------------DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDI 449
                           +    L++ +I+ELN + + +    +   A +  L+++ +  +  
Sbjct: 2394 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2453

Query: 450  QKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIK 509
            Q+   P + E  +    + + F  ++ + N   V+EL  +   L +   D  +    K  
Sbjct: 2454 QQTPAPTDTEAVKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQM 2512

Query: 510  QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDE 568
               + +K   L  L   R++K  E S+   Q++     L + L + E  ++ L P   D 
Sbjct: 2513 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP 2572

Query: 569  RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 628
              +    +++Q   +E    + Q E L+  G  +   P +          +       + 
Sbjct: 2573 NMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGE----------DPSLRGIVKE 2622

Query: 629  NFAQIHTVREETMMVMTEDMP--LEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAK 685
              A + T + +++     D    ++ + V ST Y + +  +S  L +++  L++    + 
Sbjct: 2623 QLAAV-TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST 2681

Query: 686  DFEDLFKQEESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQ 743
              + + +Q E+ + +K  +QQ   +I +  +  +  +AL        VK +   ++L  Q
Sbjct: 2682 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQ 2733

Query: 744  WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 803
             E + K +KD + + +  V+  +        F Q   + + +L   +  +N  H      
Sbjct: 2734 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHP-ISAK 2792

Query: 804  LKELQDGIGQRQTVVRTLNAT----------GEEIIQQSSKTDASILQEKLGSLNLRWQE 853
            L  L+  I   +   +TL A           GE ++ ++  ++ + LQ +L ++   W  
Sbjct: 2793 LDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDT 2852

Query: 854  VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLE 910
              KQ+ +R+ +L+E      +++  +     W+++  +N+  I   L+P + +    KL 
Sbjct: 2853 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKL- 2911

Query: 911  QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPE 970
              K L +E+    G+++ LN T   +L    I  E     ENK                 
Sbjct: 2912 --KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK----------------- 2951

Query: 971  KQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA 1030
                          L +K++ + EQL+     L  +  + + + + ++E      + ++ 
Sbjct: 2952 -------------SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES-----KRQLQ 2993

Query: 1031 VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 1090
               +Q D+ + L    +  K     Q  ++ L+ L  +     RL Q+L  +  D     
Sbjct: 2994 CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD----- 3048

Query: 1091 TTIGASPTQTVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLL 1148
                +  T  V L  + +  + + +S+   E  S L  ++  +  F     E+    +  
Sbjct: 3049 ----SKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEF 3104

Query: 1149 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 1208
            D  + S   +  D E +     KQK T++   ++   LE L+ +  N  NKT      T 
Sbjct: 3105 DDELDSMAPVGRDAETLQ----KQKETIKAFLKK---LEALMASNDNA-NKTCKMMLATE 3156

Query: 1209 ITDR--------IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 1260
             T          +E +  Q +++ +  Q R +Q+   +K   ++    +E   +L +A  
Sbjct: 3157 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 3216

Query: 1261 KLESWKEGPYTVDAIQKKITETKQLAKD-LRQWQTNVDVANDLALKLLRDYS-ADDTRKV 1318
              ES        + I +++   K   K+ +   Q      N L   L++  + +  T+ +
Sbjct: 3217 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3276

Query: 1319 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 1378
                +++NA W++++K+V++R A L+E      +F   LE  L+W+ + E        A 
Sbjct: 3277 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----AN 3331

Query: 1379 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 1438
            +K    E  K VK  +++ + LQ  ++        +    +KI  + E +D   +L ++L
Sbjct: 3332 QKPPSAE-FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQL 3389

Query: 1439 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFP 1498
              ++ +W  L  K+      LE  S   ++ H +L+ L  WL   +  L    PIG    
Sbjct: 3390 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3449

Query: 1499 AVQKQNDVHRAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPE 1553
             +++Q   H+A + ++      +   +S  +++++  + +  + ++    + +   +  +
Sbjct: 3450 KLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3509

Query: 1554 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLK 1608
            E++ + + LL++         E   +   +W  ++ + L +L     +T+ L     +L+
Sbjct: 3510 EKSHSRSELLQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR 3568

Query: 1609 LRQAEVIKGSWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHV 1654
            + Q +++    Q V   L++ L              QD LE +KA   +I  L  +V+  
Sbjct: 3569 VLQEDILLRK-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3627

Query: 1655 NDLARQL 1661
             + A QL
Sbjct: 3628 LEQALQL 3634



 Score = 92.4 bits (228), Expect = 5e-18
 Identities = 321/1840 (17%), Positives = 702/1840 (38%), Gaps = 349/1840 (18%)

Query: 20   RQKLLEQSI--QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLT 77
            R+ LL+ S+  Q+  E E ++  +Q+ L ++D+                    ++Q D T
Sbjct: 585  RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEM-------------------QVQLDRT 625

Query: 78   SHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMIL 137
                 L  ++ H +  +   R + +                       FE  L+E+K  +
Sbjct: 626  EWGSDLPSVESHLENHKNVHRAIEE-----------------------FESSLKEAK--I 660

Query: 138  DEVKMHLPALETKSVEQEVVQSQ----LNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 193
             E++M  P   T + +   ++SQ    LN   N  + L  + + V         + +K++
Sbjct: 661  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720

Query: 194  TENPKELDERVTAL---KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATD 250
             E   +  ER T +   K ++ EL  ++ ++++ ++   +++ ++  E +          
Sbjct: 721  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH---------- 770

Query: 251  MELTKRSAVEGMPSNLDSEVAW----GKATQKEIEKQKVHLKSITEVGEALKTVLGKKET 306
                 R  +E   + + ++ +W     +  ++ I++   + +   +  EA   +   K+ 
Sbjct: 771  ---PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDA 827

Query: 307  LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK 366
             ++ K S   S+ I       +  +L+ E  +  E   Q    I   + +A T++    +
Sbjct: 828  -IQRKYSCDRSSSI------HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII----Q 876

Query: 367  KKPQQKEDVLKR---LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRF 423
             KP+  +  LK    +KA  +  + ++   +D    L  N      K++ P  +E     
Sbjct: 877  LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPS 936

Query: 424  AAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN----LKEEDFNKDMNEDN 479
               +      +A      +EQ   ++  L       ++  V+    + E D    +   N
Sbjct: 937  VCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID---RIRASN 993

Query: 480  EGTVKELL-----QRGDNLQQRITD--ERKREE--------IKIKQQLLQTKHNALKDLR 524
              ++K +L     Q   NLQ R  D  E  +E          ++++++   K    + L+
Sbjct: 994  VASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLK 1053

Query: 525  SQRRKKALEISHQWY--QYKRQADDLLKCLDDIEKKLASLPEPRDE--------RKIKEI 574
            S  R++  E  +  Y  + +     L  C D + +++ + P  RD+         + +++
Sbjct: 1054 SAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT-PLERDDLHESVFRITEQEKL 1112

Query: 575  DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIH 634
             +EL++ K++L  +  + E      AA +  PT                           
Sbjct: 1113 KKELERLKDDLGTITNKCEEFFSQAAASSSVPT--------------------------- 1145

Query: 635  TVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLNAPDLCAKDFEDLF 691
             +R E  +V+ ++M  ++  + STY+ ++  V+  L      E L+   +    + E + 
Sbjct: 1146 -LRSELNVVL-QNMN-QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVI 1202

Query: 692  KQEESLKNIKDSLQQSSGRID----IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKV 747
              + +++N+  +L+Q    +D    + H+ +    ++    + +        LDF W K 
Sbjct: 1203 ADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKE 1262

Query: 748  NKMYKDRQGRFDRSVEKWRRFHYDIKI---------------------FNQWLTEAEQFL 786
                     + D+ VE+W+  H  I                        + W+ + E   
Sbjct: 1263 ---------KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1313

Query: 787  RKTQI--PENWEHA-----KYKWYLKEL---QDGIGQRQTVVRTLNATGEEIIQQSSKTD 836
            RK Q   PEN +       + K  + E+   Q  + + Q      +AT ++   Q+    
Sbjct: 1314 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYR 1373

Query: 837  ASILQEKLGSLNLRWQE-----VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 891
            A +  ++   +  R  +     + ++  D + R      +++++ +   + +  LEE   
Sbjct: 1374 AMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEE-- 1431

Query: 892  IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLE 951
                  E   E++ KE +E+ K L + +      LK   + G P      IS EE    +
Sbjct: 1432 ------EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1485

Query: 952  NKLKQTNLQWIKV------SRALPEKQGEIEAQIKDLGQ--------------------- 984
             +L +  LQ I++       +   E++ E+E Q+K L +                     
Sbjct: 1486 EQLSEA-LQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGD 1544

Query: 985  --LEKKL-----EDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPD 1037
              +E+K+     ++ +E+L  +   L+   N+L  + +    G   V+  +   Q+KQ +
Sbjct: 1545 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKY--QSKQEE 1602

Query: 1038 VEEILSKGQHLYKE--KPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIG 1094
            +++ +        E  K     +K   E LS E KA + + L E + K   L        
Sbjct: 1603 LQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSK 1662

Query: 1095 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD----- 1149
                + VT   +    K  A+ +LE  S   +E             L DWLS +D     
Sbjct: 1663 KELDKVVTTAIKEETEKVAAVKQLE-ESKTKIE------------NLLDWLSNVDKDSER 1709

Query: 1150 ------QVIKSQ---------RVMVGDLEDINEMIIKQKA------TMQDLEQR----RP 1184
                  QVI+           +  +G+ +++N  +++         T ++L Q+    + 
Sbjct: 1710 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1769

Query: 1185 QLEELITAAQNLKNKTSN------QEARTIITDRIERIQNQWDEVQEHLQN------RRQ 1232
            Q E++I+  Q +   T +      ++ + +  +  E++Q    E++ H +       ++ 
Sbjct: 1770 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1829

Query: 1233 QLNEMLKDSTQWLEAK-EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQ 1291
            +L   L++  +  +A   E E  L Q+  +LE+ + G   ++ +  K+   K  ++D+  
Sbjct: 1830 KLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 1889

Query: 1292 WQTN---VDVANDLALKLLRDYSADDT---------RKVHMITENINASWRSIHKRVSER 1339
             + +   + ++ +  L+  +  S  D          R+V    ++    +RS++ + +  
Sbjct: 1890 HKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVL 1949

Query: 1340 EAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD 1399
               L++     Q +       LA L   E TA+        E +  D K ++  +++ + 
Sbjct: 1950 GNNLKDLVDKYQHYEDASCGLLAGLQACEATAS----KHLSEPIAVDPKNLQRQLEETKA 2005

Query: 1400 LQGEIEAHTDVYHNLDENSQKILRS----LEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 1455
            LQG+I +       L + ++ +L +    L   +D   +Q+ LD++  ++ +L K     
Sbjct: 2006 LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND---IQKTLDDIVGRYEDLSKSVNER 2062

Query: 1456 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ-------------- 1501
               L+ +  +   +   L E+L W+   +  L  Q  +  +  A+Q              
Sbjct: 2063 NEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIA 2122

Query: 1502 -KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 1560
             +Q+ ++   ++  K  E    ST  +++  + +      E  ++    L   E  +   
Sbjct: 2123 GRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKV 2182

Query: 1561 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 1620
             L    +E++ T  E       +      +  E  Q +QE+T E     +  EV+    +
Sbjct: 2183 ELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLK 2242

Query: 1621 PVGD--------LLIDSLQDHLEKVKALRGEIAPLKENVS 1652
             +          L+++   +  +K K +   I   KE V+
Sbjct: 2243 EISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVT 2282



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 216/1059 (20%), Positives = 424/1059 (40%), Gaps = 156/1059 (14%)

Query: 692  KQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMY 751
            K ++ L+ +KD L   + + +   S+  AA  S+ P  R +L   L  ++ Q   ++  Y
Sbjct: 1111 KLKKELERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMN-QVYSMSSTY 1167

Query: 752  KDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQD 809
             D+    +  ++  +     +K++   L E E  +      EN      +W   + E + 
Sbjct: 1168 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 1227

Query: 810  GIGQRQTVVRTLNATGEEIIQQSSKTDASI--LQEKLGSLNLRWQEVCKQLSDRKKRLEE 867
                 +  ++   A  +E+ +   + D      +EK   L  RWQ V  Q+ +R + LE 
Sbjct: 1228 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 1287

Query: 868  QKNILSEFQRDLNEFVLWLEEADNIASIPLE--PGKEQQLKEKLEQVKLLVEELPLRQGI 925
                L  ++   +    W+++ +       E  P   + L  +L Q K+LV E+ ++Q  
Sbjct: 1288 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1347

