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Search of human proteins with 148539879
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens]
(688 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens] 1411 0.0
gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens] 1215 0.0
gi|51896037 G protein-coupled receptor kinase 6 isoform C [Homo ... 317 2e-86
gi|51896039 G protein-coupled receptor kinase 6 isoform A [Homo ... 317 2e-86
gi|51896035 G protein-coupled receptor kinase 6 isoform B [Homo ... 317 2e-86
gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [H... 311 2e-84
gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [H... 308 8e-84
gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Ho... 307 2e-83
gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens] 306 5e-83
gi|4506529 rhodopsin kinase [Homo sapiens] 269 6e-72
gi|21166359 G-protein-coupled receptor kinase 7 [Homo sapiens] 268 1e-71
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 217 3e-56
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 216 6e-56
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 216 6e-56
gi|62241015 AKT1 kinase [Homo sapiens] 215 1e-55
gi|62241013 AKT1 kinase [Homo sapiens] 215 1e-55
gi|62241011 AKT1 kinase [Homo sapiens] 215 1e-55
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 214 2e-55
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 214 2e-55
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 213 4e-55
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 213 4e-55
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 213 4e-55
gi|4502023 AKT2 kinase [Homo sapiens] 212 1e-54
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 210 4e-54
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 210 4e-54
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 210 4e-54
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 210 4e-54
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 196 6e-50
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 196 6e-50
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 196 6e-50
>gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens]
Length = 688
Score = 1411 bits (3653), Expect = 0.0
Identities = 688/688 (100%), Positives = 688/688 (100%)
Query: 1 MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN 60
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN
Sbjct: 1 MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN 60
Query: 61 QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC 120
QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC
Sbjct: 61 QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC 120
Query: 121 SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV 180
SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
Sbjct: 121 SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV 180
Query: 181 ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240
ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
Sbjct: 181 ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240
Query: 241 IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE 300
IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE
Sbjct: 241 IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE 300
Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPE 360
IILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPE
Sbjct: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPE 360
Query: 361 VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE 420
VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE
Sbjct: 361 VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE 420
Query: 421 LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA 480
LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA
Sbjct: 421 LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA 480
Query: 481 DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARK 540
DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARK
Sbjct: 481 DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARK 540
Query: 541 RAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNL 600
RAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNL
Sbjct: 541 RAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNL 600
Query: 601 LTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRR 660
LTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRR
Sbjct: 601 LTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRR 660
Query: 661 APKFLNKPRSGTVELPKPSLCHRNSNGL 688
APKFLNKPRSGTVELPKPSLCHRNSNGL
Sbjct: 661 APKFLNKPRSGTVELPKPSLCHRNSNGL 688
>gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens]
Length = 689
Score = 1215 bits (3143), Expect = 0.0
Identities = 579/689 (84%), Positives = 639/689 (92%), Gaps = 1/689 (0%)
Query: 1 MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN 60
MADLEAVLADVSYLMAMEKSKATPAARASK+I+LPEPSIRSVMQKYL +R E+TF+KIF+
Sbjct: 1 MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS 60
Query: 61 QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC 120
QK+G+LLF+DFCLN + EA P V+FYEEIK+YEKL+ EE+R+ RSR+I+D+YIMKELL+C
Sbjct: 61 QKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLAC 120
Query: 121 SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV 180
SHPFSK A EHVQ HL KKQV LFQPYIEEIC++LRGD+FQKF+ESDKFTRFCQWKNV
Sbjct: 121 SHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV 180
Query: 181 ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240
ELNIHLTMN+FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
Sbjct: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240
Query: 241 IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE 300
IMLSLVSTGDCPFIVCM+YAFHTPDKL FILDLMNGGDLHYHLSQHGVFSE +MRFYA E
Sbjct: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE 300
Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPE 360
IILGLEHMHNRFVVYRDLKPANILLDEHGH RISDLGLACDFSKKKPHASVGTHGYMAPE
Sbjct: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE 360
Query: 361 VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE 420
VLQKG AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLT+ VELPD+FSPE
Sbjct: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420
Query: 421 LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA 480
L+SLLEGLLQRDV++RLGC G G+QEVKE FF+ +DWQ V+LQKYPPPLIPPRGEVNAA
Sbjct: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA 480
Query: 481 DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARK 540
DAFDIGSFDEEDTKGIKLLD DQELY+NFPL ISERWQQEV ETV++ +NA+TD++EARK
Sbjct: 481 DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK 540
Query: 541 RAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNL 600
+AKNKQLGHEEDYALGKDCIMHGYM K+GNPFLTQWQRRYFYLFPNRLEWRGEGE+ Q+L
Sbjct: 541 KAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL 600
Query: 601 LTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRR 660
LTME+I SVEETQIK++KC+L +I+GGKQF+LQC+SDPE VQWKKEL + ++EAQ+L++R
Sbjct: 601 LTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQR 660
Query: 661 APKFLNKPRSGTVELPKPSLCHRNS-NGL 688
PK NKPRS VEL K L R S NGL
Sbjct: 661 VPKMKNKPRSPVVELSKVPLVQRGSANGL 689
>gi|51896037 G protein-coupled receptor kinase 6 isoform C [Homo
sapiens]
Length = 560
Score = 317 bits (813), Expect = 2e-86
Identities = 206/530 (38%), Positives = 292/530 (55%), Gaps = 21/530 (3%)
Query: 3 DLEAVLADVSYLMAMEKSKATPAARASK-RIVLPEPSIRSVMQKYLA-ERNEITFDKIFN 60
+LE ++A+ L A E ++ K R +L P I + L+ ER+ + +
