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Search of human proteins with 149158729
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
(609 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 1236 0.0
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 1236 0.0
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 1236 0.0
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 609 e-174
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 607 e-174
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 607 e-174
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 515 e-146
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 471 e-133
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi... 465 e-131
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 464 e-130
gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo sapi... 421 e-118
gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo sapi... 239 5e-63
gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo sapi... 233 3e-61
gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo sapi... 233 5e-61
gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo sapi... 161 1e-39
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 102 1e-21
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 96 1e-19
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 96 1e-19
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 96 1e-19
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 93 6e-19
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 93 6e-19
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 82 1e-15
gi|239582765 ral guanine nucleotide dissociation stimulator-like... 82 2e-15
gi|239582763 ral guanine nucleotide dissociation stimulator-like... 82 2e-15
gi|24307909 ral guanine nucleotide dissociation stimulator isofo... 82 2e-15
gi|108796058 ral guanine nucleotide dissociation stimulator isof... 82 2e-15
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 80 7e-15
gi|93102367 ral guanine nucleotide dissociation stimulator-like ... 77 4e-14
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 70 6e-12
gi|117168263 RasGEF domain family, member 1A [Homo sapiens] 70 6e-12
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 1236 bits (3197), Expect = 0.0
Identities = 609/609 (100%), Positives = 609/609 (100%)
Query: 1 MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY 60
MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY
Sbjct: 1 MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY 60
Query: 61 QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID 120
QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID
Sbjct: 61 QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID 120
Query: 121 IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS 180
IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS
Sbjct: 121 IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS 180
Query: 181 FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF 240
FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF
Sbjct: 181 FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF 240
Query: 241 NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR 300
NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR
Sbjct: 241 NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR 300
Query: 301 FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL 360
FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL
Sbjct: 301 FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL 360
Query: 361 LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ 420
LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ
Sbjct: 361 LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ 420
Query: 421 ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM 480
ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM
Sbjct: 421 ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM 480
Query: 481 VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540
VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC
Sbjct: 481 VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540
Query: 541 KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV 600
KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV
Sbjct: 541 KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV 600
Query: 601 EDGVFDIHL 609
EDGVFDIHL
Sbjct: 601 EDGVFDIHL 609
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 1236 bits (3197), Expect = 0.0
Identities = 609/609 (100%), Positives = 609/609 (100%)
Query: 1 MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY 60
MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY
Sbjct: 1 MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY 60
Query: 61 QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID 120
QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID
Sbjct: 61 QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID 120
Query: 121 IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS 180
IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS
Sbjct: 121 IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS 180
Query: 181 FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF 240
FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF
Sbjct: 181 FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF 240
Query: 241 NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR 300
NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR
Sbjct: 241 NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR 300
Query: 301 FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL 360
FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL
Sbjct: 301 FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL 360
Query: 361 LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ 420
LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ
Sbjct: 361 LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ 420
Query: 421 ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM 480
ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM
Sbjct: 421 ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM 480
Query: 481 VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540
VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC
Sbjct: 481 VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540
Query: 541 KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV 600
KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV
Sbjct: 541 KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV 600
Query: 601 EDGVFDIHL 609
EDGVFDIHL
Sbjct: 601 EDGVFDIHL 609
>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 1236 bits (3197), Expect = 0.0
Identities = 609/609 (100%), Positives = 609/609 (100%)
Query: 1 MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY 60
MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY
Sbjct: 1 MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY 60
Query: 61 QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID 120
QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID
Sbjct: 61 QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID 120
Query: 121 IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS 180
IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS
Sbjct: 121 IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS 180
Query: 181 FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF 240
FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF
Sbjct: 181 FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF 240
Query: 241 NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR 300
NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR
Sbjct: 241 NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR 300
Query: 301 FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL 360
FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL
Sbjct: 301 FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL 360
Query: 361 LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ 420
LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ
Sbjct: 361 LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ 420
Query: 421 ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM 480
ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM
Sbjct: 421 ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM 480
Query: 481 VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540
VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC
Sbjct: 481 VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540
Query: 541 KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV 600
KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV
Sbjct: 541 KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV 600
Query: 601 EDGVFDIHL 609
EDGVFDIHL
Sbjct: 601 EDGVFDIHL 609
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 609 bits (1570), Expect = e-174
Identities = 310/588 (52%), Positives = 406/588 (69%), Gaps = 11/588 (1%)
Query: 3 GTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQ 62
G+ L K T++ELL CIE FDD+G++ + L R+ L+MH WY+ S++LA KLL +Y+
Sbjct: 2 GSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRN 61
Query: 63 SRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDID 122
+ ++ N ++K C+ +RYWI FPAEF+L+ L +E + + Q G +H SLIDI
Sbjct: 62 ATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDIS 121
Query: 123 SVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFV 182
S+P+Y W R+VTQR V KK K LLFDHLEP+ELAEHLT+LE++SF +I F DY S+V
Sbjct: 122 SIPSYDWMRRVTQRKKVS-KKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 180
Query: 183 THGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNT 242
HGC +NP LER I+LFN +S+WVQLM+LSKPT QRA VIT F++VA+KLLQL+NFNT
Sbjct: 181 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 240
Query: 243 LMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFP 302
LMAVVGGLSHSSISRLKETHSH+S E K W +TELV++ GNY NYR+ A C GF+ P
Sbjct: 241 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 300
Query: 303 ILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLS 362
ILGVHLKDL+A+ + PDW + ++N KM QL L EL + + ++ N DL++
Sbjct: 301 ILGVHLKDLIAVHVIFPDWTE--ENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLIN 358
Query: 363 LLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQAL 422
LLT+SLD Y TED++Y+LSL EPR+ SPTSPT+ P +P V EW PK D +
Sbjct: 359 LLTLSLDLYHTEDDIYKLSLVLEPRNSKSPTSPTT---PNKPVVPLEWALGVMPKPDPTV 415
Query: 423 VVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMVS 482
+ +HI K+VESVFRN+D D DG+ISQE+F+ I NFP+L +F LD++QDG IS++EM++
Sbjct: 416 INKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMA 475
Query: 483 YFLRSSSVLGGRM--GFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540
YFLR+ S L +M GF+HNFQE L+P C HC + GI KQG KC+ CG NCHKQC
Sbjct: 476 YFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQC 535
Query: 541 KDRLSVECRRRAQSVSL---EGSAPSPSPMHSHHHRAFSFSLPRPGRR 585
KD L + CRR A++ SL GS P + F F G R
Sbjct: 536 KDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHR 583
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 607 bits (1566), Expect = e-174
Identities = 312/589 (52%), Positives = 407/589 (69%), Gaps = 12/589 (2%)
Query: 3 GTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQ 62
G+ L K T++ELL CIE FDD+G++ + L R+ L+MH WY+ S++LA KLL +Y+
Sbjct: 2 GSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRN 61
Query: 63 SRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDID 122
+ ++ N ++K C+ +RYWI FPAEF+L+ L +E + + Q G +H SLIDI
Sbjct: 62 ATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDIS 121
Query: 123 SVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFV 182
S+P+Y W R+VTQR V KK K LLFDHLEP+ELAEHLT+LE++SF +I F DY S+V
Sbjct: 122 SIPSYDWMRRVTQRKKVS-KKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 180
Query: 183 THGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNT 242
HGC +NP LER I+LFN +S+WVQLM+LSKPT QRA VIT F++VA+KLLQL+NFNT
Sbjct: 181 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 240
Query: 243 LMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFP 302
LMAVVGGLSHSSISRLKETHSH+S E K W +TELV++ GNY NYR+ A C GF+ P
Sbjct: 241 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 300
Query: 303 ILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLS 362
ILGVHLKDL+A+ + PDW + ++N KM QL L EL + + ++ N DL++
Sbjct: 301 ILGVHLKDLIAVHVIFPDWTE--ENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLIN 358
Query: 363 LLTVSLDQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQA 421
LLT+SLD Y TED++Y+LSL EPR SKS PTSPT+ P +P V EW PK D
Sbjct: 359 LLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTT---PNKPVVPLEWALGVMPKPDPT 415
Query: 422 LVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMV 481
++ +HI K+VESVFRN+D D DG+ISQE+F+ I NFP+L +F LD++QDG IS++EM+
Sbjct: 416 VINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMM 475
Query: 482 SYFLRSSSVLGGRM--GFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQ 539
