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Search of human proteins with 148539876
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens]
(689 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens] 1400 0.0
gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens] 1215 0.0
gi|51896037 G protein-coupled receptor kinase 6 isoform C [Homo ... 313 4e-85
gi|51896039 G protein-coupled receptor kinase 6 isoform A [Homo ... 313 4e-85
gi|51896035 G protein-coupled receptor kinase 6 isoform B [Homo ... 313 4e-85
gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens] 310 4e-84
gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [H... 300 2e-81
gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [H... 298 1e-80
gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Ho... 297 2e-80
gi|4506529 rhodopsin kinase [Homo sapiens] 274 2e-73
gi|21166359 G-protein-coupled receptor kinase 7 [Homo sapiens] 259 8e-69
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 218 1e-56
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 218 1e-56
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 213 6e-55
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 212 8e-55
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 212 8e-55
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 211 2e-54
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 211 2e-54
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 209 5e-54
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 208 2e-53
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 208 2e-53
gi|4502023 AKT2 kinase [Homo sapiens] 204 2e-52
gi|62241015 AKT1 kinase [Homo sapiens] 199 9e-51
gi|62241013 AKT1 kinase [Homo sapiens] 199 9e-51
gi|62241011 AKT1 kinase [Homo sapiens] 199 9e-51
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 198 1e-50
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 198 1e-50
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 196 5e-50
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 196 5e-50
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 196 5e-50
>gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens]
Length = 689
Score = 1400 bits (3624), Expect = 0.0
Identities = 689/689 (100%), Positives = 689/689 (100%)
Query: 1 MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS 60
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS
Sbjct: 1 MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS 60
Query: 61 QKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLAC 120
QKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLAC
Sbjct: 61 QKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLAC 120
Query: 121 SHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV 180
SHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV
Sbjct: 121 SHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV 180
Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240
ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
Sbjct: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240
Query: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE 300
IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE
Sbjct: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE 300
Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE 360
IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE
Sbjct: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE 360
Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420
VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE
Sbjct: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420
Query: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA 480
LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA
Sbjct: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA 480
Query: 481 DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK 540
DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK
Sbjct: 481 DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK 540
Query: 541 KAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL 600
KAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL
Sbjct: 541 KAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL 600
Query: 601 LTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQR 660
LTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQR
Sbjct: 601 LTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQR 660
Query: 661 VPKMKNKPRSPVVELSKVPLVQRGSANGL 689
VPKMKNKPRSPVVELSKVPLVQRGSANGL
Sbjct: 661 VPKMKNKPRSPVVELSKVPLVQRGSANGL 689
>gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens]
Length = 688
Score = 1215 bits (3143), Expect = 0.0
Identities = 579/689 (84%), Positives = 639/689 (92%), Gaps = 1/689 (0%)
Query: 1 MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS 60
MADLEAVLADVSYLMAMEKSKATPAARASK+I+LPEPSIRSVMQKYL +R E+TF+KIF+
Sbjct: 1 MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN 60
Query: 61 QKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLAC 120
QK+G+LLF+DFCLN + EA P V+FYEEIK+YEKL+ EE+R+ RSR+I+D+YIMKELL+C
Sbjct: 61 QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC 120
Query: 121 SHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV 180
SHPFSK A EHVQ HL KKQV LFQPYIEEIC++LRGD+FQKF+ESDKFTRFCQWKNV
Sbjct: 121 SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV 180
Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240
ELNIHLTMN+FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
Sbjct: 181 ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240
Query: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE 300
IMLSLVSTGDCPFIVCM+YAFHTPDKL FILDLMNGGDLHYHLSQHGVFSE +MRFYA E
Sbjct: 241 IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE 300
Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE 360
IILGLEHMHNRFVVYRDLKPANILLDEHGH RISDLGLACDFSKKKPHASVGTHGYMAPE
Sbjct: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPE 360
Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420
VLQKG AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLT+ VELPD+FSPE
Sbjct: 361 VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE 420
Query: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA 480
L+SLLEGLLQRDV++RLGC G G+QEVKE FF+ +DWQ V+LQKYPPPLIPPRGEVNAA
Sbjct: 421 LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA 480
Query: 481 DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK 540
DAFDIGSFDEEDTKGIKLLD DQELY+NFPL ISERWQQEV ETV++ +NA+TD++EARK
Sbjct: 481 DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARK 540
Query: 541 KAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL 600
+AKNKQLGHEEDYALGKDCIMHGYM K+GNPFLTQWQRRYFYLFPNRLEWRGEGE+ Q+L
Sbjct: 541 RAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNL 600
Query: 601 LTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQR 660
LTME+I SVEETQIK++KC+L +I+GGKQF+LQC+SDPE VQWKKEL + ++EAQ+L++R
Sbjct: 601 LTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRR 660
Query: 661 VPKMKNKPRSPVVELSKVPLVQRGSANGL 689
PK NKPRS VEL K L R S NGL
Sbjct: 661 APKFLNKPRSGTVELPKPSLCHRNS-NGL 688
>gi|51896037 G protein-coupled receptor kinase 6 isoform C [Homo
sapiens]
Length = 560
Score = 313 bits (801), Expect = 4e-85
Identities = 203/531 (38%), Positives = 294/531 (55%), Gaps = 23/531 (4%)
