BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] (609 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 1236 0.0 gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 1236 0.0 gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 1236 0.0 gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 609 e-174 gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 607 e-174 gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 607 e-174 gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 515 e-146 gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 471 e-133 gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi... 465 e-131 gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 464 e-130 gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo sapi... 421 e-118 gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo sapi... 239 5e-63 gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo sapi... 233 3e-61 gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo sapi... 233 5e-61 gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo sapi... 161 1e-39 gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 102 1e-21 gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 96 1e-19 gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 96 1e-19 gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 96 1e-19 gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 93 6e-19 gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 93 6e-19 gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 82 1e-15 gi|239582765 ral guanine nucleotide dissociation stimulator-like... 82 2e-15 gi|239582763 ral guanine nucleotide dissociation stimulator-like... 82 2e-15 gi|24307909 ral guanine nucleotide dissociation stimulator isofo... 82 2e-15 gi|108796058 ral guanine nucleotide dissociation stimulator isof... 82 2e-15 gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 80 7e-15 gi|93102367 ral guanine nucleotide dissociation stimulator-like ... 77 4e-14 gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 70 6e-12 gi|117168263 RasGEF domain family, member 1A [Homo sapiens] 70 6e-12 >gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] Length = 609 Score = 1236 bits (3197), Expect = 0.0 Identities = 609/609 (100%), Positives = 609/609 (100%) Query: 1 MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY 60 MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY Sbjct: 1 MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY 60 Query: 61 QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID 120 QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID Sbjct: 61 QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID 120 Query: 121 IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS 180 IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS Sbjct: 121 IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS 180 Query: 181 FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF 240 FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF Sbjct: 181 FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF 240 Query: 241 NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR 300 NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR Sbjct: 241 NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR 300 Query: 301 FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL 360 FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL Sbjct: 301 FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL 360 Query: 361 LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ 420 LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ Sbjct: 361 LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ 420 Query: 421 ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM 480 ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM Sbjct: 421 ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM 480 Query: 481 VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540 VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC Sbjct: 481 VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540 Query: 541 KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV 600 KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV Sbjct: 541 KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV 600 Query: 601 EDGVFDIHL 609 EDGVFDIHL Sbjct: 601 EDGVFDIHL 609 >gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] Length = 609 Score = 1236 bits (3197), Expect = 0.0 Identities = 609/609 (100%), Positives = 609/609 (100%) Query: 1 MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY 60 MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY Sbjct: 1 MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY 60 Query: 61 QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID 120 QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID Sbjct: 61 QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID 120 Query: 121 IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS 180 IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS Sbjct: 121 IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS 180 Query: 181 FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF 240 FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF Sbjct: 181 FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF 240 Query: 241 NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR 300 NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR Sbjct: 241 NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR 300 Query: 301 FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL 360 FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL Sbjct: 301 FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL 360 Query: 361 LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ 420 LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ Sbjct: 361 LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ 420 Query: 421 ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM 480 ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM Sbjct: 421 ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM 480 Query: 481 VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540 VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC Sbjct: 481 VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540 Query: 541 KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV 600 KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV Sbjct: 541 KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV 600 Query: 601 EDGVFDIHL 609 EDGVFDIHL Sbjct: 601 EDGVFDIHL 609 >gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] Length = 609 Score = 1236 bits (3197), Expect = 0.0 Identities = 609/609 (100%), Positives = 609/609 (100%) Query: 1 MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY 60 MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY Sbjct: 1 MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY 60 Query: 61 QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID 120 QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID Sbjct: 61 QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID 120 Query: 121 IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS 180 IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS Sbjct: 121 IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS 180 Query: 181 FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF 240 FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF Sbjct: 181 FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF 240 Query: 241 NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR 300 NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR Sbjct: 241 NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR 300 Query: 301 FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL 360 FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL Sbjct: 301 FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL 360 Query: 361 LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ 420 LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ Sbjct: 361 LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ 420 Query: 421 ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM 480 ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM Sbjct: 421 ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM 480 Query: 481 VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540 VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC Sbjct: 481 VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540 Query: 541 KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV 600 KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV Sbjct: 541 KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV 600 Query: 601 EDGVFDIHL 609 EDGVFDIHL Sbjct: 601 EDGVFDIHL 609 >gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regulated) isoform 2 [Homo sapiens] Length = 689 Score = 609 bits (1570), Expect = e-174 Identities = 310/588 (52%), Positives = 406/588 (69%), Gaps = 11/588 (1%) Query: 3 GTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQ 62 G+ L K T++ELL CIE FDD+G++ + L R+ L+MH WY+ S++LA KLL +Y+ Sbjct: 2 GSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRN 61 Query: 63 SRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDID 122 + ++ N ++K C+ +RYWI FPAEF+L+ L +E + + Q G +H SLIDI Sbjct: 62 ATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDIS 121 Query: 123 SVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFV 182 S+P+Y W R+VTQR V KK K LLFDHLEP+ELAEHLT+LE++SF +I F DY S+V Sbjct: 122 SIPSYDWMRRVTQRKKVS-KKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 180 Query: 183 THGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNT 242 HGC +NP LER I+LFN +S+WVQLM+LSKPT QRA VIT F++VA+KLLQL+NFNT Sbjct: 181 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 240 Query: 243 LMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFP 302 LMAVVGGLSHSSISRLKETHSH+S E K W +TELV++ GNY NYR+ A C GF+ P Sbjct: 241 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 300 Query: 303 ILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLS 362 ILGVHLKDL+A+ + PDW + ++N KM QL L EL + + ++ N DL++ Sbjct: 301 ILGVHLKDLIAVHVIFPDWTE--ENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLIN 358 Query: 363 LLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQAL 422 LLT+SLD Y TED++Y+LSL EPR+ SPTSPT+ P +P V EW PK D + Sbjct: 359 LLTLSLDLYHTEDDIYKLSLVLEPRNSKSPTSPTT---PNKPVVPLEWALGVMPKPDPTV 415 Query: 423 VVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMVS 482 + +HI K+VESVFRN+D D DG+ISQE+F+ I NFP+L +F LD++QDG IS++EM++ Sbjct: 416 INKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMA 475 Query: 483 YFLRSSSVLGGRM--GFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540 YFLR+ S L +M GF+HNFQE L+P C HC + GI KQG KC+ CG NCHKQC Sbjct: 476 YFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQC 535 Query: 541 KDRLSVECRRRAQSVSL---EGSAPSPSPMHSHHHRAFSFSLPRPGRR 585 KD L + CRR A++ SL GS P + F F G R Sbjct: 536 KDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHR 583 >gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-regulated) isoform 1 [Homo sapiens] Length = 690 Score = 607 bits (1566), Expect = e-174 Identities = 312/589 (52%), Positives = 407/589 (69%), Gaps = 12/589 (2%) Query: 3 GTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQ 62 G+ L K T++ELL CIE FDD+G++ + L R+ L+MH WY+ S++LA KLL +Y+ Sbjct: 2 GSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRN 61 Query: 63 SRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDID 122 + ++ N ++K C+ +RYWI FPAEF+L+ L +E + + Q G +H SLIDI Sbjct: 62 ATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDIS 121 Query: 123 SVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFV 182 S+P+Y W R+VTQR V KK K LLFDHLEP+ELAEHLT+LE++SF +I F DY S+V Sbjct: 122 SIPSYDWMRRVTQRKKVS-KKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 180 Query: 183 THGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNT 242 HGC +NP LER I+LFN +S+WVQLM+LSKPT QRA VIT F++VA+KLLQL+NFNT Sbjct: 181 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 240 Query: 243 LMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFP 302 LMAVVGGLSHSSISRLKETHSH+S E K W +TELV++ GNY NYR+ A C GF+ P Sbjct: 241 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 300 Query: 303 ILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLS 362 ILGVHLKDL+A+ + PDW + ++N KM QL L EL + + ++ N DL++ Sbjct: 301 ILGVHLKDLIAVHVIFPDWTE--ENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLIN 358 Query: 363 LLTVSLDQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQA 421 LLT+SLD Y TED++Y+LSL EPR SKS PTSPT+ P +P V EW PK D Sbjct: 359 LLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTT---PNKPVVPLEWALGVMPKPDPT 415 Query: 422 LVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMV 481 ++ +HI K+VESVFRN+D D DG+ISQE+F+ I NFP+L +F LD++QDG IS++EM+ Sbjct: 416 VINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMM 475 Query: 482 SYFLRSSSVLGGRM--GFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQ 539 +YFLR+ S L +M GF+HNFQE L+P C HC + GI KQG KC+ CG NCHKQ Sbjct: 476 AYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQ 535 Query: 540 CKDRLSVECRRRAQSVSL---EGSAPSPSPMHSHHHRAFSFSLPRPGRR 585 CKD L + CRR A++ SL GS P + F F G R Sbjct: 536 CKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHR 584 >gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regulated) isoform 1 [Homo sapiens] Length = 690 Score = 607 bits (1566), Expect = e-174 Identities = 312/589 (52%), Positives = 407/589 (69%), Gaps = 12/589 (2%) Query: 3 GTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQ 62 G+ L K T++ELL CIE FDD+G++ + L R+ L+MH WY+ S++LA KLL +Y+ Sbjct: 2 GSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRN 61 Query: 63 SRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDID 122 + ++ N ++K C+ +RYWI FPAEF+L+ L +E + + Q G +H SLIDI Sbjct: 62 ATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDIS 121 Query: 123 SVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFV 182 S+P+Y W R+VTQR V KK K LLFDHLEP+ELAEHLT+LE++SF +I F DY S+V Sbjct: 122 SIPSYDWMRRVTQRKKVS-KKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 180 Query: 183 THGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNT 242 HGC +NP LER I+LFN +S+WVQLM+LSKPT QRA VIT F++VA+KLLQL+NFNT Sbjct: 181 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 240 Query: 243 LMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFP 302 LMAVVGGLSHSSISRLKETHSH+S E K W +TELV++ GNY NYR+ A C GF+ P Sbjct: 241 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 300 Query: 303 ILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLS 362 ILGVHLKDL+A+ + PDW + ++N KM QL L EL + + ++ N DL++ Sbjct: 301 ILGVHLKDLIAVHVIFPDWTE--ENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLIN 358 Query: 363 LLTVSLDQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQA 421 LLT+SLD Y TED++Y+LSL EPR SKS PTSPT+ P +P V EW PK D Sbjct: 359 LLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTT---PNKPVVPLEWALGVMPKPDPT 415 Query: 422 LVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMV 481 ++ +HI K+VESVFRN+D D DG+ISQE+F+ I NFP+L +F LD++QDG IS++EM+ Sbjct: 416 VINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMM 475 Query: 482 SYFLRSSSVLGGRM--GFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQ 539 +YFLR+ S L +M GF+HNFQE L+P C HC + GI KQG KC+ CG NCHKQ Sbjct: 476 AYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQ 535 Query: 540 CKDRLSVECRRRAQSVSL---EGSAPSPSPMHSHHHRAFSFSLPRPGRR 585 CKD L + CRR A++ SL GS P + F F G R Sbjct: 536 CKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHR 584 >gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapiens] Length = 797 Score = 515 bits (1327), Expect = e-146 Identities = 256/551 (46%), Positives = 375/551 (68%), Gaps = 12/551 (2%) Query: 7 LDKGCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRK 65 L KG ++++L+ CI++FD G + R QL+++ L MH I S++L K++ +Y+ + Sbjct: 56 LAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALA 115 Query: 66 DNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIDSVP 125 NS L +K C+ VRYWI+ F F ++ L + ++E + L+ +G H LID + Sbjct: 116 KNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQIN 175 Query: 126 TYKWKRQVTQRNPVG-QKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTH 184 W R++TQR KKRK+SLLFDHLEP EL+EHLTYLE++SF +I F DY +++ + Sbjct: 176 ARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVN 235 Query: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244 C +NP +ER I+L N +SQWVQLM+LS+PT RA V F+ VA+KL QLQNFNTLM Sbjct: 236 SCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLM 295 Query: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304 AV+GGL HSSISRLKET SHV E K+ +TEL++++ NY NYRR C F+ PIL Sbjct: 296 AVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPIL 355 Query: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364 GVHLKDL++L A+PD+L+ ++N K+ L++ + EL + + PP++AN DL+ LL Sbjct: 356 GVHLKDLISLYEAMPDYLEDG--KVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLL 413 Query: 365 TVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVV 424 T+SLD Y TEDE+Y+LS REPR+ +P P +PPV+ +W S PK D + Sbjct: 414 TLSLDLYYTEDEIYELSYAREPRNHRAPP-----LTPSKPPVVVDWASGVSPKPDPKTIS 468 Query: 425 EHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMVSYF 484 +H+++MV+SVF+N+D D DG+ISQEEF+ I +FP+ +F +D++++G ISR+E+ +YF Sbjct: 469 KHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYF 526 Query: 485 LRSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDR 543 +R+SS+ +GF HNFQE+ L+P C +C + G+ KQG +C+ CG+NCHKQCKD Sbjct: 527 MRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDL 586 Query: 544 LSVECRRRAQS 554 + EC++RA++ Sbjct: 587 VVFECKKRAKN 597 >gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapiens] Length = 762 Score = 471 bits (1213), Expect = e-133 Identities = 244/551 (44%), Positives = 354/551 (64%), Gaps = 47/551 (8%) Query: 7 LDKGCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRK 65 L KG ++++L+ CI++FD G + R QL+++ L MH I S++L K++ +Y+ + Sbjct: 56 LAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALA 115 Query: 66 DNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIDSVP 125 NS L +K C+ VRYWI+ F F ++ L + ++E + L+ +G H LID + Sbjct: 116 KNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQIN 175 Query: 126 TYKWKRQVTQRNPVG-QKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTH 184 W R++TQR KKRK+SLLFDHLEP EL+EHLTYLE++SF +I F DY +++ + Sbjct: 176 ARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVN 235 Query: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244 C +NP +ER I+L N +SQWVQLM+LS+PT RA V F+ VA+KL QLQNFNTLM Sbjct: 236 SCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLM 295 Query: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304 AV+GGL HSSISRLKET SHV E K+ +TEL++++ NY NYRR C F+ PIL Sbjct: 296 AVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPIL 355 Query: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364 GVHLKDL++L A+PD+L+ ++N K+ L++ + EL + + PP++AN DL+ LL Sbjct: 356 GVHLKDLISLYEAMPDYLEDG--KVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLL 413 Query: 365 TVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVV 424 T+SLD Y TEDE+Y+LS REPR+ +P Sbjct: 414 TLSLDLYYTEDEIYELSYAREPRNHRAP-------------------------------- 441 Query: 425 EHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMVSYF 484 SVF+N+D D DG+ISQEEF+ I +FP+ +F +D++++G ISR+E+ +YF Sbjct: 442 --------SVFKNYDHDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYF 491 Query: 485 LRSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDR 543 +R+SS+ +GF HNFQE+ L+P C +C + G+ KQG +C+ CG+NCHKQCKD Sbjct: 492 MRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDL 551 Query: 544 LSVECRRRAQS 554 + EC++RA++ Sbjct: 552 VVFECKKRAKN 562 >gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapiens] Length = 659 Score = 465 bits (1197), Expect = e-131 Identities = 251/561 (44%), Positives = 340/561 (60%), Gaps = 25/561 (4%) Query: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68 GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D Sbjct: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114 Query: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIDSVPTYK 128 +++ CHLVRYW+ P +P+L E I A + +EGN