+YFLR+ S L +M GF+HNFQE L+P C HC + GI KQG KC+ CG NCHKQ
Sbjct: 476 AYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQ 535
Query: 540 CKDRLSVECRRRAQSVSL---EGSAPSPSPMHSHHHRAFSFSLPRPGRR 585
CKD L + CRR A++ SL GS P + F F G R
Sbjct: 536 CKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHR 584
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 607 bits (1566), Expect = e-174
Identities = 312/589 (52%), Positives = 407/589 (69%), Gaps = 12/589 (2%)
Query: 3 GTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQ 62
G+ L K T++ELL CIE FDD+G++ + L R+ L+MH WY+ S++LA KLL +Y+
Sbjct: 2 GSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRN 61
Query: 63 SRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDID 122
+ ++ N ++K C+ +RYWI FPAEF+L+ L +E + + Q G +H SLIDI
Sbjct: 62 ATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDIS 121
Query: 123 SVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFV 182
S+P+Y W R+VTQR V KK K LLFDHLEP+ELAEHLT+LE++SF +I F DY S+V
Sbjct: 122 SIPSYDWMRRVTQRKKVS-KKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 180
Query: 183 THGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNT 242
HGC +NP LER I+LFN +S+WVQLM+LSKPT QRA VIT F++VA+KLLQL+NFNT
Sbjct: 181 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 240
Query: 243 LMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFP 302
LMAVVGGLSHSSISRLKETHSH+S E K W +TELV++ GNY NYR+ A C GF+ P
Sbjct: 241 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 300
Query: 303 ILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLS 362
ILGVHLKDL+A+ + PDW + ++N KM QL L EL + + ++ N DL++
Sbjct: 301 ILGVHLKDLIAVHVIFPDWTE--ENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLIN 358
Query: 363 LLTVSLDQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQA 421
LLT+SLD Y TED++Y+LSL EPR SKS PTSPT+ P +P V EW PK D
Sbjct: 359 LLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTT---PNKPVVPLEWALGVMPKPDPT 415
Query: 422 LVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMV 481
++ +HI K+VESVFRN+D D DG+ISQE+F+ I NFP+L +F LD++QDG IS++EM+
Sbjct: 416 VINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMM 475
Query: 482 SYFLRSSSVLGGRM--GFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQ 539
+YFLR+ S L +M GF+HNFQE L+P C HC + GI KQG KC+ CG NCHKQ
Sbjct: 476 AYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQ 535
Query: 540 CKDRLSVECRRRAQSVSL---EGSAPSPSPMHSHHHRAFSFSLPRPGRR 585
CKD L + CRR A++ SL GS P + F F G R
Sbjct: 536 CKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHR 584
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 515 bits (1327), Expect = e-146
Identities = 256/551 (46%), Positives = 375/551 (68%), Gaps = 12/551 (2%)
Query: 7 LDKGCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRK 65
L KG ++++L+ CI++FD G + R QL+++ L MH I S++L K++ +Y+ +
Sbjct: 56 LAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALA 115
Query: 66 DNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIDSVP 125
NS L +K C+ VRYWI+ F F ++ L + ++E + L+ +G H LID +
Sbjct: 116 KNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQIN 175
Query: 126 TYKWKRQVTQRNPVG-QKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTH 184
W R++TQR KKRK+SLLFDHLEP EL+EHLTYLE++SF +I F DY +++ +
Sbjct: 176 ARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVN 235
Query: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244
C +NP +ER I+L N +SQWVQLM+LS+PT RA V F+ VA+KL QLQNFNTLM
Sbjct: 236 SCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLM 295
Query: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304
AV+GGL HSSISRLKET SHV E K+ +TEL++++ NY NYRR C F+ PIL
Sbjct: 296 AVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPIL 355
Query: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364
GVHLKDL++L A+PD+L+ ++N K+ L++ + EL + + PP++AN DL+ LL
Sbjct: 356 GVHLKDLISLYEAMPDYLEDG--KVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLL 413
Query: 365 TVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVV 424
T+SLD Y TEDE+Y+LS REPR+ +P P +PPV+ +W S PK D +
Sbjct: 414 TLSLDLYYTEDEIYELSYAREPRNHRAPP-----LTPSKPPVVVDWASGVSPKPDPKTIS 468
Query: 425 EHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMVSYF 484
+H+++MV+SVF+N+D D DG+ISQEEF+ I +FP+ +F +D++++G ISR+E+ +YF
Sbjct: 469 KHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYF 526
Query: 485 LRSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDR 543
+R+SS+ +GF HNFQE+ L+P C +C + G+ KQG +C+ CG+NCHKQCKD
Sbjct: 527 MRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDL 586
Query: 544 LSVECRRRAQS 554
+ EC++RA++
Sbjct: 587 VVFECKKRAKN 597
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 471 bits (1213), Expect = e-133
Identities = 244/551 (44%), Positives = 354/551 (64%), Gaps = 47/551 (8%)
Query: 7 LDKGCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRK 65
L KG ++++L+ CI++FD G + R QL+++ L MH I S++L K++ +Y+ +
Sbjct: 56 LAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALA 115
Query: 66 DNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIDSVP 125
NS L +K C+ VRYWI+ F F ++ L + ++E + L+ +G H LID +
Sbjct: 116 KNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQIN 175
Query: 126 TYKWKRQVTQRNPVG-QKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTH 184
W R++TQR KKRK+SLLFDHLEP EL+EHLTYLE++SF +I F DY +++ +
Sbjct: 176 ARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVN 235
Query: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244
C +NP +ER I+L N +SQWVQLM+LS+PT RA V F+ VA+KL QLQNFNTLM
Sbjct: 236 SCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLM 295
Query: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304
AV+GGL HSSISRLKET SHV E K+ +TEL++++ NY NYRR C F+ PIL
Sbjct: 296 AVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPIL 355
Query: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364
GVHLKDL++L A+PD+L+ ++N K+ L++ + EL + + PP++AN DL+ LL
Sbjct: 356 GVHLKDLISLYEAMPDYLEDG--KVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLL 413
Query: 365 TVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVV 424
T+SLD Y TEDE+Y+LS REPR+ +P
Sbjct: 414 TLSLDLYYTEDEIYELSYAREPRNHRAP-------------------------------- 441
Query: 425 EHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMVSYF 484
SVF+N+D D DG+ISQEEF+ I +FP+ +F +D++++G ISR+E+ +YF
Sbjct: 442 --------SVFKNYDHDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYF 491
Query: 485 LRSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDR 543
+R+SS+ +GF HNFQE+ L+P C +C + G+ KQG +C+ CG+NCHKQCKD