Query: 3 DLEAVLADVSYLMAMEKSKATPAARASK---KILLPEPSIRSVMQKYLEDRGEVTFEKIF 59
+LE ++A+ L A E ++ K + P S ++ LE E+
Sbjct: 2 ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCER-- 59
Query: 60 SQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLA 119
Q +G LLFR+FC E +R V F + + +YE + +++R A R++ +++
Sbjct: 60 -QPIGRLLFREFCATRPELSR-CVAFLDGVAEYE-VTPDDKRKACGRQLTQNFLSHTGPD 116
Query: 120 CSHPFSKSATEHVQGHLGKKQVP-PDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWK 178
+ + L +Q P DLFQ + L F +++S F RF QWK
Sbjct: 117 LIPEVPRQLVTNCTQRL--EQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWK 174
Query: 179 NVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALN 238
+E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++GE +ALN
Sbjct: 175 WLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN 233
Query: 239 ERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRF 296
E+ +L V++ F+V ++YA+ T D L +L LMNGGDL +H+ G F EA F
Sbjct: 234 EKQILEKVNSR---FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVF 290
Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP-HASVGTHG 355
YAAEI GLE +H +VYRDLKP NILLD+HGH+RISDLGLA + + VGT G
Sbjct: 291 YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVG 350
Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELP 414
YMAPEV+ K Y S DW++LGC+L++++ G SPF+Q K K K E++R+ + E
Sbjct: 351 YMAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYS 409
Query: 415 DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPR 474
+ FSP+ RSL LL +D RLGC G A+EVKE P F+ L+++ + PP P
Sbjct: 410 ERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDP 469
Query: 475 GEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET 524
+ D DI F KG++L +DQ+ Y+ F ++ WQ E+ ET
Sbjct: 470 QAIYCKDVLDIEQF--STVKGVELEPTDQDFYQKFATGSVPIPWQNEMVET 518
>gi|51896039 G protein-coupled receptor kinase 6 isoform A [Homo
sapiens]
Length = 576
Score = 313 bits (801), Expect = 4e-85
Identities = 203/531 (38%), Positives = 294/531 (55%), Gaps = 23/531 (4%)
Query: 3 DLEAVLADVSYLMAMEKSKATPAARASK---KILLPEPSIRSVMQKYLEDRGEVTFEKIF 59
+LE ++A+ L A E ++ K + P S ++ LE E+
Sbjct: 2 ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCER-- 59
Query: 60 SQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLA 119
Q +G LLFR+FC E +R V F + + +YE + +++R A R++ +++
Sbjct: 60 -QPIGRLLFREFCATRPELSR-CVAFLDGVAEYE-VTPDDKRKACGRQLTQNFLSHTGPD 116
Query: 120 CSHPFSKSATEHVQGHLGKKQVP-PDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWK 178
+ + L +Q P DLFQ + L F +++S F RF QWK
Sbjct: 117 LIPEVPRQLVTNCTQRL--EQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWK 174
Query: 179 NVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALN 238
+E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++GE +ALN
Sbjct: 175 WLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN 233
Query: 239 ERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRF 296
E+ +L V++ F+V ++YA+ T D L +L LMNGGDL +H+ G F EA F
Sbjct: 234 EKQILEKVNSR---FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVF 290
Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP-HASVGTHG 355
YAAEI GLE +H +VYRDLKP NILLD+HGH+RISDLGLA + + VGT G
Sbjct: 291 YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVG 350
Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELP 414
YMAPEV+ K Y S DW++LGC+L++++ G SPF+Q K K K E++R+ + E
Sbjct: 351 YMAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYS 409
Query: 415 DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPR 474
+ FSP+ RSL LL +D RLGC G A+EVKE P F+ L+++ + PP P
Sbjct: 410 ERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDP 469
Query: 475 GEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET 524
+ D DI F KG++L +DQ+ Y+ F ++ WQ E+ ET
Sbjct: 470 QAIYCKDVLDIEQF--STVKGVELEPTDQDFYQKFATGSVPIPWQNEMVET 518
>gi|51896035 G protein-coupled receptor kinase 6 isoform B [Homo
sapiens]
Length = 589
Score = 313 bits (801), Expect = 4e-85
Identities = 203/531 (38%), Positives = 294/531 (55%), Gaps = 23/531 (4%)
Query: 3 DLEAVLADVSYLMAMEKSKATPAARASK---KILLPEPSIRSVMQKYLEDRGEVTFEKIF 59
+LE ++A+ L A E ++ K + P S ++ LE E+
Sbjct: 2 ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCER-- 59
Query: 60 SQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLA 119
Q +G LLFR+FC E +R V F + + +YE + +++R A R++ +++
Sbjct: 60 -QPIGRLLFREFCATRPELSR-CVAFLDGVAEYE-VTPDDKRKACGRQLTQNFLSHTGPD 116
Query: 120 CSHPFSKSATEHVQGHLGKKQVP-PDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWK 178
+ + L +Q P DLFQ + L F +++S F RF QWK
Sbjct: 117 LIPEVPRQLVTNCTQRL--EQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWK 174
Query: 179 NVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALN 238
+E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++GE +ALN
Sbjct: 175 WLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN 233
Query: 239 ERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRF 296
E+ +L V++ F+V ++YA+ T D L +L LMNGGDL +H+ G F EA F
Sbjct: 234 EKQILEKVNSR---FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVF 290
Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP-HASVGTHG 355
YAAEI GLE +H +VYRDLKP NILLD+HGH+RISDLGLA + + VGT G
Sbjct: 291 YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVG 350
Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELP 414
YMAPEV+ K Y S DW++LGC+L++++ G SPF+Q K K K E++R+ + E
Sbjct: 351 YMAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYS 409
Query: 415 DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPR 474
+ FSP+ RSL LL +D RLGC G A+EVKE P F+ L+++ + PP P
Sbjct: 410 ERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDP 469
Query: 475 GEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET 524
+ D DI F KG++L +DQ+ Y+ F ++ WQ E+ ET
Sbjct: 470 QAIYCKDVLDIEQF--STVKGVELEPTDQDFYQKFATGSVPIPWQNEMVET 518
>gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens]
Length = 590
Score = 310 bits (793), Expect = 4e-84
Identities = 186/473 (39%), Positives = 268/473 (56%), Gaps = 23/473 (4%)
Query: 61 QKLGYLLFRDFCLNHLEEARP----LVEFYEEIKKYEKLETEEERVARSREIFDSYIMKE 116
Q +G LLFR FC E RP ++F + + +YE + +E+ + +EI Y+ +
Sbjct: 60 QPIGRLLFRQFC-----ETRPGLECYIQFLDSVAEYE-VTPDEKLGEKGKEIMTKYLTPK 113
Query: 117 LLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQ 176
+ + L +K +LF + + + LRG+ F ++++S F RF Q
Sbjct: 114 SPVFIAQVGQDLVSQTEEKLLQKPCK-ELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQ 172
Query: 177 WKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLA 236
WK +E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++GE++A
Sbjct: 173 WKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA 231
Query: 237 LNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADM 294
LNE+ +L V++ F+V ++YA+ T D L +L +MNGGDL +H+ G F E
Sbjct: 232 LNEKQILEKVNS---QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERA 288
Query: 295 RFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHASVGT 353
FYAAEI+ GLE +H VYRDLKP NILLD++GH+RISDLGLA + VGT
Sbjct: 289 LFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT 348
Query: 354 HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVE 412
GYMAPEVL Y S D++ LGC++++++ G SPFR K K K E+DR L
Sbjct: 349 VGYMAPEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV 407
Query: 413 LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP 472