Query: 926  LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 985
            + +  +       SA +   E   +  +    + Q   V R     Q   +  I++   L
Sbjct: 1348 MDECQKYAEQY--SATVKDYELQTMTYRAMVDSQQKSPVKRR--RMQSSADLIIQEFMDL 1403

Query: 986  EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKG 1045
              +   L   +   + +      +LE      +E   + ++ E   +AK+  +++ +S  
Sbjct: 1404 RTRYTALVTLMTQYIKFAGDSLKRLE-----EEEKSLEEEKKEHVEKAKE--LQKWVSNI 1456

Query: 1046 QHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL 1103
                K  EK    P  +  + +SSE         E+  K+  L+  L TI          
Sbjct: 1457 SKTLKDAEKAGKPPFSK--QKISSE---------EISTKKEQLSEALQTI---------- 1495

Query: 1104 VTQPVVTKETAISKLEMPSSLMLEVPALAD-FNRAWTELTDWLSLLDQVIKSQRVMVGDL 1162
              Q  + K       E  + L  +V  L + +N  ++E       L Q+ +SQ    GD+
Sbjct: 1496 --QLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES------LKQLQESQTS--GDV 1545

Query: 1163 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE--RIQNQW 1220
            + + E I+ ++   Q+ +++   + +L+T  +N      +QEA  I    +E  + Q++ 
Sbjct: 1546 K-VEEKIVAER--QQEYKEKLQGICDLLTQTEN--RLIGHQEAFMIGDGTVELKKYQSKQ 1600

Query: 1221 DEVQEHLQNRRQQLNEMLKDSTQWL---------EAKEEAEQVLGQARAKLE-------- 1263
            +E+Q+ +Q   Q L E++K++  +L         E K   EQ L +A+ K E        
Sbjct: 1601 EELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQ 1660

Query: 1264 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 1323
            S KE    V    K+ TE     K L + +T ++   D    + +D     T+   +I +
Sbjct: 1661 SKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQ 1720

Query: 1324 NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQ-DATRKER 1382
            N        H +  + ++A+ E                    E E   N+L+ D   +  
Sbjct: 1721 N------GTHFQEGDGKSAIGE--------------------EDEVNGNLLETDVDGQVG 1754

Query: 1383 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1442
              +++     L +Q+Q ++ + E        +    Q ++ + + +   VLL+++   ++
Sbjct: 1755 TTQEN-----LNQQYQKVKAQHE-------KIISQHQAVIIATQSAQ--VLLEKQGQYLS 1800

Query: 1443 FKWSE-LRKKSLNIRSHLE---ASSDQWKRLHLSLQELLV-----------WLQLKDDEL 1487
             +  E L+K    ++ H E   A S++  +L  SLQE L            WLQ  + EL
Sbjct: 1801 PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL 1860

Query: 1488 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLT-EQPLEGLEKLYQ- 1545
                    D       N +    KR+    E VI    +   I ++  + LE  +   + 
Sbjct: 1861 ENLEAGADDI------NGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKR 1914

Query: 1546 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 1605
            +  ++      + V R L    +   + + K N+        + + +++ Q  ++A+  L
Sbjct: 1915 DGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLG----NNLKDLVDKYQHYEDASCGL 1970

Query: 1606 --DLKLRQAEVIKGSWQPVGDLLID--SLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 1661
               L+  +A   K   +P+    +D  +LQ  LE+ KAL+G+I+  +  V  +   A  L
Sbjct: 1971 LAGLQACEATASKHLSEPIA---VDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVL 2027

Query: 1662 TTLGIQLSPYN---LSTLEDLNTRWKLLQVAVEDRVRQL 1697
                  L P       TL+D+  R++ L  +V +R  +L
Sbjct: 2028 LDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL 2066


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score =  248 bits (632), Expect = 7e-65
 Identities = 348/1764 (19%), Positives = 734/1764 (41%), Gaps = 167/1764 (9%)

Query: 15   LNAVRRQ--KLLEQSIQSAQETEKSLHLIQESLTFIDK-QLAAYIADKVDAAQMP--QEA 69
            L A+ +Q  KLL+++    ++ E ++  ++E  + + +  +    A++ + +Q P   E 
Sbjct: 2843 LEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMET 2902

Query: 70   QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR 118
            + I   L   ++  +E  +  QGK+     L Q  I  A K          L DV+ +++
Sbjct: 2903 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWK 2962

Query: 119  -LFQKPANFEQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNH 163
             L +K A    +LQE+ +     +  L +L              +  S E +VV++Q+  
Sbjct: 2963 TLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQE 3022

Query: 164  CVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQ 223
               L + L + KS VE++ + G +I    +  +  ++ ++++ L   +  L  K   R +
Sbjct: 3023 QKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNR 3082

Query: 224  QLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQ 283
            QLE    ++++  + +  L EWL   +  L     +    S L+ ++A  KA + +I   
Sbjct: 3083 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3142

Query: 284  KVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 342
              HL     +G++LK +  +++  +V+ KL      +I +  ++     LL +   + + 
Sbjct: 3143 NKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKI 3202

Query: 343  FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 402
            F ++   +  W+ +    L  S+        + L + ++EL  ++  +   +      + 
Sbjct: 3203 FGEDEVELMNWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALL 3260

Query: 403  NRGDHCRKLVEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL-------- 452
            N  +  ++    ++  +  +  AI  R K  T  ++   K LEQ     ++L        
Sbjct: 3261 NGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3320

Query: 453  --LEPLEAEI--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDE 500
              L+ +E E+   +   LK E+ +      K++ ++  N   + + L    +    +   
Sbjct: 3321 TWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPW 3380

Query: 501  RKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLA 560
            R RE ++        ++  + D  +Q+ ++      +  Q+ + AD  L  + + EKKL 
Sbjct: 3381 RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLM 3440

Query: 561  SLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIES 620
            SL + R E+   +   +LQ +K     + R  + +  D    +        S+  ++   
Sbjct: 3441 SLGDIRLEQD--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMK 3496

Query: 621  KFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAP 680
            K       N+  I  +  E  + +     L ++    TY      +   L E + +++  
Sbjct: 3497 KKLDKVLKNYDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQL 3551

Query: 681  DLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQL 740
               A ++E L +Q+E  + +++ + +    ID ++ K    L   +P E   +QE     
Sbjct: 3552 PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAA 3610

Query: 741  DFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHA 798
            D  + ++ +  K R    D ++ +  +FH  I   +Q L   E+ + + + P +   E  
Sbjct: 3611 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVE 3667

Query: 799  KYKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRW 851
            K K  + E ++    + + Q +  TL   GEE+I +S  TD  I    +Q+KL  +   W
Sbjct: 3668 KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIW 3727

Query: 852  QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLE 910
            + +   + +R+ +L +   +  +F  D    ++ +++  +      +PG +  + K++ E
Sbjct: 3728 ENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQE 3787

Query: 911  QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRAL 968
              + + EE+   Q  L  +   G  ++ +      E DK  ++  + + N  W  +++A 
Sbjct: 3788 AAETIREEIDGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAW 3843

Query: 969  PEKQGEIEAQIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQ 1025
             ++  ++E  ++   Q +  L+   D  +     L  +SPI   LE   Q  +E    ++
Sbjct: 3844 KDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LK 3899

Query: 1026 ETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD 1085
            + +     +Q ++E +  + + L K K   +  K  ++D   E K +   L+E       
Sbjct: 3900 QFKSEAYQQQIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER------ 3952

Query: 1086 LAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWL 1145
                                  ++ ++    KLE   +L+    AL  F  A  EL  WL
Sbjct: 3953 ----------------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWL 3981

Query: 1146 SLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEA 1205
            +  + ++  Q+ + GD + I   + K      D+   +  +E +  A  +L   ++ +EA
Sbjct: 3982 THTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEA 4041

Query: 1206 RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESW 1265
              +  +++E +  +W  V E  + R+QQL+  L+ +  +    E+ +Q L      L + 
Sbjct: 4042 SNL-QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLAS 4100

Query: 1266 KEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENI 1325
            K      +  ++++    ++       +           ++L          +     N+
Sbjct: 4101 KPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNL 4160

Query: 1326 NASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLE 1385
               W S+  +++ER+  LEE   L  +F   L+ F+ WLT+AE T NV   A+R   +L+
Sbjct: 4161 KEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILD 4217

Query: 1386 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 1445
                V   + + +    E+ +H +    LD+     L+      D VL++  L ++  +W
Sbjct: 4218 T---VLFQIDEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRW 4273

Query: 1446 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQND 1505
             ++ ++ +     L+ +  + K+ H +  +L+ WL+  +  L  +  I  D   ++ Q  
Sbjct: 4274 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4333

Query: 1506 VHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRK 1565
             H+ F++ L  K  V  +T  T                    R L  +    +    L  
Sbjct: 4334 QHKEFQKSLGAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDD 4374

Query: 1566 QAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GD 1624
               E+  +W+ +   S + Q K++E L    +  +A   L   L + E      QPV GD
Sbjct: 4375 MLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD 4434

Query: 1625 LLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWK 1684
              ID + + ++  KA + E+     +V  +   AR+L       S +    +++L+TRW+
Sbjct: 4435 --IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWE 4492

Query: 1685 LL-------QVAVEDRVRQLHEAH 1701
             +       Q  +E  +RQ  E H
Sbjct: 4493 TVCALSISKQTRLEAALRQAEEFH 4516



 Score =  216 bits (549), Expect = 3e-55
 Identities = 302/1617 (18%), Positives = 647/1617 (40%), Gaps = 189/1617 (11%)

Query: 97   QRVLSQIDVAQKKLQDVSMKFRLFQK---PAN-----FEQRLQESKMILDEV-KMHLPAL 147
            + +L++ +   ++L+ +S+  + F +   P N      E+RL   + I  +  K+     
Sbjct: 3071 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3130

Query: 148  ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTAL 207
            + K++E +++    NH  +L++++S  +S   +  +  + +VQ K           +   
Sbjct: 3131 QHKALEDDII----NHNKHLHQAVSIGQSLKVLSSREDKDMVQSK-----------LDFS 3175

Query: 208  KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 267
            ++ Y E+  K   R + L++ L  ++   ++   L  WL     +L+K S  +     L 
Sbjct: 3176 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3235

Query: 268  SEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 326
             + +  +  Q++I  +K ++      G E LK   G +  +++DKL  + + +  +T  +
Sbjct: 3236 KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3295

Query: 327  EEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDVL---KRLKA 381
             +    L +  +         + +  W+  ++ + L  E++  K ++        K LK 
Sbjct: 3296 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3355

Query: 382  ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI--KTGKASIPL 439
            E  + +  +DS  + ++ L+       R+ +E  ++E N R+  +S  I  K  +    +
Sbjct: 3356 EAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3415

Query: 440  KELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED---NEGTVKE 485
               +QF+              +KL+   +  ++Q     +    K    +   ++  + +
Sbjct: 3416 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDD 3475

Query: 486  LLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQA 545
            L++ G  +    ++E K + +K K   +   ++ +  + S+R  +         Q+    
Sbjct: 3476 LVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETY 3534

Query: 546  DDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEELNAVRRQAEG 594
            ++L   L + +  ++ LP P            + R+++E+  E +   +++N    Q   
Sbjct: 3535 EELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 3594

Query: 595  LSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISY 654
            LS  G   +++   +     + +I+      ++   A    + + T      D  LE   
Sbjct: 3595 LSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDKIDQILESLE 3650

Query: 655  VPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDII 714
                 L +   +S  + ++++ ++     + D E L    E+LK   + +   SG  D  
Sbjct: 3651 RIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 3710

Query: 715  HSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI 774
             S K              +Q+ L Q+ F WE ++ + ++R+ +    +E   +F  D   
Sbjct: 3711 ISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMS 3757

Query: 775  FNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGE 826
                + + + F+R  + P        +  E A+    ++E  DG+ +   +V  L   G 
Sbjct: 3758 LIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDIVINL---GS 3811

Query: 827  EIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWL 886
            E+I    + D  I+++ +  LN  W  + K   DR  +LEE      ++Q  L     W+
Sbjct: 3812 ELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWV 3871

Query: 887  EEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPE 945
            + A   +AS+       + +K+++E++K    E   +Q  +++LN     +L       E
Sbjct: 3872 DIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT---E 3928

Query: 946  EQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 1003
            E DK  +++ L +  L W  +   +  +Q ++E  +  LGQ +  L++L       L WL
Sbjct: 3929 ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-------LAWL 3981