Sbjct: 492 MRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDL 551
Query: 544 LSVECRRRAQS 554
+ EC++RA++
Sbjct: 552 VVFECKKRAKN 562
>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
sapiens]
Length = 659
Score = 465 bits (1197), Expect = e-131
Identities = 251/561 (44%), Positives = 340/561 (60%), Gaps = 25/561 (4%)
Query: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
Query: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIDSVPTYK 128
+++ CHLVRYW+ P +P+L E I A + +EGN L D +P
Sbjct: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLPGLG 174
Query: 129 WKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTV 188
KKRK+SLLFDHLE ELA+HLTYLE+RSF I QD S+V G
Sbjct: 175 -------------KKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVR 221
Query: 189 DNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVG 248
P LE + L NSVS+WVQ+M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV G
Sbjct: 222 GCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTG 281
Query: 249 GLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHL 308
GL HS+ISRLK++H+H+SP++ K LTEL+ + NY YRR A C GFR P+LGVHL
Sbjct: 282 GLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHL 341
Query: 309 KDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSL 368
KDLV+L A PD L R L K+ L+ L+EL + PP AN DLL LLT+SL
Sbjct: 342 KDLVSLHEAQPDRLPDGRLHL--PKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSL 399
Query: 369 DQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVVEHI 427
D + TEDE+Y+LS REPR KS P SP + P++ EW PK D+ + H+
Sbjct: 400 DLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLGRHV 453
Query: 428 EKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY-LSAFGDLDQNQDGCISREEMVSYFLR 486
E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+ Y LR
Sbjct: 454 EQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLR 513
Query: 487 SSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLS 545
+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C+D++
Sbjct: 514 ASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVK 573
Query: 546 VECRRRAQSVSLEGSAPSPSP 566
VEC++R + G +P P
Sbjct: 574 VECKKRPGAKGDAGPPGAPVP 594
>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
Length = 673
Score = 464 bits (1193), Expect = e-130
Identities = 252/562 (44%), Positives = 343/562 (61%), Gaps = 13/562 (2%)
Query: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
Query: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
Query: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF I QD S+V G
Sbjct: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSV 234
Query: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247
P LE + L NSVS+WVQ+M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV
Sbjct: 235 RGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 294
Query: 248 GGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVH 307
GGL HS+ISRLK++H+H+SP++ K LTEL+ + NY YRR A C GFR P+LGVH
Sbjct: 295 GGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVH 354
Query: 308 LKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVS 367
LKDLV+L A PD L R L K+ L+ L+EL + PP AN DLL LLT+S
Sbjct: 355 LKDLVSLHEAQPDRLPDGRLHL--PKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLS 412
Query: 368 LDQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVVEH 426
LD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+ + H
Sbjct: 413 LDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLGRH 466
Query: 427 IEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY-LSAFGDLDQNQDGCISREEMVSYFL 485
+E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+ Y L
Sbjct: 467 VEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLL 526
Query: 486 RSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRL 544
R+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C+D++
Sbjct: 527 RASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQV 586
Query: 545 SVECRRRAQSVSLEGSAPSPSP 566
VEC++R + G +P P
Sbjct: 587 KVECKKRPGAKGDAGPPGAPVP 608
>gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo
sapiens]
Length = 639
Score = 421 bits (1083), Expect = e-118
Identities = 236/562 (41%), Positives = 325/562 (57%), Gaps = 47/562 (8%)
Query: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
Query: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
Query: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF
Sbjct: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSF----------------- 217
Query: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247
Q + +M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV
Sbjct: 218 -----------------QAITVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 260
Query: 248 GGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVH 307
GGL HS+ISRLK++H+H+SP++ K LTEL+ + NY YRR A C GFR P+LGVH
Sbjct: 261 GGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVH 320
Query: 308 LKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVS 367
LKDLV+L A PD L R L K+ L+ L+EL + PP AN DLL LLT+S
Sbjct: 321 LKDLVSLHEAQPDRLPDGRLHL--PKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLS 378
Query: 368 LDQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVVEH 426
LD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+ + H
Sbjct: 379 LDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLGRH 432
Query: 427 IEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY-LSAFGDLDQNQDGCISREEMVSYFL 485
+E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+ Y L
Sbjct: 433 VEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLL 492
Query: 486 RSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRL 544
R+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C+D++
Sbjct: 493 RASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQV 552
Query: 545 SVECRRRAQSVSLEGSAPSPSP 566
VEC++R + G +P P
Sbjct: 553 KVECKKRPGAKGDAGPPGAPVP 574
>gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo
sapiens]
Length = 576
Score = 239 bits (610), Expect = 5e-63
Identities = 127/294 (43%), Positives = 173/294 (58%), Gaps = 11/294 (3%)
Query: 276 LTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMK 335
LTEL+ + NY YRR A C GFR P+LGVHLKDLV+L A PD L R L K+
Sbjct: 226 LTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHL--PKLN 283
Query: 336 QLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRS-KSSPTS 394
L+ L+EL + PP AN DLL LLT+SLD + TEDE+Y+LS REPR KS P S
Sbjct: 284 NLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPS 343