Sbjct: 2 ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCE--R 59
Query: 61 QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC 120
Q IG LLF++FC E V F + + EYE +++ + C RQ+ ++
Sbjct: 60 QPIGRLLFREFCATR-PELSRCVAFLDGVAEYEVTPDDKRKAC-GRQLTQNFLSHTGPDL 117
Query: 121 SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV 180
+Q V + L + LFQ E L F +++S F RF QWK +
Sbjct: 118 IPEVPRQLVTNCTQRLEQGPCKD-LFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWL 176
Query: 181 ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240
E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++GE +ALNE+
Sbjct: 177 ERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEK 235
Query: 241 IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLH---YHLSQHGVFSEKEMRFY 297
+L V++ F+V + YA+ T D LC +L LMNGGDL YH+ Q G F E FY
Sbjct: 236 QILEKVNS---RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG-FPEARAVFY 291
Query: 298 ATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKP-HASVGTHGY 356
A EI GLE +H +VYRDLKP NILLD+HGH RISDLGLA + + VGT GY
Sbjct: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGY 351
Query: 357 MAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTVNVELPD 415
MAPEV+ K Y S DW++LGC+L++++ G SPF+Q K K K E++R+ V E +
Sbjct: 352 MAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410
Query: 416 TFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRG 475
FSP+ +SL LL +D ++RLGC GG ++EVKEH FK ++++ + PP P
Sbjct: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQ 470
Query: 476 EVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQEVTET 524
+ D DI F KG++L DQ+ Y+ F + WQ E+ ET
Sbjct: 471 AIYCKDVLDIEQF--STVKGVELEPTDQDFYQKFATGSVPIPWQNEMVET 518
>gi|51896039 G protein-coupled receptor kinase 6 isoform A [Homo
sapiens]
Length = 576
Score = 317 bits (813), Expect = 2e-86
Identities = 206/530 (38%), Positives = 292/530 (55%), Gaps = 21/530 (3%)
Query: 3 DLEAVLADVSYLMAMEKSKATPAARASK-RIVLPEPSIRSVMQKYLA-ERNEITFDKIFN 60
+LE ++A+ L A E ++ K R +L P I + L+ ER+ + +
Sbjct: 2 ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCE--R 59
Query: 61 QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC 120
Q IG LLF++FC E V F + + EYE +++ + C RQ+ ++
Sbjct: 60 QPIGRLLFREFCATR-PELSRCVAFLDGVAEYEVTPDDKRKAC-GRQLTQNFLSHTGPDL 117
Query: 121 SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV 180
+Q V + L + LFQ E L F +++S F RF QWK +
Sbjct: 118 IPEVPRQLVTNCTQRLEQGPCKD-LFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWL 176
Query: 181 ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240
E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++GE +ALNE+
Sbjct: 177 ERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEK 235
Query: 241 IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLH---YHLSQHGVFSEKEMRFY 297
+L V++ F+V + YA+ T D LC +L LMNGGDL YH+ Q G F E FY
Sbjct: 236 QILEKVNS---RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG-FPEARAVFY 291
Query: 298 ATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKP-HASVGTHGY 356
A EI GLE +H +VYRDLKP NILLD+HGH RISDLGLA + + VGT GY
Sbjct: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGY 351
Query: 357 MAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTVNVELPD 415
MAPEV+ K Y S DW++LGC+L++++ G SPF+Q K K K E++R+ V E +
Sbjct: 352 MAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410
Query: 416 TFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRG 475
FSP+ +SL LL +D ++RLGC GG ++EVKEH FK ++++ + PP P
Sbjct: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQ 470
Query: 476 EVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQEVTET 524
+ D DI F KG++L DQ+ Y+ F + WQ E+ ET
Sbjct: 471 AIYCKDVLDIEQF--STVKGVELEPTDQDFYQKFATGSVPIPWQNEMVET 518
>gi|51896035 G protein-coupled receptor kinase 6 isoform B [Homo
sapiens]
Length = 589
Score = 317 bits (813), Expect = 2e-86
Identities = 206/530 (38%), Positives = 292/530 (55%), Gaps = 21/530 (3%)
Query: 3 DLEAVLADVSYLMAMEKSKATPAARASK-RIVLPEPSIRSVMQKYLA-ERNEITFDKIFN 60
+LE ++A+ L A E ++ K R +L P I + L+ ER+ + +
Sbjct: 2 ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCE--R 59
Query: 61 QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC 120
Q IG LLF++FC E V F + + EYE +++ + C RQ+ ++
Sbjct: 60 QPIGRLLFREFCATR-PELSRCVAFLDGVAEYEVTPDDKRKAC-GRQLTQNFLSHTGPDL 117
Query: 121 SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV 180
+Q V + L + LFQ E L F +++S F RF QWK +
Sbjct: 118 IPEVPRQLVTNCTQRLEQGPCKD-LFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWL 176
Query: 181 ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240
E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++GE +ALNE+
Sbjct: 177 ERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEK 235
Query: 241 IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLH---YHLSQHGVFSEKEMRFY 297
+L V++ F+V + YA+ T D LC +L LMNGGDL YH+ Q G F E FY
Sbjct: 236 QILEKVNS---RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG-FPEARAVFY 291
Query: 298 ATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKP-HASVGTHGY 356
A EI GLE +H +VYRDLKP NILLD+HGH RISDLGLA + + VGT GY
Sbjct: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGY 351
Query: 357 MAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTVNVELPD 415
MAPEV+ K Y S DW++LGC+L++++ G SPF+Q K K K E++R+ V E +
Sbjct: 352 MAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410
Query: 416 TFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRG 475
FSP+ +SL LL +D ++RLGC GG ++EVKEH FK ++++ + PP P
Sbjct: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQ 470
Query: 476 EVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQEVTET 524
+ D DI F KG++L DQ+ Y+ F + WQ E+ ET
Sbjct: 471 AIYCKDVLDIEQF--STVKGVELEPTDQDFYQKFATGSVPIPWQNEMVET 518
>gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [Homo
sapiens]
Length = 578
Score = 311 bits (796), Expect = 2e-84
Identities = 193/530 (36%), Positives = 287/530 (54%), Gaps = 20/530 (3%)
Query: 3 DLEAVLADVSYLMAMEKSKATPAARASKR---IVLPEPSIRSVMQKYLAERNEITFDKIF 59
+LE ++A+ L A + + R+ K + LP S S ++ + + DK
Sbjct: 2 ELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDK-- 59
Query: 60 NQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLS 119
Q IG LF+ FC + ++F + + EYE D+E+ C I D + +L +
Sbjct: 60 -QPIGRRLFRQFCDTKPT-LKRHIEFLDAVAEYEVADDEDRSDC-GLSILDRFFNDKLAA 116
Query: 120 CSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKN 179
V + L ++ + F+ LRG+ F+++ ES F++F QWK
Sbjct: 117 PLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKW 176
Query: 180 VELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 239
+E +T N F +R++G+GGFGEV C+ TGKMYA K L KKRIK ++GE +ALNE
Sbjct: 177 LERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNE 235
Query: 240 RIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHG--VFSEKEMRFY 297
+ +L V + F+V + YA+ T D LC +L +MNGGDL +H+ G F E+ FY
Sbjct: 236 KRILEKVQS---RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFY 292
Query: 298 ATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSK-KKPHASVGTHGY 356
A E+ GLE + +VYRDLKP NILLD+ GH RISDLGLA + + ++ VGT GY
Sbjct: 293 AAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGY 352
Query: 357 MAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTVNVELPD 415
MAPEV+ Y S DW+ LGC+++++++GHSPF+++K K K E+D+ E +
Sbjct: 353 MAPEVV-NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSE 411
Query: 416 TFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRG 475
FS + KS+ LL ++ SKRLGC G G+ VK+H FK ++++ + PP P