L D +P Sbjct: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLPGLG 174 Query: 129 WKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTV 188 KKRK+SLLFDHLE ELA+HLTYLE+RSF I QD S+V G Sbjct: 175 -------------KKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVR 221 Query: 189 DNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVG 248 P LE + L NSVS+WVQ+M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV G Sbjct: 222 GCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTG 281 Query: 249 GLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHL 308 GL HS+ISRLK++H+H+SP++ K LTEL+ + NY YRR A C GFR P+LGVHL Sbjct: 282 GLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHL 341 Query: 309 KDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSL 368 KDLV+L A PD L R L K+ L+ L+EL + PP AN DLL LLT+SL Sbjct: 342 KDLVSLHEAQPDRLPDGRLHL--PKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSL 399 Query: 369 DQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVVEHI 427 D + TEDE+Y+LS REPR KS P SP + P++ EW PK D+ + H+ Sbjct: 400 DLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLGRHV 453 Query: 428 EKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY-LSAFGDLDQNQDGCISREEMVSYFLR 486 E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+ Y LR Sbjct: 454 EQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLR 513 Query: 487 SSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLS 545 +S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C+D++ Sbjct: 514 ASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVK 573 Query: 546 VECRRRAQSVSLEGSAPSPSP 566 VEC++R + G +P P Sbjct: 574 VECKKRPGAKGDAGPPGAPVP 594 >gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] Length = 673 Score = 464 bits (1193), Expect = e-130 Identities = 252/562 (44%), Positives = 343/562 (61%), Gaps = 13/562 (2%) Query: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68 GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D Sbjct: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114 Query: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127 +++ CHLVRYW+ P +P+L E I A + +EGN L D D + Sbjct: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174 Query: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187 + +P KKRK+SLLFDHLE ELA+HLTYLE+RSF I QD S+V G Sbjct: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSV 234 Query: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247 P LE + L NSVS+WVQ+M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV Sbjct: 235 RGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 294 Query: 248 GGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVH 307 GGL HS+ISRLK++H+H+SP++ K LTEL+ + NY YRR A C GFR P+LGVH Sbjct: 295 GGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVH 354 Query: 308 LKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVS 367 LKDLV+L A PD L R L K+ L+ L+EL + PP AN DLL LLT+S Sbjct: 355 LKDLVSLHEAQPDRLPDGRLHL--PKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLS 412 Query: 368 LDQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVVEH 426 LD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+ + H Sbjct: 413 LDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLGRH 466 Query: 427 IEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY-LSAFGDLDQNQDGCISREEMVSYFL 485 +E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+ Y L Sbjct: 467 VEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLL 526 Query: 486 RSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRL 544 R+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C+D++ Sbjct: 527 RASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQV 586 Query: 545 SVECRRRAQSVSLEGSAPSPSP 566 VEC++R + G +P P Sbjct: 587 KVECKKRPGAKGDAGPPGAPVP 608 >gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo sapiens] Length = 639 Score = 421 bits (1083), Expect = e-118 Identities = 236/562 (41%), Positives = 325/562 (57%), Gaps = 47/562 (8%) Query: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68 GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D Sbjct: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114 Query: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127 +++ CHLVRYW+ P +P+L E I A + +EGN L D D + Sbjct: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174 Query: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187 + +P KKRK+SLLFDHLE ELA+HLTYLE+RSF Sbjct: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSF----------------- 217 Query: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247 Q + +M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV Sbjct: 218 -----------------QAITVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 260 Query: 248 GGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVH 307 GGL HS+ISRLK++H+H+SP++ K LTEL+ + NY YRR A C GFR P+LGVH Sbjct: 261 GGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVH 320 Query: 308 LKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVS 367 LKDLV+L A PD L R L K+ L+ L+EL + PP AN DLL LLT+S Sbjct: 321 LKDLVSLHEAQPDRLPDGRLHL--PKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLS 378 Query: 368 LDQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVVEH 426 LD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+ + H Sbjct: 379 LDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLGRH 432 Query: 427 IEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY-LSAFGDLDQNQDGCISREEMVSYFL 485 +E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+ Y L Sbjct: 433 VEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLL 492 Query: 486 RSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRL 544 R+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C+D++ Sbjct: 493 RASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQV 552 Query: 545 SVECRRRAQSVSLEGSAPSPSP 566 VEC++R + G +P P Sbjct: 553 KVECKKRPGAKGDAGPPGAPVP 574 >gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo sapiens] Length = 576 Score = 239 bits (610), Expect = 5e-63 Identities = 127/294 (43%), Positives = 173/294 (58%), Gaps = 11/294 (3%) Query: 276 LTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMK 335 LTEL+ + NY YRR A C GFR P+LGVHLKDLV+L A PD L R L K+ Sbjct: 226 LTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHL--PKLN 283 Query: 336 QLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRS-KSSPTS 394 L+ L+EL + PP AN DLL LLT+SLD + TEDE+Y+LS REPR KS P S Sbjct: 284 NLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPS 343 Query: 395 PTSCTPPPRPPVLEEWTSAAKPKLDQALVVEHIEKMVESVFRNFDVDGDGHISQEEFQII 454 P + P++ EW PK D+ + H+E++VESVF+N+D +G G ISQE+F+ + Sbjct: 344 PFNA------PLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERL 397 Query: 455 RGNFPYLS-AFGDLDQNQDGCISREEMVSYFLRSSSVLGGR-MGFVHNFQESNSLRPVAC 