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Search of human proteins with 148922949
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148922949 complement component (3b/4b) receptor 1-like [Homo
sapiens]
(569 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ... 1222 0.0
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 778 0.0
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi... 778 0.0
gi|54792123 complement component (3d/Epstein Barr virus) recepto... 269 6e-72
gi|42544177 complement component (3d/Epstein Barr virus) recepto... 248 8e-66
gi|4502503 complement component 4 binding protein, alpha chain p... 204 1e-52
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 202 5e-52
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 202 5e-52
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 197 2e-50
gi|148886654 polydom [Homo sapiens] 197 2e-50
gi|27502413 CD46 antigen, complement regulatory protein isoform ... 195 8e-50
gi|27502402 CD46 antigen, complement regulatory protein isoform ... 195 8e-50
gi|27502425 CD46 antigen, complement regulatory protein isoform ... 195 8e-50
gi|27502423 CD46 antigen, complement regulatory protein isoform ... 195 8e-50
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 193 4e-49
gi|27502421 CD46 antigen, complement regulatory protein isoform ... 191 2e-48
gi|27502417 CD46 antigen, complement regulatory protein isoform ... 191 2e-48
gi|27502415 CD46 antigen, complement regulatory protein isoform ... 191 2e-48
gi|27502407 CD46 antigen, complement regulatory protein isoform ... 191 2e-48
gi|24432108 CD46 antigen, complement regulatory protein isoform ... 191 2e-48
gi|27502411 CD46 antigen, complement regulatory protein isoform ... 190 3e-48
gi|27502409 CD46 antigen, complement regulatory protein isoform ... 190 3e-48
gi|27502405 CD46 antigen, complement regulatory protein isoform ... 190 3e-48
gi|27502419 CD46 antigen, complement regulatory protein isoform ... 189 4e-48
gi|27502427 CD46 antigen, complement regulatory protein isoform ... 189 4e-48
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 182 7e-46
gi|157419154 selectin P precursor [Homo sapiens] 162 6e-40
gi|168693643 decay accelerating factor for complement isoform 2 ... 155 9e-38
gi|10835143 decay accelerating factor for complement isoform 1 p... 155 9e-38
gi|187960042 selectin E precursor [Homo sapiens] 145 1e-34
>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
sapiens]
Length = 569
Score = 1222 bits (3161), Expect = 0.0
Identities = 569/569 (100%), Positives = 569/569 (100%)
Query: 1 MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY 60
MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY
Sbjct: 1 MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY 60
Query: 61 LNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIK 120
LNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIK
Sbjct: 61 LNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIK 120
Query: 121 YSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYG 180
YSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYG
Sbjct: 121 YSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYG 180
Query: 181 SVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGIL 240
SVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGIL
Sbjct: 181 SVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGIL 240
Query: 241 VSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAER 300
VSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAER
Sbjct: 241 VSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAER 300
Query: 301 TQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNG 360
TQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNG
Sbjct: 301 TQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNG 360
Query: 361 HVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPV 420
HVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPV
Sbjct: 361 HVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPV 420
Query: 421 NGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPA 480
NGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPA
Sbjct: 421 NGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPA 480
Query: 481 ILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPR 540
ILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPR
Sbjct: 481 ILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPR 540
Query: 541 CELPVGAGSHDALIVGKFYEVFAEEFCHL 569
CELPVGAGSHDALIVGKFYEVFAEEFCHL
Sbjct: 541 CELPVGAGSHDALIVGKFYEVFAEEFCHL 569
>gi|86793109 complement receptor 1 isoform S precursor [Homo
sapiens]
Length = 2489
Score = 778 bits (2009), Expect = 0.0
Identities = 391/539 (72%), Positives = 417/539 (77%), Gaps = 27/539 (5%)
Query: 18 GLLLAALVLLLSSFS-DQCNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSI 76
G LLA +VLL + QCN PEWLPFARPTNLTD+FEFPIGTYLNYECRPGYSGRPFSI
Sbjct: 25 GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRPFSI 84
Query: 77 ICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSAT 136
ICLKNSVWT AKD+C+RKSCRNPPDPVNGM HVIK IQF SQIKYSC KGYRLIGSSSAT
Sbjct: 85 ICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSAT 144
Query: 137 CIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKV 196
CIISG+TVIWDN+TP+CDRI CGLPPTI NGDF S +RE FHYGSVVTY CN GS G+KV
Sbjct: 145 CIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKV 204
Query: 197 FELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 256
FELVGEPSIYCTS DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF
Sbjct: 205 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 264
Query: 257 RCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFY 316
RCQPGF MKGP VKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFY
Sbjct: 265 RCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFY 324
Query: 317 SCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDF 376
SCEPGYDLRG+ + CTPQGDWSPAAP CEVKSCDDF+GQL NG VLFP+NLQLGAKVDF
Sbjct: 325 SCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDF 384
Query: 377 VCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHV---G 433
VCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE+ C +PPV NG H + V G
Sbjct: 385 VCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFG 443
Query: 434 SRINYSCT------TGHRLIGHSSAECIL--SGNTAHWSMKPPICQQI-FCPNPPAILNG 484
+NY+C T LIG S+ C GN WS P C + C P L
Sbjct: 444 KTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFA 502
Query: 485 R-HTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542
+ T T D P G + Y C P G F++ N VWSSP C+
Sbjct: 503 KLKTQTNASDFPIGTSLKYECRPE-YYGRPFSITCLD----------NLVWSSPKDVCK 550
Score = 689 bits (1778), Expect = 0.0
Identities = 349/521 (66%), Positives = 377/521 (72%), Gaps = 26/521 (4%)
Query: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRK 94
C P+ FA+ T+ +FPIGT L YECRP Y GRPFSI CL N VW+S KD CKRK
Sbjct: 493 CQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRK 552
Query: 95 SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCD 154
SC+ PPDPVNGM HVI DIQ S+I YSC G+RLIG SSA CI+SGN W K P+C
Sbjct: 553 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
Query: 155 RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQV 214
RI CGLPPTIANGDF S +RE FHYGSVVTY CN GS G+KVFELVGEPSIYCTS DDQV
Sbjct: 613 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQV 672
Query: 215 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF MKGP VKCQA
Sbjct: 673 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 732
Query: 275 LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTP 334
LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG+ + CTP
Sbjct: 733 LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTP 792
Query: 335 QGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVL 394
QGDWSPAAP CEVKSCDDF+GQL NG VLFP+NLQLGAKVDFVCDEGFQLKGSSASYCVL
Sbjct: 793 QGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVL 852
Query: 395 AGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHV---GSRINYSCT------TGHR 445
AGMESLWNSSVPVCE+ C +PPV NG H + V G +NY+C T
Sbjct: 853 AGMESLWNSSVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKTVNYTCDPHPDRGTSFD 911
Query: 446 LIGHSSAECIL--SGNTAHWSMKPPICQQI-FCPNPPAILNGR-HTGTPLGDIPYGKEVS 501
LIG S+ C GN WS P C + C P L + T T D P G +
Sbjct: 912 LIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLK 970
Query: 502 YTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542
Y C P G F++ N VWSSP C+
Sbjct: 971 YECRPE-YYGRPFSITCLD----------NLVWSSPKDVCK 1000
Score = 689 bits (1778), Expect = 0.0
Identities = 349/521 (66%), Positives = 377/521 (72%), Gaps = 26/521 (4%)
Query: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRK 94
C P+ FA+ T+ +FPIGT L YECRP Y GRPFSI CL N VW+S KD CKRK
Sbjct: 943 CQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRK 1002
Query: 95 SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCD 154
SC+ PPDPVNGM HVI DIQ S+I YSC G+RLIG SSA CI+SGN W K P+C
Sbjct: 1003 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 1062
Query: 155 RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQV 214
RI CGLPPTIANGDF S +RE FHYGSVVTY CN GS G+KVFELVGEPSIYCTS DDQV
Sbjct: 1063 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQV 1122
Query: 215 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF MKGP VKCQA
Sbjct: 1123 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 1182
Query: 275 LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTP 334
LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG+ + CTP
Sbjct: 1183 LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTP 1242
Query: 335 QGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVL 394
QGDWSPAAP CEVKSCDDF+GQL NG VLFP+NLQLGAKVDFVCDEGFQLKGSSASYCVL
Sbjct: 1243 QGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVL 1302
Query: 395 AGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHV---GSRINYSCT------TGHR 445
AGMESLWNSSVPVCE+ C +PPV NG H + V G +NY+C T
Sbjct: 1303 AGMESLWNSSVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKAVNYTCDPHPDRGTSFD 1361
Query: 446 LIGHSSAECIL--SGNTAHWSMKPPICQQI-FCPNPPAILNGR-HTGTPLGDIPYGKEVS 501
LIG S+ C GN WS P C + C P L + T T D P G +
Sbjct: 1362 LIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLK 1420
Query: 502 YTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542
Y C P G F++ N VWSSP C+
Sbjct: 1421 YECRPE-YYGRPFSITCLD----------NLVWSSPKDVCK 1450
Score = 667 bits (1722), Expect = 0.0
Identities = 338/524 (64%), Positives = 368/524 (70%), Gaps = 31/524 (5%)
Query: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRK 94
C P+ FA+ T+ +FPIGT L YECRP Y GRPFSI CL N VW+S KD CKRK
Sbjct: 1393 CQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRK 1452
Query: 95 SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCD 154
SC+ PPDPVNGM HVI DIQ S+I YSC G+RLIG SSA CI+SGNT W K P+C
Sbjct: 1453 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1512
Query: 155 RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQV 214
RI CGLPPTIANGDF S +RE FHYGSVVTY CNLGSRG+KVFELVGEPSIYCTS DDQV
Sbjct: 1513 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQV 1572
Query: 215 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF MKGP VKCQA
Sbjct: 1573 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 1632
Query: 275 LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTP 334
LNKWEPELPSCSRVCQPPP++LH E T +DNFSPGQEVFYSCEPGYDLRG+ LHCTP
Sbjct: 1633 LNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTP 1692
Query: 335 QGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVL 394
QGDWSP APRC VKSCDDFLGQLP+G VLFPLNLQLGAKV FVCDEGF+LKGSS S+CVL
Sbjct: 1693 QGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVL 1752
Query: 395 AGMESLWNSSVPVCERKSCETPPVPVNGMVHVIT---DIHVGSRINYSCT------TGHR 445
GM SLWN+SVPVCE C PP +NG H T DI G I+Y+C
Sbjct: 1753 VGMRSLWNNSVPVCEHIFCPNPPAILNGR-HTGTPSGDIPYGKEISYTCDPHPDRGMTFN 1811
Query: 446 LIGHSSAECILS--GNTAHWSMKPPICQQI----FCPNPPAILNGRHTGTPLGD--IPYG 497
LIG S+ C GN WS P C+ C P T P+ D P G
Sbjct: 1812 LIGESTIRCTSDPHGNGV-WSSPAPRCELSVRAGHCKTPEQFPFASPT-IPINDFEFPVG 1869
Query: 498 KEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
++Y C P G + S + N VWSS C
Sbjct: 1870 TSLNYECRP----GYFGKMFSISCLE-------NLVWSSVEDNC 1902
Score = 612 bits (1577), Expect = e-175
Identities = 302/529 (57%), Positives = 358/529 (67%), Gaps = 26/529 (4%)
Query: 28 LSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTSA 87
LS + C PE PFA PT +DFEFP+GT LNYECRPGY G+ FSI CL+N VW+S
Sbjct: 1839 LSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSV 1898
Query: 88 KDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWD 147
+D C+RKSC PP+P NGM H+ D QF S + YSC +G+RLIGS S TC++SGN V WD
Sbjct: 1899 EDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWD 1958
Query: 148 NKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYC 207
K P+C+ I C PPTI+NGDF S +R FH G+VVTY C+ G G+++FELVGE SIYC
Sbjct: 1959 KKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYC 2018
Query: 208 TSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGP 267
TSKDDQVG+WS P P+CI NKCT P VEN I V NRS F+L E++ FRCQPGF M G
Sbjct: 2019 TSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGS 2078
Query: 268 SHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGS 327
V+CQ +W P+LP CSRVCQPPP++LH E T +DNFSPGQEVFYSCEP YDLRG+
Sbjct: 2079 HTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGA 2138
Query: 328 TYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGS 387
LHCTPQGDWSP APRC VKSCDDFLGQLP+G VL PLNLQLGAKV FVCDEGF+LKG
Sbjct: 2139 ASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGR 2198
Query: 388 SASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVIT---DIHVGSRINYSCTT-- 442
SAS+CVLAGM++LWNSSVPVCE+ C PP +NG H T DI G I+Y+C T
Sbjct: 2199 SASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGR-HTGTPFGDIPYGKEISYACDTHP 2257
Query: 443 ----GHRLIGHSSAECIL--SGNTAHWSMKPPICQ---QIFCPNPPAILNGRHTGTPLGD 493
LIG SS C GN WS P C+ CP+PP I NG + G +
Sbjct: 2258 DRGMTFNLIGESSIRCTSDPQGNGV-WSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSL 2316
Query: 494 IPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542
G +SY CDP + L+G+ I T + G+WS C+
Sbjct: 2317 YLPGMTISYICDP------GYLLVGKGFIFCTDQ----GIWSQLDHYCK 2355
Score = 306 bits (783), Expect = 4e-83
Identities = 192/531 (36%), Positives = 270/531 (50%), Gaps = 52/531 (9%)
Query: 50 TDDFEFPIGTYLNYECRPGYS-GRPFSII------CLK----NSVWTSAKDKCKRK---- 94
T + P G ++Y C P G F++I C N VW+S +C+
Sbjct: 1785 TPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAG 1844
Query: 95 SCRNPPD-PVNGMAHVIKDIQFR--SQIKYSCPKGYRLIGSS-SATCIISGNTVIWDNKT 150
C+ P P I D +F + + Y C GY G S +C+ ++W +
Sbjct: 1845 HCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGY--FGKMFSISCL---ENLVWSSVE 1899
Query: 151 PVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSK 210
C R CG PP NG I+ + +GS V Y CN G F L+G PS C
Sbjct: 1900 DNCRRKSCGPPPEPFNG-MVHINTDT-QFGSTVNYSCNEG------FRLIGSPSTTCLVS 1951
Query: 211 DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPG------FGM 264
+ V W AP C I + PP + NG S+NR+ F VV ++C G F +
Sbjct: 1952 GNNV-TWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFEL 2010
Query: 265 KGPSHVKCQA----LNKWEPELPSCSRVCQ-PPPDVLHAERTQRDKDNFSPGQEVFYSCE 319
G + C + + W P C + P+V +A R ++ F+ + + + C+
Sbjct: 2011 VGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQ 2070
Query: 320 PGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPL-NLQLGAKVDFVC 378
PG+ + GS + C G W P P C + C L H L N G +V + C
Sbjct: 2071 PGFVMVGSHTVQCQTNGRWGPKLPHCS-RVCQPPPEILHGEHTLSHQDNFSPGQEVFYSC 2129
Query: 379 DEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCET--PPVPVNGMVHVITDIHVGSRI 436
+ + L+G+++ +C G W+ P C KSC+ +P +G V + ++ +G+++
Sbjct: 2130 EPSYDLRGAASLHCTPQGD---WSPEAPRCTVKSCDDFLGQLP-HGRVLLPLNLQLGAKV 2185
Query: 437 NYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPY 496
++ C G RL G S++ C+L+G A W+ P+C+QIFCPNPPAILNGRHTGTP GDIPY
Sbjct: 2186 SFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPY 2245
Query: 497 GKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVGA 547
GKE+SY CD HPDRGMTFNLIGES+IR TS+P GNGVWSSPAPRCEL V A
Sbjct: 2246 GKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPA 2296
Score = 296 bits (759), Expect = 3e-80
Identities = 196/551 (35%), Positives = 262/551 (47%), Gaps = 64/551 (11%)
Query: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYS-GRPFSII------CLK----NSV 83
C P +P R T + FP G +NY C P G F +I C N V
Sbjct: 1321 CPSPPVIPNGRHTGKPLEV-FPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGV 1379
Query: 84 WTSAKDKCKRKSCRNPPDPVNGMAHVI----------KDIQFRSQIKYSCPKGYRLIGSS 133
W+S +C PD H + D + +KY C Y G
Sbjct: 1380 WSSPAPRCGILGHCQAPD------HFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRP 1431
Query: 134 -SATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSR 192
S TC+ + ++W + VC R C PP NG I+ GS + Y C G R
Sbjct: 1432 FSITCL---DNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD--IQVGSRINYSCTTGHR 1486
Query: 193 GKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNE 252
L+G S C + WS P C PP + NG +S NR F
Sbjct: 1487 ------LIGHSSAECILSGNTAH-WSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGS 1539
Query: 253 VVEFRCQPG------FGMKGPSHVKCQA----LNKWEPELPSC--SRVCQPPPDVLHAER 300
VV +RC G F + G + C + + W P C C PP +V +
Sbjct: 1540 VVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP-NVENGIL 1598
Query: 301 TQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNG 360
++ FS + V + C+PG+ ++G + C W P P C + C L
Sbjct: 1599 VSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCS-RVCQPPPEILHGE 1657
Query: 361 HV-LFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCET--PP 417
H N G +V + C+ G+ L+G+++ +C G W+ P C KSC+
Sbjct: 1658 HTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPRCAVKSCDDFLGQ 1714
Query: 418 VPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPN 477
+P +G V ++ +G+++++ C G RL G S + C+L G + W+ P+C+ IFCPN
Sbjct: 1715 LP-HGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPN 1773
Query: 478 PPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSP 537
PPAILNGRHTGTP GDIPYGKE+SYTCDPHPDRGMTFNLIGESTIR TS+PHGNGVWSSP
Sbjct: 1774 PPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSP 1833
Query: 538 APRCELPVGAG 548
APRCEL V AG
Sbjct: 1834 APRCELSVRAG 1844
Score = 288 bits (736), Expect = 1e-77
Identities = 197/556 (35%), Positives = 268/556 (48%), Gaps = 82/556 (14%)
Query: 37 VPEWLPFARPTNLTDDF------EFPIGTYLNYECRPGYSGRPF-------SIICLKNS- 82
+P LP PT DF F G+ + Y C PG GR SI C N
Sbjct: 164 IPCGLP---PTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 220
Query: 83 ---VWTSAKDKCKRKSCRNPPDPVNGMAHVIKD----IQFRSQIKYSCPKGYRLIGSSSA 135
+W+ +C + PP+ NG+ ++ D +++ C G+ + G
Sbjct: 221 QVGIWSGPAPQCIIPNKCTPPNVENGI--LVSDNRSLFSLNEVVEFRCQPGFVMKGPRRV 278
Query: 136 TCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKK 195
C W+ + P C R+ C PP + + + T ++ F G V Y C G
Sbjct: 279 KCQALNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG----- 329
Query: 196 VFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN---- 251
++L G S+ CT + D WS AP C + + C + + + R LF +N
Sbjct: 330 -YDLRGAASMRCTPQGD----WSPAAPTCEVKS-CDDFMGQ----LLNGRVLFPVNLQLG 379
Query: 252 EVVEFRCQPGFGMKGPSHVKCQALNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDN 307
V+F C GF +KG S C W +P C ++ C PP + + T + +
Sbjct: 380 AKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEV 439
Query: 308 FSPGQEVFYSCEP------GYDLRGSTYLHCT--PQGD--WSPAAPRCEVKSCDDFLG-- 355
F G+ V Y+C+P +DL G + + CT PQG+ WS APRC + LG
Sbjct: 440 FPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGI------LGHC 493
Query: 356 QLPNGHVLFPLNLQ-------LGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 408
Q P+ + L Q +G + + C + G S L + +W+S VC
Sbjct: 494 QAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSITCLDNL--VWSSPKDVC 549
Query: 409 ERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPP 468
+RKSC+TPP PVNGMVHVITDI VGSRINYSCTTGHRLIGHSSAECILSGN AHWS KPP
Sbjct: 550 KRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPP 609
Query: 469 ICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEP 528
ICQ+I C PP I NG T + YG V+Y C+P F L+GE +I TS
Sbjct: 610 ICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSND 669
Query: 529 HGNGVWSSPAPRCELP 544
G+WS PAP+C +P
Sbjct: 670 DQVGIWSGPAPQCIIP 685
Score = 288 bits (736), Expect = 1e-77
Identities = 197/556 (35%), Positives = 268/556 (48%), Gaps = 82/556 (14%)
Query: 37 VPEWLPFARPTNLTDDF------EFPIGTYLNYECRPGYSGRPF-------SIICLKNS- 82
+P LP PT DF F G+ + Y C PG GR SI C N
Sbjct: 614 IPCGLP---PTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 670
Query: 83 ---VWTSAKDKCKRKSCRNPPDPVNGMAHVIKD----IQFRSQIKYSCPKGYRLIGSSSA 135
+W+ +C + PP+ NG+ ++ D +++ C G+ + G
Sbjct: 671 QVGIWSGPAPQCIIPNKCTPPNVENGI--LVSDNRSLFSLNEVVEFRCQPGFVMKGPRRV 728
Query: 136 TCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKK 195
C W+ + P C R+ C PP + + + T ++ F G V Y C G
Sbjct: 729 KCQALNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG----- 779
Query: 196 VFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN---- 251
++L G S+ CT + D WS AP C + + C + + + R LF +N
Sbjct: 780 -YDLRGAASMRCTPQGD----WSPAAPTCEVKS-CDDFMGQ----LLNGRVLFPVNLQLG 829
Query: 252 EVVEFRCQPGFGMKGPSHVKCQALNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDN 307
V+F C GF +KG S C W +P C ++ C PP + + T + +
Sbjct: 830 AKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEV 889
Query: 308 FSPGQEVFYSCEP------GYDLRGSTYLHCT--PQGD--WSPAAPRCEVKSCDDFLG-- 355
F G+ V Y+C+P +DL G + + CT PQG+ WS APRC + LG
Sbjct: 890 FPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGI------LGHC 943
Query: 356 QLPNGHVLFPLNLQ-------LGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 408
Q P+ + L Q +G + + C + G S L + +W+S VC
Sbjct: 944 QAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSITCLDNL--VWSSPKDVC 999
Query: 409 ERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPP 468
+RKSC+TPP PVNGMVHVITDI VGSRINYSCTTGHRLIGHSSAECILSGN AHWS KPP
Sbjct: 1000 KRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPP 1059
Query: 469 ICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEP 528
ICQ+I C PP I NG T + YG V+Y C+P F L+GE +I TS
Sbjct: 1060 ICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSND 1119
Query: 529 HGNGVWSSPAPRCELP 544
G+WS PAP+C +P
Sbjct: 1120 DQVGIWSGPAPQCIIP 1135
Score = 200 bits (508), Expect = 3e-51
Identities = 149/537 (27%), Positives = 238/537 (44%), Gaps = 42/537 (7%)
Query: 28 LSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGR-PFSIICLKNSVWTS 86
L S S C P + A T D F G + Y C PGY R S+ C W+
Sbjct: 740 LPSCSRVCQPPPDVLHAERTQRDKD-NFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 798
Query: 87 AKDKCKRKSCRN-PPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVI 145
A C+ KSC + +NG ++Q +++ + C +G++L GSS++ C+++G +
Sbjct: 799 AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL 858
Query: 146 WDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSI 205
W++ PVC++I C PP I NG T E F +G V Y C+ F+L+GE +I
Sbjct: 859 WNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTI 918
Query: 206 YCTSKDDQVGIWSGPAPQCIIPNKCTPPN--VENGILVSDNRSLFSLNEVVEFRCQPGFG 263
CTS G+WS PAP+C I C P+ + + N S F + +++ C+P +
Sbjct: 919 RCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY 978
Query: 264 MKGPSHVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY 322
+ P + C W C R C+ PPD ++ + G + YSC G+
Sbjct: 979 GR-PFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNG--MVHVITDIQVGSRINYSCTTGH 1035
Query: 323 DLRGSTYLHCTPQGD---WSPAAPRCEVKSCDDFLGQLPNGHVLFPL--NLQLGAKVDFV 377
L G + C G+ WS P C+ C + NG + N G+ V +
Sbjct: 1036 RLIGHSSAECILSGNAAHWSTKPPICQRIPCG-LPPTIANGDFISTNRENFHYGSVVTYR 1094
Query: 378 CDEG------FQLKGSSASYCVLAGME-SLWNSSVPVCERKSCETPPVPVNGMVHVITD- 429
C+ G F+L G + YC + +W+ P C + TPP NG++ ++D
Sbjct: 1095 CNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGIL--VSDN 1152
Query: 430 ---IHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRH 486
+ + + C G + G +C W + P C ++ C PP +L+
Sbjct: 1153 RSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK---WEPELPSCSRV-CQPPPDVLHAER 1208
Query: 487 TGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
T + G+EV Y+C+P ++L G +++R T + G WS AP CE+
Sbjct: 1209 TQRDKDNFSPGQEVFYSCEPG------YDLRGAASMRCTPQ----GDWSPAAPTCEV 1255
Score = 160 bits (404), Expect = 4e-39
Identities = 93/324 (28%), Positives = 147/324 (45%), Gaps = 6/324 (1%)
Query: 49 LTDDFEFPIGTYLNYECRPGYSGR-PFSIICLKNSVWTSAKDKCKRKSCRNPPDPV-NGM 106
L+ F G + Y C P Y R S+ C W+ +C KSC + + +G
Sbjct: 2113 LSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGR 2172
Query: 107 AHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIAN 166
+ ++Q +++ + C +G+RL G S++ C+++G +W++ PVC++I C PP I N
Sbjct: 2173 VLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILN 2232
Query: 167 GDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQC-- 224
G T YG ++Y C+ F L+GE SI CTS G+WS PAP+C
Sbjct: 2233 GRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCEL 2292
Query: 225 IIPNKCT-PPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELP 283
+P C PP ++NG + + SL+ + + C PG+ + G + C W
Sbjct: 2293 SVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDH 2352
Query: 284 SCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAA 342
C V C P + + K + G V CE GY L GS + C W P
Sbjct: 2353 YCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 2412
Query: 343 PRCEVKSCDDFLGQLPNGHVLFPL 366
+C ++ D + +G + F L
Sbjct: 2413 AKCTSRTHDALIVGTLSGTIFFIL 2436
Score = 154 bits (390), Expect = 2e-37
Identities = 76/175 (43%), Positives = 100/175 (57%), Gaps = 4/175 (2%)
Query: 370 LGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITD 429
+G +++ C G+ S + ++ S+W + C RKSC PP PVNGMVHVI
Sbjct: 65 IGTYLNYECRPGY----SGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKG 120
Query: 430 IHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGT 489
I GS+I YSCT G+RLIG SSA CI+SG+T W + PIC +I C PP I NG T
Sbjct: 121 IQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIST 180
Query: 490 PLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELP 544
+ YG V+Y C+P F L+GE +I TS G+WS PAP+C +P
Sbjct: 181 NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP 235
Score = 137 bits (344), Expect = 3e-32
Identities = 123/457 (26%), Positives = 196/457 (42%), Gaps = 75/457 (16%)
Query: 46 PTNLTDDF------EFPIGTYLNYECRPGYSGRPF-------SIICLKNS----VWTSAK 88
PT DF F GT + Y+C G G SI C VW+S
Sbjct: 1973 PTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPP 2032
Query: 89 DKCKRKSCRNPPD-------PVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISG 141
+C + P+ P N + +I I++ C G+ ++GS + C +G
Sbjct: 2033 PRCISTNKCTAPEVENAIRVPGNRSFFTLTEI-----IRFRCQPGFVMVGSHTVQCQTNG 2087
Query: 142 NTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVG 201
W K P C R+ C PP I +G+ T ++ F G V Y C + ++L G
Sbjct: 2088 R---WGPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFYSC------EPSYDLRG 2137
Query: 202 EPSIYCTSKDDQVGIWSGPAPQCIIPNKCTP--PNVENG-ILVSDNRSLFSLNEVVEFRC 258
S++CT + D WS AP+C + + C + +G +L+ N L V F C
Sbjct: 2138 AASLHCTPQGD----WSPEAPRCTVKS-CDDFLGQLPHGRVLLPLN---LQLGAKVSFVC 2189
Query: 259 QPGFGMKGPSHVKCQALNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEV 314
GF +KG S C W +P C ++ C PP +L+ T + G+E+
Sbjct: 2190 DEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEI 2249
Query: 315 FYSCEPG------YDLRGSTYLHCT--PQGD--WSPAAPRCE--VKSCDDFLGQLPNGHV 362
Y+C+ ++L G + + CT PQG+ WS APRCE V + ++ NGH
Sbjct: 2250 SYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHY 2309
Query: 363 LFP-LNLQL-GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPV 420
+ ++L L G + ++CD G+ L G +C G +W+ C+ +C P + +
Sbjct: 2310 IGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQG---IWSQLDHYCKEVNCSFP-LFM 2365
Query: 421 NGM---VHVITDIHVGSRINYSCTTGHRLIGHSSAEC 454
NG+ + + H G + C G+ L G ++C
Sbjct: 2366 NGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQC 2402
>gi|86793036 complement receptor 1 isoform F precursor [Homo
sapiens]
Length = 2039
Score = 778 bits (2009), Expect = 0.0
Identities = 391/539 (72%), Positives = 417/539 (77%), Gaps = 27/539 (5%)
Query: 18 GLLLAALVLLLSSFS-DQCNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSI 76
G LLA +VLL + QCN PEWLPFARPTNLTD+FEFPIGTYLNYECRPGYSGRPFSI
Sbjct: 25 GSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRPFSI 84
Query: 77 ICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSAT 136
ICLKNSVWT AKD+C+RKSCRNPPDPVNGM HVIK IQF SQIKYSC KGYRLIGSSSAT
Sbjct: 85 ICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSAT 144
Query: 137 CIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKV 196
CIISG+TVIWDN+TP+CDRI CGLPPTI NGDF S +RE FHYGSVVTY CN GS G+KV
Sbjct: 145 CIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKV 204
Query: 197 FELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 256
FELVGEPSIYCTS DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF
Sbjct: 205 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 264
Query: 257 RCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFY 316
RCQPGF MKGP VKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFY
Sbjct: 265 RCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFY 324
Query: 317 SCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDF 376
SCEPGYDLRG+ + CTPQGDWSPAAP CEVKSCDDF+GQL NG VLFP+NLQLGAKVDF
Sbjct: 325 SCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDF 384
Query: 377 VCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHV---G 433
VCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE+ C +PPV NG H + V G
Sbjct: 385 VCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFG 443
Query: 434 SRINYSCT------TGHRLIGHSSAECIL--SGNTAHWSMKPPICQQI-FCPNPPAILNG 484
+NY+C T LIG S+ C GN WS P C + C P L
Sbjct: 444 KTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFA 502
Query: 485 R-HTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542
+ T T D P G + Y C P G F++ N VWSSP C+
Sbjct: 503 KLKTQTNASDFPIGTSLKYECRPE-YYGRPFSITCLD----------NLVWSSPKDVCK 550
Score = 689 bits (1778), Expect = 0.0
Identities = 349/521 (66%), Positives = 377/521 (72%), Gaps = 26/521 (4%)
Query: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRK 94
C P+ FA+ T+ +FPIGT L YECRP Y GRPFSI CL N VW+S KD CKRK
Sbjct: 493 CQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRK 552
Query: 95 SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCD 154
SC+ PPDPVNGM HVI DIQ S+I YSC G+RLIG SSA CI+SGN W K P+C
Sbjct: 553 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
Query: 155 RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQV 214
RI CGLPPTIANGDF S +RE FHYGSVVTY CN GS G+KVFELVGEPSIYCTS DDQV
Sbjct: 613 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQV 672
Query: 215 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF MKGP VKCQA
Sbjct: 673 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 732
Query: 275 LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTP 334
LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG+ + CTP
Sbjct: 733 LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTP 792
Query: 335 QGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVL 394
QGDWSPAAP CEVKSCDDF+GQL NG VLFP+NLQLGAKVDFVCDEGFQLKGSSASYCVL
Sbjct: 793 QGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVL 852
Query: 395 AGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHV---GSRINYSCT------TGHR 445
AGMESLWNSSVPVCE+ C +PPV NG H + V G +NY+C T
Sbjct: 853 AGMESLWNSSVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKAVNYTCDPHPDRGTSFD 911
Query: 446 LIGHSSAECIL--SGNTAHWSMKPPICQQI-FCPNPPAILNGR-HTGTPLGDIPYGKEVS 501
LIG S+ C GN WS P C + C P L + T T D P G +
Sbjct: 912 LIGESTIRCTSDPQGNGV-WSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLK 970
Query: 502 YTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542
Y C P G F++ N VWSSP C+
Sbjct: 971 YECRPE-YYGRPFSITCLD----------NLVWSSPKDVCK 1000
Score = 667 bits (1722), Expect = 0.0
Identities = 338/524 (64%), Positives = 368/524 (70%), Gaps = 31/524 (5%)
Query: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRK 94
C P+ FA+ T+ +FPIGT L YECRP Y GRPFSI CL N VW+S KD CKRK
Sbjct: 943 CQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRK 1002
Query: 95 SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCD 154
SC+ PPDPVNGM HVI DIQ S+I YSC G+RLIG SSA CI+SGNT W K P+C
Sbjct: 1003 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1062
Query: 155 RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQV 214
RI CGLPPTIANGDF S +RE FHYGSVVTY CNLGSRG+KVFELVGEPSIYCTS DDQV
Sbjct: 1063 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQV 1122
Query: 215 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF MKGP VKCQA
Sbjct: 1123 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQA 1182
Query: 275 LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTP 334
LNKWEPELPSCSRVCQPPP++LH E T +DNFSPGQEVFYSCEPGYDLRG+ LHCTP
Sbjct: 1183 LNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTP 1242
Query: 335 QGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVL 394
QGDWSP APRC VKSCDDFLGQLP+G VLFPLNLQLGAKV FVCDEGF+LKGSS S+CVL
Sbjct: 1243 QGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVL 1302
Query: 395 AGMESLWNSSVPVCERKSCETPPVPVNGMVHVIT---DIHVGSRINYSCT------TGHR 445
GM SLWN+SVPVCE C PP +NG H T DI G I+Y+C
Sbjct: 1303 VGMRSLWNNSVPVCEHIFCPNPPAILNGR-HTGTPSGDIPYGKEISYTCDPHPDRGMTFN 1361
Query: 446 LIGHSSAECILS--GNTAHWSMKPPICQQI----FCPNPPAILNGRHTGTPLGD--IPYG 497
LIG S+ C GN WS P C+ C P T P+ D P G
Sbjct: 1362 LIGESTIRCTSDPHGNGV-WSSPAPRCELSVRAGHCKTPEQFPFASPT-IPINDFEFPVG 1419
Query: 498 KEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
++Y C P G + S + N VWSS C
Sbjct: 1420 TSLNYECRP----GYFGKMFSISCLE-------NLVWSSVEDNC 1452
Score = 612 bits (1577), Expect = e-175
Identities = 302/529 (57%), Positives = 358/529 (67%), Gaps = 26/529 (4%)
Query: 28 LSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTSA 87
LS + C PE PFA PT +DFEFP+GT LNYECRPGY G+ FSI CL+N VW+S
Sbjct: 1389 LSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSV 1448
Query: 88 KDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWD 147
+D C+RKSC PP+P NGM H+ D QF S + YSC +G+RLIGS S TC++SGN V WD
Sbjct: 1449 EDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWD 1508
Query: 148 NKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYC 207
K P+C+ I C PPTI+NGDF S +R FH G+VVTY C+ G G+++FELVGE SIYC
Sbjct: 1509 KKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYC 1568
Query: 208 TSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGP 267
TSKDDQVG+WS P P+CI NKCT P VEN I V NRS F+L E++ FRCQPGF M G
Sbjct: 1569 TSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGS 1628
Query: 268 SHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGS 327
V+CQ +W P+LP CSRVCQPPP++LH E T +DNFSPGQEVFYSCEP YDLRG+
Sbjct: 1629 HTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGA 1688
Query: 328 TYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGS 387
LHCTPQGDWSP APRC VKSCDDFLGQLP+G VL PLNLQLGAKV FVCDEGF+LKG
Sbjct: 1689 ASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGR 1748
Query: 388 SASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVIT---DIHVGSRINYSCTT-- 442
SAS+CVLAGM++LWNSSVPVCE+ C PP +NG H T DI G I+Y+C T
Sbjct: 1749 SASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGR-HTGTPFGDIPYGKEISYACDTHP 1807
Query: 443 ----GHRLIGHSSAECIL--SGNTAHWSMKPPICQ---QIFCPNPPAILNGRHTGTPLGD 493
LIG SS C GN WS P C+ CP+PP I NG + G +
Sbjct: 1808 DRGMTFNLIGESSIRCTSDPQGNGV-WSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSL 1866
Query: 494 IPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542
G +SY CDP + L+G+ I T + G+WS C+
Sbjct: 1867 YLPGMTISYICDP------GYLLVGKGFIFCTDQ----GIWSQLDHYCK 1905
Score = 306 bits (783), Expect = 4e-83
Identities = 192/531 (36%), Positives = 270/531 (50%), Gaps = 52/531 (9%)
Query: 50 TDDFEFPIGTYLNYECRPGYS-GRPFSII------CLK----NSVWTSAKDKCKRK---- 94
T + P G ++Y C P G F++I C N VW+S +C+
Sbjct: 1335 TPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAG 1394
Query: 95 SCRNPPD-PVNGMAHVIKDIQFR--SQIKYSCPKGYRLIGSS-SATCIISGNTVIWDNKT 150
C+ P P I D +F + + Y C GY G S +C+ ++W +
Sbjct: 1395 HCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGY--FGKMFSISCL---ENLVWSSVE 1449
Query: 151 PVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSK 210
C R CG PP NG I+ + +GS V Y CN G F L+G PS C
Sbjct: 1450 DNCRRKSCGPPPEPFNG-MVHINTDT-QFGSTVNYSCNEG------FRLIGSPSTTCLVS 1501
Query: 211 DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPG------FGM 264
+ V W AP C I + PP + NG S+NR+ F VV ++C G F +
Sbjct: 1502 GNNV-TWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFEL 1560
Query: 265 KGPSHVKCQA----LNKWEPELPSCSRVCQ-PPPDVLHAERTQRDKDNFSPGQEVFYSCE 319
G + C + + W P C + P+V +A R ++ F+ + + + C+
Sbjct: 1561 VGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQ 1620
Query: 320 PGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPL-NLQLGAKVDFVC 378
PG+ + GS + C G W P P C + C L H L N G +V + C
Sbjct: 1621 PGFVMVGSHTVQCQTNGRWGPKLPHCS-RVCQPPPEILHGEHTLSHQDNFSPGQEVFYSC 1679
Query: 379 DEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCET--PPVPVNGMVHVITDIHVGSRI 436
+ + L+G+++ +C G W+ P C KSC+ +P +G V + ++ +G+++
Sbjct: 1680 EPSYDLRGAASLHCTPQGD---WSPEAPRCTVKSCDDFLGQLP-HGRVLLPLNLQLGAKV 1735
Query: 437 NYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPY 496
++ C G RL G S++ C+L+G A W+ P+C+QIFCPNPPAILNGRHTGTP GDIPY
Sbjct: 1736 SFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPY 1795
Query: 497 GKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVGA 547
GKE+SY CD HPDRGMTFNLIGES+IR TS+P GNGVWSSPAPRCEL V A
Sbjct: 1796 GKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPA 1846
Score = 296 bits (759), Expect = 3e-80
Identities = 196/551 (35%), Positives = 262/551 (47%), Gaps = 64/551 (11%)
Query: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYS-GRPFSII------CLK----NSV 83
C P +P R T + FP G +NY C P G F +I C N V
Sbjct: 871 CPSPPVIPNGRHTGKPLEV-FPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGV 929
Query: 84 WTSAKDKCKRKSCRNPPDPVNGMAHVI----------KDIQFRSQIKYSCPKGYRLIGSS 133
W+S +C PD H + D + +KY C Y G
Sbjct: 930 WSSPAPRCGILGHCQAPD------HFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRP 981
Query: 134 -SATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSR 192
S TC+ + ++W + VC R C PP NG I+ GS + Y C G R
Sbjct: 982 FSITCL---DNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD--IQVGSRINYSCTTGHR 1036
Query: 193 GKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNE 252
L+G S C + WS P C PP + NG +S NR F
Sbjct: 1037 ------LIGHSSAECILSGNTAH-WSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGS 1089
Query: 253 VVEFRCQPG------FGMKGPSHVKCQA----LNKWEPELPSC--SRVCQPPPDVLHAER 300
VV +RC G F + G + C + + W P C C PP +V +
Sbjct: 1090 VVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP-NVENGIL 1148
Query: 301 TQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNG 360
++ FS + V + C+PG+ ++G + C W P P C + C L
Sbjct: 1149 VSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCS-RVCQPPPEILHGE 1207
Query: 361 HV-LFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCET--PP 417
H N G +V + C+ G+ L+G+++ +C G W+ P C KSC+
Sbjct: 1208 HTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD---WSPEAPRCAVKSCDDFLGQ 1264
Query: 418 VPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPN 477
+P +G V ++ +G+++++ C G RL G S + C+L G + W+ P+C+ IFCPN
Sbjct: 1265 LP-HGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPN 1323
Query: 478 PPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSP 537
PPAILNGRHTGTP GDIPYGKE+SYTCDPHPDRGMTFNLIGESTIR TS+PHGNGVWSSP
Sbjct: 1324 PPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSP 1383
Query: 538 APRCELPVGAG 548
APRCEL V AG
Sbjct: 1384 APRCELSVRAG 1394
Score = 288 bits (736), Expect = 1e-77
Identities = 197/556 (35%), Positives = 268/556 (48%), Gaps = 82/556 (14%)
Query: 37 VPEWLPFARPTNLTDDF------EFPIGTYLNYECRPGYSGRPF-------SIICLKNS- 82
+P LP PT DF F G+ + Y C PG GR SI C N
Sbjct: 164 IPCGLP---PTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 220
Query: 83 ---VWTSAKDKCKRKSCRNPPDPVNGMAHVIKD----IQFRSQIKYSCPKGYRLIGSSSA 135
+W+ +C + PP+ NG+ ++ D +++ C G+ + G
Sbjct: 221 QVGIWSGPAPQCIIPNKCTPPNVENGI--LVSDNRSLFSLNEVVEFRCQPGFVMKGPRRV 278
Query: 136 TCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKK 195
C W+ + P C R+ C PP + + + T ++ F G V Y C G
Sbjct: 279 KCQALNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG----- 329
Query: 196 VFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLN---- 251
++L G S+ CT + D WS AP C + + C + + + R LF +N
Sbjct: 330 -YDLRGAASMRCTPQGD----WSPAAPTCEVKS-CDDFMGQ----LLNGRVLFPVNLQLG 379
Query: 252 EVVEFRCQPGFGMKGPSHVKCQALNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDN 307
V+F C GF +KG S C W +P C ++ C PP + + T + +
Sbjct: 380 AKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEV 439
Query: 308 FSPGQEVFYSCEP------GYDLRGSTYLHCT--PQGD--WSPAAPRCEVKSCDDFLG-- 355
F G+ V Y+C+P +DL G + + CT PQG+ WS APRC + LG
Sbjct: 440 FPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGI------LGHC 493
Query: 356 QLPNGHVLFPLNLQ-------LGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 408
Q P+ + L Q +G + + C + G S L + +W+S VC
Sbjct: 494 QAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSITCLDNL--VWSSPKDVC 549
Query: 409 ERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPP 468
+RKSC+TPP PVNGMVHVITDI VGSRINYSCTTGHRLIGHSSAECILSGN AHWS KPP
Sbjct: 550 KRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPP 609
Query: 469 ICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEP 528
ICQ+I C PP I NG T + YG V+Y C+P F L+GE +I TS
Sbjct: 610 ICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSND 669
Query: 529 HGNGVWSSPAPRCELP 544
G+WS PAP+C +P