FS E +S+ + LL +D +RLGC GA EVK PFFR+++++ + PP +P
Sbjct: 408 YSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467
Query: 473 PRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET 524
V D DI F KG+ L +D + Y F ++S WQ E+ ET
Sbjct: 468 DPRAVYCKDVLDIEQF--STVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIET 518
>gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [Homo
sapiens]
Length = 578
Score = 300 bits (769), Expect = 2e-81
Identities = 198/544 (36%), Positives = 298/544 (54%), Gaps = 35/544 (6%)
Query: 3 DLEAVLADVSYLMAMEKSKATPAARASKK---ILLPEPSIRSVMQKYLEDRGEVTFEKIF 59
+LE ++A+ L A + + R+ K + LP S S ++ +E +K
Sbjct: 2 ELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDK-- 59
Query: 60 SQKLGYLLFRDFCLNHLEEARPL----VEFYEEIKKYEKLETEEERVARSREIFDSYIMK 115
Q +G LFR FC + +P +EF + + +YE + +E+R I D +
Sbjct: 60 -QPIGRRLFRQFC-----DTKPTLKRHIEFLDAVAEYEVAD-DEDRSDCGLSILDRFFND 112
Query: 116 ELLACSHPFSKSATEHV-QGHLGKKQVPPD--LFQPYIEEICQNLRGDVFQKFIESDKFT 172
+L A P + + V + LG K+ P F+ LRG+ F+++ ES F+
Sbjct: 113 KLAA---PLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFS 169
Query: 173 RFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQG 232
+F QWK +E +T N F +R++G+GGFGEV C+ TGKMYA K L KKRIK ++G
Sbjct: 170 QFLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKG 228
Query: 233 ETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFS 290
E +ALNE+ +L V + F+V ++YA+ T D L +L +MNGGDL +H+ G F
Sbjct: 229 EAMALNEKRILEKVQS---RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFD 285
Query: 291 EADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHA 349
E FYAAE+ GLE + +VYRDLKP NILLD+ GH+RISDLGLA + + ++
Sbjct: 286 EQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRG 345
Query: 350 SVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLT 408
VGT GYMAPEV+ Y S DW+ LGC+++++++GHSPF+++K K K E+D+
Sbjct: 346 RVGTVGYMAPEVV-NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKN 404
Query: 409 MAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPP 468
E + FS + +S+ LL ++ ++RLGC G GA VK+ P F+ ++++ + P
Sbjct: 405 DTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEP 464
Query: 469 PLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VF 526
P P V D DI F KGI L +D++ Y F +S WQ E+ E+ F
Sbjct: 465 PFCPDPHAVYCKDVLDIEQFSV--VKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCF 522
Query: 527 DTIN 530
IN
Sbjct: 523 KDIN 526
>gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [Homo
sapiens]
Length = 532
Score = 298 bits (762), Expect = 1e-80
Identities = 194/533 (36%), Positives = 292/533 (54%), Gaps = 34/533 (6%)
Query: 3 DLEAVLADVSYLMAMEKSKATPAARASKK---ILLPEPSIRSVMQKYLEDRGEVTFEKIF 59
+LE ++A+ L A + + R+ K + LP S S ++ +E +K
Sbjct: 2 ELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDK-- 59
Query: 60 SQKLGYLLFRDFCLNHLEEARPL----VEFYEEIKKYEKLETEEERVARSREIFDSYIMK 115
Q +G LFR FC + +P +EF + + +YE + +E+R I D +
Sbjct: 60 -QPIGRRLFRQFC-----DTKPTLKRHIEFLDAVAEYEVAD-DEDRSDCGLSILDRFFND 112
Query: 116 ELLACSHPFSKSATEHV-QGHLGKKQVPPD--LFQPYIEEICQNLRGDVFQKFIESDKFT 172
+L A P + + V + LG K+ P F+ LRG+ F+++ ES F+
Sbjct: 113 KLAA---PLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFS 169
Query: 173 RFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQG 232
+F QWK +E +T N F +R++G+GGFGEV C+ TGKMYA K L KKRIK ++G
Sbjct: 170 QFLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKG 228
Query: 233 ETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFS 290
E +ALNE+ +L V + F+V ++YA+ T D L +L +MNGGDL +H+ G F
Sbjct: 229 EAMALNEKRILEKVQS---RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFD 285
Query: 291 EADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHA 349
E FYAAE+ GLE + +VYRDLKP NILLD+ GH+RISDLGLA + + ++
Sbjct: 286 EQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRG 345
Query: 350 SVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLT 408
VGT GYMAPEV+ Y S DW+ LGC+++++++GHSPF+++K K K E+D+
Sbjct: 346 RVGTVGYMAPEVV-NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKN 404
Query: 409 MAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPP 468
E + FS + +S+ LL ++ ++RLGC G GA VK+ P F+ ++++ + P
Sbjct: 405 DTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEP 464
Query: 469 PLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQE 520
P P V D DI F KGI L +D++ Y F +S WQ E
Sbjct: 465 PFCPDPHAVYCKDVLDIEQFSV--VKGIYLDTADEDFYARFATGCVSIPWQNE 515
>gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Homo
sapiens]
Length = 546
Score = 297 bits (761), Expect = 2e-80
Identities = 185/483 (38%), Positives = 273/483 (56%), Gaps = 29/483 (6%)
Query: 61 QKLGYLLFRDFCLNHLEEARPL----VEFYEEIKKYEKLETEEERVARSREIFDSYIMKE 116
Q +G LFR FC + +P +EF + + +YE + +E+R I D + +
Sbjct: 28 QPIGRRLFRQFC-----DTKPTLKRHIEFLDAVAEYEVAD-DEDRSDCGLSILDRFFNDK 81
Query: 117 LLACSHPFSKSATEHV-QGHLGKKQVPPD--LFQPYIEEICQNLRGDVFQKFIESDKFTR 173
L A P + + V + LG K+ P F+ LRG+ F+++ ES F++
Sbjct: 82 LAA---PLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQ 138
Query: 174 FCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE 233
F QWK +E +T N F +R++G+GGFGEV C+ TGKMYA K L KKRIK ++GE
Sbjct: 139 FLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGE 197
Query: 234 TLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSE 291
+ALNE+ +L V + F+V ++YA+ T D L +L +MNGGDL +H+ G F E
Sbjct: 198 AMALNEKRILEKVQS---RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDE 254
Query: 292 ADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHAS 350
FYAAE+ GLE + +VYRDLKP NILLD+ GH+RISDLGLA + + ++
Sbjct: 255 QRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGR 314
Query: 351 VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTM 409
VGT GYMAPEV+ Y S DW+ LGC+++++++GHSPF+++K K K E+D+
Sbjct: 315 VGTVGYMAPEVV-NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKND 373
Query: 410 AVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPP 469
E + FS + +S+ LL ++ ++RLGC G GA VK+ P F+ ++++ + PP
Sbjct: 374 TEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPP 433
Query: 470 LIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VFD 527
P V D DI F KGI L +D++ Y F +S WQ E+ E+ F
Sbjct: 434 FCPDPHAVYCKDVLDIEQFSV--VKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFK 491
Query: 528 TIN 530
IN
Sbjct: 492 DIN 494
>gi|4506529 rhodopsin kinase [Homo sapiens]
Length = 563
Score = 274 bits (700), Expect = 2e-73
Identities = 180/539 (33%), Positives = 289/539 (53%), Gaps = 24/539 (4%)
Query: 4 LEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQ-KYLEDRGEVTFEKI-FSQ 61
LE V+A+ +++ A + + + K L + + + + + L D + FE + Q
Sbjct: 6 LETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFESVCLEQ 65
Query: 62 KLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKEL-LAC 120
+G LF+ F L E+ P +E +++I+ Y+ + + + +++ I Y+ + L C
Sbjct: 66 PIGKKLFQQF-LQSAEKHLPALELWKDIEDYDTADNDLQP-QKAQTILAQYLDPQAKLFC 123
Query: 121 SHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV 180
S + +G + ++ LFQP ++ +L FQ+++ S F RF QWK +
Sbjct: 124 SFLDEGIVAKFKEGPV---EIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWL 180
Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240
E + + F R++G+GGFGEV C+ TGK+YA K L+KKR+K ++G A+ E+
Sbjct: 181 EAQ-PMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEK 239
Query: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL----SQHGVFSEADMRF 296