Query: 395 PTSCTPPPRPPVLEEWTSAAKPKLDQALVVEHIEKMVESVFRNFDVDGDGHISQEEFQII 454
P + P++ EW PK D+ + H+E++VESVF+N+D +G G ISQE+F+ +
Sbjct: 344 PFNA------PLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERL 397
Query: 455 RGNFPYLS-AFGDLDQNQDGCISREEMVSYFLRSSSVLGGR-MGFVHNFQESNSLRPVAC 512
GNFP+ + G SREE+ Y LR+S++ + F+H F E +P C
Sbjct: 398 SGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFC 457
Query: 513 RHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLEGSAPSPSP 566
C + G+ KQG +CR CG+ CHK C+D++ VEC++R + G +P P
Sbjct: 458 DSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVP 511
Score = 125 bits (313), Expect = 1e-28
Identities = 69/163 (42%), Positives = 97/163 (59%), Gaps = 2/163 (1%)
Query: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
Query: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID-IDSVPTY 127
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
Query: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSF 170
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF
Sbjct: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSF 217
>gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo
sapiens]
Length = 581
Score = 233 bits (595), Expect = 3e-61
Identities = 126/265 (47%), Positives = 171/265 (64%), Gaps = 2/265 (0%)
Query: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
Query: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
Query: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF I QD S+V G
Sbjct: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSV 234
Query: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247
P LE + L NSVS+WVQ+M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV
Sbjct: 235 RGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 294
Query: 248 GGLSHSSISRLKETHSHVSPETIKL 272
GGL HS+ISRLK++H+H+SP++ KL
Sbjct: 295 GGLCHSAISRLKDSHAHLSPDSTKL 319
Score = 159 bits (401), Expect = 9e-39
Identities = 81/204 (39%), Positives = 119/204 (58%), Gaps = 9/204 (4%)
Query: 366 VSLDQYQTEDELYQLSLQREPRS-KSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVV 424
+SLD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+ +
Sbjct: 319 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLG 372
Query: 425 EHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLS-AFGDLDQNQDGCISREEMVSY 483
H+E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+ Y
Sbjct: 373 RHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGY 432
Query: 484 FLRSSSVLGGR-MGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKD 542
LR+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C+D
Sbjct: 433 LLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRD 492
Query: 543 RLSVECRRRAQSVSLEGSAPSPSP 566
++ VEC++R + G +P P
Sbjct: 493 QVKVECKKRPGAKGDAGPPGAPVP 516
>gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo
sapiens]
Length = 604
Score = 233 bits (593), Expect = 5e-61
Identities = 129/279 (46%), Positives = 175/279 (62%), Gaps = 8/279 (2%)
Query: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
Query: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
Query: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF I QD S+V G
Sbjct: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSV 234
Query: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247
P LE + L NSVS+WVQ+M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV
Sbjct: 235 RGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 294
Query: 248 GGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNY 286
GGL HS+ISRLK++H+H+SP++ K ELV G +
Sbjct: 295 GGLCHSAISRLKDSHAHLSPDSTK------ELVALQGQH 327
Score = 180 bits (456), Expect = 4e-45
Identities = 93/228 (40%), Positives = 133/228 (58%), Gaps = 9/228 (3%)
Query: 342 EELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRS-KSSPTSPTSCTP 400
+EL + PP AN DLL LLT+SLD + TEDE+Y+LS REPR KS P SP +
Sbjct: 318 KELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNA-- 375
Query: 401 PPRPPVLEEWTSAAKPKLDQALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY 460
P++ EW PK D+ + H+E++VESVF+N+D +G G ISQE+F+ + GNFP+
Sbjct: 376 ----PLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPF 431
Query: 461 LS-AFGDLDQNQDGCISREEMVSYFLRSSSVLGGR-MGFVHNFQESNSLRPVACRHCKAL 518
+ G SREE+ Y LR+S++ + F+H F E +P C C
Sbjct: 432 ACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGF 491
Query: 519 ILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLEGSAPSPSP 566
+ G+ KQG +CR CG+ CHK C+D++ VEC++R + G +P P
Sbjct: 492 LWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVP 539
>gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo
sapiens]
Length = 484
Score = 161 bits (408), Expect = 1e-39
Identities = 82/206 (39%), Positives = 121/206 (58%), Gaps = 9/206 (4%)
Query: 364 LTVSLDQYQTEDELYQLSLQREPRS-KSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQAL 422
+T+SLD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+
Sbjct: 220 ITLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVT 273
Query: 423 VVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLS-AFGDLDQNQDGCISREEMV 481
+ H+E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+
Sbjct: 274 LGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELT 333
Query: 482 SYFLRSSSVLGGR-MGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540
Y LR+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C
Sbjct: 334 GYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHC 393
Query: 541 KDRLSVECRRRAQSVSLEGSAPSPSP 566
+D++ VEC++R + G +P P
Sbjct: 394 RDQVKVECKKRPGAKGDAGPPGAPVP 419
Score = 125 bits (313), Expect = 1e-28
Identities = 69/163 (42%), Positives = 97/163 (59%), Gaps = 2/163 (1%)
Query: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
Query: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID-IDSVPTY 127
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
Query: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSF 170
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF
Sbjct: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSF 217
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 102 bits (254), Expect = 1e-21
Identities = 85/326 (26%), Positives = 150/326 (46%), Gaps = 20/326 (6%)
Query: 74 KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHS---SLIDIDS 123
+ +++R+W+S +F+LN EL E++ LL QE + +L D
Sbjct: 917 RVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRALSQDDQ 976
Query: 124 VPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSF 181
+ + Q + + F+ L MELAE +T L++ F I ++++ +