Sbjct: 412 KFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPH 471
Query: 476 EVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQEVTET 524
V D DI F KGI L D++ Y F +S WQ E+ E+
Sbjct: 472 AVYCKDVLDIEQFSV--VKGIYLDTADEDFYARFATGCVSIPWQNEMIES 519
>gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [Homo
sapiens]
Length = 532
Score = 308 bits (790), Expect = 8e-84
Identities = 192/526 (36%), Positives = 284/526 (53%), Gaps = 20/526 (3%)
Query: 3 DLEAVLADVSYLMAMEKSKATPAARASKR---IVLPEPSIRSVMQKYLAERNEITFDKIF 59
+LE ++A+ L A + + R+ K + LP S S ++ + + DK
Sbjct: 2 ELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDK-- 59
Query: 60 NQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLS 119
Q IG LF+ FC + ++F + + EYE D+E+ C I D + +L +
Sbjct: 60 -QPIGRRLFRQFCDTKPT-LKRHIEFLDAVAEYEVADDEDRSDC-GLSILDRFFNDKLAA 116
Query: 120 CSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKN 179
V + L ++ + F+ LRG+ F+++ ES F++F QWK
Sbjct: 117 PLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKW 176
Query: 180 VELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 239
+E +T N F +R++G+GGFGEV C+ TGKMYA K L KKRIK ++GE +ALNE
Sbjct: 177 LERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNE 235
Query: 240 RIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHG--VFSEKEMRFY 297
+ +L V + F+V + YA+ T D LC +L +MNGGDL +H+ G F E+ FY
Sbjct: 236 KRILEKVQS---RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFY 292
Query: 298 ATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSK-KKPHASVGTHGY 356
A E+ GLE + +VYRDLKP NILLD+ GH RISDLGLA + + ++ VGT GY
Sbjct: 293 AAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGY 352
Query: 357 MAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTVNVELPD 415
MAPEV+ Y S DW+ LGC+++++++GHSPF+++K K K E+D+ E +
Sbjct: 353 MAPEVV-NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSE 411
Query: 416 TFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRG 475
FS + KS+ LL ++ SKRLGC G G+ VK+H FK ++++ + PP P
Sbjct: 412 KFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPH 471
Query: 476 EVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQE 520
V D DI F KGI L D++ Y F +S WQ E
Sbjct: 472 AVYCKDVLDIEQFSV--VKGIYLDTADEDFYARFATGCVSIPWQNE 515
>gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Homo
sapiens]
Length = 546
Score = 307 bits (786), Expect = 2e-83
Identities = 180/469 (38%), Positives = 262/469 (55%), Gaps = 14/469 (2%)
Query: 61 QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC 120
Q IG LF+ FC + ++F + + EYE D+E+ C I D + +L +
Sbjct: 28 QPIGRRLFRQFCDTKPT-LKRHIEFLDAVAEYEVADDEDRSDC-GLSILDRFFNDKLAAP 85
Query: 121 SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV 180
V + L ++ + F+ LRG+ F+++ ES F++F QWK +
Sbjct: 86 LPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWL 145
Query: 181 ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240
E +T N F +R++G+GGFGEV C+ TGKMYA K L KKRIK ++GE +ALNE+
Sbjct: 146 ERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEK 204
Query: 241 IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHG--VFSEKEMRFYA 298
+L V + F+V + YA+ T D LC +L +MNGGDL +H+ G F E+ FYA
Sbjct: 205 RILEKVQS---RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYA 261
Query: 299 TEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSK-KKPHASVGTHGYM 357
E+ GLE + +VYRDLKP NILLD+ GH RISDLGLA + + ++ VGT GYM
Sbjct: 262 AELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYM 321
Query: 358 APEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTVNVELPDT 416
APEV+ Y S DW+ LGC+++++++GHSPF+++K K K E+D+ E +
Sbjct: 322 APEVV-NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEK 380
Query: 417 FSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGE 476
FS + KS+ LL ++ SKRLGC G G+ VK+H FK ++++ + PP P
Sbjct: 381 FSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHA 440
Query: 477 VNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQEVTET 524
V D DI F KGI L D++ Y F +S WQ E+ E+
Sbjct: 441 VYCKDVLDIEQFSV--VKGIYLDTADEDFYARFATGCVSIPWQNEMIES 487
>gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens]
Length = 590
Score = 306 bits (783), Expect = 5e-83
Identities = 199/537 (37%), Positives = 285/537 (53%), Gaps = 35/537 (6%)
Query: 3 DLEAVLADVSYLMAMEKSKATPAARASK-RIVLPEPSIRSVMQKYLAERNEITFDKIF-- 59
+LE ++A+ L A E ++ K + +L P I E T D+ +
Sbjct: 2 ELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQ------CEDLRRTIDRDYCS 55
Query: 60 ---NQKIGFLLFKDFCLNEINEAVP----QVKFYEEIKEYEKLDNEEDRLCRSRQIYDAY 112
Q IG LLF+ FC E P ++F + + EYE +E+ + ++I Y
Sbjct: 56 LCDKQPIGRLLFRQFC-----ETRPGLECYIQFLDSVAEYEVTPDEKLGE-KGKEIMTKY 109
Query: 113 IMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFT 172
+ + + V + L +K LF + + E LRG+ F ++++S F
Sbjct: 110 LTPKSPVFIAQVGQDLVSQTEEKLLQKPCKE-LFSACAQSVHEYLRGEPFHEYLDSMFFD 168
Query: 173 RFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQG 232
RF QWK +E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++G
Sbjct: 169 RFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKG 227
Query: 233 ETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHG--VFS 290
E++ALNE+ +L V++ F+V + YA+ T D LC +L +MNGGDL +H+ G F
Sbjct: 228 ESMALNEKQILEKVNS---QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFE 284
Query: 291 EKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSK-KKPHA 349
E+ FYA EI+ GLE +H VYRDLKP NILLD++GH RISDLGLA +
Sbjct: 285 EERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRG 344
Query: 350 SVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLT 408
VGT GYMAPEVL Y S D++ LGC++++++ G SPFR K K K E+DR L
Sbjct: 345 RVGTVGYMAPEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLE 403
Query: 409 VNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPP 468
FS E KS+ + LL +D +RLGC G+ EVK H FF+ ++++ + P
Sbjct: 404 TEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDP 463
Query: 469 PLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQEVTET 524
P +P V D DI F KG+ L D + Y F +S WQ E+ ET
Sbjct: 464 PFVPDPRAVYCKDVLDIEQF--STVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIET 518
>gi|4506529 rhodopsin kinase [Homo sapiens]
Length = 563
Score = 269 bits (688), Expect = 6e-72
Identities = 181/536 (33%), Positives = 280/536 (52%), Gaps = 31/536 (5%)
Query: 4 LEAVLADVSYLMA---MEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKI-F 59
LE V+A+ +++ A + S + P+ L P + + L + + F+ +
Sbjct: 6 LETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKC--ESLRDSLSLEFESVCL 63
Query: 60 NQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKEL-L 118
Q IG LF+ F L + +P ++ +++I++Y+ DN+ +++ I Y+ + L
Sbjct: 64 EQPIGKKLFQQF-LQSAEKHLPALELWKDIEDYDTADNDLQPQ-KAQTILAQYLDPQAKL 121
Query: 119 SCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWK 178
CS + + + ++ LFQP ++ L FQ+++ S F RF QWK
Sbjct: 122 FCSFLDEGIVAKFKEGPV---EIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWK 178
Query: 179 NVELNIHLTMNE--FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLA 236
+E M E F R++G+GGFGEV C+ TGK+YA K L+KKR+K ++G A
Sbjct: 179 WLEAQ---PMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGA 235
Query: 237 LNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHL----SQHGVFSEK 292
+ E+ +L V + FIV + YAF T LC ++ +MNGGD+ YH+ ++ F E
Sbjct: 236 MVEKKILMKVHSR---FIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEP 292
Query: 293 EMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDF--SKKKPHAS 350
FY +II GLEH+H R +VYRDLKP N+LLD G+ RISDLGLA + + K