+L V + FIV ++YAF T L ++ +MNGGD+ YH+ ++ F E F
Sbjct: 240 KILMKVHSR---FIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALF 296
Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTH 354
Y A+II GLEH+H R +VYRDLKP N+LLD G+VRISDLGLA + + K GT
Sbjct: 297 YTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTP 356
Query: 355 GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK-DKHEIDRMTLTMAVEL 413
G+MAPE+LQ G YD S D+F+LG L++++ PFR K + E+ ++ V+
Sbjct: 357 GFMAPELLQ-GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKY 415
Query: 414 PDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPP 473
PD FS + E LL++D +RLG +++ P F+ L+W+ + PP IP
Sbjct: 416 PDKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPD 475
Query: 474 RGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VFDTIN 530
V A D D+G+F KG+ +D E ++ F WQ+E+ ET +F +N
Sbjct: 476 SKTVYAKDIQDVGAF--STVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELN 532
>gi|21166359 G-protein-coupled receptor kinase 7 [Homo sapiens]
Length = 553
Score = 259 bits (661), Expect = 8e-69
Identities = 168/539 (31%), Positives = 290/539 (53%), Gaps = 20/539 (3%)
Query: 1 MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS 60
M L+ ++A+ +YL A + S ++ L P ++ + L + + F +
Sbjct: 4 MGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAE--LRQKLSLNFHSLCE 61
Query: 61 QK-LGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLA 119
Q+ +G LFRDF L + R F E+++ +E E + + + + +
Sbjct: 62 QQPIGRRLFRDF-LATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPG 120
Query: 120 CSHPF-SKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWK 178
PF S++ Q +++ + E + L+ F+ F+ S + +F QWK
Sbjct: 121 NPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAF-LQEQPFKDFVTSAFYDKFLQWK 179
Query: 179 NVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALN 238
E+ ++ F+ R++G+GGFGEV + +TGKMYA K LDKKR+K K GE +AL
Sbjct: 180 LFEMQ-PVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALL 238
Query: 239 ERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRF 296
E+ +L VS+ PFIV ++YAF + L ++ LMNGGDL +H+ G + + F
Sbjct: 239 EKEILEKVSS---PFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIF 295
Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTHG 355
Y+A+I G+ H+H +VYRD+KP N+LLD+ G+ R+SDLGLA + KP GT+G
Sbjct: 296 YSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNG 355
Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK-DKHEIDRMTLTMAVELP 414
YMAPE+L + V+Y DWF++GC +++++ G +PF+ +K K K ++ + TL V+
Sbjct: 356 YMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQ 415
Query: 415 -DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPP 473
D+F+ E + + L + +RLG + + + ++ FF+++++ + PP +P
Sbjct: 416 HDNFTEEAKDICRLFLAKKPEQRLGSREK-SDDPRKHHFFKTINFPRLEAGLIEPPFVPD 474
Query: 474 RGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VFDTIN 530
V A D +I F E +G++ D D++ ++NF + WQ+E+ ET +F+ +N
Sbjct: 475 PSVVYAKDIAEIDDFSE--VRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELN 531
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 218 bits (555), Expect = 1e-56
Identities = 121/317 (38%), Positives = 184/317 (58%), Gaps = 15/317 (4%)
Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMK-QGETLALNERI 241
+++ +F + +++G G +G+V+ RKA D GK+YAMK L K + + + + ER
Sbjct: 28 VSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERS 87
Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301
+L LV PF+V + YAF T KL ILD ++GG++ HL Q F EA++R Y EI
Sbjct: 88 VLELVR--QAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEI 145
Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF---SKKKPHASVGTHGYMA 358
+L LEH+H ++YRDLK N+LLD GH+ ++D GL+ +F K++ + GT YMA
Sbjct: 146 VLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMA 205
Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR-QHKTKDKHEIDRMTLTMAVELPDSF 417
PE+++ + + DW+SLG +LF+LL G SPF + + + E+ R L + P
Sbjct: 206 PEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRI 265
Query: 418 SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEV 477
P + LL+ LL +D +RLG +GAQEV+ PFF+ LDW + +K P P P
Sbjct: 266 GPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRP----- 320
Query: 478 NAADAFDIGSFDEEDTK 494
D+G+F EE T+
Sbjct: 321 QIRSELDVGNFAEEFTR 337
Score = 82.4 bits (202), Expect = 1e-15
Identities = 83/287 (28%), Positives = 130/287 (45%), Gaps = 40/287 (13%)
Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256
+G+G F CR+ +G+ +A+K L ++ Q E AL R+ S P +V
Sbjct: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAAL--RLCQSH------PNVVN 462
Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF-VVY 315
+ H +L+L+ GG+L H+ + FSE++ ++ + MH VV+
Sbjct: 463 LHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVH 522
Query: 316 RDLKPANILLDEH---GHVRISDLGLACDFSKKKPHAS-------VGTHGYMAPEVL-QK 364
RDLKP NIL + V+I D G F++ +P + T Y APE+L Q+
Sbjct: 523 RDLKPENILYADDTPGAPVKIIDFG----FARLRPQSPGVPMQTPCFTLQYAAPELLAQQ 578
Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPF--------RQHKTKDKHEIDRMTLTMAVELPDS 416
G YD S D +SLG +L+ +L G PF + + +I ++ E
Sbjct: 579 G--YDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQG 636
Query: 417 FSPELRSLLEGLLQRDVNRRLGCLG-RGAQ-----EVKESPFFRSLD 457
S E + L+ GLL D +RL G RG+ + SP R+ D
Sbjct: 637 VSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPD 683
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 218 bits (555), Expect = 1e-56
Identities = 121/317 (38%), Positives = 184/317 (58%), Gaps = 15/317 (4%)
Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMK-QGETLALNERI 241
+++ +F + +++G G +G+V+ RKA D GK+YAMK L K + + + + ER
Sbjct: 28 VSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERS 87
Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301
+L LV PF+V + YAF T KL ILD ++GG++ HL Q F EA++R Y EI
Sbjct: 88 VLELVR--QAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEI 145
Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF---SKKKPHASVGTHGYMA 358
+L LEH+H ++YRDLK N+LLD GH+ ++D GL+ +F K++ + GT YMA
Sbjct: 146 VLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMA 205
Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR-QHKTKDKHEIDRMTLTMAVELPDSF 417
PE+++ + + DW+SLG +LF+LL G SPF + + + E+ R L + P
Sbjct: 206 PEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRI 265
Query: 418 SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEV 477
P + LL+ LL +D +RLG +GAQEV+ PFF+ LDW + +K P P P
Sbjct: 266 GPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRP----- 320
Query: 478 NAADAFDIGSFDEEDTK 494
D+G+F EE T+
Sbjct: 321 QIRSELDVGNFAEEFTR 337
Score = 82.4 bits (202), Expect = 1e-15
Identities = 83/287 (28%), Positives = 130/287 (45%), Gaps = 40/287 (13%)
Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256
+G+G F CR+ +G+ +A+K L ++ Q E AL R+ S P +V
Sbjct: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAAL--RLCQSH------PNVVN 468
Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF-VVY 315
+ H +L+L+ GG+L H+ + FSE++ ++ + MH VV+
Sbjct: 469 LHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVH 528
Query: 316 RDLKPANILLDEH---GHVRISDLGLACDFSKKKPHAS-------VGTHGYMAPEVL-QK 364
RDLKP NIL + V+I D G F++ +P + T Y APE+L Q+
Sbjct: 529 RDLKPENILYADDTPGAPVKIIDFG----FARLRPQSPGVPMQTPCFTLQYAAPELLAQQ 584
Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPF--------RQHKTKDKHEIDRMTLTMAVELPDS 416