Sbjct: 670 DQVGIWSGPAPQCIIP 685
Score = 200 bits (508), Expect = 3e-51
Identities = 149/537 (27%), Positives = 238/537 (44%), Gaps = 42/537 (7%)
Query: 28 LSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGR-PFSIICLKNSVWTS 86
L S S C P + A T D F G + Y C PGY R S+ C W+
Sbjct: 290 LPSCSRVCQPPPDVLHAERTQRDKD-NFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 348
Query: 87 AKDKCKRKSCRN-PPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVI 145
A C+ KSC + +NG ++Q +++ + C +G++L GSS++ C+++G +
Sbjct: 349 AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL 408
Query: 146 WDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSI 205
W++ PVC++I C PP I NG T E F +G V Y C+ F+L+GE +I
Sbjct: 409 WNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTI 468
Query: 206 YCTSKDDQVGIWSGPAPQCIIPNKCTPPN--VENGILVSDNRSLFSLNEVVEFRCQPGFG 263
CTS G+WS PAP+C I C P+ + + N S F + +++ C+P +
Sbjct: 469 RCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY 528
Query: 264 MKGPSHVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY 322
+ P + C W C R C+ PPD ++ + G + YSC G+
Sbjct: 529 GR-PFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNG--MVHVITDIQVGSRINYSCTTGH 585
Query: 323 DLRGSTYLHCTPQGD---WSPAAPRCEVKSCDDFLGQLPNGHVLFPL--NLQLGAKVDFV 377
L G + C G+ WS P C+ C + NG + N G+ V +
Sbjct: 586 RLIGHSSAECILSGNAAHWSTKPPICQRIPCG-LPPTIANGDFISTNRENFHYGSVVTYR 644
Query: 378 CDEG------FQLKGSSASYCVLAGME-SLWNSSVPVCERKSCETPPVPVNGMVHVITD- 429
C+ G F+L G + YC + +W+ P C + TPP NG++ ++D
Sbjct: 645 CNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGIL--VSDN 702
Query: 430 ---IHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRH 486
+ + + C G + G +C W + P C ++ C PP +L+
Sbjct: 703 RSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK---WEPELPSCSRV-CQPPPDVLHAER 758
Query: 487 TGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
T + G+EV Y+C+P ++L G +++R T + G WS AP CE+
Sbjct: 759 TQRDKDNFSPGQEVFYSCEPG------YDLRGAASMRCTPQ----GDWSPAAPTCEV 805
Score = 160 bits (404), Expect = 4e-39
Identities = 93/324 (28%), Positives = 147/324 (45%), Gaps = 6/324 (1%)
Query: 49 LTDDFEFPIGTYLNYECRPGYSGR-PFSIICLKNSVWTSAKDKCKRKSCRNPPDPV-NGM 106
L+ F G + Y C P Y R S+ C W+ +C KSC + + +G
Sbjct: 1663 LSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGR 1722
Query: 107 AHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIAN 166
+ ++Q +++ + C +G+RL G S++ C+++G +W++ PVC++I C PP I N
Sbjct: 1723 VLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILN 1782
Query: 167 GDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQC-- 224
G T YG ++Y C+ F L+GE SI CTS G+WS PAP+C
Sbjct: 1783 GRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCEL 1842
Query: 225 IIPNKCT-PPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELP 283
+P C PP ++NG + + SL+ + + C PG+ + G + C W
Sbjct: 1843 SVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDH 1902
Query: 284 SCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAA 342
C V C P + + K + G V CE GY L GS + C W P
Sbjct: 1903 YCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL 1962
Query: 343 PRCEVKSCDDFLGQLPNGHVLFPL 366
+C ++ D + +G + F L
Sbjct: 1963 AKCTSRTHDALIVGTLSGTIFFIL 1986
Score = 154 bits (390), Expect = 2e-37
Identities = 76/175 (43%), Positives = 100/175 (57%), Gaps = 4/175 (2%)
Query: 370 LGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITD 429
+G +++ C G+ S + ++ S+W + C RKSC PP PVNGMVHVI
Sbjct: 65 IGTYLNYECRPGY----SGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKG 120
Query: 430 IHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGT 489
I GS+I YSCT G+RLIG SSA CI+SG+T W + PIC +I C PP I NG T
Sbjct: 121 IQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIST 180
Query: 490 PLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELP 544
+ YG V+Y C+P F L+GE +I TS G+WS PAP+C +P
Sbjct: 181 NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIP 235
Score = 137 bits (344), Expect = 3e-32
Identities = 123/457 (26%), Positives = 196/457 (42%), Gaps = 75/457 (16%)
Query: 46 PTNLTDDF------EFPIGTYLNYECRPGYSGRPF-------SIICLKNS----VWTSAK 88
PT DF F GT + Y+C G G SI C VW+S
Sbjct: 1523 PTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPP 1582
Query: 89 DKCKRKSCRNPPD-------PVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISG 141
+C + P+ P N + +I I++ C G+ ++GS + C +G
Sbjct: 1583 PRCISTNKCTAPEVENAIRVPGNRSFFTLTEI-----IRFRCQPGFVMVGSHTVQCQTNG 1637
Query: 142 NTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVG 201
W K P C R+ C PP I +G+ T ++ F G V Y C + ++L G
Sbjct: 1638 R---WGPKLPHCSRV-CQPPPEILHGEHTLSHQDNFSPGQEVFYSC------EPSYDLRG 1687
Query: 202 EPSIYCTSKDDQVGIWSGPAPQCIIPNKCTP--PNVENG-ILVSDNRSLFSLNEVVEFRC 258
S++CT + D WS AP+C + + C + +G +L+ N L V F C
Sbjct: 1688 AASLHCTPQGD----WSPEAPRCTVKS-CDDFLGQLPHGRVLLPLN---LQLGAKVSFVC 1739
Query: 259 QPGFGMKGPSHVKCQALNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEV 314
GF +KG S C W +P C ++ C PP +L+ T + G+E+
Sbjct: 1740 DEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEI 1799
Query: 315 FYSCEPG------YDLRGSTYLHCT--PQGD--WSPAAPRCE--VKSCDDFLGQLPNGHV 362
Y+C+ ++L G + + CT PQG+ WS APRCE V + ++ NGH
Sbjct: 1800 SYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHY 1859
Query: 363 LFP-LNLQL-GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPV 420
+ ++L L G + ++CD G+ L G +C G +W+ C+ +C P + +
Sbjct: 1860 IGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQG---IWSQLDHYCKEVNCSFP-LFM 1915
Query: 421 NGM---VHVITDIHVGSRINYSCTTGHRLIGHSSAEC 454
NG+ + + H G + C G+ L G ++C
Sbjct: 1916 NGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQC 1952
>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
isoform 1 [Homo sapiens]
Length = 1092
Score = 269 bits (687), Expect = 6e-72
Identities = 175/509 (34%), Positives = 240/509 (47%), Gaps = 57/509 (11%)
Query: 55 FPIGTYLNYECRPGYS--GRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIK- 111
F GT + Y C PGY G SI C VWT +CK +C G + K
Sbjct: 429 FDPGTSIKYSCNPGYVLVGEE-SIQCTSEGVWTPPVPQCKVAACE-----ATGRQLLTKP 482
Query: 112 DIQF-RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFT 170
QF R + SC +GY+L GS C T+ W + +C I C PP I NG T
Sbjct: 483 QHQFVRPDVNSSCGEGYKLSGSVYQEC---QGTIPWFMEIRLCKEITCPPPPVIYNGAHT 539
Query: 171 SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQC---IIP 227
S E F YG+ VTY CN G F L+GE +I CTS D + G WSGPAP C ++
Sbjct: 540 GSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLA 599
Query: 228 NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSR 287
+C+ ++ NG +S + + N+ V F+C GF +KG S ++C+A N W+PE+P C +
Sbjct: 600 VQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEK 659
Query: 288 VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEV 347
CQ PP + H T + F G V Y+C+PGY L G+ +HC P G+WSP+APRCE
Sbjct: 660 GCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCE- 718
Query: 348 KSCDDFLGQLPNGHVLFPLNLQLGAKVDFV---CDEGFQLKGSSASYCVLAGMESLWNSS 404
++C L L G++V+ V C +G+QL G + C A +W
Sbjct: 719 ETCQHVRQSLQ--------ELPAGSRVELVNTSCQDGYQLTGHAYQMCQDA-ENGIWFKK 769
Query: 405 VPVCERKSCETPPVPVNG--MVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAH 462
+P+C+ C PPV VNG + + G+ ++Y C G L+G +C S + H
Sbjct: 770 IPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQC-RSDSKGH 828
Query: 463 --WSMKPPICQQ----IFCPNPPA----ILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGM 512
WS P C + CPNP LN H+ DI Y C+P
Sbjct: 829 GSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVY-----VDCNP------ 877
Query: 513 TFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
F + G IR H + W P C
Sbjct: 878 GFIMNGSRVIR----CHTDNTWVPGVPTC 902
Score = 248 bits (634), Expect = 8e-66
Identities = 156/503 (31%), Positives = 227/503 (45%), Gaps = 38/503 (7%)
Query: 58 GTYLNYECRPGYSGRPFSII-CLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFR 116
G + Y C GY II CL + W++ C+ C++ NG ++
Sbjct: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVG 235
Query: 117 SQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREY 176
+ C +GYRL G S+ C+I+G V W K PVC+ I C PP I NG S
Sbjct: 236 VTANFFCDEGYRLQGPPSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLAN 294
Query: 177 FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPN---KCTPP 233
YGS+VTY C+ F L+GE ++ CT + G WSGPAP+C + +C P
Sbjct: 295 VSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHP 354
Query: 234 NVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPP 293
+ G +VS + ++ N+ V F C GF +KG ++C A WEP P C + CQ PP
Sbjct: 355 QILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPP 414
Query: 294 DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDF 353
++L+ ++ R F PG + YSC PGY L G + CT +G W+P P+C+V +C+
Sbjct: 415 NILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEAT 474
Query: 354 LGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSC 413
QL + P + + V+ C EG++L GS C W + +C+ +C
Sbjct: 475 GRQL----LTKPQHQFVRPDVNSSCGEGYKLSGSVYQEC---QGTIPWFMEIRLCKEITC 527
Query: 414 ETPPVPVNGMVHV---ITDIHVGSRINYSCTTG------HRLIGHSSAECILSG-NTAHW 463
PPV NG H + D G+ + Y+C G LIG S+ C + W
Sbjct: 528 PPPPVIYNG-AHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTW 586
Query: 464 SMKPPICQ----QIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGE 519
S P+C+ + C + I NG Y V++ C F L G
Sbjct: 587 SGPAPLCKLSLLAVQCSH-VHIANGYKISGKEAPYFYNDTVTFKC------YSGFTLKGS 639
Query: 520 STIRRTSEPHGNGVWSSPAPRCE 542
S IR ++ W P CE
Sbjct: 640 SQIRCKAD----NTWDPEIPVCE 658
Score = 216 bits (551), Expect = 3e-56
Identities = 146/467 (31%), Positives = 205/467 (43%), Gaps = 48/467 (10%)
Query: 119 IKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFH 178
+ YSC GY L+G C+ SG W P C+ C NG
Sbjct: 179 VTYSCESGYLLVGEKIINCLSSGK---WSAVPPTCEEARCKSLGRFPNGKVKE--PPILR 233
Query: 179 YGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENG 238
G + C+ G R L G PS C V W+ P C +PP + NG
Sbjct: 234 VGVTANFFCDEGYR------LQGPPSSRCVIAGQGVA-WT-KMPVCEEIFCPSPPPILNG 285
Query: 239 ILVSDNRSLFSLNEVVEFRCQP------GFGMKGPSHVKC----QALNKWEPELPSC--- 285
+ ++ + S +V + C P F + G S ++C Q W P C
Sbjct: 286 RHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELS 345
Query: 286 -SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPR 344
S V P P +L KD ++ V ++C G+ L+GS + C QG W P+AP
Sbjct: 346 TSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPV 405
Query: 345 CEVKSCDD----FLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL 400
CE K C GQ + H++ G + + C+ G+ L G + C E +
Sbjct: 406 CE-KECQAPPNILNGQKEDRHMV---RFDPGTSIKYSCNPGYVLVGEESIQCT---SEGV 458
Query: 401 WNSSVPVCERKSCETPPVPVNGMVHVITDIH--VGSRINYSCTTGHRLIGHSSAECILSG 458
W VP C+ +CE G + H V +N SC G++L G EC
Sbjct: 459 WTPPVPQCKVAACEA-----TGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQEC---Q 510
Query: 459 NTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIG 518
T W M+ +C++I CP PP I NG HTG+ L D PYG V+YTC+P P+RG+ F+LIG
Sbjct: 511 GTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIG 570
Query: 519 ESTIRRTSEPHGNGVWSSPAPRCELPVGAGSHDALIVGKFYEVFAEE 565
ESTIR TS G WS PAP C+L + A + + Y++ +E
Sbjct: 571 ESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKE 617
Score = 205 bits (521), Expect = 1e-52
Identities = 139/408 (34%), Positives = 189/408 (46%), Gaps = 42/408 (10%)
Query: 156 IICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVG 215
I CG PP I NG + S G+V+ Y C+ F L+GE S+ C +KD G
Sbjct: 21 ISCGSPPPILNGRISYYSTP-IAVGTVIRYSCS------GTFRLIGEKSLLCITKDKVDG 73
Query: 216 IWSGPAPQCIIPNK---CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKC 272
W PAP+C NK C P V G + + + + + V F C+ F M G V C
Sbjct: 74 TWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGS-TPYRHGDSVTFACKTNFSMNGNKSVWC 132
Query: 273 QALNKWEP-ELPSCSRV----CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGS 327
QA N W P LP+C V C P + + T + + +PG V YSCE GY L G
Sbjct: 133 QANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGE 192
Query: 328 TYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGS 387
++C G WS P CE C LG+ PNG V P L++G +F CDEG++L+G
Sbjct: 193 KIINCLSSGKWSAVPPTCEEARCKS-LGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251
Query: 388 SASYCVLAGMESLWNSSVPVCERKSCETPPVPVNG--MVHVITDIHVGSRINYSCT---- 441
+S CV+AG W + +PVCE C +PP +NG + + + ++ GS + Y+C
Sbjct: 252 PSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPE 310
Query: 442 --TGHRLIGHSSAECIL-SGNTAHWSMKPPICQ----QIFCPNPPAILNGRHTGTPLGDI 494
LIG S+ C + S T WS P C+ + CP+ P IL GR
Sbjct: 311 EGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPH-PQILRGRMVSGQKDRY 369
Query: 495 PYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542
Y V + C F L G IR ++ G W AP CE
Sbjct: 370 TYNDTVIFAC------MFGFTLKGSKQIRCNAQ----GTWEPSAPVCE 407
Score = 202 bits (513), Expect = 9e-52
Identities = 128/391 (32%), Positives = 188/391 (48%), Gaps = 33/391 (8%)
Query: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYS--GRPFSIICLKNSVWTSAKDKCK 92
C P L R T F F G ++Y C PGY G SI C+ + W+ + +C+
Sbjct: 661 CQSPPGLHHGRHTGGNTVF-FVSGMTVDYTCDPGYLLVGNK-SIHCMPSGNWSPSAPRCE 718
Query: 93 RKSCRNPPDPVNGMAHVIKDIQFRSQIKY---SCPKGYRLIGSSSATCIISGNTVIWDNK 149
++C++ + ++++ S+++ SC GY+L G + C + N IW K
Sbjct: 719 -ETCQH-------VRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENG-IWFKK 769
Query: 150 TPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTS 209
P+C I C PP I NG T + E F YG+ V+Y C+ G F L+GE + C S
Sbjct: 770 IPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQG------FYLLGEKKLQCRS 823
Query: 210 KDDQVGIWSGPAPQCIIP---NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKG 266
G WSGP+PQC+ +C P V++G ++ S +S N++V C PGF M G
Sbjct: 824 DSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNG 883
Query: 267 PSHVKCQALNKWEPELPSCSRV----CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY 322
++C N W P +P+C + C PPP + T + FSPG + YSC+ GY
Sbjct: 884 SRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGY 943
Query: 323 DLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNL-QLGAKVDFVCDEG 381
L G L CT +G WS AP C+ +C L P + Q GA V C++G
Sbjct: 944 LLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDG 1003
Query: 382 FQLKGSSASYCVLAGMESLWNSSVPVCERKS 412
+ L+GS S C + WN + VC +S
Sbjct: 1004 YMLEGSPQSQC---QSDHQWNPPLAVCRSRS 1031
Score = 181 bits (458), Expect = 2e-45
Identities = 105/330 (31%), Positives = 160/330 (48%), Gaps = 19/330 (5%)
Query: 231 TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNK----WEPELPSC- 285
+PP + NG +S + ++ V+ + C F + G + C +K W+ P C
Sbjct: 25 SPPPILNG-RISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCE 83
Query: 286 --SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAA- 342
++ P ++ R + G V ++C+ + + G+ + C W P
Sbjct: 84 YFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRL 143
Query: 343 PRCEVK---SCDDFLGQLPNGHVLFPL--NLQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397
P C C L + NGH ++ G V + C+ G+ L G C+ +G
Sbjct: 144 PTCVSVFPLECPA-LPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK 202
Query: 398 ESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILS 457
W++ P CE C++ NG V + VG N+ C G+RL G S+ C+++
Sbjct: 203 ---WSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIA 259
Query: 458 GNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLI 517
G W+ K P+C++IFCP+PP ILNGRH G L ++ YG V+YTCDP P+ G+ F LI
Sbjct: 260 GQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILI 318
Query: 518 GESTIRRTSEPHGNGVWSSPAPRCELPVGA 547
GEST+R T + G WS PAPRCEL A
Sbjct: 319 GESTLRCTVDSQKTGTWSGPAPRCELSTSA 348
Score = 151 bits (382), Expect = 1e-36
Identities = 141/488 (28%), Positives = 204/488 (41%), Gaps = 67/488 (13%)
Query: 54 EFPIGTYLNYECRPG-YSGRPFSII------CLKN----SVWTSAKDKCKRKSCRNPPDP 102
+FP GT + Y C PG G FS+I C N W+ CK
Sbjct: 545 DFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH 604
Query: 103 V---NGMAHVIKDIQ--FRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRII 157
V NG K+ + + + C G+ L GSS C + NT WD + PVC++
Sbjct: 605 VHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRC-KADNT--WDPEIPVCEK-G 660
Query: 158 CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217
C PP + +G T + +F G V Y C+ G + LVG SI+C G W
Sbjct: 661 CQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPG------YLLVGNKSIHCMPS----GNW 710
Query: 218 SGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNK 277
S AP+C C L + +R E+V CQ G+ + G ++ CQ
Sbjct: 711 SPSAPRC--EETCQHVRQSLQELPAGSRV-----ELVNTSCQDGYQLTGHAYQMCQDAEN 763
Query: 278 --WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTP 334
W ++P C + C PPP +++ + T +NF G EV Y C+ G+ L G L C
Sbjct: 764 GIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRS 823
Query: 335 ----QGDWSPAAPRC----EVKSCDDFLGQLPNGHVLFPLNLQLGAK--VDFVCDEGFQL 384
G WS +P+C V C + ++ +G+ L + V C+ GF +
Sbjct: 824 DSKGHGSWSGPSPQCLRSPPVTRCPN--PEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIM 881
Query: 385 KGSSASYCVLAGMESLWNSSVPVCERKS---CETPPVPVNGMVHV---ITDIHVGSRINY 438
GS C ++ W VP C +K+ C PP NG H I G I Y
Sbjct: 882 NGSRVIRC---HTDNTWVPGVPTCIKKAFIGCPPPPKTPNGN-HTGGNIARFSPGMSILY 937
Query: 439 SCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTG-TPLGDIPYG 497
SC G+ L+G + C G WS P C+++ C + PA ++G G P YG
Sbjct: 938 SCDQGYLLVGEALLLCTHEGT---WSQPAPHCKEVNC-SSPADMDGIQKGLEPRKMYQYG 993
Query: 498 KEVSYTCD 505
V+ C+
Sbjct: 994 AVVTLECE 1001
Score = 138 bits (347), Expect = 2e-32
Identities = 126/475 (26%), Positives = 196/475 (41%), Gaps = 54/475 (11%)
Query: 95 SCRNPPDPVNG-MAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNT-VIWDNKTPV 152
SC +PP +NG +++ I + I+YSC +RLIG S CI WD P
Sbjct: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
Query: 153 CDRI--ICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSK 210
C+ P I G + + +G VT+ C K F + G S++C +
Sbjct: 82 CEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFAC------KTNFSMNGNKSVWCQAN 135
Query: 211 DDQVGIWSGPA--PQC--IIPNKCTP-PNVENGILVSDNRSLFSLNEVVEFRCQPGFGMK 265
+ +W GP P C + P +C P + NG S+N + V + C+ G+ +
Sbjct: 136 N----MW-GPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLV 190
Query: 266 GPSHVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDL 324
G + C + KW P+C C+ + + ++ G + C+ GY L
Sbjct: 191 GEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGK--VKEPPILRVGVTANFFCDEGYRL 248
Query: 325 RGSTYLHCTPQGD---WSPAAPRCEVKSCDDFLGQLPNGHVLFPL-NLQLGAKVDFVCD- 379
+G C G W+ P CE C L H+ L N+ G+ V + CD
Sbjct: 249 QGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDP 307
Query: 380 ---EG--FQLKGSSASYCVLAGMES-LWNSSVPVCERKS----CETPPVPVNGMVHVITD 429
EG F L G S C + ++ W+ P CE + C P + MV D
Sbjct: 308 DPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKD 367
Query: 430 IHV-GSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTG 488
+ + ++C G L G C G W P+C++ C PP ILNG+
Sbjct: 368 RYTYNDTVIFACMFGFTLKGSKQIRCNAQGT---WEPSAPVCEK-ECQAPPNILNGQKED 423
Query: 489 TPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
+ G + Y+C+P + L+GE +I+ TSE GVW+ P P+C++
Sbjct: 424 RHMVRFDPGTSIKYSCNP------GYVLVGEESIQCTSE----GVWTPPVPQCKV 468
Score = 92.0 bits (227), Expect = 1e-18
Identities = 79/326 (24%), Positives = 125/326 (38%), Gaps = 26/326 (7%)
Query: 54 EFPIGT---YLNYECRPGY--SGRPFSIIC-LKNSVWTSAKDKCKRKSCRNPPDPVNGM- 106
E P G+ +N C+ GY +G + + +N +W CK C PP VNG
Sbjct: 730 ELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKH 789
Query: 107 -AHVIKDIQFRSQIKYSCPKGYRLIGSSSATCII-SGNTVIWDNKTPVCDRI--ICGLP- 161
+ ++ + +++ Y C +G+ L+G C S W +P C R + P
Sbjct: 790 TGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPN 849
Query: 162 PTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPA 221
P + +G + + + + +V CN G F + G I C + + W
Sbjct: 850 PEVKHGYKLNKTHSAYSHNDIVYVDCNPG------FIMNGSRVIRCHTDNT----WVPGV 899
Query: 222 PQCI---IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKW 278
P CI PP NG N + FS + + C G+ + G + + C W
Sbjct: 900 PTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTW 959
Query: 279 EPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGD 337
P C V C P D+ ++ + + G V CE GY L GS C
Sbjct: 960 SQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQ 1019
Query: 338 WSPAAPRCEVKSCDDFLGQLPNGHVL 363
W+P C +S L + G +L
Sbjct: 1020 WNPPLAVCRSRSLAPVLCGIAAGLIL 1045
>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
isoform 2 [Homo sapiens]
Length = 1033
Score = 248 bits (634), Expect = 8e-66
Identities = 156/503 (31%), Positives = 227/503 (45%), Gaps = 38/503 (7%)
Query: 58 GTYLNYECRPGYSGRPFSII-CLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFR 116
G + Y C GY II CL + W++ C+ C++ NG ++
Sbjct: 176 GLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVG 235
Query: 117 SQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREY 176
+ C +GYRL G S+ C+I+G V W K PVC+ I C PP I NG S
Sbjct: 236 VTANFFCDEGYRLQGPPSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLAN 294
Query: 177 FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPN---KCTPP 233
YGS+VTY C+ F L+GE ++ CT + G WSGPAP+C + +C P
Sbjct: 295 VSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHP 354
Query: 234 NVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPP 293
+ G +VS + ++ N+ V F C GF +KG ++C A WEP P C + CQ PP
Sbjct: 355 QILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPP 414
Query: 294 DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDF 353
++L+ ++ R F PG + YSC PGY L G + CT +G W+P P+C+V +C+
Sbjct: 415 NILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEAT 474
Query: 354 LGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSC 413
QL + P + + V+ C EG++L GS C W + +C+ +C
Sbjct: 475 GRQL----LTKPQHQFVRPDVNSSCGEGYKLSGSVYQEC---QGTIPWFMEIRLCKEITC 527
Query: 414 ETPPVPVNGMVHV---ITDIHVGSRINYSCTTG------HRLIGHSSAECILSG-NTAHW 463
PPV NG H + D G+ + Y+C G LIG S+ C + W
Sbjct: 528 PPPPVIYNG-AHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTW 586
Query: 464 SMKPPICQ----QIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGE 519
S P+C+ + C + I NG Y V++ C F L G
Sbjct: 587 SGPAPLCKLSLLAVQCSH-VHIANGYKISGKEAPYFYNDTVTFKC------YSGFTLKGS 639
Query: 520 STIRRTSEPHGNGVWSSPAPRCE 542
S IR ++ W P CE
Sbjct: 640 SQIRCKAD----NTWDPEIPVCE 658
Score = 231 bits (589), Expect = 1e-60
Identities = 165/508 (32%), Positives = 225/508 (44%), Gaps = 48/508 (9%)
Query: 55 FPIGTYLNYECRPGYS--GRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIK- 111
F GT + Y C PGY G SI C VWT +CK +C G + K
Sbjct: 429 FDPGTSIKYSCNPGYVLVGEE-SIQCTSEGVWTPPVPQCKVAACE-----ATGRQLLTKP 482
Query: 112 DIQF-RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFT 170
QF R + SC +GY+L GS C T+ W + +C I C PP I NG T
Sbjct: 483 QHQFVRPDVNSSCGEGYKLSGSVYQEC---QGTIPWFMEIRLCKEITCPPPPVIYNGAHT 539
Query: 171 SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQC---IIP 227
S E F YG+ VTY CN G F L+GE +I CTS D + G WSGPAP C ++
Sbjct: 540 GSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLA 599
Query: 228 NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSR 287
+C+ ++ NG +S + + N+ V F+C GF +KG S ++C+A N W+PE+P C +
Sbjct: 600 VQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEK 659
Query: 288 -VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHC--TPQGDWSPAAPR 344
CQ H ++ ++ S + V SC+ GY L G Y C G W P
Sbjct: 660 ETCQ------HVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPL 713
Query: 345 CEVKSCDDFLGQLPNGHV-LFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM-ESLWN 402
C+V C + H + N G +V + CD+GF L G C W+
Sbjct: 714 CKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWS 773
Query: 403 SSVPVCERK----SCETPPVPVNGMVHVITDIHVGSRINY-SCTTGHRLIGHSSAECILS 457
P C R C P V ++ + + I Y C G + G C +
Sbjct: 774 GPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRC-HT 832
Query: 458 GNTAHWSMKPPICQQ---IFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTF 514
NT W P C + I CP PP NG HTG + G + Y+CD +
Sbjct: 833 DNT--WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCD------QGY 884
Query: 515 NLIGESTIRRTSEPHGNGVWSSPAPRCE 542
L+GE+ + T E G WS PAP C+
Sbjct: 885 LLVGEALLLCTHE----GTWSQPAPHCK 908
Score = 216 bits (551), Expect = 3e-56
Identities = 146/467 (31%), Positives = 205/467 (43%), Gaps = 48/467 (10%)
Query: 119 IKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFH 178
+ YSC GY L+G C+ SG W P C+ C NG
Sbjct: 179 VTYSCESGYLLVGEKIINCLSSGK---WSAVPPTCEEARCKSLGRFPNGKVKE--PPILR 233
Query: 179 YGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENG 238
G + C+ G R L G PS C V W+ P C +PP + NG
Sbjct: 234 VGVTANFFCDEGYR------LQGPPSSRCVIAGQGVA-WT-KMPVCEEIFCPSPPPILNG 285
Query: 239 ILVSDNRSLFSLNEVVEFRCQP------GFGMKGPSHVKC----QALNKWEPELPSC--- 285
+ ++ + S +V + C P F + G S ++C Q W P C
Sbjct: 286 RHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELS 345
Query: 286 -SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPR 344
S V P P +L KD ++ V ++C G+ L+GS + C QG W P+AP
Sbjct: 346 TSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPV 405
Query: 345 CEVKSCDD----FLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL 400
CE K C GQ + H++ G + + C+ G+ L G + C E +
Sbjct: 406 CE-KECQAPPNILNGQKEDRHMV---RFDPGTSIKYSCNPGYVLVGEESIQCT---SEGV 458
Query: 401 WNSSVPVCERKSCETPPVPVNGMVHVITDIH--VGSRINYSCTTGHRLIGHSSAECILSG 458
W VP C+ +CE G + H V +N SC G++L G EC
Sbjct: 459 WTPPVPQCKVAACEA-----TGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQEC---Q 510
Query: 459 NTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIG 518
T W M+ +C++I CP PP I NG HTG+ L D PYG V+YTC+P P+RG+ F+LIG
Sbjct: 511 GTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIG 570
Query: 519 ESTIRRTSEPHGNGVWSSPAPRCELPVGAGSHDALIVGKFYEVFAEE 565
ESTIR TS G WS PAP C+L + A + + Y++ +E
Sbjct: 571 ESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKE 617
Score = 205 bits (521), Expect = 1e-52
Identities = 139/408 (34%), Positives = 189/408 (46%), Gaps = 42/408 (10%)
Query: 156 IICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVG 215
I CG PP I NG + S G+V+ Y C+ F L+GE S+ C +KD G
Sbjct: 21 ISCGSPPPILNGRISYYSTP-IAVGTVIRYSCS------GTFRLIGEKSLLCITKDKVDG 73
Query: 216 IWSGPAPQCIIPNK---CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKC 272
W PAP+C NK C P V G + + + + + V F C+ F M G V C
Sbjct: 74 TWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGS-TPYRHGDSVTFACKTNFSMNGNKSVWC 132
Query: 273 QALNKWEP-ELPSCSRV----CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGS 327
QA N W P LP+C V C P + + T + + +PG V YSCE GY L G
Sbjct: 133 QANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGE 192
Query: 328 TYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGS 387
++C G WS P CE C LG+ PNG V P L++G +F CDEG++L+G
Sbjct: 193 KIINCLSSGKWSAVPPTCEEARCKS-LGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGP 251
Query: 388 SASYCVLAGMESLWNSSVPVCERKSCETPPVPVNG--MVHVITDIHVGSRINYSCT---- 441
+S CV+AG W + +PVCE C +PP +NG + + + ++ GS + Y+C
Sbjct: 252 PSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPE 310
Query: 442 --TGHRLIGHSSAECIL-SGNTAHWSMKPPICQ----QIFCPNPPAILNGRHTGTPLGDI 494
LIG S+ C + S T WS P C+ + CP+ P IL GR
Sbjct: 311 EGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPH-PQILRGRMVSGQKDRY 369
Query: 495 PYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542
Y V + C F L G IR ++ G W AP CE
Sbjct: 370 TYNDTVIFAC------MFGFTLKGSKQIRCNAQ----GTWEPSAPVCE 407
Score = 195 bits (496), Expect = 8e-50
Identities = 116/364 (31%), Positives = 178/364 (48%), Gaps = 29/364 (7%)
Query: 61 LNYECRPGYSGRPFSII-CLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQI 119
+ ++C G++ + S I C ++ W C++++C++ + ++++ S++
Sbjct: 626 VTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQH-------VRQSLQELPAGSRV 678
Query: 120 KY---SCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREY 176
+ SC GY+L G + C + N IW K P+C I C PP I NG T + E
Sbjct: 679 ELVNTSCQDGYQLTGHAYQMCQDAENG-IWFKKIPLCKVIHCHPPPVIVNGKHTGMMAEN 737
Query: 177 FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIP---NKCTPP 233
F YG+ V+Y C+ G F L+GE + C S G WSGP+PQC+ +C P
Sbjct: 738 FLYGNEVSYECDQG------FYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNP 791
Query: 234 NVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV----C 289
V++G ++ S +S N++V C PGF M G ++C N W P +P+C + C
Sbjct: 792 EVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGC 851
Query: 290 QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKS 349
PPP + T + FSPG + YSC+ GY L G L CT +G WS AP C+ +
Sbjct: 852 PPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN 911
Query: 350 CDDFLGQLPNGHVLFPLNL-QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 408
C L P + Q GA V C++G+ L+GS S C + WN + VC
Sbjct: 912 CSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQC---QSDHQWNPPLAVC 968
Query: 409 ERKS 412
+S
Sbjct: 969 RSRS 972
Score = 181 bits (458), Expect = 2e-45
Identities = 105/330 (31%), Positives = 160/330 (48%), Gaps = 19/330 (5%)
Query: 231 TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNK----WEPELPSC- 285
+PP + NG +S + ++ V+ + C F + G + C +K W+ P C
Sbjct: 25 SPPPILNG-RISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCE 83
Query: 286 --SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAA- 342
++ P ++ R + G V ++C+ + + G+ + C W P
Sbjct: 84 YFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRL 143
Query: 343 PRCEVK---SCDDFLGQLPNGHVLFPL--NLQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397
P C C L + NGH ++ G V + C+ G+ L G C+ +G
Sbjct: 144 PTCVSVFPLECPA-LPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK 202
Query: 398 ESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILS 457
W++ P CE C++ NG V + VG N+ C G+RL G S+ C+++
Sbjct: 203 ---WSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIA 259
Query: 458 GNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLI 517
G W+ K P+C++IFCP+PP ILNGRH G L ++ YG V+YTCDP P+ G+ F LI
Sbjct: 260 GQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILI 318
Query: 518 GESTIRRTSEPHGNGVWSSPAPRCELPVGA 547
GEST+R T + G WS PAPRCEL A
Sbjct: 319 GESTLRCTVDSQKTGTWSGPAPRCELSTSA 348
Score = 138 bits (347), Expect = 2e-32
Identities = 126/475 (26%), Positives = 196/475 (41%), Gaps = 54/475 (11%)
Query: 95 SCRNPPDPVNG-MAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNT-VIWDNKTPV 152
SC +PP +NG +++ I + I+YSC +RLIG S CI WD P
Sbjct: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
Query: 153 CDRI--ICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSK 210
C+ P I G + + +G VT+ C K F + G S++C +
Sbjct: 82 CEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFAC------KTNFSMNGNKSVWCQAN 135
Query: 211 DDQVGIWSGPA--PQC--IIPNKCTP-PNVENGILVSDNRSLFSLNEVVEFRCQPGFGMK 265
+ +W GP P C + P +C P + NG S+N + V + C+ G+ +
Sbjct: 136 N----MW-GPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLV 190
Query: 266 GPSHVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDL 324
G + C + KW P+C C+ + + ++ G + C+ GY L
Sbjct: 191 GEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGK--VKEPPILRVGVTANFFCDEGYRL 248
Query: 325 RGSTYLHCTPQGD---WSPAAPRCEVKSCDDFLGQLPNGHVLFPL-NLQLGAKVDFVCD- 379
+G C G W+ P CE C L H+ L N+ G+ V + CD
Sbjct: 249 QGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDP 307
Query: 380 ---EG--FQLKGSSASYCVLAGMES-LWNSSVPVCERKS----CETPPVPVNGMVHVITD 429
EG F L G S C + ++ W+ P CE + C P + MV D
Sbjct: 308 DPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKD 367
Query: 430 IHV-GSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTG 488
+ + ++C G L G C G W P+C++ C PP ILNG+
Sbjct: 368 RYTYNDTVIFACMFGFTLKGSKQIRCNAQGT---WEPSAPVCEK-ECQAPPNILNGQKED 423
Query: 489 TPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
+ G + Y+C+P + L+GE +I+ TSE GVW+ P P+C++
Sbjct: 424 RHMVRFDPGTSIKYSCNP------GYVLVGEESIQCTSE----GVWTPPVPQCKV 468
Score = 117 bits (292), Expect = 4e-26
Identities = 109/438 (24%), Positives = 168/438 (38%), Gaps = 64/438 (14%)
Query: 54 EFPIGTYLNYECRPG-YSGRPFSII------CLKN----SVWTSAKDKCKRKSCRNPPDP 102
+FP GT + Y C PG G FS+I C N W+ CK
Sbjct: 545 DFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSH 604
Query: 103 V---NGMAHVIKDIQ--FRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRII 157
V NG K+ + + + C G+ L GSS C + NT WD + PVC++
Sbjct: 605 VHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRC-KADNT--WDPEIPVCEKET 661
Query: 158 CGLPPTIANGDFTSISREYFHYGS---VVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQV 214
C S + GS +V C G ++L G C +D +
Sbjct: 662 C---------QHVRQSLQELPAGSRVELVNTSCQDG------YQLTGHAYQMC--QDAEN 704
Query: 215 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
GIW P C + + PP + NG F V + C GF + G ++C++
Sbjct: 705 GIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRS 764
Query: 275 LNK----WEPELPSCSR----VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG 326
+K W P C R P P+V H + + +S V+ C PG+ + G
Sbjct: 765 DSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNG 824
Query: 327 STYLHCTPQGDWSPAAPRCEVKSCDDFLG-----QLPNGHVLFP--LNLQLGAKVDFVCD 379
S + C W P P C K+ F+G + PNG+ G + + CD
Sbjct: 825 SRVIRCHTDNTWVPGVPTCIKKA---FIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCD 881
Query: 380 EGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITD---IHVGSRI 436
+G+ L G + C E W+ P C+ +C + P ++G+ + G+ +
Sbjct: 882 QGYLLVGEALLLCT---HEGTWSQPAPHCKEVNCSS-PADMDGIQKGLEPRKMYQYGAVV 937
Query: 437 NYSCTTGHRLIGHSSAEC 454
C G+ L G ++C
Sbjct: 938 TLECEDGYMLEGSPQSQC 955
Score = 92.0 bits (227), Expect = 1e-18
Identities = 79/326 (24%), Positives = 125/326 (38%), Gaps = 26/326 (7%)
Query: 54 EFPIGT---YLNYECRPGY--SGRPFSIIC-LKNSVWTSAKDKCKRKSCRNPPDPVNGM- 106
E P G+ +N C+ GY +G + + +N +W CK C PP VNG
Sbjct: 671 ELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKH 730
Query: 107 -AHVIKDIQFRSQIKYSCPKGYRLIGSSSATCII-SGNTVIWDNKTPVCDRI--ICGLP- 161
+ ++ + +++ Y C +G+ L+G C S W +P C R + P
Sbjct: 731 TGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPN 790
Query: 162 PTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPA 221
P + +G + + + + +V CN G F + G I C + + W
Sbjct: 791 PEVKHGYKLNKTHSAYSHNDIVYVDCNPG------FIMNGSRVIRCHTDNT----WVPGV 840
Query: 222 PQCI---IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKW 278
P CI PP NG N + FS + + C G+ + G + + C W
Sbjct: 841 PTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTW 900
Query: 279 EPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGD 337
P C V C P D+ ++ + + G V CE GY L GS C
Sbjct: 901 SQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQ 960
Query: 338 WSPAAPRCEVKSCDDFLGQLPNGHVL 363
W+P C +S L + G +L
Sbjct: 961 WNPPLAVCRSRSLAPVLCGIAAGLIL 986
>gi|4502503 complement component 4 binding protein, alpha chain
precursor [Homo sapiens]
Length = 597
Score = 204 bits (520), Expect = 1e-52
Identities = 153/552 (27%), Positives = 236/552 (42%), Gaps = 56/552 (10%)
Query: 21 LAALVLLLSSFSDQCNVPEWLPFARPTNLT-DDFEFPIGTYLNYECRPGY--SGRPFSII 77
+ + LL + C P L FA P ++T + F GT L Y C PGY S ++
Sbjct: 36 MTLIAALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLT 95
Query: 78 CLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATC 137
C + W C K CR+P + NG + D+ F SQI++SC +G+ LIGS+++ C
Sbjct: 96 CNSDGEWVY-NTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRC 154
Query: 138 IISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVF 197
+ V W + P C+ + C PP I NG + ++ YG VTY C+ F
Sbjct: 155 EVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSG-EENFYAYGFSVTYSCD------PRF 207
Query: 198 ELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFR 257
L+G SI CT +++ +G+W P+P C P+V +G +VS +++ + + F+
Sbjct: 208 SLLGHASISCTVENETIGVWR-PSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFK 266
Query: 258 CQPGFGMKGPSHVKCQALNKWEPELPSCS-RVCQPPPDVLHAE----RTQRDKDNFSPGQ 312
CQ GF ++G S + C A +KW P P+C C PD+ HA +D + G
Sbjct: 267 CQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGT 326
Query: 313 EVFYSCEPGY--DLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVL-----FP 365
+ Y C PGY T + C W+P CE C + +L NG + P
Sbjct: 327 VLRYRCHPGYKPTTDEPTTVICQKNLRWTP-YQGCEALCCPE--PKLNNGEITQHRKSRP 383
Query: 366 LN---LQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNG 422
N G ++ F C E ++ + + + W+ P C C PP +G
Sbjct: 384 ANHCVYFYGDEISFSCHE-------TSRFSAICQGDGTWSPRTPSC-GDICNFPPKIAHG 435
Query: 423 MVHVITDI-HVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAI 481
+ I Y C G+ L+G + C S HWS P C+ + P +
Sbjct: 436 HYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYS----HWSAPAPQCKALC--RKPEL 489
Query: 482 LNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
+NGR + V+ CD + ++G +I + GN W P+C
Sbjct: 490 VNGR-LSVDKDQYVEPENVTIQCD------SGYGVVGPQSITCS----GNRTWYPEVPKC 538
Query: 542 ELPVGAGSHDAL 553
E G L
Sbjct: 539 EWETPEGCEQVL 550
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 202 bits (515), Expect = 5e-52
Identities = 149/496 (30%), Positives = 216/496 (43%), Gaps = 55/496 (11%)
Query: 59 TYLNYECRPGYSGR-PFSIICLKNSVWTSAKDK--CKRKSCRNPPDPVNGMAHVIKDIQF 115
T + + C PGY G P SI CL N W+ ++ C+ SC P P NG + +
Sbjct: 2679 TKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNK-IGTQTSY 2737
Query: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
S ++C G+ L+GS+ C+ SG +W C CG+P I NG + E
Sbjct: 2738 GSTAIFTCDLGFMLVGSAVRECLSSG---LWSESETRCLAGHCGIPELIVNGQ---VIGE 2791
Query: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235
+ Y V Y CN G F L+G C + WSG P C+ P C P
Sbjct: 2792 NYGYRDTVVYQCNPG------FRLIGSSVRICQQDHN----WSGQLPSCV-PVSCGHPG- 2839
Query: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV-CQPPPD 294
+ I + + F+ N+VV F C G+ M+GP+ +CQA +W P C V C P
Sbjct: 2840 -SPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGI 2898
Query: 295 VLHAERTQR-DKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDF 353
+++R + + NF+ G VFY C PGY L GS+ L C P G W P C + C
Sbjct: 2899 PANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGH- 2957
Query: 354 LGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE---R 410
+P VL G+ V + C L G S+ C L G W+ S P C
Sbjct: 2958 -PGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDAT 3013
Query: 411 KSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPIC 470
+C P P +G ++ S + Y+C TG+ L G C+ +G+ W+ + P C
Sbjct: 3014 GTCGDPGTPGHGS-RQESNFRTKSTVRYACDTGYILHGSEERTCLANGS---WTGRQPEC 3069
Query: 471 QQIFCPNPPAILNG---RHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSE 527
+ + C NP NG R GT + V Y+C M ++ ++R+ +
Sbjct: 3070 KAVQCGNPGTTANGKVFRIDGT-----TFSSSVIYSC-------MEGYILSGPSVRQCT- 3116
Query: 528 PHGNGVWSSPAPRCEL 543
NG WS P C +
Sbjct: 3117 --ANGTWSGTLPNCTI 3130
Score = 195 bits (496), Expect = 8e-50
Identities = 147/503 (29%), Positives = 206/503 (40%), Gaps = 50/503 (9%)
Query: 63 YECRPGYSGRPFSI-ICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKY 121
Y+C PG+ S+ IC ++ W+ C SC +P P+ G F + +
Sbjct: 2801 YQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSG-NGFNFNDVVTF 2859
Query: 122 SCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTS-ISREYFHYG 180
SC GY + G + A C + W + P+C + C P AN S I F YG
Sbjct: 2860 SCNIGYLMQGPTKAQCQANRQ---WSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYG 2916
Query: 181 SVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGIL 240
+VV Y CN G + L G + C G W P P+CI+ + C P V +
Sbjct: 2917 TVVFYDCNPG------YFLFGSSVLICQPN----GQWDKPLPECIMID-CGHPGVPPNAV 2965
Query: 241 VSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSR----VCQPPPDVL 296
+S + ++ V + C + G S CQ W P CS C P
Sbjct: 2966 LSGEK--YTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPG 3023
Query: 297 HAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQ 356
H R + NF V Y+C+ GY L GS C G W+ P C+ C + G
Sbjct: 3024 HGSRQE---SNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGN-PGT 3079
Query: 357 LPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETP 416
NG V + V + C EG+ L G S C G W+ ++P C SC P
Sbjct: 3080 TANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT---WSGTLPNCTIISCGDP 3136
Query: 417 PVPVNGMVHVITDIHVGSRINYSCTTGH--RLIGHSSAECILSGNTAHWSMKPPICQQIF 474
+P NG+ + D VG ++Y C G+ L G C ++G WS P C+ +
Sbjct: 3137 GIPANGLRYG-DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVT 3192
Query: 475 CPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVW 534
CP PP I NGR GT + +G +SY C P + ++F + GNG W
Sbjct: 3193 CPTPPQISNGRLEGT---NFDWGFSISYICSPGYE--LSFPAVLTCV--------GNGTW 3239
Query: 535 SSPAPRCELPVGAGSHDALIVGK 557
S P+C LP G GK
Sbjct: 3240 SGEVPQC-LPKFCGDPGIPAQGK 3261
Score = 171 bits (433), Expect = 2e-42
Identities = 147/496 (29%), Positives = 204/496 (41%), Gaps = 51/496 (10%)
Query: 55 FPIGTYLNYECRPGYSGRPFSI-ICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDI 113
F GT + Y+C PGY S+ IC N W +C C +P P N + K
Sbjct: 2913 FTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEK-Y 2971
Query: 114 QFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCD---RIICGLPPTIANGDFT 170
F S + YSC L+G SS TC ++G+ W P C CG P T +G
Sbjct: 2972 TFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPGTPGHG--- 3025
Query: 171 SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKC 230
S F S V Y C+ G + L G C + G W+G P+C
Sbjct: 3026 SRQESNFRTKSTVRYACDTG------YILHGSEERTCLAN----GSWTGRQPECKAVQCG 3075
Query: 231 TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQ 290
P NG + + + FS + V + C G+ + GPS +C A W LP+C+ +
Sbjct: 3076 NPGTTANGKVFRIDGTTFSSS--VIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISC 3133
Query: 291 PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY--DLRGSTYLHCTPQGDWSPAAPRCEVK 348
P + R D++ GQ V Y C+PGY +L GS CT G WS P C
Sbjct: 3134 GDPGI--PANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV 3191
Query: 349 SCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 408
+C Q+ NG L N G + ++C G++L + CV G W+ VP C
Sbjct: 3192 TCPT-PPQISNGR-LEGTNFDWGFSISYICSPGYELSFPAVLTCVGNG---TWSGEVPQC 3246
Query: 409 ERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPP 468
K C P +P G + I+ S +++SC L+G S+ C G WS P
Sbjct: 3247 LPKFCGDPGIPAQGKREGKSFIY-QSEVSFSCNFPFILVGSSTRICQADGT---WSGSSP 3302
Query: 469 IC---QQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRT 525