Sbjct: 293 RALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGY 352
Query: 351 VGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK-DKHEIDRMTLTV 409
GT G+MAPE+LQ G YD S D+F+LG L++++ PFR K + E+ ++
Sbjct: 353 AGTPGFMAPELLQ-GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISE 411
Query: 410 NVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPP 469
V+ PD FS K E LL++D KRLG +++ H FK ++W+ + PP
Sbjct: 412 PVKYPDKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPP 471
Query: 470 LIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQEVTET 524
IP V A D D+G+F KG+ D E ++ F WQ+E+ ET
Sbjct: 472 FIPDSKTVYAKDIQDVGAF--STVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIET 525
>gi|21166359 G-protein-coupled receptor kinase 7 [Homo sapiens]
Length = 553
Score = 268 bits (685), Expect = 1e-71
Identities = 172/538 (31%), Positives = 280/538 (52%), Gaps = 18/538 (3%)
Query: 1 MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN 60
M L+ ++A+ +YL A + S +R L P ++ + L ++ + F +
Sbjct: 4 MGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAE--LRQKLSLNFHSLCE 61
Query: 61 QK-IGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLS 119
Q+ IG LF+DF L + F E+++ +E + + + +
Sbjct: 62 QQPIGRRLFRDF-LATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPG 120
Query: 120 CSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKN 179
PF QAV + ++ E L+ F+ F+ S + +F QWK
Sbjct: 121 NPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKL 180
Query: 180 VELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 239
E+ ++ F+ R++G+GGFGEV + +TGKMYA K LDKKR+K K GE +AL E
Sbjct: 181 FEMQ-PVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLE 239
Query: 240 RIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV--FSEKEMRFY 297
+ +L VS+ PFIV + YAF + LC ++ LMNGGDL +H+ G + FY
Sbjct: 240 KEILEKVSS---PFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFY 296
Query: 298 ATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHAS-VGTHGY 356
+ +I G+ H+H +VYRD+KP N+LLD+ G+ R+SDLGLA + KP GT+GY
Sbjct: 297 SAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGY 356
Query: 357 MAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK-DKHEIDRMTLTVNVELP- 414
MAPE+L + +Y DWF++GC +++++ G +PF+ +K K K ++ + TL V+
Sbjct: 357 MAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQH 416
Query: 415 DTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPR 474
D F+ E K + L + +RLG S + ++H FFK +++ + PP +P
Sbjct: 417 DNFTEEAKDICRLFLAKKPEQRLGSR-EKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDP 475
Query: 475 GEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQEVTET-VYEAVN 530
V A D +I F E +G++ D D++ +KNF + WQ+E+ ET ++E +N
Sbjct: 476 SVVYAKDIAEIDDFSE--VRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELN 531
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 217 bits (552), Expect = 3e-56
Identities = 124/345 (35%), Positives = 200/345 (57%), Gaps = 16/345 (4%)
Query: 189 NEFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245
++F + +++G+G FG+V+ +K +D ++YAMK L K +K++ + I++ +
Sbjct: 66 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEV 125
Query: 246 VSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGL 305
+ PFIV + YAF T KL ILD + GGDL LS+ +F+E++++FY E+ L L
Sbjct: 126 ----NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAL 181
Query: 306 EHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDF--SKKKPHASVGTHGYMAPEVLQ 363
+H+H+ ++YRDLKP NILLDE GH +++D GL+ + +KK ++ GT YMAPEV+
Sbjct: 182 DHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVN 241
Query: 364 KGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKS 423
+ + SADW+S G ++F++L G PF + KD+ E M L + +P SPE +S
Sbjct: 242 R-RGHTQSADWWSFGVLMFEMLTGTLPF---QGKDRKETMTMILKAKLGMPQFLSPEAQS 297
Query: 424 LLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAF 483
LL L +R+ + RLG G +E+K HSFF +DW +Y ++ PP P G F
Sbjct: 298 LLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYF 357
Query: 484 D--IGSFDEEDTKGIKLLDCDQELYKNFPLV-ISERWQQEVTETV 525
D + +D+ GI +L++ F V I+ + + +TV
Sbjct: 358 DPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTV 402
Score = 83.2 bits (204), Expect = 7e-16
Identities = 71/223 (31%), Positives = 108/223 (48%), Gaps = 26/223 (11%)
Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250
+ V IG G + C T +A+K +DK K+ T E I + L+ G
Sbjct: 422 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKS----KRDPT----EEIEI-LLRYGQ 472
Query: 251 CPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHN 310
P I+ + + + + +LM GG+L + + FSE+E I +E++H
Sbjct: 473 HPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHA 532
Query: 311 RFVVYRDLKPANIL-LDEHGH---ARISDLGLACDFSKKKPHASVG-------THGYMAP 359
+ VV+RDLKP+NIL +DE G+ RI D G A K+ A G T ++AP
Sbjct: 533 QGVVHRDLKPSNILYVDESGNPESIRICDFGFA-----KQLRAENGLLMTPCYTANFVAP 587
Query: 360 EVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEI 402
EVL K YD++ D +SLG +L+ +L G++PF EI
Sbjct: 588 EVL-KRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEI 629
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 216 bits (550), Expect = 6e-56
Identities = 122/317 (38%), Positives = 182/317 (57%), Gaps = 15/317 (4%)
Query: 186 LTMNEFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMK-QGETLALNERI 241
+++ F + +++G G +G+V+ RKA D GK+YAMK L K + + + + ER
Sbjct: 28 VSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERS 87
Query: 242 MLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEI 301
+L LV PF+V + YAF T KL ILD ++GG++ HL Q F E E+R Y EI
Sbjct: 88 VLELVR--QAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEI 145
Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDF---SKKKPHASVGTHGYMA 358
+L LEH+H ++YRDLK N+LLD GH ++D GL+ +F K++ + GT YMA
Sbjct: 146 VLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMA 205
Query: 359 PEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFR-QHKTKDKHEIDRMTLTVNVELPDTF 417
PE+++ T + + DW+SLG +LF+LL G SPF + + + E+ R L + P
Sbjct: 206 PEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRI 265
Query: 418 SPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEV 477
P + LL+ LL +D KRLG G+QEV+ H FF+G+DW + +K P P P
Sbjct: 266 GPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRP----- 320
Query: 478 NAADAFDIGSFDEEDTK 494
D+G+F EE T+
Sbjct: 321 QIRSELDVGNFAEEFTR 337
Score = 86.7 bits (213), Expect = 7e-17
Identities = 83/296 (28%), Positives = 127/296 (42%), Gaps = 43/296 (14%)
Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256
+G+G F CR+ +G+ +A+K L ++ Q E AL R+ S P +V
Sbjct: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAAL--RLCQSH------PNVVN 462
Query: 257 MTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRF-VVY 315
+ H +L+L+ GG+L H+ + FSE E ++ + MH VV+
Sbjct: 463 LHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVH 522
Query: 316 RDLKPANILLDEH---GHARISDLGLACDFSKKKPHAS-------VGTHGYMAPEVLQKG 365
RDLKP NIL + +I D G F++ +P + T Y APE+L +
Sbjct: 523 RDLKPENILYADDTPGAPVKIIDFG----FARLRPQSPGVPMQTPCFTLQYAAPELLAQ- 577
Query: 366 TAYDSSADWFSLGCMLFKLLRGHSPF--------RQHKTKDKHEIDRMTLTVNVELPDTF 417
YD S D +SLG +L+ +L G PF + + +I +++ E
Sbjct: 578 QGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGV 637
Query: 418 SPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPP 473
S E K L+ GLL D +KRL G +G W + PPL P
Sbjct: 638 SEEAKELVRGLLTVDPAKRLKLEG-----------LRGSSWLQDGSARSSPPLRTP 682
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 216 bits (550), Expect = 6e-56