Sbjct: 977 DDIHLKLEDIIQMTDCMKAE-----CFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGW 1031
Query: 182 VTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFN 241
+ P + + FN +S V I++ RA I +V VA+ L N+N
Sbjct: 1032 MKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYN 1091
Query: 242 TLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRF 301
++ + L+ S+I RLK+T + VS +T L + L + V++ G + N R L C
Sbjct: 1092 GVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAV 1151
Query: 302 PILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLL 361
P LG++L DL ++ P++ + +N +KM+ + I+ E+ + P +
Sbjct: 1152 PYLGMYLTDLAFIEEGTPNFTEEG--LVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVA 1209
Query: 362 SLLTVSLDQYQTEDELYQLSLQREPR 387
L + D ED LY+LSL+ EPR
Sbjct: 1210 QYL-LDKDLIIDEDTLYELSLKIEPR 1234
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 95.5 bits (236), Expect = 1e-19
Identities = 80/325 (24%), Positives = 149/325 (45%), Gaps = 18/325 (5%)
Query: 74 KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHSSLIDIDSVPT 126
+ +++R+W+S +F+ N EL E++ LL QE R+ ++ I
Sbjct: 937 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQE--RKAAANIIRTLTQE 994
Query: 127 YKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSFVTH 184
Q+T + + F++ +E+AE LT L++ F KI ++++ ++
Sbjct: 995 DPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKL 1054
Query: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244
P + + FN +S + I+ R I +V VA+ L N+N ++
Sbjct: 1055 EKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVL 1114
Query: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304
+ ++ S+I RLK+T VS +T L + L +LV++ G + N R L C P L
Sbjct: 1115 EITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYL 1174
Query: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364
G++L DL ++ P++ + +N +KM+ + I+ E+ ++ + L
Sbjct: 1175 GMYLTDLAFIEEGTPNYTEDG--LVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 1232
Query: 365 TVSLDQ--YQTEDELYQLSLQREPR 387
LDQ E+ LY+ SL+ EP+
Sbjct: 1233 ---LDQSFVMDEESLYESSLRIEPK 1254
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 95.5 bits (236), Expect = 1e-19
Identities = 80/325 (24%), Positives = 149/325 (45%), Gaps = 18/325 (5%)
Query: 74 KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHSSLIDIDSVPT 126
+ +++R+W+S +F+ N EL E++ LL QE R+ ++ I
Sbjct: 953 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQE--RKAAANIIRTLTQE 1010
Query: 127 YKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSFVTH 184
Q+T + + F++ +E+AE LT L++ F KI ++++ ++
Sbjct: 1011 DPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKL 1070
Query: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244
P + + FN +S + I+ R I +V VA+ L N+N ++
Sbjct: 1071 EKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVL 1130
Query: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304
+ ++ S+I RLK+T VS +T L + L +LV++ G + N R L C P L
Sbjct: 1131 EITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYL 1190
Query: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364
G++L DL ++ P++ + +N +KM+ + I+ E+ ++ + L
Sbjct: 1191 GMYLTDLAFIEEGTPNYTEDG--LVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 1248
Query: 365 TVSLDQ--YQTEDELYQLSLQREPR 387
LDQ E+ LY+ SL+ EP+
Sbjct: 1249 ---LDQSFVMDEESLYESSLRIEPK 1270
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 95.5 bits (236), Expect = 1e-19
Identities = 80/325 (24%), Positives = 149/325 (45%), Gaps = 18/325 (5%)
Query: 74 KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHSSLIDIDSVPT 126
+ +++R+W+S +F+ N EL E++ LL QE R+ ++ I
Sbjct: 169 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQE--RKAAANIIRTLTQE 226
Query: 127 YKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSFVTH 184
Q+T + + F++ +E+AE LT L++ F KI ++++ ++
Sbjct: 227 DPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKL 286
Query: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244
P + + FN +S + I+ R I +V VA+ L N+N ++
Sbjct: 287 EKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVL 346
Query: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304
+ ++ S+I RLK+T VS +T L + L +LV++ G + N R L C P L
Sbjct: 347 EITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYL 406
Query: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364
G++L DL ++ P++ + +N +KM+ + I+ E+ ++ + L
Sbjct: 407 GMYLTDLAFIEEGTPNYTEDG--LVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 464
Query: 365 TVSLDQ--YQTEDELYQLSLQREPR 387
LDQ E+ LY+ SL+ EP+
Sbjct: 465 ---LDQSFVMDEESLYESSLRIEPK 486
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 93.2 bits (230), Expect = 6e-19
Identities = 90/360 (25%), Positives = 160/360 (44%), Gaps = 23/360 (6%)
Query: 39 FLMMHPWYIPSSQLAAKLLHIYQQSRK--DNSNSLQVKTCHLVRYWISAFPAEFDLNPEL 96
FL + +I +L KL + Y++ D K V + +L E+
Sbjct: 737 FLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEI 796
Query: 97 AEQIKELKALLDQEGNRRHSSLID---IDSVPTYKWKRQVTQRNPVGQK--KRKMSLLFD 151
+ + EL L G + ++ +D V K R T P+ + + L D
Sbjct: 797 LKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHD 856
Query: 152 HLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMI 211
E+AE LT L+ F KI + + +P L +F FN++S WV+ +I
Sbjct: 857 -FHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSII 915
Query: 212 LSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIK 271
+ + A R ++ F+ + + L +L NFN+ +A++ L + I RL E S
Sbjct: 916 MLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL-EWQKQTS----- 969
Query: 272 LWEGLTE---LVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPARTR 328
EGL E L+ ++ ++ YR L+ P LG+ L+DL + L PD++D +
Sbjct: 970 --EGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYID---GK 1024
Query: 329 LNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRS 388
+N +K Q F+IL+ + ++ N D+++ + E+ L++LSL+ +PR+
Sbjct: 1025 VNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFN-DFSDHLAEEALWELSLKIKPRN 1083
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 93.2 bits (230), Expect = 6e-19
Identities = 90/360 (25%), Positives = 160/360 (44%), Gaps = 23/360 (6%)
Query: 39 FLMMHPWYIPSSQLAAKLLHIYQQSRK--DNSNSLQVKTCHLVRYWISAFPAEFDLNPEL 96
FL + +I +L KL + Y++ D K V + +L E+
Sbjct: 719 FLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEI 778
Query: 97 AEQIKELKALLDQEGNRRHSSLID---IDSVPTYKWKRQVTQRNPVGQK--KRKMSLLFD 151
+ + EL L G + ++ +D V K R T P+ + + L D
Sbjct: 779 LKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHD 838
Query: 152 HLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMI 211
E+AE LT L+ F KI + + +P L +F FN++S WV+ +I