Query: 1004 SPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQHLYKEKPAT 1055
            +     L    Q    G     E E+A        V A Q  VE +   G  L +     
Sbjct: 3982 THTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGE 4039

Query: 1056 QP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKET 1113
            +   ++ KLE L+  W+ V                                      ++T
Sbjct: 4040 EASNLQNKLEVLNQRWQNV-------------------------------------LEKT 4062

Query: 1114 AISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK 1173
               K ++  +L         F+    +L  WL+  ++ + + + + G  E   E +    
Sbjct: 4063 EQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM 4118

Query: 1174 ATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 1233
                  E +    + L+   Q +  +   + A T I   I  ++ +W+ V+  L  R+ +
Sbjct: 4119 EVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVETKLNERKTK 4177

Query: 1234 LNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 1293
            L E L  + ++  + ++    L QA   L         +D +  +I E K  A ++   +
Sbjct: 4178 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHR 4237

Query: 1294 TNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQF 1353
              +   +     L       D   +  +  ++ + W  + +R+ ER  +L++  +  +QF
Sbjct: 4238 EQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQF 4297

Query: 1354 PLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHN 1413
                 K + WL E+E + +       +  +  D   +K  + Q ++ Q  + A   VY  
Sbjct: 4298 HEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDT 4351

Query: 1414 LDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSL 1473
             +   + +      +DD + L   L  +  KW  +  KS+  ++ LE +     +   +L
Sbjct: 4352 TNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4411

Query: 1474 QELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLT 1533
            Q L+ WL   + +L+   P+ GD   V    D H+AF++EL  +                
Sbjct: 4412 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT--------------- 4456

Query: 1534 EQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLE 1593
                  ++ L +  REL   E +++ +  ++ Q +E++T WE +   S   Q +++  L 
Sbjct: 4457 ----SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALR 4510

Query: 1594 RLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVKALRGEI 1644
            + +E       L   L +AE        + D       LID  ++ ++K++  R E+
Sbjct: 4511 QAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAEL 4567



 Score =  212 bits (540), Expect = 3e-54
 Identities = 302/1584 (19%), Positives = 628/1584 (39%), Gaps = 175/1584 (11%)

Query: 102  QIDVAQKKLQDVSMKFRLFQKPAN-----FEQRLQESKMI----------LDEVKMHLPA 146
            ++ + Q KL+ +  +++   K +       EQ LQ ++ +          LD+V++ L +
Sbjct: 3273 EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLS 3332

Query: 147  LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTA 206
             ET+ ++ E           L K     K+ ++ + +    +++       + L++ V  
Sbjct: 3333 YETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE 3392

Query: 207  LKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNL 266
                Y  +   +T++ ++++  +  S++  +  +    W+  T+ +L     +       
Sbjct: 3393 DNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT 3452

Query: 267  DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSR 325
             +++   K    EI + K  +  + + G  + T   ++E   ++ KL  +  N+  +   
Sbjct: 3453 SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQI 3512

Query: 326  AEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD-------ESEKKKPQQKED-VLK 377
              E    L   Q  +  F +  + +  W+ +  +++        E E  + QQ+E   L+
Sbjct: 3513 NSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLR 3572

Query: 378  RLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASI 437
             L AE      K++ T  Q   L    G      ++ +    +  ++ I   +K    ++
Sbjct: 3573 ELIAEHKPHIDKMNKTGPQLLELSPGEGFS----IQEKYVAADTLYSQIKEDVKKRAVAL 3628

Query: 438  P--LKELEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTV------- 483
               + +  QF+  I ++LE LE  +++      ++ + E   + ++E+   +V       
Sbjct: 3629 DEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQP 3688

Query: 484  --KELLQRGDNLQQRITDERKREEIKIKQQLLQTK---HNALKDLRSQRRKKALEISHQW 538
              + L QRG+ +  R     K    K  Q  L         +  L  +R  K L++    
Sbjct: 3689 LYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 3748

Query: 539  YQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKKEELNAVRRQAE---G 594
             ++      L+  + D +  +  L +P  D   +K+     +  +EE++ ++ + +    
Sbjct: 3749 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVIN 3808

Query: 595  LSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISY 654
            L  +  A   EP +  + K   E+ S +    +    +I  + EE M    +        
Sbjct: 3809 LGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL-EEAMQAAVQ-------- 3859

Query: 655  VPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDII 714
                Y   +  V   +      L +      D E + +Q E LK  K    Q    ++ +
Sbjct: 3860 ----YQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERL 3915

Query: 715  HSKKTAALQSATPV-ERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 773
            + +    L+  T   ++  +Q+ L +L   W+ + +   +RQ + + ++    +F + + 
Sbjct: 3916 NHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 3975

Query: 774  IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQ 830
                WLT  E  L + Q P   +    +  L +   LQ+ +   Q+ V  +N  G ++I+
Sbjct: 3976 ELLAWLTHTEGLLSE-QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIE 4034

Query: 831  QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 890
             S+  +AS LQ KL  LN RWQ V ++   RK++L+        F  ++ +   WL + +
Sbjct: 4035 SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTE 4094

Query: 891  N--IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQ- 947
               +AS PL  G  +  KE+L     +      ++   K L + G  +L   P S E   
Sbjct: 4095 RHLLASKPLG-GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4153

Query: 948  DKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIR 1007
            D+  N LK+   +W  V   L E++ ++E  +    +    L+D        + WL+   
Sbjct: 4154 DQDINNLKE---KWESVETKLNERKTKLEEALNLAMEFHNSLQDF-------INWLTQAE 4203

Query: 1008 NQLEIYNQPN---QEGPFDVQETEI---AVQAKQPDVEEILSKGQHL--YKEKPATQPVK 1059
              L + ++P+       F + E ++    V + +  + E+   G HL  + +K     +K
Sbjct: 4204 QTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK 4263

Query: 1060 RKLEDLSSEW-KAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKL 1118
              L  + S W K V RL++  R                                      
Sbjct: 4264 NLLISVQSRWEKVVQRLVERGR-------------------------------------- 4285

Query: 1119 EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD 1178
                SL         F+ AW++L +WL   ++ + S+  +  D + I   + + K   + 
Sbjct: 4286 ----SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKS 4341

Query: 1179 LEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEML 1238
            L  +    +      ++LK KTS  +    + D +  ++++WD +      R+ +L E L
Sbjct: 4342 LGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEAL 4401

Query: 1239 KDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDV 1298
              S Q+ +A +     L +   +L   +     +D +   I   K   K+L +  ++V  
Sbjct: 4402 LFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQA 4461

Query: 1299 ANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLE 1358
                A +L+   S DD+  V +  + ++  W ++      ++  LE   R  ++F   + 
Sbjct: 4462 LKRSARELIEG-SRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVH 4520

Query: 1359 KFLAWLTEAETTAN---VLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLD 1415
              L WL EAE T     VL D     R L D    KE MK+ ++ + E+   T +   + 
Sbjct: 4521 ALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQH--KEFMKKLEEKRAELNKATTMGDTV- 4577

Query: 1416 ENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE 1475
                    ++   D    ++  +  +  ++ E+   +   +  L ++          L+ 
Sbjct: 4578 -------LAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEA 4630

Query: 1476 LLVWLQLKDDELSRQAP--IGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVR---- 1529
            LL WLQ  +  L+ +    I  +   V+     H+ F  E+  K+P +    +T +    
Sbjct: 4631 LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAA 4690

Query: 1530 --------IFLTEQPLEGLEK-----LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 1576
                    I + ++   G ++     LY    +   E +   V  L+ K        W++
Sbjct: 4691 DPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSK--------WQQ 4742

Query: 1577 LNLHSADWQRKIDETLERLQELQE 1600
            + L + + +RK+++ L+RL+EL+E
Sbjct: 4743 VWLLALERRRKLNDALDRLEELRE 4766



 Score =  206 bits (525), Expect = 2e-52
 Identities = 321/1772 (18%), Positives = 710/1772 (40%), Gaps = 195/1772 (11%)

Query: 22   KLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEI 81
            K L Q +    E   S     E++T   K+      +     Q  +E   I   L S   
Sbjct: 2625 KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAY 2684

Query: 82   SLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF--------------RLFQKPANFE 127
            S + +      +++ Q +  Q+D+A++  QD+ ++                + Q+ +   
Sbjct: 2685 SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS 2744

Query: 128  QRLQESKMILD---------------------EVKMHLPALETKSVEQEVVQSQLNHCVN 166
            Q++ E    L+                     E    L ++     + E +Q Q      
Sbjct: 2745 QQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKA 2804

Query: 167  LYKSLSEVKSEVEMVIKTGRQIVQKKQTE-NPKELDERVTALKLHYNELGAKVTERKQQL 225
              K L  + +  +   KT + ++  ++T  +   +   + AL    N+L  +   R++Q+
Sbjct: 2805 FLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 2864

Query: 226  EKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQK-EIEKQK 284
            E  +K   +   ++   +  L   +     +  V      ++ ++   K  QK EIE  +
Sbjct: 2865 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 2924

Query: 285  VHLKSITEVGEALKTVLGKKETL--VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 342
               + +  +G+ L     K  +   +E  L  +N+ W  +  +  +    L E   H   
Sbjct: 2925 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 2984

Query: 343  FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 402
            F   ++ +  W++  + L+  + +K P  +  V+K    E   ++  +D  R     ++ 
Sbjct: 2985 FQDALESLLSWMVDTEELV--ANQKPPSAEFKVVKAQIQEQKLLQRLLDD-RKSTVEVIK 3041

Query: 403  NRGDHCRKLVEP--------QISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 454
              G+      EP        Q+S L+ R+ A+ ++ +T       ++LE  +   Q+  E
Sbjct: 3042 REGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN-----RQLEGISVVAQQFHE 3096

Query: 455  PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK--REEIKIKQQL 512
             LE   +    +++   N +        ++E + +   L+  I +  K   + + I Q L
Sbjct: 3097 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL 3156

Query: 513  LQTKHNALKDLRSQRRKKALEISHQWY-QYKRQADDLLKCLDDIEKKLASLPEPRDERKI 571
                    KD+   +    L+ S  WY + + ++    + L           E  DE ++
Sbjct: 3157 KVLSSREDKDMVQSK----LDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGE--DEVEL 3210

Query: 572  KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 631
                 E+  K  +L+      EGL +  + + V    I L K  + ++        LN  
Sbjct: 3211 MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK--QNVDQAL-----LNGL 3263

Query: 632  QI--HTVREETMMVMTEDMPLEISYVPSTYL-TEITHVSQALLEVEQLLNA--PDLCA-- 684
            ++   T  +E +++  +   ++  Y   T L T++    +  L++ + L++   +LC   
Sbjct: 3264 ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWL 3323

Query: 685  -------KDFE-DLFKQEESL------KNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 730
                     +E  + K EE+       K +K   + +   +D ++   +A L+      R
Sbjct: 3324 DKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAR 3383

Query: 731  VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK-- 788
              L++ +++ + ++  V+     +    D ++ + ++F         W+TE E+ L    
Sbjct: 3384 EGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLG 3443

Query: 789  -TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSL 847
              ++ ++   A+ +   K     I + + ++  L  +G +I+   S+ +   +++KL  +
Sbjct: 3444 DIRLEQDQTSAQLQ-VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKV 3502

Query: 848  NLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIAS-IPLEPGKEQQLK 906
               +  +C+  S+R  +LE  ++++++F     E   WL E  +I S +P    + + L+
Sbjct: 3503 LKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLR 3562

Query: 907  EKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSR 966
            ++ E+ + L E +   +  + ++N+TG  +L    +SP E   ++ K    +  + ++  
Sbjct: 3563 QQQEEHRQLRELIAEHKPHIDKMNKTGPQLL---ELSPGEGFSIQEKYVAADTLYSQIKE 3619

Query: 967  ALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL-SPIRNQLEIYNQPNQEGPFDVQ 1025
             + ++   ++  I    Q   K++ + E L  ++  L  P     E+  +  +E   + +
Sbjct: 3620 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEV--EKIKEQISENK 3677

Query: 1026 ETEIAVQAKQPDVEEILSKGQHLYKEKPAT------QPVKRKLEDLSSEWKAVNRLLQEL 1079
               + ++  QP  E +  +G+ +      T      + V+ KL+ +   W+ ++ L++E 
Sbjct: 3678 NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEER 3737

Query: 1080 RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 1139
             AK                                          +L+V  LA+  + W 
Sbjct: 3738 EAK------------------------------------------LLDVMELAE--KFW- 3752