Identities = 122/317 (38%), Positives = 182/317 (57%), Gaps = 15/317 (4%)
Query: 186 LTMNEFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMK-QGETLALNERI 241
+++ F + +++G G +G+V+ RKA D GK+YAMK L K + + + + ER
Sbjct: 28 VSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERS 87
Query: 242 MLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEI 301
+L LV PF+V + YAF T KL ILD ++GG++ HL Q F E E+R Y EI
Sbjct: 88 VLELVR--QAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEI 145
Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDF---SKKKPHASVGTHGYMA 358
+L LEH+H ++YRDLK N+LLD GH ++D GL+ +F K++ + GT YMA
Sbjct: 146 VLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMA 205
Query: 359 PEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFR-QHKTKDKHEIDRMTLTVNVELPDTF 417
PE+++ T + + DW+SLG +LF+LL G SPF + + + E+ R L + P
Sbjct: 206 PEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRI 265
Query: 418 SPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEV 477
P + LL+ LL +D KRLG G+QEV+ H FF+G+DW + +K P P P
Sbjct: 266 GPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRP----- 320
Query: 478 NAADAFDIGSFDEEDTK 494
D+G+F EE T+
Sbjct: 321 QIRSELDVGNFAEEFTR 337
Score = 86.7 bits (213), Expect = 7e-17
Identities = 83/296 (28%), Positives = 127/296 (42%), Gaps = 43/296 (14%)
Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256
+G+G F CR+ +G+ +A+K L ++ Q E AL R+ S P +V
Sbjct: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAAL--RLCQSH------PNVVN 468
Query: 257 MTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRF-VVY 315
+ H +L+L+ GG+L H+ + FSE E ++ + MH VV+
Sbjct: 469 LHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVH 528
Query: 316 RDLKPANILLDEH---GHARISDLGLACDFSKKKPHAS-------VGTHGYMAPEVLQKG 365
RDLKP NIL + +I D G F++ +P + T Y APE+L +
Sbjct: 529 RDLKPENILYADDTPGAPVKIIDFG----FARLRPQSPGVPMQTPCFTLQYAAPELLAQ- 583
Query: 366 TAYDSSADWFSLGCMLFKLLRGHSPF--------RQHKTKDKHEIDRMTLTVNVELPDTF 417
YD S D +SLG +L+ +L G PF + + +I +++ E
Sbjct: 584 QGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGV 643
Query: 418 SPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPP 473
S E K L+ GLL D +KRL G +G W + PPL P
Sbjct: 644 SEEAKELVRGLLTVDPAKRLKLEG-----------LRGSSWLQDGSARSSPPLRTP 688
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 215 bits (548), Expect = 1e-55
Identities = 120/311 (38%), Positives = 177/311 (56%), Gaps = 15/311 (4%)
Query: 186 LTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245
+TMNEF +++G+G FG+V ++ TG+ YAMK L K+ I K L E +L
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ- 203
Query: 246 VSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGL 305
PF+ + Y+F T D+LCF+++ NGG+L +HLS+ VFSE RFY EI+ L
Sbjct: 204 --NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
Query: 306 EHMHN-RFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASV--GTHGYMAPEVL 362
+++H+ + VVYRDLK N++LD+ GH +I+D GL + K GT Y+APEVL
Sbjct: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321
Query: 363 QKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELK 422
+ Y + DW+ LG ++++++ G PF +D ++ + L + P T PE K
Sbjct: 322 EDND-YGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEEIRFPRTLGPEAK 377
Query: 423 SLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADA 482
SLL GLL++D +RLG ++E+ +H FF G+ WQHVY +K PP P
Sbjct: 378 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP-----QVTSE 432
Query: 483 FDIGSFDEEDT 493
D FDEE T
Sbjct: 433 TDTRYFDEEFT 443
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 215 bits (548), Expect = 1e-55
Identities = 120/311 (38%), Positives = 177/311 (56%), Gaps = 15/311 (4%)
Query: 186 LTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245
+TMNEF +++G+G FG+V ++ TG+ YAMK L K+ I K L E +L
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ- 203
Query: 246 VSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGL 305
PF+ + Y+F T D+LCF+++ NGG+L +HLS+ VFSE RFY EI+ L
Sbjct: 204 --NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
Query: 306 EHMHN-RFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASV--GTHGYMAPEVL 362
+++H+ + VVYRDLK N++LD+ GH +I+D GL + K GT Y+APEVL
Sbjct: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321
Query: 363 QKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELK 422
+ Y + DW+ LG ++++++ G PF +D ++ + L + P T PE K
Sbjct: 322 EDND-YGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEEIRFPRTLGPEAK 377
Query: 423 SLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADA 482
SLL GLL++D +RLG ++E+ +H FF G+ WQHVY +K PP P
Sbjct: 378 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP-----QVTSE 432
Query: 483 FDIGSFDEEDT 493
D FDEE T
Sbjct: 433 TDTRYFDEEFT 443
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 215 bits (548), Expect = 1e-55
Identities = 120/311 (38%), Positives = 177/311 (56%), Gaps = 15/311 (4%)
Query: 186 LTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245
+TMNEF +++G+G FG+V ++ TG+ YAMK L K+ I K L E +L
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ- 203
Query: 246 VSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGL 305
PF+ + Y+F T D+LCF+++ NGG+L +HLS+ VFSE RFY EI+ L
Sbjct: 204 --NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
Query: 306 EHMHN-RFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASV--GTHGYMAPEVL 362
+++H+ + VVYRDLK N++LD+ GH +I+D GL + K GT Y+APEVL
Sbjct: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321
Query: 363 QKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELK 422
+ Y + DW+ LG ++++++ G PF +D ++ + L + P T PE K
Sbjct: 322 EDND-YGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEEIRFPRTLGPEAK 377
Query: 423 SLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADA 482
SLL GLL++D +RLG ++E+ +H FF G+ WQHVY +K PP P
Sbjct: 378 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP-----QVTSE 432
Query: 483 FDIGSFDEEDT 493
D FDEE T
Sbjct: 433 TDTRYFDEEFT 443
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 214 bits (545), Expect = 2e-55
Identities = 119/331 (35%), Positives = 192/331 (58%), Gaps = 15/331 (4%)
Query: 189 NEFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245
+ F + +++G+G FG+V+ RK D+G +YAMK L K +K++ + I+ +
Sbjct: 69 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADV 128
Query: 246 VSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGL 305
+ PF+V + YAF T KL ILD + GGDL LS+ +F+E++++FY E+ LGL
Sbjct: 129 ----NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGL 184
Query: 306 EHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDF--SKKKPHASVGTHGYMAPEVLQ 363
+H+H+ ++YRDLKP NILLDE GH +++D GL+ + +KK ++ GT YMAPEV+
Sbjct: 185 DHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVN 244
Query: 364 KGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKS 423
+ + SADW+S G ++F++L G PF + KD+ E + L + +P S E +S
Sbjct: 245 R-QGHSHSADWWSYGVLMFEMLTGSLPF---QGKDRKETMTLILKAKLGMPQFLSTEAQS 300
Query: 424 LLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAF 483
LL L +R+ + RLG G++E+K H F+ +DW +Y ++ PP P + + F
Sbjct: 301 LLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYF 360
Query: 484 D--IGSFDEEDTKGIKLLDCDQELYKNFPLV 512
D S +D+ GI +L++ F V
Sbjct: 361 DTEFTSRTPKDSPGIPPSAGAHQLFRGFSFV 391
Score = 93.6 bits (231), Expect = 5e-19
Identities = 81/262 (30%), Positives = 123/262 (46%), Gaps = 30/262 (11%)
Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250
+ V IG G + E C T YA+K +DK K E + + L+ G