C Q C NP +G T +G +V H +G +L+ ST RT
Sbjct: 3303 HCIEPTQTSCENPGVPRHGSQNNT------FGFQVGSVVQFHCKKG---HLLQGST-TRT 3352
Query: 526 SEPHGNGVWSSPAPRC 541
P + WS P C
Sbjct: 3353 CLP--DLTWSGIQPEC 3366
Score = 160 bits (405), Expect = 3e-39
Identities = 122/398 (30%), Positives = 166/398 (41%), Gaps = 30/398 (7%)
Query: 78 CLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATC 137
CL N WT + +CK C NP NG I F S + YSC +GY L G S C
Sbjct: 3056 CLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQC 3115
Query: 138 IISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVF 197
+G W P C I CG P ANG +Y G V+Y C G
Sbjct: 3116 TANGT---WSGTLPNCTIISCGDPGIPANG--LRYGDDYV-VGQNVSYMCQPG----YTM 3165
Query: 198 ELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFR 257
EL G CT G WSG P C TPP + NG L N F + +
Sbjct: 3166 ELNGSRIRTCTIN----GTWSGVMPTCRAVTCPTPPQISNGRLEGTN---FDWGFSISYI 3218
Query: 258 CQPGFGMKGPSHVKCQALNKWEPELPSC-SRVCQPPPDVLHAERTQRDKDNFSPGQEVFY 316
C PG+ + P+ + C W E+P C + C P + +R+ +F EV +
Sbjct: 3219 CSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPG---IPAQGKREGKSFIYQSEVSF 3275
Query: 317 SCEPGYDLRGSTYLHCTPQGDWSPAAPRC---EVKSCDDFLGQLPNGHVLFPLNLQLGAK 373
SC + L GS+ C G WS ++P C SC++ G +G Q+G+
Sbjct: 3276 SCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCEN-PGVPRHGSQNNTFGFQVGSV 3334
Query: 374 VDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG 433
V F C +G L+GS+ C+ + W+ P C SC+ P P + V + G
Sbjct: 3335 VQFHCKKGHLLQGSTTRTCL---PDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHG 3391
Query: 434 SRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQ 471
+ Y+C G L G + S NT W+ K PIC+
Sbjct: 3392 YTLIYTCQPGFFLAGGTEHRVCRSDNT--WTGKVPICE 3427
Score = 159 bits (403), Expect = 5e-39
Identities = 133/464 (28%), Positives = 193/464 (41%), Gaps = 60/464 (12%)
Query: 96 CRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISG-NTVIWDNKTPVCD 154
C P P +G Q S ++++C +G+RL+G SSA C S WD P C
Sbjct: 2529 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2588
Query: 155 RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSR--GKKVFELVGEPSIYCTSKDD 212
I CG+P NG ++ +Y G+ VTY CN G R K++ V C S
Sbjct: 2589 AISCGIPKAPTNGGI--LTTDYL-VGTRVTYFCNDGYRLSSKELTTAV------CQSD-- 2637
Query: 213 QVGIWS--GPAPQCIIPNKCTPPNVENGILVSD-----NRSLFSLNEVVEFRCQPGFGMK 265
G WS P+C++ T P++ + IL N S + V F C PG+
Sbjct: 2638 --GTWSNHNKTPRCVV---VTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGL 2692
Query: 266 GPSHVKC--QALNKWEPELP-----SCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSC 318
GP+ ++C W E P SC + PP +T S G ++C
Sbjct: 2693 GPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQT-------SYGSTAIFTC 2745
Query: 319 EPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVC 378
+ G+ L GS C G WS + RC C + NG V+ N V + C
Sbjct: 2746 DLGFMLVGSAVRECLSSGLWSESETRCLAGHC-GIPELIVNGQVIGE-NYGYRDTVVYQC 2803
Query: 379 DEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINY 438
+ GF+L GSS C + W+ +P C SC P P+ G + + +
Sbjct: 2804 NPGFRLIGSSVRIC---QQDHNWSGQLPSCVPVSCGHPGSPIYGRTSG-NGFNFNDVVTF 2859
Query: 439 SCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNG-RHTGTPLGDIPYG 497
SC G+ + G + A+C + WS PP+C+ + C +P N R + G+ YG
Sbjct: 2860 SCNIGYLMQGPTKAQCQAN---RQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYG 2916
Query: 498 KEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
V Y C+P + L G S + +P NG W P P C
Sbjct: 2917 TVVFYDCNP------GYFLFGSSVL--ICQP--NGQWDKPLPEC 2950
Score = 132 bits (331), Expect = 1e-30
Identities = 154/606 (25%), Positives = 225/606 (37%), Gaps = 115/606 (18%)
Query: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYS--GRPFSIICLKNS----VWTSAK 88
C+ PE P + T + + + + C G+ G+ S +C K+S W +
Sbjct: 2529 CSTPESPPHGYIISQTGG---QLNSVVRWACDRGFRLVGKS-SAVCRKSSYGYHAWDAPV 2584
Query: 89 DKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCII-SGNTVIWD 147
C+ SC P P NG + D +++ Y C GYRL T + S T
Sbjct: 2585 PACQAISCGIPKAPTNG-GILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNH 2643
Query: 148 NKTPVCDRIICGLPPTI-----ANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGE 202
NKTP C + C P+I +G + ++ ++ Y + V + C+ G G +G
Sbjct: 2644 NKTPRCVVVTC---PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHG------LGP 2694
Query: 203 PSIYCTSKDDQVGIWSGPAPQCIIPNKC----TPPN-----------------VENGILV 241
SI C + W P C I + C TPPN + G ++
Sbjct: 2695 ASIECL--PNGTWSWRNERPYCQIIS-CGELPTPPNGNKIGTQTSYGSTAIFTCDLGFML 2751
Query: 242 ----------------SDNRSL-------------------FSLNEVVEFRCQPGFGMKG 266
S+ R L + + V ++C PGF + G
Sbjct: 2752 VGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIG 2811
Query: 267 PSHVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLR 325
S CQ + W +LPSC V C P ++ RT + NF+ V +SC GY ++
Sbjct: 2812 SSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYG-RTSGNGFNFN--DVVTFSCNIGYLMQ 2868
Query: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDD--FLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQ 383
G T C WS P C+V +C D + N G V + C+ G+
Sbjct: 2869 GPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYF 2928
Query: 384 LKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTG 443
L GSS C G W+ +P C C P VP N ++ GS ++YSCT
Sbjct: 2929 LFGSSVLICQPNGQ---WDKPLPECIMIDCGHPGVPPNAVLSG-EKYTFGSTVHYSCTGK 2984
Query: 444 HRLIGHSSAECILSGNTAHWSMKPPICQ---QIFCPNPPAILNGRHTGTPLGDIPYGKEV 500
L+G SS C L+G HWS P C C +P H + V
Sbjct: 2985 RSLLGQSSRTCQLNG---HWSGSQPHCSGDATGTCGDPG---TPGHGSRQESNFRTKSTV 3038
Query: 501 SYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVGAGSHDALIVGKFYE 560
Y CD I + RT NG W+ P C+ V G+ GK +
Sbjct: 3039 RYACDT--------GYILHGSEERTC--LANGSWTGRQPECK-AVQCGNPGTTANGKVFR 3087
Query: 561 VFAEEF 566
+ F
Sbjct: 3088 IDGTTF 3093
Score = 127 bits (319), Expect = 3e-29
Identities = 107/361 (29%), Positives = 142/361 (39%), Gaps = 40/361 (11%)
Query: 63 YECRPGY--SGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIK 120
Y C GY SG P C N W+ C SC +P P NG+ + D +
Sbjct: 3099 YSCMEGYILSG-PSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYG-DDYVVGQNVS 3156
Query: 121 YSCPKGY--RLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFH 178
Y C GY L GS TC I+G W P C + C PP I+NG + F
Sbjct: 3157 YMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVTCPTPPQISNGRLEGTN---FD 3210
Query: 179 YGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENG 238
+G ++Y C+ G +EL + C G WSG PQC+ P C P G
Sbjct: 3211 WGFSISYICSPG------YELSFPAVLTCVGN----GTWSGEVPQCL-PKFCGDP----G 3255
Query: 239 ILVSDNRS--LFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSC----SRVCQPP 292
I R F V F C F + G S CQA W P C C+ P
Sbjct: 3256 IPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENP 3315
Query: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDD 352
H +Q + F G V + C+ G+ L+GST C P WS P C SC
Sbjct: 3316 GVPRHG--SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQ 3373
Query: 353 FLGQLPNGHVLFPLNLQL-GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERK 411
+ P + ++L G + + C GF L G + + ++ W VP+CE
Sbjct: 3374 --PETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR--VCRSDNTWTGKVPICEAG 3429
Query: 412 S 412
S
Sbjct: 3430 S 3430
Score = 113 bits (283), Expect = 4e-25
Identities = 88/304 (28%), Positives = 125/304 (41%), Gaps = 29/304 (9%)
Query: 54 EFPIGTYLNYECRPGYS---GRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVI 110
++ +G ++Y C+PGY+ C N W+ C+ +C PP NG
Sbjct: 3148 DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEG- 3206
Query: 111 KDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFT 170
+ + I Y C GY L + TC+ +G W + P C CG P A G
Sbjct: 3207 TNFDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCLPKFCGDPGIPAQGKRE 3263
Query: 171 SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNK- 229
S F Y S V++ CN F LVG + C + G WSG +P CI P +
Sbjct: 3264 GKS---FIYQSEVSFSCNF------PFILVGSSTRICQAD----GTWSGSSPHCIEPTQT 3310
Query: 230 -CTPPNV-ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSC-S 286
C P V +G +N F + VV+F C+ G ++G + C W P C
Sbjct: 3311 SCENPGVPRHG--SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIP 3368
Query: 287 RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGST-YLHCTPQGDWSPAAPRC 345
C+ P HA D S G + Y+C+PG+ L G T + C W+ P C
Sbjct: 3369 HSCKQPETPAHANVVGMDLP--SHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC 3426
Query: 346 EVKS 349
E S
Sbjct: 3427 EAGS 3430
Score = 85.9 bits (211), Expect = 9e-17
Identities = 124/506 (24%), Positives = 183/506 (36%), Gaps = 96/506 (18%)
Query: 94 KSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVC 153
+SC +P NG + D I + C GY LIG+S+ TC+ G + W++ P C
Sbjct: 2182 QSCPDPRPFRNGFV-IGNDFTVGQTISFECFPGYTLIGNSALTCL-HGVSRNWNHPLPRC 2239
Query: 154 DRIICGLPPTIANGDFTS--ISREYFHYGSVVTYHCNLGSRGKKV-FELVGEPSIYCTSK 210
+ + CG T NG S EY ++ G + F ++ IY
Sbjct: 2240 EAL-CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIY---- 2294
Query: 211 DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHV 270
D + +W GP P + + S++S + + + F G +
Sbjct: 2295 -DFITVWDGPDQNS--------PQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVL 2345
Query: 271 KCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYL 330
A RVCQPPP V +AE D D F G + Y C PG+ L G+ L
Sbjct: 2346 SYHAYQL---------RVCQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFTLVGNAIL 2395
Query: 331 HCT--PQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFP------LNLQLGAKVDFVCDEGF 382
C + A P C+V + L G +L P NLQ+ A ++G+
Sbjct: 2396 TCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCA-WSISVEKGY 2454
Query: 383 QL-------------------KGSSASYCVLAGMESLWNSSVPVCERKS----------- 412
+ G + VL + ++S+ +
Sbjct: 2455 NITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHG 2514
Query: 413 --------------CETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSG 458
C TP P +G + T + S + ++C G RL+G SSA C S
Sbjct: 2515 NNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSS 2574
Query: 459 NTAH-WSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLI 517
H W P CQ I C P A NG G D G V+Y C+ + L
Sbjct: 2575 YGYHAWDAPVPACQAISCGIPKAPTNG---GILTTDYLVGTRVTYFCND------GYRL- 2624
Query: 518 GESTIRRTSEPHGNGVWS--SPAPRC 541
S T+ +G WS + PRC
Sbjct: 2625 -SSKELTTAVCQSDGTWSNHNKTPRC 2649
Score = 67.4 bits (163), Expect = 3e-11
Identities = 97/432 (22%), Positives = 157/432 (36%), Gaps = 76/432 (17%)
Query: 93 RKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGN-TVIWDNKTP 151
R+SC +P + +NG + D + S + Y C GY L G S+ TCI+ + W+ P
Sbjct: 1658 RESCFDPGNIMNG-TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716
Query: 152 VCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKD 211
C CG T + G T +S Y SV ++C K F + G+ + TS
Sbjct: 1717 SC-HAPCGSRSTGSEG--TVLSPNYPKNYSV-GHNCVYSIAVPKEFVVFGQFVFFQTSLH 1772
Query: 212 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVK 271
D V ++ GP Q + + + + + +S + + F KG H
Sbjct: 1773 DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQI-----TIRFTSVGPITAKG-FHFV 1826
Query: 272 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLH 331
QA+ + CS V +P +R + F+ G V + C PGY L GS +
Sbjct: 1827 YQAVPRTSST--QCSSVPEP-------RFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIR 1877
Query: 332 C----TPQGDWSPAAPRCEVKSCDDFL----GQLPNGHVLFPLNLQLGAKVDFVCDEGFQ 383
C W+ + P C + C L G + + P + L EG
Sbjct: 1878 CETVPNSLAQWNDSLPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAG 1936
Query: 384 LKGSSASYCVLAGMESL-----WNSSVPVCERKSCETPPVPVNGMVHVI----------- 427
++ S+ +SL +++ P S T P +N + +
Sbjct: 1937 IQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVS 1996
Query: 428 -----------------------TDIHVGSR------INYSCTTGHRLIGHSSAECILSG 458
+ I +G R +++ C G+ L GHS C + G
Sbjct: 1997 AAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITC-MPG 2055
Query: 459 NTAHWSMKPPIC 470
W+ PIC
Sbjct: 2056 PVRRWNYPIPIC 2067
Score = 58.2 bits (139), Expect = 2e-08
Identities = 107/470 (22%), Positives = 157/470 (33%), Gaps = 101/470 (21%)
Query: 61 LNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIK 120
L ++ SGR F+I + C +P P+N + Q S I
Sbjct: 769 LEFQADHSMSGRGFNI----------TYNTFGHNECPDPGIPINARRFG-DNFQLGSSIS 817
Query: 121 YSCPKGY-RLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHY 179
C +G+ + G+ + TCI+ V+W P C G P G F++ S
Sbjct: 818 VICEEGFIKTQGTETITCILMDGKVMWSGLIPKC-----GAP---CGGHFSAPSGVILSP 869
Query: 180 GSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPP-NVENG 238
G Y +L V E SI T + Q + PN +P NG
Sbjct: 870 GWPGYYKDSLNCEW--VIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNG 927
Query: 239 -----ILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPP 293
L S + ++ L R GF + H + +N + C P
Sbjct: 928 TQVPQFLFSSSNFIYLLFTTDNSRSNNGFKI----HYESVTVNTYS---------CLDPG 974
Query: 294 DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDF 353
+H R D FS G V +SC+ GY L L C WS P C+ D
Sbjct: 975 IPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDV 1031
Query: 354 LGQLPNGHVL-------FPLNLQLGAKVDFVCDEGFQ----------------------- 383
G P+G +L +P +L VD +G Q
Sbjct: 1032 RG--PSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSF 1089
Query: 384 ------LKGSSASYCVLAGMESL-----------------WNSSVPVCERKSCETPPVPV 420
L GS + AG+ +N + + CE P +P
Sbjct: 1090 TQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQ 1149
Query: 421 NGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPIC 470
G + + +G + +SC++G+RL G S C L G WS P C
Sbjct: 1150 YGS-RIGFNFGIGDTLTFSCSSGYRLEGTSEIIC-LGGGRRVWSAPLPRC 1197
Score = 57.0 bits (136), Expect = 5e-08
Identities = 102/442 (23%), Positives = 157/442 (35%), Gaps = 59/442 (13%)
Query: 117 SQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREY 176
S I Y C GY L GSS C+ +G WD P C G ++G S
Sbjct: 1335 STIIYGCNPGYTLHGSSLLKCM-TGERRAWDYPLPSCIAECGGRFKGESSGRILSP---- 1389
Query: 177 FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKD-----DQVGIWSGPAPQCIIPNKCT 231
G Y NL + S+ + D D + +W GP ++ + +
Sbjct: 1390 ---GYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDMLLKEIS 1446
Query: 232 PPNVENGILVSDNRSLFSLNEVVEFRC-QPGFGMKGPSHVKCQALNKWEPELPSCSRVCQ 290
+ GI + N + ++ +F + GF ++ S V + C+
Sbjct: 1447 GSLIPEGIHSTLN--IVTIQFDTDFYISKSGFAIQFSSSV---------------ATACR 1489
Query: 291 PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGD---WSPAAPRCEV 347
P ++ R + D PG V + C+PGY+L+G + C + W P+ P C
Sbjct: 1490 DPGVPMNGTR---NGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA 1546
Query: 348 KSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPV 407
+ G +G +L P N CD + +A Y + S S P
Sbjct: 1547 PCGGNLTGS--SGFILSP-NFPHPYPHSRDCDWTITV---NADYVISLAFISF--SIEPN 1598
Query: 408 CERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKP 467
+ P + ++ D + RI S T H L S +G H K
Sbjct: 1599 YDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMH-LAFRSDGSVSYTG--FHLEYKA 1655
Query: 468 PICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSE 527
+ + C +P I+NG G D G V+Y CD + L G ST+
Sbjct: 1656 KLRES--CFDPGNIMNGTRLGM---DYKLGSTVTYYCD------AGYVLQGYSTLTCIMG 1704
Query: 528 PHGNGVWSSPAPRCELPVGAGS 549
G W+ P C P G+ S
Sbjct: 1705 DDGRPGWNRALPSCHAPCGSRS 1726
Score = 53.1 bits (126), Expect = 7e-07
Identities = 106/477 (22%), Positives = 159/477 (33%), Gaps = 60/477 (12%)
Query: 80 KNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATC-I 138
K S+ K C +P +P NG + D S +++SC + Y L G+ S TC
Sbjct: 430 KFSILNEGGIKTASNLCPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQR 488
Query: 139 ISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFE 198
I+ W + PVC CG +G FTS + + + + KV +
Sbjct: 489 IAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQ 548
Query: 199 LVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRC 258
+ E D + I G + + T V G V D S + +
Sbjct: 549 INFE-EFDLEIGYDTLTIGDGGE----VGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQT 603
Query: 259 QPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSC 318
G G +N E E SC P + R+ D FS + + C
Sbjct: 604 DESVGSVG------FKVNYKEIEKESCGDPGTPLYGI-------REGDGFSNRDVLRFEC 650
Query: 319 EPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFP-----LNLQLGAK 373
+ G++L G + C WS P C +F P G VL P L
Sbjct: 651 QFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTA--PMGTVLSPDYPEGYGNNLNCI 708
Query: 374 VDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG 433
+ D G ++ S + + S K ++P P+ G T V
Sbjct: 709 WTIISDPGSRIHLSFNDFDL--------ESQFDFLAVKDGDSPESPILG---TFTGAEVP 757
Query: 434 SRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIF----CPNPPAILNGRHTGT 489
S + + H L A+ +SG + I F CP+P +N R G
Sbjct: 758 SHLT---SNSHILRLEFQADHSMSGRGFN------ITYNTFGHNECPDPGIPINARRFG- 807
Query: 490 PLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVG 546
+ G +S C+ G TI G +WS P+C P G
Sbjct: 808 --DNFQLGSSISVICEEG-----FIKTQGTETI-TCILMDGKVMWSGLIPKCGAPCG 856
Score = 52.8 bits (125), Expect = 9e-07
Identities = 28/64 (43%), Positives = 35/64 (54%), Gaps = 2/64 (3%)
Query: 409 ERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECIL-SGNTAHWSMKP 467
+ SC P VP G+++ T VG +I YSC TG+ L GH CI S NTA W
Sbjct: 134 QSSSCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPV 192
Query: 468 PICQ 471
PIC+
Sbjct: 193 PICR 196
Score = 46.6 bits (109), Expect = 6e-05
Identities = 95/434 (21%), Positives = 144/434 (33%), Gaps = 90/434 (20%)
Query: 95 SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCD 154
SC +P PV+G + D S + +SC GYRL C W + P CD
Sbjct: 969 SCLDPGIPVHGRRYG-HDFSIGSTVSFSCDSGYRLSHEEPLLC---EKNHWWSHPLPTCD 1024
Query: 155 RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKV------FELVGEPSIYCT 208
+ CG +G S F+ S+ + GK V F L
Sbjct: 1025 AL-CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLI 1083
Query: 209 SKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEV-VEFRCQPGFGMKGP 267
+++ S P + PP + G+ + L +++ + + GF +
Sbjct: 1084 TENG-----SFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYE---GFNITFS 1135
Query: 268 SHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGS 327
+ EP C+ P + R NF G + +SC GY L G+
Sbjct: 1136 EY-------NLEP--------CEDPGIPQYGSRIGF---NFGIGDTLTFSCSSGYRLEGT 1177
Query: 328 TYLHCTPQGD--WSPAAPRCEVK-------------SCDDFLGQLPNGHVLFPLNLQLGA 372
+ + C G WS PRC + S + L N ++ + +Q G
Sbjct: 1178 SEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGK 1237
Query: 373 KVD-----FVCDEGFQLK----------------GSSASYCVLAGMES-LW---NSSVPV 407
++ F +G LK G+S L+ + LW NS
Sbjct: 1238 GINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEG 1297
Query: 408 C-----------ERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECIL 456
E CE P +P G GS I Y C G+ L G S +C +
Sbjct: 1298 TDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKC-M 1356
Query: 457 SGNTAHWSMKPPIC 470
+G W P C
Sbjct: 1357 TGERRAWDYPLPSC 1370
Score = 43.9 bits (102), Expect = 4e-04
Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 2/66 (3%)
Query: 89 DKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCII-SGNTVIWD 147
++ + SC NP P G+ + + +I+YSC GY L G TCI S NT WD
Sbjct: 131 EELQSSSCGNPGVPPKGVLYGTR-FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWD 189
Query: 148 NKTPVC 153
P+C
Sbjct: 190 FPVPIC 195
Score = 40.8 bits (94), Expect = 0.003
Identities = 104/467 (22%), Positives = 167/467 (35%), Gaps = 76/467 (16%)
Query: 96 CRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVI-WDNKTPVCD 154
C + P+P G + + S + + C GY L GS + C N++ W++ P C
Sbjct: 1838 CSSVPEPRFGR-RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCI 1896
Query: 155 RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGK-KVFELVG---EPSIYCTSK 210
+ CG G T G Y NL K V E G + + T
Sbjct: 1897 -VPCG-------GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH 1948
Query: 211 D-DQVGIWSGP---APQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKG 266
+ D + + G AP+ + T P++ N S N + F+ G
Sbjct: 1949 NWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNST---------SNNLYLNFQSDISVSAAG 1999
Query: 267 PSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG 326
H++ A+ L SC P + + D + G V + C+ GY L+G
Sbjct: 2000 -FHLEYTAIG-----LDSCPEPQTPSSGI-------KIGDRYMVGDVVSFQCDQGYSLQG 2046
Query: 327 STYLHCTPQG--DWSPAAPRCEVK---SCDDFLGQL--PNGHVLFPLNLQLGAKVDFVCD 379
+++ C P W+ P C + + DF G + P +P +L ++
Sbjct: 2047 HSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIG 2106
Query: 380 EGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYS 439
G L+ + S + + + S ET V + ++ + S + +S
Sbjct: 2107 FGVHLQFVNFSTETIHDYLEVRSGS--------SETSTV-----IGRLSGPQIPSSL-FS 2152
Query: 440 CTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKE 499
T L HS S N + + Q CP+P NG G D G+
Sbjct: 2153 TTHETSLYFHSD----YSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGN---DFTVGQT 2205
Query: 500 VSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVG 546
+S+ C P + LIG S + N W+ P PRCE G
Sbjct: 2206 ISFECFPG------YTLIGNSALTCLHGVSRN--WNHPLPRCEALCG 2244
Score = 40.4 bits (93), Expect = 0.004
Identities = 63/274 (22%), Positives = 101/274 (36%), Gaps = 30/274 (10%)
Query: 96 CRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDR 155
C +P P G + + + + +SC GYRL G+S C+ G V W P C
Sbjct: 1142 CEDPGIPQYG-SRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRV-WSAPLPRCVA 1199
Query: 156 IICGLPPTIANGDFTSISREY-FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQV 214
CG T N + +S Y +Y + + C + + + + ++ D +
Sbjct: 1200 E-CGASAT--NNEGILLSPNYPLNYEN--NHECIYSIQVQAGKGINISARTFHLAQGDVL 1254
Query: 215 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLF-SLNEVVEFRCQPGFGMKGPSHVKCQ 273
I+ G + T ++ L S + L+ N E GF + S
Sbjct: 1255 KIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTE-GTDEGFQLVYTSF---- 1309
Query: 274 ALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCT 333
EL C P + D+ +F+ G + Y C PGY L GS+ L C
Sbjct: 1310 -------ELSHCE-----DPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCM 1356
Query: 334 --PQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFP 365
+ W P C + F G+ +G +L P
Sbjct: 1357 TGERRAWDYPLPSCIAECGGRFKGE-SSGRILSP 1389
Score = 37.7 bits (86), Expect = 0.029
Identities = 67/302 (22%), Positives = 102/302 (33%), Gaps = 53/302 (17%)
Query: 228 NKCTPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGF-GMKGPSHVKCQALN---KWEPEL 282
N+C P + N DN F L + C+ GF +G + C ++ W +
Sbjct: 792 NECPDPGIPINARRFGDN---FQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLI 848
Query: 283 PSCSRVC----QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDW 338
P C C P V+ SPG +Y L + P
Sbjct: 849 PKCGAPCGGHFSAPSGVI-----------LSPGWPGYYKDS----LNCEWVIEAEPGHSI 893
Query: 339 SPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 398
R + + D L ++L PL LG+ + F S+ Y +
Sbjct: 894 KITFERFQTELNYDVLEVHDGPNLLSPL---LGSYNGTQVPQ-FLFSSSNFIYLLFTTDN 949
Query: 399 SLWNSSVPV------CERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSA 452
S N+ + SC P +PV+G + D +GS +++SC +G+RL S
Sbjct: 950 SRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYG-HDFSIGSTVSFSCDSGYRL---SHE 1005
Query: 453 ECILSGNTAHWSMKPPICQ------------QIFCPNPPAILNGRHTGTPLGDIPYGKEV 500
E +L WS P C I P P T D+ +GK V
Sbjct: 1006 EPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGV 1065
Query: 501 SY 502
+
Sbjct: 1066 QF 1067
Score = 37.0 bits (84), Expect = 0.049
Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 1/59 (1%)
Query: 95 SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVC 153
+CR+P P+NG + + + + C GY L G TCI N W PVC
Sbjct: 1487 ACRDPGVPMNGTRNG-DGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1544
Score = 33.9 bits (76), Expect = 0.41
Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 4/80 (5%)
Query: 346 EVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 405
+++SC D NG V+ + +G + F C G+ L G+SA C L G+ WN +
Sbjct: 2180 QLQSCPD-PRPFRNGFVIGN-DFTVGQTISFECFPGYTLIGNSALTC-LHGVSRNWNHPL 2236
Query: 406 PVCERKSCETPPVPVNGMVH 425
P CE C +NG ++
Sbjct: 2237 PRCE-ALCGGNITAMNGTIY 2255
Score = 32.3 bits (72), Expect = 1.2
Identities = 22/74 (29%), Positives = 27/74 (36%), Gaps = 11/74 (14%)
Query: 279 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQ--- 335
E + SC PP VL+ R F G ++ YSC GY L G L C
Sbjct: 132 ELQSSSCGNPGVPPKGVLYGTR-------FDVGDKIRYSCVTGYILDGHPQLTCIANSVN 184
Query: 336 -GDWSPAAPRCEVK 348
W P C +
Sbjct: 185 TASWDFPVPICRAE 198
Score = 31.2 bits (69), Expect = 2.7
Identities = 15/36 (41%), Positives = 21/36 (58%), Gaps = 2/36 (5%)
Query: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYS 70
C P +P A LT+D EF IG + Y+C PG++
Sbjct: 2355 CQPPPPVPNAEI--LTEDDEFEIGDIIRYQCLPGFT 2388
Score = 29.6 bits (65), Expect = 7.8
Identities = 14/53 (26%), Positives = 25/53 (47%), Gaps = 1/53 (1%)
Query: 357 LPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL-WNSSVPVC 408
+P VL+ +G K+ + C G+ L G C+ + + W+ VP+C
Sbjct: 143 VPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 195
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 202 bits (515), Expect = 5e-52
Identities = 149/496 (30%), Positives = 216/496 (43%), Gaps = 55/496 (11%)
Query: 59 TYLNYECRPGYSGR-PFSIICLKNSVWTSAKDK--CKRKSCRNPPDPVNGMAHVIKDIQF 115
T + + C PGY G P SI CL N W+ ++ C+ SC P P NG + +
Sbjct: 2719 TKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNK-IGTQTSY 2777
Query: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
S ++C G+ L+GS+ C+ SG +W C CG+P I NG + E
Sbjct: 2778 GSTAIFTCDLGFMLVGSAVRECLSSG---LWSESETRCLAGHCGIPELIVNGQ---VIGE 2831
Query: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235
+ Y V Y CN G F L+G C + WSG P C+ P C P
Sbjct: 2832 NYGYRDTVVYQCNPG------FRLIGSSVRICQQDHN----WSGQLPSCV-PVSCGHPG- 2879
Query: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV-CQPPPD 294
+ I + + F+ N+VV F C G+ M+GP+ +CQA +W P C V C P
Sbjct: 2880 -SPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGI 2938
Query: 295 VLHAERTQR-DKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDF 353
+++R + + NF+ G VFY C PGY L GS+ L C P G W P C + C
Sbjct: 2939 PANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGH- 2997
Query: 354 LGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE---R 410
+P VL G+ V + C L G S+ C L G W+ S P C
Sbjct: 2998 -PGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDAT 3053
Query: 411 KSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPIC 470
+C P P +G ++ S + Y+C TG+ L G C+ +G+ W+ + P C
Sbjct: 3054 GTCGDPGTPGHGS-RQESNFRTKSTVRYACDTGYILHGSEERTCLANGS---WTGRQPEC 3109
Query: 471 QQIFCPNPPAILNG---RHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSE 527
+ + C NP NG R GT + V Y+C M ++ ++R+ +
Sbjct: 3110 KAVQCGNPGTTANGKVFRIDGT-----TFSSSVIYSC-------MEGYILSGPSVRQCT- 3156
Query: 528 PHGNGVWSSPAPRCEL 543
NG WS P C +
Sbjct: 3157 --ANGTWSGTLPNCTI 3170
Score = 195 bits (496), Expect = 8e-50
Identities = 147/503 (29%), Positives = 206/503 (40%), Gaps = 50/503 (9%)
Query: 63 YECRPGYSGRPFSI-ICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKY 121
Y+C PG+ S+ IC ++ W+ C SC +P P+ G F + +
Sbjct: 2841 YQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSG-NGFNFNDVVTF 2899
Query: 122 SCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTS-ISREYFHYG 180
SC GY + G + A C + W + P+C + C P AN S I F YG
Sbjct: 2900 SCNIGYLMQGPTKAQCQANRQ---WSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYG 2956
Query: 181 SVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGIL 240
+VV Y CN G + L G + C G W P P+CI+ + C P V +
Sbjct: 2957 TVVFYDCNPG------YFLFGSSVLICQPN----GQWDKPLPECIMID-CGHPGVPPNAV 3005
Query: 241 VSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSR----VCQPPPDVL 296
+S + ++ V + C + G S CQ W P CS C P
Sbjct: 3006 LSGEK--YTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPG 3063
Query: 297 HAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQ 356
H R + NF V Y+C+ GY L GS C G W+ P C+ C + G
Sbjct: 3064 HGSRQE---SNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGN-PGT 3119
Query: 357 LPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETP 416
NG V + V + C EG+ L G S C G W+ ++P C SC P
Sbjct: 3120 TANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT---WSGTLPNCTIISCGDP 3176
Query: 417 PVPVNGMVHVITDIHVGSRINYSCTTGH--RLIGHSSAECILSGNTAHWSMKPPICQQIF 474
+P NG+ + D VG ++Y C G+ L G C ++G WS P C+ +
Sbjct: 3177 GIPANGLRYG-DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVT 3232
Query: 475 CPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVW 534
CP PP I NGR GT + +G +SY C P + ++F + GNG W
Sbjct: 3233 CPTPPQISNGRLEGT---NFDWGFSISYICSPGYE--LSFPAVLTCV--------GNGTW 3279
Query: 535 SSPAPRCELPVGAGSHDALIVGK 557
S P+C LP G GK
Sbjct: 3280 SGEVPQC-LPKFCGDPGIPAQGK 3301
Score = 171 bits (433), Expect = 2e-42
Identities = 147/496 (29%), Positives = 204/496 (41%), Gaps = 51/496 (10%)
Query: 55 FPIGTYLNYECRPGYSGRPFSI-ICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDI 113
F GT + Y+C PGY S+ IC N W +C C +P P N + K
Sbjct: 2953 FTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEK-Y 3011
Query: 114 QFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCD---RIICGLPPTIANGDFT 170
F S + YSC L+G SS TC ++G+ W P C CG P T +G
Sbjct: 3012 TFGSTVHYSCTGKRSLLGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPGTPGHG--- 3065
Query: 171 SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKC 230
S F S V Y C+ G + L G C + G W+G P+C
Sbjct: 3066 SRQESNFRTKSTVRYACDTG------YILHGSEERTCLAN----GSWTGRQPECKAVQCG 3115
Query: 231 TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQ 290
P NG + + + FS + V + C G+ + GPS +C A W LP+C+ +
Sbjct: 3116 NPGTTANGKVFRIDGTTFSSS--VIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISC 3173
Query: 291 PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY--DLRGSTYLHCTPQGDWSPAAPRCEVK 348
P + R D++ GQ V Y C+PGY +L GS CT G WS P C
Sbjct: 3174 GDPGI--PANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV 3231
Query: 349 SCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 408
+C Q+ NG L N G + ++C G++L + CV G W+ VP C
Sbjct: 3232 TCPT-PPQISNGR-LEGTNFDWGFSISYICSPGYELSFPAVLTCVGNG---TWSGEVPQC 3286
Query: 409 ERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPP 468
K C P +P G + I+ S +++SC L+G S+ C G WS P
Sbjct: 3287 LPKFCGDPGIPAQGKREGKSFIY-QSEVSFSCNFPFILVGSSTRICQADGT---WSGSSP 3342
Query: 469 IC---QQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRT 525
C Q C NP +G T +G +V H +G +L+ ST RT
Sbjct: 3343 HCIEPTQTSCENPGVPRHGSQNNT------FGFQVGSVVQFHCKKG---HLLQGST-TRT 3392
Query: 526 SEPHGNGVWSSPAPRC 541
P + WS P C
Sbjct: 3393 CLP--DLTWSGIQPEC 3406
Score = 160 bits (405), Expect = 3e-39
Identities = 122/398 (30%), Positives = 166/398 (41%), Gaps = 30/398 (7%)
Query: 78 CLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATC 137
CL N WT + +CK C NP NG I F S + YSC +GY L G S C
Sbjct: 3096 CLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQC 3155
Query: 138 IISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVF 197
+G W P C I CG P ANG +Y G V+Y C G
Sbjct: 3156 TANGT---WSGTLPNCTIISCGDPGIPANG--LRYGDDYV-VGQNVSYMCQPG----YTM 3205
Query: 198 ELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFR 257
EL G CT G WSG P C TPP + NG L N F + +
Sbjct: 3206 ELNGSRIRTCTIN----GTWSGVMPTCRAVTCPTPPQISNGRLEGTN---FDWGFSISYI 3258
Query: 258 CQPGFGMKGPSHVKCQALNKWEPELPSC-SRVCQPPPDVLHAERTQRDKDNFSPGQEVFY 316
C PG+ + P+ + C W E+P C + C P + +R+ +F EV +
Sbjct: 3259 CSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPG---IPAQGKREGKSFIYQSEVSF 3315
Query: 317 SCEPGYDLRGSTYLHCTPQGDWSPAAPRC---EVKSCDDFLGQLPNGHVLFPLNLQLGAK 373
SC + L GS+ C G WS ++P C SC++ G +G Q+G+
Sbjct: 3316 SCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCEN-PGVPRHGSQNNTFGFQVGSV 3374
Query: 374 VDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG 433
V F C +G L+GS+ C+ + W+ P C SC+ P P + V + G
Sbjct: 3375 VQFHCKKGHLLQGSTTRTCL---PDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHG 3431
Query: 434 SRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQ 471
+ Y+C G L G + S NT W+ K PIC+
Sbjct: 3432 YTLIYTCQPGFFLAGGTEHRVCRSDNT--WTGKVPICE 3467
Score = 159 bits (403), Expect = 5e-39
Identities = 133/464 (28%), Positives = 193/464 (41%), Gaps = 60/464 (12%)
Query: 96 CRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISG-NTVIWDNKTPVCD 154
C P P +G Q S ++++C +G+RL+G SSA C S WD P C
Sbjct: 2569 CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQ 2628
Query: 155 RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSR--GKKVFELVGEPSIYCTSKDD 212
I CG+P NG ++ +Y G+ VTY CN G R K++ V C S
Sbjct: 2629 AISCGIPKAPTNGGI--LTTDYL-VGTRVTYFCNDGYRLSSKELTTAV------CQSD-- 2677
Query: 213 QVGIWS--GPAPQCIIPNKCTPPNVENGILVSD-----NRSLFSLNEVVEFRCQPGFGMK 265
G WS P+C++ T P++ + IL N S + V F C PG+
Sbjct: 2678 --GTWSNHNKTPRCVV---VTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGL 2732
Query: 266 GPSHVKC--QALNKWEPELP-----SCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSC 318
GP+ ++C W E P SC + PP +T S G ++C
Sbjct: 2733 GPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQT-------SYGSTAIFTC 2785
Query: 319 EPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVC 378
+ G+ L GS C G WS + RC C + NG V+ N V + C
Sbjct: 2786 DLGFMLVGSAVRECLSSGLWSESETRCLAGHC-GIPELIVNGQVIGE-NYGYRDTVVYQC 2843
Query: 379 DEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINY 438
+ GF+L GSS C + W+ +P C SC P P+ G + + +
Sbjct: 2844 NPGFRLIGSSVRIC---QQDHNWSGQLPSCVPVSCGHPGSPIYGRTSG-NGFNFNDVVTF 2899
Query: 439 SCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNG-RHTGTPLGDIPYG 497
SC G+ + G + A+C + WS PP+C+ + C +P N R + G+ YG
Sbjct: 2900 SCNIGYLMQGPTKAQCQAN---RQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYG 2956
Query: 498 KEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
V Y C+P + L G S + +P NG W P P C
Sbjct: 2957 TVVFYDCNP------GYFLFGSSVL--ICQP--NGQWDKPLPEC 2990
Score = 132 bits (331), Expect = 1e-30
Identities = 154/606 (25%), Positives = 225/606 (37%), Gaps = 115/606 (18%)
Query: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYS--GRPFSIICLKNS----VWTSAK 88
C+ PE P + T + + + + C G+ G+ S +C K+S W +
Sbjct: 2569 CSTPESPPHGYIISQTGG---QLNSVVRWACDRGFRLVGKS-SAVCRKSSYGYHAWDAPV 2624
Query: 89 DKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCII-SGNTVIWD 147
C+ SC P P NG + D +++ Y C GYRL T + S T
Sbjct: 2625 PACQAISCGIPKAPTNG-GILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNH 2683
Query: 148 NKTPVCDRIICGLPPTI-----ANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGE 202
NKTP C + C P+I +G + ++ ++ Y + V + C+ G G +G
Sbjct: 2684 NKTPRCVVVTC---PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHG------LGP 2734
Query: 203 PSIYCTSKDDQVGIWSGPAPQCIIPNKC----TPPN-----------------VENGILV 241
SI C + W P C I + C TPPN + G ++
Sbjct: 2735 ASIECL--PNGTWSWRNERPYCQIIS-CGELPTPPNGNKIGTQTSYGSTAIFTCDLGFML 2791
Query: 242 ----------------SDNRSL-------------------FSLNEVVEFRCQPGFGMKG 266
S+ R L + + V ++C PGF + G
Sbjct: 2792 VGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIG 2851
Query: 267 PSHVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLR 325
S CQ + W +LPSC V C P ++ RT + NF+ V +SC GY ++
Sbjct: 2852 SSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYG-RTSGNGFNFN--DVVTFSCNIGYLMQ 2908
Query: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDD--FLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQ 383
G T C WS P C+V +C D + N G V + C+ G+
Sbjct: 2909 GPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYF 2968
Query: 384 LKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTG 443
L GSS C G W+ +P C C P VP N ++ GS ++YSCT
Sbjct: 2969 LFGSSVLICQPNGQ---WDKPLPECIMIDCGHPGVPPNAVLSG-EKYTFGSTVHYSCTGK 3024
Query: 444 HRLIGHSSAECILSGNTAHWSMKPPICQ---QIFCPNPPAILNGRHTGTPLGDIPYGKEV 500
L+G SS C L+G HWS P C C +P H + V
Sbjct: 3025 RSLLGQSSRTCQLNG---HWSGSQPHCSGDATGTCGDPG---TPGHGSRQESNFRTKSTV 3078
Query: 501 SYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVGAGSHDALIVGKFYE 560
Y CD I + RT NG W+ P C+ V G+ GK +
Sbjct: 3079 RYACDT--------GYILHGSEERTC--LANGSWTGRQPECK-AVQCGNPGTTANGKVFR 3127
Query: 561 VFAEEF 566
+ F
Sbjct: 3128 IDGTTF 3133
Score = 127 bits (319), Expect = 3e-29
Identities = 107/361 (29%), Positives = 142/361 (39%), Gaps = 40/361 (11%)
Query: 63 YECRPGY--SGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIK 120
Y C GY SG P C N W+ C SC +P P NG+ + D +
Sbjct: 3139 YSCMEGYILSG-PSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYG-DDYVVGQNVS 3196
Query: 121 YSCPKGY--RLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFH 178
Y C GY L GS TC I+G W P C + C PP I+NG + F
Sbjct: 3197 YMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVTCPTPPQISNGRLEGTN---FD 3250
Query: 179 YGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENG 238
+G ++Y C+ G +EL + C G WSG PQC+ P C P G
Sbjct: 3251 WGFSISYICSPG------YELSFPAVLTCVGN----GTWSGEVPQCL-PKFCGDP----G 3295
Query: 239 ILVSDNRS--LFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSC----SRVCQPP 292
I R F V F C F + G S CQA W P C C+ P
Sbjct: 3296 IPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENP 3355
Query: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDD 352
H +Q + F G V + C+ G+ L+GST C P WS P C SC
Sbjct: 3356 GVPRHG--SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQ 3413
Query: 353 FLGQLPNGHVLFPLNLQL-GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERK 411
+ P + ++L G + + C GF L G + + ++ W VP+CE
Sbjct: 3414 --PETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR--VCRSDNTWTGKVPICEAG 3469
Query: 412 S 412
S
Sbjct: 3470 S 3470
Score = 113 bits (283), Expect = 4e-25
Identities = 88/304 (28%), Positives = 125/304 (41%), Gaps = 29/304 (9%)
Query: 54 EFPIGTYLNYECRPGYS---GRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVI 110
++ +G ++Y C+PGY+ C N W+ C+ +C PP NG
Sbjct: 3188 DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEG- 3246
Query: 111 KDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFT 170
+ + I Y C GY L + TC+ +G W + P C CG P A G
Sbjct: 3247 TNFDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCLPKFCGDPGIPAQGKRE 3303
Query: 171 SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNK- 229
S F Y S V++ CN F LVG + C + G WSG +P CI P +
Sbjct: 3304 GKS---FIYQSEVSFSCNF------PFILVGSSTRICQAD----GTWSGSSPHCIEPTQT 3350
Query: 230 -CTPPNV-ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSC-S 286
C P V +G +N F + VV+F C+ G ++G + C W P C
Sbjct: 3351 SCENPGVPRHG--SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIP 3408
Query: 287 RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGST-YLHCTPQGDWSPAAPRC 345
C+ P HA D S G + Y+C+PG+ L G T + C W+ P C
Sbjct: 3409 HSCKQPETPAHANVVGMDLP--SHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC 3466
Query: 346 EVKS 349
E S
Sbjct: 3467 EAGS 3470
Score = 85.9 bits (211), Expect = 9e-17
Identities = 124/506 (24%), Positives = 183/506 (36%), Gaps = 96/506 (18%)
Query: 94 KSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVC 153
+SC +P NG + D I + C GY LIG+S+ TC+ G + W++ P C
Sbjct: 2222 QSCPDPRPFRNGFV-IGNDFTVGQTISFECFPGYTLIGNSALTCL-HGVSRNWNHPLPRC 2279
Query: 154 DRIICGLPPTIANGDFTS--ISREYFHYGSVVTYHCNLGSRGKKV-FELVGEPSIYCTSK 210
+ + CG T NG S EY ++ G + F ++ IY
Sbjct: 2280 EAL-CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIY---- 2334
Query: 211 DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHV 270
D + +W GP P + + S++S + + + F G +
Sbjct: 2335 -DFITVWDGPDQNS--------PQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVL 2385
Query: 271 KCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYL 330
A RVCQPPP V +AE D D F G + Y C PG+ L G+ L
Sbjct: 2386 SYHAYQL---------RVCQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFTLVGNAIL 2435
Query: 331 HCT--PQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFP------LNLQLGAKVDFVCDEGF 382
C + A P C+V + L G +L P NLQ+ A ++G+
Sbjct: 2436 TCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCA-WSISVEKGY 2494
Query: 383 QL-------------------KGSSASYCVLAGMESLWNSSVPVCERKS----------- 412
+ G + VL + ++S+ +
Sbjct: 2495 NITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHG 2554
Query: 413 --------------CETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSG 458
C TP P +G + T + S + ++C G RL+G SSA C S
Sbjct: 2555 NNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSS 2614
Query: 459 NTAH-WSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLI 517
H W P CQ I C P A NG G D G V+Y C+ + L
Sbjct: 2615 YGYHAWDAPVPACQAISCGIPKAPTNG---GILTTDYLVGTRVTYFCND------GYRL- 2664
Query: 518 GESTIRRTSEPHGNGVWS--SPAPRC 541
S T+ +G WS + PRC
Sbjct: 2665 -SSKELTTAVCQSDGTWSNHNKTPRC 2689
Score = 67.4 bits (163), Expect = 3e-11
Identities = 97/432 (22%), Positives = 157/432 (36%), Gaps = 76/432 (17%)
Query: 93 RKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGN-TVIWDNKTP 151
R+SC +P + +NG + D + S + Y C GY L G S+ TCI+ + W+ P
Sbjct: 1698 RESCFDPGNIMNG-TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1756
Query: 152 VCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKD 211
C CG T + G T +S Y SV ++C K F + G+ + TS
Sbjct: 1757 SC-HAPCGSRSTGSEG--TVLSPNYPKNYSV-GHNCVYSIAVPKEFVVFGQFVFFQTSLH 1812
Query: 212 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVK 271
D V ++ GP Q + + + + + +S + + F KG H
Sbjct: 1813 DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQI-----TIRFTSVGPITAKG-FHFV 1866
Query: 272 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLH 331
QA+ + CS V +P +R + F+ G V + C PGY L GS +
Sbjct: 1867 YQAVPRTSST--QCSSVPEP-------RFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIR 1917
Query: 332 C----TPQGDWSPAAPRCEVKSCDDFL----GQLPNGHVLFPLNLQLGAKVDFVCDEGFQ 383
C W+ + P C + C L G + + P + L EG
Sbjct: 1918 CETVPNSLAQWNDSLPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAG 1976
Query: 384 LKGSSASYCVLAGMESL-----WNSSVPVCERKSCETPPVPVNGMVHVI----------- 427
++ S+ +SL +++ P S T P +N + +
Sbjct: 1977 IQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVS 2036
Query: 428 -----------------------TDIHVGSR------INYSCTTGHRLIGHSSAECILSG 458
+ I +G R +++ C G+ L GHS C + G
Sbjct: 2037 AAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITC-MPG 2095
Query: 459 NTAHWSMKPPIC 470
W+ PIC
Sbjct: 2096 PVRRWNYPIPIC 2107