512 GNFP+ + G SREE+ Y LR+S++ + F+H F E +P C Sbjct: 398 SGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFC 457 Query: 513 RHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLEGSAPSPSP 566 C + G+ KQG +CR CG+ CHK C+D++ VEC++R + G +P P Sbjct: 458 DSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVP 511 Score = 125 bits (313), Expect = 1e-28 Identities = 69/163 (42%), Positives = 97/163 (59%), Gaps = 2/163 (1%) Query: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68 GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D Sbjct: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114 Query: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID-IDSVPTY 127 +++ CHLVRYW+ P +P+L E I A + +EGN L D D + Sbjct: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174 Query: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSF 170 + +P KKRK+SLLFDHLE ELA+HLTYLE+RSF Sbjct: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSF 217 >gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo sapiens] Length = 581 Score = 233 bits (595), Expect = 3e-61 Identities = 126/265 (47%), Positives = 171/265 (64%), Gaps = 2/265 (0%) Query: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68 GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D Sbjct: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114 Query: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127 +++ CHLVRYW+ P +P+L E I A + +EGN L D D + Sbjct: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174 Query: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187 + +P KKRK+SLLFDHLE ELA+HLTYLE+RSF I QD S+V G Sbjct: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSV 234 Query: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247 P LE + L NSVS+WVQ+M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV Sbjct: 235 RGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 294 Query: 248 GGLSHSSISRLKETHSHVSPETIKL 272 GGL HS+ISRLK++H+H+SP++ KL Sbjct: 295 GGLCHSAISRLKDSHAHLSPDSTKL 319 Score = 159 bits (401), Expect = 9e-39 Identities = 81/204 (39%), Positives = 119/204 (58%), Gaps = 9/204 (4%) Query: 366 VSLDQYQTEDELYQLSLQREPRS-KSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVV 424 +SLD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+ + Sbjct: 319 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVTLG 372 Query: 425 EHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLS-AFGDLDQNQDGCISREEMVSY 483 H+E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+ Y Sbjct: 373 RHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGY 432 Query: 484 FLRSSSVLGGR-MGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKD 542 LR+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C+D Sbjct: 433 LLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRD 492 Query: 543 RLSVECRRRAQSVSLEGSAPSPSP 566 ++ VEC++R + G +P P Sbjct: 493 QVKVECKKRPGAKGDAGPPGAPVP 516 >gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo sapiens] Length = 604 Score = 233 bits (593), Expect = 5e-61 Identities = 129/279 (46%), Positives = 175/279 (62%), Gaps = 8/279 (2%) Query: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68 GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D Sbjct: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114 Query: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127 +++ CHLVRYW+ P +P+L E I A + +EGN L D D + Sbjct: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174 Query: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187 + +P KKRK+SLLFDHLE ELA+HLTYLE+RSF I QD S+V G Sbjct: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSV 234 Query: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247 P LE + L NSVS+WVQ+M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV Sbjct: 235 RGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 294 Query: 248 GGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNY 286 GGL HS+ISRLK++H+H+SP++ K ELV G + Sbjct: 295 GGLCHSAISRLKDSHAHLSPDSTK------ELVALQGQH 327 Score = 180 bits (456), Expect = 4e-45 Identities = 93/228 (40%), Positives = 133/228 (58%), Gaps = 9/228 (3%) Query: 342 EELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRS-KSSPTSPTSCTP 400 +EL + PP AN DLL LLT+SLD + TEDE+Y+LS REPR KS P SP + Sbjct: 318 KELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNA-- 375 Query: 401 PPRPPVLEEWTSAAKPKLDQALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY 460 P++ EW PK D+ + H+E++VESVF+N+D +G G ISQE+F+ + GNFP+ Sbjct: 376 ----PLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPF 431 Query: 461 LS-AFGDLDQNQDGCISREEMVSYFLRSSSVLGGR-MGFVHNFQESNSLRPVACRHCKAL 518 + G SREE+ Y LR+S++ + F+H F E +P C C Sbjct: 432 ACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGF 491 Query: 519 ILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLEGSAPSPSP 566 + G+ KQG +CR CG+ CHK C+D++ VEC++R + G +P P Sbjct: 492 LWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVP 539 >gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo sapiens] Length = 484 Score = 161 bits (408), Expect = 1e-39 Identities = 82/206 (39%), Positives = 121/206 (58%), Gaps = 9/206 (4%) Query: 364 LTVSLDQYQTEDELYQLSLQREPRS-KSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQAL 422 +T+SLD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+ Sbjct: 220 ITLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVT 273 Query: 423 VVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLS-AFGDLDQNQDGCISREEMV 481 + H+E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+ Sbjct: 274 LGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELT 333 Query: 482 SYFLRSSSVLGGR-MGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540 Y LR+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C Sbjct: 334 GYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHC 393 Query: 541 KDRLSVECRRRAQSVSLEGSAPSPSP 566 +D++ VEC++R + G +P P Sbjct: 394 RDQVKVECKKRPGAKGDAGPPGAPVP 419 Score = 125 bits (313), Expect = 1e-28 Identities = 69/163 (42%), Positives = 97/163 (59%), Gaps = 2/163 (1%) Query: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68 GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D Sbjct: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114 Query: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID-IDSVPTY 127 +++ CHLVRYW+ P +P+L E I A + +EGN L D D + Sbjct: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174 Query: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSF 170 + +P KKRK+SLLFDHLE ELA+HLTYLE+RSF Sbjct: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSF 217 >gi|38505170 Ras protein-specific guanine nucleotide-releasing factor 2 [Homo sapiens] Length = 1237 Score = 102 bits (254), Expect = 1e-21 Identities = 85/326 (26%), Positives = 