Query: 1140 ELTDWLSLLDQVIKSQRVMVGDLED--INEMIIK-QKATMQDLEQRRPQLEELITAAQNL 1196
               D +SL+   IK  +  + DLED  I+  ++K Q+   + + +    L+E +    NL
Sbjct: 3753 --CDHMSLI-VTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 3809

Query: 1197 KNK---TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 1253
             ++      +  + I+   I+ + + WD + +  ++R  +L E ++ + Q+ +  +    
Sbjct: 3810 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 3869

Query: 1254 VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 1313
             +  A  KL S       ++ ++++I E KQ   +  Q Q  ++  N  A  LL+  + +
Sbjct: 3870 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 3929

Query: 1314 -DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN 1372
             D   V      +   W S+ +R+  R+  LE     L QF   L++ LAWLT  E    
Sbjct: 3930 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL-- 3987

Query: 1373 VLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAV 1432
                 + ++ +  D K ++  + +   LQ ++ AH      +++    ++ S  G ++A 
Sbjct: 3988 ----LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG-EEAS 4042

Query: 1433 LLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP 1492
             LQ +L+ +N +W  + +K+   +  L+ +  Q K  H  +++L  WL   +  L    P
Sbjct: 4043 NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKP 4102

Query: 1493 IGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP 1552
            +GG     ++Q +VH       + KE    S ++  +  L   P      + Q+   L  
Sbjct: 4103 LGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNL-- 4160

Query: 1553 EERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQA 1612
                                +WE +     + + K++E L    E   +  +    L QA
Sbjct: 4161 ------------------KEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQA 4202

Query: 1613 E-VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPY 1671
            E  +  + +P   L++D++   +++ K    E+   +E +  ++     L     +    
Sbjct: 4203 EQTLNVASRP--SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4260

Query: 1672 NL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 1702
             + + L  + +RW+ +   + +R R L +A +
Sbjct: 4261 LIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4292



 Score =  198 bits (503), Expect = 6e-50
 Identities = 343/1820 (18%), Positives = 730/1820 (40%), Gaps = 205/1820 (11%)

Query: 24   LEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE---AQKIQSDLTSHE 80
            ++Q+I  + + +  L  + + L+ +D +L++ +A       M Q+   AQK++ ++   +
Sbjct: 2319 IDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEK 2378

Query: 81   ISL---------------EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN 125
              +               EE  K    ++    + S  DV QK    V            
Sbjct: 2379 KQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2438

Query: 126  FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTG 185
            F+Q  ++ +  LD  K         S + +V++S +    +  K+L+      E  I  G
Sbjct: 2439 FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEG 2498

Query: 186  RQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEW 245
              ++ K Q      L  ++  +K +++    +V ER+ +L++ L+ + K ++++  L  W
Sbjct: 2499 ENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2558

Query: 246  LAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKK 304
            +      L + +  ++  P+  ++ +A  K+ QKE+++    ++ +     +L +V    
Sbjct: 2559 IDKCQNNLEEIKFCLD--PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2616

Query: 305  ETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDES 364
            + +V D+   L      VT +       L    +  + F +      + +  A   LD  
Sbjct: 2617 KEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH 2676

Query: 365  EKKKPQQKED----VLKRLKAELNDIRPKVDSTRDQAANLMANRGD-HCRKLVEPQISEL 419
            +    Q   +    +L+  +  L  ++ +VD  +  A +L+    D      V  Q+  +
Sbjct: 2677 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETI 2736

Query: 420  NHRFAAISHRI--KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNE 477
                + +S ++  K       L+ +  F + I+++         +  ++     + +  +
Sbjct: 2737 AQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQ 2796

Query: 478  DNEGTVKELLQR-------GDNLQQR-----ITDERKREEIKIKQQL--LQTKHNALKDL 523
              + T+K  L++        DN  +       T+E   + + IK+ L  L  + N L D 
Sbjct: 2797 KQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLD- 2855

Query: 524  RSQRRKKALEIS----HQWYQYKRQADDLLKCLDDIEK-------KLASLPEPRDERKI- 571
            R+Q R++ +E +     ++Y   ++   LL+  ++ E+       +  ++ +  +  K+ 
Sbjct: 2856 RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVF 2915

Query: 572  -KEIDRELQKKKEELNAVRRQAEGLSEDGA----AMAVEPTQIQLSKRWREIESKFAQ-F 625
             KE    LQ K++++N +    +GL +  A       +E     ++ RW+ +  K AQ  
Sbjct: 2916 QKEEIEPLQGKQQDVNWL---GQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRA 2972

Query: 626  RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 685
             +L  A +H  R                     +   +  +   +++ E+L+      + 
Sbjct: 2973 AQLQEALLHCGR---------------------FQDALESLLSWMVDTEELVANQKPPSA 3011

Query: 686  DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 745
            +F+ +  Q +  K ++  L      +++I  +      +A P ++VK+ + LS LD +WE
Sbjct: 3012 EFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWE 3071

Query: 746  KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL- 804
             +    + R  + +      ++FH  ++  N+WLT  E+ L   + P   + +K +  + 
Sbjct: 3072 ALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE-PIGTQASKLEEQIA 3130

Query: 805  --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 862
              K L+D I      +    + G+ +   SS+ D  ++Q KL    + + E+ ++   R 
Sbjct: 3131 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3190

Query: 863  KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIPLEPGKEQQLKEKLEQVKLLVEELPL 921
            + L++       F  D  E + WL E  D ++ + ++    + L ++  ++++L E++ L
Sbjct: 3191 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3250

Query: 922  R-----QGILKQL----NETGGPVLV------SAPISPEEQDKLENKLKQTNLQWIKVSR 966
            R     Q +L  L      TG  VL+      +     ++  KL   + +T  Q ++++R
Sbjct: 3251 RKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3310

Query: 967  ALPEKQGEI--------------EAQI-------------KDLGQLEKKLEDLEEQLNHL 999
             L     E+              E Q+             K+L +  K  + L + LN +
Sbjct: 3311 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEV 3370

Query: 1000 ---LLWLSP--IRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPA 1054
               LL L P   R  LE     + E    V +T   +  K  +++  + + Q   +   A
Sbjct: 3371 SSALLELVPWRAREGLEKMVAEDNERYRLVSDT---ITQKVEEIDAAILRSQQFDQAADA 3427

Query: 1055 -------TQPVKRKLEDLSSEWKAVNRLLQELRA------KQPDLAPGL--------TTI 1093
                   T+     L D+  E    +  LQ  +       +  D+   L        T  
Sbjct: 3428 ELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3487

Query: 1094 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW---TELTDWLSLLDQ 1150
                 Q++      V+     I ++     L LE  A +  N+ W    EL  WL+    
Sbjct: 3488 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE-RAQSLVNQFWETYEELWPWLTETQS 3546

Query: 1151 VIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIIT 1210
            +I        + E + +   + +   + + + +P ++++      L   +  +     I 
Sbjct: 3547 IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS--IQ 3604

Query: 1211 DRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP- 1269
            ++       + +++E ++ R   L+E +  STQ+    ++ +Q+L      +E  ++ P 
Sbjct: 3605 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQF---HDKIDQILESLERIVERLRQPPS 3661

Query: 1270 --YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL-RDYSADDTRKVHMITENIN 1326
                V+ I+++I+E K ++ D+ + Q   +       +++ R    D       + + ++
Sbjct: 3662 ISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLD 3721

Query: 1327 AS---WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 1383
                 W +IH  V EREA L +   L ++F  D    +  + + +     L+D      +
Sbjct: 3722 QMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSV 3781

Query: 1384 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 1443
            ++  +   E ++  +++ G ++   D+  NL       L +  G  D  ++++ +D +N 
Sbjct: 3782 VKQQQEAAETIR--EEIDG-LQEELDIVINLGSE----LIAACGEPDKPIVKKSIDELNS 3834

Query: 1444 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 1503
             W  L K   +    LE +     +    LQ +  W+ +   +L+  +PIG D   V++Q
Sbjct: 3835 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 3894

Query: 1504 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 1563
             +  + FK E                    +Q +E +E+L  +   L  +   ++    +
Sbjct: 3895 IEELKQFKSE------------------AYQQQIE-MERLNHQAELLLKKVTEESDKHTV 3935

Query: 1564 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 1623
            +    E+   W+ L     + Q K++  L  L + Q A DEL   L   E +    +PVG
Sbjct: 3936 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 3995

Query: 1624 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTR 1682
                 +++  L K   L+ ++   +  V  VN     L          NL + LE LN R
Sbjct: 3996 G-DPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4054

Query: 1683 WKLLQVAVEDRVRQLHEAHR 1702
            W+ +    E R +QL  A R
Sbjct: 4055 WQNVLEKTEQRKQQLDGALR 4074



 Score =  191 bits (486), Expect = 6e-48
 Identities = 304/1643 (18%), Positives = 676/1643 (41%), Gaps = 168/1643 (10%)

Query: 36   KSLHLIQESLTFIDKQLAAYIADKVDA---AQMPQEAQKIQSDLTSHEISLEEMKKH-NQ 91
            ++L   +E++    K+L A +A   +A    +M    ++   DL   +  LE + K  N+
Sbjct: 2793 ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK 2852

Query: 92   GKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKS 151
              + AQ    Q++   K+L++             F  +L+E  ++L + + H  +     
Sbjct: 2853 LLDRAQAREEQVEGTIKRLEE-------------FYSKLKEFSILLQKAEEHEESQGPVG 2899

Query: 152  VEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTALKL 209
            +E E +  QLN      K  +  ++ + + V   G+ ++Q   ++ + + L+  +  +  
Sbjct: 2900 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 2959

Query: 210  HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 269
             +  L  KV +R  QL++ L    + +  +  L  W+  T+  +  +         + ++
Sbjct: 2960 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQ 3019

Query: 270  VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEE 328
            +   K  Q+ ++ +K  ++ I   GE + T     + + +  +LSLL+S W A+ ++AE 
Sbjct: 3020 IQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAET 3079

Query: 329  WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELNDI 386
                L       + F + ++ + +W+   +  L   E    Q    E+ + + KA  +DI
Sbjct: 3080 RNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDI 3139

Query: 387  RPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 441
                          Q+  ++++R D  + +V+ ++      F+ + + I+  + S    E
Sbjct: 3140 INHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSRSE 3191

Query: 442  LEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRITD 499
            L Q      K+    E E+   +N   +  +K   +D   EG  K+        + R+  
Sbjct: 3192 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRVLQ 3245

Query: 500  ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL 559
            E   + +  KQ + Q   N L+ L+     + L I  +    K +  D+ K   D+ K L
Sbjct: 3246 E---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3302

Query: 560  ASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWRE 617
                +    R++     EL     K E+  +  + + L  + A+ A +    +L K  + 
Sbjct: 3303 EQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEAKN 3359

Query: 618  IESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 673
             ++       ++ A +  V    RE    ++ ED       V  T   ++  +  A+L  
Sbjct: 3360 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAILRS 3418

Query: 674  EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV-- 731
            +Q   A D       +  K+  SL +I+    Q+S ++ +  +     L+    ++ +  
Sbjct: 3419 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3478

Query: 732  ---KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ--------- 777
               K+  A S+ + Q   +K++K+ K+       + E++ +      + NQ         
Sbjct: 3479 SGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELW 3538

Query: 778  -WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK 834
             WLTE +  + +   P  E     + +   ++L++ I + +  +  +N TG ++++ S  
Sbjct: 3539 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3598

Query: 835  TDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADNIA 893
               SI QEK  + +  + ++ + +  R   L+E  +  ++F   +++ +  LE   + + 
Sbjct: 3599 EGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 3657

Query: 894  SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDKLE 951
              P    + +++KE++ + K +  ++   Q + + L + G  ++  +  + ++     ++
Sbjct: 3658 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 3717

Query: 952  NKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIRNQ 1009
            +KL Q    W  +   + E+    EA++ D+ +L +K        +H  L++ +   ++ 
Sbjct: 3718 DKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQDF 3768

Query: 1010 LEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVKRK 1061
            +     P  +     Q+ E A      +   Q +++ +++ G  L     +P    VK+ 
Sbjct: 3769 IRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS 3828

Query: 1062 LEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMP 1121
            +++L+S W ++N+  ++                                    I KLE  
Sbjct: 3829 IDELNSAWDSLNKAWKD-----------------------------------RIDKLEEA 3853

Query: 1122 SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 1181
                  + A   +      + DW+ +    + S   +  DLE + + I + K    +  Q
Sbjct: 3854 ------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 3907

Query: 1182 RRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDS 1241
            ++ ++E L   A+ L  K + +  +  + D +  ++  WD ++E + NR+ +L   L   
Sbjct: 3908 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 3967