Score = 58.2 bits (139), Expect = 2e-08
Identities = 107/470 (22%), Positives = 157/470 (33%), Gaps = 101/470 (21%)
Query: 61 LNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIK 120
L ++ SGR F+I + C +P P+N + Q S I
Sbjct: 809 LEFQADHSMSGRGFNI----------TYNTFGHNECPDPGIPINARRFG-DNFQLGSSIS 857
Query: 121 YSCPKGY-RLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHY 179
C +G+ + G+ + TCI+ V+W P C G P G F++ S
Sbjct: 858 VICEEGFIKTQGTETITCILMDGKVMWSGLIPKC-----GAP---CGGHFSAPSGVILSP 909
Query: 180 GSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPP-NVENG 238
G Y +L V E SI T + Q + PN +P NG
Sbjct: 910 GWPGYYKDSLNCEW--VIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNG 967
Query: 239 -----ILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPP 293
L S + ++ L R GF + H + +N + C P
Sbjct: 968 TQVPQFLFSSSNFIYLLFTTDNSRSNNGFKI----HYESVTVNTYS---------CLDPG 1014
Query: 294 DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDF 353
+H R D FS G V +SC+ GY L L C WS P C+ D
Sbjct: 1015 IPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDV 1071
Query: 354 LGQLPNGHVL-------FPLNLQLGAKVDFVCDEGFQ----------------------- 383
G P+G +L +P +L VD +G Q
Sbjct: 1072 RG--PSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSF 1129
Query: 384 ------LKGSSASYCVLAGMESL-----------------WNSSVPVCERKSCETPPVPV 420
L GS + AG+ +N + + CE P +P
Sbjct: 1130 TQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQ 1189
Query: 421 NGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPIC 470
G + + +G + +SC++G+RL G S C L G WS P C
Sbjct: 1190 YGS-RIGFNFGIGDTLTFSCSSGYRLEGTSEIIC-LGGGRRVWSAPLPRC 1237
Score = 57.0 bits (136), Expect = 5e-08
Identities = 102/442 (23%), Positives = 157/442 (35%), Gaps = 59/442 (13%)
Query: 117 SQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREY 176
S I Y C GY L GSS C+ +G WD P C G ++G S
Sbjct: 1375 STIIYGCNPGYTLHGSSLLKCM-TGERRAWDYPLPSCIAECGGRFKGESSGRILSP---- 1429
Query: 177 FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKD-----DQVGIWSGPAPQCIIPNKCT 231
G Y NL + S+ + D D + +W GP ++ + +
Sbjct: 1430 ---GYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDMLLKEIS 1486
Query: 232 PPNVENGILVSDNRSLFSLNEVVEFRC-QPGFGMKGPSHVKCQALNKWEPELPSCSRVCQ 290
+ GI + N + ++ +F + GF ++ S V + C+
Sbjct: 1487 GSLIPEGIHSTLN--IVTIQFDTDFYISKSGFAIQFSSSV---------------ATACR 1529
Query: 291 PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGD---WSPAAPRCEV 347
P ++ R + D PG V + C+PGY+L+G + C + W P+ P C
Sbjct: 1530 DPGVPMNGTR---NGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA 1586
Query: 348 KSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPV 407
+ G +G +L P N CD + +A Y + S S P
Sbjct: 1587 PCGGNLTGS--SGFILSP-NFPHPYPHSRDCDWTITV---NADYVISLAFISF--SIEPN 1638
Query: 408 CERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKP 467
+ P + ++ D + RI S T H L S +G H K
Sbjct: 1639 YDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMH-LAFRSDGSVSYTG--FHLEYKA 1695
Query: 468 PICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSE 527
+ + C +P I+NG G D G V+Y CD + L G ST+
Sbjct: 1696 KLRES--CFDPGNIMNGTRLGM---DYKLGSTVTYYCD------AGYVLQGYSTLTCIMG 1744
Query: 528 PHGNGVWSSPAPRCELPVGAGS 549
G W+ P C P G+ S
Sbjct: 1745 DDGRPGWNRALPSCHAPCGSRS 1766
Score = 53.1 bits (126), Expect = 7e-07
Identities = 106/477 (22%), Positives = 159/477 (33%), Gaps = 60/477 (12%)
Query: 80 KNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATC-I 138
K S+ K C +P +P NG + D S +++SC + Y L G+ S TC
Sbjct: 470 KFSILNEGGIKTASNLCPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQR 528
Query: 139 ISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFE 198
I+ W + PVC CG +G FTS + + + + KV +
Sbjct: 529 IAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQ 588
Query: 199 LVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRC 258
+ E D + I G + + T V G V D S + +
Sbjct: 589 INFE-EFDLEIGYDTLTIGDGGE----VGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQT 643
Query: 259 QPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSC 318
G G +N E E SC P + R+ D FS + + C
Sbjct: 644 DESVGSVG------FKVNYKEIEKESCGDPGTPLYGI-------REGDGFSNRDVLRFEC 690
Query: 319 EPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFP-----LNLQLGAK 373
+ G++L G + C WS P C +F P G VL P L
Sbjct: 691 QFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTA--PMGTVLSPDYPEGYGNNLNCI 748
Query: 374 VDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG 433
+ D G ++ S + + S K ++P P+ G T V
Sbjct: 749 WTIISDPGSRIHLSFNDFDL--------ESQFDFLAVKDGDSPESPILG---TFTGAEVP 797
Query: 434 SRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIF----CPNPPAILNGRHTGT 489
S + + H L A+ +SG + I F CP+P +N R G
Sbjct: 798 SHLT---SNSHILRLEFQADHSMSGRGFN------ITYNTFGHNECPDPGIPINARRFG- 847
Query: 490 PLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVG 546
+ G +S C+ G TI G +WS P+C P G
Sbjct: 848 --DNFQLGSSISVICEEG-----FIKTQGTETI-TCILMDGKVMWSGLIPKCGAPCG 896
Score = 52.8 bits (125), Expect = 9e-07
Identities = 28/64 (43%), Positives = 35/64 (54%), Gaps = 2/64 (3%)
Query: 409 ERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECIL-SGNTAHWSMKP 467
+ SC P VP G+++ T VG +I YSC TG+ L GH CI S NTA W
Sbjct: 174 QSSSCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPV 232
Query: 468 PICQ 471
PIC+
Sbjct: 233 PICR 236
Score = 46.6 bits (109), Expect = 6e-05
Identities = 95/434 (21%), Positives = 144/434 (33%), Gaps = 90/434 (20%)
Query: 95 SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCD 154
SC +P PV+G + D S + +SC GYRL C W + P CD
Sbjct: 1009 SCLDPGIPVHGRRYG-HDFSIGSTVSFSCDSGYRLSHEEPLLC---EKNHWWSHPLPTCD 1064
Query: 155 RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKV------FELVGEPSIYCT 208
+ CG +G S F+ S+ + GK V F L
Sbjct: 1065 AL-CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLI 1123
Query: 209 SKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEV-VEFRCQPGFGMKGP 267
+++ S P + PP + G+ + L +++ + + GF +
Sbjct: 1124 TENG-----SFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYE---GFNITFS 1175
Query: 268 SHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGS 327
+ EP C+ P + R NF G + +SC GY L G+
Sbjct: 1176 EY-------NLEP--------CEDPGIPQYGSRIGF---NFGIGDTLTFSCSSGYRLEGT 1217
Query: 328 TYLHCTPQGD--WSPAAPRCEVK-------------SCDDFLGQLPNGHVLFPLNLQLGA 372
+ + C G WS PRC + S + L N ++ + +Q G
Sbjct: 1218 SEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGK 1277
Query: 373 KVD-----FVCDEGFQLK----------------GSSASYCVLAGMES-LW---NSSVPV 407
++ F +G LK G+S L+ + LW NS
Sbjct: 1278 GINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEG 1337
Query: 408 C-----------ERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECIL 456
E CE P +P G GS I Y C G+ L G S +C +
Sbjct: 1338 TDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKC-M 1396
Query: 457 SGNTAHWSMKPPIC 470
+G W P C
Sbjct: 1397 TGERRAWDYPLPSC 1410
Score = 43.9 bits (102), Expect = 4e-04
Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 2/66 (3%)
Query: 89 DKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCII-SGNTVIWD 147
++ + SC NP P G+ + + +I+YSC GY L G TCI S NT WD
Sbjct: 171 EELQSSSCGNPGVPPKGVLYGTR-FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWD 229
Query: 148 NKTPVC 153
P+C
Sbjct: 230 FPVPIC 235
Score = 40.8 bits (94), Expect = 0.003
Identities = 104/467 (22%), Positives = 167/467 (35%), Gaps = 76/467 (16%)
Query: 96 CRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVI-WDNKTPVCD 154
C + P+P G + + S + + C GY L GS + C N++ W++ P C
Sbjct: 1878 CSSVPEPRFGR-RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCI 1936
Query: 155 RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGK-KVFELVG---EPSIYCTSK 210
+ CG G T G Y NL K V E G + + T
Sbjct: 1937 -VPCG-------GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH 1988
Query: 211 D-DQVGIWSGP---APQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKG 266
+ D + + G AP+ + T P++ N S N + F+ G
Sbjct: 1989 NWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNST---------SNNLYLNFQSDISVSAAG 2039
Query: 267 PSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG 326
H++ A+ L SC P + + D + G V + C+ GY L+G
Sbjct: 2040 -FHLEYTAIG-----LDSCPEPQTPSSGI-------KIGDRYMVGDVVSFQCDQGYSLQG 2086
Query: 327 STYLHCTPQG--DWSPAAPRCEVK---SCDDFLGQL--PNGHVLFPLNLQLGAKVDFVCD 379
+++ C P W+ P C + + DF G + P +P +L ++
Sbjct: 2087 HSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIG 2146
Query: 380 EGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYS 439
G L+ + S + + + S ET V + ++ + S + +S
Sbjct: 2147 FGVHLQFVNFSTETIHDYLEVRSGS--------SETSTV-----IGRLSGPQIPSSL-FS 2192
Query: 440 CTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKE 499
T L HS S N + + Q CP+P NG G D G+
Sbjct: 2193 TTHETSLYFHSD----YSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGN---DFTVGQT 2245
Query: 500 VSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVG 546
+S+ C P + LIG S + N W+ P PRCE G
Sbjct: 2246 ISFECFPG------YTLIGNSALTCLHGVSRN--WNHPLPRCEALCG 2284
Score = 40.4 bits (93), Expect = 0.004
Identities = 63/274 (22%), Positives = 101/274 (36%), Gaps = 30/274 (10%)
Query: 96 CRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDR 155
C +P P G + + + + +SC GYRL G+S C+ G V W P C
Sbjct: 1182 CEDPGIPQYG-SRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRV-WSAPLPRCVA 1239
Query: 156 IICGLPPTIANGDFTSISREY-FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQV 214
CG T N + +S Y +Y + + C + + + + ++ D +
Sbjct: 1240 E-CGASAT--NNEGILLSPNYPLNYEN--NHECIYSIQVQAGKGINISARTFHLAQGDVL 1294
Query: 215 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLF-SLNEVVEFRCQPGFGMKGPSHVKCQ 273
I+ G + T ++ L S + L+ N E GF + S
Sbjct: 1295 KIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTE-GTDEGFQLVYTSF---- 1349
Query: 274 ALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCT 333
EL C P + D+ +F+ G + Y C PGY L GS+ L C
Sbjct: 1350 -------ELSHCE-----DPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCM 1396
Query: 334 --PQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFP 365
+ W P C + F G+ +G +L P
Sbjct: 1397 TGERRAWDYPLPSCIAECGGRFKGE-SSGRILSP 1429
Score = 37.7 bits (86), Expect = 0.029
Identities = 67/302 (22%), Positives = 102/302 (33%), Gaps = 53/302 (17%)
Query: 228 NKCTPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGF-GMKGPSHVKCQALN---KWEPEL 282
N+C P + N DN F L + C+ GF +G + C ++ W +
Sbjct: 832 NECPDPGIPINARRFGDN---FQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLI 888
Query: 283 PSCSRVC----QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDW 338
P C C P V+ SPG +Y L + P
Sbjct: 889 PKCGAPCGGHFSAPSGVI-----------LSPGWPGYYKDS----LNCEWVIEAEPGHSI 933
Query: 339 SPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 398
R + + D L ++L PL LG+ + F S+ Y +
Sbjct: 934 KITFERFQTELNYDVLEVHDGPNLLSPL---LGSYNGTQVPQ-FLFSSSNFIYLLFTTDN 989
Query: 399 SLWNSSVPV------CERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSA 452
S N+ + SC P +PV+G + D +GS +++SC +G+RL S
Sbjct: 990 SRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYG-HDFSIGSTVSFSCDSGYRL---SHE 1045
Query: 453 ECILSGNTAHWSMKPPICQ------------QIFCPNPPAILNGRHTGTPLGDIPYGKEV 500
E +L WS P C I P P T D+ +GK V
Sbjct: 1046 EPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGV 1105
Query: 501 SY 502
+
Sbjct: 1106 QF 1107
Score = 37.0 bits (84), Expect = 0.049
Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 1/59 (1%)
Query: 95 SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVC 153
+CR+P P+NG + + + + C GY L G TCI N W PVC
Sbjct: 1527 ACRDPGVPMNGTRNG-DGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1584
Score = 33.9 bits (76), Expect = 0.41
Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 4/80 (5%)
Query: 346 EVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 405
+++SC D NG V+ + +G + F C G+ L G+SA C L G+ WN +
Sbjct: 2220 QLQSCPD-PRPFRNGFVIGN-DFTVGQTISFECFPGYTLIGNSALTC-LHGVSRNWNHPL 2276
Query: 406 PVCERKSCETPPVPVNGMVH 425
P CE C +NG ++
Sbjct: 2277 PRCE-ALCGGNITAMNGTIY 2295
Score = 32.3 bits (72), Expect = 1.2
Identities = 22/74 (29%), Positives = 27/74 (36%), Gaps = 11/74 (14%)
Query: 279 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQ--- 335
E + SC PP VL+ R F G ++ YSC GY L G L C
Sbjct: 172 ELQSSSCGNPGVPPKGVLYGTR-------FDVGDKIRYSCVTGYILDGHPQLTCIANSVN 224
Query: 336 -GDWSPAAPRCEVK 348
W P C +
Sbjct: 225 TASWDFPVPICRAE 238
Score = 31.2 bits (69), Expect = 2.7
Identities = 15/36 (41%), Positives = 21/36 (58%), Gaps = 2/36 (5%)
Query: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYS 70
C P +P A LT+D EF IG + Y+C PG++
Sbjct: 2395 CQPPPPVPNAEI--LTEDDEFEIGDIIRYQCLPGFT 2428
Score = 29.6 bits (65), Expect = 7.8
Identities = 14/53 (26%), Positives = 25/53 (47%), Gaps = 1/53 (1%)
Query: 357 LPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL-WNSSVPVC 408
+P VL+ +G K+ + C G+ L G C+ + + W+ VP+C
Sbjct: 183 VPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 235
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 197 bits (502), Expect = 2e-50
Identities = 153/525 (29%), Positives = 225/525 (42%), Gaps = 67/525 (12%)
Query: 35 CNVPEWLPFARPTN---LTDDFEFPIGTYLNYECRPGY---SGRPFSIICLKNSVWTSAK 88
C +P+ PTN LT D+ +GT + Y C GY S + +C + W++
Sbjct: 2528 CGIPK-----APTNGGILTTDYL--VGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHN 2580
Query: 89 D--KCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIW 146
+C SC P P NG + + S ++C G+ L+GS+ C+ SG +W
Sbjct: 2581 KTPRCVVISCGELPTPPNGNK-IGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSG---LW 2636
Query: 147 DNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIY 206
C CG+P I NG + E + Y V Y CN G F L+G
Sbjct: 2637 SESETRCLAGHCGIPELIVNGQ---VIGENYGYRDTVVYQCNPG------FRLIGSSVRI 2687
Query: 207 CTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKG 266
C + WSG P C+ P C P + I + + F+ N+VV F C G+ M+G
Sbjct: 2688 CQQDHN----WSGQLPSCV-PVSCGHPG--SPIYGRTSGNGFNFNDVVTFSCNIGYLMQG 2740
Query: 267 PSHVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQR-DKDNFSPGQEVFYSCEPGYDL 324
P+ +CQA +W P C V C P +++R + + NF+ G VFY C PGY L
Sbjct: 2741 PTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFL 2800
Query: 325 RGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQL 384
GS+ L C P G W P C + C +P VL G+ V + C L
Sbjct: 2801 FGSSVLICQPNGQWDKPLPECIMIDCGH--PGVPPNAVLSGEKYTFGSTVHYSCTGKRSL 2858
Query: 385 KGSSASYCVLAGMESLWNSSVPVCE---RKSCETPPVPVNGMVHVITDIHVGSRINYSCT 441
G S+ C L G W+ S P C +C P P +G ++ S + Y+C
Sbjct: 2859 LGQSSRTCQLNGH---WSGSQPHCSGDATGTCGDPGTPGHGS-RQESNFRTKSTVRYACD 2914
Query: 442 TGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNG---RHTGTPLGDIPYGK 498
TG+ L G C+ +G+ W+ + P C+ + C NP NG R GT +
Sbjct: 2915 TGYILHGSEERTCLANGS---WTGRQPECKAVQCGNPGTTANGKVFRIDGT-----TFSS 2966
Query: 499 EVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
V Y+C M ++ ++R+ + NG WS P C +
Sbjct: 2967 SVIYSC-------MEGYILSGPSVRQCT---ANGTWSGTLPNCTI 3001
Score = 195 bits (496), Expect = 8e-50
Identities = 147/503 (29%), Positives = 206/503 (40%), Gaps = 50/503 (9%)
Query: 63 YECRPGYSGRPFSI-ICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKY 121
Y+C PG+ S+ IC ++ W+ C SC +P P+ G F + +
Sbjct: 2672 YQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSG-NGFNFNDVVTF 2730
Query: 122 SCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTS-ISREYFHYG 180
SC GY + G + A C + W + P+C + C P AN S I F YG
Sbjct: 2731 SCNIGYLMQGPTKAQCQANRQ---WSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYG 2787
Query: 181 SVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGIL 240
+VV Y CN G + L G + C G W P P+CI+ + C P V +
Sbjct: 2788 TVVFYDCNPG------YFLFGSSVLICQPN----GQWDKPLPECIMID-CGHPGVPPNAV 2836
Query: 241 VSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSR----VCQPPPDVL 296
+S + ++ V + C + G S CQ W P CS C P
Sbjct: 2837 LSGEK--YTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPG 2894
Query: 297 HAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQ 356
H R + NF V Y+C+ GY L GS C G W+ P C+ C + G
Sbjct: 2895 HGSRQE---SNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGN-PGT 2950
Query: 357 LPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETP 416
NG V + V + C EG+ L G S C G W+ ++P C SC P
Sbjct: 2951 TANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT---WSGTLPNCTIISCGDP 3007
Query: 417 PVPVNGMVHVITDIHVGSRINYSCTTGH--RLIGHSSAECILSGNTAHWSMKPPICQQIF 474
+P NG+ + D VG ++Y C G+ L G C ++G WS P C+ +
Sbjct: 3008 GIPANGLRYG-DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVT 3063
Query: 475 CPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVW 534
CP PP I NGR GT + +G +SY C P + ++F + GNG W
Sbjct: 3064 CPTPPQISNGRLEGT---NFDWGFSISYICSPGYE--LSFPAVLTCV--------GNGTW 3110
Query: 535 SSPAPRCELPVGAGSHDALIVGK 557
S P+C LP G GK
Sbjct: 3111 SGEVPQC-LPKFCGDPGIPAQGK 3132
Score = 179 bits (454), Expect = 6e-45
Identities = 144/499 (28%), Positives = 200/499 (40%), Gaps = 51/499 (10%)
Query: 55 FPIGTYLNYECRPGYSGR-PFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKD- 112
F + + C GY + P C N W+ CK +C +P P N +
Sbjct: 2722 FNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEH 2781
Query: 113 --IQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFT 170
+ + + Y C GY L GSS C +G WD P C I CG P N
Sbjct: 2782 GNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQ---WDKPLPECIMIDCGHPGVPPNA--- 2835
Query: 171 SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCI--IPN 228
+S E + +GS V Y C GK+ L+G+ S C G WSG P C
Sbjct: 2836 VLSGEKYTFGSTVHYSCT----GKR--SLLGQSSRTCQLN----GHWSGSQPHCSGDATG 2885
Query: 229 KCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV 288
C P S S F V + C G+ + G C A W P C V
Sbjct: 2886 TCGDPGTPGH--GSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAV 2943
Query: 289 -CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEV 347
C P + + + D FS V YSC GY L G + CT G WS P C +
Sbjct: 2944 QCGNPGTTANGKVFRIDGTTFS--SSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTI 3001
Query: 348 KSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGF--QLKGSSASYCVLAGMESLWNSSV 405
SC D +P + + + +G V ++C G+ +L GS C + G W+ +
Sbjct: 3002 ISCGD--PGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVM 3056
Query: 406 PVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSM 465
P C +C TPP NG + T+ G I+Y C+ G+ L + C+ +G WS
Sbjct: 3057 PTCRAVTCPTPPQISNGRLEG-TNFDWGFSISYICSPGYELSFPAVLTCVGNGT---WSG 3112
Query: 466 KPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRT 525
+ P C FC +P G+ G Y EVS++C+ F L+G ST R
Sbjct: 3113 EVPQCLPKFCGDPGIPAQGKREGK---SFIYQSEVSFSCN------FPFILVGSST--RI 3161
Query: 526 SEPHGNGVWSSPAPRCELP 544
+ +G WS +P C P
Sbjct: 3162 CQ--ADGTWSGSSPHCIEP 3178
Score = 168 bits (425), Expect = 1e-41
Identities = 155/545 (28%), Positives = 219/545 (40%), Gaps = 58/545 (10%)
Query: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYS--GRPFSIICLKNS----VWTSAK 88
C+ PE P + T + + + + C G+ G+ S +C K+S W +
Sbjct: 2465 CSTPESPPHGYIISQTGG---QLNSVVRWACDRGFRLVGKS-SAVCRKSSYGYHAWDAPV 2520
Query: 89 DKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCII-SGNTVIWD 147
C+ SC P P NG + D +++ Y C GYRL T + S T
Sbjct: 2521 PACQAISCGIPKAPTNG-GILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNH 2579
Query: 148 NKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYC 207
NKTP C I CG PT NG+ YGS + C+LG F LVG C
Sbjct: 2580 NKTPRCVVISCGELPTPPNGNKIGTQTS---YGSTAIFTCDLG------FMLVGSAVREC 2630
Query: 208 TSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGP 267
S G+WS +C+ + P + NG ++ +N + + V ++C PGF + G
Sbjct: 2631 LSS----GLWSESETRCLAGHCGIPELIVNGQVIGEN---YGYRDTVVYQCNPGFRLIGS 2683
Query: 268 SHVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG 326
S CQ + W +LPSC V C P ++ RT + NF+ V +SC GY ++G
Sbjct: 2684 SVRICQQDHNWSGQLPSCVPVSCGHPGSPIYG-RTSGNGFNFN--DVVTFSCNIGYLMQG 2740
Query: 327 STYLHCTPQGDWSPAAPRCEVKSCDD--FLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQL 384
T C WS P C+V +C D + N G V + C+ G+ L
Sbjct: 2741 PTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFL 2800
Query: 385 KGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGH 444
GSS C G W+ +P C C P VP N ++ GS ++YSCT
Sbjct: 2801 FGSSVLICQPNGQ---WDKPLPECIMIDCGHPGVPPNAVLSG-EKYTFGSTVHYSCTGKR 2856
Query: 445 RLIGHSSAECILSGNTAHWSMKPPICQ---QIFCPNPPAILNGRHTGTPLGDIPYGKEVS 501
L+G SS C L+G HWS P C C +P H + V
Sbjct: 2857 SLLGQSSRTCQLNG---HWSGSQPHCSGDATGTCGDPG---TPGHGSRQESNFRTKSTVR 2910
Query: 502 YTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVGAGSHDALIVGKFYEV 561
Y CD I + RT NG W+ P C+ V G+ GK + +
Sbjct: 2911 YACDT--------GYILHGSEERTC--LANGSWTGRQPECK-AVQCGNPGTTANGKVFRI 2959
Query: 562 FAEEF 566
F
Sbjct: 2960 DGTTF 2964
Score = 160 bits (405), Expect = 3e-39
Identities = 122/398 (30%), Positives = 166/398 (41%), Gaps = 30/398 (7%)
Query: 78 CLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATC 137
CL N WT + +CK C NP NG I F S + YSC +GY L G S C
Sbjct: 2927 CLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQC 2986
Query: 138 IISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVF 197
+G W P C I CG P ANG +Y G V+Y C G
Sbjct: 2987 TANGT---WSGTLPNCTIISCGDPGIPANG--LRYGDDYV-VGQNVSYMCQPG----YTM 3036
Query: 198 ELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFR 257
EL G CT G WSG P C TPP + NG L N F + +
Sbjct: 3037 ELNGSRIRTCTIN----GTWSGVMPTCRAVTCPTPPQISNGRLEGTN---FDWGFSISYI 3089
Query: 258 CQPGFGMKGPSHVKCQALNKWEPELPSC-SRVCQPPPDVLHAERTQRDKDNFSPGQEVFY 316
C PG+ + P+ + C W E+P C + C P + +R+ +F EV +
Sbjct: 3090 CSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPG---IPAQGKREGKSFIYQSEVSF 3146
Query: 317 SCEPGYDLRGSTYLHCTPQGDWSPAAPRC---EVKSCDDFLGQLPNGHVLFPLNLQLGAK 373
SC + L GS+ C G WS ++P C SC++ G +G Q+G+
Sbjct: 3147 SCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCEN-PGVPRHGSQNNTFGFQVGSV 3205
Query: 374 VDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG 433
V F C +G L+GS+ C+ + W+ P C SC+ P P + V + G
Sbjct: 3206 VQFHCKKGHLLQGSTTRTCL---PDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHG 3262
Query: 434 SRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQ 471
+ Y+C G L G + S NT W+ K PIC+
Sbjct: 3263 YTLIYTCQPGFFLAGGTEHRVCRSDNT--WTGKVPICE 3298
Score = 127 bits (319), Expect = 3e-29
Identities = 107/361 (29%), Positives = 142/361 (39%), Gaps = 40/361 (11%)
Query: 63 YECRPGY--SGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIK 120
Y C GY SG P C N W+ C SC +P P NG+ + D +
Sbjct: 2970 YSCMEGYILSG-PSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYG-DDYVVGQNVS 3027
Query: 121 YSCPKGY--RLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFH 178
Y C GY L GS TC I+G W P C + C PP I+NG + F
Sbjct: 3028 YMCQPGYTMELNGSRIRTCTINGT---WSGVMPTCRAVTCPTPPQISNGRLEGTN---FD 3081
Query: 179 YGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENG 238
+G ++Y C+ G +EL + C G WSG PQC+ P C P G
Sbjct: 3082 WGFSISYICSPG------YELSFPAVLTCVGN----GTWSGEVPQCL-PKFCGDP----G 3126
Query: 239 ILVSDNRS--LFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSC----SRVCQPP 292
I R F V F C F + G S CQA W P C C+ P
Sbjct: 3127 IPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENP 3186
Query: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDD 352
H +Q + F G V + C+ G+ L+GST C P WS P C SC
Sbjct: 3187 GVPRHG--SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQ 3244
Query: 353 FLGQLPNGHVLFPLNLQL-GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERK 411
+ P + ++L G + + C GF L G + + ++ W VP+CE
Sbjct: 3245 --PETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR--VCRSDNTWTGKVPICEAG 3300
Query: 412 S 412
S
Sbjct: 3301 S 3301
Score = 113 bits (283), Expect = 4e-25
Identities = 88/304 (28%), Positives = 125/304 (41%), Gaps = 29/304 (9%)
Query: 54 EFPIGTYLNYECRPGYS---GRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVI 110
++ +G ++Y C+PGY+ C N W+ C+ +C PP NG
Sbjct: 3019 DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEG- 3077
Query: 111 KDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFT 170
+ + I Y C GY L + TC+ +G W + P C CG P A G
Sbjct: 3078 TNFDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCLPKFCGDPGIPAQGKRE 3134
Query: 171 SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNK- 229
S F Y S V++ CN F LVG + C + G WSG +P CI P +
Sbjct: 3135 GKS---FIYQSEVSFSCNF------PFILVGSSTRICQAD----GTWSGSSPHCIEPTQT 3181
Query: 230 -CTPPNV-ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSC-S 286
C P V +G +N F + VV+F C+ G ++G + C W P C
Sbjct: 3182 SCENPGVPRHG--SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIP 3239
Query: 287 RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGST-YLHCTPQGDWSPAAPRC 345
C+ P HA D S G + Y+C+PG+ L G T + C W+ P C
Sbjct: 3240 HSCKQPETPAHANVVGMDLP--SHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC 3297
Query: 346 EVKS 349
E S
Sbjct: 3298 EAGS 3301
Score = 85.9 bits (211), Expect = 9e-17
Identities = 124/506 (24%), Positives = 183/506 (36%), Gaps = 96/506 (18%)
Query: 94 KSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVC 153
+SC +P NG + D I + C GY LIG+S+ TC+ G + W++ P C
Sbjct: 2118 QSCPDPRPFRNGFV-IGNDFTVGQTISFECFPGYTLIGNSALTCL-HGVSRNWNHPLPRC 2175
Query: 154 DRIICGLPPTIANGDFTS--ISREYFHYGSVVTYHCNLGSRGKKV-FELVGEPSIYCTSK 210
+ + CG T NG S EY ++ G + F ++ IY
Sbjct: 2176 EAL-CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIY---- 2230
Query: 211 DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHV 270
D + +W GP P + + S++S + + + F G +
Sbjct: 2231 -DFITVWDGPDQNS--------PQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVL 2281
Query: 271 KCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYL 330
A RVCQPPP V +AE D D F G + Y C PG+ L G+ L
Sbjct: 2282 SYHAYQL---------RVCQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFTLVGNAIL 2331
Query: 331 HCT--PQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFP------LNLQLGAKVDFVCDEGF 382
C + A P C+V + L G +L P NLQ+ A ++G+
Sbjct: 2332 TCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCA-WSISVEKGY 2390
Query: 383 QL-------------------KGSSASYCVLAGMESLWNSSVPVCERKS----------- 412
+ G + VL + ++S+ +
Sbjct: 2391 NITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHG 2450
Query: 413 --------------CETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSG 458
C TP P +G + T + S + ++C G RL+G SSA C S
Sbjct: 2451 NNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSS 2510
Query: 459 NTAH-WSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLI 517
H W P CQ I C P A NG G D G V+Y C+ + L
Sbjct: 2511 YGYHAWDAPVPACQAISCGIPKAPTNG---GILTTDYLVGTRVTYFCND------GYRL- 2560
Query: 518 GESTIRRTSEPHGNGVWS--SPAPRC 541
S T+ +G WS + PRC
Sbjct: 2561 -SSKELTTAVCQSDGTWSNHNKTPRC 2585
Score = 67.4 bits (163), Expect = 3e-11
Identities = 97/432 (22%), Positives = 157/432 (36%), Gaps = 76/432 (17%)
Query: 93 RKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGN-TVIWDNKTP 151
R+SC +P + +NG + D + S + Y C GY L G S+ TCI+ + W+ P
Sbjct: 1594 RESCFDPGNIMNG-TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1652
Query: 152 VCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKD 211
C CG T + G T +S Y SV ++C K F + G+ + TS
Sbjct: 1653 SC-HAPCGSRSTGSEG--TVLSPNYPKNYSV-GHNCVYSIAVPKEFVVFGQFVFFQTSLH 1708
Query: 212 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVK 271
D V ++ GP Q + + + + + +S + + F KG H
Sbjct: 1709 DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQI-----TIRFTSVGPITAKG-FHFV 1762
Query: 272 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLH 331
QA+ + CS V +P +R + F+ G V + C PGY L GS +
Sbjct: 1763 YQAVPRTSST--QCSSVPEP-------RFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIR 1813
Query: 332 C----TPQGDWSPAAPRCEVKSCDDFL----GQLPNGHVLFPLNLQLGAKVDFVCDEGFQ 383
C W+ + P C + C L G + + P + L EG
Sbjct: 1814 CETVPNSLAQWNDSLPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAG 1872
Query: 384 LKGSSASYCVLAGMESL-----WNSSVPVCERKSCETPPVPVNGMVHVI----------- 427
++ S+ +SL +++ P S T P +N + +
Sbjct: 1873 IQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVS 1932
Query: 428 -----------------------TDIHVGSR------INYSCTTGHRLIGHSSAECILSG 458
+ I +G R +++ C G+ L GHS C + G
Sbjct: 1933 AAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITC-MPG 1991
Query: 459 NTAHWSMKPPIC 470
W+ PIC
Sbjct: 1992 PVRRWNYPIPIC 2003
Score = 62.4 bits (150), Expect = 1e-09
Identities = 82/304 (26%), Positives = 126/304 (41%), Gaps = 43/304 (14%)
Query: 89 DKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCII-SGNTVIWD 147
++ + SC NP P G+ + + +I+YSC GY L G TCI S NT WD
Sbjct: 171 EELQSSSCGNPGVPPKGVLYGTR-FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWD 229
Query: 148 NKTPVC-DRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIY 206
P+C CG ++G +S S YH N V E S+
Sbjct: 230 FPVPICRAEDACGGTMRGSSGIISSPSFPN-------EYHNNADCTWTIVAEPGDTISLI 282
Query: 207 CT-----SKDDQVGIWSGPAPQCIIPNKCTPPNV---ENGI---LVSDNR-------SLF 248
T K D + I P + PP + +N + V+D+ + +
Sbjct: 283 FTDFQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 342
Query: 249 SLNEVVEFRCQPGFGM---KGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDK 305
+ + ++F+ + GF + K S+ K LN E + + S +C PD E +R
Sbjct: 343 QVKKAIDFKSR-GFKLFPGKDNSN-KFSILN--EGGIKTASNLC---PDPGEPENGKRIG 395
Query: 306 DNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGD----WSPAAPRCEVKSCDDFLGQLPNGH 361
+FS G V +SC+ Y L+G+ + C + WS P C+VK+C L Q P+G
Sbjct: 396 SDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNL-QGPSGT 454
Query: 362 VLFP 365
P
Sbjct: 455 FTSP 458
Score = 58.2 bits (139), Expect = 2e-08
Identities = 107/470 (22%), Positives = 157/470 (33%), Gaps = 101/470 (21%)
Query: 61 LNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIK 120
L ++ SGR F+I + C +P P+N + Q S I
Sbjct: 705 LEFQADHSMSGRGFNI----------TYNTFGHNECPDPGIPINARRFG-DNFQLGSSIS 753
Query: 121 YSCPKGY-RLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHY 179
C +G+ + G+ + TCI+ V+W P C G P G F++ S
Sbjct: 754 VICEEGFIKTQGTETITCILMDGKVMWSGLIPKC-----GAP---CGGHFSAPSGVILSP 805
Query: 180 GSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPP-NVENG 238
G Y +L V E SI T + Q + PN +P NG
Sbjct: 806 GWPGYYKDSLNCEW--VIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNG 863
Query: 239 -----ILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPP 293
L S + ++ L R GF + H + +N + C P
Sbjct: 864 TQVPQFLFSSSNFIYLLFTTDNSRSNNGFKI----HYESVTVNTYS---------CLDPG 910
Query: 294 DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDF 353
+H R D FS G V +SC+ GY L L C WS P C+ D
Sbjct: 911 IPVHGRRYGHD---FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDV 967
Query: 354 LGQLPNGHVL-------FPLNLQLGAKVDFVCDEGFQ----------------------- 383
G P+G +L +P +L VD +G Q
Sbjct: 968 RG--PSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSF 1025
Query: 384 ------LKGSSASYCVLAGMESL-----------------WNSSVPVCERKSCETPPVPV 420
L GS + AG+ +N + + CE P +P
Sbjct: 1026 TQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQ 1085
Query: 421 NGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPIC 470
G + + +G + +SC++G+RL G S C L G WS P C
Sbjct: 1086 YGS-RIGFNFGIGDTLTFSCSSGYRLEGTSEIIC-LGGGRRVWSAPLPRC 1133
Score = 57.0 bits (136), Expect = 5e-08
Identities = 102/442 (23%), Positives = 157/442 (35%), Gaps = 59/442 (13%)
Query: 117 SQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREY 176
S I Y C GY L GSS C+ +G WD P C G ++G S
Sbjct: 1271 STIIYGCNPGYTLHGSSLLKCM-TGERRAWDYPLPSCIAECGGRFKGESSGRILSP---- 1325
Query: 177 FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKD-----DQVGIWSGPAPQCIIPNKCT 231
G Y NL + S+ + D D + +W GP ++ + +
Sbjct: 1326 ---GYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDMLLKEIS 1382
Query: 232 PPNVENGILVSDNRSLFSLNEVVEFRC-QPGFGMKGPSHVKCQALNKWEPELPSCSRVCQ 290
+ GI + N + ++ +F + GF ++ S V + C+
Sbjct: 1383 GSLIPEGIHSTLN--IVTIQFDTDFYISKSGFAIQFSSSV---------------ATACR 1425
Query: 291 PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGD---WSPAAPRCEV 347
P ++ R + D PG V + C+PGY+L+G + C + W P+ P C
Sbjct: 1426 DPGVPMNGTR---NGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA 1482
Query: 348 KSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPV 407
+ G +G +L P N CD + +A Y + S S P
Sbjct: 1483 PCGGNLTGS--SGFILSP-NFPHPYPHSRDCDWTITV---NADYVISLAFISF--SIEPN 1534
Query: 408 CERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKP 467
+ P + ++ D + RI S T H L S +G H K
Sbjct: 1535 YDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMH-LAFRSDGSVSYTG--FHLEYKA 1591
Query: 468 PICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSE 527
+ + C +P I+NG G D G V+Y CD + L G ST+
Sbjct: 1592 KLRES--CFDPGNIMNGTRLGM---DYKLGSTVTYYCD------AGYVLQGYSTLTCIMG 1640
Query: 528 PHGNGVWSSPAPRCELPVGAGS 549
G W+ P C P G+ S
Sbjct: 1641 DDGRPGWNRALPSCHAPCGSRS 1662
Score = 53.1 bits (126), Expect = 7e-07
Identities = 106/477 (22%), Positives = 159/477 (33%), Gaps = 60/477 (12%)
Query: 80 KNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATC-I 138
K S+ K C +P +P NG + D S +++SC + Y L G+ S TC
Sbjct: 366 KFSILNEGGIKTASNLCPDPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQR 424
Query: 139 ISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFE 198
I+ W + PVC CG +G FTS + + + + KV +
Sbjct: 425 IAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQ 484
Query: 199 LVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRC 258
+ E D + I G + + T V G V D S + +
Sbjct: 485 INFE-EFDLEIGYDTLTIGDGGE----VGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQT 539
Query: 259 QPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSC 318
G G +N E E SC P + R+ D FS + + C
Sbjct: 540 DESVGSVG------FKVNYKEIEKESCGDPGTPLYGI-------REGDGFSNRDVLRFEC 586
Query: 319 EPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFP-----LNLQLGAK 373
+ G++L G + C WS P C +F P G VL P L
Sbjct: 587 QFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTA--PMGTVLSPDYPEGYGNNLNCI 644
Query: 374 VDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG 433
+ D G ++ S + + S K ++P P+ G T V
Sbjct: 645 WTIISDPGSRIHLSFNDFDL--------ESQFDFLAVKDGDSPESPILG---TFTGAEVP 693
Query: 434 SRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIF----CPNPPAILNGRHTGT 489
S + + H L A+ +SG + I F CP+P +N R G
Sbjct: 694 SHLT---SNSHILRLEFQADHSMSGRGFN------ITYNTFGHNECPDPGIPINARRFG- 743
Query: 490 PLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVG 546
+ G +S C+ G TI G +WS P+C P G
Sbjct: 744 --DNFQLGSSISVICEEG-----FIKTQGTETI-TCILMDGKVMWSGLIPKCGAPCG 792
Score = 52.8 bits (125), Expect = 9e-07
Identities = 28/64 (43%), Positives = 35/64 (54%), Gaps = 2/64 (3%)
Query: 409 ERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECIL-SGNTAHWSMKP 467
+ SC P VP G+++ T VG +I YSC TG+ L GH CI S NTA W
Sbjct: 174 QSSSCGNPGVPPKGVLYG-TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPV 232
Query: 468 PICQ 471
PIC+
Sbjct: 233 PICR 236
Score = 46.6 bits (109), Expect = 6e-05
Identities = 95/434 (21%), Positives = 144/434 (33%), Gaps = 90/434 (20%)
Query: 95 SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCD 154
SC +P PV+G + D S + +SC GYRL C W + P CD
Sbjct: 905 SCLDPGIPVHGRRYG-HDFSIGSTVSFSCDSGYRLSHEEPLLC---EKNHWWSHPLPTCD 960
Query: 155 RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKV------FELVGEPSIYCT 208
+ CG +G S F+ S+ + GK V F L
Sbjct: 961 AL-CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLI 1019
Query: 209 SKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEV-VEFRCQPGFGMKGP 267
+++ S P + PP + G+ + L +++ + + GF +
Sbjct: 1020 TENG-----SFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYE---GFNITFS 1071
Query: 268 SHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGS 327
+ EP C+ P + R NF G + +SC GY L G+
Sbjct: 1072 EY-------NLEP--------CEDPGIPQYGSRIGF---NFGIGDTLTFSCSSGYRLEGT 1113
Query: 328 TYLHCTPQGD--WSPAAPRCEVK-------------SCDDFLGQLPNGHVLFPLNLQLGA 372
+ + C G WS PRC + S + L N ++ + +Q G
Sbjct: 1114 SEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGK 1173
Query: 373 KVD-----FVCDEGFQLK----------------GSSASYCVLAGMES-LW---NSSVPV 407
++ F +G LK G+S L+ + LW NS
Sbjct: 1174 GINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEG 1233
Query: 408 C-----------ERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECIL 456
E CE P +P G GS I Y C G+ L G S +C +
Sbjct: 1234 TDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKC-M 1292
Query: 457 SGNTAHWSMKPPIC 470
+G W P C
Sbjct: 1293 TGERRAWDYPLPSC 1306
Score = 40.8 bits (94), Expect = 0.003
Identities = 104/467 (22%), Positives = 167/467 (35%), Gaps = 76/467 (16%)
Query: 96 CRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVI-WDNKTPVCD 154
C + P+P G + + S + + C GY L GS + C N++ W++ P C
Sbjct: 1774 CSSVPEPRFGR-RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCI 1832
Query: 155 RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGK-KVFELVG---EPSIYCTSK 210
+ CG G T G Y NL K V E G + + T
Sbjct: 1833 -VPCG-------GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH 1884
Query: 211 D-DQVGIWSGP---APQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKG 266
+ D + + G AP+ + T P++ N S N + F+ G
Sbjct: 1885 NWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNST---------SNNLYLNFQSDISVSAAG 1935
Query: 267 PSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG 326
H++ A+ L SC P + + D + G V + C+ GY L+G
Sbjct: 1936 -FHLEYTAIG-----LDSCPEPQTPSSGI-------KIGDRYMVGDVVSFQCDQGYSLQG 1982
Query: 327 STYLHCTPQG--DWSPAAPRCEVK---SCDDFLGQL--PNGHVLFPLNLQLGAKVDFVCD 379
+++ C P W+ P C + + DF G + P +P +L ++
Sbjct: 1983 HSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIG 2042
Query: 380 EGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYS 439
G L+ + S + + + S ET V + ++ + S + +S
Sbjct: 2043 FGVHLQFVNFSTETIHDYLEVRSGS--------SETSTV-----IGRLSGPQIPSSL-FS 2088
Query: 440 CTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKE 499
T L HS S N + + Q CP+P NG G D G+
Sbjct: 2089 TTHETSLYFHSD----YSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGN---DFTVGQT 2141
Query: 500 VSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVG 546
+S+ C P + LIG S + N W+ P PRCE G
Sbjct: 2142 ISFECFPG------YTLIGNSALTCLHGVSRN--WNHPLPRCEALCG 2180
Score = 40.4 bits (93), Expect = 0.004
Identities = 63/274 (22%), Positives = 101/274 (36%), Gaps = 30/274 (10%)
Query: 96 CRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDR 155
C +P P G + + + + +SC GYRL G+S C+ G V W P C
Sbjct: 1078 CEDPGIPQYG-SRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRV-WSAPLPRCVA 1135
Query: 156 IICGLPPTIANGDFTSISREY-FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQV 214
CG T N + +S Y +Y + + C + + + + ++ D +
Sbjct: 1136 E-CGASAT--NNEGILLSPNYPLNYEN--NHECIYSIQVQAGKGINISARTFHLAQGDVL 1190
Query: 215 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLF-SLNEVVEFRCQPGFGMKGPSHVKCQ 273
I+ G + T ++ L S + L+ N E GF + S
Sbjct: 1191 KIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTE-GTDEGFQLVYTSF---- 1245
Query: 274 ALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCT 333
EL C P + D+ +F+ G + Y C PGY L GS+ L C
Sbjct: 1246 -------ELSHCE-----DPGIPQFGYKISDQGHFA-GSTIIYGCNPGYTLHGSSLLKCM 1292
Query: 334 --PQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFP 365
+ W P C + F G+ +G +L P
Sbjct: 1293 TGERRAWDYPLPSCIAECGGRFKGE-SSGRILSP 1325
Score = 37.7 bits (86), Expect = 0.029
Identities = 67/302 (22%), Positives = 102/302 (33%), Gaps = 53/302 (17%)
Query: 228 NKCTPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGF-GMKGPSHVKCQALN---KWEPEL 282
N+C P + N DN F L + C+ GF +G + C ++ W +
Sbjct: 728 NECPDPGIPINARRFGDN---FQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLI 784
Query: 283 PSCSRVC----QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDW 338
P C C P V+ SPG +Y L + P
Sbjct: 785 PKCGAPCGGHFSAPSGVI-----------LSPGWPGYYKDS----LNCEWVIEAEPGHSI 829
Query: 339 SPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 398
R + + D L ++L PL LG+ + F S+ Y +
Sbjct: 830 KITFERFQTELNYDVLEVHDGPNLLSPL---LGSYNGTQVPQ-FLFSSSNFIYLLFTTDN 885
Query: 399 SLWNSSVPV------CERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSA 452
S N+ + SC P +PV+G + D +GS +++SC +G+RL S
Sbjct: 886 SRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYG-HDFSIGSTVSFSCDSGYRL---SHE 941
Query: 453 ECILSGNTAHWSMKPPICQ------------QIFCPNPPAILNGRHTGTPLGDIPYGKEV 500
E +L WS P C I P P T D+ +GK V
Sbjct: 942 EPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGV 1001
Query: 501 SY 502
+
Sbjct: 1002 QF 1003
Score = 37.0 bits (84), Expect = 0.049
Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 1/59 (1%)
Query: 95 SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVC 153
+CR+P P+NG + + + + C GY L G TCI N W PVC
Sbjct: 1423 ACRDPGVPMNGTRNG-DGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1480
Score = 35.0 bits (79), Expect = 0.18
Identities = 30/122 (24%), Positives = 47/122 (38%), Gaps = 20/122 (16%)
Query: 373 KVDFVCDEGFQLKGSSASYCVLAGME------------------SLWNSSVPVCERKSCE 414
++ FV D + +G SA Y V ++ S+ N C
Sbjct: 324 RLHFVTDSNHRYRGFSAPYQVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCP 383
Query: 415 TPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAEC-ILSGNTAHWSMKPPICQQI 473
P P NG + +D +GS + +SC + L G S C ++ A WS P+C+
Sbjct: 384 DPGEPENGK-RIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVK 442
Query: 474 FC 475
C
Sbjct: 443 TC 444
Score = 33.9 bits (76), Expect = 0.41
Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 4/80 (5%)
Query: 346 EVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSV 405
+++SC D NG V+ + +G + F C G+ L G+SA C L G+ WN +
Sbjct: 2116 QLQSCPD-PRPFRNGFVIGN-DFTVGQTISFECFPGYTLIGNSALTC-LHGVSRNWNHPL 2172
Query: 406 PVCERKSCETPPVPVNGMVH 425
P CE C +NG ++
Sbjct: 2173 PRCE-ALCGGNITAMNGTIY 2191
Score = 31.2 bits (69), Expect = 2.7
Identities = 15/36 (41%), Positives = 21/36 (58%), Gaps = 2/36 (5%)
Query: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYS 70
C P +P A LT+D EF IG + Y+C PG++
Sbjct: 2291 CQPPPPVPNAEI--LTEDDEFEIGDIIRYQCLPGFT 2324
Score = 29.6 bits (65), Expect = 7.8