150/326 (46%), Gaps = 20/326 (6%) Query: 74 KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHS---SLIDIDS 123 + +++R+W+S +F+LN EL E++ LL QE + +L D Sbjct: 917 RVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRALSQDDQ 976 Query: 124 VPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSF 181 + + Q + + F+ L MELAE +T L++ F I ++++ + Sbjct: 977 DDIHLKLEDIIQMTDCMKAE-----CFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGW 1031 Query: 182 VTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFN 241 + P + + FN +S V I++ RA I +V VA+ L N+N Sbjct: 1032 MKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYN 1091 Query: 242 TLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRF 301 ++ + L+ S+I RLK+T + VS +T L + L + V++ G + N R L C Sbjct: 1092 GVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAV 1151 Query: 302 PILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLL 361 P LG++L DL ++ P++ + +N +KM+ + I+ E+ + P + Sbjct: 1152 PYLGMYLTDLAFIEEGTPNFTEEG--LVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVA 1209 Query: 362 SLLTVSLDQYQTEDELYQLSLQREPR 387 L + D ED LY+LSL+ EPR Sbjct: 1210 QYL-LDKDLIIDEDTLYELSLKIEPR 1234 >gi|224586880 Ras protein-specific guanine nucleotide-releasing factor 1 isoform 3 [Homo sapiens] Length = 1257 Score = 95.5 bits (236), Expect = 1e-19 Identities = 80/325 (24%), Positives = 149/325 (45%), Gaps = 18/325 (5%) Query: 74 KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHSSLIDIDSVPT 126 + +++R+W+S +F+ N EL E++ LL QE R+ ++ I Sbjct: 937 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQE--RKAAANIIRTLTQE 994 Query: 127 YKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSFVTH 184 Q+T + + F++ +E+AE LT L++ F KI ++++ ++ Sbjct: 995 DPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKL 1054 Query: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244 P + + FN +S + I+ R I +V VA+ L N+N ++ Sbjct: 1055 EKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVL 1114 Query: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304 + ++ S+I RLK+T VS +T L + L +LV++ G + N R L C P L Sbjct: 1115 EITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYL 1174 Query: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364 G++L DL ++ P++ + +N +KM+ + I+ E+ ++ + L Sbjct: 1175 GMYLTDLAFIEEGTPNYTEDG--LVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 1232 Query: 365 TVSLDQ--YQTEDELYQLSLQREPR 387 LDQ E+ LY+ SL+ EP+ Sbjct: 1233 ---LDQSFVMDEESLYESSLRIEPK 1254 >gi|24797099 Ras protein-specific guanine nucleotide-releasing factor 1 isoform 1 [Homo sapiens] Length = 1273 Score = 95.5 bits (236), Expect = 1e-19 Identities = 80/325 (24%), Positives = 149/325 (45%), Gaps = 18/325 (5%) Query: 74 KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHSSLIDIDSVPT 126 + +++R+W+S +F+ N EL E++ LL QE R+ ++ I Sbjct: 953 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQE--RKAAANIIRTLTQE 1010 Query: 127 YKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSFVTH 184 Q+T + + F++ +E+AE LT L++ F KI ++++ ++ Sbjct: 1011 DPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKL 1070 Query: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244 P + + FN +S + I+ R I +V VA+ L N+N ++ Sbjct: 1071 EKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVL 1130 Query: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304 + ++ S+I RLK+T VS +T L + L +LV++ G + N R L C P L Sbjct: 1131 EITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYL 1190 Query: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364 G++L DL ++ P++ + +N +KM+ + I+ E+ ++ + L Sbjct: 1191 GMYLTDLAFIEEGTPNYTEDG--LVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 1248 Query: 365 TVSLDQ--YQTEDELYQLSLQREPR 387 LDQ E+ LY+ SL+ EP+ Sbjct: 1249 ---LDQSFVMDEESLYESSLRIEPK 1270 >gi|24797101 Ras protein-specific guanine nucleotide-releasing factor 1 isoform 2 [Homo sapiens] Length = 489 Score = 95.5 bits (236), Expect = 1e-19 Identities = 80/325 (24%), Positives = 149/325 (45%), Gaps = 18/325 (5%) Query: 74 KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHSSLIDIDSVPT 126 + +++R+W+S +F+ N EL E++ LL QE R+ ++ I Sbjct: 169 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQE--RKAAANIIRTLTQE 226 Query: 127 YKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSFVTH 184 Q+T + + F++ +E+AE LT L++ F KI ++++ ++ Sbjct: 227 DPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKL 286 Query: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244 P + + FN +S + I+ R I +V VA+ L N+N ++ Sbjct: 287 EKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVL 346 Query: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304 + ++ S+I RLK+T VS +T L + L +LV++ G + N R L C P L Sbjct: 347 EITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYL 406 Query: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364 G++L DL ++ P++ + +N +KM+ + I+ E+ ++ + L Sbjct: 407 GMYLTDLAFIEEGTPNYTEDG--LVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 464 Query: 365 TVSLDQ--YQTEDELYQLSLQREPR 387 LDQ E+ LY+ SL+ EP+ Sbjct: 465 ---LDQSFVMDEESLYESSLRIEPK 486 >gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo sapiens] Length = 1095 Score = 93.2 bits (230), Expect = 6e-19 Identities = 90/360 (25%), Positives = 160/360 (44%), Gaps = 23/360 (6%) Query: 39 FLMMHPWYIPSSQLAAKLLHIYQQSRK--DNSNSLQVKTCHLVRYWISAFPAEFDLNPEL 96 FL + +I +L KL + Y++ D K V + +L E+ Sbjct: 737 FLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEI 796 Query: 97 AEQIKELKALLDQEGNRRHSSLID---IDSVPTYKWKRQVTQRNPVGQK--KRKMSLLFD 151 + + EL L G + ++ +D V K R T P+ + + L D Sbjct: 797 LKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHD 856 Query: 152 HLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMI 211 E+AE LT L+ F KI + + +P L +F FN++S WV+ +I Sbjct: 857 -FHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSII 915 Query: 212 LSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIK 271 + + A R ++ F+ + + L +L NFN+ +A++ L + I RL E S Sbjct: 916 MLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL-EWQKQTS----- 969 Query: 272 LWEGLTE---LVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPARTR 328 EGL E L+ ++ ++ YR L+ P LG+ L+DL + L PD++D + Sbjct: 970 --EGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYID---GK 1024 Query: 329 LNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRS 388 +N +K Q F+IL+ + ++ N D+++ + E+ L++LSL+ +PR+ Sbjct: 1025 VNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFN-DFSDHLAEEALWELSLKIKPRN 1083 >gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo sapiens] Length = 1077 Score = 93.2 bits (230), Expect = 6e-19 Identities = 90/360 (25%), Positives = 160/360 (44%), Gaps = 23/360 (6%) Query: 39 FLMMHPWYIPSSQLAAKLLHIYQQSRK--DNSNSLQVKTCHLVRYWISAFPAEFDLNPEL 96 FL + +I +L KL + Y++ D K V + +L E+ Sbjct: 719 FLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEI 778 Query: 97 AEQIKELKALLDQEGNRRHSSLID---IDSVPTYKWKRQVTQRNPVGQK--KRKMSLLFD 151 + + EL L G + ++ +D V K R T P+ + + L D Sbjct: 779 LKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHD 838 Query: 152 HLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMI 211 E+AE LT L+ F KI + + +P L +F FN++S WV+ +I Sbjct: 839 -FHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSII 897 Query: 212 LSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIK 271 + + A R ++ F+ + + L +L NFN+ +A++ L + I RL E S Sbjct: 898 MLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL-EWQKQTS----- 951 Query: 272 LWEGLTE---LVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPARTR 328 EGL E L+ ++ ++ YR L+ P LG+ L+DL + L PD++D + Sbjct: 952 --EGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYID---GK 1006 Query: 329 LNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRS 388 +N +K Q F+IL+ + ++ N D+++ + E+ L++LSL+ +PR+ Sbjct: 1007 VNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFN-DFSDHLAEEALWELSLKIKPRN 1065 >gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo sapiens] Length = 557 Score = 82.4 bits (202), Expect = 1e-15 Identities = 74/260 (28%), Positives = 120/260 (46%), Gaps = 24/260 (9%) Query: 147 SLLFDHLE--PMELAEHLTYLEYRSF----------CKILFQDYHSFVTHGCTVDNPVLE 194 +++FD L+ P E A +T ++ F C ++ HS P + Sbjct: 41 AVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLA--------PNVV 92 Query: 195 RFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSS 254 F FN VS WV IL+ T RA +++HFV +A+KLL+L N ++LM+VV L + Sbjct: 93 AFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAP 152 Query: 255 ISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAAC-VGFRFPILGVHLKDLVA 313 I RL +T + ++ + +E L L++ NY R + + + P LG++L DL+ Sbjct: 153 IFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIY 212 Query: 314 LQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTS---LRPPVQANPDLLSLLTVSLDQ 370 + A P +M + I+ +L + S L L S+ + Q Sbjct: 213 IDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQ 272 Query: 371 YQTEDELYQLSLQREPRSKS 390 ED+ Y+LSL+ EP S S Sbjct: 273 KFVEDDNYKLSLRIEPGSSS 292 >gi|239582765 ral guanine nucleotide dissociation stimulator-like 3 isoform 1 [Homo sapiens] Length = 716 Score = 81.6 bits (200), Expect = 2e-15 Identities = 71/266 (26%), Positives = 120/266 (45%), Gaps = 29/266 (10%) Query: 157 ELAEHLTYLEYRSFCKILFQDYHSFVTH-----GCTVDNPVLERFISLFNSVSQWVQLMI 211 E+AE LT ++ F K+ + V G +P + ++ FN+V+ V + Sbjct: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309 Query: 212 LSKP--TAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPET 269 L P APQRA + ++ +A++ +L+NF++L A++ L + I RLK + VS E Sbjct: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369 Query: 270 IKLWEGLTELVTATGNYGNYRRRL---AACVGFR-----------------FPILGVHLK 309 + + L+++ + N+ + R L A G + P LG L Sbjct: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429 Query: 310 DLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLD 369 DLV L ALPD L+ +N K ++ + IL + + +P L + Sbjct: 430 DLVMLDTALPDMLE--GDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQ 487 Query: 370 QYQTEDELYQLSLQREPRSKSSPTSP 395 TE++ Y+LS EP + S P+SP Sbjct: 488 NQLTEEQSYRLSRVIEPPAASCPSSP 513 >gi|239582763 ral guanine nucleotide dissociation stimulator-like 3 isoform 2 [Homo sapiens] Length = 710 Score = 81.6 bits (200), Expect = 2e-15 Identities = 71/266 (26%), Positives = 120/266 (45%), Gaps = 29/266 (10%) Query: 157 ELAEHLTYLEYRSFCKILFQDYHSFVTH-----GCTVDNPVLERFISLFNSVSQWVQLMI 211 E+AE LT ++ F K+ + V G +P + ++ FN+V+ V + Sbjct: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309 Query: 212 LSKP--TAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPET 269 L P APQRA + ++ +A++ +L+NF++L A++ L + I RLK + VS E Sbjct: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369 Query: 270 IKLWEGLTELVTATGNYGNYRRRL---AACVGFR-----------------FPILGVHLK 309 + + L+++ + N+ + R L A G + P LG L Sbjct: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429 Query: 310 DLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLD 369 DLV L ALPD L+ +N K ++ + IL + + +P L + Sbjct: 430 DLVMLDTALPDMLE--GDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQ 487 Query: 370 QYQTEDELYQLSLQREPRSKSSPTSP 395 TE++ Y+LS EP + S P+SP Sbjct: 488 NQLTEEQSYRLSRVIEPPAASCPSSP 513 >gi|24307909 ral guanine nucleotide dissociation stimulator isoform 1 [Homo sapiens] Length = 914 Score = 81.6 bits (200), Expect = 2e-15 Identities = 78/324 (24%), Positives = 137/324 (42%), Gaps = 44/324 (13%) Query: 129 WKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTV 188 W V N + ++K + L+F P +AE T ++ F K++ YH + Sbjct: 365 WPSPVVAENGLSEEKPHL-LVFP---PDLVAEQFTLMDAELFKKVV--PYHCLGSIWSQR 418 Query: 189 DN-------PVLERFISLFNSVSQWVQLMILSKPT--APQRALVITHFVHVAEKLLQLQN 239 D P + ++ FNSV+ V L + AP RA V+ H++ VA + L+N Sbjct: 419 DKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKN 478 Query: 240 FNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRL------ 293 F++L A++ L +SI RLK+T VS ++ ++++ L+E+ + NY R L Sbjct: 479 FSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTS 538 Query: 294 ------------------AACVGFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMK 335 + P LG L DLV L A+ D+L +N K + Sbjct: 539 KFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYL--YGRLINFEKRR 596 Query: 336 QLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSP 395 + F ++ ++ ++ S PD + +E E Y LS + EP S+S + Sbjct: 597 KEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSES---AS 653 Query: 396 TSCTPPPRPPVLEEWTSAAKPKLD 419 + +++ W+ P + Sbjct: 654 NTLRTKKNTAIVKRWSDRQAPSTE 677 >gi|108796058 ral guanine nucleotide dissociation stimulator isoform 2 [Homo sapiens] Length = 859 Score = 81.6 bits (200), Expect = 2e-15 Identities = 78/324 (24%), Positives = 137/324 (42%), Gaps = 44/324 (13%) Query: 129 WKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTV 188 W V N + ++K + L+F P +AE T ++ F K++ YH + Sbjct: 310 WPSPVVAENGLSEEKPHL-LVFP---PDLVAEQFTLMDAELFKKVV--PYHCLGSIWSQR 363 Query: 189 DN-------PVLERFISLFNSVSQWVQLMILSKPT--APQRALVITHFVHVAEKLLQLQN 239 D P + ++ FNSV+ V L + AP RA V+ H++ VA + L+N Sbjct: 364 DKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKN 423 Query: 240 FNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRL------ 293 F++L A++ L +SI RLK+T VS ++ ++++ L+E+ + NY R L Sbjct: 424 FSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTS 483 Query: 294 ------------------AACVGFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMK 335 + P LG L DLV L A+ D+L +N K + Sbjct: 484 KFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYL--YGRLINFEKRR 541 Query: 336 QLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSP 395 + F ++ ++ ++ S PD + +E E Y LS + EP