G YD S D +SLG +L+ +L G PF + + +I ++ E
Sbjct: 585 G--YDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQG 642
Query: 417 FSPELRSLLEGLLQRDVNRRLGCLG-RGAQ-----EVKESPFFRSLD 457
S E + L+ GLL D +RL G RG+ + SP R+ D
Sbjct: 643 VSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPD 689
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 213 bits (541), Expect = 6e-55
Identities = 123/345 (35%), Positives = 199/345 (57%), Gaps = 16/345 (4%)
Query: 189 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245
+ F + +++G+G FG+V+ +K +D ++YAMK L K +K++ + I++ +
Sbjct: 66 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEV 125
Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305
+ PFIV + YAF T KL ILD + GGDL LS+ +F+E D++FY AE+ L L
Sbjct: 126 ----NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAL 181
Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQ 363
+H+H+ ++YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+
Sbjct: 182 DHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVN 241
Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423
+ + SADW+S G ++F++L G PF + KD+ E M L + +P SPE +S
Sbjct: 242 RR-GHTQSADWWSFGVLMFEMLTGTLPF---QGKDRKETMTMILKAKLGMPQFLSPEAQS 297
Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAF 483
LL L +R+ RLG G +E+K FF ++DW ++ ++ PP P G F
Sbjct: 298 LLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYF 357
Query: 484 D--IGSFDEEDTKGIKLLDSDQELYRNFP-LTISERWQQEVAETV 525
D + +D+ GI + +L+R F + I+ + + +TV
Sbjct: 358 DPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTV 402
Score = 82.8 bits (203), Expect = 1e-15
Identities = 77/262 (29%), Positives = 124/262 (47%), Gaps = 30/262 (11%)
Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250
+ V IG G + C T +A+K +DK K+ T E I + L+ G
Sbjct: 422 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKS----KRDPT----EEIEI-LLRYGQ 472
Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310
P I+ + + + + +LM GG+L + + FSE + I +E++H
Sbjct: 473 HPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHA 532
Query: 311 RFVVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKKPHASVG-------THGYMAP 359
+ VV+RDLKP+NIL +DE G+ +RI D G A K+ A G T ++AP
Sbjct: 533 QGVVHRDLKPSNILYVDESGNPESIRICDFGFA-----KQLRAENGLLMTPCYTANFVAP 587
Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE----IDRMTLTMAVELPD 415
EVL K YD++ D +SLG +L+ +L G++PF E I +++ +
Sbjct: 588 EVL-KRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWN 646
Query: 416 SFSPELRSLLEGLLQRDVNRRL 437
S S + L+ +L D ++RL
Sbjct: 647 SVSDTAKDLVSKMLHVDPHQRL 668
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 212 bits (540), Expect = 8e-55
Identities = 120/326 (36%), Positives = 190/326 (58%), Gaps = 15/326 (4%)
Query: 191 FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247
F + +++G+G FG+V+ RK D+G +YAMK L K +K++ + I+ +
Sbjct: 71 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADV-- 128
Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307
+ PF+V + YAF T KL ILD + GGDL LS+ +F+E D++FY AE+ LGL+H
Sbjct: 129 --NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDH 186
Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQKG 365
+H+ ++YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+ +
Sbjct: 187 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNR- 245
Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425
+ SADW+S G ++F++L G PF + KD+ E + L + +P S E +SLL
Sbjct: 246 QGHSHSADWWSYGVLMFEMLTGSLPF---QGKDRKETMTLILKAKLGMPQFLSTEAQSLL 302
Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFD- 484
L +R+ RLG GA+E+K F+ ++DW ++ ++ PP P + + FD
Sbjct: 303 RALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDT 362
Query: 485 -IGSFDEEDTKGIKLLDSDQELYRNF 509
S +D+ GI +L+R F
Sbjct: 363 EFTSRTPKDSPGIPPSAGAHQLFRGF 388
Score = 91.3 bits (225), Expect = 3e-18
Identities = 82/282 (29%), Positives = 132/282 (46%), Gaps = 35/282 (12%)
Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250
+ V IG G + E C T YA+K +DK K E + + L+ G
Sbjct: 427 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS--KRDPSEEIEI-------LLRYGQ 477
Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310
P I+ + + + + +LM GG+L + + FSE + F I +E++H+
Sbjct: 478 HPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHS 537
Query: 311 RFVVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKKPHASVG-------THGYMAP 359
+ VV+RDLKP+NIL +DE G+ +RI D G A K+ A G T ++AP
Sbjct: 538 QGVVHRDLKPSNILYVDESGNPECLRICDFGFA-----KQLRAENGLLMTPCYTANFVAP 592
Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE----IDRMTLTMAVELPD 415
EVL K YD D +SLG +L+ +L G++PF + E I T++ +
Sbjct: 593 EVL-KRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 651
Query: 416 SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457
+ S + L+ +L D ++RL A++V + P+ D
Sbjct: 652 TVSETAKDLVSKMLHVDPHQRL-----TAKQVLQHPWVTQKD 688
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 212 bits (540), Expect = 8e-55
Identities = 120/326 (36%), Positives = 190/326 (58%), Gaps = 15/326 (4%)
Query: 191 FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247
F + +++G+G FG+V+ RK D+G +YAMK L K +K++ + I+ +
Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADV-- 119
Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307
+ PF+V + YAF T KL ILD + GGDL LS+ +F+E D++FY AE+ LGL+H
Sbjct: 120 --NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDH 177
Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQKG 365
+H+ ++YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+ +
Sbjct: 178 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNR- 236
Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425
+ SADW+S G ++F++L G PF + KD+ E + L + +P S E +SLL
Sbjct: 237 QGHSHSADWWSYGVLMFEMLTGSLPF---QGKDRKETMTLILKAKLGMPQFLSTEAQSLL 293
Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFD- 484
L +R+ RLG GA+E+K F+ ++DW ++ ++ PP P + + FD
Sbjct: 294 RALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDT 353
Query: 485 -IGSFDEEDTKGIKLLDSDQELYRNF 509
S +D+ GI +L+R F
Sbjct: 354 EFTSRTPKDSPGIPPSAGAHQLFRGF 379
Score = 91.3 bits (225), Expect = 3e-18
Identities = 82/282 (29%), Positives = 132/282 (46%), Gaps = 35/282 (12%)
Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250
+ V IG G + E C T YA+K +DK K E + + L+ G
Sbjct: 418 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS--KRDPSEEIEI-------LLRYGQ 468
Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310
P I+ + + + + +LM GG+L + + FSE + F I +E++H+
Sbjct: 469 HPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHS 528
Query: 311 RFVVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKKPHASVG-------THGYMAP 359
+ VV+RDLKP+NIL +DE G+ +RI D G A K+ A G T ++AP
Sbjct: 529 QGVVHRDLKPSNILYVDESGNPECLRICDFGFA-----KQLRAENGLLMTPCYTANFVAP 583
Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE----IDRMTLTMAVELPD 415
EVL K YD D +SLG +L+ +L G++PF + E I T++ +
Sbjct: 584 EVL-KRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 642
Query: 416 SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457
+ S + L+ +L D ++RL A++V + P+ D
Sbjct: 643 TVSETAKDLVSKMLHVDPHQRL-----TAKQVLQHPWVTQKD 679
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 211 bits (536), Expect = 2e-54
Identities = 120/338 (35%), Positives = 193/338 (57%), Gaps = 15/338 (4%)