Sbjct: 427 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS--KRDPSEEIEI-------LLRYGQ 477
Query: 251 CPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHN 310
P I+ + + + + +LM GG+L + + FSE+E F I +E++H+
Sbjct: 478 HPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHS 537
Query: 311 RFVVYRDLKPANIL-LDEHGH---ARISDLGLACDFSKKKPHASVG-------THGYMAP 359
+ VV+RDLKP+NIL +DE G+ RI D G A K+ A G T ++AP
Sbjct: 538 QGVVHRDLKPSNILYVDESGNPECLRICDFGFA-----KQLRAENGLLMTPCYTANFVAP 592
Query: 360 EVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE----IDRMTLTVNVELPD 415
EVL K YD D +SLG +L+ +L G++PF + E I T++ +
Sbjct: 593 EVL-KRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 651
Query: 416 TFSPELKSLLEGLLQRDVSKRL 437
T S K L+ +L D +RL
Sbjct: 652 TVSETAKDLVSKMLHVDPHQRL 673
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 214 bits (545), Expect = 2e-55
Identities = 119/331 (35%), Positives = 192/331 (58%), Gaps = 15/331 (4%)
Query: 189 NEFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245
+ F + +++G+G FG+V+ RK D+G +YAMK L K +K++ + I+ +
Sbjct: 60 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADV 119
Query: 246 VSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGL 305
+ PF+V + YAF T KL ILD + GGDL LS+ +F+E++++FY E+ LGL
Sbjct: 120 ----NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGL 175
Query: 306 EHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDF--SKKKPHASVGTHGYMAPEVLQ 363
+H+H+ ++YRDLKP NILLDE GH +++D GL+ + +KK ++ GT YMAPEV+
Sbjct: 176 DHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVN 235
Query: 364 KGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKS 423
+ + SADW+S G ++F++L G PF + KD+ E + L + +P S E +S
Sbjct: 236 R-QGHSHSADWWSYGVLMFEMLTGSLPF---QGKDRKETMTLILKAKLGMPQFLSTEAQS 291
Query: 424 LLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAF 483
LL L +R+ + RLG G++E+K H F+ +DW +Y ++ PP P + + F
Sbjct: 292 LLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYF 351
Query: 484 D--IGSFDEEDTKGIKLLDCDQELYKNFPLV 512
D S +D+ GI +L++ F V
Sbjct: 352 DTEFTSRTPKDSPGIPPSAGAHQLFRGFSFV 382
Score = 93.6 bits (231), Expect = 5e-19
Identities = 81/262 (30%), Positives = 123/262 (46%), Gaps = 30/262 (11%)
Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250
+ V IG G + E C T YA+K +DK K E + + L+ G
Sbjct: 418 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS--KRDPSEEIEI-------LLRYGQ 468
Query: 251 CPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHN 310
P I+ + + + + +LM GG+L + + FSE+E F I +E++H+
Sbjct: 469 HPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHS 528
Query: 311 RFVVYRDLKPANIL-LDEHGH---ARISDLGLACDFSKKKPHASVG-------THGYMAP 359
+ VV+RDLKP+NIL +DE G+ RI D G A K+ A G T ++AP
Sbjct: 529 QGVVHRDLKPSNILYVDESGNPECLRICDFGFA-----KQLRAENGLLMTPCYTANFVAP 583
Query: 360 EVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE----IDRMTLTVNVELPD 415
EVL K YD D +SLG +L+ +L G++PF + E I T++ +
Sbjct: 584 EVL-KRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 642
Query: 416 TFSPELKSLLEGLLQRDVSKRL 437
T S K L+ +L D +RL
Sbjct: 643 TVSETAKDLVSKMLHVDPHQRL 664
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 213 bits (543), Expect = 4e-55
Identities = 121/311 (38%), Positives = 179/311 (57%), Gaps = 18/311 (5%)
Query: 187 TMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246
TMN+F +++G+G FG+V R+ +GK YAMK L K+ I K L E +L
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT 203
Query: 247 STGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLE 306
PF+ + Y+F T D+LCF+++ +NGG+L +HLS+ VFSE RFY EI+ L+
Sbjct: 204 RH---PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALD 260
Query: 307 HMHNRFVVYRDLKPANILLDEHGHARISDLGLA----CDFSKKKPHASVGTHGYMAPEVL 362
++H+ +VYRDLK N++LD+ GH +I+D GL D + K GT Y+APEVL
Sbjct: 261 YLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFC--GTPEYLAPEVL 318
Query: 363 QKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELK 422
+ Y + DW+ LG ++++++ G PF +D ++ + L +++ P T S + K
Sbjct: 319 EDND-YGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEDIKFPRTLSSDAK 374
Query: 423 SLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADA 482
SLL GLL +D +KRLG ++E+ HSFF GV+WQ VY +K PP P
Sbjct: 375 SLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP-----QVTSE 429
Query: 483 FDIGSFDEEDT 493
D FDEE T
Sbjct: 430 TDTRYFDEEFT 440
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 213 bits (543), Expect = 4e-55
Identities = 121/311 (38%), Positives = 179/311 (57%), Gaps = 18/311 (5%)
Query: 187 TMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246
TMN+F +++G+G FG+V R+ +GK YAMK L K+ I K L E +L
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT 203
Query: 247 STGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLE 306
PF+ + Y+F T D+LCF+++ +NGG+L +HLS+ VFSE RFY EI+ L+
Sbjct: 204 RH---PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALD 260
Query: 307 HMHNRFVVYRDLKPANILLDEHGHARISDLGLA----CDFSKKKPHASVGTHGYMAPEVL 362
++H+ +VYRDLK N++LD+ GH +I+D GL D + K GT Y+APEVL
Sbjct: 261 YLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFC--GTPEYLAPEVL 318
Query: 363 QKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELK 422
+ Y + DW+ LG ++++++ G PF +D ++ + L +++ P T S + K
Sbjct: 319 EDND-YGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEDIKFPRTLSSDAK 374
Query: 423 SLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADA 482
SLL GLL +D +KRLG ++E+ HSFF GV+WQ VY +K PP P
Sbjct: 375 SLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP-----QVTSE 429
Query: 483 FDIGSFDEEDT 493
D FDEE T
Sbjct: 430 TDTRYFDEEFT 440
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 213 bits (543), Expect = 4e-55
Identities = 121/330 (36%), Positives = 192/330 (58%), Gaps = 17/330 (5%)
Query: 190 EFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246
+F + +++G+G FG+V+ RK D G++YAMK L K +K++ + I++ +
Sbjct: 72 QFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEV- 130
Query: 247 STGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLE 306
+ PFIV + YAF T KL ILD + GGD+ LS+ +F+E++++FY E+ L L+
Sbjct: 131 ---NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALD 187
Query: 307 HMHNRFVVYRDLKPANILLDEHGHARISDLGLACDF--SKKKPHASVGTHGYMAPEVLQK 364
H+H +VYRDLKP NILLDE GH +++D GL+ + +KK ++ GT YMAPEV+ +
Sbjct: 188 HLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNR 247
Query: 365 GTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSL 424
+ SADW+S G ++F++L G PF + KD++E M L + +P S E +SL
Sbjct: 248 -RGHSQSADWWSYGVLMFEMLTGTLPF---QGKDRNETMNMILKAKLGMPQFLSAEAQSL 303
Query: 425 LEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFD 484
L L +R+ + RLG G +E+K H FF +DW +Y ++ PP P G+ + FD
Sbjct: 304 LRMLFKRNPANRLGSE--GVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFD 361
Query: 485 --IGSFDEEDTKGIKLLDCDQELYKNFPLV 512
+ +D+ G+ +L+K F V
Sbjct: 362 PEFTAKTPKDSPGLPASANAHQLFKGFSFV 391
Score = 82.8 bits (203), Expect = 1e-15
Identities = 76/266 (28%), Positives = 119/266 (44%), Gaps = 25/266 (9%)
Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256
IG G + C A T +A+K +DK K E + + L+ G P I+
Sbjct: 432 IGVGSYSVCKRCIHATTNMEFAVKIIDKS--KRDPSEEIEI-------LMRYGQHPNIIT 482
Query: 257 MTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYR 316
+ F + + DLM GG+L + + FSE+E I ++++H + VV+R
Sbjct: 483 LKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHR 542
Query: 317 DLKPANIL-LDEHGHA---RISDLGLACDFSKKKP--HASVGTHGYMAPEVLQKGTAYDS 370
DLKP+NIL +DE A RI D G A + T ++APEVL + YD+