Query: 1242 TQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVAND 1301
             Q+  A +E    L      L   K       AI+ ++ +   L  D+   Q+ V+  N 
Sbjct: 3968 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4027

Query: 1302 LALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFL 1361
                L+   + ++   +    E +N  W+++ ++  +R+  L+   R  + F  ++E   
Sbjct: 4028 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQ 4087

Query: 1362 AWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKI 1421
             WLT+ E      +     + L    +  KE +    ++    EA  + Y +L +  Q++
Sbjct: 4088 QWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQM 4141

Query: 1422 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 1481
            L     S +   + + ++N+  KW  +  K    ++ LE + +     H SLQ+ + WL 
Sbjct: 4142 LARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4200

Query: 1482 LKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQPLE 1538
              +  L+  +        V  Q D H+ F  E+ +    I+   +T   ++ F  +Q + 
Sbjct: 4201 QAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4260

Query: 1539 GLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQRKI 1588
             ++ L      +  + R + V + L          RK+A++ +  W KL     +W  + 
Sbjct: 4261 LIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLEES 4311

Query: 1589 DETLERLQELQEATDELDLKLRQ 1611
            +++L+   E+    D++  +L Q
Sbjct: 4312 EKSLDSELEIANDPDKIKTQLAQ 4334



 Score =  176 bits (447), Expect = 2e-43
 Identities = 370/1827 (20%), Positives = 735/1827 (40%), Gaps = 273/1827 (14%)

Query: 21   QKLLEQSIQSAQETEKSL-HLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSH 79
            QK ++ S Q+  E  K+  + ++E+   + ++  A I  K++ A++  E   ++++ +  
Sbjct: 1278 QKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKK 1337

Query: 80   EISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDE 139
            E+   +       KE  ++V +   + + K +  ++   L     + E+   + K ++++
Sbjct: 1338 EL---DKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQ 1394

Query: 140  VKMHLPALETKSV---EQEVVQSQLNHCV---------NLYKSLSEVKSEVEMVIKTGRQ 187
               H    + KS    E EV  + L   V         NL +   +VK++ E +I   + 
Sbjct: 1395 NGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQA 1454

Query: 188  IVQKKQT--------------ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS- 232
            ++   Q+              E  ++L + +  LK+HY E     +E+K +L   L+   
Sbjct: 1455 VIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHY-ETALAESEKKMKLTHSLQEEL 1513

Query: 233  RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 292
             K   +      WL  ++ EL    A     + L +++   K+  +++   K  L+ IT 
Sbjct: 1514 EKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITI 1573

Query: 293  VG----EALKTVL----GKKETL-----VEDKLSLLNSNWIAVTSRAEEWLN----LLLE 335
             G    EA K+      GK +T      V+ KL      + ++ S+     N    L+ +
Sbjct: 1574 SGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK 1633

Query: 336  YQKHMETFDQNVDHITKWIIQADTLLDES---EKKKPQQKEDVLKRLKAELNDIRPKVDS 392
            YQ + +     +  +      A   L E    + K  Q++ +  K L+ +++  +  V+ 
Sbjct: 1634 YQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEK 1693

Query: 393  TRDQAANLMANRGD--HCRKLVEPQISELNHRFAAISHRIK------------------- 431
             +  A  L+  RG     +  ++  + ++  R+  +S  +                    
Sbjct: 1694 LKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDG 1753

Query: 432  -------TGKASIPLKELEQF---NSDIQKLLEP---LEAEI---QQGVNLKEEDFNKDM 475
                    G     LKE  Q    ++ +Q ++     LE +I   Q  +N   E   K M
Sbjct: 1754 LDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFM 1813

Query: 476  NEDNEGTVKELLQRGDNLQQRITD-ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEI 534
               +  T   L  +  +L  R ++   K +E   K + L+TK    ++L S++ +  LE 
Sbjct: 1814 ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL-SEKLQTFLET 1872

Query: 535  SHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQ--A 592
              Q           L  +D   K +  L +   E   + +  E +K  E L+++ ++  +
Sbjct: 1873 KTQ----------ALTEVDVPGKDVTELSQYMQESTSEFL--EHKKHLEVLHSLLKEISS 1920

Query: 593  EGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEI 652
             GL  D  A+ +E T   LSK+++E+E               T++E+   V +    L+ 
Sbjct: 1921 HGLPSD-KALVLEKTN-NLSKKFKEMED--------------TIKEKKEAVTSCQEQLDA 1964

Query: 653  SYVPSTYLTE-ITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEE--SLKNIKDSLQQSSG 709
              V    L   I   ++ +  V+    A DL  K  ED  K +E  SLK  +     +SG
Sbjct: 1965 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDL-GKSLEDTKKLQEKWSLKTPEIQKVNNSG 2023

Query: 710  RIDIIH--------SKKTAALQS----------ATPVER-------VKLQEALSQLDFQW 744
             I + +        +K  AA++S          AT  E          +++ ++ +   +
Sbjct: 2024 -ISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2082

Query: 745  EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK---TQIPENWEHAKYK 801
            E +  + KD+    +  + K ++   +     QWL +  +   K   T  P + E  K +
Sbjct: 2083 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2142

Query: 802  -WYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKT-DASILQEKLGSLNLRWQEVCKQLS 859
                K  +  + Q    V+ L     E+++++  T +A   ++ L  ++ +WQE+ +   
Sbjct: 2143 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2202

Query: 860  DRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASI--PLEPGKEQQLKEKLEQVKLLVE 917
            DR+++LEE  N L++FQ    +   WL E + + S+  PL       L  + +QV++L++
Sbjct: 2203 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQ 2261

Query: 918  ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 977
            E   R+   +QL   G  +L      P  +  ++ +L     +W  ++  L ++   I+ 
Sbjct: 2262 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2321

Query: 978  QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPD 1037
             I    Q +  L  L ++L+ L   LS   + L +   P+       Q+ E A + KQ  
Sbjct: 2322 AIVKSTQYQSLLRSLSDKLSDLDNKLS---SSLAVSTHPDAMN----QQLETAQKMKQEI 2374

Query: 1038 VEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGA 1095
             +E   +   Q L ++  A    +    +LS + + + +  +++  K  +    L +  A
Sbjct: 2375 QQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACA 2434

Query: 1096 SPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 1155
            S  Q                                  F +   +   WL    +     
Sbjct: 2435 SSHQ----------------------------------FQQMSRDFQAWLDTKKEEQNKS 2460

Query: 1156 RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIER 1215
              +   L+ +  +I   K   + L  +    E+ I   +NL  KT   E +  +  ++  
Sbjct: 2461 HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSE-KAALQLQLNT 2519

Query: 1216 IQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 1275
            I+  WD   + ++ R  +L E L+ + ++ E  E     + + +  LE  K   + +D  
Sbjct: 2520 IKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIK---FCLDPA 2576

Query: 1276 --QKKITETKQLAKDLRQWQTNVDVANDLALKLL------RDYSADDTR----KVHMITE 1323
              +  I + K L K++ Q    V++ N+ A  LL      ++   D+ +    KV M+TE
Sbjct: 2577 EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE 2636

Query: 1324 NINAS---WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 1380
             +++      ++ ++  E +   +E+ R LQ     L+               + D+   
Sbjct: 2637 QLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD---------------IHDSLGS 2681

Query: 1381 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDN 1440
            +     +K +  L  Q + LQ  ++   D+   L ++        +G+ D +L   +++ 
Sbjct: 2682 QAY--SNKYLTMLQTQQKSLQA-LKHQVDLAKRLAQDLVVEASDSKGTSDVLL---QVET 2735

Query: 1441 MNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAV 1500
            +  + S L ++     S LE           +++E+       DDEL   AP+G D   +
Sbjct: 2736 IAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETL 2795

Query: 1501 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 1560
            QKQ +  +AF ++L+       +  +T ++ L                    EE + ++ 
Sbjct: 2796 QKQKETIKAFLKKLEALMASNDNANKTCKMMLA------------------TEETSPDLV 2837

Query: 1561 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 1620
              +++  E ++ +  KL   +   + +++ T++RL+E      E  + L++AE  + S  
Sbjct: 2838 G-IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQG 2896

Query: 1621 PVGDLLIDSLQDHLEKVKAL-RGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST---- 1675
            PVG +  +++   L   K   + EI PL+     VN L + L    IQ +  + ST    
Sbjct: 2897 PVG-METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL----IQSAAKSTSTQGLE 2951

Query: 1676 --LEDLNTRWKLLQVAVEDRVRQLHEA 1700
              L+D+N RWK L   V  R  QL EA
Sbjct: 2952 HDLDDVNARWKTLNKKVAQRAAQLQEA 2978



 Score =  161 bits (407), Expect = 8e-39
 Identities = 282/1447 (19%), Positives = 579/1447 (40%), Gaps = 202/1447 (13%)

Query: 33   ETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS-HEISLEEMKKHNQ 91
            ETEK L  + +     D+  A     K    ++ +    I   + S H+I     ++  Q
Sbjct: 3434 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ 3493

Query: 92   G-KEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN-FEQRLQESKMILDEVKMHLPALET 149
              K+   +VL   D   +   +  ++    Q   N F +  +E    L E +  +  L  
Sbjct: 3494 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3553

Query: 150  KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 209
             ++E E ++ Q      L + ++E K  ++ + KTG Q+++    E    + E+  A   
Sbjct: 3554 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG-FSIQEKYVAADT 3612

Query: 210  HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 269
             Y+++   V +R   L++ +  S +   +++ + E L      L +  ++      +  +
Sbjct: 3613 LYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 3672

Query: 270  VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-----LVEDKLSLLNSNWIAVTS 324
            ++  K    ++EK +   +++ + GE +    G  +       V+DKL  +   W  + +
Sbjct: 3673 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 3732

Query: 325  RAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP-------QQKEDVLK 377
              EE    LL+  +  E F    DH++  +   DT     + + P       +Q+++  +
Sbjct: 3733 LVEEREAKLLDVMELAEKFW--CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 3790

Query: 378  RLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT--GKA 435
             ++ E++ ++ ++D   +  + L+A  G+  + +V+  I ELN  + +++   K    K 
Sbjct: 3791 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 3850

Query: 436  SIPLKELEQFNSDIQKL--------------------LEPLEAEIQQGVNLKEEDFNKDM 475
               ++   Q+   +Q +                    LE ++ +I++    K E + + +
Sbjct: 3851 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 3910

Query: 476  NEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEIS 535
                   ++ L  + + L +++T+E  +  ++     L+   ++L++    R+ K     
Sbjct: 3911 E------MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGAL 3964

Query: 536  HQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEID--------RELQKKKEELNA 587
                Q++   D+LL  L   E  L+       + K  EI+         ++   +  + A
Sbjct: 3965 LALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEA 4024

Query: 588  VRRQAEGLSEDGAAMAVEPTQIQL---SKRWREIESKFAQFRR-----LNFAQ-IHTVRE 638
            V +    L E  A       Q +L   ++RW+ +  K  Q ++     L  A+  H   E
Sbjct: 4025 VNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIE 4084

Query: 639  ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 698
            +    +T+     ++  P   L E           EQL    ++CA  FE    +EE+ K
Sbjct: 4085 DLQQWLTDTERHLLASKPLGGLPETAK--------EQLNVHMEVCAA-FE---AKEETYK 4132

Query: 699  NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 758
            ++    QQ   R       K+A            + + ++ L  +WE V     +R+ + 
Sbjct: 4133 SLMQKGQQMLARCP-----KSA---------ETNIDQDINNLKEKWESVETKLNERKTKL 4178

Query: 759  DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPEN------WEHAKYKWYLKELQDGIG 812
            + ++     FH  ++ F  WLT+AEQ L     P        ++  ++K +  E+     
Sbjct: 4179 EEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS--- 4235

Query: 813  QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 872
             R+ ++  L+ TG  +   S K D  +++  L S+  RW++V ++L +R + L++ +   
Sbjct: 4236 HREQIIE-LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRA 4294

Query: 873  SEFQRDLNEFVLWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNE 931
             +F    ++ + WLEE++      LE   +  ++K +L Q K   + L  +  +    N 
Sbjct: 4295 KQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4354

Query: 932  TGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLED 991
            TG  +     ++ ++  KL++ L +   +W  +     E+Q ++E  +   GQ    L+ 
Sbjct: 4355 TGRSLKEKTSLA-DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQA 4413

Query: 992  LEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE 1051
            L +       WL  +  QL   +QP   G  D+    I       D  +   K   L K 
Sbjct: 4414 LID-------WLYRVEPQLA-EDQP-VHGDIDLVMNLI-------DNHKAFQK--ELGKR 4455