Identities = 14/53 (26%), Positives = 25/53 (47%), Gaps = 1/53 (1%)
Query: 357 LPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL-WNSSVPVC 408
+P VL+ +G K+ + C G+ L G C+ + + W+ VP+C
Sbjct: 183 VPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPIC 235
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 197 bits (502), Expect = 2e-50
Identities = 140/480 (29%), Positives = 206/480 (42%), Gaps = 46/480 (9%)
Query: 29 SSFSDQCNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSI-ICLKNSVWTSA 87
S S +C+ LP A E +G+ + Y C+PG+ + +CL+N W+ A
Sbjct: 2711 SCISIECD----LPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGA 2766
Query: 88 KDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWD 147
+C+ SC+ P +NG + + S + Y C GY L G+ TC N WD
Sbjct: 2767 SPRCEAISCKKPNPVMNGSIKG-SNYTYLSTLYYECDPGYVLNGTERRTCQDDKN---WD 2822
Query: 148 NKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYC 207
P+C + C PP ANG + + + + + Y CN G F L G S C
Sbjct: 2823 EDEPICIPVDCSSPPVSANGQ---VRGDEYTFQKEIEYTCNEG------FLLEGARSRVC 2873
Query: 208 TSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGP 267
+ G WSG P C+ TPP + NG+ + + + V F C G+ + G
Sbjct: 2874 LAN----GSWSGATPDCVPVRCATPPQLANGVTEGLD---YGFMKEVTFHCHEGYILHGA 2926
Query: 268 SHVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG 326
+ CQ+ W+ E+P C V C PP D+ H + +F G + Y C PGY L G
Sbjct: 2927 PKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFP---NGFSFIHGGHIQYQCFPGYKLHG 2983
Query: 327 STYLHCTPQGDWSPAAPRCEVKSCDDFLGQ--LPNGHVLFPLNLQLGAKVDFVCDEGFQL 384
++ C G WS ++P C C + + NG + G C +GF+L
Sbjct: 2984 NSSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNG-----TDFDCGKAARIQCFKGFKL 3038
Query: 385 KGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGH 444
G S C G W+S P CE SC + P+ N + T + I YSC +G+
Sbjct: 3039 LGLSEITCEADGQ---WSSGFPHCEHTSCGSLPMIPNAFISE-TSSWKENVITYSCRSGY 3094
Query: 445 RLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTC 504
+ G S C G WS P+C+ + C +PP++ N TG Y EV C
Sbjct: 3095 VIQGSSDLICTEKG---VWSQPYPVCEPLSCGSPPSVANAVATGEA---HTYESEVKLRC 3148
Score = 196 bits (498), Expect = 5e-50
Identities = 137/480 (28%), Positives = 210/480 (43%), Gaps = 46/480 (9%)
Query: 51 DDFEFPIGTYLNYECRPGYS-GRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHV 109
++ F G+ + Y C GY+ CL NS W+ + C+ C + P+ +N ++
Sbjct: 1859 EELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKC-SSPENINNGKYI 1917
Query: 110 IKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDF 169
+ + + S YSC GY L G S C SG IWD P C + CG PP I +
Sbjct: 1918 LSGLTYLSTASYSCDTGYSLQGPSIIECTASG---IWDRAPPACHLVFCGEPPAIKDAVI 1974
Query: 170 TSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNK 229
T F + + VTY C K+ + L G +I C + G WS QC+ +
Sbjct: 1975 TG---NNFTFRNTVTYTC------KEGYTLAGLDTIECLAD----GKWSRSDQQCLAVSC 2021
Query: 230 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEP----ELPSC 285
PP V++ + +R LF ++ + C G+ + S + C A KW P ++P C
Sbjct: 2022 DEPPIVDHASPETAHR-LF--GDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRC 2078
Query: 286 -SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDW--SPAA 342
+ C+ PP V ++ K F+ G V + C G+ L S + C G W SP +
Sbjct: 2079 IAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMS 2138
Query: 343 PRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWN 402
+C C + + NG+ N GA V + C++GF +KG S C G W+
Sbjct: 2139 IQCIPVRCGE-PPSIMNGYA-SGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQ---WS 2193
Query: 403 SSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAH 462
S +P C SC PP NG + T S + Y C G++ +G C + H
Sbjct: 2194 SPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQAN---RH 2250
Query: 463 W-SMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGEST 521
W S P +C + C PP I NG G + G +V + C+ + L+G+S+
Sbjct: 2251 WHSESPLMCVPLDCGKPPPIQNGFMKGE---NFEVGSKVQFFCNE------GYELVGDSS 2301
Score = 183 bits (464), Expect = 4e-46
Identities = 150/567 (26%), Positives = 225/567 (39%), Gaps = 92/567 (16%)
Query: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSI-ICLKNSVWTSAKDKCKR 93
C P + F P + G+ + Y C G+ R S +C + W+S +C
Sbjct: 2381 CTPPPLISFGVPIPSS---ALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVP 2437
Query: 94 KSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVC 153
C P + NG+ V + + + S Y+C G+ L+G+++ C +G+ W P C
Sbjct: 2438 VECPQPEEIPNGIIDV-QGLAYLSTALYTCKPGFELVGNTTTLCGENGH---WLGGKPTC 2493
Query: 154 DRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQ 213
I C P I NG F+ HYG VTY CN G F L G ++ C +
Sbjct: 2494 KAIECLKPKEILNGKFSYTD---LHYGQTVTYSCNRG------FRLEGPSALTCL----E 2540
Query: 214 VGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQ 273
G W AP C + +P +ENG + + +S ++ + C PGF + G + C+
Sbjct: 2541 TGDWDVDAPSCNAIHCDSPQPIENGFVEGAD---YSYGAIIIYSCFPGFQVAGHAMQTCE 2597
Query: 274 ALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKD-------------------------- 306
+ W +P+C + C PP + + T+ D
Sbjct: 2598 E-SGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGA 2656
Query: 307 -----------------NFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKS 349
NF G V Y+C PGY+L G+ L C G W+ +AP C
Sbjct: 2657 VAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIE 2716
Query: 350 CDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE 409
CD L P L +G+ V + C G L GS C+ W+ + P CE
Sbjct: 2717 CD--LPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCL---ENRKWSGASPRCE 2771
Query: 410 RKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPI 469
SC+ P +NG + ++ S + Y C G+ L G C + +W PI
Sbjct: 2772 AISCKKPNPVMNGSIKGSNYTYL-STLYYECDPGYVLNGTERRTC---QDDKNWDEDEPI 2827
Query: 470 CQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPH 529
C + C +PP NG+ G + + KE+ YTC+ F L G R+
Sbjct: 2828 CIPVDCSSPPVSANGQVRG---DEYTFQKEIEYTCNE------GFLLEG----ARSRVCL 2874
Query: 530 GNGVWSSPAPRCELPVGAGSHDALIVG 556
NG WS P C +PV + L G
Sbjct: 2875 ANGSWSGATPDC-VPVRCATPPQLANG 2900
Score = 182 bits (462), Expect = 7e-46
Identities = 128/434 (29%), Positives = 195/434 (44%), Gaps = 66/434 (15%)
Query: 111 KDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFT 170
+D++ S++ C G++L+G+ C+ G W P C+RI CG+PP + NG
Sbjct: 1646 EDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQ---WTQPLPHCERISCGVPPPLENGFH- 1701
Query: 171 SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKC 230
S + F+ GS VTY CN G + L+G+ ++CT G W+G +P C+ ++C
Sbjct: 1702 --SADDFYAGSTVTYQCNNG------YYLLGDSRMFCTDN----GSWNGVSPSCLDVDEC 1749
Query: 231 TPPNVENGILVSDNRSLFSLNEVVEFRCQP---GFGMKGPSHVKCQALNKWEPELPSCSR 287
G S++ S +++ C P G G +KC+A P P
Sbjct: 1750 AV-----GSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKA-----PGNP---- 1795
Query: 288 VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEV 347
E + ++ G EV +SC+ GY L G T + C G+W+ P C+
Sbjct: 1796 -----------ENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKA 1844
Query: 348 KSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPV 407
SC +P + L G+KV + C++G+ L G S C+ S W+ S PV
Sbjct: 1845 VSCGK--PAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCL---ANSSWSHSPPV 1899
Query: 408 CERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKP 467
CE C +P +N ++++ + S +YSC TG+ L G S EC SG W P
Sbjct: 1900 CEPVKCSSPE-NINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASG---IWDRAP 1955
Query: 468 PICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSE 527
P C +FC PPAI + TG + + V+YTC + L G TI E
Sbjct: 1956 PACHLVFCGEPPAIKDAVITG---NNFTFRNTVTYTCKE------GYTLAGLDTI----E 2002
Query: 528 PHGNGVWSSPAPRC 541
+G WS +C
Sbjct: 2003 CLADGKWSRSDQQC 2016
Score = 181 bits (460), Expect = 1e-45
Identities = 153/521 (29%), Positives = 214/521 (41%), Gaps = 60/521 (11%)
Query: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFS-IICLKNSVWTSAKD---- 89
C+ P + A P F G Y C GYS S ++C W +
Sbjct: 2021 CDEPPIVDHASPETAHRLF----GDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMP 2076
Query: 90 KCKRKSCRNPPDPVNGMAHVIKDIQFR--SQIKYSCPKGYRLIGSSSATCIISGNTVIWD 147
+C C PP + + +F S + + C +G+ L S+ C+ G W
Sbjct: 2077 RCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQ---W- 2132
Query: 148 NKTPV---CDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPS 204
N +P+ C + CG PP+I NG S + +G++V Y CN G F + GE
Sbjct: 2133 NPSPMSIQCIPVRCGEPPSIMNG---YASGSNYSFGAMVAYSCNKG------FYIKGEKK 2183
Query: 205 IYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGM 264
C + G WS P P C + PP VENG L +F V ++C PG+
Sbjct: 2184 STC----EATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESE--VRYQCNPGYKS 2237
Query: 265 KGPSHVKCQALNKWEPELP-SCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY 322
G CQA W E P C + C PP + + +NF G +V + C GY
Sbjct: 2238 VGSPVFVCQANRHWHSESPLMCVPLDCGKPPPI---QNGFMKGENFEVGSKVQFFCNEGY 2294
Query: 323 DLRGSTYLHCTPQGDWSPAA-PRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEG 381
+L G + C G W+ + P+C C + L N VL L ++G V F C EG
Sbjct: 2295 ELVGDSSWTCQKSGKWNKKSNPKCMPAKCPE-PPLLENQLVLKELTTEVGV-VTFSCKEG 2352
Query: 382 FQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCT 441
L+G S C+ + WN S PVC+ C PP+ G+ + +H GS + YSC
Sbjct: 2353 HVLQGPSVLKCLPSQQ---WNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKYSCV 2409
Query: 442 TGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVS 501
G L G+S+ C G WS P C + CP P I NG + + Y
Sbjct: 2410 GGFFLRGNSTTLCQPDGT---WSSPLPECVPVECPQPEEIPNGI---IDVQGLAYLSTAL 2463
Query: 502 YTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542
YTC P F L+G +T NG W P C+
Sbjct: 2464 YTCKP------GFELVGNTTTLCGE----NGHWLGGKPTCK 2494
Score = 177 bits (448), Expect = 3e-44
Identities = 145/511 (28%), Positives = 209/511 (40%), Gaps = 67/511 (13%)
Query: 50 TDDFEFPIGTYLNYECRPGYS--GRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMA 107
T F GT ++Y C PGY G P +IC ++ W + C C P P NG
Sbjct: 2670 THSSNFLYGTMVSYTCNPGYELLGNPV-LICQEDGTWNGSAPSCISIECDLPTAPENGFL 2728
Query: 108 HVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANG 167
+ S ++YSC G+ L GS C+ + W +P C+ I C P + NG
Sbjct: 2729 R-FTETSMGSAVQYSCKPGHILAGSDLRLCLENRK---WSGASPRCEAISCKKPNPVMNG 2784
Query: 168 DFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIP 227
SI + Y S + Y C+ G + L G C +DD+ W P CI
Sbjct: 2785 ---SIKGSNYTYLSTLYYECDPG------YVLNGTERRTC--QDDKN--WDEDEPICIPV 2831
Query: 228 NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSR 287
+ +PP NG + D ++ + +E+ C GF ++G C A W P C
Sbjct: 2832 DCSSPPVSANGQVRGDE---YTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVP 2888
Query: 288 V-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCE 346
V C PP + + D + +EV + C GY L G+ L C G+W P C+
Sbjct: 2889 VRCATPPQLANGVTEGLD---YGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCK 2945
Query: 347 VKSC---DDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS 403
+C +D PNG G + + C G++L G+S+ C+ G W+
Sbjct: 2946 PVNCGPPEDLAHGFPNGFSFIH-----GGHIQYQCFPGYKLHGNSSRRCLSNGS---WSG 2997
Query: 404 SVPVCERKSCETPPVP---VNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNT 460
S P C C TP + VNG TD G C G +L+G S C G
Sbjct: 2998 SSPSCLPCRCSTPVIEYGTVNG-----TDFDCGKAARIQCFKGFKLLGLSEITCEADGQ- 3051
Query: 461 AHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKE--VSYTCDPHPDRGMTFNLIG 518
WS P C+ C + P I N + + KE ++Y+C + + G
Sbjct: 3052 --WSSGFPHCEHTSCGSLPMIPNAF-----ISETSSWKENVITYSCRSG------YVIQG 3098
Query: 519 ESTIRRTSEPHGNGVWSSPAPRCELPVGAGS 549
S + T + GVWS P P CE P+ GS
Sbjct: 3099 SSDLICTEK----GVWSQPYPVCE-PLSCGS 3124
Score = 175 bits (444), Expect = 9e-44
Identities = 140/490 (28%), Positives = 210/490 (42%), Gaps = 67/490 (13%)
Query: 75 SIICLKNSVWTSAKDKCKRK-SCRNPPDPVNGMAHVIKDIQ-FRSQIKYSCPKGYRLIGS 132
S IC +T C C+ P +P NG H +I +++ +SC +GY+L+G
Sbjct: 1767 SYICSCVPPYTGDGKNCAEPIKCKAPGNPENG--HSSGEIYTVGAEVTFSCQEGYQLMGV 1824
Query: 133 SSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSR 192
+ TC+ SG W++ P C + CG P NG ++ F +GS VTY CN G
Sbjct: 1825 TKITCLESGE---WNHLIPYCKAVSCGKPAIPENGCIEELA---FTFGSKVTYRCNKG-- 1876
Query: 193 GKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPP-NVENGILVSDNRSLFSLN 251
+ L G+ C + WS P C P KC+ P N+ NG + + S
Sbjct: 1877 ----YTLAGDKESSCLANSS----WSHSPPVCE-PVKCSSPENINNGKYILSGLTYLS-- 1925
Query: 252 EVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSP 310
+ C G+ ++GPS ++C A W+ P+C V C PP + A T +NF+
Sbjct: 1926 -TASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITG---NNFTF 1981
Query: 311 GQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDD----FLGQLPNGHVLFPL 366
V Y+C+ GY L G + C G WS + +C SCD+ H LF
Sbjct: 1982 RNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLF-- 2039
Query: 367 NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLW----NSSVPVCERKSCETPPVPVNG 422
G + C +G+ L +S C G W +P C CE PP
Sbjct: 2040 ----GDIAFYYCSDGYSLADNSQLLCNAQGK---WVPPEGQDMPRCIAHFCEKPPSVSYS 2092
Query: 423 MVHVIT--DIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPI--CQQIFCPNP 478
++ ++ GS +++ C G L + EC+ G W+ P C + C P
Sbjct: 2093 ILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGG---QWNPSPMSIQCIPVRCGEP 2149
Query: 479 PAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPA 538
P+I+NG +G+ + +G V+Y+C+ F + GE + S G WSSP
Sbjct: 2150 PSIMNGYASGS---NYSFGAMVAYSCN------KGFYIKGE----KKSTCEATGQWSSPI 2196
Query: 539 PRCELPVGAG 548
P C PV G
Sbjct: 2197 PTCH-PVSCG 2205
Score = 174 bits (440), Expect = 3e-43
Identities = 128/465 (27%), Positives = 197/465 (42%), Gaps = 34/465 (7%)
Query: 29 SSFSDQCNVPEWLPFARPTNLTDDFEFPIG-TYLN---YECRPGYSGRPFSII-CLKNSV 83
SS+S V E + + P N+ + G TYL+ Y C GYS + SII C + +
Sbjct: 1891 SSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGI 1950
Query: 84 WTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNT 143
W A C C PP + + FR+ + Y+C +GY L G + C+ G
Sbjct: 1951 WDRAPPACHLVFCGEPP-AIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGK- 2008
Query: 144 VIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEP 203
W C + C PP + D S + +G + Y+C+ G + L
Sbjct: 2009 --WSRSDQQCLAVSCDEPPIV---DHASPETAHRLFGDIAFYYCSDG------YSLADNS 2057
Query: 204 SIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFG 263
+ C ++ V P+CI PP+V IL S +++ F+ VV F+C GF
Sbjct: 2058 QLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFV 2117
Query: 264 MKGPSHVKCQALNKWEPELPSCSRV---CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEP 320
+ + ++C +W P S + C PP +++ N+S G V YSC
Sbjct: 2118 LNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNG---YASGSNYSFGAMVAYSCNK 2174
Query: 321 GYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDE 380
G+ ++G C G WS P C SC + ++ NG + ++V + C+
Sbjct: 2175 GFYIKGEKKSTCEATGQWSSPIPTCHPVSCGE-PPKVENGFLEHTTGRIFESEVRYQCNP 2233
Query: 381 GFQLKGSSASYCVLAGMESLWNSSVP-VCERKSCETPPVPVNGMVHVITDIHVGSRINYS 439
G++ GS C W+S P +C C PP NG + + VGS++ +
Sbjct: 2234 GYKSVGSPVFVC---QANRHWHSESPLMCVPLDCGKPPPIQNGFMKG-ENFEVGSKVQFF 2289
Query: 440 CTTGHRLIGHSSAECILSGNTAHWSMKP-PICQQIFCPNPPAILN 483
C G+ L+G SS C SG W+ K P C CP PP + N
Sbjct: 2290 CNEGYELVGDSSWTCQKSGK---WNKKSNPKCMPAKCPEPPLLEN 2331
Score = 168 bits (426), Expect = 1e-41
Identities = 155/556 (27%), Positives = 217/556 (39%), Gaps = 117/556 (21%)
Query: 54 EFPIGTYLNYECRPGYSGRPF-SIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKD 112
E+ + Y C G+ S +CL N W+ A C C PP NG+ + D
Sbjct: 2848 EYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGL-D 2906
Query: 113 IQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSI 172
F ++ + C +GY L G+ TC GN WD + P+C + CG P +A+G
Sbjct: 2907 YGFMKEVTFHCHEGYILHGAPKLTCQSDGN---WDAEIPLCKPVNCGPPEDLAHGFPNGF 2963
Query: 173 SREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTP 232
S F +G + Y C G ++L G S C S G WSG +P C+ P +C+
Sbjct: 2964 S---FIHGGHIQYQCFPG------YKLHGNSSRRCLSN----GSWSGSSPSCL-PCRCST 3009
Query: 233 PNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV-CQP 291
P +E G + N + F + +C GF + G S + C+A +W P C C
Sbjct: 3010 PVIEYGTV---NGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGS 3066
Query: 292 PPDVLHA--ERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC---- 345
P + +A T K+N + YSC GY ++GS+ L CT +G WS P C
Sbjct: 3067 LPMIPNAFISETSSWKENV-----ITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLS 3121
Query: 346 ---------------------EVK-----------------------------SCDDFLG 355
EVK SC
Sbjct: 3122 CGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKC 3181
Query: 356 QLPNG--HVL-----FPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS--SVP 406
LP H+L F +N Q+ C EG+ +G + S C L G W S
Sbjct: 3182 PLPENITHILVHGDDFSVNRQVSVS----CAEGYTFEGVNISVCQLDGT---WEPPFSDE 3234
Query: 407 VCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMK 466
C SC P P +G V V + S I Y C G+ L G+ C WS
Sbjct: 3235 SCSPVSCGKPESPEHGFV-VGSKYTFESTIIYQCEPGYELEGNRERVC---QENRQWSGG 3290
Query: 467 PPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTS 526
IC++ C P LNG+ + + G V Y+C +RG ++L G S T
Sbjct: 3291 VAICKETRCETPLEFLNGK---ADIENRTTGPNVVYSC----NRG--YSLEGPSEAHCTE 3341
Query: 527 EPHGNGVWSSPAPRCE 542
NG WS P P C+
Sbjct: 3342 ----NGTWSHPVPLCK 3353
Score = 165 bits (417), Expect = 1e-40
Identities = 130/452 (28%), Positives = 184/452 (40%), Gaps = 48/452 (10%)
Query: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSII-CLKNSVWTSAKDKCKR 93
C PE L P F F G ++ Y+C PGY S CL N W+ + C
Sbjct: 2949 CGPPEDLAHGFPNG----FSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLP 3004
Query: 94 KSCRNPP---DPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKT 150
C P VNG D + C KG++L+G S TC G W +
Sbjct: 3005 CRCSTPVIEYGTVNGT-----DFDCGKAARIQCFKGFKLLGLSEITCEADGQ---WSSGF 3056
Query: 151 PVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSK 210
P C+ CG P I N IS +V+TY C G + + G + CT K
Sbjct: 3057 PHCEHTSCGSLPMIPNA---FISETSSWKENVITYSCRSG------YVIQGSSDLICTEK 3107
Query: 211 DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHV 270
G+WS P P C + +PP+V N + + + S V+ RC G+ M +
Sbjct: 3108 ----GVWSQPYPVCEPLSCGSPPSVANAVATGEAHTYES---EVKLRCLEGYTMDTDTDT 3160
Query: 271 -KCQALNKWEPELPSCS-RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGST 328
CQ +W PE SCS + C P ++ H D+FS ++V SC GY G
Sbjct: 3161 FTCQKDGRWFPERISCSPKKCPLPENITHI---LVHGDDFSVNRQVSVSCAEGYTFEGVN 3217
Query: 329 YLHCTPQGDWSP--AAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKG 386
C G W P + C SC + P + + + + C+ G++L+G
Sbjct: 3218 ISVCQLDGTWEPPFSDESCSPVSCGK--PESPEHGFVVGSKYTFESTIIYQCEPGYELEG 3275
Query: 387 SSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRL 446
+ C W+ V +C+ CETP +NG I + G + YSC G+ L
Sbjct: 3276 NRERVCQ---ENRQWSGGVAICKETRCETPLEFLNGKAD-IENRTTGPNVVYSCNRGYSL 3331
Query: 447 IGHSSAECILSGNTAHWSMKPPICQQIFCPNP 478
G S A C +G WS P+C+ CP P
Sbjct: 3332 EGPSEAHCTENGT---WSHPVPLCKPNPCPVP 3360
Score = 145 bits (367), Expect = 7e-35
Identities = 111/427 (25%), Positives = 164/427 (38%), Gaps = 53/427 (12%)
Query: 58 GTYLNYECRPGYS--GRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQF 115
G+ +N C PG+ G P CL WT C+R SC PP NG H D
Sbjct: 1651 GSKVNLFCDPGFQLVGNPVQY-CLNQGQWTQPLPHCERISCGVPPPLENGF-HSADDFYA 1708
Query: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
S + Y C GY L+G S C +G+ W+ +P C
Sbjct: 1709 GSTVTYQCNNGYYLLGDSRMFCTDNGS---WNGVSPSC---------------------- 1743
Query: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKC-TPPN 234
+ C +GS + + Y S V ++G C P KC P N
Sbjct: 1744 ------LDVDECAVGSDCSEHASCLNVDGSYICS---CVPPYTGDGKNCAEPIKCKAPGN 1794
Query: 235 VENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPD 294
ENG + ++++ V F CQ G+ + G + + C +W +P C V P
Sbjct: 1795 PENG---HSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPA 1851
Query: 295 VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFL 354
+ E ++ F+ G +V Y C GY L G C WS + P CE C
Sbjct: 1852 I--PENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSS-P 1908
Query: 355 GQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCE 414
+ NG + L + + CD G+ L+G S C +G +W+ + P C C
Sbjct: 1909 ENINNGKYILS-GLTYLSTASYSCDTGYSLQGPSIIECTASG---IWDRAPPACHLVFCG 1964
Query: 415 TPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIF 474
PP + V + + + Y+C G+ L G + EC+ G WS C +
Sbjct: 1965 EPPA-IKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGK---WSRSDQQCLAVS 2020
Query: 475 CPNPPAI 481
C PP +
Sbjct: 2021 CDEPPIV 2027
Score = 145 bits (367), Expect = 7e-35
Identities = 120/427 (28%), Positives = 182/427 (42%), Gaps = 55/427 (12%)
Query: 61 LNYECRPGYSGRPFS-IICLKNSVWTSAKDKCKRKSCRNPPDPVN----GMAHVIKDIQF 115
+ Y CR GY + S +IC + VW+ C+ SC +PP N G AH +
Sbjct: 3086 ITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAHT-----Y 3140
Query: 116 RSQIKYSCPKGYRL-IGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIAN----GDFT 170
S++K C +GY + + + TC G W + C C LP I + GD
Sbjct: 3141 ESEVKLRCLEGYTMDTDTDTFTCQKDGR---WFPERISCSPKKCPLPENITHILVHGDDF 3197
Query: 171 SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGP-APQCIIPNK 229
S++R+ V+ C G FE V +I D G W P + + P
Sbjct: 3198 SVNRQ-------VSVSCAEGY----TFEGV---NISVCQLD---GTWEPPFSDESCSPVS 3240
Query: 230 C-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV 288
C P + E+G +V S ++ + ++C+PG+ ++G CQ +W + C
Sbjct: 3241 CGKPESPEHGFVVG---SKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKET 3297
Query: 289 -CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEV 347
C+ P + L+ + D +N + G V YSC GY L G + HCT G WS P C+
Sbjct: 3298 RCETPLEFLNGKA---DIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKP 3354
Query: 348 KSCD-DFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVP 406
C F+ +P +L + V C EGF L+G C + W +
Sbjct: 3355 NPCPVPFV--IPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITC---NPDETWTQTSA 3409
Query: 407 VCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMK 466
CE+ SC PP V + G I YSC +G+ L G + C+ +G W+
Sbjct: 3410 KCEKISC-GPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGT---WT-S 3464
Query: 467 PPICQQI 473
PPIC+ +
Sbjct: 3465 PPICRAV 3471
Score = 64.7 bits (156), Expect = 2e-10
Identities = 59/208 (28%), Positives = 87/208 (41%), Gaps = 28/208 (13%)
Query: 281 ELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSP 340
EL C + +PP + + T + N + G C PG+DL GS+ + C P G WS
Sbjct: 374 ELVHCPAL-KPPENGYFIQNTCNNHFNAACGVR----CHPGFDLVGSSIILCLPNGLWSG 428
Query: 341 AAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFV-CDEGFQLKGSSASYCVLAGMES 399
+ C V++C L Q +GH+ L V CDEG++L+GS C S
Sbjct: 429 SESYCRVRTC-PHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC---QGNS 484
Query: 400 LWNSSVPVCERKSCETPPVPVNGMVHVITDIH--------VGSRINYSCTTGHRLIG-HS 450
W+ P C + C T +P + VI H G+ SC G L G
Sbjct: 485 QWDGPEPRCVERHCSTFQMPKD----VIISPHNCGKQPAKFGTICYVSCRQGFILSGVKE 540
Query: 451 SAECILSGNTAHWS--MKPPICQQIFCP 476
C SG W+ ++ +C+ + P
Sbjct: 541 MLRCTTSGK---WNVGVQAAVCKDVEAP 565
Score = 52.8 bits (125), Expect = 9e-07
Identities = 29/91 (31%), Positives = 50/91 (54%), Gaps = 5/91 (5%)
Query: 65 CRPGYSGRPFSII-CLKNSVWTSAKDKCKRKSCRNPPDPVNG-MAHVIKDIQFRSQIKYS 122
C PG+ SII CL N +W+ ++ C+ ++C + P +G ++ +++ +++ +
Sbjct: 406 CHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVA 465
Query: 123 CPKGYRLIGSSSATCIISGNTVIWDNKTPVC 153
C +GYRL GS TC GN+ WD P C
Sbjct: 466 CDEGYRLEGSDKLTC--QGNSQ-WDGPEPRC 493
Score = 50.8 bits (120), Expect = 3e-06
Identities = 51/195 (26%), Positives = 76/195 (38%), Gaps = 24/195 (12%)
Query: 153 CDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDD 212
C+ + C NG F + H+ + C+ G F+LVG I C
Sbjct: 373 CELVHCPALKPPENGYFIQNTCNN-HFNAACGVRCHPG------FDLVGSSIILCLPN-- 423
Query: 213 QVGIWSGPAPQCII---PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSH 269
G+WSG C + P+ P + I S L+ +V C G+ ++G
Sbjct: 424 --GLWSGSESYCRVRTCPHLRQPKH--GHISCSTREMLYKTTCLVA--CDEGYRLEGSDK 477
Query: 270 VKCQALNKWEPELPSC-SRVC---QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLR 325
+ CQ ++W+ P C R C Q P DV+ + K G + SC G+ L
Sbjct: 478 LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPH-NCGKQPAKFGTICYVSCRQGFILS 536
Query: 326 G-STYLHCTPQGDWS 339
G L CT G W+
Sbjct: 537 GVKEMLRCTTSGKWN 551
Score = 44.7 bits (104), Expect = 2e-04
Identities = 54/227 (23%), Positives = 76/227 (33%), Gaps = 43/227 (18%)
Query: 318 CEPGYDLRGSTYLHCT--PQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVD 375
CE GY +G Y CT P G + P + SC + H P + + D
Sbjct: 307 CEKGYYGKGLQY-ECTACPSGTYKPEGSPGGISSC---IPCPDENHTSPPGST---SPED 359
Query: 376 FVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNG-MVHVITDIHVGS 434
VC EG++ G + CE C P NG + + H +
Sbjct: 360 CVCREGYRASGQT-------------------CELVHCPALKPPENGYFIQNTCNNHFNA 400
Query: 435 RINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDI 494
C G L+G S C+ +G WS C+ CP+ +G H ++
Sbjct: 401 ACGVRCHPGFDLVGSSIILCLPNGL---WSGSESYCRVRTCPHLRQPKHG-HISCSTREM 456
Query: 495 PYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
Y CD + L G + GN W P PRC
Sbjct: 457 LYKTTCLVACDEG------YRLEGSDKLTC----QGNSQWDGPEPRC 493
Score = 30.8 bits (68), Expect = 3.5
Identities = 21/73 (28%), Positives = 31/73 (42%), Gaps = 11/73 (15%)
Query: 471 QQIFCPNPPAILNG-RHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPH 529
+ IFC + P + H T D+ G +V+ CDP F L+G ++
Sbjct: 1624 KSIFCSDCPRLGGSVPHLRTASEDLKPGSKVNLFCDPG------FQLVGNPVQYCLNQ-- 1675
Query: 530 GNGVWSSPAPRCE 542
G W+ P P CE
Sbjct: 1676 --GQWTQPLPHCE 1686
>gi|27502413 CD46 antigen, complement regulatory protein isoform 7
precursor [Homo sapiens]
Length = 378
Score = 195 bits (496), Expect = 8e-50
Identities = 116/310 (37%), Positives = 155/310 (50%), Gaps = 16/310 (5%)
Query: 1 MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY 60
M PP R E PFPS RFPGLLLAA+VLLL SFSD C P + + IG
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPY-YEIGER 59
Query: 61 LNYECRPGYSGRP---FSIICLKNSVWTSAKDK-CKRKSCRNPPDPVNGMAHVIKDI-QF 115
++Y+C+ GY P IC +N W D C R++C DP+NG A +F
Sbjct: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEF 119
Query: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
Q+ + C +GY LIG C + G+ IW K P+C++++C PP I NG T E
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVE 179
Query: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235
F Y VTY C+ + G F L+GE +IYC +WS AP+C + KC P V
Sbjct: 180 VFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVV 233
Query: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQP---- 291
ENG +S F V F C GF + G + C + + W+P +P C +V P
Sbjct: 234 ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTK 293
Query: 292 PPDVLHAERT 301
PP + H+ T
Sbjct: 294 PPALSHSVST 303
Score = 105 bits (262), Expect = 1e-22
Identities = 61/176 (34%), Positives = 91/176 (51%), Gaps = 6/176 (3%)
Query: 369 QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGM-VHVI 427
++G +VD+ C +G+ A++ + + S C R++C P+NG V
Sbjct: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
Query: 428 TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHT 487
G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG+HT
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT 174
Query: 488 GTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
+ + Y V+Y+CDP P F+LIGESTI N VWS AP C++
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD----NSVWSRAAPECKV 225
Score = 99.4 bits (246), Expect = 8e-21
Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 28/272 (10%)
Query: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--STYLHCTPQGDWS 339
L S S C+ PP E + K + G+ V Y C+ GY +T+ C W
Sbjct: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
Query: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397
P + + ++ NG + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
Query: 398 ESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG---SRINYSCTTG-----HRLIGH 449
++W+ P+CE+ C PP NG H +++ V + YSC LIG
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGE 205
Query: 450 SSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPD 509
S+ C G+ + WS P C+ + C P + NG+ Y V + CD
Sbjct: 206 STIYC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD---- 257
Query: 510 RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
F L G TI S N W P P+C
Sbjct: 258 --KGFYLDGSDTIVCDS----NSTWDPPVPKC 283
Score = 82.4 bits (202), Expect = 1e-15
Identities = 61/233 (26%), Positives = 87/233 (37%), Gaps = 13/233 (5%)
Query: 118 QIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYF 177
++ Y C KGY I + I N C R C NG + Y
Sbjct: 59 RVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTY- 117
Query: 178 HYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVEN 237
+G + + CN G + L+GE +YC K V IWSG P C PP ++N
Sbjct: 118 EFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPPKIKN 170
Query: 238 GILVSDNRSLFSLNEVVEFRCQPG-----FGMKGPSHVKCQALNKWEPELPSCSRVCQPP 292
G +F + V + C P F + G S + C + W P C V
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC 345
P V + ++ F V + C+ G+ L GS + C W P P+C
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 80.1 bits (196), Expect = 5e-15
Identities = 70/265 (26%), Positives = 103/265 (38%), Gaps = 30/265 (11%)
Query: 158 CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217
C PPT + + Y+ G V Y C G F + P + + D+ W
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
Query: 218 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
+ C P + NG V N + + + F C G+ + G + C+
Sbjct: 87 LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
Query: 275 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 325
W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVL--FPLNLQLGAKVDFVCDEGFQ 383
G + ++C WS AAP C+V C + NG + F A V F CD+GF
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 384 LKGSSASYCVLAGMESLWNSSVPVC 408
L GS C S W+ VP C
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKC 283
>gi|27502402 CD46 antigen, complement regulatory protein isoform 1
precursor [Homo sapiens]
Length = 392
Score = 195 bits (496), Expect = 8e-50
Identities = 116/310 (37%), Positives = 155/310 (50%), Gaps = 16/310 (5%)
Query: 1 MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY 60
M PP R E PFPS RFPGLLLAA+VLLL SFSD C P + + IG
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPY-YEIGER 59
Query: 61 LNYECRPGYSGRP---FSIICLKNSVWTSAKDK-CKRKSCRNPPDPVNGMAHVIKDI-QF 115
++Y+C+ GY P IC +N W D C R++C DP+NG A +F
Sbjct: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEF 119
Query: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
Q+ + C +GY LIG C + G+ IW K P+C++++C PP I NG T E
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVE 179
Query: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235
F Y VTY C+ + G F L+GE +IYC +WS AP+C + KC P V
Sbjct: 180 VFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVV 233
Query: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQP---- 291
ENG +S F V F C GF + G + C + + W+P +P C +V P
Sbjct: 234 ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTK 293
Query: 292 PPDVLHAERT 301
PP + H+ T
Sbjct: 294 PPALSHSVST 303
Score = 105 bits (262), Expect = 1e-22
Identities = 61/176 (34%), Positives = 91/176 (51%), Gaps = 6/176 (3%)
Query: 369 QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGM-VHVI 427
++G +VD+ C +G+ A++ + + S C R++C P+NG V
Sbjct: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
Query: 428 TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHT 487
G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG+HT
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT 174
Query: 488 GTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
+ + Y V+Y+CDP P F+LIGESTI N VWS AP C++
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD----NSVWSRAAPECKV 225
Score = 99.4 bits (246), Expect = 8e-21
Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 28/272 (10%)
Query: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--STYLHCTPQGDWS 339
L S S C+ PP E + K + G+ V Y C+ GY +T+ C W
Sbjct: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
Query: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397
P + + ++ NG + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
Query: 398 ESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG---SRINYSCTTG-----HRLIGH 449
++W+ P+CE+ C PP NG H +++ V + YSC LIG
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGE 205
Query: 450 SSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPD 509
S+ C G+ + WS P C+ + C P + NG+ Y V + CD
Sbjct: 206 STIYC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD---- 257
Query: 510 RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
F L G TI S N W P P+C
Sbjct: 258 --KGFYLDGSDTIVCDS----NSTWDPPVPKC 283
Score = 82.4 bits (202), Expect = 1e-15
Identities = 61/233 (26%), Positives = 87/233 (37%), Gaps = 13/233 (5%)
Query: 118 QIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYF 177
++ Y C KGY I + I N C R C NG + Y
Sbjct: 59 RVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTY- 117
Query: 178 HYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVEN 237
+G + + CN G + L+GE +YC K V IWSG P C PP ++N
Sbjct: 118 EFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPPKIKN 170
Query: 238 GILVSDNRSLFSLNEVVEFRCQPG-----FGMKGPSHVKCQALNKWEPELPSCSRVCQPP 292
G +F + V + C P F + G S + C + W P C V
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC 345
P V + ++ F V + C+ G+ L GS + C W P P+C
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 80.1 bits (196), Expect = 5e-15
Identities = 70/265 (26%), Positives = 103/265 (38%), Gaps = 30/265 (11%)
Query: 158 CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217
C PPT + + Y+ G V Y C G F + P + + D+ W
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
Query: 218 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
+ C P + NG V N + + + F C G+ + G + C+
Sbjct: 87 LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
Query: 275 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 325
W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVL--FPLNLQLGAKVDFVCDEGFQ 383
G + ++C WS AAP C+V C + NG + F A V F CD+GF
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 384 LKGSSASYCVLAGMESLWNSSVPVC 408
L GS C S W+ VP C
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKC 283
>gi|27502425 CD46 antigen, complement regulatory protein isoform 8
precursor [Homo sapiens]
Length = 385
Score = 195 bits (496), Expect = 8e-50
Identities = 116/310 (37%), Positives = 155/310 (50%), Gaps = 16/310 (5%)
Query: 1 MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY 60
M PP R E PFPS RFPGLLLAA+VLLL SFSD C P + + IG
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPY-YEIGER 59
Query: 61 LNYECRPGYSGRP---FSIICLKNSVWTSAKDK-CKRKSCRNPPDPVNGMAHVIKDI-QF 115
++Y+C+ GY P IC +N W D C R++C DP+NG A +F
Sbjct: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEF 119
Query: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
Q+ + C +GY LIG C + G+ IW K P+C++++C PP I NG T E
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVE 179
Query: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235
F Y VTY C+ + G F L+GE +IYC +WS AP+C + KC P V
Sbjct: 180 VFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVV 233
Query: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQP---- 291
ENG +S F V F C GF + G + C + + W+P +P C +V P
Sbjct: 234 ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTK 293
Query: 292 PPDVLHAERT 301
PP + H+ T
Sbjct: 294 PPALSHSVST 303
Score = 105 bits (262), Expect = 1e-22
Identities = 61/176 (34%), Positives = 91/176 (51%), Gaps = 6/176 (3%)
Query: 369 QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGM-VHVI 427
++G +VD+ C +G+ A++ + + S C R++C P+NG V
Sbjct: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
Query: 428 TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHT 487
G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG+HT
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT 174
Query: 488 GTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
+ + Y V+Y+CDP P F+LIGESTI N VWS AP C++
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD----NSVWSRAAPECKV 225
Score = 99.4 bits (246), Expect = 8e-21
Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 28/272 (10%)
Query: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--STYLHCTPQGDWS 339
L S S C+ PP E + K + G+ V Y C+ GY +T+ C W
Sbjct: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
Query: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397
P + + ++ NG + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
Query: 398 ESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG---SRINYSCTTG-----HRLIGH 449
++W+ P+CE+ C PP NG H +++ V + YSC LIG
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGE 205
Query: 450 SSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPD 509
S+ C G+ + WS P C+ + C P + NG+ Y V + CD
Sbjct: 206 STIYC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD---- 257
Query: 510 RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
F L G TI S N W P P+C
Sbjct: 258 --KGFYLDGSDTIVCDS----NSTWDPPVPKC 283
Score = 82.4 bits (202), Expect = 1e-15
Identities = 61/233 (26%), Positives = 87/233 (37%), Gaps = 13/233 (5%)
Query: 118 QIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYF 177
++ Y C KGY I + I N C R C NG + Y
Sbjct: 59 RVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTY- 117
Query: 178 HYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVEN 237
+G + + CN G + L+GE +YC K V IWSG P C PP ++N
Sbjct: 118 EFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPPKIKN 170
Query: 238 GILVSDNRSLFSLNEVVEFRCQPG-----FGMKGPSHVKCQALNKWEPELPSCSRVCQPP 292
G +F + V + C P F + G S + C + W P C V
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC 345
P V + ++ F V + C+ G+ L GS + C W P P+C
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 80.1 bits (196), Expect = 5e-15
Identities = 70/265 (26%), Positives = 103/265 (38%), Gaps = 30/265 (11%)
Query: 158 CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217
C PPT + + Y+ G V Y C G F + P + + D+ W
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
Query: 218 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
+ C P + NG V N + + + F C G+ + G + C+
Sbjct: 87 LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
Query: 275 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 325
W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVL--FPLNLQLGAKVDFVCDEGFQ 383
G + ++C WS AAP C+V C + NG + F A V F CD+GF
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 384 LKGSSASYCVLAGMESLWNSSVPVC 408
L GS C S W+ VP C
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKC 283
>gi|27502423 CD46 antigen, complement regulatory protein isoform 2
precursor [Homo sapiens]
Length = 399
Score = 195 bits (496), Expect = 8e-50
Identities = 116/310 (37%), Positives = 155/310 (50%), Gaps = 16/310 (5%)
Query: 1 MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY 60
M PP R E PFPS RFPGLLLAA+VLLL SFSD C P + + IG
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPY-YEIGER 59
Query: 61 LNYECRPGYSGRP---FSIICLKNSVWTSAKDK-CKRKSCRNPPDPVNGMAHVIKDI-QF 115
++Y+C+ GY P IC +N W D C R++C DP+NG A +F
Sbjct: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEF 119
Query: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
Q+ + C +GY LIG C + G+ IW K P+C++++C PP I NG T E
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVE 179
Query: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235
F Y VTY C+ + G F L+GE +IYC +WS AP+C + KC P V
Sbjct: 180 VFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVV 233
Query: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQP---- 291
ENG +S F V F C GF + G + C + + W+P +P C +V P
Sbjct: 234 ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTK 293
Query: 292 PPDVLHAERT 301
PP + H+ T
Sbjct: 294 PPALSHSVST 303
Score = 105 bits (262), Expect = 1e-22
Identities = 61/176 (34%), Positives = 91/176 (51%), Gaps = 6/176 (3%)
Query: 369 QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGM-VHVI 427
++G +VD+ C +G+ A++ + + S C R++C P+NG V
Sbjct: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
Query: 428 TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHT 487
G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG+HT
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT 174
Query: 488 GTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
+ + Y V+Y+CDP P F+LIGESTI N VWS AP C++
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD----NSVWSRAAPECKV 225
Score = 99.4 bits (246), Expect = 8e-21
Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 28/272 (10%)
Query: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--STYLHCTPQGDWS 339
L S S C+ PP E + K + G+ V Y C+ GY +T+ C W
Sbjct: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
Query: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397
P + + ++ NG + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
Query: 398 ESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG---SRINYSCTTG-----HRLIGH 449
++W+ P+CE+ C PP NG H +++ V + YSC LIG
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGE 205
Query: 450 SSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPD 509
S+ C G+ + WS P C+ + C P + NG+ Y V + CD
Sbjct: 206 STIYC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD---- 257
Query: 510 RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
F L G TI S N W P P+C
Sbjct: 258 --KGFYLDGSDTIVCDS----NSTWDPPVPKC 283
Score = 82.4 bits (202), Expect = 1e-15
Identities = 61/233 (26%), Positives = 87/233 (37%), Gaps = 13/233 (5%)
Query: 118 QIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYF 177
++ Y C KGY I + I N C R C NG + Y
Sbjct: 59 RVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTY- 117
Query: 178 HYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVEN 237
+G + + CN G + L+GE +YC K V IWSG P C PP ++N
Sbjct: 118 EFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPPKIKN 170
Query: 238 GILVSDNRSLFSLNEVVEFRCQPG-----FGMKGPSHVKCQALNKWEPELPSCSRVCQPP 292
G +F + V + C P F + G S + C + W P C V
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC 345
P V + ++ F V + C+ G+ L GS + C W P P+C