Sbjct: 543 DLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQ-QGYDA 601
Query: 371 SADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELP----DTFSPELKSLLE 426
+ D +SLG + + +L G++PF EI L D S K LL
Sbjct: 602 ACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLS 661
Query: 427 GLLQRDVSKRLGCHGGGSQEVKEHSF 452
+L D +R ++++ +HS+
Sbjct: 662 HMLHMDPHQRY-----TAEQILKHSW 682
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 212 bits (539), Expect = 1e-54
Identities = 120/312 (38%), Positives = 177/312 (56%), Gaps = 18/312 (5%)
Query: 186 LTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245
+TMN+F +++G+G FG+V R+ TG+ YAMK L K+ I K + E +L
Sbjct: 147 VTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQN 206
Query: 246 VSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGL 305
PF+ + YAF T D+LCF+++ NGG+L +HLS+ VF+E+ RFY EI+ L
Sbjct: 207 TRH---PFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSAL 263
Query: 306 EHMHNRFVVYRDLKPANILLDEHGHARISDLGLA----CDFSKKKPHASVGTHGYMAPEV 361
E++H+R VVYRD+K N++LD+ GH +I+D GL D + K GT Y+APEV
Sbjct: 264 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFC--GTPEYLAPEV 321
Query: 362 LQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPEL 421
L+ Y + DW+ LG ++++++ G PF +D + + L + P T SPE
Sbjct: 322 LEDND-YGRAVDWWGLGVVMYEMMCGRLPF---YNQDHERLFELILMEEIRFPRTLSPEA 377
Query: 422 KSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAAD 481
KSLL GLL++D +RLG ++EV EH FF ++WQ V +K PP P
Sbjct: 378 KSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKP-----QVTS 432
Query: 482 AFDIGSFDEEDT 493
D FD+E T
Sbjct: 433 EVDTRYFDDEFT 444
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 210 bits (534), Expect = 4e-54
Identities = 122/316 (38%), Positives = 180/316 (56%), Gaps = 16/316 (5%)
Query: 188 MNEFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETL-ALNERIML 243
+ F + +++G G +G+V+ RK DTGK+YAMK L K I K T ER +L
Sbjct: 46 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 105
Query: 244 SLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIIL 303
+ PF+V + YAF T KL ILD +NGG+L HLSQ F+E E++ Y EI+L
Sbjct: 106 EHIRQS--PFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVL 163
Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDF---SKKKPHASVGTHGYMAPE 360
LEH+H ++YRD+K NILLD +GH ++D GL+ +F ++ ++ GT YMAP+
Sbjct: 164 ALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPD 223
Query: 361 VLQKG-TAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTVNVELPDTFS 418
+++ G + +D + DW+SLG ++++LL G SPF K+ EI R L P S
Sbjct: 224 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMS 283
Query: 419 PELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVN 478
K L++ LL +D KRLGC + E+KEH FF+ ++W + +K P P P
Sbjct: 284 ALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPV----- 338
Query: 479 AADAFDIGSFDEEDTK 494
D D+ +F EE T+
Sbjct: 339 IRDELDVSNFAEEFTE 354
Score = 56.2 bits (134), Expect = 1e-07
Identities = 36/124 (29%), Positives = 59/124 (47%), Gaps = 8/124 (6%)
Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256
+G G F C + + +A+K + K+ Q E AL + G P IV
Sbjct: 432 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALK-------LCEGH-PNIVK 483
Query: 257 MTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYR 316
+ FH +++L+NGG+L + + FSE E + +++ + HMH+ VV+R
Sbjct: 484 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543
Query: 317 DLKP 320
DLKP
Sbjct: 544 DLKP 547
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 210 bits (534), Expect = 4e-54
Identities = 122/316 (38%), Positives = 180/316 (56%), Gaps = 16/316 (5%)
Query: 188 MNEFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETL-ALNERIML 243
+ F + +++G G +G+V+ RK DTGK+YAMK L K I K T ER +L
Sbjct: 46 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 105
Query: 244 SLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIIL 303
+ PF+V + YAF T KL ILD +NGG+L HLSQ F+E E++ Y EI+L
Sbjct: 106 EHIRQS--PFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVL 163
Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDF---SKKKPHASVGTHGYMAPE 360
LEH+H ++YRD+K NILLD +GH ++D GL+ +F ++ ++ GT YMAP+
Sbjct: 164 ALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPD 223
Query: 361 VLQKG-TAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTVNVELPDTFS 418
+++ G + +D + DW+SLG ++++LL G SPF K+ EI R L P S
Sbjct: 224 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMS 283
Query: 419 PELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVN 478
K L++ LL +D KRLGC + E+KEH FF+ ++W + +K P P P
Sbjct: 284 ALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPV----- 338
Query: 479 AADAFDIGSFDEEDTK 494
D D+ +F EE T+
Sbjct: 339 IRDELDVSNFAEEFTE 354
Score = 97.8 bits (242), Expect = 3e-20
Identities = 77/260 (29%), Positives = 120/260 (46%), Gaps = 26/260 (10%)
Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256
+G G F C + + +A+K + K+ Q E AL + G P IV
Sbjct: 432 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALK-------LCEGH-PNIVK 483
Query: 257 MTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYR 316
+ FH +++L+NGG+L + + FSE E + +++ + HMH+ VV+R
Sbjct: 484 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543
Query: 317 DLKPANILL-DEHGHARISDLGLACDFSKKKP------HASVGTHGYMAPEVLQKGTAYD 369
DLKP N+L DE+ + I + F++ KP T Y APE+L + YD
Sbjct: 544 DLKPENLLFTDENDNLEIKIIDFG--FARLKPPDNQPLKTPCFTLHYAAPELLNQ-NGYD 600
Query: 370 SSADWFSLGCMLFKLLRGHSPFRQH--------KTKDKHEIDRMTLTVNVELPDTFSPEL 421
S D +SLG +L+ +L G PF+ H + +I + + E S E
Sbjct: 601 ESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEA 660
Query: 422 KSLLEGLLQRDVSKRLGCHG 441
K L++GLL D +KRL G
Sbjct: 661 KDLIQGLLTVDPNKRLKMSG 680
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 210 bits (534), Expect = 4e-54
Identities = 119/346 (34%), Positives = 196/346 (56%), Gaps = 15/346 (4%)
Query: 189 NEFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245
++F + +++G+G +G+V+ RK +D G++YAMK L K +K++ + ++ +
Sbjct: 65 SQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRD----RVRSKMERDI 120
Query: 246 VSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGL 305
++ + PFIV + YAF T KL ILD + GGDL LS+ +F+E++++FY E+ L L
Sbjct: 121 LAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAL 180
Query: 306 EHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDF--SKKKPHASVGTHGYMAPEVLQ 363
+H+H+ ++YRDLKP NILLDE GH +I+D GL+ + K+ ++ GT YMAPEV+
Sbjct: 181 DHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVN 240
Query: 364 KGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKS 423
+ + SADW+S G ++F++L G PF + KD+ E + L + +P S E +S
Sbjct: 241 R-RGHTQSADWWSFGVLMFEMLTGSLPF---QGKDRKETMALILKAKLGMPQFLSGEAQS 296
Query: 424 LLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAF 483
LL L +R+ RLG G +E+K H FF +DW +Y ++ PP P G F
Sbjct: 297 LLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHF 356
Query: 484 D--IGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYE 527
D + D+ G+ L++ F V S Q+ + +++
Sbjct: 357 DPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHK 402
Score = 88.2 bits (217), Expect = 2e-17
Identities = 79/270 (29%), Positives = 124/270 (45%), Gaps = 31/270 (11%)
Query: 183 NIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242
NIH T + + + IG G + C T YA+K +DK K E + +
Sbjct: 416 NIHFT-DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS--KRDPSEEIEI----- 467
Query: 243 LSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEII 302
L+ G P I+ + + + +++LM GG+L + + FSE+E I