Query: 1052 KPATQPVKRKLEDL------SSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 1105
              + Q +KR   +L       S W  V   +QEL  +                +TV  ++
Sbjct: 4456 TSSVQALKRSARELIEGSRDDSSWVKVQ--MQELSTRW---------------ETVCALS 4498

Query: 1106 QPVVTK-ETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 1164
                T+ E A+ + E             +F+     L +WL+  +Q ++   V+  D + 
Sbjct: 4499 ISKQTRLEAALRQAE-------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4545

Query: 1165 INEMIIKQKATMQDLEQRRPQLEELITAAQNL------KNKTSNQEARTIITDRIERIQN 1218
            +  +I + K  M+ LE++R +L +  T    +       + T+ +   TII  R E +  
Sbjct: 4546 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 4605

Query: 1219 QWDEVQEHLQN------RRQQLNEMLKDSTQWLEAK-------------EEAEQVLGQAR 1259
               + Q+ L +       +Q+L E L    QW E               EE + ++ + +
Sbjct: 4606 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 4665

Query: 1260 AKLESWKEGPYTVDAIQKKITET-KQLAKDLRQWQTNVDV-----ANDLALKLLRDYSAD 1313
              +E        VD    K+T+T K+ A D    Q+++ V     A          Y + 
Sbjct: 4666 TFMEEMTRKQPDVD----KVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 4721

Query: 1314 DTRKVHMITENIN---ASWRSIHKRVSEREAALEETHRLLQQ------FPLDL--EKFLA 1362
               ++      +N   + W+ +     ER   L +    L++      F  D+  +K++ 
Sbjct: 4722 SQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMR 4781

Query: 1363 WLTEAET 1369
            W+   ++
Sbjct: 4782 WMNHKKS 4788



 Score =  159 bits (401), Expect = 4e-38
 Identities = 321/1720 (18%), Positives = 690/1720 (40%), Gaps = 221/1720 (12%)

Query: 30   SAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKH 89
            S++E       + E+L  I   LA +  DK+   +  +  +++++   S+ +   E  K 
Sbjct: 1151 SSEEISTKKEQLSEALQTIQLFLAKH-GDKMTDEERNELEKQVKTLQESYNLLFSESLKQ 1209

Query: 90   NQGKEAAQRVLSQIDVAQKKLQDVSMKFR-LFQKPANFEQRL---QESKMILDEVKMHLP 145
             Q  + +  V  +  +  ++ Q+   K + +       E RL   QE+ MI D   + L 
Sbjct: 1210 LQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGT-VELK 1268

Query: 146  ALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVT 205
              ++K   QE +Q  +       ++L+EV    E  +K   +   K   E+   +++++ 
Sbjct: 1269 KYQSK---QEELQKDMQGSA---QALAEVVKNTENFLKENGE---KLSQEDKALIEQKLN 1319

Query: 206  ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 265
              K+   +L  K  + K++L+K +  + K        TE +AA       ++ +E +   
Sbjct: 1320 EAKIKCEQLNLKAEQSKKELDKVVTTAIKEE------TEKVAAVKQLEESKTKIENL--- 1370

Query: 266  LDSEVAWGKATQKEIEKQKV-HLKSITEVGEALKTVLGKKETLVEDKLS--LLNSNWIAV 322
                + W     K+ E+    H + I + G   +   GK     ED+++  LL ++    
Sbjct: 1371 ----LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQ 1426

Query: 323  TSRAEEWLNLLLEYQKHMETFDQNVDHITKWII---QADTLLD-ESEKKKPQQKEDVLKR 378
                +E  NL  +YQK     ++ +      II    A  LL+ + +   P++KE + K 
Sbjct: 1427 VGTTQE--NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN 1484

Query: 379  LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP 438
            +K    +++   ++   ++   M          ++ ++ + +  +    H ++  +    
Sbjct: 1485 MK----ELKVHYETALAESEKKMK-----LTHSLQEELEKFDADYTEFEHWLQQSEQE-- 1533

Query: 439  LKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRIT 498
            L+ LE    DI  L+  L+         +++ F++D+   ++G ++ +   G+ + +   
Sbjct: 1534 LENLEAGADDINGLMTKLK---------RQKSFSEDVIS-HKGDLRYITISGNRVLEAAK 1583

Query: 499  DERKREEIKIK--------QQLLQTKHNALKDLRSQRR---KKALEISHQWYQYKRQADD 547
               KR+  K+         Q+ L    +  + L S+         ++  ++  Y+  +  
Sbjct: 1584 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1643

Query: 548  LLKCLDDIEKKLAS-LPEP---------RDERKIKEIDRELQKKKEELNAVRRQAEGLSE 597
            LL  L   E   +  L EP         R   + K +  ++  ++  +  +++ AE L +
Sbjct: 1644 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 1703

Query: 598  DGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPS 657
              A  ++ P +  + K   +I  ++    +     ++   E+  + +T  + ++      
Sbjct: 1704 --ARGSLLPAKNDIQKTLDDIVGRYEDLSK----SVNERNEKLQITLTRSLSVQDGL--D 1755

Query: 658  TYLTEITHVSQALLEVEQL-LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 716
              L  + +V  +L E  Q+ LN+  L     +D+  +   L+      Q S   I+ ++ 
Sbjct: 1756 EMLDWMGNVESSLKEQGQVPLNSTAL-----QDIISKNIMLEQDIAGRQSS---INAMNE 1807

Query: 717  KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFN 776
            K    +++  P     LQ  +  L  ++ + +  +K+   + +    K   F    +   
Sbjct: 1808 KVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQ 1867

Query: 777  QWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD 836
             +L    Q L +  +P   +  +   Y++E      + +  +  L++  +EI      +D
Sbjct: 1868 TFLETKTQALTEVDVPGK-DVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSD 1926

Query: 837  ASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIP 896
             +++ EK  +L+ +++E+   + ++K+ +   +  L  FQ  +     W++E      I 
Sbjct: 1927 KALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIV 1986

Query: 897  LEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV--LVSAPISPEEQDKL---- 950
                  + L + LE  K L E+  L+   ++++N +G  +  L+SA  +P +        
Sbjct: 1987 QPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSG 2046

Query: 951  ------ENKLKQTNLQWI-KVSRALPEKQGEIEAQIKDLGQLEK-----------KLEDL 992
                  E     T   W  K   ++ +   +I    +DLG L K           KL+  
Sbjct: 2047 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2106

Query: 993  EEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP----------DVEEIL 1042
            +E+ + ++ WL  +      + Q     P D +  +  V+  +            V+E+ 
Sbjct: 2107 QEESSAMMQWLQKMNKTATKWQQT--PAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELK 2164

Query: 1043 SKGQHLYKEKPATQPV---KRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 1099
             K   L +E P T      K+ L ++ S+W+ +N+L  + + K  + +  LT       Q
Sbjct: 2165 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQ 2224

Query: 1100 TVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMV 1159
                + Q +V KE  +S L                          LS+   ++ +QR  V
Sbjct: 2225 ----LKQWLVEKELMVSVLGP------------------------LSIDPNMLNTQRQQV 2256

Query: 1160 GDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEA-RTIITDRIERIQN 1218
                         +  +Q+   R+PQ E+L  A Q + ++     + R I+ +++  +  
Sbjct: 2257 -------------QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQ 2303

Query: 1219 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 1278
            +WD +   L +R   +++ +  STQ+          L     KL S        DA+ ++
Sbjct: 2304 KWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQ 2363

Query: 1279 ITETKQLAKDLRQWQTNVDVA----NDLALKLLRDY-SADDTRKVHMITENINASWRSIH 1333
            +   +++ ++++Q +  + VA     DL+  +  +Y  A+ +R++  I ++     +   
Sbjct: 2364 LETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAE 2423

Query: 1334 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1393
              V   ++A   +H+  QQ   D   F AWL   +   N     + K  +LE       L
Sbjct: 2424 NHVQHLQSACASSHQ-FQQMSRD---FQAWLDTKKEEQNKSHPISAKLDVLE------SL 2473

Query: 1394 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1453
            +K  +D    + A + +Y       + +L   +GS+ A  LQ +L+ +   W    K+  
Sbjct: 2474 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA-LQLQLNTIKTNWDTFNKQVK 2532

Query: 1454 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR----QAPIGGD-----FPAVQKQN 1504
               + L+ S ++  +    ++ L  W+    + L        P  G+       ++QK+ 
Sbjct: 2533 ERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEM 2592

Query: 1505 DVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERA-QNVTRLL 1563
            D H      L      ++S  E  +  +T++    ++K+     +L  ++   +N+T+  
Sbjct: 2593 DQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 2652

Query: 1564 RKQAEEVNTEWEKLNLHSADWQRKIDETL-------ERLQELQEATDELDLKLRQAEVIK 1616
             K+ +EV+ E  K  L  A  Q  I ++L       + L  LQ     L     Q ++ K
Sbjct: 2653 -KEFQEVSKE-SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAK 2710

Query: 1617 GSWQPVGDLLIDS-----LQDHLEKVKALRGEIAPLKENV 1651
               Q   DL++++       D L +V+ +  E + L + V
Sbjct: 2711 RLAQ---DLVVEASDSKGTSDVLLQVETIAQEHSTLSQQV 2747



 Score =  149 bits (376), Expect = 3e-35
 Identities = 324/1747 (18%), Positives = 698/1747 (39%), Gaps = 230/1747 (13%)

Query: 50   KQLAAYIA-DKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-EAAQRVLSQIDVAQ 107
            K L+  IA D  +  +  +E + +Q  ++S ++++E++KK  +   +A   +L   +  Q
Sbjct: 1657 KHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 1716

Query: 108  KKLQDVSMKFRLFQKPAN-----FEQRLQESKMI---LDEVKMHLPALETKSVEQEVV-- 157
            K L D+  ++    K  N      +  L  S  +   LDE+   +  +E+   EQ  V  
Sbjct: 1717 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 1776

Query: 158  -----QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYN 212
                 Q  ++  + L + ++  +S +  + +  ++ ++         L  ++  L   ++
Sbjct: 1777 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFS 1836

Query: 213  ELG-------AKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 265
            E         AK+ E K ++E    LS K++  +   T+  A T++++  +   E +   
Sbjct: 1837 EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ--ALTEVDVPGKDVTE-LSQY 1893

Query: 266  LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSR 325
            +    +     +K +E     LK I+  G      L   + LV +K + L+  +  +   
Sbjct: 1894 MQESTSEFLEHKKHLEVLHSLLKEISSHG------LPSDKALVLEKTNNLSKKFKEMEDT 1947

Query: 326  AEEWLNLLLEYQKHMETFDQNVDHITKW---------IIQ----ADTLLDESEKKKPQQK 372
             +E    +   Q+ ++ F   V  +  W         I+Q    A+ L    E  K  Q+
Sbjct: 1948 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2007

Query: 373  EDVLKRLKAE--------LNDIRPKV-------------------DSTRDQAANLMANRG 405
            +  LK  + +        L ++   V                   + T        AN+G
Sbjct: 2008 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2067

Query: 406  ---------------DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDI 449
                           +    L++ +I+ELN + + +    +   A +  L+++ +  +  
Sbjct: 2068 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2127

Query: 450  QKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIK 509
            Q+   P + E  +    + + F  ++ + N   V+EL  +   L +   D  +    K  
Sbjct: 2128 QQTPAPTDTEAVKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQM 2186

Query: 510  QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDE 568
               + +K   L  L   R++K  E S+   Q++     L + L + E  ++ L P   D 
Sbjct: 2187 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP 2246

Query: 569  RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRL 628
              +    +++Q   +E    + Q E L+  G  +   P +          +       + 
Sbjct: 2247 NMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGE----------DPSLRGIVKE 2296

Query: 629  NFAQIHTVREETMMVMTEDMP--LEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAK 685
              A + T + +++     D    ++ + V ST Y + +  +S  L +++  L++    + 
Sbjct: 2297 QLAAV-TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST 2355

Query: 686  DFEDLFKQEESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQ 743
              + + +Q E+ + +K  +QQ   +I +  +  +  +AL        VK +   ++L  Q
Sbjct: 2356 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQ 2407

Query: 744  WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 803
             E + K +KD + + +  V+  +        F Q   + + +L   +  +N  H      
Sbjct: 2408 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHP-ISAK 2466

Query: 804  LKELQDGIGQRQTVVRTLNAT----------GEEIIQQSSKTDASILQEKLGSLNLRWQE 853
            L  L+  I   +   +TL A           GE ++ ++  ++ + LQ +L ++   W  
Sbjct: 2467 LDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDT 2526