Query: 189 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245
+ F + +++G+G +G+V+ RK +D G++YAMK L K +K++ + ++ +
Sbjct: 65 SQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRD----RVRSKMERDI 120
Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305
++ + PFIV + YAF T KL ILD + GGDL LS+ +F+E D++FY AE+ L L
Sbjct: 121 LAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAL 180
Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQ 363
+H+H+ ++YRDLKP NILLDE GH++I+D GL+ + K+ ++ GT YMAPEV+
Sbjct: 181 DHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVN 240
Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423
+ + SADW+S G ++F++L G PF + KD+ E + L + +P S E +S
Sbjct: 241 RR-GHTQSADWWSFGVLMFEMLTGSLPF---QGKDRKETMALILKAKLGMPQFLSGEAQS 296
Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAF 483
LL L +R+ RLG G +E+K PFF ++DW ++ ++ PP P G F
Sbjct: 297 LLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHF 356
Query: 484 D--IGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQ 519
D + D+ G+ + L+R F S Q+
Sbjct: 357 DPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQE 394
Score = 88.6 bits (218), Expect = 2e-17
Identities = 78/270 (28%), Positives = 125/270 (46%), Gaps = 31/270 (11%)
Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242
NIH T + + + IG G + C T YA+K +DK K E + +
Sbjct: 416 NIHFT-DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS--KRDPSEEIEI----- 467
Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302
L+ G P I+ + + + +++LM GG+L + + FSE + I
Sbjct: 468 --LLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTIT 525
Query: 303 LGLEHMHNRFVVYRDLKPANILL-DEHG---HVRISDLGLACDFSKKKPHASVG------ 352
++++H++ VV+RDLKP+NIL DE G +R+ D G A K+ A G
Sbjct: 526 KTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFA-----KQLRAGNGLLMTPC 580
Query: 353 -THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAV 411
T ++APEVL K YD++ D +SLG +L+ +L G +PF EI +
Sbjct: 581 YTANFVAPEVL-KRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKY 639
Query: 412 ELP----DSFSPELRSLLEGLLQRDVNRRL 437
L DS S + ++ +L D ++RL
Sbjct: 640 ALSGGNWDSISDAAKDVVSKMLHVDPHQRL 669
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 211 bits (536), Expect = 2e-54
Identities = 120/338 (35%), Positives = 193/338 (57%), Gaps = 15/338 (4%)
Query: 189 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245
+ F + +++G+G +G+V+ RK +D G++YAMK L K +K++ + ++ +
Sbjct: 57 SQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRD----RVRSKMERDI 112
Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305
++ + PFIV + YAF T KL ILD + GGDL LS+ +F+E D++FY AE+ L L
Sbjct: 113 LAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAL 172
Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQ 363
+H+H+ ++YRDLKP NILLDE GH++I+D GL+ + K+ ++ GT YMAPEV+
Sbjct: 173 DHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVN 232
Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423
+ + SADW+S G ++F++L G PF + KD+ E + L + +P S E +S
Sbjct: 233 RR-GHTQSADWWSFGVLMFEMLTGSLPF---QGKDRKETMALILKAKLGMPQFLSGEAQS 288
Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAF 483
LL L +R+ RLG G +E+K PFF ++DW ++ ++ PP P G F
Sbjct: 289 LLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHF 348
Query: 484 D--IGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQ 519
D + D+ G+ + L+R F S Q+
Sbjct: 349 DPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQE 386
Score = 88.6 bits (218), Expect = 2e-17
Identities = 78/270 (28%), Positives = 125/270 (46%), Gaps = 31/270 (11%)
Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242
NIH T + + + IG G + C T YA+K +DK K E + +
Sbjct: 408 NIHFT-DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS--KRDPSEEIEI----- 459
Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302
L+ G P I+ + + + +++LM GG+L + + FSE + I
Sbjct: 460 --LLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTIT 517
Query: 303 LGLEHMHNRFVVYRDLKPANILL-DEHG---HVRISDLGLACDFSKKKPHASVG------ 352
++++H++ VV+RDLKP+NIL DE G +R+ D G A K+ A G
Sbjct: 518 KTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFA-----KQLRAGNGLLMTPC 572
Query: 353 -THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAV 411
T ++APEVL K YD++ D +SLG +L+ +L G +PF EI +
Sbjct: 573 YTANFVAPEVL-KRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKY 631
Query: 412 ELP----DSFSPELRSLLEGLLQRDVNRRL 437
L DS S + ++ +L D ++RL
Sbjct: 632 ALSGGNWDSISDAAKDVVSKMLHVDPHQRL 661
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 209 bits (533), Expect = 5e-54
Identities = 119/326 (36%), Positives = 191/326 (58%), Gaps = 17/326 (5%)
Query: 191 FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247
F + +++G+G FG+V+ RK D G++YAMK L K +K++ + I++ +
Sbjct: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEV-- 130
Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307
+ PFIV + YAF T KL ILD + GGD+ LS+ +F+E D++FY AE+ L L+H
Sbjct: 131 --NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDH 188
Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQKG 365
+H +VYRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+ +
Sbjct: 189 LHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRR 248
Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425
+ SADW+S G ++F++L G PF + KD++E M L + +P S E +SLL
Sbjct: 249 -GHSQSADWWSYGVLMFEMLTGTLPF---QGKDRNETMNMILKAKLGMPQFLSAEAQSLL 304
Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFD- 484
L +R+ RLG G +E+K FF ++DW ++ ++ PP P G+ + FD
Sbjct: 305 RMLFKRNPANRLG--SEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDP 362
Query: 485 -IGSFDEEDTKGIKLLDSDQELYRNF 509
+ +D+ G+ + +L++ F
Sbjct: 363 EFTAKTPKDSPGLPASANAHQLFKGF 388
Score = 79.7 bits (195), Expect = 8e-15
Identities = 70/250 (28%), Positives = 114/250 (45%), Gaps = 20/250 (8%)
Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256
IG G + C A T +A+K +DK K E + + L+ G P I+
Sbjct: 432 IGVGSYSVCKRCIHATTNMEFAVKIIDKS--KRDPSEEIEI-------LMRYGQHPNIIT 482
Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316
+ F + + DLM GG+L + + FSE + I ++++H + VV+R
Sbjct: 483 LKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHR 542
Query: 317 DLKPANIL-LDEHG---HVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLQKGVAYDS 370
DLKP+NIL +DE +RI D G A + T ++APEVL + YD+
Sbjct: 543 DLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQ-QGYDA 601
Query: 371 SADWFSLGCMLFKLLRGHSPFRQHKTKDKHE----IDRMTLTMAVELPDSFSPELRSLLE 426
+ D +SLG + + +L G++PF E I +++ D+ S + LL
Sbjct: 602 ACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLS 661
Query: 427 GLLQRDVNRR 436
+L D ++R
Sbjct: 662 HMLHMDPHQR 671
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 208 bits (529), Expect = 2e-53
Identities = 121/316 (38%), Positives = 181/316 (57%), Gaps = 16/316 (5%)
Query: 188 MNDFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETL-ALNERIML 243
+ +F + +++G G +G+V+ RK DTGK+YAMK L K I K T ER +L
Sbjct: 46 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 105
Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303
+ PF+V + YAF T KL ILD +NGG+L HLSQ F+E +++ Y EI+L
Sbjct: 106 EHIRQS--PFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVL 163
Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF---SKKKPHASVGTHGYMAPE 360
LEH+H ++YRD+K NILLD +GHV ++D GL+ +F ++ ++ GT YMAP+