Sbjct: 468 --LLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTIT 525
Query: 303 LGLEHMHNRFVVYRDLKPANILL-DEHG---HARISDLGLACDFSKKKPHASVG------ 352
++++H++ VV+RDLKP+NIL DE G R+ D G A K+ A G
Sbjct: 526 KTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFA-----KQLRAGNGLLMTPC 580
Query: 353 -THGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNV 411
T ++APEVL K YD++ D +SLG +L+ +L G +PF EI +
Sbjct: 581 YTANFVAPEVL-KRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKY 639
Query: 412 ELP----DTFSPELKSLLEGLLQRDVSKRL 437
L D+ S K ++ +L D +RL
Sbjct: 640 ALSGGNWDSISDAAKDVVSKMLHVDPHQRL 669
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 210 bits (534), Expect = 4e-54
Identities = 119/346 (34%), Positives = 196/346 (56%), Gaps = 15/346 (4%)
Query: 189 NEFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245
++F + +++G+G +G+V+ RK +D G++YAMK L K +K++ + ++ +
Sbjct: 57 SQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRD----RVRSKMERDI 112
Query: 246 VSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGL 305
++ + PFIV + YAF T KL ILD + GGDL LS+ +F+E++++FY E+ L L
Sbjct: 113 LAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAL 172
Query: 306 EHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDF--SKKKPHASVGTHGYMAPEVLQ 363
+H+H+ ++YRDLKP NILLDE GH +I+D GL+ + K+ ++ GT YMAPEV+
Sbjct: 173 DHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVN 232
Query: 364 KGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKS 423
+ + SADW+S G ++F++L G PF + KD+ E + L + +P S E +S
Sbjct: 233 R-RGHTQSADWWSFGVLMFEMLTGSLPF---QGKDRKETMALILKAKLGMPQFLSGEAQS 288
Query: 424 LLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAF 483
LL L +R+ RLG G +E+K H FF +DW +Y ++ PP P G F
Sbjct: 289 LLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHF 348
Query: 484 D--IGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYE 527
D + D+ G+ L++ F V S Q+ + +++
Sbjct: 349 DPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHK 394
Score = 88.2 bits (217), Expect = 2e-17
Identities = 79/270 (29%), Positives = 124/270 (45%), Gaps = 31/270 (11%)
Query: 183 NIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242
NIH T + + + IG G + C T YA+K +DK K E + +
Sbjct: 408 NIHFT-DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS--KRDPSEEIEI----- 459
Query: 243 LSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEII 302
L+ G P I+ + + + +++LM GG+L + + FSE+E I
Sbjct: 460 --LLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTIT 517
Query: 303 LGLEHMHNRFVVYRDLKPANILL-DEHG---HARISDLGLACDFSKKKPHASVG------ 352
++++H++ VV+RDLKP+NIL DE G R+ D G A K+ A G
Sbjct: 518 KTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFA-----KQLRAGNGLLMTPC 572
Query: 353 -THGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNV 411
T ++APEVL K YD++ D +SLG +L+ +L G +PF EI +
Sbjct: 573 YTANFVAPEVL-KRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKY 631
Query: 412 ELP----DTFSPELKSLLEGLLQRDVSKRL 437
L D+ S K ++ +L D +RL
Sbjct: 632 ALSGGNWDSISDAAKDVVSKMLHVDPHQRL 661
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 196 bits (498), Expect = 6e-50
Identities = 119/314 (37%), Positives = 171/314 (54%), Gaps = 14/314 (4%)
Query: 183 NIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242
N H ++F ++IG+G FG+V R YA+K L KK I K+ E ++ER +
Sbjct: 90 NPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNV 149
Query: 243 LSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEII 302
L + PF+V + ++F T DKL F+LD +NGG+L YHL + F E RFYA EI
Sbjct: 150 L--LKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIA 207
Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASV--GTHGYMAPE 360
L ++H+ +VYRDLKP NILLD GH ++D GL + + S GT Y+APE
Sbjct: 208 SALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPE 267
Query: 361 VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE 420
VL K YD + DW+ LG +L+++L G PF T + ++ L ++L +
Sbjct: 268 VLHK-QPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYD---NILNKPLQLKPNITNS 323
Query: 421 LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA 480
+ LLEGLLQ+D +KRLG E+K H FF ++W + +K PP P N +
Sbjct: 324 ARHLLEGLLQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNP-----NVS 377
Query: 481 DAFDIGSFDEEDTK 494
D+ FD E T+
Sbjct: 378 GPNDLRHFDPEFTE 391
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 196 bits (498), Expect = 6e-50
Identities = 119/314 (37%), Positives = 171/314 (54%), Gaps = 14/314 (4%)
Query: 183 NIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242
N H ++F ++IG+G FG+V R YA+K L KK I K+ E ++ER +
Sbjct: 104 NPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNV 163
Query: 243 LSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEII 302
L + PF+V + ++F T DKL F+LD +NGG+L YHL + F E RFYA EI
Sbjct: 164 L--LKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIA 221
Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASV--GTHGYMAPE 360
L ++H+ +VYRDLKP NILLD GH ++D GL + + S GT Y+APE
Sbjct: 222 SALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPE 281
Query: 361 VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE 420
VL K YD + DW+ LG +L+++L G PF T + ++ L ++L +
Sbjct: 282 VLHK-QPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYD---NILNKPLQLKPNITNS 337
Query: 421 LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA 480
+ LLEGLLQ+D +KRLG E+K H FF ++W + +K PP P N +
Sbjct: 338 ARHLLEGLLQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNP-----NVS 391
Query: 481 DAFDIGSFDEEDTK 494
D+ FD E T+
Sbjct: 392 GPNDLRHFDPEFTE 405
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 196 bits (498), Expect = 6e-50
Identities = 119/314 (37%), Positives = 171/314 (54%), Gaps = 14/314 (4%)
Query: 183 NIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242
N H ++F ++IG+G FG+V R YA+K L KK I K+ E ++ER +
Sbjct: 118 NPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNV 177
Query: 243 LSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEII 302
L + PF+V + ++F T DKL F+LD +NGG+L YHL + F E RFYA EI
Sbjct: 178 L--LKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIA 235
Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASV--GTHGYMAPE 360
L ++H+ +VYRDLKP NILLD GH ++D GL + + S GT Y+APE
Sbjct: 236 SALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPE 295
Query: 361 VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE 420
VL K YD + DW+ LG +L+++L G PF T + ++ L ++L +
Sbjct: 296 VLHK-QPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYD---NILNKPLQLKPNITNS 351
Query: 421 LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA 480
+ LLEGLLQ+D +KRLG E+K H FF ++W + +K PP P N +
Sbjct: 352 ARHLLEGLLQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNP-----NVS 405
Query: 481 DAFDIGSFDEEDTK 494
D+ FD E T+
Sbjct: 406 GPNDLRHFDPEFTE 419
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,927,994
Number of Sequences: 37866
Number of extensions: 1220141
Number of successful extensions: 5398
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 669
Number of HSP's successfully gapped in prelim test: 134
Number of HSP's that attempted gapping in prelim test: 3259
Number of HSP's gapped (non-prelim): 990
length of query: 688
length of database: 18,247,518
effective HSP length: 109
effective length of query: 579
effective length of database: 14,120,124
effective search space: 8175551796
effective search space used: 8175551796
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.