Query: 854  VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLE 910
              KQ+ +R+ +L+E      +++  +     W+++  +N+  I   L+P + +    KL 
Sbjct: 2527 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKL- 2585

Query: 911  QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPE 970
              K L +E+    G+++ LN T   +L    I  E     ENK                 
Sbjct: 2586 --KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK----------------- 2625

Query: 971  KQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA 1030
                          L +K++ + EQL+     L  +  + + + + ++E      + ++ 
Sbjct: 2626 -------------SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES-----KRQLQ 2667

Query: 1031 VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 1090
               +Q D+ + L    +  K     Q  ++ L+ L  +     RL Q+L  +  D     
Sbjct: 2668 CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD----- 2722

Query: 1091 TTIGASPTQTVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLL 1148
                +  T  V L  + +  + + +S+   E  S L  ++  +  F     E+    +  
Sbjct: 2723 ----SKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEF 2778

Query: 1149 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 1208
            D  + S   +  D E +     KQK T++   ++   LE L+ +  N  NKT      T 
Sbjct: 2779 DDELDSMAPVGRDAETLQ----KQKETIKAFLKK---LEALMASNDNA-NKTCKMMLATE 2830

Query: 1209 ITDR--------IERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 1260
             T          +E +  Q +++ +  Q R +Q+   +K   ++    +E   +L +A  
Sbjct: 2831 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 2890

Query: 1261 KLESWKEGPYTVDAIQKKITETKQLAKD-LRQWQTNVDVANDLALKLLRDYS-ADDTRKV 1318
              ES        + I +++   K   K+ +   Q      N L   L++  + +  T+ +
Sbjct: 2891 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 2950

Query: 1319 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT 1378
                +++NA W++++K+V++R A L+E      +F   LE  L+W+ + E        A 
Sbjct: 2951 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----AN 3005

Query: 1379 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 1438
            +K    E  K VK  +++ + LQ  ++        +    +KI  + E +D   +L ++L
Sbjct: 3006 QKPPSAE-FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQL 3063

Query: 1439 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFP 1498
              ++ +W  L  K+      LE  S   ++ H +L+ L  WL   +  L    PIG    
Sbjct: 3064 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3123

Query: 1499 AVQKQNDVHRAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPE 1553
             +++Q   H+A + ++      +   +S  +++++  + +  + ++    + +   +  +
Sbjct: 3124 KLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3183

Query: 1554 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLK 1608
            E++ + + LL++         E   +   +W  ++ + L +L     +T+ L     +L+
Sbjct: 3184 EKSHSRSELLQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR 3242

Query: 1609 LRQAEVIKGSWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHV 1654
            + Q +++    Q V   L++ L              QD LE +KA   +I  L  +V+  
Sbjct: 3243 VLQEDILLRK-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3301

Query: 1655 NDLARQL 1661
             + A QL
Sbjct: 3302 LEQALQL 3308



 Score = 92.4 bits (228), Expect = 5e-18
 Identities = 321/1840 (17%), Positives = 702/1840 (38%), Gaps = 349/1840 (18%)

Query: 20   RQKLLEQSI--QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLT 77
            R+ LL+ S+  Q+  E E ++  +Q+ L ++D+                    ++Q D T
Sbjct: 259  RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEM-------------------QVQLDRT 299

Query: 78   SHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMIL 137
                 L  ++ H +  +   R + +                       FE  L+E+K  +
Sbjct: 300  EWGSDLPSVESHLENHKNVHRAIEE-----------------------FESSLKEAK--I 334

Query: 138  DEVKMHLPALETKSVEQEVVQSQ----LNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 193
             E++M  P   T + +   ++SQ    LN   N  + L  + + V         + +K++
Sbjct: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394

Query: 194  TENPKELDERVTAL---KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATD 250
             E   +  ER T +   K ++ EL  ++ ++++ ++   +++ ++  E +          
Sbjct: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH---------- 444

Query: 251  MELTKRSAVEGMPSNLDSEVAW----GKATQKEIEKQKVHLKSITEVGEALKTVLGKKET 306
                 R  +E   + + ++ +W     +  ++ I++   + +   +  EA   +   K+ 
Sbjct: 445  ---PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDA 501

Query: 307  LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK 366
             ++ K S   S+ I       +  +L+ E  +  E   Q    I   + +A T++    +
Sbjct: 502  -IQRKYSCDRSSSI------HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII----Q 550

Query: 367  KKPQQKEDVLKR---LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRF 423
             KP+  +  LK    +KA  +  + ++   +D    L  N      K++ P  +E     
Sbjct: 551  LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPS 610

Query: 424  AAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN----LKEEDFNKDMNEDN 479
               +      +A      +EQ   ++  L       ++  V+    + E D    +   N
Sbjct: 611  VCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID---RIRASN 667

Query: 480  EGTVKELL-----QRGDNLQQRITD--ERKREE--------IKIKQQLLQTKHNALKDLR 524
              ++K +L     Q   NLQ R  D  E  +E          ++++++   K    + L+
Sbjct: 668  VASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLK 727

Query: 525  SQRRKKALEISHQWY--QYKRQADDLLKCLDDIEKKLASLPEPRDE--------RKIKEI 574
            S  R++  E  +  Y  + +     L  C D + +++ + P  RD+         + +++
Sbjct: 728  SAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT-PLERDDLHESVFRITEQEKL 786

Query: 575  DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIH 634
             +EL++ K++L  +  + E      AA +  PT                           
Sbjct: 787  KKELERLKDDLGTITNKCEEFFSQAAASSSVPT--------------------------- 819

Query: 635  TVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLNAPDLCAKDFEDLF 691
             +R E  +V+ ++M  ++  + STY+ ++  V+  L      E L+   +    + E + 
Sbjct: 820  -LRSELNVVL-QNMN-QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVI 876

Query: 692  KQEESLKNIKDSLQQSSGRID----IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKV 747
              + +++N+  +L+Q    +D    + H+ +    ++    + +        LDF W K 
Sbjct: 877  ADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKE 936

Query: 748  NKMYKDRQGRFDRSVEKWRRFHYDIKI---------------------FNQWLTEAEQFL 786
                     + D+ VE+W+  H  I                        + W+ + E   
Sbjct: 937  ---------KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 987

Query: 787  RKTQI--PENWEHA-----KYKWYLKEL---QDGIGQRQTVVRTLNATGEEIIQQSSKTD 836
            RK Q   PEN +       + K  + E+   Q  + + Q      +AT ++   Q+    
Sbjct: 988  RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYR 1047

Query: 837  ASILQEKLGSLNLRWQE-----VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 891
            A +  ++   +  R  +     + ++  D + R      +++++ +   + +  LEE   
Sbjct: 1048 AMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEE-- 1105

Query: 892  IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLE 951
                  E   E++ KE +E+ K L + +      LK   + G P      IS EE    +
Sbjct: 1106 ------EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1159

Query: 952  NKLKQTNLQWIKV------SRALPEKQGEIEAQIKDLGQ--------------------- 984
             +L +  LQ I++       +   E++ E+E Q+K L +                     
Sbjct: 1160 EQLSEA-LQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGD 1218

Query: 985  --LEKKL-----EDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPD 1037
              +E+K+     ++ +E+L  +   L+   N+L  + +    G   V+  +   Q+KQ +
Sbjct: 1219 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKY--QSKQEE 1276

Query: 1038 VEEILSKGQHLYKE--KPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIG 1094
            +++ +        E  K     +K   E LS E KA + + L E + K   L        
Sbjct: 1277 LQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSK 1336

Query: 1095 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD----- 1149
                + VT   +    K  A+ +LE  S   +E             L DWLS +D     
Sbjct: 1337 KELDKVVTTAIKEETEKVAAVKQLE-ESKTKIE------------NLLDWLSNVDKDSER 1383

Query: 1150 ------QVIKSQ---------RVMVGDLEDINEMIIKQKA------TMQDLEQR----RP 1184
                  QVI+           +  +G+ +++N  +++         T ++L Q+    + 
Sbjct: 1384 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1443

Query: 1185 QLEELITAAQNLKNKTSN------QEARTIITDRIERIQNQWDEVQEHLQN------RRQ 1232
            Q E++I+  Q +   T +      ++ + +  +  E++Q    E++ H +       ++ 
Sbjct: 1444 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1503

Query: 1233 QLNEMLKDSTQWLEAK-EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQ 1291
            +L   L++  +  +A   E E  L Q+  +LE+ + G   ++ +  K+   K  ++D+  
Sbjct: 1504 KLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 1563

Query: 1292 WQTN---VDVANDLALKLLRDYSADDT---------RKVHMITENINASWRSIHKRVSER 1339
             + +   + ++ +  L+  +  S  D          R+V    ++    +RS++ + +  
Sbjct: 1564 HKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVL 1623

Query: 1340 EAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD 1399
               L++     Q +       LA L   E TA+        E +  D K ++  +++ + 
Sbjct: 1624 GNNLKDLVDKYQHYEDASCGLLAGLQACEATAS----KHLSEPIAVDPKNLQRQLEETKA 1679

Query: 1400 LQGEIEAHTDVYHNLDENSQKILRS----LEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 1455
            LQG+I +       L + ++ +L +    L   +D   +Q+ LD++  ++ +L K     
Sbjct: 1680 LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND---IQKTLDDIVGRYEDLSKSVNER 1736

Query: 1456 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ-------------- 1501
               L+ +  +   +   L E+L W+   +  L  Q  +  +  A+Q              
Sbjct: 1737 NEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIA 1796

Query: 1502 -KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 1560
             +Q+ ++   ++  K  E    ST  +++  + +      E  ++    L   E  +   
Sbjct: 1797 GRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKV 1856

Query: 1561 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 1620
             L    +E++ T  E       +      +  E  Q +QE+T E     +  EV+    +
Sbjct: 1857 ELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLK 1916

Query: 1621 PVGD--------LLIDSLQDHLEKVKALRGEIAPLKENVS 1652
             +          L+++   +  +K K +   I   KE V+
Sbjct: 1917 EISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVT 1956



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 216/1059 (20%), Positives = 424/1059 (40%), Gaps = 156/1059 (14%)

Query: 692  KQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMY 751
            K ++ L+ +KD L   + + +   S+  AA  S+ P  R +L   L  ++ Q   ++  Y
Sbjct: 785  KLKKELERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMN-QVYSMSSTY 841

Query: 752  KDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQD 809
             D+    +  ++  +     +K++   L E E  +      EN      +W   + E + 
Sbjct: 842  IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 901

Query: 810  GIGQRQTVVRTLNATGEEIIQQSSKTDASI--LQEKLGSLNLRWQEVCKQLSDRKKRLEE 867
                 +  ++   A  +E+ +   + D      +EK   L  RWQ V  Q+ +R + LE 
Sbjct: 902  VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 961

Query: 868  QKNILSEFQRDLNEFVLWLEEADNIASIPLE--PGKEQQLKEKLEQVKLLVEELPLRQGI 925
                L  ++   +    W+++ +       E  P   + L  +L Q K+LV E+ ++Q  
Sbjct: 962  IGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1021

Query: 926  LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 985
            + +  +       SA +   E   +  +    + Q   V R     Q   +  I++   L
Sbjct: 1022 MDECQKYAEQY--SATVKDYELQTMTYRAMVDSQQKSPVKRR--RMQSSADLIIQEFMDL 1077

Query: 986  EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKG 1045
              +   L   +   + +      +LE      +E   + ++ E   +AK+  +++ +S  
Sbjct: 1078 RTRYTALVTLMTQYIKFAGDSLKRLE-----EEEKSLEEEKKEHVEKAKE--LQKWVSNI 1130

Query: 1046 QHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL 1103
                K  EK    P  +  + +SSE         E+  K+  L+  L TI          
Sbjct: 1131 SKTLKDAEKAGKPPFSK--QKISSE---------EISTKKEQLSEALQTI---------- 1169

Query: 1104 VTQPVVTKETAISKLEMPSSLMLEVPALAD-FNRAWTELTDWLSLLDQVIKSQRVMVGDL 1162
              Q  + K       E  + L  +V  L + +N  ++E       L Q+ +SQ    GD+
Sbjct: 1170 --QLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES------LKQLQESQTS--GDV 1219

Query: 1163 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE--RIQNQW 1220
            + + E I+ ++   Q+ +++   + +L+T  +N      +QEA  I    +E  + Q++ 
Sbjct: 1220 K-VEEKIVAER--QQEYKEKLQGICDLLTQTEN--RLIGHQEAFMIGDGTVELKKYQSKQ 1274