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 80.1 bits (196), Expect = 5e-15
Identities = 70/265 (26%), Positives = 103/265 (38%), Gaps = 30/265 (11%)
Query: 158 CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217
C PPT + + Y+ G V Y C G F + P + + D+ W
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
Query: 218 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
+ C P + NG V N + + + F C G+ + G + C+
Sbjct: 87 LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
Query: 275 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 325
W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVL--FPLNLQLGAKVDFVCDEGFQ 383
G + ++C WS AAP C+V C + NG + F A V F CD+GF
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 384 LKGSSASYCVLAGMESLWNSSVPVC 408
L GS C S W+ VP C
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKC 283
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 193 bits (490), Expect = 4e-49
Identities = 150/501 (29%), Positives = 211/501 (42%), Gaps = 50/501 (9%)
Query: 50 TDDFEFPIGTYLNYECRPGYSGRPFSII-CLKNSVWTSAKDKCKRKSCRNPPDPVNGMAH 108
T+ EF + +N+ C GY + S C N W+S C+ +C +P N + H
Sbjct: 2750 TNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRH 2809
Query: 109 ----VIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTI 164
+ ++ I Y C KG+ L+GSS+ TC+ +G +WD P C I CG P
Sbjct: 2810 GQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANG---LWDRSLPKCLAISCGHPGVP 2866
Query: 165 ANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQC 224
AN T E F YG+VV Y C RG + L+G + C WSG P C
Sbjct: 2867 ANAVLTG---ELFTYGAVVHYSC----RGSE--SLIGNDTRVCQEDSH----WSGALPHC 2913
Query: 225 I--IPNKCTPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPE 281
P C P +G + D+ F ++ F C+ G ++G C W
Sbjct: 2914 TGNNPGFCGDPGTPAHGSRLGDD---FKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGL 2970
Query: 282 LPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSP 340
P C V C P + D FS V Y+C GY G HCT G W+
Sbjct: 2971 QPVCEAVSCGNPGTPTNGMIVSSDGILFS--SSVIYACWEGYKTSGLMTRHCTANGTWTG 3028
Query: 341 AAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL 400
AP C + SC D G L NG + F + V + C+ G+ ++ +++ + +
Sbjct: 3029 TAPDCTIISCGD-PGTLANG-IQFGTDFTFNKTVSYQCNPGYVMEAVTSA-TIRCTKDGR 3085
Query: 401 WNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNT 460
WN S PVC+ C PP NG V +D GS I+YSC G++L + C G
Sbjct: 3086 WNPSKPVCKAVLCPQPPPVQNGTVEG-SDFRWGSSISYSCMDGYQLSHSAILSCEGRGV- 3143
Query: 461 AHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGES 520
W + P C +FC +P GR +G Y EV + C F L+G S
Sbjct: 3144 --WKGEIPQCLPVFCGDPGIPAEGRLSGK---SFTYKSEVFFQCK------SPFILVGSS 3192
Query: 521 TIRRTSEPHGNGVWSSPAPRC 541
RR + +G WS P C
Sbjct: 3193 --RRVCQ--ADGTWSGIQPTC 3209
Score = 192 bits (489), Expect = 5e-49
Identities = 138/493 (27%), Positives = 205/493 (41%), Gaps = 47/493 (9%)
Query: 63 YECRPGYSGRPFSI-ICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKY 121
Y+C PG+ S+ ICL++ W+ C +C +P +P +G + + + +
Sbjct: 2705 YQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGFTNG-SEFNLNDVVNF 2763
Query: 122 SCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISR--EYFHY 179
+C GY L G S A C +G W + P C + C P + N E F Y
Sbjct: 2764 TCNTGYLLQGVSRAQCRSNGQ---WSSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEY 2820
Query: 180 GSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGI 239
G + YHC KK F L+G ++ C + G+W P+C+ + P N +
Sbjct: 2821 GMSILYHC------KKGFYLLGSSALTCMAN----GLWDRSLPKCLAISCGHPGVPANAV 2870
Query: 240 LVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSR----VCQPPPDV 295
L + LF+ VV + C+ + G CQ + W LP C+ C P
Sbjct: 2871 LTGE---LFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTP 2927
Query: 296 LHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLG 355
H R D+F + +SCE G+ LRGS C G WS P CE SC + G
Sbjct: 2928 AHGSRLG---DDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGN-PG 2983
Query: 356 QLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCET 415
NG ++ + + V + C EG++ G +C G W + P C SC
Sbjct: 2984 TPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGT---WTGTAPDCTIISCGD 3040
Query: 416 PPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFC 475
P NG + TD ++Y C G+ + +SA I W+ P+C+ + C
Sbjct: 3041 PGTLANG-IQFGTDFTFNKTVSYQCNPGYVMEAVTSAT-IRCTKDGRWNPSKPVCKAVLC 3098
Query: 476 PNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWS 535
P PP + NG G+ D +G +SY+C M + S I G GVW
Sbjct: 3099 PQPPPVQNGTVEGS---DFRWGSSISYSC-------MDGYQLSHSAILSC---EGRGVWK 3145
Query: 536 SPAPRCELPVGAG 548
P+C LPV G
Sbjct: 3146 GEIPQC-LPVFCG 3157
Score = 183 bits (464), Expect = 4e-46
Identities = 145/503 (28%), Positives = 208/503 (41%), Gaps = 66/503 (13%)
Query: 58 GTYLNYECRPGYSGRPFSII-CLKNSVWTSAKDK--CKRKSCRNPPDPVNGMAHVIKDIQ 114
G + C PGY + ++ C N W ++ C+ SC + P NG +
Sbjct: 2582 GAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNGNKIGTLTVY 2641
Query: 115 FRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISR 174
+ I ++C GY L+GS C+ +G +W C CG P I NG IS
Sbjct: 2642 GATAI-FTCNTGYTLVGSHVRECLANG---LWSGSETRCLAGHCGSPDPIVNGH---ISG 2694
Query: 175 EYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPN 234
+ F Y V Y CN G F LVG C WSG P C+ P N
Sbjct: 2695 DGFSYRDTVVYQCNPG------FRLVGTSVRICLQDHK----WSGQTPVCVPITCGHPGN 2744
Query: 235 VENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV-CQPPP 293
+G N S F+LN+VV F C G+ ++G S +C++ +W LP+C V C P
Sbjct: 2745 PAHGFT---NGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPG 2801
Query: 294 DVLHAER--TQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCD 351
V +A R Q ++F G + Y C+ G+ L GS+ L C G W + P+C SC
Sbjct: 2802 FVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAISC- 2860
Query: 352 DFLGQLPNGHVLFPLNLQL-------GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSS 404
GH P N L GA V + C L G+ C +S W+ +
Sbjct: 2861 --------GHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVC---QEDSHWSGA 2909
Query: 405 VPVCERKS---CETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTA 461
+P C + C P P +G + D S + +SC GH+L G C+L+G+
Sbjct: 2910 LPHCTGNNPGFCGDPGTPAHGS-RLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGS-- 2966
Query: 462 HWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTC-DPHPDRGMTFNLIGES 520
WS P+C+ + C NP NG + I + V Y C + + G+
Sbjct: 2967 -WSGLQPVCEAVSCGNPGTPTNGMIVSS--DGILFSSSVIYACWEGYKTSGL-------- 3015
Query: 521 TIRRTSEPHGNGVWSSPAPRCEL 543
T NG W+ AP C +
Sbjct: 3016 ---MTRHCTANGTWTGTAPDCTI 3035
Score = 165 bits (418), Expect = 9e-41
Identities = 144/510 (28%), Positives = 214/510 (41%), Gaps = 66/510 (12%)
Query: 54 EFPIGTYLNYECRPGY---SGRPFSIICLKNSVWTSA--KDKCKRKSCRNPPDPVNGMAH 108
EF + + + YEC G+ S + + +C ++ +W++ CK +C P H
Sbjct: 2511 EFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVAC--PSIEAQLSEH 2568
Query: 109 VIKDI------QFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPP 162
VI + ++ +Q+ SC GY L G C +G I D + P C I CG
Sbjct: 2569 VIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDER-PSCRVISCGSLS 2627
Query: 163 TIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAP 222
NG+ YG+ + CN G + LVG C + G+WSG
Sbjct: 2628 FPPNGNKIGTLTV---YGATAIFTCNTG------YTLVGSHVRECLAN----GLWSGSET 2674
Query: 223 QCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPEL 282
+C+ + +P + NG + D FS + V ++C PGF + G S C +KW +
Sbjct: 2675 RCLAGHCGSPDPIVNGHISGDG---FSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQT 2731
Query: 283 PSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPA 341
P C + C P + H + F+ V ++C GY L+G + C G WS
Sbjct: 2732 PVCVPITCGHPGNPAHG---FTNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSP 2788
Query: 342 APRCEVKSCDD---FLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 398
P C V +C D + +G FP + + G + + C +GF L GSSA C+ G
Sbjct: 2789 LPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANG-- 2846
Query: 399 SLWNSSVPVCERKSCETPPVPVNGMVHVITD--IHVGSRINYSCTTGHRLIGHSSAECIL 456
LW+ S+P C SC P VP N V+T G+ ++YSC LIG+ + C
Sbjct: 2847 -LWDRSLPKCLAISCGHPGVPANA---VLTGELFTYGAVVHYSCRGSESLIGNDTRVC-- 2900
Query: 457 SGNTAHWSMKPPIC---QQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCD-PHPDRGM 512
+HWS P C FC +P +G G D + ++C+ H RG
Sbjct: 2901 -QEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLG---DDFKTKSLLRFSCEMGHQLRGS 2956
Query: 513 TFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542
E T NG WS P CE
Sbjct: 2957 P-----ERTCLL------NGSWSGLQPVCE 2975
Score = 155 bits (392), Expect = 9e-38
Identities = 128/438 (29%), Positives = 185/438 (42%), Gaps = 43/438 (9%)
Query: 44 ARPTNLTDDFEFPIGTYLNYECRPGYS--GRPFSIICLKNSVWTSAKDKCKRKSCRNPPD 101
A + L DDF+ + L + C G+ G P CL N W+ + C+ SC NP
Sbjct: 2928 AHGSRLGDDFKTK--SLLRFSCEMGHQLRGSP-ERTCLLNGSWSGLQPVCEAVSCGNPGT 2984
Query: 102 PVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLP 161
P NGM I F S + Y+C +GY+ G + C +G W P C I CG P
Sbjct: 2985 PTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGT---WTGTAPDCTIISCGDP 3041
Query: 162 PTIANG-----DFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGI 216
T+ANG DFT + V+Y CN G V E V +I CT KD G
Sbjct: 3042 GTLANGIQFGTDFT--------FNKTVSYQCNPG----YVMEAVTSATIRCT-KD---GR 3085
Query: 217 WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALN 276
W+ P C PP V+NG + + F + + C G+ + + + C+
Sbjct: 3086 WNPSKPVCKAVLCPQPPPVQNGTVEGSD---FRWGSSISYSCMDGYQLSHSAILSCEGRG 3142
Query: 277 KWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQG 336
W+ E+P C V P + AE K +F+ EVF+ C+ + L GS+ C G
Sbjct: 3143 VWKGEIPQCLPVFCGDPGI-PAEGRLSGK-SFTYKSEVFFQCKSPFILVGSSRRVCQADG 3200
Query: 337 DWSPAAPRC---EVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCV 393
WS P C +C D G G ++G+ V F C +G+ ++GS+ C
Sbjct: 3201 TWSGIQPTCIDPAHNTCPD-PGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTC- 3258
Query: 394 LAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAE 453
LA + W+ C +C P P + V I G + Y+C G L G S
Sbjct: 3259 LANL--TWSGIQTECIPHACRQPETPAHADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHR 3316
Query: 454 CILSGNTAHWSMKPPICQ 471
+ W+ K P+C+
Sbjct: 3317 TCKA--DMKWTGKSPVCK 3332
Score = 154 bits (388), Expect = 3e-37
Identities = 130/444 (29%), Positives = 192/444 (43%), Gaps = 61/444 (13%)
Query: 117 SQIKYSCPKGYRLIGSSSATCIISGNTVI-WDNKTPVCDRIICGLPPTIANGDFTSISRE 175
S++ Y C GYR++G S+ATC + + WD+ TP+C + CG+P + NG FT
Sbjct: 2454 SKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSFTG---N 2510
Query: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWS--GPAPQCIIPNKCTPP 233
F S V Y C+ G F+L E S T+ + G+WS G P C P C P
Sbjct: 2511 EFTLDSKVVYECHEG------FKL--ESSQQATAVCQEDGLWSNKGKPPTC-KPVAC--P 2559
Query: 234 NVENGI-------LVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWE--PELP- 283
++E + LVS SL V C PG+ ++G ++CQA W E P
Sbjct: 2560 SIEAQLSEHVIWRLVSG--SLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPS 2617
Query: 284 ----SCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWS 339
SC + PP T G ++C GY L GS C G WS
Sbjct: 2618 CRVISCGSLSFPPNGNKIGTLTVY-------GATAIFTCNTGYTLVGSHVRECLANGLWS 2670
Query: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES 399
+ RC C + NGH+ V + C+ GF+L G+S C+ +
Sbjct: 2671 GSETRCLAGHCGS-PDPIVNGHISGD-GFSYRDTVVYQCNPGFRLVGTSVRICL---QDH 2725
Query: 400 LWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGN 459
W+ PVC +C P P +G + ++ ++ +N++C TG+ L G S A+C +G
Sbjct: 2726 KWSGQTPVCVPITCGHPGNPAHGFTNG-SEFNLNDVVNFTCNTGYLLQGVSRAQCRSNG- 2783
Query: 460 TAHWSMKPPICQQIFCPNPPAILNG-RHTGTPLGD-IPYGKEVSYTCDPHPDRGMTFNLI 517
WS P C+ + C +P + N RH + YG + Y C F L+
Sbjct: 2784 --QWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCK------KGFYLL 2835
Query: 518 GESTIRRTSEPHGNGVWSSPAPRC 541
G S + + NG+W P+C
Sbjct: 2836 GSSALTCMA----NGLWDRSLPKC 2855
Score = 124 bits (311), Expect = 2e-28
Identities = 145/574 (25%), Positives = 210/574 (36%), Gaps = 101/574 (17%)
Query: 34 QCNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTSAKDKCKR 93
+C P +P A LT+D +F IG ++ Y+C PGY+ I+ K S +
Sbjct: 2258 KCQPPPAVPQAEM--LTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPT 2315
Query: 94 KSCRNPPDPV-NGMAHVI-----KDIQFRSQI------------------KYSCPKGYRL 129
+ P + V G + VI F SQ + K +
Sbjct: 2316 CEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQFDA 2375
Query: 130 I-------GSSSATCIISGNTVIWDNKTPVCDRI----------------------ICGL 160
+ G S ++SGN N T +++ C L
Sbjct: 2376 LEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAAPYCSL 2435
Query: 161 PPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGP 220
+ NG ++R GS V Y C G + +VG + C + W
Sbjct: 2436 THPLKNGGI--LNRTAGAVGSKVHYFCKPG------YRMVGHSNATCRRNPLGMYQWDSL 2487
Query: 221 APQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVK--CQALNKW 278
P C + P + NG + F+L+ V + C GF ++ CQ W
Sbjct: 2488 TPLCQAVSCGIPESPGNGSFTGNE---FTLDSKVVYECHEGFKLESSQQATAVCQEDGLW 2544
Query: 279 --EPELPSCSRVCQPPPDVLHAE----RTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHC 332
+ + P+C V P + +E R N G +V SC PGY L G L C
Sbjct: 2545 SNKGKPPTCKPVACPSIEAQLSEHVIWRLVSGSLN-EYGAQVLLSCSPGYYLEGWRLLRC 2603
Query: 333 TPQGDWS--PAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSAS 390
G W+ P C V SC L PNG+ + L + GA F C+ G+ L GS
Sbjct: 2604 QANGTWNIGDERPSCRVISCGS-LSFPPNGNKIGTLTV-YGATAIFTCNTGYTLVGSHVR 2661
Query: 391 YCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITD-IHVGSRINYSCTTGHRLIGH 449
C+ G LW+ S C C +P VNG H+ D + Y C G RL+G
Sbjct: 2662 ECLANG---LWSGSETRCLAGHCGSPDPIVNG--HISGDGFSYRDTVVYQCNPGFRLVGT 2716
Query: 450 SSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPD 509
S C+ WS + P+C I C +P N H T + V++TC +
Sbjct: 2717 SVRICL---QDHKWSGQTPVCVPITCGHPG---NPAHGFTNGSEFNLNDVVNFTC----N 2766
Query: 510 RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
G + + R NG WSSP P C +
Sbjct: 2767 TGYLLQGVSRAQCR------SNGQWSSPLPTCRV 2794
Score = 103 bits (258), Expect = 3e-22
Identities = 135/518 (26%), Positives = 199/518 (38%), Gaps = 97/518 (18%)
Query: 94 KSCRNPPD-PVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPV 152
K C+ PP P M D + +KY C GY L+G+ TC +S + ++ P
Sbjct: 2257 KKCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQ-LQFEGSLPT 2315
Query: 153 CDR---------------IICGLPPTIANGDFTS----ISREYFHYGSVVTYHCNL---- 189
C+ + G P N S + Y V T+
Sbjct: 2316 CEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQFDA 2375
Query: 190 -----GSRGKKVFELV-----GEPSIYCTSKDDQVGI-WSGP-------------APQCI 225
GS G+ +V E S + TS+ +Q+ + WS AP C
Sbjct: 2376 LEVFDGSSGQSPLLVVLSGNHTEQSNF-TSRSNQLYLRWSTDHATSKKGFKIRYAAPYCS 2434
Query: 226 IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQ----ALNKWEPE 281
+ T P GIL NR+ ++ V + C+PG+ M G S+ C+ + +W+
Sbjct: 2435 L----THPLKNGGIL---NRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSL 2487
Query: 282 LPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLH--CTPQGDW 338
P C V C P + T + F+ +V Y C G+ L S C G W
Sbjct: 2488 TPLCQAVSCGIPESPGNGSFTGNE---FTLDSKVVYECHEGFKLESSQQATAVCQEDGLW 2544
Query: 339 SPAA--PRCEVKSCDDFLGQLPNGHVLFPLNL----QLGAKVDFVCDEGFQLKGSSASYC 392
S P C+ +C QL + HV++ L + GA+V C G+ L+G C
Sbjct: 2545 SNKGKPPTCKPVACPSIEAQL-SEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRC 2603
Query: 393 VLAGMESLWN--SSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHS 450
G WN P C SC + P NG + T G+ ++C TG+ L+G
Sbjct: 2604 QANG---TWNIGDERPSCRVISCGSLSFPPNGN-KIGTLTVYGATAIFTCNTGYTLVGSH 2659
Query: 451 SAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDR 510
EC+ +G WS C C +P I+NG +G Y V Y C+P
Sbjct: 2660 VRECLANG---LWSGSETRCLAGHCGSPDPIVNGHISG---DGFSYRDTVVYQCNP---- 2709
Query: 511 GMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVGAG 548
F L+G S +R + H WS P C +P+ G
Sbjct: 2710 --GFRLVGTS-VRICLQDH---KWSGQTPVC-VPITCG 2740
Score = 81.6 bits (200), Expect = 2e-15
Identities = 125/519 (24%), Positives = 190/519 (36%), Gaps = 101/519 (19%)
Query: 94 KSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVC 153
++C +PP NG + D + + C GY LIG TC G W+ P C
Sbjct: 2086 QNCPDPPPFQNGYM-INSDYSVGQSVSFECYPGYILIGHPVLTCQ-HGINRNWNYPFPRC 2143
Query: 154 DRIICGLPPTIANGDFTS--ISREYFHYGSVVTYHCNLGSRGKKV-FELVGEPSIYCTSK 210
D CG T NG S EY + G + F L+ ++
Sbjct: 2144 DAP-CGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAV----- 2197
Query: 211 DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL---FSLNEVVEFRCQPGFGMKGP 267
+D + +W GP + + G+ S N +L +S V + F G
Sbjct: 2198 NDYIAVWDGPDQN----------SPQLGVF-SGNTALETAYSSTNQVLLKFHSDFSNGGF 2246
Query: 268 SHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGS 327
+ A + CQPPP V AE D D+F G V Y C PGY L G+
Sbjct: 2247 FVLNFHAFQL---------KKCQPPPAVPQAEMLTED-DDFEIGDFVKYQCHPGYTLVGT 2296
Query: 328 TYLHC--TPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFP-------------------L 366
L C + Q + + P CE + + + +G +L P
Sbjct: 2297 DILTCKLSSQLQFEGSLPTCEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEP 2356
Query: 367 NLQLGAKVD-FVCDEGFQL-------KGSSASYCVLAGMES--------------LWNSS 404
N + VD F ++ F G S VL+G + W++
Sbjct: 2357 NYNITIFVDTFQSEKQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTD 2416
Query: 405 VPVCERKSCETPPVPVNGMVHVI--------TDIHVGSRINYSCTTGHRLIGHSSAECIL 456
++ P + H + T VGS+++Y C G+R++GHS+A C
Sbjct: 2417 HATSKKGFKIRYAAPYCSLTHPLKNGGILNRTAGAVGSKVHYFCKPGYRMVGHSNATCRR 2476
Query: 457 SG-NTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFN 515
+ W P+CQ + C P + NG TG + +V Y C F
Sbjct: 2477 NPLGMYQWDSLTPLCQAVSCGIPESPGNGSFTG---NEFTLDSKVVYECHE------GFK 2527
Query: 516 LIGESTIRRTSEPHGNGVWSSPA--PRCELPVGAGSHDA 552
L ES+ + T+ +G+WS+ P C+ PV S +A
Sbjct: 2528 L--ESSQQATAVCQEDGLWSNKGKPPTCK-PVACPSIEA 2563
Score = 78.2 bits (191), Expect = 2e-14
Identities = 103/438 (23%), Positives = 165/438 (37%), Gaps = 88/438 (20%)
Query: 93 RKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGN-TVIWDNKTP 151
R++C +P + +NG V D + S I Y C GY+++ SS TC+I + WD P
Sbjct: 1562 REACFDPGNIMNG-TRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLP 1620
Query: 152 VCDRIICGLPPTIANGDFTSISREYFHY---GSVVTYHCNLGSRGKKVFELVGEPSIYCT 208
C+ CG T + G +S Y H G + Y + K F + G+ + + T
Sbjct: 1621 SCNAP-CGGQYTGSEG--VVLSPNYPHNYTAGQICLYSITV----PKEFVVFGQFAYFQT 1673
Query: 209 SKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVV-EFRCQPGFGMKGP 267
+ +D ++ G Q + + + G + L + N+++ F + G +G
Sbjct: 1674 ALNDLAELFDGTHAQARLLSSLS------GSHSGETLPLATSNQILLRFSAKSGASARG- 1726
Query: 268 SHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGS 327
H QA+ + CS V +P +R FS G V + C PGY L+GS
Sbjct: 1727 FHFVYQAVPRTSDT--QCSSVPEP-------RYGRRIGSEFSAGSIVRFECNPGYLLQGS 1777
Query: 328 TYLHC----TPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFP-------LNLQLGAKVDF 376
T LHC W+ P C V +F + G +L P NL K+
Sbjct: 1778 TALHCQSVPNALAQWNDTIPSCVVPCSGNFTQR--RGTILSPGYPEPYGNNLNCIWKIIV 1835
Query: 377 VCDEGFQLK--------------------------GSSASYCVLAGMESLWN-------S 403
G Q++ GS + V A + S N S
Sbjct: 1836 TEGSGIQIQVISFATEQNWDSLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQS 1895
Query: 404 SVPVCER-----------KSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSA 452
+ V +C+ P +P N + + V +++ C G+ L G S
Sbjct: 1896 DISVAAAGFHLEYKTVGLAACQEPALPSNS-IKIGDRYMVNDVLSFQCEPGYTLQGRSHI 1954
Query: 453 ECILSGNTAHWSMKPPIC 470
C + G W+ P+C
Sbjct: 1955 SC-MPGTVRRWNYPSPLC 1971
Score = 57.8 bits (138), Expect = 3e-08
Identities = 92/427 (21%), Positives = 150/427 (35%), Gaps = 90/427 (21%)
Query: 119 IKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFH 178
+ YSC GY + GS++ TC+ SG+ +WD P C G +G S +
Sbjct: 1241 VLYSCNPGYAMHGSNTLTCL-SGDRRVWDKPLPSCIAECGGQIHAATSGRILSPGYPAPY 1299
Query: 179 YGSVVTYHCNLGSRGKKVFELVGEPSIYCTSK-DDQVGIWSGPAPQCIIPNKCTPPNVEN 237
++ HC + ++ T D + +W GP I+ + + +
Sbjct: 1300 DNNL---HCTWIIEADPGKTISLHFIVFDTEMAHDILKVWDGPVDSDILLKEWSGSALPE 1356
Query: 238 GILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLH 297
I + N + F + GF ++ + + A +P +P
Sbjct: 1357 DIHSTFNSLTLQFDSDF-FISKSGFSIQFSTSI---AATCNDPGMP-------------- 1398
Query: 298 AERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGD---WSPAAPRCEVKSCDDFL 354
+ R D+ G V + C+PGY L+G + C + W P P C +
Sbjct: 1399 -QNGTRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACGGNLT 1457
Query: 355 GQLPNGHVLFP-----------LNLQLGAKVDFVC----------------------DEG 381
G P G +L P + ++ DFV D
Sbjct: 1458 G--PAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHIYEGEDSN 1515
Query: 382 FQLKGSSASYCVLAGMESLWNS---------SVPVC---------ERKSCETPPVPVNGM 423
L GS +ES NS SV + R++C P +NG
Sbjct: 1516 SPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREACFDPGNIMNG- 1574
Query: 424 VHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGN-TAHWSMKPPICQQIFCPNPPAIL 482
V TD +GS I Y C +G++++ SS C++ + W P C N P
Sbjct: 1575 TRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSC------NAPC-- 1626
Query: 483 NGRHTGT 489
G++TG+
Sbjct: 1627 GGQYTGS 1633
Score = 56.6 bits (135), Expect = 6e-08
Identities = 98/444 (22%), Positives = 151/444 (34%), Gaps = 103/444 (23%)
Query: 93 RKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGY-RLIGSSSATCIISGNTVIWDNKTP 151
+ C +P P+NG + + S + + C G+ + GS S TCI+ V+W + P
Sbjct: 695 QNECHDPGIPINGRRFGDRFL-LGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVP 753
Query: 152 VCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNL------GSRGKKVFELVGEPSI 205
C+ CG T ++G ++ S+ HC G K F+
Sbjct: 754 RCE-APCGGHLTASSGVILPPGWPGYYKDSL---HCEWIIEAKPGHSIKITFDRFQTEVN 809
Query: 206 YCT--------SKDDQVGIWSG-PAPQCII------------------------------ 226
Y T S +G + G APQ +I
Sbjct: 810 YDTLEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVTL 869
Query: 227 -PNKCTPPNVENGILVSDNR--SLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELP 283
+ C P GI V+ +R F + V F C PG+ + + C+ ++W LP
Sbjct: 870 ESDSCLDP----GIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALP 925
Query: 284 SCSRVCQPPPDVLHAERTQRDKDNFSPG----------------QEVFYSCEPGYDLRGS 327
SC +C +F P Q +F++ + L S
Sbjct: 926 SCDALCGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHT----FHLESS 981
Query: 328 -TYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKG 386
YL T G +S R G VL P ++ G +F F +
Sbjct: 982 HDYLLITEDGSFSEPVARL-------------TGSVL-PHTIKAGLFGNFTAQLRF-ISD 1026
Query: 387 SSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRL 446
S SY +N + + + C+ P VP + VG + +SC G+RL
Sbjct: 1027 FSISY-------EGFNITFSEYDLEPCDDPGVPAFSR-RIGFHFGVGDSLTFSCFLGYRL 1078
Query: 447 IGHSSAECILSGNTAHWSMKPPIC 470
G + C L G WS P C
Sbjct: 1079 EGATKLTC-LGGGRRVWSAPLPRC 1101
Score = 52.8 bits (125), Expect = 9e-07
Identities = 70/307 (22%), Positives = 108/307 (35%), Gaps = 62/307 (20%)
Query: 229 KCTPPNVEN-GILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNK--WEPELPSC 285
KC P + N G + D + VV + C PG+ M G + + C + ++ W+ LPSC
Sbjct: 1217 KCEDPGIPNYGYRIRDEGHF--TDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSC 1274
Query: 286 SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC 345
C +HA + R PGY LHCT W A
Sbjct: 1275 IAEC---GGQIHAATSGR-------------ILSPGYPAPYDNNLHCT----WIIEADPG 1314
Query: 346 EVKSCDDFLGQLPNGHVLF-----PLNLQL------GAKVDFVCDEGFQ---LKGSSASY 391
+ S + H + P++ + G+ + F L+ S +
Sbjct: 1315 KTISLHFIVFDTEMAHDILKVWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFDSDFF 1374
Query: 392 CVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSS 451
+G +++S+ +C P +P NG G + + C G++L G +
Sbjct: 1375 ISKSGFSIQFSTSIAA----TCNDPGMPQNG-TRYGDSREAGDTVTFQCDPGYQLQGQAK 1429
Query: 452 AECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDI---------PYGKEVSY 502
C+ N W PP C A G TG P G I P GKE +
Sbjct: 1430 ITCVQLNNRFFWQPDPPTC--------IAACGGNLTG-PAGVILSPNYPQPYPPGKECDW 1480
Query: 503 TCDPHPD 509
+PD
Sbjct: 1481 RVKVNPD 1487
Score = 51.6 bits (122), Expect = 2e-06
Identities = 106/458 (23%), Positives = 157/458 (34%), Gaps = 102/458 (22%)
Query: 95 SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIIS-GNTVIWDNKTPVC 153
+C NP + + G+ H + +I+YSC GY L G + TCI+S GN WD P C
Sbjct: 144 TCGNPGEILKGVLHGTR-FNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFC 202
Query: 154 -DRIICGLPPTIANGDFTSISREYFHYGSVVTYHCN---LGSRGKKV------FELVGEP 203
CG G +SIS +F C L G + F+L
Sbjct: 203 RAEGACG---GTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGY 259
Query: 204 SIYCTSKDDQVGIW--SGPAPQCIIPNKCTPPNVENGILVSDN-------RSLFSLNEVV 254
S + IW P +I +K N SD+ + F + + +
Sbjct: 260 DFLEISGTEAPSIWLTGMNLPSPVISSK----NWLRLHFTSDSNHRRKGFNAQFQVKKAI 315
Query: 255 EFRCQPGFGM---KGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFS-P 310
E + + G M K SH K L++ L S +C PD E +R +FS
Sbjct: 316 ELKSR-GVKMLPSKDGSH-KNSVLSQGGVAL--VSDMC---PDPGIPENGRRAGSDFSRV 368
Query: 311 GQEVFYSCEPGYDLRGSTYLHCTPQGD----WSPAAPRCEVKSCDDFLGQLPNGHVLFP- 365
G V +SCE Y L+GS + C + WS P C ++C L + P+G + P
Sbjct: 369 GANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNL-RGPSGVITSPN 427
Query: 366 ------------------------------LNLQLGAKVDFVCDEG---------FQLKG 386
L+ G V D G + L G
Sbjct: 428 YPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTG 487
Query: 387 SSASYCVLAGMESLW--------------NSSVPVCERKSCETPPVPVNGMVHVITDIHV 432
SS +++ +W + E+ C P +P G + +H
Sbjct: 488 SSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRTGSSFLH- 546
Query: 433 GSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPIC 470
G + + C L+G C WS P C
Sbjct: 547 GDTLTFECPAAFELVGERVITC---QQNNQWSGNKPSC 581
Score = 49.7 bits (117), Expect = 7e-06
Identities = 91/441 (20%), Positives = 140/441 (31%), Gaps = 97/441 (21%)
Query: 95 SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCD 154
+C +P P NG + + + + C GY+L G + TC+ N W P C
Sbjct: 1391 TCNDPGMPQNGTRYG-DSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTC- 1448
Query: 155 RIICG------------------LPP-------TIANGDFT----------SISREYFHY 179
CG PP N DF S ++ H
Sbjct: 1449 IAACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHI 1508
Query: 180 GSVVTYHCNL-----GSRGKKVFELVGEPSIYCTSKDDQVGIWSG--------PAPQCII 226
+ L GS+ + E G D VG+ SG P C
Sbjct: 1509 YEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGL-SGFAIEFKEKPREACF- 1566
Query: 227 PNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKC----QALNKWEPEL 282
P N+ NG V + F L + ++C G+ + PS + C W+ L
Sbjct: 1567 ----DPGNIMNGTRVGTD---FKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVL 1619
Query: 283 PSCSRVCQP----------PPDVLHAERTQRDKDNFSPGQEVFYS--CEPGYDLRGSTYL 330
PSC+ C P+ H N++ GQ YS + + G
Sbjct: 1620 PSCNAPCGGQYTGSEGVVLSPNYPH---------NYTAGQICLYSITVPKEFVVFGQFAY 1670
Query: 331 HCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSAS 390
T D + ++ L L H G + L+ S+ S
Sbjct: 1671 FQTALNDLAELFDGTHAQA--RLLSSLSGSH--------SGETLPLATSNQILLRFSAKS 1720
Query: 391 YCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHS 450
G ++ +VP C + P P G + ++ GS + + C G+ L G +
Sbjct: 1721 GASARGFHFVY-QAVPRTSDTQCSSVPEPRYGR-RIGSEFSAGSIVRFECNPGYLLQGST 1778
Query: 451 SAECILSGNT-AHWSMKPPIC 470
+ C N A W+ P C
Sbjct: 1779 ALHCQSVPNALAQWNDTIPSC 1799
Score = 47.4 bits (111), Expect = 4e-05
Identities = 100/472 (21%), Positives = 162/472 (34%), Gaps = 104/472 (22%)
Query: 61 LNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIK 120
L + + G S R F + A + C + P+P G + + S ++
Sbjct: 1714 LRFSAKSGASARGFHFVY-------QAVPRTSDTQCSSVPEPRYGR-RIGSEFSAGSIVR 1765
Query: 121 YSCPKGYRLIGSSSATCIISGNTVI-WDNKTPVCDRIICGLPPTIANGDFTSISREYFHY 179
+ C GY L GS++ C N + W++ P C + C +G+FT
Sbjct: 1766 FECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCV-VPC-------SGNFTQRRGTILSP 1817
Query: 180 GSVVTYHCNLGSRGKKVFELVGEPSI----YCTSKD-DQVGIWSG---PAPQCIIPNKCT 231
G Y NL K + I + T ++ D + I G AP+ + T
Sbjct: 1818 GYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLEIHDGGDVTAPRLGSFSGTT 1877
Query: 232 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQP 291
P + N S+ L +++ K CQ EP LPS S
Sbjct: 1878 VPALLNS--TSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQ-----EPALPSNSI---- 1926
Query: 292 PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQG--DWSPAAPRCEVKS 349
+ D + + + CEPGY L+G +++ C P W+ +P C + +
Sbjct: 1927 -----------KIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLC-IAT 1974
Query: 350 CDD-------------FLGQLPNG---------------HVLFPLNLQLGAKVDFVCDEG 381
C F G PN H+ F LN A DF+ +
Sbjct: 1975 CGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQF-LNFSTEANHDFLEIQN 2033
Query: 382 F---------QLKGSSASYCVLAGMESL--------------WNSSVPVCERKSCETPPV 418
Q G+ +L+ + + E ++C PP
Sbjct: 2034 GPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNCPDPPP 2093
Query: 419 PVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPIC 470
NG + + +D VG +++ C G+ LIGH C G +W+ P C
Sbjct: 2094 FQNGYM-INSDYSVGQSVSFECYPGYILIGHPVLTC-QHGINRNWNYPFPRC 2143
Score = 46.6 bits (109), Expect = 6e-05
Identities = 23/61 (37%), Positives = 34/61 (55%), Gaps = 2/61 (3%)
Query: 412 SCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILS-GNTAHWSMKPPIC 470
+C P + G++H T ++G +I YSC G+ L GH+ CI+S GN A W P C
Sbjct: 144 TCGNPGEILKGVLHG-TRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFC 202
Query: 471 Q 471
+
Sbjct: 203 R 203
Score = 43.9 bits (102), Expect = 4e-04
Identities = 93/461 (20%), Positives = 150/461 (32%), Gaps = 106/461 (22%)
Query: 80 KNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCI- 138
KNSV + C +P P NG + + +++SC Y L GS S TC
Sbjct: 333 KNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQR 392
Query: 139 ISGNTVIWDNKTPV-----CDRIICGLPPTIANGDFTSISREYFHYGSVVTYH------- 186
++ W + P+ C + G I + ++ + H V+T
Sbjct: 393 VTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIK 452
Query: 187 --------------CNLGSRGKK------VFELVGE--PSIYCT---------SKDDQVG 215
+G GK ++ L G P + + DD +G
Sbjct: 453 LAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIG 512
Query: 216 IWSGPAP-QCIIPNKCTPPNVENGILVSDNR--SLFSLNEVVEFRCQPGFGMKGPSHVKC 272
A Q I C P GI R S F + + F C F + G + C
Sbjct: 513 SPGFKAVYQEIEKGGCGDP----GIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITC 568
Query: 273 QALNKWEPELPSCSRVC-----QPPPDVLHAERTQRDKDNFS--------PGQEVF---- 315
Q N+W PSC C +L + +N + PG +
Sbjct: 569 QQNNQWSGNKPSCVFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFN 628
Query: 316 -YSCEPGYD---LRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLG 371
+ EP +D ++ T G +S ++ S +GH++
Sbjct: 629 DFDVEPQFDFLAVKDDGISDITVLGTFSGNEVPSQLAS---------SGHIV-------- 671
Query: 372 AKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIH 431
+++F D +G + +Y E C P +P+NG
Sbjct: 672 -RLEFQSDHSTTGRGFNITYTTFGQNE--------------CHDPGIPINGR-RFGDRFL 715
Query: 432 VGSRINYSCTTGH-RLIGHSSAECILSGNTAHWSMKPPICQ 471
+GS +++ C G + G S CIL WS P C+
Sbjct: 716 LGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCE 756
Score = 38.1 bits (87), Expect = 0.022
Identities = 49/261 (18%), Positives = 91/261 (34%), Gaps = 28/261 (10%)
Query: 289 CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGD----WSPAAPR 344
C P ++++ R D F G + Y C+ GY + + + C D W P
Sbjct: 1565 CFDPGNIMNGTRVGTD---FKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPS 1621
Query: 345 CEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSS 404
C + G G VL P N +C + + A ++ N
Sbjct: 1622 CNAPCGGQYTGS--EGVVLSP-NYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDL 1678
Query: 405 VPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWS 464
+ + + ++ ++ H G + + T ++++ SA+ S H+
Sbjct: 1679 AELFDGTHAQAR------LLSSLSGSHSGETLPLA--TSNQILLRFSAKSGASARGFHFV 1730
Query: 465 MKP-PICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIR 523
+ P C + P GR G+ + G V + C+P + L G + +
Sbjct: 1731 YQAVPRTSDTQCSSVPEPRYGRRIGS---EFSAGSIVRFECNPG------YLLQGSTALH 1781
Query: 524 RTSEPHGNGVWSSPAPRCELP 544
S P+ W+ P C +P
Sbjct: 1782 CQSVPNALAQWNDTIPSCVVP 1802
Score = 35.0 bits (79), Expect = 0.18
Identities = 26/72 (36%), Positives = 30/72 (41%), Gaps = 9/72 (12%)
Query: 475 CPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVW 534
C +P +NGR G G VS+ CD G ES + GN VW
Sbjct: 698 CHDPGIPINGRRFGDRF---LLGSSVSFHCDD----GFVKTQGSESITCILQD--GNVVW 748
Query: 535 SSPAPRCELPVG 546
SS PRCE P G
Sbjct: 749 SSTVPRCEAPCG 760
Score = 34.7 bits (78), Expect = 0.24
Identities = 20/64 (31%), Positives = 28/64 (43%), Gaps = 1/64 (1%)
Query: 413 CETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAEC-ILSGNTAHWSMKPPICQ 471
C P +P NG VG+ + +SC + L G S C ++ A WS PIC+
Sbjct: 349 CPDPGIPENGRRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICR 408
Query: 472 QIFC 475
C
Sbjct: 409 ARTC 412
Score = 33.9 bits (76), Expect = 0.41
Identities = 59/261 (22%), Positives = 90/261 (34%), Gaps = 41/261 (15%)
Query: 228 NKCTPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGF-GMKGPSHVKCQALNK---WEPEL 282
N+C P + NG D F L V F C GF +G + C + W +
Sbjct: 696 NECHDPGIPINGRRFGDR---FLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTV 752
Query: 283 PSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYS----CE------PGYDLRGSTYLHC 332
P C C T PG +Y CE PG+ ++ T+
Sbjct: 753 PRCEAPCG-------GHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIK-ITFDRF 804
Query: 333 TPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYC 392
+ ++ R S +G+ +G + G + + F S +S
Sbjct: 805 QTEVNYDTLEVRDGPASSSPLIGEY-HGTQAPQFLISTGNFMYLL----FTTDNSRSSIG 859
Query: 393 VLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSA 452
L ES+ E SC P +PVNG H D + S + +SC G+ L S
Sbjct: 860 FLIHYESV------TLESDSCLDPGIPVNGHRHG-GDFGIRSTVTFSCDPGYTL---SDD 909
Query: 453 ECILSGNTAHWSMKPPICQQI 473
E ++ W+ P C +
Sbjct: 910 EPLVCERNHQWNHALPSCDAL 930
Score = 33.5 bits (75), Expect = 0.54
Identities = 66/307 (21%), Positives = 101/307 (32%), Gaps = 92/307 (29%)
Query: 286 SRVCQPPPD----VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQ----GD 337
S C P + VLH R F+ G ++ YSC PGY L G L C
Sbjct: 142 SHTCGNPGEILKGVLHGTR-------FNIGDKIRYSCLPGYILEGHAILTCIVSPGNGAS 194
Query: 338 WSPAAPRCEVK-SCDDFL----GQLPNGHVLFPLNLQLGAK-----------------VD 375
W AP C + +C L + + H FP + A D
Sbjct: 195 WDFPAPFCRAEGACGGTLRGTSSSISSPH--FPSEYENNADCTWTILAEPGDTIALVFTD 252
Query: 376 FVCDEGF---QLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHV 432
F +EG+ ++ G+ A L GM N PV K+
Sbjct: 253 FQLEEGYDFLEISGTEAPSIWLTGM----NLPSPVISSKN-------------------- 288
Query: 433 GSRINYSCTTGHRLIGHSS--------------AECILSGNTAH----WSMKPPICQQIF 474
R++++ + HR G ++ + + S + +H S
Sbjct: 289 WLRLHFTSDSNHRRKGFNAQFQVKKAIELKSRGVKMLPSKDGSHKNSVLSQGGVALVSDM 348
Query: 475 CPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVW 534
CP+P NGR G+ + G V ++C+ + + L G +I W
Sbjct: 349 CPDPGIPENGRRAGSDFSRV--GANVQFSCEDN------YVLQGSKSITCQRVTETLAAW 400
Query: 535 SSPAPRC 541
S P C
Sbjct: 401 SDHRPIC 407
>gi|27502421 CD46 antigen, complement regulatory protein isoform 13
precursor [Homo sapiens]
Length = 373
Score = 191 bits (484), Expect = 2e-48
Identities = 111/293 (37%), Positives = 148/293 (50%), Gaps = 12/293 (4%)
Query: 1 MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY 60
M PP R E PFPS RFPGLLLAA+VLLL SFSD C P + + IG
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPY-YEIGER 59
Query: 61 LNYECRPGYSGRP---FSIICLKNSVWTSAKDK-CKRKSCRNPPDPVNGMAHVIKDI-QF 115
++Y+C+ GY P IC +N W D C R++C DP+NG A +F
Sbjct: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEF 119
Query: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
Q+ + C +GY LIG C + G+ IW K P+C++++C PP I NG T E
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVE 179
Query: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235
F Y VTY C+ + G F L+GE +IYC +WS AP+C + KC P V
Sbjct: 180 VFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVV 233
Query: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV 288
ENG +S F V F C GF + G + C + + W+P +P C +V
Sbjct: 234 ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
Score = 105 bits (262), Expect = 1e-22
Identities = 61/176 (34%), Positives = 91/176 (51%), Gaps = 6/176 (3%)
Query: 369 QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGM-VHVI 427
++G +VD+ C +G+ A++ + + S C R++C P+NG V
Sbjct: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
Query: 428 TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHT 487
G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG+HT
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT 174
Query: 488 GTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
+ + Y V+Y+CDP P F+LIGESTI N VWS AP C++
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD----NSVWSRAAPECKV 225
Score = 99.4 bits (246), Expect = 8e-21
Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 28/272 (10%)
Query: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--STYLHCTPQGDWS 339
L S S C+ PP E + K + G+ V Y C+ GY +T+ C W
Sbjct: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
Query: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397
P + + ++ NG + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
Query: 398 ESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG---SRINYSCTTG-----HRLIGH 449
++W+ P+CE+ C PP NG H +++ V + YSC LIG
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGE 205
Query: 450 SSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPD 509
S+ C G+ + WS P C+ + C P + NG+ Y V + CD
Sbjct: 206 STIYC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD---- 257
Query: 510 RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
F L G TI S N W P P+C
Sbjct: 258 --KGFYLDGSDTIVCDS----NSTWDPPVPKC 283
Score = 82.4 bits (202), Expect = 1e-15
Identities = 61/233 (26%), Positives = 87/233 (37%), Gaps = 13/233 (5%)
Query: 118 QIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYF 177
++ Y C KGY I + I N C R C NG + Y
Sbjct: 59 RVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTY- 117
Query: 178 HYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVEN 237
+G + + CN G + L+GE +YC K V IWSG P C PP ++N
Sbjct: 118 EFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPPKIKN 170
Query: 238 GILVSDNRSLFSLNEVVEFRCQPG-----FGMKGPSHVKCQALNKWEPELPSCSRVCQPP 292
G +F + V + C P F + G S + C + W P C V
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC 345
P V + ++ F V + C+ G+ L GS + C W P P+C
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 80.5 bits (197), Expect = 4e-15
Identities = 71/269 (26%), Positives = 105/269 (39%), Gaps = 30/269 (11%)
Query: 158 CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217
C PPT + + Y+ G V Y C G F + P + + D+ W
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
Query: 218 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
+ C P + NG V N + + + F C G+ + G + C+
Sbjct: 87 LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
Query: 275 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 325
W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVL--FPLNLQLGAKVDFVCDEGFQ 383
G + ++C WS AAP C+V C + NG + F A V F CD+GF
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 384 LKGSSASYCVLAGMESLWNSSVPVCERKS 412
L GS C S W+ VP C + S
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVS 287
>gi|27502417 CD46 antigen, complement regulatory protein isoform 10
precursor [Homo sapiens]
Length = 370
Score = 191 bits (484), Expect = 2e-48
Identities = 111/293 (37%), Positives = 148/293 (50%), Gaps = 12/293 (4%)
Query: 1 MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY 60
M PP R E PFPS RFPGLLLAA+VLLL SFSD C P + + IG
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPY-YEIGER 59
Query: 61 LNYECRPGYSGRP---FSIICLKNSVWTSAKDK-CKRKSCRNPPDPVNGMAHVIKDI-QF 115
++Y+C+ GY P IC +N W D C R++C DP+NG A +F
Sbjct: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEF 119
Query: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
Q+ + C +GY LIG C + G+ IW K P+C++++C PP I NG T E
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVE 179
Query: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235
F Y VTY C+ + G F L+GE +IYC +WS AP+C + KC P V
Sbjct: 180 VFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVV 233
Query: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV 288
ENG +S F V F C GF + G + C + + W+P +P C +V
Sbjct: 234 ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
Score = 105 bits (262), Expect = 1e-22
Identities = 61/176 (34%), Positives = 91/176 (51%), Gaps = 6/176 (3%)
Query: 369 QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGM-VHVI 427
++G +VD+ C +G+ A++ + + S C R++C P+NG V
Sbjct: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
Query: 428 TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHT 487
G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG+HT
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT 174
Query: 488 GTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
+ + Y V+Y+CDP P F+LIGESTI N VWS AP C++
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD----NSVWSRAAPECKV 225
Score = 99.4 bits (246), Expect = 8e-21
Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 28/272 (10%)
Query: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--STYLHCTPQGDWS 339
L S S C+ PP E + K + G+ V Y C+ GY +T+ C W
Sbjct: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
Query: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397
P + + ++ NG + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
Query: 398 ESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG---SRINYSCTTG-----HRLIGH 449
++W+ P+CE+ C PP NG H +++ V + YSC LIG
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGE 205
Query: 450 SSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPD 509
S+ C G+ + WS P C+ + C P + NG+ Y V + CD
Sbjct: 206 STIYC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD---- 257
Query: 510 RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
F L G TI S N W P P+C
Sbjct: 258 --KGFYLDGSDTIVCDS----NSTWDPPVPKC 283
Score = 82.4 bits (202), Expect = 1e-15
Identities = 61/233 (26%), Positives = 87/233 (37%), Gaps = 13/233 (5%)
Query: 118 QIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYF 177
++ Y C KGY I + I N C R C NG + Y
Sbjct: 59 RVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTY- 117
Query: 178 HYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVEN 237
+G + + CN G + L+GE +YC K V IWSG P C PP ++N