Sbjct: 164 ALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPD 223
Query: 361 VLQKG-VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDSFS 418
+++ G +D + DW+SLG ++++LL G SPF K+ EI R L P S
Sbjct: 224 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMS 283
Query: 419 PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVN 478
+ L++ LL +D +RLGC R A E+KE FF+ ++W + +K P P P
Sbjct: 284 ALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPV----- 338
Query: 479 AADAFDIGSFDEEDTK 494
D D+ +F EE T+
Sbjct: 339 IRDELDVSNFAEEFTE 354
Score = 55.8 bits (133), Expect = 1e-07
Identities = 35/124 (28%), Positives = 59/124 (47%), Gaps = 8/124 (6%)
Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256
+G G F C + + +A+K + K+ Q E AL + G P IV
Sbjct: 432 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALK-------LCEGH-PNIVK 483
Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316
+ FH +++L+NGG+L + + FSE + + +++ + HMH+ VV+R
Sbjct: 484 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543
Query: 317 DLKP 320
DLKP
Sbjct: 544 DLKP 547
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 208 bits (529), Expect = 2e-53
Identities = 121/316 (38%), Positives = 181/316 (57%), Gaps = 16/316 (5%)
Query: 188 MNDFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETL-ALNERIML 243
+ +F + +++G G +G+V+ RK DTGK+YAMK L K I K T ER +L
Sbjct: 46 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 105
Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303
+ PF+V + YAF T KL ILD +NGG+L HLSQ F+E +++ Y EI+L
Sbjct: 106 EHIRQS--PFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVL 163
Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF---SKKKPHASVGTHGYMAPE 360
LEH+H ++YRD+K NILLD +GHV ++D GL+ +F ++ ++ GT YMAP+
Sbjct: 164 ALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPD 223
Query: 361 VLQKG-VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDSFS 418
+++ G +D + DW+SLG ++++LL G SPF K+ EI R L P S
Sbjct: 224 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMS 283
Query: 419 PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVN 478
+ L++ LL +D +RLGC R A E+KE FF+ ++W + +K P P P
Sbjct: 284 ALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPV----- 338
Query: 479 AADAFDIGSFDEEDTK 494
D D+ +F EE T+
Sbjct: 339 IRDELDVSNFAEEFTE 354
Score = 99.0 bits (245), Expect = 1e-20
Identities = 78/269 (28%), Positives = 122/269 (45%), Gaps = 44/269 (16%)
Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256
+G G F C + + +A+K + K+ Q E AL + G P IV
Sbjct: 432 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALK-------LCEGH-PNIVK 483
Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316
+ FH +++L+NGG+L + + FSE + + +++ + HMH+ VV+R
Sbjct: 484 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543
Query: 317 DLKPANILLDEHG---HVRISDLGLACDFSKKKP------HASVGTHGYMAPEVLQKGVA 367
DLKP N+L + ++I D G F++ KP T Y APE+L +
Sbjct: 544 DLKPENLLFTDENDNLEIKIIDFG----FARLKPPDNQPLKTPCFTLHYAAPELLNQN-G 598
Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP------------- 414
YD S D +SLG +L+ +L G PF+ H +T T AVE+
Sbjct: 599 YDESCDLWSLGVILYTMLSGQVPFQSHDRS-------LTCTSAVEIMKKIKKGDFSFEGE 651
Query: 415 --DSFSPELRSLLEGLLQRDVNRRLGCLG 441
+ S E + L++GLL D N+RL G
Sbjct: 652 AWKNVSQEAKDLIQGLLTVDPNKRLKMSG 680
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 204 bits (520), Expect = 2e-52
Identities = 120/312 (38%), Positives = 177/312 (56%), Gaps = 18/312 (5%)
Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245
+TMNDF +++G+G FG+V R+ TG+ YAMK L K+ I K + E +L
Sbjct: 147 VTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQN 206
Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305
PF+ + YAF T D+L F+++ NGG+L +HLS+ VF+E RFY AEI+ L
Sbjct: 207 TRH---PFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSAL 263
Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA----CDFSKKKPHASVGTHGYMAPEV 361
E++H+R VVYRD+K N++LD+ GH++I+D GL D + K GT Y+APEV
Sbjct: 264 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFC--GTPEYLAPEV 321
Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 421
L+ Y + DW+ LG ++++++ G PF +D + + L + P + SPE
Sbjct: 322 LEDN-DYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHERLFELILMEEIRFPRTLSPEA 377
Query: 422 RSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAAD 481
+SLL GLL++D +RLG A+EV E FF S++WQ V +K PP P
Sbjct: 378 KSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKP-----QVTS 432
Query: 482 AFDIGSFDEEDT 493
D FD+E T
Sbjct: 433 EVDTRYFDDEFT 444
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 199 bits (505), Expect = 9e-51
Identities = 117/323 (36%), Positives = 181/323 (56%), Gaps = 16/323 (4%)
Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245
+TMN+F +++G+G FG+V ++ TG+ YAMK L K+ I K L E +L
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ- 203
Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305
PF+ + Y+F T D+L F+++ NGG+L +HLS+ VFSE RFY AEI+ L
Sbjct: 204 --NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
Query: 306 EHMHN-RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVL 362
+++H+ + VVYRDLK N++LD+ GH++I+D GL + K GT Y+APEVL
Sbjct: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321
Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422
+ Y + DW+ LG ++++++ G PF +D ++ + L + P + PE +
Sbjct: 322 EDN-DYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEEIRFPRTLGPEAK 377
Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADA 482
SLL GLL++D +RLG A+E+ + FF + WQ V+ +K PP P
Sbjct: 378 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP-----QVTSE 432
Query: 483 FDIGSFDEEDT-KGIKLLDSDQE 504
D FDEE T + I + DQ+
Sbjct: 433 TDTRYFDEEFTAQMITITPPDQD 455
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 199 bits (505), Expect = 9e-51
Identities = 117/323 (36%), Positives = 181/323 (56%), Gaps = 16/323 (4%)
Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245
+TMN+F +++G+G FG+V ++ TG+ YAMK L K+ I K L E +L
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ- 203
Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305
PF+ + Y+F T D+L F+++ NGG+L +HLS+ VFSE RFY AEI+ L
Sbjct: 204 --NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
Query: 306 EHMHN-RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVL 362
+++H+ + VVYRDLK N++LD+ GH++I+D GL + K GT Y+APEVL
Sbjct: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321
Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422
+ Y + DW+ LG ++++++ G PF +D ++ + L + P + PE +
Sbjct: 322 EDN-DYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEEIRFPRTLGPEAK 377
Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADA 482
SLL GLL++D +RLG A+E+ + FF + WQ V+ +K PP P
Sbjct: 378 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP-----QVTSE 432
Query: 483 FDIGSFDEEDT-KGIKLLDSDQE 504
D FDEE T + I + DQ+
Sbjct: 433 TDTRYFDEEFTAQMITITPPDQD 455
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 199 bits (505), Expect = 9e-51
Identities = 117/323 (36%), Positives = 181/323 (56%), Gaps = 16/323 (4%)
Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245
+TMN+F +++G+G FG+V ++ TG+ YAMK L K+ I K L E +L
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ- 203
Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305
PF+ + Y+F T D+L F+++ NGG+L +HLS+ VFSE RFY AEI+ L