Query: 1221 DEVQEHLQNRRQQLNEMLKDSTQWL---------EAKEEAEQVLGQARAKLE-------- 1263
            +E+Q+ +Q   Q L E++K++  +L         E K   EQ L +A+ K E        
Sbjct: 1275 EELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQ 1334

Query: 1264 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 1323
            S KE    V    K+ TE     K L + +T ++   D    + +D     T+   +I +
Sbjct: 1335 SKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQ 1394

Query: 1324 NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQ-DATRKER 1382
            N        H +  + ++A+ E                    E E   N+L+ D   +  
Sbjct: 1395 N------GTHFQEGDGKSAIGE--------------------EDEVNGNLLETDVDGQVG 1428

Query: 1383 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1442
              +++     L +Q+Q ++ + E        +    Q ++ + + +   VLL+++   ++
Sbjct: 1429 TTQEN-----LNQQYQKVKAQHE-------KIISQHQAVIIATQSAQ--VLLEKQGQYLS 1474

Query: 1443 FKWSE-LRKKSLNIRSHLE---ASSDQWKRLHLSLQELLV-----------WLQLKDDEL 1487
             +  E L+K    ++ H E   A S++  +L  SLQE L            WLQ  + EL
Sbjct: 1475 PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL 1534

Query: 1488 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLT-EQPLEGLEKLYQ- 1545
                    D       N +    KR+    E VI    +   I ++  + LE  +   + 
Sbjct: 1535 ENLEAGADDI------NGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKR 1588

Query: 1546 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 1605
            +  ++      + V R L    +   + + K N+        + + +++ Q  ++A+  L
Sbjct: 1589 DGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLG----NNLKDLVDKYQHYEDASCGL 1644

Query: 1606 --DLKLRQAEVIKGSWQPVGDLLID--SLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 1661
               L+  +A   K   +P+    +D  +LQ  LE+ KAL+G+I+  +  V  +   A  L
Sbjct: 1645 LAGLQACEATASKHLSEPIA---VDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVL 1701

Query: 1662 TTLGIQLSPYN---LSTLEDLNTRWKLLQVAVEDRVRQL 1697
                  L P       TL+D+  R++ L  +V +R  +L
Sbjct: 1702 LDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL 1740


>gi|42717999 dystrobrevin alpha isoform 2 [Homo sapiens]
          Length = 686

 Score =  212 bits (540), Expect = 3e-54
 Identities = 171/590 (28%), Positives = 279/590 (47%), Gaps = 72/590 (12%)

Query: 1756 DLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQ--PMDILQIINCL 1813
            DL+ +R S YRTA KLR +QK   L L+ +    +AL ++ L   D    +++ ++   L
Sbjct: 26   DLDRIRLSTYRTACKLRFVQKKCNLHLVDIWNVIEALRENALNNLDPNTELNVSRLEAVL 85

Query: 1814 TTIYDRLEQEH--NNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLE 1871
            +TI+ +L +     + ++V   + + LN+LL  +D    G+I V + K  + +LC   + 
Sbjct: 86   STIFYQLNKRMPTTHQIHVEQSISLLLNFLLAAFDPEGHGKISVFAVKMALATLCGGKIM 145

Query: 1872 DKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANN 1931
            DK RY+F  ++ S+G     R    L + +++P  + E  SFG +  E S RSCF   + 
Sbjct: 146  DKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGYT--EQSARSCF---SQ 200

Query: 1932 KPEIEAALFLDWMRLEP--QSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK 1989
            + ++    FLD +  +P  Q +VWLP+LHR+A  E   H  +C+ C    ++GFRYR  +
Sbjct: 201  QKKVTLNGFLDTLMSDPPPQCLVWLPLLHRLANVENVFHPVECSYCHSESMMGFRYRCQQ 260

Query: 1990 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP 2049
              NY +CQ CF+ G     H   + M EY   T+     +     L          ++ P
Sbjct: 261  CHNYQLCQDCFWRGHAGGSHSNQHQMKEY---TSWKSPAKKLTNALSKSLSCAS--SREP 315

Query: 2050 RMGYLPVQTVLEGDNMETPVTL---INFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEM 2106
                 P       D  E P+ L   ++ WP     + +  L      S    + +R + +
Sbjct: 316  LHPMFP-------DQPEKPLNLAHIVDTWPPRPVTSMNDTLFSHSVPSSGSPFITR-SML 367

Query: 2107 ENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQP---RSPAQILISLESEERG 2163
            E+SN             +D+EH LI  Y   L  +S  SQP   RS   I  ++++ +  
Sbjct: 368  ESSN------------RLDEEHRLIARYAARLAAESSSSQPPQQRSAPDISFTIDANK-- 413

Query: 2164 ELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKL 2223
            +  +++A+LE +NR +  E  RL+ +HE +   P P   +  PT         L+AE +L
Sbjct: 414  QQRQLIAELENKNREILQEIQRLRLEHE-QASQPTPEKAQQNPT---------LLAELRL 463

Query: 2224 LRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSS 2283
            LRQ K  LE RM  L++  ++L  QL  L +LL+   A     G+  SSPS ++ R    
Sbjct: 464  LRQRKDELEQRMSALQESRRELMVQLEGLMKLLKTQGA-----GSPRSSPSHTISR---P 515

Query: 2284 QPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRN 2333
             PM +R   + ++ +         PQD+ TG   V   +  +F  S  RN
Sbjct: 516  IPMPIRSASACSTPT-------HTPQDSLTG---VGGDVQEAFAQSSRRN 555


>gi|42718005 dystrobrevin alpha isoform 1 [Homo sapiens]
          Length = 743

 Score =  206 bits (525), Expect = 2e-52
 Identities = 180/629 (28%), Positives = 291/629 (46%), Gaps = 93/629 (14%)

Query: 1756 DLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQ--PMDILQIINCL 1813
            DL+ +R S YRTA KLR +QK   L L+ +    +AL ++ L   D    +++ ++   L
Sbjct: 26   DLDRIRLSTYRTACKLRFVQKKCNLHLVDIWNVIEALRENALNNLDPNTELNVSRLEAVL 85

Query: 1814 TTIYDRLEQEH--NNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLE 1871
            +TI+ +L +     + ++V   + + LN+LL  +D    G+I V + K  + +LC   + 
Sbjct: 86   STIFYQLNKRMPTTHQIHVEQSISLLLNFLLAAFDPEGHGKISVFAVKMALATLCGGKIM 145

Query: 1872 DKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANN 1931
            DK RY+F  ++ S+G     R    L + +++P  + E  SFG +  E S RSCF   + 
Sbjct: 146  DKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGYT--EQSARSCF---SQ 200

Query: 1932 KPEIEAALFLDWMRLEP--QSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK 1989
            + ++    FLD +  +P  Q +VWLP+LHR+A  E   H  +C+ C    ++GFRYR  +
Sbjct: 201  QKKVTLNGFLDTLMSDPPPQCLVWLPLLHRLANVENVFHPVECSYCHSESMMGFRYRCQQ 260

Query: 1990 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAK-- 2047
              NY +CQ CF+ G     H   + M EY +        +  AK L N        A   
Sbjct: 261  CHNYQLCQDCFWRGHAGGSHSNQHQMKEYTS-------WKSPAKKLTNALSKSLSCASSR 313

Query: 2048 ---HPRMGYLPVQTVLEGDNMET----PVTLIN------FWPVDSAP---ASSPQLSHDD 2091
               HP     P + +     ++T    PVT +N        P   +P    SSP    + 
Sbjct: 314  EPLHPMFPDQPEKPLNLAHIVDTWPPRPVTSMNDTLFSHSVPSSGSPFITRSSPPKDSEV 373

Query: 2092 THSRI-----------------EHYASRLAEMENSNGSYLN-------DSISPNESIDDE 2127
              +++                  + A RLA+     G Y+N         +  +  +D+E
Sbjct: 374  EQNKLLARAAPAFLKGKGIQYSLNVADRLADEHVLIGLYVNMLRNNPSCMLESSNRLDEE 433

Query: 2128 HLLIQHYCQSLNQDSPLSQP---RSPAQILISLESEERGELERILADLEEENRNLQAEYD 2184
            H LI  Y   L  +S  SQP   RS   I  ++++ +  +  +++A+LE +NR +  E  
Sbjct: 434  HRLIARYAARLAAESSSSQPPQQRSAPDISFTIDANK--QQRQLIAELENKNREILQEIQ 491

Query: 2185 RLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQ 2244
            RL+ +HE +   P P   +  PT         L+AE +LLRQ K  LE RM  L++  ++
Sbjct: 492  RLRLEHE-QASQPTPEKAQQNPT---------LLAELRLLRQRKDELEQRMSALQESRRE 541

Query: 2245 LESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDL 2304
            L  QL  L +LL+   A     G+  SSPS ++ R     PM +R   + ++ +      
Sbjct: 542  LMVQLEGLMKLLKTQGA-----GSPRSSPSHTISR---PIPMPIRSASACSTPT------ 587

Query: 2305 LSPPQDTSTGLEEVMEQLNNSFPSSRGRN 2333
               PQD+ TG   V   +  +F  S  RN
Sbjct: 588  -HTPQDSLTG---VGGDVQEAFAQSSRRN 612


>gi|42717997 dystrobrevin alpha isoform 5 [Homo sapiens]
          Length = 513

 Score =  206 bits (525), Expect = 2e-52
 Identities = 152/523 (29%), Positives = 253/523 (48%), Gaps = 54/523 (10%)

Query: 1756 DLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQ--PMDILQIINCL 1813
            DL+ +R S YRTA KLR +QK   L L+ +    +AL ++ L   D    +++ ++   L
Sbjct: 26   DLDRIRLSTYRTACKLRFVQKKCNLHLVDIWNVIEALRENALNNLDPNTELNVSRLEAVL 85

Query: 1814 TTIYDRLEQEH--NNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLE 1871
            +TI+ +L +     + ++V   + + LN+LL  +D    G+I V + K  + +LC   + 
Sbjct: 86   STIFYQLNKRMPTTHQIHVEQSISLLLNFLLAAFDPEGHGKISVFAVKMALATLCGGKIM 145

Query: 1872 DKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANN 1931
            DK RY+F  ++ S+G     R    L + +++P  + E  SFG +  E S RSCF   + 
Sbjct: 146  DKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGYT--EQSARSCF---SQ 200

Query: 1932 KPEIEAALFLDWMRLEP--QSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK 1989
            + ++    FLD +  +P  Q +VWLP+LHR+A  E   H  +C+ C    ++GFRYR  +
Sbjct: 201  QKKVTLNGFLDTLMSDPPPQCLVWLPLLHRLANVENVFHPVECSYCHSESMMGFRYRCQQ 260

Query: 1990 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP 2049
              NY +CQ CF+ G     H   + M EY   T+     +     L          ++ P
Sbjct: 261  CHNYQLCQDCFWRGHAGGSHSNQHQMKEY---TSWKSPAKKLTNALSKSLSCAS--SREP 315

Query: 2050 RMGYLPVQTVLEGDNMETPVTL---INFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEM 2106
                 P       D  E P+ L   ++ WP     + +  L      S    + +R + +
Sbjct: 316  LHPMFP-------DQPEKPLNLAHIVDTWPPRPVTSMNDTLFSHSVPSSGSPFITR-SML 367

Query: 2107 ENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQP---RSPAQILISLESEERG 2163
            E+SN             +D+EH LI  Y   L  +S  SQP   RS   I  ++++ +  
Sbjct: 368  ESSN------------RLDEEHRLIARYAARLAAESSSSQPPQQRSAPDISFTIDANK-- 413

Query: 2164 ELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKL 2223
            +  +++A+LE +NR +  E  RL+ +HE +   P P   +  PT         L+AE +L
Sbjct: 414  QQRQLIAELENKNREILQEIQRLRLEHE-QASQPTPEKAQQNPT---------LLAELRL 463

Query: 2224 LRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVN 2266
            LRQ K  LE RM  L++  ++L  QL  L +LL++ + +  V+
Sbjct: 464  LRQRKDELEQRMSALQESRRELMVQLEGLMKLLKEEELKQGVS 506


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.366 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,496,812
Number of Sequences: 37866
Number of extensions: 3941388
Number of successful extensions: 26941
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 154
Number of HSP's successfully gapped in prelim test: 1024
Number of HSP's that attempted gapping in prelim test: 15166
Number of HSP's gapped (non-prelim): 7423
length of query: 2344
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2225
effective length of database: 13,741,464
effective search space: 30574757400
effective search space used: 30574757400
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.