Sbjct: 118 EFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPPKIKN 170
Query: 238 GILVSDNRSLFSLNEVVEFRCQPG-----FGMKGPSHVKCQALNKWEPELPSCSRVCQPP 292
G +F + V + C P F + G S + C + W P C V
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC 345
P V + ++ F V + C+ G+ L GS + C W P P+C
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 80.5 bits (197), Expect = 4e-15
Identities = 71/269 (26%), Positives = 105/269 (39%), Gaps = 30/269 (11%)
Query: 158 CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217
C PPT + + Y+ G V Y C G F + P + + D+ W
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
Query: 218 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
+ C P + NG V N + + + F C G+ + G + C+
Sbjct: 87 LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
Query: 275 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 325
W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVL--FPLNLQLGAKVDFVCDEGFQ 383
G + ++C WS AAP C+V C + NG + F A V F CD+GF
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 384 LKGSSASYCVLAGMESLWNSSVPVCERKS 412
L GS C S W+ VP C + S
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVS 287
>gi|27502415 CD46 antigen, complement regulatory protein isoform 9
precursor [Homo sapiens]
Length = 363
Score = 191 bits (484), Expect = 2e-48
Identities = 111/293 (37%), Positives = 148/293 (50%), Gaps = 12/293 (4%)
Query: 1 MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY 60
M PP R E PFPS RFPGLLLAA+VLLL SFSD C P + + IG
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPY-YEIGER 59
Query: 61 LNYECRPGYSGRP---FSIICLKNSVWTSAKDK-CKRKSCRNPPDPVNGMAHVIKDI-QF 115
++Y+C+ GY P IC +N W D C R++C DP+NG A +F
Sbjct: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEF 119
Query: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
Q+ + C +GY LIG C + G+ IW K P+C++++C PP I NG T E
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVE 179
Query: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235
F Y VTY C+ + G F L+GE +IYC +WS AP+C + KC P V
Sbjct: 180 VFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVV 233
Query: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV 288
ENG +S F V F C GF + G + C + + W+P +P C +V
Sbjct: 234 ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
Score = 105 bits (262), Expect = 1e-22
Identities = 61/176 (34%), Positives = 91/176 (51%), Gaps = 6/176 (3%)
Query: 369 QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGM-VHVI 427
++G +VD+ C +G+ A++ + + S C R++C P+NG V
Sbjct: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
Query: 428 TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHT 487
G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG+HT
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT 174
Query: 488 GTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
+ + Y V+Y+CDP P F+LIGESTI N VWS AP C++
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD----NSVWSRAAPECKV 225
Score = 99.4 bits (246), Expect = 8e-21
Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 28/272 (10%)
Query: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--STYLHCTPQGDWS 339
L S S C+ PP E + K + G+ V Y C+ GY +T+ C W
Sbjct: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
Query: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397
P + + ++ NG + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
Query: 398 ESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG---SRINYSCTTG-----HRLIGH 449
++W+ P+CE+ C PP NG H +++ V + YSC LIG
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGE 205
Query: 450 SSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPD 509
S+ C G+ + WS P C+ + C P + NG+ Y V + CD
Sbjct: 206 STIYC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD---- 257
Query: 510 RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
F L G TI S N W P P+C
Sbjct: 258 --KGFYLDGSDTIVCDS----NSTWDPPVPKC 283
Score = 82.4 bits (202), Expect = 1e-15
Identities = 61/233 (26%), Positives = 87/233 (37%), Gaps = 13/233 (5%)
Query: 118 QIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYF 177
++ Y C KGY I + I N C R C NG + Y
Sbjct: 59 RVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTY- 117
Query: 178 HYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVEN 237
+G + + CN G + L+GE +YC K V IWSG P C PP ++N
Sbjct: 118 EFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPPKIKN 170
Query: 238 GILVSDNRSLFSLNEVVEFRCQPG-----FGMKGPSHVKCQALNKWEPELPSCSRVCQPP 292
G +F + V + C P F + G S + C + W P C V
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC 345
P V + ++ F V + C+ G+ L GS + C W P P+C
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 80.5 bits (197), Expect = 4e-15
Identities = 71/269 (26%), Positives = 105/269 (39%), Gaps = 30/269 (11%)
Query: 158 CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217
C PPT + + Y+ G V Y C G F + P + + D+ W
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
Query: 218 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
+ C P + NG V N + + + F C G+ + G + C+
Sbjct: 87 LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
Query: 275 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 325
W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVL--FPLNLQLGAKVDFVCDEGFQ 383
G + ++C WS AAP C+V C + NG + F A V F CD+GF
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 384 LKGSSASYCVLAGMESLWNSSVPVCERKS 412
L GS C S W+ VP C + S
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVS 287
>gi|27502407 CD46 antigen, complement regulatory protein isoform 3
precursor [Homo sapiens]
Length = 377
Score = 191 bits (484), Expect = 2e-48
Identities = 111/293 (37%), Positives = 148/293 (50%), Gaps = 12/293 (4%)
Query: 1 MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY 60
M PP R E PFPS RFPGLLLAA+VLLL SFSD C P + + IG
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPY-YEIGER 59
Query: 61 LNYECRPGYSGRP---FSIICLKNSVWTSAKDK-CKRKSCRNPPDPVNGMAHVIKDI-QF 115
++Y+C+ GY P IC +N W D C R++C DP+NG A +F
Sbjct: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEF 119
Query: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
Q+ + C +GY LIG C + G+ IW K P+C++++C PP I NG T E
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVE 179
Query: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235
F Y VTY C+ + G F L+GE +IYC +WS AP+C + KC P V
Sbjct: 180 VFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVV 233
Query: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV 288
ENG +S F V F C GF + G + C + + W+P +P C +V
Sbjct: 234 ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
Score = 105 bits (262), Expect = 1e-22
Identities = 61/176 (34%), Positives = 91/176 (51%), Gaps = 6/176 (3%)
Query: 369 QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGM-VHVI 427
++G +VD+ C +G+ A++ + + S C R++C P+NG V
Sbjct: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
Query: 428 TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHT 487
G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG+HT
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT 174
Query: 488 GTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
+ + Y V+Y+CDP P F+LIGESTI N VWS AP C++
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD----NSVWSRAAPECKV 225
Score = 99.4 bits (246), Expect = 8e-21
Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 28/272 (10%)
Query: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--STYLHCTPQGDWS 339
L S S C+ PP E + K + G+ V Y C+ GY +T+ C W
Sbjct: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
Query: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397
P + + ++ NG + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
Query: 398 ESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG---SRINYSCTTG-----HRLIGH 449
++W+ P+CE+ C PP NG H +++ V + YSC LIG
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGE 205
Query: 450 SSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPD 509
S+ C G+ + WS P C+ + C P + NG+ Y V + CD
Sbjct: 206 STIYC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD---- 257
Query: 510 RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
F L G TI S N W P P+C
Sbjct: 258 --KGFYLDGSDTIVCDS----NSTWDPPVPKC 283
Score = 82.4 bits (202), Expect = 1e-15
Identities = 61/233 (26%), Positives = 87/233 (37%), Gaps = 13/233 (5%)
Query: 118 QIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYF 177
++ Y C KGY I + I N C R C NG + Y
Sbjct: 59 RVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTY- 117
Query: 178 HYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVEN 237
+G + + CN G + L+GE +YC K V IWSG P C PP ++N
Sbjct: 118 EFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPPKIKN 170
Query: 238 GILVSDNRSLFSLNEVVEFRCQPG-----FGMKGPSHVKCQALNKWEPELPSCSRVCQPP 292
G +F + V + C P F + G S + C + W P C V
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC 345
P V + ++ F V + C+ G+ L GS + C W P P+C
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 80.5 bits (197), Expect = 4e-15
Identities = 71/269 (26%), Positives = 105/269 (39%), Gaps = 30/269 (11%)
Query: 158 CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217
C PPT + + Y+ G V Y C G F + P + + D+ W
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
Query: 218 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
+ C P + NG V N + + + F C G+ + G + C+
Sbjct: 87 LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
Query: 275 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 325
W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVL--FPLNLQLGAKVDFVCDEGFQ 383
G + ++C WS AAP C+V C + NG + F A V F CD+GF
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 384 LKGSSASYCVLAGMESLWNSSVPVCERKS 412
L GS C S W+ VP C + S
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVS 287
>gi|24432108 CD46 antigen, complement regulatory protein isoform 4
precursor [Homo sapiens]
Length = 384
Score = 191 bits (484), Expect = 2e-48
Identities = 111/293 (37%), Positives = 148/293 (50%), Gaps = 12/293 (4%)
Query: 1 MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY 60
M PP R E PFPS RFPGLLLAA+VLLL SFSD C P + + IG
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPY-YEIGER 59
Query: 61 LNYECRPGYSGRP---FSIICLKNSVWTSAKDK-CKRKSCRNPPDPVNGMAHVIKDI-QF 115
++Y+C+ GY P IC +N W D C R++C DP+NG A +F
Sbjct: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEF 119
Query: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
Q+ + C +GY LIG C + G+ IW K P+C++++C PP I NG T E
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVE 179
Query: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235
F Y VTY C+ + G F L+GE +IYC +WS AP+C + KC P V
Sbjct: 180 VFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVV 233
Query: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV 288
ENG +S F V F C GF + G + C + + W+P +P C +V
Sbjct: 234 ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKV 286
Score = 105 bits (262), Expect = 1e-22
Identities = 61/176 (34%), Positives = 91/176 (51%), Gaps = 6/176 (3%)
Query: 369 QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGM-VHVI 427
++G +VD+ C +G+ A++ + + S C R++C P+NG V
Sbjct: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
Query: 428 TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHT 487
G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG+HT
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT 174
Query: 488 GTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
+ + Y V+Y+CDP P F+LIGESTI N VWS AP C++
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD----NSVWSRAAPECKV 225
Score = 99.4 bits (246), Expect = 8e-21
Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 28/272 (10%)
Query: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--STYLHCTPQGDWS 339
L S S C+ PP E + K + G+ V Y C+ GY +T+ C W
Sbjct: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
Query: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397
P + + ++ NG + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
Query: 398 ESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG---SRINYSCTTG-----HRLIGH 449
++W+ P+CE+ C PP NG H +++ V + YSC LIG
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGE 205
Query: 450 SSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPD 509
S+ C G+ + WS P C+ + C P + NG+ Y V + CD
Sbjct: 206 STIYC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD---- 257
Query: 510 RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
F L G TI S N W P P+C
Sbjct: 258 --KGFYLDGSDTIVCDS----NSTWDPPVPKC 283
Score = 82.4 bits (202), Expect = 1e-15
Identities = 61/233 (26%), Positives = 87/233 (37%), Gaps = 13/233 (5%)
Query: 118 QIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYF 177
++ Y C KGY I + I N C R C NG + Y
Sbjct: 59 RVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTY- 117
Query: 178 HYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVEN 237
+G + + CN G + L+GE +YC K V IWSG P C PP ++N
Sbjct: 118 EFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPPKIKN 170
Query: 238 GILVSDNRSLFSLNEVVEFRCQPG-----FGMKGPSHVKCQALNKWEPELPSCSRVCQPP 292
G +F + V + C P F + G S + C + W P C V
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC 345
P V + ++ F V + C+ G+ L GS + C W P P+C
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 80.5 bits (197), Expect = 4e-15
Identities = 71/269 (26%), Positives = 105/269 (39%), Gaps = 30/269 (11%)
Query: 158 CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217
C PPT + + Y+ G V Y C G F + P + + D+ W
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
Query: 218 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
+ C P + NG V N + + + F C G+ + G + C+
Sbjct: 87 LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
Query: 275 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 325
W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVL--FPLNLQLGAKVDFVCDEGFQ 383
G + ++C WS AAP C+V C + NG + F A V F CD+GF
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 384 LKGSSASYCVLAGMESLWNSSVPVCERKS 412
L GS C S W+ VP C + S
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKVS 287
>gi|27502411 CD46 antigen, complement regulatory protein isoform 6
precursor [Homo sapiens]
Length = 369
Score = 190 bits (482), Expect = 3e-48
Identities = 111/296 (37%), Positives = 149/296 (50%), Gaps = 12/296 (4%)
Query: 1 MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY 60
M PP R E PFPS RFPGLLLAA+VLLL SFSD C P + + IG
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPY-YEIGER 59
Query: 61 LNYECRPGYSGRP---FSIICLKNSVWTSAKDK-CKRKSCRNPPDPVNGMAHVIKDI-QF 115
++Y+C+ GY P IC +N W D C R++C DP+NG A +F
Sbjct: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEF 119
Query: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
Q+ + C +GY LIG C + G+ IW K P+C++++C PP I NG T E
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVE 179
Query: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235
F Y VTY C+ + G F L+GE +IYC +WS AP+C + KC P V
Sbjct: 180 VFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVV 233
Query: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQP 291
ENG +S F V F C GF + G + C + + W+P +P C + +P
Sbjct: 234 ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRP 289
Score = 105 bits (262), Expect = 1e-22
Identities = 61/176 (34%), Positives = 91/176 (51%), Gaps = 6/176 (3%)
Query: 369 QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGM-VHVI 427
++G +VD+ C +G+ A++ + + S C R++C P+NG V
Sbjct: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
Query: 428 TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHT 487
G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG+HT
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT 174
Query: 488 GTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
+ + Y V+Y+CDP P F+LIGESTI N VWS AP C++
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD----NSVWSRAAPECKV 225
Score = 99.4 bits (246), Expect = 8e-21
Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 28/272 (10%)
Query: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--STYLHCTPQGDWS 339
L S S C+ PP E + K + G+ V Y C+ GY +T+ C W
Sbjct: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
Query: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397
P + + ++ NG + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
Query: 398 ESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG---SRINYSCTTG-----HRLIGH 449
++W+ P+CE+ C PP NG H +++ V + YSC LIG
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGE 205
Query: 450 SSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPD 509
S+ C G+ + WS P C+ + C P + NG+ Y V + CD
Sbjct: 206 STIYC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD---- 257
Query: 510 RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
F L G TI S N W P P+C
Sbjct: 258 --KGFYLDGSDTIVCDS----NSTWDPPVPKC 283
Score = 82.4 bits (202), Expect = 1e-15
Identities = 61/233 (26%), Positives = 87/233 (37%), Gaps = 13/233 (5%)
Query: 118 QIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYF 177
++ Y C KGY I + I N C R C NG + Y
Sbjct: 59 RVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTY- 117
Query: 178 HYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVEN 237
+G + + CN G + L+GE +YC K V IWSG P C PP ++N
Sbjct: 118 EFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPPKIKN 170
Query: 238 GILVSDNRSLFSLNEVVEFRCQPG-----FGMKGPSHVKCQALNKWEPELPSCSRVCQPP 292
G +F + V + C P F + G S + C + W P C V
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC 345
P V + ++ F V + C+ G+ L GS + C W P P+C
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 81.3 bits (199), Expect = 2e-15
Identities = 73/278 (26%), Positives = 108/278 (38%), Gaps = 30/278 (10%)
Query: 158 CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217
C PPT + + Y+ G V Y C G F + P + + D+ W
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
Query: 218 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
+ C P + NG V N + + + F C G+ + G + C+
Sbjct: 87 LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
Query: 275 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 325
W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVL--FPLNLQLGAKVDFVCDEGFQ 383
G + ++C WS AAP C+V C + NG + F A V F CD+GF
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 384 LKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVN 421
L GS C S W+ VP C + T PV+
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKGPRPTYKPPVS 296
>gi|27502409 CD46 antigen, complement regulatory protein isoform 5
precursor [Homo sapiens]
Length = 362
Score = 190 bits (482), Expect = 3e-48
Identities = 111/296 (37%), Positives = 149/296 (50%), Gaps = 12/296 (4%)
Query: 1 MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY 60
M PP R E PFPS RFPGLLLAA+VLLL SFSD C P + + IG
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPY-YEIGER 59
Query: 61 LNYECRPGYSGRP---FSIICLKNSVWTSAKDK-CKRKSCRNPPDPVNGMAHVIKDI-QF 115
++Y+C+ GY P IC +N W D C R++C DP+NG A +F
Sbjct: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEF 119
Query: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
Q+ + C +GY LIG C + G+ IW K P+C++++C PP I NG T E
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVE 179
Query: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235
F Y VTY C+ + G F L+GE +IYC +WS AP+C + KC P V
Sbjct: 180 VFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVV 233
Query: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQP 291
ENG +S F V F C GF + G + C + + W+P +P C + +P
Sbjct: 234 ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRP 289
Score = 105 bits (262), Expect = 1e-22
Identities = 61/176 (34%), Positives = 91/176 (51%), Gaps = 6/176 (3%)
Query: 369 QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGM-VHVI 427
++G +VD+ C +G+ A++ + + S C R++C P+NG V
Sbjct: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
Query: 428 TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHT 487
G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG+HT
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT 174
Query: 488 GTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
+ + Y V+Y+CDP P F+LIGESTI N VWS AP C++
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD----NSVWSRAAPECKV 225
Score = 99.4 bits (246), Expect = 8e-21
Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 28/272 (10%)
Query: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--STYLHCTPQGDWS 339
L S S C+ PP E + K + G+ V Y C+ GY +T+ C W
Sbjct: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
Query: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397
P + + ++ NG + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
Query: 398 ESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG---SRINYSCTTG-----HRLIGH 449
++W+ P+CE+ C PP NG H +++ V + YSC LIG
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGE 205
Query: 450 SSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPD 509
S+ C G+ + WS P C+ + C P + NG+ Y V + CD
Sbjct: 206 STIYC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD---- 257
Query: 510 RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
F L G TI S N W P P+C
Sbjct: 258 --KGFYLDGSDTIVCDS----NSTWDPPVPKC 283
Score = 82.4 bits (202), Expect = 1e-15
Identities = 61/233 (26%), Positives = 87/233 (37%), Gaps = 13/233 (5%)
Query: 118 QIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYF 177
++ Y C KGY I + I N C R C NG + Y
Sbjct: 59 RVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTY- 117
Query: 178 HYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVEN 237
+G + + CN G + L+GE +YC K V IWSG P C PP ++N
Sbjct: 118 EFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPPKIKN 170
Query: 238 GILVSDNRSLFSLNEVVEFRCQPG-----FGMKGPSHVKCQALNKWEPELPSCSRVCQPP 292
G +F + V + C P F + G S + C + W P C V
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC 345
P V + ++ F V + C+ G+ L GS + C W P P+C
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 81.3 bits (199), Expect = 2e-15
Identities = 73/278 (26%), Positives = 108/278 (38%), Gaps = 30/278 (10%)
Query: 158 CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217
C PPT + + Y+ G V Y C G F + P + + D+ W
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
Query: 218 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
+ C P + NG V N + + + F C G+ + G + C+
Sbjct: 87 LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
Query: 275 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 325
W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVL--FPLNLQLGAKVDFVCDEGFQ 383
G + ++C WS AAP C+V C + NG + F A V F CD+GF
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 384 LKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVN 421
L GS C S W+ VP C + T PV+
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKGPRPTYKPPVS 296
>gi|27502405 CD46 antigen, complement regulatory protein isoform 14
precursor [Homo sapiens]
Length = 349
Score = 190 bits (482), Expect = 3e-48
Identities = 111/296 (37%), Positives = 149/296 (50%), Gaps = 12/296 (4%)
Query: 1 MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY 60
M PP R E PFPS RFPGLLLAA+VLLL SFSD C P + + IG
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPY-YEIGER 59
Query: 61 LNYECRPGYSGRP---FSIICLKNSVWTSAKDK-CKRKSCRNPPDPVNGMAHVIKDI-QF 115
++Y+C+ GY P IC +N W D C R++C DP+NG A +F
Sbjct: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEF 119
Query: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
Q+ + C +GY LIG C + G+ IW K P+C++++C PP I NG T E
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVE 179
Query: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235
F Y VTY C+ + G F L+GE +IYC +WS AP+C + KC P V
Sbjct: 180 VFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVV 233
Query: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQP 291
ENG +S F V F C GF + G + C + + W+P +P C + +P
Sbjct: 234 ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRP 289
Score = 105 bits (262), Expect = 1e-22
Identities = 61/176 (34%), Positives = 91/176 (51%), Gaps = 6/176 (3%)
Query: 369 QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGM-VHVI 427
++G +VD+ C +G+ A++ + + S C R++C P+NG V
Sbjct: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
Query: 428 TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHT 487
G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG+HT
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT 174
Query: 488 GTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
+ + Y V+Y+CDP P F+LIGESTI N VWS AP C++
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD----NSVWSRAAPECKV 225
Score = 99.4 bits (246), Expect = 8e-21
Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 28/272 (10%)
Query: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--STYLHCTPQGDWS 339
L S S C+ PP E + K + G+ V Y C+ GY +T+ C W
Sbjct: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
Query: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397
P + + ++ NG + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
Query: 398 ESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG---SRINYSCTTG-----HRLIGH 449
++W+ P+CE+ C PP NG H +++ V + YSC LIG
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGE 205
Query: 450 SSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPD 509
S+ C G+ + WS P C+ + C P + NG+ Y V + CD
Sbjct: 206 STIYC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD---- 257
Query: 510 RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
F L G TI S N W P P+C
Sbjct: 258 --KGFYLDGSDTIVCDS----NSTWDPPVPKC 283
Score = 82.4 bits (202), Expect = 1e-15
Identities = 61/233 (26%), Positives = 87/233 (37%), Gaps = 13/233 (5%)
Query: 118 QIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYF 177
++ Y C KGY I + I N C R C NG + Y
Sbjct: 59 RVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTY- 117
Query: 178 HYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVEN 237
+G + + CN G + L+GE +YC K V IWSG P C PP ++N
Sbjct: 118 EFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPPKIKN 170
Query: 238 GILVSDNRSLFSLNEVVEFRCQPG-----FGMKGPSHVKCQALNKWEPELPSCSRVCQPP 292
G +F + V + C P F + G S + C + W P C V
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC 345
P V + ++ F V + C+ G+ L GS + C W P P+C
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 81.3 bits (199), Expect = 2e-15
Identities = 73/278 (26%), Positives = 108/278 (38%), Gaps = 30/278 (10%)
Query: 158 CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217
C PPT + + Y+ G V Y C G F + P + + D+ W
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
Query: 218 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
+ C P + NG V N + + + F C G+ + G + C+
Sbjct: 87 LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
Query: 275 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 325
W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVL--FPLNLQLGAKVDFVCDEGFQ 383
G + ++C WS AAP C+V C + NG + F A V F CD+GF
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 384 LKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVN 421
L GS C S W+ VP C + T PV+
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKCLKGPRPTYKPPVS 296
>gi|27502419 CD46 antigen, complement regulatory protein isoform 11
precursor [Homo sapiens]
Length = 348
Score = 189 bits (481), Expect = 4e-48
Identities = 111/299 (37%), Positives = 149/299 (49%), Gaps = 12/299 (4%)
Query: 1 MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY 60
M PP R E PFPS RFPGLLLAA+VLLL SFSD C P + + IG
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPY-YEIGER 59
Query: 61 LNYECRPGYSGRP---FSIICLKNSVWTSAKDK-CKRKSCRNPPDPVNGMAHVIKDI-QF 115
++Y+C+ GY P IC +N W D C R++C DP+NG A +F
Sbjct: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEF 119
Query: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
Q+ + C +GY LIG C + G+ IW K P+C++++C PP I NG T E
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVE 179
Query: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235
F Y VTY C+ + G F L+GE +IYC +WS AP+C + KC P V
Sbjct: 180 VFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVV 233
Query: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPD 294
ENG +S F V F C GF + G + C + + W+P +P C + P +
Sbjct: 234 ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGYPKPEE 292
Score = 105 bits (262), Expect = 1e-22
Identities = 61/176 (34%), Positives = 91/176 (51%), Gaps = 6/176 (3%)
Query: 369 QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGM-VHVI 427
++G +VD+ C +G+ A++ + + S C R++C P+NG V
Sbjct: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
Query: 428 TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHT 487
G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG+HT
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT 174
Query: 488 GTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
+ + Y V+Y+CDP P F+LIGESTI N VWS AP C++
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD----NSVWSRAAPECKV 225
Score = 99.4 bits (246), Expect = 8e-21
Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 28/272 (10%)
Query: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--STYLHCTPQGDWS 339
L S S C+ PP E + K + G+ V Y C+ GY +T+ C W
Sbjct: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
Query: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397
P + + ++ NG + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
Query: 398 ESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG---SRINYSCTTG-----HRLIGH 449
++W+ P+CE+ C PP NG H +++ V + YSC LIG
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGE 205
Query: 450 SSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPD 509
S+ C G+ + WS P C+ + C P + NG+ Y V + CD
Sbjct: 206 STIYC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD---- 257
Query: 510 RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
F L G TI S N W P P+C
Sbjct: 258 --KGFYLDGSDTIVCDS----NSTWDPPVPKC 283
Score = 82.4 bits (202), Expect = 1e-15
Identities = 61/233 (26%), Positives = 87/233 (37%), Gaps = 13/233 (5%)
Query: 118 QIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYF 177
++ Y C KGY I + I N C R C NG + Y
Sbjct: 59 RVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTY- 117
Query: 178 HYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVEN 237
+G + + CN G + L+GE +YC K V IWSG P C PP ++N
Sbjct: 118 EFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPPKIKN 170
Query: 238 GILVSDNRSLFSLNEVVEFRCQPG-----FGMKGPSHVKCQALNKWEPELPSCSRVCQPP 292
G +F + V + C P F + G S + C + W P C V
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC 345
P V + ++ F V + C+ G+ L GS + C W P P+C
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 80.1 bits (196), Expect = 5e-15
Identities = 70/265 (26%), Positives = 103/265 (38%), Gaps = 30/265 (11%)
Query: 158 CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217
C PPT + + Y+ G V Y C G F + P + + D+ W
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
Query: 218 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
+ C P + NG V N + + + F C G+ + G + C+
Sbjct: 87 LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
Query: 275 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 325
W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVL--FPLNLQLGAKVDFVCDEGFQ 383
G + ++C WS AAP C+V C + NG + F A V F CD+GF
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 384 LKGSSASYCVLAGMESLWNSSVPVC 408
L GS C S W+ VP C
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKC 283
>gi|27502427 CD46 antigen, complement regulatory protein isoform 12
precursor [Homo sapiens]
Length = 355
Score = 189 bits (481), Expect = 4e-48
Identities = 111/299 (37%), Positives = 149/299 (49%), Gaps = 12/299 (4%)
Query: 1 MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY 60
M PP R E PFPS RFPGLLLAA+VLLL SFSD C P + + IG
Sbjct: 1 MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPY-YEIGER 59
Query: 61 LNYECRPGYSGRP---FSIICLKNSVWTSAKDK-CKRKSCRNPPDPVNGMAHVIKDI-QF 115
++Y+C+ GY P IC +N W D C R++C DP+NG A +F
Sbjct: 60 VDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEF 119
Query: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
Q+ + C +GY LIG C + G+ IW K P+C++++C PP I NG T E
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVE 179
Query: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV 235
F Y VTY C+ + G F L+GE +IYC +WS AP+C + KC P V
Sbjct: 180 VFEYLDAVTYSCD-PAPGPDPFSLIGESTIYCGDN----SVWSRAAPECKVV-KCRFPVV 233
Query: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPD 294
ENG +S F V F C GF + G + C + + W+P +P C + P +
Sbjct: 234 ENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGYPKPEE 292
Score = 105 bits (262), Expect = 1e-22
Identities = 61/176 (34%), Positives = 91/176 (51%), Gaps = 6/176 (3%)
Query: 369 QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGM-VHVI 427
++G +VD+ C +G+ A++ + + S C R++C P+NG V
Sbjct: 55 EIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN 114
Query: 428 TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHT 487
G ++++ C G+ LIG C L G+ A WS KPPIC+++ C PP I NG+HT
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT 174
Query: 488 GTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
+ + Y V+Y+CDP P F+LIGESTI N VWS AP C++
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPD-PFSLIGESTIYCGD----NSVWSRAAPECKV 225
Score = 99.4 bits (246), Expect = 8e-21
Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 28/272 (10%)
Query: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG--STYLHCTPQGDWS 339
L S S C+ PP E + K + G+ V Y C+ GY +T+ C W
Sbjct: 28 LYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWL 87
Query: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLN--LQLGAKVDFVCDEGFQLKGSSASYCVLAGM 397
P + + ++ NG + P N + G ++ F+C+EG+ L G YC L G
Sbjct: 88 PVSDDACYRETCPYIRDPLNGQAV-PANGTYEFGYQMHFICNEGYYLIGEEILYCELKGS 146
Query: 398 ESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVG---SRINYSCTTG-----HRLIGH 449
++W+ P+CE+ C PP NG H +++ V + YSC LIG
Sbjct: 147 VAIWSGKPPICEKVLCTPPPKIKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGE 205
Query: 450 SSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPD 509
S+ C G+ + WS P C+ + C P + NG+ Y V + CD
Sbjct: 206 STIYC---GDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECD---- 257
Query: 510 RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
F L G TI S N W P P+C
Sbjct: 258 --KGFYLDGSDTIVCDS----NSTWDPPVPKC 283
Score = 82.4 bits (202), Expect = 1e-15
Identities = 61/233 (26%), Positives = 87/233 (37%), Gaps = 13/233 (5%)
Query: 118 QIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYF 177
++ Y C KGY I + I N C R C NG + Y
Sbjct: 59 RVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTY- 117
Query: 178 HYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVEN 237
+G + + CN G + L+GE +YC K V IWSG P C PP ++N
Sbjct: 118 EFGYQMHFICNEG------YYLIGEEILYCELKGS-VAIWSGKPPICEKVLCTPPPKIKN 170
Query: 238 GILVSDNRSLFSLNEVVEFRCQPG-----FGMKGPSHVKCQALNKWEPELPSCSRVCQPP 292
G +F + V + C P F + G S + C + W P C V
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC 345
P V + ++ F V + C+ G+ L GS + C W P P+C
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 80.1 bits (196), Expect = 5e-15
Identities = 70/265 (26%), Positives = 103/265 (38%), Gaps = 30/265 (11%)
Query: 158 CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217
C PPT + + Y+ G V Y C G F + P + + D+ W
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKG-----YFYI---PPLATHTICDRNHTW 86
Query: 218 SGPAPQCIIPNKCTPPNVE---NGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
+ C P + NG V N + + + F C G+ + G + C+
Sbjct: 87 LPVSDDACYRETC--PYIRDPLNGQAVPANGT-YEFGYQMHFICNEGYYLIGEEILYCEL 143
Query: 275 LNK---WEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-----YDLR 325
W + P C +V C PPP + + + T + + F V YSC+P + L
Sbjct: 144 KGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVL--FPLNLQLGAKVDFVCDEGFQ 383
G + ++C WS AAP C+V C + NG + F A V F CD+GF
Sbjct: 204 GESTIYCGDNSVWSRAAPECKVVKCR--FPVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 384 LKGSSASYCVLAGMESLWNSSVPVC 408
L GS C S W+ VP C
Sbjct: 262 LDGSDTIVC---DSNSTWDPPVPKC 283
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 182 bits (462), Expect = 7e-46
Identities = 143/492 (29%), Positives = 204/492 (41%), Gaps = 52/492 (10%)
Query: 65 CRPGYSGRPFSII-CLKNSVWT--SAKDKCKRKSCRNPPDPVNGMAHVIKDIQ-FRSQIK 120
C PGY +I C N W+ + C+ SC P P NG H I + + +
Sbjct: 2624 CDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNG--HRIGTLSVYGATAI 2681
Query: 121 YSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYG 180
+SC GY L+GS C+ +G +W C CG P I NG I+ E + Y
Sbjct: 2682 FSCNSGYTLVGSRVRECMANG---LWSGSEVRCLAGHCGTPEPIVNGH---INGENYSYR 2735
Query: 181 SVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGIL 240
V Y CN G F L+G C Q WSG P C++ + P + + +
Sbjct: 2736 GSVVYQCNAG------FRLIGMSVRIC----QQDHHWSGKTPFCVLVSCGHPGSPPHSQM 2785
Query: 241 VSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSR----VCQPPPDVL 296
D+ +++ VV + C + G S C W LP CS VC P
Sbjct: 2786 SGDS---YTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPA 2842
Query: 297 HAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQ 356
H R D+F PG + +SCE G+ LRGS+ C G WS + P C V SC + G
Sbjct: 2843 HGIRLG---DSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGN-PGT 2898
Query: 357 LPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETP 416
N V+F L + + + C EG+ G + +C + G W S P C +C P
Sbjct: 2899 PSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNG---TWTGSDPECLVINCGDP 2955
Query: 417 PVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCP 476
+P NG+ + D + Y C G+ + H + W+ P+C+ + C
Sbjct: 2956 GIPANGL-RLGNDFRYNKTVTYQCVPGYMMESH-RVSVLSCTKDRTWNGTKPVCKALMCK 3013
Query: 477 NPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSS 536
PP I NG+ G+ D +G V+Y C G +L T GNG W+
Sbjct: 3014 PPPLIPNGKVVGS---DFMWGSSVTYAC----LEGYQLSLPAVFTC------EGNGSWTG 3060
Query: 537 PAPRCELPVGAG 548
P+C PV G
Sbjct: 3061 ELPQC-FPVFCG 3071
Score = 167 bits (424), Expect = 2e-41
Identities = 132/484 (27%), Positives = 205/484 (42%), Gaps = 47/484 (9%)
Query: 63 YECRPGYSGRPFSII-CLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKY 121
+ C GY+ + C+ N +W+ ++ +C C P VNG + ++ +R + Y
Sbjct: 2682 FSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHING-ENYSYRGSVVY 2740
Query: 122 SCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGS 181
C G+RLIG S C + W KTP C + CG P + + +S + + G+
Sbjct: 2741 QCNAGFRLIGMSVRICQQDHH---WSGKTPFCVLVSCGHP---GSPPHSQMSGDSYTVGA 2794
Query: 182 VVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQC--IIPNKCTPPNVE-NG 238
VV Y C +G R LVG + C G W+G P C C P + +G
Sbjct: 2795 VVRYSC-IGKR-----TLVGNSTRMCGLD----GHWTGSLPHCSGTSVGVCGDPGIPAHG 2844
Query: 239 ILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV-CQPPPDVLH 297
I + D+ F V+ F C+ G ++G S CQA W P C + C P +
Sbjct: 2845 IRLGDS---FDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSN 2901
Query: 298 AERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQL 357
A D FS + Y C GY G HC+ G W+ + P C V +C D +
Sbjct: 2902 ARVVFSDGLVFS--SSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGD--PGI 2957
Query: 358 PNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPP 417
P + + + V + C G+ ++ S + + WN + PVC+ C+ PP
Sbjct: 2958 PANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSV-LSCTKDRTWNGTKPVCKALMCKPPP 3016
Query: 418 VPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPN 477
+ NG V V +D GS + Y+C G++L + C +G+ W+ + P C +FC +
Sbjct: 3017 LIPNGKV-VGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGS---WTGELPQCFPVFCGD 3072
Query: 478 PPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSP 537
P GR Y VS++C P L+ + RR + +G WS
Sbjct: 3073 PGVPSRGRREDR---GFSYRSSVSFSCHP--------PLVLVGSPRRFCQ--SDGTWSGT 3119
Query: 538 APRC 541
P C
Sbjct: 3120 QPSC 3123
Score = 156 bits (395), Expect = 4e-38
Identities = 125/424 (29%), Positives = 172/424 (40%), Gaps = 31/424 (7%)
Query: 55 FPIGTYLNYECRPGYSGRPFSI-ICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDI 113
F GT + + C G+ R S C N W+ ++ +C SC NP P N +
Sbjct: 2851 FDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGL 2910
Query: 114 QFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSIS 173
F S I Y C +GY G S C ++G W P C I CG P ANG +
Sbjct: 2911 VFSSSIVYECREGYYATGLLSRHCSVNGT---WTGSDPECLVINCGDPGIPANG--LRLG 2965
Query: 174 REYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPP 233
+ F Y VTY C G + S+ +KD W+G P C PP
Sbjct: 2966 ND-FRYNKTVTYQCVPGYMMES-----HRVSVLSCTKDRT---WNGTKPVCKALMCKPPP 3016
Query: 234 NVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPP 293
+ NG +V + F V + C G+ + P+ C+ W ELP C V P
Sbjct: 3017 LIPNGKVVGSD---FMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDP 3073
Query: 294 DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC---EVKSC 350
V R +R+ FS V +SC P L GS C G WS P C + +C
Sbjct: 3074 GV--PSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTC 3131
Query: 351 DDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCER 410
D G G Q+G+ V F C +G+ L+GS+ C+ W+ + P C
Sbjct: 3132 AD-PGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCL---PNLTWSGTPPDCVP 3187
Query: 411 KSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSS-AECILSGNTAHWSMKPPI 469
C P P + V + +G + YSC G L G S C G+ W+ KPPI
Sbjct: 3188 HHCRQPETPTHANVGALDLPSMGYTLIYSCQEGFSLKGGSEHRTCKADGS---WTGKPPI 3244
Query: 470 CQQI 473
C ++
Sbjct: 3245 CLEV 3248
Score = 155 bits (391), Expect = 1e-37
Identities = 135/479 (28%), Positives = 193/479 (40%), Gaps = 44/479 (9%)
Query: 41 LPFARPTNLTDDFEFPIGTYLNYECRPGY---SGRPFSIICLKNSVWT--SAKDKCKRKS 95
LP A + E+ +GT Y C GY +G + CL +W+ + +C +
Sbjct: 2533 LPEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVT 2592