Sbjct: 839 -FHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSII 897
Query: 212 LSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIK 271
+ + A R ++ F+ + + L +L NFN+ +A++ L + I RL E S
Sbjct: 898 MLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL-EWQKQTS----- 951
Query: 272 LWEGLTE---LVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPARTR 328
EGL E L+ ++ ++ YR L+ P LG+ L+DL + L PD++D +
Sbjct: 952 --EGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYID---GK 1006
Query: 329 LNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRS 388
+N +K Q F+IL+ + ++ N D+++ + E+ L++LSL+ +PR+
Sbjct: 1007 VNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFN-DFSDHLAEEALWELSLKIKPRN 1065
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 82.4 bits (202), Expect = 1e-15
Identities = 74/260 (28%), Positives = 120/260 (46%), Gaps = 24/260 (9%)
Query: 147 SLLFDHLE--PMELAEHLTYLEYRSF----------CKILFQDYHSFVTHGCTVDNPVLE 194
+++FD L+ P E A +T ++ F C ++ HS P +
Sbjct: 41 AVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLA--------PNVV 92
Query: 195 RFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSS 254
F FN VS WV IL+ T RA +++HFV +A+KLL+L N ++LM+VV L +
Sbjct: 93 AFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAP 152
Query: 255 ISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAAC-VGFRFPILGVHLKDLVA 313
I RL +T + ++ + +E L L++ NY R + + + P LG++L DL+
Sbjct: 153 IFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIY 212
Query: 314 LQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTS---LRPPVQANPDLLSLLTVSLDQ 370
+ A P +M + I+ +L + S L L S+ + Q
Sbjct: 213 IDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQ 272
Query: 371 YQTEDELYQLSLQREPRSKS 390
ED+ Y+LSL+ EP S S
Sbjct: 273 KFVEDDNYKLSLRIEPGSSS 292
>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
isoform 1 [Homo sapiens]
Length = 716
Score = 81.6 bits (200), Expect = 2e-15
Identities = 71/266 (26%), Positives = 120/266 (45%), Gaps = 29/266 (10%)
Query: 157 ELAEHLTYLEYRSFCKILFQDYHSFVTH-----GCTVDNPVLERFISLFNSVSQWVQLMI 211
E+AE LT ++ F K+ + V G +P + ++ FN+V+ V +
Sbjct: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
Query: 212 LSKP--TAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPET 269
L P APQRA + ++ +A++ +L+NF++L A++ L + I RLK + VS E
Sbjct: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
Query: 270 IKLWEGLTELVTATGNYGNYRRRL---AACVGFR-----------------FPILGVHLK 309
+ + L+++ + N+ + R L A G + P LG L
Sbjct: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
Query: 310 DLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLD 369
DLV L ALPD L+ +N K ++ + IL + + +P L +
Sbjct: 430 DLVMLDTALPDMLE--GDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQ 487
Query: 370 QYQTEDELYQLSLQREPRSKSSPTSP 395
TE++ Y+LS EP + S P+SP
Sbjct: 488 NQLTEEQSYRLSRVIEPPAASCPSSP 513
>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
isoform 2 [Homo sapiens]
Length = 710
Score = 81.6 bits (200), Expect = 2e-15
Identities = 71/266 (26%), Positives = 120/266 (45%), Gaps = 29/266 (10%)
Query: 157 ELAEHLTYLEYRSFCKILFQDYHSFVTH-----GCTVDNPVLERFISLFNSVSQWVQLMI 211
E+AE LT ++ F K+ + V G +P + ++ FN+V+ V +
Sbjct: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
Query: 212 LSKP--TAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPET 269
L P APQRA + ++ +A++ +L+NF++L A++ L + I RLK + VS E
Sbjct: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
Query: 270 IKLWEGLTELVTATGNYGNYRRRL---AACVGFR-----------------FPILGVHLK 309
+ + L+++ + N+ + R L A G + P LG L
Sbjct: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
Query: 310 DLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLD 369
DLV L ALPD L+ +N K ++ + IL + + +P L +
Sbjct: 430 DLVMLDTALPDMLE--GDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQ 487
Query: 370 QYQTEDELYQLSLQREPRSKSSPTSP 395
TE++ Y+LS EP + S P+SP
Sbjct: 488 NQLTEEQSYRLSRVIEPPAASCPSSP 513
>gi|24307909 ral guanine nucleotide dissociation stimulator isoform
1 [Homo sapiens]
Length = 914
Score = 81.6 bits (200), Expect = 2e-15
Identities = 78/324 (24%), Positives = 137/324 (42%), Gaps = 44/324 (13%)
Query: 129 WKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTV 188
W V N + ++K + L+F P +AE T ++ F K++ YH +
Sbjct: 365 WPSPVVAENGLSEEKPHL-LVFP---PDLVAEQFTLMDAELFKKVV--PYHCLGSIWSQR 418
Query: 189 DN-------PVLERFISLFNSVSQWVQLMILSKPT--APQRALVITHFVHVAEKLLQLQN 239
D P + ++ FNSV+ V L + AP RA V+ H++ VA + L+N
Sbjct: 419 DKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKN 478
Query: 240 FNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRL------ 293
F++L A++ L +SI RLK+T VS ++ ++++ L+E+ + NY R L
Sbjct: 479 FSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTS 538
Query: 294 ------------------AACVGFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMK 335
+ P LG L DLV L A+ D+L +N K +
Sbjct: 539 KFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYL--YGRLINFEKRR 596
Query: 336 QLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSP 395
+ F ++ ++ ++ S PD + +E E Y LS + EP S+S +
Sbjct: 597 KEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSES---AS 653
Query: 396 TSCTPPPRPPVLEEWTSAAKPKLD 419
+ +++ W+ P +
Sbjct: 654 NTLRTKKNTAIVKRWSDRQAPSTE 677
>gi|108796058 ral guanine nucleotide dissociation stimulator isoform
2 [Homo sapiens]
Length = 859
Score = 81.6 bits (200), Expect = 2e-15
Identities = 78/324 (24%), Positives = 137/324 (42%), Gaps = 44/324 (13%)
Query: 129 WKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTV 188
W V N + ++K + L+F P +AE T ++ F K++ YH +
Sbjct: 310 WPSPVVAENGLSEEKPHL-LVFP---PDLVAEQFTLMDAELFKKVV--PYHCLGSIWSQR 363
Query: 189 DN-------PVLERFISLFNSVSQWVQLMILSKPT--APQRALVITHFVHVAEKLLQLQN 239
D P + ++ FNSV+ V L + AP RA V+ H++ VA + L+N
Sbjct: 364 DKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKN 423
Query: 240 FNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRL------ 293
F++L A++ L +SI RLK+T VS ++ ++++ L+E+ + NY R L
Sbjct: 424 FSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTS 483
Query: 294 ------------------AACVGFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMK 335
+ P LG L DLV L A+ D+L +N K +
Sbjct: 484 KFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYL--YGRLINFEKRR 541
Query: 336 QLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSP 395
+ F ++ ++ ++ S PD + +E E Y LS + EP S+S +
Sbjct: 542 KEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSES---AS 598
Query: 396 TSCTPPPRPPVLEEWTSAAKPKLD 419
+ +++ W+ P +