S+S + Sbjct: 542 KEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSES---AS 598 Query: 396 TSCTPPPRPPVLEEWTSAAKPKLD 419 + +++ W+ P + Sbjct: 599 NTLRTKKNTAIVKRWSDRQAPSTE 622 >gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo sapiens] Length = 583 Score = 79.7 bits (195), Expect = 7e-15 Identities = 64/209 (30%), Positives = 96/209 (45%), Gaps = 12/209 (5%) Query: 196 FISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSI 255 F FN VS WV IL T RA V++H++ A+KL +L N + LMAVV GL + I Sbjct: 93 FTRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPI 152 Query: 256 SRLKETHSHVSPETIKLWEGLTELVTATGNYGNYR-----RRLAACVGFRFPILGVHLKD 310 RL +T + +S + +E L +++ NY R ++ C+ P LG++L D Sbjct: 153 FRLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCI----PYLGIYLSD 208 Query: 311 LVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPV--QANPDLLSLLTVSL 368 L + A P M + I+ +L P+ L S+ + Sbjct: 209 LTYIDSAYPSTGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEE 268 Query: 369 DQYQTEDELYQLSLQREPRSKSSPTSPTS 397 Q ED+ Y+LSL+ EP S+P S S Sbjct: 269 LQKFVEDDNYKLSLKIEP-GTSTPRSAAS 296 >gi|93102367 ral guanine nucleotide dissociation stimulator-like 1 [Homo sapiens] Length = 803 Score = 77.4 bits (189), Expect = 4e-14 Identities = 102/460 (22%), Positives = 185/460 (40%), Gaps = 93/460 (20%) Query: 9 KGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY-------- 60 K T+E+L+ + AF D+ D + +FL + + + ++ LL Y Sbjct: 105 KAGTLEKLVENLLTAFGDN----DFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPNC 160 Query: 61 ----QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALL----DQEGN 112 QS ++ ++ ++R W+ +F P K L L + Sbjct: 161 EEDGSQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPE 220 Query: 113 RRHSSLIDIDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPME--------------L 158 RR +L++ K++V N + +S + E +E + Sbjct: 221 RRAQNLLEQFQ------KQEVETDNGL---PNTISFSLEEEEELEGGESAEFTCFSEDLV 271 Query: 159 AEHLTYLEYRSFCKILFQDYHSFVTHGCTVDN----------PVLERFISLFNSVSQWVQ 208 AE LTY++ + F K++ +H GC P + IS FN++++ V Sbjct: 272 AEQLTYMDAQLFKKVV--PHHCL---GCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 326 Query: 209 LMILS--KPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVS 266 IL + QRA +I ++++A + L+NF++L A+V L +SI RLK+T + V Sbjct: 327 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 386 Query: 267 PETIKLWEGLTELVTATGNYGNYRRRLAACVGFRF------------------------- 301 + + ++E L+++ + N+ R L +F Sbjct: 387 RDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMG 446 Query: 302 ------PILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQ 355 P LG L DL L AL D+++ +N K ++ F ++ ++ ++ S Sbjct: 447 VMQGTVPYLGTFLTDLTMLDTALQDYIEGGL--INFEKRRREFEVIAQIKLLQSACNSYC 504 Query: 356 ANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSP 395 PD + Q TE+E Y LS + E + +S TSP Sbjct: 505 MTPDQKFIQWFQRQQLLTEEESYALSCEIEAAADASTTSP 544 >gi|22749129 RasGEF domain family, member 1B [Homo sapiens] Length = 473 Score = 70.1 bits (170), Expect = 6e-12 Identities = 98/403 (24%), Positives = 157/403 (38%), Gaps = 80/403 (19%) Query: 40 LMMHPWYIPSSQLAAKLLHIYQQ--------SRKDNSNSLQVKTCHLVRYWISAFPAEF- 90 L MHP+ +L AK+ H+ + S K+ + K L+ W FP +F Sbjct: 72 LFMHPY-----ELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTETFPYDFR 126 Query: 91 ---------DLNPELA---EQ-------------IKELKALLDQEGNRRHSSLIDIDSVP 125 DL +A EQ I++L AL E S D + Sbjct: 127 DERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTSTDRLT 186 Query: 126 TYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHG 185 K K Q QR+ + +P LA+ LT++E I +++ Sbjct: 187 VLKTKPQSIQRDIITVCN----------DPYTLAQQLTHIELERLNYIGPEEFVQAFVQK 236 Query: 186 CTVDNPV-----------LERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKL 234 +DN LE ++ FN +S V I RA +I +F+ VA + Sbjct: 237 DPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVAREC 296 Query: 235 LQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLA 294 + NFN+LMA++ G++ S +SRLK+T + V +T K ++ L + + N+ NYR L Sbjct: 297 FNIGNFNSLMAIISGMNMSPVSRLKKTWAKV--KTAK-FDILEHQMDPSSNFYNYRTALR 353 Query: 295 ACV-----------GFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEE 343 P + +KD+ L + L +N K +L + E Sbjct: 354 GAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRL--PNGHVNFEKFWELAKQVSE 411 Query: 344 LAMVTSLRPPVQANPDLLS-LLTVSLDQYQTEDELYQLSLQRE 385 + P + + +L LLTV + +ED LY S + E Sbjct: 412 FMTWKQVECPFERDRKILQYLLTVPV---FSEDALYLASYESE 451 >gi|117168263 RasGEF domain family, member 1A [Homo sapiens] Length = 481 Score = 70.1 bits (170), Expect = 6e-12 Identities = 88/405 (21%), Positives = 163/405 (40%), Gaps = 62/405 (15%) Query: 32 DPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSR--------KDNSNSLQVKTCHLVRYWI 83 D + FL+ ++P L A++ I + + K S K L++ W Sbjct: 66 DRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQLLKEWT 125 Query: 84 SAFPAEFDLNPELAEQIKELKALL------DQEGNR--------RHSSLIDIDSVPTYKW 129 AFP +F +AE LKA+ D+E S L+ + + + Sbjct: 126 EAFPYDFQDEKAMAE----LKAITHRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQE 181 Query: 130 KRQ-----VTQRNPVGQKK---RKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSF 181 R+ + P+ + K + +L +P+ LA+ LT++E I +D Sbjct: 182 LREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQI 241 Query: 182 VTHGCTVDNP----------VLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVA 231 V+H ++DN LE + + FN +S V + R ++ F+ VA Sbjct: 242 VSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVA 301 Query: 232 EKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRR 291 + + NFN++MA++ G++ S ++RLK+T S V +T K ++ L + + N+ NYR Sbjct: 302 RECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV--KTAK-FDVLEHHMDPSSNFCNYRT 358 Query: 292 RLAACV-----------GFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSI 340 L P+ + +KD+ L + L +N K ++ Sbjct: 359 ALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHL--PNGHINFKKFWEISRQ 416 Query: 341 LEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQRE 385 + E T + P + + + S L + +E+ L+ S + E Sbjct: 417 IHEFMTWTQVECPFEKDKKIQSYLLTA--PIYSEEALFVASFESE 459 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.135 0.410 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 25,021,851 Number of Sequences: 37866 Number of extensions: 1181743 Number of successful extensions: 6334 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 128 Number of HSP's successfully gapped in prelim test: 103 Number of HSP's that attempted gapping in prelim test: 5827 Number of HSP's gapped (non-prelim): 471 length of query: 609 length of database: 18,247,518 effective HSP length: 108 effective length of query: 501 effective length of database: 14,157,990 effective search space: 7093152990 effective search space used: 7093152990 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.