Query: 96 CRNPP--DPVNGMAHVI--KDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTP 151
C + +G +I QF++Q+ C GY G C +G + D+ TP
Sbjct: 2593 CPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDS-TP 2651
Query: 152 VCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKD 211
C I CG P NG YG+ + CN G + LVG C +
Sbjct: 2652 TCRIISCGELPIPPNGHRIGTLSV---YGATAIFSCNSG------YTLVGSRVRECMAN- 2701
Query: 212 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVK 271
G+WSG +C+ + TP + NG + +N +S V ++C GF + G S
Sbjct: 2702 ---GLWSGSEVRCLAGHCGTPEPIVNGHINGEN---YSYRGSVVYQCNAGFRLIGMSVRI 2755
Query: 272 CQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYL 330
CQ + W + P C V C P H +Q D+++ G V YSC L G++
Sbjct: 2756 CQQDHHWSGKTPFCVLVSCGHPGSPPH---SQMSGDSYTVGAVVRYSCIGKRTLVGNSTR 2812
Query: 331 HCTPQGDWSPAAPRC---EVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGS 387
C G W+ + P C V C D +P + + G + F C+ G L+GS
Sbjct: 2813 MCGLDGHWTGSLPHCSGTSVGVCGD--PGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGS 2870
Query: 388 SASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLI 447
S C G W+ S P C SC P P N V + S I Y C G+
Sbjct: 2871 SERTCQANGS---WSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYAT 2927
Query: 448 GHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDP 506
G S C ++G W+ P C I C +P NG G D Y K V+Y C P
Sbjct: 2928 GLLSRHCSVNGT---WTGSDPECLVINCGDPGIPANGLRLG---NDFRYNKTVTYQCVP 2980
Score = 126 bits (317), Expect = 5e-29
Identities = 134/516 (25%), Positives = 187/516 (36%), Gaps = 68/516 (13%)
Query: 53 FEFPIGTYLNYECRPGYSGRPFSIICLKNSV---WTSA--------KDKCKRKSCRNPPD 101
F+ P G + G P + NSV W+S K + C P
Sbjct: 2414 FDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYCSLPRA 2473
Query: 102 PVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTV-IWDNKTPVCDRIICGL 160
P++G Q I + C GYRL+G S A C +W P+C + CGL
Sbjct: 2474 PLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGL 2533
Query: 161 PPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWS-- 218
P NG + + + G+ Y C+ G + E + C G+WS
Sbjct: 2534 PEAPKNG---MVFGKEYTVGTKAMYSCSEGYH----LQAGAEATAECL----DTGLWSNR 2582
Query: 219 GPAPQCIIPNKC---TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQAL 275
PQC +P C + +VE+G + + + C PG+ G ++CQA
Sbjct: 2583 NVPPQC-VPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQAN 2641
Query: 276 NKWE--PELPSCSRVC---QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYL 330
KW P+C + P P H T G +SC GY L GS
Sbjct: 2642 GKWSLGDSTPTCRIISCGELPIPPNGHRIGTLS-----VYGATAIFSCNSGYTLVGSRVR 2696
Query: 331 HCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSAS 390
C G WS + RC C + NGH+ N V + C+ GF+L G S
Sbjct: 2697 ECMANGLWSGSEVRCLAGHCGT-PEPIVNGHINGE-NYSYRGSVVYQCNAGFRLIGMSVR 2754
Query: 391 YCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHS 450
C + W+ P C SC P P + + VG+ + YSC L+G+S
Sbjct: 2755 IC---QQDHHWSGKTPFCVLVSCGHPGSPPHSQMSG-DSYTVGAVVRYSCIGKRTLVGNS 2810
Query: 451 SAECILSGNTAHWSMKPPICQQI---FCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPH 507
+ C L G HW+ P C C +P G P I G
Sbjct: 2811 TRMCGLDG---HWTGSLPHCSGTSVGVCGDP---------GIPAHGIRLGDSFD------ 2852
Query: 508 PDRGMTFNLIGESTIRRTSEP--HGNGVWSSPAPRC 541
P M F+ +R +SE NG WS P C
Sbjct: 2853 PGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPEC 2888
Score = 88.6 bits (218), Expect = 1e-17
Identities = 134/582 (23%), Positives = 211/582 (36%), Gaps = 150/582 (25%)
Query: 91 CKRKSCRNPPDPVNGMAHVIKDIQFR--SQIKYSCPKGYRLIGSSSATCIISGNTVIWDN 148
C+ + PDP +++ + + + C GY+L G TC G WD+
Sbjct: 2115 CEAYELQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQ-HGTNRNWDH 2173
Query: 149 KTPVCDRIICGLPPTIANGDFTSISREYFHYGS-----VVTYHCNLGSRGKKVFELVGEP 203
P C+ + CG T +NG S + S ++T G R + L EP
Sbjct: 2174 PLPKCE-VPCGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVR-LNLSLLQTEP 2231
Query: 204 SIYCTSKDDQVGIWSGP---APQCII---------------------------------- 226
S D + IW GP AP+ +
Sbjct: 2232 S------GDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGIFAIA 2285
Query: 227 -----PNKCTPPNV-ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQ--ALNKW 278
KC PP + N +V++N F++ ++V +RC PGF + G + C+ ++
Sbjct: 2286 FSAYPLTKCPPPTILPNAEVVTENEE-FNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQF 2344
Query: 279 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQ-EVFYSC------EPGYDL------- 324
E P C C P + L + T PG F +C EP Y++
Sbjct: 2345 EGPPPICEVHC--PTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYF 2402
Query: 325 ---------------RGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGH-------- 361
G + L G++S AP S + + + H
Sbjct: 2403 LSEKQYDEFEIFDGPSGQSPLLKALSGNYS--APLIVTSSSNSVYLRWSSDHAYNRKGFK 2460
Query: 362 ------------------VLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM-ESLWN 402
+L + Q G + F C+ G++L G S + C LW+
Sbjct: 2461 IRYSAPYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWS 2520
Query: 403 SSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLI--GHSSAECILSGNT 460
++P+C+ SC P P NGMV + VG++ YSC+ G+ L ++AEC+ +T
Sbjct: 2521 EAIPLCQALSCGLPEAPKNGMVFG-KEYTVGTKAMYSCSEGYHLQAGAEATAECL---DT 2576
Query: 461 AHWSMK--PPICQQIFCPNPPAIL--NGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNL 516
WS + PP C + CP+ +I +GR + ++ CDP +
Sbjct: 2577 GLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDP------GYYY 2630
Query: 517 IGESTIRRTSEPHGNGVWS--SPAPRC------ELPVGAGSH 550
G+ IR NG WS P C ELP+ H
Sbjct: 2631 TGQRVIR----CQANGKWSLGDSTPTCRIISCGELPIPPNGH 2668
Score = 72.4 bits (176), Expect = 1e-12
Identities = 98/437 (22%), Positives = 165/437 (37%), Gaps = 86/437 (19%)
Query: 93 RKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIIS-GNTVIWDNKTP 151
R+SC +P NG V D++ S + Y C GY + G+S+ +CI+ +W+N P
Sbjct: 1555 RESCFDPGSIKNG-TRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRP 1613
Query: 152 VCDRIICGLPPTIANGDFTSISREY---FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCT 208
VC CG D +S Y + G + Y + K + + G+ + + T
Sbjct: 1614 VC-TAPCG--GQYVGSDGVVLSPNYPQNYTSGQICLYFVTV----PKDYVVFGQFAFFHT 1666
Query: 209 SKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPS 268
+ +D V + G + + + +G ++ L + N+V+ G
Sbjct: 1667 ALNDVVEVHDGHSQHSRLLSSL------SGSHTGESLPLATSNQVLIKFSAKGLAPARGF 1720
Query: 269 HVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGST 328
H QA+ + + + C P+ + +R D FS G V + C GY L+GS
Sbjct: 1721 HFVYQAVPR------TSATQCSSVPEPRYGKRLGSD---FSVGAIVRFECNSGYALQGSP 1771
Query: 329 YLHCTP----QGDWSPAAPRCEVKSCDDFLGQLPNGHVLFP------LNLQLGAKVDFVC 378
+ C P W+ +AP C V C L + G +L P LN L V
Sbjct: 1772 EIECLPVPGALAQWNVSAPTC-VVPCGGNLTE-RRGTILSPGFPEPYLN-SLNCVWKIVV 1828
Query: 379 DEGFQLKGSSASYCVLAGMESL-----WNSSVPVCERKSCETPPVPVNG-----MVHVIT 428
EG ++ S+ +SL +++V + S T P +N +H +
Sbjct: 1829 PEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYS 1888
Query: 429 DIHVGSR-----------------------------------INYSCTTGHRLIGHSSAE 453
DI V + +++ C G+ L GH+
Sbjct: 1889 DISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHIS 1948
Query: 454 CILSGNTAHWSMKPPIC 470
C + G W+ PP+C
Sbjct: 1949 C-MPGTVRRWNYPPPLC 1964
Score = 67.4 bits (163), Expect = 3e-11
Identities = 100/457 (21%), Positives = 165/457 (36%), Gaps = 53/457 (11%)
Query: 96 CRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDR 155
C +P P G + S + +SC GY L GS C+ SG WD P C
Sbjct: 1211 CEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCL-SGERRTWDRPLPTCVA 1269
Query: 156 IICGLPPTIANGDFTS--ISREYFH-YGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDD 212
G +G S Y H + T G F + ++ D
Sbjct: 1270 ECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVH-----D 1324
Query: 213 QVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKC 272
+ IW GP ++ + + P + + + N + + F + GF ++
Sbjct: 1325 VLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDF-FTSKQGFAIQFSVST-- 1381
Query: 273 QALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHC 332
A + +P +P + R D++ G + C+PGY L+GS + C
Sbjct: 1382 -ATSCNDPGIP---------------QNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISC 1425
Query: 333 TPQGD---WSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSA 389
+ W P+ P C D G P+G +L P N CD K + +
Sbjct: 1426 VKIENRFFWQPSPPTCIAPCGGDLTG--PSGVILSP-NYPEPYPPGKECD----WKVTVS 1478
Query: 390 SYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGH 449
V+A + +++N P + ++ ++ + RI S + L
Sbjct: 1479 PDYVIALVFNIFNLE-PGYDFLHIYDGRDSLSPLIGSFYGSQLPGRIE-SSSNSLFLAFR 1536
Query: 450 SSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPD 509
S A +G ++ P + C +P +I NG G+ D+ G V+Y C
Sbjct: 1537 SDASVSNAGFVIDYTENP----RESCFDPGSIKNGTRVGS---DLKLGSSVTYYCHGG-- 1587
Query: 510 RGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVG 546
+ + G ST+ P G VW++P P C P G
Sbjct: 1588 ----YEVEGTSTLSCILGPDGKPVWNNPRPVCTAPCG 1620
Score = 62.0 bits (149), Expect = 1e-09
Identities = 102/464 (21%), Positives = 160/464 (34%), Gaps = 97/464 (20%)
Query: 92 KRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYR-LIGSSSATCIISGNTVIWDNKT 150
+ C +P PVNG +Q S I + C +G+ GS + TC++ +V+W++
Sbjct: 687 RHNECPDPGVPVNGKRFG-DSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNSAV 745
Query: 151 PVCDRIICGLPPTIANGDFTSISREYFHYGSVV---TYHCNLGSRGKKVFELVGEPSIYC 207
C+ CG T +G S F+ ++ G K F+ Y
Sbjct: 746 LRCEAP-CGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYD 804
Query: 208 TSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGP 267
T + +S AP + + P L+S + L+ L + GF ++
Sbjct: 805 TLEVRDGRTYS--APLIGVYHGTQVPQ----FLISTSNYLYLLFSTDKSHSDIGFQLRYE 858
Query: 268 SHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGS 327
+ + Q+ + +P +P QR ++F G V +SC+ GY L
Sbjct: 859 T-ITLQSDHCLDPGIPV---------------NGQRHGNDFYVGALVTFSCDSGYTLSDG 902
Query: 328 TYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFP---------------------- 365
L C P WS A P CE C F+ Q +G +L P
Sbjct: 903 EPLECEPNFQWSRALPSCEA-LCGGFI-QGSSGTILSPGFPDFYPNNLNCTWIIETSHGK 960
Query: 366 --------LNLQLGAKVDFVCDEGF------QLKGSSASYCVLAGMESLWNSSVPVC--- 408
+L+ G + + G QL GS + AG+ + + V
Sbjct: 961 GVFFTFHTFHLESGHDYLLITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDF 1020
Query: 409 --------------ERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAEC 454
+ + CE P VP + VG + +SC G+RL G + C
Sbjct: 1021 SMSYEGFNITFSEYDLEPCEEPEVPAYS-IRKGLQFGVGDTLTFSCFPGYRLEGTARITC 1079
Query: 455 ILSGNTAHWSMKPPIC------------QQIFCPNPPAILNGRH 486
L G WS P C + PN P N H
Sbjct: 1080 -LGGRRRLWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNH 1122
Score = 60.8 bits (146), Expect = 3e-09
Identities = 111/479 (23%), Positives = 176/479 (36%), Gaps = 64/479 (13%)
Query: 80 KNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCI- 138
K SV T C +P P G + D + S ++++C +GY L GS TC+
Sbjct: 327 KTSVLTQVGVSQGHNMCPDPGIPERGK-RLGSDFRLGSSVQFTCNEGYDLQGSKRITCMK 385
Query: 139 ISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFE 198
+S W + PVC +C +G TS + + + KV +
Sbjct: 386 VSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIK 445
Query: 199 LVGEPSIYCTSKDD-QVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFR 257
L E D VG Q + T +V + ++VS N ++ L +
Sbjct: 446 LAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPD-LIVSTNHQMWLLFQTDGSG 504
Query: 258 CQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYS 317
GF S+ + + + +P +P+ R R+ F G + +
Sbjct: 505 SSLGF---KASYEEIEQGSCGDPGIPAYGR---------------REGSRFHHGDTLKFE 546
Query: 318 CEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFV 377
C+P ++L G + C WS P C V SC F P+G VL P ++
Sbjct: 547 CQPAFELVGQKAITCQKNNQWSAKKPGC-VFSC-FFNFTSPSGVVLSP---------NYP 595
Query: 378 CDEGFQLKGSSASYCVLAGMES---LWNSSVPVCER------KSCETPPVPVNGMVHVIT 428
D G L + +LA ES L + + V + K T PV G
Sbjct: 596 EDYGNHL---HCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDGATAEAPVLGTFS--- 649
Query: 429 DIHVGSRINYSCT-TGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHT 487
G+++ S T +GH + + S +++ + CP+P +NG+
Sbjct: 650 ----GNQLPSSITSSGH--VARLEFQTDHSTGKRGFNITFTTFRHNECPDPGVPVNGKRF 703
Query: 488 GTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVG 546
G L G +S+ CD G TI + G+ VW+S RCE P G
Sbjct: 704 GDSL---QLGSSISFLCDEG-----FLGTQGSETITCVLK-EGSVVWNSAVLRCEAPCG 753
Score = 51.6 bits (122), Expect = 2e-06
Identities = 100/451 (22%), Positives = 152/451 (33%), Gaps = 89/451 (19%)
Query: 95 SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCII-SGNTVIWDNKTP-- 151
+C NP NG+ +++YSC G+ L G + TC S N+ WD P
Sbjct: 138 TCGNPGRLPNGIQQG-STFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSC 196
Query: 152 ----VCDRIICGLPPTIANGDFTSISREYFHYGSVV-TYHCNLGSRGKKVF---ELVGEP 203
C + G I++ F S EY + T LG VF +L
Sbjct: 197 RADDACGGTLRGQSGIISSPHFPS---EYHNNADCTWTILAELGDTIALVFIDFQLEDGY 253
Query: 204 SIYCTSKDDQVGIW----SGPAPQCIIPNKCTPPNVENGILVSDNRSL-FSLNEVVEFRC 258
+ + +W S PAP N +G S + + + +E +
Sbjct: 254 DFLEVTGTEGSSLWFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIELKS 313
Query: 259 QPGFGMK-GPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYS 317
+ G+K PS Q + S P P + ER +R +F G V ++
Sbjct: 314 R---GVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGI--PERGKRLGSDFRLGSSVQFT 368
Query: 318 CEPGYDLRGSTYLHCTPQGD----WSPAAPRCEVKSCDDFLGQLPNGHVLFP-------- 365
C GYDL+GS + C D WS P C + CD L + P+G + P
Sbjct: 369 CNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHL-RGPSGIITSPNFPIQYDN 427
Query: 366 -----------------------LNLQLGAKVDFVCDEG---------FQLKGSSASYCV 393
+L+ G V D G + L G+S +
Sbjct: 428 NAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPDLI 487
Query: 394 LAGMESLW--------------NSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYS 439
++ +W +S E+ SC P +P G + H G + +
Sbjct: 488 VSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDPGIPAYGR-REGSRFHHGDTLKFE 546
Query: 440 CTTGHRLIGHSSAECILSGNTAHWSMKPPIC 470
C L+G + C WS K P C
Sbjct: 547 CQPAFELVGQKAITC---QKNNQWSAKKPGC 574
Score = 46.2 bits (108), Expect = 8e-05
Identities = 100/436 (22%), Positives = 150/436 (34%), Gaps = 96/436 (22%)
Query: 96 CRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDR 155
C +P PVNG H D + + +SC GY L C + W P C+
Sbjct: 867 CLDPGIPVNGQRHG-NDFYVGALVTFSCDSGYTLSDGEPLECEPNFQ---WSRALPSCEA 922
Query: 156 IICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQV- 214
+ CG ++G S F+ ++ S GK VF + + S D +
Sbjct: 923 L-CGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFH--TFHLESGHDYLL 979
Query: 215 ----GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSH- 269
G ++ P Q + P + G+ + + +++ GF + +
Sbjct: 980 ITENGSFTQPLRQ--LTGSRLPAPISAGLYGNFTAQVRFISDFS--MSYEGFNITFSEYD 1035
Query: 270 -VKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGST 328
C+ EPE+P+ S R F G + +SC PGY L G+
Sbjct: 1036 LEPCE-----EPEVPAYSI---------------RKGLQFGVGDTLTFSCFPGYRLEGTA 1075
Query: 329 YLHCT--PQGDWSPAAPRCEVKSCDDFLGQLPNGHVL---FPLN---------------- 367
+ C + WS PRC + + G G +L FP+N
Sbjct: 1076 RITCLGGRRRLWSSPLPRCVAECGNSVTG--TQGTLLSPNFPVNYNNNHECIYSIQTQPG 1133
Query: 368 --LQLGAKVDFVCDEGFQLK-----GSSA------SYCVLAGM------ESLWNSSVPVC 408
+QL A+ F EG LK +SA S+ + G+ SLW +
Sbjct: 1134 KGIQLKARA-FELSEGDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDA 1192
Query: 409 ERKS--------------CETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAEC 454
E S CE P P G GS +++SC G+ L G C
Sbjct: 1193 ENTSKGFELHFSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLC 1252
Query: 455 ILSGNTAHWSMKPPIC 470
LSG W P C
Sbjct: 1253 -LSGERRTWDRPLPTC 1267
Score = 42.4 bits (98), Expect = 0.001
Identities = 19/65 (29%), Positives = 34/65 (52%), Gaps = 6/65 (9%)
Query: 228 NKCTPPNV-ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQ--ALNKWEPELPS 284
+ C P V NG+ + + +N+VV F+C+PG+ ++G +H+ C + +W P
Sbjct: 1907 SSCPEPAVPSNGVKTGER---YLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPL 1963
Query: 285 CSRVC 289
C C
Sbjct: 1964 CIAQC 1968
Score = 40.4 bits (93), Expect = 0.004
Identities = 82/360 (22%), Positives = 120/360 (33%), Gaps = 82/360 (22%)
Query: 228 NKCTPPNVE-NGILVSDNRSLFSLNEVVEFRCQPGF-GMKGPSHVKC---QALNKWEPEL 282
N+C P V NG D+ L + F C GF G +G + C + W +
Sbjct: 689 NECPDPGVPVNGKRFGDS---LQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNSAV 745
Query: 283 PSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFY----SC------EPGYDLRGSTYLHC 332
C C T SPG FY SC +PGY ++ T+
Sbjct: 746 LRCEAPCG-------GHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIK-ITFDRF 797
Query: 333 TPQGDWSPAAPRCEVKSCDDFLG-----QLPNGHVLFPLNLQLGAKVDFV-CDEGFQLKG 386
+ ++ R +G Q+P + L L D D GFQL+
Sbjct: 798 KTEVNYDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRY 857
Query: 387 SSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRL 446
+ + + C P +PVNG H D +VG+ + +SC +G+ L
Sbjct: 858 ETITL-----------------QSDHCLDPGIPVNGQRHG-NDFYVGALVTFSCDSGYTL 899
Query: 447 IGHSSAECILSGNTAHWSMKPPICQ------------QIFCPNPPAILNGRHTGTPLGDI 494
EC WS P C+ I P P T + +
Sbjct: 900 SDGEPLEC---EPNFQWSRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIET 956
Query: 495 PYGKEVSYTCDP-HPDRGMTFNLIGESTIRRTSEPHGNGVWSSP-----APRCELPVGAG 548
+GK V +T H + G + LI E NG ++ P R P+ AG
Sbjct: 957 SHGKGVFFTFHTFHLESGHDYLLITE-----------NGSFTQPLRQLTGSRLPAPISAG 1005
Score = 39.7 bits (91), Expect = 0.008
Identities = 96/486 (19%), Positives = 167/486 (34%), Gaps = 72/486 (14%)
Query: 96 CRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCI-ISGNTVIWDNKTPVCD 154
C + P+P G + D + +++ C GY L GS C+ + G W+ P C
Sbjct: 1735 CSSVPEPRYGK-RLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCV 1793
Query: 155 RIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQV 214
+ CG T G S + S+ + G + + S D +
Sbjct: 1794 -VPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGI--QIQVVSFVTEQNWDSL 1850
Query: 215 GIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQA 274
++ G + + V +L S + L+ + F G H++ +
Sbjct: 1851 EVFDGADNTVTMLGSFSGTTVP-ALLNSTSNQLY-----LHFYSDISVSAAG-FHLEYKT 1903
Query: 275 LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTP 334
+ L SC P V ER + V + CEPGY L+G ++ C P
Sbjct: 1904 VG-----LSSCPEPAVPSNGVKTGER-------YLVNDVVSFQCEPGYALQGHAHISCMP 1951
Query: 335 --QGDWSPAAPRCEVKSCDDFLGQLPNGHVL-------FPLNLQLGAKVDFVCDEGFQLK 385
W+ P C + C + ++ G +L +P N+ K+ G ++
Sbjct: 1952 GTVRRWNYPPPLC-IAQCGGTVEEM-EGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQ 2009
Query: 386 ----GSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIH-------VGS 434
+ ++ + + +S + E P ++ H G
Sbjct: 2010 FLNFSTEPNHDYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGF 2069
Query: 435 RINY-SCTTGHR----LIGHSSAECILSGNTAH------WSMKPPICQQI---FCPNPPA 480
++ Y T H+ L G +E + +T W + P C+ CP+P
Sbjct: 2070 KLEYQDLTYSHQISSFLRGFDLSELERTNSTPPVAASYVWDLDPG-CEAYELQECPDPEP 2128
Query: 481 ILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPR 540
NG G G+ V++ C P + L G + T + N W P P+
Sbjct: 2129 FANGIVRGAGYN---VGQSVTFECLP------GYQLTGHPVL--TCQHGTNRNWDHPLPK 2177
Query: 541 CELPVG 546
CE+P G
Sbjct: 2178 CEVPCG 2183
Score = 35.0 bits (79), Expect = 0.18
Identities = 26/101 (25%), Positives = 42/101 (41%), Gaps = 11/101 (10%)
Query: 381 GFQLKGSSASYCVLAGMESL---------WNSSVPVCERKSCETPPVPVNGMVHVITDIH 431
GFQL + S + + ++++ V +C P NG+ T +
Sbjct: 98 GFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEVLPSHTCGNPGRLPNGIQQGST-FN 156
Query: 432 VGSRINYSCTTGHRLIGHSSAECIL-SGNTAHWSMKPPICQ 471
+G ++ YSC G L GH+ C S N+A W P C+
Sbjct: 157 LGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCR 197
>gi|157419154 selectin P precursor [Homo sapiens]
Length = 830
Score = 162 bits (411), Expect = 6e-40
Identities = 139/513 (27%), Positives = 200/513 (38%), Gaps = 59/513 (11%)
Query: 55 FPIGTYLNYECRPGYS-GRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNG---MAHVI 110
F + ++ C GY P + CL + +WT+ +C C P G H
Sbjct: 220 FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSA 279
Query: 111 KDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFT 170
K Q +S +SC +G+ L+G C SG +W PVC + C + G
Sbjct: 280 KAFQHQSSCSFSCEEGFALVGPEVVQCTASG---VWTAPAPVCKAVQCQHLEAPSEGTMD 336
Query: 171 SI-SREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNK 229
+ F YGS + C G R + G + C G WS P P C +
Sbjct: 337 CVHPLTAFAYGSSCKFECQPGYRVR------GLDMLRCIDS----GHWSAPLPTCEAIS- 385
Query: 230 CTP--PNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSR 287
C P V + S + F + FRC GF ++G V+C L +W P C
Sbjct: 386 CEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQA 445
Query: 288 V-CQPPPDVLHAE-RTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC 345
+ CQ P A F ++C G L G++ L C G+W+ P C
Sbjct: 446 LQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPEC 505
Query: 346 EVKSCDDFLGQLPNGHV--LFPL-NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWN 402
+ C L NG + + PL + + F+CDEG+ L G C +G W
Sbjct: 506 QAIPCTPLLSP-QNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR---WT 561
Query: 403 SSVPVCERKSCETPPVPVNGMVHVIT---DIHVGSRINYSCTTGHRLIGHSSAECILSGN 459
S P+CE C P G + + +VGS ++SC G +L G ++ EC SG
Sbjct: 562 DSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSG- 620
Query: 460 TAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDR--------- 510
WS PP C+ I P + T TP G+ Y C HP
Sbjct: 621 --RWSATPPTCKGIASLPTPGVQCPALT-TP------GQGTMY-CRHHPGTFGFNTTCYF 670
Query: 511 --GMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
F LIG+ST+ + P +G W++ P C
Sbjct: 671 GCNAGFTLIGDSTL--SCRP--SGQWTAVTPAC 699
Score = 158 bits (400), Expect = 1e-38
Identities = 123/464 (26%), Positives = 187/464 (40%), Gaps = 59/464 (12%)
Query: 99 PPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIIC 158
P + +H + + F SQ + C GY++ G S C+ SG IW NK P C C
Sbjct: 206 PQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASG---IWTNKPPQCLAAQC 262
Query: 159 GLPPTIANGDFTSI-SREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217
G+ T + S + F + S ++ C G F LVG + CT+ G+W
Sbjct: 263 PPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEG------FALVGPEVVQCTAS----GVW 312
Query: 218 SGPAPQC-IIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALN 276
+ PAP C + + E + + F+ +F CQPG+ ++G ++C
Sbjct: 313 TAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSG 372
Query: 277 KWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVF-------YSCEPGYDLRGST 328
W LP+C + C+P +H + SP F + C G+ LRG+
Sbjct: 373 HWSAPLPTCEAISCEPLESPVHGSM------DCSPSLRAFQYDTNCSFRCAEGFMLRGAD 426
Query: 329 YLHCTPQGDWSPAAPRCEVKSCDDFLGQLPN------GHVLFPLNLQLGAKVDFVCDEGF 382
+ C G W+ AP C+ C D +PN H Q + F C+EG
Sbjct: 427 IVRCDNLGQWTAPAPVCQALQCQDL--PVPNEARVNCSHPFGAFRYQ--SVCSFTCNEGL 482
Query: 383 QLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDI---HVGSRINYS 439
L G+S C+ G WNS P C+ C P NG + + + S +
Sbjct: 483 LLVGASVLQCLATGN---WNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFI 539
Query: 440 CTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGR-HTGTPLGDIPYGK 498
C G+ L G +C SG W+ PP+C+ I CP A G G+ G
Sbjct: 540 CDEGYSLSGPERLDCTRSG---RWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGS 596
Query: 499 EVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542
++CD F L G + + T+ +G WS+ P C+
Sbjct: 597 TCHFSCD------NGFKLEGPNNVECTT----SGRWSATPPTCK 630
Score = 149 bits (375), Expect = 9e-36
Identities = 130/508 (25%), Positives = 194/508 (38%), Gaps = 61/508 (12%)
Query: 62 NYECRPGYS-GRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNG---MAHVIKDIQFRS 117
++ C G++ P + C + VWT+ CK C++ P G H + + S
Sbjct: 289 SFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGS 348
Query: 118 QIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDF-TSISREY 176
K+ C GYR+ G CI SG+ W P C+ I C + +G S S
Sbjct: 349 SCKFECQPGYRVRGLDMLRCIDSGH---WSAPLPTCEAISCEPLESPVHGSMDCSPSLRA 405
Query: 177 FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQC-IIPNKCTPPNV 235
F Y + ++ C G F L G + C D +G W+ PAP C + + P
Sbjct: 406 FQYDTNCSFRCAEG------FMLRGADIVRC----DNLGQWTAPAPVCQALQCQDLPVPN 455
Query: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV-CQPPPD 294
E + S F V F C G + G S ++C A W P C + C P
Sbjct: 456 EARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLS 515
Query: 295 VLHAERT-QRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDF 353
+ T + + S + C+ GY L G L CT G W+ + P CE C +
Sbjct: 516 PQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPEL 575
Query: 354 L----GQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE 409
G L N +G+ F CD GF+L+G + C +G W+++ P C+
Sbjct: 576 FAPEQGSLDCSDTRGEFN--VGSTCHFSCDNGFKLEGPNNVECTTSGR---WSATPPTCK 630
Query: 410 ------RKSCETPPVPVNGMVHVITDIHVG-----SRINYSCTTGHRLIGHSSAECILSG 458
+ P + G + H G + + C G LIG S+ C SG
Sbjct: 631 GIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSG 690
Query: 459 NTAHWSMKPPICQQIFCP----NPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTF 514
W+ P C+ + C N P +N G+ YG S+ C +
Sbjct: 691 ---QWTAVTPACRAVKCSELHVNKPIAMN---CSNLWGNFSYGSICSFHC-------LEG 737
Query: 515 NLIGESTIRRTSEPHGNGVWSSPAPRCE 542
L+ S E NG WS+ P C+
Sbjct: 738 QLLNGSAQTACQE---NGHWSTTVPTCQ 762
Score = 125 bits (313), Expect = 1e-28
Identities = 98/383 (25%), Positives = 151/383 (39%), Gaps = 54/383 (14%)
Query: 55 FPIGTYLNYECRPGYSGRPFSII-CLKNSVWTSAKDKCKRKSCRNPPDPVNGM---AHVI 110
F T ++ C G+ R I+ C WT+ C+ C++ P P +H
Sbjct: 406 FQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPF 465
Query: 111 KDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFT 170
+++S ++C +G L+G+S C+ +GN W++ P C I C + NG T
Sbjct: 466 GAFRYQSVCSFTCNEGLLLVGASVLQCLATGN---WNSVPPECQAIPCTPLLSPQNGTMT 522
Query: 171 SISR-EYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCII--- 226
+ Y S + C+ G + L G + CT G W+ P C
Sbjct: 523 CVQPLGSSSYKSTCQFICDEG------YSLSGPERLDCTRS----GRWTDSPPMCEAIKC 572
Query: 227 PNKCTPPNVENGIL-VSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSC 285
P P E G L SD R F++ F C GF ++GP++V+C +W P+C
Sbjct: 573 PELFAP---EQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTC 629
Query: 286 SRVCQ-PPPDVLHAERT---------QRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQ 335
+ P P V T + F ++ C G+ L G + L C P
Sbjct: 630 KGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPS 689
Query: 336 GDWSPAAPRCEVKSCDDFLGQLPNGHVLFPL---------NLQLGAKVDFVCDEGFQLKG 386
G W+ P C C + HV P+ N G+ F C EG L G
Sbjct: 690 GQWTAVTPACRAVKCSEL-------HVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNG 742
Query: 387 SSASYCVLAGMESLWNSSVPVCE 409
S+ + C G W+++VP C+
Sbjct: 743 SAQTACQENGH---WSTTVPTCQ 762
Score = 53.1 bits (126), Expect = 7e-07
Identities = 41/144 (28%), Positives = 66/144 (45%), Gaps = 22/144 (15%)
Query: 406 PVCER-KSC---ETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTA 461
P CE + C E P + H + + S+ ++ CT G+++ G S EC+ SG
Sbjct: 192 PECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASG--- 248
Query: 462 HWSMKPPICQQIFCPNPPAILNGRHTGTPLGD---IPYGKEVSYTCDPHPDRGMTFNLIG 518
W+ KPP C C PP + R T L + S++C+ F L+G
Sbjct: 249 IWTNKPPQCLAAQC--PPLKIPERGNMTCLHSAKAFQHQSSCSFSCEE------GFALVG 300
Query: 519 ESTIRRTSEPHGNGVWSSPAPRCE 542
++ T+ +GVW++PAP C+
Sbjct: 301 PEVVQCTA----SGVWTAPAPVCK 320
>gi|168693643 decay accelerating factor for complement isoform 2
precursor [Homo sapiens]
Length = 440
Score = 155 bits (392), Expect = 9e-38
Identities = 89/222 (40%), Positives = 123/222 (55%), Gaps = 21/222 (9%)
Query: 15 RFPGLLLAALVLLLSSFSD-------QCNVPEWLPFA--RPTNLTDDFEFPIGTYLNYEC 65
+ PG + + L S +SD C VP L A + +T ++ FP+GT + YEC
Sbjct: 71 KIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNY-FPVGTVVEYEC 129
Query: 66 RPGYSGRPF---SIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYS 122
RPGY P + CL+N W++A + CK+KSC NP + NG V I F + I +S
Sbjct: 130 RPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFS 189
Query: 123 CPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSV 182
C GY+L GS+S+ C+ISG++V W + P C I C PP I NG R+++ Y
Sbjct: 190 CNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQG-ERDHYGYRQS 248
Query: 183 VTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQC 224
VTY CN G F ++GE SIYCT +D+ G WSGP P+C
Sbjct: 249 VTYACNKG------FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283
Score = 127 bits (318), Expect = 4e-29
Identities = 90/320 (28%), Positives = 140/320 (43%), Gaps = 34/320 (10%)
Query: 232 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSH---VKCQALNKWEPELPSCSRV 288
PP+V N + R+ F + V+ ++C+ F +K P V C ++W C+R
Sbjct: 39 PPDVPNAQPALEGRTSFPEDTVITYKCEESF-VKIPGEKDSVICLKGSQWSDIEEFCNRS 97
Query: 289 CQPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDLRGSTY--LHCTPQGDWSPAAPR 344
C+ P + A Q ++ F G V Y C PGY S L C WS A
Sbjct: 98 CEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEF 157
Query: 345 CEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSS 404
C+ KSC + G++ NG + P + GA + F C+ G++L GS++S+C+++G W+
Sbjct: 158 CKKKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDP 216
Query: 405 VPVCERKSCETPPVPVNGMVHVITDIHVGSR--INYSCTTGHRLIGHSSAECILSGNTAH 462
+P C C PP NG++ D H G R + Y+C G +IG S C ++ +
Sbjct: 217 LPECREIYCPAPPQIDNGIIQGERD-HYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGE 275
Query: 463 WSMKPPIC--QQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGES 520
WS PP C + + PP + P EVS T +
Sbjct: 276 WSGPPPECRGKSLTSKVPPTVQKPTTVNVPT------TEVSPT--------------SQK 315
Query: 521 TIRRTSEPHGNGVWSSPAPR 540
T +T+ P+ S+P R
Sbjct: 316 TTTKTTTPNAQATRSTPVSR 335
Score = 114 bits (286), Expect = 2e-25
Identities = 81/267 (30%), Positives = 131/267 (49%), Gaps = 19/267 (7%)
Query: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-DLRGST-YLHCTPQGDWS 339
LP+ C PPDV +A+ + +F + Y CE + + G + C WS
Sbjct: 29 LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88
Query: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLNLQ----LGAKVDFVCDEGFQLKGSSASYCVLA 395
C +SC+ +L + + P Q +G V++ C G++ + S + L
Sbjct: 89 DIEEFCN-RSCE-VPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPK--LT 144
Query: 396 GMESL-WNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAEC 454
+++L W+++V C++KSC P NG + V I G+ I++SC TG++L G +S+ C
Sbjct: 145 CLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFC 204
Query: 455 ILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTF 514
++SG++ WS P C++I+CP PP I NG G Y + V+Y C+ F
Sbjct: 205 LISGSSVQWSDPLPECREIYCPAPPQIDNGIIQG-ERDHYGYRQSVTYACN------KGF 257
Query: 515 NLIGESTIRRTSEPHGNGVWSSPAPRC 541
+IGE +I T + G WS P P C
Sbjct: 258 TMIGEHSIYCTVN-NDEGEWSGPPPEC 283
Score = 79.7 bits (195), Expect = 7e-15
Identities = 64/265 (24%), Positives = 103/265 (38%), Gaps = 24/265 (9%)
Query: 96 CRNPPDPVNGMAHVIKDIQFRSQ--IKYSCPKGY-RLIGSSSATCIISGNTVIWDNKTPV 152
C PPD N + F I Y C + + ++ G + + G+ W +
Sbjct: 36 CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQ--WSDIEEF 93
Query: 153 CDRIICGLPPTIANGDFTS--ISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSK 210
C+R C +P + + I++ YF G+VV Y C G R + P + C
Sbjct: 94 CNRS-CEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLS----PKLTCLQN 148
Query: 211 DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHV 270
WS C + P + NG + LF + F C G+ + G +
Sbjct: 149 LK----WSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGAT--ISFSCNTGYKLFGSTSS 202
Query: 271 KCQALN---KWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGS 327
C +W LP C + P P + Q ++D++ Q V Y+C G+ + G
Sbjct: 203 FCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGE 262
Query: 328 TYLHCT---PQGDWSPAAPRCEVKS 349
++CT +G+WS P C KS
Sbjct: 263 HSIYCTVNNDEGEWSGPPPECRGKS 287
>gi|10835143 decay accelerating factor for complement isoform 1
preproprotein [Homo sapiens]
Length = 381
Score = 155 bits (392), Expect = 9e-38
Identities = 89/222 (40%), Positives = 123/222 (55%), Gaps = 21/222 (9%)
Query: 15 RFPGLLLAALVLLLSSFSD-------QCNVPEWLPFA--RPTNLTDDFEFPIGTYLNYEC 65
+ PG + + L S +SD C VP L A + +T ++ FP+GT + YEC
Sbjct: 71 KIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNY-FPVGTVVEYEC 129
Query: 66 RPGYSGRPF---SIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYS 122
RPGY P + CL+N W++A + CK+KSC NP + NG V I F + I +S
Sbjct: 130 RPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFS 189
Query: 123 CPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSV 182
C GY+L GS+S+ C+ISG++V W + P C I C PP I NG R+++ Y
Sbjct: 190 CNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQG-ERDHYGYRQS 248
Query: 183 VTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQC 224
VTY CN G F ++GE SIYCT +D+ G WSGP P+C
Sbjct: 249 VTYACNKG------FTMIGEHSIYCTVNNDE-GEWSGPPPEC 283
Score = 127 bits (318), Expect = 4e-29
Identities = 90/320 (28%), Positives = 140/320 (43%), Gaps = 34/320 (10%)
Query: 232 PPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSH---VKCQALNKWEPELPSCSRV 288
PP+V N + R+ F + V+ ++C+ F +K P V C ++W C+R
Sbjct: 39 PPDVPNAQPALEGRTSFPEDTVITYKCEESF-VKIPGEKDSVICLKGSQWSDIEEFCNRS 97
Query: 289 CQPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDLRGSTY--LHCTPQGDWSPAAPR 344
C+ P + A Q ++ F G V Y C PGY S L C WS A
Sbjct: 98 CEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEF 157
Query: 345 CEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSS 404
C+ KSC + G++ NG + P + GA + F C+ G++L GS++S+C+++G W+
Sbjct: 158 CKKKSCPN-PGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDP 216
Query: 405 VPVCERKSCETPPVPVNGMVHVITDIHVGSR--INYSCTTGHRLIGHSSAECILSGNTAH 462
+P C C PP NG++ D H G R + Y+C G +IG S C ++ +
Sbjct: 217 LPECREIYCPAPPQIDNGIIQGERD-HYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGE 275
Query: 463 WSMKPPIC--QQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGES 520
WS PP C + + PP + P EVS T +
Sbjct: 276 WSGPPPECRGKSLTSKVPPTVQKPTTVNVPT------TEVSPT--------------SQK 315
Query: 521 TIRRTSEPHGNGVWSSPAPR 540
T +T+ P+ S+P R
Sbjct: 316 TTTKTTTPNAQATRSTPVSR 335
Score = 114 bits (286), Expect = 2e-25
Identities = 81/267 (30%), Positives = 131/267 (49%), Gaps = 19/267 (7%)
Query: 282 LPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-DLRGST-YLHCTPQGDWS 339
LP+ C PPDV +A+ + +F + Y CE + + G + C WS
Sbjct: 29 LPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWS 88
Query: 340 PAAPRCEVKSCDDFLGQLPNGHVLFPLNLQ----LGAKVDFVCDEGFQLKGSSASYCVLA 395
C +SC+ +L + + P Q +G V++ C G++ + S + L
Sbjct: 89 DIEEFCN-RSCE-VPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPK--LT 144
Query: 396 GMESL-WNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAEC 454
+++L W+++V C++KSC P NG + V I G+ I++SC TG++L G +S+ C
Sbjct: 145 CLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFC 204
Query: 455 ILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTF 514
++SG++ WS P C++I+CP PP I NG G Y + V+Y C+ F
Sbjct: 205 LISGSSVQWSDPLPECREIYCPAPPQIDNGIIQG-ERDHYGYRQSVTYACN------KGF 257
Query: 515 NLIGESTIRRTSEPHGNGVWSSPAPRC 541
+IGE +I T + G WS P P C
Sbjct: 258 TMIGEHSIYCTVN-NDEGEWSGPPPEC 283
Score = 79.7 bits (195), Expect = 7e-15
Identities = 64/265 (24%), Positives = 103/265 (38%), Gaps = 24/265 (9%)
Query: 96 CRNPPDPVNGMAHVIKDIQFRSQ--IKYSCPKGY-RLIGSSSATCIISGNTVIWDNKTPV 152
C PPD N + F I Y C + + ++ G + + G+ W +
Sbjct: 36 CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQ--WSDIEEF 93
Query: 153 CDRIICGLPPTIANGDFTS--ISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSK 210
C+R C +P + + I++ YF G+VV Y C G R + P + C
Sbjct: 94 CNRS-CEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLS----PKLTCLQN 148
Query: 211 DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHV 270
WS C + P + NG + LF + F C G+ + G +
Sbjct: 149 LK----WSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGAT--ISFSCNTGYKLFGSTSS 202
Query: 271 KCQALN---KWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGS 327
C +W LP C + P P + Q ++D++ Q V Y+C G+ + G
Sbjct: 203 FCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGE 262
Query: 328 TYLHCT---PQGDWSPAAPRCEVKS 349
++CT +G+WS P C KS
Sbjct: 263 HSIYCTVNNDEGEWSGPPPECRGKS 287
>gi|187960042 selectin E precursor [Homo sapiens]
Length = 610
Score = 145 bits (366), Expect = 1e-34
Identities = 116/441 (26%), Positives = 173/441 (39%), Gaps = 53/441 (12%)
Query: 57 IGTYLNYECR--PGYSGRPFSIICLKNSVWTSAKDKCKR-KSCRNPPDPVNGM---AHVI 110
+ T NY C+ PG+SG KC++ +C P +G +H +
Sbjct: 155 VETINNYTCKCDPGFSGL-----------------KCEQIVNCTALESPEHGSLVCSHPL 197
Query: 111 KDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFT 170
+ + S SC +GY + C+ SG W P C+ + C ANG
Sbjct: 198 GNFSYNSSCSISCDRGYLPSSMETMQCMSSGE---WSAPIPACNVVECDAVTNPANGFVE 254
Query: 171 SISRE-YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNK 229
F + + T+ C G FEL+G S+ CTS G W P C
Sbjct: 255 CFQNPGSFPWNTTCTFDCEEG------FELMGAQSLQCTSS----GNWDNEKPTCKAVTC 304
Query: 230 CTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSR 287
+NG + + F+ F C+ GF ++GP+ V+C +W ++P C
Sbjct: 305 RAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEA 364
Query: 288 ---VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPR 344
P+ + +F G +SCE G+ L+GS L C P G+W P
Sbjct: 365 FQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPT 424
Query: 345 CEVKSCDDFLGQLPNGHVL---FPL-NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL 400
CE C D + Q P G V P+ + F C+EGF+L GS+ C G
Sbjct: 425 CEAVRC-DAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ--- 480
Query: 401 WNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNT 460
W VP C+ C + VP + + G+ ++C G L G ++ C G T
Sbjct: 481 WTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTC---GAT 537
Query: 461 AHWSMKPPICQQIFCPNPPAI 481
HWS P C+ N P +
Sbjct: 538 GHWSGLLPTCEAPTESNIPLV 558
Score = 139 bits (349), Expect = 9e-33
Identities = 98/373 (26%), Positives = 150/373 (40%), Gaps = 42/373 (11%)
Query: 55 FPIGTYLNYECRPGYSGRPFSII-CLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKD- 112
F + + C GY + C+ + W++ C C +P NG ++
Sbjct: 200 FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNP 259
Query: 113 --IQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDF- 169
+ + + C +G+ L+G+ S C SGN WDN+ P C + C NG
Sbjct: 260 GSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVR 316
Query: 170 -TSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPN 228
+ F + S + C G F L G + CT++ G W+ P C
Sbjct: 317 CSHSPAGEFTFKSSCNFTCEEG------FMLQGPAQVECTTQ----GQWTQQIPVCEAFQ 366
Query: 229 KCTPPNVENGIL--VSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCS 286
N E G + + F EF C+ GF +KG ++C +W+ E P+C
Sbjct: 367 CTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCE 426
Query: 287 RV-C----QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPA 341
V C QPP ++ + + F+ +SCE G++L GST L CT QG W+
Sbjct: 427 AVRCDAVHQPPKGLVRCAHSPIGE--FTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEE 484
Query: 342 APRCEVKSCDDF-----LGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAG 396
P C+V C + +G +F G F C EG+ L GS+A C G
Sbjct: 485 VPSCQVVKCSSLAVPGKINMSCSGEPVF------GTVCKFACPEGWTLNGSAARTC---G 535
Query: 397 MESLWNSSVPVCE 409
W+ +P CE
Sbjct: 536 ATGHWSGLLPTCE 548
Score = 129 bits (323), Expect = 9e-30
Identities = 103/387 (26%), Positives = 148/387 (38%), Gaps = 55/387 (14%)
Query: 177 FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVE 236
F Y S + C+ G PS T + G WS P P C + N
Sbjct: 200 FSYNSSCSISCDRGYL----------PSSMETMQCMSSGEWSAPIPACNVVECDAVTNPA 249
Query: 237 NGILVS-DNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVC-----Q 290
NG + N F N F C+ GF + G ++C + W+ E P+C V Q
Sbjct: 250 NGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQ 309
Query: 291 PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSC 350
P + + + F ++CE G+ L+G + CT QG W+ P CE C
Sbjct: 310 PQNGSVRCSHSPAGEFTFKSSCN--FTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQC 367
Query: 351 D-------DFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS 403
++ LP+ F + G+ +F C++GF LKGS C G W++
Sbjct: 368 TALSNPERGYMNCLPSASGSF----RYGSSCEFSCEQGFVLKGSKRLQC---GPTGEWDN 420
Query: 404 SVPVCERKSCETPPVPVNGMVHV----ITDIHVGSRINYSCTTGHRLIGHSSAECILSGN 459
P CE C+ P G+V I + S +SC G L G + EC G
Sbjct: 421 EKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQG- 479
Query: 460 TAHWSMKPPICQQIFCPN--PPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLI 517
W+ + P CQ + C + P +N +G P+ +G + C G T N
Sbjct: 480 --QWTEEVPSCQVVKCSSLAVPGKINMSCSGEPV----FGTVCKFAC----PEGWTLNGS 529
Query: 518 GESTIRRTSEPHGNGVWSSPAPRCELP 544
T T G WS P CE P
Sbjct: 530 AARTCGAT------GHWSGLLPTCEAP 550
Score = 92.0 bits (227), Expect = 1e-18
Identities = 79/296 (26%), Positives = 108/296 (36%), Gaps = 43/296 (14%)
Query: 257 RCQPGF-GMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVF 315
+C PGF G+K V C AL E S VC P NFS
Sbjct: 164 KCDPGFSGLKCEQIVNCTALESPEHG----SLVCSHP------------LGNFSYNSSCS 207
Query: 316 YSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHV---LFPLNLQLGA 372
SC+ GY + C G+WS P C V CD NG V P +
Sbjct: 208 ISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNP-ANGFVECFQNPGSFPWNT 266
Query: 373 KVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHV----IT 428
F C+EGF+L G+ + C +G W++ P C+ +C P NG V
Sbjct: 267 TCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAG 323
Query: 429 DIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTG 488
+ S N++C G L G + EC G W+ + P+C+ C G
Sbjct: 324 EFTFKSSCNFTCEEGFMLQGPAQVECTTQG---QWTQQIPVCEAFQCTALSNPERGYMNC 380
Query: 489 TP--LGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542
P G YG ++C+ F L G + + G W + P CE
Sbjct: 381 LPSASGSFRYGSSCEFSCE------QGFVLKGSKRL----QCGPTGEWDNEKPTCE 426
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.139 0.460
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,002,738
Number of Sequences: 37866
Number of extensions: 1591268
Number of successful extensions: 5935
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 81
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 2866
Number of HSP's gapped (non-prelim): 915
length of query: 569
length of database: 18,247,518
effective HSP length: 108
effective length of query: 461
effective length of database: 14,157,990
effective search space: 6526833390
effective search space used: 6526833390
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.