Sbjct: 599 NTLRTKKNTAIVKRWSDRQAPSTE 622
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 79.7 bits (195), Expect = 7e-15
Identities = 64/209 (30%), Positives = 96/209 (45%), Gaps = 12/209 (5%)
Query: 196 FISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSI 255
F FN VS WV IL T RA V++H++ A+KL +L N + LMAVV GL + I
Sbjct: 93 FTRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPI 152
Query: 256 SRLKETHSHVSPETIKLWEGLTELVTATGNYGNYR-----RRLAACVGFRFPILGVHLKD 310
RL +T + +S + +E L +++ NY R ++ C+ P LG++L D
Sbjct: 153 FRLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCI----PYLGIYLSD 208
Query: 311 LVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPV--QANPDLLSLLTVSL 368
L + A P M + I+ +L P+ L S+ +
Sbjct: 209 LTYIDSAYPSTGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEE 268
Query: 369 DQYQTEDELYQLSLQREPRSKSSPTSPTS 397
Q ED+ Y+LSL+ EP S+P S S
Sbjct: 269 LQKFVEDDNYKLSLKIEP-GTSTPRSAAS 296
>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
[Homo sapiens]
Length = 803
Score = 77.4 bits (189), Expect = 4e-14
Identities = 102/460 (22%), Positives = 185/460 (40%), Gaps = 93/460 (20%)
Query: 9 KGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY-------- 60
K T+E+L+ + AF D+ D + +FL + + + ++ LL Y
Sbjct: 105 KAGTLEKLVENLLTAFGDN----DFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPNC 160
Query: 61 ----QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALL----DQEGN 112
QS ++ ++ ++R W+ +F P K L L +
Sbjct: 161 EEDGSQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPE 220
Query: 113 RRHSSLIDIDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPME--------------L 158
RR +L++ K++V N + +S + E +E +
Sbjct: 221 RRAQNLLEQFQ------KQEVETDNGL---PNTISFSLEEEEELEGGESAEFTCFSEDLV 271
Query: 159 AEHLTYLEYRSFCKILFQDYHSFVTHGCTVDN----------PVLERFISLFNSVSQWVQ 208
AE LTY++ + F K++ +H GC P + IS FN++++ V
Sbjct: 272 AEQLTYMDAQLFKKVV--PHHCL---GCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 326
Query: 209 LMILS--KPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVS 266
IL + QRA +I ++++A + L+NF++L A+V L +SI RLK+T + V
Sbjct: 327 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 386
Query: 267 PETIKLWEGLTELVTATGNYGNYRRRLAACVGFRF------------------------- 301
+ + ++E L+++ + N+ R L +F
Sbjct: 387 RDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMG 446
Query: 302 ------PILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQ 355
P LG L DL L AL D+++ +N K ++ F ++ ++ ++ S
Sbjct: 447 VMQGTVPYLGTFLTDLTMLDTALQDYIEGGL--INFEKRRREFEVIAQIKLLQSACNSYC 504
Query: 356 ANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSP 395
PD + Q TE+E Y LS + E + +S TSP
Sbjct: 505 MTPDQKFIQWFQRQQLLTEEESYALSCEIEAAADASTTSP 544
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 70.1 bits (170), Expect = 6e-12
Identities = 98/403 (24%), Positives = 157/403 (38%), Gaps = 80/403 (19%)
Query: 40 LMMHPWYIPSSQLAAKLLHIYQQ--------SRKDNSNSLQVKTCHLVRYWISAFPAEF- 90
L MHP+ +L AK+ H+ + S K+ + K L+ W FP +F
Sbjct: 72 LFMHPY-----ELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTETFPYDFR 126
Query: 91 ---------DLNPELA---EQ-------------IKELKALLDQEGNRRHSSLIDIDSVP 125
DL +A EQ I++L AL E S D +
Sbjct: 127 DERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTSTDRLT 186
Query: 126 TYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHG 185
K K Q QR+ + +P LA+ LT++E I +++
Sbjct: 187 VLKTKPQSIQRDIITVCN----------DPYTLAQQLTHIELERLNYIGPEEFVQAFVQK 236
Query: 186 CTVDNPV-----------LERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKL 234
+DN LE ++ FN +S V I RA +I +F+ VA +
Sbjct: 237 DPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVAREC 296
Query: 235 LQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLA 294
+ NFN+LMA++ G++ S +SRLK+T + V +T K ++ L + + N+ NYR L
Sbjct: 297 FNIGNFNSLMAIISGMNMSPVSRLKKTWAKV--KTAK-FDILEHQMDPSSNFYNYRTALR 353
Query: 295 ACV-----------GFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEE 343
P + +KD+ L + L +N K +L + E
Sbjct: 354 GAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRL--PNGHVNFEKFWELAKQVSE 411
Query: 344 LAMVTSLRPPVQANPDLLS-LLTVSLDQYQTEDELYQLSLQRE 385
+ P + + +L LLTV + +ED LY S + E
Sbjct: 412 FMTWKQVECPFERDRKILQYLLTVPV---FSEDALYLASYESE 451
>gi|117168263 RasGEF domain family, member 1A [Homo sapiens]
Length = 481
Score = 70.1 bits (170), Expect = 6e-12
Identities = 88/405 (21%), Positives = 163/405 (40%), Gaps = 62/405 (15%)
Query: 32 DPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSR--------KDNSNSLQVKTCHLVRYWI 83
D + FL+ ++P L A++ I + + K S K L++ W
Sbjct: 66 DRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQLLKEWT 125
Query: 84 SAFPAEFDLNPELAEQIKELKALL------DQEGNR--------RHSSLIDIDSVPTYKW 129
AFP +F +AE LKA+ D+E S L+ + + +
Sbjct: 126 EAFPYDFQDEKAMAE----LKAITHRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQE 181
Query: 130 KRQ-----VTQRNPVGQKK---RKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSF 181
R+ + P+ + K + +L +P+ LA+ LT++E I +D
Sbjct: 182 LREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQI 241
Query: 182 VTHGCTVDNP----------VLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVA 231
V+H ++DN LE + + FN +S V + R ++ F+ VA
Sbjct: 242 VSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVA 301
Query: 232 EKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRR 291
+ + NFN++MA++ G++ S ++RLK+T S V +T K ++ L + + N+ NYR
Sbjct: 302 RECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV--KTAK-FDVLEHHMDPSSNFCNYRT 358
Query: 292 RLAACV-----------GFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSI 340
L P+ + +KD+ L + L +N K ++
Sbjct: 359 ALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHL--PNGHINFKKFWEISRQ 416
Query: 341 LEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQRE 385
+ E T + P + + + S L + +E+ L+ S + E
Sbjct: 417 IHEFMTWTQVECPFEKDKKIQSYLLTA--PIYSEEALFVASFESE 459
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,021,851
Number of Sequences: 37866
Number of extensions: 1181743
Number of successful extensions: 6334
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 128
Number of HSP's successfully gapped in prelim test: 103
Number of HSP's that attempted gapping in prelim test: 5827
Number of HSP's gapped (non-prelim): 471
length of query: 609
length of database: 18,247,518
effective HSP length: 108
effective length of query: 501
effective length of database: 14,157,990
effective search space: 7093152990
effective search space used: 7093152990
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.