Sbjct: 204 --NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
Query: 306 EHMHN-RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVL 362
+++H+ + VVYRDLK N++LD+ GH++I+D GL + K GT Y+APEVL
Sbjct: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321
Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422
+ Y + DW+ LG ++++++ G PF +D ++ + L + P + PE +
Sbjct: 322 EDN-DYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEEIRFPRTLGPEAK 377
Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADA 482
SLL GLL++D +RLG A+E+ + FF + WQ V+ +K PP P
Sbjct: 378 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP-----QVTSE 432
Query: 483 FDIGSFDEEDT-KGIKLLDSDQE 504
D FDEE T + I + DQ+
Sbjct: 433 TDTRYFDEEFTAQMITITPPDQD 455
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 198 bits (504), Expect = 1e-50
Identities = 116/311 (37%), Positives = 176/311 (56%), Gaps = 18/311 (5%)
Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246
TMNDF +++G+G FG+V R+ +GK YAMK L K+ I K L E +L
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT 203
Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306
PF+ + Y+F T D+L F+++ +NGG+L +HLS+ VFSE RFY AEI+ L+
Sbjct: 204 RH---PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALD 260
Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLA----CDFSKKKPHASVGTHGYMAPEVL 362
++H+ +VYRDLK N++LD+ GH++I+D GL D + K GT Y+APEVL
Sbjct: 261 YLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFC--GTPEYLAPEVL 318
Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422
+ Y + DW+ LG ++++++ G PF +D ++ + L ++ P + S + +
Sbjct: 319 EDN-DYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEDIKFPRTLSSDAK 374
Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADA 482
SLL GLL +D N+RLG A+E+ FF ++WQ V+ +K PP P
Sbjct: 375 SLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP-----QVTSE 429
Query: 483 FDIGSFDEEDT 493
D FDEE T
Sbjct: 430 TDTRYFDEEFT 440
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 198 bits (504), Expect = 1e-50
Identities = 116/311 (37%), Positives = 176/311 (56%), Gaps = 18/311 (5%)
Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246
TMNDF +++G+G FG+V R+ +GK YAMK L K+ I K L E +L
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT 203
Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306
PF+ + Y+F T D+L F+++ +NGG+L +HLS+ VFSE RFY AEI+ L+
Sbjct: 204 RH---PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALD 260
Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLA----CDFSKKKPHASVGTHGYMAPEVL 362
++H+ +VYRDLK N++LD+ GH++I+D GL D + K GT Y+APEVL
Sbjct: 261 YLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFC--GTPEYLAPEVL 318
Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422
+ Y + DW+ LG ++++++ G PF +D ++ + L ++ P + S + +
Sbjct: 319 EDN-DYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEDIKFPRTLSSDAK 374
Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADA 482
SLL GLL +D N+RLG A+E+ FF ++WQ V+ +K PP P
Sbjct: 375 SLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP-----QVTSE 429
Query: 483 FDIGSFDEEDT 493
D FDEE T
Sbjct: 430 TDTRYFDEEFT 440
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 196 bits (499), Expect = 5e-50
Identities = 120/314 (38%), Positives = 172/314 (54%), Gaps = 14/314 (4%)
Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242
N H +DF ++IG+G FG+V R YA+K L KK I K+ E ++ER +
Sbjct: 90 NPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNV 149
Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302
L + PF+V + ++F T DKL F+LD +NGG+L YHL + F E RFYAAEI
Sbjct: 150 L--LKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIA 207
Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPE 360
L ++H+ +VYRDLKP NILLD GH+ ++D GL + + S GT Y+APE
Sbjct: 208 SALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPE 267
Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420
VL K YD + DW+ LG +L+++L G PF T + ++ L ++L + +
Sbjct: 268 VLHK-QPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYD---NILNKPLQLKPNITNS 323
Query: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA 480
R LLEGLLQ+D +RLG E+K FF ++W + +K PP P N +
Sbjct: 324 ARHLLEGLLQKDRTKRLGAKD-DFMEIKSHVFFSLINWDDLINKKITPPFNP-----NVS 377
Query: 481 DAFDIGSFDEEDTK 494
D+ FD E T+
Sbjct: 378 GPNDLRHFDPEFTE 391
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 196 bits (499), Expect = 5e-50
Identities = 120/314 (38%), Positives = 172/314 (54%), Gaps = 14/314 (4%)
Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242
N H +DF ++IG+G FG+V R YA+K L KK I K+ E ++ER +
Sbjct: 104 NPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNV 163
Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302
L + PF+V + ++F T DKL F+LD +NGG+L YHL + F E RFYAAEI
Sbjct: 164 L--LKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIA 221
Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPE 360
L ++H+ +VYRDLKP NILLD GH+ ++D GL + + S GT Y+APE
Sbjct: 222 SALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPE 281
Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420
VL K YD + DW+ LG +L+++L G PF T + ++ L ++L + +
Sbjct: 282 VLHK-QPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYD---NILNKPLQLKPNITNS 337
Query: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA 480
R LLEGLLQ+D +RLG E+K FF ++W + +K PP P N +
Sbjct: 338 ARHLLEGLLQKDRTKRLGAKD-DFMEIKSHVFFSLINWDDLINKKITPPFNP-----NVS 391
Query: 481 DAFDIGSFDEEDTK 494
D+ FD E T+
Sbjct: 392 GPNDLRHFDPEFTE 405
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 196 bits (499), Expect = 5e-50
Identities = 120/314 (38%), Positives = 172/314 (54%), Gaps = 14/314 (4%)
Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242
N H +DF ++IG+G FG+V R YA+K L KK I K+ E ++ER +
Sbjct: 118 NPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNV 177
Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302
L + PF+V + ++F T DKL F+LD +NGG+L YHL + F E RFYAAEI
Sbjct: 178 L--LKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIA 235
Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPE 360
L ++H+ +VYRDLKP NILLD GH+ ++D GL + + S GT Y+APE
Sbjct: 236 SALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPE 295
Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420
VL K YD + DW+ LG +L+++L G PF T + ++ L ++L + +
Sbjct: 296 VLHK-QPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYD---NILNKPLQLKPNITNS 351
Query: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA 480
R LLEGLLQ+D +RLG E+K FF ++W + +K PP P N +
Sbjct: 352 ARHLLEGLLQKDRTKRLGAKD-DFMEIKSHVFFSLINWDDLINKKITPPFNP-----NVS 405
Query: 481 DAFDIGSFDEEDTK 494
D+ FD E T+
Sbjct: 406 GPNDLRHFDPEFTE 419
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,635,517
Number of Sequences: 37866
Number of extensions: 1204725
Number of successful extensions: 5506
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 672
Number of HSP's successfully gapped in prelim test: 155
Number of HSP's that attempted gapping in prelim test: 3396
Number of HSP's gapped (non-prelim): 1034
length of query: 689
length of database: 18,247,518
effective HSP length: 109
effective length of query: 580
effective length of database: 14,120,124
effective search space: 8189671920
effective search space used: 8189671920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.